高齢者ブレインバンク http://www2.tmig.or.jp/brainbk/
リソース研究_研究成果_2015 年
1.

Kuninaka, N., M. Kawaguchi, M. Ogawa, A. Sato, K. Arima, S. Murayama and Y.
Saito. Simplification of the modified Gallyas method. Neuropathology 2015, 35:10-15.

2. Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C,Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H: Comprehensive phosphoproteome
analysis unravels the core signaling network that initiates the earliest synapse pathology inpreclinical Alzheimer's disease brain. Hum Mol Genet 2015, 24(2): 540- 558.
3. Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y,Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N: Anaberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease.
EMBO Molecular Medicine 2015, 7(2): 175- 189
4. Kuninaka N, Kawaguchi M, Ogawa M, Sato A, Arima K, Murayama S, Saito Y: Simplification ofthe modified Gallyas method. Neuropathology 2015, 35(1): 10-15
5. Oikawa N, Matsubara T, Fukuda R, Yasumori H, Hatsuta H, Murayama S, Sato T, Suzuki A,Yanagisawa K: Imbalance in Fatty-Acid-chain length of gangliosides triggers Alzheimer amyloid
deposition in the precuneus. PLoS One 2015: 10(3) e0121356. doi:10.1371/journal.pone.0121356
6. Sabri O, Sabbagh MN, Seibyl J, Barthel H, Akatsu H, Ouchi Y, Kohei Senda K, Murayama S,Ishii K, Takao M, Beach T.G, Rowe C.C,Leverenz NB, Ghetti B, Ironside JW, Catafau AM,Stephens AW, Mueller A, Koglin N, Hoffmann A, Katrin Roth K, Cornelia Reininger C,
Schulz-Schaeffer WJ, for the Florbetaben Phase 3 Study Group: 18F-florbetaben PET imaging ofamyloid plaques to detect Alzheimer disease: results from a multicenter histopathological Study.
Alzheimers Dement 2015, 11(8): 964-974
7. Hatsuta H, Takao M, Ishii K, Ishiwata K, Saito Y, Kanemaru K, Arai t, Suhara T, Shimada H,Shinotoh H, Tamaoka A, Murayama S: Amyloid beta Accumulation Assessed with
11C-Pittsburgh Compound B PET and Postmortem Neuropathology. Curr Alzheimer Res 2015,12(3): 278-286
8. Miyamoto R, Sumikura H, Takeuchi T, Sanada M, Fujita K, Kawarai T, Mure H, Morigaki R,Goto S, Murayama S, Izumi Y, Kaji R: Autopsy case of severe generalized dystonia and staticataxia with marked cerebellar atrophy. Neurology 2015, 85:1522-1524
9. Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Durr A, Brice A, Takashima H,Kikuchi A, Aoki M, Ishiura H, Yasuda T, Date H, Ahsan B, Iwata A, Goto J, Ichikawa Y,Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O,Nishizawa M, Watanabe H, Ito M, Sobue G, Ishikawa K, Mizusawa H, Kanai K, Hattori T,Kuwabara S, Arai K, Koyano S, Kuroiwa Y, Hasegawa K, Yuasa T, Yasui K, Nakashima K, Ito H,Izumi Y, Kaji R, Kato T, Kusunoki S, Osaki Y, Horiuchi M, Kondo T, Murayama S, Hattori N,Yamamoto M, Murata M, Satake W, Toda T, Filla A, Klockgether T, Wullner U, Nicholson G,Gilman S, Tanner CM, Kukull WA, Stern M B, Lee VM, Trojanowski JQ, Masliah E, Low PA,Sandroni P, Ozelius LJ, Foroud T, Tsuji S: Variants associated with Gaucher disease in multiple
system atrophy. Ann Clin. Transl Neurol 2015, 2(4) 417- 4261

10. Nishimura K, Murayama S, Takahashi J: Identification of neurexophilin 3 as a novel supportive
factor for survival of induced pluripotent stem cell-derived dopaminergic progenitors stem Cells.
Transl Med. 2015, 4(8): 932-944
11. Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H,Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y,Mochizuki H, Obata F, Okano H: I2020T mutant LRRK2 iPSC-derived neurons in the
Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling
pathway. Human Mol Genet 2015, 24(17): 4879-4900
12. Shioya A, Saito Y, Arima K, Kakuta Y, Yuzuriha T, Tanaka N, Murayama S, Tamaoka A:
Neurodegenerative changes in patients with clinical history of bipolar disorders. Neuropathology
2015, 35 (3) 245-253
13. Uchino A, Takao M, Hatsuta H, Sumikura H, Nakano Y, Nogami A, Saito Y, Arai T, Nishiyama K,Murayama S: Incidence and extent of TDP-43 accumulation in aging human brain. Acta
Neuropathol Commun 2015, 3: 35. doi:10.1186/s40478-015-0215-1
14. Sakurai K, Imabayashi E, Tokumaru A. M, Hasebe S, Murayama S, Morimoto S, Kanemaru K,Takao M, Shibamoto Y, Matsukawa N: The feasibility of white matter volume reduction analysis
using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal
syndrome and Richardson's syndrome, Neuroimage Clin 2015, 7: 605-610
15. Ishigami A, Masutomi H, Handa S, Nakamura M, Nakaya S, Uchida Y, Murayama S, Jang B,Jeon Y-C, Choi E-K, Kim Y-S, Kasahara Y, Maruyama N, Toda T: Mass spectrometricidentification of citrullination sites and immunohistochemical detection of citrullinated glial
fibrillary acidic protein in Alzheimer’s disease brains. J Neurosci Res 2015, 93 (11): 1664-1674
16. Sumikura H, Takao M, Hatsuta H, Ito S, Nakano Y, Uchino A, Nogami A, Saito Y, Mochizuki H,Murayama S: Distribution of phosphorylated α-synuclein in the spinal cord and dorsal root
ganglia in an autopsy cohort of elderly persons. Acta Neuropathol Commun2015, 3:57.
doi:10.1186/s40478-015-0236-9
17. Yoshimi T, Kawabata S, Taira S, Okuno A, Mikawa R, Murayama S, Tanaka K, Takikawa O:
Affinity imaging mass spectrometry (AIMS): high-throughput screening for specific small
molecule interactions with frozen tissue sections. Analyst 2015, 140(21):7202-7208
DOI: 10.1039/c5an01381j
18. Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T,Fox N. C, Murayama S, Gijsen H, De Strooper B, Chavez-Gutierrez L: Qualitative changes in brain
Aβ profiles form the basis of γ-secretase mediated neurodegeneration in familial Alzheimer disease.
J Exp Med 2015, 212 (12): 2003-13
19. Yoshimoto T, Takahashi-Fujigasaki J, Inoshita N, Fukuhara N, Nishioka H, Yamada S :TTF-1-positive oncocytic sellar tumor with follicle formation/ependymal differentiation:
non-adenomatous tumor capable of two different interpretations as a pituicytoma or a spindle celloncocytoma. Brain Tumor Pathol 2015, 32(3): 221-227.

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20. Fuga M, Tanaka T, Yamamoto Y, Hasegawa Y, Murayama Y, Takahashi-Fujigasaki J : Lipoma inthe Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal
Edema: A Case Report and Literature Review. Case Rep Neurol Med. 2015,
doi.10.1155/2015/520208.
21. Nogami A, Yamazaki M, Saito Y, Hatsuta H, Sakiyama Y, Takao M, Kimura K, Murayama S.
Early Stage of Progressive Supranuclear Palsy: A Neuropathological Study of 324 ConsecutiveAutopsy Cases. J Nippon Med Sch 2015, 82(6):266-273.
22. Tagawa, K., H. Homma, A. Saito, K. Fujita, X. Chen, S. Imoto, T. Oka, H. Ito, K.
Motoki, C. Yoshida, H. Hatsuta, S. Murayama, T. Iwatsubo, S. Miyano and H.
Okazawa. Comprehensive phosphoproteome analysis unravels the core signaling
network that initiates the earliest synapse pathology in preclinical Alzheimer's
disease brain. Hum Mol Genet. 2015, 24(2):540-558
23. Tokushige S, Sasaki T, Hatsuta H, Uchino A, Kakuta Y, Shimizu J, Tsuji S, Nakayama T, ImafukuI, Murayama S. Accumulation of transportin 1 in the fused in sarcoma-positive neuronal
inclusions in sporadic amyotrophic lateral sclerosis without FUS mutation. Neurol Clin
Neurosci. 2015, 3: 194-196

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