ᐔᚑ 㪉㪉 ᐕᐲෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄䋨ᚑ⢒∔ᖚస᦯╬ᰴ਎ઍ⢒ᚑၮ⋚⎇ⓥ੐ᬺ䋩㩷ಽᜂ⎇ⓥႎ๔ᦠ㩷㩷ಽᜂ⺖㗴䋺ᆌᆂᨴ⦡૕ߩ⇣ᢙᕈߦ㑐ߔࠆ⎇ⓥ㩷
㩷⎇ⓥಽᜂ⠪㩷 㩷 ᩉේ㩷 ᩰ㩷 ᄢ㒋ᐭ┙Უሶ଻ஜ✚วක≮䉶䊮䉺䊷⎇ⓥᚲ㩷⎇ⓥදജ⠪㩷 㩷 ๧᧛๺຦㩷 ᄢ㒋ᐭ┙Უሶ଻ஜ✚วක≮䉶䊮䉺䊷⎇ⓥᚲ㪆ᄢ㒋ᄢቇ㩷⎇ⓥදജ⠪㩷 㩷 శ↰ା᣿㩷 ᄢ㒋ᐭ┙Უሶ଻ஜ✚วක≮䉶䊮䉺䊷↥⑼㩷
㩷⎇ⓥⷐᣦ㩷ᆌᆂᨴ⦡૕⇣ᢙᕈ䉕⿠䈜䊝䊂䊦䊜䉻䉦䈱૞ᚑ䈮ᚑഞ䈚䈢䇯ᧄᐕᐲ䈲㐳䉌䈒ቇળ╬䈪䉅⼏⺰䈘䉏䈩䈐䈢ᵹᣧ↥⿠࿃⚦⩶䉡䊧䉝䊒䊤䉵䊙䈮䈧䈇䈩Ἳ∝෻ᔕᗖ⿠䊜䉦䊆䉵䊛䈱⸃ᨆ䉕ⴕ䈦䈢䇯䉡䊧䉝䊒䊤䉵䊙䈱๟↥ᦼ㗔ၞ䈮䈍䈔䉎∛ේ࿃ሶ䈫䈚䈩⥃ᐥಽ㔌ᩣ↱᧪♖⵾䊥䊘Ⱞ⊕⾰෸䈶䇮วᚑ䊥䊘䊕䊒䉼䊄䉕หቯ䈚䇮㫀㫅㩷㫍㫀㫋㫉㫆㪆㫀㫅㩷㫍㫀㫍㫆 䈮䈍䈇䈩䈠䈱∛ේᕈ䊶∛ᘒ䊜䉦䊆䉵䊛䉕⸽᣿䈚䈢䇯䈘䉌䈮䇮ᣂ䈢䈭ಾ䉍ญ䈫䈚䈩∛ේᓸ↢‛䈱☸ሶᓘ䈏∛ේ⊒ើᯏ᭴䈮ነਈ䈜䉎น⢻ᕈ䉕␜䈚䈢䇯䉁䈢䇮ᣣᧄੱ⠌ᘠᕈᵹ↥ᖚ⠪䈮ᄙ䈒⹺䉄䉌䉏䉎 㪪㪥㪧 䉕หቯ䈚䇮䈅䉌䈢䈭ᴦ≮ᚢ⇛䈱น⢻ᕈ䈏␜ໂ䈘䉏䈢䈱䈪䈅䉒䈞䈩ႎ๔䈜䉎䇯㩷㩷䌁䋮⎇ⓥ⋡⊛㩷㪈㪐㪌㪋㩷 ᐕ㪪㪿㪼㫇㪸㫉㪻䈮䉋䈦䈩䊍䊃䉡䊧䉝䊒䊤䉵䊙䈏ಽ㔌䈘䉏䈩એ᧪䋬䈠䈱∛ේᕈ䈮䈧䈇䈩䈲⼏⺰䈏⛯䈇䈩䈐䈢䇯䈠䈱ℂ↱䈫䈚䈩䇮ᧄ⩶䈏ஜᐽᚑੱ↢ᱺེౝ䉋䉍㜞₸䈮䋨㪋㪇㪄㪏㪇䋦䋩ಽ㔌䈘䉏䈩䈍䉍䇮䉅䈲䉇ᱜᏱ⚦⩶ฌ䉕ᒻᚑ䈜䉎⚦⩶䈱৻⒳䈫䈚䈩⹺⼂䈘䉏䈩䈇䉎䈖䈫䇮䉁䈢⩶䈱ಽ㔌ၭ㙃䉇ⴊᷡቇ⊛⸻ᢿ䈏৻⥸䈮㔍䈚䈇䈖䈫䈭䈬䈏䈅䈕䉌䉏䉎䇯䈠䈖䈪䇮ᚒ䇱䈲䇮ᡷ⦟ဳ䉡䊧䉝䊒䊤䉵䊙ၭ࿾䉕૞⵾䈚䇮㪬㫉㪼㪸㫇㫃㪸㫊㫄㪸㩷㫊㫇㫇㪅㩷 䉇㪤㫐㪺㫆㫇㫃㪸㫊㫄㪸㩷㪿㫆㫄㫀㫅㫀㫊䈱ಽ㔌䉕ⴕ䈦䈩䈐䈢䇯೨ᣇⷞ⊛䈮ⴕ䈦䈢ᵹᣧ↥⢝⋚㩿㪈㪌㪈଀㪀䈱㪬㫉㪼㪸㫇㫃㪸㫊㫄㪸㩷㫊㫇㫇㪅䈱ၭ㙃䈪䈲㪋㪉㩼䈏ၭ㙃㓁ᕈ䈪䈅䈦䈢䇯∉ቇ⊛䈮㪚㪘㪤䈫㪬㫉㪼㪸㫇㫃㪸㫊㫄㪸㩷㫊㫇㫇㪅ၭ㙃㓁ᕈ䈱㑐ㅪᕈ䉕ႎ๔䈚䈢㩿㪥㪸㫄㪹㪸㩷㩽㩷㪟㪸㫊㪼㪾㪸㫎㪸㪃㩷㪧㪼㪻㪅㩷㪩㪼㫊㪅㩷㪉㪇㪈㪇㪀䇯㩷䋱䋮ᧄ⎇ⓥ䈪䈲ૐ∛ේᕈ⚦⩶䈱∛ේᕈ䉕⸽᣿䈜䉎⋡⊛䈮䈩䉡䊧䉝䊒䊤䉵䊙䈱∛ේ࿃ሶ䉕หቯ䈚䈢䇯㩷䋲䋮䉡䊧䉝䊒䊤䉵䊙䈲ᦨዊ䈱⚦⩶䈪䈠䈱䉰䉟䉵䈲㪈㪇㪇㪄㪊㪇㪇㫅㫄䈪䈅䉎䇯䊅䊉䉲䊥䉦䉕↪䈇䈢☸ሶ䈱ᅧᆼ䊙䉡䉴ᛩਈ䉕ⴕ䈇䇮☸ሶ䉰䉟䉵䈫⢝⋚ᯏ⢻㓚ኂ䈮䈧䈇䈩⸃ᨆ䉕ⴕ䈦䈢䇯㩷䋳䋮ᄢⷙᮨ䈭ᶏᄖ䈱⺞ᩏ䈪䇮䊓䊌䊥䊮≮ᴺ䈲ේ࿃ਇ᣿䈱⠌ᘠᕈᵹ↥䈮䈲ലᨐ䈏⹺䉄䉌䉏䈭䈇䈫䈘䉏䉎䇯䈠䈖䈪ᣣᧄੱ⠌ᘠᕈᵹ↥ᖚ⠪䈱ㆮવ⊛ⷐ࿃䈮䈧䈇䈩㪪㪥㪧⸃ᨆ䈚䇮䈖䉏䉁䈪ේ࿃ਇ᣿䈫䈘䉏䈩䈐䈢⠌ᘠᕈᵹ↥ᖚ⠪䈮䈍䈇䈩䉅᛫ಝ࿕≮ᴺ䈭䈬䈱ㆡᔕ䈫䈭䉎น⢻ᕈ䈱䈅䉎ᖚ⠪䉕ಽ㘃䈚䇮ᴦ≮ኻ⽎䈫䈭䉎䈱䈎ุ䈎䉕ᬌ⸛䈜䉎䈢䉄䈱⸃ᨆ䉕ⴕ䈦䈢䋨ฦ␠ႎ㆏䋩䇯㩷㩷䌂䋮⎇ⓥᣇᴺ㩷䋱䋮㩷 䉡䊧䉝䊒䊤䉵䊙䈱∛ේ࿃ሶត⚝㩷䈖䉏䉁䈪䈮䊙䉟䉮䊒䊤䉵䊙䈱䊥䊘Ⱞ⊕⾰䈲㪫㪣㪩㪉㪃㩷 㪫㪣㪩㪍 䈮⚿ว䈚䇮䉲䉫䊅䊦䉕⚦⢩ౝ䈮વ䈋䈩䈇䉎䈖䈫䈏⍮䉌䉏䈩䈇䉎䇯䉡䊧䉝䊒䊤䉵䊙䈮䉅䈠䈱䉋䈉䈭఺∉෻ᔕ䉕ᗖ⿠䈜䉎䊥䊘Ⱞ⊕⾰䈱ሽ࿷䈲⍮䉌䉏䈩䈇䈢䇯䈠䈖䈪䇮䉡䊧䉝䊒䊤䉵䊙ၭ㙃ᶧ䉋䉍䇮㪫㫉㫀㫋㫆㫅㪯㪄㪈㪈㪋㩷 ੑጀಽ㔌ᴺ䈮䉋䉍䊥䊘Ⱞ⊕⾰䉕♖⵾䈚䇮䉁䈢䇮䉳䉝䉲䊦ൻ䈚䈢䊕䊒䉼䊄䉕วᚑ䈚䈢䇯㪫㪣㪩㪉 䉕ዉ౉䈚䈢 㪟㪼㪣㪸 ⚦⢩䉕♖⵾䈚䈢䊥䊘Ⱞ⊕⾰෸䈶䇮วᚑ䊥䊘䊕䊒䉼䊄䈪ೝỗ䈚䇮㪥㪝㪄㱖㪙 ᵴᕈ䉕䊦䉲䊐䉢䊤䊷䉷䉝䉾䉶䉟䈮䈩᷹ቯ䈚䈢䇯ᰴ䈮♖⵾䊥䊘Ⱞ⊕⾰෸䈶䇮วᚑ䊥䊘䊕䊒䉼䊄䉕ᅧᆼ 㪈㪌 ᣣ⋡䈱䊙䉡䉴䈱ሶችౝ䈮ᛩਈ䈚䇮ᅧᆼ 㪈㪏 ᣣ⋡䈮䈍䈔䉎⢝੿䊶⢝⋚䈻䈱ᓇ㗀䉕⺞䈼䈢䇯㩷䋲䋮㩷 ☸ሶ䉰䉟䉵䈫䊙䉡䉴⢝⋚ᯏ⢻㓚ኂ䈱⸃ᨆ㩷ᅧᆼ 㪈㪍 ᣣ䊙䉡䉴䈮ᐔဋ☸ሶᓘ 㪎㪇㫅㫄㪃㩷 㪊㪇㪇㫅㫄㪃㩷㪈㪇㪇㪇㫅㫄 䈱䉲䊥䉦☸ሶ䉕䈠䉏䈡䉏የ㕒⣂䉋䉍㕒⣂ౝᛩਈ䈚䇮㪈㪏 ᣣ⋡䈮⸃ᨆ䉕ⴕ䈦䈢䇯㩷䋳䋮㩷 ⠌ᘠᕈᵹ↥ 㪪㪥㪧 ⸃ᨆ㩷䉝䊈䉨䉲䊮 㪘㪌 ㆮવሶ䈱䊒䊨䊝䊷䉺䊷㗔ၞ䈱179㪪㪥㪧 ⸃ᨆ䉕䈍䈖䈭䈦䈢䇯㩷㩷㩷 㩷 㩷 㩿୶ℂ㕙䈻䈱㈩ᘦ㪀㩷ᣉ⸳ౝ୶ℂᆔຬળ䇮േ‛ᆔຬળ䈪ᛚ⹺䉕ฃ䈔䇮ⷙቯ䉕ㆩ቞䈚⎇ⓥ䉕ⴕ䈦䈢䇯㩷㩷㩷㩷㩷䌃䋮⎇ⓥ⚿ᨐ㩷䋱䋮䊦䉲䊐䉢䊤䊷䉷䉝䉾䉶䉟䈪䈲䇮♖⵾䊥䊘Ⱞ⊕⾰䈲 㪥㪝㪄㱖㪙 䉕ᵴᕈൻ䈚䇮㪚㫆㫅㫋㫉㫆㫃 䈮Ყ䈼䇮㪏㪅㪋 ୚䈱਄᣹䈏䉂䉌䉏䈢㩷 㩿㪧㪓㪇㪅㪇㪇㪇㪈㪀㩷 䇯วᚑ䊥䊘䊕䊒䉼䊄䈮䈍䈇䈩䉅䇮㩷 㪥㪝㪄㱖㪙 䉕ᵴᕈൻ䈚䇮㪚㫆㫅㫋㫉㫆㫃 䈮Ყ䈼䇮㪉㪋㪅㪐 ୚䈱਄᣹䈏䉂䉌䉏䈢㩷 㩿㪧㪔㪇㪅㪇㪈㪉㪉㪀㩷 䇯㩷 㩷ᅧᆼ䊙䉡䉴䈻䈱♖⵾䊥䊘Ⱞ⊕⾰䈱ሶችౝᛩਈ䈪䈲 䇮 㪊㪏㪅㪌㩼㩷 㩿㪉㪇㪆㪌㪉㪀㩷 䈱 ⢝ ੿ ᱫ ੢ 䈏 ⏕ ⹺ 䈘 䉏 䇮㪚㫆㫅㫋㫉㫆㫃 ⟲ 䈱 㪈㪋㪅㪇㩼㩷 㩿㪎㪆㪌㪇㪀㩷 䉕 ᦭ ᗧ 䈮 ਄ ࿁ 䈦 䈢㩷㩿㪧㪔㪇㪅㪇㪇㪌㪀 䇯ว ᚑ 䊥 䊘 䊕䊒䉼 䊄 䈮 䈍 䈇 䈩 䉅 䇮 㪌㪎㪅㪐㩼㩷㩿㪈㪈㪆㪈㪐㪀㩷 䈱⢝੿ᱫ੢䈏⏕⹺䈘䉏䇮㪚㫆㫅㫋㫉㫆㫃 ⟲䈱㪈㪏㪅㪈㩼㩷 㩿㪋㪆㪉㪉㪀㩷 䉕᦭ᗧ䈮਄࿁䈦䈢㩷 㩿㪧㪔㪇㪅㪇㪇㪐㪀䇯⢝⋚䈪䈲 㫃㪸㪹㫐㫉㫀㫅㫋㪿 㗔ၞ䈮䈍䈔䉎⛐Ძ᭴ㅧ䈱⪜❗䊶Უ੿㑆Ⴚ⇇㕙䈱ᷫዋ䈫䈇䈦䈢ᚲ⷗䈏ᓧ䉌䉏䈢䇯㩷㩷䋲䋮ᐔဋ☸ሶᓘ 㪎㪇㫅㫄 䈱䉂⢝⋚䈮☸ሶ䈏㓸Ⓧ䈚䈢 䇯 䈘 䉌 䈮 㪎㪇㫅㫄 ☸ ሶ 䈲 䊙 䉡 䉴 ⢝ ⋚ 䈱㪪㫇㫆㫅㪾㫀㫆㫋㫉㫆㫇㪿㫆㪹㫃㪸㫊㫋 ጀ䉕․⇣⊛䈮㓚ኂ䈚䇮䉝䊘䊃䊷䉲䉴䉕⺃ዉ䈚䈢䇯䈖䉏䉌䈱ᚲ⷗䈲 㪊㪇㪇㫅㫄 䈅䉎䈇䈲 㪈㪇㪇㪇㫅㫄 䈱☸ሶ䈪䈲⹺䉄䉌䉏䈭䈎䈦䈢䇯㩷㩷䋳䋮䉝䊈䉨䉲䊮 㪘㪌 䈫䈇䈉ㆮવሶ䈱ㆮવᥧภ䈱㈩೉䈱୘ੱᏅ䈪䇮⠌ᘠᕈᵹ↥䈱ᅚᕈᖚ⠪䈱 㪈㪇㪄㪉㪇䋦䈏㜞䊥䉴䉪ဳ䉕ᜬ䈦䈩䈍䉍䇮㜞䊥䉴䉪ဳ䉕ᜬ䈧䈫⠌ᘠᕈᵹ↥䈱䊥䉴䉪䈏⚂䋲୚Ⴧട䈜䉎䈫⠨䈋䉌䉏䈢䇯⢝⋚䈲䇮⢝ఽ䈏Უ૕ⴊᶧ䈎䉌㉄⚛䉇ᩕ㙃ಽ䉕ฃ䈔ข䉎⤳ེ䈣䈏䇮䉝䊈䉨䉲䊮 㪘㪌 䈲⢝⋚䈱ਛ䈱⢝ఽ஥⴫㕙䉕䈍䈍䈦䈩䇮䉉䈦䈒䉍䈫ᵹ䉏䈩䈇䉎Უ૕ⴊ䈏⢝⋚䈱⴫㕙䈪ಝ࿕䈜䉎䈖䈫䈎䉌଻⼔䈜䉎૞↪䉕ᜬ䈧䇯䉝䊈䉨䉲䊮 㪘㪌 ㆮવሶ䈱㈩೉䈏㜞䊥䉴䉪ဳ䈱ᅚᕈ䈱႐ว䈲䇮ㅢᏱဳ䈱ᅚᕈ䉋䉍䉅䉝䊈䉨䉲䊮 㪘㪌 䈱↥↢㊂䈏ૐ䈒䇮䈠䈱䈢䉄⢝⋚ౝ䈪ⴊᶧ䈏ಝ࿕䈚䉇䈜䈒䈭䉍䇮⢝ఽ䈱⊒⢒䈏㒖ኂ䈘䉏䇮ᵹ↥䈱࿁ᢙ䈏Ⴧ䈋䉎䈫ផቯ䈘䉏䈢䇯㩷㩷䌄䋮⠨ኤ㩷䋱䋮㪢㪦㪚㪟 䈱ේೣ䈮୮䈇䇮䉡䊧䉝䊒䊤䉵䊙䈮䉋䉎఺∉෻ᔕᗖ⿠ᯏ᭴䈱⸃ᨆ䋨∛ේ࿃ሶត⚝䋩䉕ⴕ䈦䈢䇯♖⵾䈚䈢䊥䊘Ⱞ⊕⾰෸䈶䇮วᚑ䊥䊘䊕䊒䉼䊄180䈲౒䈮 㪫㪣㪩㪉 䉕੺䈚䈩⚦⢩ౝ䈮䉲䉫䊅䊦䉕વ㆐䈜䉎䈖䈫䉕␜䈚䈢䇯ᰴ䈮♖⵾䊥䊘Ⱞ⊕⾰෸䈶䇮วᚑ䊥䊘䊕䊒䉼䊄䉕ᅧᆼ䊙䉡䉴䈱ሶችౝ䈮ᛩਈ䈚䈢⚿ᨐ䇮੹࿁↪䈇䈢ᛩਈ㊂䈮䈍䈇䈩䈲䇮䊙䉡䉴䈮⢝ౝᱫ੢䉕⿠䈖䈜䈖䈫䈏䉒䈎䈦䈢䇯੹ᓟ䈘䉌䈮⸃ᨆ䉕ㅴ䉄䉎䇯㩷䋲䋮☸ሶᓘ䈮䉋䈦䈩⢝⋚ᯏ⢻㓚ኂ䈏ᗖ⿠䈘䉏䉎䈖䈫䈏䉒䈎䈦䈢䇯੹ᓟ䈲䈠䈱䊜䉦䊆䉵䊛䈮䈧䈇䈩⸃ᨆ䉕ㅴ䉄䉎䇯㩷㧟㧚੹࿁ߩᣣᧄੱ SNP ⎇ⓥ߆ࠄ‫ޔ‬⠌ᘠᕈᵹ↥ߩᖚ⠪ߢߪࠕࡀࠠࠪࡦ A5 ߩㆮવሶᄙဳࠍ⺞ߴߡ‫ޔ‬㜞࡝ࠬࠢဳࠍᜬߟᖚ⠪ߦኻߒߡߪ᛫ಝ࿕≮ᴺࠍ߅ߎߥ߁‫߁޿ߣޔ‬ᣂߒ޿ᴦ≮ᚢ⇛ߩน⢻ᕈ߇␜ߐࠇߚ‫ޕ‬㩷㩷䌅䋮⚿⺰㩷䉡䊧䉝䊒䊤䉵䊙䈱∛ේ࿃ሶ䉕หቯ䈚䇮㐳䉌䈒⼏⺰䈘䉏䈩䈐䈢∛ේᕈ䉕⸽᣿䈚䈢䇯䉁䈢䇮ᓥ᧪⠨䈋䉌䉏䈭䈎䈦䈢☸ሶᓘ䈏∛ේ⊒ើ䈮ነਈ䈜䉎น⢻ᕈ䉕␜䈚䈢䇯㩷୘‫ߩޘ‬⠌ᘠᕈᵹ↥ߩᅚᕈߦኻߒߡ‫ࡓࡁࠥޔ‬ᖱႎࠍ೑↪ߒߡᖚ⠪ࠍ඙೎ߒ‫ߩࠇߙࠇߘޔ‬ᖚ⠪ߦኻߒߡᦨ߽ലᨐߩ޽ࠆᴦ≮ᴺࠍㆬᛯߔࠆߣ޿߁‫ޔ‬޿ࠊࠁࠆ‫ޟ‬⠌ᘠᕈᵹ↥ߩࡄ࡯࠰࠽࡜ࠗ࠭࠼ක≮‫৻╙ߩ߳ޠ‬ᱠߣߒߡᦼᓙߐࠇࠆ⚿ᨐߣߥߞߚ‫ޕ‬㩷㩷䌆䋮ஜᐽෂ㒾ᖱႎ㩷㩷 㩷 ․䈮䈭䈚㩷㩷䌇䋮⎇ⓥ⊒⴫㩷㪈㪅 ⺰ᢥ⊒⴫㩷㪈㪀 Miyamura H, Nishizawa H, Ota S, Suzuki M,Inagaki A, Egusa H, Nishiyama S, Kato T,
Pryor-Loishi K, Nakanishi I, Fujita T, Ymayoshi
Y, Markoff A, Yanagihara I, Udagawa Y,
Kurahashi H. Polymorphism in annexin A5 genepromoter in Japanese women with recurrent
pregnancy loss. Molecular Human Reproduction.
in press.
㪉㪀 Nozaki M, Wakae K, Tamaki N, Sakamoto S,
Ohnishi K, Uejima T, Minato N, Yanagihara I*,
Agata Y. Regulation of T cell receptor VJ2 generearrangement by the Helix-Loop-Helix protein,E2A. International Immunology, in press
㪊㪀 Ohnishi K, Nakahira K, Unzai S, Mayanagi K,㪋㪀㪌㪀㪍㪀㪎㪀㪏㪀㪐㪀Hashimoto H, Honda T, Yanagihara I*
Relationship between heat-induced
fibrillogenicity and hemolytic activity ofthermostable direct hemolysin and a related
hemolysin of Vibrio parahaemolyticus. FEMS
Microbiology letters, in press
Yanagihara I*, Nakahira K, Yamane T, Kaieda
S, Mayanagi K, Hamada D, Fukui T, Ohnishi K,Kajiyama S, Shimizu T, Sato M, Ikegami T,Ikeguchi M, Honda T, Hashimoto H. Structureand functional characterization of Vibrio
parahaemolyticus thermostable direct
hemolysin. The Journal of Biological Chemistry,
285(21), pp16267-74, 2010
Nishihara M, Sonoda M, Matsunami K,Yanagihara K, Yonemoto N, Ida S, Namba F,
Shimomura I, Yanagihara I*, Waguri M. Birthlength is a predictor of adiponectin levels inJapanese young children. Journal of PediatricEndocrinology & Metabolism, 23, pp913-920,
2010
Nishihara M, Yamada M, Nozaki M, NakahiraK, Yanagihara I*. Transcriptional regulation of
the human establishment of cohesion 1 homolog
2 gene. Biochemical and Biophysical ResearchCommunications, 393(1), pp111-7, 2010
Namba F, Hasegawa T, Nakayama M,
Hamanaka T, Yamashita T, Nakahira K, KimotoA, Nozaki M, Nishihara M, Mimura K, YamadaM, Kitajima H, Suehara N, Yanagihara I*.
Placental features of chorioamnionitis colonizedwith Ureaplasma species in preterm delivery.
Pediatric Research, 67(2), pp166-72, 2010
Hamada D, Hamaguchi M, Suzuki KN, Sakata I,
Yanagihara I. Cytoskeleton-modulating
effectors of enteropathogenic andenterohemorrhagic Escherichia coli: a case forEspB as an intrinsically less-ordered effector.
FEBS J, 277(11), pp2409-15, Review, 2010
Mimura K, Tomimatsu T, Sharentuya N,
Tskitishvili E, Kinugasa-Taniguchi Y,
Kanagawa T, Kimura T. Nicotine restoresendothelial dysfunction caused by excess sFlt1
and sEng in an in vitro model of preeclamptic
vascular endothelium: a possible therapeuticrole of nicotinic acetylcholine receptor (nAChR)

agonists for preeclampsia. Am J Obstet Gynecol.
202(5), pp464.e1-6. 2010
㪈㪇㪀 Kinugasa-Taniguchi Y, Tomimatsu T, Mimura
K, Kanagawa T, Shimoya K, Murata Y, Kimura
T. Human C-reactive protein enhances
vulnerability of immature rats tohypoxic-ischemic brain damage: a preliminary
study. Reprod Sci. 17(5), pp419-25. 2010㪈㪈㪀 Sharentuya N, Tomimatsu T, Mimura K,
Tskitishvili E, Kinugasa-Taniguchi Y, Kanagawa
T, Kimura T. Nicotine suppresses interleukin-6
production from vascular endothelial cells: apossible therapeutic role of nicotine forpreeclampsia. Reprod Sci. 17(6), pp556-63. 2010
㪈㪉㪀 Tskitishvili E, Sharentuya N, Temma-Asano K,
Mimura K, Kinugasa-Taniguchi Y, Kanagawa
T, Fukuda H, Kimura T, Tomimatsu T, Shimoya
K. Oxidative stress-induced S100B protein fromplacenta and amnion affects soluble Endoglin
release from endothelial cells. Mol Hum Reprod.
16(3), pp188-99. 2010㪈㪊㪀 ᯅᧄඳ‫ޔ‬ጊᩮദ‫ޔ‬ᳰญḩᓼ‫ޔ‬ਛᐔਭ⟤ሶ‫ޔ‬ᩉේᩰ㧚‫ޟ‬⣺Ἳࡆࡉ࡝ࠝ߇↥↢ߔࠆ⠴ᾲᕈṁⴊᲥ TDH ߩ᭴ㅧߣᯏ⢻‫ޠ‬. ᣣᧄ⚿᥏ቇળ⹹‫ޔ‬52, 285-289, 2010㪈㪋㪀 ਛጊ⡡৻ᦶ䇮ਛጊ㓷ᒄ䇮๧᧛๺຦䇮శ↰ା᣿.㩷
䇸ᅧᆼ㜞ⴊ࿶∝୥⟲䈱∛ᘒ⸃᣿㵩ಽሶᯏ᭴䉕ਛᔃ䈮㵩⢝⋚䈎䉌䉂䈢ᅧᆼ㜞ⴊ࿶∝୥⟲䇹㪅㩷 ↥ᇚੱ⑼䈱ታ㓙䇮㪌㪐㪃㩷㪈㪇㪇㪌㪄㪈㪇㪈㪈㪃㩷㪉㪇㪈㪇㪉㪅 ቇળ⊒⴫㩷㪈㪀 ᄥ↰ዊ⊖ว‫ޔ‬ች᧛ᶈᓼ‫⷏ޔ‬Ỉᤐ♿‫ޔ‬Ⓑ၂ᢥ㚅‫ޔ‬ᳯ⨲ᖘ⟤‫↰⮮ޔ‬ን㓶‫ޔ‬ᩉේᩰ‫ޔ‬ቝ↰Ꮉᐽඳ‫ޔ‬ୖᯅᶈ᮸㧚‫ޟ‬⠌ᘠᵹ↥ߦ߅ߌࠆࠕࡀࠠࠪࡦ
A5 ㆮવሶᄙဳߩᬌ⸛‫ ╙ޔޠ‬33 ࿁ᣣᧄಽሶ↢‛ቇળᐕળ‫ ╙ޔ‬83 ࿁ᣣᧄ↢ൻቇળᄢળวหᄢળ‫ޔ‬2010.12.7́10‫␹ޔ‬ᚭ‫࡯࠲ࠬࡐޔ‬㪉㪀 ᩉේᩰ‫ޔ‬ਛᐔਭ⟤ሶ‫ޔ‬ᄢ⷏♿㓁ਭ‫↰ᧄޔ‬ᱞม㧚‫ޟ‬⣺Ἳࡆࡉ࡝ࠝߩ↥↢ߔࠆ TDH ߩ᭴ㅧቇ⊛⸃ ᨆ ‫ ╙ ޔ ޠ‬83 ࿁ ᣣ ᧄ ⚦ ⩶ ቇ ળ ✚ ળ ‫ޔ‬2010.3.27-29‫ޔ‬ᮮᵿ‫ࡊ࠶࡚ࠪࠢ࡯ࡢޔ‬ญṶ&ࡐࠬ࠲࡯㪊㪀 ᩉේᩰ‫ޔ‬ਛᐔਭ⟤ሶ‫ޔ‬ᄢ⷏♿㓁ਭ‫⌀ޔ‬ᩉᶈᄥ‫ޔ‬ᯅᧄඳ‫↰ᧄޔ‬ᱞม㧚‫ޟ‬⣺Ἳࡆࡉ࡝ࠝߩ↥↢ߔࠆ thermostable direct hemolysin㧔㨀㧰㧴㧕ߩ᭴ㅧቇ⊛⸃ᨆ‫ ╙ޔޠ‬57 ࿁࠻ࠠࠪࡦࠪࡦࡐࠫ181

࠙ࡓ‫ޔ‬2010㧚7㧚14-16‫ޔ‬ᄢᵤ‫࡞࡜࡯ࠝޔ‬㪋㪀 ᩉේᩰ㧚‫ࡑ࠭࡜ࡊࠕ࡟࠙ޟ‬ᗵᨴ ̆ᵹᣧ↥ߘߒߡᰴ਎ઍ߳ߩᓇ㗀̆‫ ╙ޔޠ‬37 ࿁ᣣᧄࡑࠗ
ࠦࡊ࡜࠭ࡑቇળ 2010.6.10-11‫᧲ޔ‬੩‫ࡦࠪޔ‬ࡐࠫࠬ࠻㪌㪀 ർፉඳਯ‫ޔ‬ᩉේᩰ㧚‫ࡑ࠭࡜ࡊࠕ࡟࠙ޟ‬ᗵᨴᣧ↥⢝⋚ߦ߅ߌࠆ⛐Ძ⤑⟠⤑Ἳߩ∛ℂ௝‫ޔޠ‬ㄭ⇰⣺▤ᓸ↢‛⎇ⓥળ‫ޔ‬2010.6.5‫ޔ‬ᄢ㒋‫ޔ‬ญṶ㪍㪀 ᩉේ ᩰ㧚‫ޟ‬LPS ⺃ዉᕈᣧ↥ࡕ࠺࡞ࡑ࠙ࠬߦኻߔࠆ࠴ࠝ࡟࠼ࠠࠪࡦߩ᦭ലᕈ‫ޔޠ‬੩ㇺᄢቇ࠙ࠗ࡞ࠬ⎇ⓥᚲࡒ࠾ࠪࡦࡐࠫ࠙ࡓ࡟࠼࠶ࠢ
ࠬ↢๮ක⑼ቇߩዷᦸ㧔ATL Allergy TRX㧕‫ޔ‬
2010.3.15‫ޔ‬੩ㇺ‫ޔ‬᜗ᓙ⻠Ṷ㪎㪀 ౝ↰⮍‫ޔ‬ᷡ᳓㓉‫ޔ‬ᩉේᩰ㧚‫ޟ‬ᅧᆼࡑ࠙ࠬࠍ↪
޿ ߚ Ureaplasma parvum ↱ ᧪ multiple
banded antigen (MBA) ߦࠃࠆ⢝ౝἻ∝ᗖ⿠ᯏ᭴ߩ⸃᣿‫ ╙ޔޠ‬37 ࿁ᣣᧄࡑࠗࠦࡊ࡜࠭ࡑቇળ‫ޔ‬2010.6.10-11‫᧲ޔ‬੩‫࡞࡜࡯ࠝޔ‬㪏㪀 ౝ↰⮍‫ޔ‬㊁ፒ᣽ବ‫ޔ‬ᩉේᩰ㧚‫ޟ‬ᅧᆼࡑ࠙ࠬࠍ
↪޿ߚ Ureaplasma parvum ߦࠃࠆ⢝ౝἻ∝ᗖ⿠ᯏ᭴ߩ⸃᣿ࠍ⋡ᜰߒߡ‫ ╙ޔޠ‬46 ࿁ᣣᧄ๟↥ᦼ࡮ᣂ↢ఽකቇળ✚ળ‫ޔ‬2010.7.11㧙13‫␹ޔ‬ᚭ‫࡯࠲ࠬࡐ&࡞࡜࡯ࠝޔ‬㪐㪀 ๧᧛๺຦‫↰⮮ޔ‬ን㓶‫ޔ‬ਛጊ㓷ᒄ‫ޔ‬శ↰ା᣿‫ޔ‬ᩉේᩰ㧚‫ޟ‬ᒰ࠮ࡦ࠲࡯ߩේ࿃ਇ᣿ਇ⢒∝ᖚ⠪ߦ߅ߌࠆ 1st trimester ᵹ↥ᬌ૕ߩ∛ℂቇ⊛ᚲ⷗ߩಽ㘃‫ ╙ޔޠ‬46 ࿁ᣣᧄ๟↥ᦼ࡮ᣂ↢ఽකቇળ✚ળ‫ޔ‬2010.7.11㧙13‫␹ޔ‬ᚭ‫࡞࡜࡯ࠝޔ‬&ࡐࠬ࠲࡯㪈㪇㪀 ᅏጊብ⤿‫ޔ‬ᷡ᳓⟵ਯ‫ޔ‬૒‫ᧁޘ‬㓉჻‫ޔ‬ౝ↰⮍‫ޔ‬ᩉේᩰ‫ޔ‬Ⓑ᧛᣹㧚‫ޟ‬⢝ఽᶖൻ▤ߦ߅ߌࠆࠨ࡯ࡈ ࠔࠢ࠲ࡦ࠻Ⱞ⊕⾰ A ߣ D ߩዪ࿷ߣ↥↢ߦ㑐ߔࠆᬌ⸛‫ ╙ޔޠ‬46 ࿁ᣣᧄ๟↥ᦼ࡮ᣂ↢ఽකቇળ✚ળ‫ޔ‬2010.7.11㧙13‫␹ޔ‬ᚭ‫࡜࡯ࠝޔ‬࡞&ࡐࠬ࠲࡯
㪈㪈㪀 ㊁ፒ᣽ବ‫ޔ‬㔍ᵄᢥᒾ‫ޔ‬ౝ↰⮍‫⷏ޔ‬ේᱜᵏ‫ޔ‬ᩉේᩰ㧚‫ޟ‬Lipopolysaccharide(LPS)⺃⊒ᣧ↥ࡕ࠺࡞ࡑ࠙ࠬߦ߅ߌࠆ࠴ࠝ࡟࠼ࠠࠪࡦ㧔TRX㧕ߩᣧ↥ᛥ೙ലᨐ‫ ╙ޔޠ‬46 ࿁ᣣᧄ๟↥ᦼ࡮ᣂ↢ఽකቇળ✚ળ‫ޔ‬2010.7.11㧙13‫␹ޔ‬ᚭ‫ࠬࡐޔ‬࠲࡯
㪈㪉㪀 ㊁ፒ᣽ବ‫ޔ‬ᩉේᩰ‫଻❐ޔ‬ᐕ‫ޟ‬bHLH ォ౮࿃ሶ
E2A ߦࠃࠆ V2 ㆮવሶౣ᭴ᚑߩ೙ᓮᯏ᭴‫ޔޠ‬╙ 20 ࿁ Kyoto T cell Conference‫ޔ‬2010.6.4-5‫ޔ‬੩ㇺ‫࡞࡜࡯ࠝޔ‬㪈㪊㪀 ች᧛ᶈᓼ‫⷏ޔ‬Ỉᤐ♿‫ޔ‬Ⓑ၂ᢥ㚅‫ޔ‬ᳯ⨲ᖘ⟤‫ޔ‬182⮮↰ን㓶‫ޔ‬ᩉේᩰ‫ޔ‬ቝ↰Ꮉᐽඳ‫ୖޔ‬ᯅᶈ᮸㧚‫ ࡦࠪࠠࡀࠕޟ‬A5 ㆮવሶᄙဳߣ⠌ᘠᵹ↥ߩ㑐ㅪ ‫ ╙ ޔ ޠ‬55 ࿁ ᣣ ᧄ ੱ 㘃 ㆮ વ ቇ ળ ✚ ળ ‫ޔ‬2010.10.28-30‫ޔ‬ᄢች‫࡯࠲ࠬࡐޔ‬㪈㪋㪀 ๧᧛๺຦.‫⌕≹ޟ‬⢝⋚ߦ߅ߌࠆ࠻ࡠࡎࡉ࡜ࠬ࠻ଚ౉ⷙቯ࿃ሶߩ⸃ᨆ‫ ╙ޔޠ‬62 ࿁ᣣᧄ↥⑼
ᇚੱ⑼ቇળ‫ޔ‬2010.4.23-25‫᧲ޔ‬੩‫࡯࠲ࠬࡐޔ‬㪈㪌㪀 Hiroshi Hashimoto, Kumiko Nakahira, Tsutomu
Yamane, Takashi Fukui, Kiyouhisa Ohnishi,
Toshiyuki Shimizu, Takeshi Honda, Mitsunori
Ikeguchi, Mamoru Sato, Itaru Yanagihara.
‫ ޟ‬Structural study of thermostable direct
hemolysin from Vibrio parahaemolyticus‫ޔޠ‬ᣣᧄ↢‛‛ℂቇળ✚ળ‫ޔ‬2010㧚9-20-22‫ޔ‬઄บ‫ޔ‬ࡐࠬ࠲࡯㪈㪍㪀 Masatoshi Nozaki, Nobuyuki Tamaki, ShujiSakamoto, Itaru Yanagihara, Yasutoshi Agata.
‫ޟ‬Regulation of VJ2 gene rearrangement by thehelix-loop-helix protein, E2A‫ޠ‬14th International
Congress of Immunology‫ޔ‬2010.8.22-17‫␹ޔ‬ᚭ‫ޔ‬ࡐࠬ࠲࡯㪈㪎㪀 Itaru Yanagihara, ‫ޟ‬The pathological findings
and molecular mechanisms of Ureaplasma spp.
infection in preterm delivery ‫ ޠ‬7th European
Society for Infectious Diseases in Obstetrics andGynaecology (ESIDOG), 2010.10.2-5, Trieste,Italy, Invited Speaker㪈㪏㪀 Mitsuhide Hamaguchi, Yoshinori Murao,
Masahiro Tanaka, Noriko Tsuda, Toshihumi
Uejima,Katsuyuki
Maruyama,
Itaru
Yanagihara, Ikuhiro Sakata. ‫ ޟ‬The mRNA
expression of fatty acid amide hydrolase in
human whole blood may correlate with recovery
in patients with sepsis‫  ╙ޠ‬࿁ᣣᧄᢇᕆකቇળቇⴚ㓸ળ‫᧲ޔޔ‬੩‫࡯࠲ࠬࡐޔ‬㩷䌈䋮⍮⊛⽷↥ᮭ䈱಴㗿䊶⊓㍳⁁ᴫ㩷䋨੍ቯ䉕฽䉃䇯䋩㩷㪈㪅 ․⸵ขᓧ㩷 ․⸵౏㐿 㧙‫ޔ‬ᶰ੗ᷕม‫ޔ‬ਃᶆ⟤᮸ሶ‫ޔ‬ᩉේᩰ‫ޔ‬㔍ᵄᢥᒾ‫ޔ‬ਛᐔਭ⟤ሶ㧚Უ૕ᛩਈ↪⮎ታ↪ᣂ᩺⊓㍳㩷 ․⸵౏㐿 2008-81467
᫃㊁ീ‫⑔ޔ‬᎑༑┨‫ޔ‬ጤ੗ⷡม‫↰᧻ޔ‬㓷ᢅ‫ޔ‬ự↰ᄢਃ‫ޔ‬ᩉේᩰ㧚ੱᎿ⊛ߦ⥄Ꮖ⚵❱⢻߇ઃਈߐࠇߚวᚑ࠲ࡦࡄࠢ⾰෸߮ߘߩⶄว૕ਗ߮ߦⶄว૕ߩ⵾ㅧᣇᴺ䋲䋮䈠䈱ઁ㩷㩷㩷㩷㩿㪈㪀㩷 ⮮↰଻ஜⴡ↢ᄢୖᯅᶈ᮸䇮Უሶ䉶䊮䉺䊷⎇ⓥᚲᩉේᩰ䉌䇮䇸⠌ᘠᵹ↥䈱ㆮવሶ⊒⷗䇹㪉㪇㪈㪈㪆㪇㪉㪆㪇㪉 Ფᣣᣂ⡞㩷 ᦺೀ䇮ਛᣣᣂ⡞㩷 ᦺೀ䇮ᦺᣣᣂ⡞㩷 ᦺೀ㩷㫎㪼㪹㩷㫇㪸㪾㪼㩷ᣣᧄ⚻ᷣᣂ⡞䇮ᦺᣣᣂ⡞䇮Ფᣣᣂ⡞䇮ਛᣣᣂ⡞䇮㪋㪎㪥㪜㪮㪪䋨౒หㅢା䋩䇮᧲੩ᣂ⡞䇮ᄢ㒋ᣣᣣᣂ⡞䇮੩ㇺᣂ⡞䇮䈠䈱ઁ㩷㩿㪉㪀ᩉේᩰ䇮ᯅᧄඳ䋮ടᾲ䈚䈩䉅ᶖ䈋䈭䈇䇮㘩ਛᲥේ࿃⩶䊶⣺Ἳ䊎䊑䊥䉥䈱Ქᕈ䈮ㄼ䉏䋣䋣䇸㪪㪧㫉㫀㫅㪾㪄㪏㩷㪥㪜㪮㪪䇹㩷 㪌㪌 ภ䈱䇸⎇ⓥᚑᨐ䊶䊃䊏䉾䉪䉴ᰣ䇹㪉㪇㪈㪈 ᐕ㪊 ᦬ภឝタ੍ቯ㩷㩿㪊㪀ᩉේᩰ䇮ᧄ↰ᱞม䋮䇸ടᾲ䈪ౣ䈶Ქᕈ䇹䈱⻘⸃᣿‫ᦺޔ‬ᣣᣂ⡞⑼ቇᰣ‫ޔ‬㩿㪋㪀ᩉේᩰ‫ޔ‬ᯅᧄඳ‫↰ᧄޔ‬ᱞม㧚‫ޟ‬㘩ਛᲥේ࿃⩶ߩ
⣺Ἳࡆࡉ࡝ࠝߩᲥᕈߪടᾲߒߡ߽ߥߗᶖ߃ߥ޿ߩ߆㧫 㧙⣺Ἳࡆࡉ࡝ࠝߩ⠴ᾲᕈṁⴊᲥ
㧔6&*㧕ߩ᭴ㅧ⸃᣿‫ޠ‬52TKPI ࡎ࡯ࡓࡍ࡯ࠫ‫ޔ‬ࡊ࡟ࠬ࡝࡝࡯ࠬ࠻ࡇ࠶ࠢࠬ‫ޔ‬http://www.spring8.or.jp/ja/news_publications/press_release/2010/100521
㩿㪌㪀ᩉේᩰ䋮䇸㘩ਛᲥ䈱ේ࿃䇮⣺Ἳ䊎䊑䊥䉥䌾ടᾲ䈚䈩䉅Ქ䈏ᶖ䈋䈭䈇ℂ↱䌾䇹䇮᠞⏴⑼ቇ౏࿦ㇺᏒ䊶
⎇ⓥᦨ೨✢ 㪉㪏䇮䊋䊮䉦䊦䋨␹ᚭᣂ⡞䋩䇮㪎㪎 ⑺ภ䇮㫇㫇㪎㪋㪄㪎㪎䇮㪉㪇㪈㪇㩷㩿㪌㪀ᩉේᩰ䋮䇸ടᾲ䈜䉎䈫Ქᕈ䈏ᚯ䉎ਇᕁ⼏䈭⩶䋺ᗵᨴ∝䈫ἴኂ䋨䋲䋩䇹䇮䉝䊏䉺䊦䇮䉣䊙䊷䉳䉢䊮䉲䊷䊶䉮䊷䊦䇮ᦺᣣᣂ⡞䊖䊷䊛䊕䊷䉳 㪸㫊㪧㪸㫉㪸 䉪䊤䊑䇮㪉㪇㪈㪇㪅㪍㪅㪉㪍㩷 㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷183184185186㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷⎇ⓥᚑᨐ䈱ೀⴕ䈮㑐䈜䉎৻ⷩ⴫㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㔀⹹㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷⊒⴫⠪᳁ฬ㩷⺰ᢥ䉺䉟䊃䊦ฬ㩷⊒⴫⹹ฬ㩷Ꮞภ㩷䊕䊷䉳㩷㪤㫀㫐㪸㫄㫌㫉㪸㩷㪟㪃㩷㪥㫀㫊㪿㫀㫑㪸㫎㪸㩷㪟㪃㩷㪦㫋㪸㩷㪪㪃㩷㪪㫌㫑㫌㫂㫀㩷㪤㪃㩷 㩷㪠㫅㪸㪾㪸㫂㫀㩷㪘㪃㩷㪜㪾㫌㫊㪸㩷㪟㪃㩷 㩷㪧㫆㫃㫐㫄㫆㫉㫇㪿㫀㫊㫄㩷㫀㫅㩷㪸㫅㫅㪼㫏㫀㫅㩷㪘㪌㪥㫀㫊㪿㫀㫐㪸㫄㪸㩷㪪㪃㩷㪢㪸㫋㫆㩷㪫㪃㩷㪤㫆㫃㪼㪺㫌㫃㪸㫉㩷㪾㪼㫅㪼㩷㫇㫉㫆㫄㫆㫋㪼㫉㩷㫀㫅㩷㪡㪸㫇㪸㫅㪼㫊㪼㩷㪧㫉㫐㫆㫉㪄㪣㫆㫀㫊㪿㫀㩷㪢㪃㩷 㩷㪟㫌㫄㪸㫅㩷㩷㩷㫎㫆㫄㪼㫅㩷㫎㫀㫋㪿㩷㫉㪼㪺㫌㫉㫉㪼㫅㫋㩷㪥㪸㫂㪸㫅㫀㫊㪿㫀㩷㪠㪃㩷㪝㫌㫁㫀㫋㪸㩷㪫㪃㩷㪩㪼㫇㫉㫆㪻㫌㪺㫋㫀㫆㫅㪅㫇㫉㪼㪾㫅㪸㫅㪺㫐㩷㫃㫆㫊㫊㪅㩷㪰㫄㪸㫐㫆㫊㪿㫀㩷㪰㪃㩷㪤㪸㫉㫂㫆㪽㪽㩷㪘㪃㩷 㩷㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪠㪃㩷 㩷㪬㪻㪸㪾㪸㫎㪸㩷㪰㪃㩷㪢㫌㫉㪸㪿㪸㫊㪿㫀㩷㪟㪅㩷㪥㫆㫑㪸㫂㫀㩷㪤㪃㩷㪮㪸㫂㪸㪼㩷㪢㪃㩷㪩㪼㪾㫌㫃㪸㫋㫀㫆㫅㩷㫆㪽㩷㪫㩷㪺㪼㫃㫃㩷㫉㪼㪺㪼㫇㫋㫆㫉㩷㪫㪸㫄㪸㫂㫀㩷㪥㪃㩷㪪㪸㫂㪸㫄㫆㫋㫆㩷㪪㪃㩷 㩷㪭J㪉㩷㪾㪼㫅㪼㩷㫉㪼㪸㫉㫉㪸㫅㪾㪼㫄㪼㫅㫋㩷㪹㫐㩷 㪠㫅㫋㪼㫉㫅㪸㫋㫀㫆㫅㪸㫃㩷㪦㪿㫅㫀㫊㪿㫀㩷㪢㪃㩷 㪬㪼㫁㫀㫄㪸㩷㪫㪃㩷㩷㩷㫋㪿㪼㩷㪟㪼㫃㫀㫏㪄㪣㫆㫆㫇㪄㪟㪼㫃㫀㫏㩷㫇㫉㫆㫋㪼㫀㫅㪃㩷 㪠㫄㫄㫌㫅㫆㫃㫆㪾㫐㪤㫀㫅㪸㫋㫆㩷㪥㪃㩷㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪠㪁㪃㩷 㩷㪜㪉㪘㪅㩷㪘㪾㪸㫋㪸㩷㪰㪅㩷㪩㪼㫃㪸㫋㫀㫆㫅㫊㪿㫀㫇㩷㪹㪼㫋㫎㪼㪼㫅㩷㪿㪼㪸㫋㪄㫀㫅㪻㫌㪺㪼㪻㩷㪽㫀㪹㫉㫀㫃㫃㫆㪾㪼㫅㫀㪺㫀㫋㫐㩷㪦㪿㫅㫀㫊㪿㫀㩷㪢㪃㩷㪥㪸㫂㪸㪿㫀㫉㪸㩷㪢㪃㩷㪸㫅㪻㩷㪿㪼㫄㫆㫃㫐㫋㫀㪺㩷㪸㪺㫋㫀㫍㫀㫋㫐㩷㫆㪽㩷㪝㪜㪤㪪㩷㪬㫅㫑㪸㫀㩷㪪㪃㩷 㪤㪸㫐㪸㫅㪸㪾㫀㩷㪢㪃㩷㩷㩷㫋㪿㪼㫉㫄㫆㫊㫋㪸㪹㫃㪼㩷㪻㫀㫉㪼㪺㫋㩷㪤㫀㪺㫉㫆㪹㫀㫆㫃㫆㪾㫐㩷㪟㪸㫊㪿㫀㫄㫆㫋㫆㩷㪟㪃㩷 㩷㪿㪼㫄㫆㫃㫐㫊㫀㫅㩷㪸㫅㪻㩷㪸㩷㫉㪼㫃㪸㫋㪼㪻㩷㫃㪼㫋㫋㪼㫉㫊㩷㪟㫆㫅㪻㪸㩷㪫㪃㩷㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪠㪁㩷㪿㪼㫄㫆㫃㫐㫊㫀㫅㩷㫆㪽㩷㪭㫀㪹㫉㫀㫆㩷㫇㪸㫉㪸㪿㪸㪼㫄㫆㫃㫐㫋㫀㪺㫌㫊㪅㩷㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪠㪁㪃㩷㪥㪸㫂㪸㪿㫀㫉㪸㩷㪢㪃㩷㪰㪸㫄㪸㫅㪼㩷㪫㪃㩷㪢㪸㫀㪼㪻㪸㩷㪪㪃㩷㪪㫋㫉㫌㪺㫋㫌㫉㪼㩷㪸㫅㪻㩷㪽㫌㫅㪺㫋㫀㫆㫅㪸㫃㩷㪤㪸㫐㪸㫅㪸㪾㫀㩷㪢㪃㩷㪟㪸㫄㪸㪻㪸㩷㪛㪃㩷 㩷㪺㪿㪸㫉㪸㪺㫋㪼㫉㫀㫑㪸㫋㫀㫆㫅㩷㫆㪽㩷㪭㫀㪹㫉㫀㫆㩷 㪫㪿㪼㩷㪡㫆㫌㫉㫅㪸㫃㩷㫆㪽㩷㪝㫌㫂㫌㫀㩷㪫㪃㩷㪦㪿㫅㫀㫊㪿㫀㩷㪢㪃㩷 㩷㫇㫇㪈㪍㪉㪍㪎㪄㫇㪸㫉㪸㪿㪸㪼㫄㫆㫃㫐㫋㫀㪺㫌㫊㩷㪙㫀㫆㫃㫆㪾㫀㪺㪸㫃㩷㪉㪏㪌㩿㪉㪈㪀㩷㪢㪸㫁㫀㫐㪸㫄㪸㩷㪪㪃㩷㪪㪿㫀㫄㫀㫑㫌㩷㪫㪃㩷 㩷㪎㪋㩷㪚㪿㪼㫄㫀㫊㫋㫉㫐㩷㫋㪿㪼㫉㫄㫆㫊㫋㪸㪹㫃㪼㩷㪻㫀㫉㪼㪺㫋㩷㪪㪸㫋㫆㩷㪤㪃㩷㪠㫂㪼㪾㪸㫄㫀㩷㪫㪃㩷㪿㪼㫄㫆㫃㫐㫊㫀㫅㪅㩷 㩷㪠㫂㪼㪾㫌㪺㪿㫀㩷㪤㪃㩷㪟㫆㫅㪻㪸㩷㪫㪃㩷 㩷㪟㪸㫊㪿㫀㫄㫆㫋㫆㩷㪟㪅㩷㪥㫀㫊㪿㫀㪿㪸㫉㪸㩷㪤㪃㩷㪪㫆㫅㫆㪻㪸㩷㪤㪃㩷㪤㪸㫋㫊㫌㫅㪸㫄㫀㩷㪢㪃㩷 㩷㪡㫆㫌㫉㫅㪸㫃㩷㫆㪽㩷㪙㫀㫉㫋㪿㩷㫃㪼㫅㪾㫋㪿㩷㫀㫊㩷㪸㩷㫇㫉㪼㪻㫀㪺㫋㫆㫉㩷㫆㪽㩷㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪢㪃㩷 㩷㪧㪼㪻㫀㪸㫋㫉㫀㪺㩷㫇㫇㪐㪈㪊㪄㩷㪸㪻㫀㫇㫆㫅㪼㪺㫋㫀㫅㩷㫃㪼㫍㪼㫃㫊㩷㫀㫅㩷㪉㪊㩷㪰㫆㫅㪼㫄㫆㫋㫆㩷㪥㪃㩷㪠㪻㪸㩷㪪㪃㩷㪜㫅㪻㫆㪺㫉㫀㫅㫆㫃㫆㪾㫐㩷㪐㪉㪇㩷㪡㪸㫇㪸㫅㪼㫊㪼㩷㫐㫆㫌㫅㪾㩷㪺㪿㫀㫃㪻㫉㪼㫅㪅㩷㪥㪸㫄㪹㪸㩷㪝㪃㩷㪪㪿㫀㫄㫆㫄㫌㫉㪸㩷㪠㪃㩷㩽㩷㪤㪼㫋㪸㪹㫆㫃㫀㫊㫄㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪠㪁㪃㩷㪮㪸㪾㫌㫉㫀㩷㪤㪅㩷಴ᐕ㩷㫀㫅㩷㫇㫉㪼㫊㫊㩷㫀㫅㩷㫇㫉㪼㫊㫊㩷㫀㫅㩷㫇㫉㪼㫊㫊㩷㪉㪇㪈㪇㩷㪉㪇㪈㪇㩷187㪙㫀㫆㪺㪿㪼㫄㫀㪺㪸㫃㩷㪸㫅㪻㩷㪥㫀㫊㪿㫀㪿㪸㫉㪸㩷㪤㪃㩷㪰㪸㫄㪸㪻㪸㩷㪤㪃㩷 㩷 㪫㫉㪸㫅㫊㪺㫉㫀㫇㫋㫀㫆㫅㪸㫃㩷㫉㪼㪾㫌㫃㪸㫋㫀㫆㫅㩷㫆㪽㩷㪙㫀㫆㫇㪿㫐㫊㫀㪺㪸㫃㩷㪥㫆㫑㪸㫂㫀㩷㪤㪃㩷㪥㪸㫂㪸㪿㫀㫉㪸㩷㪢㪃㩷 㩷 㫋㪿㪼㩷 㪿㫌㫄㪸㫅㩷 㪼㫊㫋㪸㪹㫃㫀㫊㪿㫄㪼㫅㫋㩷 㫆㪽㩷㪩㪼㫊㪼㪸㫉㪺㪿㩷㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪠㪁㪅㩷㪺㫆㪿㪼㫊㫀㫆㫅㩷㪈㩷㪿㫆㫄㫆㫃㫆㪾㩷㪉㩷㪾㪼㫅㪼㪅㩷㪚㫆㫄㫄㫌㫅㫀㪺㪸㫋㫀㫆㫅㫊㩷㪥㪸㫄㪹㪸㩷㪝㪃㩷㪟㪸㫊㪼㪾㪸㫎㪸㩷㪫㪃㩷 㩷㪥㪸㫂㪸㫐㪸㫄㪸㩷㪤㪃㩷 㩷㪟㪸㫄㪸㫅㪸㫂㪸㩷㪫㪃㩷 㩷㪧㫃㪸㪺㪼㫅㫋㪸㫃㩷㪽㪼㪸㫋㫌㫉㪼㫊㩷㫆㪽㩷㪰㪸㫄㪸㫊㪿㫀㫋㪸㩷㪫㪃㩷㪥㪸㫂㪸㪿㫀㫉㪸㩷㪢㪃㩷 㪺㪿㫆㫉㫀㫆㪸㫄㫅㫀㫆㫅㫀㫋㫀㫊㩷㪺㫆㫃㫆㫅㫀㫑㪼㪻㩷㪧㪼㪻㫀㪸㫋㫉㫀㪺㩷㪢㫀㫄㫆㫋㫆㩷㪘㪃㩷㪥㫆㫑㪸㫂㫀㩷㪤㪃㩷 㩷㫎㫀㫋㪿㩷㪬㫉㪼㪸㫇㫃㪸㫊㫄㪸㩷㫊㫇㪼㪺㫀㪼㫊㩷㫀㫅㩷 㪩㪼㫊㪼㪸㫉㪺㪿㩷㪥㫀㫊㪿㫀㪿㪸㫉㪸㩷㪤㪃㩷㪤㫀㫄㫌㫉㪸㩷㪢㪃㩷㫇㫉㪼㫋㪼㫉㫄㩷㪻㪼㫃㫀㫍㪼㫉㫐㪅㩷 㩷㪰㪸㫄㪸㪻㪸㩷㪤㪃㩷㪢㫀㫋㪸㫁㫀㫄㪸㩷㪟㪃㩷 㩷㪪㫌㪼㪿㪸㫉㪸㩷㪥㪃㩷㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪠㪁㪅㩷㪚㫐㫋㫆㫊㫂㪼㫃㪼㫋㫆㫅㪄㫄㫆㪻㫌㫃㪸㫋㫀㫅㪾㩷㪼㪽㪽㪼㪺㫋㫆㫉㫊㩷㫆㪽㩷㪟㪸㫄㪸㪻㪸㩷㪛㪃㩷㪟㪸㫄㪸㪾㫌㪺㪿㫀㩷㪤㪃㩷㪼㫅㫋㪼㫉㫆㫇㪸㫋㪿㫆㪾㪼㫅㫀㪺㩷㪸㫅㪻㩷㪪㫌㫑㫌㫂㫀㩷㪢㪥㪃㩷㪪㪸㫂㪸㫋㪸㩷㪠㪃㩷 㩷㪼㫅㫋㪼㫉㫆㪿㪼㫄㫆㫉㫉㪿㪸㪾㫀㪺㩷㪰㪸㫅㪸㪾㫀㪿㪸㫉㪸㩷㪠㪅㩷㪜㫊㪺㪿㪼㫉㫀㪺㪿㫀㪸㩷㪺㫆㫃㫀㪑㩷㪸㩷㪺㪸㫊㪼㩷㪽㫆㫉㩷㪜㫊㫇㪙㩷㪸㫊㩷㪸㫅㩷㫀㫅㫋㫉㫀㫅㫊㫀㪺㪸㫃㫃㫐㩷㫃㪼㫊㫊㪄㫆㫉㪻㪼㫉㪼㪻㩷㪼㪽㪽㪼㪺㫋㫆㫉㪅㩷㪫㪿㪼㩷㪝㪜㪙㪪㩷㪡㫆㫌㫉㫅㪸㫃㩷㪊㪐㪊㩿㪈㪀㩷㫇㫇㪈㪈㪈㪄㪎㩷㪉㪇㪈㪇㩷㪍㪎㩿㪉㪀㩷㫇㫇㪈㪍㪍㪄㪎㪉㩷㪉㪇㪈㪇㩷㪉㪎㪎㩿㪈㪈㪀㩷㫇㫇㪉㪋㪇㪐㪄㪈㪌㩷㪉㪇㪈㪇㩷㪥㫀㪺㫆㫋㫀㫅㪼㩷㫉㪼㫊㫋㫆㫉㪼㫊㩷㪼㫅㪻㫆㫋㪿㪼㫃㫀㪸㫃㩷㪻㫐㫊㪽㫌㫅㪺㫋㫀㫆㫅㩷㪺㪸㫌㫊㪼㪻㩷㪹㫐㩷㪼㫏㪺㪼㫊㫊㩷㫊㪝㫃㫋㪈㩷㪸㫅㪻㩷㫊㪜㫅㪾㩷㫀㫅㩷㪸㫅㩷㪫㪿㪼㩷㪘㫄㪼㫉㫀㪺㪸㫅㩷㫀㫅㩷㫍㫀㫋㫉㫆㩷㫄㫆㪻㪼㫃㩷㫆㪽㩷㪤㫀㫄㫌㫉㪸㩷㪢㪃㩷㪫㫆㫄㫀㫄㪸㫋㫊㫌㩷㪫㪃㩷㪡㫆㫌㫉㫅㪸㫃㩷㫆㪽㩷 㩷㫇㫉㪼㪼㪺㫃㪸㫄㫇㫋㫀㪺㩷㫍㪸㫊㪺㫌㫃㪸㫉㩷㪪㪿㪸㫉㪼㫅㫋㫌㫐㪸㩷㪥㪃㩷㪫㫊㫂㫀㫋㫀㫊㪿㫍㫀㫃㫀㩷㫇㫇㪋㪍㪋㪅㪼㪈㪄㪉㪇㪉㩿㪌㪀㩷㪜㪃㩷㪢㫀㫅㫌㪾㪸㫊㪸㪄㪫㪸㫅㫀㪾㫌㪺㪿㫀㩷㪰㪃㩷 㪼㫅㪻㫆㫋㪿㪼㫃㫀㫌㫄㪑㩷㪸㩷 㫇㫆㫊㫊㫀㪹㫃㪼㩷 㪦㪹㫊㫋㪼㫋㫉㫀㪺㫊㩷㪸㫅㪻㩷㪍㩷㫋㪿㪼㫉㪸㫇㪼㫌㫋㫀㪺㩷㫉㫆㫃㪼㩷㫆㪽㩷㫅㫀㪺㫆㫋㫀㫅㫀㪺㩷 㪞㫐㫅㪼㪺㫆㫃㫃㪾㫐㩷㪢㪸㫅㪸㪾㪸㫎㪸㩷㪫㪃㩷㪢㫀㫄㫌㫉㪸㩷㪫㩷㪸㪺㪼㫋㫐㫃㪺㪿㫆㫃㫀㫅㪼㩷㫉㪼㪺㪼㫇㫋㫆㫉㩷㩿㫅㪘㪚㪿㪩㪀㩷㪸㪾㫆㫅㫀㫊㫋㫊㩷 㪽㫆㫉㩷㫇㫉㪼㪼㪺㫃㪸㫄㫇㫊㫀㪸㪅㩷㪟㫌㫄㪸㫅㩷㪚㪄㫉㪼㪸㪺㫋㫀㫍㪼㩷㫇㫉㫆㫋㪼㫀㫅㩷㪢㫀㫅㫌㪾㪸㫊㪸㪄㪫㪸㫅㫀㪾㫌㪺㪿㫀㩷㪰㪃㩷㪼㫅㪿㪸㫅㪺㪼㫊㩷㫍㫌㫃㫅㪼㫉㪸㪹㫀㫃㫀㫋㫐㩷㫆㪽㩷㪫㫆㫄㫀㫄㪸㫋㫊㫌㩷㪫㪃㩷㪤㫀㫄㫌㫉㪸㩷㪢㪃㩷㪩㪼㫇㫉㫆㪻㫌㪺㫋㫀㫍㪼㩷㫀㫄㫄㪸㫋㫌㫉㪼㩷㫉㪸㫋㫊㩷㫋㫆㩷㪈㪎㩿㪌㪀㩷 㫇㫇㪋㪈㪐㪄㪉㪌㩷㪢㪸㫅㪸㪾㪸㫎㪸㩷㪫㪃㩷㪪㪿㫀㫄㫆㫐㪸㩷㪢㪃㩷㪪㪺㫀㪼㫅㪺㪼㫊㩷㪿㫐㫇㫆㫏㫀㪺㪄㫀㫊㪺㪿㪼㫄㫀㪺㩷㪹㫉㪸㫀㫅㩷㪤㫌㫉㪸㫋㪸㩷㪰㪃㩷㪢㫀㫄㫌㫉㪸㩷㪫㪅㩷㪻㪸㫄㪸㪾㪼㪑㩷㪸㩷㫇㫉㪼㫃㫀㫄㫀㫅㪸㫉㫐㩷㫊㫋㫌㪻㫐㪅㪥㫀㪺㫆㫋㫀㫅㪼㩷㫊㫌㫇㫇㫉㪼㫊㫊㪼㫊㩷㪪㪿㪸㫉㪼㫅㫋㫌㫐㪸㩷㪥㪃㩷㪫㫆㫄㫀㫄㪸㫋㫊㫌㩷㫀㫅㫋㪼㫉㫃㪼㫌㫂㫀㫅㪄㪍㩷㫇㫉㫆㪻㫌㪺㫋㫀㫆㫅㩷㪽㫉㫆㫄㩷㪫㪃㩷㪤㫀㫄㫌㫉㪸㩷㪢㪃㩷㪫㫊㫂㫀㫋㫀㫊㪿㫍㫀㫃㫀㩷㪜㪃㩷㪩㪼㫇㫉㫆㪻㫌㪺㫋㫀㫍㪼㩷㫍㪸㫊㪺㫌㫃㪸㫉㩷㪼㫅㪻㫆㫋㪿㪼㫃㫀㪸㫃㩷㪺㪼㫃㫃㫊㪑㩷㪸㩷㪈㪎㩿㪍㪀㩷 㫇㫇㪌㪌㪍㪄㪍㪊㩷㪢㫀㫅㫌㪾㪸㫊㪸㪄㪫㪸㫅㫀㪾㫌㪺㪿㫀㩷㪰㪃㩷㪪㪺㫀㪼㫅㪺㪼㫊㩷 㩷㫇㫆㫊㫊㫀㪹㫃㪼㩷㫋㪿㪼㫉㪸㫇㪼㫌㫋㫀㪺㩷㫉㫆㫃㪼㩷㫆㪽㩷㪢㪸㫅㪸㪾㪸㫎㪸㩷㪫㪃㩷㪢㫀㫄㫌㫉㪸㩷 㪫㩷㫅㫀㪺㫆㫋㫀㫅㪼㩷㪽㫆㫉㩷㫇㫉㪼㪼㪺㫃㪸㫄㫇㫊㫀㪸㪅188㪉㪇㪈㪇㩷㪉㪇㪈㪇㩷㪉㪇㪈㪇㩷㪫㫊㫂㫀㫋㫀㫊㪿㫍㫀㫃㫀㩷㪜㪃㩷㪪㪿㪸㫉㪼㫅㫋㫌㫐㪸㩷㪦㫏㫀㪻㪸㫋㫀㫍㪼㩷㫊㫋㫉㪼㫊㫊㪄㫀㫅㪻㫌㪺㪼㪻㩷㪥㪃㩷㪫㪼㫄㫄㪸㪄㪘㫊㪸㫅㫆㩷㪢㪃㩷㪪㪈㪇㪇㪙㩷㫇㫉㫆㫋㪼㫀㫅㩷㪽㫉㫆㫄㩷㫇㫃㪸㪺㪼㫅㫋㪸㩷 㪤㫆㫃㪼㪺㫌㫃㪸㫉㩷㪤㫀㫄㫌㫉㪸㩷㪢㪃㩷㪸㫅㪻㩷㪸㫄㫅㫀㫆㫅㩷㪸㪽㪽㪼㪺㫋㫊㩷㫊㫆㫃㫌㪹㫃㪼㩷㪟㫌㫄㪸㫅㩷㪢㫀㫅㫌㪾㪸㫊㪸㪄㪫㪸㫅㫀㪾㫌㪺㪿㫀㩷㪰㪃㩷㪜㫅㪻㫆㪾㫃㫀㫅㩷㫉㪼㫃㪼㪸㫊㪼㩷㪽㫉㫆㫄㩷㪩㪼㫇㫉㫆㪻㫌㪺㫋㫀㫆㫅㪢㪸㫅㪸㪾㪸㫎㪸㩷㪫㪃㩷㪝㫌㫂㫌㪻㪸㩷㪟㪃㩷㪼㫅㪻㫆㫋㪿㪼㫃㫀㪸㫃㩷㪺㪼㫃㫃㫊㪅㩷㪢㫀㫄㫌㫉㪸㩷㪫㪃㩷㪫㫆㫄㫀㫄㪸㫋㫊㫌㩷㪫㪃㩷㪪㪿㫀㫄㫆㫐㪸㩷㪢.㩷ᯅᧄඳ䇮ጊᩮദ䇮㩷䇸⣺Ἳ䊎䊑䊥䉥䈏↥↢䈜䉎⠴ᣣᧄ⚿᥏㩷ᳰญḩᓼ䇮ਛᐔਭ⟤ሶ䇮㩷 ᾲᕈṁⴊᲥ㪫㪛㪟䈱᭴ㅧ䈫ᯏቇળ⹹㩷ᩉේᩰ䋮㩷⢻䇹㩷䇸ᅧᆼ㜞ⴊ࿶∝୥⟲䈱∛ᘒਛጊ⡡৻ᦶ䇮ਛጊ㓷ᒄ䇮 ⸃᣿㵩ಽሶᯏ᭴䉕ਛᔃ䈮㵩 ↥ᇚੱ⑼䈱
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