Through Scientific Discovery andits Application Solving the World Health
Problem

Institute of Tropical Medicine Nagasaki University
July 2017

MISSION STATEMENT
Institute of Tropical Medicine (ITM), Nagasaki University
The tropics, the most ecologically diverse region on the Earth, presents an ongoingcomplexity of tropical diseases and other health problems. In view of the remarkableadvances made in the field of international exchange in recent years, it is imperativethat these problems be addressed from a global perspective.
Based on this understanding, the Institute of Tropical Medicine, Nagasaki University,
aims to overcome tropical diseases, particularly infectious diseases, and the various
health problems associated with them, in cooperation with related institutions, to strive forexcellence in the following areas:
1. Spear-head research in tropical medicine and international health
2. Global contribution through disease control and health promotionin the tropics by applying the fruits of the research
3. Cultivation of the researchers and specialists in the above fields

General View of the Institute
Coverpage Photo : From Nha Trang branch of the Vietnam Research station at Pasteur Institute
Photographer : Kenji HirayamaPreface
Nagasaki University Institute of Tropical Medicine (ITM) was established in 1942 as a unique government-assisted
institution for research on tropical medicine, both in the basic and applied fields. The Ministry of Education, Culture,
Sports, Science and Technology (MEXT) designated ITM as a “Collaborative Institute” and a “Center of Excellence” in1982 and 1995 respectively. In 1993, the World Health Organization designated ITM a WHO Collaborating Centre for
Reference and Research on Tropical Viral Diseases. Most recently, in 2009, ITM was authorized as a “Tropical
Medicine Research Center of Joint Usage” supported by MEXT, This recognition underlines the importance of ITM as
an open institute whose resources are freely available to the whole research community. The current organization of
the institute involves four major research fields (15 departments, one domestic visiting department, one overseas
visiting department), two centres, and one clinical unit.

Developing countries in the tropics, the most ecologically and culturally diverse regions of the world, are affectedby a diverse group of tropical diseases, new emerging infectious diseases and life-style diseases. In view of theremarkable advances made in the field of international exchange in recent years, the industrialized countries of thetemperate zones are also affected by these problems and it is imperative that they are addressed from a global
perspective. Based on this paradigm, ITM aims to overcome tropical and emerging infectious diseases, and thevarious related health problems in the tropics and the rest of the world, in cooperation with related institutions, and to
strive for excellence in the following areas:

1. Spear-head research in tropical medicine and international health
2. Global contribution through disease control and health promotion in the tropics by applying the fruits of theresearch
3. Cultivation of the researchers and specialists in the above fields

This pamphlet offers a brief but hopefully intelligible explanation of our organization and its activities in research,education and other related social activities. As you will see, our research activities address traditional tropicaldiseases such as malaria, schistosomiasis, dengue fever, zika virus disease, yellow fever and acute respiratory
infections, and emerging infections such as HIV/AIDS, SARS and Ebola disease. We conduct basic, epidemiologicaland clinical research for disease prevention and control. We also investigate environmental factors including vectors,
and natural and social environments. ITM educates students in PhD and Masters courses as part of the Graduate
School of Biomedical Science and Graduate School of Tropical Medicine and Global Health of Nagasaki University. In
addition, ITM provides a three-month training course on tropical medicine. You will also find information about our
research bases in Kenya and Vietnam. Finally, the financial status of the institute is summarized.
Your suggestions, support and ideas for the further development of ITM are greatly appreciated.
May, 2017
Kenji Hirayama
Dean and Professor
Institute of Tropical Medicine (ITM)
Nagasaki University−1−

Contents
Preface������������������������������������ 1
Contents ����������������������������������� 2
Historical Review ������������������������������� 3
Successive Deans of the Institute ������������������������� 4
Organizational Chart ������������������������������ 5
The Steering Committee for the Institute of Tropical Medicine�������������� 6
Research Center on Tropical Diseases ����������������������� 7
The Steering Committee for the Collaborative Research Center on Tropical Medicine ���� 9
Character of research organization and activities ������������������ 10
Graduate Courses ������������������������������ 10
Three-month Course on Tropical Medicine �������������������� 11
Public communication ���������������������������� 11
Publications��������������������������������� 11
Department of Virology���������������������������� 12
Department of Emerging Infectious Diseases�������������������� 13
Department of Bacteriology �������������������������� 14
Department of Protozoology �������������������������� 15
Department of Parasitology �������������������������� 16
Department of Immunogenetics������������������������� 17
Department of Pathology ��������������������������� 18
Department of Eco-epidemiology ������������������������ 19
Department of International Health ����������������������� 20
Department of Vector Ecology & Environment������������������� 21
Department of Clinical Medicine ������������������������ 22
Department of Pediatric Infectious Diseases�������������������� 23
Department of Clinical Product Development ������������������� 24
Center for Infectious Disease Research in Asia and Africa
Kenya Research Station���������������������������� 25
Vietnam Research Station ��������������������������� 26
Tropical Medicine Museum �������������������������� 27
Central Laboratory������������������������������ 28
NEKKEN Bio-Resource Center (NBRC) ��������������������� 29
NTD Innovation Center ���������������������������� 30
LF-NTD Unit�������������������������������� 31
Office of Coordination for Humanitarian Affairs ������������������ 32
The University Hospital Infectious Disease Ward������������������ 33
Number of Staff ������������������������������� 34
Accounting��������������������������������� 34
Grant-in-Aid for Scientific Research from the Ministry of Education,
Culture, Sports, Science and Technology ��������������������� 34
Subsidy ���������������������������������� 35
External Fund�������������������������������� 35
Agreement of Educational, Scientific and Scholarly Exchange������������� 35
Telephone Number������������������������������ 36
Location map of the Institute of Tropical Medicine on Sakamoto Campus of Nagasaki University � 38
−2−

Historical Review

the ensuing year, the Infectious Animals Depriva-tion
Experiment Laboratory was promoted to be-comethe Animal research Center for Tropical Infections,and the second building expansion was concluded
in March, 1980. In September, 1983, a JICA-sponsoredgroup training program Tropical Medicine Research
Course was opened, the Department of Protozoology
was established a year after, and the third building
extension was finished in July the year after that. Twoyears later, the Department of Medical Entomology
was created and the Institute was reorganized into
the collaborative institute in another two years. In
1991, the Department of Biochemistry was added,
and the fourth building expansion was ended in
March, 1994. In April, 1994, the Institute was divided
into three big Divisions, Tropical Microbiology, Pathogenesis
and Clinical Sciences, and Environmental Medicine, withthe establishment of two new research Departments,
Thermal Adaptation and Social Environment, which have
expanded to 12 Departments at present. The Institute wasdesig-nated as Center of Excell-ence in the forefront ofscientific research in 1995, and a new research
Department, Molecular Epide-miology, was establishedunder the Research Field of Microbiology in 1996 to
invite overseas visiting professors. In 1997, the Reference
Room for the Tropical Medicine was replaced by the
Tropical Disease Information and Reference Center, andit was again succeeded by the Research Center for
Tropical Infectious Disease in 2001. In March, 2003,
when the Sakamoto build-ing finalized its fifth expansion,
its extension work of almost 40 years came to an end. In
March, 2006, the main building’s repair work wascompleted. In April, 2008, the Research Center for
Tropical Infectious Disease for the Tropical Medicine was
replaced by the Center for Infectious Disease Researchin Asia and Africa and Tropical Medicine Museum. In
June, 2009, the institute was authorized as the
Collaborative Research Center on Tropical Diseaseby the Ministry of Education. More recently, three
additional depatments i.e., clinical medicine, pediatricinfectious diseases and clinical pharmaceutical science,
were admitted for installation.
In June, 2013, the Animal Research Center for
Tropical Infections was closed.
In April, 2014, Tropical Medicine Museum was
relocated.

The Institute of Tropical Medicine, Nagasaki
University was originally founded in March 1942 as
the East Asia Research Institute of Endemics,
Nagasaki Medical College in order to perform basic
and applied studies on endemic diseases in East
Asia. At the beginning, most of its research activities
were field studies conducted in mainland China by
the Departments of Pathology, Bacteriology, Internal
Medicine, and Dermatology of Nagasaki Medical
College. August 9th, 1945, the atomic bomb was
dropped in Nagasaki, and the Institute’s all the facilities
and research materials were completely destroyed
together with Medical School. Consequently, thedevelopment of the Institute and its research activities
had lagged significantly behind.
In April, 1946, the Institute changed its name to
the Research Institute of Endemics, Nagasaki Medical
College, and moved to Isahaya City in May to resume
research activities. Yet in accordance with the National
School Establishment Law issued in May, 1949, theInstitute once again changed its name to the ResearchInstitute of Endemics, Nagasaki University. In 1957,
the Institute was affected by another disaster of massive
flooding, and its facilities, equipment, and researchmaterials were severely damaged. Thus, constructionof a new building started in Sakamoto, Nagasaki City in
1960, and the Institute moved to the building in April ofthe following year. The Institute’s Departments, whichwere only two at the time, Pathology and Clinics, increased
its number every year after 1963, including Epidemiology,
Parasitology, and Virology. The Sakamoto building
finished its first expansion at the end of 1966.
In June, 1967, with the partial alteration of the National
School Establishment Law, the name of the Institute waschanged for the third time to the present one to carry out
basic and applied studies on tropical medicine. Aroundthe same time, the Department of Internal Medicine,
Institute of Tropical Medicine, equipped with 20 beds, wasopened in the University Hospital. In 1974, the Departmentof Bacteriology and the Reference Center wereattached, and in 1978, the Department of Preventive
Medicine, consisting mainly of visiting professors,
associate professors, and researchers, and theTropical Medicine Training Course were launched. In−3−

Successive Deans of the Institute(East Asian Research Institute of Endemics)
Susumu Tsunoo

May. 4, 1942 - Aug. 22, 1945

Kohei Koyano

Dec. 22, 1945 - Jan. 23, 1948

Kiyoshi Takase

Jan. 24, 1948 - Aug. 31, 1948

Noboru Tokura

Sept. 1, 1948 - May. 30, 1949

(Research Institute of Endemics)
Noboru Tokura

May. 31, 1949 - Aug. 31, 1958

Nanzaburo Omori

Sept. 1, 1958 - Nov. 30, 1963

Hideo Fukumi

Dec. 1, 1963 - May. 31, 1967

(Institute of Tropical Medicine)
Hideo Fukumi

Jun.

Daisuke Katamine

Dec. 1, 1969 - Nov. 30, 1973

Kaoru Hayashi

Dec. 1, 1973 - Nov. 30, 1977

Tatsuro Naito

Dec. 1, 1977 - Nov. 30, 1979

Daisuke Katamine

Dec. 1, 1979 - Apr.

1, 1981

Keizo MatsumotoApr.

2, 1981 - Apr.

1, 1991

Hideyo Itakura

Apr.

2, 1991 - Apr.

1, 1993

Mitsuo Kosaka

Apr.

2, 1993 - Apr.

1, 1997

Akira Igarashi

Apr.

2, 1997 - May. 31, 2001

Yoshiki Aoki

Apr.

1, 2001 - May. 31, 2007

Kenji Hirayama

Apr.

1, 2007 - May. 31, 2011

Tsutomu TakeuchiApr.

1, 2011 - May. 31, 2013

Kouichi Morita

Apr.

1, 2013 - May. 31, 2017

Kenji Hirayama

Apr.

1, 2017 - Up to the present−4−

1, 1967 - Nov. 30, 1969

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0GmDFPG$PPSEJOBUJPOGPS)VNBOJUBSJBO"GGBJST/BHBTBLJ6OJWFSTJUZ)PTQJUBM*OUFSOBM.FEJDJOF%FQBSUNFOUPG*OGFDUJPOT%JTFBTFT−5−The Steering Committee for the Institute of Tropical Medicine
Committee Member outside the university
National Institute of Infectious Diseases

Director-General

Ichiro Kurane

Department of Tropical Medicine and Malaria Research
Director

Shigeyuki Kano

Disease Control and Prevention Center

Director

Hokkaido University Research Center for Zoonosis Control

Norio Ohmagari

Specially Appointed Professor

Obihiro University of Agriculture and Veterinary Medicine

Executive Vice President, Director

National Institute for Environmental Studies

President

Tohoku University Graduate School of Medicine

Professor

Noboru Inoue
Chiho Watanabe
Hitoshi Oshitani

Dean

Hiroyoshi Endo

Nagasaki University

Trustee

Graduate School of Biomedical Sciences

Dean

School of Tropical Medicine and Global Health

Dean

Atomic Bomb Disease Institute

Dean

Syunichi Yamashita
Isao Shimokawa
Kiyoshi Kita
Yasushi Miyazaki

Institute National Center for Global Health and Medicine
National Center for Global Health and Medicine

Chihiro Sugimoto

St. Luke’s International University
Graduates School of Public HealthCommittee Member outside the instituteCommittee Member inside the institute
Institute of Tropical Medicine

Dean

Institute of Tropical Medicine

Vice-Dean

Institute of Tropical Medicine

Vice-Dean◎Kenji Hirayama
Shinjiro Hamano
Osamu Kaneko◎:Chairman−6−Research Center on Tropical Diseases
Our institute is the one and only public sector
supported by MEXT (Ministry of Education, Culture,
Sports, Science and Technology, Japan) that aims
to do the research on tropical diseases, and identified
as the Collaborative Research Center on Tropical
Disease.

appeals to the public for the research meeting, which
promotes and facilitates the research of infectious
diseases through exchanging information or technologies
necessary. The Research Center on Tropical Medicine
is also to deliver bio-resources including infectious
agents, information, and etc. collected and stored
here, and thus serves as a resource center on
Tropical Medicine.

1. The Goal of the Center
The infectious diseases are caused by thecollapse of symbiosis with other creatures, whichcannot be avoided if we, human being, live in thenature. Although the ultimate aim of this center is toeradicate infectious diseases, it is needed rather toestablish reciprocal relationship with other creatures
than to eliminate them. Such establishment of reciprocal
relationship requires the collective knowledge, which
can be achieved only by combining a broad aspectof disciplines.
The Tropical Infectious Diseases have been
spreading in the tropical area, which is the reflectionof environment and socio-economic situation existed
there. It is considered to be a big challenge related
to health. As a matter of fact, emerging and reemerging infectious diseases including newly
emerging infectious diseases, HIV and tuberculosis
have been spreading globally with tropical area
being its epicenter. The tropical area is not only thebattle field where we, human being, fight againstthem but also the experimental ground where we
newly create and develop our knowledge andtechnology alike in order to control infectious
diseases.
The Research Center on Tropical Diseases is toaccomplish with the members in the diverse scientificcommunities collaborative researches rooted upon
the field where infectious diseases are prevailing,making use of the facilities like Asia and Africa
Research Stations internationally recognized. It
also serves as a resource center for information andbiological samples related to infectious diseases
speeding globally.

3. Organizational Chart of the Center
As for administration of this research center, thedean of the Institute of Tropical Medicine establishedthe Steering Committee for the Collaborative ResearchCenter on Tropical Medicine, which was composedof 11 members, out of whom more than half should
be outside the university concerned. The Steering
Committee for the Collaborative Research Center on
Tropical Medicine is responsible for adoption of theapplications and monitoring and evaluation of theactivities in question.
In order to support activities above mentioned,
the specific section supporting the Research Center
on Tropical Medicine was newly formed and aprofessor was designated to be a section chief.
4. Applications for Collaborative Researches
There were 39 applications for collaborative
researches, out of which 27 were adopted.
There were 2 applications for collaborative
researches with overseas bases, out of which 2
were adopted.
There were 2 applications for research meeting,out of which 2 were adopted.

2. Outline of the Collaborative Research
The Research Center on Tropical Medicine
appeals to the public for the collaborative research,which is either basic or applied research based
upon epidemiological, clinical or public healthframework. The Research Center on Tropical Medicine−7−

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The Steering Committee for the Collaborative Research Center
on Tropical Medicine
Committee Member outside the university
Oita University Faculty of Medicine

Professor

National Reseach Center for Protozoan Diseases,
Obihiro University of Agriculture and Veterinary Medicine

Professor

Niigata University Graduate School of Medical and Dental Sciences
Professor◎Akira Nishizono
Shinichiro Kawazu
Sohkichi Matsumoto

Institute for Frontier Life and Medical Sciences, Kyoto University

Associate professor

National Institute of Infectious Diseases

Director

The University of Tokyo Graduate School of Medicine

Professor

National Center for Child Health and Development

Director

National Institute of Infectious Diseases

Visiting researcher

Takayuki Miyazawa
Manabu Ato
Satoshi Sasaki
Rintaro Mori
Yoshio Tsuda

Committee Member outside the institute
Professor

Katsuyuki Yui

Institute of Tropical Medicine

Professor

Institute of Tropical Medicine

Professor

Institute of Tropical Medicine

Professor

Taro Yamamoto
Koya Ariyoshi
Yoshio Ichinose

Graduate School of Biomedical Sciences

Committee Member inside the institute◎:Chairman

−9−Character of researchorganization and activities
Based on the following research organizationand intimate linkages with other research institutes
and universities, the institute aims at accomplishing a
mission: Spear-head research in tropical medicine
and international health.
●To study comprehensively the tropical diseases
which are raging in the developing countries, researchorganization of the institute consists of 4 major research
fields which deal with the classic quad of the humanagent-environment determinant-clinical study of
infectious diseases and Overseas Research Station
and Tropical Medicine Museum. Other facilities of
the institute include NTD Innovation Center, Nekken
Bio-Resource Center, Office of Coordination for
Humanitarian Affairs, a joint research laboratory, a
tropical medicine education office and LF-NTD Unit.
●The research of tropical medicine faces theinevitable fact that the bench is in the bush. Therefore
the institute has a close linkage with the overseas
institutes in Asia, Africa and South Americas andcontinues the joint studies. Memorandums ofacademic exchange programs were signed between
Nagasaki University and 14 overseas institutes. Since
the overseas research laboratories of the institute has
been established in Kenya Medical ResearchInstitute (KEMRI), Kenya and National Institute ofHygiene and Epidemiology (NIHE) Vietnam in
2005, by the grants from Ministry of Education,
Sports, Culture, Science and technology (MEXT),the extensive and longitudinal studies on tropicaldiseases has been on the progress, and areextended to continue in more 5 or 6 years. The
third term of the Vietnam project has started in2015 and Kenya project has started in 2016. We
have extended our effort to achieve external funds
for this project and obtained the Special Coordination
Funds for Promoting Science and Technology andthe Science and Technology Research Partnershipfor Sustainable Deve-lopment (SATREPS), etc.
These funds have expanded the researches at
Asia and Africa stations. At the same time, basic
research area related to Infection has been
activated by obtaining Kakenhi grants From MEXT.
●The prevalence of tropical diseases depends onthe geographic, social and economic factors.
Therefore the institute has established the special
research system which helps forward themultidisciplinary studies on tropical diseases.

Graduate Courses
1. PhD Course
Graduate School of Biomedical Sciences, Nagasaki

University now offers six master and doctoral courses,
after unification in 2002 of three biomedical schools,
Medical, Dental and Pharmacology. All the departmentsin the Institute of Tropical Medicine (ITM) are actively
involved in teaching the Course on Infection
Research. In April 2013, the “Program for Nurturing
Global Leaders in Tropical and Emerging Communicable
Diseases (PhD course)” was incorporated in thisCourse. Limited to 15 students per year, the newprogram is one of the several programs adopted by
the Program for Leading Program supported by the
Ministry of Education, Culture, Sports, Science andTechnology. It focuses on controlling tropical andemerging infectious communicable diseases and on
leadership. One of its unique features is that students
will be given practical trainings in a cross-field
curriculum, which includes hands-on training at overseas
Nagasaki University Research Stations in Kenya andVietnam and other international organizations. For the
program, twenty-one staff of ITM composed ofprofessors, associate professors and assistant professors
devote themselves in giving lectures and supervising
students’ research activities.
2. Master Courses
In April 2015, School of Tropical Medicine andGlobal Health was newly established.
The School consists of three master courses;
Tropical Medicine Course (Master of Tropical Medicine)provides the medical doctors with clinical knowledge
and academic research skill to respond to healthissues in the area of tropical medicine. (one year)
International Health Development Course (Master of
Public Health) equips the students with essential
knowledge and skills required to pursue careers ininternational health. (two years)
Health Innovation Course (Master of Science in Global
Health and Medicine) gives opportunities of basic
research skills to prepare for pursuing higher academic
careers in global health research. (two years)
The latter two courses are open to those who have no
medical/ health background.
One of the strengths is that the students of all threecourses will learn together in the basic modules on
global health so that they will have opportunities tounderstand the issues in wider perspectives thantheir own disciplines.
Other characteristics include the whole learning is
conducted in English and the academic partnership ofteaching and research with London School of Hygiene& Tropical Medicine, a leading global institute oftropical medicine
The information on PhD and master courses including
application form will be available through our webpage.
http://www.tm.nagasaki-u.ac.jp/nekken/english/index.html− 10 −

Three-month Course on
Tropical Medicine
This is a short-course of tropical medicine. This
course aims to support medical and co-medical
personnel who plan to work in the tropics, by providing
opportunities to learn a broad range of skills andknowledge relevant to practicing medicine, implementing
disease control programs and conducting medical
research in tropical and developing countries. The
course began in 1978 and since 2017, it opens to theresearchers who pursue technology for global health.
Fifteen participants are accepted to attend the course
in each year. As of the 39th course in 2016, 501
participants in total (including 181 medical doctors,
and 320 co-medical such as nurses, community
health nurses, midwives, pharmacists) from all overJapan have completed the course.
The course is run by the steering committee,
which consists of members from both inside andoutside the Institute of Tropical Medicine (ITM).
During thirteen weeks (April to June), the fulltime staff members of the ITM and a substantial
number of visiting professors and lecturers provide
lectures, laboratory practicals and field work, in thefields of virology, bacteriology, protozoology, parasitology,
medical entomology, pathology, immunogenetics,
epidemiology, human ecology, social medicine,clinical medicine and also geography and culture intropics. Participants who successfully completed thecourse are awarded the Diploma in Tropical Medicine.

Culture etc. To accumulate know-how of risk communication
on tropical infectious diseases in our institute, we areplanning to have open lectures where we have frankcommunication with citizens on the present state andfuture prospects of research on tropical medicine.

Publications
Our official publications are as follows;
1. Bulletin of Nagasaki University Institute of Tropical
Medicine (in Japanese, yearly since 1964, PDF
files are available at our web page.)
2. Japanese Brochure (in Japanese yearly since1977, PDF files are available at our web page.)
3. English Brochure: INSTITUTE OF TROPICALMEDICINE NAGASAKI UNIVERSITY (this copy.
Yearly since 1977, PDF files are available at our
web page.)
4. Report of Nation-wide Cooperative Research
Projects (Information of research activities andachievements as a nation-wile cooperative research
center for tropical medicine is compiled.)

1

2

3

4

Admission ceremony in 2017

Public communication
Lectures and film shows for citizens are heldoccasionally. Every year, several groups of highschool students with teachers visit our museum,attending lectures and film shows. In 2015, we had 5
open lectures at Nagasaki Museum of History and− 11 −

Department of Virology
This Department has been conducting basic andapplied research on arthropod-borne viruses (arboviruses)
such as Japanese encephalitis virus (JEV), dengue
virus (DENV), Zika virus, Chikungunya virus (CHIKV)
and severe fever with thrombocytopenia virus (SFTSV),
as well as emerging infectious viruses, such as SARS
virus and Nipah virus.
Molecular epidemiology of arboviruses
We isolate DENV, JEV and CHIKV in Asia andAfrican regions and conduct molecular epidemiologicalanalysis to clarify international and inter-continental
movement of these viruses. We also analyze uniquegenome sequences that are relevant to pathogenicity.

Activities as a WHO Collaborating Center
The department is designated as a WHO
Collaborating Center for Reference and Research on
Tropical Viral Diseases since 1993 and has been redesignated until the present as a center for Tropicaland Emerging Virus Diseases. The centre has beencollaborating with WHO in training WHO fellows frommany developing countries and has deployedexperts as WHO short-term consultants. The
Department initiated and held the First GOARN/WHO
National Training Course in Nagasaki from 25 to 29
February 2008 in collaboration with WHO/WPRO.

Research on viral pathogenesis and vaccine developmentusing reverse genetics
We have developed infectious clones of JEV and
DENV and identified gene functions by modifying
various parts of the genes or constructing chimericviruses. In addition, we are developing geneticallyengineered viruses as candidates for live attenuatedvaccines.
Research on the pathogenicity of arboviruses and invivo evaluation of therapeutic compounds
We elucidate the mechanism of pathogenicity
and infectivity of arboviruses, such as JEV and SFTSV
using a mouse model. We also evaluate the therapeutic
effects of antiviral drugs and antiserum in vivo. A new
dengue vaccine is under development by financial
support of GHIT.
Development of rapid diagnostic assay for infectious
diseases
Various tools for rapid diagnoses are being
developed for flaviviruses and other emerging viruses
using PCR, LAMP and nLC/MS technologies. Also,
genetically engineered antigens are being developed
to provide affordable serological tests for developing
countries.
Research on emerging viral infectious diseases
Epidemiological studies on SARS virus, Severe
Fever and Thrombocytopenia Syndrome virus (SFTS)
and H5N1 avian influenza virus are being conductedin Viet Nam, Japan and other countries in the South
East Asia.
− 12 −

Professor
Associate Professor
Associate Professor
Associate Professor(Project)
Assistant Professor
Assistant Professor
Visiting Professor
Visiting Researcher
Visiting Researcher
Visiting Researcher
Visiting Researcher
Research Fellow
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Kouichi Morita
Moi Meng Ling
Shingo Inoue
Daisuke Hayasaka
Takeshi Nabeshima
Mya Myat Ngwe Tun
Masanobu Ago
Toru Kubo
Akira Yoshikawa
Yuki Takamatsu
Reo Uchida
Muhareva Raekiansyah
Kazumi Jodai
Kimiko Taniguchi
Aung Kyaw Kyaw
Satoshi Shimada
Phu Ly Minh Huong
Bui Thu Thuy
Mark Anthony D. Luz
Nguyen Co Thach
Tsuyoshi Ando

Molecular imaging of SFTSV-infected mouseDepartment of Emerging
Infectious Diseases
Emerging infectious diseases are infectious
diseases whose incidence in humans have increasedin the past 20 years and threaten to increase in thenear future. We are working on the basic research todevelop and produce countermeasures against
emerging infectious diseases, especially viralhemorrhagic fevers and influenza.
Research subjects:
Analyses of replication mechanisms of highly pathogenic
viruses
In infected cells, the viruses replicate using
various cellular machinery and release a large
number of progeny virions. Our interests are to clarify
the molecular mechanisms of virus replication in hostcells. We are currently analyzing the molecularinteractions between viral proteins and cellular factors
in virus infected cells. Especially, we are focusing on
highly pathogenic viruses, such as Ebola, Marburg,
Lassa and Influenza viruses.

Development of detection methods for highly pathogenic
viruses
In case of outbreak of emerging infectious diseases,
rapid and accurate diagnosis is essential to control
infection and to prevent further transmission. We havedeveloped novel diagnostic assay for emerging viraldiseases.
Studies on Lassa fever in Nigeria
Lassa fever is a viral hemorrhagic fever and now
endemic in West African countries. Annually 300,000500,000 peoples are infected with Lassa virus and
5,000 patients have died in Lassa fever every year.
We are carrying on the epidemiological studies, thedevelopment of novel diagnostic methods and thepathological studies on Lassa fever in collaboration
with a Nigerian group.

Development of novel antiviral strategies
To establish novel antiviral strategies against viralhemorrhagic fevers and influenza, we are identifying
the cellular factors which have antiviral activity andanalyzing the molecular mechanisms of their antiviralaction. We will also start high-throughput screening oforganic and chemical compound libraries for antiviraldrug discovery against viral hemorrhagic fevers.

Molecular Mechanism of Marburg virus budding

Professor
Assistant Professor
Assistant Professor
Assistant Professor
Research Fellow
Research Fellow
Research Fellow
Research Fellow
Research Fellow
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Jiro Yasuda
Yohei Kurosaki
Shuzo Urata
Haruka Abe
Rokusuke Yoshikawa
Yuri Ushijima
Sayaka Okada
Mayuko Kimura
Maki Sueyoshi
Miku Takano
Saki Miyazaki
Olamide Oloniniyi Kolawole
Vahid Rajabali Zadeh
Patrick MpingaboⅠlunga
Christelle Pemba Mawonga
Ryosuke Yamashiro

Collaboration research work in the South Africa
BSL-4 facility− 13 −

Department of Bacteriology
Our major research interest is to elucidate the
etiologic agents isolated from pathogenic bacteria
related to the worldwide emerging and reemerging
diseases and to know the virulence mechanisms ofbacterial pathogens.
Helicobacter pylori is a bacterial pathogen foundin the stomach mucosa of more than 50% of the world
population and more common (over 80%) in developing
and tropical countries. Infection with H. pylori plays amajor role in the development of chronic gastritis andpeptic ulcer, and is a risk factor for gastric cancer.
Pathogenic strains of H. pylori secrete a potent protein
toxin, a vacuolating cytotoxin, termed VacA, whichcauses progressive vacuolation of epithelial cells
and gastric injury. We found that VacA induces
multiple effects on epithelial cells, including mitochondrial
damage [1] and apoptosis [2]. These actions of VacA
appear to result from activation of cellular pathways,
independent of those leading to vacuolation. Similarly,
VacA-induced phos-phorylation of G proteincoupled
receptor kinase-interactor 1 (Git 1), which may be
responsible for epithelial cell detachment caused by
VacA, leading to peptic ulceration [3], and VacAinduced activation of p 38/ATF-2- mediated signal
pathway [4] are independent of VacA effects on
cellular vacuolation.
Analysis of VacA receptors provided new insights
into the molecular basis of VacA function. We reported
that two VacA proteins, termed m1 VacA and m2
VacA, which were defined by sequence differencesin the middle of the molecules, interacted with target
cells by binding to two types of receptor-like protein
tyrosine phosphatases (RPTPs), i. e., RPTPα andRPTPβ, resulting in toxin internalization and vacuolationof the human gastric adeno-carcinoma cell lines AZ521 and G 401 [5, 6, 7]. By analysis of the pathologicalresponses of wild type and RPTPβ-deficient mice tooral administration of VacA, we found that RPTPβ
functions as a receptor for VacA and produces thedisease associated with VacA toxicity including gastritis
and gastric ulcer [3].
More recently, we purified from AZ-521 cells, ahuman gastric epithelial ell line, a surface membraneprotein, p500, which binds VacA, and identified it as
low-density lipoprotein receptor-related protein-1 (LRP1).
LRP1 binding of VacA was shown to be specifically
responsible for VacA-induced autophagy and apoptosis,
but not activation of the Wnt/β-catenin signaling pathway.
Similar to RPTPα and RPTPβ, LRP1 mediates VacA
internalization in AZ-521 cells, but in contrast to
RPTPα and RPTPβ, LRP1 targeted downstream
pathways leading to autophagy and apoptosis. VacAinduced autophagy via LRP1 binding precedes
apoptosis suggesting that an excessive autophagic
activity can also lead to cell death. This is the firststudy to provide evidence that LRP1 mediates autophagy[8]. Surprisingly, CagA, which is an oncogenic protein
injected by its type IV secretion system into host cells,
was degraded by autophagy induced by m1 VacA, but
not m2 VacA, whereas CagA in CD44v9-expressing
cancer stem-like cells escaped this autophagy system,
resulting in accumulation of CagA in cells [9].
References:[1] Microb. Pathog. 31:29-36, 2001,[2] J. Biol. Chem. 281: 11250-11259, 2006,[3] Nat. Genet. 33: 375-381, 2003,[4] J. Biol. Chem. 279: 7024-7028, 2004,[5] J. Biol. Chem. 278:19183-19189, 2003,[6] J. Biol. Chem. 279: 51013-51021, 2004,[7] Cell Microbiol 7: 1285-293, 2005,[8] J. Biol. Chem. 287:3104-3115, 2012,[9] Cell Host Microbe. 12: 764-777. 2012.

Virulence mechanism of Helicobacter pylori
vacuolating cytotoxin, VacA

Senior Assistant Professor Akihiro Wada
Assistant professor
Masayuki Nakano
Assistant
Yoshiki Tsutada

Laboratory− 14 −8) E stablishment of a novel malaria model using
ungulate Plasmodium

Department of Protozoology
Malaria is responsible for a huge burden of deathand disease in large areas of the tropical and subtropical world. Unfortunately, those countries hardest
hit by the disease are often amongst the poorest.
Despite continuing efforts, there is still no effective
vaccine against the disease. In order to design andimplement effective disease intervention strategies,
we believe that one of the key priorities in malaria
research should be the strengthening of ourunderstanding of the basic biology of the parasite.
We are currently investigating some fundamental
aspects of the parasite’s life cycle, such as themechanisms behind red blood cell (RBC) invasion
and the phenomenon of cytoadherence of parasiteinfected RBCs using a variety of malaria parasites
including human-infecting Plasmodium falciparum,rodent malaria parasite Plasmodium yoelii, andPlasmodium knowlesi a causative agent of zoonotic
human malaria. To expand a platform for basic andclinical malaria researches, we also aim to establish
novel malaria model systems for Plasmodium vivax
and ungulate malaria parasites. In addition, we arealso conducting research aimed at elucidating theintracellular survival strategy of Trypanosma cruzithat cause Chagas disease and Babesia parasitesthat cause Babesiosis in cattle.

2. Trypanosoma
1) T he function and expression mechanism of transsialidase2) S tage specific adaptation mechanisms employedby different Trypanosoma species
3. Babesia1) Molecular basis of host cell invasion and modification
2) Development of genetic manipulation techniques
for Piroplasm parasites

We are actively pursuing the following lines ofinvestigation:
1. Malaria
1) The molecular basis of host cell invasion by parasites
2) The molecular basis of cytoadherence of parasiteinfected RBCs
3) C alcium signaling in malaria parasites4) Molecular epidemiology of malaria parasites inendemic countries5) Understanding the biology of Plasmodium vivax
hypnozoites6) E stablishment of a reporter line of Plasmodium vivax7) M olecular basis of human Plasmodium knowlesi
infection

Professor
Senior Assistant Professor
Assistant Professor
Assistant Professor
Research Fellow
Research Fellow
Assistant
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Visiting Researcher
Visiting Researcher

Osamu Kaneko
Haruki Uemura
Kazuhide Yahata
Masahito Asada
Amuza Byaruhanga Lucky
Mika Takeda
Reiko Tanaka
Miki Kinoshita
Sachie Takahama
Yuto Kegawa
Kwame Kumi Asare
Ben-Yeddy Abel Chitama
Takahiro Ishizaki
Nattawat Chaiyawong
Hassan Hakimi
Jesse Gitaka Njihia

P. falciparum expressing a calcium biosensor. Fluorescenceresonance energy transfer (FRET) signal from the same
parasite is shown in pseudocolor before (left) and after (right)
adding an inhibitor of calcium-dependent ATPase.

Recombinant protein (green) expressed in P. falciparum colocalized with Maurer’s cleft protein (red) seen in the RBC
cytosol outside of the malaria parasite. Nucleus is visualizedwith blue color.

RBC invasion by P. yoelii. Merozoite-stage parasite (arrowhead)
invades into RBC within 30 seconds (0 - 25 s) and deformed
RBC to spike-like shape (85 s).

− 15 −

Department of Parasitology
Infectious diseases are still a huge menace tohuman health and continue unabated in tropicalareas under the conditions of poverty and the uniquenatural and social environments. Various kinds ofparasites infect humans for long periods of time
without killing them, giving rise to tremendous
afflictions, social and/or economic loss. We would
like to develop deep insight into parasitic diseases
and the surrounding factors from various points ofview through both field and laboratory studies. Our
goal is to contribute to new knowledge and to provide
an enthusiastic environment for the training of the
future generation of investigators.
Target diseases of our studies
We have been carrying out both field and laboratory
studies on several of the most important helminthic
diseases, including schistosomiasis, filariasis andintestinal helminthiasis and on important but neglected
protozoan diseases such as amoebiasis, leishmaniasis
and trypanosomiasis.

Houpt at University of Virginia, we elucidated thepathogenicity of Entamoeba moshkovskii, and now
are devoting ourselves to the study on molecular basisof pathogenicity of and host defense mechanisms to
E. histolytica.
3. Cohort study using HDSS on infectious diseases in
Mbita and Kwale area in Kenya
We are repeating cross-sectional study on infectious
diseases including shistosomiasis, other helminthic andprotozoan infections, Malaria, tuberculosis and so on, in
Mbita area using HDSS (Health and Demographic
Surveillance System) as the collaboration with London
School, Niigata Univ. and Dept. Vector Ecology andEnvironment, Immunogenetics and Eco-epidemiology. In
2017, we have just started a new project to clarify “thedynamics of Schistosoma mansoni transmission and its
environment along with Lake Victoria” with the support
from MEXT Grant-in-Aid for Scientific Research (A).

1. Schistosomiasis, Filariasis and STHs
We have been researching parasitic diseases in
Mbita Kenya, in cooperation with Kenya Medical
Research Institute (KEMRI). In the laboratory, we
maintain Schistosoma mansoni and intermediatesnails and are trying to elucidate immune responses
as well as to develop ideal diagnostic methods throughthe study on the unique molecules belonging to
Schistosoma spp. In 2017, we have just started“DeWorm3” project in Japan which is supported by
the Bill & Melinda Gates Foundation as a collaboration
with the Natural History Museum, London.
We set up lymphatic filariasis and neglected
tropical disease unit (LF-NTD Unit) together with Prof.
Kazuyo Ichimori, so as to contribute to the activities
toward Global Program to Eliminate LF and NTD by
WHO. In the laboratory, Brugia malayi, B. pahangi
and Aedes aegypti are maintained.
2. Amoebiasis, Leishmaniasis, Trypanosomiasis etc.
Cohort studies on leishmaniasis are carried out incooperation with the International Centre for Diarrheal
Disease Research, Bangladesh (ICDDR, B.) and Oita
University. Field sites include Dhaka and rural areas of
Bangladesh. In the laboratory, we study host defense
mechanisms against Leishmania major, L. donovani,
Trypanosoma cruzi, and in the process, have elucidated
the function of the IL-12 cytokine family such as IL27/WSX-1 during infection. We initiated developing
the live attenuated vaccine to leishmaniasis byediting a gene using CRISPR-Cas9 system with thesupport from Global Health Innovative Technology
Fund (GHIT) in 2015. In addition, we developed animalmodels of intestinal amoebiasis together with Prof.
− 16 −

Professor
Visiting Professor
Visiting Professor
Visiting Professor
Assistant Professor
Assistant Professor
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Medical Student
Medical Student
Technologist
Assistant
Assistant
Assistant
Assistant
Assistant

Shinjiro Hamano
Dinesh Mondal
Sammy Njenga
Abhay Satoskar
Yoshinori Mitsui
Risa Nakamura
Shumpei Kambe
Kenichi Nobusue
Taeko Moriyasu
Sharmina Deloer
Evans Asena ChadekaMusa Abu Mohamed
Khanjada Shahnewaj Bin Mannan
Mitsuko Hasegawa
Mukendi Kambala Jean Pierre
Mio Tanaka
Talaam Kiplangat Keith
Gavicho Lindo Celestino
Ishii Jo
Yamasaki Risa
Megumi Hamasaki
Hiromi Oda
Fumie Hara
Yasuko Kawabata
Chiaki Hisata
Hena Asma

Our research activity in a primary school in Kenya

severity2) E arly stage predictors for severe Dengue fever* Free DNA, Chymase, VEGF ATⅢ

Department of Immunogenetics
This department is focusing on the pathogenic
genetic factors of the host and the parasite in themost important tropical infectious diseases by using
immunology and genetics.
Research activities:
To clarify the molecular mechanisms in the protective
and/or pathogenic host response to human pathogens
such as Dengue virus, Malaria, Trypanosoma cruzi andSchistosoma, the following research projects are goingon in our laboratory.
1. Malaria
1) Genetic analysis of malaria endemicity2) Vaccine development* Py Transamidase (TAM) vaccine with nanoparticle
delivery system
2. Schistosomiasis
1) Vaccine and Drug target molecules identification
by genomics and proteiomics* SEA motif bearing gene family
3. Chagas disease1) Genetic susceptibility to different clinical typesof chronia Chagas disease, namely, indeterminate,cardiac, and digestive forms* HLA-B14 haplotype as resistant against chronic
complications2) Host and Parasite factors influencing on thereactivity to the chemotherapy in the paediatricpatients with chronia Chagas Disease. Ongoing3) Compound library screening by using in vitro
culture of T.cruzi* Astellas open innovation network including
U.Tokyo, Tokyo Institute of Technology, AIST
(National Institute of Advanced Industrial
Science and Technology), and DNDi
4. Dengue fever1) Pathogenesis of the DHF(Dengue Hemorrhagic
Fever)* HLA, Mast Cell derived factors, related toMembers

Collaborations:
The research here is performed based on thewell-arranged collaborative projects with the following
facilities.
1. Malaria: Karolinska Institute (Sweden), Kenya Medical
Research Institute (KEMRI). London School of Hygiene
and Tropical Medicine, University of Liverpool
2. Schistosmiasis: Jiangxi Provincial Institute of Parasitic
Diseases (China), Jiangsu Provincial Institute ofParasitic Disease (China), RITM (Philippines).
3. Chagas Disease: Center of Tropical Medicine, Sirani
Clinic, and Hospital Japones (Bolivia), IICS Universityof Asuncion (Paraguay).
4. Dengue Fever: Ho Chi Minh Pasteur in Vietnam,
Pasteur Paris, McMaster University
Professor
Associate Professor

Kenji Hirayama
Nguyen Huy Tien
(Clinical Product Development)
Senior Assistant Professor Mihoko Kikuchi
Assistant Professor
Cherif Mahamoud Sama
Assistant Professor
Shusaku Mizukami(Clinical Product Development)
Assistant Professor
Dumre Shyam Prakash
Research Fellow
Chisato Narahara
Assistant
Michiko Fukuda
Assistant
Yoko Hosoi
Graduate Student
Vasquez Velasquez Clara Alejandra
Graduate Student
Dao Huy Manh
Graduate Student
Farhana MosaddequeGraduate Student
Mathenge Peterson Gitonga
Graduate Student
Maiko Akashi
Graduate Student
Kota Mochizuki
Graduate Student
Miho Inokuchi
Graduate Student
Teklemichael Awet Alem
Graduate Student
Pembi Emmanuel
Graduate Student
Nguyen Thi Ngoc Phuong
Graduate Student
Yuki Tayama
Visiting Researcher
Yukimi Katagami

Experiment scenery− 17 −

Fieldwork in Bolivia

Department of Pathology○Division of Malaria○Division of Pathology
Main purpose of our research is fundamentally
pathological investigation of tropical diseases, mainly
infectious diseases, focused on oncogenic microbes,
and establishes the basis of their treatment andprevention. Although many investigators have proposed
oncogenesis due to inflammation associated cancer
development, the mechanisms underlying therelationship between chronic inflammation andcancer still remain unresolved. Therefore, ourresearch focuses on the potential role of oncogenic
microbes in the development of cancers, highlighting
the recent advances in the understanding of themolecular mechanisms.
The proportion of total cancer deaths attributable
to infectious agents is estimated to be 20% to 25% indeveloping countries and 7% to 10% in industrializedcountries. A causal relationship between chronic
inflammation and cancer is widely accepted.
Specifically, there is a strong association between
tumor viruses and the development of humancancers. The mechanisms of oncogenesis associatedwith infection and inflammation have not been
elucidated. However, many oncogenic mechanisms
have been proposed for infection and inflammation.
Activation of NF-κB is also involved cancer development
and progression. Therefore, our research focuses on
the molecular players during the development fromchronic inflammation to cancer.

We are a small, highly driven malariology groupfocusing on many different aspects of malaria.
Established in 2011, we believe in a multi-disciplinary
approach to studying malaria, as this enables abroad understanding of the subject, and therefore
facilitates the development of novel solutions forfighting the disease. Such a holistic approach todisease research can succeed only on the foundationof a solid and detailed understanding of its multidisciplinary constituents.
Our core belief is that all our research should
produce results that are of potential practical use forfighting the disease. We also strive to engage young
researchers in studies on malaria, and hope toencourage them to develop enthusiasm for usefulscientific research. Research should be fun, and wetry to foster a freethinking and engaging research
environment for students working with us.
We are interested in all aspects of malariology,
and are currently actively engaged in research
projects involving immunology, genetics, genomics,
evolutionary theory, ecology, epidemiology, andmolecular cell biology.
One particular ongoing project involves analysisof asymptomatic malaria carriage in Nigeria.
Collaborative projects with malaria researchers
based in Japan and internationally are of enormous
importance to us, and make up the bulk of the work
we are currently engaged in. At present we are
actively working with researchers from the USA, theRepublic of Congo, Vietnam, Sri Lanka, Australia,
Tanzania, Kenya, Nigeria, Brazil, the UK and Saudi
Arabia.
Associate Professor
Assistant Professor
Assistant
Graduate student
Graduate student− 18 −

Richard Culleton Leighton
Masachika Senba
Sarina Hokama
Ernest Medard
Ifeoma Ugwuanyi

Department of Eco-epidemiology
Our department is involved in various branchesof public health research. Through cutting edge IT
and biotechnology, we aim to create more accurate
assessment methods in global health, improve
responses to public health needs on a local scale, andopen new directions in health science to pass on to
future generations. Our activities include the following:1) Development of microsphere-based simultaneous
multiple assays and surveillance systems for multiple
infectious diseases in Africa. Neglected tropicaldiseases (NTDs) are spreading across Sub-SaharanAfrica, but the actual situation of NTDs is still unclear.
Simple and cost effective methods for monitoring
NTDs are desirable, especially where distributions ofmultiple NTDs are overlapping. Toward this goal, we
are developing a simultaneous multiple antibody
assay system, utilizing microsphere-based multiplex
technology.
2) Health and Demographic Surveillance System(HDSS) in Lao PDR. In many developing countries, civil
registration and vital statistics systems are still deficient.
Health and Demographic Surveillance System (HDSS)
is a resident registration system for epidemiologicalresearch in a given locale. HDSS follows residents andtheir dynamics over a long-term period. In Lao PDR, we
are operating two HDSSs to design research andimprove health conditions in rural communities.

5) Finding malaria vaccine candidate antigens using
microsphere-based simultaneous multiple assays.
We are working to find novel candidate antigens formalaria vaccine using a cohort in a malaria endemic
area with a microsphere-based multiplex assay system.
6) Researches clarifying the molecular bases of parasitic
diseases. Besides field works, basic researches especiallyon schistosomiasis, amoebiasis and leishmaniasis
are being conducted in our lab. We are aiming bringing
back the results to field works.
7) A scientific approach to community-led total
sanitation strategies in Africa. The aim of this study is
to develop Community-Led Total Sanitation (CLTS)
models in Africa. We particularly focus on improving
community health through the promotion of toilet use.
8) Support for JICA project in Sri Lanka and Serbia.
With increasing economic development and longer
life expectancy, the number of lifestyle-relateddiseases or non-communicable diseases (NCDs) is
expected to increase. However, a mechanism to grasp
the actual situation of NCDs does not currently exist in
Sri Lanka. The department has cooperated with the
JICA NCD management project to establish a systemfor estimating the number of patients with NCDs.
In Serbia, enhancement of breast cancer screening
program is operated by JICA. From epidemiologicalpoint of view, the department is supporting the JICA
project in Serbia.

3) Epidemiological studies for child health in Kenya.
Kwale district is categorized as one of the poorest
areas in Kenya. The infant mortality rate in the region
remains high. Poor nutritional status in Kwale children
contributes to a high prevalence of stunted growth.
To improve this situation, we are conducting a childcohort study, attempting to reveal factors that could
prevent stunted growth.
4) Research on dengue prevention through a residential
environmental clean-up program in Sri Lanka. Dengue
fever is one of the major health problems in Sri Lanka,
and measures of prevention are urgently needed. We are
evaluating the effects of environmental intervention: e.g.,clean-up activities such as collection of containers left
outdoors that act as breeding sites for dengue mosquitoes− 19 −

Professor
Associate Professor
Assistant Professor
Visiting Professor
Visiting Researcher
Research Fellow
Research Fellow
Research Fellow
Research Fellow
Visiting Researcher
Visiting Researcher (JSPS)
Visiting Researcher
Assistant
Assistant
Assistant
Assistant
Graduate Student
Graduate Student

Satoshi Kaneko
Yoshito Fujii
Kentaro Kato
Naoyuki Kawahara
Tomoko Komagata
Yombo Dan Justin Kalenda
Rie Ozaki
Tomonori Hoshi
Daniel Toshio Harrell
Kazuya Ogawa
Job Wasonga
Chisa Shinsugi
Emi Nakayama
Kuniko Shimoda
Shiho Chikatoshi
Mitsumasa Miura
Junichi Tanaka
Mami UchidaDepartment ofInternational Health
Department of International Health has started
its activities since 2008, following the internal reformof Institute of Tropical Medicine. Department ofInternational Health has its basis on Research Center
for Tropical Infectious Diseases (RECTID) of Instituteof Tropical Medicine established in 2001, Information
and Reference Center in 1997, and Reference Centerin 1994.
It says that RECTID, a precursor of our department,
had following three activities; 1) developing the museumof tropical medicine, 2) collecting and disseminating
information on tropical infectious diseases and 3)
promoting joint research projects and doing
epidemiological studies. Out of which, Department ofInternational Health takes over research activities
and adds to its mandate an international collaboration
as a social responsibility anew. Thus, Department ofInternational Health, as a newly established department,
has two pillars, e.g. research and social responsibility.
Research was composed of three units; 1) researchon infectious diseases in ecosystem, 2) research on
the environment including climate change and Asian
dust related to health, 3) research on biologicalevolution of microorganisms from the adaptation or
fitness viewpoint and 4) research on the epidemiology
from the historical viewpoint. The umbrella concept
or key word linking above four research units is toreconstruct infectious diseases “temporally” and“spatially” alike. Infection is the biological interaction
between hosts and microorganisms. In other words,
host behavior, social structure as well as culture per
se affect microorganisms in fitness and adaptation
whereas microorganism has impact on its hosts.
Based on that perception, our department aims to
get more detailed understanding and insight on
infectious diseases. For examples, we would like topursue the ways of analysis by various approaches
such as molecular-evolutional technique, molecularepidemiology, detection of trace DNA, genomics basedon bioinformatics, mathematical model, and computerscience. In addition to these researches of infectious
diseases, we decided to add the historical approachbased on documentary records in order to understandwidely the relationship between creatures and societies.
Another pillar is a social responsibility. Now thateven profit oriented organizations are required tohave its corporate social responsibility, no need tosay for academia or university. Out of the name of ourdepartment, it must be nothing but contribution tointernational health or people’s health in resourcelimited settings.
Our department raises following three activities asinternational contribution; advocacy on international
health at national and international level, health promotion
activities and empowerment at the community/
grassroots’ level and emergency relief.
What our department thinks of important in those
activities is to make solidarity in order to improve
people’s health and contribute to people’s sustainable
development. It is our department’s goal.

− 20 −

Professor
Associate Professor
Assistant Professor
Assistant Professor
Visiting Professor
Visiting Professor
Visiting Professor
Visiting Professor
Visiting Researcher
Visiting Researcher
Visiting Researcher
Visiting Researcher
Visiting Researcher
Visiting Researcher
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Taro Yamamoto
Takayuki Wada
Tomoo Ichikawa
Masayuki Nakano
Shigeru Suganami
Kui-Chen Zheng
Ishii Masami
Akihiro Seita
Hiromu Ito
Taijin Kaku
Liang Qin
Guoxi Cai
Syuko Takahashi
Katsura Igai
Kayo Maeda
Yoshihiro Takayama
Shiomi Yoshida
Kaori Yamamoto
Hiroyuki Arima
Raoping Tu
EZZAN SAEED MOHAMMED KUNNASWETA KOIRALAAKINTIJE SHIMBA CALLIOPE

Department of Vector
Ecology & Environment
Our research interests include anything from
ecology to molecular biology of medically important
arthropods, particularly mosquitoes that transmit
diseases such as malaria and dengue. We are alsointerested in their relationships with environmental
variables and development of environmentally friendly
vector control tools.

also investigating the effects of bed nets on thespecies composition of vectors and their behavior,and monitoring their insecticide resistance in East
Africa.

1. Dengue vectors
As dengue vectors are extending their geographic
distribution, the spread of the disease is being
concerned. It has been suspected that the expansionof vector distribution is due to environmental factors
such as climate change. We are currently mapping
their geographical distributions in South East Asia
and Africa, and examining the relationships withenvironmental factors.
2. Malaria vectors
We are examining ecological and physiologicaldifferences among the members within the Anopheles
gambiae complex group and the Anopheles funestus
group in Kenya and Malawi. We are also investigating
their geographic distributions, and monitoring theirabundance in East Africa. This extensive field survey
was designed to understand the effects of climate
and develop a climate base malaria prediction
model.
3. Vector control measures
The coverage of insecticide treated bed nets
(ITNs) has considerably increased in Africa. We areinvestigating whether local residents properly use
and maintain ITNs, and how long ITNs last. We are− 21 −

Professor
Associate Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Noboru Minakawa
Hitoshi Kawada
Toshihiko Sunahara
Yukiko Higa
Takashi Tsunoda
Kyoko Futami
Ataru Tsuzuki
Hu Jinping
Chiaki Tsurukawa
Naomi Sano
Junko Sakemoto
Koji Yamada
Huynh Thi Thuy Trang
Nozomi Imanishi
Sai Zaw Min Oo
Yang Chao
Nayu Sukehiro
Yasue MorimotoDepartment ofClinical Medicine
This is the only clinical department in NEKKEN,
which does clinical practices in Nagasaki University
Hospital. We conduct a wide range of multi-disciplinary
studies bridging our strength of clinical epidemiology
to laboratory-based microbiology and immunology
studies both in- and outside Japan. Our main researchinterests are respiratory infectious diseases, tropicalinfectious diseases, tuberculosis (TB) and HIV/AIDS.
Specific research topics are as described below:

4. HIV/AIDS Studies
In collaboration with National Institute of Health,Thailand, Bac Mai Hospital, Vietnam, Philippine General
Hospital, and Nagoya Medical Center, we haveinvestigated the pattern of opportunistic infections
among HIV/AIDS patients and disclosed different
clinical pictures in different geographical settings.
Professor
Associate Professor
Assistant Professor
Assistant Professor
Assistant professor
Senior Lecturer
Assistant professor
Assistant professor
Assistant professor
Assistant professor
Visiting Professor
Visiting Professor
Visiting lecturer
Visiting Researcher
Visiting Researcher
Visiting Researcher
Assistant Researcher
Assistant
Assistant
Assistant
Assistant
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student

1. Respiratory Infections Diseases
We apply our in-house multiplex-PCR assays toidentify 19 different viral and bacterial respiratory
pathogens and a novel nano-fluidic real time PCRbased assay to determine 50 pneumococcus serotypes
for a multi-center adult pneumonia survey all overJapan and childhood acute respiratory infection
study in central Vietnam. We published several papers
demonstrating vaccine efficacy against pneumococcal
pneumonia and influenza. Since 2009, we have run abirth cohort studies of about 2,000 pairs of mothers
and new-born babies, which facilitates studies of hostgene factors associating the severity of pediatricinfectious diseases. We also investigate the pathogenesisof treatment-refractory pneumonia at molecular levels
focusing on macrophage function, of clearing apoptotic
cells from the inflammation site.
2. Tuberculosis
For better-diagnosis of latent MTB infection andtuberculosis, we are analyzing cellular immune responses
to various TB antigens using an intra-cellular cytokine
staining assay to evaluate a range of cytokines profile
in various stages of TB infection and their contact
cases both in Japan and abroad. Our goal is to clarify
TB-specific cellular immune responses characteristic
to a different clinical stage of TB infection. We also
investigated pathogens causing bacterial pneumonia
and its impact on the survival prognosis of TB patients
admitted to the National Infectious Diseases Hospital(San Lazaro Hospital) in the Philippines.
3. Fever management in the tropics
In collaboration with National Institute of Infectious
Diseases, Tokyo, we are conducting undiagnosed
febrile illness study in the Department of Infectious
Diseases, Bac Mai Hospital, Hanoi, Vietnam and the
National Infectious Disease Hospital (San Lazaro
Hospital), the Philippines, by applying diagnostic tests
for leptospirosis and various richettial diseases. We
also coordinate a bed-side clinical training course on
tropical infectious.

Koya Ariyoshi
Konosuke Morimoto
Motoi Suzuki
Hikaru Sato
Yoshiro Yamashita
Takeshi Tanaka
Masahiro Takaki
Emi Kitasyoji
Hirotomo Yamanashi
Kensuke Takahashi
Michio Yasunami
Christopher Parry
Akitsugu Furumoto
Masahiko Mori
Bhim Gopal Dhubadel
Mai Izumida
Taisuke Nakamura
Rina Shiramizu
Kyoko Uchibori
Yumi Araki
Seiko Kudo
Tohru Ogasawara
Reiko Miyahara
Nobuo Saito
Satoshi Kakiuchi
Ngo Chi Cuong
Hiroshi Fujii
Shungo Kato
Hiroyuki Ito
Kentaro Hayashi
Eiichiro Sando
Tomoko Hiraoka
Ikkou Yasuda

Bed-side clinical training course in San Lazaro Hospital− 22 −

Department of Pediatric
Infectious Diseases
The Department of Pediatric Infectious Diseases
conducts research on a wide range of infectious
diseases with special attention on severe pediatricinfectious diseases including pneumonia, diarrhea,
dengue and malaria. Our research interests include
integration of clinical, environmental and social
issues at global, national and local levels.
Cohort studies on Pediatric Infectious Diseases in Vietnam
We receive funding from the Japan Initiative for
Global Research Network on Infectious Diseases(JGRID), Japan Agency for Medical Research andDevelopment (AMED) to conduct a large population
based cohort study on Pediatric Infectious Diseases
in Nha Trang, central Vietnam since 2006. We arefocusing on severe common pediatric infectious
diseases (SPID) such as acute respiratory infection(ARI), diarrhea and dengue which are the major
causes of under 5 mortality.
Pediatric ARI surveillance: A population based
hospitalized Pediatric ARI surveillance at Khanh Hoa
General Hospital, Nha-Trang, Vietnam was establishedto determine incidence, etiology and risk factors forpediatric ARI/pneumonia since 2007. We also investigate
the emergence of new viruses and its molecular andclinical importance. In addition, we also investigate
the impact or potential of various vaccine introduction
on pneumonia and dengue in a population level.
Birth cohort study: We are also conducting abirth cohort study on 2000 new born babies in Nha
Trang, Vietnam since 2009. This study was conductedto study congenital infection and host genetic factors
on physical-neurological development of the child anddevelopment of SPID. We are also studying congenital
rubella infection and its complication in Vietnam.
Pneumococcal conjugate vaccine (PCV) reduced
dosing trial: We received a multimillion dollar grantfrom Bill and Melinda Gates Foundation to conduct a
PCV reduce dosing trial in Vietnam. We believe thatthe study outcome will change global PCV vaccination
strategy to improve the availability of PCV and othervaccines in developing countries.
Health impacts of global environmental change
Our research interests extend over a range ofissues in environmental epidemiology. The current
research topics, which we work in collaboration withboth the international and Japanese colleagues, focus
on the health impacts of atmospheric environmental
changes including global climate change andtransboundary and local air pollution. Ongoing projects
include:1. E
 ffects of flooding and weather on diarrhoea, acuterespiratory infections and other infectious diseases.
2. Ocean-atmosphere interaction phenomena including
the Indian Ocean Dipole and its association with malaria
and cholera in the Eastern and Southern Africa.
3. Health effects of local and transboundary air pollution
in Japan and in the East and Southeast Asia.
4. Mortality risk of temperature extremes in tropicalclimate where we estimate excess mortality associatedwith exposure to temperature extremes and theextended period of heat in tropical countries.
5. Respiratory health effects of the different chemicalcomposition of airborne particulate matter and thesources.
6. Heat effect on mortality in Japan
7. Associations between weather factors and suicide
in multiple countries in Asia, Europe, and America
8. Development of malaria early warning system inSouthern Africa
Professor
Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant
Assistant
Assistant
Assistant
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student

Masahiro Hashizume
Lay Myint Yoshida
Ng Chris Fook Sheng
Kim Yoonhee
Michiko Toizumi
Noriko Kitamura
Mizuki Takegata
Chihiro Iwasaki
Le Minh Nhat
Nozomi Oka
Setsuko Hirakura
Kaori Yoshida
Kayoko Kamihiro
Keisuke Yoshihara
Eriko Ikeda
Naohiko Matsusita
Saki Tanaka
Atsushi Fujioka

Environmental change and global
health research in Bangladesh

Nha Trang PCV study vaccination
field work.

− 23 −

Cholangiocarcinoma and Malaria.
3) Physiological Based Pharmacokinetics (PBPK)
Modelling in Malaria and Cholangiocarcinoma
4) Development of Novel Treatment for Dengue
patients
5) P erformance of researches on evidence-based
medicine, evidence synthesis, secondary data
analysis, and health care survey to improvehealth care6) Development of Teaching Methodology to Enhance
Medical Student conducting research7) Identification and addressing Methodological andEthical Issues in Biomedical Science8) Identification of Ethical Issues in Research
Publications

Department of Clinical
Product Development
This is a newly established department in responseto the Global Strategy on public health, innovationand intellectual property (resolution WHA61.21). The
resolution calls for the enhancement of health-needs
driven research and development to address diseases
that disproportionately affect developing countries.
The establishment of this department was supportedby the Department of Academic and Research Promotion,
Ministry of Education, Culture, Sports, Science andTechnology (MEXT), Japan. MEXT continues to support
the department until its full development.
The department focuses on:
1. B uilding capacity of individuals for innovation in
health product2. S trengthening capability of the local research
institutions in providing an enabling environment,
including infrastructure for product R&D
3. S trengthening research institutes network forknowledge sharing and exchange, and for R&D
technology transfer activities. The emphasis will be
on developing products for public health needs toaddress the issues of inequity in health.
4. F
 illing the gap of health knowledge
The operation of this department depends on thecollaboration of existing offices and departments in
NEKKEN and in Nagasaki University, e.g. Office forTraining and Education, Immunogenetics, Toxicology,
Clinical Pharmacy, Parasitology, Clinical Medicine,
Clinical Pediatrics, Center for infectious disease researchin Asia and Africa and the research institutions anduniversities in developing countries. The aim of its
operation is to ensure that research priorities of research
institutions are in line with their public-health needs, inparticular the need for innovative research to address
the health problems of their populations and tocontribute to improved public health in other countries.
The activities:
1. Training
1) Two- week course on Product Research andDevelopment for public health needs;
2) Three-day course on Bioethics
3) Three-day course on Conducting Responsible
Research4) PhD training as part of actual product development
ie. Shiunko for Cutaneous Leishmaniasis, Herbal
Medicine for Cholangiocarcinoma and Malaria
5) PhD training as part of associated productdevelopment processes e.g. ethical issues in
product development, clinical data management,
good laboratory practice and etc.
6) Online learning courses for undergraduate
students and young medical doctors to conduct
evidence-based medicine, evidence synthesis,
secondary data analysis, and health care survey

3. Network
1) Coordination of Product Research and Development(PRD) Network2) C oordination of research ethics global network:
Strategic Initiative for Developing Capacity in
Ethical Review (SIDCER)
3) S upervisor of Online Research Club: Mentoring
global young clinicians and medical students to
conduct several types of research
Collaborations:
1. Drug Research Center, Thammasat University,
Bangkok, Thailand
2. Forum for Ethical Review Committees in the Asianand Western Pacific Region (FERCAP), Bangkok,
Thailand3. Armauer Hansen Research Institute, Ministry of
Health, Addis Ababa, Ethiopia
4. Institution of Human Research Protection, Ministryof Health, Thailand
5. Liverpool School of Tropical Medicine, Liverpool,
England
6. National Research council of Thailand, Thailand
7. Institute of Herbal Medicine, University of Philippines,
Manila, Philippines
8. University of Medicine and Pharmacy at Ho Chi
Minh City, Ho Chi Minh, Vietnam
9. Ton Duc Thang University, Ho Chi Minh, Vietnam
10. Pasteur Institute of Ho Chi Minh City, Vietnam
11. Kumamoto University Graduate School of Medical
Sciences, Kumamoto, Japan12. Institute of Natural Medicine, University of Toyama,
Toyama, Japan
MemberProfessor
Associate Professor
Assistant Professor
Visiting Professor
Visiting Researcher
Assistant
Graduate Student
Graduate Student

2. Research
1) Development of Shiunko for Cutaneous Leishmaniasis;2) Identification and further development of Herbal
Medicine and novel small compounds for− 24 −

Juntra Laothavorn
Nguyen Tien Huy
Shusaku Mizukami
Kesara Na-Bangchang
Tullayakorn Plengsuriyakarn
Sayuri Delaney
Nut Koonrungsesomboon
Teerachat Sae-heng

Center for Infectious Disease
Research in Asia and Africa○Kenya Research Station

OutlineNagasaki University Kenya Research Station isan overseas research site that was established throughthe “Program to Establish Infectious Disease Research
Network” (Sept. 2005- Mar. 2010) and“Tropical Medicine,
Emerging Infectious Disease and Clinical EpidemiologicalResearch Program” (Apr. 2010-Mar. 2016) funded by the
Ministry of Education (MEXT) in Japan. Since April 2016,
the site received renewed funding from MEXT titled,“Program for Research and Capacity Development
Toward Infectious Diseases Control” to establish an
education and research collaboration platform for Kenya
and Japan.
The goals of this project are to strengthen the
Kenya Research station, to train young researchers
on emerging and re-emerging infectious diseases,
and to collaborate with local researchers on longterm projects.
Progress
1. Establishment of The Research Station
We have made progress on establishing the
Kenya Research Station in Nairobi (including the
Biosafety Level 3 laboratory) and field research sites
in Mbita, Kwale and Busia. Renovation of the building
and conference rooms, maintenance of information
systems, and procurement of vehicles are currently
ongoing.
2. Researchers and administrative staff from Japan
Two researchers including the Chief Representative
and three administrative staff members were dispatchedfrom Japan to Kenya. Four Professors and Two Associate
Professors and two Assistant Professors have supported
our project through short-term visits.
3. Contribution to the Community members
In Mbita and Kwale areas, Health and Demographic
Surveillance System (HDSS) has collected data on
population, birth and death rates, and incidences of
diseases over time. Mosquito Surveillance System(MSS) collects and analyzes data on malaria mosquitos
in Mbita. In 2012, we began a new project through the
JICA Partnership Program focusing on school healthin Mbita which has been ongoing since 2009.
4. Tropical Medicine Research
Research on parasitology, malaria eradication,and mosquito transmission research are ongoing in

Our Members

Western Kenya, Research on bacterial and viraldiarrheal disease and mosquito-borne hemorrhagic
fever are continuing in the laboratories at the P3 lab
in Nairobi Office and at the Kenya Medical ResearchInstitute, Production Department.
In Kwale, epidemiological research of maternal
child health are being conducted. “The JICA-AMED
Satreps Project for Development of Rapid Diagnostics
and the Establishment of an Alert System for Outbreaksof Yellow Fever and Rift Valley Fever in Kenya” started
in March 2012 has completed in January 2017. The
mSOS system (mobile SMS-based disease outbreakalert system) was established at the Ministry of Health.
A lab. for seroepidemiology project focusing on NTD(neglected tropical diseases) was set up with fundingby the Japan Science and Technology Agency (JST)(1st phase: 2009-2011, 2nd phase:2011-2016). The 3rdphase started in Nov. 2015.
5. Educational Programs
Five medical doctors from Kenya graduated from“the Master of Tropical Medicine at the Institute ofTropical Medicine in Nagasaki”. Five Kenyan students
are currently enrolled in graduate school of the“Program for Nurturing Global Leaders in Tropical andEmerging Communicable Diseases” at the Institute ofTropical Medicine. Every year, we give opportunities
for three master students from “The Nagasaki
University School of Tropical Medicine and Global
Health” to study in Kenya. We also have accepted
medical school students from Osaka University, Osaka
City University and Shiga University of Medical
Science and so on for field trainings.
Project Members
Chief Representative, Professor Yoshio Ichinose (Kenya)
Professor
Noboru Minakawa
Shinjiro Hamano
Masahiro Hashizume
Satoshi Kaneko
Associate Professor Shingo Inoue
Yoshito Fujii
Daisuke Hayasaka
Assistant Professor
Kyoko Futami
Mohammad Shah
Rie Takeuchi(Kenya)
Administrator
Haruki Kazama (Kenya)
Administrative/HR Manager Yukie Saito (Kenya)
Chief Accountant
Shizuko Yagi (Kenya)
Administrator
Kaori Mori
Graduate Student
Shunpei Kambe
Graduate Student
Gabriel Dida

NUITM Kenya Research Station(Nairobi Office)− 25 −

Mbita Research Site

Kwale Research Site

Center for Infectious Disease
Research in Asia and Africa○Vietnam Research Station

OutlineThe Institute of Tropical Medicine (ITM), Nagasaki
University and the National Institute of Hygiene andEpidemiology, Vietnam (NIHE), have been jointly
conducting a collaborative project since 2005 on
emerging and reemerging infectious diseases undera grant from the Ministry of Education, Science, Culture
and Technology (MEXT) of Japan. A Vietnam researchstation established on the NIHE campus has been thesite of number of research activities. The project forclarifying environmental and social factors affecting
outbreaks of zoonosis, vector-borne infectious diseases,
diarrhoea, and childhood pneumonia has been
conducted within a collaborative project framework.
Having achieved the goals set or research in the project’s
first phase (from 2005 to 2009), the next objectives had
been underlined, clarifying the factors and mechanisms
causing infectious diseases (from 2010 to 2014).
Since 2015, the project has been taken over tothe third phase under a grant from the newly establishedJapan Agency for Medical Research and Development(AMED). Four main subjects i.e., Dengue fever, Infectious
diarrhoea, Influenza, and Drug resistant bacteria wereselected for taking the aim of development an interventionbased method to inhibit the spread of infectious diseases.
In Vietnam Research Station, we have conducted over
20 independent activities including collaborative researchwith other Japanese institute. To conduct projects on ahigher level, cooperation has been established with three
Vietnamese governmental research institutions and with
JICA-supported national hospitals. The outcome of suchactivities is expected to contribute greatly to promoting
public health and improving medical care.
Research activities (The activities which have been
implemented in the J-GRID program were described)
The objectives of the entire project are (1) to clarify
the ecology of pathogens in nature and in human society,(2) to clarify the pathogenic mechanism of humandiseases. The principal research agenda are as follows:

1. Dengue fever research:
1) C omprehensive analysis of dengue viruses for
identification of pathological factors and applicationin new drug development.
2) A study of mosquito vectors, pathogenic mechanismof dengue fever, and anti-infection measures3) Vector capacity of mosquitoes to transmit arbovirus4) S earching for the potential seeds for prevention
2. Dengue fever research (consortium):1) Inter-regional analysis of dengue viruses.
2) G lobal movement of variation of dengue vector
mosquito: Building a database for countermeasure.
3. Infectious diarrhoea research1) A study on the effects rotavirus vaccine will makeon the reduction of diarrhoeal disease burden andthe dynamics of circulating strains2) H ospital based and a community based studies
of a broad range of etiological agents of diarrhoea
in Vietnam
3) A molecular epidemiological study of Vibrio
cholerae in ecosystem in Vietnam
4. Infectious diarrheal research (consortium)1) Inter-regional studies of a broad range of
etiological agents of diarrhea in Southeast Asia
5. Pediatric acute respiratory infection research:
1) A birth cohort based study for acute respiratory
infection2) A birth cohort based study for influenza
3) A birth cohort based study for drug resistantPneumococcus
Vietnam Research Station (VRS) staff
Professor
Futoshi Hasebe
Assistant Professor
Takashi Tsunoda
Assistant Professor
Taichiro Takemura
Administrative Staff
Kei Saito
Research Assistant
Phan Hoai Linh Ly
Research Assistant
Doan Thi Hang
Research Assistant
Le Thi Kim Anh
Research AssistantNguyen Thi Hang
Research AssistantPham Hong Quynh Anh
Research AssistantNguyen Thu Trang
Research AssistantPham Ha Chau
Research Assistant
Vi Thi Quynh Trang
Secretary
Bui Thu Tra
Assistant
Mayumi Nakano− 26 −

Tropical Medicine Museum
Museum of Tropical Medicine was preceded by
the Tropical Medicine Reference Centre, which wasestablished in 1974 and was reorganized in 1997 as
Tropical Medicine Reference and Information Center.
In 2001, it was renamed as Research Center Tropical
Infectious Diseases (RECTID) and in 2008 it wasestablished as an auxiliary institution. In addition, thepresent museum was moved to Nagasaki University
Museum of Medicine. The display was renewed.
The institution performs the following 2 functions.
The institute primarily functions as a museum
and resource center for tropical disease. There is a
general section providing information on tropicaldiseases, parasites bacteria viruses poisonous
insects and specimen of dangerous animals, valuablebooks, and displays images of the data. Moreover, it
has an audio-visual room accommodating a few
numbers of people. Furthermore, a system is being
developed for using this collection of resources tostrengthen public science and risk communication
with thousand points relating to the history andphilosophy of tropical medicines and infection
symptoms. From April, 2015 through May, Nagasaki
University held “the Nagasaki University exhibition
which fought against an infectious disease” inNagasaki Museum History and Culture. We provided
much exhibits about the tropical disease, andcitizen’s people saw it.
It also functions as an information center for the
dispatch, collection, organization, and analysis of
information on tropical medicine. This has become
an essential component of the daily research activities
related to tropical medicine. Due to infrastructure
rearrangement in 2012, network tools were updatedwith technological innovation and long lasting safety;
thus responding to every need of the users. We also
serviced various databases, using a researchevaluation system and a database of the tropical
medicine museum. Moreover, we provide a similar
environment to research universities overseas with
VPN by including video conferencing system topromote international conferences and e-learningplans.

Tropical Medicine Museum

Head and Professor Noboru Minakawa
Professor		Junko Okumura
Technologist		Kazuo Araki
Assistant		Kiyomi Suda
Assistant		Sayaka Taniyama
Assistant
Satomi Tominaga

The database server

Tropical Medicine Museum− 27 −

Central Laboratory
The aim of Central Laboratory is to operate andefficiently manage common equipments and tosupport general laboratory activities in the institute.
In addition, this laboratory also supports research
activities conducted in the institute by extramuralinvestigators.
Practical exercise in the PhD programusing Super Resolution Microscope○Molecular & Cellular Biology Unit
Molecular & Cellular Biology Unit is responsible
to maintain and operate following equipments locatedin Central Laboratory; 16- and 48-capillary sequencers,
GS junior genome sequencer and mass spectrometrybased genotyping system for genome analysis;
flowcytometer for cell function analysis; fluorescenceluminescence imager for visualization analysis; andLuminex bead-array system and fluorescenceluminescence multilabel counter for multipurpose
analysis. In addition, this unit is also responsible tomaintain equipments/facilities to support generallaboratory activities; such as pure water supply,
ultracentrifuge, lyophilizer, Speed-Vac, French press,
Bioruptor, sample storage in liquid nitrogen,autoclave, dark room and cold room.

○Electron Microscope Unit

Electron Microscope Unit suppports ultrastructuralcharacterization of microbial pathogens and thestructural change of the pathogen-infected cells. This
unit offers high quality imaging services by state-of-art
techniques such as conventional and immuno-electron
microscopy and 3D tomography, and also provide
training on sample preparation and equipment usage.
This unit is responsible for transmission and scanningelectron microscopes (JEOL), high-pressure freezer(LEICA), ultra-microtomes (LEICA and REICHERT),
vacuum coater, hydrophilic treatment device, andosmium plasma coater in addition to general laboratory
facilities for a wide range application of electron
microscopy.

Researchers using 16-capillary sequencer○Light Microscope Unit

Light Microscope Unit provides optical instruments
to perform basic, translational, and clinical researchon the imaging features of infectious disease. We
operate Nikon Infectious Disease Imaging Core
laboratory established in April 2015. The laboratory
has equipped laser scanning confocal/fluorescencemicroscope (NIKON), Imaging flowcytometer (MERCK),
laser scanning confocal/superresolution microscope(ZEISS), and a Virtual Slide Scanner (Nanozoomer
2.0-RS, Hamamatsu Photonics).

− 28 −

Transmission electron microscope
Head and Professor
Senior Assistant Professor
Assistant Professor
Assistant

Shinjiro Hamano
Mihoko Kikuchi
Miako Sakaguchi
Masae Masumoto

NEKKEN Bio-Resource Center(NBRC)The Government of Japan has been making efforts
under its second and third Science and Technology
Basic Plans to create a world-class intellectual platform.
In FY2002 the Ministry of Education, Culture, Sports,
Science and Technology (MEXT) implemented the
National Bio-Resource Project (NBRP) to construct theframework for systematic collection, preservation, anddistribution of bio-resources with a focus on those that
required strategic development by the National
Government. To promote life sciences it is importantthat researchers share the various bio-resources
necessary for pursuing research and development.
The resources produced in years with painstaking
labor will make foundation for future researches. The
NBRP deals with the bio-resources, which will not beable to be restored again if once they are lost.
Through the revision every five years, the NBRP has
been operated under the control of Japan Agency for
Medical Research and Development (AMED) since
FY2015, and the 4th phase of the NBRP started in
FY2017.
Since 2002 Institute of Tropical Medicine (NEKKEN),
Nagasaki University has been taking of Division ofProtozoa in Pathogenic Microorganisms of a Core
Facility Upgrading Program under Medical Mycology
Research Center, Chiba University. NEKKEN BioResource Center (NBRC) contributes the services toresearchers, (1) information of owners and strains ofpathogenic protozoans in Japan on database Website,(2) supply of protozoans from NBRC, (3) acceptanceof protozoan deposit to NBRC and the preservation,(4) supply of protozoan specimens for laboratory
practice of medical-educational schools, (5) examination
for protozoan infections from any medical facilities.

(6) instructions for protozoan detection and for theculture. Pathogenic protozoan resources, which canbe supplied by NBRC, are listed in the figure.
We would like to ask the access to our ProjectWebsite. Your cooperation and support for the project
would be highly appreciated.

− 29 −

http://www.tm.nagasaki-u.ac.jp/nbrc/
E-mail:protozoa@tm.nagasaki-u.ac.jp
Project Representative
Service Manager
Advice Collaborator
Advice Collaborator
Advice Collaborator

Osamu Kaneko
Makoto Kazama
Shinjiro Hamano
Richard Culleton
Kiyoshi Kita

NTD Innovaton Center
Why?
The widening gap between the poor and thewealthy has led to increasing crime rates, disturbancesof public peace, corruption, and a rise in extremism.
Disintegration of health and sanitation in thepoorer regions is of great concern for global health.
The reach of endemic diseases including parasitic
diseases has been expanding, not only withinregions, but also into wider area as shown by the
recent outbreak of Ebola hemorrhagic fever in West
Africa. These health issues need to be dealt with on a
global rather than local level.
To be more specific, a global support framework
is needed to implement measures to mitigate against
the spread and occurrence of chronic infectious
diseases including parasitic diseases that affect thepoor, in developing and tropical regions; regions that
account for 80% of the world’s population. One
continual challenge is in motivating pharmaceuticalcompanies to develop drugs for these less profitable
markets. That is the reason why we call thosediseases as neglected tropical diseases (NTDs).
Japan has been a leader among the G7 countries insupporting major NTDs programs such as the“Hashimoto Parasite Control Initiative” and the“Pacific Programme for the Elimination of Lymphatic
Filariasis” in this area for over 20 years, but moreneeds to be done. People expect Institute of Tropical
Medicine (NEKKEN) should take a leading role in thisarea in Japan. Therefore, in fiscal year 2016, weestablished a center to promote drug development
and research in Neglected Tropical Diseases (NTDs)
to promote research activities and collaboration
between industry, academia and government.
How?
At WHO and G-7 Summit, industrialized countries,
as members of the global community, should be thevanguard in establishing NTDs measures.
What is most needed to control NTDs is a close
cooperation between developing countries impacted
by these diseases and advanced countries withresearch and development capabilities. Drawing on
this collaborative approach, we are pursuinginnovative research for diagnosis, treatment, andprevention methods.
To this end, it is essential to provide researcherswith comprehensive data and know-how to allow
them to discover the “seeds” that will lead from basic
research to preclinical and early clinical trials.
We have set the following goals, 1) providing
training courses with continuously updated knowledge
every year, 2) staying abreast of research trends andgrant availability, and providing researchers withnecessary information, 3) active promotion using

websites and e-mail magazines to widely disseminate
information on related research inside and outside the
NEKKEN. By improving the research environment inthis manner and by strengthening collaboration withprivate enterprise, we intend to promote a stable andsustainable research and development system.
What we are doing?
1. Training program management
Three educational programs (research ethics,
drug development, medical economics)>International Course on Research Ethics in May(3 days)>Diploma Course on Research & Developmentof Products to meet Public Health Needs inAugust (7 days)>Introductory course of health economy(planned)
2. Information Gathering>NTDi Center Symposiums organized with GHIT
and AMED>Establishment of R & D portfolio system>Present on going projects.
1) Anti Chagas compounds (Astellas)2) Measles based recombinant Dengue Vaccine(GHIT)
3) RAMP diagnostic Kit for Ebola (Toshiba)4) Simultaneous surveillance system for NTDs
by multiplex beads assay (AMED)
5) P
 OC system for yellow fever and Rift Valley
diagnostics (AMED:SATREPS)
6) House shield bed net (Sumitomo)
7) D iagnostic Kit for active infection of Schistosomasis(AMED)
8) Shiunko for cutaneous Leich maniasi (Ohkusa)9) A nti Malaria Kampo medicine (Toyama)10) A nti Malaria development based on an open
innovation platform (MEXT)
11) Pheumocaccal conjugate vaccine (Gates)
3. Nurturing promising research seeds
One of our mission is to support promissing projects
in our research stations of Kenya and Vietnam.
In 2016, we supported a schistosomasis epidemiology
research in Kenya and a collaborative research with
Toyama University on Kampo medicine.
4. Members
Leader and Professor Satoshi Kaneko
Committie at NEKKEN Juntra Laothavorn
Nguyen Huy Tien
Committie at N.U.
Yusuke Fujiwara(Center for Industry, University and Government coooperation)
Expert adviser
Kazuyo Ichimori(LF-NTD Unit)
Staff
Eiko Sanefuji− 30 −

LF-NTD Unit
Global efforts to control, eliminate or eradicate
neglected tropical diseases (NTD) are fast progressing
in recent years. Lymphatic filariasis (LF) is not an
exception. Under Global Programme to Eliminate
Lymphatic Filariasis (GPELF), endemic countries areprogressively scaling up interventions with partnershipat national and global levels towards the common goal
to eliminate the disease as a public health problem by
2020.
The purposes of this unit are to establish andkeep the data warehouse of the programme and tofoster professionals not only with knowledge but alsowith global vision who can contribute to the global
partnership to fight against LF and NTDs.
Activities:
1) Data collection and management
1. Collection and management of data and information
related to LF/NTDs from the world
2. Participation in and contribution to the expert
meetings related to LF/NTDs at national andglobal level4) Trainings on tropical disease control
1. Lectures and trainings for students and professionals
2. Publication of documents, development of training
materials and curriculum

5) “PacELF Endgame Project”
1. A joint project with James Cook University
2. D ata catalogue, Case studies, PacELF Way II
book

2) T
 he bridge between Japan and the world in thearea of tropical control
1. Establishment and maintenance of global network
2. Promotion Japan’s participation in the global
partnership

3) Advocacy and information dissemination in Japan
1. Lectures, meetings, media on tropical disease
control
2. Information sharing and exhibition to the generalpublic− 31 −

Director
AssistantKazuyo Ichimori
Yukiko Baba

Professor

Shinjiro Hamano

Office of Coordination for
Humanitarian Affairs(Introduction)
In 2016, the Office of Coordination for Humanitarian
Affairs was set up in our institute. Prof. Taro Yamamoto,who also heads the Department of International Health,was nominated as the first chief of this section. One
year has passed since its inception during which time
we have dispatched missions to natural disaster
affected areas and yellow fever epidemic areas.

make NEKKEN one of the leading organizations inJapan in terms of disaster relief activities.
Further, the infectious diseases team for Japanese
Disaster Relief was decided in a cabinet meeting in
October, 2015 based upon the fact that Ebola brokeout in West Africa in 2014 and there was an internationalcall for cooperation to help deal with it. NEKKEN is
expected to serve as one of the main stakeholders inthis field and was asked to participate on that team.
Because of all these events, setting up the Officeof Coordination for Humanitarian Affairs was proposed.

(Aims)
The aims of this office are to provide support toboth natural and manmade disaster areas. In orderto undertake these missions, this office shall develop
more human resources, do research, and become
the center of an international humanitarian network.
(Organization)
1. O ffice of Coordination for Humanitarian Affairs was
set up in NEKKEN
2. Appoint one section chief (professor)(Past, Present and Future)
NEKKEN has dispatched missions to disaster
afflicted areas such as Haiti in 2010, Tohoku region in2011 just after the East Japan Great Earthquake,West Africa in 2014 and Nepal 2015. These activities− 32 −

The University Hospital
Infectious Disease Ward
It was 16 June 1967 when the clinical departmentof the Institute of Tropical Medicine (NEKKEN)
established its department in the Nagasaki University
Hospital. Currently the NEKKEN department of clinicalmedicine has been running a clinic and providing inpatients care in the Department of Infectious Diseases
as “NEKKEN-NAIKA”. Our ward has 16 beds with 8
negative pressure rooms, of which two can accommodate
patients with BSL4 pathogens. We are specialized in
infectious diseases and also respiratory diseases; wetreat patients with systemic infectious diseases,
including tropical infectious diseases, HIV/AIDS,
tuberculosis, pneumonia, and various neoplasmic
and inflammatory respiratory diseases. We also
receive approximately 500 consultation cases a year
in other wards and give advices on diagnosis andtreatment. Outpatient clinic is open twice a weekwhere we run a travel clinic for international travelers.
For training and education, we provide a numberof lectures on infectious diseases and respiratory
diseases to undergraduate students and bed-side
training programs for resident physicians. We organize
a clinical case conference of tropical infectious diseases
as a part of Master of Tropical Medicine course, Schoolof Tropical Medicine and Global Health. Staff doctors
and resident doctors are regularly dispatched for along-term to abroad, San Lazao Hospital, the Philippines
and the infectious disease ward in Bac Mai Hospital,
Vietnam to accumulate our knowledge and experienceof clinical tropical medicine.

Professor
Associate Professor
Senior Lecturer
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Visiting Lecturer
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
AssistantGroup photo of staff members− 33 −

Koya Ariyoshi
Konosuke MorimotoTakeshi Tanaka
Yoshiro Yamashita
Masahiro Takaki
Emi Kitasyoji
Kensuke Takahashi
Akitsugu Furumoto
Mai Izumida
Satoshi Kakiuchi
Hiroyuki Ito
Hiroshi Nakaoka
Ikko Yasuda
Kosuke Matsui
Masahiro Sano
Akira Nishiyama
Kanako Shimamori
Ayako Matsuo

Number of Staff(as of May 1, 2017)

Divisions

Professor

Associate
Professor

Lecturer

Assistant
Professor

Sub total

Others

Total

Enrollment

14
[1]

6
(2) [1]

3

17
(19)

40
(21) [2]7(8)47(29) [2]※ ( ) number of fixed-term staff, [ ] number of concurrent staff

Accounting(Fiscal Year 2016)

Revenue

Expenditure
AmountDivisions

AmountDivisions(in thousands of yen)(in thousands of yen)

Administrative cost subsidy

772,269

Administrative cost subsidy

772,269

Non-subsidy income at Nagasaki University

161,815

Non-subsidy income at Nagasaki University

161,815

Joint Research

25,921

Joint Research

26,005External Commissioned Research
Fund
Commissioned Project

1,372,892

Endowment
Others949,551

42,695External Commissioned Research
Fund
Commissioned Project

12,618Endowment

22,335

4,100
Total

31,189Others2,392,310

4,100
Total

1,967,264

Grant-in-Aid for Scientific Research from the Ministry of
Education, Culture, Sports, Science and Technology(FY 2016)

Type of
Research

Scientific
Research(A)(General)

Scientific
Research(B)(Overseas
AcademicResearch)

Scientific
Research(B)(General)

Scientific
Research(C)(General)

Challenging
Exploratory
Research

Young
Scientists(B)

JSPS
Research
Fellow

Research
Activity
Start-up

Total

Numberof Grants

4

11

2

13

3

7

3

1

44

Amount40,43050,31011,70020,4105,330

12,480

3,730

1,430

145,820(in thousands)

Facilities & Administrative costs included− 34 −

Subsidy(FY 2016)

Type of
Research

National Bio-resource Project (NBRP)

Amount

4,100(in thousands)

External Fund(FY 2016)

Divisions

Joint Research with
Private Sectors

Commissioned
Research

Commissioned
Project

Endowments

Total

Number ofSources

9

32

8

18

67

Amount(in thousands)

25,921

1,372,892

42,695

12,6181,454,126

Facilities & Administrative costs included

Agreement of Educational, Scientific and Scholarly Exchange○Overseas
Name of organization of partner countries

Concluded date

Chiang Mai University (Thailand)
Mahidol University (Thailand)
National Institute of Hygiene and Epidemiology (Vietnam)
Airlangga University (Indonesia)
St. Luke’s Medical Center (Philippines)
San Lazaro Hospital (Philippines)
Kenya Medical Research Institute (Kenya)
Thammasat University (Thailand)
National Institute for Communicable Diseases of the National Health
Laboratory Service (South Africa)
China Medical University (China)
Jiangsu Institute of Parasitic Diseases (China)
National Institute of Malariology, Parasitology and Entomology(Vietnam)
University of the Philippines Manila(Philippines)
Patan Academy of Health Sciences(Republic of Nepal)

February, 1988
November, 1999
June, 2001
January, 2004
February, 2004
August, 2004
November, 2004
March, 2006
July, 2010
September, 2010
September, 2010
November, 2013
January, 2014
July, 2014

○Domestic
Name of organization of partner

Concluded date

The Research Institute of Tuberculosis Japan Anti-Tuberculosis Association
Nagasaki Prefectural Institute of Environment and Public Health

March, 2009
September, 2015

− 35 −

Telephone Number
Institute of Tropical Medicine, Nagasaki University ０９５（８１９）７８００
Extension
Dean ������������������������� ７８０１
Head of Administrative Office �������������� ７８０２
Section Leader��������������������� ４７１４
Chief of General Affairs Unit ��������������� ４７０２
General Affairs Unit������������������� ７８０３
Chief of Accounting and Facilities Management Unit ���� ４７０６
Accounting and Facilities Management Unit �������� ７８０７
Accounting and Facilities Management Unit �������� ７８１６
Chief of Overseas Research Station Unit���������� ４７０９
Overseas Research Station Unit ������������� ７８０６
Facsimile ����������������������� ７８０５
Meeting Room ��������������������� ７８７０
Department of Virology
Professor ������������������� ７８２７Associate Professor��������������� ８５８８
Information ������������������ ７８２９
Facsimile ������������������� ７８３０
Department of Emerging Infectious Diseases
Professor ������������������� ７８４８
Staff room ������������������� ７８４９
Information ������������������ ７８５１
Department of Bacteriology
Senior Assistant Professor������������ ７８３３
Information ������������������ ７８３１
Department of Protozoology
Professor ������������������� ７８３５
Lab.2 ��������������������� ７８３６
Lab.1 ��������������������� ７８３７
Information ������������������ ７８３８
Senior Assistant Professor������������ ７８１５
Department of Parasitology
Professor ������������������� ７８２２
Staff room ������������������� ７８２３
Facsimile ������������������� ７８２４
Information ������������������ ７８２５
Department of Immunogenetics
Professor ������������������� ７８１８Senior Assistant Professor������������ ７８４５
Information ������������������ ７８２０
Facsimile ������������������� ７８２１
Department of Pathology
Associate Professor��������������� ７９０３
Assistant Professor ��������������� ７８１４

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Department of Eco-epidemiology
Professor ������������������� ７８６６
Associate Professor��������������� ７８６７Lab.1 ��������������������� ７８５４
Information ������������������ ７８６６
Department of International HealthProfessor ������������������� ７８６９
Lab.1 ��������������������� ７８０８
Lab.2 ��������������������� ７８５３
Information ������������������ ７８６９
Department of Vector Ecology and Environment
Professor ������������������� ７８１０
Staff room ������������������� ７８１１
Information ������������������ ７８０９
Facsimile ������������������� ７８１２
Department of Clinical Medicine
Professor ������������������� ７８４０
Associate Professor��������������� ７８７３
Information ������������������ ７８４１
Information ������������������ ７８４２
Facsimile ������������������� ７８４３
Department of pediatric Infectious Diseases
Professor ������������������� ７７６３
Professor ������������������� ７２８４
Information ������������������ ７７６４
Department of Clinical Product Development
Professor ������������������� ７２８５
Information ������������������ ７５５８
Center for Infectious Disease Research in Asia and Africa
Kenya Research Station Professor �������� ７８６０
Kenya Research Station Assistant Professor ���� ７８３２
Vietnam Research Station Information������� ７８７６
Tropical Medicine Museum
Professor ������������������� ７８６８
Information ������������������ ７８６８
Central Laboratory
Electron Microscope Room ����������� ７８５９
Information ������������������ ７８５７
NEKKEN Bio-Resource Center Information��������� ７８５６NTD Innovation Center
Information ������������������ ４７０７
LF-NTD Unit ���������������������� ８５８９
Office of Coordination for Humanitarian Affairs
Information ������������������ ７８６９

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㎡− 38 −

Location map of Institute of Tropical Medicine,
Nagasaki University in Nagasaki City

How to get the Institute▲▲○From JR Nagasaki Station
Electric Tramway Nagasaki Station (bound for Akasako) → Hamaguchi-machi → about 10-minute walkNagasaki Bus Nagasaki Station (No.8 bound for Shimoohashi via School of Medicine) → School of Medicine▲○From JR Urakami Station
Electric Tramway Urakami Station (bound for Akasako) → Hamaguchi-machi → about 10-minute walk▲

○From Nagasaki Airport
Kenei Bus Nagasaki Airport No.4 Bus Stop (For Nagasaki Sta. (via Showa-machi / via Showa-machi ・ Sumiyoshi))→ Hamaguchi-machi → about 10-minute walk
Location
1-12-4 Sakamoto Nagasaki 852-8523
URL http://www.tm.nagasaki-u.ac.jp
Published on July 2017
Edited by Institute of Tropical Medicine, Nagasaki University
Printed by In-tex Co.,Ltd. 6-3 Saiwai-machi Nagasaki 850-0046 Tel: +81-95-826-2200