Location map of the Institute of Tropical Medicine,
Nagasaki University in Nagasaki City

INSTITUTE OF TROPICAL MEDICINENAGASAKI UNIVERSITY

Mt. Inasa

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Ropeway

Nagasaki Bay

Urakami

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og

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for Akasako−
OhashiuraHamaguchi-machi
Urakamieki-mae
Nagasaki−
Ohato

Igakubu-mae

Nagasakieki-mae

School of
Dentistry
University
Hospital

School ofMedicine

Urakami−tenshudo-mae

Isibashi
Tsukimachi

Prefectural OfficeInstitute of Tropical
Medicine

City Hall−−
Chuobashi−−
Kokaido-mae
Suwajinja-mae−
Shokakuji-shita

JR Kyushu
Streetcar
Main bus routfor Mogi

for Hotarujaya

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熱研案内パンフ（欧文）表紙４−１ CMYK 山道 芦塚 加藤 宮副SEPTEMBER

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Published on September３
０，
２
０
０
６
Edited by Institute of Tropical Medicine, Nagasaki University
Printed by Showado Printing Co.,１００７‐２ Nagano machi, Isahaya８
５
４
‐
０
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３
６，Japan

ME

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How to get the Institute
１．From Nagasaki Station （JR Kyushu）!Get on a bus (Nagasaki Bus, Line ８）at Nagasakieki-mae and get off at Igakubu-mae.
Five minutes walk from the bus stop.
"Get on a streetcar at Nagasakieki-mae（for Akasako, Line １or３）, and get off at
Hamaguchi-machi. Ten minutes walk from the streetcar stop.
#Ten minutes by taxi from the station.
２．From Urakami Station（JR Kyushu）!Twenty minutes walk.
"Five minutes taxi.
３．From Nagasaki Airport!Get on limousine at the airport（for Nagasaki）, and get off at Nagasaki-ekimae, andthen continue to１．
"Get on limousine at the airport（for Nagasaki）, and get off at Ohashi, and then twenty
minutes walk from the bus stop or ５ minutes by taxi.
#About one hour by taxi from the airport.
Location
１‐
１
２‐４ Sakamoto Nagasaki ８５２‐
８５２３
URL http://www.tm.nagasaki-u.ac.jp

ER

S

背は２mm
（決定：宮副）MISSION STATEMENT
Institute of Tropical Medicine, Nagasaki University

The tropics, the most ecologically diverse region on the Earth, presents an ongoing complexity of tropical diseases and other health problems. In view of the remarkable advances made in
the field of international exchange in recent years, it is imperative that these problems be addressed from a global perspective.
Based on this understanding, the Institute of Tropical Medicine, Nagasaki University, aims
to overcome tropical diseases, particularly infectious diseases, and the various health problems
associated with them, in cooperation with related institutions, to strive for excellence in the following areas:
１．Spear-head research in tropical medicine and international health
２．Global contribution through disease control and health promotion in the tropics byapplying the fruits of the research
３．Cultivation of the researchers and specialists in the above fields

General view of the Institute
Coverpage: Growth monitoring of young children in Savannakhet Province, Lao, P.D.R.
(Health Development Study in Lao, P.D.R.)

熱研案内パンフ（欧文）表紙２−３ CMYK 山道 芦塚

背は２mm（決定：宮副）Preface
The Institute of Tropical Medicine, Nagasaki University, established in
1942, is a unique government-assisted institution for the research on tropical
medicine, both in the basic and applied fields. Its reorganization led to thefirst collaborative institute in medical science in Japan in 1989, and designation as one of the Centers of Excellence in 1995 by Ministry of Education, Science and Culture. Present organization of the institute is composed of 3 major
research fields (11 departments, 1 domestic visiting department, 1 overseas
visiting department), 2 centers, and 1 clinical unit.
According to the first external review in 1996, the institute worked out
its Mission Statement as shown on a back cover. To fulfil our mission, we continue the research and other related activities. The highlights are as follows.
＊Activities on the Mission Spear-head research in tropical medicine and international health
１．Strategic researches have been conducted to develop the novel weapon against tropical diseases; analysis
of genomic structure of Japanese encephalitis and dengue viruses, structure and function of the receptors forbacterial enterotoxins, mechanisms for expression and activation of superoxide degenerating NADPH oxidase system, and immuno-genetical analysis of tropical diseases.
２．Epidemiological studies and control have been carried out on malaria, dengue fever / dengue hemorrhagic
fever, SARS acute respiratory infections, Kaposi's sarcoma and schistosomiasis in Southeast Asia and Africa.
３．Environmental factors, such as vector and socio-economic problem, which cause the spread of tropical diseases in the developing countries have been studied.
＊Activities on the Mission Global contribution through diseases control and health promotion in the tropics
by applying the fruits of the research
１．When the world was suffering from a severe outbreak of SARS in 2003, the institute dispatched 3 researchers to P.R. China and other countries in respond to a request of WHO.
２．And in 2005, the institute dispatched the investigation team to make a survey of possible outbreak of infectious diseases in Indonesia and Sri Lanka, the countries that met disaster of tsunami.
Thus the staffs have given their technical co-operation to disease control program in developing countries as
WHO short-term consultants, JICA experts and other consultants.
＊Activities on the Mission Cultivation of the researchers and specialists in the above fields
１．Staffs of the institute conduct the doctorate and master degree course which belongs to Graduate Schoolof Bio-medical Sciences in Nagasaki University.
２．Since 1978, the institute offers a 3-month course of Tropical Medicine and Related Studies.
３．Since 1983, the institute holds one year training course for foreign participants entitled Research in
Tropical Medicine sponsored by JICA.
Based on the achievement mentioned above, in１９９３，Department of Virology has been designated as WHO
Collaborating Centre for Reference and Research on Tropical Viral Diseases, and since２０００the Institutehas played a role of core university in JSPS cooperative research program with Vietnam.
In２０
０
３，
Institute of Tropical Medicine and Graduate School of Biomedical Sciences made a joint application to the 21st Century Center of Excellence Program supported by Ministry of Education, Culture, Sports,
Science and Technology. Our research program Global Control Strategy of Tropical and Emerging Infectious
Diseases successfully obtains a Governmet Grant of 5 years.
In 2005, the overseas research laboratories of the Institute of Tropical Medicine has been established in
Kenya Medical Research Institute, Nairobi, Kenya and National Institute of Hygiene and Epidemidogy, Hanoi,
Vietnam. The overseas research laboratories promise an extensive and longitudinal studies on tropical diseases.
In addition, the institute has a home page by which we educate the public why tropical medicine is important for the future well being of humankind and information on the tropical diseases in the world.
This pamphlet is one of our advocacy efforts to the public. It offers a brief but intelligible explanation on
our research activities and other related social activities. Any suggestions and supports will be gratefully appreciated.
September, 2006
Yoshiki Aoki M. D., D. M. Sc.
Dean and Professor
Institute of Tropical Medicine
Nagasaki University―１―

Contents
Preface…………………………………………………………………………………………１
Contents …………………………………………………………………………………………２
Historical Review ………………………………………………………………………………３
Successive Deans of the Institute……………………………………………………………４
Organizational Chart…………………………………………………………………………５
Collaboration research………………………………………………………………………６
Institute of Tropical Medicine Steering Committee………………………………………７
Institute of Tropical Medicine Collaboration Professional Committee…………………８
Character of research organization and activities…………………………………………９
Postgraduate School…………………………………………………………………………９Three-month Course on Tropical Medicine and Related Studies…………………………９Training Course in Research of Tropical Medicine …………………………………………１
０
Public communication…………………………………………………………………………１
０
Publications……………………………………………………………………………………１
０
The 21st Center of Excellence Program Global Control Strategy of Tropicaland Emerging Infectious Diseases (2003-2007)……………………………………………１
１
Department of Virology………………………………………………………………………１
２
Department of Bacteriology…………………………………………………………………１
３
Department of Protozoology…………………………………………………………………１
４
Department of Parasitology…………………………………………………………………１
５
Department of Thermal Adaptation…………………………………………………………１
６
Department of Host-Defense Biochemistry …………………………………………………１
７
Department of Pathology/Division of Clinical Investigation ………………………………１
８
Department of Internal Medicine……………………………………………………………１
９
Department of Preventive Medicine and AIDS Research…………………………………２
０
Department of Vector Ecology & Environment……………………………………………２
１
Department of Social Environment…………………………………………………………２
２
Department of Immunogenetics………………………………………………………………２
３
Clinic at the University Hospital……………………………………………………………２
４
Animal Research Center for Tropical Infections ……………………………………………２
４
Research Center for Tropical Infectious Diseases …………………………………………２
５
Central Laboratory ……………………………………………………………………………２
６
Infectious Diseases Research Program Nairobi Research Station, Kenya(A Special Grant from the Ministry of Education, Sports, Culture, Scienceand Technology, 2005〜2009) …………………………………………………………………２
７
Research Center: Clinical Epidemiology of Emerging and Reemerging Infectious
Diseases Laboratory in Hanoi, Viet Nam (A special research program of
the Japanese Government for the establishment of a research centerfor emerging and reemerging infectious diseases, 2005〜2009) ……………………………２
８Japanese support to the Pacific Immunization Program Strengthening (J-PIPS)
Suva, Fiji………………………………………………………………………………………２
９Administration …………………………………………………………………………………３０
Number of Staff …………………………………………………………………………………３０
Accounting …………………………………………………………………………………………３
０
Grant-in-Aid for Scientific Research from the Ministry of Education,
Culture, Sports, Science and Technology ………………………………………………………３
１
External Funding …………………………………………………………………………………３
１
Site and Buildings…………………………………………………………………………………３
１
Agreement of Educational, Scientific and Scholaly Exchange ………………………………３
１
Location map of the Institute of Tropical Medicine on Sakamoto Campusof Nagasaki University …………………………………………………………………………３
２
Telephone Number……………………………………………………………………………３
３―２―

Historical Review
The Institute of Tropical Medicine, Nagasaki
University was originally founded in March 1942 as
the East Asia Research Institute of Endemics, Nagasaki Medical College in order to perform basic andapplied studies on endemic diseases in East Asia. At
the beginning, most of its research activities werefield studies conducted in mainland China by the Departments of Pathology, Bacteriology, Internal
Medicine, and Dermatology of Nagasaki Medical College. August 9 th, 1945, the atomic bomb was dropped
in Nagasaki, and the Institute's all the facilities andresearch materials were completely destroyed together with Medical School. Consequently, the development of the Institute and its research activities
had lagged significantly behind.
In April, 1946, the Institute changed its name to
the Research Institute of Endemics, Nagasaki Medical College, and moved to Isahaya City in May to resume research activities. Yet in accordance with the
National School Establishment Law issued in May,
1949, the Institute once again changed its name to the
Research Institute of Endemics, Nagasaki University.
In 1957, the Institute was affected by another disaster of massive flooding, and its facilities, equipment,
and research materials were severely damaged. Thus,
construction of a new building started in Sakamoto,Nagasaki City in 1960, and the Institute moved to thebuilding in April of the following year. The Institute's Departments, which were only two at the time,
Pathology and Clinics, increased its number every
year after 1963, including Epidemiology, Parasitology, and Virology. The Sakamoto building finishedits first expansion at the end of 1966.
In June, 1967, with the partial alteration of the
National School Establishment Law, the name of theInstitute was changed for the third time to the present one to carry out basic and applied studies on
tropical medicine. Around the same time, the Department of Internal Medicine, Institute of Tropical

Medicine, equipped with 20 beds, was opened in the
University Hospital. In 1974, the Department of Bacteriology and the Reference Center were attached,and in 1978, the Department of Preventive Medicine,consisting mainly of visiting professors, associate
professors, and researchers, and the Tropical Medicine Training Course were launched. In the ensuing
year, the Infectious Animals Deprivation Experiment
Laboratory was promoted to become the Animal research Center for Tropical Infections, and the second building expansion was concluded in March, 1980.
In September, 1983, a JICA-sponsored group training program Tropical Medicine Research Course
was opened, the Department of Protozoology was established a year after, and the third building extension was finished in July the year after that. Twoyears later, the Department of Medical Entomology
was created and the Institute was reorganized into
the collaborative institute in another two years. In
1991, the Department of Biochemistry was added,
and the fourth building expansion was ended in
March, 1994. In April, 1994, the Institute was divided into three big Divisions, Tropical Microbiology,
Pathogenesis and Clinical Sciences, and Environmental Medicine, with the establishment of two newresearch Departments, Thermal Adaptation and Social Environment, which have expanded to 12 Departments at present. The Institute was designated asCenter of Excellence in the forefront of scientificresearch in 1995, and a new research Department,
Molecular Epidemiology, was established under the
Research Field of Microbiology in 1996 to invite
overseas visiting professors. In 1997, the Reference
Room for the Tropical Medicine was replaced by the
Tropical Disease Information and Reference Center,and it was again succeeded by the Research Center
for Tropical Infectious Disease in 2001. In March,
2003, when the Sakamoto building finalized its fifth
expansion, its extension work of almost 40 years
came to an end. In March, 2006, the main building's
repair work was completed.

―３―Successive Deans of the Institute（East Asian Research Institute of Endemics）
Susumu Tsunoo

May．
４，
１
９
４
２-Aug．
２
２，
１
９
４
５

Kohei Koyano

Dec．
２
２，
１
９
４
５-Jan．
２
３，
１
９
４
８

Kiyoshi Takase

Jan．
２
４，
１
９
４
８-Aug．
３
１，
１
９
４
８

Noboru Tokura

Sept．
１，
１
９
４
８-May．
３
０，
１
９
４
９

（Research Institute of Endemics）
Noboru Tokura

May．
３
１，
１
９
４
９-Aug．
３
１，
１
９
５
８

Nanzaburo Omori

Sept．
１，
１
９
５
８-Nov．
３
０，
１
９
６
３

Hideo Fukumi

Dec．
１，
１
９
６
３-May．
３
１，
１
９
６
７

（Institute of Tropical Medicine）
Hideo Fukumi

June．
１，
１
９
６
７-Nov．
３
０，
１
９
６
９

Daisuke Katamine

Dec．
１，
１
９
６
９-Nov．
３
０，
１
９
７
３

Kaoru Hayashi

Dec．
１，
１
９
７
３-Nov．
３
０，
１
９
７
７

Tatsuro Naito

Dec．
１，
１
９
７
７-Nov．
３
０，
１
９
７
９

Daisuke Katamine

Dec．
１，
１
９
７
９-Apr．
１，
１
９
８
１

Keizo Matsumoto

Apr．
２，
１
９
８
１-Apr．
１，１
９
９１

Hideyo Itakura

Apr．
２，
１
９
９
１-Apr．
１，
１
９
９３

Mitsuo Kosaka

Apr．
２，
１
９
９
３-Apr．
１，
１
９
９
７

Akira Igarashi

Apr．
２，
１
９
９
７-May．
３
１，
２
０
０
１

Yoshiki Aoki

Apr．
１，
２
０
０
１-Up to the present―４―Organizational Chart
Department of Virology
Department of Bacteriology
Research Field ofMicrobiology

Department of Protozoology
Department of Parasitology
Department of Molecular Epidemiology(Overseas Visiting Professor)
Department of Thermal Adaptation

Research Field ofPathogenesis
and Clinical
Sciences
Dean

Faculty
Meeting

Research Field ofEnvironmental
Medicine

Department of Biochemistry
Department of Pathology
Department of Internal Medicine
Department of Preventive Medicine
and AIDS Research
Department of Vector Ecology& Environment
Department of Social Environment
Department of Environmental Physiology

Attached
Facilities

Overseas Research
Stations
Administration

Animal Research Center
Research Center for
Tropical Infectious Diseases
Central Laboratory

General Affairs Unit
Collaboration Research Unit

University
Hospital

Clinical
Department

Nagasaki University
Nairobi Research Station
NUITM-KEMRI Project
Nagasaki University
Hanoi Research Station（NIHE-Nagasaki University
Friendship Laboratory）
Nagasaki University
Fiji Research Station

Department of Internal Medicine―５―These activities of the institute are expected toCollaboration researchcontribute to remarkable progress of tropical medicine.

The institute has conducted research in the field

The senior staff composed of professors of theof tropical medicine for the past ６
２ years since its

institute and the executive committee make plans forestablishment in１
９４
２．The institute was reorganizedresearch work. The steering committee and the col-to make extensive collaboration with other universi-

laboration professional committee composed of expe-

ties and institute in the field of interdisciplinary

rienced scientists coordinate the various collabora-

tropical medicine with molecular biology, entomology,tion researchs.

anthropology, social medicine, etc.

Collaboration Research Sytem

Steering Committee

The senior
staff（Professors）

Collaboration professional
committee

Executive committee―６―

Institute of Tropical Medicine Steering Committee
Nagasaki University

Professor Emetitus

Akira Igarashi

Duputy Director

Takeshi Kurata

National Institute of Infectious Diseases
International Medical Center

President

Takehiko Sasazuki

Keio University School of Medicine

Professor

Tsutomu Takeuchi

Research Institute for Humanity and Nature

Director

Toshitaka Hidaka

Research Institute for Microbial Diseases Osaka University
Professor

Takeshi Honda

National Museum of Ethnology
Director−General

Makio Matsuzono

Director

Tadashi Yamamoto

PegentShigeru Katamine

Graduate School of Biomedical Sciences

Dean

Masao Tomonaga

Institute of Tropical Medicine

Dean◎Yoshiki Aoki〃

Professor

Kouich Morita〃

Professor

Toshiya Hirayama〃

Professor

Hiroji Kanbara〃

Professor

Michio Nakamura〃

Professor

Takuya Iwasaki〃

Professor

Koya Ariyoshi〃

Professor

Naoki Yamamoto〃

Professor

Masahiro Takagi〃

Professor

Tsutomu Mizota〃

Professor

Kenji Hirayama〃

Professor

Masaaki Shimada〃

Professor

Kazuhiko Moji

The Institute of Medical Science
The University of Tokyo

Nagasaki University◎：Chairman―７―Institute of Tropical Medicine Collaboration Professional Committee
The Institute of Medical Science The University of Tokyo
Professor

Aikichi Iwamoto

Meiji Gakuin University The Faculty of International Studies
Professor

Akira Oki

Graduate School of Medicine The University of Tokyo
Professor

Kiyoshi Kita

Graduate School of Veterinavy Medicine, Hokkaido University
Professor

Ikuo Takashima

Chiba University Research Center for Pathogenic and Microbial Toxicoses
Professor

Kazuko Nishimura

Tsuda College Undergraduate Courses

Professor

Chizuru Misago

Kobe University Graduate School of Medicine

Professor

Haku Hotta

Center for Integrated Area Studies (CIAS), Kyoto University
Assistant Professor

Kenichi Abe

Nagasaki University
Faculty of Fisheries

Professor

Kazumi Matsuoka

Graduate School of Biomedical Sciences

Professor

Isao Kouno

Institute of Tropical Medicine

Professor

Kouichi Morita〃

Professor

Toshiya Hirayama〃

Professor

Hiroji Kanbara〃

Professor

Yoshiki Aoki〃

Professor

Michio Nakamura〃

Professor

Takuya Iwasaki〃

Professor

Koya Ariyoshi〃

Professor

Naoki Yamamoto〃

Professor ◎Masahiro Takagi〃

Professor

Tsutomu Mizota〃

Professor

Kenji Hirayama〃

Professor

Masaaki Shimada◎：Chairman―８―system the Graduate School of Medical Science,

Character of researchorganization and activities

Dental Science and Pharmacology were integrated
into the Graduate School of Biomedical Science consisting of four courses. All the departments in the In-

Based on the following research organization

stitute belong to the Course of Infection Research.

and intimate linkages with other research institutes

Students who want to study tropical medicine in theand universities, the institute aims at accomplishing

Institute are required to apply to the office of thea mission

Graduate School of Biomedical Science through theSpear-head research in tropical medicine

and international health .

professor of each department.

● To study comprehensively the tropical diseases

In addition to the PhD course, in 2006 Master ofwhich are raging in the developing countries, re-Tropical Medicine (MTM) course opened in the Na-

search organization of the institute consists of 3

gasaki University graduate school of Biomedical Sci-

major research fields which deal with the classicalence and 12 students from various countries were ad-

triad ofhuman-agent-environment determinants

mitted to the school in April. The curriculum is con-of infectious diseases and Research Center for

structed by three parts namely (1) 4 months lecture

Tropical Infectious Diseases.

and practice on Clinical Trop Med and Tropical Pub-

● The research of tropical medicine faces the inevi-lic Health, (2) 1 month oversea training on tropicaltable fact that the bench is in the bush . There-

clinical medicine and public health in Thailand, Viet-fore the institute has a close linkage with the over-nam and or Philippines, and (3) 6 months dissertationseas institutes in Asia, Africa and South Americas

preparation for each student's subject.

and continues the joint studies. Memorandums of

For the clinical training in the tropics, we set up

academic exchange programs were signed between

2 weeks training course at three affiliated hospitals,

Nagasaki University and 8 overseas institutes.

Chianmai University Hospital, Thailand, Choray

Since the overseas research laboratories of the in-

Hospital, Ho Chi Minh City, Vietnam, and San

stitute has been established in Kenya Medical Re-

Lazaro Hospital, Manila, Philippines. The applica-

search Institute, Kenya and National Institute oftion from is available through our homepage. Briefly,

Hygiene and Epidemiology Vietnam in 2005, thethe applicant should have more than two years clini-

extensive and longitudinal studies on tropical dis-

cal training as a medical doctor, and should haveeases will be promoted. The exchange program un-enough communication skill in English.

der the core university system of JSPS established between our Institute and National InstituteThree-month Course on Tropical
Medicine and Related Studies

of Hygiene and Epidemiology in Vietnam in 2000
has been renewed in２
００５and lasts for 5 years more.
● The prevalence of tropical diseases depends onthe geographic, social and economic factors.

This is the only one short-course of tropical

Therefore the institute has established the special

medicine in Japan. This course aims to support medi-

research system which helps forward the multidis-

cal and paramedical personnel who are working or

ciplinary studies on tropical diseases.

will work in the tropics by providing opportunities tolearn a broad range of skills and knowledge relevant
to practicing medicine, conducting disease control

Postgraduate School

programs and conducting medical research in tropical and developing countries.

In April, ２００２, the system of Doctor Courses in

The course began in 1978. Up to the 28thcourse

Nagasaki University has been changed. In the newheld in 2005, 321 personnel (including 132 medical―９―

nurses,of endemic and epidemic diseases infesting the Tor-

community-health nurse, midwives, pharmacist) fromrid Zone. Through the guidance of the staff of the In-

all over Japan have completed the course. Fifteen

stitute, the participants will enrich their fundamental

participants are accepted to attend the course in eachknowledge and practical techniques for various medi-

year. The course is run by the steering committee,

cal problems in the tropics.

doctors,

and 189 paramedical

such

as

Individual participants will study on a selectedwhich consists of members from both inside and out-

subject in the responsible department for a year. Ca-side the Institute of Tropical Medicine (ITM).
The full-time staff member of the ITM and several guest lecturers provide the 14 weeks (June topacity of each department is normally limited to one
person.

August) of lectures, laboratory practicals and fieldwork in the field of virology, bacteriology, protozool-

Public communication

ogy, parasitology, medical entomology, environmental
physiology, biochemistry, pathology, host-genetics,
epidemiology, human ecology, social medicine, clini-

We hold lectures for the citizens with an irregu-

cal medicine and also geography and culture in trop-

lar schedule. Pupils and students are invited every

ics. Participants who completed the course success-year to learn tropical medicine at our museum, by

fully are awarded the Diploma in Tropical Medicine.

audiovisual aids and by lectures.
To accumulate know-how of risk communication
on tropical infectious diseases in our institute, weare planning to introduce a science cafe where wehave frank communication with the citizens on thepresent state of tropical medicine.

Publications
Our major publications are Bulletin of Nagasaki

Admission ceremony in 2006

University Institute of Tropical Medicine (In Japanese, yearly since 1964, compiled from 1971-1979,

Training Course in Researchof Tropical Medicine

PDF is available at HP), Brochure (Both in Japaneseand English, since 1977, PDF is available at HP) and
Report of collabolative study (since 1989). Special

Arrangements for conducting the course in thisInstitute are administered by Japan International

memorial volumes of the 20 th, 30 th and 60 th anniversary were also published.

Cooperation Agency, commissioned by the Govern-

The publication of our English Science Journal,

ment of Japan to execute Technical Cooperation Pro-

Tropical Medicine (since 1967), was suspended sincegrams from１９８
３．

2002. Annals of Endemic Diseases (from 1959-1966),This course is conducted by the Government of

the predecessor of Tropical Medicine, is being input

Japan as a part of its Technical Cooperation Pro-to the electronic database of University Library.

grams for developing countries with a view of con-Literatures and documents being kept for decades intributing to upgrading their standards in tropicalour depository will soon be open at our HP.

medicine and to promoting friendly relations to thecountries.
The purpose of this course is to help the control―１０―The 21st Center of Excellence Program
Global Control Strategy of Tropical andEmerging Infectious Diseases (2003-2007)
Outline of the program
Tropical and Emerging Infectious Diseases havebeen posing public health problems and social andeconomic burdens on developing countries. The urgent need for countermeasures, therefore, has been
longed for. This program aims at developing tools
and strategies for the control of 10 major infectious
diseases: malaria, dengue fever, West Nile fever,schistosomiasis, cholera, prion disease, HIV/AIDS,
drug-resistant infectious diseases, Helicobacter
pyroli -infection, and SARS, and at cultivating researchers and specialists in the field.
The research project features three kinds of interactive studies such as laboratory vs. field, basic
vs. clinic, and developing countries vs. advanced
countries. The research members are grouped undersix major pathogens: virus, bacteria, fungus, prion
protein, HIV, and parasite. The organizing committeeof the program makes sure that those six groups keep
close contact with each other, and carry out other responsibilities including international symposia, publicity, and academic agreements between Nagasaki
University and other overseas research institutes.
Highlights of research and education completed so far
Research works in the area where the diseases
exist１）Genetic factors that control the gravity of ma-

laria and dengue hemorrhagic fever２）Hidden morbidity of schistosomiasis haemtobia
３）Mechanism of thrombocytopenia caused by dengue hemorrhagic fever４）Drug-resistance mechanisms of respiratory infectious diseases５）Some factors that induce endemic or epidemic
malaria
Strategic research including the development of diagnostic tools, drugs, and vaccine
１）Miniature pigs as disease models for schistosomiasis japonicum２）Protective immunological response against
liver-stage malaria parasites３）Pathogenesis of Cryptococcus neoformans４）Mechanism of gastric mucosa injured by H. pylori vacuolating cytotoxin５）Mechanism of retrovirus invasion of the cells６）Development of anti-prion drugs by bioinformatics and screening of sea weeds７）Development of diagnostic kits for West Nile fever and SARS
８）Development of vaccine for West Nile fever９）Development of the method for evaluation ofmosquito control using satellite landscape
Cultivation of human resource１）A total of 30 medical doctors took clinical training programs conducted at the Hospital of ChenMai University in Thailand as well as SanLazaro Hospital and St. Luke's Medical Centerin Philippines.
２）In April, 2006, the Master Course of Tropical
Medicine (one-year course) was established in
Nagasaki University.

Tropical
Diseases

Emerging
Diseases

Malaria,West Nile Fever, Drug
Prion Disease
Helicobacter
Schistosomiasis,
Resistant Bacteria
Pylori
Dengue Fever, Cholera
Developing Countries
Developed Countries
Collaborating
Exchange
Hospitals
Program
Chianmai University
Hosp（Thailand）
Institute of
St. Lukes Medical
Tropical Medicine・Center （Philippines） Graduate School of
Biomedical Sciences

Center for
Infectious
Diseases,
Nagasaki
University
Hospital

Basic Research
Field Bases
Collaborating
Translation Center organizations
NIHE（Vietnam）
JICA Ronbok
WHO, JICA,
Product Development CDC, NIH（Indonesia）
RITM（Philippines）
Liverpool
KEMRI（Kenya） Intervention Research Trop.Med
IMR （Malaysia）
Thammasat Univ.
Production of New Strategies
and Human resources
Global Control of Infectious Diseases―１１―WHO Western Pacific Region (WPR) designated, theDepartment of Virology

Department of Virology, Institute of Tropical Medicine, Nagasaki University as a WHO CollaboratingThis Department has been conducting basic andCenter for Reference and Research on Tropical Vi-

applied research on mosquito-borne flaviviral dis-ral Diseases on 23 Nov. 1993. On 9 August 1994, theeases such as Japanese encephalitis (JE), dengue fe-

Inauguration Ceremony was held at the Pompe Hallver (DF) / dengue hemorrhagic fever (DHF), as wellwith Dr. Han and approximately 120 guests in atten-

as SARS virus.

dance, this was followed by the WHO Workshop
Epidemiology and Control on DF /DHF and JE .

Analysis on the structure and function of JE and dengue viral genome

The Department has received WHO fellows from Vietnam, Fiji, and the Philippines, and dispatched

Nucleotide sequence analysis and molecular ex-

WHO short-term consultants on the subjects rele-pression of JE and dengue viral genome have beenvant to its terms of reference. Dr. Kouichi Morita

carried out together with long PCR techniques in or-

was appointed as the Regional Adviser on Communi-

der to study molecular epidemiology, epitope analy-

cable Diseases, WHO/WPR, from 16 May 1995 to 15

sis, biological activity of nonstructural proteins, andMay 1998. Dr. Futoshi Hasebe was dispatched to thevirulent viral gene responsible for viral pathogenesis.

WHO Western Pacific Regional Office to collaboratein the global emerging infectious disease control pro-

Analysis on apoptosis induced by flavivirus infections.

gram from March 2004 to March 2006.

Flavivirus infection induces apoptosis of the infected cells. Characterization of apoptosis and its

Professor

Kouichi Morita

relation to pathogenecity has been studied in cell line

Associate Professor

Futoshi Hasebe

and animal model.

Visiting Associate Professor

Maria del Carmen Parquet

Research Associate

Shingo Inoue

Guest Research Fellow

Nabeshima Takeshi

Viral genome detection and identification by

Guest Research Fellow

Edward G. Mathenge

PCR and LAMP methods, preparation of diagnostic

Guest Research Fellow

Yu Fuxum

antigen from infected cell culture fluid, and simplifi-

Technician

Kazumi Jodai

cation of IgM antibody detection have been carried

Postgraduate student

Hitomi Kinoshitaout.

Postgraduate student

Guillermo Posadas Herrera

Research Student

Mya Myat Ngwe Tun

Development of rapid diagnosis of flaviviral diseases

Activities as a WHO Collaborating Center
Dr. S. T. Han, former Regional Director of

Newly identified JE neutralizing epitope 503

P 2 Level laboratory―１２―

Department of Bacteriology
Our major research interest is to elucidate the
etiologic agents isolated from pathogenic bacteria
related to the worldwide emerging and re-emerging
diseases.
Studies on the cellular and molecular mechanisms of diarrhea induced by bacterial enterotoxins and Salmonella :Aeromonas sobria hemolysin is important in thepathogenesis of diarrhea caused by this enteropathogenic
bacterium .
Glycosylphosphatidylinositolanchored glycoprotein was identified as a receptor
for A. sobria hemolysin on Intestine 407 cells (Int. J.
Med. Microbiol (2005) 294, 427).
Focusing on the molecular mechanisms of the diarrhea induced by heat-stable enterotoxins (STa) ofenteropathogenic bacteria, we are studying 1) interaction of Escherichia coli heat-stable enterotoxin
with its receptor and 2) activation of guanylate cyclase (GC-C) by STa. Inflammation caused by Salmonella is also investigated (J. Biol. Chem. (2004) 279.
１２２
１
３ J. Immunol. (2004) 172：3051)
Studies on the pathogenesis of Helicobacter pylori :To investigate a potential mechanism of how H.
pylori establishes infection, we investigates the hostparasite relationships of H. pylori , focusing on vacuolating cytotoxin A (VacA) and Cag pathogenicity island (CagPAI).
１）
In cells transiently transfected with acarboxyl-terminal transmembrane domain (dominantnegative) syntaxin 7 mutant, VacA failed to induce
vacuolation, suggesting that SNARE is involved intheintracellular vacuolation induced by VacA (J.Biol.
Chem. (2003) 278:25585-25590).
2）
VacA induced bone marrow-derived mast cells
to produce proinflammatory cytokines, TNF-alpha,macrophage-inflammatory protein-lalpha, IL-1 beta,
IL-6,IL-10,and IL-13 in a dose-dependent mannerwithout causing degranulation (J. Immunol.(2002)168:
2603-2607)．

3）
Mice deficient in protein tyrosine phosphataseb do not show mucosal damage by VacA, although VacA is incorporated into the gastric epithelial cells to the same extent as in wide-type mice (J.
Biol.Chem(2003)278:19183) ibid (2004) 279: 7024,
ibid (2004) 279: 51013 Nat. Genet.(2003)33:375-381)．
In addition, we found that VacA induces cell
death through Bax and Bak activation leading to cytochron C release (J. Biol. chem. (2006) 281:11250)
4）
Human β-defensin-2 (hBD-2) is an antimicrobial peptide which belongs to one of the most important host defence system against bacterial infection
in several epithelial tissues. We studied the effect of
H. pyloli on the expression of hBD-2 mRNA in MKE
45 gastric mucosal cells. H. pylori , but not culture
filtrate, increased hBD-2 mRNA level in MKN 45
cells, whereas thus inductive effect of H. pylori was
not detected when Intestine 407 cells were incubatedwith H. pylori . Among the tested strains of H. pylori ,which lacks Cag PAI, did not induce hBD-2 mRNA in
MKN 45 cells. These results suggested that cag PAIof H. pylori is important for inductive expression of
hBD-2 mRNA through NF-KB activation in MKN 45
cells.
Exposure of MKN 45 cells to Salmonella typhimurium, S. enteritidis , S. typhi , and S. dublin ,but not Escherichia coli ML 35, resulted in remarkable induction of hBD-2 mRNA. (Cell. Microb. (2001)
3: 115 J. Immuml (2004) 173: 5398)
Studies on the development of cholera vaccine:The overexpression of fimbriae of Vibrio cholerae
O 1 is under study for use in cholera vaccine trial.

Cytotoxicity of VacA toxin through its binding toreceptor-protein tyrosine phosphataseβ―１３―Professor
Toshiya Hirayama
Assistant Professor Akihiro Wada
Research Associate
Masahiko Ehara
Technologist
Mamoru Iwami
Postgraduate Student Jyunzou Hisatsune
Researcher
Eiki Yamasaki
Technician
Kayo Maeda
COE TechnisianKumi Tamura

Laboratory

Study of trypanosomes

Department of Protozoology

１）Functions and expression mechanism of transsialidase.

Our main purpose is to clarify infection mecha-

２）Adaptation mechanisms of Trypanosoma species
to environments.

nisms of intracellular protozoan parasites.

３）Modification of infected host-cells by Trypano-soma cruzi .

Study of malaria parasites
１）Specific immune reaction in malaria.

Stady of Leishmania２）Surviving strategies of Plamodium falciparum

１）Characterization of Leishmania donovani isolates from Nepal.

in mammalian hosts.
３）Epidemiology of human malaria.

２）Establishment of animal models of visceral leishmaniasis.
Other studies
１）Epidemiology of intestinal protozoan infection.
２）Experimental Entamoeba histolytica infection
in rats.
Professor

Hiroji Kanbara

Assistant Professor

Haruki Uemura

Research Associate

Shusuke Nakazawa

Technician

Miki Kinoshita

Technician

Megumi Morisaki

Postgraduate Student

Toshio Miyazaki

Postgraduate Student

Kishor Pandey

Laboratory for culture

Plasmodia sporozoites from ruptured oocysts in
Anopheline mosquito

Amastigotes（left）and trypomastigotes（right）of
Trypanosoma cruzi―１４―

Department of Parasitology
The research activities are concentrated on filariasis, schistosomiasis, and intestinal helminthiasis
which constitute the major public health problems in
the tropics.
Filariasis

Brugia malayi (Cheju strain, periodic form),B.
pahangi and the vector mosquito,Aedes aegypti (Liverpool strain)have been maintained in the laboratory
for many years. Highlights of recent studies are as
follows.
１）Development of a simple and sensitive method for
determination of serum concentration of ivermectin(IVM) and diethylcarbamazine (DEC):IVM and DEC modified partially in their chemical structure successfully produced the antibody
against drugs. Therefore the serum concentration(5ng/ml)of IVM and DEC can be determined by EIA.
２）Screening of antifilarial drugs from medical
plants:Vernonia amygdalina from Africa, Neurolaena
lobata from Guatemala and Cardiospermun halicacabum from Thailand, were effective in vitro on B.
pahangi adult worms and microfilariae.
３）Epidemiology and control of bancroftian filariasis:
A research project was carried in Kwale, Kenya,in cooperation with Kenya Medical Research Institute (KEMRI) during the period of 1990 and 1996.
Transmission potential and morbidity were studied.
Mass-chemotherapy with combination of DEC andNaHCO３ was evalualed.
４）Chemotaxis of filarial infective larvae:
We first reported B pahangi infective larvae
show chemotaxis to serum. The peculiar chemotactic
movement, the signal transudation involved in chemotactic response and serum characteristics that cause
chemotactic response of larvae have been studied.

some strain of vector snails have been maintained in
the laboratory. Highlights of recent studies are as
follows.
１）Swimming behavior of miracidia:
cAMP is involved in the control of ciliary beating and chemotaxis of miracidia, and the vigorous
swimming of miracidia inside the egg-shell is a key
factor for hatching of miracidia.
２）Mechanisms of penetration of cercariae into skin:
The studies suggest the involvement of protein
kinase C in proteolytic enzyme release from cercariae.
３）Epidemiology and control of S. haematobium infection:
Since 1981, the research project on Schistosomiasis haematobia was carried out in Kwale, Kenya,in cooperation with KEMRI for 25 years. The highlights of our studies are human water contact study,
cercarial concentration in natural water, ecology of
Bulinus globosus , usefulness of urinary reagent
strips, new immunodiagnostic test (urine ELISA,
modified COPT) , effect of piped water supply, KAP
study (knowledge, attitude and practices), health education, morbidity studies using ultrasound, environmental modification for snail control, prevalence of
bladder cancer and liver fibrosis, and qualitative andquantitative studies on difficulty of urination in thecommunity.
Intestinal helminthiasis
Since 2000, epidemiologial studies on intestinal
helminthiasis has been taken up. The studies aim toshow that mode of transmission is different in countries and main determinant is human behaviour.
Professor
Research Associate
Research Associate
Technologist
Technician
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student

Schistosimoasis

Schistosoma mansoni (Puerto Rican strain and
Kenyan strain), S. haematobium (Kenyan strain)andExamination of difficulty of urination by using Uroflowmeter in an endemic area of Kenya

Yoshiki Aoki
Kanji Watanabe
Yoshinori Mitsui
Mitsumasa Miura
Satomi Tominaga
Tomoharu Ohki
Teruyo Kusaba
Mayumi Abe
Xinsong Zhang

Examination of contamination of soil by eggs and larvaeof intestinal helminth in Vietnam―１５―Department ofThermal Adaptation
The department was established in１
９９
４to study on
the influence and damage of tropical environment on
human and animals. Then study result is applied inprotection and care of tropical disease for improving
infection and symptom.
Study on short and long term heat acclimatization of humanOn the short term heat acclimatization, it experiment to expose Japanese to heat in environmental
chamber for period from spring to summer. They
sweat too mach and high electrolyte concentration in
the sweat for surplus reaction, so they have big damage as compensation of body temperature control.
Heat loss responses of Tropical inhabitants arestudied in the short term heat acclimatization. Their
nonevaporative heat loss by blood circulation are effective, and their sweat is a little with low electrolyte concentration as comparison with Japanese it.
Therefore, they sweat minimum volume, and haveheat tolerance(Left figure).
Victims by heat stroke decrease, who are mainly
children and old men. Society and economy develop
by ability adaptation for heat acquired, which increases working ability without discomfort and fatigue.
A study of effective defense method from ultraviolet
rays
Ultraviolet rays (UV) contained by Sun lightcause various damage in the living body, and UV is alarge quantity and strong power in the Tropical Zone
and the mountains in particularly. Therefore,thecreatures on earth acquired various defense methods
for ultraviolet rays harmful to body in a process ofevolution.
We have been promoting the study of defense
methods from ultraviolet rays in wild animals which
inhabit in a low latitude area, the desert and mountains (Right figure: black layer of body hair absorbs
UV) in particular.
For the purpose, we study effective defense
mechanisms for ultraviolet rays in wild animals, thenwe design the best defense method against ultraviolet
rays with nature and harmless.
The influence of change in biophylaxis functions induced by ultraviolet radiation to infection of tropical disease
Skin cancer occurs by strong ultraviolet radiation for a long term. The exposure to more little
mount of ultraviolet rays may be influence biophylaxis function to infection. UV in the Tropical Zone
are strong, and many persons suffer from infectious
disease. There are approximately 250 million patients with schistosomiasis in Tropical Zone.
In our experiment on infection of Schistosoma
mansoni cercariae to mouse, ultraviolet radiationgroup by ultraviolet lamp (UV-B) was statistical difference in the number of Schistosoma mansoni cercariae invaded into skin and recovery the adult
warms compared with nonirradiation group. We experiment the influence of ultraviolet rays in Sun
light on it now.
This study elucidates influence of ultraviolet
rays for infectious disease and contributes to the infectious disease control, in particular,in the Tropical
Zone with strong ultraviolet rays.
Associate professor (Additional post)
Nobu Ohwatari

Experiment of thermal sweating in the environmental
chamber―１
６―

Pika inhabiting the mountains of 3200!

strictly required TRTGNB (R=purine, N=any base,

Department of Host-Defense Biochemistry

B=not adenine, G paired with T) and 14-mer or
longer for binding. G can be replaced by deaminatedReserches in our laboratory are focused on theA, namely, hypoxanthine, suggesting deaminated C-6

molecular regulations of the phagocyte NADPH oxi-

is essential for nGTBP binding. Deamination of nu-

dase system that generates active oxygens essential

cleotide bases are increased by high temperature andfor killing invading microbes.

the repair of deaminated portions of DNA would be
more important in tropical area than other areas.

Selective expression mechaisms for gp 91phox, a core com-

Transitions appreciably occured more at TRTRNB

ponent of the oxidase

sites than at other sites in tumor supressor protein p

The phagocyte NADPH oxidase is composed of

53 exons, suggesting this particular sites were frag-membrane-integrated flavocytochrome b 558 contain-

ile in tumor-prone cells.

ing gp 91phox and p 22phox, and cytosolic components

esophageal cancer due to transitions at p 53 non-GpG

phox

phox

Relative frequency of. Upon phagocytotic stimu-

sites in Brazilian mate-drinkers was relatively

lation, cytosolic factors move to membrane to makehigher than that in world-wide patients. Cloning andan active complex with the flavocytochrome. Basedpurification of this nGTBP are now urgent issues inon genetic analysis of CYBB , the gene encoding gp

our laboraatory.

such as p 47

and p 67

91phox, in a patient with chronic granulomatous disease, we found that PU.1, a transcriptional activator,

Professor

Michiko Nakamura

bound to gp 91phox promoter position centered to bp -Assistant Professor

Futoshi Kuribayashi

inResearch Associate

Yoshito Fujii

neutrophils, monocytes, and B lymphocytes, but not

Research Assosiate

Shoichi Suzukiphox

53 was important for the expression of gp 91（…in suspension）

in eosinophils. On the other hand, GATA-1 bound toa position centered to bp -98 had an important role in
the expression of the gene in eosinophils. We are
now interested in the mechanism that can modulate
the expression of CYBB in selected types of cells
for improving primary defense system in inflammation and allergy.

A novel GT-mismatch binidng protein
In the analysis of a cis -element of gp 91phox promoter,we found a novel GT-mismatched DNA binding
protein. An addition of unlabelled competitor homoduplex with G/C at bp -177, generated, but noterased, a strong 'supershifted' band in EMSA using
the labelled probe with A/T at bp -177.

Newlypaired heteroduplex with the unlabelled upper standwith G at bp -177 and the labelled lower stand with T
at the same position recruited nGTBP. This protein―１
７―Technical assistantKanae Tanaka

Department of Pathology /Division of Clinical Investigation

Virus infections of the central nervous system.
Flavivirus encephalitis, such as Japanese encephalitis and tick-borne encephalitis, and rabies are

In１
９
７０，
the Late Professor Toyosuke WATAN-

still big problems in the southeast and east Asia . Re-

ABE classified tropical diseases into４groups:

cently, enterovirus ７１ infection among children is

１．Diseases caused by pathogens, uniquely present

frequently associated with serious neurologicalmanifestaions in these areas. We are investigatingin the tropical areas.
２．Diseases induced by environmental factors suchthe clinicopathological aspect of these infections andalso performing animal experiments to establish

as tropic climate.
３．Diseases specific for some habitants in thetropical areas due to their high susceptibility.
４．Diseases difficult to prevent in developing coun-

their pathogenesis and prevention.
Carcinogenesis in papillomavirus infection.
Neoplasms, dysplasia and condylomas of the mu-tries.
Now, we are investigating the pathogenesis ofcosa and skin are investigating for the presence oftropical diseases based on this concept and aim to es-

papillomaviruses using the molecular and pathologi-

tablish the fundamental basis of their prevention andcal methods. In addition, we are developing an animaltreatment.

model of mucosal carcinogenesis using hamster.

Activities

Virus infections of the respiratory tract.
Human cases with airborne-infections such as

Pathological diagnosis of infectious diseases.
We are developing various antibodies and molecular probes available for diagnosis of infectious
diseases on the clinical specimens obtained at cytology, biopsy, necropsy and autopsy. We are also per-influenza and measles are studied for pathological diagnosis and their pathogeneses.
Pathology of tropical diseases.

forming various animal experiments to obtain posi-

Epidemiological and histopathological studies

tive controls for this analysis and to analyze theirare being done in the southeast Asia for tropical dis-pathogeneses.

eases and its sequelae.

Professor

IWASAKI, Takuya

Associate Professor TORIYAMA, Kan

Legend: The central nervous tissue of a cynomolgus monkey inoculated with enterovirus７１(EV７１）． Left: Hematoxylin−eosin stain.
Right: Immunostaining for EV７
１capsid antigens.

―１
８―

Research Associate

SENBA, Masachika

Research Associate

HAYASAKA, Daisuke

Research Associate

AGO, Masanobu

Technician

NAKAMURA, Masako

Department of Internal Medicine
Main objectives of research activities in the Department of Internal Medicine are to understandpathogenesis of tropical diseases and respiratory infectious diseases and to improve diagnosis, prevention and therapy for infections diseases in developing
countries. Various basic scientific research and international collaborative studies are on going as follows:
1.Respiratory Infections
Our goal is to better-understand mechanisms
causing severe and treatment-refractory pneumonias
at molecular levels toward development of a novel
treatment strategy. We hypothesize that patientswith severe and treatment-refractory pneumonia has
an impaired process in inducing the cessation of inflammation and re-construction of damaged tissues.
We, particularly, focus on the function of macrophage which is responsible for clearing apoptotic
cells from the inflammation site using a mouse pneumonia model. We also conduct studies on biofilm formation and molecular epidemiology of pneumococcus,
hemophilus influenza etc.

been established in Lampang Hospital, northern
Thailand. We are planning to facilitate host-gene
polymorphisms, molecular immunology, molecularepidemiology and virology studies for a better understanding of HIV transmission and HIV pathogenesis.
4.Studies of Dengue Disease in the Philippines
In collaboration with St. Lukes Medical Centerand San Lazaro Hospital in Metro-Manila, the Philippines, we have been studying pathogenesis andclinical and epidemiology aspects of dengue diseases.
Our focus has been on mechanisms of thrombocytopenia, which is a characteristic feature of dengue
virus infection.
5.Pneumococcal vaccine study for HIV-infected individuals in Uganda
As a collaborative study with the Joint ClinicalResearch Center in Kampala, Uganda, we have been
evaluating the induction of specific antibody and opsonic activity in HIV-infected individuals after immunizing those with a 23-valent pneumococcal polysaccharide vaccine.

2.Pediatric Infectious Diseases in Vietnam
We have, so far, conducted studies on clinicaland bacteriological diagnosis, antimicrobial susceptibility and molecular epidemiology in collaboration
with National Institute of Hygiene and Epidemiology.
Since 2005, we further collaborated with International Vaccine Institute and started a large-scale ofcensus survey targeting all residents in Nha Trangcity and its adjacent Nin Hoa district in the middle
part of Vietnam. During the census, we also collectinformation regarding environment and diseases burden (particularly pneumona, diarrhea, dengue fever),health care utilization pattern.
3.HIV cohort studies in northern Thailand
In collaboration with National Institute of
Health, Thailand and National Institute of Infectious
diseases, Japan, a large scale of cohort study targeting HIV-infected individuals and their spouses has

San Lazaro Hospital (Manila)

Professor
Koya Ariyoshi
Associate Professor
Konosuke Morimoto
Research Associate
Kei Miyagi
Research Associate
Kiwao Watanabe
COE Research Associate Hiroshi Nakaoka
COE Researcher
Mariko Saito
COE Researcher
Sei Nishimura
Technician
Naoko Kirajima
Technician
Miki Magome
Secretary
Rika Nogawa
Postgraduate student Jun Koyama
Postgraduate student Takayuki Oike
Postgraduate student Toshitaka Sukizaki
Postgraduate student Yoshiyasu Yoza
Postgraduate student Chen Meng
Postgraduate student Vu Thi Thu Huong
Postgraduate student Chiharu Kaji
Postgraduate student Hiroaki Yoshii
Postgraduate student Nanae Taguchi
Postgraduate student Takeshi Yamamoto
Assistant Professor Toru Matsubayashi (CICR)
Research Associate LayMyint Yoshida (CICR)

Laboratory of molecular chemistry―１
９―

showing that actin-dependent clustering of the recep-

Department of Preventive
Medicine and AIDS Researchtors is involved in the retrovirus infection. The receptors, however, do not directly associate with actin.
We try to identify the cellular molecule that func-

This department was newly added to the insti-

tions as a linker between the receptor and actin.

tute in １
９７
８ as a research division open to visiting
professors from other universities and institutes. It

Application of HIV envelope gene to gene therapy

is run by concurrent research staff for the present.

HIV enters into target cells by fusion between

We have planned and started from August of ２００
２avirus envelope and cell membrane. This reaction isseries of fundamental research to answer the ques-catalyzed by envelope glycoprotein encoded by thetion how and what mechanisms human immunodefi-

viral genome. When the envelope gene is introduced

ciency virus and murine leukemia virus enter into

to susceptible cells expressing CD４and CXCR４，

host cells. In addition, we are studying the applica-

syncytium formation is induced by its membrane fu-tion of these retrovirus to human gene therapy.

sion activity, and die. Recently, CD４-independent
HIV has been isolated. When the envelope gene of theStudy on the mechamism of viral entry into host cells by

CD４-independent HIV is introduced to cells ex-

retrovirusespressing CXCR４but not CD４，syncytium and cell

Human immunodeficiency virus (HIV) is known

death was induced. It has been reported that CXCR

to be a causative agent for acquired immunodefi-

４is up-regulated in mammary tumor. This suggests

ciency syndrome. After the HIV recognizes CD４andthat the CD４-independent HIV envelope protein

chemokine receptor, for example CXCR４，
it enters

specifically induces cell death of mammary tumor

into target cells mediated fusion between virus enve-cells. We are studying the application of the CD４-

lope and cell membrane. Murine leukemia virus

independent HIV envelope as a novel therapeutic(MLV) recognizes CAT１as the infection receptor,

gene for mammary tumor.

and enters into host cells by same manner. It is most
likely that the environment around the receptors in-Visiting Professor

Naoki Yamamoto

fluences the infection efficiency. In this context, weVisiting Associate Professor Hironori Satoare studying the effect of receptor glycosylation andAssistant Professor

Yoshinao Kubo

lipid factors proximal to the receptor on the HIV andTechnician

Chika Tominaga

MLV infection.
On the other hand, there are some evidences

Laboratory for biochemical researchLaboratory for biochemical research―２０―experiment are performed to establish more realistic

Department of
Vector Ecology & Environment

larval indices. In the laboratory Aedes aegypti andAe. albopictus are studied on their ecological characters among geographical strains. Feeding behavior

Main interest of the department is analysis ofenvironmental factors that affect the trasmission of
insect-borne diseases, and pursuing environmental

and population dynamics of these mosquitoes also arestudied in the laboratory and fields.
３．Vector control technique related studies

friendly vector control strategy.

Basic study of copepods as a hopeful biological

１．Physiology and ecology of malaria vectors

control agent against vector mosquito larvae. Bio-

A long-term monitoring on main vectors of malaria has been conducted at several fields in South-

chemical approach to insecticide registance in vector
mosquitoes.

east Asian countries. Spatial and temporal changes
in larval habitats, vegetation, and the impact of hu-

Professor

Masahiro Takagi

man activity on the environment are evaluated in re-Assistant Professor

Hitoshi Kawada

lation to abundance of vectors, host preference, andResearch Associate

Nobuko Tuno

other population parameters. The GIS/RS is intro-

COE Researcher

Kazunori Ohashi

duced as a new tool to analyze the environment. Geo-

Secretary

Toshiko Uenographical strains of several Anopheles are compara-

Technician

Chiaki Tsurukawa

tively studied by morphological, physiological, andSecretary

Junko Sakemoto

genetic approach.

Postgraduate Student

Maiko Hasegawa

２．Ecology and control of dengue vectors

Postgraduate Student

Tran Vu Phong

Epidemiological studies have been conducted at

Postgraduate Student

Yoshihide Maekawa

several fields in Southeast Asian countries. Monitor-

Postgraduate Student

Masaaki Sugiura

ing by oviposition traps and mark-release-recapture

Postgraduate Student

Ataru Tsuzuki

Stereomicroscopic observation of mosquitoes

Ramp traps for collecting mosquitoes―２１―Department ofSocial Environment
Specific Features of the Department
This Department covers under the 10th tenureinterdisciplinary field of Environmental and Social
Medicine related to health services and social welfare problems in developing countries.
Interdisciplinary approach includes studies in
Social Sciences and Humanities. Further, methods
and actual means of international cooperation toward
developing countries has been sought to utilize in order to promote inter-departmental linkage for information accumulated with specific analysis and professional response to the public, particularly in thefield of infectious diseases diagnosis and control.
Under this context, basic and applied research
have been carried out in the following prospective
themes from the view point of environmental and social aspects for the purpose of promoting assistanceto minimize health problems in tropical areas:
Area of Research Activities:
１．Study and analysis on social (incl. life style, political and economical) background which regulates
frequency / areas / accumulation of diseases of thepresence of epidemics.
２．Study on the effect of individual and social environment toward endemic and epidemics.
３．Standardization of human security measures in
the field of health services from the view points ofnutrition and 3 Es ie.economy, environment andeducation.
４．Study on control of communicable diseases
among the regional and international health careprograms.
５．Study on quantitative and qualitative values of
medical and health services under the ODA ie. Official Development Assistance programs by Japanese government.
６．Feasibility study on comprehensive information
filing and network system for the sake of promoting health and social welfare services in developing countries, by epidemics, by regions, by administrative measures.

The Dept. often organizes Int'l Symposia.

７．Reformation and coordination of health manpower traning program / system to meet the needof tropical area in connection with Risk Management.
８．Comparative studies on the control of emerging
infectious diseases in tropical Asia such as West
Nile and SARS or Avian Flu.
Specific themes of joint cooperative research
designated to the Department in FY 2006 under thescheme of Research Institute for Nationally JointUse are listed below. The Technical and Management Committee recommended that interdisciplinary
research collaboration should be realized from theviewpoint of middle and long-term range and managed
not only by single department but also by the whole
Institute as one of the important mandates.
Joint Research projects themes:a)Control and prevention measures for the Millennium Development Goals (MDGs) from the view
point of tropical medicine and international health.
b)Analysis of socio-environmental factors of the control and prevention of infectious diseases.
Noted results of research projects have often
been integrated and fully utilized in the forms of
seminar or symposium for covering valuable themes.
Research Forum theme:
Feasibility of technical cooperation for control
of infections based on the understanding of socioenvironmental changes.
Professor
Research Associate
Research Associate
Research AssistantTechnician
Visiting Researcher
Postgraduate Student
Postgraduate Student
Postgraduate Student
JICA Trainee
JICA Trainee

Tsutomu Mizota
Susumu Tanimura
Kensuke Goto
Tomomi Ikeda
Natsuko Imaoka
Chizuko Suzuki
Qin Liang
Takeshi Yoda
Kazuo Minematsu
Olga Maria Amiel
Lamine Bangoura

Joint Cooperative Research Members join in the meetingfor preparing textbook.

―２
２―

２）
Genetic analysis of Trypanosomes in Latia
Americas by using local isolates and molecularbiology.

Department of
Immunogenetics
This department is focusing on the pathogenic
genetic factors of the host and the parasite in themost important tropical infectious diseases by using
immunology and genetics.
Research activities:
To clarify the molecular mechanisms in the protective and/ or pathogenic host response to humanpathogens such as Dengue Virus, TB, Malaria, Trypanosoma cruzi, Schistosoma, and Filaria, the following research projects are going on in our laboratory.
１．
Malaria１）
Genetic susceptibility to severe forms of malaria (cerebral malaria, severe anemia) is analyzed by case-control study in South East Asia,
South Pacific and West Africa.
２）
Malaria vaccine development using the immunological characteristics of resistant persons
living in the endemic area in Asia and West Africa.
２．
Schistosomiasis
１）
Immunological regulation of the pathogenic anti
egg response in the resistant and susceptible
persons, to post-schistosomal liver fibrosis in
China and Philippines.
２）
Miniature pig schistosomiasis as a humanmodel.
３）
Vaccine development for schitosomiasis japonica and masoria using schistosomula antigens.
４）
Production of the new diagnostic Kit for active
infection.
３．
Chagas disease１）
Genetic susceptibility to different clinicaltypes of chronia Chagas disease, namely, indeterminate, cardiac, and digestive forms, is analyzed by case control study in Bolivia where
Chagas disease is still highly endemic.

Collaborations:
The research here is performed based on thewell arranged collaborative projects with the following facilities.
１．
Malaria: Tharmmasat University (Thailand),
Noguchi Memorial Medical Research Institute(Ghana), Institute of Medical Research (Malaysia),
Karolinska Institute (Sweden), Ehime University(Matsuyama), WHO/ TDR (Geneva Switzerland)
２．
Schistosmiasis: Jiangxi Provincial Institute ofParasitic Diseases (China), Jiangsu Provincial Institute of Parasitic Disease (China), Univ. Philippines and RITM (Manila, Philippines), Tokyo
Medical Dental Univ. (Tokyo)
３．
Chagas Disease: Center of Tropical Medicine andHospital Japones (Bolivia), IICS University of
Asuncion (Paraguay)
４. Dengu virus
１) Pathogenesis of the DHF (Dengue Hemorragic
Fever)
Host factors will be detected by the Populational genetic analysis of the patients with DHF
and non DHF.
StaffsProfessor
Professor (Project)
Associate Professor
Lecturer (Project)
COE Researcher
COE Researcher
Technician
Ph. D. Student
Ph. D. Student
Ph. D. Student
Ph. D. Student
Ph. D. Student
MSc Student
MTM Student

Department of Molecular Immunogenetics

Kenji Hirayama
Michio Yasunami
Nobu Ohwatari
Mihoko Kikuchi
Kazunari Ishii
Naoko Okuda
Junko Hayashima
Dujdow Songthamwat
Akiko Takaki

Ekhlas hamed Abdel Hafeez Abdow
Nguyen Thi Phuong Lan
Akiko Yamazaki
Del Puerto rodas Ramona Florencia
Fernando Gerald Vera Gamez

Clean Room for Cell Cuture―２
３―

Clinic at the University Hospital
The Department of Internal Medicine is the only
one clinical department at the Institute of Tropical
Medicine. It has a clinic and a medical ward with
about 20 beds on the 12th floor of the Nagasaki University Hospital. We specialized in the Infectious
Diseases and Chest Medicine; diseases that we handle are systemic infectious diseases, including tropical diseases and HIV infection, and pneumonia including tuberculosis, and various neoplasmic and inflammatory respiratory diseases. We actively receive consultations regarding diagnosis and management of infectious diseases from other departments.
The outpatient clinic is open two days a week where
we started a travel clinic since April 2004. We arealso involved in various clinical trials such as cancer
treatment, antibiotics, GM-CSF therapy for pulmonary alveolar proteinosis. We have also responsibilities for training medical students (lectures and bedside teaching) and for postgraduate training programs for general internal physicians and infectious
disease and chest medicine specialists. Since April
2006, we have been organizing a clinical case conference (in English) for tropical diseases as a part ofMaster of Tropical Medicine course.
Professor
Associate Professor
Assistant Professor
Research Associate
Research Associate
Research Fellow
Research Fellow
Research Fellow
Research Fellow
InternResearch Associate

Animal Research Center
for Tropical Infections
The center makes it the principal aim to ensure
the safety of animal experiments which deal with thepathogenic microorganisms and to build up the successful generation of experimental animals, microorganisms and parasites. The building consists of 7
breeding rooms for experimental animals, 2 laboratories, one breeding room for snails and insects, and
two P 3-level biohazard laboratories. The air pressure is kept to be always negative to avoid outflow
from inside even at entrance to building. Since thebuilding has the most thorough ventilation through
HEPA filter, any microbe cannot leak out to outsideof the building. The used water is given chlorinationand drained off. The breeding animals and experiments are done according to the Guideline for Animal
Experiment edited by Nagasaki University. The
laboratory animals bred in the center are mice, rats,
hamsters, gerbils, rabbits, snails and mosquitoes.
Professor and Director
Research Associate
Technician

Michio Nakamura
Tetsuo Yanagi
Junko Kawashima

Koya Ariyoshi
Konosuke Morimoto
Hiroshi Watanabe
Yoshiko Tsuchihashi
Reiki Kuroki
Mayumi Terada
Takeshi Tanaka
Reiko Mizutani
Naho Tsuchiya
Yoko Tsumori
Shoko Honda

Mongolian gerbil （ Meriones unguicalatus ）Clinical conference―２
４―Research Center for Tropical
Infectious Diseases（RECTID）
Research Center for Tropical Infectious Diseases, RECTID, was established in April 2001, as
one of the outcomes of the Japanese government's
commitment for promoting global parasitic disease
control, on the basis of the Reference Center (since1974) and Information and Reference Center (since1997) of the Institute of Tropical Medicine. The
founding head, Professor Masaaki Shimada is now
the head of Nairobi Research Station for NUITMKEMRI project in Kenya. RECTID has the following
four fields of activities; 1) developing the museum of
tropical medicine, 2) collecting and disseminating information on tropical infectious disease researches,3) promoting joint research projects, and 4) conducting eco-epidemiological field studies as well as theoretical epidemiological studies.
First, RECTID is responsible for running an
exhibition/audio-visual room. Our current exhibitions consist of panels of major tropical diseases
such as malaria, diarrhea diseases, ARI, AIDS, TB,
filaria, schistosomiasis, and specimen of parasites,
vector arthropods and poisonous marine animals, etc.
Pathological tissue specimens are also collected.
References currently available are historical books,
periodicals and documents, films, video/DCD/DVDs,
photo slides, and photographs. The exhibition roomhas moved to the first floor in 2006, and many researchers and students are now visiting the exhibition room. In the near future we would like to expand
the exhibition room to the museum of tropical medicine. The museum will enhance the unique function ofrisk communication for outbreak of tropical infectious diseases.
Second, RECTID gathers and analyzes biological, medical, socio-economic, and cultural information related to tropical diseases and disseminates information on researches on tropical medicine mainly
through internet to all the staff researchers, graduate students and trainees, as well as members of the
public at large. Materials in the exhibition room are
now being digitized and are available through cyberspace. Professor Masahiro Horio is the curator of
the exhibition room and also developing the RECTID
website with other staff.
The third and forth missions of RECTID is tocontribute to the global control of the tropical infectious diseases by promoting and conducting re-searches. We analyze the factors that regulate theepidemics of the diseases to find appropriate control
measure of the infection. RECTID organizes andcarries out the integrated eco-epidemiological fieldstudies on tropical diseases in Africa and Asia. We
are trying to see the natural history and epidemiology of tropical infectious diseases in endemic areas
by means of the combination of long-term field observation by using demographic surveillance system andtheoretical epidemiology of infectious diseases. Oneof our main interests is the role of human behavior in
the transmission of tropical infectious diseases. We
would like to see the human ecological impacts oftropical infectious diseases both in the local andglobal perspectives.
Professor and head
Professor
Professor/ Curator
Research Professor
Research Professor
Research Professor
Research Professor
Research Professor
Visiting Professor
Visiting Professor
Assistant Professor
Assistant Professor
Assistant Professor
Research Associate
Research Associate
Researcher Fellow
Researcher Fellow
Researcher Fellow
Research Student
COE Researcher
Research AssistantResearch AssistantTechnician
TechnisianTechnisianTechnisian
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student

Kazuhiko Moji
Masaaki Shimada
Masahiro Horio
Noboru Minakawa
Satoshi Kaneko
Yoshio Ichinose
Hideki Yanai
Yasuhiko Kamiya
Nick Mascie-Taylor(Cambridge Univ)
Pathom Sawanpanyalert(Thai NIH)
Sumihisa Honda
Hiroshi Nishiura
Akiko Matsuyama
Eiko Kaneda
Toshihiko Sunahara
Kyoko Futami
Kouhei Takenaka
Masahiro Hashizume
Nobuyuki Nishikiori
Shouhei Takeuchi
Kyoko Sakitani
Kazuo Araki
Kiyomi Suda
Youji Shimizu
Akiko Komazawa
Shin Ryou
Yuko Nakao
Guoxi Cai
Tomoko Abe
Rieko Nakao
Magafu Mgaywa Damas
Osuke Komazawa
Ayumi Nomura
Etuko Hatagishi

New Evidence for Medicine and Public Health in Africa

OthersMonitoring of
morbidities andmortalities

Interventional Studies
and Evaluation

Observational
Hypothesis-oriented
Studies

Collaboration

Generation of
Hypothesis forlong-term
studieslong-term studies designed based on evidence

Laboratory

GIS

Biostatistics

Demographic
Surveillance
System（DSS）

Short-term
studies

Network and IT
support

Education andTraining

GRAND DESIGN OF THE NUITM-KEMRI PROJECT―２
５―

Exhibition Room of Tropical Medicine

Central Laboratory
There are equipments shared in the institute.
Those equipments are maintained and operated by
the staffs listed below. There are three major laboratories to be set up, namely electron microscope lab,
P 3 and cell culture lab and molecular biology lab.
Electron microscopies (TEM and SEM of jeol), a Ultramicrotome (Reichert), con-focal laser microscope
system (LEICA DMIREZ), a flow cytometer (Becton), Bioimage analizers (Hamamatsu Photonics, Bio
rad GS-250 and Pharmacia Image master), DNA sequancers (Perkin-Elmer), a DNA/RNA extraction
system (Qiagen), two P 3 rooms, and 2 dimensional
protein purification system (Beckman). Following are
the major equipments.

Professor

Kenji Hirayama

Assistant Professor

Akitoyo Ichinose

Technician

Hitomi Horie

Lab for Genetic Analysis―２６―

２．Dispatch of Japanese researchers
Four professors, one is a program leader, and one
administrative staff member work in the Nairobi Station.
They are to be provided with special logistic support by
one professor and one associate professor of ITM.

Infectious Diseases Research Program
Nairobi Research Station, Kenya(A Special Grant from the Ministry of
Education, Sports, Culture, Scienceand Technology, 2005〜2009)
Outline of the program
The Institute of Tropical Medicine (ITM) has received a government grant for the promotion of researchon tropical diseases and emerging and reemerging infectious diseases. With this special, ample grant of money,
ITM established a research station in Nairobi, Kenya.
The unique feature of the Nairobi Station's research program is long-term, extensive, and multidisciplinary studies based on the Japan-Kenya collaboration. The program provides training for young researchers both Japanese and Kenyan, and in collaboration with JICA, contributes to the disease control and health promotion in thetropics with the fruits of its research.
Progress of the program
１．Research station in Kenya
The Research station was set up in the Kenya Medical Research Institute (KEMRI), Nairobi. KEMRI is oneof the overseas research organizations with which ITM
has long been doing a cooperative research. Based on
the academic agreement between Nagasaki University
and KEMRI, the signing ceremony for the new research
program's Memorandum of Understanding was held on
September 13, 2005. The Research Station is now partially equipped to facilitate bio-medical and epidemiological studies in tropical diseases. In the very near future, the P3 laboratory and Demographic Surveillance
System will be completed.

３．Study areas for the long-term and extensive researchwork
The Demographic Surveillance System (DSS) will
be put into operation in two regions, the Suba area in
Western Kenya and the Kwale area on the Coast. The research proposal of DSS has been approved by the scientific and ethical committee of KEMRI and ITM.
４．Studies in infectious tropical diseases
Research projects on schistosomiasis and malaria
were launched. The projects include studies in epidemiology of schistosomiasis, hidden morbidity of schistosomiasis haemtobia, and malaria vector control in Kenya.
５．Training program
Under the patronage of JICA, four Kenyan researchers and doctors were given a chance to visit ITM andwere trained in research on tropical medicine. Professorsof ITM served as advisers in the JICA-sponsored International Parasite Control which took place in Kenya.
Program Staff
Program Leader and Professor Masaaki Shimada (Nairobi Station)
Professor Yasuo Ichinose (Nairobi Station)
Professor Noboru Minakawa (Nairobi Station)
Professor Satoshi Kaneko (Nairobi Station)
Professor Masahiro Horio (Institute of Tropical Medicine)
Associate Professor Hiroshi Nishiura (Institute ofTropical Medicine)
Administrative Staff Shiho Honda (Nairobi Station)
Post-doctorate Fellow Kyoko Futami (Nairobi Station)

Signing ceremony on September 13, 2005

Nairobi Research Station, Nairobi, Kenya―２７―also provide guidance for ethical consideration and deter-

Research Center: Clinical Epidemiology of Emerging and Reemerging Infectious Diseases Laboratory
in Hanoi, Viet Nam (A special research program of
the Japanese Government for the establishment of a
research center for emerging and reemerging infectious diseases, 2005〜2009)mining of perfect strategies to counter any potential infectious disease outbreak.
Meanwhile, the research work in Viet Nam willconcentrate on the following areas:
１）zoonotic infectious diseases including avian influenza, hanta, nipah virus infection, and rabies;２）vectorborne infectious diseases, including malaria
and dengue virus infection;３）fecal-oral infection including rotavirus, norovirus

Outline of the program

infection, and cholera;

In 2005, the Government of Japan (Ministry of Education, Culture, Sports, Science and Technology) pro-４）human to human infection, including acute respiratory infections.

vided special funds to certain grant-winning Japanese
universities for the purpose of establishing research centers for emerging and reemerging infectious diseases inorder to make joint studies with overseas research institutions. Nagasaki University, one of the recipients, set up
Research Centers in Nagasaki and Hanoi, Viet Nam to
study clinical epidemiology of emerging and reemerging
infectious diseases, including disease ecology, intervention, and protection and prevention, thereby contributing
to the control and/or elimination of infectious diseases,
which is today's global concern.
The Research Centers have been managed in collaboration with four institutions, the Institute of TropicalUpdate status
The project document has been approved by the Vietnamese Government, and the Friendship Laboratory
has been equipped with apparatus for bio-medical andepidemiological studies on infectious diseases.
The Center had its opening ceremony on March 17,
2006 in Hanoi, and started epidemiological study on
avian influenza and dengue fever infection while developing the Demographic Surveillance System for longbased and extensive infectious diseases studies.
NIHE-Nagasaki University Friendship Laboratory Staff

Medicine (ITM) of Nagasaki University, the Interna-

Project Leader and Professor

Koichi Morita

tional Medical Center of Japan, Tokyo, the National In-

Professor

Tetsu Yamashiro

stitute of Hygiene and Epidemiology (NIHE), Hanoi, andProfessor

Futoshi Hasebe

Bach Mai Hospital, Hanoi, with ITM and NIHE playing

Professor

Hideki Yanai

a major role in the operation.

NIHE has the NIHE-

Research Fellow

Yukiko Higa

Nagasaki University Friendship Laboratory in which

Research Fellow

Motoi Suzuki

Japanese researchers are now carrying out infectious dis-

Administrative Staff

Yoshio Furuya

eases research. In Nagasaki, the research projects focus

Post Doctoral Fellow

Gen-ichiro Uechi

on basic strategic research and product development, andNational Institute of Hygiene and Epidemiology (NIHE)

Opening ceremony of the Research Center in NIHE

―２
８―

achieved not solely in Fiji but by the regional laboratory

Japanese support to the Pacific Immunization Program Strengthening (J-PIPS)
Suva, Fijiof the South Pacific countries, as well.
J-PIPS holds regular “regional trainings” in Suva for
immunization project leaders, as well as supplementary
health workers “country trainings” in each target country

The Japanese support to the Pacific Immunization
Program Strengthening (J-PIPS) is a 5-year project ofwith the active participation and in collaboration with theFiji Ministry of Health, WHO and UNICEF.

JICA in 13 South Pacific island countries. The project
Annual surveys are conducted by J-PIPS in the 13

aims to strengthen capacity development in the Pacific in
the area of immunization services through resource development of EPI management staff and to upgrade thequality of EPI services provided. The Center for International Collaborative Research (CICORN), Nagasaki University, is responsible for the administrative management

South Pacific island countries, in order to assess, determine and discuss with counterparts updates on occurrence of target communicable diseases and other projectissues. Survey results are gathered and published as annual reports.

of J-PIPS. J-PIPS started operation in February 2005 un-

J-PIPS maintains close communication and collabo-

der the leadership of Dr. Kouichi Morita as Chief Advi-ration with its international agency partners such assor, and who is Professor, Department of Virology, Insti-

WHO, UNICEF, AusAID, NZAID, SPC and other inter-tute of Tropical Medicine (ITM). In March 2005, four

national agencies to ensure a sustained maximum degree

other professionals from CICORN and ITM were as-of effectivity in technical cooperation.

signed to the project office in Suva, Fiji.

Significantly, the J-PIPS project serves as an avenue

The project's two main objectives are: to strengthen

for communicable disease control activities, particularly

the Pacific island countries' EPI program planning andvaccine-preventable diseases, in the Pacific island coun-monitoring system of vaccine-preventable diseases, suchtries and, thus, is in conformity with the ITM mission toas poliomyelitis, measles, Hepatitis B and influenzae ba-“spearhead research in international health” and make acillus; and to establish a functioning regional training“global contribution through health promotion by apply-

system for vaccine logistics, cold chain maintenance, in-ing the results of research”; and is one of the “capacity

jection safety and EPI waste disposal management.

strengthening” projects of CICORN and ITM.

As part of its capacity enhancement program, J-

Project Staff

PIPS in cooperation with the Nagasaki University, coor-

Dr. Kouichi Morita, Professor, ITM

dinates a technology transfer program to assist the target

Dr. Yasuhiko Kamiya, Professor, CICORN/ITM

countries. In March 2006 a Measles outbreak occurred in

Mr. Tatsuhiko Tsukakoshi, CICORN

Fiji where J-PIPS actively participated in its containment

Mr. Kenzo Sasagawa, CICORN

by providing technical support and conducting supple-

Mr. Hiroshi Osawa, CICORN

mentary immunization activity (SIA) campaigns in cooperation with the Government and international agencies.
A staff from the Fiji Centre for Communicable Disease
Control, the regional laboratory for communicable disease and center for diagnosis of virus diseases in theSouth Pacific, and an earlier recipient of the study program from ITM, was remarkably involved in laboratory
diagnosis work during the outbreak containment activities having received capacity enhancement from thescheme. Thus, the benefit of technology transfer was―２
９―First PIPS Regional Training (12-15 December, 2005)

Administration
Tomoko Takenouchi, Assistant Staff

Katsuhisa Jinno, Head Official

Mariko Hirano, Assistant Staff
Etsuyo Uchida, Assistant Staff

General Affairs Unit
Tsukasa Harada, Chief

Mamiko Akagi, Assistant Staff

Naomiki Yamamura, Sub-Chief

Kumiko Shimizu, Assistant Staff

Ami Noda, Staff
Collaboration Research Unit

You Kanai, Staff
Shiho Honda, Staff

Hidemitsu Noguchi, Chief

Junko Suenaga, Assistant Staff

Fumiko Hashiguchi, Sub-Chief

Asuka Mtsuo, Assistant Staff

Yumiko Matsumoto, Assistant Staff

Number of Staff
Divisions

Professor

Enrollment

12(4)(as of May, 2006)

Assistant
Professor
6(1)

Lecturer

Assistant

Sub total

Others

Total

3

17
(1)

38
(6)

8
(2)

46
(8)

※( ) number of fixed-term staff

Accounting
Revenue (in 2005)

Expedditure (in 2005)

Divisions

Amount(in thousands)

Divisions

Amount(in thousands)

Tuition and Matriculation Fee

1,974

Personnel expenses

514,068

Others2,077

the cost of equipment

485,113

Industry-Academic Cooperation

76,855

Total

999,181Donation

16,502

Total

97,408―３０―Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology(in 2006)

Classification

Scientific Research on Priority Areas

Scientific
Research"

Scientific
Research"

Scientific
Research#

Scientific
Research$

Exploratory Research

Young
Scientists
#

Total

Number of Grants

0

1

1

4

1

5

1

13

18,33026,39018,400

1,800

7,600

800

73,320

Amount(in thousands)

0

External Funding(in 2005)

Divisions

Cooperative ResearchCommissioned Research

Grants and Endowments

Number of Sources

１件

８件

２０件

Amount(in thousands)

３，
５
００

５
０，
６８４

１
６，
５
０２

Site and Buildings
Location
Buildings（!）

１
２−４Sakamoto１chome Nagasaki−city
Institute of tropical medicine
（７，
６
６
３!）

Animal Research Center（４９０!）

Agreement of Educational, Scientific and Scholaly Exchange
Name of organization of partner countries

Concluded date

Chiang Mai University (Thailand)

February，
１９８８Mahidol University (Thailand)

November，
１９９９Philippines University Diliman (Philippines)

April，
２００１

Institute of Hygiene and Epidemiology (Vietnam)

June，
２００１

Airlangga University (Indonesia)

January，
２００４

St. Luke's Medical Center (Philippines)

February，
２００４

SAH LAZARO HOSPITAL MEDICAL CEHTER (Philippines)

August，
２００４

KENYA MEDICAL RESEARCH INSTITUTE (KENYA)

November，
２００４

THAMMASAT University (Thailand)

March，
２００６―３
１―

Location map of the Institute ofTropical Medicine on SakamotoCampus of Nagasaki University

PlaygroundGymnasium

Laboratory Animal Center
for Biomedical Research

Parking
Medical Materials
Center for Atomic
Bomb Casuality

Radioisotope
Center
Sub-Gate

Parking

Research Center for
Tropical Infectious Diseases
In part of the
1st and 2nd Floor(

Main Building of
the Institute ofTropical Medicine
School of Medicine
AtomicDiseaseInstitute

Animal Research Center

Main Gate
MedicalBranchLibrary
AlumniHall

Commemoration
Hall

Pompe
Hall

Back GateN

for University Hospital

―３
２―

)

Telephone Number
Institute of Tropical Medicine, Nagasaki University ………………………………………０
９５（８４９）７８００
Extensions
Dean ………………………………………………………………………………………４７００

８４９‐７８０１

Head of Administrative Office ……………………………………………………………４７０１

８４９‐７８０２

Chief of General Affairs Unit ……………………………………………………………４７０２
General Affairs Unit ………………………………………………………………………４７０３

８４９‐７８０３

General Affairs Unit ………………………………………………………………………４７０６
General Affairs Unit ………………………………………………………………………４７０７

８４９‐７８０６

General Affairs Unit ………………………………………………………………………４７０８
Chief of Collaboration Research Unit ……………………………………………………４７０９
Collaboration Research Unit ………………………………………………………………４７１０

８４９‐７８０７

Facsimile …………………………………………………………………………………４７０５

８４９‐７８０５

Meeting Room ………………………………………………………………………… ４
７１１
Department of Virology
Professor …………………………………………………………………………４７３３

８４９‐７８２７

Associate Professor ………………………………………………………………４７３４

８４９‐７８２８

Information ………………………………………………………………………４７３５

８４９‐７８２９Facsimile …………………………………………………………………………４７３６

８４９‐７８３０

Department of Bacteriology
Professor …………………………………………………………………………４７３７

８４９‐７８３１Lab．
２ ……………………………………………………………………………４７３８

８４９‐７８３２

Lab．
１ ……………………………………………………………………………４７３９８４９‐７８３３

Department of Protozoology
Professor …………………………………………………………………………４７４１

８４９‐７８３５

Lab．
２ ……………………………………………………………………………４７４２

８４９‐７８３６

Lab．
１ ……………………………………………………………………………４７４３

８４９‐７８３７

Information ………………………………………………………………………４７４４

８４９‐７８３８Department of Parasitology
Professor …………………………………………………………………………４７２８

８４９‐７８２２

Staff room …………………………………………………………………………４７２９８４９‐７８２３

Lab ………………………………………………………………………………４７３０

８４９‐７８２４

Information ………………………………………………………………………４７３１

８４９‐７８２５

Department of Molecular Epidemiology
Professor …………………………………………………………………………４７７０

８４９‐７８６０

Department of Thermal Adaptation
Professor （Concurrent）…………………………………………………………４７２６

８４９‐７８２０

Department of Biochemistry
Professor …………………………………………………………………………４７５４

８４９‐７８４８

Lab．
１ ……………………………………………………………………………４７５５

８４９‐７８４９

Culture room ………………………………………………………………………４７５６

８４９‐７８５０

Information ………………………………………………………………………４７５７

８４９‐７８５１―３
３―

Department of Pathology

Extensions

Professor …………………………………………………………………………４７１９８４９-７８１３

Associate Professor ………………………………………………………………４
７２０

８４９-７８１４

Information ………………………………………………………………………４７２１

８４９-７８１５

Staff room ………………………………………………………………………４７２２

８４９-７８１６

Information ………………………………………………………………………４
７８０

８４９-７８７０

Department of Internal Medicine
Professor …………………………………………………………………………４７４６

８４９-７８４０

Associate Professor ………………………………………………………………４７８２

８４９-７８７３

Information ………………………………………………………………………４７４７

８４９-７８４１

Information ………………………………………………………………………４７４８

８４９-７８４２

Facsimile …………………………………………………………………………４７４９８４９-７８４３

Department of Preventive Medicine and AIDS Research
Lab ………………………………………………………………………………４
７５０

８４９-７８４４

Information１ ……………………………………………………………………４７５１

８４９-７８４５

Information２ ……………………………………………………………………４７５２

８４９-７８４６

Department of Vector Ecology & Environment
professor …………………………………………………………………………４７１６

８４９-７８１０

Staff room ………………………………………………………………………４７１７

８４９-７８１１

Information ………………………………………………………………………４７１５

８４９-７８０９

Facsimile …………………………………………………………………………４７１８

８４９-７８１２

Department of Social Environment
Professor …………………………………………………………………………４７７４

８４９-７８６４

Research Associate ………………………………………………………………４７７５

８４９-７８６５

Information ………………………………………………………………………４７７６

８４９-７８６６

Facsimile …………………………………………………………………………４７７７

８４９-７８６７

Department of Environmental Pyhsiology
Professor …………………………………………………………………………４７２４

８４９-７８１８

Associate Professor ………………………………………………………………４７２５

８４９-７８１９

Information ………………………………………………………………………４７２６

８４９-７８２０

Facsimile …………………………………………………………………………４７２７

８４９-７８２１

Animal Research Center
Information ………………………………………………………………………４７６２

８４９-７８５６

Laboratory ………………………………………………………………………４７６３

８４９-７８５７

Research Center for Tropical Infectious Diseases
Lab．
１ ……………………………………………………………………………４７７８

８４９-７８６８

Lab．
１ ……………………………………………………………………………４７７９

８４９-７８６９

Lab．
２ ……………………………………………………………………………４７１４

８４９-７８０８

Museum …………………………………………………………………………４７５９

８４９-７８５３

Central Laboratory
Electron Microscope Room ………………………………………………………４
７６５

―３
４―

８４９-７８５９

Location map of the Institute of Tropical Medicine,
Nagasaki University in Nagasaki City

INSTITUTE OF TROPICAL MEDICINENAGASAKI UNIVERSITY

Mt. Inasa

Ｎ

Ropeway

Nagasaki Bay

Urakami

fo

rK

og

ak

for Akasako−
OhashiuraHamaguchi-machi
Urakamieki-mae
Nagasaki−
Ohato

Igakubu-mae

Nagasakieki-mae

School of
Dentistry
University
Hospital

School ofMedicine

Urakami−tenshudo-mae

Isibashi
Tsukimachi

Prefectural OfficeInstitute of Tropical
Medicine

City Hall−−
Chuobashi−−
Kokaido-mae
Suwajinja-mae−
Shokakuji-shita

JR Kyushu
Streetcar
Main bus routfor Mogi

for Hotarujaya

TE

OF T R OPICA

THE I N S

Y・

DICINE

AS

FO

UNDED

AK

2
194

I UNIV

２００６

IT

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熱研案内パンフ（欧文）表紙４−１ CMYK 山道 芦塚 加藤 宮副SEPTEMBER

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Published on September３
０，
２
０
０
６
Edited by Institute of Tropical Medicine, Nagasaki University
Printed by Showado Printing Co.,１００７‐２ Nagano machi, Isahaya８
５
４
‐
０
０
３
６，Japan

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How to get the Institute
１．From Nagasaki Station （JR Kyushu）!Get on a bus (Nagasaki Bus, Line ８）at Nagasakieki-mae and get off at Igakubu-mae.
Five minutes walk from the bus stop.
"Get on a streetcar at Nagasakieki-mae（for Akasako, Line １or３）, and get off at
Hamaguchi-machi. Ten minutes walk from the streetcar stop.
#Ten minutes by taxi from the station.
２．From Urakami Station（JR Kyushu）!Twenty minutes walk.
"Five minutes taxi.
３．From Nagasaki Airport!Get on limousine at the airport（for Nagasaki）, and get off at Nagasaki-ekimae, andthen continue to１．
"Get on limousine at the airport（for Nagasaki）, and get off at Ohashi, and then twenty
minutes walk from the bus stop or ５ minutes by taxi.
#About one hour by taxi from the airport.
Location
１‐
１
２‐４ Sakamoto Nagasaki ８５２‐
８５２３
URL http://www.tm.nagasaki-u.ac.jp

ER

S

背は２mm
（決定：宮副）