INSTITUTE OF TROPICAL MEDICINENAGASAKI UNIVERSITYTE

OF TROPIC

THE I N S

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through Scientific Discovery and its Application Solving the World Health Problem

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2014

MISSION STATEMENT
Institute of Tropical Medicine (ITM), Nagasaki University
The tropics, the most ecologically diverse region on the Earth, presents an ongoingcomplexity of tropical diseases and other health problems. In view of the remarkableadvances made in the field of international exchange in recent years, it is imperative thatthese problems be addressed from a global perspective.
Based on this understanding, the Institute of Tropical Medicine, Nagasaki University,
aims to overcome tropical diseases, particularly infectious diseases, and the various healthproblems associated with them, in cooperation with related institutions, to strive forexcellence in the following areas:
1. Spear-head research in tropical medicine and international health
2. Global contribution through disease control and health promotionin the tropics by applying the fruits of the research
3. Cultivation of the researchers and specialists in the above fields

General View of the Institute

Coverpage Photo : Kajiado County, Kenya（by Mitsuru Toda, Kenya Station）

Preface
Nagasaki University Institute of Tropical Medicine (ITM) was established in 1942 as a unique government-assisted
institution for research on tropical medicine, both in the basic and applied fields. The Ministry of Education, Culture,
Sports, Science and Technology (MEXT) designated ITM as a “Collaborative Institute” and a “Center of Excellence” in1982 and 1995 respectively. In 1993, the World Health Organization designated ITM a WHO Collaborating Centre for
Reference and Research on Tropical Viral Diseases. Most recently, in 2009, ITM was authorized as a “Tropical
Medicine Research Center of Joint Usage” supported by MEXT, This recognition underlines the importance of ITM as
an open institute whose resources are freely available to the whole research community. The current organization of
the institute involves four major research fields (15 departments, one domestic visiting department, one overseas
visiting department), two centres, and one clinical unit.

Developing countries in the tropics, the most ecologically and culturally diverse regions of the world, are sufferfrom a complex of tropical diseases, new emerging infectious diseases and life-style diseases. In view of theremarkable advances made in the field of international exchange in recent years, the industrialized countries of thetemperate zones are also affected by these problems and it is imperative that they are addressed from a global
perspective. Based on this paradigm, ITM aims to overcome tropical and emerging infectious diseases, and thevarious related health problems in the tropics and the rest of the world, in cooperation with related institutions, and to
strive for excellence in the following areas:

1. Spear-head research in tropical medicine and international health
2. Global contribution through disease control and health promotion in the tropics by applying the fruits of theresearch
3. Cultivation of the researchers and specialists in the above fields

This pamphlet offers a brief but hopefully intelligible explanation of our organization and its activities in research,education and other related social activities. As you will see, our research activities address traditional tropicaldiseases such as malaria, schistosomiasis, dengue fever, yellow fever and acute respiratory infections, and emerging
infections such as HIV/AIDS and SARS. We conduct basic, epidemiological and clinical research for disease
prevention and control. We also investigate environmental factors including vectors, and natural and social
environments. ITM educates students in PhD and Masters courses as part of the Graduate School of Biomedical
Science and Graduate School of International Health Development of Nagasaki University. In addition, ITM provides athree-month training course on tropical medicine. You will also find information about our research bases in Kenya andVietnam. Finally, the financial status of the institute is summarized.
Your suggestions, support and ideas for the further development of ITM are greatly appreciated.
July, 2014
Kouichi Morita
Dean and Professor
Institute of Tropical Medicine (ITM)
Nagasaki University— 1 —Contents
Preface ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Contents ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Historical Review ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Successive Deans of the Institute ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Organizational Chart ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Research Center on Tropical Diseases ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥The Steering Committee for the Collaborative Research Center on Tropical Medicine ‥‥‥‥
Character of research organization and activities ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Graduate Courses ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Three-month Course on Tropical Medicine ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Public communication ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Publications ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Virology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Emerging Infectious Diseases ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Bacteriology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Protozoology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Parasitology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Immunogenetics ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Eco-epidemiology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of International Health ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Vector Ecology & Environment ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Clinical Medicine ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Pediatric Infectious Diseases ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Clinical Product Development ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Center for Infectious Disease Research in Asia and Africa
Kenya Research Station‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Vietnam Research Station ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Tropical Medicine Museum ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Central Laboratory ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Clinic at the University Hospital ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Number of Staff ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Accounting ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Grant-in-Aid for Scientific Research from the Ministry of Education,
Culture, Sports, Science and Technology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Grant-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare ‥‥‥‥
Subsidy ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
External Fund
Agreement of Educational, Scientific and Scholarly Exchange ‥‥‥‥‥‥‥‥‥‥‥‥‥
Telephone Number ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Location map of the Institute of Tropical Medicine on Sakamoto Campus of Nagasaki University ‥

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Historical Review

were launched. In the ensuing year, the Infectious
Animals Depriva-tion Experiment Laboratory was
promoted to be-come the Animal research Center for
Tropical Infections, and the second building expansion
was concluded in March, 1980. In September, 1983, a
JICA-sponsored group training program Tropical
Medicine Research Course was opened, theDepartment of Protozoology was established a year
after, and the third building extension was finished inJuly the year after that. Two years later, the Departmentof Medical Entomology was created and the Institutewas reorganized into the collaborative institute inanother two years. In 1991, the Department ofBiochemistry was added, and the fourth building
expansion was ended in March, 1994. In April, 1994,
the Institute was divided into three big Divisions,Tropical Microbiology, Pathogenesis and Clinical
Sciences, and Environmental Medicine, with theestablishment of two new research Departments,
Thermal Adaptation and Social Environment, whichhave expanded to 12 Departments at present. The
Institute was desig-nated as Center of Excell-ence inthe forefront of scientific research in 1995, and a newresearch Department, Molecular Epide-miology, wasestablished under the Research Field of Microbiology in1996 to invite overseas visiting professors. In 1997, theReference Room for the Tropical Medicine was
replaced by the Tropical Disease Information andReference Center, and it was again succeeded by the
Research Center for Tropical Infectious Disease in
2001. In March, 2003, when the Sakamoto build-ing
finalized its fifth expansion, its extension work of almost
40 years came to an end. In March, 2006, the mainbuilding's repair work was completed. In April, 2008,
the Research Center for Tropical Infectious Disease for
the Tropical Medicine was replaced by the Center for
Infectious Disease Research in Asia and Africa andTropical Medicine Museum. In June, 2009, the institute
was authorized as the Collaborative Research Center
on Tropical Disease by the Ministry of Education. Morerecently, two additional depatments on clinicalmedicine, i.e., pediatric infectious diseases and clinicalpharmaceutical science, were admitted for installation.
In June, 2013, the Animal Research Center for
Tropical Infections was closed.
In April, 2014, Tropical Medicine Museum was
relocated to Nagasaki University Museum of Medicine.

The Institute of Tropical Medicine, Nagasaki
University was originally founded in March 1942 as theEast Asia Research Institute of Endemics, Nagasaki
Medical College in order to perform basic and appliedstudies on endemic diseases in East Asia. At the
beginning, most of its research activities were fieldstudies conducted in mainland China by the
Departments of Pathology, Bacteriology, Internal
Medicine, and Dermatology of Nagasaki Medical
College. August 9th, 1945, the atomic bomb was
dropped in Nagasaki, and the Institute's all the facilities
and research materials were completely destroyed
together with Medical School. Consequently, thedevelopment of the Institute and its research activities
had lagged significantly behind.
In April, 1946, the Institute changed its name to
the Research Institute of Endemics, Nagasaki Medical
College, and moved to Isahaya City in May to resume
research activities. Yet in accordance with the National
School Establishment Law issued in May, 1949, theInstitute once again changed its name to the ResearchInstitute of Endemics, Nagasaki University. In 1957, theInstitute was affected by another disaster of massive
flooding, and its facilities, equipment, and researchmaterials were severely damaged. Thus, constructionof a new building started in Sakamoto, Nagasaki City in
1960, and the Institute moved to the building in April ofthe following year. The Institute's Departments, whichwere only two at the time, Pathology and Clinics,
increased its number every year after 1963, including
Epidemiology, Parasitology, and Virology. The
Sakamoto building finished its first expansion at theend of 1966.
In June, 1967, with the partial alteration of the
National School Establishment Law, the name of theInstitute was changed for the third time to the present
one to carry out basic and applied studies on tropical
medicine. Around the same time, the Department ofInternal Medicine, Institute of Tropical Medicine,
equipped with 20 beds, was opened in the University
Hospital. In 1974, the Department of Bacteriology andthe Reference Center were attached, and in 1978, theDepartment of Preventive Medicine, consisting mainlyof visiting professors, associate professors, andresearchers, and the Tropical Medicine Training Course— 3 —Successive Deans of the Institute（East Asian Research Institute of Endemics）
Susumu Tsunoo

M a y. 04, 1942 - Aug. 22, 1945

Kohei Koyano

D e c . 22, 1945 - Jan. 23, 1948

Kiyoshi Takase

J a n . 24, 1948 - Aug. 31, 1948

Noboru Tokura

Sept. *1, 1948 - May. 30, 1949

（Research Institute of Endemics）
Noboru Tokura

M a y. 31, 1949 - Aug. 31, 1958

Nanzaburo Omori

Sept. 01, 1958 - Nov. 30, 1963

Hideo Fukumi

Dec. 01, 1963 - May. 31, 1967

（Institute of Tropical Medicine）
Hideo Fukumi

J u n . 01, 1967 - Nov. 30, 1969

Daisuke Katamine

D e c . 01, 1969 - Nov. 30, 1973

Kaoru Hayashi

Dec. 01, 1973 - Nov. 30, 1977

Tatsuro Naito

D e c . 01, 1977 - Nov. 30, 1979

Daisuke Katamine

D e c . 01, 1979 - A p r. 01, 1981

Keizo MatsumotoA p r. 02, 1981 - A p r. 01, 1991

Hideyo Itakura

A p r. 02, 1991 - A p r. 01, 1993

Mitsuo Kosaka

A p r. 02, 1993 - A p r. 01, 1997

Akira Igarashi

A p r. 02, 1997 - May. 31, 2001

Yoshiki Aoki

A p r. 01, 2001 - May. 31, 2007

Kenji Hirayama

A p r. 01, 2007 - May. 31, 2011

Tsutomu Takeuchi

A p r. 01, 2011 - May. 31, 2013

Kouichi Morita

A p r. 01, 2013 - Up to the present— 4 —Organizational Chart

Department of Virology
Department of Emerging Infectious Diseases
Microbiology
and Parasitology

Department of Bacteriology
Department of Protozoology
Department of Parasitology
Department of Molecular Epidemiology(Overseas Visiting Professor)
Department of lmmunogenetics
Department of Host-Defense Biochemistry

Host and Vector
Biology

Depanment of Pathology
Department of Preventive Medicine and AIDS Research

Department of Eco-epidemiology
Department of International HealthPublic andEnvironmental Health

Department of Global Health Development Policy Sciences
Department of Vector Ecology and Environment

Dean

Faculty
Meeting

Department of Clinical Medicine
Clinical Medicine
and Research

Department of Pediatric Infectious Diseases
Department of Clinical Product Development

Center for Infectious Disease Research in Asia and Africa
Kenya Research Station
AssociatedFacilities

Vietnam Research Station
Tropical Medicine Museum
Central Research Laboratory
Office for Training and Education

Nagasaki
University
HospitalInternal Medicine

Department of Infections Diseases— 5 —Research Center on Tropical Diseases
Our institute is the one and only public sector
supported by MEXT (Ministry of Education, Culture,
Sports, Science and Technology, Japan) that aims todo the research on tropical diseases, and identified as
the Collaborative Research Center on Tropical
Disease.

through exchanging information or technologies
necessary. The Research Center on Tropical Medicine
is also to deliver bio-resources including infectious
agents, information, and etc. collected and stored
here, and thus serves as a resource center on Tropical
Medicine.

1. The Goal of the Center
The infectious diseases are caused by thecollapse of symbiosis with other creatures, whichcannot be avoided if we, human being, live in thenature. Although the ultimate aim of this center is toeradicate infectious diseases, it is needed rather toestablish reciprocal relationship with other creatures
than to eliminate them. Such establishment ofreciprocal relationship requires the collective
knowledge, which can be achieved only by combining
a broad aspect of disciplines.
The Tropical Infectious Diseases have been
spreading in the tropical area, which is the reflectionof environment and socio-economic situation existed
there. It is considered to be a big challenge related tohealth. As a matter of fact, emerging and re-emerging
infectious diseases including newly emerging
infectious diseases, HIV and tuberculosis have been
spreading globally with tropical area being its
epicenter. The tropical area is not only the battle field
where we, human being, fight against them but also
the experimental ground where we newly create anddevelop our knowledge and technology alike in order
to control infectious diseases.
The Research Center on Tropical Diseases is toaccomplish with the members in the diverse scientificcommunities collaborative researches rooted upon thefield where infectious diseases are prevailing, making
use of the facilities like Asia and Africa Research
Stations internationally recognized. It also serves as aresource center for information and biological samples
related to infectious diseases speeding globally.

3. Organizational Chart of the Center
As for administration of this research center, thedean of the Institute of Tropical Medicine establishedthe Steering Committee for the Collaborative
Research Center on Tropical Medicine, which wascomposed of 11 members, out of whom more thanhalf should be outside the university concerned. The
Steering Committee for the Collaborative ResearchCenter on Tropical Medicine is responsible for
adoption of the applications and monitoring andevaluation of the activities in question.
In order to support activities above mentioned,
the specific section supporting the Research Center
on Tropical Medicine was newly formed and aprofessor was designated to be a section chief.
4. Applications for Collaborative Researches
There were 34 applications for collaborative
researches, out of which 24 were adopted.
There were 3 applications for collaborative
researches specified research area, out of which 3
were adopted.
There were 1 applications for research meeting,out of which 1 were adopted.

2. Outline of the Collaborative Research
The Research Center on Tropical Medicine
appeals to the public for the collaborative research,which is either basic or applied research based uponepidemiological, clinical or public health framework.
The Research Center on Tropical Medicine appeals tothe public for the research meeting, which promotes
and facilitates the research of infectious diseases— 6 —Concept Diagram
The Institute ofTropical Medicine

The Tropical Medicine
Research Center Committee

Researchers' Communities

Dean

Discuss important matterson its management

Send a delegate/delegates as amember of the committee to address
opinions from communities

Advice / Report

Expert advisors

Discuss specialized mattersthat are inquired

The Tropical Medicine
Research Center Office
Support for its management and follow
the intention of the committee— 7 —Research Grants
A collaborative Research Topic
A collaborative Research Topic
A collaborative Research Topic

The Steering Committee for the Collaborative
Research Center on Tropical Medicine
Committee Member outside the university
National Reseach Center for Protozoan Diseases,
Obihiro University of Agriculture and Veterinary Medicine◎ Professor

Ikuo Igarashi

Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
Director

Nobukatsu Ishikawa

Professor

Fumiko Oshikawa

Center for Integrated Area Studies, Kyoto University

Department of Tropical Medicine and Malaria ResearchInstitute National Center for Global Health and Medicine
Director

Shigeyuki Kano

National Institute of Infectious Diseases
Deputy Director-General
Ichiro Kurane
RIKEN Center of Research Network for Infectious Diseases
Director

Yoshiyuki Nagai

Graduate School of Biomedical Sciences

Professor

Noriyuki Nishida

Atomic Bomb Disease Institute

Professor

Noboru Takamura

Institute of Tropical Medicine

Professor

Toshiya Hirayama

Institute of Tropical Medicine

Professor

Taro Yamamoto

Institute of Tropical Medicine

Professor

Koya Ariyoshi

Committee Member outside the instituteCommittee Member inside the institute◎：Chairman— 8 —Character of researchorganization and activities

Graduate Courses
In April 2002, the structure of doctoral course in
Nagasaki University was re-organized by integrating thethree graduate schools from the Schools of Medical
Science, Dental Science and Pharmacology into the
Graduate School of Biomedical Sciences. The school
now offers six master and doctoral courses. All the
departments in the Institute of Tropical Medicine (ITM)
are involved in teaching the Course on Infection
Research. In April 2013, the “Program for Nurturing
Global Leaders in Tropical and Emerging Communicable
Diseases” was incorporated in this course. Limited to
15 students per year, the new program is one of theseveral programs adopted by the Program for Leading
Program supported by the Ministry of Education,
Culture, Sports, Science and Technology. It focuses oncontrolling tropical and emerging infectious communicablediseases and on leadership. One of its unique features
is that students will be given practical trainings in across-field curriculum, which includes hands-on
training at overseas Nagasaki University Research
Stations in Kenya and Vietnam and other internationalorganizations. In addition, 22 staff of ITM composed ofprofessors, associate professors and assistantprofessors participate in this program. They play animportant role in giving lectures related to tropical andemerging communicable diseases and in helping
students to write their dissertations.

Based on the following research organizationand intimate linkages with other research institutes
and universities, the institute aims at accomplishinga mission Spear-head research in tropical medicine
and international health.
●To study comprehensively the tropical diseases
which are raging in the developing countries,
research organization of the institute consists of 4
major research fields which deal with the classic
quad
of
the
human-agent-environment
determinant-clinical study of infectious diseases
and Overseas Research Station and Tropical
Medicine Museum. Other facilities of the instituteinclude a joint research laboratory and a tropical
medicine education office.
●The research of tropical medicine faces theinevitable fact that the bench is in the bush.
Therefore the institute has a close linkage with theoverseas institutes in Asia, Africa and SouthAmericas and continues the joint studies.
Memorandums of academic exchange programs
were signed between Nagasaki University and 16
overseas institutes. Since the overseas researchlaboratories of the institute has been established in
Kenya Medical Research Institute (KEMRI), Kenya
and National Institute of Hygiene andEpidemiology (NIHE) Vietnam in 2005, by the
grants from Ministry of Education, Sports, Culture,
Science and technology (MEXT), the extensive andlongitudinal studies on tropical diseases has beenon the progress, and are extended to continue inmore 5 or 6 years. We have extended our effort toachieve external funds for this project andobtained the Special Coordination Funds for
Promoting Science and Technology and theScience and Technology Research Partnership for
Sustainable Deve-lopment (SATREPS), etc. These
funds have expanded the researches at Asia andAfrica stations.
●The prevalence of tropical diseases depends onthe geographic, social and economic factors.
Therefore the institute has established the special
research system which helps forward themultidisciplinary studies on tropical diseases.

〈 Master of Tropical Medicine (MTM)〉
In 2006, Nagasaki University Graduate Schoolof Biomedical Sciences opened the Master ofTropicalMedicine(MTM)
course,which
accommodates 12 students from various countries.
This one-year course starts from October with one
month of lectures/ practice on conducting research,followed by research period leading to Master thesis
writing supervised by respective professors. From
April to June, they have intensive lectures andpractices on Clinical Tropical Medicine and TropicalPublic Health. Degree of Master of Tropical Medicine
is awarded to successful students. The applicant
should have more than two years of clinicalexperience as a medical doctor, and should havesufficient communication skill in English.
〈Master of Public Health (MPH)〉
In April, 2008, the Graduate School ofInternational Health Development was founded at
Nagasaki University. The main aim is to cultivate
specialists who contribute to the promotion of good
health in developing countries. A Master of Public
Health (MPH) degree is awarded to students who
successfully complete this two-year course. Since
tropical medicine plays a pivotal role in promoting
good health internationally, four professors from ITM
serve as a full-time faculty member in the program.
The applicants are required to have sufficientcommand of Japanese language.
The information on these courses including
application form is available through our homepage.
http://www.tm.nagasaki-u.ac.jp/nekken/english/index.html— 9 —Three-month Course on
Tropical Medicine

accumulate know-how of risk communication on
tropical infectious diseases in our institute, we areplanning to have open lectures where we have frankcommunication with citizens on the present stateand future prospects of research on tropical
medicine.

This is a short-course of tropical medicine. This
course aims to support medical and co-medical
personnel who plan to work in the tropics, byproviding opportunities to learn a broad range ofskills and knowledge relevant to practicing medicine,
implementing disease control programs andconducting medical research in tropical anddeveloping countries. The course began in 1978.
Fifteen participants are accepted to attend thecourse in each year. As of the 36th course in 2013,455 participants in total (including 186 medical
doctors, and 269 co-medical such as nurses,
community health nurses, midwives, pharmacists)from all over Japan have completed the course. The
course is run by the steering committee, which
consists of members from both inside and outside
the Institute of Tropical Medicine (ITM).
The full-time staff members of the ITM and asubstantial number of visiting professors andlecturers provide the 13 weeks (April to June, in2014) of lectures, laboratory practicals and fieldwork in the fields of virology, bacteriology,
protozoology, parasitology, medical entomology,
pathology, immunogenetics, epidemiology, humanecology, social medicine, clinical medicine and also
geography and culture in tropics. Participants who
successfully completed the course are awarded the
Diploma in Tropical Medicine.

Publications
Our official publications are as follows;
1. Bulletin of Nagasaki University Institute of Tropical
Medicine (in Japanese, yearly since 1964, PDF
files are available at our web page.)
2. Japanese Brochure (in Japanese yearly since1977, PDF files are available at our web page.)
3. English Brochure: INSTITUTE OF TROPICALMEDICINE NAGASAKI UNIVERSITY (this copy.
Yearly since 1977, PDF files are available at our
web page.)
4. Report of Nation-wide Cooperative Research
Projects (Information of research activities andachievements as a nation-wile cooperative
research center for tropical medicine is compiled.)

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4

Admisssion ceremony in 2014

Public communication
Lectures and film shows for citizens are heldoccasionally. Every year, several groups of highschool students with teachers visit our museum,attending lectures and film shows. In 2013, we had
3 open lectures at Nagasaki City Library. To— 10 —

Department of Virology

re-designated in 2003. The Department has beencollaborating with WHO in training for WHO fellows
from many developing countries and deployment ofexperts as WHO short-term consultants. In addition,
Dr. Kouichi Morita was dispatched to WHO/WPRO
as Regional Adviser on Communicable Diseases
from 16 May 1995 to 15 May 1998. Dr. Futoshi
Hasebe was also dispatched for a long term tocollaborate in the global emerging infectious disease
control program from March 2004 to March 2006.
The Department initiated and held the FirstGOARN/WHO National Training Course in Nagasaki
from 25 to 29 February 2008 in collaboration with
WHO/WPRO.

This Department has been conducting basic
and applied research on mosquito-borne viruses
such as Japanese encephalitis (JE) virus, dengue
virus and West Nile virus, as well as emerging
infectious viruses such as SARS virus and Nipah
virus.
Molecular epidemiology of Japanese encephalitis andDengue viruses
We isolate JE and dengue viruses in Asia andAfricanregionsandconduct
molecular
epidemiological analysis to clarify international andinter-continental movement of those viruses. We
also analyze unique genome sequences that are
relevant to pathogenicity.

Kouichi Morita
Professor
Futoshi Hasebe
Professor (Project)
Shingo Inoue
Assistant Professor
Fuxun Yu
Assistant Professor
Takeshi Nabeshima
Assistant Professor
Daisuke Hayasaka
Assistant Professor
Visiting Research Fellow Buerano Corazon Cerilla
Visiting Associate Professor Masanobu Ago
Toru Kubo
Visiting Researcher
Mitsuru Toda
Technologist
Guillermo Posadas Herrera
Research Fellow
Mya Myat Ngwe Tun
Research Fellow
Muhareva Raekiansyah
Research Fellow
Yuki Takamatsu
Research Fellow
Kazumi Jodai
Assistant
Takako Chiba
Assistant
Akira Yoshikawa
Graduate Student
Reo Uchida
Graduate Student
Ulanday Gianne Eduard Limbo
Graduate Student
Adungo Ferdinard
Graduate Student
Aung Kyaw Kyaw
Graduate Student
Satoshi Shimada
Graduate Student
Phu Ly Minh Huong
Graduate Student

Research on animal and organ specificity of
Flavivirus
JE virus infects more efficiently in swine,
whereas dengue virus multiplies well in humans. We
are identifying the molecular basis for such hostspecific infection of flaviviruses.
Research on viral gene functions and vaccine
development using reverse genetics
We have developed infectious clones for JE anddengue viruses and identify gene functions bymodifying various parts of the genes or constructing
chimeric viruses between the two viruses. In
addition, we are developing genetically engineered
viruses as candidates for live attenuated vaccines.
Development of rapid diagnosis
Various tools for rapid diagnoses are being
developed for flaviviruses and other emerging
viruses using PCR, LAMP and nLC/MS
technologies. Also, genetically engineered antigens
are being developed to provide affordable
serological tests for developing countries.
Research on emerging viral infectious diseases
Epidemiological studies on SARS virus, Severe
Fever and Thrombocytopenia Syndrome virus (SFTS)
and H5N1 avian influenza virus are being conductedin Viet Nam, Japan and other countries in the South
East Asia.
Activities as a WHO Collaborating Center
The Department of Virology is designated as a
WHO Collaborating Center for Reference andResearch on Tropical Viral Diseases' since 1993 andEpidemiological study of tick-borne viruses— 11 —

Department of Emerging
Infectious Diseases

transmission. We have developed novel diagnostic
assay for emerging viral diseases.
Studies on Lassa fever in Nigeria
Lassa fever is a viral hemorrhagic fever and now
endemic in West African countries. Annually
300,000-500,000 peoples are infected with Lassa
virus and 5,000 patients have died in Lassa fever
every year. We are carrying on the epidemiologicalstudies, the development of novel diagnostic
methods and the pathological studies on Lassa
fever in collaboration with a Nigerian group.

Emerging infectious diseases are infectious
diseases whose incidence in humans haveincreased in the past 20 years and threaten toincrease in the near future. We are working on the basic
research to develop and produce countermeasuresagainst emerging infectious diseases, especially viralhemorrhagic fevers and influenza.
Research subjects:
Analyses of replication mechanisms of highly
pathogenic viruses
In infected cells, the viruses replicate using
various cellular machinery and release a large
number of progeny virions. Our interests are toclarify the molecular mechanisms of virus replication
in host cells. We are currently analyzing themolecular interactions between viral proteins andcellular factors in virus infected cells. Especially, we
are focusing on highly pathogenic viruses, such as
Ebola, Marburg, Lassa and Influenza viruses.

Studies on endogenous retroviruses
Recently, it has been reported that a portion oflive attenuated vaccines for pets, which were
produced using mammalian cell lines, were
contaminated with infectious endogenous retrovirus.
Furthermore, in therapeutic use of animal cells,
tissues, and organs derived from pigs as donors forxenotransplants, a major international concern is thepossibility of cross-species transmission of infectious
porcine endogenous retrovirus from animal donor to
immunosuppressed human transplant patients. To
reduce the risk induced by endogenous retrovirusesin vaccine preparation and xenotransplantation, weare developing the strategies to regulate theproduction of endogenous retroviruses from cells.

Development of novel antiviral strategies
To establish novel antiviral strategies against
viral hemorrhagic fevers and influenza, we are
identifying the cellular factors which have antiviral
activity and analyzing the molecular mechanisms of
their antiviral action. We will also start highthroughput screening of organic and chemicalcompound libraries for antiviral drug discovery
against viral hemorrhagic fevers.

Professor
Assistant Professor
Assistant Professor
Assistant Professor
Postdoctoral Fellow
Research Fellow
Research Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student

Development of detection methods for highly
pathogenic viruses
In case of outbreak of emerging infectious
diseases, rapid and accurate diagnosis is essential
to control infection and to prevent further

Molecular Mechanism of Marburg virus budding

Jiro Yasuda
Yohei Kurosaki
Shuzo Urata
Saori Sakabe
Yukiko Uno
Sayaka Okada
Mayuko Kobayashi
Tomomi Kamiyama
Chisato Narahara
Yukiko Hirota
Sayuri Nakamae

Collaboration research work in the South Africa
BSL-4 facility— 12 —

Department of Bacteriology

functions as a receptor for VacA and produces thedisease associated with VacA toxicity including gastritis
and gastric ulcer [3].
More recently, we purified from AZ-521 cells, ahuman gastric epithelial cell line, a surface membraneprotein, p500, which binds VacA, and identified it as
low-density lipoprotein receptor-related protein-1(LRP1). LRP1 binding of VacA was shown to be
specifically responsible for VacA-induced autophagy
and apoptosis, but not activation of the Wnt/β-cateninsignaling pathway. Similar to RPTPα and RPTPβ,
LRP1 mediates VacA internalization in AZ-521 cells, but
in contrast to RPTPα and RPTPβ, LRP1 targeted
downstream pathways leading to autophagy andapoptosis. VacA-induced autophagy via LRP1 binding
precedes apoptosis suggesting that an excessive
autophagic activity can also lead to cell death. This is
the first study to provide evidence that LRP1 mediates
autophagy [8]. Surprisingly, CagA, which is an
oncogenic protein injected by its type IV secretion
system into host cells, was degraded by autophagy
induced by m1 VacA, but not m2 VacA, whereas CagA
in CD44v9-expressing cancer stem-like cells escaped
this autophagy system, resulting in accumulation of
CagA in cells [9].

Our major research interest is to elucidate the
etiologic agents isolated from pathogenic bacteria
related to the worldwide emerging and reemerging
diseases and to know the virulence mechanisms ofbacterial pathogens.
Helicobacter pylori is a bacterial pathogen found in
the stomach mucosa of more than 50% of the world
population and more common (over 80%) in developing
and tropical countries. Infection with H. pylori plays amajor role in the development of chronic gastritis andpeptic ulcer, and is a risk factor for gastric cancer.
Pathogenic strains of H. pylori secrete a potent protein
toxin, a vacuolating cytotoxin, termed VacA, whichcauses progressive vacuolation of epithelial cells andgastric injury. We found that VacA induces multiple
effects on epithelial cells, including mitochondrial
damage [1] and apoptosis [2]. These actions of VacA
appear to result from activation of cellular pathways,
independent of those leading to vacuolation. Similarly,
VacA-induced phosphorylation of G proteincoupled
receptor kinase-interactor 1 (Git 1), which may be
responsible for epithelial cell detachment caused by
VacA, leading to peptic ulceration [3], and VacAinduced activation of p38/ATF-2-mediated signal
pathway [4] are independent of VacA effects on cellularvacuolation.
Analysis of VacA receptors provided new insights
into the molecular basis of VacA function. We reported
that two VacA proteins, termed m1 VacA and m2 VacA,
which were defined by sequence differences in the
middle of the molecules, interacted with target cells bybinding to two types of receptor-like protein tyrosine
phosphatases (RPTPs), i. e., RPTPα and RPTPβ,resulting in toxin internalization and vacuolation of thehuman gastric adeno-carcinoma cell lines AZ-521 andG401 [5, 6, 7]. By analysis of the pathologicalresponses of wild type and RPTPβ-deficient mice tooral administration of VacA, we found that RPTPβ

References:[1] Microb. Pathog. 31:29-36, 2001[2] J. Biol. Chem. 281: 11250-11259, 2006
[3] Nat. Genet. 33: 375-381, 2003
[4] J. Biol. Chem. 279: 7024-7028, 2004[5] J. Biol. Chem. 278:19183-19189, 2003
[6] J. Biol. Chem. 279: 51013-51021, 2004
[7] Cell Microbiol 7: 1285-293, 2005[8] J. Biol. Chem. 287:3104-3115, 2012[9] Cell Host Microbe. 12: 764-777, 2012
Professor
Senior Assistant Professor
Assistant professor
Assistant

Virulence mechanism of Helicobacter pylori
vacuolating cytotoxin, VacA

Toshiya Hirayama
Akihiro Wada
Masayuki Nakano
Kayo Maeda

Laboratory— 13 —

Department of Protozoology

sialidase2) Stage specific adaptation mechanisms employedby different Trypanosoma species

Malaria is responsible for a huge burden ofdeath and disease in large areas of the tropical andsub-tropical world. Unfortunately, those countries
hardest hit by the disease are often amongst thepoorest. Despite continuing efforts, there is still noeffective vaccine against the disease. In order todesign and implement effective disease intervention
strategies, we believe that one of the key priorities inmalaria research should be the strengthening of ourunderstanding of the basic biology of the parasite.
We are currently investigating some fundamental
aspects of the parasite’s life cycle, such as themechanisms behind red blood cell (RBC) invasion
and the phenomenon of cytoadherence of parasiteinfected RBCs using human malaria parasite
Plasmodium falciparum and rodent malaria parasite
Plasmodium yoelii. In addition, we are also
conducting research aimed at elucidating theintracellular survival strategy of Trypanosma cruzithat cause Chagas disease and Babesia parasitesthat cause Babesiosis in cattle.
We are actively pursuing the following lines ofinvestigation:

3. Babesia
1) Molecular basis of host cell invasion and modification
2) Establishment of gene manipulation techniques
on Piroplasma parasites
Professor
Visiting Professor(Dept Mol Epidemiol)

Osamu Kaneko
Thomas James Templeton

Senior Assistant Professor Haruki Uemura
Assistant Professor Shusuke Nakazawa
Assistant Professor Kazuhide Yahata
Assistant Professor Masahito Asada
Shinya Miyazaki
Research Fellow
Kittisak Thawnashom
Research Fellow
Hassan Hakimi
Research Fellow
Visiting Researcher Kishor Pandey
Visiting Researcher Wataru Kagaya
Mika Takeda
Assistant
Miki Kinoshita
Assistant
Momoko Ogoshi
Assistant
Reiko Tanaka
Assistant
Yoshimi Matsuo
Assistant
Joe Kimanthi Mutungi
Graduate Student
Amuza Byaruhanga Lucky
Graduate Student
Yuto Kegawa
Graduate Student
Kwame Kumi Asare
Graduate Student

1. Malaria
1) The molecular basis of host cell invasion by parasites
2) The molecular basis of cytoadherence of parasiteinfected RBCs
3) Transcriptional control in malaria parasites
4) Recrudescence of malaria parasites5) Calcium signaling in malaria parasites
6) Establishment of a continuous Plasmodium vivax
culture system
7) Molecular epidemiology of malaria parasites inendemic countries
8) Transmission dynamics of Plasmodium knowlesi,a zoonotic monkey malaria parasite
2. Trypanosoma
1) The function and expression mechanism of trans-

P. falciparum expressing a calcium biosensor. Fluorescenceresonance energy transfer (FRET) signal from the same
parasite is shown in pseudocolor before (left) and after(right) adding an inhibitor of calcium-dependent ATPase.

RBC invasion by P. yoelii. Merozoite-stage parasite(arrowhead) invades into RBC within 30 seconds (0 - 25 s)
and deformed RBC to spike-like shape (85 s).

Recombinant protein (green) expressed in P. falciparum
co-localized with Maurer's cleft protein (red) seen in the
RBC cytosol outside of the malaria parasite. Nucleus isvisualized with blue color.
— 14 —

Department of Parasitology

mechanisms against Leishmania major, L. donovani,
Trypanosoma cruzi, and T. congolense, and in theprocess, have elucidated the function of the IL-12
cytokine family such as IL-27/WSX-1 during
infection. After we developed animal models ofintestinal amoebiasis together with Prof. Houpt atUniversity of Virginia, we elucidated thepathogenicity of Entamoeba moshkovskii, andnow are devoting ourselves to the study onmolecular basis of pathogenicity of E. histolytica,
E. moshkovskii and host defense mechanisms toEntamoeba spp.

Infectious diseases are still a huge menace tohuman health and continue unabated in tropicalareas under the conditions of poverty and theunique natural and social environments. Various
kinds of parasites infect humans for long periods oftime without killing them, giving rise to tremendous
social and/or economic loss. We would like todevelop deep insight into parasitic diseases and thesurrounding factors from various points of view
through both field and laboratory studies. Our goal is
to contribute to new knowledge and to provide an
enthusiastic environment for the training of the future
generation of investigators.

3. Cohort study using HDSS on infectious diseases in
Mbita and Kwale area in Kenya
We carried out cross-sectional study on
infectious diseases in Mbita and Kwale area using
HDSS (Health and Demographic Surveillance
System) as the collaboration with Niigata University
and Department of Eco-epidemiology. In 2011, thefeasible studies on shistosomiasis, other helminthic
and protozoan infections, HIV/AIDS, tuberculosis
and so on were launched.

Target diseases of our studies
We have been carrying out both field andlaboratory studies on several of the most importanthelminthic diseases, including schistosomiasis,
filariasis and intestinal helminthiasis and on importantbut neglected protozoan diseases such asamoebiasis, leishmaniasis and trypanosomiasis.

Professor
Assistant Professor
Assistant Professor
Assistant Professor
Technologist
Assistant
Assistant
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

1. Schistosomiasis and Filariasis
In 2011, in cooperation with Kenya Medical
Research Institute (KEMRI), we started a research
project on parasitic diseases in Mbita and Kwale,
Kenya. In the laboratory, we have been maintained
Schistosoma mansoni and intermediate snails andare trying to elucidate immune responses as well as
to develop sensitive and specific diagnostic methods
through the study on the unique molecules
belonging to Schistosoma spp.
A research project on filariasis was also carriedout in Mbita and Kwale, Kenya, in cooperation withKEMRI. In order to contribute to "Filaria Elimination
Program" by WHO, we collaborate with Aichi
Medical College. In the laboratory, Brugia malayi, B.
pahangi and the vector mosquito, Aedes aegypti
have been maintained for many years.
2. Amoebiasis, Leishmaniasis, Trypanosomiasis etc.
Genetic epidemiology and cohort studies onamoebiasis and leishmaniasis are carried out incooperation with the International Centre for
Diarrheal Disease Research, Bangladesh (ICDDR, B.)
and the University of Virginia. Field sites include
Dhaka and rural areas of Bangladesh. In addition to
genetic factors, we aim to elucidate various
environmental factors that determine and/or
influence the outcome and transmission of theinfection. In the laboratory, we study host defense

Shinjiro Hamano
Yoshinori Mitsui
Kentaro Kato
Risa Sonoda
Kyoko Masuda
Megumi Hamasaki
Tomoko Takaya
Fumie Hara
Hiromi Oda
Shumpei Kambe
Sachiyo Nagi
Yombo Dan Justin Kalenda
Kenichi Nobusue
Taeko Moriyasu
Sharmina Deloer
Eman Sayed Mohammed Hassan

One of our field site in Nepal, South Asia
— 15 —

4. Dengu fever
1) Pathogenesis of the DHF (Dengue Hemorragic
Fever)HLA, Mast Cell derived factors, related toseverity
2) Early stage predictors for severe Dengue fever
Free DNA, Chymase, VEGF

Department of Immunogenetics
This department is focusing on the pathogenic
genetic factors of the host and the parasite in themost important tropical infectious diseases by using
immunology and genetics.
Research activities:
To clarify the molecular mechanisms in the protective
and/ or pathogenic host response to humanpathogens such as Dengue Virus, Malaria,
Trypanosoma cruzi and Schistosoma, the following
research projects are going on in our laboratory.

Collaborations:
The research here is performed based on thewell-arranged collaborative projects with thefollowing facilities.
1. Malaria: Karolinska Institute (Sweden), Kenya
Medical Research Institute (KEMRI). London
School of Hygiene and Tropical Medicine,
Univeristy of Liverpool
2. Schistosmiasis: Jiangxi Provincial Institute ofParasitic Diseases (China), Jiangsu Provincial
Institute of Parasitic Disease (China), RITM
(Philippines).
3. Chagas Disease: Center of Tropical Medicine,
Sirani Clinic, and Hospital Japones (Bolivia), IICS
University of Asuncion (Paraguay).
4. Dengue Fever: Ho Chi Minh Pasteur in Vietnam,
Pasteur Paris, MacMaster University

1. Malaria
1) Genetic susceptibility to severe forms of malaria(cerebral malaria, severe anemia)
TLR-9, IgGR, TNF-alpha2) Vaccine development
Py Legumain (Transamidase18p)DNA vaccinewith nanoparticle delivery system
2. Schistosomiasis
1) Vaccine and Drug target molecules identification
by genomics and proteiomics
SEA motif bearing gene family
3. Chagas disease
1) Genetic susceptibility to different clinical typesof chronia Chagas disease, namely,indeterminate, cardiac, and digestive forms
HLA-B14 haplotype as resistant against chronic
complications2) Host and Parasite factors influencing on thereactivity to the chemotherapy in the paediatricpatients with chronic Chagas Disease. On
going3) Compound library screening by using in vitro
culture of T.cruzi
Astellas open innovation network including
U.Tokyo, Tokyo Institute of Technology,
AIST(National Institute of Advanced Industrial
Science and Technology), and DNDi

Members

Professor
Associate Professor
Assistant Professor
Assistant Professor
Research Fellow
Postdoctral Fellow
Technologist
Visiting Researcher
Assistant
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Experiment scenery— 16 —

Kenji Hirayama
Nguyen Huy Tien

(Clinical Product Development)

Cherif Mahamoud Sama
Shusaku Mizukami
Mbanefo Evaristus Chibunna
Lam Quoc Bao
Tetsuo Yanagi
Yukimi Katagami
Junko Hayashima
Shiho Chikatoshi
Kuniko Shimoda
Dang My Nhi
Vasquez Velasques, Clara Alejandra
Dao Huy Manh
Oumer Ali Ahmed
Eleonor F Avenido

Fieldwork in Bolivia

○NEKKEN National BioResource
CenterTo promote life sciences it is important that
researchers share the various bio-resources
necessary for pursuing research and development.
The resources produced in years with painstaking
labor will make foundation for future researches. The
NBRP deals with the bio-resources, which will not
be able to be restored again if once they are lost. We
would like to ask the access to our Project Website.
Your cooperation and support for the project would
be highly appreciated.

The Government of Japan has been making
efforts under its second and third Science andTechnology Basic Plans to create a world-class
intellectual platform. In FY 2002 the Ministry of
Education, Culture, Sports, Science and Technology(MEXT) implemented the National BioResource
Project (NBRP) to construct the framework forsystematic collection, preservation, and distributionof bio-resources, with a focus on those that required
strategic development by the National Government.
Since 2002 Institute of Tropical Medicine(NEKKEN), Nagasaki University has been taking of
Division of Protozoa in Pathogenic Microorganismsof a Core Facility Upgrading Program under Medical
Mycology Research Center, Chiba University.
NEKKEN NBRP contributes the services toresearchers, (1) information of owners and strains ofpathogenic protozoans in Japan on database
Website, (2) supply of protozoans from NEKKEN
NBRP, (3) acceptance of protozoan deposit to
NEKKEN NBRP and the preservation, (4) supply of
protozoan specimens for laboratory practice of
medical- educational schools, (5) examination for
protozoan infections from any medical facilities.

http://www.nbrp.jp/
http://pathogenic.lab.nig.ac.jp/ns.jsp
E-mail : protozoa@tm.nagasaki-u.ac.jp
Project Representative
Collaborator
Collaborator
Technician
Information Desk

— 17 —

Kenji Hirayama
Shinjiro Hamano
Richard Culleton
Tetsuo Yanagi
Shiho ChikatoshiDepartment of Eco-epidemiology

The ultimate purpose of the department is toform a theory for a better understanding of theinterrelationship between hosts and pathogen andits consequences, diseases.

April 2008, the Research Center for Tropical
Infectious Diseases was reorganized andtransformed into four groups i.e. two departments in
the Research Field of Environmental Medicine,
Tropical Medicine Museum and the Kenya station ofOverseas Research Stations.

Ongoing activities are 1) research using Health and
Demographic Surveillance System (HDSS), 2)
Establishment of African center for multiple assay
method, surveillance system and integrated control
programs for a wide range of pathogens ofneglected tropical diseases (NTDs), 3) A child healthcohort study from the viewpoint of sociology,
anthropology and epidemiology in a marginal area ofAfrica, 4) Application of the vein patternauthentication system to epidemiological studies
and social identification in developing countries, 5)
Public health research on Dengue fever control in Sri
Lanka and 6) Epidemiological investigation andsurveillance development in the JICA noncommunicable disease project in Sri Lanka.

Therefore, Eco-epidemiology department
inherited its philosophy of research from the
Research Center for Tropical Infectious Diseases, as
one of the departments in the Research Field ofEnvironmental Medicine. The mission is to contributeto the global control of the tropical infectious
diseases by analyzing the complex factors that
regulate the endemics and/or epidemics of thediseases to find appropriate control measure of theinfection.
The concept of eco-epidemiology is based on
the view of recognizing tropical diseases as asystem of infection. The aim of our research is tounderstand the process of interaction between
microorganisms, vectors and human beings in thesystem. Therefore, the staffs mainly work in the fieldat the Kenya Research station of Overseas Research
Stations.

Professor
Satoshi Kaneko
Assistant Professor Yoshito Fujii
Research Fellow
Masashi Miura
JSPS Ronpaku Researcher Samson Nzou Muuo (Kenya)
Assistant
Emi Nakayama
Graduate Student
Tomonori Hoshi

Human beings and vectors, so-called hosts as
a niche of pathogens, exist not statically but
dynamically in time and space. In addition, there isan infinite diversity in the characteristics of hosts. We
study how microorganism survive, maintain,
proliferate, diminish, disappear and emerge throughthe niches.

Child health survey with finger veinauthentification system

Nairobi laboratory for multiple assay A scene at health and demographic
for a wide range of pathogens ofsurveillance system(HDSS)in
neglected tropical diseases
Lao PDR— 18 —

Department ofInternational Healthepidemiology, detection of DNA footprint, next
generation sequencer, bio-informatics, mathematicalmodel. In addition to these researches of infectious
diseases, we decided to add the historical approachbased on documentary records in order tounderstand widely the relationship between
creatures and societies.
Another pillar is a social responsibility. Now thateven profit oriented organizations are required tohave its corporate social responsibility, no need tosay for academia or university. Out of the name ofour department, it must be nothing but contribution
to international health or people's health in resource
limited settings.
Our department raises following three activities
as international contribution; advocacy oninternational health at national and international level,
health promotion activities and empowerment at thecommunity/ grassroots' level and emergency relief.
What our department thinks of important inthose activities is to make solidarity in order toimprove people's health and contribute to people's
sustainable development. It is our department's
goal.

Department of International Health has started
its activities since 2008, following the internal reformof Institute of Tropical Medicine. Department ofInternational Health has its basis on ResearchCenter for Tropical Infectious Diseases (RECTID) of
Institute of Tropical Medicine established in 2001,
Information and Reference Center in 1997, andReference Center in 1994.
It says that RECTID, a precursor of ourdepartment, had following three activities; 1)
developing the museum of tropical medicine, 2)collecting and disseminating information on tropicalinfectious diseases and 3) promoting joint research
projects and doing epidemiological studies. Out of
which, Department of International Health takes overresearch activities and adds to its mandate aninternational collaboration as a social responsibility
anew. Thus, Department of International Health, as a
newly established department, has two pillars, e.g.
research and social responsibility.
Research was composed of three units; 1)
research on infectious diseases in ecosystem, 2)
research on the environment including climatechange and Asian dust related to health, 3) researchon biological evolution of microorganisms from theadaptation or fitness view point and 4) research on
the epidemiology from the historical viewpoint. The
umbrella concept or key word linking above four
research units is to reconstruct infectious diseases"temporally" and "spatially" alike. Infection is the
biological interaction between hosts andmicroorganisms. In other words, host behavior,social structure as well as culture per se affectmicroorganisms in fitness and adaptation whereas
microorganism has impact on its hosts. Based onthat perception, our department aims to get moredetailed understanding and insight on infectious
diseases. For examples, we would like to pursue theways of analysis by various approaches such as
molecular-evolutional
technique,molecular

Professor
Assistant Professor
Assistant Professor
Research Fellow
Visiting Researcher
Visiting Researcher
Visiting Researcher
Assistant
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student— 19 —Taro Yamamoto
Takayuki Wada
Tomoo Ichikawaa
Mami Hayashita
Taijin Kaku
Md Ubydul Haque
Guoxi Cai
Yasushige Egoshi
Rui Okabe
Yoshimi Misumi
Katsura Igai
Shuko Takahashi
Yoshihiro Takayama
Shihomi YoshidaDepartment of Vector
Ecology & Environment

and monitoring their insecticide resistance in East
Africa.
Professor
Associate Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant
Assistant
Assistant
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Our research interests include anything from
ecology to molecular biology of medically important
arthropods, particularly mosquitoes that transmit
diseases such as malaria and dengue. We are alsointerested in their relationships with environmental
variables and development of environmentallyfriendly vector control tools.
1. Dengue vectors
As dengue vectors are extending theirgeographic distribution, the spread of the disease isbeing concerned. It has been suspected that the
expansion of vector distribution is due toenvironmental factors such as climate change. We
are currently mapping their geographicaldistributions in South East Asia and Africa, andexamining the relationships with environmental
factors.
2. Malaria vectors
We are examining ecological and physiologicaldifferences among the members within the
Anopheles gambiae complex group and theAnopheles funestus group in Kenya and Malawi. We
are also investigating their geographic distributions,and monitoring their abundance in East Africa. Thisextensive field survey was designed to understandthe effects of climate and develop a climate basemalaria prediction model.
3. Vector control measures
The coverage of insecticide treated bed nets
(ITNs) has considerably increased in Africa. We areinvestigating whether local residents properly use
and maintain ITNs, and how long ITNs last. We arealso investigating the effects of bed nets on thespecies composition of vectors and their behavior,— 20 —

Noboru Minakawa
Hitoshi Kawada
Toshihiko Sunahara
Yukiko Higa
Takashi Tsunoda
Kyoko Futami
Ataru Tsuzuki
Chaves Sanabria Luis Fernando
Chiaki Tsurukawa
Emiko Kawashima
Naoko Mori
Kogomi Minagawa
Junko Sakemoto
Koji Yamada
Yusuke Sumita
Eugenio Fonzi
Huynh Thi Thuy Trang
Nozomi Imanishi
Owuor Gabriel Owino
Sai Zaw Min OoDepartment ofClinical Medicine

Thailand, we conducted a cohort study targeting HIVinfected individuals and their spouses in Lampang Hospital,
northern Thailand between July 2000 and December 2010;nearly 2000 people participated. The main objectives of thiscohort are to understand mechanisms of resistance to HIV
infection among HIV-exposed but uninfected spouses livingwith HIV-infected patients and mechanisms of slowprogression among HIV-infected slowprogressors. Data andsample analysis are still continuing as collaboration between
Thai counter parts and international experts in hostgene
polymorphisms, molecular immunology, molecularepidemiology and virology.

Our main research interests are respiratory infectious
diseases, tuberculosis (TB), HIV/AIDS and tropical infectious
diseases. We are the only department of clinicians in NEKKEN
and conduct a wide range of multi-disciplinary studies linking
our strength of clinical epidemiology to laboratory-based
microbiology and immunology studies both in- and outside
Japan. Specific research activities are described as follows:
1. Respiratory Infections Diseases
We have developed multiplex-PCR assays to identify 19
different viral and bacterial respiratory pathogens and also
developed a novel nanofluidic real time PCR-based assay todetermine 50 pneumococcus serotypes. These molecular
assays are now being applied for several clinical studies
including a multi-center epidemiological study for adultpneumonia in all over Japan and childhood acute respiratory
infection study in central Vietnam. In 2009, we commenced abirth cohort studies, recruiting approximately 2,000 pairs ofmothers and new-born babies, which facilitates studies ofhost-gene polymorphisms associating the severity ofpediatric infectious diseases. For the development of a novel
treatment strategy, we also investigate the pathogenesis oftreatment-refractory pneumonia at molecular levels focusing
on macrophage function, of clearing apoptotic cells from theinflammation site. We hypothesize that an impaired process
in inducing the cessation of inflammation and repair ofdamaged tissues plays a central role.

Professor
Associate Professor
Assistant Professor
Assistant Professor
Research Associate
Visiting Researcher
Visiting Researcher
Visiting Researcher
Assistant
Assistant
Assistant
Assistant
Assistant
Research student
Research student
Research student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student

2. Tuberculosis
For better-diagnosis of latent MTB infection andtuberculosis, we are analyzing cellular immune responses tovarious TB antigens using a flowcytometory or a QFT combinedwith Luminex to evaluate a range of cytokines profile in various
stages of TB infection and their contact cases both in Japanand the Philippines. Our goal is to clarify TB-specific cellularimmune responses characteristic to a different clinical stage of
TB infection. We are also investigating pathogens causing
bacterial pneumonia and its impact on the survival prognosis of
TB patients admitted to the National Infectious Diseases
Hospital (San Lazaro Hospital) in the Philippines.
3. Clinical Research in Infectious Disease Hospitals in the tropics
In collaboration with National Institute of Infectious
Diseases, Tokyo, we are conducting undiagnosed febrileillness study in the Department of Infectious Diseases, Bac
Mai Hospital, Hanoi, Vietnam by applying diagnostic tests
for leptospirosis and various richettial diseases. In
collaboration with the San Lazaro Hospital, the Philippines,
we are conducting leptospirosis study to evaluate the new
diagnostic test and to improve clinical management. We
also run a bed-side clinical training course on tropicalinfectious disease with UK infectious disease consultants.
4. HIV Cohort Studies in Northern Thailand
In collaboration with National Institute of Health,

Koya Ariyoshi
Konosuke Morimoto
Motoi Suzuki
Hikaru Sato
Kiwao WatanabeMichio Yasunami
Masahiko Mori
Yoshiro Yamashita
Rina Shiramizu
Kyoko Uchibori
Yumi Hamasaki
Hitomi Nakamura
Satsuki Shiraishi
Mayumi Terada
Yoshitaka Harada
Masahiro Takaki
Tohru Ogasawara
Sugihiro Hamaguchi
Kensuke Takahashi
Reiko Miyahara
Nobuo Saito
Takaharu Shimazaki
Ikumi Shimada
Satoshi Kakiuchi
Tomoko Ishifuji
Dhoubhadel Bhim Gopal
Ngo Chi Cuong
Emi Kitashoji
Hiroshi Fujii
Shungo Kato
Rena Osawa
Kenichi Nobusue
Mai Izumida
Hirotomo Yamanashi
Kentaro Hayashi

Bed-side clinical training course in San Lazaro Hospital— 21 —

Department of Pediatric
Infectious Diseases

demographic, social-behavioral data collection anddisease burden study on SPID. We also obtained
hospital databases from two hospitals covering theregion. Utilizing these large databases, we were able
to investigate on a variety of SPID in Vietnam. In
addition, to determine incidence, viral etiology andrisk factors for pediatric ARI/pneumonia, we areconducting a population based hospitalized
Pediatric ARI surveillance at Khanh Hoa General
Hospital, Nha-Trang since 2007.

Activities
The Department of Pediatric Infectious Diseases
is a recently expanded department under the ClinicalResearch Division at Institute of Tropical Medicine.
We work on a wide range of infectious diseases withspecial attention on severe pediatric infectious
diseases including pneumonia, diarrhea, dengue andmalaria. Our research interests include integration ofclinical, environmental and social issues atinternational, national and local levels.

Birth cohort study
Currently we are also conducting a birth cohort
study on 2000 new born babies in Nha Trang,
Vietnam. This study was conducted in collaboration
with the Pediatric Department of Nagasaki University
to study congenital infection and host genetic
factors on physical-neurological development of thechild and development of SPID.

Pediatric Respiratory Infections
Our department has a strong collaboration with
the Department of Pediatrics of Nagasaki University.
We regularly received clinical samples to identify viraland bacterial pathogens from pediatric cases
admitted to the Nagasaki University hospital withsevere respiratory infection. We are also conducting
pneumococcal serotyping and antibiotic sensitivity
testing of Streptococcal pneumoniae strains fromcases with invasive pneumococcal diseases inJapan. Currently we are developing an advancemolecular serotyping technique using nanofluidic
technology to determine the S.pneumoniae serotype
directly from clinical samples.

Health impact of global environmental change
Our research interests cover most ofenvironmental epidemiology. Current substantive
research topics of interest, on which we work incollaboration with both international and Japanesecolleagues, focus mainly on the impacts of weather
and global climate change on health, but also
include health risks of air pollution.
Ongoing projects include: 1. Effects of flooding andweather on cholera, acute respiratory infections andother infectious diseases in Bangladesh. 2. Oceanatmosphere interaction phenomenons including
Indian Ocean Dipole and its association with malaria
and cholera in the East Africa. 3. Health effects ofAsian dust in the East Asia. 4. Intervention study toprevent heat-related illness in Japan. 5. Excess
mortality due to influenza in Southeast Asia.

Cohort study on Pediatric Infectious Diseases in Vietnam
This study is conducted with funding from theJapan Initiative for Global Research Network on
Infectious Diseases (JGRID). Our main counterpart in
Vietnam is the National Institute of Hygiene andEpidemiology (NIHE), Vietnam. We have been
conducting a large population based cohort study
on Pediatric Infectious Diseases at Khanh Hoa
Province, central Vietnam since 2006, to determine
the etiology and risk factors for severe common
pediatric infectious diseases (SPID) like acuterespiratory infection (ARI), diarrhea and dengue
which are the major causes of under 5 mortality. The
study site covers a population of 353,525 residing in
75,826 households with 24,781 children less than 5
years. We conducted population census,

Professor
Associate Professor
Assistant
Assistant
Graduate student
Graduate student
Graduate student
Graduate student

Pediatric infectious diseases research in Vietnam

Masahiro Hashizume
Lay Myint Yoshida
Nozomi Oka
Setsuko Hirakura
Chisato Imai
Noriko Takahashi
Michiko Toizumi
Keisuke Yoshihara

Environmental change andglobal health research in Bangladesh— 22 —

Department of Clinical
Product Development

product development, clinical data management,
good laboratory practice and etc.
2. Research1) Development of Shiunko for Cutaneous
Leishmaniasis;2) Identification and further development of Herbal
Medicine for Breast cancer, Cholangiocarcinoma
and Malaria.
3. Network
1) Coordination of Product Research andDevelopment (PRD) Network
2) Coordination of research ethics global networkStrategic Initiative for Developing Capacity in
Ethical Review (SIDCER)

This is a newly established department inresponse to the Global Strategy on public health,innovation and intellectual property (resolution
WHA61.21).
The resolution calls for theenhancement of health-needs driven research anddevelopmenttoaddress
diseasesthat
disproportionately affect developing countries. The
establishment of this department was supported by
the Department of Academic and Research
Promotion, Ministry of Education, Culture, Sports,
Science and Technology (MEXT), Japan. MEXT
continues to support the department until its fulldevelopment.

Collaborations:
1. Drug Research Center, Thammasat University,
Bangkok, Thailand
2. SIDCER, National Research Council of Thailand(NRCT), Bangkok, Thailand
3. Armauer Hansen Research Institute, Ministry of
Health, Addis Ababa, Ethiopia
4. Institution of Human Research Protection,
Ministry of Health, Thailand
5. Tokyo University, Tokyo, Japan
6. Government Pharmaceutical Organization,
Bangkok, Thailand

The department focuses on:
1. building capacity of individuals for innovation in
health product2. strengthening capability of the local research
institutions in providing an enabling environment,
including infrastructure for product R&D
3. strengthening research institutes network forknowledge sharing and exchange, and for R&D
technology transfer activities. The emphasis will
be on developing products for public healthneeds to address the issues of inequity in health.
4. Development of health products

Professor
Associate Professor
Assistant Professor
Visiting Professor
Assistant
Graduate Student

The operation of this department depends onthe collaboration of existing offices and departments
in NEKKEN and in Nagasaki University, e.g. Office
for Training and Education, Immunogenetics,
Toxicology, Clinical Pharmacy, Parasitology, Clinical
Medicine, Clinical Paediatrics, Center for infectious
disease research in Asia and Africa and the research
institutions and universities in developing countries.
The aim of its operation is to ensure that research
priorities of research institutions are in line with their
public-health needs, in particular the need forinnovative research to address the health problemsof their populations and to contribute to improved
public health in other countries.
The activities:
1. Training
1) Two- week course on Product Research andDevelopment for public health needs;
2) Three-day course on Bioethics
3) PhD training as part of actual product development
ie. Shiunko for Cutaneous Leishmaniasis, Herbal
Medicine for Cholangiocarcinoma and Malaria (seemodel below);4) PhD training as part of associated productdevelopment processes e.g. ethical issues in— 23 —

Juntra Laothavorn
Nguyen Huy Tien
Eduardo Jose Kawasaki
Kesara Na-Bangchang
Ikumi Fritz
Nut Koonrungsesesomboon

Center for Infectious Disease
Research in Asia and Africa

in Western Kenya, bacterial and viral diarrheal
disease and mosquito-borne hemorrhagic fever has
continued at the P3 lab in Nairobi Office and at the
KEMRI (Kenya Medical Research Institute)
Production Department. In Kwale, epidemiologicalresearch of schistosomiasis haematobium has been
conducted. As the “The Project for Development of
Rapid Diagnostics and the Establishment of an Alert
System for Outbreaks of Yellow Fever and Rift Valley
Fever in Kenya” of JST-JICA (SATREPS) launched in
March 2012, we completed setting up two KEMRI
labs at the KEMRI Production Department and in
Busia. Meanwhile, a lab for seroepidemiology projectfocusing on NTD (neglected tropical diseases) was
set up with a fund by Japan Science andTechnology Agency, and the project started in April
2013.
5.Educational Programs
Three researchers and doctors from Kenya
graduated from the Master of Tropical Medicine at
the Institute of Tropical Medicine in Nagasaki. Every
year, we give opportunities for three graduate
students to study in the field in Kenya from the
School of International Health Development at
Nagasaki University. We also have accepted
students from medical school students from Osaka
University, Osaka City University, and Shiga
University of Medical Science for field trainings.

○Kenya Research Station

OutlineNagasaki University Kenya Research Station isan overseas research site that has been establishedthrough the “Program to Establish Infectious Disease
Research Network” funded by the Ministry of
Education (MEXT) in September 2005- March 2010.
Since April 2010, the site received renewed funding
from MEXT under the “Tropical Medicine, Emerging
Infectious Disease and Clinical EpidemiologicalResearch Program to Establish Education andResearch System for the collaboration of Kenya andJapan”.
The goals of this project are to strengthen the
Kenya Research station, to train young researchers
on research of emerging and re-emerging infectious
diseases, and to collaborate with local researchers
on long-term research projects.
Progress
1.Establishing of The Research Sites
We have made progress on setting up the
Kenya Research Station in Nairobi (including
setting up the Biosafety Level 3 laboratory andother laboratories) and field research sites in
Mbita, Kwale, Kisumu and Busia. Building
renovation, setting up conference rooms andinformation systems, and vehicle procurement are
currently ongoing.
2.Posting Researchers From JapanThe members of the station include two
professors (including a representative), two
assistant professors, and three administrative staff
members. An assistant professor and a researcher
are working as JICA experts for STAREPS project.
Five professors, another associate professor andthree assistant professors have supported our
project through short-term visits.
3.Management for the Long-Term Research and Communities
In Mbita area, Health and Demographic
Surveillance System (HDSS) has collected data on
population, births and death rates, and incidencesof diseases. Mosquito surveillance System (MSS)
has collected and analyzed data on malaria
mosquitos in the area. We began a new projectthrough JICA Partnership Program focusing onschool health in Mbita area that has been ongoingsince 2009.
HDSS and parasitology research havecontinued in Kwale since 2010.
4.The Study of Tropical Medicine
Research on malaria and mosquito transmission

NUITM Kenya Research Station(Nairobi Office)Project Members
Leader and Professor Yoshio Ichinose (Kenya)
Noboru Minakawa
Professor
Shinjiro Hamano
Professor
Masahiro Hashizume
Professor
Masaaki Shimada (Kenya)
Professor
Masahiro Horio
Professor
Satoshi Kaneko
Professor
Associate Professor Hitoshi Kawada
Assistant Professor Shingo Inoue (JICA Expert/ Kenya)
Assistant Professor Kyoko Futamii
Assistant Professor Yoshito Fujii
Assistant Professor Mohammad Shah
Assistant Professor Rie Takeuchi (Kenya)
Assistant Professor Peter Larson (Kenya)
Mitsuru Toda (JICA Expert/ Kenya)
Research Fellow
Masashi Miura
Research Fellow
Administrative/HR Manager Yukie Saito (Kenya)
Masayuki Kotani(Kenya)
Chief Accountant
Administrator (Coordinator) Haruki Kazama(Kenya)
Tomoka Tawara
Administrator
Contracted Administrator Mitsuo Takatoh (Kenya)
Shunpei Kanbe
Graduate Student
Gabriel Dida
Graduate Student
Ernest Apondi
Graduate Student

Our members

Mbita Research Site
— 24 —

Kwale Research Site

2. Vector-Borne Infectious Diseases Research Group:
1) Study on biological properties, virulence andecological significance of dengue viralquasispecies in mosquito vectors and humans
2) A survey of Japanese encephalitis virus
migration3) A study of the influence of arbovirus on
seasonal encephalitis of unknown origin
4) A survey of climate change, mosquito vectors,
and virus infection5) A study of mosquito vectors, pathogenic
mechanism of dengue fever, and anti-infection
measures
6) Inter-regional study on dengue virus and vector
mosquitos
7) A study of simian malaria in Vietnam
3. Clinical Research Group:1) Pediatric acute respiratory infection cohort
research study2) A birth cohort study3) An immunogenetical analysis of severe dengue
fever at Choray Hospital4) Establishment of a clinical and epidemiologicalresearch data collection system for analysis of
the fever of unknown origin
4. Zoonosis Research Group:
1) A viral epidemiological study of bat-borne
infectious diseases
2) A molecular epidemiological study of rabies
3) An epidemiological study of hantavirus
4) Development of human monoclonal antibody
with neutralizing activity against avian influenza(H5N1) strain
5) An epidemiological study of avian influenza

Center for Infectious Disease
Research in Asia and Africa○Vietnam Research Station

Outline
NEKKEN and National Institute of Hygiene andEpidemiology, Vietnam (NIHE) jointly conducted a
project from 2005 on clinical and epidemiologicalresearch on Emerging and Re-emerging Infectious
Diseases (ERID) granted by the Ministry of
Education, Science, Culture and Technology (MEXT)
of Japan. Consequently, Vietnam Research Station
was established and a number of research activities
conducted by investigators from both NEKKEN and
NIHE. In the framework of the collaborative project
conducted by two institutes, researches on theenvironmental and social factors influencing
outbreaks of zoonosis, vector-borne infectious
diseases, diarrhoea, and childhood pneumonia havebeen carried out. Having achieved goals of
aforementioned researches in the first phase project(2005-2009), the next research objectives wasunderlined, which is, clarifying the factors and theirmechanisms in causation of infectious diseases
including ERID. In the second phase, therefore, we
aim to attain aforementioned objectives andconsequently seek for medically and sociallysignificant achievements by carrying out research
activities. To conduct a worldwide study of infectious
diseases, we have a scope to network research
centers which were established in eight countries intropical zone, under the framework of the Japan
Initiative for Global Research Network on Infectious
Diseases (J-GRID).
Research activities
The objectives of the entire project are to clarify
the ecology of pathogens in nature and in humansociety, to clarify the pathogenic mechanism of
human diseases, and to develop an interventionbased method to inhibit the spread of infectious
diseases. Four research groups will conduct theirresearches pursuing their research objectives.
Research agenda are as follows:
1. Diarrhoea research group:
1) A molecular epidemiological study on kinetics ofenteropathogens after rotavirus vaccine intervention
2) A molecular epidemiological study of Vibrio
cholerae in ecosystem in Vietnam
3) Hospital based and a community based studies
of a broad range of etiological agents ofdiarrhoea in Vietnam

Staff of Vietnam research Center

NIHE-Nagasaki University Friendship Laboratory(NNFL) staff
Leader and Professor Tetsu Yamashiro
Futoshi Hasebe
Professor
Takashi Tsunoda
Assistant Professor
Taichiro Takemura
Assistant Professor
Asako Tokizawa
Assistant Professor
Takahiro Nakao
Staff
Phan Hoai Linh Ly
Research Assistant
Ung Thi Hong Trang
Research AssistantPham Thi Hang
Research AssistantTran Ly Na
Research AssistantTran Thi Luong
Research AssistantNguyen Hong Huong
Research Assistant
Bui Thi Tra
SecretaryYumiko Fukuiwa
Assistant
Mayumi Ogawa
Assistant

Japanese staff is providinga basic techniqueto perform PCR to a Vietnamese staff— 25 —

A surveillance for mosquito which
potentially transmit dengue viruses

Tropical Medicine Museum

an essential component of the daily research
activities related to tropical medicine. Due toinfrastructure rearrangement in 2012, network tools
were updated with technological innovation and long
lasting safety; thus responding to every need of theusers. We also serviced various databases, using a
research evaluation system and a database of thetropical medicine museum. Moreover, we are trying
to provide a similar environment to research
universities overseas with VPN by including videoconferencing system to promote international
conferences and e-learning plans.

Museum of Tropical Medicine was preceded by
the Tropical Medicine Reference Centre, which wasestablished in 1974 and was reorganized in 1997 as
Tropical Medicine Reference and Information Center.
In 2001, it was renamed as Research Center
Tropical Infectious Diseases (RECTID) and in 2008 it
was established as an auxiliary institution. In
addition, the present museum was relocated toNagasaki University Museum of Medicine. The
institution performs the following 2 functions.
First, it functions as a museum and resource
center for tropical disease. There is a general section
providing information on tropical diseases,
parasites/bacteria/viruses/poisonous insects andspecimen of dangerous animals, valuable books,
and displays images of the data. Moreover, it has anaudio-visual room accommodating a few numbers ofpeople. Furthermore, a system is being developedfor using this collection of resources to strengthen
public science and risk communication withthousand points relating to the history andphilosophy of tropical medicines and infection
symptoms. In the near future we would like toexpand the exhibition room to the museum of
tropical medicine and can be used as an educational
resource for society and educators and provide
tropical disease related research and successful
results for the public. In addition, we displayed
Africa's Nature, Development, and People, in March
2009, as part of the Ueno Yama Decade ofInformation series of National Museum of Nature andScience, Tokyo.
It also functions as an information center for the
dispatch, collection, organization, and analysis of
information on tropical medicine. This has become

Head and Professor Noboru Minakawa
Professor
Masahiro Horio
Technologist
Kazuo Araki
Assistant
Kiyomi Suda

The database server

Tropical Medicine Museum

Tropical Medicine Museum— 26 —

Central Laboratory(children under 5 years of age) to investigate risk
factors influence on child health in Savvannakhet
province in Lao PDR. Since then we are following up
the cohort every 2 weeks. This study will be
continued until March 2018.

The aim for Central Laboratory is operation andefficient managements for large equipment andgeneral laboratory facilities. The laboratory had
equipped that 16- and 48-cappilary sequencers, GSjunior genome sequencer and mass spectrometrybased genotyping system for genome analysis,
flowcytometer and digital cell sorter for cell function
analysis, laser confocal microscope, fluorescencemicroscope, and fluorescence-luminescenceimager
for visualizing analysis, and Luminex bead-arraysystem and fluorescence- luminescence multilabel
counter for multipurpose analysis. In addition to
general laboratory facilities such as pure watersupply, ultracentrifuge, lyophilizer, Speed-Vac,
French press, Bioruptor, sample storage in liquid
nitrogen, bio-safety cabinet, autoclave, dark roomand cold room. Those facilities were used to support
to researches of the institute and visiting
investigators.

○Pathology Unit
Main purpose of our research is fundamentally
pathological investigation of tropical diseases, mainly
infectious diseases, focused on oncogenic
microbes, and establishes the basis of theirtreatment and prevention. Although many
investigators have proposed oncogenesis due to
inflammation associated cancer development, themechanisms underlying the relationship between
chronic inflammation and cancer still remainunresolved. Therefore, our research focuses on thepotential role of oncogenic microbes in thedevelopment of cancers, highlighting the recent
advances in the understanding of the molecularmechanisms. The proportion of total cancer deaths
attributable to infectious agents is estimated to be
20% to 25% in developing countries and 7% to 10%
in industrialized countries. A causal relationshipbetween chronic inflammation and cancer is widely
accepted. Specifically, there is a strong association
between tumor viruses and the development of
human cancers. The mechanisms of oncogenesis
associated with infection and inflammation have notbeen elucidated. However, many oncogenic
mechanisms have been proposed for infection andinflammation. Activation of NF- B is also involved
cancer development and progression. Therefore, ourresearch focuses on the molecular players during
the development from chronic inflammation tocancer.

○Eco-health Unit

In order to promote people's health in the world,
it is essential to understand the health in the context
of social and ecological interactions (Eco-system).
By such multi-disciplinary approach this unit
explicates factors associated to ill-health, especially
infectious diseases which are preventable byappropriate counter measures. Main focuses are: 1)
Emerging antimicrobial resistant bacterium in aquatic
environment, 2) Problems related to tuberculosis
medication under conditions of conflict and largescale disaster, 3) Rapid changes in Eco-system andmorbidity pattern among ethnic minorities.
In October 2013, we initiated cohort studies

Lab for Genetic Analysis— 27 —

○Electron Microscope Unit

students working with us.
We are interested in all aspects of malariology,
and are currently actively engaged in research
projects involving immunology, genetics, genomics,
evolutionary theory, ecology, epidemiology, andmolecular cell biology.
Collaborative projects with malaria researchers
based in Japan and internationally are of enormous
importance to us, and make up the bulk of the work
we are currently engaged in. At present we are
actively working with researchers from the USA, theRepublic of Congo, Vietnam, Sri Lanka, Brazil, theUK and Saudi Arabia.

The electron microscope room is a NEKKENwide user facility for ultrastructural characterizationof most microbial pathogens including viral,
protozoal, and bacterial species. We offer highquality imaging services from conventional andimmuno-electron microscopy to 3D tomography,
and also provide training on sample preparation anduse of equipment. This laboratory is equipped withtransmission and scanning electron microscopes(from JEOL), high-pressure freezer (from LEICA),
ultra-microtomes (from LEICA and REICHERT),
vacuum coater, critical point dryer system, andosmium plasma coater in addition to generallaboratory facilities for a wide range application ofelectron microscopy. Here is also open to users fromother universities and institutes.

Head and Professor
Associate Professor
Associate Professor
Senior Assistant Professor
Assistant Professor
Assistant Professor
Assistant
Assistant○Malaria Unit

We are a small and highly driven malariology
group focusing on many different aspects of malaria.
Established in 2011, we believe in a multidisciplinary approach to studying malaria, as thisenables a broad understanding of the subject, andtherefore facilitates the development of novel
solutions for fighting the disease. Such a holistic
approach to disease research can only succeed,
however, on the foundation of a solid and detailed
understanding of its multi-disciplinary constituents.
Our core belief is that all our research should
produce results that are of potential practical use forfighting the disease. We also strive to engage young
researchers in studies on malaria, and hope toencourage them to develop enthusiasm for usefulscientific research. We believe that scientificresearch should be fun, and try to foster afreethinking and engaging research environment for— 28 —

Toshiya Hirayama
Richard Culleton
Junko Okumura
Mihoko Kikuchi
Masachika Senba
Miako Sakaguchi
Sarina Hokama
Risa Tatsuhara

Clinic at the University HospitalThe department of clinical medicine, theInstitute of Tropical Medicine has a clinic and is incharge of managing infectious disease ward in the
Nagasaki University Hospital. Our ward has 16 beds
with 8 negative pressure rooms, of which two can
accommodate patients with BSL4 pathogens. We
specialized in infectious diseases and respiratory
diseases; we treat patients with systemic infectious
diseases, including tropical infectious diseases,
HIV/AIDS, tuberculosis, pneumonia, and various
neoplasmic and inflammatory respiratory diseases.
We see well over 300 consultation cases a year inother wards, for giving advices on diagnosis andtreatment of infectious diseases. Outpatient clinic is
open twice a week where we also run a travel clinic
for international travelers.
For training and education, we provide anumber of lectures on infectious diseases andrespiratory diseases to undergraduate students andbed-side training programs for resident physicians.
We organize a clinical case conference of tropicalinfectious diseases as a part of Master of Tropical
Medicine course, Graduate School of Biomedical
Sciences. Staff doctors and resident doctors are
regularly dispatched for a long-term to abroad, San
Lazao Hospital, the Philippines and the infectious
disease ward in Bac Mai Hospital, Vietnam toaccumulate our knowledge and experience withclinical tropical medicine.

Professor
Associate Professor
Senior Lecturer
ssistant Professor
Assistant Professor
Assistant Professor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Senior Resident
Senior Resident
Assistant

Koya Ariyoshi
Konosuke Morimoto
Akitsugu Furumoto
Maiko Kojiro
Takeshi Tanaka
Masahiro Takaki
Hiroshi Fujii
Takaharu Shimazaki
Kensuke Takahashi
Shungo Kato
Masaharu Nobuyoshi
Tomoko Hiraoka
Kazuma Iwata
Yumi Yamamoto
Ayako Matsuo

Infectious diseases conference

Staff Members— 29 —

Number of Staff（as of May 1, 2014）

Divisions

Professor

Associate
Professor

Lecturer

Enrollment

13
(3)

5
(1)

3

※（

Assistant Research
Professor Associate
19(16)

Sub total

Others

Total

41
(20)

10
(11)

51
(31)

1

）number of fixed-term staff

Accounting（Fiscal Year 2013）
Expenditure

RevenueAmountDivisions

AmountDivisions(in thousands of yen)(in thousands of yen)

Administrative cost subsidy

757,680

Administrative cost subsidy

757,680

Non-subsidy income at Nagasaki University

208,612

Non-subsidy income at Nagasaki University

208,612

Joint Research

13,035

Joint Research

22,901

External Commissioned Research
Fund
Commissioned Project

384,171379,90928,577External Commissioned Research
Fund
Commissioned Project

Endowment

18,900Endowment

43,49827,675

OthersTotal

28,028

22,100

Others1,438,650

1,462,728

Total

Grant-in-Aid for Scientific Research from the Ministry of （FY 2013）
Education, Culture, Sports, Science and Technology
Scientific Research
Aid forType of Scientific Scientific Scientific Scientific Challenging Young
Young
Research on Fellowship for launching
Exploratory
Research Research(A) Research(B) Research(B) Research(C) Research Scientists(A) Scientists(A) Innovative Areas Young Scientists research activiy

Total

Numberof Grants

3

Amount35,880(in thousands)

11

1

10

6

1

9

1

1

1

44

63,9608,840

16,77011,4406,370

13,91019,500

1,100

1,430

179,200

Facilities & Administrative costs included

Grant-in-Aid for Scientific Research from
the Ministry of Health, Labour and Welfare
Type of
Research

Global Health
Issues

HIV/AIDS

Emerging and Reemerging
Infectious Diseases

Total

Number of
Grants

5

1

10

16

Amount(in thousands)

10,2501,600

18,95030,800— 30 —（FY 2013）

Subsidy （FY 2013）

Type of
Research

National Bioresource Project(NBRP)

Strategic Young
Researcher
Overseas Visits
Program for
Accelerating
Brain Circulation

Amount(in thousands)

4,300

23,375

Facilities & Administrative costs included

External Fund （FY 2013）
Divisions

Joint Research with
Private Sectors

Commissioned
Research

Commissioned
Project

Endowments

Number of Sources

6

14

5

27

Amount (in thousands)

13,035386,180

28,577

18,900

Facilities & Administrative costs included

Agreement of Educational, Scientificand Scholarly Exchange
Name of organization of partner countries
Chiang Mai University (Thailand)
Mahidol University (Thailand)
University of the Philippines Diliman (Philippines)
National Institute of Hygiene and Epidemiology (Vietnam)
Airlangga University (Indonesia)
St. Luke's Medical Center (Philippines)
San Lazaro Hospital Medical Center (Philippines)
Kenya Medical Research Institute (Kenya)
Thammasat University (Thailand)
Defence Research and Development Establishment (India)
National Institute for Communicable Diseases of the National Health
Laboratory Service (South Africa)
China Medical University (China)
Peking Union Medical College (China)
Jiangsu Institute of Parasitic Diseases (China)
National Institute of Malariology, Parasitology and Entomology(Vietnam)
University of the Philippines Manila(Philippines)— 31 —

Concluded dateFebruary, 1988
November, 1999
April, 2001
June, 2001
January, 2004
February, 2004
August, 2004
November, 2004
March, 2006
January, 2010
July, 2010
September, 2010
September, 2010
September, 2010
November,2013
January,2014

Telephone Number
Institute of Tropical Medicine, Nagasaki University ０９５（８１９）７８００
Extension
Dean ……………………………………………………………… ７８０１
Head of Administrative Office …………………………………… ７８０２
Expert Staff ……………………………………………………… ７８１３
Chief of General Affairs Unit …………………………………… ４７０２
General Affairs Unit ……………………………………………… ７８０３
Dean Secretary ………………………………………………… ７８５８
Chief of Accounting and Facilities Management Unit ………… ４７０６
Accounting and Facilities Management Unit ………………… ７８０７
Accounting and Facilities Management Unit ………………… ７８１６
Chief of Overseas Research Station Unit ……………………… ４７０９
Overseas Research Station Unit ……………………………… ７８０６
Facsimile ………………………………………………………… ７８０５
Main Meeting Room …………………………………………… ４７１１
Meeting Room …………………………………………………… ７８７０
Department of Virology
Professor ………………………………………………… ７８２７Assistant Professor ……………………………………… ７８２８
Information ……………………………………………… ７８２９
Facsimile ………………………………………………… ７８３０
Department of Emerging Infectious Diseases
Professor ………………………………………………… ７８４８
Staff room ………………………………………………… ７８４９Laboratory ……………………………………………… ７８５０
Information ……………………………………………… ７８５１
Department of Bacteriology
Professor ………………………………………………… ７８３１
Lab.1,Lab.4 ……………………………………………… ７８３３
Facsimile ………………………………………………… ７８７７
Department of Protozoology
Professor ………………………………………………… ７８３５
Lab.2 ……………………………………………………… ７８３６
Lab.1 ……………………………………………………… ７８３７
Information ……………………………………………… ７８３８
Senior Assistant Professor ……………………………… ７８１５
Department of Parasitology
Professor ………………………………………………… ７８２２
Staff room ………………………………………………… ７８２３
Facsimile ………………………………………………… ７８２４
Information ……………………………………………… ７８２５
Department of Immunogenetics
Professor ………………………………………………… ７８１８Senior Assistant Professor ……………………………… ７８４５
Information ……………………………………………… ７８２０
Facsimile ………………………………………………… ７８２１
National BioResource Center Information …………… ７８５６
Department of Pathology
Assistant Professor ……………………………………… ７８１４

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８１９−７８０７

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８１９−７８１４Extension
Department of Eco-epidemiology
Professor ………………………………………………… ７８６６
Assistant Professor ……………………………………… ７８６７Lab.1 ……………………………………………………… ７８５４
Information ……………………………………………… ７８６６
Department of International HealthProfessor ………………………………………………… ７８６９
Lab.1 ……………………………………………………… ７８０８
Information ……………………………………………… ７８６９
Department of Vector Ecology and Environment
Professor ………………………………………………… ７８１０
Staff room ………………………………………………… ７８１１
Information ……………………………………………… ７８０９
Facsimile ………………………………………………… ７８１２
Department of Clinical Medicine
Professor ………………………………………………… ７８４０
Associate Professor …………………………………… ７８７３
Information ……………………………………………… ７８４１
Information ……………………………………………… ７８４２
Facsimile ………………………………………………… ７８４３
Department of pediatric Infectious Diseases
Professor ………………………………………………… ７７６３
Associate Professor …………………………………… ７２８４
Information ……………………………………………… ７７６４
Department of Clinical Product Development
Professor ………………………………………………… ７２８５
Information ……………………………………………… ７５５８
Center for Infectious Disease Research in Asia and Africa
Kenya Research Station Professor …………………… ７８６０
Kenya Research Station Assistant Professor ………… ７８３２
Vietnam Research Station Professor ………………… ７８７６
Tropical Medicine Museum
Professor ………………………………………………… ７８１７
Information ……………………………………………… ７８６８
Central Laboratory
Eco-health Unit ………………………………………… ７５８２
Electron Microscope Unit ……………………………… ７８５９The Malaria Unit ………………………………………… ７９０３
Information ……………………………………………… ７８５７

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Location map of the Institute ofTropical Medicine on SakamotoCampus of Nagasaki University

PlaygroundGymnasium
Laboratory Animal Center
for Biomedical Research

Medicine Museum

Sub-Gate

General Research Building
Tropical Medicine Museum (Under construction)(In part of the 1st Floor)

Radioscope
Research Center

Parking

Main Building of
the Institute ofTropical Medhcine
Medicine(7,782㎡)
AtomicDiseaseInstitute

School of Medicine

Main Gate
MedicalBranchLibrary

Alumni Hall

Commemoration
Hall

Pompe
Hall

Back GateN
for University Hospital
RyoJunHall— 34 —

Location map of Institute of Tropical Medicine,
Nagasaki University in Nagasaki City▲
Mt.InasaN

Ropeway

Nagasaki Bay

fo

rK

og

ak

UrakamiuraHamaguchi-machi
Urakamieki-mae
Nagasaki

Ohato

Ishibashi

Tsukimachi

Akasako
Ohashi for

Igakubu-mae

Nagasakieki-mae

School of
Dentistry

Prefectural Office

University
Hospital

School ofMedicine

Urakamitensyudo-mae

Institute of Tropical
Medicine

City Hall

Chuobashi

Matsuyama-machi

Kokaido-mae
Suwajinja-mae

JR Kyushu
Electric Tramway

Shokakuji-shita

Main bus routefor Mogi

for Hotarujaya

How to get the Institute○From JR Nagasaki Station
Electric Tramway Nagasaki Station → (bound for Akasako) → Hamaguchi-machi → about 10-minute walkNagasaki Bus Nagasaki Station → (No.8 bound for Shimoohashi via School of Medicine) → School of Medicine○From JR Urakami Station
Electric Tramway Urakami Station → (bound for Akasako) → Hamaguchi-machi → about 10-minute walk
○From Nagasaki Airport
Kenei Bus Nagasaki Airport No.4 Bus Stop → (bound for Nagasaki City via Showa-machi and Urakami)→ Urakami Station → refer to from JR Urakami Station above
Location
1-12-4 Sakamoto Nagasaki 852-8523
URL http://www.tm.nagasaki-u.ac.jp
Published on July, 31 2014
Edited by Institute of Tropical Medicine, Nagasaki University
Printed by Quick Print