Keio University
Annual Report on Research Activities
2009– 2010

Keio University

Fukuzawa's Spirit of Science_ The Power to Pioneer the Future
Yukichi Fukuzawa, the founder of Keio University who lived through aperiod of dramatic upheaval before and after the Meiji Restoration, wrote ofhis contemporaries in his book, An Outline of a Theory of Civilization: "We have
lived two lives, as it were; we unite in ourselves two completely different
patterns of experience." In such periods of major transition, we are unable toconsider things based on preconceived ideas or old ways of thinking.
Against this background, what Fukuzawa emphasized was the importance of"learning." By "learning," Fukuzawa meant jitsugaku, or "science," and inparticular, "empirical science."
Today, we are also in the midst of major changes to economic and social
structures. In times such as these, it is increasingly important for us tounderstand and determine the true nature of things based on empiricalevidence, through learning such as in the natural sciences, social
sciences and humanities. It is only through scientific and empiricallearning, or thinking based on science, that we can create new values,
find solutions to the problems we face and make level-headed decisions.
Research at Keio University is always conducted in Fukuzawa's spirit ofscience.
Currently at Keio University, research activities are conducted extensively andin various forms, including advanced research, multidisciplinary research andinternational collaborative research. Some research activities evolve with adeep, narrow focus, while others evolve broadly and expansively. To
promote the progress of these activities, Keio University has continued to
improve its research environment and support structure, as exemplified by the
stipulation and implementation of a code of conduct, the establishment of acompliance framework, the enhancement of international intellectual
property activities and funding for the development of young researchers.
This Annual Report on Research Activities is intended to promotecollaboration with outside institutions and to bring together new
knowledge for the future generation. It indicates the current status andtrends of the research activities at Keio University as clearly as possible,
providing latest statistical data and information on areas of study. We
hope that you will enjoy reading about the research capabilities of Keio
University, as we strive to pioneer the future in Fukuzawa's spirit ofscience.
Professor Atsushi Seike
President, Keio University

03 Campus Research Centers and Office Organization for
Research Advancement and Research Administration
04 Research Advancement and Support System
04 Organization for Research Advancement and Administration (ORAA)
05 Center for Research Promotion (CRP)
06 Intellectual Property Center (ICP)
07 Keio Advanced Research Centers (KARC)
08 Office of Research Administration
09 Research PICK UP

c

o

n

t

e

n

t

s

11 Introduction of Research Centers
11 Mita Campus

Keio University
Annual Report
onResearch Activities

13 Hiyoshi Campus
15 Yagami Campus
17 Shinanomachi Campus
19 Shonan Fujisawa Campus (SFC)
21 Shiba-Kyoritsu Campus
23 Shin-Kawasaki Town Campus
25 Tsuruoka Town Campus

2009-201027 Introduction to Publicly Funded Research
29 Global COE Program
32 Special Coordination Fund for the Promotion of Science and Technology
34 Core Research for Evolutional Science and Technology
35 Ministry of Education, Culture, Sports, Science and Technology (MEXT)
Grant-in-Aid for Scientific Research

36 Health and Labour Sciences Research Grants
37 Research Funds at Keio University in FY2009
41 Researchers at Keio University in FY2009
43 Intellectual Property and Technology Transfer
44 Awards for Research Activities in FY2009
46 Introduction to the Keio University Research Databases
47 Research-related Facilities and Libraries
48 FY2009 Financial Position
49 Access Information* This publication introduces research activities from 2009 to 2010.
Titles and positions given from page 4 onward are as of April 2009.

Campus Research Centers and Office Organization for Research
Advancement and Research Administration
CampusMita Campus

・Faculty of Letters (Years 2 to 4)
・Faculty of Economics (Years 3 and 4)
・Faculty of Law (Years 3 and 4)
・Faculty of Business and Commerce(Years 3 and 4)
・Graduate School of Letters
・Graduate School of Economics
・Graduate School of Law
・Graduate School of Human Relations
・Graduate School of Business andCommerce
・Law School

Hiyoshi Campus
P.13-14

・Faculty of Letters (Year 1)
・Faculty of Economics (Years 1 and 2)
・Faculty of Law (Years 1 and 2)
・Faculty of Business and Commerce(Years 1 and 2)
・School of Medicine (Year 1)
・Faculty of Science and Technology(Years 1 and 2)
・Faculty of Pharmacy (Year 1)

Office Organization for Research Advancement andResearch Administration

・Institute for Cultural and Linguistic Studies
・Institute for Media and Communications
Research・Institute for Economic and Industrial Studies(Sangyo Kenkyujo)
・Institute of Oriental Classics (Shido Bunko)
・International Center・Teacher Training Center・Fukuzawa Memorial Center for Modern
Japanese Studies
・Keio Institute of East Asian Studies (KIEAS)
・Center for Japanese Studies
・Research Center for the Arts and Arts
Administration
・Global Security Research Institute (G-SEC)
・Research Institute for Digital Media andContent (DMC)

Mita Office of Research
Administration

・Institute of Physical Education
・Sports Medicine Research Center・Health Center・Keio Research Center for Foreign Language
Education
・Keio Research Center for the Liberal Arts
・Research and Education Center for Natural
Sciences・SDM Research Institute・KMD Research InstituteHiyoshi Office of Research
Administration

・Keio Leading-edge Laboratory of Science andTechnology (KLL)

Office of Research
Administration, Yagami Campus

・Center for Integrated Medical Research(Research Park)・Keio Center for Clinical Research・Keio University Hospital

Shinanomachi Office of
Research Administration

・Graduate School of Business
Administration (Keio Business School)・Graduate School of System Design andManagement
・Graduate School of Media Design

Yagami Campus
P.15-16

・Faculty of Science and Technology(Years 3 and 4)
・Graduate School of Science andTechnology

Shinanomachi
Campus
P.17-18

・School of Medicine (Years 2 to 6)
・Faculty of Nursing and Medical Care
(Year 3)・Graduate School of Medicine

P.19-20

・Faculty of Policy Management (Years 1 to 4) ・Keio Research Institute at SFC
・Faculty of Environment and Information
Studies (Years 1 to 4)
・Faculty of Nursing and Medical Care
(Years 1, 2, and 4)

Shonan Fujisawa Office of
Research Administration

・Graduate School of Media and Governance・Graduate School of Health Management

Shiba-Kyoritsu
Campus
P.21-22

・Faculty of Pharmacy
Department of Pharmacy (Years 2 to 6),
Department of Pharmaceutical Sciences(Years 2 to 4)

The Group for Research
Administration, General Affairs
Office, Shiba-Kyoritsu Campus

・Graduate School of Pharmaceutical
Sciences

Shin-Kawasaki
Town Campus

Shin-Kawasaki Town Campus
OfficeP.23-24

Tsuruoka
Town Campus

・Institute for Advanced Biosciences

P.25-26

03 Campus Research Centers and Office Organization for Research Advancement and Research Administration

Tsuruoka Town Campus Office

Head Office of Research Administration P.08

Shonan Fujisawa
CampusOrganization for Research Advancement and Administration (ORAA) P.04

P.11-12

Research Centers (Faculties, Graduate Schools, Institutes, and Others)Organization for Research Advancement
and Administration

http://www.oraa.keio.ac.jp

Research Advancement and Support at Keio University
Keio University believes that its mission of returning the fruits of research tosociety is important. Based on the principle of "Gakujutsu Sendo (leadershipfor scientific progress)," the University aims to make significant contributions
to international society in the 21st century through original and creative
academic research. Keio University promotes numerous advanced research
projects at six campuses: Mita, Hiyoshi, Yagami, Shinanomachi, Shonan
Fujisawa, and Shiba-Kyoritsu. Traditionally, Keio University has been deeply
involved in collaborative activities between industry, government, andacademia. Activities such as commissioned research, joint research, andpersonnel exchanges are mainly undertaken at five research facilities: the Keio
Leading-edge Laboratory of Science and Technology (KLL) at the Yagami
Campus, the Center for Integrated Medical Research at the Shinanomachi
Campus, the Keio Research Institute at SFC (Shonan Fujisawa Campus), theShin-Kawasaki Frontier Research and Education Collaborative Square (K2) in
Kawasaki City, and the Tsuruoka Frontier Research and Education
Collaborative Square in Tsuruoka City.
Keio established the Organization for Research Advancement andAdministration (ORAA) in October 2003 to provide further support for thesewide-ranging research activities undertaken at these facilities, which we
believe should boost the university's ability to create, promote interdisciplinary
studies and return the fruits of research to society.

Offices of Research Administration (p. 8)
Support research activities at all campuses

Keio Advanced Research Centers (KARC) (p. 7)
Supports and promotes the formation of advanced, interdisciplinary research
centers

The campuses of Mita, Hiyoshi, Yagami, Shinanomachi, Shonan Fujisawa, Shiba-Kyoritsu,
Shin-Kawasaki, and Tsuruoka each have an Office of Research Administration. Each officesupports research by maintaining close contact with individual researchers, acts as an oncampus contact point for external organizations, and promotes research collaboration with
ORAA. Specifically, the Offices provide information to researchers in areas such as researchresources, research environments, and opportunities for research subsidies from inside andoutside Keio University (public calls for subsidy applications), and also offers a variety ofother support services including negotiations and the signing of contracts for joint orcommissioned research, management of research expenses and research spaces, andcompilation and presentation of research results.

Center for Keio Frontier
Research and Education
Collaborative Square(K-FRECS) (p. 23, 25)
While the university's main campuses
maintain the traditional functions ofresearch and education, the Frontier
Research and Education Collaborative
Square (K-FRECS) functions as a basefor cutting-edge, collaborative researchbased on cooperation with thecommunity, as well as essential
research that cuts across various
university faculties and graduate
schools.

Center for Integrated
Education System

Shonan Fujisawa Office of Research Administration

Roles and Functions of the ORAAThe ORAA comprises various centers and committees, including: the Center for
Research Promotion (CRP), the Intellectual Property Center (IPC), Keio
Advanced Research Centers (KARC), the Intellectual Property Mediation
Committee, and the Research Ethics Committee. Head Office, Office of
Research Administration is responsible for the administration of eachorganization under the ORAA. Together with the Offices of Research
Administration, the ORAA promotes and supports all aspects of researchrelated activities, from the start of strategic research to the transmission andcontribution of results to society. The major roles and functions of eachorganization in the ORAA are as follows.

The Keio Advanced Research Centers (KARC) flexibly performs activities related to theestablishment, restructuring and/or abolition of the research centers, as well as theoperations of the research centers and their personnel. The research centers function asuniversity-wide organizations that transcend the boundaries of the univeristy faculties andgraduate schools. KARC is an organization that invigorates and accelerates such research
activities. Each research center at KARC uses external funds as the fiscal resources for its
activities. The campuses that are to serve as the centers of these activities are designatedand tasked with research assignments. A center is established over a limited period of time(center formation period). This limit on the period for the formation of centers is expected topromote research results and the development of the research itself, in keeping with thedevelopment of research contents; for example, when a given formation period is complete,
new research centers can be formed to carry on that work, or new organizations can becreated within the university.
Shinanomachi Office of Research Administration
Office of Research Administration, Yagami Campus

General Affairs Office, Shiba-Kyoritsu Campus

Hiyoshi Office of Research Administration
Mita Office of Research Administration
Head Office of Research
Administration
Offices of Research
Administration

Keio Advanced
Research Centers(KARC)

Center for Research
Promotion (CRP)

Intellectual Property
Center (IPC)

The Center for Integrated Education
provides front-line support in the
primary and secondary education
facilities affiliated with Keio University.
Organization for Research Advancement
and Administration (ORAA)

Center for Research Promotion (CRP) (p. 5)
Comprehensively promotes collaboration between industry, government,
and academia
The Center for Research Promotion (CRP) plays the role of a general contact point forplanning and promoting integrated and strategic research efforts based on collaboration
between industry, government, and academia. In addition, the CRP serves as a gateway tocoordinate collaboration between companies, universities, and research institutes in Japanand overseas. The CRP is responsible for advancing interdisciplinary research andcomprehensive research collaboration. Specifically, the CRP advances joint research projects
through discovering and combining university resources that match business needs. It
supports the application process to obtain public funding on research themes together withindustry and the launching of the research themes. The CRP manages university research
grants-in-aid to create and support joint research between industry, government, andacademia. Through symposiums, it also advances exchange and communication of research
results with external organizations. These activities are advanced through discussions with
the CRP Advisory Board, which is commissioned to give advice by the CRP.

Intellectual Property
Mediation Committee
When an inventor lodges an objection
regarding a given patent application,
the Intellectual Property Mediation
Committee acts as a mediator basedon the Keio Univertsity Regulations for
the Handling of Inventories.

Research Ethics Committee
The Research Ethics Committee
coordinates and manages policies andregulations related to issues such as
research ethics and conflicts ofinterest. Its main goal is to create
structures that are capable ofpromoting fairness and safety inresearch activities in response to
demands from society, particularly
with regard to compliance problems in
relation to recent university research
activities, and the conflicts of interest
that can arise in activities involving
collaboration among industry,
government, and academia.

Intellectual Property Center (IPC) (p. 6)
The Technology Licensing Organization (TLO) for Keio University
As Keio University's Technology Licensing Organization (TLO), the Intellectual Property Center(IPC) has a wide range of responsibilities, from management and operation of intellectual
property rights generated by the university to promotion of collaborations with society basedon those intellectual property rights. Based on applications for inventions submitted byresearchers, the IPC closely examines patentability and the potential for licensing, taking into
consideration the researchers' concepts of practical applications. It then makes selections,files patent applications, and maintains and controls those successful patents. These
technology licensing operations open the door to a wide range of other activities, including
licensing of Keio University's patented technologies to companies, the creation of newcompanies with foundations in intellectual property rights, and joint research with companies
aimed at developing products for practical applications.
The IPC also supports and promotes the incubation activities of Keio University overall while
carrying out all the steps, from education and research to return of the fruits of research tosociety, together with each campus and in collaboration with industrial circles.
* The Keio Incubation Center was integrated into the Intellectual Property Center in April 2010.

Organization for Research Advancement and Administration (ORAA)

04

Center for Research Promotion (CRP)

http://www.crp.keio.ac.jp/en/index.html
E-mail: crp@info.keio.ac.jp

Development of collaboration between industry, government,
and academia

The Center for Research Promotion (CRP) functions as a general contact point in the planning and promotion of comprehensive, strategic research(research across faculties and interdisciplinary research) through collaboration between industry, government, and academia, and incollaborations with companies, universities, and research institutes in Japan and overseas. In particular, the CRP is responsible for advancing
interdisciplinary research and comprehensive research collaborations.

1. Collaborations with Outside Institutions

4. Open Symposiums(1) Nippon Telegraph and Telephone Corporation (NTT)Keio University and Nippon Telegraph and Telephone Corporation (NTT) signed acomprehensive partnership agreement in March 2006, and have beensuccessful in increasing the number of individual joint research agreements.
In FY2009, the number of joint research projects stood at 14 and 10 patentapplications were filed, while there were 4 cases of development, including
software development, and 24 external presentations and papers.

Keio University hosted the following five open symposiums in FY2009, withparticular focus on the bioscience and life science fields:(2) RIKEN Japan
Keio University and RIKEN Japan signed a collaboration and cooperationagreement in December 2008, and are continuously engaged in collaborative
activities. The Research Centre for Human Cognition was established byresearchers from both institutes in April 2009 to drive progress in specificcollaboration activities.
Keio and RIKEN Japan held four symposiums in FY2009: "Toward Integrative
Understandings of the Human Intelligence," "Future of Brain, Body and Human
Interface Design," "Toward Sustainable Social Systems," and "Neurobiological
Basis for the Brain Evolution and Mind.""Demonstrative Research on Metabolomics: From the Basis to the Clinic of"Drug Discovery;""Collaborative Seminar by the School of Medicine and the Faculty of Science"and Technology at Keio University;""Food and Medical Science, and Health and Longevity;""Elucidation of the Neural Basis that Produces the Mind;" and"Challenging Cancer - Forefront of Basic and Clinical Research."(3) Itochu Corporation"Next-generation Web service planning/development program 2009" wasimplemented, with Itochu Corporation as its sponsor, targeting students of
Keio University and Waseda University.

2. Acquisition of Public Funds
Project coordinators of CRP, in cooperation with researchers, played a key role inapplying for and obtaining major public funds including A-STEP of the Japan
Science and Technology Agency (JST).

Keynote lecture given at a symposium

3. The External Collaborative Research Creation Fund

5. Other Activities

Under the grant system, nine joint research proposals were selected andimplemented in FY2009, with an emphasis on the novelty of research activities(new research themes, new collaborative partners, and new research teams) andon the social impact of the proposed research, following FY2008.

Keio University also focused its efforts on the environmental field in FY2009.
The university successfully received funding under the "Project to Formulate a
Vision for New Regional Energy and Energy Conservation", sponsored by the New
Energy and Industrial Technology Development Organization (NEDO), and theuniversity's proposal was accepted. Investigations were conducted to verify
the introduction and effective operation of new energy and energy
conservation facilities to enable the Hiyoshi Campus and the Yagami Campus togo green.
In addition, Keio University proceeded with planning the Library of Existing
Drugs of the School of Medicine of Keio University as a project based oncollaboration between industry, government, and academia, and collected
existing drugs (pharmaceuticals whose pharmacology and safety have alreadybeen verified, namely over-the-counter drugs and pharmaceutical lozenges inphase II and phase III clinical trials, etc.) and turned them into a library. Keio plans
to carry out a research in which chemical compounds will be evaluated using thislibrary. The research aims to develop new uses and expand applications(mainly anticancer agents of these chemical compounds) at the School of
Medicine.

05 Center for Research Promotion

Intellectual Property Center (IPC)

http://www.ipc.keio.ac.jp/english/
E-mail: toiawasesaki-ipc@adst.keio.ac.jp

Intellectual property rights and technology transfer

The transfer of technologies from universities to the industrial world began with the enactment of the "Act on the Promotion of Technology Transfer from
Universities to Private Business Operators" in August 1998. Keio University established the Intellectual Property Center (IPC) in November 1998, and has
worked actively towards returning the benefits of research created by the university as an authorized Technology Licensing Organization (TLO) to society
in the form of products and technologies.
The IPC, which absorbed the Keio Incubation Center in April 2010, aims to create social and economic values by collaborating with each campus andsupporting venture companies originating from Keio University in cooperation with the industrial circles.

1. Promoting Technology Transfer Activities
The IPC returns benefits of research results at Keio University to society by turning research results created by researchers in various faculties and graduate
schools on Keio University's campuses into industrial property rights and transferring them to industrial circles. Technology transfers are conducted in three forms: (1)licensing to companies; (2) commissioned/joint research with companies based on Keio University's intellectual property; and (3) the creation of venturecompanies.

2. Creating a Venue for Information Exchanges between Industry, Government, and Academia
The "Leading Innovation Network," a series of gatherings to introduce technologies aimed at transferring research results from Keio University to industry in the formof concrete technologies, was held twice in FY2009.
The Venture Private Conference, including presentations by venture business managers on business strategies and the outlook for the future, as well as theintroduction of specific businesses, was also held in FY2009.

3. Intellectual Property Center Awards / Education
The 10th Intellectual Property Center Award, in FY2009, was presented to Professor Kunihiro Takahashi, Faculty of Science and Technology, for the project entitled, "ThePathway Analyzer Based on the Load Transfer Pathway Method." A lecture course entitled, "On the General Theory of Intellectual Property", is run by theIntellectual Property Center using the Nateglinide Memorial Toyoshima Research and Education Fund (an internal grant-in-aid program). This course, implemented forthe students of all faculties, provides educational opportunities in relation to intellectual property.

4. Developing Industry-Government-Academia Collaboration Strategies
In FY2009, various actitivities were undertaken in the following two fields as part of Industry-Government-Academia Collaboration Strategy Development program by
the Ministry of Education, Culture, Sports, Science and Technology (MEXT): "Promoting international Industry-Government-Academia Collaboration activities" and "Building
Intellectual Property Portfolio Formation Model."Activities included:(1) Establishing international intellectual property strategies and methods for international research development, and carrying out investigations / analysis into
technological trends regarding model themes;(2) Holding an international forum with a focus on U.S. bioscience-related venture businesses and an international symposium under the theme of regenerative
medicine;(3) Holding an international workshop to transmit information on the establishment of venture businesses concerning fledgling ideas with 27 Asian universities,
making the most of the SOI Asia Network;(4) Creation of an introductory tool for overseas corporations by visualizing fledgling ideas for research patent, as an international technology transfer method; and(5) Preparation and analysis of an intellectual map concerning joint research themes with the National Institute of Advanced Industrial Science and Technology and
RIKEN Japan.
Conceptual Framework of Incubation at Keio University
Keio University IPC Activities
Objective: Develop "research results" for business application
Through the transfer ofintellectual property andtechnology

Expand and broaden the research efforts of
Keio University
Invigorate the University environment

Keio University
Research
Contract

Research

Education

Knowledge
Manpower

IndustryAward

Opportunities for
Exchange

LicenseApprovalCompany
Start-ups

Research

Academia: Research

Joint
Research

Industry also
participates in learningand researchIntegration ofIndustry andAcademia

Data
Fund
LearningIndustry:
Practical Applications

PatentProtection

Technology
Transfer

Follow UpIntellectual Property Center

Traditional division of
responsibilities

Academics has a
responsibility topractical applications

Practical
Applications

Ideal form of collaboration
between industry and academia• Integrated IP/technology transfer system• A comprehensive program that includes
support for research contract, venture
start-ups, and information exchange

Center for Research Promotion 06

Keio Advanced Research Centers (KARC)

http://www.karc.keio.ac.jp/index.html
E-mail: karc-jimu@adst.keio.ac.jp

Supporting revitalization of advanced, interdisciplinary research activities

Keio University established the Keio Advanced Research Centers (KARC) in February, 2007, in response to an increasing number of requests to form new types of research
centers (or education and research centers) that merge and connect a wide range of research fields. KARC aims to further revitalize research activities by flexibly performing
activities related to the establishment, restructuring and/or abolition of the research centers, as well as the operations of the research centers and their personnel. The
research centers function as university-wide organizations that transcend the boundaries of the University faculties and graduate schools. The research centers use
external funds as resources for activities, and undertake these activities by designating campuses that serve as centers for these activities. As a rule, the Centers are
established over a period of five years (Center formation period), but this period can be extended to 10 years if conditions, including funds, are met. This limit on the
period for the formation of the Centers is expected to promote research results and the development of the research itself, in keeping with the development of the researchcontents; for example, when a given formation period is complete, new research centers can be formed to carry on that work, or new organizations can be created within
the university.
One Center Director is appointed at each Center, and the Director of KARC, supervises all Centers.

1. Unique Features of KARC
Thirty-four Centers were created after the establishment of KARC. Eight of these Centers
have already completed their activities. The following are some of the unique features of
KARC:

Organizational
Structure of KARC

• Forms advanced, strategic research centers at Keio University;• Proposes and develops new domains, including fusion areas, that are not restrained byframeworks of existing academic disciplines;• Has an organizational structure that is capable of handling dynamic research projects; and• Closes research centers immediately after they complete their missions.
KARC has also introduced a unique system called the "Starting Up Center" (SU). This is apreparatory center for research groups with clear academic objectives and concrete plans. It isutilized to set up a more formal research center later. The four new Centers set up in FY2009 were
established under this scheme.

Intellectual Property
CenterA Center (Research Center)

Organization for
Research Advancement
and Administration(ORAA)

Keio Advanced
Research Centers(KARC)

Center for Research
Promotion

B Center (Education andResearch Center)

C Center (Research Center)

2. The Mission of KARC
KARC is an interface for a wide range of centers that are representative of Keio University. It operates these centers in a wide range of formats, including Global Centers of Excellence
and centers funded by Japanese public funds (such as the Special Coordination Fund for the Promotion of Science and Technology), as well as EU Centers of Excellence and centers
undertaking joint research with private corporations. Campuses hosting such research centers can be found on virtually all of Keio University's campuses: Mita, Hiyoshi, Yagami,
Shinanomachi, Shonan Fujisawa, and Shin-Kawasaki.
KARC seeks to utilize the unique characteristics of the centers' respective faculties and campuses and merge those characteristics to create new frameworks for and approaches tocarrying out research at Keio University.

Centers within KARC (as of May 1, 2010)
PeriodResearch BaseIntroduction of
Research

Professor, Graduate School of Medicine

2007/02/01〜2012/03/31

Shinanomachi

P.29

Professor, Graduate School of Science and Technology

2007/02/01〜2012/03/31

Yagami

P.29

Shigeru Watanabe

Professor, Graduate School of Human Relations

2007/02/01〜2012/03/31

Mita

P.30

The Center for Civil Society with Comparative Perspective (CCC)

Yoshiaki Kobayashi

Professor, Graduate School of Law

2007/04/01〜2012/03/31

Mita

Center for Integrative Mathematical Sciences (CIMS)

Yoshiaki Maeda

Professor, Graduate School of Science and Technology

2007/05/01〜2011/03/31

Yagami

GSP Center (Center for Genome Super Power)

Jun Kudo

Professor, School of Medicine

2007/06/01〜2012/05/31

Shinanomachi

Co-Mobility Society Research Center

Ikuyo Kaneko

Professor, Graduate School of Media and Governance2007/07/01〜2015/03/31

Shin-Kawasaki

Market Quality Research Center at Keio University

Eiji Hosoda

Professor, Faculty of Economics

2007/09/01〜2012/03/31

Mita

P.31

Panel Data Research Center at Keio University

Yoshio Higuchi

Professor, Faculty of Business and Commerce

2007/09/01〜2012/03/31

Mita

P.31

Keio Jean Monnet COE Centre for EU Studies

Katsuhiro Shoji

Professor, Law School

2007/09/01〜2012/08/31

Mita

Education and Research Center for Stem Cell Medicine

Hideyuki Okano

Professor, School of Medicine

2008/01/01〜2012/12/31

Shinanomachi

Research Center for Life-Conjugated Chemistry

Koji Suzuki

Professor, Faculty of Science and Technology

2008/03/01〜2011/03/31

YagamiCenter of Governance for Civil Society

Yoshihisa Hagiwara

Professor, Faculty of Law

2008/03/01〜2013/03/31

Mita

P.32

Work-Life Balance Research Center

Kikuko Ota

Professor, Faculty of Nursing and Medical Care

2008/07/01〜2011/03/31

Shonan Fujisawa

P.32

Center for Education and Research of Symbiotic, Safe and Secure System Design

Takashi Maeno

Professor, Graduate School of System Design and Management

2008/07/01〜2013/03/31

Yagami/Hiyoshi

P.31

Career Development Center -Medical and Life Science-

Toshio Suda

Professor, School of Medicine

2008/07/01〜2013/03/31

Shinanomachi

P.33

Center for Advanced Light-Wave Control Technologies

Fumihiko Kannari

Professor, Faculty of Science and Technology

2008/08/15〜2013/07/14

YagamiThe Twin Research Center for Behavioral Development

Juko Ando

Professor, Faculty of Letters2008/09/01〜2013/03/31

Mita

Collaborative Innovation Center for Cutting-Edge Life Science Research

Nobuhide Doi

Associate Professor, Faculty of Science and Technology

2009/01/01〜2014/03/31

YagamiKeio-Med Open Access Facility

Hideyuki Okano

Professor, School of Medicine

2009/02/01〜2013/03/31

Shinanomachi

Spintronic Research Center

Kohei Ito

Professor, Faculty of Science and Technology

2009/03/01〜2012/03/31

Yagami

Nursing Best Practice Center (SU)*Yuko Takeda

Professor, Faculty of Nursing and Medical Care

2009/03/01〜2011/02/28

Shinanomachi/Shonan Fujisawa

Research Centre of Human Cognition (SU)*Shigeru Watanabe

Professor, Faculty of Letters2009/04/01〜2011/03/31

Mita

Global Center for Learning Science and Technology (SU)*Keiko Okawa

Professor, Graduate School of Media Design

2009/04/01〜2011/03/31

Mita

Center for Energy and Environment (SU)*Yoko Wake

Professor, Faculty of Business and Commerce

2009/04/30〜2011/03/31

Mita

Negotiation Research Center (SU)*Jiro Tamura

Professor, Faculty of Law

2009/06/01〜2011/03/31

Mita

Center Name

Center Director

Center for Human Metabolomic Systems Biology

Makoto Suematsu

International Center of High-Level Global Cooperation for Leading-Edge Platform on Access Spaces

Kouhei Ohnishi

Centre for Advanced Research on Logic and Sensibility*SU stands for "Start Up Center."

07 Intellectual Property Center

P.30

P.35

Office of Research Administration

http://www.ora.keio.ac.jp
E-mail: ora-honbu@adst.keio.ac.jp

Striving to support the development of research activities

The Office of Research Administration (ORA) was established in 1999 as an administrative department to provide direct support for researchers affiliatedwith Keio University. In addition to the Head Office, each of its offices is located on the Mita, Hiyoshi, Yagami, Shinanomachi and Shonan Fujisawa
Campuses. Today, a total of eight offices, including those on the Shin-Kawasaki, Tsuruoka and Shiba-Kyoritsu Campuses, and the Head Officecollaborate with each to enhance research activities inside and outside Keio University by offering flexible and appropriate administrative support foreach of the rapidly diversifying and advancing internal and external research projects.

1. Administrative Support for Collaborative Projects among Industry, Government, and Academia
In recent years at Keio University, collaborative projects among industry, government and academia have been steadily growing, both in terms of the number of projects and in therate at which they are being acquired. These projects represent unconventional proposals and combinations between campus-wide fledgling ideas for research/technology
discovered from an interdisciplinary perspective and the needs of external organizations. The promotion of these projects involves ORA on each campus acting as a liaison from CRP
to support the researchers engaged in these projects and to contribute to the realization of high-quality research activities.
Representative research support services•Collection of information on research aids, provision of related data to researchers•Liaison among related internal and external divisions•Support for application and report processes•Overall project management(Progress management, research expense management, and negotiation and completion of contract/service agreement on research, etc.)•Support for the presentation of achievements and public relations

2. Administrative Support for Research Projects Initiated on Each Campus
Numerous innovative research projects have been developed on each campus at Keio University. Various forms of research and personnel exchanges in each field are currently undertaken
actively at such organizations as the Keio Leading-edge Laboratory of Science and Technology (KLL) on the Yagami Campus, the Center for Integrated Medical Research on the
Shinanomachi Campus, the Keio Research Institute at SFC on the Shonan Fujisawa Campus, Frontier Research and Education Collaborative Square (K-FRECS) - Shin-Kawasaki in Kawasaki
City, and the Institute for Advanced Biosciences in Tsuruoka City. Each ORA plays a role in supporting the operations at the research institutes and engages in a diverse range of activities,
including setting up the concept of the research structure at each campus, the mediation of agreements on outsourcing and joint studies, negotiation/completion processes, the process
for appointing research staff, public relations/publication activities (such as the introduction of researches/researchers, study results), control of the research expenses/facilities andevent management.

3. Application Process/Management of Public Research Funds and Arrangement of University Research Grant-in-aid Programs
The Head Office, serving the central function of ORA, supervises large-scalecompetitive funds and Matching Fund Subsidy for Private Universities (special aid),such as the Global COE Program, Grant-in-Aid for Scientific Research (KAKENHI),MEXT and Special Coordination Funds for Promoting Science and Technology, fromthe application process to the reporting of study results and accounting incollaboration with each ORA. The supervising activities include a "complianceapproach." With social interest in the appropriate use and management of researchexpenses at research institutions increasing every year, ORA provides researchers and therelated administrative departments in Keio University with a research expense manual andtraining activities in the form of workshops.
Keio University also has many special grant-in-aid programs financed from university funds
as well as a budget for running expenses. The University facilitates researchers inmaking effective use of the funds for their own research activities. The Head Office alsosupervises the management of these university grant-in-aid programs. In addition to these
programs, the Head Office handles applications from public foundations and manages a
researcher information database.

Example of administrative process guidelines issued by the Head Office, ORA("Special Research Fund Manual" and "Research Handbook")

Incubation Center 08

Research PICK UP
Formation of the Basis of Worldwide Comparative Researchon Illustrated Books in the 15th to 17th Centuries
Toru Ishikawa
Professor, Faculty of Letters
I have been involved in a project that undertakes worldwide comparative research ofillustrated books that have been created in various countries and regions mainly during theAge of Discovery (the 15th to 17th centuries), when countries came to establish mutual
relationships. This project, the "Formation of the Basis of Worldwide Comparative Research on
Illustrated Books in the 15th to 17th Centuries" (popular name: Illustrated Book Project;abbreviation: EIRI), is a project for MEXT in order to support the formation of strategic researchbases at private universities.
During the Age of Discovery, many beautiful hand-made picture books, called Nara Ehon (Narapicture books), and illustrated scrolls were made in Japan. Even though countries around the world
possess Nara Ehon and illustrated scrolls as cultural assets that are symbolic of Japan, they have
unfortunately never been the subject of comprehensive research. As they are very beautiful
and their themes are centered on works of classical literature, they are now often included in juniorand senior high school colored textbooks. Most examples of Nara Ehon and the illustrated
scrolls were not autographed, so the identity of the people who created them and the time they
were created has been lost. However, advances in the digitalization of such works have finallymanaged to elucidate their production process. Under the Illustrated Book Project, we
prepared a catalogue of the locations of Nara Ehon and illustrated scrolls, purchased works thatare valuable as materials, and then pursued various types of research. We also engaged inpublicity activities through international symposiums and lecture meetings.
Various illustrated books were also made in the West during this age following thewidespread introduction of printed books that started with the Gutenberg Bible. As part of the
project, we run workshops and attend international symposiums after researching andcollecting early printed books, called incunabula, and illustrated books, called the Book of
Hours. In addition, we collect information and conduct research on fortunetelling books from thisage, which have expanded globally. As you can see, our aim is to conduct worldwide
comparative research based on comparative research on illustrated books in East Asian
countries, while centering on Japan, China, and Korea. Our comparative research also includes
illustrated books in Western nations as well as Islamic and Indian illustrated books.
Although we are still in the early stages of our research, various aspects have emerged from a

global standpoint, including the similarities between the Nara Ehon of Japan and theminiatures of the Islamic and Indian world, as well as the similarities between the coloring of theearly printed books of Japan, called Tanrokubon, printed books from the Ming era of China andearly printed books in the West. We intend to verify whether these similarities are the result ofphysical limitations in the Age of Discovery.
The digitalization of books is indispensable in verifying these hypotheses. As part of thisproject, we are digitalizing various illustrated books so that we will be able to compare them withother illustrated books from around the world. The valuable books purchased and theinformation obtained under this project will be stored in the Keio University Library, while the digitalequipment purchased, together with the relevant technologies, will be taken over by the
research centers affiliated with Keio University.
Relevant URL: http://dbs.humi.keio.ac.jp/naraehon/

Illustrated book on Urashima TaroThe Development and Evaluation of Training Programs for Improving
Risk/Crisis Communication Skills of Health Crises Management Personnel
Toshiko Kikkawa
Associate Professor, Faculty of Business and Commerce
The outbreak of the H1N1 pandemic in 2009 had an enormous impact on society. Many people
have realized that the effects of the pandemic could increase unexpectedly, depending on how
information is conveyed.
In times of various health crises, including infectious diseases, the outbreak of large-scale
food poisoning and other disasters, the communication capabilities of the people handling thecrises become important. However, no systematic training programs to develop these skills
and capabilities are currently available.
Against this backdrop, our group is actively engaged in research aimed at developing andmaking widely available training programs for the staff working in the crisis management
divisions of local governments and the Ministry of Health, Labour and Welfare. In 2009, the firstyear of the three-year research project, we collected relevant training programs from a wide rangeof sources at home and abroad, and analyzed them. We also launched several provisional
training programs.
Following is the brief introduction into our two major training programs. One was held at Keio
University as a two-day session on September 26-27, 2009. First, Mitsuo Uehara, DirectorGeneral of Crisis Management, Yokohama City, and Kazuyuki Nakagawa of Jiji Press gave
lectures on the frontline system for handling the H1N1 pandemic in 2009. Following thelectures, participants shared their experiences of responding to the pandemic and identified
problems. Then, training was conducted under the theme, "the importance of flexibility incrises." As part of the program, we invited two researchers from the National Center for Crisis
Management Research and Training (CRISMART) at the Swedish National Defense College.
Together, we have worked in such areas as staff exchange and evaluation of training courses basedon detailed analyses of the training.
The other program, designed to teach the basics of communication, was held at the Ministry of
Health, Labour and Welfare. We held a series of six training sessions over about half a year. We
could continue training interactively in a relaxed but serious atmosphere, effectively using
educational tools such as blocks. Based on this training program, we published a brochure
entitled, "The First Step in Communication," and released it to the public.
This research group is comprised of researchers, including Professor Fumitoshi Kato of the09

Faculty of Environment and Information Studies and researchers from the Aichi University of
Education, Ryutsu Keizai University, and Sanno University. Researchers from the National
Institute of Infectious Diseases and Juntendo University are also taking part in the team toengage in study from a medical standpoint. In addition, we have also solicited local
government officials and journalists to cooperate with us in evaluating the training.
As the leader of the research project, I am confident that I have appointed suitable people to theresearch group. I am sure that our research will help in improving the qualities of health crisis
managers and indirectly help in reducing the social impact of health crises.

Training session held at the Ministry of Health, Labour and Welfare

Research PICK UP
Research and Development of Photonics Polymers Toward theCreation of a Face-to-Face Communication Industry
Yasuhiro Koike
Director of the Keio Photonics Research Institute (KPRI) / Professor, Faculty of Science and Technology and Graduate School of Science and Technology
A program entitled "Research and Development of Photonics Polymers toward the Creation of aFace-to-Face Communication Industry" was adopted for funding by the Funding Program forWorld-Leading Innovative R&D on Science and Technology (FIRST) of the Cabinet Office inFY2009. The Keio Photonics Research Institute was established at the Faculty of Science andTechnology and the Graduate School of Science and Technology of Keio University, marking theformal start of the research.
Two decades ago, I stood at a crossroad in my research: I pondered whether it is possible to createhigh-speed plastic optical fiber (POF) that could transmit optical signals at a speed of one
gigabit per second or more. The POF made as a trial was not very transparent, and it
transmitted light for only six meters. To obtain a transmission speed of one gigabit per second or
more, it was necessary to form a refractive index distribution by adding another material(dopant) to the inside of the fiber in order to create a density distribution in the radial direction.
However, a major issue at that time was how to eliminate impurities in order to make the POF
transparent. It was a great challenge to achieve high-speed optical communication by adding
dopants (impurities?) to form a refractive index distribution, which was contrary to the ideas
prevailing at that time.
When I started focusing on elucidating the origin of light scattering in an effort to reduce theamount of light lost due to scattering in the optical polymer, researchers had observed lightscattering in the polymer that exceeded the theoretical explanation. Since it was not possible toreduce this light scattering, there was a vague idea that light scattering is a feature of opticalpolymer. However, detailed and basic research into the light scattering had not been fully
conducted on a global scale. Under these circumstances, I pursued detailed theoretical andexperimental analysis. I demonstrated that the various speculations were false, and proposed a
new light scattering polymer model [1]. The views at that time concerning the origin of lightscattering caused a dramatic advance in the research and development of graded-index
polymer optical fiber (GI-POF). In an experiment in 2009, we successfully achieved atransmission speed of over 40 gigabits per second over a distance of 100 meters for the first timein the world. The success marked the instance when the transmission speed of GI-POF
exceeded that of GI-type glass optical fiber.
The Internet has drastically changed our lives. However, the more convenient it becomes, the moredifficult it seems to avoid using small displays and keyboards. Even the elderly are forced to use
such keyboards. On the other hand, if face-to-face communication technology, which features

realistic video images created by large, life-sized displays withsuperior picture quality, becomes possible, parents whoare confined to nursing homes will be able to experience thewarmth of face-to-face communication through the GI-POF
display, feeling as if they were near their children who are in distant locations. This is adifferent world that cannot be achieved by pursuing the current culture of small displays andkeyboards. Face-to-face communication technology requires displays and terminals to beconnected to a high-speed network that can transmit data faster than one gigabit per second. The
key innovation to that end is photonics. We have introduced and are promoting a concept
called "Fiber-to-the-Display," which uses photonics polymer technology. Under this technology, GIPOF is directly connected to displays. We are targeting human-compatible innovation, whereby
technology is designed to be compatible with humans instead of forcing people to becompatible with technology that is based on the keyboard.
[1] Macromolecules, 25, pp4807-4815 (1992)

Access to a new world through Fiber-to-the-Display
Medical

Education

GI-POF:
Graded-index plastic
optical fiber
Optical fibers connectedto the interior of a house

Eco & Security

Entertainment

Breakthrough in Bioscience by Bringing Together Medicine,
Pharmacology, Science, Technology and Agriculture
Masaru Tomita
Director, Institute for Advanced Biosciences / Professor, Faculty of Environment and Information Studies
Cells that form the basis of life are so complicated that it is thought absolutely impossible tounderstand them in their entirety. We took up the challenge of disproving this view head-on throughthe use of IT (Information Technology), and in 1997, we succeeded in reproducing a virtual cell (anE-Cell) on a computer for the first time in the world [1].
In 2001, the Institute for Advance Biosciences was established in Tsuruoka, Yamagata
Prefecture, where we developed the ultimate in analytical technology to comprehensively
measure cellular conponents. We made optimum use of these technologies in conducting athorough analysis of intracellular components of bacteria, which are unicellular organisms. We
obtained a large amount of data, which was described in Science as "cell data of one of the largest
studies in the world." The publication was highlighted at the beginning of the journal in
Perspectives.[2].
We have coined the term, "data-driven biology," to refer to understanding biological processes froman enormous amount of comprehensively analyzed biological data. "Data-driven biology" has thepotential to bring about a major reform in the framework of bioscience and produce
breakthroughs in various fields.
By conducting a thorough analysis and by comparing cancer cells and normal cells, we
discovered that cancer cells have a special energy metabolism that enables them to survive evenwhen there is insufficient oxygen and nutrients are depleted. Since this special metabolism is very
similar to that of parasitic roundworms, we opened a new avenue in the treatment of cancer using"vermifuges" [3].
We are also researching the practical use of an "ultimate blood diagnosis" to detect diseases at
an early stage by thoroughly analyzing components in human blood. We have been studying
methods of diagnosing various kinds of cancer, Alzheimer's disease, psychiatric diseases such as
depression, hepatitis, nephritis and other conditions by blood analysis. We have also
developed a method for detecting throat cancer, breast cancer and pancreatic cancer fromsaliva [4].
In the environmental field, we are researching oil-producing algae, unicellular organisms thattransform carbon dioxide in the air into oil through photosynthesis in the presence of water andlight. In a sense, it is the ultimate eco-friendly microorganism. To make the algae synthesize oilmore efficiently, we are conducting a thorough analysis under various conditions with the aim of
putting it into practical use.
In addition, we developed a technology that artificially mass-produces spider's silk, which is called"dream fiber" using microorganisms. The material is strong, lightweight, highly heat resistant andbiodegradable, and the manufacturing process is not dependent on petroleum. Using thistechnology, graduate school students launched the bio-venture start-up, "Spiber Inc.," which won
the highest award at the 9th Bio-technology Business Competition Japan.
When we engage in completely original research, we need to make full use of every
technology and area of knowledge, free of the boundaries of academic fields. After all,academic fields have been defined as a matter of convenience by humans. They sometimes impede
free, creative thinking. Young students, who can think freely and without inhibition, without being
swayed by fixed ideas, play a leading role in our research projects. The means of establishing a
research environment in which students can play an active, starring role is the secret of the successof state-of-the-art research. I believe that creating such an environment provides the ideal
education for cultivating human resources that will enable us to improve the future.
[1] Tomita et al. Bioinformatics 15 (1): pp72-84 (1999) Explanatory article: Science 284 (5411): pp80-81 (1999)[2] Ishii et al. Science 316 (5824): pp593-597 (2007)[3] Hirayama et al. Cancer Res. 69 (11): pp4918-4925 (2009)[4] Sugimoto et al. Metabolomics. 6 (1): pp78-95 (2010)

Research on algae that produce oil

10Mita Campus

Research Centers

For Inquiries:

Mita Campus
Pathways to the Future for the
Humanities, Social Sciences, andNatural Sciences: Centers forComprehensive Research and
Education

Mita Campus
2-15-45 Mita, Minato-ku, Tokyo,108-8345 Japan
TEL: +81-3-5427-1517

The Mita Campus is home to undergraduate departments (primarily for third- and fourth-year students), six graduate schools, and independent
research institutions. Following is the introduction into the recent status of activities at research facilities at the Mita Campus.

Research Institute for Digital Media and Content (DMC Institute) http://www.dmc.keio.ac.jp/en/
The Research Institute for Digital Media and Content (DMC Institute) is funded by the "Strategic Research Center Development
Program Special Coordination Funds for Promoting Science and Technology" in 2006 through 2008. As a research center, it has worked
on reforming university system produce research outputs. Also, the DMC Institute has worked on various research activities in digital
media technologies and digital content creation. Institute's activity is evaluated and it has received the highest evaluation "A" from
MEXT. In FY2009, the Institute pursued possibilities of advanced digital media content through many activities, such as special showingof Takigi Noh (torchlight noh performance) archive films at celebration of 150th anniversary of the founding of Keio University, HD
relay broadcasting of a total solar eclipse over the Internet, and joint research with companies.
To accelerate the research activities, DMC Institute made a structure change in April 2010.
Film presentation celebrating Takigi Noh "Tsuchigumo" (Ground Spider)

Global Security Research Institute (G-SEC)

http://www.gsec.keio.ac.jp/index_e.html

The G-SEC carries out research on the global affairs with an emphasis on "watching and warning." In other words, the Instituteconstantly keeps watch on problems in various fields and transmits the necessary warnings. Based on this notion, the Instituteparticipates in industry-government-academia collaborations with an eye toward providing policy advice and creating objective
evaluations, while at the same time carrying out our research activities. The goal is to contribute to the sustained development ofsociety.
In FY2009, the Institute held conference in November and "Watch and Warning" seminars, published newsletters, andconducted multiple projects. The Institute also set up an endowed course and held an open lecture jointly with Minato Ward.
The 3rd G-SEC Conference

Research Center for the Arts and Arts Administration (RCAAA, Keio)

http://www.art-c.keio.ac.jp/en/

The Research Center for the Arts and Arts Administration at Keio University pursues research in areas including the fine arts,
architecture, music, literature, theater, cinema, and dance, as well as cultural appreciation of these areas in contemporarysociety from a holistic and academic stance. In cooperation with experts inside and outside Keio University, the Center develops andcarries out activities that transcend multiple domains, such as seminars, lectures, exhibitions, performances, workshops, case studies
for art management, construction of art archives, and commissioned projects.
Events in FY2009 included a Butoh performance, a video symposium, a project commissioned by Minato Ward, and a course endowedby the Recording Industry Association of Japan. The Research Center was also commissioned to work on a project concerning theformation of joint use/joint research bases by MEXT. The results of the research are also published and disclosed in various
publications.
Publications: "Annual Report (2008/09)" No. 16; "ARTLET" No. 32 & 33; "BOOKLET" No.18

Center for Japanese Studies http://www.ic.keio.ac.jp/nncenter/
The Center for Japanese Studies offers Japanese language and Japanese studies courses tointernational students. In addition, research into practical techniques for teaching Japanese as asecond language and the theory behind those techniques is carried out for the education andtraining of the next generation of Japanese language teachers.
Japanese classes are provided by the Center to first-andsecond-year students enrolled at the Hiyoshi Campus andinternational students belonging to the Graduate School of
Science and Technology, as well as to 192 international
students from 30 countries and regions enrolled in theJapanese Language Program.
In FY2009, reflecting the increase in the number ofinternational students, the Center opened a beginners'
course in Japanese at the Hiyoshi Campus for students
enrolled in the Keio International Program (KIP), international
students belonging to graduate schools, and researchers.
The Center Published: Nihongo to Nihongo Kyoiku No. 38
Nihongo to Nihongo Kyoiku No. 38(Japanese and Japanese Language Education, March 31,(Japanese and Japanese Language2010).
Education)"Concert," cosponsored by
Minato Ward and RCAAA(November 28, 2009)

The Keio Institute of East Asian Studies (KIEAS) http://www.kieas.keio.ac.jp/english/index.html
In FY2009, the Keio Institute of East Asian Studies (KIEAS) established the Center forContemporary Korea Studies (Director: Masao Okonogi), following the establishment of theCenter for Contemporary China Studies (Director: Ryosei Kokubun) in 2007, to further enhance its
research on East Asia, centering on Japan, China and Korea. KIEAS actively carried out
interdisciplinary, international research activities in FY2009 as well. KIEAS implemented
academic projects (four projects underway), which have been launched successfully on anannual basis since 1985, supported by the Takahashi Industrial and Economic Research
Foundation. KIEAS has also been participating in the "Fellows Program on Peace, Governance, andDevelopment in East Asia" organized by the East Asia Institute in Seoul, which targets mid-standing
researchers in the U.S. It also planned andoperated numerous study meetings, and theJapan-Korea Millennium Forum (held at
Korea University in FY2009), centering on
the session of the Presidents of fourJapanese and Korean private universities:
Keio University, Waseda University, Yonsei
University, and Korea University.
Symposium "Revisiting Japan as a normal counrty " (December
15, 2009)

11 Mita Campus

Mita Campus
Fukuzawa Memorial Center for Modern Japanese Studies

http://www.fmc.keio.ac.jp/fmc/eng.html

With the establishment of a new grant-in-aid research program within the Keio Gijuku Koizumi Memorial Fund for the
Advancement of Education and Research, the Fukuzawa Memorial Center for Modern Japanese Studies launched a joint
research, represented by a full-time staff member, and successfully published a collection of letters written by Shinzo Koizumi. With
regard to education, seven courses to the students were held at Mita and Hiyoshi Campuses, and the second series of lecture course
to the public were held at the Keio Osaka Riverside Campus.
It also held two lecture meetings and a symposium entitled, "What is Family?" The Center played a leading role in organizing twoof Keio University's 150th anniversary events: the "Fukuzawa Yukichi: Living the Future" exhibit (a traveling exhibit held in Tokyo,
Fukuoka and Osaka) and "Fukuzawa Yukichi and Kanagawa." It also worked on compiling "An Encyclopedia of Yukichi
Fukuzawa", which is scheduled to be published in 2010.
Publications: "Bulletin of Modern Japanese Studies" No. 26 (2009); "Newsletter of Fukuzawa Memorial Center for Modern
Japanese Studies, Keio University" No. 11 & 12; "Letters of Shinzo Koizumi: 114 letters in total to Shigeo Iwanami and Isamu
Kobayashi" (The Fukuzawa Memorial Center Documents Series Related to Modern Japan: 9); and "Answer Sheets for thecompositions by Harue Okuyama" (The Fukuzawa Memorial Center Documents Series Related to Fukuzawa Yukichi and Keio Gijuku:
12)

Lecture meeting held in the spring semester by the Fukuzawa Memorial Center
for Modern Japanese Studies (June, 2009)

Teacher Training Center http://www.ttc.keio.ac.jp/
The Teacher Training Center, established in December 1982 as a university-wide organization for training instructors, has turned out many outstanding teachers. A Director, Deputy Director and sevenfull-time instructors are engaged in research related to education and the teaching profession. In FY2009, the Center focused on education and research activities aimed at further enhancement of the"Teacher Logbook," a Web system developed through the MEXT Teacher Training "Good Practice" Project. To motivate students to become teachers, the Center also held a forum, "Speaking with youngteachers," as in the previous fiscal year. Furthermore, it developed activities opened to both inside and outside Keio University: the launch of a course in the renewal of teachers' licenses (required, elective)
and the implementation of open study meetings and training for teachers in Minato Ward.

International Center

http://www.ic.keio.ac.jp/en/index.html

The International Center is at the core of Keio University's international activities. It is responsible for sending numerous students and scholars abroad every year, as well as welcoming those coming
to the University. The Center provides support to international students on both academic and lifestyle matters, and is also in charge of exchange programs. For that purpose, it holds overseas study
fairs and information sessions on studying abroad in general, and also provides information on exchange programs. There are also International Studies and Japanese Studies courses in which bothoverseas and Japanese students can study subjects such as the culture, history, politics, and economics of Japan and other countries in English, to promote mutual understanding of different cultures
and to strengthen exchanges between Japanese and foreign students. (In FY2009, a total of 104 subjects were launched.) The Center also implemented six overseas short-term research programs in
FY2009 (summer course at Downing College at the University of Cambridge; summer course at the College of William and Mary; summer course at University of Washington; summer course at Lincoln
College of the University of Oxford; spring course at Institut d' Études Politiques de Paris (Sciences Po); and spring course at Yonsei University).

Shido Bunko, Institute of Oriental Classics

http://www.sido.keio.ac.jp/

The Institute of Oriental Classics or "Shido Bunko" is an institute with a Director, six full-time instructors, and six part-time
instructors. Its mission is to conduct bibliographical research related to Japanese and Chinese literature. During FY2009, it
welcomed Akihiko Niimi, Associate Professor of Notre Dame Seishin University, to the 23rd Shido Bunko Lecture Meeting,where he gave a presentation entitled, "Computer Unitization in the Classification of Various Books - Potential and Challenges." The
Institute also exhibited the " Shido Bunko Storage: Century Cultural Foundation Collection" at the Mita Library of Keio University from
November 24 to December 4. Publications in FY2009 included,"Bulletin of the Shido Bunko Institute" No. 44 (February 26, 2010).

Century Cultural Foundation Collection exhibit (November 24 to December 4, 2009)

Keio Economic Observatory

http://www.sanken.keio.ac.jp/index_e.html

The Keio Economic Observatory (KEO) was set up as an affiliated institute in 1959, as part of the commemoration of the 100th anniversary of the founding of Keio University. Since then, it has conducted
academic research in the three fields of Economics, Law, and Behavioral Science. The membership consists of full-time members of the Institute, members from related faculties, and coresearchers from Japan and overseas. Currently, projects include the construction and analysis of databases on subjects such as input-output analysis, the environment, and flow-of-funds analysis; thehistory of labor-management relations; a proposal for applying the Antitrust Law to public utilities; and environmental and social assessments of solar powered satellites (SPS). From FY2007, theInstitute initiated a project relating to productivity in Asian countries, and the results of the project are made public each year through publications.
Publications during FY2009 included the Library of Keio University Sangyo Kenkyujo (three volumes) and Keio Economic Observatory Discussion Papers (five volumes).

Institute for Media and Communications Research http://www.mediacom.keio.ac.jp/english/about.html
In FY2009, the Institute for Media and Communications Research conducted five research projects using research funds, special
contributions, and educational promotion funds (an internal grants-in-aid program). The results of the research were published ina journal outline and an independent volume.
Published research included:
Keio Media and Communications Research No. 60 (March 2010)
Keio Communication Review No. 32 (March 2010)
Sociology of Globalization: Collective Life and the Media in Circulation by Yoko Ogawa (Nishiaki), Kenichi Kawasaki, Mayuko Sano,eds.; Kouseisha-kouseikaku Corporation (March 2010)
Part of the research results

Institute of Cultural and Linguistic Studies

http://www.icl.keio.ac.jp/

The Institute of Cultural and Linguistic Studies has full-time staff and conducts basic research on subjects such as the various languages, cultures, and philosophies around the world, and on linguistics
and linguistic theory. The Institute promotes a varied range of research projects together with scholars both from within Keio and outside. In FY2009, it issued Report of The Keio Institute of Culturaland Linguistic Studies No. 41 (March 2010) and "The People and Its culture Viewed by Literary Men of Asia" (March 2010).
The Institute also invites eminent scholars from Japan and overseas to a wide range of international conferences, symposia, and lecture meetings, such as the Tokyo Conference on
Psycholinguistics (TCP), linguistics colloquia (six times a year), an Islam lecture meeting, and three courses that are open to the public. The TCP report was published as a collection of research papers
in English. In addition, the Institute has set up special courses relating to languages that are not offered by any academic department (23 courses on 11 languages).
Mita Campus 12

Hiyoshi Campus

Research Centers

For Inquiries:

Hiyoshi Campus
Research and Education Centers
Open to the Neighborhood,
Aiming for Collaboration withSociety and the Local Community

Hiyoshi Campus
4-1-1 Hiyoshi, Kohoku-ku,
Yokohama-shi,
Kanagawa, 223-8521 Japan
TEL: +81-45-566-1000

The Hiyoshi Campus houses seven faculties (Letters, Economics, Law, Business and Commerce, Medicine, Science and Technology, andPharmacy) for first and second year students; three graduate schools (Keio Business School (KBS), System Design and Management (SDM), and KeioMedia Design (KMD)); and six research institutes. The Campus expects to develop collaborated research activities in various academic domains.

Graduate School of System Design and Management (SDM) http://www.sdm.keio.ac.jp/
The Graduate School of System Design and Management (SDM) is eager to promote international collaboration. On October 26, 2009,
SDM signed a comprehensive bilateral agreement on human exchanges and joint research with the Faculty of Technology,
Policy and Management of Delft University of Technology (TU Delft TPM), with the attendance of Dr. Ronald Plasterk, Minister of
Education, Culture and Science of the Netherlands. At the same time, SDM held the first joint workshop, inviting President
Jacob Fokkema of TU Delft and 15 professors from the TU Delft TPM. After three keynote lectures, sessions were held in four groups.
The project for the alliance has been named "Kompas" (originating from the Dutch word for compass). The second joint
workshop was held at TU Delft in late May 2010. In FY2009, three students from each institution participated in a student
exchange program under the comprehensive bilateral agreement.
First joint workshop with the TU Delft TPM

Graduate School of Media Design (KMD)

http://www.kmd.keio.ac.jp/

The Graduate School of Media Design (KMD) has celebrated its first graduates since it was established. The unique value of KMD lies in the extensive domains of
its activities. Its graduates will play an active part in various fields, including the doctoral program.
KMD is actively engaged in a variety of activities such as "10,000 Women Initiative," in collaboration with Goldman Sachs Group, Inc., aimed at fostering 10,000
entrepreneurial women in emerging countries. Other activities include joint research with corporations, joint research with overseas universities, researchcommissioned by government-affiliated agencies, including the Core Research for Evolutional Science and Technology (CREST) of JST, and co-sponsoring of the Workshop
Collection.

"Workshop Collection," held at the Hiyoshi Campus

Graduate School of Business Administration (KBS) http://www.kbs.keio.ac.jp/

Research and Education Center for Natural Sciences http://www.sci.keio.ac.jp/

KBS sponsored a symposium focusing on the values of "Business School Programs," as well as aworkshop specialized in manufacturing, both in October 2009. It also held the second
international joint research workshop with Tsinghua University (China) and KAIST (South
Korea) in December 2009.
In January 2010, KBS signed a comprehensive agreement with Kobe University Graduate
School of Business Administration and Graduate School of Management, Kyoto University, and helda symposium entitled, "Initiatives for and the Direction of Education of Fully Fledged Members ofSociety," at Kobe University. The agreement isaimed at expanding the awareness ofbusiness school programs, developing newteaching materials, and promoting joint
research and collaborated classes, throughthe collaboration of three business schools
each with a different feature focus on
research based learning (Kobe University);
unification of humanities and sciences (Kyoto
University); and case method (Keio
Symposium focusing on the values of "Business School
University).
Programs"

Various research and educational activities in natural sciences are conducted at the Research and
Education Center for Natural Sciences, which was founded in April 2009. The activities vary widelyin their areas and range from cuttingedge academic research to practicalresearch performed in collaboration withcorporations. The activities are quite
diverse in their contents and their scales.
The center further promotes collaboration
within the Keio Gijuku Educational
Corporation. In November 2009, theCenter organized its first symposium,
entitled, "Diversity and Fun in Natural
Sciences". The Center also held four
colloquia, given by invited speakers fromvarious fields of natural sciences.
Eddies for a liquid metal turbulent flow in a square duct, to whicha local magnetic field is applied

Hiyoshi Research Portfolio (HRP) 2009 - A Place to Introduce Research and Education Activities at the Hiyoshi Campus
The Hiyoshi Research Portfolio (HRP), which started in 2005, was held in 2009 for the fifth time. HRP 2009 featured an exhibit using a website that included
pages to present research/education activities by faculties. The website included a video to present the directors of the research centers and the directorsof the three graduate schools. In addition, there were pages for searching and reading about the research/education activities conducted at the
Hiyoshi Campus that used three parameters: the campus map, the field of research, and a research keyword. The website exhibit ended in success withaccess from both inside and outside Keio University and from overseas.

Campus map search display of the HRP2009 website

13 Hiyoshi Campus

Hiyoshi Campus
The Keio Research Center for the Liberal Arts http://lib-arts.hc.keio.ac.jp/en/index.html
The Keio Research Center for the Liberal Arts was founded in July 2002 to search for the ideal systems that liberal arts
education should adopt through multifaceted investigations and researches conducted in Japan and overseas, planning andmaking proposals for specific programs, and at the same time validating the effectiveness of those proposals throughexperiments. The approximately 200 members, from a wide range of educational organizations from affiliated schools andvarious campuses and institutes of the university, have been actively conducting research.
In FY2009, the Center promoted "Core Research" in two areas ("Keio University Educational Curriculum Research" and "Body and Mind
Project") and "Specialized Research" (consisting of the university education promotion program of MEXT and the "Project toFoster the Capability for Education Language through Education of the Body and Mind"). The Center has been establishingpartnerships with research facilities and scholars within and outside Keio University to expand research network in liberal arts. It
has also offered experimental courses, open lectures, and seminars, together with publishing and validating research results bothin print and on the web.
New literary education experimental classPeriodicals issued by the Center include: Annual Research Reports, Newsletters, Symposium Reports, CLA Archives, Activity Reports,
and Liberal Arts Research Center Library.

Keio Research Center for Foreign Language Education http://www.flang.keio.ac.jp/
The Keio Research Center for Foreign Language Education was founded in October 2003. One of the Center's primary missions is toconsider foreign language education across all Keio-affiliated schools. The Center has a total of approximately 90 staffs andresearchers working from elementary school to graduate school level, and is driving forward with its research activities. The Center
was selected as a center for the Academic Frontier Program for Promoting Research Excellence at Private Universities for its "Action
Oriented Plurilingual Language Learning (AOP) Project." This project furthers research into a comprehensive understanding of all study
stages from primary school to graduate school and increases the consistency of foreign language study, centered on English-language
education. In addition, the project focuses on the challenge of enhancing plurilingual and pluricultural capabilities incommunication. (http://www.aop.flang.keio.ac.jp/)
Periodicals: Journal of Foreign Language Education, Summary of Research Activities, and Keio Research Center for Foreign
Language Education Symposium.

Health Center

Foreign Language Lounge

http://www.hcc.keio.ac.jp/

The field of the Health Center's research is divided into physical and mental health. The Center is conducting research into
hypertension, diabetes, metabolic syndrome, obesity and other lifestyle-related diseases, as well as anorexia nervosa, cardiac
diseases, liver diseases, infectious diseases, respiratory diseases, and mental disorders. The Center is collaboratinginternationally on research into hypertension, strokes, and metabolic syndrome, and has published papers on these fields.
The Center published 47 papers written in English between 1972 and 1994, and 214 papers between 1995 and 2008. The Center has
published 20 to 25 papers a year since 2008. Members of the Center have also made presentations at international conferences suchas those held by the International Society of Hypertension and the American Diabetes Association.
Periodicals: The Bulletin of Keio University Health Center and the Annual Report of Keio University Health Center (published oncea year).
Health Center (Hiyoshi)

Sports Medicine Research Center

http://www.hc.keio.ac.jp/sports/

The Sports Medicine Research Center covers a broad range of activities in the field of sports medicine. It provides medical
support and education to collegiate as well as other recreational and professional athletes. The Center also emphasizes clinicalresearch on exercise and dietary therapy for the prevention and treatment of lifestyle-related diseases.
Since 2007, the Center has held open annual lectures on "Sports and Health" in partnership with the Graduate School of HealthManagement. In 2009, the Center introduced the latest information on "Sports and Mental Conditioning" through lectures andworkshops. The Center also cosponsored "Considering University and Sports," a symposium through an endowment from
Yamato Transport Co., Ltd. Its major research projects include: intervention study on metabolic syndrome and measurement of runningenergy expenditure (joint research with a corporation). With other research as well, the Center reports its results at domestic andinternational conferences on sports medicine and lifestyle-related diseases.
Measurement of oxygen uptake while running

Periodicals: Open Course Report and Newsletters.

Institute of Physical Education

http://www.hc.keio.ac.jp/ipe/

Since its foundation in 1961, the Institute of Physical Education has promoted the importance of health and sports to Keio
University students and teaching staff, and also local residents, through physical education courses within the university,
symposiums, and open courses. At the same time, the Institute has implemented a wide range of research related to physicaleducation, health, and sports. In FY2009, the Institute established an environment that enables photography and feedback using
underwater cameras in the pool of Kyoseikan, and started biomechanics research into swimming and sports methodologicalresearch. It also served as the secretariat of the Japan Association for Laser Medicine and Sports Science and held an
academic gathering.
Periodicals: Bulletin of the Institute of Physical Education and Activity Report of the Institute of Physical Education.

Photography using an underwater camera

Hiyoshi Campus 14

Research Centers

Yagami Campus

For Inquiries:

Yagami Campus
Opening Up the Next Frontiers of
Science and Technology

Secretariat of the KLL
c/o Office of Research Administration,
Yagami Campus
TEL: +81-45-566-1794
http://www.kll.keio.ac.jp/
E-mail: staff@kll.keio.ac.jp
KLL Liaison Office
TEL: +81-45-566-1438
http://www.kll.keio.ac.jp/liaison/index.html
E-mail: liaison@educ.cc.keio.ac.jp

Faculty / Graduate School of Science and Technology
The Faculty and Graduate School of Science and Technology are located at the Yagami Campus, where research andeducation centered on scientific and technological fields are conducted. With over 280 researchers, approximately 1,800
Master's and Doctoral students in the Graduate school are pursuing their studies and research, together with third and fourthyear undergraduate students. To inaugurate an education/research organizational system that enables graduate
students to pioneer unexplored fields with a liberal intellectual approach, the Graduate School of Science andTechnology established three schools in the year 2000 that make interdisciplinary approaches possible: the School of
Fundamental Science and Technology, the School of Integrated Design Engineering, and the School of Science for Open andEnvironmental Systems. We also provide an environment that cultivates a global perspective through various
international exchange programs, including the Double Degree Program. Based on our principle of "emerging", we consider it our mission to cultivate human resources
who will open up the next frontiers for themselves, take the initiative in contributing to science, technology and society, and play an active role on the world stage.
http://www2.st.keio.ac.jp/english/

Point of Contact for Research Collaborations
Keio Leading-edge Laboratory of Science and Technology (KLL) http://www.kll.keio.ac.jp/
The Keio Leading-edge Laboratory of Science and Technology (KLL) was established within the Graduate School of Science andTechnology (Yagami Campus) in April 2000 as a research center for promoting collaboration between industry, government, andacademia. It aims at making a social contribution through the creation of new businesses, energizing research activities, andproviding a university environment for exchanges with society in the field of science and technology. As a point of contact for
research collaborations with industry and public organizations, the KLL provides support relating to research agreements andoperates and manages research space. It also coordinates joint research and commissioned research projects.
To promote the social benefits of research achievements, the KLL provides a forum for networking with groups outside Keio
University, including industries through the operation and management of the database for introducing researchers' projects, the publicationof a bulletin, "New Kyurizukai", KLL Industry-Academia Collaboration Seminars and Keio Techno-Mall, Keio Science and Technology
Exhibition (Refer to p.16).

Research Coordination (Liaison Function)
The KLL, centering on the KLL Liaison Office, is promoting cooperation for research
work in the prepatent, or nascent stage. Experienced staff members introduce theresearch activities of the Yagami Campus from various viewpoints and respondflexibly to individual concerns. The KLL creates an interactive flow between
corporations and university research activities, and coordinates optimal joint andcommissioned research projects, whether within Japan or internationally.
Features of Industry-Academia Collaboration by KLL
Corporation

Productization & commercialization"KLL Specified Research Projects" and fostering of nascent researchand young researchers
Every year, the KLL calls for "KLL Specified Research Projects" with the objective of
focusing on the development of emerging research fields that are considered to beimportant to society in the future, to create new research fields and encourage thefostering of leaders in those fields.
The KLL also provides research grants to master's and doctoral program students,
with the objective of fostering outstanding scholars in the fields of science andtechnology. In FY2009, the KLL extended grants of ¥300,000 to each of 122 students in
doctoral programs. It has also set up a system to assist with partial travel expenses tostudents in master's programs, to enable them to present their research atinternational academic conferences. A total of 112 students used this system.

Patenting of achievements
Keio University Intellectual
Property Center

Seeking advice for
productization

Selected "KLL Specified Research Projects" in FY 2009 (Examples)

Applied research
R&D

Seeking solution technology
for a certain issue

Leading-edge researchknowledge

What should be next
theme of research?

Flexibly coordinating various
collaboration styles

Wishing to start up a
new businessCommissioned research
Joint research
Opinion and information exchange
Technological guidance

Seeking expert's
evaluation
Wishing to entrust basic
research to Keio

Basic research

15

Advice andconsultation on issues
Joint study on
new development“A Study on Advanced Methods for Cause-Effect Analysis and their
Application to Consumer's Cognitive Modeling in Service”
Hideo Suzuki, Associate Professor, School of Science for Open and Environmental Systems“Development of Carbon Nanotube Electroluminescence Device”
Hideyuki Maki, Assistant Professor, School of Integrated Design Engineering

Demonstration, verificationand evaluation

Keio University
Graduate School of
Science andTechnology“Development of a Spectrometer for Radio Observations of X-ray
Dissociation Regions in the Galactic Center Region”
Kunihiko Tanaka, Research Associate, School of Fundamental Science and Technology

Yagami Campus

Promotion of Leading-edge Research
Changes in Research Funds by Type Over the Past Five Years(Yagami Campus)
Thousand Yen
Type of Research Funds

FY2005

FY2006

FY2007

FY2008FY2009

University Funds

136,014

137,721

96,222

160,759

144,370

1,677,319

1,753,579

1,246,782

1,637,905

1,538,944

Grants85,03953,30033,68057,76089,720Specified Donation

129,969

104,720

101,467

118,557

123,256

Subsidies

1,440,404

1,198,498

1,768,086

1,172,136

1,442,880

Joint Research

329,835

346,359306,365

290,801

157,311

Others26,875

8,475

3,295

1,221

4,192

Total

3,825,455

3,602,652

3,555,897

3,439,139

3,500,673

Commissioned Research

Changes in research funds by type over the past five years (from FY2005 to FY2009) are asshown in the table above. Projects through collaboration between industry, government, andacademia are actively carried out on the Yagami Campus. With regard to the number ofprojects by fund source in FY2009, private corporations accounted for 216 cases andgovernment agencies, public-service corporations, etc. accounted for 103.

Research Subjects (Examples)
MEXT Grant-in-Aid for Scientific Research (S)“Development of Innovative Nano-Micro Level Thermophysical Properties
Sensing Techniques and Their Applications”
Yuji Nagasaka, Professor, School of Integrated Design Engineering

MEXT Grant-in-Aid for Young Scientists (S)“Strategic Research to Solve Certain Conjectures in Arithmetic Geometry”
Kenichi Bannai, Assistant Professor, School of Fundamental Science and Technology

JST Exploratory Research for Advanced Technology ERATO NAKAJIMA
Designer Nanocluster Assembly Project“Study on Fine Controlled Synthesis, Designer Assembly, andCharacterization of Advanced Functional Nanoclusters, Aiming at New NanoMaterial Science Consisting of Nanoclusters”
Atsushi Nakajima, Professor, School of Integrated Design Engineering

JST Core Research for Evolutional Science and Technology Fundamental
Technology on Dependable SoC and SiP for Embedded Real-Time Systems“Research and Development on Dependable SoC and Dependable OS”
Nobuyuki Yamasaki, Associate Professor, School of Science for Open and Environmental
Systems

Keio Photonics Research Institute (KPRI) (Location: Keio University Shin-Kawasaki Town Campus)
The Keio Photonics Research Institute (KPRI) was founded in April 2010 as a laboratory affiliated with Keio
University's Faculty and Graduate School of Science and Technology. It's objective is to carry through research on the"Creation of Face-to-Face Communication Industry by Ultra High-Speed Plastic Optical Fiber and Photonics Polymers forHigh-Resolution and Large-Size Display" (Chief Researcher, Yasuhiro Koike, Professor, School of Integrated Design
Engineering, Graduate School of Science and Technology), a FY2009 program funded by the Funding Program forWorld-Leading Innovative R&D on Science and Technology (FIRST) of the Cabinet Office. This institute is solely
responsible for the unified management of funds and R&D support in regards to this research.
http://kpri.keio.ac.jp/

Professor Yasuhiro Koike, Chief Researcher

Returning of Research Achievements to Society / Introduction of Researchers
Science and Technology Exhibition (Keio Techno-Mall)

New Kyurizukai

The KLL holds the Science and Technology Exhibition (Keio Techno-Mall) every
December to inform the public about the Faculty and Graduate School of Science andTechnology's research achievements and to attract corporate interest in collaborative
projects. The exhibition emphasizes demonstrations and hands-on exhibits that
visitors can actually see and touch the research results.
In 2009, when the KLL celebrated its 10th anniversary, an exhibition was held topresent the latest developed technologies and research, under the theme of "Shaping the
Future through Science," featuring approximately 70 booths to introduce researchachievements, 14 collaboration technology seminars by researchers and tworoundtable sessions: "A Society where humans and robots can coexist" and "Living in thewireless age." A talk session was also held to look back on the 10 years of the KLL andconsider the optimum means by which industry and academia should collaborate. The
1,300 visitors engaged in enthusiastic exchanges. The 2010 exhibition is scheduledfor December 10 in Halls B7 and B5 of the Tokyo International Forum in Yurakucho.

Today in the 21st century, science and technology continue to become increasingly
diverse and difficult. The Faculty of Science and Technology launched a bulletin,"New Kyurizukai," in 2009, with the aim of explaining
research in the field of science and technology in an easy-tounderstand way. The bulletin returns to the starting point of"Kinmo Kyurizukai," the first scientific guide in Japan
published by Yukichi Fukuzawa in 1868. Three issues are
published in each fiscal year, with each issue featuring ayoung researcher. The Faculty issues the bulletin in theform of booklet in Japanese and also PDF files in both
Japanese and English. A full version of the interview that isfeatured in the booklet is available on the website.
http://www.st.keio.ac.jp/kyurizukai/index.html
Initial issue: Junichi Ushiba,
Assistant Professor

KLL Industry-Academia Collaboration Seminars
The KLL holds Industry-Academia Collaboration Seminars three times a year incooperation with Yokohama Industrial Development Corporation and Institute ofIndustrial Promotion Kawasaki, mainly targeting the relevant people in industrial
circles in the regions that are considering joint research/joint development with the Facultyand Graduate School of Science and Technology. A specific topic is set for eachseminar, and a researcher specializing in the topic introduces latest researchachievements and technology. In FY2009, the KLL held the following seminars, andmany relevant company representatives attended them.
The 5th Seminar (July 17, 2009): "Initiatives for human interface"
The 6th Seminar (October 23, 2009): "Green manufacturing"
The 7th Seminar (February 26, 2010): "Colorfully expanding potentials of 'light'"
Scene at the Keio Techno-Mall 2009 exhibition

Demonstration at a booth

As for FY2010, two seminars were held on July 23 and October 29, 2010. The third seminar will be held on
February 25, 2011.

16

Shinanomachi Campus

Research Centers

Shinanomachi Campus
Center for Translational Research~ from Bench to Bed ~For Inquiries:
Shinanomachi Office of Research Administration
TEL: +81-3-5363-3879
http://www.med.keio.ac.jp/researchers/
E-mail:ras-shinanomachi@adst.keio.ac.jp
Keio University Medical Science Fund
TEL: +81-3-5363-3609
http://www.ms-fund.keio.ac.jp/index_jp.htm
E-mail:k-msf@adst.keio.ac.jp

The Shinanomachi Campus brings together medical education, research, and care facilities, such as the School of Medicine (second-year to sixth-year
students), the Faculty of Nursing and Medical Care (third-year students), the Graduate School of Medicine, and the University Hospital.
The Research Park at the Center for Integrated Medical Research houses research units involving other faculties, universities and research
institutions, as well as business enterprises. It promotes strategic interdisciplinary research in the field of life sciences that extends beyond
conventional paradigms of research areas and organizations.
The Center for Clinical Research is situated in the Building for Clinical Research completed in 2008 to provide support for clinical trials andtranslational research.
http://www.sc.keio.ac.jp/

School of Medicine and Graduate School of Medicine http://www.med.keio.ac.jp/
The School of Medicine was established in 1917, with a world renowned bacteriologist ShibasaburoKitasato as the first Dean. To overcome the various problems caused by each department working
independently, Professor Kitasato instituted a large-class system, which emphasized cooperation
between basic and clinical medicine, and the practice of medicine as a practical science. In an effort to carryout the medical education that Professor Kitasato had envisioned, the doctoral program of the Graduate
School of Medicine was launched in 1956 and the master's course in 1994 to foster trustworthy medical
personnel who combine knowledge, skills, and a well-rounded personality.
Portraits of Yukichi Fukuzawa and Shibasaburo Kitasato

Center for Integrated Medical Research http://www.cimr.med.keio.ac.jp/
The Center for Integrated Medical Research aims to develop interdisciplinary research of medical
science, science and technology, social science, and environment and information engineering. It also strives
to make contributions to society through their research achievements.
Promoting expansion of diverse advanced research in life sciences, the Research Park, which acts as theCenter's strategic research division, leases space (limited, in principle, to 3 years) to research units
formed of researchers from various disciplines and institutions who share common objectives.
The Center's "Type J" system provides opportunities for young researchers to be principal investigators todevelop groundbreaking research under favorable conditions. The Center also provides space for large-scale
projects conducted with research funds from both inside and outside the university, and it functions as theresearch center for those projects.

Institute of Integrated Medical ResearchCenter for Clinical Research (CCR) http://www.ccr.med.keio.ac.jp/
The Center for Clinical Research is where the School of Medicine and the Keio University Hospital
combine to conduct clinical trials and clinical/translational research (clinical research) that contribute to thedevelopment of innovative, advanced medical treatments and revolutionary drugs. The Center provides
support for research implementation, starting with consultation at the planning stage and following
through from subject recruitment to bio-statistical analysis. It also provides educational research
programs for medical personnel.
Beyond clinical research by individual researchers or clinical departments, the Center promotes
systematic clinical research, implementation of clinical trials, and the establishment of support systems
backed by the School of Medicine, the University Hospital, and affiliated institutions.

Building for Clinical Research

Keio University Hospital http://www.hosp.med.keio.ac.jp/
The Keio University Hospital has 29 clinical departments, 5 central treatment groups, and 7 crosssectional cluster divisions of the School of Medicine and the hospital. The hospital receives an average of
4,000 outpatient visits per day and has about 950 inpatients. It accepts over 20,000 emergency patients andhandles nearly 10,000 general-anesthetic surgeries per year. The hospital provides advanced medical
treatments as a tertiary hospital and promotes regional medical care through staff exchanges andmedical collaborations with over 100 hospitals all over Japan.
Keio University Hospital

17

Shinanomachi Campus
Endowed Laboratories in the School of Medicine
and the Graduate School of Medicine

Research Funds at Shinomachi Campus

University Funds

Joint
Research

Commissioned
Research

Joint Research Projects

Kyorin Pharmaceutical, Asahi Kasei Kuraray Medical
Clinical Research Center of Inflammatory Bowel Disease

Novartis Pharma K. K.
Exploratory research for new therapeutic targets in cardiorespiratory
medicine

Bridgestone Laboratory of Developmental and Regenerative
Neuroscience

Institute of Medical Molecular Design, Inc
Renoprotective Drug Development targeted to NFkB

Johnson & Johnson Ocular Surface Visual Optics

Ono Pharmaceutical Co., Ltd.
Search for and functional analysis of therapeutic targets in COPD

Department of Musculoskeletal Reconstruction andRegeneration Surgery

Kowa Company, Ltd.
Clarification of the physiological role of oxidant stresses in dry-eye

Inaida Research Center for Anti-Aging Medicine in HepatoGastroenterology

Shionogi & Co., Ltd.
Clarification of molecular structures in renal aging and cardiorenal
linkages, and clinical application to cardiovascular accident outbreakcontrol of chronic kidney disease

Endocrinology and Anti-aging Medicine

Subsidies

Center for Gastroenterology and Clinical Oncology Research(CGCOR)

Specified
Donation(Research)

Novartis Pharma Program for Clinical Therapeutics ofHematologic Malignancy

Daiichi Sankyo Co., Ltd.
Molecular biological therapeutic strategies for prevention of
metabolic syndrome and their clinical application

Novartis Pharma Program for Cerebrovascular Disease
Prevention Medicine

Thousand Yen

Department of Cell Biology and Neuroscience

Toshiba Medical Systems Corporation
Non-invasive radiotherapy and diagnostic system for cancer
management

Department of Advanced Therapy for Spine and Spinal Cord
Disorders

Otsuka Pharmaceutical Co., Ltd.
Basic study for development of new therapies in digestive diseases
LinkGenomics, Inc
Development program from diseases caused byepithelialtomesenchymal transition (EMT)

University Funds

0,211,675

Subsidies

3,892,416

Schering-Plough Center for the Study of Chronic Liver
Diseases

3,700

Department of Anti-Aging Musculoskeletal Research

Grants (Research)Specified Donation (Research)

1,925,574

Molecular Metabolism and System Medicine

Commissioned Research

1,913,200

Daiichi Sankyo Cardiovascular Inflammation

Joint Research
Total

0,0923,053
8,869,618

Mitsubishi Tanabe Pharma Corporation
Creation and functional evaluation of artificial blood platelets bynanoparticles supported by molecule recognition sites

Ajinomoto Co., Inc.
The pharmacological action of amino acids in Crohn's disease andanalysis of changes in amino acid metabolic balance underpathology

Tokyo Electric Power Company Advanced Medical Sciencesand Environmental Preventative Medicine

Kyowa Hakko Kirin Co., Ltd.
Expansion and Maintenance of Hematopoitic Stem Cells in vivo andin vitro

Integrated Renal Replacement Therapy and Translational
Medicine

NIPRO Corporation
Research and Development of Artificial Oxygen Carrier

Frontier Medicine on Metabolic Syndrome

Eisai Co., Ltd.
Comprehensive research project of dementia toward theestablishment of a dementia center in the School of Medicine of
Keio University

Department of Integrated Bone Metabolism and Immunology(Teijin Pharma)

Twelve other joint projects

Department of Clinical Biomechanics(Hisamitsu Pharmaceutical)
Network Medicine on Endocrinology and Metabolism

Faculty of Environment
and Information Studies,
Faculty of Nursing andMedical Care,
Faculty of Pharmacy,
etc.

Shinanomachi Campus
Graduate School of Medicine/School of Medicine

Faculty andGraduate School of
Science andTechnology
SeminarCenter for Integrated
Medical Research

Research Park
Research Park

From Bench to Bed
Tsuruoka Town
CampusCenter for Translational ResearchShin-Kawasaki
Town Campus

Keio University Hospital
University Hospital

Keio University Medical Science Fund
In fall 1994, Dr. Mitsunada Sakaguchi, a 1940 alumnus of the School of Medicine,
donated five billion yen to Keio University, with the expressed desire that it be used toencourage medical research and its creative progress at Keio and to promoteworldwide medical advances. To fully reflect Dr. Sakaguchi's commitment, Keiolaunched the Keio University Medical Science Fund on April 1, 1995. Dr. Sakaguchi madean additional donation of two billion yen in July 1999, bringing the fund to a total of 7
billion yen.

Keio Medical Science Prize
Keio Medical Science Prize honors theoutstanding and creative achievements ofresearchers in the field of the medical and life
sciences, in particular those contributing toscientific developments in medicine. The prize isawarded irrespective of nationality. Laureatesreceive a certificate of merit, a medal and amonetary award of 20 million yen. The award
ceremony, commemorative lectures given by the laureates and commemorative
symposium are held at Keio University.

18

Shonan Fujisawa Campus

Research Centers

Shonan Fujisawa Campus (SFC)
Contributing to Social
Development with Cutting-edge
Research Based on
Interdisciplinary CooperationSFC
The Shonan Fujisawa Campus (SFC) wasestablished in 1990 with the aim of creating a site forresearch and education based on completely new
concepts adapted to the changing times. In
addition to the three faculties of Policy
Management, Environment and Information
Studies, and Nursing and Medical Care, it also has
the Graduate School of Media and Governance,
which aims to foster highly professional people
who will play a major role in 21st Century society,and the Graduate School of Health Management,
which further expands and develops the concept of
the Faculty of Nursing and Medical Care byproviding a program that enables graduates ofboth the sciences and humanities to tackle thebroad subject of "Health." Situated on a futuristic
330,000 square meter campus, SFC seeks tomaintain a balance between advanced technology
and a rich, natural environment. Research projects
serve as the core of a participatory curriculum
which instills students with specialized knowledge
and practical skills.
http://www.sfc.keio.ac.jp/en/

Keio Research Institute at SFC
The Keio Research Institute at SFC is an affiliate
institute of the three SFC faculties and the
Graduate School of Media and Governance, which
promotes research activities at SFC.
As a leading center of cutting-edge research in the
21st century, the Institute works to further
enhance society's advancement by performing
ground-breaking
research
basedoninterdisciplinary cooperation and by nurturing a
two-way partnership between educational andresearch activities at the campus. This includes all
related activities with industry, government, andacademia both within Japan and overseas.
Specific measures to achieve these objectives
include the promotion of joint research projects
with other organizations and the support ofventure incubation efforts. A feature of the Keio
Research Institute at SFC is the SFC ResearchConsortium, which encourages university-led
collaborative research by multiple organizations.
There are currently 12 such projects under way (as ofJune 1, 2010).
The Institute has also been commissioned to
execute about 170 research projects per year,
funded by approximately ¥2.07 billion fromgovernment agencies, local governments, andprivate companies (FY2009 data).
This research is performed not just by researchers
within SFC, but also by approximately 430 visiting
researchers from outside.
The Institute is committed to presenting the fruits of
its research widely to the public so that the results of
its efforts can be returned to society.
http://www.kri.sfc.keio.ac.jp/en/

For Inquiries:
Shonan Fujisawa Office of Research
Administration
TEL: +81-466-49-3436 FAX: +81-466-49-3594
E-mail: info-kri@sfc.keio.ac.jp
Website of Keio Research Institute at SFC:
http://www.kri.sfc.keio.ac.jp/en/

Disseminating Research Results Broadly

SFC Open Research Forum (ORF)
Keio Research Institute at SFC, with the notionthat dissemination of its achievements to the
public is one of its crucial obligations, holds the
SFC Open Research Forum as the occasion toannounce broadly its research outcomes. In thisforum future prospects and results of many
ongoing research projects of the institute are
introduced to industries, national and local
governments through exhibitions, demonstrations
and symposia.
The institute also makes proposals for societies at
the forum through various sessions such as panel
discussions between experts from industries andgovernments and researchers of SFC. The SFC
Open Research Forum thus intends to facilitateand enhance industry-government-academia
activities at SFC, and is an occasion for the
institute to have external and objective
assessments of its activities for development of its
future research plans. The two-day SFC Open
Research Forum 2010 will be held November 22
and 23 at Roppongi Academyhills 40 in Tokyo.
http://orf.sfc.keio.ac.jp/

SFC Research Yellow Page
Keio Research Institute at SFC runs a web searchservice named "SFC Research Yellow Page" topublicize diverse research activities by researchers of
SFC to an even larger number of enterprises andorganizations. The service is for promotion oftransdisciplinary research endeavors leading toactualizations of new research projects as well as
consequent technology transfers and generationsof new businesses through producing
opportunities of encounter between social needs
and research activities at SFC.
http://www.kri.sfc.keio.ac.jp/kris-yp/

Faculty of Nursing and Medical CareSFC Open Research Forum 200919 Shonan Fujisawa Campus (SFC)

SFC Research Yellow Pages

Shonan Fujisawa Campus
Keio Research Institute at SFC

Society

Presentation of Case Examples
Laboratory
Private BusinessResearch Institutes

SFC ResearchConsortium

Returning of Research
Outcomes to Societies

Contract /Grant-in-aid
Joint Research Research

Disclosure of Information

Educational Institutes
Governments

Contribution to Society

Others

Structure of Keio Research Institute at SFC

World-Leading Fusion Research Technology
Laboratory

SFC Research Consortium

The Keio Research Institute at SFC provides a laboratory
system which enables SFC's researchers to form
research groups with people who have different
academic backgrounds yet share the same researchinterests and objectives. These groups carry out
interdisciplinary collaborative research projects.
Currently, the following 20 laboratories are active (as ofJune 1, 2010):

The SFC Research Consortium is a unique form of
research collaboration in which the university sets thecentral research theme, invites a number of externalorganizations such as business enterprises andgovernments for collaborations, and tackles large
research issues while sharing mutual benefits.
Currently, the following 12 consortium projects areactive (as of June 1, 2010):· Career Resource Laboratory· Internet Research Laboratory· Geo-informatics Laboratory· Systems Biology Laboratory· Auto-ID Laboratory· Ubiquitous Computing & Communication Laboratory· Platform Design Laboratory· Healthcare Informatics Research Laboratory· Keitai Laboratory· Interaction Design Laboratory· Community Collaboration Laboratory· Open Wireless Broadband Platform Laboratory· Asian Laboratory· Mieru-ka Laboratory· Advanced Web Application Laboratory· Agri-Informatics Laboratory· e-Government Research & Development Laboratory· Japan Studies Platform Laboratory· Shonan Institute for the Computational Research of· Acoustics and Music· Internet and Society Laboratory
http://www.kri.sfc.keio.ac.jp/en/activity/
laboratory.html· Building Advanced Information Infrastructure· Sharing Human Intellect Project· VCOM· VSI (Virtual Systems Institute)· E-CELL Consortium· e-Care Consortium· Keio SFC Innovation & Entrepreneurship Platform· Consortium· Referenced Code Development for IMS/SIP system· Unwired Research Consortium· Internet Business Innovation consortium· Regional Informatization Research Consortium· Agri-Platform Consortium
http://www.kri.sfc.keio.ac.jp/en/activity/
consortium.html

Ground-Breaking Partnerships with Industry, Government, and Academia
SFC Forum

Venture Incubation Support

The SFC Forum is a hub of communication, whereleaders of the business world and university faculty
can hold discussions spanning a wide range of fields. The
program for the regular lunch meetings, which are apillar of the movement, reached a turning point at the100th meeting in 2010. Having marked its 20th
anniversary, SFC provides seminars by instructors invarious specialist fields for the new decade.
http://sfc-forum.sfc.keio.ac.jp/

Keio University has set up incubation facilities (KeioFujisawa Innovation Village) in cooperation with theOrganization for Small & Medium Enterprises andRegional Innovation, Fujisawa City, and Kanagawa
Prefecture.
These facilities are offered for rent, subject to local
conditions suitable for industrial startups, to those whowish to utilize the fruits of university research to create
new businesses, or to those who wish to form newcompanies in partnership with university researchers
who already have suitable expertise.
A number of incubation managers are available on-site togive support such as advice on industrial startups andmatchmaking with corporations.
Since their establishment in March 2006, the facilities
have maintained an occupancy ratio of over 80%. The
facilities offer various kinds of support for fund-raising,legal matters, intellectual property, collaborative
activities between industry and academy, etc., enablingindustrial startups to proceed smoothly to fullcommercialization.

SFC forum

Case 1:Jiro Kokuryo's Laboratory, Faculty of Policy
Management:
Contemplating an image of the future of the Internet
economic society and the shape of policies
The Internet Business Innovation Consortium has been
striving to identify the requirements for increasing thecreativity of Internet businesses and returning innovation to
the society, enabling society to benefit from the results.
In February 2010, vice ministers and parliamentary viceministers of the government ministries who draw up
Japan's IT policies, as well as the high-ranking executives of
IT companies, gathered to attend a symposium to discuss
face-to-face an image of the future that will be brought
about through the creative and comprehensive use of theInternet. The attendees also discussed the obstacles toattaining this future image.
At the event, several thousand individuals simultaneously
watched a live program distributed through Ustream, andthere were more than 10,000 tweets, which madeproceedings very exciting. The Consortium will continue
with its research in cooperation with Consortium
members to make recommendations that will enable theresearch results to be reflected in policies.

Kick-off Symposium (Feb. 2010)

Case 2:
Open Wireless Broadband Platform Laboratory:
A new service using the wide-area wirelessnetwork by WiMAX: Digital Signage
Wireless telecommunications, such as mobile phones andwireless LAN, now play a critical role in everyday life
because of their convenience. However, there are many
problems associated with wireless telecommunications.
These include technical problems, such as radio
interference and band limitation, as well as issues
concerning laws, regulations and standardizations related toradio transmissions. However, with the advances made intechnology and standardization, it has become possible toinstall radio technology in information systems as afunctional block, and new methods of utilizing radio
technology are being studied.
The Open Wireless Broadband Platform Laboratory
researches new communications and new services thathave become possible by opening up the wirelessplatform from the business and technological aspects.
Digital Signage (an electronic message board system) is
one such service. Within the SFC campus, the Laboratory
performed a test demonstration of the Dynamic Digital
Signage, a new type of information distribution service
that provides regional and other information that matches
the attributes of people around the display. In addition,
the Laboratory has been developing Fujisawa Signage, asystem through which citizen reporters can distributeregional information to the designated message board at thedesignated time in cooperation with the Fujisawa
municipal government. This is facilitated by using means
such as the wide-area wireless network by WiMAX,
which has been established in the Shonandai area.

Digital Signage

20

Shiba-Kyoritsu Campus

Research Centers

For Inquiries:

Shiba-Kyoritsu Campus
Platform for the dissemination of
information to guide the future ofpharmaceutical sciences

The Group for Research Administration,
General Affairs Office, Shiba-Kyoritsu campus
1-5-30 Shibakoen, Minato-ku, Tokyo,105-8512 Japan
TEL: +81-3-5400-2653
http://www.pha.keio.ac.jp/
E-mail: skc-shien@adst.keio.ac.jp

Faculty of Pharmacy / Graduate School of Pharmaceutical Sciences
The Faculty of Pharmacy and the Graduate School of Pharmaceutical Sciences were set up in April 2008 as the result of a merger with Kyoritsu University of Pharmacy.
After this merger, we continued to use the equipment and facilities at the Shiba-Kyoritsu Campus in Shibakoen, Minato Ward for education and research. Over theperiod of eight decades since its establishment in 1930, Kyoritsu University of Pharmacy has turned out some 13,000 pharmacists and pharmaceuticalresearchers and has attained a leading position in the field of pharmaceutical research. By carrying on this outstanding track record and building on thecomprehensive capabilities of Keio University, we hope that this new Faculty and Graduate School will continue to lead the way forward in the field ofpharmaceutical sciences with regard to education, research and contributing to society.

Aims of the Graduate School of Pharmaceutical Sciences
Pharmaceutical sciences are under increasing pressure to deliver results not only for the benefit of society but also
for improving the quality of medical care. To promote the latest medical advances and contribute to the nation's
health, the mission of the Graduate School of Pharmaceutical Sciences is to foster the ability to gather
information from around the world, acquire knowledge of advanced leading-edge medical treatments, andeducate talented individuals with specialist skills.
At the Graduate School of Pharmaceutical Sciences, we carry out advanced pharmaceutical education andresearch in a diverse range of pharmaceutical disciplines including pharmaceutical science, chemotherapy,
biochemistry, drug targeting (delivery), patient compliance instruction/drug dispensing, medical productinformation, pharmacokinetics, drug information, pharmacology and pathology. Our aim is to produce
researchers and engineers capable of developing new medical products, and to nurture talent in all manner ofsituations including clinical research organizations (CROs), food manufacturers, the chemical industry, developers of cosmetics, and government facilities.
In each of these fields, we aim to incorporate international aspects into the education and research activities at the Graduate School in order to produce
individuals who are capable of operating on an international level.

Collective strengths of Keio University

Platform for the dissemination of information to
guide the future of pharmaceutical sciences

Links with other organizations· Graduate School of Medicine(Graduate School GP joint project)· Graduate School of Science and Technology· Graduate School of Health Management· School of Medicine· Faculty of Science and Technology· Faculty of Environmental Information Studies· Faculty of Nursing and Medical Care
· Shin-Kawasaki Town Campus· Tsuruoka Town Campus· Keio University Medical School Hospital(training venue for pharmaceutical students)

Graduate School of
Pharmaceutical Sciences· University / graduate school· Foreign academic exchanges· Hospitals and pharmacies oftraining partners· Research laboratories· Local government(Tokyo city, Minato ward, etc.)· Corporations (joint studies,
research commissions)

Major inpharmaceuticalscience

Major inpharmacy

Major in clinicalpharmacy

Faculty of Pharmacy (pharmacy / pharmaceutical science)· Pharmacy media center· Center For Molecular Target· RI laboratory facilities
Drug Research· Shiba-Kyoritsu ITC· Faculty of Pharmacy dispensary· Laboratory animal breeding facility · Medicinal plant garden

Shiba-Kyoritsu Campus

Center For Molecular Target Drug ResearchThis center was established to contribute widely to the development of molecular targeted therapeutic research and to efficiently promote the formation of a DVD
research and development center for cell signaling targeted drug discovery in support of strategic research by private universities and MEXT. It does this by bringing
together leading researchers at the Graduate School of Pharmaceutical Sciences and by carrying out basic research and development. The center also takes careof the administrative and business aspects of research apparatus necessary for leading-edge research.

Nuclear magnetic resonance (NMR) equipment
This equipment obtains information about the 3D structure and specificnuclear bonding states in chemical compounds by subjecting them toelectromagnetic pulses tuned to resonate with atomic nuclei that spin when
the compound is placed in a magnetic field. This is a powerful technique forthe structural analysis of natural materials and organic compounds.

21

Flow cytometer
This equipment rapidly separates cells by using various indicators such as
surface antigens. This makes it possible to analyze the properties of cellgroups in a short time, and to separate still-living cells based on theirindividual properties.

Confocal laser scanning microscopeThis microscope can produce high-definition 3D visualizations of thestructure of biologically active molecules such as proteins and nucleic acids,
and the locations of these molecules inside cells. Uses include making
prolonged observations of living cells, and stimulating cells with light of a
specific wavelength.

Shiba-Kyoritsu Campus

From drug discovery to clinical trial — Conducting
extensive research on the "Pharma Sciences" toutilize the multi-faceted nature of pharmaceutics
At the Graduate School of Pharmaceutical Sciences, we aim to build on the collective
strengths of Keio University while improving our research level links with othergraduate schools, and we will continue to promote links between government,
business and academia in the field of pharmacy by promoting exchanges of students andteaching staff. In addition, we aim to teach and research the latest technology, and areworking at further strengthening our research infrastructure by actively inviting
eminent researchers from outside the university, especially from foreign educational
establishments.

Supporting the Formation of a Strategic Research Infrastructure
In addition to the independent research achievements made in each of the 20 or
so courses we have on offer, the Graduate School of Pharmaceutical
Sciences has also been selected to participate in the Strategic ResearchBase Development Program of MEXT, which is a cross-disciplinary research
project that includes participation from external organizations.

Formation of a DVD research centre in cell signaling drug discovery
for molecular targeting therapies(2009-2013 Research Representative: Professor Hideko Kanazawa, Faculty of Pharmacy)
Due to recent pharmaceutical developments including the molecular-targeted drug,
substantial improvements have been made in the treatment of hitherto intractablediseases, and as a result many patients now experience a better quality of life. We aim to leadthe world in drug discovery by establishing a research system with deeper links tofacilities such as the Graduate School of Medicine and Graduate School of Science andTechnology centered on the Center For Molecular Target Drug Research which wasestablished as a research center in the Graduate School of Pharmaceutical Sciences.
Specifically, we will construct a centralized drug discovery research system that brings
together the know-how and technology of drug discovery, such as drug design andsynthesis, drug screening (D; design), analysis of pharmacological / biological action,
investigation of pharmacokinetics and metabolites (V; validation), and drug delivery (D;delivery). Furthermore, by strengthening our research links with other universities, we aim to
discover new drug discovery targets and seeds originating from universities, and toencourage new growth in practical research.
Within the research period, we aim to (1) design promising candidate compounds fortherapeutic drugs, (2) focus on the target diseases of cancer, immunity, dementia, anddiabetes, and search for target molecules and analyze their interaction, and (3) elucidate themechanisms of drug delivery for the clinical application of therapeutic drugs that target thedisease at the molecular level, and establish delivery systems. We will create the basis for
drug discovery research, and also promote research as the foundation for drug discovery withthe aim of developing therapeutic drugs for intractable diseases, such as cancer andneurological refractory diseases that target signal molecules. To start the project, we held akick-off meeting to which we invited Dr. Hachiro Sugimoto (Professor, Kyoto University
Graduate School of Pharmaceutical Sciences; former executive board member anddirector of Drug Discovery Research Laboratories I, Eisai Co., Ltd.) who developed
Aricept, a therapeutic drug for Alzheimer's disease and who is highly regarded
internationally, to give us a lecture on the theme of "the Long Road to Drug Discovery Pursuing the dream of development of a therapeutic drug for Alzheimer's disease." In
addition, project members attended a presentation to report the plan for promoting
research from this point and to report on its progress.

Funded Research Achievements• Pharmaceutical tests in the phase III clinical trials of famciclovir in the treatment of herpes
zoster• Action of prostaglandin D2 receptors (DP) on activity of the lymphocyte cholinergic system• Performance evaluation of the newly-developed HPLC column, and its application to real(clinical) samples• New medication methods for novel compounds and known compounds• Effects of MEK inhibitors on the expression of P-glycoproteins• Creation of novel anti-human urate transporter-1 (URAT1) antibodies• Idiosyncrasies of transporter inhibition, and the effects of these compounds on transporter
expression• Investigation of the social contribution of OTC pharmaceuticals• Regulation Mechanism of Natural Moisturing Factor Synthesis and Estrogen Metabolism in
Epidermis• Construction of Carbohydrate Antigens Toward the Diagnostic Drugs for Parasite Infection• Elucidation of P-glycoprotein molecular complex toward the discovery of tissue-selective
drug distribution promoters

Development of new treatments for intractable diseases based on
clarification of molecular mechanisms in response to stress(2005-2009 Research Representative: Professor Yoshikazu Sugimoto, Faculty of Pharmacy)
A stress response is a natural defense mechanism whereby a living organism protects
itself from various external stimuli. However, in recent years it has become clear thatproblems such as neurological disorders and allergic diseases can be caused by failure ofstress response mechanisms, or even by stress responses themselves. In cancer
treatments, the stress response of cancer cells leads to increased drug resistance andapoptosis resistance, so controlling the stress response of cancer cells is thought to be
essential for increasing the efficacy of cancer drug treatments. In this project, we haveelucidated from various viewpoints the biological stress response mechanisms in suchterms as oxidative stress, inflammation, allergies and reactions between cancer anddrugs. We have also evaluated the activities of 659 chemical compounds in 24 evaluation
systems for the purpose of developing new drugs that are effective in weakening or
modifying the stress response. The results of this project are expected to lead to thedevelopment of preventative medicines and the diagnostic methods and treatments fordiseases that are on the increase in our aging society, such as cancer, neurologicaldisorders, heart disease and allergic disease.

Links between industry, government and academia research examples
Ministry of the Environment: Development of an aqueouschromatography system with lower environmental impact
In this study, we developed a novel chromatography technique that uses noenvironmentally harmful organic solvents and requires no waste water treatment. We
also developed a sophisticated method for analyzing biological samples andenvironmental samples based on this chromatography technique. For five years from2005 to 2009, the National Institute for Environmental Studies and a group led byProfessor Hideko Kanazawa of the division of Physical Pharmaceutical Chemistrycontinued a study commissioned by the Ministry of the Environment. The initial objective of
this study, to establish environment methods of analysis that are environmental friendly, wasfully achieved.

Development of a aqueous chromatography system with
reduced environmental impact
Hydrophobic samples

Aging

Abnormality
Processing of APP
Metabolism/aggregation of Aß
Phosphorylation of tau protein

Abnormality

Abnormality

Local bloodflow in the cerebral
cortex

Cholinergic
neurons in thebasal forebrain

The triangle theory (left)
related to the progressof cognitive disorders,such as Alzheimer's
disease, and cholinergic
neurons in the basal
forebrain (right)

Establishment of efficient drug development method and side effectreduction method by analysis of factor that influences
pharmacokinetics(2007-2011 Research Representative: Professor Tadahiko Mashino, Faculty of Pharmacy)
It takes significant cost and time to develop drugs, and the success rate is very low. This ispartly due to the pharmacokinetics of candidate compounds, whereby candidates thatshow good activity in vitro often fail to result in useful drugs due to issues with their in vivo
kinetics. The side-effects and interactions of drugs are also closely related to their in vivo
kinetics. To address this issue, we aim to make drug development more efficient andreduce side-effects and drug interactions by developing methods for improving
pharmacokinetics by analyzing the two factors, "the chemical structure of candidate
compounds" and "the control of transporters and metabolic enzymes." In the search for
new drug candidate compounds, pharmacokinetic prediction systems are also being
developed, but these are passive predictions based on the analysis of prior data. We are
therefore actively analyzing factors that have pharmacokinetic effects by carrying out awideranging study including fields from organic chemistry, natural products chemistry,
molecular biology, analytic chemistry and clinical research, with the aim of providing the
precise control of in vitro kinetics.

Hydrophobic
Very weakinteraction

Hydrophobic
Elution accompanyinghydrophobic
interaction

Vitamin C60 BioResearch Corporation
The effects of the antioxidant, fullerenes, on inflammation andphysiological responses
Fullerenes exhibit various novel activities such as antioxidant activity, suppressive
effects on cancer cell proliferation and antiviral activity. These activities are being
clarified by the Division of Medicinal Chemistry, Graduate School of Pharmaceutical
Sciences, Keio University, and are being put to practical use in cosmetic products linked totheir antioxidative activity. In this funded research, we are studying the antiinflammatory effects as a new function of fullerenes, together with the venture business
Vitamin C60 BioResearch Corporation.

Antiviral activity
Antioxidative activity
Suppression of cancer cell proliferation

22

Shin-Kawasaki Town Campus

For Inquiries:

Research Centers

Shin-Kawasaki Town Campus
Open and Cutting-edge Research
Facility Pursuing IndustryGovernment-Academy-Region
Collaboration

Shin-Kawasaki Town Campus
Shin-Kawasaki Frontier Research and Education
Collaborative Square
7-1 Shin-Kawasaki, Saiwai-ku, Kawasaki, Kanagawa,
212-0032 Japan
TEL: +81-44-580-1580 FAX: +81-44-580-1570
http://www.k2.keio.ac.jp/
E-mail: k2-tc@adst.keio.ac.jp

The Shin-Kawasaki Town Campus, popularly known as K2 Town Campus, was established in the spring of 2000 as a facility responsible for cutting-edge joint researchamong industry, government, academy and region through collaboration and cooperation with Kawasaki city. K2 ("K Square") represents the double meaning of (1) Keio(one "K") and Kawasaki (another "K") teaming up and thereby producing a squared effect by joining forces, and (2) the campus square (plaza). Keio and Kawasaki city
signed a basic agreement in November 2009. In March 2010, the 10th year after its establishment, a new agreement was signed to promote the "Shin-Kawasaki Creative
Forest Project." K2 Town Campus is a leading-edge, collaborative, interdisciplinary research-oriented campus. With the three central tenets of "advancing leading-edge
research," "creating new industries and business," and "contributing to society and the community," we promote various research activities as a campus that paves theway to a new age.
Advancing Leading-edge Research
Currently, 14 research projects are being developed and about 400
registered researchers (including faculty members, joint researchersand postgraduate / undergraduate students) are carrying out
interdisciplinary research activities. In 2010, the Keio Photonics
Research Institute Funding Program for World-Leading Innovative R&D on
Science and Technology (FIRST Program) was started under Yasuhiro
Koike, Professor, Faculty of Science and Technology, as the project
leader.

Providing researchachievements
utilizing KBIC

Advancement ofleading-edge research

Creation of new
industries andbusinesses

Providing educational
opportunities such as
seminars and tours

Contributions tosociety andcommunity

Creating New Industries and Businesses
Corporate business networking events and similar events have been
held to further advance each research project and to achieve
collaboration with companies based on research results, with the aim ofcreating new industries and businesses.

(Partnering with Kawasaki City)

Contributing to Society and the Community
In partnership with Kawasaki city, we hold many events for community
residents and businesses, and provide learning opportunities
concerning science and technology. We also carry out workshops and onsite science learning for children in the community.

Creation of researchstronghold based on industrygovernment-academy-region
collaborations

Revitalizing local industries

Research Projects * Completed in FY2009 ** New Project starting in FY2010
K-Building

Project on Search and Development of Intriguing Chemicals for Health Foods
Daisuke Uemura (Professor, Faculty of Science and Technology)

E-Building

ERATO-SORST Koike Photonics Polymer Project
Yasuhiro Koike (Professor, Faculty of Science and Technology)

K-Building

New Generation Terabit Core/Access Network Research Project
Naoaki Yamanaka (Professor, Faculty of Science and Technology)

I-Building

High-Level Global Cooperation for Leading-Edge Platform on Access Spaces
Kouhei Ohnishi (Professor, Faculty of Science and Technology)

K-Building

Project on Advanced Light-Wave Control Technologies
Fumihiko Kannari (Professor, Faculty of Science and Technology)

O-Building

Next Generation Nano-technology Thin Film Project
Seimei Shiratori (Associate Professor, Faculty of Science and Technology)

K-Building

Technology of Air Cleaning for Creating the Comforts of Life
Shigeru Tanaka (Professor, Faculty of Science and Technology)

O-Building

WIDE Project
Jun Murai (Professor, Faculty of Environment and Information Studies)

K-Building

Project on Naturally Occurring Huge Molecules
Daisuke Uemura (Professor, Faculty of Science and Technology)

O-Building

Future Vehicle Project
Hiroshi Shimizu (Professor, Faculty of Environment and Information Studies)

K-Building

Keio Photonics Research InstituteFunding Program for World-Leading Innovative R&D on Science and Technology(FIRST Program)
Yasuhiro Koike (Professor, Faculty of Science and Technology)**

O-Building

Co-Mobility Society Creation Project
Katsuhiko Ogawa (Professor, Faculty of Environment and Information Studies)(Assumed the post in 2010)

K-Building
K-Building

Distributed Real-time Controlling ProjectNobuyuki Yamasaki (Associate Professor, Faculty of Science and Technology)

Project on Development of Integrated Communication Network Technology by
Visible Light Communication
Masao Nakagawa (Professor, Faculty of Science and Technology)*

K-Building

Research Project on Secure and Reliable System Software
Kenji Kono (Associate Professor, Faculty of Science and Technology)

Ultrabroad Femtosecond Ti:sapphire Oscillator

23

Exploring pharmaceutical resources from marineorganisms

Graded Index Plastic Optic Fiber (GI-POF)

Electric Vehicle, "Eliica"

Shin-Kawasaki Town Campus

Advancement of Leading-edge Research
The research projects described in the following are some representative examples of those currently being undertaken at K2 Town Campus.

Co-Mobility Society Creation Project
MEXT Special Coordination Funds for Promoting Science and Technology
Representative: Hironao Kawashima (Professor, Faculty of Science and Technology)
The "co-mobility society," namely, a creative and civilized society in which everyone from children to the elderly can move around freely and safely,intermingle easily, and live comfortably, is the target of this research project - which aims to create the social infrastructure for underpinning such a society.
This research is aiming to establish the "co-mobility society infrastructure" for linking the real and virtual worlds by means of expanding and integrating eachresearch theme around the three axes of "community science," "mobility science," and "human-harmony science," creating new hybrid communities, andpropagating these communities through society on a grand scale. Moreover, for application to the everyday world, several model districts were set up, andcooperative agreements were signed with Kurihara City, Miyagi in 2007, Okutama Town, Tokyo in October
2008, and Aomori city in February 2009.
In 2009, after strengthening the collaboration system with these local governments, we conducted many
demonstration experiments, such as the test operation and test driving of small electric vehicles with anauto-control function (see the photo at the right), the revitalization of downtown areas, the restoration of
information networks in the event of a disaster. The results of each demonstration experiment haveconsistently been successful up to 2010, the fourth year since research started. At the Co-Mobility Society
Research Center, which manages and controls this project, efforts are also being made for other projects,
such as the development of a system to provide a high-speed operating service, which is safe and securewith a small environmental burden.
Small Electric Vehicle with Auto-Control Function*Katsuhiko Ogawa (Professor, Faculty of Environment and Information Studies) took over the role of representative for this project in 2010.

High-Level Global Cooperation for Leading-Edge Platform for Access Spaces
MEXT Global COE Program
Representative: Kouhei Ohnishi (Professor, Graduate School of Science and Technology)
To develop a world-wide stronghold for global research cooperation, at Shin-Kawasaki Town Campus,
Building I, about 100 affiliated researchers (including research assistants) are involved in cutting-edge
research activities on the following four projects: (P1) Basic engineering physics for innovative
photonic/electronic device creation; (P2) Environment- embedded device technology; (P3) Real-world andreal-time network for multi-dimensional processing and communication; and (P4) Perception andexpression technology.
On November 13, 2009, at the Shin-Kawasaki Town Campus, we held the 2nd Global COE PhD Forum tostrengthen exchanges with industry. The event was attended by officials from the Ministry of Economy,
Trade and Industry, and many researchers and technicians working in the area of robot engineering/media
engineering from companies with closely related technologies. Young researchers presented the latest
research results.
*For more details of activities for this project, see the lower portion of page 29.

Creation of New Industries and Businesses

A scene on the day of the PhD ForumContributions to Society and Community

Business Fellowship Event
At the business networking event, fourdemonstrations on visible light were held, andattendees centered around company
researchers were engaged in discussions on
the creation of new things (monozukuri) andthe possibility of new businesses, centeredaround company researchers.

Seminar for Children
We held two events in which children could
actually experience the enjoyment of science.

Date: March 3, 2010
Venue: Nakagawa Research Laboratory,
Demonstration
facilitated by Shinichiro Haruyama, Professor,
Graduate School of System Design and Management

Open Campus
All projects were made public. A great manymembers of the public, students, andcompany employees came to the meeting.
Date: November 14, 2009

"Let's see the total solar eclipse"
Date: July 22, 2009
"A Happy Day of Playing with Science"
Date: September 26, 2009

Kawasaki Business Incubation Center (KBIC)
The Kawasaki Business Incubation Center(KBIC) is an incubation facility that was built
adjacent to the campus by Kawasaki city.
The Center is currently engaged in sevenresearch projects, including researchlaboratories that have already beencommercialized, with the aim of achieving
commercialization and creating new businessstart-ups based on the research results.
Kawasaki Business Incubation Center

Workshop for children

A scene at the open seminar

Open Seminar
As a cooperative project with Kawasaki city, three open seminars were held in which
cutting-edge technologies were presented to members of the public as well as company
employees and agency representatives.
1st seminar: November 14, 2009 "Toward Face-to-Face Communication"
Lecturer: Yasuhiro Koike, Professor, Faculty of Science and Technology
2nd seminar: November 14, 2009 "Future Electric Vehicles"
Lecturer: Hiroshi Shimizu, Professor, Faculty of Environment and Information Studies
3rd seminar: March 3, 2010 "Advanced Technologies of Visible Light Communication and Its
Application"
Lecturer: Shinichiro Haruyama, Professor, Graduate School of System Design and Management

24

Tsuruoka Town Campus

For Inquiries:

Research Centers

Tsuruoka Town Campus
The World's Leading Pioneer in
Integrative Systems Biology

In April 2001, Keio University established Tsuruoka Town Campus of Keio (TTCK) in Tsuruoka City,
Yamagata Prefecture, with the cooperation of Yamagata Prefecture and the municipalities of Shonai
region. The cornerstone of the campus is the Institute for Advanced Biosciences (IAB).
Research at IAB is conducted at two facilities: the Campus Center and the Bio-lab.
TTCK conducts, closely and jointly with the other campuses of Keio, research and development inadvanced areas and enhances research and educational activities. It proactively transfers newly createdtechnologies to local governments and businesses to encourage industry-government-academia
collaboration, for contributing to regional development as well as to the advancement of science andtechnology in Japan.

Tsuruoka Town Campus
Keio Frontier Research & Education Collaborative
Square at Tsuruoka
14-1 Baba-cho, Tsuruoka-shi, Yamagata, 997-0035 Japan
TEL: +81-235-29-0800 (Main) FAX: +81-235-29-0809
http://www.ttck.keio.ac.jp/
E-mail: office@ttck.keio.ac.jp

Bio-labInstitute for Advanced Biosciences (IAB)The Institute for Advanced Biosciences (IAB), Keio University, located in Tsuruoka city, Yamagata prefecture, is recognized as a world pioneer in integrated
systems biology, a new approach to bioscience of the 21st century.
Having developed leading-edge biotechnologies, we measure and analyze the cellular and metabolic activities of human and other organisms including microbes, try
to understand various cellular functions and physiological activities using computer simulations, and apply their findings to medical, environmental, and foodsciences.
http://www.iab.keio.ac.jp/

Major Research Projects
Cabinet Office, Government of Japan•Super Special Consortium for Supporting the Development of Cutting-edge Medical•Care•“Project of Early Clinical Development for Anti Cancer Medicine and Device” (2008-2012)
Ministry of Education, Culture, Sports, Science and Technology (MEXT)•Global COE Program•“Global COE for Human Metabolomic Systems Biology” (2007-2011)•City Area Program•“Project for creation of high-functional food science industry cluster” (2009-2011)
Ministry of Health, Labour and Welfare•Health and Labour Science Research Grants•Research on the Risk of Chemical Substances:•“Research related to the development of methods for evaluating the harmfulness of chemical•substances using metabolome analysis and biomarkers”(2007-2009)•Health and Labour Science Research Grants•Research into Biological Markers for New Drug Development•“Biomarker discovery of drug induced hepatitis by global analysis of intracellular molecules”•(2008-2012)•Grant-in-Aid for Cancer Research•“Establishment of evaluation systems for therapeutic approaches utilizing cancer-specific•biological processes” (2009-2011)
New Energy and Industrial Technology Development Organization (NEDO)•Functional RNA Project•“Analysis of the functions of functional RNA”(2005-2009)
Japan Science and Technology Agency (JST)•Basic Research Programs (PRESTO)•“Development of ultramicro-electrospray ionization approaches for -omics research”•(2006-2009)•Bioinformatics Operations•“Development of Metabolome MS Spectral Integration Database” (2006-2010)•Comprehensive Support Programs for Creation of Regional Innovation Science and•Technology Incubation Program in Advanced Regions (Promotion Research)•“Protein phosphorylation display for drug discovery and diagnosis” (2008-2010)
Yamagata Prefecture and Tsuruoka City•"Development of Fundamental Technologies Using Systems Biology (Simulations Software•Techniques, Metabolome Analysis Techniques, Genome Design Techniques, Proteome•Analysis Techniques) and Their Applications (Medical, Food, and Environment)" (2006-2010)25

Research System
Major Joint Research Organizations:
The Faculty of Science and Technology, the School of Medicine, Shonan
Fujisawa Campus, RIKEN Japan, Human Metabolome Technologies, Inc.,
BioSigma S.A. (Chile), Denso Corporation, Kirin Holdings Company, Limited,
Kao Corporation

Educational Activities
The IAB develops and deploys educational activities for students with different
majors in undergraduate or graduate school at Keio University under the ideal that
advanced research and education should be inseparable. In FY2009, 40
students in the spring semester and 40 students in the fall semester
participated in the programs and activities offered at TTCK.
Bio Camp
The Bio Camp is a program for students of the Shonan Fujisawa Campus (SFC) of
Keio to spend two semesters (or one semester) at the TTCK and experience thebasics of biotechnology. The program begins with an introduction to thehandling of laboratory instruments because the students have no experience withexperiments. Each student extracts Human DNA and analyzes the gene foralcohol-degrading enzymes, and diagnoses through genetic testing level oftolerance for alcohol is high or low. At the end, the students decode thegenome sequences through state-of-the-art DNA sequencers.
Systems Biology ProgramThis Program is a rare graduate program in the world in the sense thatstudents can earn credits using the abundant research resources of both the SFC(bioinformatics) and IAB (Systems Biology). At TTCK, a number of experiments andlaboratory trainings are provided, such as "metabolome analysis" and"proteome analysis," using the most advanced DNA sequencers, bioreactors, and
CE-MS equipment.

Tsuruoka Town Campus

EventsIntroduction to Bioscience for Tsuruoka Citizens
The introductory bioscience course for general public and taught byresearchers of the IAB. There were 99 participants in FY2009.
Summer Bio College
This is a basic hands-on program in
biotechnology aimed at high school
students in the Keio's affiliated highschools. There were 16 participants in
FY2009.
Bio College of Summer
Keio Summer Bio CampThis is a basic hands-on program in biotechnology for any high school students
from all over Japan. There were 13 participants in FY2009.

Spring Science CampThis is a basic hands-on program in biotechnology for any high school students
from all over Japan. (Sponsored by: Japan Science and Technology Agency)
There were 16 participants in FY2009.

Commercialization
A Bio-Venture Company from Keio University
Human Metabolome Technologies, Inc. (HMT)
Human Metabolome Technologies, Inc. (HMT) is a venture company
established in July 2003 by Professor Masaru Tomita, Professor Tomoyoshi
Soga, and others from the IAB. HMT is based on the IAB's measurement andanalysis technology for metabolomes (all intracellular metabolites). HMT
conducts R&D aimed at industrial applications in medical care, drug discovery
and food fermentation, etc.
In October 2003, HMT became the first company to attract investment from theEntrepreneur Assistant Fund of Keio University. HMT has realized cost
reductions for custom metabolomes analysis by automating the analyticalprocess. In addition to broadening the custom base for pharmaceuticals,
chemistry, and the food industry, HMT is advancing the exploratory research
into disease biomarkers in the areas of mental and lifestyle diseases bycooperative research in association with public institutions and other entities.
http://humanmetabolome.com/
Spiber, Inc.
A bio-venture company from Keio University which was founded by IAB
graduate students, etc. in 2007 based on the spider silk artificial
synthesis/production technology which was carried forward at this laboratory.
Toward the world's first practical application of spider silk which is said to bea dream fiber material, the company was established with the mission ofmoving away from oil in the textile industry. The company is sponsored by Keio
University.
At the 9th Japan Biotechnology Business Technology Competition, thecompany won the first highest award as students, and was also selected for
top 20 Most Promising University-based Startups (announced by the Ministryof Economy, Trade and Industry). The company's strength is a platform forconsistent material development from design to synthesis and fiber production
technologies for spider silk-based biomaterials that make optimum use of
bioinformatics. Based on its strength, the company is progressing with R&D
with the aim of creating new materials and finding practical application incollaboration with major manufacturers.
http://www.spiber.jp /High-throughput and quantitative CE-MS methods that can measure thousands of charged
intracellular metabolites. This is a powerful new device for metabolome research developedby IAB.

Other Related Facilities
Tsuruoka Metabolome Campus was founded in 2005 as a research facility by
Tsuruoka City which aims at cluster formation of bioresearch and developmentwith IAB as its cornerstone. In addition to IAB's Metabolome group, Human
Metabolome Technologies Inc., RIKEN Japan, School of Medicine, Keio
University, NISHIKAWA KEISOKU Co., Ltd., BioSigma S.A. (Chile), and Spiber Inc.
are on the campus conducting research.

Major Awards
November 2001
"Yamagata Keizai Doyukai (Association of Corporate Executives) Grand Prize, Yamagata
Landscape Design Award"
June 2003"Nihon Kogyo Shimbunsha Award in the 17th Dokusousei wo Kirihiraku Sentan Gijutu Taishou(Leading-edge Technology for Originality and Creativity)"
November 2003
"IBM Shared University Research Award"
June 2004"Industry-Academia-Government Collaborative Distinguished Service Commendation(Award of the Minister of State for Science and Technology Policy)"
April 2005
"First Prize in the 5th Japan Biotechnology Business Competition"
April 2007
"Prize for Science and Technology in the Commendation for Science and Technology
by the Minister of Education, Culture, Sports, Science, and Technology"
April 2009"19th Nikkei BP Technology Award, Category of Medicine & Biotechnology"
July 2009"2009 The Prize of the Chairman of Hatsumei Kyokai (Japan Institute of Invention andInnovation)"

Tsuruoka Metabolome Campus

September 2009
"Award for Distinguished Service to the Metabolomics Society"26

Introduction to Publicly Funded Research
In recent years, Keio University has had an excellent record of accomplishment in obtaining the following prominent competitive research grants. Both theeducational research activities and the research results supported by these grants have been highly regarded in Japan and abroad.

Global COE Program
Out of its original 12 programs that were established under the "21st Century Center of Excellence (COE) project," a government-sponsored initiative to develop advanced
research centers at Japanese universities, Keio University is currently operating seven Global COE programs. These programs set up individual research and education"hubs" in Keio University's Advanced Research Centers, that are flexible and maneuverable interdisciplinary organizations transcending the boundaries set by faculties
and graduate courses. In each of these programs, dovetailing with existing education and research platforms, internationally distinguished research andeducation centers are created through the strengthening and enhancement of the education and research functions of Keio's graduate school, and processes to foster
the development of young researchers have been established. By doing so, Keio is moving forward to create a university that meets the highest global standards.
Centers Selected in the Global COE Program
Page

Adopted Year

Field

Home Campus＊

Program Title

Program Leader

P.29

2007

Life sciences

Shinanomachi

Global COE for Human Metabolomic Systems Biology

Makoto Suematsu, Professor, Graduate School of Medicine

P.29

2007

Information sciences, electrical andelectronic sciences

YagamiHigh-Level Global Cooperation for Leading-Edge Platform on Access Spaces (GCOE)

Kouhei Ohnishi, Professor, School of Science and Technology

P.30

2007

Humanities

Mita

Center for Advanced Research on Logic and Sensitivity

Shigeru Watanabe, Professor, Graduate School of Human Relations

P.30

2008

Medical sciences

Shinanomachi

Education and Research Center for Stem Cell Medicine

Hideyuki Okano, Professor, Graduate School of Medicine

P.31

2008

Mechanical, civil engineering, architectural
Yagami, Hiyoshi
and other fields of engineering

Center for Education and Research of Symbiotic, Safe and Secure System Design

Takashi Maeno, Professor, Graduate School of System Design and Management

P.31

2008

Social sciences

Mita

Raising Market Quality - Integrated Design of Market Infrastructure

Naoyuki Yoshino, Professor, Graduate School of Economics

P.32

2008

Social sciences

Mita

Designing Governance for Civil Societies

Yoshihisa Hagiwara, Professor, Graduate School of Law*Home Campus: Affiliate Campus of research representative

Special Coordination Fund for the Promotion of Science and Technology
The Special Coordination Fund for the Promotion of Science and Technology refers to expenses for comprehensively accelerating and adjusting importantmatters necessary for the promotion of science and technology in accordance with the plans and objectives of the Council for Science and Technology Policy. In linewith the three policies shown below, the funds provided are used for policy-directed research projects that have a high degree of effectiveness. The funds
support projects such as the following: projects that relate to government ministry policy initiatives; boundary projects that cannot be covered by the policies of eachministry; projects from which the benefits of synergy can be expected due to inter-agency cooperation; and projects that require a flexible approach.
(1) Reform of scientific and technical systems to create and implement superior results,(2) Strategic response to emerging, promising research areas, and(3) Promotion of the internationalization of scientific and technical activities.
Concerning the specific methods of using the funds, the Council for Science and Technology Policy creates budget request policies and basic policies forallocating the funds, MEXT uses the funds for such activities as public offering, review, fund allocation, interim/after-the-fact assessments, etc. in line with these policies.
In 2009, Keio University received subsidies for five themes as work-in-progress research.
Research in Progress from 2009
Affiliation

Position

Project Leader

ProgramResearch Theme

Faculty of Science and Technology,
Faculty of Environment and Information Studies,and Graduate School of Media and Governance

Professor

Hironao Kawashima

Creating of Innovation Centers for Advanced
Interdisciplinary Research

Creating a Co-mobility Society*

Faculty of Environment andInformation Studies

Professor

Masataka Watanabe

Promotion of International Joint Research

Development of Environmental Resources Management Technology for
Sustainable Use of Biomass

School of Medicine

Professor

Toshio Suda

Improvement of Research Environment for
Young Researchers

Career Development Program for Young Investigators in "Cell andMetabolism Research" (Keio Kanrinmaru Project)*

School of Medicine

Professor

Koichi Matsuo

Encouraging Innovative and Creative Young
Researchers

Medical Biologist Support (MEBIOS) Training Program*

Faculty of Nursing and Medical Care

Professor

Kikuko Ota

Developing Models for Supporting Woman
Researchers

Project for Developing Social Capital and a Good Working Environment for
Women Researchers**The University President has final responsibility for these research projects.

JST Basic Research Programs
JST Basic Research Programs are handled by the Japan Science and Technology Agency (JST). In sponsoring these programs, the Agency takes a top-down approachin promoting target-oriented basic research directed toward the achievement of national government objectives. The purpose of these programs is to create the seedsof new technologies for responding to social and industrial needs and generating future scientific and technical innovation. The key persons in these programs areresearchers from universities, public agencies, and private corporations, and they carry out research through formation of flexible, mobile cross-organizational research
project teams that disband upon completion of the project. This system of directed research programs contrasts with the characteristics of funding for bottom-up
scientific research that places a high value on the proposals of individual researchers. These two systems, like the two wheels of a cart, are designed to play a majorrole in promoting Japan's science and technology from different aspects. JST establishes specific areas of research, based on the strategic objectives of MEXT. Under
the leadership of its research directors, JST brings together researchers from industry, government and academia, and sets up the most appropriate researchorganization.
Two major types of research are promoted at JST: open research and JST-supervised research. In open research, a JST-designated research director calls for
submission of research proposals in a research area specified by the JST, selects proposals, and promotes the work of the selected researchers. Open research are
categorized into two types: team research, called CREST (Core Research for Evolutional Science and Technology), and individual research, for path-breaking work
to be done by individual scientists.
In supervised research called ERATO (Exploratory Research for Advanced Technology), the research targets are based on the unique perspectives of JST's
research directors. Based on these targets, researchers are brought together to engage in the projects. The ERATO research also includes joint research with overseas
research organizations.

27

CREST Research Representatives
Affiliation

Position

Name

Research Theme

Graduate School of Media Design

Professor

Masahiko Inakage

The Research of Ubiquitous Content Production Authoring System

Graduate School of Media Design

Professor in special
research

Susumu Tachi

Construction and Utilization of Human-harmonized "Tangible" Information Environment

Faculty of Science and Technology

Professor

Tadahiro Kuroda

Generation of High-performance, Ultra-low-power, Short-range Wireless Mobile Information System

Faculty of Science and Technology.
Faculty of Science and Technology

Professor

Hideo Saito

Technology to Draw Three-Dimensional Contents in Free Space

Associate Professor

Nobuyuki Yamasaki

Research and Development of Dependable SoC and Dependable OS

Faculty of Science and Technology

Associate Professor

Kenji Kono

Producing Highly Attack-resistant Secure Operating Systems

School of Medicine

Professor

Michisuke YuzakiRole of C1q Family Signaling in Regulation of Synapse Formation in the Mature Brain

School of Medicine

Professor

Toshio Suda

Metabolism in Hematopoietic Stem Cells

School of Medicine

Professor

Hideyuki Saya

Analysis of Abnormal Regulation of Cell Differentiation and Drug Development Research by Using Induced
Cancer Stem Cells

School of Medicine

Professor

Akihiko Yoshimura

Reprogramming of Immune System by Modulation of Intracellular Signal Transduction

School of Medicine

Associate Professor

Mikiko C. Siomi

Regulation of Gene Expression Mediated by RNA Silencing

Faculty of Environment and Information Studies

Professor

Masaru Tomita

Development of Modeling/Simulation Environment for Systems Biology

Faculty of Environment and Information Studies

Professor

Hideyuki Tokuda

A Dependable Operating System for Micro Ubiquitous Nodes

Affiliation

Position

Name

Research Theme

Faculty of Science and Technology

Assistant Professor

Akinobu Yamaguchi

Study in Novel Electromagnetic Properties of Modulated and/or Periodic Magnetic Structure Composed of
Nanoscale Magnets

School of Medicine

Assistant Professor

Motoaki Sano

Metabolomic Analysis of Heart Failure and Cardiac Senescence

School of Medicine

Instructor

Go Nagamatsu

Establishment of Novel Reprogramming Methods Based on Germ Cell Specificity

School of Medicine.
School of Medicine

Associate Professor

Takeshi Miyamoto

Regulation of Bone Metabolism through Osteoclast Cell-cell Fusion

Assistant Professor

Takeshi Kawauchi

Elucidation of Roles of Intercellular Functional Domain in Formation of the Cerebral Cortex

School of Medicine

Research Associate

Kyoko ShirakabePhysiological Roles and Regulatory Mechanism of Ectodomain in Shedding in Innate Immune Response

Faculty of Environment and Information Studies

Associate Professor

Yasuto Nakanishi

A Design and Development Support System for Spatial Information Systems

Faculty of Environment and Information Studies

Assistant Professor

Yasuaki Kakehi

Creation of Real-World Oriented Interactive Media for Artistic Expression

Associate Professor

Yasushi Ishihama

Development of Ultramicro-electrospray Ionization Approaches for -Omics Research

Affiliation

Position

Name

Research Theme

School of Medicine

Professor

Hideyuki Okano

Nerve Regeneration Strategy Based on Endogenous Neural Stem Cell Activation

Faculty of Science and Technology

Professor

Yasuhiro Koike

Photonics Polymers for Fiber to the Display

Faculty of Pharmacy

Professor

Takeshi Sugai

Synthesis and Utilization of Heterochiral Synthons based on Biocatalytic Transformations

PRESTO Researchers

Graduate School of Media and Governance

SORST Researchers*JST: From the Basic Research Programs website http://www.jst.go.jp/kisoken/ *The list above shows research themes continuing since FY2009.
*SORST refers to a project that has completed its initial period of examination under the Basic Research Programs and that is continuing because it is regarded as having great potential for future benefits and expansion.

Grants-in-Aid for Scientific Research (Kakenhi)
Kakenhi or grants-in-aid for Scientific Research of MEXT, are subsidies for research in all areas of inquiry, from thehumanities and social sciences to the natural sciences. Grant money is given to various kinds of academic
research, from basic to applied. From research based on the free, inventive thinking of researchers, the grants aim togenerate results that will bring about social breakthroughs. Over the years, many research projects conductedunder these grants-in-aid, have achieved results of the highest order and have received worldwide recognition,from Nobel Prizes to other awards for scientific endeavor given in Japan and overseas. The program makes use of
approximately six thousand judges to carry out peer review of the proposals submitted. Projects chosen every year areof all kinds, from those in the incubation stage to those at the cutting edge in their field. The Kakenhi program
represents approximately 5% of the government's total expenses related to science and technology and 40% of thegovernment's total budget for competitive research funds.
About 138,000 applications were submitted in FY2009. Among these, about 59,000 applications qualified for researchfunding, and the total amount (in direct expenses) was about 158,400 million yen. The table shows the number of projects
for the top twenty institutions receiving grants (new and those continuing from the previous year) in FY2009 and the total
amount distributed. The amount received by the top 10 institutions represents about 44% of the total amount
distributed. Looking at the number of projects, in FY2009, Keio University ranked 10th overall (first among private
institutions), an improvement on the rank in the preceding FY 2008.
A: Total amount distributed (research expenses) B: Total of the top 10 institutions C: Total of the top 20 institutions* Source: Japan Society for the Promotion of Science, http://www.jsps.go.jp/* The amount distributed includes direct and indirect expenses.
* The figures are rounded off to the nearest 100,000 yen.
* Data here is classified by the research institution with which the research representative is affiliated; it may not reflect the overall ranking by institution.

FY2009 Kakenhi Distributed by Institution
Rank

Institution

01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
A
B
B/A
C
C/A

University of Tokyo
Kyoto University
Osaka University
Tohoku University
Kyushu University
Hokkaido University
Nagoya University
University of Tsukuba
Hiroshima University
Keio University
Kobe University
Tokyo Institute of Technology
RIKEN Japan
Okayama University
Chiba University
Waseda University
Kanazawa University
Niigata University
Kumamoto University
Nagasaki University

Number of
Projects

Amount(Million yen)

3,090
2,403
2,016
1,969
1,480
1,390
1,331
970
868
749
735
707
665
636
621
620
563
478
463
434

24,493
14,164
10,61910,411
6,056
5,947
6,333
3,602
2,646
2,941
2,714
4,692
3,949
1,946
2,200
2,155
1,629
1,349
1,525
1,141
197,000
87,211
44%
110,51156%

Health Labour Sciences Research Grant
The public administration of health, labour and welfare is essential in dealing appropriately with the aging of the population, which is resulting from the decline in the birthrate, changes
in the types and incidence of diseases, changes in the social environment, the diversification and sophistication of public needs, etc. Administrative measures need to be based on
appropriate and proper scientific grounds. For this reason, it is necessary not only to conduct research at national research institutes, etc. under the jurisdiction of the Ministry of
Health, Labour and Welfare, but also to create new knowledge through cooperation among various areas in industry, government and academia. Health Labour Sciences
Research is the general term for MHLW research conducted for these purposes.
The Health Labour Sciences Research projects consist of 17 projects in four areas: administrative policy research, basic health sciences research, anti-disease/disorderresearch, and health/security comprehensive research. Taking into account the opinions of external experts, administrative requirements, etc., targeted research themes are established
to resolve issues through research projects in public healthcare, welfare, life hygiene, workplace safety/hygiene, etc. On that basis, research themes and research groups are invited
through public offering, and are decided through evaluation by the evaluation committee. At Keio University in FY2009, there were a total of 159 projects adopted, including
grants-in-aid and contribution arrangements, accounting for a total of about 1.05 billion yen.
* Source: Ministry of Health, Labour and Welfare: http://www.mhlw.go.jp/bunya/kenkyuujigyou/index.html

28

Global COE Program [Life Sciences] FY2007

Center for Human Metabolomic Systems Biology
Program Leader: Makoto Suematsu (Professor, Graduate School of Medicine)
http://www.gcoe-metabo.keio.ac.jp/
This program is promoting "in vivo human metabolomic systems biology" in which the subjects ofresearch in metabolomic systems biology are specialized into revealing regulatory mechanism forphysiologic and pathologic conditions in humans. We aim to create a center forinterdisciplinary educational research at the highest level in the world to nurture young
scientists who create new life science research that represents the fusion of medical sciences,science and engineering, information sciences, pharmaceutical sciences and so forth. The
main achievements in FY2009 were as follows:
Promotion of Exchange Projects with Overseas Collaborative Organizations
In relation to our objective to conduct all graduate school lectures in English, in which we havebeen engaged since FY2008, we held the Spring School with Karolinska Institute (hereinafter, "KI").
Four RAs, selected on basis of their English-language ability and achievements, participated in the
School. The Spring School featured for the first time the credit transfer for the doctoral course, andthese four RAs received a certificate from KI.
Promotion of Interdisciplinary Fusional Research Utilizing Humanized Animal Model
Platform
Using various humanized animal models that have been developed since the start of the
program in FY2007, we have been conducting research into metabolic systems in relation to theitems shown below, and have been promoting projects through our inter-disciplinary researchacross four research clusters, namely, (1) analysis of bio-defense system metabolism, (2)development of in vivo models, (3) analysis of the metabolic network, and (4) analysis of celldifferentiation/metabolism regulations.
1. Analysis of in vivo cancer metabolic pathways by using human tumor-bearing NOG mice.
2. Metabolic properties of organ-specific metabolic regulatory molecules (HIF, aldehyde
dehydrogenase, various gas mediator receptors, etc.) were analyzed in knockout mice, and new
regulatory mechanisms of related metabolic systems were elucidated.
3. Receptors of CO, a gas molecule which increases through ischemia and oxidative stress,
were searched for by metabolomic analysis, and it was elucidated that cystathionine ßsynthase is a receptor of CO in mammals.
4. Experiments were conducted for the analysis of the properties of sulfur amino acidmetabolism / energy metabolism in a host-parasite a model of Entamoeba histolytica, and a necysteine metabolic pathway was discovered.
5. Viral regions responsible for abnormal glucose metabolism and abnormal iron metabolism thatare said to occur easily in humans through the action of the hepatitis C virus were searched forusing the in vitro virus method. The relationship between hepatitis C and abnormal lipid
metabolism was elucidated through an experiment involving HCV replicon proliferation.
6. A model that reproduces the human liver cell for an extended period in the mouse liver was
created for the first time in the world.
7. A quantitative evaluation system to elucidate the anatomical relationship between
abnormal energy metabolism and oxygen supply in low-oxygen pathological conditions wasestablished by using a multi-functional microscope system that enables the real-timemonitoring of energy metabolism and cellular behavior in the brain microcirculation of mice,marmoset monkeys and other animals.
8. Continued implementation of the developmental engineering research that contributes tothe development of Down's syndrome animal models using marmoset monkeys.

Spring School held at Karolinska Institute (March 2009)

Global COE Program [Information Sciences, Electrical and Electronic Sciences] FY2007

High-Level Global Cooperation for Leading-Edge Platform on Access Spaces
Program Leader: Kouhei Ohnishi (Professor, Graduate School of Science and Technology)
http://www.gcoee.keio.ac.jp/
This GCOE Program is creating an outstanding international research and education centerwith the aim of producing scientists and engineers who have rich humanity tendencies and theability to take an active role on the international stage. On the research front, we are pursuing new
human-centric science and technology to provide digital support that meets the needs ofparticular activities. We are making progress in coordinated research that integrates areasfrom photonic/electronic devices to network communication and haptics. Specifically, toprovide advanced human support in access spaces, we are pursuing research that heightens thebenefits of synergy in the following four fields: Basic engineering physics for innovative
photonic/electronic device creation, environment-embedded device technology, real-world and realtime networks for multi-dimensional processing and communication, and perception andexpression technology. Concerning human development, we are cultivating scientists andengineers who can assume an active role as leader on the international stage throughadvanced programs such as the double supervisor system (an educational system by multiple
supervising professors, including instructors at overseas partner and collaborator sites) and a joint
research promotional overseas dispatch system. As of FY2009, we have employed 74 COE
research assistants (RAs) who are registered as doctoral students and 13 post-doctoral fellows(PDs) under the competitive scheme, and cultivated them through our activities.

events included Keio Techno-Mall (December 2009), the PhD student paper contest and the
GCOE symposium (both in March 2010).

Specific Achievements in FY2009(1) Strengthening international collaboration
The number of international partner institutions increased by 13 to reach 52. In the fiscal year,
advanced collaborative activities such as joint research were conducted with 29 institutions.
Specifically, we held six workshops jointly with Xi'an Jiaotong University (China), theUniversity of Sydney (Australia) and other overseas institutions. In addition, 12 RAs were sent topartner institutions, such as Technische Universität München, Queen's University and Ghent
University in order to advance our joint research into haptics, nanotechnology, network
technology and other fields. Furthermore, under the double supervisor system, five RAs
obtained their degrees by receiving supervision from instructors at the University of London,
Harvard University, and elsewhere.

We intend to continue to intensively engage in our activities in the next fiscal year.

(2) Presentation of information to and exchanges with society and industry
We invited researchers and engineers from various companies, and held three PhD forums in which
RAs reported their research results, thereby enhancing exchanges with industry. We held
several events in which young researchers presented the results of their endeavors. These

29(3) Research achievements
We are producing many solid research results, including 191 journal papers, 31 invited talks, and306 presentations at international conferences.
The main results are as follows:• Low-density quantum dots for quantum cryptographic communication was successfully
created through joint research with ECL in France.
• 128-die NAND-flash memory stacking was achieved for the first time in the world by using
wireless inter-chip communication utilizing inductive coupling.
• A press release was issued regarding the results of the research on the access system using
an ultrafast PLZT optical switch, which was jointly developed through a start-up company in
the United States.
• Research into bilateral control technology for haptic sense and media expression technology
using mixed reality were conducted, and the access spaces using perception and expression
media were increasingly sophisticated.

Panel discussion in English at the Winter Camp

Joint research with the Queen's University (in UK)

Global COE Program [Humanities] FY2007

Centre for Advanced Research on Logic and Sensibility
Program Leader: Shigeru Watanabe (Professor, Graduate School of Human Relations)
http://www.carls.keio.ac.jp/english/
Under the Global COE Program, we are striving to fully understand the integration of logic andsensibility from the most basic biological level to the cultural level. Specifically, we are trying toclarify the following five points: (1) the biological bases for logic and sensibility; (2) genes anddevelopmental changes in logic and sensibility, (3) relationship between cognition/language andlogic/sensibility, (4) logic and sensibility in philosophy/aesthetics and their cultural
constraints, and (5) logical expression of logic and sensibility. In addition, through research
into these areas, we are cultivating humanities researchers with experimental techniques andexperimental researchers with humanities-based intelligence.
Research Achievements this fiscal year
We achieved some important research results this fiscal year, too. One achievement was
improvement of the time-resolution of functional magnetic resonance imaging (fMRI). We
successfully achieved a time-resolution at the level of 100 msec through joint research withProfessor Seiji Ogawa (advisor for this center). We pioneered a new area calledpharmacological NIRS in collaboration with Boehringer Ingelheim Co., Ltd. This fiscal year, weestablished a method for testing cognitive safety in children by making optimum use of the noninvasiveness and low-restrictive features of NIRS. In other experiments by the NIRS, it was
revealed that there were no differences in the brain response between the mother language andnon-mother language in newborn infants, whereas a left-dominant brain response that isstronger to the mother language is exhibited by in children at the age of four months. And an
experiment using TMS revealed that when part of the brain is suppressed, priority is given to themeaning of the conclusion of logical inference, and when other part is suppressed, priority is given
to the inference per se. In the research on aesthetics, research results on shadows in painting werecompiled and published as a paper. From an animal experiment, it was reported that thepigeon can differentiate between good and bad paintings drawn by children. This research wascovered by many media outlets overseas.
Nurturing of Human Resources
Nurturing of young scientists is an important issue for the center. At the center, we haveengaged the services of 10 research instructors and 17 researchers, with the new addition of one
assistant professor and eleven researchers (including foreign researchers) throughinternational public recruitment. In addition, nine people have completed a project course in which
participation in research at the center counts as a credit for graduate students.
Internationalization
International collaboration is important along with the nurturing of human resources. In this fiscal
year, we signed a new collaborative agreement with McGill University to bring the number ofoverseas collaborative institutions to eight. We have been periodically holding joint seminars foryoung researchers with University of Cambridge, the University of South Florida and Gachon
University of Medicine and Science. Program leaders conducted intensive university courses
overseas at Bielefeld University and Ecole Normale Superieure. And the project leader was
invited by the Chinese Academy of Sciences to give a lecture.
Domestic Collaboration
We cannot underestimate our domestic networks. We formed the "Global COE Network of
Mind Research" in collaboration with five centers of Global COE for the mind at otheruniversities, and held a joint symposium at the annual meeting of the Japanese Psychological
Association. This network aims at the establishment of an all-Japan system for the world's mostadvanced mind researches.
Public Relations Activities
During this fiscal year, we published four newsletters, and improved the content on our
website. We were also able to publish the third edition of our research results. In addition, we heldopen symposiums for the general public and, in particular, enjoyed the participation of large
audiences for topics related to English education.
Interim Evaluation
We had an interim evaluation this fiscal year. We were able to receive a high evaluation. We are
grateful to people who have supported the center.

Global COE Program [Medical Sciences] FY2008

Education and Research Center for Stem Cell Medicine
Program Leader: Hideyuki Okano (Professor, Graduate School of Medicine)
http://www.gcoe-stemcell.keio.ac.jp/
Since FY2008, the continuous aim of our GCOE Program, "The Education and Research Center for
Stem Cell Medicine," has been to establish a new academic domain that should be called"stem cell medicine." On the model of the nature of stem cells, this group has formed thecenter for education and research characterized by a continuous education system through thereorganization of the Graduate School of Medicine (self-renewal capacity), the nurturing ofmany different types of human resources who have the ability for international leadership(multipotency), and the exchange of human resources to establish an international
collaborative system (migration capacity). We are progressing the project with the aim of
producing many young scientists who, at the end of the program, will become international leaders
in stem cell research. This program consists of the following five subgroups consisting ofseveral persons in charge of promoting the project:
1. Regulation of somatic stem cell and in vivo experimental medicine;
2. Inflammation/immunological control and tissue regeneration;
3. Development of new therapeutic methods for cancers targeting cancer stem cells and EMT
3.(epithelial mesenchymal transition) ;4. Development of regenerative medicine for intractable diseases; and5. Practical implementation of feasible regenerative medicine.
The subgroups are engaged in their own pioneering research in active mutual collaboration.
FY2009, the second year of the program, was actually a year that yielded a large number of
research results. Many of academic papers released from this group were published ininternationally renowned journals, such as Nature, Nature Medicine, Nature Neuroscience, J. Clin.
Invest, and J. Exp. Med. Our basic medical research include the successfully geneticallymodified marmoset monkey that may contribute to the creation of primate models of various
diseases, the discovery of a natural helper cell playing an important role at the time of allergy andparasite infection, the report of an evaluation of the diversity in the safety in iPS cell strain thatis said to hold the key to stem cell medicine, and the elucidation of the system in which
Langerhans cells, which are involved in an immune response of the skin, gain external
antigens. In addition, researches toward clinical application may include the confirmation that thetransplantation of human ES/iPS cells-derived neuronal progenitors can enhance the recovery of
the function from spinal cord damage at the thoracic level, and the discovery of a method ofconcentrating myocardial cells generated from ES cells or iPS cells at a high level of purity. And
as an actual clinical application, we successfully transplanted a cultured corneal epithelium sheet

into patients with corneal damage.
With regard to education, we have held the GCOE Stem-cell Seminar 17 times and theinternational symposium twice as was originally scheduled, where we invited internationallyacclaimed scientists from overseas. The opportunities to witness the trends in international
research while on the campus of Keio University School of Medicine were greatly valued by theparticipants as productive initiatives. In addition, we have continuously establishedcollaborative interactions with the University of California, Irvine, the University of Texas MD
Anderson Cancer Center, and the Lund University Stem Cell Center, who are the leaders inregenerative medicine research and cancer stem cell research. We believe that there arealmost no other institutions that have such rewarding environments for education andresearch among research programs specializing in stem cell medicine research in the world. Afterthe third year, we will strive to maintain and improve on our efforts to be the world leader bothin terms of research and education.
Main Events Held in FY2009
Summer School Keio-Lund 2009 (August 3-4, 2009)
Education and Research Center for Stem-Cell Medicine (February 25-26, 2010)

Young scientists giving a poster presentation at the
symposium (Feb.25-26, 2010)

Summer School KEIO-LUND 2009 (Aug.3-4, 2009)30

Global COE Program [Mechanical, Civil, Architectural and Other Fields of Engineering] FY2008

Center for Education and Research of Symbiotic, Safe and Secure System Design
Program Leader: Takashi Maeno (Professor, Graduate School of System Design and Management)
http://www.gcoe-s4design.keio.ac.jp/en/index.html
This center was established for the purpose of establishing the methodology of designingsystems that explicitly take into consideration social values, such as symbiosis and safety,
conducting specific research into symbiotic and safety system design, and nurturing the humanresources who understand them. The center has concluded the second year since it wasestablished. In FY2009, we placed importance on establishing a platform for the methodology ofsymbiotic and safety system design and the methodology of education, as well as advancing
specific research into system design, in close cooperation with the parent organizations,
namely, the Graduate School of Science and Technology and the Graduate School of System Designand Management.
First, our activities concerning the methodology of symbiotic and safety system design and themethodology of education yielded results in educational engineering research related to thecreation of the Graduate School of System Design Management, which was started
simultaneously with this center and which has many concepts that overlap those at thiscenter. These results are among those of the 21st century COE program. The research is the resultof the practical cooperation and collaboration of members at the center, including members at
international collaborative facilities (MIT, Stanford University). It is an innovative result in the areaof educational engineering, which demonstrates the innovative qualities of the center per se. One
of its core courses is the design project, ALPS (Active Learning Project Sequence).
The specific research into system design yielded many international research results that are

mutually related as a system. First, in the area of energy and resources, we obtained results fromresearch into cluster-type energy management system, research into fuel reforming devices
that supply hydrogen to fuel batteries, the core of distributed energy systems, research intomodeling and crystalline growth of clathrate hydrate system, research into life architecture,research into the methods of assessing the influences of the effects on health of indoor
environmental pollution on the life cycle, research into integrated safety management
systems, etc. In the area of mobility, we obtained results from research into control technology for
active suspension, taking into consideration the safety and ride quality, research into
intellectual flight control technology taking fault-tolerance into consideration, research into
technologies for engine development support/craft design support for hypersonic aircraft,
research into safe intellectual control technology for mobile robots, etc. In the area of humanmechanical systems, we obtained results from research into the touch perception of humans,
research into the cognition of intentions and gestures of robots and humans, research into themodeling of sensor networks, research into immersive driving simulators, research into built-in realtime systems of robots, research into human safety, etc.
In addition, we presented the above results at many symposiums and other events indicated below,
engaged in active discussions with experts inside and outside Japan, and also achieved
international recognition.

Design Project comprising international collaborative Lecture and poster sessions at the international symposium on symbiotic and safety system design
lectures: ALPS (Active Learning Project Sequence)(Feb. 26, 2010)

International symposium on clathrate hydrate(Mar. 15, 2010)

Global COE Program [Social Sciences] FY2008

Raising Market Quality – Integrated Design of "Market Infrastructure"
Program Leader: Naoyuki Yoshino (Professor, Graduate School of Economics)
http://www.coe-econbus.keio.ac.jp/

Raising Market Quality
This program sets four core themes: (1) complexity system analysis of the dynamics of market
quality, (2) creation and demonstration of panel data to verify the dynamics of the Japanese labormarket, (3) verification of the theory of market quality from various viewpoints, such as applied
economics, history, and enterprise system, and (4) presentation and actual introduction of a newpolicy ideas that replace market fundamentalism, called raising market quality.
Global COE, Education and Research
We are aiming to establish an attractive education system, to advance research at this center for
the future, and to nurture many young economists who will become the leaders in raisingmarket quality. Through these educational research activities, the objective of this center is tocontribute to the establishment of the world economy with high-quality markets and tocontribute to economic recovery after the financial crisis. We are drawing up the center's own
unique plans for (1) managing the center's own unique education curricula, (2) arranging the
research environments for many graduate students and young scholars, (3) providing financial
support, (4) providing opportunities for the people in charge of education at the university to learn
the necessary skills by giving reports at seminars, domestic academic conferences,international academic conferences, etc., and (5) expanding the opportunities for researchers to
obtain employment and further their careers by approaching government agencies andcompanies. To create an open university, we reformed the system for graduate education, and we
introduced a system for supporting overseas students and a scholarship system. In our
research, we have continued with existing plans for activities such as domestic academic
conferences and symposiums, and have also sponsored international conferences and held
sessions in overseas academic conferences, in cooperation with the members of Kyoto
University and with the involvement of graduate students.
Panel Data Analysis and Economic Policies
The "Joint Research Center for Panel Studies" was certified as a center for joint use/joint
research by MEXT in FY2008, centered around the Panel Data Research Center at Keio
University. The center at Keio University was established with funds for the formation of a
research center for the 21st century COE program, Development of a Theory of Market Quality andan Empirical Analysis Using Panel Data. Researchers are progressing with thedesign/construction and investigative research for panel data in collaboration with this center. The

31

concept of market-based public-works projects advocated by this center has been having agreat impact on international organizations and economic policies in many countries.
Theoretical Research
In theoretical research, we established the interface between theory and demonstration,
focused on the complex system analysis of the dynamics of market quality, and obtained basic
research results concerning the elucidation of the complex system dynamics between theindustrial revolution and market quality. The biggest goal of collaboration with the Institute of
Economic Research, Kyoto University, is to provide an attractive educational environment by making
good use of its international network. Another major emphasis in the initial plan is to elucidate thedynamics of market quality with complex system models in collaboration with the members of
Kyoto University, who are leading complex system scientists. The collaboration has yielded a
breakthrough in the complex system analysis of market quality and disseminated theimportance of the concept of market quality among complex system scientists, thereby
creating a path to future joint research.
Dynamism of the Market
At the time of applying for the GCOE program, we pointed out the possibility of an economic crisis
occurring due to a reduction in the quality of corporate financial markets. We also pointed out theefficacy of complex analysis in the dynamics of market quality. This prediction became a
reality when the financial crisis occurred in September 2008. It was also an opportunity for us tobecome more acutely aware of the urgent need for complex system analysis of market quality in
our research into the economic crisis.

Global COE Program follow-up session

Global COE Program [Social Sciences] FY2008

Center of Governance for Civil Society (Designing Governance for Civil Society)
Program Leader: Yoshihisa Hagiwara (Professor, Graduate School of Law)
http://www.cgcs.keio.ac.jp/
The Center of Governance for Civil Society conducts world-class education and research on
governance for civil society, not only in Japan, but in collaboration with partners in the UnitedStates, Asia, and other countries. The CGCS educates and trains young researchers to enable them
to become active internationally. To achieve this objective, the CGCS conducted the following
research activities in FY2009.
Attitude Survey on Governance for Civil Society
To analyze the factors that form and transform attitudes toward governance in civil society, thecenter conducted a panel attitude survey of members of the Japanese public. AIso, to analyze theattitudes of people in local governments where local referendums have been held, the center
conducted a mail-in survey. In addition, the center collected the election pledges of candidates inthe Lower House general election, Upper House regular election, prefectural assembly
election, and assembly elections of government ordinance-designated cities. We analyzed andcoded the results. The center also conducted attitude surveys for all prefectural assembly
members and assembly members of government ordinance-designated cities, and stored thesurveys in the data archive.
The center created a new system that can semi-automatically collect and search for theminutes of meetings of the Lower House, Upper house, and prefectural assemblies.
International Educational Research Activities
The center conducted joint research on governance in civil society with overseas collaborative
institutions (the University of California, Berkeley in the United States, Inha University andYonsei University in South Korea). At the same time, the center expanded partnerships starting
collaboration with Seoul National University and Dongseo University in South Korea, andNational Chengchi University in Taiwan. Specifically, we sent researchers on internships from thiscenter, and accepted researchers from collaborative institutions to promote international
academic exchanges, and also held international conferences. We also sponsored theInternational Symposium on Designing Governance in a Civil Society in November 2009 and March2010 as an opportunity for young scientists to give presentations.
To establish an international research network, this center has been working to promote theinternational joint research project, East Asian Perspectives on Political Legitimacy. This
international research project mainly focuses on political theories in East Asia and promotes
discussions into the question, "what is the nature of good politics?" This topic is analyzed in thelight of globalization, from the viewpoint of various intellectual traditions. Researchers inNorth America and various regions in East Asia are planning a total of six workshops from2010 to 2012. This center is the contact for the project in Japan, and is preparing to sponsor aworkshop titled "Citizenship and Governance" in 2011. The center will also set up
postgraduate student sessions at each workshop, to promote active discussions andexchanges among young researchers.
Publications of Research Results
To become a hub of international discussions concerning governance for civil society, this year thecenter published two issues of the Journal of Political Science and Sociology, a refereed
journal with articles written mainly in English. Also, English collections compiling the research
results of this center, such as Yoshihisa Hagiwara (ed.), Democracy and Governance for Civil
Society and Yuko Kasuya and Nathan Gilbert Quimpo (eds.), The Politics of Change in thePhilippines, were published in FY2009.

A scene of the International Joint Symposium,"Designing Governance for Civil Society"

Special Coordination Fund for the Promotion of Science and Technology [Developing Models for Supporting Woman Researchers] FY2008

Project for Developing Social Capital and a Good Working Environment for Women Researchers*The university president has overall authority over this project.
Project Leader: Kikuko Ota(Director of Work-Life Balance Research Center and Professor of Faculty of Nursing and Medical Care)
http://www.wlb.keio.ac.jp/

The "Project for Developing Social Capital and a Good Working Environment for Women
Researchers" refers to a series of support measures that aim at, conceptualize, plan, andimplement a campus environment infrastructure that enables women researchers to have a
way to reconcile research with life events such as childbirth and child-rearing, while
continuing their careers as researchers. In this Project, we are striving to create a new
movement through mutual cooperation among the university, graduates, and the community by
utilizing and expanding the "Social Capital," a network of people that has been developed
centering on Keio University. Centered on the Work-Life Balance Research Center, the Project has
implemented support measures in the following four categories.
1. Development of Promotion Organization
The center is supporting the establishment of a university-wide system for gender equality incollaboration with the Office for Promotion of Gender Equality, established in March 2009.
With regard to facilities, we have asked for baby chairs and diaper-changing tables to beprovided in the handicapped stall at each campus. These facilities were set up in at least two
locations at each of the campuses in FY2009.
Concerning the provision of a communications environment, we are continuously organizing
the Web conference system so that women researchers can easily engage in communication or
participate in conferences. We are also operating a community website at which information canbe exchanged on the Internet.
2. Childcare Support
To provide a good balance for researchers during their child-rearing period, the center isoperating a temporary childcare support project as a trial by cultivating and making use ofchildcare supporters consisting of students. We renovated part of the center office at the
Shonan Fujisawa Campus to create a space for childcare. Since April 2010, the center has
started a project providing care for children of personnel at the school. Students who havecompleted the training course (consisting of lectures and practical childcare work) are engaged inthis service under the supervision of a nursery teacher.
Since FY2008, we have been continuously involved in the Research Support Program to employ
research support personnel and non-institutional/visiting Childcare Support for Sick Children,
leading to achievements from research into the people receiving support.

3. Empowerment Support
To understand the needs that differ among campuses and specialty areas, we are holding
events for exchanges at each campus, and are supporting information exchanges among
researchers. And we are striving to cultivate the next generation of people providing support
through the presentation of interviews with women researchers as role models on thewebsite, and lecture meetings at affiliated schools, and annual symposiums.
4. Promotion of Investigation and Research
We are continuously surveying work-life balance and promoting gender equality. In FY2009, we
conducted a survey at each campus to segment the needs for and the actual circumstances
surrounding support in researchers based on the results of the survey conducted in FY2008. The
results of the survey are available on the website and elsewhere.

A scene of a panel discussion at the symposium, "Striving for gender equality at Keio University"(Dec. 12, 2009)32

Special Coordination Fund for the Promotion of Science and Technology [Improvement of Research Environment for Young Researchers] FY2008

Career Development Program for Young Investigators in "Cell and Metabolism Research" (Keio-Kanrinmaru Project)
Project Leader: Toshio Suda (Professor, School of Medicine)
http://www.careerpath-prj.keio.ac.jp/kanrinmaru/english/
This project is funded by MEXT. Its aim is to introduce a tenure track program into Keio
University by fostering the next generation of leaders in the basic research of cells andmetabolism. A tenure track program refers to a system in which a young researcher gains
experience as an independent researcher during fixed-term employment and achieves a more stablecareer in research through a rigorous screening. The project aims to establish a system toproduce superior independent researchers, making a major contribution to the world, by
providing various kinds of support to young researchers selected through open international
recruitment, thereby leading to independent, tenured positions both in name and reality. Threeassociate professors (non-tenured) and ten assistant professors (non-tenured), who were
employed in the first fiscal year of the project, have received support that includes research spaceand labor costs for research support personnel, in addition to start-up funds and researchexpenses for each fiscal year. These researchers have been working hard at their research
activities while receiving support in the form of labor and facilities from advisor teachers andrelated existing laboratories.
The university president has overall authority over this project, which is managed by a tenure tracksteering committee as a university-wide organization covering all schools, comprising teaching staff
from related faculties situated in the KARC Career Development Center.
Report on Activities in FY2009
Keio-Kanrinmaru Project Kick-Off Meeting (April)
Tenure track researchers gathered at the meeting, and presented the case for their own
research themes, methods, and target results to people inside and outside the university.
Yoshiko Takahashi, Professor, Graduate School of Biological Sciences, Nara Institute of
Science and Technology, was invited as an external advisor, and everybody present engaged in
worthwhile discussions.

*The university president has overall authority over this project.

At the symposiums, tenure track researchers gave presentations relating totheir research as part of an interim evaluation. A lot of advice wasoffered from people invited as external evaluation committee members. These people included
Professor Olle Lindvall and Professor Stefan Karlsson at the Stem Cell Center, Lund University,
Sweden. The academic standard of this project was very highly regarded.
One tenure track researcher gained a tenure post outside the university (November)
Itsuki Ajioka, Assistant Professor, became an independent associate professor at the Center for
Brain Integration Research, Tokyo Medical and Dental University, becoming the first tenure
researcher from the Kanrinmaru project.
This post is a relatively new type of tenure post in the form of a "rolling" tenure, where thepersonnel are evaluated at intervals of several years. From this achievement, the formal Ajioka
Laboratory was created.
One new tenure track researcher (assistant professor) was employed
In FY2009, the second international recruitment was conducted, and Ms. Kyoko Shirakabe wasselected after a rigorous screening. She is the first female researcher from the Kanrinmaru
project. Under the theme, "Proteomic Approach to the Physiological Roles and Regulatory
Mechanisms of Shedding," she started her research activities in the Shinanomachi Campus in May
2010. This project provided her with start-up funds.

Two international symposiums were held
•August: "Summer School Keio-Lund 2009"(Co-sponsored with the GCOE program, "Education and Research Center for Stem Cell
Medicine")•October: "Keio-Kanrinmaru Project Autumn Symposium 2009"(Co-sponsored with the JSPS Core-to-Core Program, "Stem Cells and Cancer Stem Cells")
Members of the Keio-Kanrinmaru Project

Kyoko Shirakabe,
Research Associate

Special Coordination Fund for the Promotion of Science and Technology [Encouraging Innovative and Creative Young Researchers] FY2008

Medical Biologist Support (MEBIOS) Training Program
Project Leader: Koichi Matsuo (Professor, School of Medicine)
http://www.keio-mebios.com/index.html
MEBIOS (Medical Biologist Support)
This Program aims to cultivate young PhD students imbued with a high spirit of independence whoare able to be active in society beyond their specialty areas, while having a high level ofknowledge related to industrial techniques in the areas of science and engineering,
information sciences, pharmaceutical sciences, and so forth centering on medical sciences.
To postdoctoral and Ph.D. students who have qualified for selection within the last five years after
completing their degree, we have provided internships of at least three months by linking up andcollaborating with businesses and research organizations both in Japan and overseas. We
have also provided professional training courses, including open seminars.
At this Program, mentors who have experience as corporate executives are designing flexible anddetailed programs that are suited to individual researchers taking part in the Program. The
Program to date has accumulated various kinds of experience in helping young researchers to makecareer path plans, thereby fulfilling the system as one of the university's initiatives.
Report on Activities in FY2009• Improvements made to the system for operating the MEBIOS Office
The preparation of documents related to the contract and the selection criteria in thescreening examination (assessment sheet for the screening examination); preparation of theprocedure for the MEBIOS Program.
• Selected MEBIOS candidates and MEBIOS members
PhD students that pass selection (selected MEBIOS candidates) are hired by the university for up
to one year, and are able to participate in a program where they gain practical experience.
Even without receiving a screening examination, they can be registered as MEBIOS members andcan participate in career consultations and open seminars. This fiscal year, eighteen
individuals are taking part in the Program, and the number of registered members has
increased to double the number it was last year.
• MEBIOS corporate members
To expand the number of internship placements, we have newly entered into cooperative
contracts with companies that are engaged in food, machinery, shipbuilding, automobiles, and aninternational patent office in addition to the existing partnership with pharmaceutical andbiotec companies. A growing number of member businesses and cooperating businesses
support the aim of this Program, and we are also continuously establishing links with new
businesses to respond to the demands of researchers taking part in the Program.

33*The university president has overall authority over this project.

• Practical program
Internships: Internships for three months to
one year have been provided in places where
R&D is conducted in businesses and otherorganizations in Japan and overseas, as well as places of joint studies at the Shinanomachi
Research Park, Keio University. This fiscal year, internships were provided in a generalpharmaceutical company, a biotech company, a 3D image analysis company, an international patentoffice, two general home electronics companies, a CRO company and elsewhere. Seven
individuals were employed at the companies, with one individual being employed by aninternship company.
Professional coaching: Two new initiatives were held as open seminars this fiscal year:"Gakumon no Susume" in MEBIOS-style, where participants could listen to the life experiences ofpeople who have been active in various areas, and the MOT seminar, Introduction to
Innovation Management. And individual training courses on communications, decision-making,business English, and business Japanese were also conducted.
Mentoring system: Mentors with experience as corporate executives provide regularindividual consultations and suchlike as good advisers for young researchers. They also
provide individual guidance in establishing a career path.
• MEBIOS symposium; meetings to report the results
Under the theme of exploring how to achieve a society in which people holding PhDs are able torealize extensive professional activities without difficulty, the underlying target for thisProgram, discussions were held based on the respective standpoints of businesses, theuniversity, and the people holding PhDs. A symposium to consider the current situations
comparatively in relation to overseas (North America) was also held in November.
In February, a meeting to report the results
was held, where presentations anddiscussions were given centering on theexperience of internships of individuals taking
part in the Program. Some companies
cooperating in the internship attended themeeting. Lively discussions were held andvaluable exchanges were made with theparticipating companies.
MOT Seminar (Oct.2009)

JST Core Research for Evolutional Science and Technology (CREST) FY2009

Creation of High-Performance, Ultra-Low-Power, Short-Range Wireless Mobile Information Systems
Representative Researcher: Tadahiro Kuroda (Professor, Faculty of Science and Technology)
http://www.kuroda.elec.keio.ac.jp/
Advances in computers have been supported by the advances in integrated circuits.
Performance and reliability have been substantially enhanced, and costs have also been
reduced by many digits. Things that once existed in computer rooms are now used in personal
computers and mobile phones that we use every day. Downsizing has continued, wearable
computers costing several thousand yen have appeared, and before long, computers
measuring about one cubic centimeter may be embedded for several hundred yen in our living
environments, increasing our quality of life. We will need to supply power to these countlesscomputers, connect them to each other, and connect to the Internet. Wiring them together as
before will no longer be realistic, and wireless connection technology will be required. It will also
be necessary to reduce their power consumption as it may not be possible to connect them to a
power source, and it may be bothersome to frequently charge batteries. In other words,
reducing power consumption for wireless communication with computers and among
computers will be an important issue in the near future. Against this background, the Kuroda
Laboratory and the University of Tokyo started a research project with the support of JST
CREST in 2005. Our goal was to achieve short-range wireless data communication that ishigher by a factor of two digits, while consuming 1/1000 of the energy of conventional
technology.
We have created a number of new circuit technologies and established a design theory for
their maximization. This year, in 2010, we finally realized a reduction in power consumption by afactor of 1000. We achieved data transfer at 1015 bits per second between chips using only several
watts of electric power. We have presented our research results every year at theInternational Solid-State Circuits Conference (ISSCC), an international conference sponsoredby the IEEE. The ISSCC is the world's most widely respected academic conference on

semiconductor circuits. There have been almost no precedents where research papers havebeen published every year at this conference, indicating the high level of interest in and a highregard of this research around the world. In particular, the research paper demonstrating that datatransfer is possible at high speed while using low power with lamination of 128 flash memory chips
attracted much attention from industrial sectors as a symbolic achievement as we move into a newera. We have published a number of research papers at international academic conferences in
addition to the ISSCC. Students at our project were also successful in showing a number of
research achievements. Many of them have strived enthusiastically to be at the forefront of theresearch, published their research results in the international arena, and then launched highachieving careers around the world.
In FY2010, the final fiscal year of the project, we will work energetically to tackle greater
research challenges in the future.
16 chips are laminated in one package.

129 chips are laminated in one package
Flash memory

Flash memory

Controller
CoilController

Conventional SSD

Mounting area: 1/8
Electric power forcommunication: 1/4

ISSCC 2009, ISSCC 2010

Proposed SSD

JST Exploratory Research for Advanced Technology (ERATO) FY2009

JST ERATO Suematsu Gas Biology Project: Innovation for Gas Biology and Medicine
Representative Researcher: Makoto Suematsu (Professor, School of Medicine)
http://www.jst.go.jp/erato/project/sgb_P/sgb_P-j.html
Diverse physiologic actions of gases such as O2, NO, CO, CO2, H2S have attracted greatinterests, while mechanisms for the gas reception and their roles for regulating biologicalsystems as a whole remain largely unknown. Recent metabolome analyses indicate that ratelimiting enzymes of major metabolic pathways with metal-centered prosthetic groups might
sense gases and trigger post-translational modification of macromolecules, suggesting theircrucial roles for stress-responsive adaptation involving management of energy metabolism andtissue repair and remodeling. However, molecular targets involving gas responses and theircontrol reactions in the living body are difficult to analyze using conventional researchtechniques.
The project challenges to dissect these unknown mechanisms by utilizing advanced
technologies as follows;

2. Bioimaging core: Spatio-temporal detection of gas metabolism
We intend to elucidate the spatio-temporal distribution of various low-molecular weightmetabolites in vivo by imaging mass spectrometry and multi-photon microscopy. Furthermore, weare developing a new detection system to visualize gas molecules per se by utilizing a newgeneration of surface-enhanced Raman scattering imaging.
3. Medical application core: Innovation of new medicine to regulate gas metabolism
Using gene-targeting mice & humanized animal platform, we attempt to apply basic findings in Gas
Biology to remedy diseases. We intend to develop a novel diagnostic system and/or gasdelivery system controlling the release of gas molecules for practical use.

1. Nano-biotechnology core: Mining specific gas-responsive receptors andacceptors
We attempt to find out specific gas-responsive receptors and acceptors. To do so, we utilize asuperior affinity nanobeads technology. Furthermore, we intend to utilize metabolome analysis toreveal the gas-responsive targets in various metabolic pathways.

JST Basic Research Programs (PRESTO) FY2009

Creation of Real-World Interactive Media for Artistic Expression
Representative Researcher: Yasuaki Kakehi (Assistant Professor, Faculty of Environment and Information Studies)
http://www.xlab.sfc.keio.ac.jp
This research is intended to create and apply interactive media targeting the spaces in which welive, with the aim of enhancing artistic expression in the area of interactive art. For thispurpose, we have been making an effort to consider intuitive interaction by using thepresentation of appropriate images to combine the real and virtual worlds together and byusing materials in everyday spaces. We have made an effort to produce works using them and tocreate a platform for artists. In FY2009, our specific achievements were: (1) development of adisplay that shows multiple images in actual space, (2) creation of an animation production support
environment by using real objects and hand-painted characters, and (3) production ofmultimodal interactive arts that visualize scents.
Regarding (1), we developed a display system, UlteriorScape, that can present multiple images ona screen placed above a table, which are different from the images on the table. In this way, we
created multi-player participatory applications. In addition to implementing the optical system, weobserved user behavior and listened to the opinions of users through exhibitions.
Regarding (2), we developed Tablescape Animation, a system that enables the intuitive
manipulation of hand-drawn characters by using real objects like manipulating dolls, for the
purpose of supporting spontaneous and intuitive expression of animations. This system

outputs 2.5 dimensional animation based on the movement of actual objects on the tabletop
display. We held some workshops intended for junior members of the public, and verified its effect(Art Advance Mitsukoshi 2009, Workshop Collection 2010).
And for (3), we developed a system for visualizing the flow of scents interactively, utilizing amodality other than visual/auditory sensation. This system can realize a space design andimaging manipulation with scents by using
gas sensors and a projector. The system wasdisplayed at a media art exhibition (Cine Kid
2009: October 14 - 23, 2009, Amsterdam), andearned high praise. We are planning toprogress with our research by repeating thedevelopment of basic technologies and theprovision of places of experience, such as
exhibitions/workshops, to further advance the UlteriorScape (upper left), Tablescape Animation
area of interactive art.
(upper right, lower left), hanahanahana (lower right)

34

MEXT Grant-in-Aid for Scientific Research (S) FY2009

Research into Twins Concerning Sociality and Mental Health - Connecting Genes and Brain Activity
Representative Researcher: Juko Ando (Professor, Faculty of Letters) http://kts.keio.ac.jp/
Mechanisms of the human mind are one of the expressions of the phenomena of life, and in thiscontext, these are subject to genetic influence in a similar manner to every other life activity. The
longitudinal study of twins is intended to identify how these genes are expressed while
relating to the environment during human development. When identical twins, whose genes are
identical, are compared under environmental conditions that are exactly the same as nonidentical twins, who share only half their genes, we find that genetic influences are greater thanenvironmental influences. The study applies this principle to cognitive ability, linguistic ability,
personality, social interaction, mental health, etc. to identify the influences of genes and theenvironment on development continuity and changes during the first few years of life and forseveral years during adolescence.
The manner in which genetic influence occurs changes through interaction with theenvironment. For example, the appearance of problematic behavior in childhood is related to theparents' behavior toward childcare, but it is not necessarily true that the parents' strict or rigid
discipline is liable to result in problematic behavior. In our research, the stricter the behavior toward
childcare, the greater the influence of genes on problematic behavior appears to be and the greater

the apparent difference between individuals with andwithout the predisposition. Specifically, even individuals
who have a predisposition for problematic behavior do noteasily exhibit problematic behavior if they are in an
appropriate childcare environment, and individuals withouta causative factor do not easily exhibit problematic behavior Scene of a survey of twins
conducted in a school setting
even in a strict environment.
Our project is beginning to identify how these genetic and environmental influences on our
mind and behavior are related to brain activity, and which genes are involved. Even between
identical twins whose genes are identical, we sometimes find major differences in behavior, but
this suggests differences in gene expression due to the environments. If the relateddifferences in the brain structure or function and the transcription to RNA and epigenetics(epigenetic/chemical changes in DNA) become known, we may be able to find mechanismsthat bridge genes, the brain, behavior and the environment.

MEXT Grant-in-Aid for Young Scientists (B) FY2009

Research into the Atmospheric Gravity Wave Emitted from the Jet Stream
Representative Researcher: Norihiko Sugimoto (Assistant Professor, Faculty of Law) http://www.sci.keio.ac.jp/member/detail.php?eid=00014&katagaki=3&status=1
Gravity waves that exist in the atmosphere (waves whose restoring force is buoyancy)transport kinetic momentum over long distances, and play an important role in the generalcirculation of the mid-level atmosphere (the stratosphere and mesosphere). The generalcirculation of the mid-level atmosphere has a great impact on climatic changes through thetransport of substances such as ozone and carbon dioxide. For this reason, the processes of
excitation, propagation, and dissipation of gravity waves are important research themes inforecasting future climatic conditions by using climate models (computer-generated models of theconditions on earth). Research based on observation in recent years has revealed the emission ofgravity waves from strong vortex-like flows, such as jet streams and typhoons, but the process bywhich they are emitted is still poorly understood. In this research, we are using an approach thatconsists of both numerical experiment using a simplified model of the earth's atmosphere andtheoretical research based on the theory of vortex sound (the theory of how sound waves are
emitted from a vortex) with the aim of elucidating the process by which it is emitted.
Previous studies have quantitatively evaluated the emitted gravity waves and examined themechanisms by which they are emitted using the shallow water system on an f-plane (anapproximation where the effects of the axial rotation of the earth are regarded as being fixed on
the plane). This is the most simple system that contains the vortex-like flow and gravity
waves, and recently, an expansion of the system spherically (the effects of the axial rotation of theearth involve latitude variation). As a result, it has become clear that the effects of the axial rotationof the earth have a great impact on the emission of gravity waves.
In FY2009, we conducted the following research to build upon the research that has been
conducted to date. Initially, in a more basic framework, we investigated the process by which
gravity waves are emitted from co-rotating vortex pair. In this framework, it is possible toderive the analytical solution for the field of a gravity wave at a remote distance by citing the theoryof vortex sound and using the Green's function. Next, in the same framework, we performed anumerical experiment, and confirmed the consistency between the obtained analytical solution andthe results of numerical calculation. Currently, we are conducting parameter scanning
experiments in which more complex positions of vortices that cannot be derived analytically arechanged and the effects of the axial rotation of the earth or the propagation speed of gravity waves
are changed. We are planning to elucidate the mechanisms by which gravity waves are
emitted from vortex-like flows under more general conditions.
In the current climate models, the emission of gravity waves from vortex-like flows cannot beappropriately reproduced. For this reason, we expect that the results of this research will be actively
utilized so that climate models can provide more reliable forecasts.

State of an atmosphere gravity wave (mid-level) emitted from the jet stream (left) in a simplified
numerical model of the earth's atmosphere

MEXT Grant-in-Aid for Scientific Research (S) FY2009

Nanoscale Helium Physics and its Applications
Representative Researcher: Keiya Shirahama (Professor, Faculty of Science and Technology) http://www.phys.keio.ac.jp/guidance/labs/sirahama/kiban_s/index.html
Superconductivity and superfluidity, which are fundamental phenomena occurring at very low
temperatures are typical examples of "symmetric breaking." These phenomena are expected toform the basis of quantum computers and other devices based on the principle of quantum
coherence. This research is aimed to search for and elucidate new quantum phenomena thatappear when helium atoms, which are Bose particles, are confined in nano-space. In this way, we
hope to cultivate a new concept in condensed matter physics and develop quantum devices, suchas a superfluid Josephson device and a matter-wave interferometer, and to develop it to the stageof practical application. Our aim is to create a new research area that may be called,"Nanoscale Helium Physics."
This research is being promoted in line with four major programs: (1) Elucidation of quantum criticalphenomena in nano-scale helium, which is realized in various nanoporous structures, and thesearch for new quantum phases; (2) Control of the superfluid properties in a nanopore array of
porous alumina, which utilizes the property that superfluidity is strongly suppressed on nano-scales;(3) Development of a superfluid Josephson device, which uses this property; (4) Development ofa matter-wave interferometer, which uses this new Josephson device, and application of the device
to the high-precision measurement of the earth's rotation, etc. and to new research intoquantum interference effects.
These research initiatives are based on the optimum use of experimental techniques at very low
temperatures, which has been cultivated by the Shirahama laboratory at the Department of
Physics, and new nanoporous materials based on porous alumina developed by Honda
laboratory at Yamaguchi University.
In FY2009, the first year of the project, we discovered two types of new quantum criticalphenomena in helium in the nanostructure described in (1). We also started an experiment on thecontrol of superfluidity by using the nanopore array described in (2). These research initiatives have
got off to a promising start. Through the use of nanoscale helium, we investigated thesuperfluidity of solid helium, which has been a recent topic of interest and is actively studied. We
have produced interesting results. We intend to continue our progress in FY2010 and release ourresearch results, while strengthening our exchanges with researchers inside and outside
Japan.
This research is expected to produce typical examples of a strongly correlated Bose particle systemthat exhibits diverse quantum phenomena, and to result in a new concept for condensed
matter physics. In addition, the realization of Josephson device may pave the way to the full-scaleadvancement of nanoscience, which utilizes the phase coherence of helium, and advance a
new area of physics that we may call Nanoscale Helium Physics.

Pressure

Nanopore array of
porous alumina used forsuperfluid control
experiments anddevelopment of theJosephson device

Solid
Critical pressure

Localized
BEC

NormalliquidSuperfluid
Temperature

35

Phase diagram of helium in
nano-porous form

MEXT Grant-in-Aid for Scientific Research (B) FY 2009

A Ubiquitous Active Knowledge Base System Which Realizes Automatic Search, Analysis, and Mechanisms for Providing Video Data
Representative Researcher: Yasushi Kiyoki (Professor, Faculty of Environment and Information Studies) http://www.mdbl.sfc.keio.ac.jp/
Under circumstances where diversification of and changes in social life environments have caused
various disasters and abnormal phenomena, there are demands for the implementation of an automatic
information distribution system for the monitoring and warning of disasters/abnormal phenomena, and forthe providing of subsequent guidance concerning appropriate courses of action. We are directing ourefforts toward the research and development of the Ubiquitous Active Knowledge Base System, whichanalyzes the possibility of disaster or abnormal phenomena occurrence, and automatically distributes thenecessary action plans in response to analysis results.
Our research results from FY2009 produced the following three achievements:
1. We established a model for automatic monitoring and analysis and a warning distribution system thattransmits information in collaboration with three distant locations. It consists of the automatic detection ofdisasters and abnormal phenomena through the use of ubiquitous sensors (HOP process), the automatic
acquisition of the necessary relevant information through an analysis of the data detected, adetermination based on events, and a knowledge base (STEP process). The work also consists of theautomatic detection and the automatic transmission of information at target sites (subjects) that requiremonitoring, and warning information when a disaster or abnormal phenomenon has occurred (JUMP
process). This is known as the "remote Hop-Step-Jump process."
2. Our academic results relating to the creation of this system consist of six journal papers, four invitedlectures at international academic conferences, and 15 presentations at international academic
conferences. One particularly noteworthy result is the winning of the Best Demo Award for system which wecreated and presented at DASFAA2010, a leading international academic conference in the databasefield.

3. We created a mechanism that analyses and automatically distributes information for the purpose of theearly detection of problems. This is done by means of rapid acquisition of information from information
sources, sources which relate to the prevention and detection of damage from disasters and abnormal
phenomena. This mechanism was created as a semantic space and a semantic search mechanism inrelation to the prevention and detection of damage from disasters and abnormal phenomena. Thus what wehave been able to do, is make possible, semantic information distribution along with automatic
situational analysis.
Ubiquitous Active Knowledge Base System

STEP: Semantic Associative Search Engine
Event
Notification

Warning Info.
Notification

Automatic retrieval, analysis, and integration of thenecessary related information

HOP:

JUMP:

Sensor computing
system

Early Warning Notification
SystemAssociative Search and Integration

Sensor control mechanism-1

Spatio-Temporal DB Integration

Semantic Associative Search

Notification to CP

Sensor control mechanism-2

Visualization

Data Analysis / Feature Extraction
Sensor control mechanism-n

Aggregation of
Sensor Data

Knowledge
Base 1

Sound
Notification

Knowledge
Base n

STEP: The system searches, analyzes, and integrates theenvironment data, which is acquired from cameras andsensors on a semantic space. If any disasters or abnormal
phenomena predicted the warning information is
distributed to JUMP.

HOP: A system for monitoring
the occurrence and indicatorsof disasters and abnormal
phenomena by using cameras
and sensor devices.

JUMP: Early warning information is
distributed in real time with graphic
display on client devices of theareas affected by the disaster, as
measured by STEP.

MEXT Grant-in-Aid for Scientific Research (B) FY2009

Development of Bioseparation Systems Utilizing Environmentally Responsive Nanointerface Control Technology
Representative Researcher: Hideko Kanazawa (Professor, Faculty of Pharmacy)

Control of the modification interface ofhigh polymers that are responsive tonano-level environment change[1]. Biomacromolecules 2009,
J. Chromatogr. A (2010)[2]. J. Chromatogr. A (2009)

Conventional method using organic solvents

Reduced Bioactivity

Surfaceanalysisby AFM

Developed
MPLC column

Aqueous
Mobile phase

Dehydration
Hydrophobic
Desorption
ShrinkingHydration
Hydrophillic
Adsorption
Swelling

Heating

Scale up

Down-sizingeof culion le
at mo
ar ro
ep ac
Pr iomB

Research Achievements in FY2009
In FY2009, we published five academic papers, gave twelve presentations at academic conferences, and madeone patent application.
1. Efficient peptide separation utilizing new stationary phase with the use of a high-density
temperature-responsive polymer brushWe modified various kinds of temperature-responsive high polymers (N-isopropylacrylamide) on porous
polymer beads using the surface-inticated atom transfer radical polymerization method, and evaluated themin the temperature-responsive chromatography solid phase. There are expectations for these molecules asa stationary phase for new bio-separation, which replaces silica gel and its associated problem ofdurability [1].
2. Measurement of blood concentration in the anesthetic agent, propofol, using temperatureresponsive chromatography
We applied a method for measuring changes over time in the blood concentration of propofol, an
intravenous anesthetic agent, in monkeys to whom the drug was administered. Only water is used for themobile phase, and the retention time can be controlled by the column temperature. Therefore, neither
patients nor healthcare professionals will be exposed to organic solvents, ensuring safety when used in clinicalpractice [2].

mm

Our group has developed highly functional separation supports based on the idea that hydrophilichydrophobic changes by temperatures on the surface of separation supports using temperatureresponsive high polymers. We created a system that enables separation by temperature control alone. The
temperature-responsive chromatography that we developed is the world's first research as a separation
technique using functional high polymers. The research is highly regarded in the area of analyticalchemistry both inside and outside Japan. For instance, the research was featured on the cover ofAnalytical Chemistry, the academic journal of the American Chemical Society.
The objective of this research is to develop a bio-separation system based on a completely novel
concept, namely, the molecular design of intelligent high polymers that recognize and respond toenvironmental changes. Based on nano-interface control technology for functional polymer-modified
separation supports, the aim of the project is to advance the technology that regulates interactions withproteins by stimulation-responsive high polymers, and to construct a bio-separation system, which is an
important key to the production of biological drugs. The aim of the project is also to realize on-site
analysis of biological functions, in which the monitoring of drugs is performed in real time in clinicalpractice. .

Reductionin the size ofthe system
detector
microchippump

Contribution to healthcare
and drug discoveries

Cooling

Green Bioseparation

ProteinOn-site measurement
Phenotype analysis for individualized drug therapies
Biofunction analysis
Search for bio markers

EnzymeDNA

Health and Labour Sciences Research Grants [Project for research into the control of rare diseases] FY2009

Research for Ossification of the Spine Ligament
Representative Researcher: Yoshiaki Toyama (Professor, School of Medicine) http://mhlw-grants.niph.go.jp/niph/search/NIDD00.do
This research group had the designation of the specified disease in 1975, and Yoshiaki Toyama became theseventh representative researcher in 2008. The aim of the group is to establish a diagnostic andtreatment system for the ossification of spine ligaments through research into the disease. The group is
engaged in searching for disease-related genes/proteins, conducting multi-center clinical studies andformulating guidelines, etc. in cooperation with 37 institutions nationwide.
The main target diseases for this research group are ossification of posterior longitudinal ligament(OPLL), ossification of the ligamentum flavum (OFL), and fibrodysplasia ossificans progressive (FOP).
In FY2009, a survey on the prevalence of OPLL revealed that the incidence was 2.1%, and in the gene
research, the number of sib blood samples reached the target (200 samples). In FY2010, we commenced
linkage analysis using the affected sib-pair method. In addition, we identified new disease-specificproteins, and made a patent application. Our multicenter research consisted of: 1) A prospective survey onneurological symptoms; 2) Formulation of alarm points for intraoperative monitoring to prevent spinal
cord disorders; 3) A survey on the occurrence of leg paralysis in laminoplasty; 4) Investigation into theoutcomes of surgical treatment for thoracic spine OPLL; and 5) A survey on pain and ADL disorder from theviewpoint of patients, thereby producing results that can be provided to benefit people in a clinicalsetting.
On the other hand, fibrodysplasia ossificans progressive (FOP) is a very rare disease, and there are many
unclear aspects concerning even its natural course. In FY2009, we analyzed signals that inhibit ALK2
activity with the aim of elucidating the pathological conditions. We investigated 1,040 types of drugs
approved by the U.S. Food and Drug Administration (FDA) in our quest to find candidate therapeutic

drugs. Clinical research revealed that the mobility may decrease over time from elementary school tojunior high school, thereby necessitating support for ADL. Hallux valgus, which can be a clue to early
diagnosis, was seen in 93% of cases as some kind of deformation, thereby suggesting that it may
become a useful diagnostic tool.
The final goal of this research group is to provide the newly
acquired knowledge so that it is of benefit in actual clinicalpractice. Currently, there are no effective therapies (drugs) to
suppress the progression of ligament ossification, andconsequently, there is a very great demand for a new
therapy amongst patients. Members of patients'
associations have participated in the meetings held to reportresearch results, and the meetings have been an effective The meeting held to report the results ofmeans of providing the latest information and exchanging research
opinions.
We intend to produce results that can be of benefit toclinical practice by progressing with our research in andafter FY2010, based on the results obtained in FY2009.

Opening remarks by Yoshiaki Toyama

36Research Funds at Keio University in FY2009
Research funds at Keio University from national and local public institutions, private businesses, and university funds totaled approximately ¥18.9 billion
in FY2009. The charts below show research fund totals classified in various ways, such as by type of fund, by type of external entity making thecontribution, by campus, by researcher affiliation, and by research field.

1. Research Funds by Type
When classifying by type of research funds,
specified contributions account for the largest
number of projects and subsidies account for thelargest amount in yen. University funds
represent less than 4% of the total at 700
million yen. Research funds from external
entities represent nearly 96% of the total at
18.2 billion yen.
*The total for university funds includes a contribution
from the Current Expense Subsidies for Private
Universities.
•Improvement project for high technology research
center/Science frontier program/Community
collaboration program/Improvement project for open
research center•Creation and support of a base for strategic researchat private universities

Research Funding Share by Type
(Amount (outer ring), Number of Projects (inner ring))
University Funds% Contracts%

Contracts

0.4%

3.9

Joint Research

9.9%

Joint Research
%

8.4

0.2

Subsidies

Specified
Contributions

Subsidies

26.7%

Specified
Contributions

Amount

University Funds

705

739,547

Subsidies

977

8,375,120

GrantsGrants44

118,684

0.6%

Specified Contributions

1,149

2,155,464

Commissioned Research

416

5,881,953

Joint Research

361

1,587,371

670,601

Total

5

2,438

3,663

18,931,178

Specified
Contributions

Technical
Guidance

Commissioned Research:
Research commissioned by government andother public offices, as well as private
enterprises.

GrantsNumber of Projects

Technical GuidanceContracts

Specified Confributions:Contributions earmarked for research activities.

Thousand yen

Contracts

GrantsGrants:Research expenses provided mainly byfoundations for the purpose of improvement or
accomplishment of research.

44.2%
31.4%

Type of Funds

Joint
Research

Subsidies:
Research funds provided mainly by government
and their public offices.

19.2%

11.4

31.1%

Subsidies

Definition

University Funds

Commissioned
Research

Commissioned
Research

Technical Guidance

0.1%
Commissioned
Research%

University
Funds

1.2%

11.4%

Joint Research:
Collaborative research through personnel
exchanges and/or sharing technology/facilities
under the joint research agreement, with orwithout payment of research funds.
Contracts:
Research under a contract agreement.
Technical Guidance:
Research involving technical guidance such as
development of equipment or apparatus.

2. Types of External Entities Contributing Research Funds
This category classifies funds by the type of
external entities making contribution. Private
corporation accounts for the largest numberof projects while the government accounts forthe largest amount in yen.
*This chart represents the total number of projects andamount in yen excluding the "University Funds" item in"1. Research Funds by Type."

Government

Non-profit Foundation,
Charitable Organization

Local Public
EntityForeign Country

Independent
Administrative Agency,
Semi-Governmental
Corporation

Private Individual

PrivateCorporation

Other

Other University

Government

Non-profit Foundation,
Charitable Organization
Foreign Country%
Private Individual%
Other University
Non-profit Foundation,
%
Other
%
Charitable Organization%%
Foreign Country%
Other
Other University
%
%

3.0

Number of Projects

Amount1,007

9,602,949

0.5

0.1

6.0

Thousand yenType of External Entity

Contribution Share by External Entity Type
Amount (outer ring), Number of Projects (inner ring))

0.4

0.2

0.3

0.6

0.5

Local Public Entity

24

834,505

Independent Administrative Agency, Semi-Governmental Corporation

201

2,756,044

PrivateCorporation

Private Corporation

1,426

4,246,376

23.3%

Other University

15

13,621

Non-profit Foundation, Charitable Organization

177

540,278

Foreign Country

10

95,075

Private Individual

81

71,089Other

17

31,694

Total

2,958

18,191,631

PrivateCorporation

48.2%

Government
PrivateIndividual%

Government

34.0% 52.8%

2.7

Independent
Administrative Agency,
Semi-Governmental
Corporation .

15.2%

Local Public
Entity0.8%
Independent
Administrative Agency,
Semi-Governmental
Corporation

6.8%
37

Local Public Entity

4.6%

Commissioned Research Expenses by External Entity Type

Thousand yen

Number of Projects

AmountGovernment

56

2,068,594

Local Public Entity

16

65,364

Independent Administrative Agency, Semi-Governmental Corporation

141

2,459,721

Type of External Entity

Private Corporation

167

1,110,212

Other University

3

7,640

Nonprofit Foundation, Charitable Organization

26

84,680Foreign Country

5

81,750

Other

2

3,992

Total

416

5,881,953

Commissioned Research Expenses by External Entity Type
(Amount (outer ring), Number of Projects (inner ring))
Nonprofit Foundation,
Charitable Organization Foreign Country
Other
Other
University
%
%
%
%

1.4

0.1

1.4

Foreign Country

Private Corporation

Government

6.3

0.7

0.1%

Foreign Country

0.6% Nonprofit
Foundation,

Other
University

2.5%

Charitable
Organization

10.0%

0.5%

Other University
Nonprofit Foundation,
Charitable Organization

Local Public Entity

3.8%

Other

Government

35.2%

40.1%

Independent Administrative Agency,
Semi-Governmental Corporation

33.9%

Local Public Entity
Independent
Administrative Agency,
Semi-Governmental
Corporation
Independent%
Administrative Agency,
Local Public Entity
Semi-Governmental
Corporation%%

Independent Administrative Agency,
Semi-Governmental Corporation

41.8%

Local Public Entity

1.1%

5.9

1.1

7.5

Private Individual
Private Individual

Nonprofit Foundation,
Charitable Organization

0.6%

Joint Research Expenses by External Entity Type
Local Public
Entity4.4%

3.9%

PrivateCorporation

Other

1.2%
13.5%

18.9%

0.3% 0.8%

0.1
Other
University

Independent
Administrative Agency,
Semi-Governmental
Corporation

Foreign Country

Joint Research Expenses by External Entity Type
(Amount (outer ring), Number of Projects (inner ring))
Other

0.1

Nonprofit Foundation,
Other
Charitable Organization
University%%

PrivateCorporation

PrivateIndividual%

Government
Local Public
EntityType of External Entity

Independent
Administrative Agency,
Semi-Governmental
Corporation

Foreign Country

1.1%

Other University

Private Corporation

78.9%

12,000Independent Administrative Agency, Semi-Governmental Corporation

27

93,792

Private Corporation

285

1,306,549

Other University

9

1,500

Nonprofit Foundation,
Charitable Organization

Nonprofit Foundation, Charitable Organization

14

158,423

Foreign Country

Foreign Country

4

9,410

Private Individual

16

1,647

Private Corporation

82.3%

Amount4

Local Public Entity

PrivateCorporation

Thousand yen

Number of Projects

Private Individual

Other

Other

2

4,050

Total

361

1,587,371

3. Research Funds by Campus
At Keio University, each campus has an Office of
Research Administration that manages research funds.
Classifying research funds by campus shows that
Shinanomachi Campus (home of School/Graduate
School of Medicine) accounts for the largest number ofprojects and the largest amount in yen, followed inboth categories by the Yagami Campus (home of theFaculty/Graduate School of Science and Technology).

Research Funding Share by Campus(Amount (outer ring), Number of Projects (inner ring))

Hiyoshi Campus

Shiba-Kyoritsu%

Tsuruoka

1.9

5.3%

Yagami Campus

Shin-Kawasaki

Shin-Kawasaki

1.9%

0.2%

Tsuruoka

Mita

Hiyoshi

0.7%

Shiba-Kyoritsu*The totals are compiled based on the home campus (in principle, theaffiliation of the research project representative). However, theactual research may take place at a different campus.
Thousand yen
CampusNumber of Projects

AmountMita Campus

313

1,966,634

Hiyoshi Campus

246

484,979

Yagami Campus

754

3,500,673

Shinanomachi Campus

1,821

8,869,618

Shonan Fujisawa Campus

428

2,472,300

Shiba-Kyoritsu Campus

70

284,303

Shin-Kawasaki Town Campus

6350,336

Tsuruoka Town Campus
Total

25

1,002,335

3,663

18,931,178

Mita Campus

1.5%

13.1%

Shonan Fujisawa Campus
Shiba-Kyoritsu Campus

10.4%
ShonanFujisawa

Shinanomachi Campus

ShonanFujisawa

2.6%

Mita

Shin-Kawasaki Town Campus
Tsuruoka Town Campus

8.5%

Hiyoshi

6.7%

11.7%
YagamiYagami

18.5%

20.6%
Shinanomachi

49.7%
Shinanomachi

46.9%
38

4. Research Funds by Affiliation of Researchers
Classifying funds by affiliation of researchers (in principle, the research
representative) shows that the School/Graduate School of Medicine accounts
for the largest number of projects and amount in yen, followed by the
Faculty/Graduate School of Science and Technology.
Research Funds by Researcher Affiliation (in order of amount)
Thousand yen
9,000,000

Affiliation of Researcher

Number of Projects

AmountFaculty/Graduate School of Letters

137

714,362

Faculty/Graduate School of Economics

103

470,613

Faculty/Graduate School of Law

62377,256

Faculty/Graduate School of Business and Commerce75

158,225

1,808

8,593,578

Faculty/Graduate School of Science and Technology

772

3,947,940

Faculty of Policy Management

128

379,033

Faculty of Environment and Information Studies

229

2,615,994

Faculty of Nursing and Medical Care36

81,129

Faculty of Pharmacy

70

284,303

Graduate School of Human Relations

2

8,060

Graduate School of Media and Governance54277,059

8,000,000

7,000,000

6,000,000

Graduate School of Health Management

5

4,600

Graduate School of Business Administration

17

19,230Graduate School of System Design and Management35

382,468

Graduate School of Media Design32

225,650

Keio Law School

29

41,170Research Institutes

64

209,481

Others5

141,026

Total

3,663

18,931,178

5,000,000

4,000,000

3,000,000

2,000,000

1,000,000

0

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ar
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School/Graduate School of Medicine

5. Research Funds by Field
Classifying research funds by field shows that medical
science accounts for the largest number of projects
and the largest amount in yen. The field classifications
were derived from the MIC (Ministry of Internal Affairs
and Communications) Survey of Research andDevelopment and research expense surveys by theJapan Association of Private Colleges and Universities.

Research Funding Share by Field(Amount (outer ring), Number of Projects (inner ring))

Social Sciences
Science and Technology

Humanities

Others6.4%

2.9%

Thousand yen
Number of Projects

AmountHumanities

235

834,291

Social Sciences341

1,390,079

Science and Technology

942

5,972,502

Medical Science

1,953

9,050,027

Combined181

1,129,844

Others11554,434

Total

3,663

18,931,178

Medical Science

Humanities

4.4%

Combined
OthersCombined

OthersResearch Field

Humanities

6.0%

0.3%

Combined

4.9%
Medical Science

53.3%
Medical Science

47.8%

Social Sciences

7.3%
Social Sciences

9.3%
Science and Science andTechnology Technology

25.7% 31.5%

Definition
Humanities:
History, Philosophy, Literature, Languages, and otherhumanities.
Social Sciences:
Economics, Sociology, Business and Commerce, Political
Science, Law, and other social sciences.
Science and Technology:
Applied Chemistry, Chemistry, Mechanics andShipbuilding, Engineering, Mathematics, Electrics,
Communications, Physics, and other science andtechnology.
Medical Science:
Medicine, Nursing, Pharmaceutical Science, and other
health and medical sciences.
Combined:
Interdisciplinary fields.

39

6. Research Fund Data Over the
Past 5 Years

Research Funds by Type Over the Past 5 Years
Thousand yen

The table shows that research funding over the past
five years (FY2005 to FY2009) has been increasing.
Looking at research funds by type reveals a sharp
increase in commissioned research projects.

FY2005

Type of Research Funds

FY2006

FY2007

FY2009FY2008

University Funds

798,164

749,592

630,666

781,824739,547

Subsidies

6,436,472

6,387,754

6,317,761

6,910,061

8,375,120

Grants

171,421104,794

134,381

166,903

118,684

Specified Contributions

1,604,521

2,063,242

2,194,895

2,142,860

2,155,464

Commissioned Research

4,296,684

4,438,734

5,424,980

5,762,275

5,881,953

Joint Research

1,163,996

2,073,601

1,742,299

1,466,307

1,587,371

Contracts

88,49959,4031,995

290

70,601

Technical Guidance

6,745

0

1,300

1,702

2,438

14,566,502

15,877,120

16,448,277

17,232,222

18,931,178

Total

University Funds
Subsidies

FY2005

14,566,502

GrantsSpecified Contributions
Commissioned Research

15,877,120

FY2006

Joint ResearchContracts
Technical Guidance

FY2007

16,448,277

FY200817,232,222

FY2009

00
0,0
,00

,00

20

15

10

5,0

,00

00

0,0

0,0

00

0
,00

0

00

18,931,178

Direct Research Expenses, Indirect Research Expenses, andGeneral Administrative Expenses Over the Past 5 Years

Thousand yen

FY2005

FY2006

FY2007

FY2008FY200913,137,388

14,142,780

14,467,728

14,563,048

16,117,929

Indirect Expenses

529,791

781,735

1,305,746

1,873,112

1,997,233

General Administrative Expenses

899,323

952,605

674,803

796,062

816,016

14,566,502

15,877,120

16,448,277

17,232,222

18,931,178

Type of Research Funds

Direct Expenses (Direct Costs)

Total

Direct Expenses (Direct Costs)
Indirect Expenses

14,566,502

FY2005General Administrative Expenses

15,877,120

FY2006

16,448,277

FY2007

17,232,222

FY200818,931,178

00

00

0,0
,00
20

15

,00

0,0

00
0,0
,00
10

5,0

00

,00

0

0

FY200940

Researchers at Keio University in FY2009
This section presents data from FY2009 on researchers involved in research and education at Keio University (Professors, Associate Professors, AssistantProfessors and Instructors), doctoral students and awardees of doctor's degrees, and researchers participating in research projects at Keio University but not affiliatedunder the any of the above conditions.

1. Number of Researchers"Tenured researchers" are those employed under full-time contracts without fixed terms. "Researchers with fixed-period contracts" are either full-time or part time. "Special
research professors" are researchers with fixed-period contracts who are paid from external research funds as a condition of appointment.
"Researchers" in the following data only include researchers in the University (Professors, Associate Professors, Assistant Professors, and Instructors). The term excludes
teachers at affiliated elementary and secondary schools of Keio University. The number of non-tenured researchers (that is, the total number of researchers with fixed-period contracts
and special research professors) accounts for 27% overall, but is a striking 42% at Shonan Fujisawa Campus.
Number of people

CampusTenured Researchers

Researchers with Fixed Period Contract

Special Research Professors

Total Number of Researchers

Mita

00000,379

00000000000031

00000000046

0,456

Hiyoshi

00000,316

00000000000022

00000000009

0,347

Yagami

00000,241

00000000000027

00000000024

0,292

Shinanomachi

00000,445

00000000000050

00000000258

0,753

Shonan Fujisawa

00000,136

00000000000042

00000000 58

0,236

Shiba-Kyoritsu

00000,061

00000000000003

00000000 90

0,064

Total

00001,578

00000000000175

00000000395

2,148

As of 1 May 2009

2. Support for Future Researchers
There are two types of doctor's degrees: course and dissertation doctorates. Course doctorates are conferred upon completion of course work with all other requirements.
Dissertation doctorates are conferred on those who have submitted a dissertation with consent of a committee of a graduate school, and passed the examination by a board of review.
The standard period for completion of a doctoral course is three years, except for the Graduate School of Medicine, which maintains a four year standard.

Number of Doctorates Awarded

Number of Students Registered in Doctoral Courses
Number of people

Course Doctorate
Graduate School of Letters
Graduate School of Economics
Graduate School of Law
Graduate School of Human Relations
Graduate School of Business and Commerce
Graduate School of Medicine
Graduate School of Science and Technology
Graduate School of Business Administration
Graduate School of Media and Governance
Graduate School of Health Management
Graduate School of System Design and Management
Graduate School of Media Design
Graduate School of Pharmaceutical Sciences
Subtotal

Number of people
Graduate school

009
006
015
0 8
002
046
063
000
029
0
3
0
5
176

Graduate School of Letters
Graduate School of Economics
Graduate School of Law
Graduate School of Human Relations
Graduate School of Business and Commerce
Graduate School of Medicine *1
Graduate School of Science and Technology
Graduate School of Business Administration
Graduate School of Media and Governance
Graduate School of Health Management
Graduate School of System Design and Management *2
Graduate School of Media Design*2
Graduate School of Pharmaceutical Sciences*2
Total

Admission Capacity

045
015
030
011
020
068
150
008
050
010
011
010
006
434

Maximum Occupancy

0,135
0,045
0,190
0,033
0,060
0,272
0,450
0,024
0,150
0,130
0,122
0,120
0,118
1,349

Number ofStudents Enrolled

123
53
80
45
36
249
305
14
152
25
43
27
31
1,183

As of 1 May 2009

Dissertation Doctorate
Graduate School of Letters
Graduate School of Economics
Graduate School of Law
Graduate School of Human Relations
Graduate School of Business and Commerce
Graduate School of Medicine
Graduate School of Science and Technology
Graduate School of Business Administration
Graduate School of Media and Governance
Graduate School of Health Management
Graduate School of System Design and Management
Graduate School of Media Design
Graduate School of Pharmaceutical Sciences
Subtotal
Total
As of 31 March 2010

41

005
001
012
0 2
003
057
0 7
000
0 2
0
0
0
0
179
255

*1: For the Graduate School of Medicine, the numbers refer to the students enrolled in the doctoral program.
*2: The Graduate School of System Design and Management, the Graduate School of Media Design, and the Graduate
School of Pharmaceutical Sciences were opened in April 2008.

3. Researchers from Outside Keio
Keio University has long emphasized the creation of an environment conducive for intellectual exchange and synergistic cooperation with researchers bothwithin and outside the institution, with the goal of sharing common or related research subject.
Not only undergraduate faculties/graduate schools but also research institutes of Keio University accept researchers from other research institutions anduniversities.

Number of Researchers Accepted—Breakdown by Job Title and Status
Number of people

Number of Researchers

Job Title/Status of Researchers

Qualifications

Research Associates of Faculty of Science and Technology (Yagami)

0,026

Researchers participating in research without a contract of commissioned research.

Researchers of Keio Leading-edge Laboratory of
Science and Technology (KLL) (Yagami)

0, 44Researchers participating in research under a commissioned research contract.

School of Medicine Researcher (Shinanomachi)

0,276

Researchers employed by research, educational, or medical institutions other than the School of Medicine of Keio
University.

Senior Visiting Researchers, Keio Research Institute at SFC(Shonan Fujisawa)

0,302

Researchers accepted by Keio Research Institute at SFC upon application from an institution not affiliated with Keio
University, or that from the applicant him/herself. Applicants must have a master's degree or qualified as equivalent
having experience and achievements as an independent researcher.

Visiting Researchers, Keio Research Institute at SFC(Shonan Fujisawa)

0,128

Researchers accepted by Keio Research Institute at SFC upon application from an institution not affiliated with Keio
University or from the applicant him/herself. Applicants must have a bachelor's degree or qualified as equivalent
having experience and achievements as an independent researcher.

Research Associate, Faculty of Pharmacy (Shiba-Kyoritsu)

0, 28

Researchers participating in research under a commissioned research contract.

Research Associate, Keio Advanced Research Centers (KARC) (Each base campus for activities) 141
Visiting Professors and Researchers * (See Table A)

0,310

Others (See Table B)

1,481

Total

1,736

1

Persons from outside Keio University pursuing internal projects for KARC.

Table A: Visiting Professors and Researchers

Number of people

Mita/Hiyoshi

YagamiShinanomachi

Shonan Fujisawa

Shiba-Kyoritsu

036

018

015

000

001

060

Visiting Associate Professor

018

010

011

000

000

039

Visiting Assistant Professor

09

003

005

000

000

017

000

007

001

000

000

008

053

045

051

000

003

152

Visiting Junior Research Fellow

017

011

004

001

001

034

Total

133

94

077

001

005

310

Job Title, Status
Visiting Professor

000

Visiting Instructor
Visiting Research Fellow

00

000

Table B: Others

Total Number

Number of people

Research Institute

Number of Researchers at Keio University*

Number of Researchers not Employed by Keio

Total Number

Institute of Cultural and Linguistic Studies (Mita)

026

056

0,082

Institute for Media and Communications Research (Mita)

008

033

0,041

032

048

0,080

Shido Bunko, Institute of Oriental Classics (Mita)

010

002

0,012

International Center (Mita)

054

033

0,187

Teacher Training Center (Mita) 00

043

044

0,087

Fukuzawa Memorial Center for Modern Japanese Studies (Mita)

027

036

0,063

The Keio Institute of East Asian Studies (Mita)

019

034

0,053

Center for Japanese Studies (Mita)

008

040

0,048

Research Center for the Arts and Arts Administration (Mita)

018

013

0,031

Global Security Research Institute (G-SEC) (Mita)

040

038

0,078

Research Institute for Digital Media and Content (DMC) (Mita)0

019

0 6

0,125

Institute of Physical Education (Hiyoshi)

019

043

0,062

Health Center (Hiyoshi)

015

000

0,015

Keio Research Center for Foreign Language Education (Hiyoshi)

056

035

0,091

Sports Medicine Research Center (Hiyoshi)

008

010

0,018

Keio Research Center for the Liberal Arts (Hiyoshi)

228

005

0,233

Research and Education Center for Natural Sciences [Hiyoshi]

43

0 5

48

Total

673

481

1,154

Keio Economic Observatory (Mita)

200000000000

Figures show the totals for FY2009.
Sites included in parentheses indicate location of the institution.
*1 Generic designation used for visiting professor, visiting associate professor, visiting assistant professor, visiting instructor, visiting research fellow and visiting junior research fellow.
(Excludes researchers at Keio listed in Table B).
*2 Researchers at Keio University: the figure indicates total number of researchers including teachers in the affiliated elementary and secondary schools of Keio, in addition to tenured and non-tenured
researchers of undergraduate faculties/graduate schools or research institutes. A researcher affiliated to more than two institutions is counted as one researcher of each.

42Intellectual Property and Technology Transfer
1. Intellectual Property
In FY2009, the IPC took 156 domestic patent applications, 52 PCT applications, and 75 international patent applications. The center also registered 36 domestic patents
and 35 international patents.
Patent Applications
PCT

180

Registered Patents

International

160
140

Domestic
166
157

170

156

106
71

58

60
30
10 11

36

38

26

25

20

75

67
37

13

12

10

32

13

0

17

15
11

6
2

2

2003

2004

5

7

19

17

15

52

45

40

35

25
90

83

80

16

37

International

30
99

100

Domestic

35

122

120

40
20

40

170

169
146

0
2001

2002

2003

2004

2005

2006

2009 Domestic Patent Applications
Applications by Technology Field

2007

2001

2009

2008

2002

Applications by Campus

2005

2006

2007

2008

2009

Total Patent Applications by Inventor

Bio / Medical

45%

Yagami (Faculty of Science and Technology) Campus

157

Professors

170

Information / Communication

23%

Shinanomachi (School of Medicine) Campus

91

Associate Professors

40

Materials / Chemicals

17%

Shonan Fujisawa Campus

18

Assistant Professors

51

Control / Measurement

15%

Hiyoshi Campus

9

Instructors and Researchers

7

Mita Campus

7

Students and others

15

Shiba-Kyoritsu Campus

1

Employee(s)02. Technology Transfer
The IPC technology transfer officer ensures the smooth transfer of technology from university to industry. Technology transfer takes the following three forms:(I) Licensing of Keio University's intellectual property to companies(II) Start up venture companies based on Keio University's intellectual property(III) Creation of joint research companies based on Keio University's intellectual property, and continuation of development activities in that company
In FY2009, the IPC made 25 new licensing agreements with companies. The total income in FY2009 was 41.75 million yen.

Number of New Licensing Agreements

Income-Generating Licenses

70

70

60

60

63

62

50

44

40

41

50

43
37

34

44

45
41

40
31

26

30

57
52

25

30

22

20
20

20

10

10

0

14

0
2001

2002

2003

2004

2005

2006

2007

2008

Licensing Revenues

2009

Million yen

90

2001

2002

2003

2004

2005

2006

2007

2008

2009

IP-Based Ventures (Start ups)
6

80
5

80
70
70

64

5

60

60

4

55
46

50

42

42

3
3

40
2
20

2

2

2

30

1

11

1

1

1

2006

2007

2008

1

10
0

0
2001

2002

2003

2004

2005

2006

2007

2008

2009

2001

2002

2003

2004

2005

2009

The IPC supports the establishment of venture businesses. In FY2009, two companies established based on Keio IP were launched: SIM-Drive, Inc. and Arai MedPhoton
Research Laboratories, Corp. Thus far, a total of 19 companies have been established, with Keio University holding an equity stake in 14 of them.

43

Awards for Research Activities in FY2009

Source: Keio Gijyuku Ho (Keio Biweekly Newsletter) Keio University homepage. Entries arranged by date of award.
Date Awarded(YYYY/MM/DD)

Recipient (s)AwardReason for Award

Awarding Institution

2009/04/06

Mitsuhiro Itaya (Professor, Faculty ofEnvironment and Information Studies)
Kenji Tsuge (Assistant Professor(Non-tenured), Graduate School of Mediaand Governance) and others

Nikkei BP Technology Awards

Development of "Giant Genome Remodeling Technology"

Nikkei Business Publications, Inc.

2009/04/07

Shogo Miyata (Assistant Professor,
Faculty of Science and Technology) andothersJSME Medal for Outstanding Paper

For the Paper Entitled "Influence of Structure and Composition on Dynamic ViscoElastic Property of Cartilaginous Tissue: Criteria for Classification Between
Hyaline Cartilage and Fibrocartilage Based on Mechanical Function"

The Japan Society of MechanicalEngineers

2009/04/07

Yasuhiro Kakinuma (Assistant Professor,
Faculty of Science and Technology)

JSME Young Investigator Award(Research)(2009)

For the Study on "Development of ER Gel and Its Application to Micromachining"

The Japan Society of MechanicalEngineers

2009/04/11

Tomohiro Ichinose (Associate Professor,
Faculty of Environment and Information
Studies)

Encouragement Prize of Thesis

For the Research Paper "Land Use Change and Biodiversity Conservation in the
Agricultural Landscape of Awaji Island, Hyogo Prefecture"

The Association of Rural Planning

2009/04/13

Daisuke Takahashi (Research Associate(Non-tenured), Faculty of Science andTechnology)

CSJ Presentation Award 2009

The Oral Presentation Entitled "Target-Selective Photo-Degradation of HIV-1
Protease by a Fullerene-Sugar Hybrid".

The Chemical Society of Japan

2009/05/06

Makoto Ida (Professor, Law School)

The 2009 Eugen und Ilse Seibold
Prize

Contribution to the Promotion and Mutual Exchanges in Academic Affairs as a
Bridge between Japan and Germany in the Area of Legal Science.

DFG, German Research Foundation

2009/05/16

Hirokazu Kono (Professor, Graduate
School of Business Administration) andothersBest Paper Award, Japan Industrial
Management Association

By the Paper Entitled "Safety Analysis under Uncertainties for Investment
Alternatives over Multiple Periods using the Total-Cost Unit-Cost Domain"(Journal of Japan Industrial Management Association, Vol.58, No.6, 2008)

Japan Industrial Management
Association

2009/05/16

Hitoshi Abe (Research Associate, Facultyof Science and Technology)

SSSJ Young-Researcher LectureAward

For the Presentation of "Fe/Cu (001) Surface Antiferromagnetic Coupling Induced
by NO Adsorption and the Comparison CO Adsorption"

The Surface Science Society of Japan

2009/05/21

Masaaki Minakawa (Professor (Nontenured), Graduate School of Media andGovernance)

59th Society of Automotive
Engineers of Japan Awards,
Excellent Paper Award

Paper Title: The Model Concept for a Simple 3DOF Vehicle Model with
Considerations of the Effect of Body Roll

Society of Automotive Engineers ofJapan

2009/05/21

Nobutoshi Yamazaki (Professor, Faculty of
Science and Technology) and others

59th JSAE Award the Outstanding
Technical Paper Award

For the Paper Entitled "Development of a New Driving Posture for Fatigue
Reduction Focused on Biomechanical Loads"

Society of Automotive Engineers ofJapan

2009/05/23

Mikiko C. Siomi (Associate Professor(Non-tenured), School of Medicine)

The Saruhashi PrizeContribution to Elucidating the Molecular Mechanisms of RNA Silencing, Gene
Silencing Pathways Mediated by Small RNAs

The Association for the Bright Futureof Woman Scientists

2009/05/27

Hisanao Yamashita (Professor, Faculty of
Science and Technology)

IEEJ Outstanding Technical Report
Award"The Ultimate Techniques for Measuring Discharge Phenomena in Dielectric
Liquids and their Applications"

The Institute of Electnical Engineersof Japan

2009/05/29

Akira Mita (Professor, Faculty of Scienceand Technology)

The Prize of AIJ 2009, Research
Theses Division

For the Paper Entitled "Study on Diagnosis of Structural Health and Advance ofStructual Safety Based on Dynamical Models"Architectural Institute of Japan

2009/06/06

Yuiko Fujita (Associate Professor(Non-tenured), Institute for Media andCommunication Research)

Yoshimi Uchikawa Memorial Mass
Communication Sciences Award

For Work Entitled "Cultural Migrants: Young Japanese and Transnational Media"(Shin-Yo-Sha, 2008)

The Japan Society for Studies in
Journalism and Mass Communication

2009/06/12

Yasushi Isobe (Associate Professor,
Faculty of Law)

The 25th MASAYOSHI OHIRA
Memorial Prize

For Work Entitled "Center and Province in Contemporary China : Deconcentration
and Provincial Leaders in Guangdong" (Keio University Press, 2008)

The MASAYOSHI OHIRA Memorial
Foundation

2009/06/13

Atsuhiro Yamada (Associate Professor,
Faculty of Economics)

FY2008 Japan Society of Household
Economics Encouragement Award

Research Achievement "Income Distribution of People of Retirement Age inJapan" (Journal of Income Distribution, 16 (3-4), pp. 31-54, 2007)

The Japan Society of Household
Economics

2009/06/21

Takuro Yoda (Professor, Graduate Schoolof Business Administarion) and others

APDM Best Paper Award

For the Paper Entitled "International Comparison of Flow Experience in Video
Games"

Accociation of Product Development
and Management

2009/06/25

Yukiko Sakai (Associate Manager,
Shinanomachi Media Center)
Keiko Kurata (Professor, Faculty of
Letters) and others

Honorable Mention in Posters by the
Medical Library Association
Research Section

Aknowledgement of the High-quality Research of the Poster presentation at
MLA09. "How they "Change": Health Information Consumers in Japan"

Medical Library Association Research
Section (U.S.)

2009/06/26

Ryo Sudo (Assistant Professor, Faculty of
Science and Technology)

Excellent paper award

For the Presentation of "Hepatocyte-endothelial Cell 3D Co-culture Model
Established in a Microfluidic System"

The Japanese Society for the
Research of Hepatic Cells

2009/07/03

Toru Namerikawa (Associate Professor,
Faculty of Science and Technology) andothersKanazawa University - Komatsu
Industrial Collaboration Award

He developed a control system design method and a simulator based on modern
control theory for press machines and this method was implemented on the real
products.

Komatsu Ltd.

2009/07/12

Miki Seko (Professor, Faculty of
Economics)
Michio Naoi (Assistant Professor (Nontenured), Faculty of Economics) and others

Best Paper Award for 2009 AsRESAREUEA Joint International
Conference

For the Paper Entitled "Residential Mobility Decision in Japan: Identifying theEffects of Housing Equity Constraints and Income Shocks under the Recourse
Loan System"

Asian Real Estate Society, American
Real Estate and Urban Economics
Association

2009/07/29

Tomoyoshi Soga (Professor, Faculty ofEnvirnment and Information Studies)2009 The Prize of the Chairman of
Hatsumei Kyokai (Japan Institute ofInvention and Innovation)

Invention of CE/MS Method" (patent No. 3341765)

Japan Institute of Invention andInnovation (JIII)

2009/08/04

Ryohei Furukawa (Research Associate(Non-tenured), Faculty of Letters)

Furuta Young Investigator Award

According to the Presentation "Molecular Characterization and Expression
Analyses of ApDOCK in Starfish Mesenchyme Cells."

Japanese Association for
Developmental and Comparative
Immunology

2009/09/02

Masaru Tomita (Professor, Faculty ofEnvironment and Information Studies)Award for Distinguished Service tothe Metabolomics SocietyInternational Promotion of the Area of Metabolomics, thereby Contributing to theDevelopment of Society

Metabolomics Society

2009/09/02

Koji Suzuki (Professor, Faculty of Scienceand Technology) and others

Advanced Analytical Technology
Award

Creation of a Formaldehyde Responsive Reagent and its Application to a Sickbuilding Gas Sensor

The Japan Society for Analytical
Chemistry

44Date Awarded(YYYY/MM/DD)

Recipient (s)AwardReason for Award

Awarding Institution

2009/09/17

Yuji Nagasaka (Professor, Faculty of
Science and Technology) and others

Best Paper Award of Society for
Chemical Engineers Japan 2008

For the Paper Entitled "Dynamic Observation of the Behavior of the Surface of
Liquid Films of Polymer-Organic Solvent System by Ripplon Surface Laser-Light
Method"Society for Chemical Engineers
Japan

2009/09/26

Eiji Hosoda (Professor, Faculty of
Economics)

Society for Environmental Economics
and Policy Studies Academic Award(1st)

Book Titled "Resource-recycling Society - System Design and Prospects of
Policy" (Keio University Press Inc. 2008/4)

Society for Envirinmental Economics
and Policy Studies

2009/10/22

Yoshiyasu Takefuji (Professor, Faculty ofEnvironment and Information Studies)

Appreciation Award from Japan
Food Service Association

Contribution to Activities of the Food-service Industry and Japan Food Service
Association for Many Years.

Japan Food Service Association

2009/10/23

Hirokazu Kono (Professor, Graduate Schoolof Business Administration)

Distinguished Service Award, Japan
Institute of Industrial Engineering

For the Outstanding Service as Editor-In-Chief of IE Review for over 10 Years andthe Service as Chief Instructor on Engineering Economy Courses.

The Japan Institute of Industrial
Engineering

2009/10/30

Takehiko Mikami (Professor, Law School)

Honorary Doctor of Laws of Saarland
University (Germany)

Contribution to Academic Exchanges between Japan and Germany, Particularly
Contribution to Academic Exchanges between the Faculty of Law, Saarland
University and the Faculty of Law and the Graduate School of Law, Keio
University. Academic Achievements, etc. in the Area of Civilprocedure law andInsolvency Law.

Saarland University

2009/10/30

Makoto Ida (Professor, Law School)

Honorary Doctor of Laws of Saarland
University (Germany)

Contribution to Academic Exchanges between Japan and Germany, Particularly
Contribution to Academic Exchanges between the Faculty of Law, Saarland
University and the Faculty of Law and the Graduate School of Law, Keio
University. Academic Achievements, etc. in the Area of Criminal Law, Particularly
Comparative Criminal Law.

Saarland University

2009/11/03

Ichiro Innami (Professor, Faculty of Policy
Management)

The 52nd Nikkei Prize for Excellent
Books in Economic Science

Based on Original Data Collection and Analyses, the Researcher Found that Socalled Social (Inappropriately) Hospitalization was Attributable to the Lowdensity Medical and Custodial Care for the Elderly, which is Caused by the
Excess Number of Hospital Beds and the Underemployment of Necessary
Manpower, and Devised a Set of Policy Recommendations to Better the Care for
the Elderly.

Nikkei Inc., Japan Center for
Economic Research

2009/11/03

Hideyuki Okano (Professor, School of
Medicine)

Medal with Purple Ribbon

For His Outstanding Achievements in the Research of Development andRegeneration of the Central Nervous System

Cabinet Office, Government ofJapan

2009/11/03

Daisuke Uemura (Professor, Faculty of
Science and Technology)

Medal with Purple Ribbon

Exploratory Research on Bioactive Natural Products with a Focus on Biological
Phenomena

Cabinet Office, Government ofJapan

2009/11/05

Toshiaki Makabe (Professor, Faculty of
Science and Technology)

The Serbian Academy of Scienceand Arts (Foreign member)

Outstanding Contribution to Low Temperature Plasma Electornics

The Serbian Academy of Scienceand Arts

2009/11/12

Yasuhiro Kakinuma (Assistant Professor,
Faculty of Science and Technology) andothersBest Paper Award

For the Paper Entitled "Basic Study on Nanofabrication of Biodegradable Plastics
using Biochemical Machining"

International Conference of AsianSociety for Precision Engineeringand Nanotechnology (ASPEN2009)2009/11/14

Nobutoshi Yamazaki (Professor, Faculty of
Science and Technology) and others

Biomechanism Best Paper Award

Proposal of a Driving Posture for Fatigue Reduction Based on Many-sided
Evaluations

Society of Biomechanism (SOBIM)
Japan

2009/11/21

Ikuo Takahashi (Professor, Faculty ofBusiness and Commerce)

2009 KAMS/KSMA Fall International
Conference, Best Conference Paper
Award

Published Paper "Satisfaction and Dissatisfaction Management in Japan"

Korean Academy of Marketing
Science, Korean Strategic Marketing
Association

2009/12/10

Hiroyoshi Inoue (Professor, School of
Medicine)

2009 Chikuho Bank Bioventure R&D
Award

To Accomplish the Success of High Quality R&D and the Increases of Sales andthe Surplus Settlement Immediately after Establishment as a University Venture

Chikuho Bank

2009/12/11

Yoshiko Uzawa (Professor, Faculty of
Letters)

25th Joseph Roggendorf Book
Award

Hashimura Togo: Yellowface and the Japanese in American Popular Literature(University of Tokyo Press, 2008)

Department of English Literature,
Sophia University

2009/12/25

Yasuhiro Koike (Professor, Faculty of
Science and Technology)

Selected as "Nice Step Scientist" forHis Distinguished Contribution to the
Science and Technoloogy in 2009

Fundamental Research and Realization of High-speed Plastic Optical Fiber

National Institute of Science andTechnology Policy

2010/02/19

Tohru Yamada (Professor, Faculty of
Science and Technology)

SSOCJ Nissan Chemical Industries
Award for Novel Reaction & Method
2009

Development of Optically Active Cobalt Complex Catalysts for Enantioselective
Synthetic Reactions

The Society of Synthetic Organic
Chemistry, Japan

2010/02/20

Hiromichi Kobayashi (Professor, Faculty of
Law)Award for Distinguished Young
Researcher in Fluid Mechanics, theJapan Society of Fluild Mechanics

Development of the Subgrid-scale Model Based on Turbulence Structures
according to the following papers: (1) "The Subgrid-scale Models Based on
Coherent Structures for Rotating Homogeneous Turbulence and Turbulent
Channel Folw," (2)"Application of a Local SGS Model Based on Coherent
Structures to Complex Geometries," (3)"Large Eddy Simulation ofMagnetohydrodynamic Turbulent Duct Flows"

The Japan Society of Fluid
Mechanics

2010/03/05

Issei Fujishiro (Professor, Faculty of Scienceand Technology) and others

IEEE Pacific Visualization
Symposium 2010 Best Poster Award

For the Poster Entitled "Interpolating 3D Diffusion Tensors through Optimizing
Rotatoinal Transformations of Anisotropic Features"

IEEE Computer Society

2010/03/12

Tojiro Aoyama (Professor, Faculty of
Science and Technology)
Yasuhiro Kakinuma (Assistant Professor,
Faculty of Science and Technology)

Best Paper Award

For the Paper Entitled "Development of Electric Field-addisted Polishing Method
using ER Gel"

The Japan Society for Abrasive
Technology

2010/03/17

Toru Namerikawa (Associate Professor,
Faculty of Science and Technology) andothersAward of 9th Annual Conference onControl Systems

He presented a Paper Entitled "Network-Topology Independent Cooperative
Target-enclosing Behavior by Swarms of Vehicles" in the 9th Annual Conference
on Control Systems and it was selected as the most outstanding paper.

Control Division of the Society of
Instrument and Control Engineers

2010/03/19

Takayuki Tatsumi (Professor, Faculty of
Letters)

IAFA Distinguished Scholoarship
Award

Contribution to Research on Contemporary Literature Centered on the Book Titled"Full Metal Apache: Transactions between Cyberpunk Japan and Avant-Pop
America" (Durham: Duke UP, 2006)

The International Association for the
Fantastic in the Arts

45

Date Awarded(YYYY/MM/DD)

Recipient (s)AwardReason for Award

Awarding Institution

2010/03/23

Seiichiro Katsura (Assistant Professor,
Faculty of Science and Technology)

IEEE AMC2010 Recognition AwardFor Commitment to Proposing and Organizing Attractive Session

General Chair of IEEE AMC2010

2010/03/23

Seiichiro Katsura (Assistant Professor,
Faculty of Science and Technology)

IEEE AMC2010 Recognition AwardFor Contribution as International Steering Committee Member

General Chair of IEEE AMC2010

2010/03/26

Issei Fujishiro (Professor, Faculty of Scienceand Technology) and others

2009 Best CG Paper Award

For the Paper "Applying Manifold on Learning to Plotting Approximate Contour
Trees" published in IEEE Trans. VCG, 15(6), 2009The Society for Art and Science

2010/03/26

Yoshio Ohno (Professor, Faculty of Scienceand Technology)

CG Japan AwardFor Contribution to the Development of Computer Graphics

The Society for Art and Science

Introduction to Research-related Information Databases
Researchers Information Database
K-RIS（Keio Research Information System）

Keio Leading-edge Laboratory of Scienceand Technology (KLL) Yellow Pages

Keio Research Institute at SFC Yellow Pages

You can search for the research achievements and profilesof Keio University researchers.

You can search for research projects being conducted in
the KLL.

You can search for research projects being conducted in the
Keio Research Institute at SFC.

http://www.k-ris.keio.ac.jp/index_en.html

http://www.kll.keio.ac.jp/db/index.html

http://www.kri.sfc.keio.ac.jp/kris-yp/

46

Research-related Facilities and Libraries
Research Space for Rent
Keio University provides research space and incubation facilities for rent as indicated below. Policies and availability differ by campus, so please inquire in advance for vacancies, rental
qualifications, application procedures, application deadlines, etc.
As of June 2010

Facility

OutlineFor Inquiries

Kyoseikan Collaboration Space(See pages 13-14)

Total of 5 rooms in Kyoseikan Building on Hiyoshi Campus
Size: each room: 20.82m2; Total floor area: 104.10m2•Kyousei-Kan Operations Center•Tel. +81-45-564-2500•http://www.kcc.keio.ac.jp (Japanese Only)•E-mail: hy-ksk@adst.keio.ac.jp

Research Space at the KLL(See pages 15-16)

Total of 31 rooms in Sousoukan Building on Yagami Campus
Size: 66.12m2 - 102.49m2 ; Total floor area: 2,245m2
Type A (for chemistry and biology experiments)
Type B (for applied physics experiments)
Type C (for experiments for heavy materials)
Type D (for experiments for light-weight equipments)
Type E (for various types of experiments)•KLL Liaison Office•(c/o Office of Research Administration, Yagami Campus)•Tel. +81-45-566-1794•http://www.kll.keio.ac.jp/ (Japanese Only)•E-mail:staff@kll.keio.ac.jp•KLL Liaison Office•http://www.kll.keio.ac.jp/liaison (Japanese Only)

Shinanomachi Research Park
(See pages 17-18)

37 units in the Institute of Integrated Medical Research Building
Steel frame with a reinforced concrete structure; 2 under ground floors,
9 above ground floors, and one penthouse floor
Total floor area: 24,400m2•Shinanomachi Office of Research Administration•Tel. +81-3-5363-3879•E-mail: ras-shinanomachi@adst.keio.ac.jp

Keio Fujisawa Innovation Village(SFC-IV)(See page 20)

Steel frame structure, 2 floors
Site area: 1,825.3m2
Total floor area: 1,470.0m2
Rental space: 906.4m2
offices: 18; small offices: 3; shared offices: 8
R&D fabrication rooms: 3; office/R&D fabrication rooms: 2
server room: 1•Keio Fujisawa Innovation IM Room
•Tel. +81-466-49-3910•http://www.sfc-iv.jp/11.html•E-mail: incubation@sfc-iv.jp

Shin-Kawasaki Town Campus(See pages 23-24)

4 research buildings
Steel-frame structure, 2 floors
Total floor area: 5,336.11m2•Shin-Kawasaki Town Campus•Shin-Kawasaki Frontier Research and Education Collaborative Square•Tel. +81-44-580-1580•http://www.k2.keio.ac.jp (Japanese Only)•E-mail: k2-tc@adst.keio.ac.jp

Tsuruoka Metabolome Campus(Tsuruoka Leading-Edge Research
Industrial Support Center - not a Keio
facility.)(See page 26)

29 units, Size: 7m (L) x 10m (W) x 2.8m (H)Steel frame structure, 2 floors
Total floor area: approximately 3,700m2•Municipal Policy Promotion Division, Planning Department•Tsuruoka City
Tel. +81-235-25-2111 (ext. 528)
http://www.city.tsuruoka.lg.jp/ (Japanese Only)•E-mail: seisakusuishin@city.tsuruoka.yamagata.jp

Sousoukan Building on Yagami Campus

Keio Fujisawa Innovation Village

Library Collections
Keio University has six campuses: Mita, Hiyoshi, Shinanomachi, Yagami, Shonan Fujisawa, and Shiba-Kyoritsu, each one of them developing leading-edge research and education in various
disciplines, and also high-level medical practice. The Media Centers, centering the library service, branch on each campus to provide intensive support for all these specific activities.
As of March 31, 2010
Book Stocks
Total

Number of
Seats

Collections by Material Type
Domestic Books

Foreign Books

Domestic Journals

Foreign Journals

Non-book Materials(items),Mita Media Center

2,711,876

975,082

1,053,952

250,427

297,658

134,757

1,286

Hiyoshi Media Center

897,305

484,014,230,368

70,48974,34038,094

1,435

Shinanomachi Media Centerr

412,878

73,72451,65392,659188,243

6,599

229

Information and Media Center for Science and Technology

364,853

97,39645,29057,215

160,701

4,251

510

Shonan Fujisawa Media Center

420,321231,294

86,69548,98525,952

27,395

1,080

Information and Media Center for Pharmaceutical Sciences

72,42839,927

5,220

7,630

18,064

1,587

147

4,879,661

1,901,437

1,473,178

527,405

764,958

212,683

4,687

Total

There are also electronic media resources (359 databases, 37,972 electronic journals, and 18,275 electronic books).

Mita Media Center (New University Library)47

Hiyoshi Media Center (Hiyoshi Library)

Shinanomachi Media Center (Kitasato Memorial Medical Library)FY2009 Financial Position
Ended on March 31, 2010

1 Balance Sheet
Million yen

AssetsLiabilities

Fixed assets

325,214

Tangible fixed assets

208,348

Fixed liabilities

062,908

Long-term borrowings

0011,963

Land034,135

School bonds

003,144

Buildings

0100,624

Retirement allowance reserve

027,983

Structures

004,747

Pension reserve019,208

Equipment and supplies for

024,955

Long-term accounts payable

education and research

Current liabilities

610
030,820

Other equipment and supplies

000,587

Short-term borrowings

002,726

Books

040,325

School bonds

001,456

000,032

Accounts payable

010,81200112,944

Advances received

013,112

116,865

Deposits

002,625

Telephone subscription rights

000,072

School trip deposits

Facility use rights

000,185

VehiclesConstruction in progress
Other fixed assets

Deposits

Liabilities total

000,89093,728000,005.22

Profit-making business capital

005,692

Funds

Long-term loans

001,633

Funds

Specified assets

062,841First fund313,781

School bond assets producing interest

004,601

Second fund0015,650

Reserve assets for the third fund041,798

Third fund041,798

Software000,0022

Fourth fund

Current assets

033,239

Cash deposits

018,033

Accounts receivable

013,443

Balance of income and expenditure

Inventories

000,662

Carried forward to next year

Negotiable securities
Assets for school trip deposits

Keio Corporate Administration "Jukukan-kyoku" at Mita Campus

Funds total

009,076
380,305

115,58100
000,89Others000,1,011

Total of liabilities, funds, and balance ofAssets total

358,452

income and expenditure

358,452

Source: Activities and Financial Position of Keio Gijuku: FY2009 BusinessReport

2 Income and Expenditure Statement
Million yen

Expenditure

IncomeImputed income

Personnel

64,959Tuition and other student fees

47,363

Expenses for education and research

60,777

Other fees

2,393

Expenses for general administration

3,886

Donations

6,161

Interest on borrowings

345

Subsidies

16,516

Loss on disposition

4,314

Income from asset management

3,289

Provision for allowance for doubtful accounts

70

Asset sales differential

0

Discretionary reserve-

Income from business

8,550

Total expenditure

134,350

Income from medical services

45,226

Miscellaneous income
Imputed income total

Old library at the Mita Campus

3,319
132,815

Current excess over expenditure

11,354

Brought forward from last year

104,226

Transfer to capital fund

△ 9,819

Carried forward to next year

115,581

Income total

122,996

Imputed income total - Total expenditure△ 1,535

Source: Activities and Financial Position of Keio Gijuku: FY2009 Business Report48

Access Information

Mita Campus

Shinanomachi Campus

2-15-45 Mita, Minato-ku, Tokyo 108-8345
Tel +81-3-5427-1517

35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582
Tel +81-3-3353-1211

8-minute walk from Tamachi St. (JR Yamanote Line or JR Keihin
Tohoku Line);
Approximately 10 minutes by train from Tokyo to Tamachi.
Approximately 20 minutes by train from Ueno to Tamachi.
Approximately 15 minutes by train from Shibuya to Tamachi.
7-minute walk from Mita St. (Asakusa or Mita Line);
Approximately 15 minutes by train from Suidobashi to Mita.
8-minute walk from Akabanebashi St. (Oedo Line)

Hiyoshi Campus

Shonan Fujisawa Campus

4-1-1 Hiyoshi, Kohoku-ku, Yokohama-shi,
Kanagawa 223-8521
Tel +81-45-566-1000

5322 Endo, Fujisawa-shi, Kanagawa 252-0882
Tel +81-466-47-5111

1-minute walk from Hiyoshi St. (Tokyu Toyoko Line or Yokohama
Subway Line, Green Line);
Approximately 25 minutes by train from Shibuya to Hiyoshi (20minutes by express).
Approximately 20 minutes by train from Yokohama to Hiyoshi (15minutes by express).
Approximately 20 minutes by train from Shin-Yokohama to Hiyoshi
via Kikuna.

Approximately 15 minutes by bus from Shonandai St.
(Odakyu Enoshima Line, Sagami Tetsudo Izumino Line, or Yokohama
Subway Line);
Approximately 30 minutes by train from Yokohama to Shonandai.
Approximately 25 minutes by bus from Tsujido St. (JR Tokaido Line);
Approximately 30 minutes by train from Yokohama to Tsujido.

Yagami Campus

Shiba-Kyoritsu Campus

3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi,
Kanagawa 223-8522
Tel +81-45-566-1454

1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512
Tel +81-3-3434-6241

15-minute walk from Hiyoshi St. (Tokyu Toyoko Line or
Yokohama Subway Line, Green Line);
Approximately 25 minutes by train from Shibuya to Hiyoshi(20 minutes by express).
Approximately 20 minutes by train from Yokohama to Hiyoshi(15 minutes by express).
Approximately 20 minutes by train from Shin-Yokohama to
Hiyoshi via Kikuna.
Approximately 10 minutes by car from Shin-Kawasaki St.
(JR Yokosuka Line);
Approximately 20 minutes by train from Tokyo to Shin-Kawasaki
Approximately 12 minutes by train from Shinagawa to Shin-Kawasaki.
Approximately 10 minutes by train from Yokohama to Shin-Kawasaki.

49

1-minute walk from Shinanomachi St. (JR Sobu Line);
Approximately 6 minutes by train from Shinjuku to Shinanomachi.
Approximately 15 minutes by train from Tokyo to Shinanomachi.
5-minute walk from Kokuritsu-kyogijo St. (Oedo Line)

10-minute walk from Hamamatsu-cho St.
(JR Yamanote Line or Keihin-Tohoku Line)
Approximately 7 minutes by train Tokyo to Hamamatsu-cho
Approximately 13 minutes by train from Ueno to Hamamatsu-cho
Approximately 18 minutes by train from Shibuya to Hamamatsu-cho
2-minute walk from Onarimon St. (Mita Line)
Approximately 5 minutes from Ote-machi to Onarimon
6-minute walk from Daimon St. (Asakusa Line or Oedo Line)
Approximately 16 minutes from Shinjuku to Daimon
Approximately 7 minutes from Nihonbashi to Daimon

Contact Information
Shin-Kawasaki Town Campus

Shonai Airport

7-1 Shin-Kawasaki, Saiwai-ku, Kawasaki-shi, Kanagawa
212-0032
TEL+81-44-580-1580

Bio-Lab, Institute forAdvanced Biosciences (IAB),
Keio University

ata
Sak

Mita Campus
Head Office of Research Administration
ora-honbu@adst.keio.ac.jp
Mita Office of Research Administration
mshien-ft@adst.keio.ac.jp
CRP: Center for Research Promotion
crp@info.keio.ac.jp
IPC: Intellectual Property Center
toiawasesaki-ipc@adst.keio.ac.jp
KARC: Keio Advanced Research Centerskarc-jimu@adst.keio.ac.jp

N

R7

a
gat
Nii

10-minute walk from Shin-Kawasaki St. (JR Yokosuka Line);
Approximately 20 minutes by train from Tokyo to Shin-Kawasaki.
Approximately 12 minutes by train from Shinagawa to ShinKawasaki.
Approximately 9 minutes by train from Yokohama to Shin-Kawasaki.
15-minute walk from Kashimada St. (JR Nambu Line);
Approximately 7 minutes by train from Kawasaki to Kashimada.

Tsuruoka
ChuoHigh School

JR Tsuruoka St.
Tsuruoka Metabolome Campus

Yamagata University Faculty of Agriculture
Tsuruoka Minami Tsuruoka Kita
High School
High School
Tsuruoka TechnicalHigh School
Chido
MuseumOhyamaCity Library
Police Box

Hie
ShrineHiyoshi Campus
Hiyoshi Office of Research Administration
ras-hiyoshi@adst.keio.ac.jp

Tsuruoka Park

Daitokuji
TempleTsuruoka
City Hall
Chidokan

Yagami Campus
Office of Research Administration, Yagami Campus
yg-shien@adst.keio.ac.jp
Secretariat of Keio Leading-edge Laboratory of
Science and Technology (KLL)
staff@kll.keio.ac.jp

a/A
kita

Cultural
Hall

Sa

kat

Tsuruoka Town Campus
Campus Center, Institute forAdvanced Biosciences (IAB),
Keio University

HaguroR112

Chido Library
Graduate School, Tohoku University of Community
Service and Science
Restaurant
Guest House

Yamagata

Shinanomachi Campus
Shinanomachi Office of Research Administration
ras-shinanomachi@adst.keio.ac.jp

Tsuruoka Town Campus
Campus Center
14-1 Baba-cho, Tsuruoka-shi, Yamagata 997-0035
TEL +81-235-29-0800

Shonan Fujisawa Campus
Shonan Fujisawa Office of Research Administration
info-kri@sfc.keio.ac.jp
Air
Train

Shiba-Kyoritsu Campus
skc-shien@adst.keio.ac.jp

Tsuruoka
Shonai Airport

Shin-Kawasaki Town Campus
k2-tc@adst.keio.ac.jp

Sendai

NiigataTsuruoka Town Campus
office@ttck.keio.ac.jp

Bio-lab403-1 Nipponkoku, Daihouji, Tsuruoka-shi,
Yamagata 997-0017
TEL +81-235-29-0534

Tokyo
Haneda Airport

Osaka

Keio University
Shonan Fujisawa Campus

By air: approximately 50 minutes from Tokyo Haneda Airport
to Shonai Airport, approximately 25 and 18 minutes by carfrom Shonai Airport to Campus Center and Bio-lab,respectively.
By train: approximately 120 minutes by Joetsu Shinkansen(bullet train) from Tokyo St. to Niigata St., then approximately
120 minutes by Uetsu Honsen (main line) from Niigata St. to
Tsuruoka St., then 10 minutes by car

JR Yamanote Line

JR local lines
Ikebukuro

JR Shinkansen
Private railways

JR KeihinTohoku Line

SubwayFukutoshin LineBus
Oedo Line

Namboku Line
Shinjuku

Nagatsuta

Sagami-Ono

JR Nambu Line

HiyoshiCampus

MachidaAzaminoChuo-Rinkan
JR Yokohama Line

Shin-Yokohama

Shinanomachi

Odakyu Line

Yokohama
SubwayBlue Line

Futamatagawa

Shonan Fujisawa
Campus

Sotetsu
IzuminoLine

Shonandai

Akihabara

Namboku Line

Shibuya

HiyoshiDen-en-chofu
Musashi-Kosugi

Tokyu
Toyoko Line

Mita Line

Jiyugaoka

Ebisu

Tokyu Meguro Line

JR Yokosuka Line

Shin-Kawasaki

Tokyo

HibiyaNakameguro
Azabu-Juban

JR Tokaido Shinkansen

Kikuna Shin-Kawasaki

Ochanomizu

Suidobashi

Yokohama Subway
Green Line

Town Campus

JR Tokaido Shinkansen

JR Sobu Line
Iidabashi

Kokuritsukyogijyo

Futako-tamagawa

YamatoOdakyu Enoshima Line

Yotsuya

YoyogiTokyu
Denentoshi Line

Nakayama

Sotetsu Line

Shinanomachi
Campus

JR Chuo Line

YagamiCampusAsakusa Line

Mita
CampusMeguroGotandaHibiya Line

Shiba-Kyoritsu Campus

OnarimonAkabanebashi

DaimonMita

Shimbashi

Oedo Line

Kashimada
Hamamatsu-cho
Yokohama

Kawasaki

JR Tokaido Line

Oimachi

ShinagawaTamachiKeikyu-Kamata
Totsuka
TsujidoKeihinkyuko LineFujisawa
Haneda Airport

Tokyo Monorail50

150th Anniversary in 2008

Keio University
Annual Report on Research Activities
2009–2010
15 November 2010
Published by the Head Office of Research
Administration
2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan
TEL: +81-3-5427-1023
http://www.keio.ac.jp/index-en.html©Keio University 2010

201011.5000.B