Location map of the Institute of Tropical Medicine,
Nagasaki University in Nagasaki City

INSTITUTE OF TROPICAL MEDICINENAGASAKI UNIVERSITY

Mt. Inasa

Ｎ

Ropeway

Nagasaki Bay

Urakami

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og

ak

for Akasako−
OhashiuraHamaguchi-machi
Urakamieki-mae
Nagasaki−
Ohato

Igakubu-mae

Nagasakieki-mae

School of
Dentistry
University
Hospital

School ofMedicine

Urakami−tenshudo-mae

Isibashi
Tsukimachi

Prefectural OfficeInstitute of Tropical
Medicine

City Hall−−
Chuobashi−−
Kokaido-mae
Suwajinja-mae−
Shokakuji-shita

JR Kyushu
Streetcar
Main bus routfor Mogi

for Hotarujaya

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熱研案内パンフ（欧文）表紙４−１! CMYK 芦塚 山道 芦塚 中村

JULY

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Published on July３
０，
２
０
０
５
Edited by Institute of Tropical Medicine, Nagasaki University
Printed by Showado Printing Co.,１００７‐２ Nagano machi, Isahaya８
５
４
‐
０
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６，Japan

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How to get the Institute
１．From Nagasaki Station （JR Kyushu）!Get on a bus (Nagasaki Bus, Line ８）at Nagasakieki-mae and get off at Igakubu-mae.
Five minutes walk from the bus stop.
"Get on a streetcar at Nagasakieki-mae（for Akasako, Line １or３）, and get off at
Hamaguchi-machi. Ten minutes walk from the streetcar stop.
#Ten minutes by taxi from the station.
２．From Urakami Station（JR Kyushu）!Twenty minutes walk.
"Five minutes taxi.
３．From Nagasaki Airport!Get on limousine at the airport（for Nagasaki）, and get off at Nagasaki-ekimae, andthen continue to１．
"Get on limousine at the airport（for Nagasaki）, and get off at Ohashi, and then twenty
minutes walk from the bus stop or ５ minutes by taxi.
#About one hour by taxi from the airport.
Location
１‐
１
２‐４ Sakamoto Nagasaki ８５２‐
８５２３
URL http://www.tm.nagasaki-u.ac.jp

ERS!背は２mm（決）

MISSION STATEMENT
Institute of Tropical Medicine, Nagasaki University

The tropics, the most ecologically diverse region on the Earth, presents an ongoing complexity of tropical diseases and other health problems. In view of the remarkable advances made in
the field of international exchange in recent years, it is imperative that these problems be addressed from a global perspective.
Based on this understanding, the Institute of Tropical Medicine, Nagasaki University, aims
to overcome tropical diseases, particularly infectious diseases, and the various health problems
associated with them, in cooperation with related institutions, to strive for excellence in the following areas:
１．Spear-head research in tropical medicine and international health
２．Global contribution through disease control and health promotion in the tropics byapplying the fruits of the research
３．Cultivation of the researchers and specialists in the above fields

General view of the Institute
Coverpage: Growth monitoring of young children in Savannakhet Province, Lao, P.D.R.
(Health Development Study in Lao, P.D.R.)

熱研案内パンフ（欧文）表紙２−３ CMYK 芦塚 山道 芦塚

背は２mm
（決）

Preface
The Institute of Tropical Medicine, Nagasaki University, established in
1942, is a unique government-assisted institution for the research on tropical
medicine, both in the basic and applied fields. Its reorganization led to thefirst collaborative institute in medical science in Japan in 1989, and designation as one of the Centers of Excellence in 1995 by Ministry of Education, Science and Culture. Present organization of the institute is composed of 3 major
research fields (11 departments, 1 domestic visiting department, 1 overseas
visiting department), 2 centers, and 1 clinical unit.
According to the first external review in 1996, the institute worked out
its Mission Statement as shown on a back cover. To fulfil our mission, we continue the research and other related activities. The highlights are as follows.
＊Activities on the Mission Spear-head research in tropical medicine and international health
１．Strategic researches have been conducted to develop the novel weapon against tropical diseases; analysis
of genomic structure of Japanese encephalitis and dengue viruses, structure and function of the receptors forbacterial enterotoxins, mechanisms for expression and activation of superoxide degenerating NADPH oxidase system, and immuno-genetical analysis of tropical diseases.
２．Epidemiological studies and control have been carried out on malaria, dengue fever / dengue hemorrhagic
fever, acute respiratory infections, Kaposi's sarcoma and schistosomiasis in Southeast Asia and Africa.
３．Environmental factors, such as vector and socio-economic problem, which cause the spread of tropical diseases in the developing countries have been studied.
＊Activities on the Mission Global contribution through diseases control and health promotion in the tropics
by applying the fruits of the research
１．When the world was suffering from a severe outbreak of SARS in 2003, the institute dispatched 3 researchers to P.R. china and other countries in respond to a request of WHO.
２．And in 2005, the institute dispatched the investigation team to make a survey of possible outbreak of infectious diseases in Indonesia and Sri Lanka, the countries that met disaster of tsunami.
Thus the staffs have given their technical co-operation to disease control program in developing countries as
WHO short-term consultants, JICA experts and other consultants.
＊Activities on the Mission Cultivation of the researchers and specialists in the above fields
１．Staffs of the institute conduct the doctorate degree course which belongs to Graduate School of Biomedical Sciences in Nagasaki University.
２．Since 1978, the institute offers a 3-month course of Tropical Medicine and Related Studies.
３．Since 1983, the institute holds one year training course for foreign participants entitled Research in
Tropical Medicine sponsored by JICA.
Based on the achievement mentioned above, in１９９３，Department of Virology has been designated as WHO
Collaborating Centre for Reference and Research on Tropical Viral Diseases, and since２０００the Institutehas played a role of core university in JSPS cooperative research program with Vietnam.
In２０
０
３，
Institute of Tropical Medicine and Graduate School of Biomedical Sciences made a joint application to the 21 st Century Center of Excellence Program supported by Ministry of Education, Culture, Sports,
Science and Technology. Our research program Global Control Strategy of Tropical and Emerging Infectious
Diseases successfully obtains a Governmet Grant of 5 years.
In 2005, the overseas research laboratories of the Institute of Tropical Medicine has been established in
Kenya Medical Research Institute, Nairobi, Kenya and National Institute of Hygiene and Epidemidogy, Hanoi,
Vietnam. The overseas research laboratories promise an extensive and longitudinal studies on tropical diseases.
In addition, the institute has a home page by which we educate the public why tropical medicine is important for the future well being of humankind and information on the tropical diseases in the world.
This pamphlet is one of our advocacy efforts to the public. It offers a brief but intelligible explanation on
our research activities and other related social activities. Any suggestions and supports will be gratefully appreciated.
August, 2005
Yoshiki Aoki M. D., D. M. Sc.
Dean and Professor
Institute of Tropical Medicine
Nagasaki University―１―

Contents
Preface…………………………………………………………………………………………１
Contents …………………………………………………………………………………………２
Historical Review ………………………………………………………………………………３
Successive Deans of the Institute……………………………………………………………４
Organizational Chart…………………………………………………………………………５
Collaboration research………………………………………………………………………６
Institute of Tropical Medicine Steering Committee………………………………………７
Institute of Tropical Medicine Collaboration Professional Committee…………………８
Scope of Activities……………………………………………………………………………９
Postgraduate School…………………………………………………………………………９Three-month Course on Tropical Medicine and Related Studies…………………………９Training Course in Research of Tropical Medicine …………………………………………１
０
Public Lectures at the Institute ………………………………………………………………１
０
Publications……………………………………………………………………………………１
０
The 21st Century Center of Excellence Program…………………………………………１
１
Department of Virology………………………………………………………………………１
２
Department of Bacteriology…………………………………………………………………１
３
Department of Protozoology…………………………………………………………………１
４
Department of Parasitology…………………………………………………………………１
５
Department of Thermal Adaptation…………………………………………………………１
６
Department of Host-Defense Biochemistry …………………………………………………１
７
Department of Pathology/Division of Clinical Investigation ………………………………１
８
Department of Internal Medicine……………………………………………………………１
９
Department of Preventive Medicine and AIDS Research…………………………………２
０
Department of Vector Ecology & Environment……………………………………………２
１
Department of Social Environment…………………………………………………………２
２
Department of Molecular Immunogenetics…………………………………………………２
３
Department of Internal Medicine（University Hospital） …………………………………２
４
Animal Research Center for Tropical Infections ……………………………………………２
４
Research Center for Tropical Infectious Diseases …………………………………………２
５
Central Laboratory ……………………………………………………………………………２
６
Administration …………………………………………………………………………………２
６
Number of Staff …………………………………………………………………………………２
７
Accounting …………………………………………………………………………………………２
７
Grant-in-Aid for Scientific Research from the Ministry of Education,
Culture, Sports, Science and Technology ………………………………………………………２
７
External Funding …………………………………………………………………………………２
８
Site and Buildings…………………………………………………………………………………２
８
Agreement of Educational, Scientific and Scholaly Exchange ………………………………２
８
Location map of the Institute of Tropical Medicine on Sakamoto Campusof Nagasaki University …………………………………………………………………………２
９
Telephone Number……………………………………………………………………………３
０―２―

Historical Review
The Institute of Tropical Medicine, Nagasaki
University was originally founded in March 1942, as
the East Asian Research Institute of Endemics, inorder to perform basic and applied studies on endemic diseases in East Asia. At the beginning, mostof its research activities were field studies in mainland China, performed by several department such as
Pathology, Bacteriology, Internal Medicine and Dermatology of Nagasaki College of Medicine. Unfortunately, all the facilities and research materials werecompletely destroyed instantaneously along with theMedical School by the atomic bomb which explodedon August 9 th, 1945. As a result, development of
the institute and its research activities were severely inhibited.
In April 1946, the institute was named as the
Research Institute of Endemics attached to Nagasaki
College of Medicine, and moved to Isahaya City in
May in order to resume its research activities. In accordance with the Act on the Foundation of National
Schools in May 1949, the institute was renamed as
the Research Institute of Endemics, Nagasaki University. Becauce of the severe flood in Isahaya City,
the construction of the new building in Sakamotomachi, Nagasaki City was started in 1960, and the institute moved to new building in April, 1961. At thattime, there were only two departments, Pathology
and Clinics, however, since 1964, new departments
were established every Year, such as Epidemiology,
Parasitology, Virology and at the end of 1966, thefirst extension of the building was completed.
In June 1967, according to the partial alterationof the Act on the Foundation of National Schools, thename of the institute was changed to the present one,in order to perform basic as well as applied studies
on tropical medicine. At the same time, the Depart-

ment of Internal Medicine of the institute with 20 bed
facilities was opened in the University Hospital. In
1974, Department of Bacteriology and ReferenceCenter as an attached facility were opened. In 1978,
the Department of Preventive Medicine suppoeted byvisiting staff and the Training Course of Tropical
Medicine were started. In 1979, Ward of Infectious
animals became Animal Research Center. In March
1980, the 2 nd extension of the main building was
concluded. In September 1983, the Training Course
in Research for Tropical Medicine by JICA was
opened. In 1984,Department of Protozoology was established. In July 1985, the 3 rd extension of thebuilding was completed. In 1987, Department ofMedical Entomology was established. In 1989, theinstitute was reorganized to a collaboration research
institute. In 1991, Department of Biochemistry wasadded. In March 1994, the 4 th extension of thebuilding was completed, and in April, 1994, the institute was reorganized to 3 research fields, Tropical
Microbiology, Pathogenesis and Clinical Sciences,and Environmental Medicine, with addition of 2 newresearch departments, Thermal Adaptation and Social Environment, and the institute has 12 research
departments at present. In 1995, the Institute wasdesignated as one of the Centers of Excellence inthe forefront of scientific research. In 1996, a newresearch department, Molecular Epidemiology, wasestablished under the Research Field of Microbiology to invite an overseas visiting professor. In 1997,
the Reference Center was abolished and in its place
the Information and Reference Center of Tropical
Medicine was established, then in ２００１，
it was abolished and in its place the Research Center for Tropical Infectious Diseases was established. In March２００３，
the ５th extension of the building was completed, symbolizing continuous consolidation and reorganization of the Institute.

―３―

Successive Deans of the Institute（East Asian Research Institute of Endemics）
Susumu Tsunoo

May．
４，
１
９
４
２-Aug．
２
２，
１
９
４
５

Kohei Koyano

Dec．
２
２，
１
９
４
５-Jan．
２
３，
１
９
４
８

Kiyoshi Takase

Jan．
２
４，
１
９
４
８-Aug．
３
１，
１
９
４
８

Noboru Tokura

Sept．
１，
１
９
４
８-May．
３
０，
１
９
４
９

（Research Institute of Endemics）
Noboru Tokura

May．
３
１，
１
９
４
９-Aug．
３
１，
１
９
５
８

Nanzaburo Omori

Sept．
１，
１
９
５
８-Nov．
３
０，
１
９
６
３

Hideo Fukumi

Dec．
１，
１
９
６
３-May．
３
１，
１
９
６
７

（Institute of Tropical Medicine）
Hideo Fukumi

June．
１，
１
９
６
７-Nov．
３
０，
１
９
６
９

Daisuke Katamine

Dec．
１，
１
９
６
９-Nov．
３
０，
１
９
７
３

Kaoru Hayashi

Dec．
１，
１
９
７
３-Nov．
３
０，
１
９
７
７

Tatsuro Naito

Dec．
１，
１
９
７
７-Nov．
３
０，
１
９
７
９

Daisuke Katamine

Dec．
１，
１
９
７
９-Apr．
１，
１
９
８
１

Keizo Matsumoto

Apr．
２，
１
９
８
１-Apr．
１，１
９
９１

Hideyo Itakura

Apr．
２，
１
９
９
１-Apr．
１，
１
９
９３

Mitsuo Kosaka

Apr．
２，
１
９
９
３-Apr．
１，
１
９
９
７

Akira Igarashi

Apr．
２，
１
９
９
７-May．
３
１，
２
０
０
１

Yoshiki Aoki

Apr．
１，
２
０
０
１-Up to the present―４―Organizational Chart
Department of Virology
Department of Bacteriology
Research Field ofMicrobiology

Department of Protozoology
Department of Parasitology
Department of Molecular Epidemiology(Overseas Visiting Professor)
Department of Thermal Adaptation
Department of Biochemistry

Research Field ofPathogenesis
and Clinical
Sciences

Department of Pathology
Department of Internal Medicine
Department of Preventive Medicine
and AIDS Research
Department of Vector Ecology& Environment
Department of Social Environment

Dean

Faculty
Meeting

Research Field ofEnvironmental
Medicine

Department of Environmental Physiology
Attached
Facilities

Animal Research Center
Research Center for
Tropical Infectious Diseases
Central Laboratory

Administration

General Affairs Unit
Collaboration Research Unit

University
Hospital

Clinical
Department

Department of Internal Medicine―５―These activities of the institute are expected toCollaboration researchcontribute to remarkable progress of tropical medicine.

The institute has conducted research in the field

The senior staff composed of professors of theof tropical medicine for the past ６
２ years since its

institute and the executive committee make plans forestablishment in１
９４
２．The institute was reorganizedresearch work. The steering committee and the col-to make extensive collaboration with other universi-

laboration professional committee composed of expe-

ties and institute in the field of interdisciplinary

rienced scientists coordinate the various collabora-

tropical medicine with molecular biology, entomology,tion researchs.

anthropology, social medicine, etc.

Collaboration Research Sytem

Steering Committee

The senior
staff（Professors）

Collaboration professional
committee

Executive committee―６―

Institute of Tropical Medicine Steering Committee
Nagasaki University

Professor Emetitus

Akira Igarashi

Duputy Director

Takeshi Kurata

National Institute of Infectious Diseases
International Medical Center

President

Takehiko Sasazuki

Keio University School of Medicine

Professor

Tsutomu Takeuchi

Research Institute for Humanity and Nature

Director

Toshitaka Hidaka

Research Institute for Microbial Diseases Osaka University
Professor

Takeshi Honda

National Museum of Ethnology
Director−General

Makio Matsuzono

Director

Tadashi Yamamoto

PegentShigeru Katamine

Graduate School of Biomedical Sciences

Dean

Koutaro Taniyama

Institute of Tropical Medicine

Dean◎Yoshiki Aoki〃

Professor

Kouich Morita〃

Professor

Toshiya Hirayama〃

Professor

Hiroji Kanbara〃

Professor

Michio Nakamura〃

Professor

Takuya Iwasaki〃

Professor

Koya Ariyoshi〃

Professor

Naoki Yamamoto〃

Professor

Masahiro Takagi〃

Professor

Tsutomu Mizota〃

Professor

Kenji Hirayama〃

Professor

Masaaki Shimada〃

Professor

Kazuhiko Moji〃

Professor

Osamu Kunii

The Institute of Medical Science
The University of Tokyo

Nagasaki University◎：Chairman―７―Institute of Tropical Medicine Collaboration Professional Committee
The Institute of Medical Science The University of Tokyo
Professor

Aikichi Iwamoto

Meiji Gakuin University The Faculty of International Studies
Professor

Akira Oki

Graduate School of Medicine The University of Tokyo
Professor

Kiyoshi Kita

Graduate School of Veterinavy Medicine, Hokkaido University
Professor

Ikuo Takashima

Chiba University Research Center for Pathogenic and Microbial Toxicoses
Professor

Kazuko Nishimura

Tsuda College Undergraduate Courses

Professor

Chizuru Misago

Kobe University Graduate School of Medicine

Professor

Haku Hotta

The Japan Center for Area Studies, National Museum of Ethnology
Assistant Professor

Kenichi Abe

Nagasaki University
Faculty of Fisheries

Professor

Kazumi Matsuoka

Graduate School of Biomedical Sciences

Professor

Isao Kouno

Institute of Tropical Medicine

Professor

Kouichi Morita〃

Professor

Toshiya Hirayama〃

Professor

Hiroji Kanbara〃

Professor

Yoshiki Aoki〃

Professor

Michio Nakamura〃

Professor

Takuya Iwasaki〃

Professor

Koya Ariyoshi〃

Professor

Naoki Yamamoto〃

Professor ◎Masahiro Takagi〃

Professor

Tsutomu Mizota〃

Professor

Kenji Hirayama〃

Professor

Masaaki Shimada◎：Chairman―８―Dental Science and Pharmacology were integrated

Scope of Activities

into the Graduate School of Biomedical Science consisting of four courses. All the departments in the In-

Based on the following research organization

stitute belong to the Course of Infection Research.

and intimate linkages with other research institutes

Students who want to study tropical medicine in theand universities, the institute aims at accomplishing

Institute are required to apply to the office of thea mission

Graduate School of Biomedical Science through theSpear-head research in tropical medicine

and international health .

professor of each department.

● To study comprehensively the tropical diseases
which are raging in the developing countries, re-Three-month Course on Tropical
Medicine and Related Studies

search organization of the institute consists of 3
major research fields which deal with the classicaltriad ofhuman-agent-environment determinantsof infectious diseases and Research Center for
Tropical Infectious Diseases.

The course aims to provide participating persons with a better understanding of the health prob-● The research of tropical medicine faces the inevi-

lems in tropics, to increase their ability to cope withtable fact that the bench is in the bush . There-

them, and to give a fuller knowledge of the cultures

fore the institute has a close linkage with the over-and the life of the people in tropics.

seas institutes in Asia, Africa and South Americas

Physicians and professionally qualified persons

and continues the joint studies. Memorandums ofworking in health and related fields may apply for ad-

academic exchange programs were signed between

mission to the course. Fifteen candidates are ac-

Nagasaki University and 8 overseas institutes.

cepted to the course in a year. The course consists ofSince the overseas research laboratories of the in-

１３weeks （June-August） of instruction and exami-

stitute has been established in Kenya Medical Re-

nation. Teaching is undertaken by the full-time staff

search Institute, Kenya and National Institute ofand guest lecturers.

Hygiene and Epidemiology Vietnam in 2005, theThe course provides lectures and laboratory andextensive and longitudinal studies on tropical dis-field practices in virology, bacteriology, protozool-

eases will be promoted. The exchange program un-ogy, parasitology, medical entomology, environmental

der the core university system of JSPS estab-physiology, biochemistry, pathology, genetics, epide-lished between our Institute and National Institutemiology, human ecology, social medicine, internalof Hygiene and Epidemiology in Vietnam in 2000

medicine, and geography and culture in tropics. Can-has been renewed in２
００５and lasts for 5 years more.

didates who completed successfully the course are● The prevalence of tropical diseases depends onawarded the Diploma in Tropical Medicine.

the geographic, social and economic factors.
Therefore the institute has established the special
research system which helps forward the multidisciplinary studies on tropical diseases.

Postgraduate School
In April, ２００２, the system of Doctor Courses in
Nagasaki University has been changed. In the new
system the Graduate School of Medical Science,―９―

Adomission ceremony in 2005

Training Course in Researchof Tropical Medicine

Public Lecturesat the InstituteArrangements for conducting the course in this In-

Annually, the Institute of Tropical Medicine holds

stitute are administered by Japan International Coopera-

public lectures for the citizens. The lectures address is-tion Agency, commissioned by the Government of Japansues pertaining to travellers to regions endemic to tropi-

to execute Technical Cooperation Programs from １９８３．

cal diseases. It is intended to prepare the public to main-

This course is conducted by the Government of Ja-

tain good health abroad. The other aim is to open our in-

pan as a part of its Technical Cooperation Programs fortellect and knowledge to the public.

developing countries with a view of contributing to upgrading their standards in tropical medicine and to pro-

Publications

moting friendly relations to the countries.
The purpose of this course is to help the control ofendemic and epidemic diseases infesting the Torrid Zone.

Tropical Medicine

Through the guidance of the staff of the Institute, the par-This is a quarterly journal with publications of origi-

ticipants will enrich their fundamental knowledge andnal articles from the Institute. The journal was first pub-practical techniques for various medical problems in thelished in March １
９５９ as Endemic Diseases Bulletin oftropics.

Nagasaki University . In１９６７，the name was changed

Individual participants will study on a selected subject in the responsible department for a year. Capacity ofto Tropical Medicine . The publication has been suspended since２００２.

each department is normally limited to one person.
Institute of Tropical Medicine, Nagasaki University
The first English guide for foreign visitors wasprinted in １９７１. A revised edition is published every
year.

Adomission ceremony in 2004

―１
０―

Our COE is coordinated by three institutions of Na-

The 21st Century Centerof Excellence Program

gasaki University and started in２
００４. Institute of Tropical Medicine will focus on the field based research andeducation. Graduate School of Biomedical Sciences will

Program Title : Global Control Strategy of Tropical andmainly perform laboratory based research. The infectious

Emerging Infectious Diseases

disease center will be responsible for the field or clinicalThe core courses to form the program : Institute of Tropi-

practice and trial. The three institutions will be coordi-

cal Medicine, Graduate School of Biomedical Sciences

nated to find and establish a new strategy for the control

Program Leader : Yoshiki Aokiof the disease.
We have established several field sites in Southeast-《Program Summary》
Global strategy for the control of tropical andemerging infectious diseases is urgently required by theworld community. This program is designed to help our
COE (Center of Excellence) to be one of the world top
five centers for advanced research and education in thisfield within 5 years under the support of Ministry of Education, Sports, Culture and Science, Japan.

ern Asia and Africa. For producing the experts in thisfield, we will set up the master degree course of tropical
medicine in addition to already existed Ph.D. course. For
the medical doctors' training, we opened a clinical training short course this year in the infectious disease centeras well as in the affiliated hospitals located in the tropicalcountries such as Philippines and Thailand.

Tropical
Diseases

Emerging
Diseases

Malaria,West Nile Fever, Drug
Prion Disease
Helicobacter
Schistosomiasis,
Resistant Bacteria
Pylori
Dengue Fever, Cholera
Developing Countries
Developed Countries

Collaborating
Exchange
Hospitals
Program
Chianmai University
Hosp（Thailand）
Institute of
St. Lukes Medical
Tropical Medicine・Center （Philippines） Graduate School of
Biomedical Sciences

Center for
Infectious
Diseases,
Nagasaki
University
Hospital

Basic Research
Field Bases
Collaborating
Translation Center organizations
NIHE（Vietnam）
JICA Ronbok
WHO, JICA,
Product Development CDC, NIH（Indonesia）
RITM（Philippines）
Liverpool
KEMRI（Kenya） Intervention Research Trop.Med
IMR （Malaysia）
Thammasat Univ.
Production of New Strategies
and Human resources
Global Control of Infectious Diseases―１１―Department of Virology
This Department has been conducting basic andapplied research on mosquito-borne flaviviral diseases such as Japanese encephalitis (JE), dengue fever (DF) / dengue hemorrhagic fever (DHF), as wellas SARS virus.
Analysis on the structure and function of JE and dengue viral genome
Nucleotide sequence analysis and molecular expression of JE and dengue viral genome have been
carried out together with long PCR techniques in order to study molecular epidemiology, epitope analysis, biological activity of nonstructural proteins, andvirulent viral gene responsible for viral pathogenesis.

Collaborating Center for Reference and Research on
Tropical Viral Diseases on 23 Nov. 1993. On 9 August 1994, the Inauguration Ceremony was held at
the Pompe Hall with of Dr. Han and approximately
120 guests in attendance, this was followed by the
WHO Workshop Epidemiology and Control on DF /DHF and JE . The Department has received WHO
fellows from Vietnam, Fiji, and the Philippines, anddispatched WHO short-term consultants on the subjects relevant to its terms of reference. Dr. Kouichi
Morita was appointed as the Regional Adviser on
Communicable Diseases, WHO-WPR, from 16 May
1995 to 15 May 1998. in March 2004, Dr Futoshi
Hasebe was dispatched to the WHO Western PacificRegional Office to collaborate in the global emerging
infectious disease control program.

Analysis on apoptosis induced by flavivirus infections.
Flavivirus infection induces apoptosis of the infected cells. Characterization of apoptosis and its
relation to pathogenecity has been studied in cell line
and animal model.
Development of rapid diagnosis of flaviviral diseases
Viral genome detection and identification by
PCR and LAMP methods, preparation of diagnostic
antigen from infected cell culture fluid, and simplification of IgM antibody detection have been carriedout.
Activities as a WHO Collaborating Center
Dr. S. T. Han, former Regional Director of
WHO Western Pacific Region (WPR) designated, theDepartment of Virology, Institute of Tropical Medicine, Nagasaki University was designated as a WHO

Newly identified JE neutralizing epitope 503

Professor
Assistant Professor
Research Associate
Research Associate
Research Fellow
COE Researcher
Guest Research Fellow
Guest Research Fellow
Senior Research AssistantTechnician
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Assistant Staff
Ronpaku Fellow
JICA Student

Kouichi Morita
Futoshi Hasebe
Shingo Inoue
Md Alimul Islam
Takeshi Nabeshima
Afjal Hossain Khan
Maria del Carmen Parquet
Edward G. Mathenge
Tomomi Yamaguchi
Kazumi Jodai
Hitomi Kinoshita
Thai Hong Thicam
Yu Fuxum
Leonora Salda
Mariko Oniduka
Paresh Sumatilal Shah
Nemani Telemaitoga Yuming Jin

P 2 Level laboratory―１２―

Department of Bacteriology
Our major research interest is to elucidate the
etiologic agents isolated from pathogenic bacteria
related to the worldwide emerging and re-emerging
diseases.
Studies on the cellular and molecular mechanisms of diarrhea induced by bacterial enterotoxins and Salmonella :Aeromonas sobria hemolysin is important in thepathogenesis of diarrhea caused by this enteropathogenic
bacterium .
Glycosylphosphatidylinositolanchored glycoprotein was identified as a receptor
for A. sobria hemolysin on Intestine 407 cells (Int. J.
Med. Microbiol (2005) 294, 427).
Focusing on the molecular mechanisms of the diarrhea induced by heat-stable enterotoxins (STa) ofenteropathogenic bacteria, we are studying 1) interaction of Escherichia coli heat-stable enterotoxin
with its receptor and 2) activation of guanylate cyclase (GC-C) by STa. Inflammation caused by Salmonella is also investigated (J. Biol. Chem. (2004) 279.
１２２
１
３ J. Immunol. (2004) 172：3051)
Studies on the pathogenesis of Helicobacter pylori :To investigate a potential mechanism of how H.
pylori establishes infection, we investigates the hostparasite relationships of H. pylori , focusing on vacuolating cytotoxin A (VacA) and Cag pathogenicity island (CagPAI).
１）
In cells transiently transfected with acarboxyl-terminal transmembrane domain (dominantnegative) syntaxin 7 mutant, VacA failed to induce
vacuolation, suggesting that SNARE is involved intheintracellular vacuolation induced by VacA (J.Biol.
Chem. (2003) 278:25585-25590).
2）
VacA induced bone marrow-derived mast cells
to produce proinflammatory cytokines, TNF-alpha,macrophage-inflammatory protein-lalpha, IL-1 beta,
IL-6,IL-10,and IL-13 in a dose-dependent mannerwithout causing degranulation (J. Immunol.(2002)168:

2603-2607)．
3）
Mice deficient in protein tyrosine phosphataseb do not show mucosal damage by VacA, although VacA is incorporated into the gastric epithelial cells to the same extent as in wide-type mice (J.
Biol.Chem(2003)278:19183) ibid (2004) 279: 7024,
ibid (2004) 279: 51013 Nat. Genet.(2003)33:375-381)．
4）
Human β-defensin-2 (hBD-2) is an antimicrobial peptide which belongs to one of the most important host defence system against bacterial infection
in several epithelial tissues. We studied the effect of
H. pyloli on the expression of hBD-2 mRNA in MKE
45 gastric mucosal cells. H. pylori , but not culture
filtrate, increased hBD-2 mRNA level in MKN 45
cells, whereas thus inductive effect of H. pylori was
not detected when Intestine 407 cells were incubatedwith H. pylori . Among the tested strains of H. pylori ,which lacks Cag PAI, did not induce hBD-2 mRNA in
MKN 45 cells. These results suggested that cag PAIof H. pylori is important for inductive expression of
hBD-2 mRNA through NF-KB activation in MKN 45
cells.
Exposure of MKN 45 cells to Salmonella typhimurium, S. enteritidis , S. typhi , and S. dublin ,but not Escherichia coli ML 35, resulted in remarkable induction of hBD-2 mRNA. (Cell. Microb. (2001)
3: 115 J. Immuml (2004) 173: 5398)
Studies on the development of cholera vaccine:The overexpression of fimbriae of Vibrio cholerae
O 1 is under study for use in cholera vaccine trial.

Cytotoxicity of VacA toxin through its binding toreceptor-protein tyrosine phosphataseβ―１３―Professor
Toshiya Hirayama
Assistamt Professor Akihiro Wada
Research Associate
Masahiko Ehara
Technologist
Mamoru Iwami
Postgraduate Student Masaaki Nakayama
Postgraduate Student Jyunzou Hisatsune
PRESTO Researcher Eiki Yamasaki
PRESTO Technician Kayo Maeda
COE TechnisianKumi Tamura

Laboratory

Study of trypanosomes

Department of Protozoology

１）Functions and expression mechanism of transsialidase.

Our main purpose is to clarify infection mecha-

２）Adaptation mechanisms of Trypanosoma species
to environments.

nisms of intracellular protozoan parasites.

３）Modification of infected host-cells by Trypano-soma cruzi .

Study of malaria parasites
１）Specific immune reaction in malaria.

Stady of Leishmania２）Surviving strategies of Plamodium falciparum in１）Characterization of Leishmania donovani isolates from Nepal.

mammalian hosts.
３）Epidemiology of human malaria.

２）Establishment of animal models of visceral leishmaniasis.
Other studies
１）Epidemiology of intestinal protozoan infection.
２）Biological chracterization of microsporidia.
Professor

Hiroji Kanbara

Assistant Professor

Haruki Uemura

Research Associate

Shusuke Nakazawa

COE Researcher

Mohammed Nasir Shuaibu

Technician

Miki Kinoshita

Technician

Megumi Morisaki

Postgraduate Student

Toshio Miyazaki

Postgraduate Student

Kishor Pandey

JICA Student

Ali Takadir Mtoro

Laboratory for culture

Plasmodia sporozoites from ruptured oocysts in
Anopheline mosquito

Amastigotes（left）and trypomastigotes（right）of
Trypanosoma cruzi―１４―

Department of Parasitology
The research activities are concentrated on filariasis, schistosomiasis, and intestinal helminthiasis
which constitute the major public health problems in
the tropics.
Filariasis

Brugia malayi (Cheju strain, periodic form),B.
pahangi and the vector mosquito,Aedes aegypti (Liverpool strain)have been maintained in the laboratory
for many years. Highlights of recent studies are as
follows.
１）Development of a simple and sensitive method for
determination of serum concentration of ivermectin(IVM) and diethylcarbamazine (DEC):IVM and DEC modified partially in their chemical structure successfully produced the antibody
against drugs. Therefore the serum concentration(5ng/ml)of IVM and DEC can be determined by EIA.
２）Screening of antifilarial drugs from medical
plants:Vernonia amygdalina from Africa, Neurolaena
lobata from Guatemala and Cardiospermun halicacabum from Thailand, were effective in vitro on B.
pahangi adult worms and microfilariae.
３）Epidemiology and control of bancroftian filariasis:
A research project was carried in Kwale, Kenya,in cooperation with Kenya Medical Research Institute (KEMRI) during the period of 1990 and 1996.
Transmission potential and morbidity were studied.
Mass-chemotherapy with combination of DEC andNaHCO３ was evalualed.
４）Chemotaxis of filarial infective larvae:
We first reported B pahangi infective larvae
show chemotaxis to serum. The peculiar chemotactic
movement, the signal transudation involved in chemotactic response and serum characteristics that cause
chemotactic response of larvae have been studied.

some strain of vector snails have been maintained in
the laboratory. Highlights of recent studies are as
follows.
１）Swimming behavior of miracidia:
cAMP is involved in the control of ciliary beating and chemotaxis of miracidia, and the vigorous
swimming of miracidia inside the egg-shell is a key
factor for hatching of miracidia.
２）Mechanisms of penetration of cercariae into skin:
The studies suggest the involvement of protein
kinase C in proteolytic enzyme release from cercariae.
３）Epidemiology and control of S. haematobium infection:
Since 1981, the research project on Schistosomiasis haematobia was carried out in Kwale, Kenya,in cooperation with KEMRI for 20 years. The highlights of our studies are human water contact study,
cercarial concentration in natural water, ecology of
Bulinus globosus , usefulness of urinary reagent
strips, new immunodiagnostic test (urine ELISA,
modified COPT) , effect of piped water supply, KAP
study (knowledge, attitude and practices), health education, morbidity studies using ultrasound, environmental modification for snail control, prevalence of
bladder cancer and liver fibrosis, and qualitative andquantitative studies on difficulty of urination in thecommunity.
Intestinal helminthiasis
Since 2000, epidemiologial studies on intestinal
helminthiasis has been taken up. The studies aim toshow that mode of transmission is different in countries and main determinant is human behaviour.
Professor
Research Associate
Technologist
Technician
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student

Schistosimoasis

Yoshiki Aoki
Kanji Watanabe
Mitsumasa Miura
Satomi Tominaga
Tomoharu Ohki
Teruyo Kusaba
Mayumi Abe
Xinsong Zhang

Schistosoma mansoni (Puerto Rican strain and
Kenyan strain), S. haematobium (Kenyan strain)andExamination of difficulty of urination by using Uroflowmeter in an endemic area of Kenya

Examination of contamination of soil by eggs and larvaeof intestinal helminth in Vietnam―１５―Department ofThermal Adaptation
The department was established in１
９９
４to study on
the influence and damage of tropical environment on
human and animals. Then study result is applied inprotection and care of tropical disease for improving
infection and symptom.
Study on short and long term heat acclimatization of humanOn the short term heat acclimatization, it experiment to expose Japanese to heat in environmental
chamber for period from spring to summer. They
sweat too mach and high electrolyte concentration in
the sweat for surplus reaction, so they have big damage as compensation of body temperature control.
Heat loss responses of Tropical inhabitants arestudied in the short term heat acclimatization. Their
nonevaporative heat loss by blood circulation are effective, and their sweat is a little with low electrolyte concentration as comparison with Japanese it.
Therefore, they sweat minimum volume, and haveheat tolerance(Left figure).
Victims by heat stroke decrease, who are mainly
children and old men. Society and economy develop
by ability adaptation for heat acquired, which increases working ability without discomfort and fatigue.
A study of effective defense method from ultraviolet
rays
Ultraviolet rays (UV) contained by Sun lightcause various damage in the living body, and UV is alarge quantity and strong power in the Tropical Zone
and the mountains in particularly. Therefore,thecreatures on earth acquired various defense methods
for ultraviolet rays harmful to body in a process ofevolution.
We have been promoting the study of defense
methods from ultraviolet rays in wild animals which
inhabit in a low latitude area, the desert and mountains (Right figure: black layer of body hair absorbs
UV) in particular.
For the purpose, we study effective defense
mechanisms for ultraviolet rays in wild animals, thenwe design the best defense method against ultraviolet
rays with nature and harmless.
The influence of change in biophylaxis functions induced by ultraviolet radiation to infection of tropical disease
Skin cancer occurs by strong ultraviolet radiation for a long term. The exposure to more little
mount of ultraviolet rays may be influence biophylaxis function to infection. UV in the Tropical Zone
are strong, and many persons suffer from infectious
disease. There are approximately 250 million patients with schistosomiasis in Tropical Zone.
In our experiment on infection of Schistosoma
mansoni cercariae to mouse, ultraviolet radiationgroup by ultraviolet lamp (UV-B) was statistical difference in the number of Schistosoma mansoni cercariae invaded into skin and recovery the adult
warms compared with nonirradiation group. We experiment the influence of ultraviolet rays in Sun
light on it now.
This study elucidates influence of ultraviolet
rays for infectious disease and contributes to the infectious disease control, in particular,in the Tropical
Zone with strong ultraviolet rays.
Associate professor (Additional post)
Nobu Ohwatari

Experiment of thermal sweating in the environmental
chamber―１
６―

Pika inhabiting the mountains of 3200!

strictly required TRTGNB (R=purine, N=any base,

Department of Host-Defense Biochemistry

B=not adenine, G paired with T) and 14-mer or
longer for binding. G can be replaced by deaminatedReserches in our laboratory are focused on theA, namely, hypoxanthine, suggesting deaminated C-6

molecular regulations of the phagocyte NADPH oxi-

is essential for nGTBP binding. Deamination of nu-

dase system that generates active oxygens essential

cleotide bases are increased by high temperature andfor killing invading microbes.

the repair of deaminated portions of DNA would be
more important in tropical area than other areas.

Selective expression mechaisms for gp 91phox, a core com-

Transitions appreciably occured more at TRTRNB

ponent of the oxidase

sites than at other sites in tumor supressor protein p

The phagocyte NADPH oxidase is composed of

53 exons, suggesting this particular sites were frag-membrane-integrated flavocytochrome b 558 contain-

ile in tumor-prone cells.

ing gp 91phox and p 22phox, and cytosolic components

esophageal cancer due to transitions at p 53 non-GpG

phox

phox

Relative frequency of. Upon phagocytotic stimu-

sites in Brazilian mate-drinkers was relatively

lation, cytosolic factors move to membrane to makehigher than that in world-wide patients. Cloning andan active complex with the flavocytochrome. Basedpurification of this nGTBP are now urgent issues inon genetic analysis of CYBB , the gene encoding gp

our laboraatory.

such as p 47

and p 67

91phox, in a patient with chronic granulomatous disease, we found that PU.1, a transcriptional activator,

Professor

Michiko Nakamura

bound to gp 91phox promoter position centered to bp -Assistant Professor

Futoshi Kuribayashi

inResearch Associate

Yoshito Fujii

neutrophils, monocytes, and B lymphocytes, but not

Research Assosiate

Shoichi Suzukiphox

53 was important for the expression of gp 91（…in suspension）

in eosinophils. On the other hand, GATA-1 bound toa position centered to bp -98 had an important role inTechnologist

Toshiyuki Moriuchi

the expression of the gene in eosinophils. We are

Secretary

Mizue Nakamura

now interested in the mechanism that can modulate
the expression of CYBB in selected types of cells
for improving primary defense system in inflammation and allergy.

A novel GT-mismatch binidng protein
In the analysis of a cis -element of gp 91phox promoter,we found a novel GT-mismatched DNA binding
protein. An addition of unlabelled competitor homoduplex with G/C at bp -177, generated, but noterased, a strong 'supershifted' band in EMSA using
the labelled probe with A/T at bp -177.

Newlypaired heteroduplex with the unlabelled upper standwith G at bp -177 and the labelled lower stand with T
at the same position recruited nGTBP. This protein―１７―Department of Pathology /Division of Clinical Investigation

Virus infections of the central nervous system.
Flavivirus encephalitis, such as Japanese encephalitis and tick-borne encephalitis, and rabies are

In１
９
７０，
the Late Professor Toyosuke WATAN-

still big problems in the southeast and east Asia . Re-

ABE classified tropical diseases into４groups:

cently, enterovirus ７１ infection among children is

１．Diseases caused by pathogens, uniquely present

frequently associated with serious neurologicalmanifestaions in these areas. We are investigatingin the tropical areas.
２．Diseases induced by environmental factors suchthe clinicopathological aspect of these infections andalso performing animal experiments to establish

as tropic climate.
３．Diseases specific for some habitants in thetropical areas due to their high susceptibility.
４．Diseases difficult to prevent in developing coun-

their pathogenesis and prevention.
Carcinogenesis in papillomavirus infection.
Neoplasms, dysplasia and condylomas of the mu-tries.
Now, we are investigating the pathogenesis ofcosa and skin are investigating for the presence oftropical diseases based on this concept and aim to es-

papillomaviruses using the molecular and pathologi-

tablish the fundamental basis of their prevention andcal methods. In addition, we are developing an animaltreatment.

model of mucosal carcinogenesis using hamster.

Activities

Virus infections of the respiratory tract.
Human cases with airborne-infections such as

Pathological diagnosis of infectious diseases.
We are developing various antibodies and molecular probes available for diagnosis of infectious
diseases on the clinical specimens obtained at cytology, biopsy, necropsy and autopsy. We are also per-influenza and measles are studied for pathological diagnosis and their pathogeneses.
Pathology of tropical diseases.

forming various animal experiments to obtain posi-

Epidemiological and histopathological studies

tive controls for this analysis and to analyze theirare being done in the southeast Asia for tropical dis-pathogeneses.

eases and its sequelae.

Professor

IWASAKI, Takuya

Associate Professor TORIYAMA, Kan
Research Associate

SENBA, Masachika

Research Associate

HAYASAKA, Daisuke

Research Associate

AGO, Masanobu

Postgraduate Student HATAGISHI, Etsuko

Legend: The central nervous tissue of a cynomolgus monkey inoculated with enterovirus７１(EV７１）． Left: Hematoxylin−eosin stain.
Right: Immunostaining for EV７
１capsid antigens.

―１
８―

Research Assistant

FUKUMA, Aiko

Technician

NAKAMURA, Masako

lar epidemiology and virology studies for a better understanding of HIV transmission and HIV pathogenesis.

Department of Internal Medicine
Main objectives of research activities in the Department of Internal Medicine are to understandpathogenesis of tropical and respiratory infectious
diseases and to improve diagnosis, prevention andtherapy for infectious diseases in developing countries. Various basic scientific research and international collaborative studies are on going as follows:
1. Respiratory infections
We are investigating factors causing refractory
respiratory infectious diseases, such as biofilm formation of causative pathogens and clearance mechanisms of apoptotic neutrophil by pulmonary macrophages. We also conduct studies on molecular epidemiology of pneumococcus, hemophilus influenza etc,
acquired immunity against these pathogens in thelung, mucosal vaccine development.

4. Pneumococcal vaccine study for HIV-infected individuals in Uganda
As a collaborative study with the Joint ClinicalResearch Center in Kampala, Uganda, we have been
evaluating the induction of specific antibody and opsonic activity in HIV-infected individuals after immunizing those with a 23-valent pneumococcal polysaccharide vaccine.
5. Acuter respiratory infections among pediatric patientsin Vietnam
In collaboration with National Institute of Hygiene and Epidemiology, we are conducting studies onclinical and bacteriological diagnosis, antimicrobial
susceptibility and molecular epidemiology.

2. Studies of dengue disease in the Philippines
In collaboration with St. Lukes Medical Centerand San Lazaro Hospital in Metro-Manila, the Philippines, we have been studying pathogenesis andclinical and epidemiology aspects of dengue diseases.
Our focus has been on mechanisms of thrombocytopenia, which is a characteristic feature of dengue
virus infection.
3. HIV cohort studies in northern Thailand
In collaboration with National Institute of
Health, Thailand and National Institute of Infectious
diseases, Japan, a large scale of cohort study targeting HIV-infected individuals and their spouses has
been established in Lampang Hospital, northern
Thailand. We are planning to facilitate further hostgene polymorphisms, molecular immunology, molecu-

Research on bacteriology in BSL２laboratory

Professor
Associate Professor
Research Associate
Research Associate
Technician
Technician
Secretary
COE Researcher
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student

Koya Ariyoshi
Kazunori Oishi
Takeshi Yamaryo
Kiwao Watanabe
Naoko Kitajima
Miki Magome
Rika Nogawa
Mariko Saito
Jun Koyama
Takayuki OikeToshitaka Sukizaki
Yoshiyasu YozaChen Meng
Chiharu Kaji
Hiroaki Yoshii
Keita Oma
Natsuki Matsumoto

Laboratory of biochemical research―１
９―

showing that actin-dependent clustering of the recep-

Department of Preventive
Medicine and AIDS Researchtors is involved in the retrovirus infection. The receptors, however, do not directly associate with actin.
We try to identify the cellular molecule that func-

This department was newly added to the insti-

tions as a linker between the receptor and actin.

tute in １
９７
８ as a research division open to visiting
professors from other universities and institutes. It

Application of HIV envelope gene to gene therapy

is run by concurrent research staff for the present.

HIV enters into target cells by fusion between

We have planned and started from August of ２００
２avirus envelope and cell membrane. This reaction isseries of fundamental research to answer the ques-catalyzed by envelope glycoprotein encoded by thetion how and what mechanisms human immunodefi-

viral genome. When the envelope gene is introduced

ciency virus and murine leukemia virus enter into

to susceptible cells expressing CD４and CXCR４，

host cells. In addition, we are studying the applica-

syncytium formation is induced by its membrane fu-tion of these retrovirus to human gene therapy.

sion activity, and die. Recently, CD４-independent
HIV has been isolated. When the envelope gene of theStudy on the mechamism of viral entry into host cells by

CD４-independent HIV is introduced to cells ex-

retrovirusespressing CXCR４but not CD４，syncytium and cell

Human immunodeficiency virus (HIV) is known

death was induced. It has been reported that CXCR

to be a causative agent for acquired immunodefi-

４is up-regulated in mammary tumor. This suggests

ciency syndrome. After the HIV recognizes CD４andthat the CD４-independent HIV envelope protein

chemokine receptor, for example CXCR４，
it enters

specifically induces cell death of mammary tumor

into target cells mediated fusion between virus enve-cells. We are studying the application of the CD４-

lope and cell membrane. Murine leukemia virus

independent HIV envelope as a novel therapeutic(MLV) recognizes CAT１as the infection receptor,

gene for mammary tumor.

and enters into host cells by same manner. It is most
likely that the environment around the receptors in-Visiting Professor

Naoki Yamamoto

fluences the infection efficiency. In this context, weVisiting Associate Professor Hironori Satoare studying the effect of receptor glycosylation andAssistant Professor

Yoshinao Kubo

lipid factors proximal to the receptor on the HIV and

COE Researcher

Masaru Yokoyama

MLV infection.

Technician

Chika Tominaga

On the other hand, there are some evidences

Laboratory for biochemical researchLaboratory for biochemical research―２０―larval indices. In the laboratory Aedes aegypti and

Department of
Vector Ecology & Environment

Ae. albopictus are studied on their ecological characters among geographical strains. Feeding behavior
and population dynamics of these mosquitoes also are

Main interest of the department is analysis ofenvironmental factors that affect the trasmission ofstudied in the laboratory and fields.
３．Vector control technique related studies

insect-borne diseases, and pursuing environmental
friendly vector control strategy.

Basic study of copepods as a hopeful biologicalcontrol agent against vector mosquito larvae. Bio-

１．Physiology and ecology of malaria vectors

chemical approach to insecticide registance in vector

A long-term monitoring on main vectors of ma-

mosquitoes.

laria has been conducted at several fields in Southeast Asian countries. Spatial and temporal changes

Professor

Masahiro Takagi

in larval habitats, vegetation, and the impact of hu-

Assistant Professor

Hitoshi Kawada

man activity on the environment are evaluated in re-

Research Associate

Nobuko Tuno

lation to abundance of vectors, host preference, and

COE Researcher

Toshihiko Sunahara

other population parameters. The GIS/RS is intro-

Secretary

Toshiko Ueno

duced as a new tool to analyze the environment. Geo-

Research AssistantKozue shimabukuro

graphical strains of several Anopheles are compara-

Technician

Chiaki Tsurukawa

tively studied by morphological, physiological, andTechnician

Emiko Kawashima

genetic approach.

Secretary

Junko Sakemoto

２．Ecology and control of dengue vectors

Postgraduate Student

Maiko Hasegawa

Epidemiological studies have been conducted at

Postgraduate Student

Tran Vu Phongseveral fields in Southeast Asian countries. Monitor-

Postgraduate Student

Yoshihide Maekawa

ing by oviposition traps and mark-release-recapture

JICA Student

Isaac Mwangi Kimani

experiment are performed to establish more realistic

Stereomicroscopic observation of mosquitoes

Ramp traps for collecting mosquitoes―２１―Department ofSocial Environment
Specific Features of the Department
This Department covers under the 9th tenure interdisciplinary field of Environmental and Social
Medicine related to health services and social welfare problems in developing countries.
Interdisciplinary approach includes studies in
Social Sciences and Humanities. Further, methods
and actual means of international cooperation toward
developing countries has been sought to utilize in order to promote inter-departmental linkage for information accumulated with specific analysis and professional response to the public particularly in thefield of infectious diseases diagnosis and control.
Under this context, basic and applied research
have been carried out in the following prospective
themes from the view point of environmental and social aspects for the purpose of promoting assistanceto minimize health problems in tropical areas:
Area of Research Activities:
１．Study and analysis on social (incl. life style, political and economical) background which regulates
frequency / areas / accumulation of diseases of thepresence of epidemics.
２．Study on the effect of individual and social environment toward endemic and epidemics.
３．Standardization of human security measures in
the field of health services from the view points ofnutrition and 3 Es ie.economy, environment andeducation.
４．Study on control of communicable diseases
among the regional and international health careprograms.
５．Study on quantitative and qualitative values of
medical and health services under the ODA ie. Official Development Assistance programs by Japanese government.

Dept. of Social and Environmental Medicine often
serves as a secretariat for Int’l Symposia.

６．Feasibility study on comprehensive information
filing and network system for the sake of promoting health and social welfare services in developing countries, by epidemics, by regions, by administrative measures.
７．Reformation and coordination of health manpower traning program / system to meet the needof tropical area in connection with Risk Management.
８．Comparative studies on the control of emerging
infectious diseases in tropical Asia such as West
Nile and SARS.
Specific themes of joint cooperative research
designated to the Department in FY 2004 under thescheme of Research Institute for Nationally JointUse are listed below. The Technical and Management Committee recommended that interdisciplinary
research collaboration should be realized from theviewpoint of middle and long-term range and managed
not only by single department but also by the whole
Institute as one of the important mandates.
Joint Research projects themes:a)Social and Environmental Diagnosis of Tropical
Diseases for its Control and Prevention.
b)Study on Social bases of health care systems in developing countries.
Noted results of research projects have often
been integrated and fully utilized in the forms of
seminar or symposium for covering valuable themes.
Professor
Research Associate
Research AssistantTechnician
Postgraduate Student
Postgraduate Student
Postgraduate Student
JICA Trainee

Tsutomu Mizota
Susumu Tanimura
Tomomi Ikeda
Natsuko Imaoka
Chizuko Suzuki
Qin Liang
Takeshi Yoda
Hld Thein

Joint Cooperative Research Members Join in the meetingfor preparing textbook.

―２２―２) Protective Immunity in falciparum malaria
HLA-Class I restricted CD 8 Tcell analysis in
the immunity

Department of
Molecular Immunogenetics
This department is focusing on the pathogenic
genetic factors of the host and the parasite in themost important tropical infectious diseases using
molecular biology and human genetics.
１. Schistosoma japonicum
１) Pathogenesis of hepatosolenic disease
Immnopathology controlled by HLA-ClassII
genes is analysed by T cell epitope, Tcell cloning, tetramer analysis, Cytokine network analysis, ELISPOT analysis, 4 color FACS, animalmodel of HLA Tg mini-pig system
Identification of pathogenic genes by Multiple
families (MF) genetic analysis
Association analysis between disease and immune related polymorphic genes２) Molecular analysis of protective immunity in humans
Protective antigens effective for humans aresearched by checking reactivity of superresistant individuals in China.
Experimental animal model (pig)Analysis of protective immunity in pig, and Vaccine development targetedto somula stage antigens.
Estimation of mRNA expression in somula by
SAGE method
３) Surveillance system
Development of novel methodology for the longterm surveillance
Environmental research by GIS/RS is introduced to Hilly type schistosomiasis project
２. Malaria
１) Pathogenesis of Severe malaria
Functional analysis of the susceptible TNFP
(TNF-alpha promoter) alleles to cerebral malaria

３. Trypanosoma cruzi
１) Pathogenesis of the complications
Human genetic factors to develop Chagas heart,or the Mega disease by using HLA-class I,
MICA, B, TNFP, and other relevant genes.
Pathogenicity of the parasite
By Comparisons between three different pathogenic parasite lines derived from human patientswith different clinical types, cardiac, digestive,
and no complication.
Biological variety of the parasite lines molecular basis of the difference between intracellualr
proliferative (Peru 1,2) and non-proliferative,(H 1, H 23) are analysed by 2 D２) Protective immunity
Identification of a resistant gene
Analysis of the human T cell immunity
Protection from transplacental fetal infection.
４. Dengu virus
１) Pathogenesis of the DHF (Dengue Hemorragic
Fever)
Host factors will be detected by the Populational genetic analysis of the patients with DHF
and non DHF.
StaffsProfessor
Associate Professor
Assistant Professor
COE Researcher
COE Researcher
Technician
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student
Postgraduate Student
JICA Student

Department of Molecular Immunogenetics

Kenji Hirayama
Nobu Ohwatari
Mihoko Kikuchi
Kazunari Ishii
Naoko Okuda
Junko Hayashima
Dujdow Songthamwat
Akiko Takaki
Ekhlas hamed Abdel Hafeez Abdow
Nguyen Thi Phuong Lan
Akiko Yamazaki
Saw Wut Hmone

Clean Room for Cell Cuture―２
３―

Department of Internal Medicine

Animal Research Center
for Tropical Infections（University Hospital）
The Department of Internal Medicine is locatedon the 12th floor of University Hospital. It specializes in the Respiratory and Infectious Diseases. We
treat patients with lung cancer, bronchial asthma,
pulmonary fibrosis, sleep disorder, tuberculosis (TB)
and other systemic infectious diseases, including“tropical” diseases. It has twenty beds and several
others in the TB isolated ward. We have a ward
round, clinical conference, and journal club every
week. Broncho-scopic examination is being conducted regularly. We are actively involved in various
clinical trials. The outpatient clinic is open two daysa week where we started a travel clinic in April 2004.
In addition to our educational duties for undergraduate medical students (lectures and bed-side teaching),
we have a postgraduate training program for generalinternal physicians and infectious disease specialists.
Professor
Associate Professor
Assistant Professor
Research Associate
Research Associate
Research Fellow
Research Fellow
Research Fellow
Research Fellow

Koya Ariyoshi
Kazunori Oishi
Hiroshi Watanabe
Hiroyuki Yoshimine
Yoshiko Tsuchihashi
Shoko Honda
Reiki Kuroki
Tsuyoshi Kuramoto
Reiko Mizutani

The center makes it the principal aim to ensure
the safety of animal experiments which deal with thepathogenic microorganisms and to build up the successful generation of experimental animals, microorganisms and parasites. The building consists of 7
breeding rooms for experimental animals, 2 laboratories, one breeding room for snails and insects, and
two P 3-level biohazard laboratories. The air pressure is kept to be always negative to avoid outflow
from inside even at entrance to building. Since thebuilding has the most thorough ventilation through
HEPA filter, any microbe cannot leak out to outsideof the building. The water used is given chlorinationand drained off. The breeding animals and experiments are done according to the Guideline for Animal
Experiment edited by Nagasaki University. The
laboratory animals bred in the center are mice, rats,
hamsters, gerbils, rabbits, snails and mosquitoes.
Professor and Director
Research Associate
Technician

Hiroji Kanbara
Tetsuo Yanagi
Junko Kawashima

Mongolian gerbil （ Meriones unguicalatus ）Clinical conference―２
４―poisonous marine animals.

Research Center for Tropical
Infectious Diseases

The center carries out eco-epidemiologicalstudies on tropical diseases by means of fieldwork at
the actual site of the problem. We also use computer

The Research Center for Tropical Infectious

science technology, such as the geographical infor-

Diseases, Which Inherited its history from the infor-

mation system, remote sensing and information ex-

mation and Reference Center of Tropical Medicine,changing system, which project the future of tropicalwas established in April 2001. According to the his-

infectious diseases from both local and global per-tory the center has three missions.

spective. One of our main interest is the role of hu-

The center functions as a museum of tropicaldiseases, which is unique in Japan. Next, the centerman behavior in the transmission of tropical infectious diseases.

also provides necessary information and references
related to tropical diseases to all the staff, graduate

Professor

Masaaki Shimada

students, researchers and trainees, as well as mem-

Professor

Kazuhiko Moji

bers of the public who visit the Institute. The third

Professor

Osamu Kunii

mission of the center is to contribute to the global

Assistant Professor

Akiko Matsuyama

control of the tropical infectious diseases.

We

Research Associate

Eiko Kaneda

analyze the factors that regulate the epidemics of the

Research Associate

Nobuyuki Nishikioridiseases to find appropriate control measure of the

Research Assistant

Kyoko Sakitani

infection.

Research AssistantKazuo Araki

Technician

Kiyomi Suda

Technician

Satsuki Kunikanebooks, maps, periodicals, pamphlets, films, videocas-

Postgraduate Student

Tomoko Kisu

sette tapes, photo slides, photographs, charts, exhi-

Postgraduate Student

Yoshiki Hamada

bition panels, animal specimens as well as pathologi-

Postgraduate Student

Yuko Nakao

cal tissue specimens. These materials are now being

Postgraduate Student

Akio Ohno

digitized and are provided to the public through cy-

Postgraduate Student

Sadako Nakamura

berspace. The center also gathers scientific, social

Postgraduate Student

Guoxi Caieconomic, and cultural information related to tropi-

Postgraduate Student

Tomoko Abe

cal diseases. Our current exhibitions consist of pan-

Postgraduate Student

Rieko Nakao

els of major tropical diseases, diarrhea diseases,

Postgraduate Student

Magafu Mgaywa Damas

acute infectious diseases, AIDS related diseases,

Postgraduate Student

Osuke Komazawa

References currently available at the center are

and specimen of parasites, vector arthropods andExhibition room

Schistosomiasis transmission site
(Collection of vector snails)―２
５―Central Laboratory

Administration

There are several equipments at this laboratory.

Kinichiro Makiyama, Head Official

It is open for collaboration research with all part ofGeneral Affairs Unit

Japan followings are the equipments now available.
Electron microscopies (TEM and SEM of jeol), a Ultramicrotome (Reichert), con-focal laser microscope
system(LEICADMIREZ),aflow

cytometer(FACScan), a cell sorter (FACSsatar plus), Laser
scanning microscopies (Bio rad MRC 600 and Zeiss
LSM), micromanipulation system (Nikon-Narishige
and Zeiss-shimazu), Bioimage analizers (Hamamatsu
Photonics, Bio rad GS-250 and Pharmacia Image
master), a peptide synthesizer (Millipore 600 E), a
peptide sequencer (Shimazu PPSQ-10), DNA sequancers(Perkin-Elmer 373-70

andTsukasa Harada, Chief
Naomiki Yamamura, Sub-Chief
Ami Noda, Staff
You Kanai, Staff
Junko Suenaga, Assistant Staff
Asuka Mtsuo, Assistant Staff
Tomoko Takenouchi, Assistant Staff
Mariko Hirano, Assistant Staff
Etsuyo Uchida, Assistant Staff
Mamiko Akagi, Assistant Staff
Kumiko Shimizu, Assistant Staff

Pharmacia

AFL), a DNA/RNA extraction system (Perkin-

Collaboration Research Unit

Elmer 341-30), a real-time surface plasmon detecter

Yasuo Sakanaka, Chief(Fisons IAsys), two P 3 rooms, Super sentrifugal

Fumiko Hashiguchi, Sub-Chiefmachine (optima L-90 K). with other equipments, ex-

Yumiko Matsumoto, Assistant Staff

periments on cell biology and histochemistry can be
carried out.

Professor and Chief

Kenji Hirayama

Research Associate

Akitoyo Ichinose

Research Assistant

Hitomi Horie

The TEM of electron microscope Laboratory―２
６―

Number of Staff(as of May, 2005)

Divisions

Professor

Assistant
Professor

Lecturer

Assistant

Sub total

Others

Total

Enrollment

13

4

4

18

39

8

47

Accounting
Revenue (in 2004)

Expedditure (in 2004)

Divisions

Amount(in thousands)

Divisions

Amount(in thousands)

Tuition and Matriculation Fee

1,853

Personnel expenses

566,026

Others24

the cost of equipment

352,688

Total

918,714

Industry-Academic Cooperation

66,541

Donation

14,342

Total

82,760Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology(in 2005)

Classification

Scientific Research on Priority Areas

Scientific
Research!

Scientific
Research!

Scientific
Research"

Scientific
Research#

Exploratory Research

Young
Scientists
"

Total

Number of Grants

3

1

1

6

3

2

2

18

Amount(in thousands)

17,4001,600

18,20023,700

3,600

2,300

2,900

69,700―２
７―External Funding(in 2004)

Divisions

Cooperative ResearchCommissioned Research

Grants and Endowments

Number of Sources

４件

７件

１８件

Amount(in thousands)

２，
９
７０

４
３，
８４４

１
４，
３
４２

Site and Buildings
Location
Buildings（!）

１
２−４Sakamoto１chome Nagasaki−city
Institute of tropical medicine
（７，
４
６
３!）

Animal Research Center（４９０!）

Agreement of Educational, Scientific and Scholaly Exchange
Name of organization of partner countries

Concluded date

Chiang Mai University (Thailand)

February，
１９８８Mahidol University (Thailand)

November，
１９９９Philippines University Diliman (Philippines)

April，
２００１

Institute of Hygiene and Epidemiology (Vietnam)

June，
２００１

Airlangga University (Indonesia)

January，
２００４

St. Luke's Medical Center (Philippines)

February，
２００４

SAH LAZARO HOSPITAL MEDICAL CEHTER (Philippines)

August，
２００４

KENYA MEDICAL RESEARCH INSTITUTE (KENYA)

November，
２００４

―２
８―

Location map of the Institute ofTropical Medicine on SakamotoCampus of Nagasaki University

PlaygroundGymnasium

Laboratory Animal Center
for Biomedical Research

Parking
Medical Materials
Center for Atomic
Bomb Casuality

Radioisotope
Center
Sub-Gate

Parking

Research Center for
Tropical Infectious Diseases
In part of the
1st,3rd and 4th Floor(

Main Building of
the Institute ofTropical Medicine
School of Medicine
AtomicDiseaseInstitute

Animal Research Center

Main Gate
MedicalBranchLibrary
AlumniHall

Commemoration
Hall

Pompe
Hall

Back GateN

for University Hospital

―２
９―

)

Telephone Number
Institute of Tropical Medicine, Nagasaki University ………………………………………０
９５（８４９）７８００
Extensions
Dean ………………………………………………………………………………………４７００

８４９‐７８０１

Head of Administrative Office ……………………………………………………………４７０１

８４９‐７８０２

Chief of General Affairs Unit ……………………………………………………………４７０２
General Affairs Unit ………………………………………………………………………４７０３

８４９‐７８０３

General Affairs Unit ………………………………………………………………………４７０６
General Affairs Unit ………………………………………………………………………４７０７

８４９‐７８０６

General Affairs Unit ………………………………………………………………………４７０８
Chief of Collaboration Research Unit ……………………………………………………４７０９
Collaboration Research Unit ………………………………………………………………４７１０

８４９‐７８０７

Facsimile …………………………………………………………………………………４７０５

８４９‐７８０５

Meeting Room ………………………………………………………………………… ４
７１１
Department of Virology
Professor …………………………………………………………………………４７３３

８４９‐７８２７

Associate Professor ………………………………………………………………４７３４

８４９‐７８２８

Information ………………………………………………………………………４７３５

８４９‐７８２９Facsimile …………………………………………………………………………４７３６

８４９‐７８３０

Department of Bacteriology
Professor …………………………………………………………………………４７３７

８４９‐７８３１

Lab．
９ ……………………………………………………………………………４７３８

８４９‐７８３２

Information ………………………………………………………………………４７３９８４９‐７８３３

Department of Protozoology
Professor …………………………………………………………………………４７４１

８４９‐７８３５

Associate Professor ………………………………………………………………４７４２

８４９‐７８３６

Lab．
３ ……………………………………………………………………………４７４３

８４９‐７８３７

Information ………………………………………………………………………４７４４

８４９‐７８３８Department of Parasitology
Professor………………………………………………………………………４７２８

８４９‐７８２２

Associate Professor……………………………………………………………４７２９８４９‐７８２３

Research Associate……………………………………………………………４７３０

８４９‐７８２４……………………………………………………………………４７３１

８４９‐７８２５

Information

Department of Molecular Epidemiology
Professor………………………………………………………………………４７７０

８４９‐７８６０

Department of Thermal Adaptation
Professor （Concurrent）…………………………………………………………４７２６

８４９‐７８２０

Department of Biochemistry
Professor …………………………………………………………………………４７５４

８４９‐７８４８

Lab．
１ ……………………………………………………………………………４７５５

８４９‐７８４９Lab．
２ ……………………………………………………………………………４７５６

８４９‐７８５０

Information ………………………………………………………………………４７５７

８４９‐７８５１―３０―

Department of Pathology

Extensions

Professor …………………………………………………………………………４７１９８４９-７８１３

Associate Professor ………………………………………………………………４
７２０

８４９-７８１４

Lab．
２ ……………………………………………………………………………４７２１

８４９-７８１５

Information ………………………………………………………………………４７２２

８４９-７８１６

Department of Internal Medicine
Professor …………………………………………………………………………４７４６

８４９-７８４０

Associate Professor ………………………………………………………………４７４７

８４９-７８４１

Information ………………………………………………………………………４７４８

８４９-７８４２

Facsimile …………………………………………………………………………４７４９８４９-７８４３

Department of Preventive Medicine and AIDS Research
Professor …………………………………………………………………………４７５１

８４９-７８４５

Research Associate ………………………………………………………………４７５１

８４９-７８４５

Information ………………………………………………………………………４７５２

８４９-７８４６

Department of Vector Ecology & Environment
professor …………………………………………………………………………４７１６

８４９-７８１０

Staff room ………………………………………………………………………４７１７

８４９-７８１１

Information ………………………………………………………………………４７１５

８４９-７８０９

Facsimile …………………………………………………………………………４７１８

８４９-７８１２

Department of Social Environment
Professor …………………………………………………………………………４７７４

８４９-７８６４

Information ………………………………………………………………………４７７５

８４９-７８６５

Information ………………………………………………………………………４７７６

８４９-７８６６

Facsimile …………………………………………………………………………４７７７

８４９-７８６７

Department of Environmental Pyhsiology
Professor …………………………………………………………………………４７２４

８４９-７８１８

Associate Professor ………………………………………………………………４７２５

８４９-７８１９

Information ………………………………………………………………………４７２６

８４９-７８２０

Facsimile …………………………………………………………………………４７２７

８４９-７８２１

Animal Research Center
Information ………………………………………………………………………４７６２

８４９-７８５６

Laboratory ………………………………………………………………………４７６３

８４９-７８５７

Research Center for Tropical Infectious Diseases
Professor …………………………………………………………………………４７７８

８４９-７８６８

Professor …………………………………………………………………………４７７９

８４９-７８６９

Professor …………………………………………………………………………４７５９

８４９-７８５３

Lab．
１ ……………………………………………………………………………４７１４

８４９-７８０８

Computer Room! ………………………………………………………………４７７８

８４９-７８６８

Information ………………………………………………………………………４７６０

８４９-７８５４

Central Laboratory
Electron Microscope Room ………………………………………………………４
７６５
FACS Room………………………………………………………………………４７６７
Section for Experimental Animals ………………………………………………４７６９―３
１―

８４９-７８５９

Location map of the Institute of Tropical Medicine,
Nagasaki University in Nagasaki City

INSTITUTE OF TROPICAL MEDICINENAGASAKI UNIVERSITY

Mt. Inasa

Ｎ

Ropeway

Nagasaki Bay

Urakami

fo

rK

og

ak

for Akasako−
OhashiuraHamaguchi-machi
Urakamieki-mae
Nagasaki−
Ohato

Igakubu-mae

Nagasakieki-mae

School of
Dentistry
University
Hospital

School ofMedicine

Urakami−tenshudo-mae

Isibashi
Tsukimachi

Prefectural OfficeInstitute of Tropical
Medicine

City Hall−−
Chuobashi−−
Kokaido-mae
Suwajinja-mae−
Shokakuji-shita

JR Kyushu
Streetcar
Main bus routfor Mogi

for Hotarujaya

TE

OF T R OPICA

THE I N S

Y・

DICINE

AS

FO

UNDED

AK

2
194

I UNIV

２００５

IT

G

A

熱研案内パンフ（欧文）表紙４−１! CMYK 芦塚 山道 芦塚 中村

JULY

・N

Published on July３
０，
２
０
０
５
Edited by Institute of Tropical Medicine, Nagasaki University
Printed by Showado Printing Co.,１００７‐２ Nagano machi, Isahaya８
５
４
‐
０
０
３
６，Japan

ME

TI

U

L

T

How to get the Institute
１．From Nagasaki Station （JR Kyushu）!Get on a bus (Nagasaki Bus, Line ８）at Nagasakieki-mae and get off at Igakubu-mae.
Five minutes walk from the bus stop.
"Get on a streetcar at Nagasakieki-mae（for Akasako, Line １or３）, and get off at
Hamaguchi-machi. Ten minutes walk from the streetcar stop.
#Ten minutes by taxi from the station.
２．From Urakami Station（JR Kyushu）!Twenty minutes walk.
"Five minutes taxi.
３．From Nagasaki Airport!Get on limousine at the airport（for Nagasaki）, and get off at Nagasaki-ekimae, andthen continue to１．
"Get on limousine at the airport（for Nagasaki）, and get off at Ohashi, and then twenty
minutes walk from the bus stop or ５ minutes by taxi.
#About one hour by taxi from the airport.
Location
１‐
１
２‐４ Sakamoto Nagasaki ８５２‐
８５２３
URL http://www.tm.nagasaki-u.ac.jp

ERS!背は２mm（決）