Keio University
Annual Report on Research Activities
2008– 2009

Keio University

Creating New Knowledge Through Practical Learning
The mission of a research university is to improve education and research,and their application to fields such as medicine, thereby contributing tosociety and improving the well-being of human kind. For Keio University,
this idea is encompassed in its founder Yukichi Fukuzawa’s ”spirit ofpractical learning,” which is at the core of the University’s activities.
Practical learning, in other words, means to understand the real truth ofthings through empirical sciences such as the humanities, social sciences
and natural sciences, and to solve problems based on this understanding. For
over 150 years, Keio University has upheld this tradition of applying
scientific empirical research to real world problems.
Japan is experiencing dramatic changes to the structure of its economy
and society: the population is aging at a pace unlike any other country and thestructure of the economy has also changed significantly through theglobal financial crisis. In such a time of great social and economic change,
Fukuzawa’s “spirit of practical learning” is of utmost importance. It is with thisspirit that Keio University has been a leader in creating new knowledge
and contributing to society at a world-class level.
With this tradition and a history of research achievements, Keio University has
always been engaging itself in new and improved research. This has been
made possible through a research support structure developed by
identifying demands and the restructuring of systems and organizations.
Initiatives include research management through a code of conduct andcompliance framework; joint international research and international
intellectual property activities; and funding for the development of young
researchers.
The purpose of this Annual Report on Research Activities, the seventh to be
published, is to disseminate information on the University’s research
activities. It also aims to further promote creative research and businessacademia-government collaboration while building the knowledge base of thenext generation. In addition to providing the latest statistical data, thisreport highlights current cutting-edge research and trends. We hope that you
will gain an understanding of Keio University’s research activities and its
potential in the future.

Professor Atsushi Seike
President Keio University

03 Campus Research Centers and Office Organization for
Research Advancement and Research Administration
04
04
05
07
08
09
10

Research Advancement and Support System
Organization for Research Advancement and Administration (ORAA)
Center for Research Promotion
Intellectual Property Center
Incubation Center
Keio Advanced Research Centers (KARC)
Office of Research Administration

11 Research PICK UP

c

o

n

t

e

n

t

s

Keio University
Annual Report
onResearch Activities
2008-2009

13
13
15
17
19
21
23
25
27

Introduction of Research Centers
Mita Campus
Hiyoshi Campus
Yagami Campus
Shinanomachi Campus
Shonan Fujisawa Campus (SFC)
Shiba-Kyoritsu Campus
Shin-Kawasaki Town Campus
Tsuruoka Town Campus

29
31
34
36
37

Introduction to publicly funded research
Global COE Program
Special Coordination Fund for the Promotion of Science and Technology
Core Research for Evolutional Science and Technology
Ministry of Education, Culture, Sports, Science and Technology (MEXT)
Grant-in-Aid for Scientific Research

38
42
44
45
46
47
48
49

Research Funds at Keio University in FY2008
Researchers at Keio University in FY2008
Intellectual Property and Technology Transfer
Awards for Research Activities, FY2008
Introduction to the Keio University research databases
Research-related Facilities and Libraries
FY2008 Financial Position

Access Information* This publication describes research activities from 2008 to 2009.
Titles and positions given from p. 4 onward were as at April 2008.

Campus Research Centers and Office Organization for Research
Advancement and Research Administration
CampusMita Campus

・Faculty of Letters (Year 2 to 4)
・Faculty of Economics (Year 3 and 4)
・Faculty of Law (Year 3 and 4)
・Faculty of Business and Commerce(Year 3 and 4)
・Graduate School of Letters
・Graduate School of Economics
・Graduate School of Law
・Graduate School of Human Relations
・Graduate School of Business andCommerce
・Law School

Hiyoshi Campus
P15-16

・Faculty of Letters (Year 1)
・Faculty of Economics (Year 1 and 2)
・Faculty of Law (Year 1 and 2)
・Faculty of Business and Commerce(Year 1 and 2)
・School of Medicine (Year 1)
・Faculty of Science and Technology(Year 1 and 2)
・Faculty of Pharmacy (Year 1)

Office Organization for Research Advancement andResearch Administration

・Institute of Cultural and Linguistic Studies
・Institute for Media andCommunications Research・Institute for Economic and Industrial Studies(Sangyo Kenkyujo)
・Institute of Oriental Classics (Shido Bunko)
・International Center・Teacher Training Center・Fukuzawa Memorial Center for Modern
Japanese Studies
・Keio Institute of East Asian Studies (KIEAS)
・Center for Japanese Studies
・Research Center for the Arts andArts Administration
・Global Security Research Institute (G-SEC)
・Research Institute for Digital Media andContent (DMC)

Office of Research Administration,
Mita Campus

・Institute of Physical Education
・Sports Medicine Research Center・Health Center・Keio Research Center for Foreign Language
Education
・Keio Research Center for the Liberal Arts
・Research and Education Center for
Natural Sciences
・SDM Research Institute・KMD Research Institute

Office of Research Administration,
Hiyoshi Campus

・Keio Leading-edge Laboratory of
Science and Technology

Office of Research Administration,
Yagami Campus

・Center for Integrated Medical Research(Research Park)・Center for Clinical Research・Keio University Hospital

Office of Research Administration,
Shinanomachi Campus

・Graduate School of Business
Administration (Keio Business School)・Graduate School of System Designand Management
・Graduate School of Media Design

Yagami Campus
P17-18・Faculty of Science and Technology(Year 3 and 4)
・Graduate School of Science andTechnology

Shinanomachi
Campus
P19-20・School of Medicine (Year 2 to 6)
・Faculty of Nursing and Medical Care
(Year 3)

Organization for Research Advancement and Administration P04

P13-14

Research Centers (Faculties, Graduate Schools, Institutes, and others)・Graduate School of Medicine

P21-22・Faculty of Policy Management (Year 1 to 4) ・Keio Research Institute at SFC
・Faculty of Environment and Information
Studies (Year 1 to 4)
・Faculty of Nursing and Medical Care
(Year 1, 2, and 4)

Office of Research Administration,
Shonan Fujisawa Campus

・Graduate School of Media and Governance・Graduate School of Health Management

Shiba-Kyoritsu
Campus
P23-24・Faculty of Pharmacy(Year 2 to 4 / Year 2 to 6)

The Group for Research
Administration, General Affairs
Office, Shiba-Kyoritsu Campus

・Graduate School of Pharmaceutical
ScienceShin-Kawasaki
Town Campus

Shin-Kawasaki Town Campus OfficeP25-26

Tsuruoka
Town Campus

・Institute for Advanced Biosciences

P27-2803 Campus Research Centers and Office Organization for Research Advancement and Research Administration

Tsuruoka Town Campus Office

Head Office of Research Administration P10

Shonan Fujisawa
CampusOrganization for Research Advancement
and Administration (ORAA)

http://www.oraa.keio.ac.jp/index-e.html
E-mail: oraa-jimukyoku@adst.keio.ac.jp

Advancement of Research at Keio University
Keio University believes that its mission of returning the fruits of research tosociety is important. Based on the principle of "Gakujutsu Sendo (leadershipfor scientific progress)", the University aims to make significant contributions
to international society in the 21st century through original and creative
academic research. Keio University promotes numerous advanced research
projects at six campuses: Mita, Hiyoshi, Yagami, Shinanomachi, Shonan
Fujisawa, and Shiba Kyoritsu.

SFC (Shonan Fujisawa Campus), the Shin-Kawasaki Frontier Research and
Education Collaborative Square in Kawasaki City, and the Institute forAdvanced Biosciences in Tsuruoka City.
Roles and Functions of the ORAA

Traditionally, Keio University has been deeply involved in collaborative
activities between industry, government, and academia. Activities such ascommissioned research, joint research, and personnel exchanges are mainly
undertaken at five research facilities: the Keio Leading-edge Laboratory of
Science and Technology (KLL) at the Yagami Campus, the Center for Integrated
Medical Research at the Shinanomachi Campus, the Keio Research Institute at

The ORAA is comprised of various Centers and Committees, including: theCenter for Research Promotion (CRP), the Keio Incubation Center (KIC), theIntellectual Property Center (IPC), the Keio Advanced Research Centers (KARC),
the Intellectual Property Mediation Committee, and the Research Ethics
Committee. Together with the Offices of Research Administration, ORAA
promotes and supports all aspects of research-related activities, from the startof strategic research to the transmission and contribution of results to society.
The major roles and functions of each organization in the ORAA are as follows.

Offices of Research Administration (p. 10)
Support research activities at all campuses

Keio Advanced Research Centers (KARC) (p. 9)
Supports advanced, interdisciplinary research activities

The campuses of Mita, Hiyoshi, Yagami, Shinanomachi, Shonan Fujisawa, Shiba-Kyoritsu,
Shin-Kawasaki, and Tsuruoka each have an Office of Research Administration. Each officesupports research oriented to the researcher, acts as an on-campus contact point forexternal organizations, and promotes research collaboration with the Organization for
Research Advancement and Administration (ORAA). Specifically, the Offices provide
information to researchers in areas such as research resources, research environments, andopportunities for research subsidies from inside and outside Keio University (public calls for
subsidy applications), and also offer a variety of other support services including
negotiations and completion of contracts for joint or commissioned research, managementof research expenses and research spaces, and compilation and presentation of research
results.

The Keio Advanced Research Center (KARC) flexibly establishes, improves or eliminates,
operates, and manages personnel for research centers with organizations that cut across all
University faculties and departments, and supports the revitalization of advanced,
interdisciplinary research activities. Each research centers use external capital as resources
for activities, and undertake these activities using a specified campus as a base (homecampus). As a rule, Centers are established over a period of limited years (Center formation
period). This limit on the period for the formation of Centers is expected to promote research
results and the development of the research itself, in keeping with the development ofresearch contents; for example, when a given formation period is complete, new research
centers can be formed to carry on that work, or new organizations can be created within theuniversity.

Intellectual Property Mediation Committee

Research Ethics Committee

When an inventor lodges an objection regarding a given patent application, the Intellectual
Property Mediation Committee acts as a mediator based on the Keio University Regulations
for the Handling of Inventions.

The Research Ethics Committee
coordinates and manages policies andregulations related to issues such as
research ethics and conflicts ofinterest. Its main goal is to create
Shinanomachi Office of Research Administration
Yagami Office of Research Administration
Center for Keio Frontier
structures that are capable ofHiyoshi Office of Research Administration
promoting fairness and safety in
Research and Education Shonan Fujisawa Office of Research Administration
Mita Office of Research Administration research activities in response to
Collaborative Square
Shiba-Kyoritsu Campus
demands from society, particularly(p. 25, 27)
Head Office of Researchwith regard to compliance problems in
Administration
While the University's main campuses
relation to university research
maintain the traditional functions ofactivities, and the conflicts of interest
research and education, The Frontier
Offices of Researchthat can arise in activities involving
Administration
Research and Education Collaborative
collaborations among industry,
Square (K-FRECS) functions as a basegovernment, and academia.
for cutting-edge, collaborative research
Keio
Advanced
Research
Keio Incubation Center
Centers (KARC)
based on cooperation with the(KIC)community, as well as essential
research that cuts across variousIntellectual Property Center
University faculties and departments.

Center for Integrated
Education System

Center for Research
Promotion (CRP)(IPC) (p. 7)
The Technology Licensing
Organization (TLO) for Keio
University

Intellectual Property
Center (IPC)

The Center for Integrated Education
provides administrative support in the
primary and secondary schools
affiliated with Keio University.

Keio Incubation Center (KIC) (p. 8)
Supports incubation activities throughout Keio
University
The aim of the Incubation Center is to be an organizationthat supports and advances new business creation
together with industry at each campus, from thepreliminary stage of education and research to the returnof research achievements to society. The Incubation Center
1) plans and examines systems and mechanisms (funding
support schemes,etc.) that are necessary to support new
ventures, 2) formulates rules and guidelines for incubation
activities, 3) conducts surveys and collects statistics for
incubation activities and ventures originating from the
University, 4) builds and maintains internal and external
incubation support networks, 5) and supports the
management of incubation facilities. In addition, the KIC
provides public relations, information on entrepreneurial
education programs, and contest management for
incubation activities and ventures originating from the Keio
University.

Organization for Research Advancement
and Administration (ORAA)

Center for Research Promotion (CRP) (p. 5)
Promote comprehensive between industry, government, andacademia
The Center for Research Promotion (CRP) plays the role of general producer forplanning and promoting integrated and strategic research efforts based oncollaboration between industry, government and academia. In addition, the CRP
serves as a gateway to coordinate collaboration between companies, universities,
and research institutes in Japan and overseas. CRP is responsible for advancing
interdisciplinary research and comprehensive research collaboration. Specifically,
the CRP advances joint research projects through discovering and combining
university resources that match business needs. It supports the application
process to obtain public funding on research themes together with industry. The
CRP manages university research grant-in-aid to support joint research between
industry, government, and academia. Through symposiums, it also advances
exchange and communication of research results with external organizations.
These activities are advanced through discussions with the CRP Advisory Board.

As Keio University's Technology
Licensing Organization (TLO), theIntellectual Property Center has a wide
range of responsibilities, including
management and operation of
intellectual property generated by the
University to promoting collaborations
with society based on that intellectual
property. Based on applications forinventions submitted by researchers,
the IPC closely examines patentability
and the potential for licensing, taking
into consideration the researchers'
concepts of practical applications. It
then makes selections, files patentapplications, and maintains andcontrols those successful patents.
These technology licensing operations
open the door to a wide range of otheractivities, including licensing of Keio
University's patented technologies tocompanies, the creation of newcompanies with foundations in
intellectual property rights, and joint
research with companies aimed atdeveloping products for practicalapplications.

Organization for Research Advancement and Administration (ORAA)

04

Center for Research Promotion

http://www.crp.keio.ac.jp/en/index.html
E-mail: crp@info.keio.ac.jp

Combined promotions targeting industry-governmentacademia collaboration

The Center for Research Promotion functions as a general contact point in the planning and promotion of comprehensive strategic research by industry,
government, and academia, and in collaborations with companies, universities, research institutes in Japan and overseas.
Specific activities include: purposing plans for technology exchanges with companies, universities, and external research institutes; promoting joint andcontract research; completing comprehensive collaboration contracts; promoting research that combines fields within Keio University; planningand hosting open symposiums; and securing outside research capital.

1 Collaborations with outside institutions
In order to promote collaborative creation with outside institutions, including companies, municipal governments, independent administrative agencies,
incorporated foundations, and other universities, The Center for Research Promotion supports the creation of infrastructures and systems by maintaining
information, human networks, and frameworks. It has already completed collaboration agreements and is undertaking activities with Nippon Telegraph andTelephone Corporation (NTT) and Kyoto University, and has established new collaborations during the current fiscal year as well.
(1) Collaboration agreement with Sony Corporation on the “Fostering of next-generation
scientists and engineers project” (November 4, 2008)
As a new form of industry-academia collaboration with Sony Corp., Keio University agreed on medium-term
collaboration with Sony Corp., through manpower exchanges, joint research, etc., in other to strengthen fosteringof human resources in the field of technologies that will be a driving force in the next generation. A press
conference was held to announce the agreement.
Based on this agreement, a variety of activities has begun including joint research and development project forcell applications by graduate students, internships, and the establishment of donated lectures. In the
future, taking advantage of Sony's advanced R&D capabilities as a global corporation and Keio University's
educational and fundamental research capabilities, Sony and Keio aim to roll out the industry-academia
collaborations with the strengths of both from a long-term perspective, and to contribute to the further
development of business and education communities.

At the joint press conference on the collaboration project(2) Implementation of the “Next-generation Web technology joint development program 2008” with Itochu Corp. (July 1, 2008)
Itochu Corporation, Waseda University and Keio University form a joint partnership to promote a student support and development program for future
entrepreneurs in the next generation web technology field. The goal of this program is to seek out and foster innovative, creative ideas and technologies that will contributeto the creation of next generation web technology field, and to support and foster students wishing to start up businesses in this field. The program is promoted througha collaboration of Itochu Corporation, Waseda University, and Keio University.
Using a contest style format, students of both universities are asked to proposals based on open mind thinking, and outstanding proposals are presented with awards
and research support. At the same time, practical assistance being given to the realization and the future commercial application of the planned proposal. Students whoachieved particular success were invited to Silicon Valley in the United States in March 2009.
(3) Completion of a collaboration agreement with RIKEN Japan (December 10, 2008)
Keio University and RIKEN concluded a new comprehensive partnership agreement towards the slogan”Creative intelligence, leading the world”.
Keio University and Riken signed a comprehensive agreement with a long-term view to the future, aiming
towards the creation of “intelligence to lead the world”. The agreement sets the groundwork forinterdisciplinary collaboration between the organizations across diverse areas of research and education throughthe shared development of human resources and coordination between administrative departments.
Specific activities have already begun; for example, Research Center for Human Cognition was established byresearchers from both institutes in April 2009.
(4) Completion of an agreement on the establishment of the Japanese-French Laboratory for
At the signing of the basic agreement
Informatics (JFLI) (December 2, 2008)
Five institutions - the National Institute of Informatics (NII), the Centre National de la Recherche Scientifique (CNRS), the University Pierre et Marie Curie (UPMC), theUniversity of Tokyo, and Keio University - completed an agreement regarding the establishment of the Japanese-French Laboratory for Informatics (JFLI). The goal ofthis laboratory is to promote joint research and research exchanges in the field of informatics. It is expected to act as a venue for active interactions andcollaborations between Japanese and French informatics researchers, and to generate substantial results.
(5) Completion of the basic agreement on the promotion of advanced medical development by the School of Medicine (Super special consortium forsupporting the development of cutting edge medical care), the City of Kawasaki, and the Central Institute for Experimental Animals (April 23, 2009)”Super special consortium for supporting the development of cutting edge medical care”, represented by Professor Hideyuki Okano of the Keio University School of
Medicine, the City of Kawasaki, and the Central Institute for Experimental Animals signed an agreement to collaborate in the establishment of a core life science researchfacility. The goal of this new facility will be to act as a bridge between fundamental research and clinical research and to promote innovative research in the field lifesciences in order to develop innovative medical treatments such as regenerative medicine targeting central nervous system. The results of this research will then be
used to improve the welfare of Japanese citizens and to revitalize industry. In the future, this new research facility will collaborate with research institutes,
pharmaceutical companies, venture companies, and other entities in promoting “Super special consortium for supporting the development of cutting edge medical care”
involving regenerative medicine targeting the central nervous system, in order to contribute to integrated and efficient activities fundamental research, preclinical trials,
and clinical trials.

05 Center for Research Promotion

2 The External Collaborative Research Creation FundThis new grant system, which was set up in
FY2008, uses technology seeds and researchresources within Keio University to build broad
ranging collaborative structures with external
institutes, and to support the start up of joint
research targeting important social and academic
issues on a scale that would have been difficult toachieve in the past.
Screening of recipients was conducted with anemphasis on the novelty of research activities(new research themes, new collaborative partners,
and new research teams) and on the social impact ofthe proposed research.
Six research proposals were selected in FY2008.
The selected research themes were presented at
symposiums and academic societies, and in theform of research papers. Further expansion anddevelopment is expected in the future, as thisresearch moves toward practical applications in
new drug development, clinical applications, andadvice to government agencies.

Researcher
Research Resources andTechnology Seeds

CRP Coordinator
Project Formation•External Collaboration Selection•Keio University Collaboration
System•Follow Up Activities

External Collaborative
PartnerCompany, Local Government,
Independent Administrative Agency,
Needs of Foundation,
Other University

Matching
CRP (Grants)
Research Funds: Up to 50% of
expenses required for research,with an upper limit of ¥10 million

J o i n t R e se a r c h

Example of Selected Research Project in FY2008
Research theme: Governance structures in a civil society
Research representative: Yoshiaki Kobayashi, Professor, Faculty of Law and Political Science
External collaboration partner: Fukui Prefecture
The goal of this research, which was conducted in collaboration with Fukui Prefecture, was to construct a systemdesign that would provide citizens with the incentive to effectively promote measures to prevent global warming.
On November 26, 2008, a symposium entitled “Joint research contributing to the global warming
environment” was held jointly with Fukui Prefecture at the Mita Campus G-SEC, as a venue for presenting
intermediate results. At this symposium, Governor Nishikawa of Fukui Prefecture gave a speech on
activities at the prefectural level, and Professor Kobayashi from the Keio University Faculty of Law and
Political Science gave a presentation of environmental contributions through Japan with a focus onelectrical power supply and demand, as well as research methods for visualizing these figures on a map andadvice in the creation of government policy. In March 2009, the “Global Warming and Environmental
Contribution Index” (Keio University Press) was published, introducing for the first time an Environmental
Contribution Index specific to each prefecture in Japan, which was one outcome of research over the past year,
and which drew a dramatic response from regional governments throughout the country.

Center for Research
Promotion
Research Funds:
Amount of Grant and MatchingAmount or MoreAt the symposium for announcing intermediate report results

3 Communicating research results to society and promoting research interactions through a symposium“IBM Day at Keio University ~Global Innovation to the Future~” (October 15, 2008)
It has hold to support global innovation and with various lectures and forum discussions for students on thenewest research and technologies.
Following a presentation on research and technologies that create innovations, there were parallelsessions including a forum for female students and foreign students on research activities andemployment, and a panel discussion “Generation Deep Dive” round up discussion about the future ofJapan featuring four students from Keio Univ., representatives of the Ministry of Economy, Trade andIndustry, economists, and consultants, who deliberated on the theme of “Education, Working styles, andPolitics.” Both these sessions resulted in active exchanges of opinions by all those present. An “IBMAwards” ceremony was also held, and two researchers from Keio University received awards.
At the panel discussion

Keio University and Kyoto University hosted a joint symposium at Kyoto University on the firstanniversary of seal an agreement. (December 4, 2008)
The symposium began with opening remarks from President Hiroshi Matsumoto, Kyoto University and Vice President Jun Murai, Keio University. Professors from both
Universities gave presentations on three fields where substantial results have already been achieved through joint research: life sciences, economics, and IT.
These three presentations gave a very clear picture of how the collaboration agreement has expanded and enhanced the collaborative relationship between Keio University
and Kyoto University, for example in terms of joint research. In the future, Keio University and Kyoto University will strive for broader and deeper collaborations in
education, research, and human resources.
The 5th Keio University Advanced Science and Technology Symposium: “Future Medical
Research made possible by iPS cells” (February 4, 2009)
A symposium on the outlook for clinical applications of iPS cells was held in the West School Building Hall on
the Mita Campus. Lectures were given by researchers representing four bases of research in iPS Cells(induced pluripotent stem cells), including Professor Hideyuki Okano of the Keio University School of
Medicine and Professor Shinya Yamanaka of Kyoto University, as well as numerous others on the front linesof this field, representing NPOs, companies, academism, government, and organizations for patients with spinal
disorders. About 900 persons participated in this very successful symposium, including researchers,
students, patients’ organizations, and regular citizens.
Symposium Lectures

Center for Research Promotion 06

Intellectual Property Center
Technology transfer activities

http://www.ipc.keio.ac.jp/
E-mail:toiawasesaki-ipc@adst.
keio.ac.jp

Keio University IPC Activities
Objective: Give full play to “Research results” in developing businesses
Through the transfer ofintellectual property andtechnology

The transfer of technologies from universities to the industrial world
began with the enactment of the “Act on the Promotion of Technology
Transfer from Universities to Private Business Operators” in August
1998. Keio University established the Intellectual Property Center in
November 1998, and has undertaken leading activities aimed atreturning the benefits of research created by the university as an
authorized Technology Licensing Organization (TLO) to society in theform of products and technologies.
In an environment of intense global competition in the 21st century, theenterprise development structure is becoming more selective andfocused. At the same time, the third vehicle of return and the solutions inadvanced research fields that contribute to future commercial
applications both fall in synch with industry's expectations towards
universities.
To develop these activities even further, the Intellectual Property
Center is working on deepening research in Keio University andextending it to businesses from an international perspective.

Expand and broaden the research efforts of
Keio University
Invigorate the University environment

Keio University
Research
contract

Research

Education

IndustryAward

PatentProtection

Opportunities forexchange

Technology
Transfer

LicenseApprovalCompany
Start ups

Joint
Research

Follow UpIntellectual Property Center• Integrated IP/technology transfer system• A comprehensive program that includes
support for research contract, venture
start ups, and information exchange

Teachers, staff, and students are given the opportunity to interact withintellectual property, with the goal of offering practical, real-world
education and enhancing the dynamism of Keio University.

1 Promoting intellectual property and technology transfer activities
Our goal is to return expanded benefits of research results at Keio University to society bytransferring technologies to industry in Japan and around the world. This includes all aspects oftechnologies, including materials and knowhow with a particular focus on copyrights for
programs and patents created by researchers in the various faculties and departments on Keio

University’s campuses.
Technology transfers are conducted in three forms: (1) Licensing to companies; (2) joint
research with companies based on Keio University’s intellectual property; and (3) the creation ofventure companies based on Keio University’s intellectual property.

2 Creating a venue for information exchanges between industry and academia(1) Leading Innovation Network (at G-SEC)
The “Leading Innovation Network,” a series of gatherings to introduce technologies in various
technology fields, was established to transfer research results from Keio University to industry
in the form of concrete technologies.
- Gathering held on October 30, 2008 (Engineering field)“Chemical sensing materials and chemical sensors”; Professor Koji Suzuki; Department
of Applied Chemistry, Faculty of Science and Technology“Development of diamond electrode sensors”; Associate Professor Yasuaki Einaga,
Department of Chemistry, Faculty of Science and Technology“Functionality of polymers made from diamond-like carbons”; Associate Professor
Atsushi Hotta, Department of Mechanical Engineering, Faculty of Science and Technology- Gathering held on January 16, 2009 (Bio field)“Cancer treatments targeting molecules that simultaneously control cancer
metastasis and immunosupression”; Chie Kudo, Assistant Professor, School of Medicine“3rd Generation treatments for Alzheimer’s disease which control the death of nerve
cells”; Masaaki Matsuoka, Associate Professor, School of Medicine“The new world of medical treatment and bio made possible by puromycin
technologies”; Professor Hiroshi Yanagawa, Department of Biosciences and Infomatics,
Faculty of Science and Technology(2) Venture Private Conference (at G-SEC)
This conference, held at the Mita Campus G-SEC on July 2-3, 2008, and January 27-28, 2009,
included presentations by venture business managers on business strategies and the outlook
for the future, as well as introductions of specific businesses.

(3) Forums and symposiums
1. International Technology Transfer Forum (at G-SEC)
The International Technology Transfer Forum was held on October 10, 2008, on the theme of“Experiences in research collaborations and technology transfers with overseas institutions,and expectations of universities.” The Forum welcomed Yoshio Matsumi, Senior Advisor andGeneral Manager of the Innovative Technology Business Development Office at Itochu
Corporation.
2. International Industry-Government-Academia Collaboration Symposium(at the North Building Hall)
An International Industry-Government-Academia Collaboration Symposium entitled “The future
outlook for Global Industry-Government-Academia Collaboration: 10 years of activities at the
Keio University Intellectual Property Center” was held on December 16, 2008.
On March 17, 2009, another International Industry-Government-Academia Collaboration
Symposium was held, entitled “Current status and issues in technology transfers at Japaneseand American universities: American university TLO practices that we want to hear about once
more.” This Symposium welcomed speakers and panelists including the President of Todai TLO
Ltd. and TLO specialists from Stanford University and the University of Wisconsin in the U.S.
3. Private University Industry-Academia Collaboration Forum(at the Ono Memorial Lecture Hall, Waseda University)
The “5th Kanto-Kansai 10 Private University Industry-Academia Collaboration Forum:“Innovations and Inter-university collaborations” was held on November 28, 2008, as a joint
project by 10 university TLOs in the Kanto and Kansai regions: Chuo University, Tokyo Denki
University, Nihon University, Meiji University, Waseda University, Kansai University, Kwansei
Gakuin University, Doshisha University, Ritsumeikan University, and Keio University.

3 Intellectual Property Center Awards/Education(1) Intellectual Property Center Awards
The Intellectual Property Center Award was established in 2000 and is presented each year topromote the activities of the Intellectual Property Center within the University, and tocommunicate the University’s new initiatives to society. The 9th Award, in 2008, waspresented to Professor Yasuo Ikeda and Associate Professor Masataka Kuwana of the Schoolof Medicine, for creating a “Thrombocytopenia (reduced blood platelet count) diagnosis
technology.”(2) Intellectual Property Center courses
A course on “General theory of intellectual property” was established at the Intellectual
Property Center from 2008. This course is operated using capital from the Nateglinide
Memorial Toyoshima Research and Education Fund to provide educational opportunities inrelation to intellectual property.

4 Industry-Government-Academia Collaboration Strategy Development
In 2008, two fields were selected by the Ministry of Education, Culture, Sports, Science andTechnology (MEXT) as part of its Industry-Government-Academia Collaboration Strategy
Development program: “Promoting international Industry-Government-Academia Collaboration
activities,” and “Strengthening intellectual property activities related to iPS cells.” TheIntellectual Property Center has taken a central role in the following contracted business
operations in collaboration with the Organization for Research Advancement andAdministration (ORAA) Incubation Center and the Center for Research Promotion.
(1) Promoting international Industry-Government-Academia Collaboration activities
1. Model themes include handling of international research results, establishment ofconfidentiality and other rules, establishment of international intellectual property strategies,
and support for international research activities
2. International forums and symposiums
2. a. International Technology Transfer Forum
2. b. International Industry-Government-Academia Collaboration Symposium
3. Collaborative investigative research on incubation seeds using the SOI Asia Network

07 Intellectual Property Center

4. Creating English-language videos introducing research and patent seeds, and using an
English-language intellectual property/research PR website to secure international joint
research and contract research and to conduct international technology transfer activities(2) Strengthening intellectual property activities related to iPS cells
An iPS cell research intellectual property strategy team was set up in April 2008, to strengthen
IP activities at the Keio University Center, which is one of four research centers in the Ministryof Education, Culture, Sports, Science and Technology (MEXT) studying iPS cells and related
issues. The team’s activities include:
1. Rapid and accurate acquisition of intellectual property (seeking out and securing intellectual
property)
2. Intellectual property acquisition strategy measures and support for research from an
intellectual property perspective
3. Support in enhancing research environments related to intellectual property
4. Support in technology transfers and the completion of contracts
5. Information exchanges and collaborations with Kyoto University and other iPS cell research
institutions in Japan

Incubation Center

http://www.kic.keio.ac.jp/
E-mail: incu-jimu@adst.keio.ac.jp

Supporting and promoting incubation and fostering
people with "Entrepreneurship"
Since its establishment, Keio University has been giving backknowledge to the community through education and research activities.
"Giving back knowledge to the community" is at the heart of university
activities aimed at fostering people with entrepreneurship and theprocess of creating new business by sublimating the results generated byuniversities into sustainable frameworks in the form of business (theprocess of "Incubation"). These activities should therefore beundertaken as an integrated part of research and education activities,
rather than being separated from them.
The way in which a university gives back knowledge to the community
should not be limited to the traditional approaches of "Providing
knowledge and manpower." Universities must promote incubation
based on a stance of "Collaborating with industry from the stage ofeducation and research, and taking responsibility even up to thepractical application of the results."
Based on these policies regarding the creation of new business, the
KIC and the each campus works in collaboration with industry from theeducation and research stage through to the point where the results
are returned to the community, with the goal of promoting the creation of
new business and the creation of economic and social value.

1 Support for university-based venture companies

and maintenance of a network for supporting incubation activities
2 Creation
inside and outside of Keio University

The Incubation Center continues to provide support and information; in September 2008, it
published a pamphlet in Japanese and English summarizing its activities, and in December, it
published an “Entrepreneurship Handbook for University Teachers and Students,” which offers
a wide range of information related to entrepreneurship.

The Incubation Center has created and maintains a network for support activities throughinformation exchanges and collaborations with organizations inside and outside of Keio
University. Following is an outline of specific activities in FY2008.
(1) Information exchanges with an audit corporation (AZSA & Co.)(2) Information exchanges with venture-capital organizations (Nippon Venture Capital Co., Ltd.;JAFCO Co., Ltd., etc.)(3) Information exchange with the Shonan Fujisawa Office of Research Administration, the SFC
forum, KIEP, MM Co., Ltd., and other incubation partners, positioning of these organizations, andconfirmation/coordination regarding these collaborations(4) Creating an organization that supports various Forums:- Cooperation with the SFC-IV Entrepreneurship Forum- Cooperation with the KIEP Forum(5) The SOI Asia Business Platform Limited Liability Partnership, which had been planned andstudied since 2007, was formally established in June 2008.
Keio University and the SOI Asia Business Platform Limited Liability Partnership completed acontract and began studying the creation of incubation business in Asian networks.

Incubation Center Pamphlet

At the end of FY2008, a total of 61 venture companies originating at Keio University had been
established with the involvement of teachers and students (17 of these venture companies
were established based on intellectual property).

Top universities creating venture companies in 2008
University

01
02
03
03
05
05
07
07
07
07

Waseda University
Kyushu University
The University of Tokyo
University of Tsukuba
Keio University
The University of Digital Content
Hokkaido University
The University of Tokushima
Kanazawa University
University of Fukui

No. of companies

6
5
4
4
3
3
2
2
2
2

Top 10 universities establishing venture companies in 2008 (cumulative base)No. of companies

Last year order

125
76
75
74
64
57
57
55
51
45

1st
5th
2nd
3rd
4th
7th
9th
8th
6th
11th

Ranking

University

01
02
03
04
05
06
06
08
09
10

The University of Tokyo
University of Tsukuba
Osaka University
Waseda University
Kyoto University
Tohoku University
Tokyo Institute of Technology
Kyushu University
Keio University
Kyushu Institute of Technology

Knowledge
Manpower

Industry also
participates in learningand researchIntegration ofindustry andacademia

Data
Fund
LearningIndustry:
Practical applications
Traditional division of
responsibilities

Academics has a
responsibility topractical applications

Practical
applications

Ideal form of collaboration
between industry and academia

3 Support in the operation of incubation facilities (Keio Fujisawa Innovation Village)

Entrepreneurship Handbook for University
Teachers and Students

Ranking

Research

Academia: Research

At the end of March 2009, Keio Fujisawa Innovation Village had 23 tenant organizations(including individuals). (12 of these organizations are University related, six are local venturecompanies, and five are venture companies from outside the city.) Activities undertaken withinthese facilities include the establishment of companies and support in finances, accounting, anintellectual property by incubation managers; venture business advice meetings by outside
specialists; introductions of university researchers; and support in acquiring various types of grants
and subsidies. Through these support activities, two organizations from Keio Fujisawa
Innovation Village were established as corporations in FY2008 (cumulative total: 11
companies).

4 Meetings, etc.
(1) Incubation steering committee staffs were assigned from each campus, and committee
staff meetings were held in July and March.
(2) An Incubation Center Director's Office and a space for the execution of Administrative
Division activities were established in January 2009 within the Organization for Research
Advancement and Administration (ORAA) Secretariat on the Mita campus.
in the Industry-Government-Academia Collaboration Strategy
5 Participation
Development program
In 2008, the following operations were undertaken as part of Industry-Government-Academia
Collaboration Strategy Development program by the Ministry of Education, Culture, Sports,
Science and Technology (MEXT) to survey, study, and establish “SOI (School on Ineternet)
Asia” as a test case for venture capital business through collaborations between the Center for
Research Promotion and the Intellectual Property Center in the Organization for Research
Advancement and Administration (ORAA).
1. Surveys to seek out seeds for new business in Asia (including on-site surveys at five
universities in Asia)
2. Meetings inviting representatives of five Asian universities (held in Indonesia)
3. Operation of a Business Idea Contest
4. Management of course contents for Asian universities (including intellectual property
education in collaboration with the Intellectual Property Center)5. SOI (School on Internet) Asia distance education project (development of new cases,translation of Japanese cases into English, and renewal of the homepage)*The above figures show the number of venture companies currently active.
Incubation Center 08

Keio Advanced Research Centers (KARC)

http://www.karc.keio.ac.jp/index-e.html
E-mail: karc-jimu@adst.keio.ac.jp

Supporting revitalization of advanced, interdisciplinary research activities

Keio University established the Keio Advanced Research Centers (KARC) in February, 2007 in response to an increasing number of requests to form new types of research
centers (or education and research centers) that merge and connect a wide range of research fields.
KARC flexibly establishes, improves or eliminates, operates, and manages personnel for research centers with organizations that cut across all University faculties anddepartments, and supports the revitalization of advanced, interdisciplinary research activities.
The research centers use external capital as resources for activities, and undertake these activities using a specified campus as a base (home campus).
As a rule, Centers are established over a period of five years (Center formation period), but this period can be extended to 10 years if conditions (capital, etc.) are met.
This limit on the period for the formation of Centers is expected to promote research results and the development of the research itself, in keeping with thedevelopment of research contents; for example, when a given formation period is complete, new research centers can be formed to carry on that work, or neworganizations can be created within the university.

1 Unique features of KARC
Thirty-four Centers were created after the establishment of KARC. Five of these Centers havealready completed their activities. Following are some of the unique features of KARC:• It forms advanced, strategic research centers at Keio University.
• It proposes and develops new fusion areas not restrained by frameworks ofexisting academic disciplines.
• It constructs organizations that are capable of handling dynamic research
projects.
• It closes research centers to enable them to efficiently complete their missions.
KARC has also introduced a unique concept called "Starting Up Center (SU)". It is a preparatory
center for research groups with clear academic objectives and concrete plans to use in setting up
a more formal research center later. In 2008, three centers among 11 were set up under thisscheme.

Positioning of the various
Centers in KARC

Center for Research
Promotion

Organization for
Research Advancement
and Administration(ORAA)

Keio Advanced
Research Centers(KARC)

Intellectual Property
CenterKeio Incubation Center

CenterB Center (E Campus)(Education andresearch center)

A Center (D Campus)(Research center)

C Center (F Campus)(Research Center)

2 The Aim of KARC
KARC is an interface for a wide range of centers that are representative of Keio University. It operates these centers in a wide range of formats, including Global Centers of Excellence and centers fundedby Japanese public funds (such as the Special Coordination Fund for the Promotion of Science and Technology), as well as EU Centers of Excellence and centers undertaking joint research with private
corporations. Campuses hosting such research centers can be found on virtually all of Keio University's campuses: Mita, Hiyoshi, Yagami, Shinanomachi, Shonan Fujisawa, and Shin-Kawasaki.
KARC seeks to utilize the unique characteristics of the centers' respective faculties and campuses and merging those characteristics to create new frameworks for and approaches to carrying out researchat Keio University.

Centers within KARC

(as of June 23, 2009)

Center Name

Center Director

PeriodHome Campus

Center for Human Metabolomic Systems Biology

Professor, Graduate School of Medicine

Makoto Suematsu

2007/02/01〜2012/03/31

Shinanomachi

International Center of High-Level Global Cooperation for Leading-Edge Platform on Access Spaces

Professor, Graduate School of Science and Technology

Kouhei Ohnishi

2007/02/01〜2012/03/31

YagamiCentre for Advanced Research on Logic and Sensibility

Professor, Graduate School of Human Relations

Shigeru Watanabe

2007/02/01〜2012/03/31

Mita

GSP Center (Center for Genome Super Power)

Professor, School of Medicine

Jun Kudo

2007/06/01〜2010/05/31

Shinanomachi

Center for Integrative Mathematical Sciences (CIMS)

Professor, Graduate School of Science and Technology

Yoshiaki Maeda

2007/05/01〜2011/03/31

Yagami

The Center for Civil Society with Comparative Perspective (CCC)

Professor, Graduate School of Law

Yoshiaki Kobayashi

2007/04/01〜2012/03/31

Mita

Co-Mobility Society Research Center

Professor, Faculty of Science and Technology

Hironao Kawashima

2007/07/01〜2010/03/31

Shin-Kawasaki

Market Quality Research Center at Keio University

Professor, Faculty of Economics

Eiji Hosoda

2007/09/01〜2012/03/31

Mita

Panel Data Research Center at Keio University

Professor, Faculty of Business and Commerce

Yoshio Higuchi

2007/09/01〜2012/03/31

Mita

Education and Research Center for Stem Cell Medicine

Professor, School of Medicine

Hideyuki Okano

2008/01/01〜2012/12/31

Shinanomachi

Keio Jean Monnet COE Centre for EU Studies

Professor, Faculty of Law

Katsuhiro Shoji

2007/09/01〜2012/08/31

MitaMedia Design Research Center

Professor, Graduate School of Media Design

Masahiko Inakage

2008/02/01〜2013/01/31

HiyoshiResearch Center for Life - Conjugated Chemistry

Professor, Faculty of Science and Technology

Koji Suzuki

2008/03/01〜2011/03/31

YagamiCenter of Governance for Civil Society

Professor, Faculty of Law

Yoshihisa Hagiwara

2008/03/01〜2010/02/28

MitaWork - Life Balance Research Center

Professor, Faculty of Nursing and Medical Care

Kaeko Yamashita

2008/07/01〜2011/03/31

Shonan Fujisawa

Center for Education and Research of Symbiotic, Safe and Secure System Design

Professor, Graduate School of System Design and Management Takashi Maeno

2008/07/01〜2013/03/31

Yagami/Hiyoshi

Career Development Center -Medical and Life Science-

Professor, School of Medicine

2008/07/01〜2013/03/31

Shinanomachi

Global Research Center for Science and Technology (SU)Professor, Graduate School of System Design and Management Taketoshi Hibiya

2008/07/01〜2010/03/31

HiyoshiCenter for Advanced Light-Wave Control Technologies

Professor, Faculty of Science and Technology

Fumihiko Kannari

2008/08/15〜2013/07/14

YagamiThe Twin Research Center for Behavioral Development

Professor, Faculty of Letters

Juko Ando

2008/09/01〜2010/03/31

Mita

Global Center for Public Space Information (SU)Professor, Graduate School of Media and GovernanceIkuyo Kaneko

2008/12/01〜2009/11/30

Shonan Fujisawa

Collaborative Innovation Center for Cutting-Edge Life Science Research

Professor, Faculty of Science and Technology

Hiroshi Yanagawa

2009/01/01〜2014/03/31

YagamiKeio-Med Open Access Facility

Professor, School of Medicine

Hideyuki Okano

2009/02/01〜2013/03/31

Shinanomachi

Spintronic Research Center

Professor, Faculty of Science and Technology

Kohei Ito

2009/03/01〜2012/03/31

Yagami

Nursing Best Practice Center (SU)Professor, Faculty of Nursing and Medical Care

Yuko Takeda

2009/03/01〜2011/02/28

Shinanomachi

Research Centre of Human Cognition (SU)Professor, Faculty of Letters

Shigeru Watanabe

2009/04/01〜2011/03/31

Mita

Global Center for Learning Scinence and Technology (SU)Professor, Graduate School of Media Design

Keiko Okawa

2009/04/01〜2011/03/31

Mita

Center for Energy and Environmentr (SU)Professor, Faculty of Business and Commerce

Yoko Wake

2009/04/30〜2010/03/31

Mita

Negotiation Research Center (SU)Professor, Faculty of Law

Jiro Tamura

2009/06/01〜2011/03/31

Mita

09 Keio Advanced Research Centers (KARC)

Toshio Suda

Office of Research Administration

http://www.ora.keio.ac.jp
E-mail: ora-honbu@adst.keio.ac.jp

Providing support for the enhancement of research activities

The Group of Offices of Research Administration, established in 1999, is made up of a head Office function and branch offices established on the Mita, Hiyoshi, Yagami,
Shinanomachi, and Shonan Fujisawa Campuses to provide effective research support to researchers affiliated with Keio University. Adding Shin-Kawasaki,
Tsuruoka, and Shiba-Kyoritsu Campuses as new members, these eight offices currently cooperate with the Head Office function to realize flexible and appropriate
administrative support on specific research projects inside and outside of Keio University, that are becoming increasingly diverse and complex.

1 Supporting the operation of industry-government-academia collaboration projects
In recent years, Keio University has been involved in the planning and acquisition of an increasing number of projects focusing on research and technology seeds sought out from a university-wide
perspective, and on the needs of external institutions that seeks innovative partnerships and proposals. The Offices of Research Administration on each campus have been working towards the developmentof these projects, with the Center for Research Promotion acting as a liaison, to support researchers and contribute to the implementation of high-quality research activities.
[Major research support services]•Gathering information on research grants, and providing relevant data to researchers•Acting as liaison with other related organizations inside and outside the university•Providing support in application processes and reporting procedures•Assisting in all aspects of project management(progress management, research expense management, negotiating and completing various types of contracts, including contracted research.)•Supporting the publication of research results and various PR activities

2 Supporting the operation of research projects conducted under the leadership of Campuses
Keio University is currently involved in a number of advanced research projects that are conducted under the initiative of the campuses on which these projects are conduted. Perssonel exchange andvarious forms of research are conducted in each field, through such organizations as the Keio Leading-edge Laboratory of Science and Technology (KLL) at the Yagami Campus; the Center for Integrated
Medical Research at the Shinanomachi Campus; the Keio Research Institute at SFC (Shonan Fujisawa Campus), the Shin-Kawasaki Frontier Research and Education Collaborative Square in
Kawasaki City, and the Institute for Advanced Biosciences in Tsuruoka City. The Offices of Research Administration on each campus play an important role in actively supporting research activities. Services
offered include: Studies of ideal research structures on each campus; mediation, negotiations, and completion of contracts related to joint research and contracted research; hiring procedures for researchstaff; PR and publishing activities(introductions of research and researchers, research results, etc.); management of research expenses and facilities; and operation of events.

3 Applications for and management of public research capital, and overseeing subsidy programs within the university
The Head Office of Research Administration, in collaboration with its branch offices , oversees all
aspects of large-scale competitive grants and private educational subsidies (special subsidies),
including the Global CEO Program, the Ministry of Education, Culture, Sports, Science andTechnology (MEXT) Subsidies for scientific research expenses, and the Special Coordination
Fund for the Promotion of Science and Technology. The Head Office also takes initiative in“compliance activities,” in which education is provided to researchers within the university
and to related administrative divisions regarding the appropriate use and management ofresearch expenses by research institutions, an area that has also increasingly become asubject of interest among the Japanese society over the past few years.
Educational activities include study meetings and the publication of manuals on the use of
research expenses.
Keio University has also established a number of original grant programs having internal funds andoperating expense budgets as financial resources, to enable researchers within the university toutilize these grants effectively in their own research activities. The Head Office of Research
Administration is also responsible for supervising the operation of these internal grant
programs. Furthermore, it plays a main part in responding to open calls from private sector
grant foundations and managing databases of information on researchers.

Examples of guidelines for administrative procedures created by the Office of Research
Administration Headquarters “Manual on the Management of Public/External ResearchFunds” and “Research Handbook”

Office of Research Administration 10

Research PICK UP
Research on Modern Politics in Korea andJapan-Korea Joint Research

Recipient of 2008 Fukuzawa Award

Masao Okonogi
Professor, Faculty of Law and Political Science
My research is related to the modern politics of the Korean Peninsula. This research consists ofthree main areas. The first area is Cold War history and the linking between regional politics andinternational politics, for example, in the formation of a divided system after the end of WWII and
during the Korean War. The second area is the domestic politics of South Korea and North
Korea after the entrenchment of the divided system. The third area of research is the conflict
between the two systems and reunification. I have taken great pains to think about Korean politics
from the perspective of leaders and citizens of both Koreas on the one hand and from the cold anddetached perspective of international politics on the other hand.
For example, two papers of mine that have recently been published relate to the first area of
research stated above, international political history of the early Cold War period. One paper isentitled “The Geopolitics of setting of the 38 Parallel—Military Operations against Japan andInternational Politics,” which is published in “Keio Political Science and International Politics,” acollection of papers from the Faculty of Law and Political Science in commemoration of the 150th
anniversary of Keio University. The second paper is entitled “The Korean Independence
Problem and the Trusteeship Framework—The Pursuit of ‘Joint Action’ by the Big Four,” which is
published in the latest issue (August) of “Keio Law Review.” One point that has now been
totally forgotten is that for 35 years until Japan’s defeat in WWII, the Korean Peninsula was a partof the Empire of Japan. Consequently, the liberation and decolonization, the division andoccupation by America and the Soviet Union, and the establishment of two nation states are allpart of the modern history of Japan.
Another paper relates to the third area of research stated above. The paper is entitled “A
Strange Coexistence with Nuclear Weapons—Regional Order in the Korean Peninsula,”
published in “East Asia Regional Order and Community Framework,” which is the final volume of
the Collected Papers on Japan-Korea Joint Research. This paper deals square on with theNorth Korean nuclear problem. In the development of nuclear weapons, each country has its own
motives. In the case of the failed state of North Korea, the most distinctive characteristic is how
closely its motive relates to the survival of the North Korean system. I argue that without the reformof or the end to the system, North Korea cannot be freed of nuclear weapons. Therefore, what isrequired is a prescription that is based on this reality.

However, I could not have received the 2008 Fukuzawa Award based solely on the researchmentioned above. As the award citation notes, “achievements in research on the politics of the
Korean Peninsula and Japan-Korea academic exchange,” I have been deeply involved in the
promotion of Japan-Korea joint research and exchange, especially in the fields of history and social
science. It is impossible to do research on the modern politics of the neighboring Korean
Peninsula without considering the realities of Japan and Korea and the state of theirrelationship. In that sense, regional researchers and international political scientists can take pridein their efforts. Even though researchers are not diplomats, I believe that the existence ofborderless networks of researchers can function as a buffer to soften conflict between
nations.
The Japan-Korea Joint Research Forum was launched in 1995 based the Murayama statement on
wartime history. This Forum with 210 researchers from Japan and South Korea is a joint large-scale
research project. Through joint research, I have been able to contribute to the formation of acommunity of Japan-Korea joint studies. In addition, even though I am only a social scientist, I havebeen deeply involved in the launch of the national Japan-Korea History Joint Research project,serving as a committee member in the first stage. Finally, I am serving as Japanese
representative of the “Japan-Korea New Era Joint Research Project” currently in progressunder an agreement between government leaders in Japan and South Korea.

The complete “Collected Papers
on Japan-Korea Joint Research”
in 21 volumes

Innovations in Early Life Course Transitions

An international collaborative research
project funded by the U.S. National Institutesof Health (NIH)

Noriko Tsuya
Professor, Faculty of Economics
This international collaborative research project seeks to account for the trends, patterns, andfactors associated with dramatic changes in Japanese family behaviors and attitudes, such as
marriage and childbearing, employment, and gender relations at home, based on data drawn fromlarge-scale national surveys. These behavioral and attitudinal changes are the primary forces
underlying Japan’s rapid aging and fertility declines to below-replacement levels. They arealso the main factors of the country’s population decline which is projected to accelerate
during the first half of the 21st century. These family changes have been brought about, at leastin part, by such macro social-structural changes as economic growth, industrialization, andurbanization that Japan has experienced after World War II, and similar socioeconomicchanges have occurred in almost all Western countries and many other industrialized
economies in Asia. With cultural heritage distinctively different from that of the West, Japan isthe first non-Western country to enter the post-industrial stage of industrial development. As such,the country provides an important case study, offering insights into the current experiences
and future prospects of family changes in other parts of Asia and beyond.
To empirically examine these behavioral and attitudinal changes in the Japanese family, the project
conducts two types of national survey in 2009: a follow-up of the 2000 national survey onfamily and economic conditions, and a cross-sectional survey based on a newly-drawn sample. The
former survey is a follow-up of the respondents of the National Survey of Family and Economic
Conditions (referred to as the NSFEC), conducted in 2000 as part of the “Asian Financial Crisis andMacro Economic Policy Response,” a grant-in-aid for COE research supported by Ministry of
Education, Culture, Sports, Science and Technology. The 2000 survey was based on a national twostage stratified probability sample of Japanese men and women aged 20-49 of all marital
statuses. The sampling units were randomly chosen based on the census tracts distributions of theJapanese population by gender, age, and place of residence. A total of 4,482 persons (2,102 men
and 2,380 women) were successfully surveyed. The follow-up under discussion is the firstattempt to trace all the respondents of the 2000 survey. Of all the 2000 survey respondents, 32
had either died or refused to participate, resulting in 4,450 persons as the target sample size forthe follow-up.

11 Research PICK UP

The field work for this second round of the NSFEC was conducted from May to June in 2009 by the
Shin Joho Center, the survey agency that carried out the field work of the NSFEC in 2000.
Although there were a considerable number of respondents whose contact addresses were
not updated or lost because a long time (9 years) had elapsed since the 2000 survey, we
successfully obtained 2,330 usable questionnaires.
This project also plans to conduct a new nationwide cross-sectional survey in October toNovember 2009. Like the 2000 survey, this new survey will also be a national, two-stage
stratified probability sample of Japanese men and women aged 20-49 of all marital statuses, basedon the population distributions by gender, age, and place of residence obtained from thecensus. Using the same questionnaire as the one used for the follow-up discussed above, we plan
to contact approximately 6,000 persons. While the objective of the follow-up survey was to collectinformation on changes in behavior and attitudes of same individual men and women, thisnew cross-sectional survey aims to obtain nationally representative data on work and family life
to examine the national trends in Japanese family behavior and attitudes through comparison withthe results from the 2000 survey. Using micro-data drawn from these surveys, we plan to
conduct various statistical analyses, based on both descriptive and multivariate models.

Questionnaire of the second round of the
National Survey of Family and Economic
Conditions

Research PICK UP
Environmental Activities in Shenyang andChengduFY2008
Keio University 150th Anniversary
Commemorative “Design the Future Fund”
Interdisciplinary Environment Project

Hikaru Sakuramoto
Professor, Faculty of Business and Commerce
In the developing countries of East Asia, environmental pollution and land degradation are
becoming worse. In Japan, the population is decreasing and the country is facing natural
blight. If conditions remain as they are, human survival will become threatened anddevelopment will not be sustainable. Based on a framework both international and national, thisresearch combines the principal activities of environmental businesses and citizens of Japan and
China. It aims to establish an environmental conservation and regional regeneration
framework through international policy coordination among communities. Long-term practice
centers have been implemented in Shenyang City, Liaoning Province in the Northeast interior andin Chengdu City, Sichuan Province. These centers have simultaneously carried out researchand conducted experiments.
The Project cooperates on a CDM (clean development mechanism) tree-planting project in
Shenyang and transplant experiments for the edible bamboo of pandas in Chengdu. Up to now
there have been a number of symposiums held in Tokyo, Beijing, Shenyang, and Chengdu.
Every effort is made to announce research progress and achievements.
Looking ahead, efforts will be made to strengthen human resource training in both Japan and in
the field, to expand the research organization, to create a framework of environmental policy
coordination, and to further advance demonstration experiments.
This Project was launched in 1985. Under the leadership of Professor Emeriti Yoshikazu
Hashimoto and Tatsuo Yamada, air pollution in East Asia was measured, a related network was
created, and an environmental research framework was discussed. In 1990, the Center for
Area Studies became home to the Research Center for the Chinese Environment (directed by Tatsuo
Yamada (1990-1993), by Tomoyuki Kojima (1994-2007), and by Hikaru Sakuramoto (from2008)). The Center conducts research related to air pollution, epidemiology, industry, legal
systems, political policy, and development. With a focus on the regions of Chengdu and
Shenyang, the Center has been working on general joint environmental research from its
launch to the present day.
Some years back, under a Keio University Special Grant-in-Aid for Innovative Collaborative
Research Projects (1996-1998, Professor Yoko Wake, Faculty of Business and Commerce), theProject implemented an “environmental model district” for achieving sustainable development in
Chinese cities and promoted its practice. Environmental model districts are still being
implemented today.
For the Mirai-Kaitaku Project—Asia’s Economic Development and Environmental Conservation

Linking the Body, Mind, and Language(1998-2001, Professor Kanji Yoshioka, Institute of Economic and Industrial Studies), the Project
participated in “Environmental Conservation of the Asian Region” under the “JSPS Research of
the Future Program.” This activity involved joint environmental research and theimplementation of specific programs. In addition, the Project has participated in multi-tiered
activities to improve the environment in Shenyang and Chengdu; for example, by introducing a biobriquette plant (to reduce SO2) and by reducing alkaline soil salinization. In Kangping County,
Shenyang City, the Project has participated in tree-planting, a 100-meter-wide belt stretching 100
kilometers called the “China-Japan Friendship Forest.” In Chengdu, the Project has been active intransplant experiments on the edible bamboo of pandas. And it has supported food aid andtuberculosis treatment in North Korea.
From 2002 to 2007, the Project participated in the “Policy Innovation Initiative: Human Security
Research in Japan and Asia” (a MEXT 21st Century COE Program) under the leadership ofProfessor Tomoyuki Kojima of the Faculty of Policy Management. Activities included policy
research and practice, commercialization proposals for small-scale CDM afforestation andreforestation and transplantation of edible bamboo for pandas.
The “Interdisciplinary Chinese Environment Project” from 2007 to 2009 has been selected by the
Keio University 150th Anniversary Commemorative “Design the Future Fund.” Activities
include visits to Shenyang each summer, the promotion of joint research based on JapaneseChinese research teams (including many undergraduate and graduate students from Keio).
Mixed teams of Japanese and Chinese students are formed to deepen understanding of joint
research and to work together on global environmental themes. Through these teams,
students experience the “spirit of practical science” and the meaning of international
exchange
The Project is currently making every effort tohave the “Japan-China Friendship Forest”
recognized as a small-scale CDM
afforestation project by the CDM Executive
Board at the United Nations. If approved, it
will be the first such project in Japan as set
forth in the Kyoto Protocol.
Tree-planting in Kangping County

FY2008
Keio University 150th Anniversary
Commemorative “Design the Future Fund”
Thinking about Voice Project

Chiaki Yokoyama
Professor of Faculty of Law and Director of Keio Research Center for the Liberal Arts
You know, when we communicate with each other, except in the written form of “language,” weuse our voice and body language without realizing it. In the same way, activities like acquiringknowledge, understanding, and communicating are all performed via the body. The “body”
means not only the physical body, but the mind and emotions that exist inside. The background torecent lively discussions on this kind of body might come from a sense of danger thatsurrounds people in the current age. That is, an air of crisis related to the body that feels
empty in the wave of technology and a mind, feelings, and insecurity that cannot be controlled
rationally.
Lately, a reflection of the current situation can been seen in various discussions about phrases suchas “theory of the body” and “mind-body” with their concepts having gone beyond
philosophical and aesthetic meanings. These discussions show that what is demanded in the realworld is education not limited to the classroom lecture.
Logical thinking capacity and sensitivity transform into true understanding and intelligencewhen they go hand-in-hand with the body. “Getting it” is a phrase that aptly expresses this kindof understanding. That is why diverse fields such as brain science and cognitive science, the artsand clinical psychology, and contemporary thought are all promoting research and education related
to the body. However, in reality there are very few places for mutual research exchange
between different academic fields.
The “Mind and Body Project,” which belongs to Core Research of the Keio Research Center for the
Liberal Arts, is a research program launched in response to these conditions. In this Project,researchers of different academic fields discuss various theories concerning the mind andbody. Findings from these discussions are verified through the research and practice ofexperimental classes. The “Thinking about Voice Project” covers the practical part of thisProject. This “Voice Project” has been active as a Design the Future Fund program since 2007.
One application is the experimental class “New Literature Education.” Using literature as it isdiscussed based on letters, this class is being developed to stimulate individual interpretations
through different modes of expression (e.g. recital, drama, dance, collage, music). Thenthrough re-creations to verbalize those interpretations, the class tries to build linkage between
language, society, and the mind and body. Thus far the class has discussed Lady Chatterley’s Loverby D.H. Lawrence, A Dream of John Ball by William Morris, and The Lives of Animals andDisgrace by J.M. Coetzee.
In addition to the original content, what distinguishes the class is the team of teachers and thestudents who enroll. Teachers of different specialties at Keio University work together withprofessionals (e.g. stage directors, modern dancers, actors, musicians, readers, athletes) toconstruct a new course that links with the outside of university. Great results were achieved in an
intensive class held for one week during the summer break with participation from students fromthe workforce enrolled in the Faculty of Correspondence Courses. Undergrads, correspondence
course students, and teachers gathered together as participants. This made the summer
intensive course an excellent opportunity for teachers to search for new literary interpretations andeducational methods.
Recently, the research of the “Body and Mind Project” and the practice of the “Voice Project” at
Keio Research Center for Liberal Arts have also received high praise from outside parties.
Looking ahead, the Center wants to see even more people participate in the Projects. Through the
feedback of participants, the Center aims to build new knowledge models that can be sent out tothe world.

2008 “New Literature
Education” experimental classResearch PICK UP 12

Mita Campus

Research Centers

For Inquiries:

Mita Campus
Pathways to the Future for the
Humanities, Social Sciences, andNatural Sciences: Centers forComprehensive Research and
Education

Mita Campus
2-15-45 Mita, Minato-ku, Tokyo,108-8345 Japan
TEL: +81-3-5427-1517

The Mita Campus is home to undergraduate departments (primarily for third-and fourth-year students), six graduate schools, and independent
research institutions. Here, we will introduce the recent status of activities at research facilities on the Mita Campus.

Research Institute for Digital Media and Content (DMC Institute) http://www.dmc.keio.ac.jp/en/
The Research Institute for Digital Media and Content (DMC Institute) seeks to create and circulate knowledge by pursuingresearch that consider digital contents from a variety of perspectives, including content design, media technology, intellectual property
management, and industry policy.
The Institute also makes efforts to transmit the results of research; for example, in March 2009, it held an international
symposium entitled “Designing The Global Creative Society.” It also pursues the potential of next-generation contents using highdefinition video through demonstrative experiments and joint research with companies and other universities.

At the symposium

Global Security Research Institute (G-SEC)

http://www.gsec.keio.ac.jp/index_e.html

The Global Security Research Institute (G-SEC) carries out research on the broad field of global security with an emphasis on “watching
and warning.” In other words, we constantly keep watch on problems in various fields and transmit necessary warnings. With thisconsciousness, we participate in industry-government-academia collaborations with an eye toward providing policy advice and creating
objective evaluations, while at the same time carrying out our research activities. Our goal is to contribute to the sustained
development of society. In FY2008, we expanded and deepened interfaces with society through our research. For
communicating common points in the Institute’s wide range of research areas, we 1) started “Watch and Warning” seminars, 2)sponsored the annual G-SEC conference, and 3) began publishing the G-SEC Newsletter. We also conducted numerous projects ina various fields, including Medicine and the Humanities / Social Sciences.
2nd Annual G-SEC Conference

Research Center for the Arts and Arts Administration

http://www.art-c.keio.ac.jp/en/

The Research Center for the Arts and Arts Administration at Keio University pursues researches in areas including the fine arts,
architecture, music, literature, theater, cinema, and dance, as well as their cultural appreciation in contemporary society from a holistic
and academic stance. In cooperation with experts, the Center develops and carries out domain-transcending activities such as
seminars, lectures, exhibitions, performances, workshops, case studies for art management, and construction of art archives.
Events in 2008 included a Butoh performance by Ko Murobushi entitled “quick silver / HIYOSHI version”; an exhibition entitled “TheUser’s Domain”; an exhibition of prints as part of Minato Ward contract business; and concerts, as well as a donated course by the
Recording Industry Association of Japan entitled “Creative Industry Research.” The Research Center held a report meeting for the
final year of Ministry of Education, Culture, Sports, Science and Technology (MEXT) ORC operations, and issued a printed
version of the report. The results of research are also published and disclosed in the Center’s Annual Report and in “ARTLET” and“BOOKLET.”
Publications: “Annual Report (2007/08)” No. 15; “ARTLET” No. 30 & 31; “BOOKLET” No. 17

Center for Japanese Studies http://www.ic.keio.ac.jp/nncenter/
The Center for Japanese Studies offers Japanese language and Japanese studies courses tointernational students. In addition, research on various topics related to second-language
education is carried out, in addition to the education and training of next generation Japanese
language teachers.
The Center for Japanese Studies promotes education in
Japanese language and culture. It provides Japaneseclasses for first-and second-year students enrolled at the
Hiyoshi campus and international students belonging to the
Graduate School of Science and Technology, as well as for 193
international students from 30 countries enrolled in theJapanese Language Program. In addition to Japanese
language classes, the Center also runs Japanese language
education courses to foster Japanese language instructors.
In the 2008 academic year, the Center published Nihongo to
Nihongo Kyoiku No. 37 (Japanese and Japanese Language
Education, March 31, 2009, ISSN 0286-5742).

13 Mita Campus“Japanese Language and Japanese
Language Education” Journal
No. 37“The User’s Domain”: Hanga woodblock prints, photos, and multiple works fromthe past and present (December 3-13, 2008)

The Keio Institute of East Asian Studies (KIEAS) http://www.kieas.keio.ac.jp/english/index.html
At the start of the 2007-08 year, the Keio Institute of East Asian Studies (KIEAS) established theCenter for Contemporary China Studies, and at the end of the 2008-2009 year, it established theCenter for Contemporary Korea Studies (Director: Masao Okonogi). An opening ceremony for the
new Center was held in February 2009 along with a commemorative symposium, welcoming many
participants from inside and outside of Keio University, including President Yuichiro Anzai.
KIEAS has also held numerous study meetings, including some by KIEAS Fellows, as well as joint
symposiums and workshops with Princeton University, University of Toronto, the North PacificRegion Advanced Research Center (Sapporo), the Asan Research Institute (Seoul), Korea
University (Seoul), and Chung-Aug
University (Seoul). It also held “KIEAS
Lectures” by 14 instructors on the themeof “Popular Culture and Festival Space in
East Asia.”

Commemorative symposium marking the
opening of the Center for Contemporary
Korea Studies (February 5, 2009)

Mita Campus
Fukuzawa Memorial Center for Modern Japanese Studies

http://www.fmc.keio.ac.jp/fmc/eng.html

In 2008, the Fukuzawa Memorial Center for Modern Japanese Studies opened a new course at the Hiyoshi campus, to add to thesix courses at the Mita campus. The Center also held a commemorative lecture in May and a commemorative workshop in
December to celebrate its 25th anniversary. As part of Keio University’s 150th anniversary events, the Center published the“The Keio Encyclopedia” before the anniversary celebration in November, and hosted the “Exhibition celebrating the 120th
anniversary of the birth of Shinzo Koizumi” (Library; old large meeting room) in May and handled the planning, display, andcatalog of the “Fukuzawa Yukichi: Living the Future” exhibit held from January to March at the Tokyo National Museum.
Publications: “Bulletin of Modern Japanese Studies” No. 25 (2008); “Newsletter of Fukuzawa Memorial Center for Modern
Japanese Studies, Keio University ” No. 9 & 10; “The final battle between Waseda and Keio; late autumn of 1943” (Kyoiku Hyoron
Sha Co.,Ltd.; Nov. 2008; jointly edited by the Waseda University Archives and the Fukuzawa Memorial Center for Modern
Japanese Studies, Keio University)

Teacher Training Center http://www.ttc.keio.ac.jp/
The Teacher Training Center, established in December 1982 as a university-wide organization for
training instructors, has turned out many outstanding teachers.
In 2008, using the “Teacher Logbook” developed through the Ministry of Education, Culture, Sports,
Science and Technology (MEXT) Teacher Training “Good Practice” Project, the Center
identified and worked to correct problems related to the Logbook’s functions. One of theresults of these efforts is enhanced management functions aimed at sharing information onacademic guidance. The Teacher Logbook can now be used by graduates, part-time instructors, andinstructors handling multiple courses.
Lecture meetings established in past years, including “Speaking with young teachers” and“Dialog with Society and others,” were also held in 2008.
In front-line education, the Teacher Training Center was responsible for “Tokyo 10-year
Training” in the summer, and for teachers’ university courses in Minato Ward.
The Teacher Training Center’s Annual Report (No. 19) was issued as a regular publication.

Shido Bunko, Institute of Oriental Classics

International Center

Lecture meeting commemorating the Center’s 25th anniversary (May 2008)

http://www.ic.keio.ac.jp/en/index.html

The International Center is at the core of Keio University's international activities. It is
responsible for sending numerous students and scholars abroad every year, as well as
welcoming those coming to the University. The Center provides support to international
students on both academic and lifestyle matters, and is also in charge of exchange programs andoverseas short-term research programs. For that purpose, it holds overseas study fairs andinformation sessions on studying abroad in general, and also provides information on
exchange programs. There are also International Studies and Japanese Studies courses inwhich both overseas and Japanese students can study subjects such as the culture, history, politics,
and economics of Japan and other countries in English, to promote mutual understanding ofdifferent cultures.
In addition to regular courses, the International Center provides support for international
symposiums and various other events. Among the events held during FY2008 was a summer
program at the Mita Campus in collaboration with Bocconi University in Milan, Italy.

http://www.sido.keio.ac.jp/

The Institute of Oriental Classics or “Shido Bunko” is an affiliate institute with a Director, six full-time instructors, and four part-time
instructors (two from Keio University and two from outside the University). Its mission is to conduct bibliographical research related
to Japanese and Chinese literature. During the FY2008, it welcomed Chen Zhenghong as a visiting professor from the Classics
Research Laboratory at Fudan University in Shanghai, China. Prof. Chen gave a presentation at the 22nd Shido Bunko Lecture Meeting
entitled “The Significance of Chinese Texts in Vietnam as part of Publishing Culture in East Asia: Looking at books stored in the Keio
University Library and the Tohoku University Library.”
Publications in 2008 included “Bulletin of the Shido Bunko Institute” No. 43 (February 28, 2009) and “Kokin-shu Chushakusho Eiinsokan
1, 2, and 5-8” (Bensey Publishing Co.; November-December 2008; editing supervised by Shido Bunko).
Small exhibition at the 22nd Shido Bunko Lecture Meeting

Keio Economic Observatory

http://www.sanken.keio.ac.jp/index_e.html

The Keio Economic Observatory (KEO) was set up as an affiliated institute in 1959, as part of the commemoration of the 100th
anniversary of the founding of Keio University. Since then, it has conducted academic researches in the three fields of
Economics, Law, and Behavioral Science. The membership consists of full-time members of the Institute, members from related
Faculties, and co-researchers from Japan and overseas. Projects include the construction and analysis of databases on subjects suchas input-output analysis, the environment, and Flow of Funds analysis; the oral history of industrial relations; and a proposal for
applying the Antitrust Law to public utilities. The Institute is also conducting empirical research into various projects such as anenvironmental assessment of solar powered satellites (SPS) and an aforestation clean development mechanism (A/R CDM)
project. From FY2007, the Institute initiated a project relating to productivity in Asian countries and held an international
symposium relating to the measurement of productivity.
Publications this year included the Library of Keio University Sangyo Kenkyujo and Keio Economic Observatory Discussion
Papers.

Special lecture by Professor Dale W. Jorgenson (January 15, 2009)

Institute for Media and Communications Research http://www.mediacom.keio.ac.jp/english/about.html
This year, the Institute for Media and Communications Research conducted six research projects using research funds, special
contributions, and educational promotion capital from other sources. The results of research were published in a journal outline andan independent volume.
Published research included:
Keio Media and Communications Research No. 59 (March 2009)
Keio Communication Review No. 31 (March 2009)
Video Content Industry and Film Policy; Ed.: Minoru Sugaya, Kiyoshi Nakamura, Takashi Uchiyama; Maruzen Co., Ltd. (Jan. 2009)
Cultural Migrants: Young Japanese and Transnational Media
Yuko Fujita; Shin-Yo-Sha (Sept. 2008)
Partial list of research results

Institute of Cultural and Linguistic Studies

http://www.icl.keio.ac.jp/

The Institute of Cultural and Linguistic Studies has full-time staff and conducts basic researches on subjects such as the various languages, cultures, and philosophies around the world, and on linguistics
and linguistic theory. The Institute promotes a wide range of research projects together with scholars both from within Keio and outside. In FY2008, it issued REPORT of The Keio Institute of Culturaland Linguistic Studies No. 40 (March 2009) .
The Institute also invites eminent scholars from Japan and overseas to a wide range of international conferences, symposia and lecture meetings, such as the Tokyo Conference on
Psycholinguistics (TCP), linguistics colloquia (three times a year), an Islam lecture meeting, and two courses that are open to the public. The TCP report was published as a collection of research papers
in English. In addition, the Institute has set up special courses relating to languages that are not offered by any academic department (23 courses on 11 languages).
Publications: REPORT of The Keio Institute of Cultural and Linguistic Studies No. 40
Mita Campus 14

Research Centers

Hiyoshi Campus

For Inquiries:

Hiyoshi Campus
Research and Education Centers
Open to the Neighborhood,
Aiming for Collaboration withSociety and the Local Community

Hiyoshi Campus
4-1-1 Hiyoshi, Kohoku-ku,
Yokohama-shi,
Kanagawa, 223-8521 Japan
TEL: +81-45-566-1000

The Hiyoshi Campus houses seven faculties (Letters, Economics, Law, Business and Commerce, Science and Technology, Medicine, andPharmacy) for first and second year students; three graduate schools (Keio Business School (KBS), System Design and Management (SDM), and KeioMedia Design (KMD)); and six research institutes.

Graduate School of System Design and Management (SDM) http://www.sdm.keio.ac.jp/
The Graduate School of System Design and Management conducted lectures endowed by the Norinchukin Bank and the Nihon Keizai Shimbun and held thesymposium “The Challenge of Living with the Environment through Next-Generation Systems.” Externally-funded projects totaled 23 of which three were basedon public funds, 15 on private funds, three on grants-in-aid for scientific research (Kakenhi), one on Kakenhi contribution arrangement, and one on a NEDO
contribution. These projects conducted research on advanced manufacturing system support, robust design for next-generation systems, safe systemmanagement, visualization in immersive dome environment, and ground-to-train communication system using free-space optics technology. SDM cooperates with
the Graduate School of Science and Technology on the Global COE Program “Center for Education and Research of Symbiotic, Safe and Secure System
Design.” The Center has produced 35 original papers, delivered 76 oral presentations at academic meetings, and received a total of 20 copyrights, patents, andawards.
Train communication experimentusing optical space waves

Graduate School of Media Design (KMD)

http://www.kmd.keio.ac.jp/

The Graduate School of Media Design (KMD) was established in April 2008 to advance integrated research and education in the fields
of digital media, content, and design. With a focus on creativity, KMD is an advanced interdisciplinary education program open to
the world for the development of "media innovators" who can become leaders on the international stage. With a home at the Kyoseikan on the Hiyoshi Campus, KMD’S 13 faculty members and two research members engage in research and education activities with91 students, including 19 exchange students.
In KMD’s first year, several research achievements by newly admitted students were selected by top-level international
conferences such as those hosted by ACM SIGGRAPH and others. In March, KMD hosted the student-led video event “Future Motion
2009.” Students and faculty are working together to positively develop research and education activities at KMD.
Future Motion 2009

Graduate School of Business Administration (KBS) http://www.kbs.keio.ac.jp/

Research and Education Center for Natural Sciences http://www.sci.keio.ac.jp/

KBS held a symposium on “Restoring the International Competitiveness of Japanese Firms—
Seeking a New Way of Corporate Management under a Financial Crisis.” Under the themes ofsolving the problem of cutthroat competition and strengthening overseas investment, the aim of
the symposium was to search for measures to recover the international competitiveness ofJapanese companies from the viewpoint of business structural reform.
Together with researchers from Tsinghua
University (China) and KAIST (South Korea),
KBS also held a workshop at the Kyosei-kan
on business issues, prospects, and the way ofmanagement in Asia. With participants fromthe top business schools in China, Korea, andJapan, this workshop marked the inaugural
meeting on joint research. A second meeting isplanned to be held in Beijing, China.

The Research and Education Center for Natural Sciences was launched on the Hiyoshi Campus on
April 1, 2009. The Center advances research and education activities in natural sciences in a broad
sense. The Center plans to promote
projects of various contents and scales,from cutting-edge academic research toresearch and education activities incooperation with combined schools,
irrespective of the faculty or the area ofspecialty. On November 20, 2009, theCenter will host a symposium at the
Raiosha facility.
Overview of starfish larva’s nervous system (left)
and adult starfish (right)

East Asia business school workshop

A Place to Interact and Work Together with Society on “Knowledge”
Hiyoshi Campus has been steadily unfurling research activities in a wide range of disciplines—including the humanities, the social
sciences, and the natural sciences—with the aim of introducing its achievements to parties within and without theuniversity and returning the fruits of those achievements back to society. To fulfill that aim, Hiyoshi Campus has held the Hiyoshi
Research Portfolio (HRP) since 2005. In 2008, Hiyoshi Campus held a poster panel exhibit of research achievements, various
symposiums, lecture meetings, and special exhibitions to commemorate the 150th anniversary of Keio University.
http://campus.hc.keio.ac.jp/ora/HRP/
Raiosha meeting place

15 Hiyoshi Campus

Hiyoshi Campus
The Keio Research Center for the Liberal Arts http://www.hc.keio.ac.jp/lib-arts/en/index.html
The Keio Research Center for the Liberal Arts was founded in July 2002 to search for the ideal systems that liberal arts
education should adopt through multifaceted investigations and researches conducted in Japan and overseas, planning andmaking proposals for specific programs, and at the same time validating the effectiveness of those proposals throughexperiments.
The approximately 200 members, from a wide range of educational organizations from integrated high schools to various
campuses and institutes of the univeristy, have been actively conducting research.
In FY2008, the Center promoted “Core Research” in two areas (“Keio University Educational Curriculum Research” and “Body and
Mind Project”), “Specialized Research” centered on "Hyper Representation Digital Research" under the “Academic Frontier”
category of the “Promotional Project for Advancement of Academic Research at Private Universities, and “Individual Research” that
supports the researches by individual members of the Center. The Center has been establishing partnerships with researchfacilities and scholars within and without Keio University to expand research network in liberal arts. It has also offeredexperimental courses, lectures, and seminars, together with publishing and validating research results both in print anddatabases.

Academic Skills Presentation Competition

Periodicals issued by the Center include: Annual Research Reports, Newsletters, Symposium Reports, CLA Archives, Activity Reports, and Liberal Arts Research Center Library.

Keio Research Center for Foreign Language Education http://www.flang.keio.ac.jp/
The Keio Research Center for Foreign Language Education was founded in October 2003. One of the Center's primary missions is toconsider foreign language education across all Keio affiliated schools. The Center has a total of approximately 100 members covering
the range from elementary school to graduate school, and is driving forward with its research activities.
The Center was selected as a center for the Academic Frontier Program for Promoting Research Excellence at Private
Universities for its "Action Oriented Plurilingual Language Learning (AOP) Project." This project is expanding research that gains acomprehensive understanding of all study stages from primary school to graduate school and increases the consistency of
foreign language study, centered on English-language education, and also focuses on the challenge of enhancing plurilingual andpluricultural capabilities in communications. (http://www.aop.flang.keio.ac.jp/)
Periodicals: Journal of Foreign Language Education, Annual Research Report, and Keio Research Center for Foreign Language
Education Symposium.

Health Center

Foreign Language Lounge

http://www.hcc.keio.ac.jp/

The field of Health Center's research is divided into physical and mental health. The Center is conducting researches onhypertension, diabetes, metabolic syndrome, obesity and other lifestyle-related diseases, as well as anorexia nervosa, cardiac
diseases, liver diseases, infectious diseases, respiratory diseases, and mental disorders.
The Center is collaborating internationally on research into hypertension, strokes, and metabolic syndrome, and has published papers
on that research.
The Center published 47 papers written in English between 1972 and 1994, and 214 papers between 1995 and 2008. Members of
the Center have also made presentations at international conferences such as those held by the International Society ofHypertension and the American Diabetes Association.
The Center publishes the Bulletin of Keio University Health Center and the Annual Report of Keio University Health Center once a
year.

Sports Medicine Research Center

http://www.hc.keio.ac.jp/sports/

The Sports Medicine Research Center covers a broad range of activities. In addition to improving the competitive performance andstrength of athletes, the Center is active in maintaining and enhancing the health of the general public and in preventing and treating
diseases (e.g. obesity, lifestyle-related disease).
From FY2007, the Center has held open lectures on “Sports and Health” in partnership with the Graduate School of HealthManagement for the purpose of presenting evidence-based information to the local community in an easy-to-understand format. In
FY2008, the Center simultaneously held an open lecture on “The Secret to Maintaining Sports Activity for Health” and a “Nordic
Walking” event. The Center also worked with the Keio University Athletic League on the “Sakura Sports Festival,” a joint project withthe local community. In the area of research, a three-year intervention study is underway on improving the lives of people
suffering from metabolic syndrome. With other research as well, the Center reports its results at local and international
conferences on sports and lifestyle-related disease.

Institute of Physical Education

Health Center (Hiyoshi)

Exercise ECG

http://www.hc.keio.ac.jp/ipe/

Since its foundation in 1961, the Institute of Physical Education has promoted the importance of health and sports to Keio
University students and teaching staff, and also local residents, through physical education courses within the university,
symposiums, and open courses. At the same time, the Institute has implemented a wide range of research related to physicaleducation, health, and sports. In June 2008, the New Building Completion Commemorative Forum of the Institute of Physical Education
was held under the Keio University 150th Commemorative Project. Symposium I emphasized research while Symposium IIemphasized education. The topic of Symposium I was “Thinking about the Future of Health and Sports Science at Todai, Kyodai,
Waseda, and Keio.” Representatives from The University of Tokyo, Kyoto University, Waseda University, and Keio University
exchanged information on the future direction of sports science.
Periodicals: Bulletin of the Institute of Physical Education and Activity Report of the Institute of Physical Education.

New Building Completion Commemorative Forum

Hiyoshi Campus 16

Yagami Campus

Research Centers

For Inquiries:

Yagami Campus
Aspiring and Working for the
Next Frontiers of Science andTechnology

Secretariat of the KLL
c/o Office of Research Administration, Yagami Campus
TEL: +81-45-566-1794
http://www.kll.keio.ac.jp/
E-mail: staff@kll.keio.ac.jp
KLL Liaison Office
TEL: +81-45-566-1438
http://www.kll.keio.ac.jp/liaison/index.html
E-mail: liaison@educ.cc.keio.ac.jp

Faculty/Graduate School of Science and Technology
The Faculty and Graduate School of Science and Technology are located at the Yagami Campus, where
research and education centered on scientific and technological fields are conducted.
Approximately 1,800 Master’s and Doctoral students in the Graduate school are pursuing their studies andresearch, together with third and fourth-year undergraduate students. In response to the incredible
advances and diversity of science and technology today, the Graduate School of Science and Technology
established three schools in the year 2000 that deliberately promote a interdisciplinary approach: the School of
Fundamental Science and Technology, the School of Integrated Design Engineering, and the School of
Science for Open and Environmental Systems.
In accordance with the principle of pursuing "emerging" themes, work on the campus will continue to be more open and multifaceted, in the form of joint
studies into various issues in as-yet unknown interdisciplinary areas that go beyond conventional fields of specialization. Our mission is to foster humanresources, as members of society who not only study the leading edge, but also open it up for themselves and become leaders of society.
Specifically, we are seeking to achieve these ends by promoting joint Industry, Government, and Academia Projects through the Keio Leading-edge
Laboratory of Science and Technology (KLL). http://www2.st.keio.ac.jp/english/

The Keio Leading-edge Laboratory of Science andTechnology (KLL) was established within the Graduate
School of Science and Technology in 2000 as a center for
leading academic research and new business creation,and to act as a stage for collaboration between industry,
government, and academia. As a point of contact for
research partnerships, the KLL promotes dynamic research
partnerships that draw on the originality andinternationality of Keio University, as well as its strength asa multidiscipline university. To that end, the KLL
coordinates joint research and commissioned research
projects and also provides detailed support relating toresearch agreements, and provides a forum for
networking with the industrial world in order to promote thereturn of research achievements to society.
The KLL also has an important mission and is positioned tocreate new research fields and foster outstanding
scholars, and so it works to encourage nascent research andbearers of the future. By providing KLL Specified Research
Projects intended for young or newly-appointed scholars
and research grant programs intended for doctoral
program students, the KLL provides a system of support
from both the research funding and environmental
viewpoints that is both proactive and carefully planned.

Research Coordination (Liaison Function)
The KLL acts as a point of contact between Keio University and groups outside of Keio
University such as industrial circles, promoting cooperation for research work in the prepatent, or
nascent, stage. By introducing the research activities of the Yagami Campus from various
viewpoints and responding flexibly to individual concerns, the KLL creates an interactive flow
between corporations and university research activities. Utilization of these dynamics enables the
KLL to coordinate optimal joint and commissioned research projects, whether within Japan orinternationally.

Features of Corporate/University Partnerships under KLL

Corporation

Final product or business

Patenting of achievements
Keio University Intellectual
Property Center

Applied research

Needs•Commissioned research•Joint research•Feedback and informationexchange•Technological guidance

Basic research

17 Yagami Campus

Seeds

▲

Keio Leading-edge Laboratory of Scienceand Technology (KLL)

Keio University
Graduate School of Scienceand Technology

Yagami Campus

To Play a Leading Role in Society

KLL Specified Research Projects Selected in FY2008 (Examples)

Fostering of nascent research and researchers
Every year, the KLL calls for "KLL Specified Research Projects" with theobjective of focusing on the development of nascent research fields that areconsidered to be important to society in the future, to create new research
fields and encourage the fostering of leaders in those fields.
The KLL also provides research grants to master’s and doctoral program
students, with the objective of fostering outstanding scholars in the fields ofscience and technology. In FY2008, the KLL extended grants of ¥300,000 toeach of 135 students in doctoral programs. It has also set up a system to assist
with partial travel expenses to students in master's programs, to enable them topresent their research at international academic conferences.

“A Research on Closed-Loop Supply Chain Management System”
Cao De-bi, Professor, School of Science for Open and Environmental Systems“Development of Cryogenic Micromachining Technique of the
Substrate Material for Microfluidic chip”
Yasuhiro Kakinuma, Assistant Professor, School of Integrated Design Engineering“Studies on the mechanism of ER stress-induced cellular response by
Chemical-system-biology approach”
Etsu Tashiro, Assistant Professor, School of Fundamental Science and Technology

Promotion of Joint Industry, Government, and Academia Projects
Through its liaison and other activities, the KLL provides research contract
support for suitably matched research themes as well as publicly proposed
issues that are accepted. The first consideration is how contracts would
facilitate the pursuit of research in an environment that is advantageous to boththe sponsoring companies and researchers. Going beyond routine
contractual matters, the KLL seeks to provide a comprehensive collaborative
research-related service including consultation regarding research space.

funding after such adoption, in response to research funding management andaccount audit.

Commissioned Research Projects (Examples)“A Study on Inter-chip Communication by Inductive-coupling Channel”
Japan Science and Technology Agency
Tadahiro Kuroda, Professor, School of Integrated Design Engineering

The KLL also actively promotes the adoption of public funding by gathering andpublicizing information on funding sources such as public subscriptions forcompetitive research funds from government and research grants frompublic utility foundations, and not just private funding. It also provides, with asupport of Office of Research Administration at Yagami, an environment inwhich researchers can be reassured about the utilization of research

▲

Cases

Numbers of Commissioned Research Projects and Other Cases Received(FY2002 - FY2008)

350
84

300

91

77

250

57

57

52

139

127

118

132

121

114
178

64

130

119

72

143

89

0
2002

2003
Government organizations andpublic-service corporations

2004“The Photon Frontier Network Program (Advanced Light-Wave
Control Technologies)”
Ministry of Education, Culture, Sports, Science and Technology

104

100
50

Naoaki Yamanaka, Professor, School of Science for Open and Environmental Systems

Fumihiko Kannari, Professor, School of Integrated Design Engineering

78

200
150

“Active Optical Access System with Silicon Photonic Integrated
Circuit Project”
National Institute of Information and Communications Technology

2005
Private corporations(specified contributions)

2006

2007

2008

“Research and Development of Polymer Electrolyte Fuel Cell Systems
Research and Development of Polymer Electrolyte Fuel Cell - Multipoints and Real-time Measurements of Water-content in PEM andCurrent through the use of small NMR Coils”
New Energy and Industrial Technology Development Organization
Kuniyasu Ogawa, Associate Professor, School of Science for Open and Environmental

Private corporations(commissioned research, etc.)

Systems▼
Returning of Research Achievements to Society
The KLL holds the Science and Technology Exhibition (Keio Techno-Mall) every December to inform the public about the Faculty and Graduate School of Scienceand Technology's research achievements and to attract corporate interest in collaborative projects. The exhibition emphasizes demonstrations and hands-on exhibitsthat visitors can actually see and touch.
Dedicated to the theme "Innovative frontiers dreams" the 9th exhibit in 2008 drew over 1,200 visitors. The exhibition featured 70 booths covering a wide rangeof research achievements, while hosting roundtable discussions on three themes—Ecological Technology, Inter-faculty Collaboration with Medical andScience & Technology, and New Technologies for
Fluid Dynamics and Chemical Reactions—andorganizing 14 seminars on different collaborativetechnologies. Commemorating the 10th anniversary of
the KLL, the 2009 exhibition, whose theme is"Shaping the Future with Science", is scheduled for
December 11 in Halls B7 and B5 of the Tokyo
International Forum in Yurakucho.
Scene at the Keio Techno-Mall 2008 exhibition

Demonstration at a booth at the Keio Techno-Mall 2008

Yagami Campus 18

Shinanomachi Campus

Research Centers

Shinanomachi Campus
Center for Translational Research~ from Bench to Bed ~For Inquiries:
Office of Research Administration at Shinanomachi
TEL: +81-3-5363-3879
http://www.med.keio.ac.jp/research/
E-mail:ras-shinanomachi@adst.keio.ac.jp
Keio University Medical Science Fund
TEL: +81-3-5363-3609
http://www.ms-fund.keio.ac.jp/index_jp.htm
E-mail:k-msf@adst.keio.ac.jp

The Shinanomachi campus brings together medical education, research, and care facilities, such as the School of Medicine (second-year to sixth-year
students), the Faculty of Nursing and Medical Care (third-year students), the Graduate School of Medicine, and the University Hospital.
The Research Park at the Center for Integrated Medical Research houses research units involving other faculties, universities and research
institutions, as well as business enterprises. It promotes strategic interdisciplinary research in the field of life sciences that extends beyond
conventional paradigms of research areas and organizations.
The Center for Clinical Research is in the Building for Clinical Research completed in 2008 to provide support for clinical trials and translational research.
http://www.sc.keio.ac.jp/

School of Medicine and Graduate School of Medicine http://www.med.keio.ac.jp/
The School of Medicine was established in 1917, with a world renowned bacteriologist ShibasaburoKitasato as the first Dean. To overcome the various problems caused by each department working
independently, Professor Kitasato instituted a large-class system, which emphasized cooperation
between basic and clinical medicine, and the practice of medicine as a practical science. In an effort to carryout the medical education that Professor Kitasato had envisioned, the doctoral program of the Graduate
School of Medicine was launched in 1956 and the master's course in 1994 to foster trustworthy medical
personnel who combine knowledge, skills, and a well-rounded personality.
Portraits of Yukichi Fukuzawa and Shibasaburo Kitasato

Center for Integrated Medical Research http://www.cimr.med.keio.ac.jp/
The Center for Integrated Medical Research aims to develop interdisciplinary research of medical
science, science and technology, social science, and environment and information engineering. It also strives
to make contributions to society through their research achievements.
Promoting expansion of diverse cutting-edge research in life sciences, the Research Park, which acts as theCenter’s strategic research division, leases space (limited, in principle, to 3 years) to research units
formed of researchers from various disciplines and institutions who share common objectives.
The Center’s "Type J" system provides opportunities for young researchers to be principal investigators todevelop groundbreaking research under favorable conditions. The Center also provides space for large-scale
projects conducted with research funds from both inside and outside the university, and it functions as theresearch center for those projects.

Institute of Integrated Medical ResearchCenter for Clinical Research (CCR) http://www.ccr.med.keio.ac.jp/
The Center for Clinical Research is where the School of Medicine and the Keio University Hospital
combine to conduct clinical trials and clinical/translational research (clinical research) that contribute to thedevelopment of innovative, cutting-edge medical treatments and revolutionary drugs. The Center provides
support for research implementation, starting with consultation at the planning stage and following
through from subject recruitment to bio-statistical analysis. It also provides educational research
programs for medical personnel.
Beyond clinical research by individual researchers or clinical departments, the Center for ClinicalResearch promotes systematic clinical research, implementation of clinical trials, and the establishment of
support systems backed by the School of Medicine, the University Hospital, and affiliated institutions.

Building for Clinical Research

Keio University Hospital http://www.hosp.med.keio.ac.jp/
The Keio University Hospital has 29 clinical departments, 5 central treatment groups, and 7 crosssectional cluster divisions of the School of Medicine and the hospital. The hospital receives an average of
4,000 outpatient visits per day and has about 920 inpatients. It accepts over 20,000 emergency patients andhandles over 7,000 general-anesthetic surgeries per year. The hospital provides advanced medical
treatments as a tertiary hospital and promotes regional medical care through staff exchanges andmedical collaborations with 105 hospitals all over Japan.
Keio University Hospital

19 Shinanomachi Campus

Shinanomachi Campus
Endowed Laboratories in the School of Medicine
and the Graduate School of Medicine

Research Funds at Shinomachi Campus

Joint Research Projects
Novartis Pharma K. K.
Exploratory research for new therapeutic targets in cardiorespiratory
medicine

Department of Advanced Cardiac Therapeutics (Suntory)

University Funds

Nisshin-Kyorin Asahi Medical Clinical Research Center ofInflammatory Bowel Disease

Institute of Medicial Moleclar Design Inc
Renoprotective Drug Development targeted to NFKB

Bridgestone Laboratory of Developmental and Regenerative
Neuroscience

Joint Research

Johnson & Johnson Ocular Surface Visual Optics

Noevir Co., Ltd.
Noevir-Keio Translational Research Laboratory: Dept. of Cell Biology
and Neuroscience

Department of Musculoskeletal Reconstruction andRegeneration Surgery

Commissioned
Research

Subsidies

Ono Pharmaceutical Co., Ltd.
Pathology of acute lung damage and clarification of molecular
structure of convergence and repair capabilities

Inaida Endowed Department of Anti-Aging Ophthalmology

Kowa Company, Ltd.
Clarification of the physiological role of oxidant stresses in dry-eye

Inaida Laboratory for Anti-Aging Ophthalmology
Inaida Research Center for Anti-Aging Medicine in HepatoGastroenterology

Specified Donation(Research)

Endocrinology and Anti-aging Medicine

Grants (Research)Center for Gastroenterology and Clinical Oncology Research(CGCOR)

Thousand Yen

0,167,494

Novartis Pharma Program for Cerebrovascular Disease
Prevention Medicine

Subsidies

2,855,950

Department of Cell Biology and Neuroscience

Grants (Research)Specified Donation (Research)

Toshiba Medical Systems Corporation
Non-invasive radiotherapy and diagnostic system for cancer
management

Department of Advanced Therapy for Spine and Spinal Cord
Disorders

67,0001,902,535

Commissioned Research

1,873,712

Schering-Plough Center for the Study of Chronic Liver
Diseases

Joint Research

0,0894,908

Department of Anti-Aging Musculoskeletal Research

Total

7,761,599

Molecular Metabolism and System Medicine

GE Yokogawa Medical Systems Ltd.
Improvement of individualized medicine by use of multi-dimensional
non-invasive imaging with CT/MR
Otsuka Pharmaceutical Co., Ltd.
Keio Stroke Research Center: The Comprehensive Research Projects
for Brain Ischemia
LinkGenomics, Inc
Development program from diseases caused by epithelialtomesenchymal transition (EMT)

Daiichi Sankyo Cardiovascular Inflammation
Tokyo Electric Power Company Advanced Medical Sciencesand Environmental Preventative Medicine

Faculty of Environment
and Information Studies,
Faculty of Nursing andMedical Care,
Faculty of Pharmacy,etc.

Mitsubishi Tanabe Pharma Corporation
Creation and functional evaluation of artificial blood platelets bynanoparticles supported by molecule recognition sites
Daiichi Sankyo Co., Ltd.
Keio-Daiichi Sankyo Project on Genetics of Thrombosis

Novartis Phama Program for Clinical Therapeutics ofHematologic Malignancy

University Funds

Shionogi & Co., Ltd.
Clarification of molecular structures in renal aging and cardiorenal
linkages, and clinical application to cardiovascular accident outbreakcontrol of chronic kidney disease

Ajinomoto Co., Inc.
The pharmacological action of amino acids in Crohn's disease andanalysis of changes in amino acid metabolic balance underpathology

Integrated Renal Replacement Therapy and Translational
Medicine

Kyowa Hakko Kirin Co., Ltd.
Analysis of undifferentiated sustainability and self-renewal
mechanism of haemoatopoietic stem cells

Frontier Medicine on Metabolic Syndrome

Thirteen other joint projects

Shinanomachi Campus
Graduate School of Medicine/School of Medicine

Faculty andGraduate School of
Science andTechnology
SeminarCenter for Integrated
Medical Research

Research Park
Research Park

From Bench to Bed
Tsuruoka Town
CampusCenter for Translational ResearchShin-Kawasaki
Town Campus

Keio University Hospital
University Hospital

Keio University Medical Science Fund
In Fall 1994, Dr. Mitsunada Sakaguchi, a 1940 alumnus of the School of Medicine,
donated five billion yen to Keio University, with the expressed desire that it be used toencourage medical research and its creative progress at Keio and to promoteworldwide medical advances. To fully reflect Dr. Sakaguchi's commitment, Keiolaunched the Keio University Medical Science Fund on April 1, 1995. Dr. Sakaguchi madean additional donation of two billion yen in July 1999, bringing the fund to a total of 7
billion yen.

Keio Medical Science Prize
Keio Medical Science Prize honors theoutstanding and creative achievements ofresearchers in the field of the medical and life
sciences, in particular those contributing toscientific developments in medicine. The prize isawarded irrespective of nationality. Laureatesreceive a certificate of merit, medal and amonetary award of 20 million yen. The award
ceremony, commemorative lectures given by the laureates and commemorative
symposium are held at Keio University.
Shinanomachi Campus

20

Shonan Fujisawa Campus

Research Centers

Shonan Fujisawa Campus (SFC)
Contributing to Social
Development with Cutting-edge
Research Based on
Interdisciplinary CooperationSFC
The Shonan Fujisawa Campus (SFC) wasestablished in 1990 with the aim of creating a site forresearch and education based on completely new
concepts adapted to the changing times. In
addition to the three faculties of Policy
Management, Environment and Information
Studies, and Nursing and Medical Care, it also has
the Graduate School of Media and Governance,
which aims to foster highly professional people
who will play a major role in 21st Century society,and the Graduate School of Health Management,
which further expands and develops the concept of
the Faculty of Nursing and Medical Care byproviding a program that enables graduates ofboth the sciences and humanities to tackle thebroad subject of "Health". Situated on a futuristic
330,000 square meter campus, SFC seeks tomaintain a balance between advanced technology
and a rich, natural environment. Research projects
serve as the core of a participatory curriculum
which instills students with specialized knowledge
and practical skills.
http://www.sfc.keio.ac.jp/en/top.html

Keio Research Institute at SFC
The Keio Research Institute at SFC is an affiliate
institute of the three SFC faculties and the
Graduate School of Media and Governance, which
promotes research activities at SFC.
As a leading center of cutting-edge research in the
21st century, the Institute works to further
enhance society's advancement by performing
ground-breaking
research
basedoninterdisciplinary cooperation and by nurturing a
two-way partnership between educational andresearch activities at the campus. This includes all
related activities with industry, government, andacademia both within Japan and overseas.
Specific measures to achieve these objectives
include the promotion of joint research projects
with other organizations and the support ofventure incubation efforts. A feature of the Keio
Research Institute at SFC is the SFC ResearchConsortium, which encourages university-led
collaborative research by multiple organizations.
There are currently 12 such projects under way (as ofJune 1, 2009).
The Institute has also been commissioned to
execute about 190 research projects per year,
funded by approximately ¥1.5 billion fromgovernment agencies, local governments, andprivate companies (FY2008 data).
This research is performed not just by researchers
within SFC, but also by approximately 400 visiting
researchers from outside.
The Institute is committed to presenting the fruits of
its research widely to the public so that the results of
its efforts can be returned to society.
http://www.kri.sfc.keio.ac.jp/en/

For Inquiries:
Office of Research Administration,
Shonan Fujisawa Campus
TEL: +81-466-49-3436 FAX: +81-466-49-3594
E-mail: info-kri@sfc.keio.ac.jp
Website of Keio Research Institute at SFC:
http://www.kri.sfc.keio.ac.jp/en/

Disseminating research results broadly

SFC Open Research Forum (ORF)
Keio Research Institute at SFC, with the notionthat dissemination of its achievements to the
public is one of its crucial obligations, holds the
SFC Open Research Forum as the occasion toannounce broadly its research outcomes. In thisforum future prospects and results of many
ongoing research projects of the institute are
introduced to industries, national and local
governments through exhibitions, demonstrations
and symposia.
The institute also makes proposals for societies at
the forum through various sessions such as panel
discussions between experts from industries andgovernments and researchers of SFC. The SFC
Open Research Forum thus intends to facilitateand enhance industry-government-academia
activities at SFC, and is an occasion for the
institute to have external and objective
assessments of its acitivities for development of
its future research plans. The two-day SFC Open
Research Forum 2009 will be held November 23
and 24 at Academy Hills 40, Roppongi, Tokyo.
http://orf.sfc.keio.ac.jp/

SFC Research Yellow Page
Keio Research Institute at SFC runs a web searchservice named “SFC Research Yellow Page” topublicize diverse research activities by researchers of
SFC to an even larger number of enterprises andorganizations. The service is for promotion oftransdisciplinary research endeavors leading toactualizations of new research projects as well as
consequent technology transfers and generationsof new businesses through producing
opportunities of encounter between social needs
and research activities at SFC.
http://www.kri.sfc.keio.ac.jp/kris-yp/

CampusSFC Open Research Forum 2008

21 Shonan Fujisawa Campus (SFC)

SFC Research Yellow Pages

Shonan Fujisawa Campus
SFC ResearchConsortium

SFC ResearchConsortium

SFC ResearchConsortium

Contract /Joint ResearchContract /Joint ResearchContract /Support/
Joint Research Aid Projects
Support/Aid Projects

Support/Aid Projects

World - Leading Fusion Research Technology
Laboratory

SFC Research Consortium

The Keio Research Institute at SFC provides alaboratory system which enables SFC's
researchers to form research groups with people
who have different academic backgrounds yet
share the same research interests and objectives.
These groups carry out interdisciplinary
collaborative research projects. Currently, thefollowing 15 laboratories are active (as of June 1,2009):The SFC Research Consortium is a unique form of
research collaboration in which the university sets
the central research theme, invites a number ofexternal organizations such as businessenterprises and governments for collaborations,and tackles large research issues while sharing
mutual benefits.
Currently, the following 12 consortium projects areactive (as of June 1, 2009):· Career Resource Laboratory· Internet Research Laboratory· Geo-informatics Laboratory· Systems Biology Laboratory· Auto-ID Laboratory· Ubiquitous Computing & Communication· Building Advanced Information Infrastructure· Sharing Human Intellect Project· VCOM· VSI (Virtual Systems Institute)· E-CELL Consortium· DVTS (Digital Video Transport System)

Laboratory· Platform Design Laboratory· Healthcare Informatics Research Laboratory· Keitai Laboratory· Interaction Design Laboratory· Community Collaboration Laboratory· Open Wireless Broadband Platform Laboratory· Asian Laboratory· Mieru-ka Laboratory· Advanced Web Application Laboratory
http://www.kri.sfc.keio.ac.jp/ja/activity/
laboratory.html

Consortium· e-Care Consortium· Keio SFC Innovation & Entrepreneurship Platform
Consortium· Referenced Code Development for IMS/SIP
system· Unwired Research Consortium· Internet Business Innovation consortium· Regional Informatization Research Consortium
http://www.kri.sfc.keio.ac.jp/en/activity/
consortium.html

Introduction to Case Studies
Case Study 1: Faculty ofEnvironment and Information
StudiesAtsushi Shinjo Laboratory
Agricultural Platform Building
Project
The Shinjo Laboratory undertakes
the building of a next-generation
agricultural platform that utilizes IT.
The laboratory aims to realize highreturn, low-risk agriculture byaccumulating the superior cultivation
know-how of veteran Japanese
producers, whose experience has "Dainou"
been fostered in a small country,
using sensor networks, and making this knowledge explicit
using data mining. This is expected to contribute to further
production improvements by veteran producers anddecreases in the cultivation risks faced by new agriculture
entrants. Presently, farming families, retailers, andwholesalers in various areas in Japan are participating, andapproaches using various agricultural products are being
advanced.
The photograph shows the "Dainou", where juices are madefrom tomatoes that have been cultivated in the experimental
farm. The name is taken from a passage in Yukichi
Fukuzawa's book "The Advancement of Learning", whichsays, "If you enter into studies, you should study hard. If youpractice agriculture, you should practice large-scale
agriculture." The juice has a richly flavored taste.l
Case Study 2: Graduate School of Media andGovernance, Faculty of Environment and Information
Studies
Hiroto Kobayashi Laboratory; Use the "Trees/Wood",
Shiga Prefecture, Nagahama City
Tane Village Reclamation Project
The Kobayashi Laboratory
is making progress on a
projecttorevitalize
declining mountain villages
by using local forests andtraditional wooden oldstyle houses. In areas
plagued with problems
such as depopulation, lowbirth rates, and damage "Reinforcing old style houses by using
due to animals, the new materials"
Kobayashi Laboratory is renovating old-style homes andconstructing new ecologically friendly homes by using woodfrom local forests, and making policy proposals for forestry
industries. This is a plan to increase number of young
families that return. In addition, fixing amounts of CO2 byappropriately using wood materials, reforestation, and thecreation of new life styles are being targeted that are
possible especially because of the small regional circulation
systems.
http://hirotolab.sfc.keio.ac.jp/

Ground-Breaking Partnerships with Industry, Government, and Academia
SFC Forum

Venture Incubation Support

The SFC Forum is a "place" for communication
where leaders of the business world anduniversity staff can carry out discussions over awide range of fields.
In the 2009 program for the regular lunch
meetings, which are a pillar of the movement,
seminars by instructors in various specialist fields areprovided under the theme of "Our Sense ofThought and History".
http://www.sfc-forum.sfc.keio.ac.jp/

Keio University has set up incubation facilities(Keio Fujisawa Innovation Village) in cooperation
with the Organization for Small & Medium
Enterprises and Regional Innovation, Fujisawa
City, and Kanagawa Prefecture.
These facilities are offered for rent, subject tolocal conditions suitable for industrial startups, tothose who wish to utilize the fruits of university
research to create new businesses, or to those
who wish to form new companies in partnershipwith university researchers who already havesuitable expertise.
A number of incubation managers are available
on-site to give support such as advice on industrial
startups and matchmaking with corporations.
Since the initial public offering in November 2005,
the facilities have maintained an occupancy ratioof over 90%, and activities leading to industrial
startups are continuing.

Keio Fujisawa Innovation Village

SFC forum

Shonan Fujisawa Campus (SFC)22

Shiba-Kyoritsu Campus

Research Centers

For Inquiries:

Shiba-Kyoritsu Campus
Platform for the dissemination of
information to guide the future ofpharmaceutical sciences

The Group for Research Administration,
General Affairs Office, Shiba-Kyoritsu campus
1-5-30 ShibaKoen, Minato-ku, Tokyo,105-8512 Japan
TEL: +81-3-5400-2653
http://www.pha.keio.ac.jp/
E-mail: skc-shien@adst.keio.ac.jp

Faculty of Pharmacy / Graduate School of Pharmaceutical Sciences
The Faculty of Pharmacy and the Graduate School of Pharmaceutical Sciences were set up in April 2008 as the result of a merger with Kyoritsu University of Pharmacy.
After this merger, we continued to use the equipment and facilities at the Shiba-Kyoritsu campus in Shiba koen, Minato Ward for education and research. Over theperiod of eight decades since its establishment in 1930, Kyoritsu University of Pharmacy has turned out some 13,000 pharmacists and pharmaceuticalresearchers and has attained a leading position in the field of pharmaceutical research. By carrying on this outstanding track record and building on thecomprehensive capabilities of Keio University, we hope that this new Faculty and Graduate School will continue to lead the way forward in the field ofpharmaceutical sciences with regard to education, research and contributing to society.

Aims of the Graduate School of Pharmaceutical Sciences
Pharmaceutical sciences are under increasing pressure to deliver results not only for the benefit of society but also
for improving the quality of medical care. To promote the latest medical advances and contribute to the nation’s
health, the mission of the Graduate School of Pharmaceutical Sciences is to foster the ability to gather
information from around the world, acquire knowledge of advanced leading-edge medical treatments, andeducate talented individuals with specialist skills.
At the Graduate School of Pharmaceutical Sciences, we carry out advanced pharmaceutical education andresearch in a diverse range of pharmaceutical disciplines including pharmaceutical science, chemotherapy,
biochemistry, drug targeting (delivery), patient compliance instruction/drug dispensing, medical productinformation, pharmacokinetics, pharmacology and pathology. Our aim is to produce researchers and engineers
capable of developing new medical products, and to nurture talent in all manner of situations including clinicalresearch organizations (CROs), food manufacturers, the chemical industry, developers of cosmetics, and government facilities.
In each of these fields, we aim to incorporate international aspects into the education and research activities at the Graduate School in order to produce
individuals who are capable of operating on an international level.

Collective strengths of Keio University· Graduate School of Medicine(Graduate School GP joint project)· Graduate School of Science and Technology· Graduate School of Health Management· School of Medicine· Faculty of Science and Technology· Faculty of Environmental Information· Faculty of Nursing and Medical Care
· Shin-Kawasaki Town Campus· Tsuruoka Town Campus· Keio University Medical School Hospital(training for pharmaceutical students)

Platform for the dissemination of information to
guide the future of pharmaceutical sciences

Links with other organizations

Graduate School of
Pharmaceutical Sciences· University / graduate school· Foreign academic exchanges· Hospitals and pharmacies oftraining partners· Research laboratories· Local government(Tokyo city, Minato ward, etc.)· Corporations (joint studies,
research commissions)

Major inpharmaceuticalscience

Major inpharmacy

Major in clinicalpharmacy

Faculty of Pharmacy (pharmacy / pharmaceutical science)· Pharmacy media center· Center For Molecular Target· RI laboratory facilities
Drug Research· Shiba-Kyoritsu ITC· Faculty of Pharmacy dispensary· Laboratory animal breeding facility · Medicinal plant garden

Shiba-Kyoritsu campus

Center For Molecular Target Drug ResearchThis center was established to contribute widely to the development of molecular targeted therapeutic research and to efficiently promote the formation of a DVD
research and development center for cell signaling targeted drug discovery in support of strategic research by private universities and the Ministry of Education, Culture,
Sports, Science and Technology (MEXT). It does this by bringing together leading researchers at the Graduate School of Pharmaceutical Sciences and bycarrying out basic research and development. The center also takes care of the administrative and business aspects of research apparatus necessary forleading-edge research.

Nuclear magnetic resonance (NMR) equipment
This equipment obtains information about the 3D structure and specificnuclear bonding states in chemical compounds by subjecting them toelectromagnetic pulses tuned to resonate with atomic nuclei that spin when
the compound is placed in a magnetic field. This is a powerful technique forthe structural analysis of natural materials and organic compounds.

23 Shiba-Kyoritsu Campus

Flow cytometer
This equipment rapidly separates cells by using various indicators such as
surface antigens. This makes it possible to analyze the properties of cellgroups in a short time, and to separate still-living cells based on theirindividual properties.

Confocal laser scanning microscopeThis microscope can produce high-definition 3D visualizations of thestructure of biologically active molecules such as proteins and nucleic acids,
and the locations of these molecules inside cells. Uses include making
prolonged observations of living cells, and stimulating cells with light of a
specific wavelength.

Shiba-Kyoritsu Campus

From drug discovery to clinical trials — performing
extensive “Pharma Sciences” research to exploit
the multi-faceted nature of pharmaceutics
At the Graduate School of Pharmaceutical Sciences, we aim to build on the collective
strengths of Keio University while improving our research level links with othergraduate schools, and we will continue to promote links between government,
business and academia in the field of pharmacy by promoting exchanges of students andteaching staff. We not only aim to teach and research the latest technology, but we arealso working at further strengthening our research infrastructure by actively inviting
eminent researchers from outside the university, especially from foreign educational
establishments.

Supporting the formation of a strategic research infrastructure
In addition to the independent research achievements made in each of the 20 or
so courses we have on offer, the Graduate School of Pharmaceutical
Sciences has also been selected to participate in the Strategic ResearchBase Development Program of the Ministry of Education, Culture, Sports,
Science and Technology (MEXT), which is a cross-disciplinary research
project that includes participation from external organizations. In the 2009
academic year, one new subject was selected, and we are now working on threeresearch projects.

Formation of a research centre in cell signaling drug discovery formolecular targeting therapies

Links between industry, government and academia —Research examples
Ministry of the Environment: Development of a aqueouschromatography system with lower environmental impact
In this study, we are developing a novel chromatography technique that uses noenvironmentally harmful organic solvents and requires no waste water treatment. We arealso developing a sophisticated analysis method for biological samples andenvironmental samples based on this chromatography technique. In 2005, the National
Institute for Environmental Studies and a group led by professor Hideko Kanazawa of thedivision of Physical Pharmaceutical Chemistry began working on a study commissioned by
Ministry of the Environment. Substantial progress is being made towards achieving the initial
objective of this study, which is to establish environment analysis methods that areenvironmental friendly.

Development of a aqueous chromatography system with
reduced environmental impact
Hydrophobic samples

Hydrophobic
Very weakinteraction

Hydrophobic
Elution accompanyinghydrophobic
interaction

Vitamin C60 BioResearch Corporation
The effects of antioxidant, fullerenes, on inflammation andphysiological responses(2009–2013 research representative: Professor Hideko Kanazawa)Due to recent pharmaceutical developments including the development of moleculartargets, substantial improvements have been made in the treatment of hitherto intractablediseases, and as a result many patients now experience a better quality of life. We aim to leadthe world in drug discovery R&D by establishing a research system with deeper links tofacilities such as the Graduate School of Medicine and Graduate School of Science andTechnology centered on the Center For Molecular Target Drug Research which wasestablished as a research center in the Graduate School of Pharmaceutical Sciences.
Specifically, we will construct a centralized drug discovery research system that brings
together the know-how and technology of drug discovery, such as drug design andsynthesis, drug screening (D; design), analysis of pharmacological / biological action,
investigation of pharmacokinetics and metabolites (V; validation), and drug delivery (D;delivery). Furthermore, by strengthening our research links with other universities, we aim to
discover new drug discovery targets and seeds originating from universities, and toencourage new growth in practical research.

Fullerenes exhibit various novel activities such as antioxidant effects, suppression ofcancer cell proliferation and antiviral activity. These are being clarified by the division of
medicinal chemistry, the Graduate School of Pharmaceutical Sciences, Keio university, andare being put to practical use in cosmetic products linked to their antioxidative activity. In
this funded research, we are studying the anti-inflammatory effects of fullerenes
together with the venture business Vitamin C60 BioResearch Corporation.

Antiviral activity
Antioxidative activity
Suppression of cancer cell proliferation

Establishment of efficient drug development method andside effect reduction method by analysis of factor that influences
pharmacokinetics(2007–2011 research representative: Professor Tadahiko Mashino)
It takes significant cost and time to develop drugs, and the success rate is very low. This ispartly due to the pharmacokinetics of candidate compounds, whereby candidates thatshow good activity in vitro often fail to result in useful drugs due to issues with their in vivo
kinetics. The side-effects and interactions of drugs are also closely related to their in vivo
kinetics. To address this issue, we aim to make drug development more efficient andreduce side-effects and drug interactions by developing methods for improving
pharmacokinetics by analyzing the two factors, “the chemical structure of candidate
compounds” and “the control of transporters and metabolic enzymes”. In the search for new
drug candidate compounds, pharmacokinetic prediction systems are also being
developed, but these are passive predictions based on the analysis of prior data. We are
therefore actively analyzing factors that have pharmacokinetic effects by carrying out a wideranging study including fields from organic chemistry, natural products chemistry,
molecular biology, analytic chemistry and clinical research.

Development of new treatments for intractable diseases based on
clarification of molecular mechanisms in response to stress

Funded research achievements• Pharmaceutical tests in the phase III clinical trials of famciclovir in the• treatment of herpes zoster• Action of prostaglandin D2 receptors (DP) on activity of the lymphocyte• cholinergic system• Performance evaluation of the newly-developed HPLC column, and its •• application to real (clinical) samples• New medication methods for novel compounds and known compounds• Effects of MEK inhibitors on the expression of P-glycoproteins• Creation of novel anti-human urate transporter-1 (URAT1) antibodies• Idiosyncrasies of transporter inhibition, and the effects of these compounds• on transporter expression• Investigation of the social contribution of OTC pharmaceuticals

Research of medical systems(2006–2010 research representative: Professor Yoshikazu Sugimoto)A stress response is a natural defense mechanism whereby a living organism protects
itself from various external stimuli. However, in recent years it has become clear thatproblems such as neurological disorders and allergic diseases can be caused by failure ofstress response mechanisms, or even by stress responses themselves. In cancer
treatments, the stress response of cancer cells leads to increased drug resistance andapoptosis resistance, so controlling the stress response of cancer cells is thought to be
essential for increasing the efficacy of cancer drug treatments. This project aims toanalyze biological stress response mechanisms in such terms as oxidative stress,
inflammation, allergies and reactions between cancer and drugs, and to develop new
drugs that are effective at weakening or modifying the stress response. In this way, we hope
to contribute to the development of preventative medicines, diagnostic methods andtreatments for diseases that are on the increase in our ageing society, such as cancer,
neurological disorders, heart disease and allergic disease.

• Investigation of population pharmacokinetics parameters for the design of• early-stage administration of vancomycin hydrochloride to newborns and• infants with congenital heart disease• Investigation of tacrolimus and azole antifungal agent drug interactions in• hematopoietic stem cell transplant patients• Assessment of malaise in gynecological patients treated with weekly doses• of paclitaxel and carboplatin• Analysis of adenosine uptake mechanisms using rat placental brush border• membrane vesicles• Investigation of patient background factors related to thrombocytopenia and• the state of linezolid use• The effects of helicobacter pylori and QOL changes in patients on low• dosage aspirin with upper gastrointestinal disorders
Shiba-Kyoritsu Campus

24

For Inquiries:

Research Centers

Shin-Kawasaki Town Campus

Shin-Kawasaki Town Campus
Open and Cutting-edge Research
Facility Pursuing IndustryGovernment-Academy -Region
Collaboration

Shin-Kawasaki Town Campus
Shin-Kawasaki Frontier Research and Education
Collaborative Square
7-1 Shin-Kawasaki, Saiwai-ku, Kawasaki, Kanagawa,
212-0032 Japan
TEL: +81-44-580-1580 FAX: +81-44-580-1570
http://www.k2.keio.ac.jp/
E-mail: k2-tc@adst.keio.ac.jp

The Shin-Kawasaki Town Campus, popularly known as the K2 Town Campus, was established in the spring of 2000 as a facility responsible for cutting-edge joint researchamong industry, government, academy and region through collaboration and cooperation with Kawasaki city. K2 ("K Square") represents the double meaning of (1) Keio(one "K") and Kawasaki (another "K") teaming up and thereby producing a squared effect by joining forces, and (2) the campus square (plaza). Currently, 14 research projects
are being developed and 400 registered researchers (professors, joint researchers and post graduate students) are carrying out interdisciplinary research activities.
The K2 Town Campus is a leading-edge, collaborative, interdisciplinary research-oriented campus. With three central tenets of “Advancing leading-edge research,” “Creating
new industries and business,” and “Contributing to society and the community,” we provide support for various research activities as a campus that paves the way to
a new age. Our three tenets are inextricably bound together.
Advancing Leading-edge Research
Large-scale projects underway at the campus include the “Creating the CoMobility Society” project, funded by the Ministry of Education, Culture,
Sports, Science and Technology (MEXT)’s “Creation of Innovation
Centers for Advanced Interdisciplinary Research Areas” program(Special Coordination Fund for the Promotion of Science andTechnology); the “High-Level Global Cooperation for Leading-Edge
Platform on Access Spaces” project, funded by MEXT’s Global COE
Program, and the “Photonics Polymer for Fiber to the Display” project,funded by Japan Science and Technology Agency (JST)’s Exploratory
Research for Advanced Technology (ERATO).

Providing educational
opportunities such as
seminars and tours

Providing researchachievements
Utilizing KBIC

Advancement ofleading-edge
researchCreating new
industries
and businesses

Contributing tosociety and thecommunity

Creating New Industries and Businesses
In the aim of creating new business, we hold the “Business Matching”
program by matching our research achievements (seeds) from eachresearch project with the needs of businesses and institutions. Also, bypartnering with the Kawasaki Business Incubation Center (KBIC), which issituated just next door to the campus, we deepen the possibility ofcommercializing our research achievements.

(Partnering with Kawasaki City)

Contributing to Society and the Community
In partnership with Kawasaki city, we hold Open campus and Openseminars for community residents and businesses, and provide learning
opportunities concerning science and technology. We are also carrying out
educational and experiential programs on science, such as tours andseminars on electric cars aimed for children.

Revitalizing local industries

Creation of research center
based on industry-government-academy-region
collaborations

Research Projects * Completed in FY2008 ** New Project starting in FY2009
K-Building

Project on Search and Development of Intriguing Chemicals for Health Foods
Daisuke Uemura, Professor, Faculty of Science and Technology

E-Building

ERATO-SORST Koike Photonics Polymer Project
Yasuhiro Koike (Professor, Faculty of Science and Technology)

K-Building

New Generation Terabit Core/Access Network Research Project
Naoaki Yamanaka (Professor, Faculty of Science and Technology)

I-Building

High-Level Global Cooperation for Leading-Edge Platform on Access Spaces
Kouhei Ohnishi (Professor, Faculty of Science and Technology)

K-Building

Project on Advanced Light-Wave Control Technologies
Fumihiko Kannari (Professor, Faculty of Science and Technology)

O-Building

Next Generation Nano-technology Thin Film Project
Seimei Shiratori (Associate Professor, Faculty of Science and Technology)

K-Building

Technology of Air Cleaning for Creating the Comforts of Life
Shigeru Tanaka (Professor, Faculty of Science and Technology)

O-Building

The WIDE Project
Jun Murai (Professor, Faculty of Environment and Information Studies)

K-Building

Project on Naturally Occurring Huge Molecules **Daisuke Uemura (Professor, Faculty of Science and Technology)

O-Building

Future Vehicle Project
Hiroshi Shimizu (Professor, Faculty of Environment and Information Studies)

K-Building

Integrated communication network technology of visible light communication
Masao Nakagawa (Professor, Faculty of Science and Technology)

O-Building

Co - Mobility Society Creation Project
Yuichiro Anzai (President, Keio University)

K-Building

Distributed Real-time Controlling ProjectNobuyuki Yamasaki (Associate Professor, Faculty of Science and Technology)

K-Building

Project on Developing High Reliability of Devices with Mechanical Contacts *Toshiyuki Murakami (Professor, Faculty of Science and Technology)

K-Building

Research Project on Secure and Reliable System Software
Kenji Kono (Associate Professor, Faculty of Science and Technology) **25 Shin-Kawasaki Town Campus

Shin-Kawasaki Town Campus

Promotion of Leading-edge Research
The research projects described in the following are some representative examples of those currently being undertaken at Shin-Kawasaki Town Campus.

“Creation of Co-Mobility Society” MEXT Special Coordination Funds for Promoting Science and Technology
Creation of Innovation Centers for Advanced Interdisciplinary Research Areas
Hironao Kawashima, Director of Co-Mobility Society Research Center
Place an order to the“Local Shopping Mall”.

Send weather
and road information

using remote control
Adopted in 2007 and continued throughout 2008 and 2009, “Creation of a CoPeople get
Mobility Society” is a cooperative project between industry, government andtogether shortly
because it isacademia that aims to promote research and development firmly focused oneasier for themto go aroundprospective practical applications of research findings and to nurture theresearchers and engineers—across faculties and graduate schools—who will
shoulder the next generation. As a cooperative body, five leading companies fromthe fields of information and communications (IT) technology and mobile
A vehicle runningChild using
automatically delivers
technology are participating in the project.
remote control
the goods orderedfrom theThe “co-mobility society,” namely, a creative and civilized society in which“Local Shopping Mall”.
everyone from children to the elderly can move around freely and safely,
Commute to school safely
intermingle easily, and live comfortably, is the target of this research project—which aims to create the social infrastructure for underpinning such a society.
This research is aiming to establish the “co-mobility society infrastructure” for linking the real and virtual worlds by means of expanding and integrating eachresearch theme around the three axes of “community science,” “mobility science,” and “human-harmony science,” creating new hybrid communities, andpropagating these communities through society on a grand scale. Moreover, for application to the everyday world, several model districts were set up, andcooperative agreements were signed with Kurihara city in 2007, Okutama town in October 2008, and Aomori city in February 2009.
For better local communities, creation and dissemination of the models which are applicable to other regions are being undertaken, by means of test runningof small electric vehicles that can run automatically as one way of moving around communities in the co-mobility society, formation of communities thatconsist of “information space” and “real space” for revitalization of downtown areas, remote medical care, verification tests for assuring and communication
channels during disasters.

High-Level Global Cooperation for Leading-Edge Platform on Access Spaces
Program leader, Professor of Graduate School of Science and Technology, Kohei Ohnishi
To develop a world-wide stronghold for the global research cooperation, at Shin-Kawasaki Town Campus,
Building I, about 100 affiliated researchers and students (including research assistants, RAs) are involved in
cutting-edge research activities on the following four projects, (i)Basic engineering physics for innovative
photonic/electronic device creation; (ii) Environment-embeded device technology, (iii) Real-world and realtime network for multi-dimensional processing and communication, and (iv) Perception and expression
technology.
FY2008 produced many achievements in the field of international cooperation activities such as international
workshops at nine overseas universities of project partners. At the Shin-Kawasaki Town Campus, special
lectures—to which 30 researchers who are active overseas are invited—were held.
Furthermore, RAs and researchers took the chance to study from a global perspective with a number of
researchers at the forefront of various fields—like Professor Asif Sabanovic of Sabanci University, Turkey,
who resided on campus 11 months from May 2008 to perform collaborative research—who participated inthese educational activities (such as lectures).

Creation of new industries and businesses“Company-business matching”
In 2008, discussions, mainly with industrial researchers, on the possibility of
new manufacturing and new businesses were held a total of two times.
First discussion: October 4, 2008
Conduct: Ohnishi Research Laboratory (Building I), and Koike ResearchLaboratory (Building E)
Second discussion: 7 February, 2009
Conduct: Uemura Research Laboratory (Building K),
Kawasaki Business Research Center (KBIC)
At the incubation facility set up by Kawasaki city in 2003, researches aiming tostart or develop businesses based on the results of the projects. (including
already commercialized research laboratories) are currently underway.

Contributions to Society and Regions
Open campus
At the 2008 open campus, opened by addresses of Yuichiro Anzai, President of
Keio University and Takao Abe, Mayor or Kawasaki city, all projects weredisclosed, and a great number of citizens, students, and staff of various
companies attended. Date held: 4 October, 2008
Open Seminar
As a cooperative project with Kawasaki city, open seminars in which citizens(including many youngsters) and business people could experience cuttingedge technology in their own backyard, were held on the three occasions
detailed as follows:First seminar: 4 October, 2008; “Telehaptics” (remote medical care)(Lecturer: Kohei Ohnishi, Professor of Faculty of Science and Technology)
Second seminar: 4 October, 2008; “Communications by light! Let’s try to
make light-string phones!” (Lecturer: Naoaki Nakayama, Professor of Faculty of
Science and Technology)
Third seminar: 7 February, 2009; “Effective utilization of marine creatures inmedical fields and the Nobel Prize.” (Lecturer: Daisuke Uemura, Professor of
Faculty of Science and Technology)
Shin-Kawasaki Town Campus

26

Tsuruoka Town Campus

For Inquiries:

Research Centers

Tsuruoka Town Campus
The world’s leading pioneer in
Integrative Systems Biology

Tsuruoka Town Campus
Keio Frontier Research & Education Collaborative
Square at Tsuruoka
14-1 Baba-cho, Tsuruoka-shi, Yamagata, 997-0035 Japan
TEL: +81-235-29-0800 (Main) FAX: +81-235-29-0809
http://www.ttck.keio.ac.jp/
E-mail: office@ttck.keio.ac.jp

In April 2001, Keio University established Tsuruoka Town Campus of Keio (TTCK) in Tsuruoka City,
Yamagata Prefecture, with the cooperation of Yamagata Prefecture and the municipalities of Shonai
region. The cornerstone of the campus is the Institute for Advanced Biosciences (IAB).
Research at IAB is conducted at two facilities: the Center Building and the Bio-lab.
TTCK conducts, closely and jointly with the other campuses of Keio, research and development inadvanced areas and enhances research and educational activities. It proactively transfers newly createdtechnologies to local governments and businesses to encourage industry-government-academia
collaboration, for contributing to regional development as well as to the advancement of science andtechnology in Japan.

Bio-labInstitute for Advanced Biosciences (IAB)The Institute for Advanced Biosciences, Keio University, located in Tsuruoka city, Yamagata prefecture, is a pioneer in the new life science field of "Integrated Systems
Biology".
Using cutting-edge biotechnology, intracellular metabolites can be analyzed comprehensively to construct computer simulation models and that can be applied in fields
such as medical science and also the food industry.
http://www.iab.keio.ac.jp/

Major Research Projects
Ministry of Education, Culture, Sports, Science and Technology

Japan Science and Technology Agency•Global COE Program“Global COE for human metabolomic Systems Biology” (2007-2011)•Basic Research Programs (CREST)“Modeling and construction of simulation environments for Systems Biology”(2004-2008)

Ministry of Health, Labour and Welfare•Health and Labour ScienceResearch Grants
Research on Risk of Chemical Substances:“Research related to the development of methods for evaluating the harmfulness ofchemical substances using metabolome analysis and biomarkers” (2007-2009)•Basic Research Programs (PRESTO)“Development of ultramicro-electrospray ionization approaches for-omics research”(2006-2009)•Bioinformatics Operations“Development of Metabolome MS Spectral Integration Database” (2006-2010)•Health and Labour Science Research Grants
Third Term Comprehensive Control Research for Cancer"Research related to the construction of multidisciplinary treatment algorithms
targeting primary breast cancer based on the introduction of biomarkers, and to theformulation of decision-making processes" (2007-2008)•Comprehensive Support Programs for Creation of Regional Innovation
Science and Technology Incubation Program in Advanced Regions(Promotion Research)“Protein phosphorylation display for drug discovery and diagnosis” (2008-2010)•Health and Labour Science Research Grants
Research on Biological Markers for New Drug Development“Biomarker discovery of drug induced hepatitis by global analysis of intracellularmolecules”(2008-2012)•Comprehensive Support Programs for Creation of Regional Innovation
Science and Technology Incubation Program in Advanced Regions(Research for Promoting Technological Seeds)“Effect of waste mushroom bed composted by beetles as organic nursery bed” (2008)•Grant-in-Aid for Cancer Research“Research on Development of new medical treatment based on cancer biology: cancer
metabolomes” (2005-2008)

Yamagata Prefecture and Tsuruoka City

New Energy and Industrial Technology Development Organization“Development of fundamental technologies using Systems Biology (simulations
software techniques, metabolome analysis techniques, genome design techniques,
proteome analysis techniques) and their applications (medical, food, and environment)”(2006-2010)•Functional RNA Project“Analysis of the functions of functional RNA” (2005-2009)

Research System
Major Joint Research Organizations
The Faculty of Science and Technology, the School of Medicine, Shonan
Fujisawa Campus, RIKEN, and Human Metabolome Technologies, Inc.,
BioSigma S.A. (Chile), DENSO CORPORATION, Kirin Holdings Company,
Limited, Kao Corporation, Spiber, Inc.

27 Tsuruoka Town Campus

Educational Activities
The IAB develops and deploys educational activities for students with different
majors in undergraduate or graduate school of Keio University, under the ideal that
advanced research and education should be inseparable. In FY2008, 37
students in the spring semester and 42 students in the fall semester
participated in the programs and activities offered at TTCK.

Tsuruoka Town Campus
Bio Camp
The Bio Camp is a program for students of the Shonan Fujisawa Campus (SFC) of
Keio to spend two semesters (or one semester) at the TTCK and experience thebasics of biotechnology. The program begins with an introduction to thehandling of laboratory instruments because the students have no experience withexperiments. Each student extracts Human DNA and analyzes the gene foralcohol-degrading enzymes, and diagnoses through genetic testing level oftolerance for alcohol is high or low. At the end, the students decode thegenome sequences through state-of-the-art DNA sequencers.
Systems Biology ProgramThis Program is a rare graduate program in the world in the sense thatstudents can earn credits using the abundant research resources of both the SFC(bioinformatics) and IAB (Systems Biology). At TTCK, a number of experiments andlaboratory trainings are provided, such as "metabolome analysis" and"proteome analysis", using the most advanced DNA sequencers, bioreactors, and
CE-MS equipment

EventsCommercialization
A Bio-venture Company from Keio University
Human Metabolome Technologies, Inc. (HMT)
http://humanmetabolome.com/
Human Metabolome Technologies, Inc. (HMT) is a venture company
established in July 2003 by professor Masaru Tomita, professor Tomoyoshi
Soga, and others from the IAB, based on the IAB's measurement and analysis
technology for metabolomes. HMT conducts R&D aimed at industrial
applications in medical care, drug discovery, food fermentation, etc. In October
2003, HMT became the first company to be invested by the Entrepreneur
Assistance Fund of Keio University. HMT has realized cost reductions forcustom metabolome analysis by automating the analytical process. In addition
to broadening the customer base for pharmaceuticals, chemistry, and the foodindustry, HMT is advancing exploratory research on disease biomarkers in theareas of mental and life-style diseases by cooperative research in association
with, for example, public institutions.

Introduction to Bioscience for Tsuruoka Citizens
The introductory bioscience course for general public and taught byresearchers of the IAB. There were 95 participants in FY2008.
Summer Bio College
This is a basic hands-on program in
biotechnology aimed at high school
students in the Keio's affiliated highschools. There were 16 participants in
FY2008.
Keio Summer Bio CampThis is a basic hands-on program in biotechnology for any high school students
from all over Japan. There were 14 participants in FY2008.
Spring Science CampThis is a basic hands-on program in biotechnology for any high school students
from all over Japan. (Sponsored by: Japan Science and Technology Agency)
There were 16 participants in FY2008.

High-throughput and quantitative CE-MS methods which can measure thousands of charged
metabolites. This is a powerful new research device developed by IAB.

Other Related Facilities
Tsuruoka Metabolome Campus was founded in2005 as a research facility by Tsuruoka City whichaims at cluster formation of bioresearch anddevelopment with IAB as its cornerstone. In
addition to IAB's Metabolome group, Human
Metabolome Technologies Inc., RIKEN, School of
Medicine,Keio University, NISHIKAWA KEISOKU
Co., Ltd., BioSigma S.A. (Chile), and Spiber Inc. are on
the campus conducting research.

Tsuruoka Metabolome Campus

Major Awards
November 2001
"Yamagata Keizai Doyukai (Association of Corporate Executives) Grand Prize,
Yamagata Landscape Design Award"

June 2004"Industry-Academia-Government Collaborative Distinguished Service
Commendation (Award of the Minister of State for Science and Technology Policy)"

June 2003"Nihon Kogyo Shimbunsha Award in the 17th Dokusousei wo Kirihiraku Sentan
Gijutu Taishou (Leading-edge Technology for Originality andCreativity)"

April 2005
"First Prize in the 5th Japan Biotechnology Business Competition"

November 2003
"IBM Shared University Research Award"

April 2007
"Prize for Science and Technology in the Commendation for Science andTechnology by the Minister of Education, Culture, Sports, Science, and Technology"

Tsuruoka Town Campus

28

Introduction to publicly funded research
In recent years, Keio University has had an excellent record of accomplishment in obtaining the following prominent competitive research grants. Both theeducational research activities and the research results supported by these grants have been highly regarded in Japan and abroad.

Global COE Program
Out of its original 12 programs under the 21st Century Center of Excellence (COE) project, a government-sponsored initiative to develop advanced research
centers at Japanese universities, Keio University is currently operating seven Global COE programs. These Global COE Programs set up individual research andeducation centers within Keio University’s Advanced Research Centers, which are flexible, interdisciplinary organizations that ensure mobility without any
boundaries imposed by faculties or graduate courses. Each program works together with existing education and research programs. Through the these
programs, internationally distinguished research and education centers are being created through the strengthening and enhancement of the education and researchfunctions of Keio’s graduate school, and processes to foster the development of young researchers have been established. Thus, through these programs, Keio ismoving forward to create a university that meets the highest global standards.
Centers Selected in the Global COE Program
Page

Adopted Year

Field

Home Campus＊

Program title

Program Leader

P.31

2007

Life sciences

Shinanomachi

Global COE for Human Metabolomic Systems Biology

Makoto Suematsu, Professor, Graduate School of Medicine

P.31

2007

Information sciences, electrical andelectronic sciences

YagamiHigh-Level Global Cooperation for Leading-Edge Platform on Access Spaces (GCOE)

Kouhei Ohnishi, Professor, School of Science and Technology

P.32

2007

Humanities

Mita

Center for Advanced Research on Logic and Sensitivity

Shigeru Watanabe, Professor, Graduate School of Human Relations

P.32

2008

Medical sciences

Shinanomachi

Education and Research Center for Stem Cell Medicine

Hideyuki Okano, Professor, Graduate School of Medicine

P.33

2008

Mechanical, civil engineering, architectural
Yagami, Hiyoshi
and other fields of engineering

Center for Education and Research of Symbiotic, Safe and Secure System Design

Takashi Maeno, Professor, Graduate School of System Design and Management

P.33

2008

Social sciences

Mita

Raising Market Quality - Integrated Design of Market Infrastructure

Naoyuki Yoshino, Professor, Graduate School of Economics

P.34

2008

Social sciences

Mita

Designing Governance for Civil Societies

Yoshihisa Hagiwara, Professor, Graduate School of Law*Home Campus: Affiliate region of research representative

Special Coordination Fund for the Promotion of Science and Technology
The Special Coordination Fund for the Promotion of Science and Technology is operated by the Ministry of Education, Culture, Sports, Science, and Technology inaccordance with the plans and objectives of the Council for Science and Technology Policy. The fund provides competitive grants for policy-directed research activities.
The funds the provided are used for policy-directed research projects that have high effectiveness. The funds support projects such as the following: projects that
relate to government ministry policy initiatives; projects that cannot be covered by the policies of each ministry; projects from which synergistic effects can be expected
due to inter-agency cooperation; and projects that require a flexible approach. The overall objectives of the Council’s provision of these funds are:(1) Reform of scientific and technical systems to create and apply excellent results,(2) Strategic response to emerging, promising research areas, and(3) Promotion of internationalization of scientific and technical activities.
In line with the above Council objectives, Keio University focused in FY2008 on developing young researchers as well as upgrading and expanding efforts to strengthenscientific and technical exchange. We also made improvements in further promoting scientific and technical systems reform, with respect to continuing, publicly funded
programs.
The following four programs have been set up for 2008 :1) Reform of the Development System for Young Researchers (Promotion of Environmental Improvement for Independence of Young Researchers, Development ofYoung Innovative Researchers),2) Reform of the Support System for Female Researchers (Support Model for Development of Female Researchers, Accelerated Reform of the Support System for
Female Researchers)
3) Creation of a Base for the Regeneration of Local Human Resources 4) Strategic Promotion of Scientific and Technical Cooperation with Africa and Asia
(Creation of a Base for the Development of Strategic Environmental Leaders, Promotion of Joint International Research)
In FY 2008 Keio University adopted three plans for the development of its human resources. To reform its development system for young researchers, it focused on
the development of young scholars who will lead research into the foundations of ‘Cells and Metabolism’ and on the development of medical students with PhDs. To
reform its support system for female researchers (a support model for development of female researchers), it focused on support for female researchers that will
enhance social capital.
Research in Progress from 2008
Affiliation

Position

Research Representative

ProgramResearch Theme

School of Medicine

Professor

Sadakazu Aiso

Fostering talent in emergent research fields

Training Course for Technical Assistants on in vivo Medical Science

School of Medicine

Associate Professor

Kenji Watanabe

Promotion of Versatile Responses to Important
Policy Themes

Scientific Evaluation of Alternative Treatments and Integrative Medicine; Studyand Research of Methodology

Faculty of Science and Technology

Associate Professor

Kenji Kono

Promote Research Activities to Tackle
Important Issues

Producing Highly Attack-Resistant Secure Operating Systems

Faculty of Science and Technology,
Faculty of Environment and Information
Studies, Graduate School of Media andGovernance, etc.

Professor

Hironao Kawashima

Creating of Innovation Centers for Advanced
Interdisciplinary Research

Creating a Co-mobility Society*

Faculty of Environment and I
nformation Studies

Professor

Masataka Watanabe

Strategic Promotion of Science and Technology
in Asia

Development of Environmental Resources Management Technology for
Sustainable Use of Biomass

Research Institute for Digital Mediaand Content

Institute Director

Yuichiro Anzai

Encouraging development of Strategic
Research Centers

Research Institute for Digital Media and Content, Keio University

Affiliation

Position

Research Representative

ProgramResearch Theme

Faculty of Nursing and Medical Care

Professor

Kaeko Yamashita

Developing Models for Supporting Female
Researchers

Project for Developing Social Capital and a Good Working Environment for
Women Researchers*

School of Medicine

Professor

Toshio Suda

Improvement of Research Environment for
Young Researchers

Career development program for young investigators in "Cell andMetabolis Research" (Keio-Kanrinmaru Project)*

School of Medicine

Associate Professor

Koichi Matsuo

Encouraging innovative and creative young
researchers: 2008 academic year

Supporting the PhD Echelons of Medical Students (MEBIOS)*

New Subjects Selected in 2008

*The University President has final responsibility for these research projects.

29 Introduction to publicly funded researchBasic Research Programs
Basic Research Programs are handled by the Japan Science and Technology Agency. In sponsoring these programs, the Agency takes a top-down approach inpromoting target-oriented basic research directed toward the achievement of national government objectives. The purpose of these programs is to create the seedsof new technologies for responding to social and industrial needs and generating future scientific and technical innovation. The key persons in these programs areresearchers from universities, public agencies, and private corporations, and they carry out research through formation of flexible, mobile cross-organizational research
project teams that disband upon completion of the project. This system of directed research programs contrasts with the characteristics of funding for bottom-up
scientific research that places a high value on the proposals of individual researchers. From different aspects, these two systems, like the two wheels of a cart, aredesigned to play a major role in promoting Japan’s science and technology. The Japan Science and Technology Agency (JST) establishes specific areas of research,based on the strategic objectives of the Ministry of Education, Culture, Sports, Science and Technology (MEXT). Under the leadership of its research directors, theJST brings together researchers from industry, government and academia, and sets up the most appropriate research organization.
The JST promotes two types of research—open research and JST-supervised research. .
In open research, a research director designated by the JST calls for submission of research proposals in a research area specified by the JST, selects
proposals, and promotes the work of the researchers selected. Open research has two types: team research, called CREST (Core Research for Evolutional
Science and Technology), and individual research, for path-breaking work to be done by individual scientists.
On the other hand, in supervised research or ERATO (Exploratory Research for Advanced Technology) research targets are based on the unique perspectives of theJST’s research directors. Based on these targets, researchers are brought together, and projects are carried out. This type also includes joint research with overseas
research organizations.
CREST Research Representatives
Position

Name

Research Theme

School of Medicine

Professor

Toshio Suda

Metabolism in Hematopoietic Stem Cells

School of Medicine

Professor

Hideyuki Saya

Analysis of Abnormal Regulation of Cell Differentiation and Drug Development Research by Using Induced
Cancer Stem Cells

School of Medicine

Professor

Akihiko Yoshimura

Reprogramming of Immune System by Modulation of Intracellular Signal Transduction

Faculty of Science and Technology.
Faculty of Science and Technology

Professor

Tadahiro Kuroda

Generation of High-performance, Ultra-low-power, Short-range Wireless Mobile Information System

Professor

Hideo Saito

Technology to Display 3D Contents into Free Space

Faculty of Science and Technology

Associate Professor

Kenji Kono

Producing Highly Attack-Resistant Secure Operating Systems

Faculty of Environment and Information Studies

Professor

Hideyuki Tokuda

A Dependable Operating System for Micro Ubiquitous Nodes

Faculty of Environment and Information Studies

Professor

Masaru Tomita

Development of Modeling/Simulation Environment for Systems Biology

Graduate School of Media Design

Professor

Masahiko Inakage

The Research of Ubiquitous Content Production Authoring System

Affiliation

Position

Name

Research Theme

School of Medicine

Assistant Professor

Motoaki Sano

Metabolomic analysis of heart failure and cardiac senescence

School of Medicine

Associate Professor

Takeshi Miyamoto

Regulation of bone metabolism through osteoclast cell-cell fusion

School of Medicine

Researcher

Kyoko ShirakabePhysiological Roles and Regulatory Mechanism of Ectodomain in Shedding in Innate Immune Response

Faculty of Science and Technology.
Faculty of Science and Technology

Assistant Professor

Eiji Saitoh

Spintronics based on spin currents and spin-photon coupling in dielectrics

Research Associate

Akinobu Yamaguchi

Study in novel electromagnetic properties of modulated and/or periodic magnetic strucure composed ofnanoscale magnets

Faculty of Environment and Information Studies

Assistant Professor

Yasuaki Kakehi

Creation of Real World Oriented Interactive Media for Artistic Expression

Graduate School of Media and Governance

Associate Professor

Yasushi Ishihama

Development of ultramicro-electrospray ionization approaches for -omics research

Affiliation

Position

Name

Research Theme

School of Medicine

Professor

Hideyuki Okano

Nerve Regeneration Strategy Based on Endogenous Neural Stem Cell Activation

Faculty of Science and Technology

Professor

Yasuhiro Koike

Photonics Polymers for Fiber To The Display

Faculty of Pharmacy

Professor

Takeshi Sugai

Synthesis and Utilization of Heterochiral Synthons based on Biocatalytic Transformations

Affiliation

PRESTO Researchers

SORST Researchers*Japan Science and Technology Agency (JST): From the Basic Research Programs website http://www.jst.go.jp/kisoken/ *The list above shows research themes continuing since FY2008.
*Solution-Oriented Research for Science and Technology (SORST) refers to a project that has completed its initial period of examination under the Basic Research Programs and has been continued because it has been regarder as having great potential for future benefits.

FY2008 Kakenhi Distributed by Institution

Grants-in-Aid for Scientific Research (Kakenhi)
Kakenhi or grants-in-aid from the Ministry of Ministry of Education, Culture, Sports, Science andTechnology (MEXT), are subsidies for research in all areas of inquiry, from the humanities and social
sciences to the natural sciences. Grant money is given to various kinds of academic research, from basic toapplied. From research based on the free, inventive thinking of researchers, the grants aim to generate resultsthat will bring about social breakthroughs. Over the years, many research projects done with these grants
have achieved results of the highest order and have received worldwide recognition, from Nobel Prizes toother awards for scientific endeavor given in Japan and overseas.
The program makes use of approximately six thousand judges to conduct peer review of the proposals
submitted. Projects chosen every year are of all kinds, from those in the incubation stage to those at the
cutting edge in their field. The Kakenhi program represents approximately 5% of the government's total
expenses related to science and technology and 40% of the government's total budget for competitive
research funds.
The number of applications submitted in FY2008 was about 137,000 (about 15,781 more than in FY2007).
Among these about 57,000 applications (about 7,575 more than in FY2007) qualified for research funding, andthe total amount (of direct expenses) was about 155, 800 million yen. The table shows the number ofprojects of the top twenty institutions receiving grant money (new and those continuing from the previousyear) in FY2008 and the total amount distributed. The amount received by the top 10 institutions represents 46%of the total amount distributed. In FY2008 Keio University ranked 12th overall and 1st among private
institutions.

Rank

Institution

01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
A
B
B/A
C
C/A

University of Tokyo
Kyoto University
Tohoku University
Osaka University
Kyushu University
Nagoya University
Hokkaido University
University of Tsukuba
Hiroshima University
Kobe University
Tokyo Institute of Technology
Keio University
RIKEN
Chiba University
Okayama University
Waseda University
Kanazawa University
Kumamoto University
Niigata University
Tokyo Medical and Dental University

Number of
Projects

Amount(Million yen)

2,896
2,304
1,952
1,941
1,396
1,351
1,310
911
811
751
701
671
630
606
606
572
537
446
428
405

21,324
14,402
11,074
10,359
5,728
6,513
6,176
3,167
2,623
2,716
4,907
2,476
3,885
1,843
2,022
2,154
1,568
1,536
1,129
1,825
190,644
84,082
44%
107,427
56%

A: Total amount distributed (research expenses) B: Total of top 10 institutions C: Total of top 20 institutions
Source: Japan Society for the Promotion of Science, http://www.jsps.go.jp/j-grantsinaid/* The distribution amount includes direct and indirect expenses.
* Figures of 100,000 yen and below are rounded off.
* Data here is classified by the research institution with which the research representative is affiliated; it may not reflect the overall ranking by institution.

Introduction to publicly funded research

30

Global COE Program [Life Sciences] FY2007

Center for Human Metabolomic Systems Biology
Program Leader: Makoto Suematsu (Professor, Graduate School of Medicine)
http://www.gcoe-metabo.keio.ac.jp/
Graduate School that Uses English as Official Language
According to agreement (conforming to Bologna Agreement operated in EU countries) with
our overseas partner institution, the Karolinska Institute, we have executed all
lectures of the graduate school to held in English since 2008. We also held 17 GCOErelated seminars by inviting outstanding researchers from inside and outside theschool.
Summer School in Partnership with Karolinska Institute and Boston University
The summer school, held for five weeks in July, 2008, differed from conventional
exchange programs based on individual labs or professors. It was a representative
program of 2008, officially organized by between Keio University’s GCOE and
Karolinska Institute, a member of EATRIS (EU equivalent to the GCOE program). The
Summer School consisted of one week of intensive lectures and four weeks of lab
work. A total of six lecturers were invited from the Karolinska Institute and Boston
University. We gave course credits for the first time to six doctoral students from the
Karolinska Institute who attended. We are also planning to organize Winter School 2009at the Karolinska Institute at the end of FY2009.
Student Evaluation Using RA Point System
We established the subject “Metabolomic Systems Biology” (2 units) as an official
graduate school secondary course whose credit can be earned if a research assistant (RA)obtains 30 points or more in a year. This subject is required of all GCOE RAs. In“Metabolomic Systems Biology,” along with learning about metabolism of energy
based on the bioavailability of the components of an organism, students also learn
integrative techniques to solve problems, using biosimulation and computer sciences toefficiently process biological informatics, including genomics, proteomics, andmetabolomics.
Fostering Independent Young Researchers
We are actively obtaining competitive external grants to create an environment that
fosters independent research and trains young researchers. At the same time, in ourroutine efforts we appoint exclusive
instructors for our shared-use researchfacilities.
Strengthening Shared Laboratory
Functions
We have established a division thatserves as the gate window toresearchers around the world for using
technologies and animal resources Summer School in partnership with Karolinska Institutedeveloped by this GCOE program (Such and Boston University (July 2008)
resources and facilities include, twophoton laser scanning microscopy to analyze, cerebrovascular circulation and energy
metabolism or biological behavior of water circulation, mass spectrometric imaging
and HAL: Humanized Animal Laboratory.)
Groundbreaking Metabolomic Systems Biology Thanks to Development of
Leading-Edge Mass Spectrographic Technology
We began building a high-spatial resolution mass spectrometric imaging system as a key
technology to perform quantitative analysis of metabolites in specific regions of the celland to identify low-molecular compounds. We have recently built the technology formapping nucleotide metabolism during cerebral ischemia. Also, by using the multifunction multi-photon microscope in connection with real-time monitoring of energy
metabolism, blood flow, and oxygenation in solid organs such as the brain and liver, weare supporting the in vivo study of cellular and molecular dynamics and analysis of
metabolic functions. To understand the global picture of the regulation of
metabolomic systems, we will create technologies to search for the receptors of
lowmolecular metabolites using affinity nano-beads, and to identify receptors of
extremely small molecules, such as gas molecules, in combination with using mass
spectrometry.

Global COE Program [Information Sciences, Electrical and Electronic Sciences] FY2007

High-Level Global Cooperation for Leading-Edge Platform on Access Spaces
Program Leader: Kouhei Ohnishi (Professor, Graduate School of Science and Technology)
http://www.gcoee.keio.ac.jp/
This GCOE Program, began in 2007, is proceeding in creating an outstanding
international research and education center that produces scientists and engineers
having rich humanity and the skills of actively working in the international arena. On the
research front, we are pursuing new human-centered science and technology in order toprovide digital support that meets the needs of individual activities. We haveestablished targets having levels of higher performance than those based on theconventional information, electrical and electronic technologies, and we are making
progress on coordinated research that integrates areas from photonic/electronic
devices to network communication and haptics. Specifically, to provide advanced
human support in access spaces, we are pursuing research that heightens synergistic
achievements in the following four fields: “Basic engineering physics for innovative
photonic/electronic device creation,” “Environment-embedded device technology,”“Real-world and real-time network for multi-dimensional processing andcommunication”, and “Perception and expression technology.”
Concerning the human development, as of 2008 we have employed 55 COE research
assistants (RAs) who are registered as doctoral students and 10 post-doctoral (PDs)
researchers under the competitive scheme.
Along with being tasked to learn the COE subjects prepared in the Graduate School, theRAs can also make use of double-degree programs, a double supervisor system (thatincludes professors at the overseas core partners and collaborators), international
internships and overseas joint researches. As a result, we will be able to establish career
paths for young PhD-holding scientists and engineers that allow them to participate
actively in the international arena. We also expect to produce new leaders who can be
active in the global society.

(3) Internship program
Four students for long-term internships and six for short-term internships were sent to theoverseas collaborators (including Harvard University, Ecole Centrale de Nantes, andGhent University) to carry out the joint researches on nanotechnology, augmented
reality (AR), and network technology.
(4) Double supervisor system
Four students obtained their degrees from the supervision of professors at theoverseas collaborators (such as the University of California, Berkeley and Università degliStudi di Padova).
(5) Distinguished COE-RA system
Three outstanding students were recognized and given awards.
(6) Educational programs
We held the “Leading-Edge Science and Technology” seminar and a lecture on“Ethics and Copyrights in Science and Technology.” We also had 33 special lectures byprominent researchers for RAs and young researchers, and a winter camp organized by
the RAs themselves.
(7) Presentation of the achievements to society
To present the achievements of our GCOE program to society, we held several events inwhich young researchers presented their research results, such as the Keio TECHNOMALL (December 2008), a PhD paper contest (RA poster session, March 2009) and the
GCOE symposium (March 2009).
(8) Research achievements
We are solidly producing results, with 169 journal papers, 31 invited talks, and 280
presentations at international conferences.

Achievements in FY2008(1) Strengthening international cooperative centers network,
NOE (Network of Excellence)
We signed three new memorandums of agreement, including the University ofWestern Australia, to increase to 39 international partner institutions.
(2) International workshops
We sponsored ten international workshops at the collaborators, such as Imperial
College (UK) and Technische Universität München (Germany), and the total
participants were 314 persons.

Internship at Harvard University

31 Global COE Program

Obtaining the degree under the double supervisor system(professors at the collaborators as the second reader)Global COE Program [Humanities] FY2007

Centre for Advanced Research on Logic and Sensibility
Program Leader: Shigeru Watanabe (Professor, Graduate School of Human Relations)
http://www.carls.keio.ac.jp/english/
The Centre for Advanced Research on Logic and Sensibility (CARLS) is a program for theeducation and research of logic and sensibility. To accomplish this purpose, it has a welldesigned educational program in close collaboration with the Graduate School of Human
Relations. Several research facilities and a program for promotion of publication of research results
support the CARLS.
Educational and Research Programs
We have five education and research teams: Brain and Evolution, Genetics and Development,
Language and Cognition, Philosophy and Anthropology and Logic and Informatics. The teams carryout leading-edge research on logic and sensibility from different points of view and graduate
students participate in the research through official courses of the graduate program. They learn
how to run interdisciplinary research through this participation. Ten students obtained
certificates of completion of the program in 2007 and nine students in 2008.
Educational and Research facilities
CARLS is equipped with several advanced facilities for integrative research with experimental
sciences. An MRI laboratory was started in 2008 and 20 research projects are now running. A
developmental laboratory has NIRS and TOBII. We have also a marmoset laboratory in
Research Park in the School of Medicine and a field station in Tsukuba City.
Program for promotion of publication of research
To facilitate international presentations of research results for young scientists, we areproviding assistance for writing in English. Through this program, young scientists published 51
English papers in 2008.
Domestic collaboration
We collaborate with the Symbolic Cognitive Development Team at RIKEN BSI and carry out joint
research with marmosets. Students at Keio University also run experiments in RIKEN BSI.
International collaboration
We collaborate with several world-class institutes in foreign countries. In 2008, we haveconcluded agreements on collaboration with the University of South Florida in the USA and Gachon
University in South Korea. In 2009, we have made an agreement on collaboration with McGill
University in Canada. We plan to collaborate with around 15 international institutes.
International Education and Research Program
We have international seminars for young scientists. A Keio-Cambridge seminar and a Keio-Gachon
seminar are regularly held in the UK and South Korea, respectively. In 2009, we will start a similarseminar with the University of South Florida in the USA. We are also actively supportingpresentations by young scientists at international congresses and meetings.
Publications
We publish “CARLS Series of Advanced Study of Logic and Sensibility” each year andnewsletters four times a year in addition to English monographs based on our international
symposium. We also have lectures for the general public in Japan and frequent press
releases.
Networking
We have formed a network with the two other Global COE programs at Keio University and started
the Institute of Human Cognition with those programs in 2009. We also created a “Global COE
network of mind research” with other four Global COE programs at other universities and had asymposium at the annual meeting of the Japanese Psychological Association in 2009.
Employment and Financial Support for Young Scientists
Currently we employ five research associate professors, six research assistant professors and 15
researchers. We plan to employ around 40 professors and researchers.
External Evaluation Committee
We have established an evaluation committee consisting of outside members to receive
evaluation of our activities in not only research and education but also in other operations. In 2008,
the committee carried out a review and reported that the program is proceeding efficiently andsmoothly.

Global COE Program [Medical Sciences] FY2008

Education and Research Center for Stem Cell Medicine
Program Leader: Professor Hideyuki Okano, Graduate School of Medicine
http://www.gcoe-stemcell.keio.ac.jp/
Our Global COE (GCOE) Program, “The Education and Research Center for Stem Cell
Medicine,” builds on research established by the 21st COE Program “Basic Study and ClinicalApplication of the Human Stem Cell Biology and Immunology” to create infrastructure forstrategically fostering human resources and to create a center for education and research on stem
cell medicine. We seek to establish an academic domain around the concept of “stem cell
medicine” that incorporates a wide range of fields in medical science. Furthermore, our goal is tofoster the next generation of scientists who can become the core of a more international
network of stem cell researchers. We do this by fostering the capacity for self-renewal(creating a virtuous cycle of building a series of education and research structures),multipotentiality (cultivating versatile personnel), and migratory ability (exchanging personnel tobuild an international cooperation framework).
With the following areas/subgroups, our GCOE Program seeks to implement clinicalapplications of regenerative medicine from basic research:
1. Regulation of tissue stem cell and in vivo experimental medicine
2. Inflammation/immunological control and tissue regeneration
3. Development of diagnostic and therapeutic methods targeting cancer stem cells andepithelial mesenchymal transition in patients with cancer
4. Development of regenerative medicine for intractable diseases
5. Practical implementation of feasible regenerative medicine
We are advancing our research with close cooperation among these subgroups.
In 2008, the start of the GCOE program, we succeeded in transplanting neural precursor cells
derived from mouse induced pluripotent stem cells (iPS cells) to model animals with spinal
cord injuries (thoracic cord injury model) and restoring motor functions. This achievement was
widely reported in newspapers and other mass media. In addition, we succeeded in inducing
myocardial cells from human iPS cells, in establishing iPS cells from patients with familial
Parkinson’s disease, and in establishing a highly efficient and high-quality process of inducing iPS
cells using highly pure mouse and human mesenchymal stem cells (MSCs). We have been able to
make a variety of progress in the field of iPS cell research, which has drawn attention inrecent years. Each subgroup of the program has reported research achievements one after
another, such as: the elucidation of the molecular basis for each type of stress tolerance ofhematopoietic stem cells using FOX03ai; establishing a method of purifying spermatogenic
cells and discovering differentiation control abnormalities through response abnormalities togenetically damaged spermatogenic cells; elucidation of control mechanism using the PI3K
pathway, which expresses inflammatory cytokine in dendritic cells; building a model of listeria

encephalopathy and analyzing the immune system within the brain; discovery of the promotion andinhibition of cancer cell metastasis mediated by immune suppression using epithelialmesenchymal transition (EMT) of cancer cells; in vivo analysis of the cell cycle throughproduction of transgenic killifish expressing GFP-histone H2B; transplantation of human ESinduced myocardial cells to super-immunodeficient mice; studying the possibility oftransplanting neural crest stem cells to treat Hirschsprung’s disease; and elucidation of neural crest
stem cells derived from bone marrow, dorsal root ganglion, and facial skin.
For activities related to education and international exchange, we held events such as theinternational symposium “The Forefront of Regenerative Medicine” (Jan. 1, 2009); the 5th Keio
University Advanced Science and Technology Symposium, commemorating the 150th
anniversary of Keio University, entitled, “Groundbreaking iPS: The Future of Medical Research”(backed by this GCOE program and featuring four subgroup leaders as speakers) (Feb. 4, 2009); the17th GCOE Seminar; and the COEX Meeting (as of March 2009, the 61st meeting since thestart of the 21st COE Program in October 2003). These events provided valuable experiences toyoung researchers and graduate students belonging to our GCOE program. We are off to an
excellent start this year, the first year of the GCOE program, with unusually abundant results. Basedon such achievements, we plan to further enrich and deepen our research and education in the
coming years.
Main Events of 2009
Stem Cell Symposium(May 15-16, 2009, co-sponsored by the center, at Izumi Garden Gallery)
GCOE Workshop to Improve Presentation Skill 2009
(June 18-25, 2009, at Shinomachi campus)
GCOE Summer School 2009 KeioxLund(August 3-4, 2009, at Shinomachi campus)

Young researchers receiving
Dr. Hideyuki Okano lecturing at the Human iPS stem cell colony
guidance from Dr. George Q. Daley symposium “Groundbreaking iPS:
(Jan. 1, 2008 symposium)
The Future of Medical Research”
Global COE Program32

Global COE Program [Mechanical, Civil, Architectural and Other Fields of Engineering] FY2008

Center for Education and Research of Symbiotic, Safe and Secure System Design
Program Leader: Professor Takashi Maeno, Graduate School of System Design and Management
http://www.gcoe-s4design.keio.ac.jp/en/index.html
The Center for Education and Research of Symbiotic, Safe and Secure System Design isdeveloping leaders for the age of globalization who have both basic skills andcomprehensive ability by giving full play to the global top-level achievements in basic
scholarship at the Graduate School of Science and Technology and the strength oforiginal approaches to system design management education of highly skilled
professionals (mainly working people) at the Graduate School of System Design andManagement, which was newly established in 2008. Last fiscal year in its inaugural year,
the Center implemented a system design organization that satisfies the goals of bothlarge-scale system design and diverse values such as the environment and safety. The
Center has begun discussions and information exchanges on the theory of symbiotic andsafe system design and, at the same time, initiated specific education and research on
symbiotic and safe system design.
1. Symbiotic and safe system design education
The Center has implemented an international collaborative course system comprised of“Basis for System Design and Management,” “Design Project (ALPS: Active Learning
Program Sequence),” “Safe System Design,” “Requirement Engineering,” “System
Architecting,” “System Integration,” and “Complex System Design” in parallel withinternational, collaborative practical education for young researchers. In cooperation with
Massachusetts Institute of Technology and Stanford University, the “Design Project(ALPS)” course explores major themes, such as “sustainable community,” in which
students in groups not only work on problem establishment and solution concepts,
they give concrete shape to and verify their concepts. Students not only acquire
professional ability and system design ability, they gain a broad range of skills fromleadership and teamwork to presentation and an international way of thinking. To
consolidate symbiotic and safe system design education, the Center has establishedvarious support systems such as economic assistance, research guidance, internship, anda voluntary student organization.

2. Symbiotic and safe system design research
The Center has two pillars of research.
(1) Research related to educational systems for symbiotic and safe system design
Based on collaboration between COE members in Japan and overseas, the Center has
advanced tangible joint research related to new methodology for system design
education. Specifically, research has begun on educational achievements and issues
centered on the Design Project (ALPS) comprised of international collaborative
lectures, including lively international cooperation and discussions.
(2) Research related to symbiotic and safe system design
To conduct symbiotic and safe system design research in areas from energy tomobility, the Center has implemented a system design research framework—that is
symbiotic and safe, large-scale, and complex—as a pillar to support methodology,
modeling, simulation, energy systems, mobility systems, and human systems.
Collaboration based research has already begun.
3. Clarification of assessment scale
The Center has established an assessment board comprised of outside experts from thebusiness world. The board has begun to conduct external assessments of the Center’s
education and research achievements. The main comment from board members isthat while the Center has original, outstanding education and research that meet thedemands of society, the Center’s achievements need to be more aggressively
disseminated to the outside. Going forward, the Center needs to actively
communicate information about its achievements to the outside. To quantify theeducational effect, the Center has begun to conduct questionnaire surveys ofstudents. COE members have also begun self-assessment and improvement activities.
As described above, in addition to a good quantifiable assessment scale, the Center has
implemented a system that can quantify the return of education and researchachievements to society and students. Looking ahead, the Center asks for support andcooperation from within and without Keio University in this education and researchendeavor.

Global COE Program [Social Sciences] FY2008

Raising Market Quality – Integrated Design of “Market Infrastructure”
Program Leader: Professor Naoyuki Yoshino, Graduate School of Economics
http://www.coe-econbus.keio.ac.jp/

1. Subprime mortgage loan crisis and the low quality of the market
Many Economic issues in these days seem to be based on the low quality of market suchas sub-prime housing loan problem. This year’s research focuses on how to improve thefinancial market in the world so as not to cause another financial crisis. The Global COE
of “Raising Market Quality” had forum and panel discussions not only our researchmembers but also inviting policy makers from the Ministry of Finance, the Central
Bank of Japan. It is published as a book titled “Debate: Sub-prime Loan Financial
Crisis” (Keio University Press, 2009). Market infrastructure such as laws, regulations, credit
rating agency, investment banks, insurance companies etc. which created sub-prime loan
financial crisis has to be improved. Market infrastructure has to be up-graded.
2. Research on Market Quality by use of Households’ Panel Data
Keio Households’ data collects Japan’s households behavior every year. Based oncontinuous annual households’ survey data allows us to examine the impact of
current financial crisis on Japanese labor supply, housing investment behavior, andhouseholds’ allocation of financial assets. Keio University-Kyoto University Global
COE started to exchange households’ data with Princeton University (USA) andErasmus University (Netherland).
3. Current Financial Crisis and the improvement of the quality of the Asian
Financial Market
Asian Economic Panel (AEP) Meeting is held every year to discuss how to upgrade thevarious markets including financial market in Asia. KIEP (Korea Institute of Economic
Policy), Columbia University (USA), Thammasat University, University of Indonesia,
University of Malaya, University of Philippines, University of Hong Kong, Swedish
Institute, Australian National University and Former Finance Minister of Thailand,
Former Deputy Governor of Bank Indonesia are members of AEP Meeting. Best papers
from the AEP meeting are published from MIT press every year.
4. Market Quality Research on in the field of History and Theory
The market quality research is applied to the field of history and economic theory. Such

33 Global COE Program

historical research as the Shanghai electric power market at the beginning of the 20th
century, the human excrement market in the prewar period of Tokyo, the railway
crosstie market in the prewar period, the fertilizer market in colonial Taiwan, and the hotspring resource management in modern Japan are examples of the application ofmarket quality research on historical analysis. Market quality research in economic
theory was initiated by Professor Makoto Yano and it is applied to the subprime loan
market. The Global COE has developed a new bargaining theory introduced for pricecompetition which is related to the fairness of the business practice.
5. Graduate School Education in Market Quality
Three basic subjects on market quality had been established as GCOE (Global COE)
through collaborative cooperation between Keio University and Kyoto University.
Three courses provide a variety of attractive lectures, such as 1) The theory of
economic dynamics to raise market quality, 2) Panel data design, analysis, theory, and 3)
Market infrastructure design applicable to economic policy making. Further, the GCOE
offers a basic course work to write doctoral dissertations. The course covers how to set
up the topic of the thesis, how to real related literature, dissertation structure, andpresentation techniques. Graduate School education is aimed to improve quality of
the PhD thesis and increase the number of graduate students to complete their PhD
theses.

Global COE research presentation

Global COE Program [Social Sciences] FY2007

Center of Governance for Civil Society (Designing Governance for Civil Society)
Program Leader: Professor Yoshihisa Hagiwara, Graduate School of Law
http://www.cgcs.keio.ac.jp/
The Center of Governance for Civil Society (CGCS)—selected as a Global COE in 2008 by the
Ministry of Education, Culture, Sports, Science and Technology—conducts world classeducation and research on “governance for civil society” not only in Japan, but in collaboration withcenters in the US, Asian, and other overseas countries. The CGCS educates and trains young
researchers to enable them to become active internationally. To achieve this objective, theCGCS has established the following research activities in line with the COE Implementation Plan.
The establishment of the CGCS
The Center of Governance for Civil Society (CGCS) was launched in August 2008 after
recruiting young researchers widely from Japan and overseas for each educational andresearch unit.
Attitude survey on governance for civil society• The CGCS conducted a large-scale attitude survey (1st NV panel survey) targeting voters inJapan, the US, and South Korea. At the same time, it collected, recorded, and analyzed media
information between the policy elites and the government.
• At the local government level nationwide, the CGCS conducted a large-scale citizen attitude
survey (1st LV panel survey) targeting voters/residents and a large-scale attitude survey (1st LE
panel survey) targeting the policy elites. In addition, the CGCS analyzed election bulletins ofUpper House elections, organized the database of National Diet minutes (Lower House andUpper House) by speaker, digitalized the content of election bulletins and made a database ofthat content, and also a database of the election bulletins of local assembly candidates.
• The CGCS also made it possible to enter new information into the data archive and replaced
server computers.
International collaborations
The CGCS has collaborated with its overseas partners and other educational research centers.
• The CGCS collaborates with the University of California, Berkeley (USA). Young researchers
have gone on internships at the Institute of Governmental Studies for joint research and survey
collection related to research on governance for civil society.
• The CGCS collaborates with Inha University (South Korea). Young researchers specializing ingovernance for civil society were invited to the CGCS to participate in an international
academic exchange conference.
• The CGCS collaborates with Yonsei University (South Korea). An International Symposium
for Young Research Fellows was held in Seoul. The CGCS and Seoul National University(South Korea) held a total of three International Academic Exchange Conferences (with a totalof 46 reports).
• In collaboration with Yonsei University, Seoul National University, and Uppsala University(Sweden), the CGCS held a total of three International Symposia for Young Research Fellows(with a total of 20 reports).
The CGCS will continue to build and strengthen this international network of collaboration.
This Global COE is expected to become an educational and research center for governancerecognized worldwide—a center that trains young researchers to excel.
.
International activities
While giving full play to international collaboration as described above, the CGCS has
disseminated those research achievements in Japan and overseas through the followinginternational activities.
• The CGCS held its 1st International Symposium on Designing Governance for Civil Society.
The Symposium had 77 speakers and 46 research reports all in English. In all, there were 346
participants from Japan and overseas.
• In addition to sponsoring various symposiums and conferences, the CGCS has supported
graduate students and young researchers to give papers in the US, the UK, South Korea,
China, and other countries (for a total of 16 reports).
• Towards becoming a hub of international research discussion related to governance for civilsociety, the CGCS has published the 10th issue of the Journal of Political Science andSociology (available at 210 universities in Japan and overseas), a refereed journal with articles
written mainly in English.
The achievements of the joint research activities between this Global COE and researchcollaborators in Japan and overseas are currently being prepared for publication as acompilation of monographs in English.

Special Coordination Fund for the Promotion of Science and Technology, [Developing Models for Supporting Woman Researchers] FY2008

Project for Developing Social Capital and a Good Working Environment for Women Researchers
Project Leader: Kaeko Yamashita (Director of Work-Life Balance Research Center andProfessor of Faculty of Nursing and Medical Care) http://www.wlb.keio.ac.jp/
By providing women researchers with a way to reconcile research with life events—suchas childbirth and child-rearing—and by conceptualizing, planning, and implementing aseries of support measures to enable women to continue a career as a researcher, the“Project for Developing Social Capital and a Good Working Environment for Women
Researchers” aims to build a campus environment infrastructure that enables thecontinuation of research and education activities.
One feature of this Project is the effort under way to create a new movement with
university-wide cooperation through the maximum utilization of social capital built up over
the years.
Centered on the “Work-Life Balance Research Center” established in February 2008, theProject has implemented support measures in the following four categories.
1. Development of promotion organization
In March 2009, the “Office for Promotion of Gender Equality” was established toadvance not only childbirth and child-rearing support, but various other needs
university-wide such as home-care support. To enable women researchers to continue
research activities under any circumstances, the “Research Support Program” wasimplemented to hire research assistants. These programs contributed, for instance, to four
presentations at international conferences. In addition, an information support
environment—making use of information and communication technology—has beendeveloped and includes a web-conferencing system.

* The general director of this project is the president of Keio University.

broaden their human network. In February 2009, the first symposium on “Support for
Women Researchers and Promotion of Gender Equality at Keio” was held to draw
attention inside and outside Keio to the efforts underway at the Center.
4. Promotion of investigation and research
The Center has conducted a survey on work-life balance and promotion of genderequality among full-time academic staff at Keio University. This survey shed light on
specific problems and needs related to child rearing, home-care, and other life
balance areas. The survey results were published on the Center’s website. Goingforward, the Center will effectively utilize the knowledge gained through these efforts to
explore policies that will contribute to gender equality across all campuses.
AlumniCounselor

Middle school andhigh school students･Set up counseling liaison･Career advice service
arrangement

3. Empowerment support
Support needs are diverse. In FY2008, the campus working-groups held five
workshops at the campuses so that researchers could exchange information and･Providing role models･Rousing the interest ofresearchers
Information support

Investigation of needs
Promotion of research

Women researchers withchild-rearing experience

Promotion of research
related to work-life balance

2. Childcare support
A “childcare supporter training program” was launched to provide temporary andflexible childcare support using on-campus facilities. A total of 15 students havesigned up after receiving a certificate of childcare support supervised by the Center. The
Center and NPO Florence have begun joint development of a sick child care service foruniversity and research organizations. A trial service was launched from December
2008. In addition, a database of childcare and local resources has been created and an
information service has been launched.

Support for career development

Nextgeneration
training
support

Women researchers
currently rearing children

Office for Promotion of
Gender Equality
Development of IT environment/
facilities

Childcare
Sick childCounselingCollecting information of
local resources in a database

Local collaboration
Women researchers
preparing to rear children

Development of
employment system

Childcare support
Student andlocal volunteers

Graduate students
Networking support

Domestic/
international collaboration

Lectures, symposiums
Support work by researchers
taking time off or working shorter
hours due to child rearing

Trained staff provide
childcare support

Support for forming a community of women researchers

Global COE Program / Special Coordination Fund for the Promotion of Science and Technology

34

Special Coordination Fund for the Promotion of Science and Technology [Improvement of research environment for young researchers] FY2008

Career development program for young investigators in "Cell and Metabolism Research"(Keio-Kanrinmaru Project)* The university president has overall authority over this project
Project Leader: Toshio Suda (Professor, School of Medicine) http://www.careerpath-prj.keio.ac.jp/kanrinmaru/english/
This project is funded by the Ministry of Education, Culture, Sports, Science and Technology(MEXT). Its aim is to introduce a tenure track program into Keio university by fostering the next
generation of leaders in the basic research of cells and metabolism.
This year, we selected gifted young researchers from all over the world, and in most cases weoffered them employment until 2012. By breaking new ground in the creative research of cells andmetabolism, we will pave the way towards offering tenure to young researchers who have thecapacity to become widely acknowledges as leaders in the field.
We will perform annual performance assessments and mid-term interim assessments, and we will
perform tenure reviews based on clear standardized evaluation criteria at the end of thisperiod.
In this way, we intend to carry out a tenure system and evaluation systems for teaching staff, partly
introduced into the School of Medicine.
The university president has overall authority over this project, which is managed by a tenure tracksteering committee as a university-wide organization covering all schools, comprising teaching staff
from related faculties situated in KARC Career Development Center. The steering committee is led
by Professor Toshio Suda of the School of Medicine.
In this first year of the project, we launched an international appeal for tenure track teaching staff,
we screened the applications (the application documents were all prepared in English) andconducted interviews in English. Out of 98 applicants (of whom 21% were female researchers and
11% were from overseas), we employed 3 researchers as associate professors (non-tenured), anda further 10 as assistant professors (non-tenured). In the selection process, the selection
committee (including committee members from outside the university) paid particular attention not
only to details such as the content of the research proposals, the performance records of theresearchers and their record in acquiring competitive research funding, but also to qualities
that marked individuals out as young researchers capable of bringing in new techniques andconcepts rather than adhering to established research models, and researchers who are not simply
a cut above the rest but true leaders in their respective fields of research.
We are actively supporting the 13 successful candidates in their research activities, and we havejust about finished setting up their research environments in line with our basic policies ofproviding targeted research funding and providing personal and material support for existing related
laboratories.
Furthermore, we have prepared shared research facilities to promote the formation of anenvironment where independently-minded researchers can effectively pursue their own

studies.
Tenure track teaching staff budgetary allocations, etc.
Associate Professor (Non-tenured)•Start-up fund of ¥20 million, followed by research funding of ¥3 million for each subsequent year
•Salary payments based on university salary scheme•Exclusive use of approximately 100 m2 lab space•Ability to hire one research assistant (postdoctoral student or technical staff)
Assistant Professor (Non-tenured)•Start-up fund of ¥10 million, followed by research funding of ¥2 million for each subsequent year
•Salary payments based on university salary scheme•Lab space provided in the university laboratories
Successful tenure track applicants (random order)
Name

Research theme

Takeshi Miyamoto

Regulation of Bone Homeostasis by Osteoclast cell-cell Fusion and Aging

Associate Professor (Non-tenured)

Shinji Makino
Associate Professor (Non-tenured)

Cardiomyocyte niche for cardiac regeneration:
Toward an understanding the mechanisms underlying cardiomyocyte proliferation and maintenanceTakashi Kobayashi

Molecular basis for inflammation by mouse genetic engineering and bioimaging

Associate Professor (Non-tenured)

Giichi Takaesu

Physiological and pathological roles of autophagy in mammals and its regulatory mechanisms.

Assistant Professor (Non-tenured)

Akiharu Kubo

Molecular “Barriology” of the Skin ~Unlock the Puzzle of Skin Barrier and Allergic Diseases~

Assistant Professor (Non-tenured)

Yohei Okada

The analysis of the development of human neural stem/progenitor cells using human ES cells and human iPS cells

Assistant Professor (Non-tenured)

Shinsuke Yuasa

Direct reprogramming of somatic cells to cardiac myocytes

Assistant Professor (Non-tenured)

Yoshiaki Kubota

Development of novel tumor-selective anti-angiogenic therapy

Assistant Professor (Non-tenured)

Jin Nakahara

Translational research for the development of central nervous system remyelination medicine

Assistant Professor (Non-tenured)

Shinichiro Nakada

The impact of inaccurate DNA damage response on stem cell maintenance, tumorigenesis and senescence.

Assistant Professor (Non-tenured)

Itsuki Ajioka

Epigenetic Role of Rb during Rod Photoreceptor Differentiation

Assistant Professor (Non-tenured)

Keisuke Horiuchi

Functional analysis of ectodomain shedding by TACE (TNF converting enzyme, ADAM17)

Assistant Professor (Non-tenured)

Tsukasa Oikawa

Metabolome/transcriptome analysis of the EMT process for the regulation of cancer cell plasticity

Assistant Professor (Non-tenured)Special Coordination Fund for the Promotion of Science and Technology [Encouraging innovative and creative young researchers] FY2008

Medical Biologist Support (MEBIOS) Training Program
Project Leader: Koichi Matsuo (Associate professor, School of Medicine)
http://www.keio-mebios.com/index.html
MEBIOS (Medical Biologist Support)
This project aims to support young socially responsible PhD students who are able torespond to society’s needs in a broad range of fields centered around medical
science, including technology and information science.
We have provided practical programs such as holding open seminars and otherprofessional training courses, and providing internships of at least 3 months by linking up
with businesses and research organizations both in Japan and overseas. These aretargeted at postdoctoral and Ph.D. students who have qualified for selection within thelast five years.
The mission of academia is to allow society to benefit from Ph.D. holders who mayachieve outstanding research results but have little opportunity to interact withorganizations in the real world such as businesses. At the MEBIOS project, mentors withbusiness experience are designing flexible and detailed programs suited to individual
researchers. This project is working its way into the graduate schools of medicine,science and technology, media and governance, and pharmaceutical sciences.
Activities in the 2008 academic year
•Setting up the MEBIOS steering committee and MEBIOS office
As the decision-making body of this program, the MEBIOS steering committee wasassembled from teaching staff of various related faculties (chairperson: Professor
Koichi Matsuo, School of Medicine). Since July, coordinators and mentors with athorough knowledge of the business world have been brought in to the MEBIOS officewhere the program is planned and administered (Shinanomachi Campus, Integrated
Medical Research Building, 2nd Floor).
•Selected MEBIOS candidates and MEBIOS members
Ph.D. students that pass selection are hired by the university for between threemonths and one year, and participate in a program of practical experience.In the earlystages, students that are still planning their academic careers are also offeredconsultations as MEBIOS members. Since this was the first year of the project, we started
by selecting 11 postdoctoral researchers, of whom three have commenced
employment. We also enrolled 33 MEBIOS members.
•MEBIOS corporate members
As places that will accept internship placements, we have entered into cooperative
contracts with businesses and research organizations operating in fields as diverse as drug

35 Special Coordination Fund for the Promotion of Science and Technology* The university president has overall authority over this project

manufacture, drug discovery, instrumentation
manufacture, clinical testing, communications,image processing and publishing. A growing
number of member businesses support the aims of this program, and we are also
setting up links with new businesses to respond to the demands of researchers taking partin the program.
•Practical program
Internship: By getting involved in joint studies with businesses in the School of
Medicine Research Park and with businesses and other organizations in Japan andoverseas, the candidates perform on-site training for a total of at least three months in
research and development and other duties. This year’s three candidates performedinternships at two biotech companies and at a 3D image analysis company. One of themcompleted the program and was employed by the company’s research laboratories.
Professional coaching: We also hold courses and open seminars to impartknowledge from diverse specialized fields. This year we held well-attended courses on
the basics of intellectual property, a scientific communication course, clinical researchbasics, and a basic course in career design.
Mentoring system: By inviting experienced business executives to act as mentors, wewere able to provide young researchers with individual guidance in regular individual
consultations.
•Progress report meetings
At the end of the academic year we held a progress report meeting where theachievements of the candidates were announced. By conducting lectures and panel
discussions with business human resource executives and Ph.D. holders working inindustry, a wide range of opinions
were exchanged regarding the sortof Ph.D. students that businesses
actually need.

Professional coachingCore Research for Evolutional Science and Technology CREST FY2008

Creation of a highly secure OS with advanced attack protection
Research Representative: Kenji Kono (Associate professor, Faculty of Science and Technology)
http://www.crest-os.jst.go.jp/index.html
As the Internet develops, services that use it are becoming part of the modern social
infrastructure. However, this trend is accompanied by a growing incidence of cases where
personal data is lost as a result of illegal cyber attacks launched over the Internet. Due torapid advances in technologies such as smart phones and consumer electronics, there willsoon be many more devices connected to the Internet. It is therefore becoming increasingly
important to improve the reliability and security of Internet services. In this project, we aim tocreate an operating system (OS) that can withstand the growing onslaught of attacks andviruses. Specifically, we are researching and developing a software platform that uses modern
technological tools such as virtualization technology and security chips to run Internet services moresafely based on a thorough review of the security measures in existing operating systems. We arealso investigating the introduction of a dependable OS (DEOS), which is being researched anddeveloped in all these research areas. DEOS is intended to be used in the open environments suchas the Internet. With the aim of getting this OS implemented in practice, we are holding
frequent meetings with projects at other universities. In 2008 (the first academic year of thisproject), we researched and developed the core technologies available for the construction of a
DEOS safety net using virtualization technology to achieve the aims of this project.
One of our achievements in the 2008 academic year was a keylogger detection system that
employs virtualization technology. A keylogger is a piece of software that detects whenever theuser touches the keyboard. Once a keylogger has been smuggled into a computer, it can be used
to steal private information such as credit card numbers and passwords. Keyloggers are
rapidly evolving, and it is becoming difficult to detect them with conventional antivirus
software. In this project, we have researched and developed a system that can detect this sort of
keylogger. In November 2008, the results of this research were announced at the Xen Summit Asia
2008, which was attended by virtualization technology engineers and researchers from all over theworld.

with conventional techniques. The results of this study were announced at a national
symposium, and the students that made the announcement received a student paper award. After
performing additional research, the results were accepted at the DIMVA 2009 conference
which is held in high regard internationally in the field of system security.
Other R&D subjects include a technique for detecting viruses that use so-called rootkits toconceal their presence inside operating systems, and a technique for operating security
software efficiently in virtual environments. We learnt a lot from the technology weresearched and developed in the 2008 academic year, and in the future we can expect tocontinue researching and developing software technology.
For the 2009 academic year, we havestrengthened our research system. We
have established a research space atthe university’s Shin-Kawasaki Town
Campus, where a complete research
environment has been set up. We havealso increased the project membershipby welcoming a new assistantprofessor, and we have worked towards
establishing links with other universities inthis field. To achieve the project’s aims,
we will continue with our efforts in the2009 academic year.

Keylogger detection system
Kono Laboratory, Keio University
Keylogger threat
Malicious software that records the user’s keypresses
Attacker collects information

PC infected with a keylogger

Keylogger records and transmits keypresses

Keylogger detection system using virtual machine technology
Detects the characteristic behavior of keyloggers
Recorded keypress data recorded to disk or output to the net
Behavior monitoring

Keylogger behavior is monitored on the VM from the VMM

Unknown keyloggers can also be detected
VM monitoring

Makes it difficult to conceal keyloggers

I/O monitoring

Detection system
Recorded keypress data recorded to disk or output to the net
Keylogger behavior is monitored on the VM from the VMM Keyloggers can only operate inside the VM

Approach
Generate mote keypresses than
could be produced manually

Another achievement is the research and development of a system that analyzes malicious
messages sent from Internet servers. In recent years, malicious messages have become harder toanalyze due to the use of self-encryption techniques and the like. In this project, we haveresearched and developed a system that analyzes malicious messages that were difficult to analyze

Look for changes in output to thedisk / network, or in CPU load

Large-scale
keyboard
interrupt

Keylogger

Characteristicchanges in disk /network usage,etc.

VMM + detection system
Monitor CPU load and disk/network accessCore Research for Evolutional Science and Technology CREST FY2008

Analysis of Abnormal Regulation of Cell Differentiation and Drug Development Research by
Using Induced Cancer Stem Cells
Research Representative: Hideyuki Saya (professor, School of Medicine) Collaborator: Hiroshi Yanagawa (professor, Faculty of Science and Technology)
http://www.ipscc.jst.go.jp/english/index.html

Cells that can adapt to form various different types of body tissue are called tissue stem
cells. These cells can not only make copies of themselves (self-replication), but can also
produce cells that differ in various ways using themselves as a starting point(differentiation). By constructing a hierarchy of cell communities with these stem cells at
the top, we can provide a lifetime’s supply of short-lived cells such as blood cells, skincells and mucosal epithelial cells. It is also known that the proliferation and survival ofstem cells are controlled by their extracellular microenvironment (or “niche”). In
recent years, it has been conjectured that hierarchies similar to those of normal
tissues are also present in cancer tissue, which mimic stem cell systems with regard totheir generation and maintenance. The stem cells at the top of these hierarchies are called
cancer stem cells.
The concept of cancer stem cells is important because these are cell fractions that exhibit
resistance to treatment. It was previously thought that statistical probability was the only
factor determining whether or not tumors are left behind after chemotherapy orradiotherapy. However, by introducing the concept of cancer stem cells, it has been shownthat the presence of these residue cells can be explained by biological factors. Based on
this idea, we need to establish treatments that necessarily take cancer stem cells into
consideration. Various new treatment strategies can be considered, such as attacking thecancer stem cells directly, destroying the relationship of the cancer stem cells with thecancer cells in their surrounding microenvironment (niche), or using anticancer drugs toknock out cells as soon as they have turned into precursor cells. To perform
treatments such as these, we need to prepare large numbers of cancer stem cells andconduct investigations using drug screening and animal models.

mechanisms that maintain their properties as cancer stem cells, and so on. It also
sheds light on molecular interactions that were difficult to discover using the
traditional method of excising and analyzing tumors that have grown in vivo.
We will briefly discuss the results of the first academic year that we obtained byusing iCSC. First, we introduced the N-myc cancer gene into hematopoietic stem
cells/precursor cells and performed bone marrow transplantation, whereupon 100% of
the mice developed B-cell lymphomas. We successfully detected cell fractions
resistant to treatment in these tumor cell populations. We found that these resistant cells
behave like cancer stem cells, and are better at forming tumors than the susceptible cells.
We are currently performing a detailed analysis of molecular expression, and we havediscovered that slight differences in cell differentiation work as factors separating
cells that resist treatment from cells that are susceptible to treatment. In other words, it
seems that the discovery of a method for changing the degree of cancer stem celldifferentiation will make it possible to increase the possibilities for treatment if
resistant cells can be transformed into susceptible cells. In the future we hope to use iCSC
to clarify the factors behind non-uniformity in tumor tissue, especially non-uniformity inthe response to treatment, and we hope to develop ways of correcting theseirregularities.

Short time period
It is known that induced pluripotent stem cells (iPS cells) can be made to appear bymanipulating a limited number of genes in order to reprogram differentiated cells.
Based on this technique, we performed limited gene manipulation in undifferentiatedmyelopoietic cells, bone marrow mesenchymal cells and nerve cells of adult mice, andsucceeded in producing induced cancer stem cells (iCSC) with perpetual selfreplicating potential that could form malignant tumors quickly and in roughly the same
period of time in all the mice into which these cells were transplanted. Using iCSC, it ispossible to perform in vitro observations of the process whereby normal cells turn into
cancer stem cells, the conditions needed for this to happen, the molecular

ICSC

Differentiation
potential

High frequency
Normal mouse cellSelf-replication

Producing induced cancer stem cells: By subjecting normal cells to limited genetic manipulations,
we can induce cancer stem cells with the ability to self-replicate and differentiate frequently in a shortperiod of time without encountering hyperplasia or genetic instability periods.

Core Research for Evolutional Science and Technology

36

Ministry of Education, Culture, Sports, Science and Technology (MEXT) Grant-in-Aid for Scientific Research / Grant-in-Aid for Creative Scientific Research FY2008

Activation and neurogenesis of adult neural stem cells
Research Representative: Hideyuki Okano (Professor, School of Medicine) http://www.okano-lab.com/en/
It has been shown that neural stem cells are present in the adult mammalian brains, where they
actively generate neurons. We have taken on the challenge of developing neural regeneration
treatments based on the approach of using these newly formed neurons to replenish neurons thathave been lost by concussion or neural disease.
To make it possible to generate neurons freely from neural stem cells, we first have to gain athorough understanding the underlying molecular mechanism of how neural stem cells todifferentiate into neurons. We can only do this if we have some way of accurately identifying
neural stem cells and neurons.
Immunostaining is a widely used technique for distinguishing different cell types. It works by using
antibodies that target marker proteins specific to each of the cell types to be distinguished.
However, the immunostaining process often causes significant cell damage, and can impair
the quality of RNA that is used as a material for analyzing the state of gene expression. As analternative to immunostaining, we have investigated a transgenic mouse system for visualizing
neural differentiation by combining mouse genetics with fluorescent proteins that have been
expanded in recent years to a repertoire that fully covers the visible light region. In thissystem, as neural stem cells differentiate into neurons, the fluorescence emitted by these cellschanges color. This makes it possible to figure out in real time the stage of neural celldifferentiation based on the fluorescence color.
As one of the main components of this mouse system (called “Color Timer”). We haveproduced a transgenic mouse in which the production of Kusabira-Orange (KO) fluorescentprotein is controlled by the control region of *nestin* genes that are activated in neural stem cells(nestin/KO Tg mouse). In the adult brain of this mouse, cells emitting strong orange
fluorescence were identified in two regions where new neuronal cells are generated— thehippocampal dentate gyrus, and the subventricular zone of the lateral ventricles. We also
confirmed that most of these orange cells are nestin-positive, and that cells recovered by a cell
sorter using orange fluorescence as an indicator exhibited the properties of neural stem cells.
Furthermore, by crossing this nestin/KO Tg mouse with a DCX-EGFP Tg mouse that emits green
fluorescence from immature neurons, we obtained a double Tg mouse in which it was possible toobserve the differentiation of orange neural stem cells into green immature neurons. This
“Color Timer” mouse system is expected to become a powerful new tool for clarifying neural celldifferentiation mechanisms.

Ministry of Education, Culture, Sports, Science and Technology (MEXT) Grant-in-Aid for Scientific Research / Grant-in-Aid for Creative Scientific Research FY2008

Pursuit of Substances in Dynamic Ecological Systems
Research Representative: Daisuke Uemura (Professor, Faculty of Science and Technology) http://www.bio.keio.ac.jp/labs/uemura/gakujutu/results.html
The discovery of new molecules with novel structures often triggers the development of basic
scientific concepts. By searching for molecules focusing on the dynamic ecological systems, we
aim to create new fields of biomolecular science by serving important compounds impacting life
sciences. All new compounds which we found were subjected to various bioassays and thenpublished in papers. After that, we attempted to promote their application and to make acontribution to the related other fields. In the last year we obtained the following results:
1. Compounds related to symbiotic and parasitic phenomena
We isolated a novel macrolide, luminaolide, that induces settlement and metamorphosis inhermatypic coral larvae. It is hoped that this finding will contribute directly to theenvironmental conservation of coral reefs.
2. Compound exploration focusing on food chain dynamism and compound function
We determined the stereo structure of symbiodinolide, which is a super-carbon-chain
compound (SCC) with a molecular weight of 2,859 obtained from a dinoflagellate, throughdegradation reactions and synthesis. Symbiodinolide was found to exhibit anti-HIV activity andacute toxicity to mice. Interestingly, symbiodinolide caused flatworms, the host animals, toexcrete symbiotic algae. Thus, it was suggested that symbiodinolide acts as a chemicalcommunication molecule between the host and symbiotic organisms. In addition, we
discovered a new chemical degradation reaction. This selective degradation reaction may be widelyused in the future as an essential technique for determining the structure of SCC. Fromdinoflagellates, we also discovered symbiospirol A (PKC inhibitor and anti-inflammatory
substance) and symbiopolyol (VCAM-1 inhibitor), and we successfully isolated the most hugemarine natural product with the molecular weight of 5,148.
As a new method for analyzing the shape of SCC in solutions, we investigated the use ofsynchrotron radiation X-ray small angle scattering (SAXS) at the SPring-8 facility, and weshowed that the horseshoe-like shape as a dimer of palytoxin has an important bearing on theexpression of palytoxin activity. This result constitutes an important milestone in the chemical
analysis of natural substances using SAXS.
3. Paralytic molecules originating from terrestrial animal, and clarification of theirfunctions
In collaboration with the University of New South Wales and Taronga zoo in Australia, we
obtained fresh venom samples of duck-billed platypus, and successfully isolated theconstituent that exhibits kallikrein-like protease activity and Ca2+ influx in human neuroblasts. Using
MS/MS analysis, we discovered six new peptides corresponding to the pre-sequence and Nterminus of C-type natriuretic peptide (CNP). Since there have been no mammalian Ca2+
channel agonists reported to date, it is expected that this discovery will lead to thedevelopment of new anesthetics and analgesics. Another mammalian toxin source is theshort-tailed shrew (Blarina), whose submandibular gland containing a fatally toxic protein
called blarina toxin (BLTX). In addition to this finding, we could resolve the long-standing
question of the mammalian toxins. We have also revealed that a paralytic molecule derived fromthe hunter wasp was a protein similar to arginine kinase.
4. Comprehensive evaluation of biological activities
By linking up with co-researchers and contract research companies in Japan and overseas, we haveevaluated the biological activities of various compounds that we have acquired. In addition to thecompounds mentioned above, we have discovered novel PKC activator complanine, derived
from Chloeia flava, and the novel anti-tumor compound, halichonine C, derived from
Halichondria okadai.

Ministry of Education, Culture, Sports, Science and Technology (MEXT) Grant-in-Aid for Scientific Research / Grant-in-Aid for Creative Scientific Research FY2008

Discovery of gas-responsive regulatory mechanisms in biological systems:
Multidisciplinary approaches and their application to medicine
Research Representative: Makoto Suematsu (Professor, School of Medicine) http://www.gasbiology.com/home/english/index.html
In the 2008 academic year we made great progress in mining novel gas receptor systems by using
metabolome analysis technology. We also used nano-bead technology to perform systematic
exploration of macro molecules with gas accepting capacity. As a result, we found that heme isable to bind reversibly to the rate-determining enzyme of major metabolic pathways that do notpossess heme binding motifs, and that there are many co-sensing molecules that regulate
metabolic systems as a whole. CO gas is produced by stress-inducible heme oxygenase-1 (HO-1),
an enzyme that produces CO in various cells under stress conditions. The first techniques for thesystematic investigation of gas receptor proteins have not only been established, but thecharacteristics of gas molecules have also been clarified by showing that very slight structuraldifferences triggered by the gas binding can cause dramatic changes in macromolecularfunction. In a recent study, an investigation using metabolome analysis identified
cystathionine -synthase (CBS) as a new receptor for stress-induced CO gas, demonstrating thatthe gas controls metabolic systems by means of multicentric suppression for different
metabolic pathways.

On the other hand, the structural enzyme heme oxygenase-2 (HO-2) that produces CO isregarded as an intriguing oxygen sensor because when the concentration of molecular oxygen (thesubstrate) decreases, the generation of CO undergoes a corresponding decrease. The brain
produces large quantities of CO. Our findings have shown that in the cerebellum where HO-2 andCBS are expressed abundantly, the neurons become CO generation sources. Meanwhile theastrocytes express co-inhibitable CBS, suggesting that the generation of H2S generated by thisenzyme is suppressed. It has been shown that CO is a gas mediator that regulates
microvascular tone of the brain by controlling the metabolism of local neurovascular units. We are
currently examining a hypothesis that hypoxic vasodilation is operated by neuronal CO (HO-2) andastrocyte CBS to control local blood flow.

37 Ministry of Education, Culture, Sports, Science and Technology (MEXT) Grant-in-Aid for Scientific Research / Grant-in-Aid for Creative Scientific ResearchResearch Funds at Keio University in FY2008
Research funds at Keio University from national and local public institutions, private businesses, and university funding totaled approximately ¥17.2 billion
in FY2008.
The charts below show research fund totals classified in various ways, such as by type of fund, by type of external entity making the contribution, by
campus, by researcher affiliation, by research field.

1. Research Funds by Type
When classifying by type of research funds,
specified contributions account for the largest
number of projects and subsidies account for thelargest amount in yen.
University funds represent less than 5% of
the total at 800 million yen. Research funds
from external entities represent nearly 95% of
the total at 16.4 billion yen.
*The total for university funds includes a contribution
from the Current Expense Subsidies for Private
Universities.
•Special expenses for graduate school education andadvanced graduate school support menu group•Local contribution support menu and regional joint
research support as knowledge bases•Improvement project for high technology research
center/Science frontier program/Community
collaboration program/Improvement project for open
research center•Creation and support of a base for strategic researchat private universities

Research Funding Share by Type
(Amount (outer ring), Number of Projects (inner ring))
Joint Research

9.7%

4.5%

Joint Research

8.5%

10.7%
Commissioned
Research

Subsidies

33.4%

Specified
Contributions

2.0%

878

6,910,061

Grants1.0%

Commissioned Research

389

5,762,275

Joint Research

351

1,466,307

1

290

Contracts
Technical Guidance
Total

3

1,702

3,631

17,232,222

Specified
Contributions

Technical
Guidance

Commissioned Research:
Research commissioned by government andother public offices, as well as private
enterprises.

Grants

Subsidies

166,903

Contracts

Specified Contributions:Contributions earmarked for research activities.

781,824

2,142,860

GrantsGrants:Research expenses provided mainly byfoundations for the purpose of improvement or
accomplishment of research.

40.1

32.7%

749

71

Subsidies%

24.2%

Specified
Contributions

University Funds

1,189

Joint
Research

Subsidies:
Research funds provided mainly by government
and their public offices.

20.6

AmountSpecified Contributions

Subsidies

Definition

University Funds%

Commissioned
Research

Number of Projects

GrantsCommissioned
Research

University Funds

Thousand yenType of Funds

University
Funds

12.4%

Joint Research:
Collaborative research through personnel
exchanges and/or sharing technology/facilities
under the joint research agreement, with orwithout payment of research funds.
Contracts:
Research under a contract agreement.
Technical Guidance:
Research involving technical guidance such as
development of equipment or apparatus.

2. Type of External Entity Contributing Research Funds
This category classifies funds by the type of
external entity making the contribution.
Private corporation account for the largest
number of projects while the government
account for the largest amount in yen.
*This chart represents the total number of projects andamount in yen excluding the "University Funds" item in"1. Research Funds by Type."

Government

Nonprofit Foundation,
Charitable Organization

Local Public
EntityForeign Country

Independent
Administrative Agency,
Semi-Governmental
Corporation

Private Individual

PrivateCorporation

Other

Foreign Country

0.5%
Nonprofit Foundation,
Charitable Organization

1.9%

Private Individual

1.8%

Foreign Country

0.6%

Other University

Thousand yen
Number of Projects

AmountGovernment

928

8,896,665

Local Public Entity

15

721,198

Independent Administrative Agency, Semi-Governmental Corporation

147

2,206,746

Private Corporation

1,386

3,895,420

Other University

10

7,776

Type of External Entity

Contribution Share by External Entity Type
Amount (outer ring), Number of Projects (inner ring))

Nonprofit Foundation,
Charitable Organization%

7.3

Private Individual%

Government%
Government%

5.5

Private Corporation

23.7%

32.2

Private Corporation

48.1%

Nonprofit Foundation, Charitable Organization

211

314,203

Foreign Country

17

83,570Independent Administrative Agency,
Semi-Governmental Corporation

Private Individual

13.4%

159

297,154

Other

927,666

Total

2,882

16,450,398

54.1

Local Public Entity

Local Public Entity
%

4.4

0.5%

Independent Administrative Agency,
Semi-Governmental Corporation

5.1%

Research Funds at Keio University in FY2008

38

Commissioned Research Expenses by External Entity Type

Commissioned Research Expenses by External Entity Type
(Amount (outer ring), Number of Projects (inner ring))

Thousand yen

Number of Projects

AmountGovernment

61

2,828,470

Local Public Entity

9

16,093

Type of External Entity

Independent Administrative Agency, Semi-Governmental Corporation

110

2,023,287

Private Corporation

175

780,889 Other University

Other University

1800

Nonprofit Foundation, Charitable Organization

21

43,320Foreign Country

7

46,816Other

522,600Total

389

5,762,275

0.3%

Other

Other University

Other

Nonprofit Foundation,
Charitable Organization

Local Public Entity

Private Corporation

2.3%

13.6%

Foreign Country

Government
%

15.7

Other

Government

49.0%

Foreign Country
Independent Administrative Agency,
Semi-Governmental Corporation

1.8%

Independent Administrative Agency,
Semi-Governmental Corporation

28.3%

35.1%

Private Individual Other%%
Foreign Country
Government%
Independent%
Nonprofit Foundation,
Administrative Agency,
Local Public Entity Semi-Governmental
Charitable Organization
Corporation
Other University%%%%
Private Individual
Government%% Local Public Entity
Foreign Country
Nonprofit%%
Foundation,
Charitable
Organization
Independent Administrative
Agency, Semi-Governmental%
Corporation
Other University
%
%
Other
%

0.7

PrivateCorporation

1.3%

Joint Research Expenses by External Entity Type
(Amount (outer ring), Number of Projects (inner ring))

0.3

Independent
Administrative Agency,
Semi-Governmental
Corporation

0.4

5.4%

45.0

0.7

Foreign Country

0.8%

Nonprofit Foundation,
Charitable Organization

PrivateCorporation%

0.1

Local Public
EntityNonprofit Foundation,
Charitable Organization

0.8%

Government

0.2

0.1
0.4

4.6

0.6

1.4

Local Public Entity

0.3%

2.3

1.4

Independent
Administrative Agency,
Semi-Governmental
Corporation

6.0

PrivateCorporation

0.9

Other University

Private Corporation

80.6%
95.2%

AmountGovernment

2945

Local Public Entity

5

5,105

Independent Administrative Agency, Semi-Governmental Corporation

21

34,206

Private Corporation

283

1,396,576

Other University

6

5,000

Nonprofit Foundation,
Charitable Organization

Nonprofit Foundation, Charitable Organization

10

9,992

Foreign Country

Foreign Country

5

9,849

Private Individual

16

1,568

Other

3

3,066

Total

351

1,466,307

Private Individual

Private Corporation

Thousand yen

Number of Projects

Type of External Entity

Local Public
Entity2.8

1.7

Joint Research Expenses by External Entity Type

Government

Other

3. Research Funds by Campus
At Keio University, each campus has an Office of
Research Administration that manages research funds.
Classifying research funds by campus shows that
Shinanomachi Campus (home of School/Graduate
School of Medicine) accounts for the largest number ofprojects and the largest amount in yen, followed inboth categories by the Yagami Campus (home of theFaculty/Graduate School of Science and Technology).
*The totals are compiled based on the home campus (in principle, theaffiliation of the research project representative). However, theactual research may take place at a different campus.
Thousand yen
CampusResearch Funding Share by Campu(Amount (outer ring), Number of Projects (inner ring))

Hiyoshi Campus

Tsuruoka Town
Campus%Shin-Kawasaki Town Campus

5.5

Tsuruoka Town Campus

0.6%

1.8%

1.2

14.1%

326

2,439,417

Hiyoshi Campus

247

326,532

Yagami Campus

746

3,439,139

Shinanomachi Campus

1,795

7,761,599

Shonan Fujisawa Campus

444

1,815,564

Shiba-Kyoritsu Campus

49

198,543

Shinanomachi Campus

Shin-Kawasaki Town Campus

2

310,30449.4%

22941,124
17,232,222

1.9

10.5

Hiyoshi Campus

6.8%

12.2

Yagami Campus
Mita Campus

9.0%

20.5%

Shinanomachi Campus%

45.0

39 Research Funds at Keio University in FY2008

Hiyoshi Campus%

Shonan Fujisawa
CampusShonan Fujisawa%
Campus%Mita Campus

3,631

Shiba-Kyoritsu Campus

Mita Campus

1.4%

AmountTotal

Shinanomachi Campus
Shonan Fujisawa Campus

Number of Projects

Tsuruoka Town Campus

Yagami Campus

0.1%

Shin-Kawasaki
Town Campus
Shiba-Kyoritsu
CampusShiba-Kyoritsu%
CampusMita Campus

Yagami Campus

20.0%

Shin-Kawasaki Town Campu
Tsuruoka Town Campus

4. Research Funds by Affiliation of
Researchers
Classifying funds by affiliation of researcher (inprinciple, the research representative) shows that the
School/Graduate School of Medicine accounts for thelargest number of projects and amount in yen, followed by
the Faculty/Graduate School of Science andTechnology.

Research Funds by Researcher Affiliation (in order of amount)
Thousand yen
8,000,000

Affiliation of Researcher

Number of Projects

AmountFaculty/Graduate School of Letters

128

644,685

Faculty/Graduate School of Economics

108

444,658

Faculty/Graduate School of Law

74

421,959

Faculty/Graduate School of Business and Commerce

79

156,961

School/Graduate School of Medicine

1,799

7,699,194

Faculty/Graduate School of Science and Technology

757

3,431,855

Faculty of Policy Management

160

325,597

Faculty of Environment and Information Studies

224

2,106,073

Faculty of Nursing and Medical Care

33

102,615

Faculty of Pharmacy

49

198,543

Graduate School of Human Relations

3

7,950

Graduate School of Media and Governance47

166,076

Graduate School of Health Management

1

1,000

Graduate School of Business Administration

24

24,644

Graduate School of System Design and Management31

367,489

Graduate School of Media Design25

125,265

Keio Law School

32

28,880Research Institutes

56

976,778

Others

1

2,000

Total

3,631

17,232,222

7,000,000

6,000,000

5,000,000

4,000,000

3,000,000

2,000,000

1,000,000

Fa
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0

5. Research Funds by Field
Classifying research funds by field shows that medical
science accounts for the largest number of projects
and the largest amount in yen. The field classifications
were derived from the MIC (Ministry of Internal Affairs
and Communications) Survey of Research andDevelopment and research expense surveys by theJapan Association of Private Colleges and Universities.

Research Funding Share by Field(Amount (outer ring), Number of Projects (inner ring))

Social Sciences

Others0.2%

Science and Technology

Humanities%

6.8

Medical Science

Humanities

Others4.8%

2.0%
Combined

Thousand yen

Humanities

10.4%

Combined
OthersSocial Sciences

7.1%

Definition
Research Field

Number of Projects

AmountHumanities

245

821,011Social Sciences

293

1,216,533

Science and Technology

970

5,161,007

Medical Science

1,894

7,898,727

Combined

220

1,792,828

Others9342,116

Total

3,631

17,232,222

Combined%

6.1

Social Sciences%

Humanities:
History, Philosophy, Literature, Languages, and otherhumanities.

8.0

Science and Science andTechnology Technology
%
%

26.7

Medical Science%

52.2

Medical Science

45.8%

29.9

Social Sciences:
Economics, Sociology, Business and Commerce, Political
Science, Law, and other social sciences.
Science and Technology:
Applied Chemistry, Chemistry, Mechanics andShipbuilding, Engineering, Mathematics, Electrics,
Communications, Physics, and other science andtechnology.
Medical Science:
Medicine, Nursing, Pharmaceutical Science, and other
health and medical sciences.
Combined:
Interdisciplinary fields.

Research Funds at Keio University in FY2008

40

6. Research Fund Data over
Past 5 Years

Research Funds by Type over Past 5 Years
Thousand yen

The table shows that research funding over the past
five years (FY2004 to FY2008) has been increasing.
Looking at research funds by type reveals a sharp
increase in commissioned research projects.

Type of Research Funds

FY 2005

FY 2004

FY 2006

FY 2008

FY 2007

University Funds

416,014798,164

749,592

630,666

781,824

Subsidies

6,186,984

6,436,472

6,387,754

6,317,761

6,910,061

Grants131,297

171,421104,794

134,381

166,903

Specified Contributions

1,704,757

1,604,521

2,063,242

2,194,895

2,142,860

Commissioned Research

4,926,284

4,296,684

4,438,734

5,424,980

5,762,275

Joint Research

355,713

1,163,996

2,073,601

1,742,299

1,466,307

Contracts

164,248

88,49959,403

1,995

290

150

6,745

0

1,300

1,702

13,885,447

14,566,502

15,877,120

16,448,277

17,232,222

Technical Guidance
Total

University Funds
Subsidies

13,885,447

FY2004

GrantsSpecified Contributions
Commissioned Research

FY2005

14,566,502

Joint ResearchContracts
Technical Guidance

15,877,120

FY2006

FY2007

16,448,277

FY2008

00

00

00
,0
20

,0
15

00

,0

,0

00
,0
10

5,

00

00

0,

,0

00

0

0

17,232,222

Direct Research Expenses, Indirect Research Expenses, andGeneral Administrative Expenses over the Past 5 Years
Type of Research Funds

Thousand yen

FY 2004

FY 2005

FY 2006

FY 2007

FY 2008

12,754,240

13,137,388

14,142,780

14,467,728

14,563,048

Indirect Expenses

321,228

529,791

781,735

1,305,746

1,873,112

General Administrative Expenses

809,979

899,323

952,605

674,803

796,062

13,885,447

14,566,502

15,877,120

16,448,277

17,232,222

Direct Expenses (Direct Costs)

Total

Direct Expenses (Direct Costs)
Indirect Expenses

13,855,447

FY2004General Administrative Expenses

14,566,502

FY2005

15,877,120

FY2006

16,448,277

FY2007

17,232,222

41 Research Funds at Keio University in FY2008

00

00

,0
00
,0
20

,0
15

00

,0

00
00
,0
10

5,

00

0,

,0

00

0

0

FY2008

Researchers at Keio University in FY2008
This section presents data from FY2008 on researchers involved in research and education at Keio University (professors, associate professors, assistantprofessors and instructors), doctoral students and awardees of doctor's degrees, and researchers participating in research projects at Keio University but not affiliatedunder the any of above conditions.

1 Number of Researchers"Tenured researchers" are those employed under full-time contracts without fixed terms. "Researchers with fixed period contract" are either full-time or part-time. Of those with fixed
period contracts, "special research professors" are paid by research funds allocated from outside Keio University as a condition of appointment.
"Researchers" in the following data only include researchers in the University (Professors, Associate Professors, Assistant Professors and Instructors) and excludes teachers at affiliatedelementary and secondary schools of Keio University. The number of the non-tenured researchers (that is, the total number of researchers with fixed period contracts and special researchprofessors) accounts for 24% overall, but is a striking 45% at Shonan Fujisawa Campus.
Number of people

CampusTenured Researchers

Researchers with Fixed Period Contract

Special Research Professors

0TotalMita

00000,374

00000000000036

00000000040

0,450

Hiyoshi

00000,311

00000000000023

00000000005

0,339

Yagami

00000,238

00000000000024

00000000029

0,291

Shinanomachi

00000,493

00000000000008

00000000220

0,721

Shonan Fujisawa

00000,12900000000000043

00000000 64

0,236

Shiba-Kyoritsu

00000,062

00000000000002

00000000 90

0,064

Total

00001,607

00000000000136

00000000358

2,101

As of 1 May 2008

2 Support for Future Researchers
There are two types of doctor's degrees: course and dissertation doctorates. Course doctorates are conferred upon completion of course work with all other requirements.
Dissertation doctorates are conferred on those who have submitted a dissertation with consent of a committee of a graduate school, and passed the examination by a board of review.
The standard period for completion of a doctoral course is three years, except for the Graduate School of Medicine, which maintains a four year standard.

Number of Doctorates Awarded

Number of Students Registered in Doctoral Courses
Number of people

Number of people

Course Doctorate
Graduate School of Letters
Graduate School of Economics
Graduate School of Law
Graduate School of Human Relations
Graduate School of Business and Commerce
Graduate School of Medicine
Graduate School of Science and Technology
Graduate School of Business Administration
Graduate School of Media and Governance
Graduate School of Pharmaceutical Sciences
Subtotal

007
007
016
010
009
046
097
004
028
4
218

Dissertation Doctorate
Graduate School of Letters
Graduate School of Economics
Graduate School of Law
Graduate School of Human Relations
Graduate School of Business and Commerce
Graduate School of Medicine
Graduate School of Science and Technology
Graduate School of Business Administration
Graduate School of Media and Governance
Graduate School of Pharmaceutical Sciences
Subtotal
Total

014
003
002
001
003
062
014
000
001
81
181
299

Graduate School of Letters〈045〉

Graduate School of Economics〈015〉

Graduate School of Law〈030〉

Graduate School of Human Relations〈011〉

Graduate School of Business and Commerce〈020〉

Graduate School of Medicine *〈068〉

Graduate School of Science and Technology〈150〉

Graduate School of Business Administration〈008〉

Graduate School of Media and Governance〈050〉

Graduate School of Health Management〈010〉

Graduate School of System Design and Managemen〈011〉

Graduate School of Media Design〈010〉

Graduate School of Pharmaceutical Sciences

〈006〉

Total

〈050〉

0,124
0,047
0,182
0,054
0,045
0,220
0,333
0,013
0,164
0,118
0,124
0,115
0,132
1,171

As of 1 May 2008
Figures in parentheses indicate the maximum number of entrants for the graduate school.
*The figure for the Graduate School of Medicine refers to the number of students registered in
doctoral courses.

As of 31 March 2009

Researchers at Keio University in FY2008

42

3 Researchers from Outside Keio
Keio University has long emphasized the creation of an environment conducive for intellectual exchange and synergistic cooperation with researchers bothwithin and outside the institution, with the goal of sharing common or related research subject.
Not only undergraduate faculty/graduate school but also research institutes of Keio University accept researchers from other research institutions anduniversities.

Number of Researchers Accepted—Breakdown by Job Title and Status
Number of people

Number of Researchers

Job Title/Status of Researchers

Qualifications

Research Associates of Faculty of Science and Technology (Yagami)

0,032

Researchers participating in research without a contract of commissioned research.

Researchers of Keio Leading-edge Laboratory of
Science and Technology (KLL) (Yagami)

0, 67

Researchers participating in research under a commissioned research contract.

School of Medicine Researcher (Shinanomachi)

0,268

Researchers employed by research, educational, or medical institutions other than the School of Medicine of Keio
University.

Senior Visiting Researchers, Keio Research Institute at SFC(Shonan Fujisawa)

0,271

Researchers accepted by Keio Research Institute at SFC upon application from an institution not affiliated with Keio
University, or that from the applicant him/herself. Applicants must have a master’s degree or qualified as equivalent
having experience and achievements as an independent researcher.

Visiting Researchers, Keio Research Institute at SFC(Shonan Fujisawa)

0,118

Researchers accepted by Keio Research Institute at SFC upon application from an institution not affiliated with Keio
University or from the applicant him/herself. Applicants must have a bachelor’s degree or qualified as equivalent
having experience and achievements as an independent researcher.

Joint Researcher, Faculty of Pharmacy (Shiba-Kyoritsu)

0, 20

Researchers participating in research under a commissioned research contract.

Research Affiliate, Keio Advanced Research Centers (KARC) (at each campus)

116

Persons from outside Keio University pursuing internal projects for Keio Advanced Research Centers (KARC)

Visiting Professors and Researchers * (See Table A)

0,356

Others (See Table B)

1,464

Total

1,712

1

Table A: Visiting Professors and Researchers
Job Title, Status

Number of people

Mita/Hiyoshi

YagamiShinanomachi

Shonan Fujisawa

Shiba-Kyoritsu

Total

042

025

012

000

001

080

Visiting Associate Professor

016

011

012

000

000

039

Visiting Lecture

013

006

006

001

000

026

Visiting Instructor

002

002

001

000

000

005

061

047

057

002

002

169

Visiting Junior Research Fellow

018

013

002

001

003

037

Total

152

104

090

004

006

356

Visiting Professor

Visiting Research Fellow

000

00

000

Table B: Others

Number of people

Research InstituteNo. of Researchers at Keio University*2

No. of Researchers not Employed by Keio

Total

Institute of Cultural and Linguistic Studies (Mita)

027

040

0,067

Institute for Media and Communications Research (Mita)

008

034

0,042

036

042

0,078

Shido Bunko, Institute of Oriental Classics (Mita)

008

002

0,010

International Center (Mita)

063

037

0,100

Teacher Training Center (Mita) 00

044

047

0,091

Fukuzawa Memorial Center for Modern Japanese Studies (Mita)

028

039

0,067

Institute of East Asian Studies (Mita)

021

046

0,067

Center for Japanese Studies (Mita)

008

040

0,048

Research Center for the Arts and Arts Administration (Mita)

018

013

0,031

Global Security Research Institute (G-SEC) (Mita)

030

032

0,062

Research Institute for Digital Media and Content (DMC) (Mita) 0

095

020

0,115

Institute of Physical Education (Hiyoshi)

020

036

0,056

Health Center (Hiyoshi)

015

000

0,015

Keio Research Center for Foreign Language Education (Hiyoshi)

060

019

0,079

Sports Medicine Research Center (Hiyoshi)

008

011

0,019

Keio Research Center for the Liberal Arts (Hiyoshi)

215

006

0,221

Total

704

464

1,168

Keio Economic Observatory (Mita)

00000000000

Figures show the totals for FY2008
Place names in parentheses indicate location of the institution.
*1 Generic designation used for visiting professor, visiting associate professor, visiting lecture, visiting instructor, visiting research fellow and visiting junior research fellow. (Excludes researchers at
Keio listed in Table B).
*2 Researchers at Keio University: the figure indicates total number of researchers including teachers in the affiliated elementary and secondary schools of Keio, in addition to tenured and non-tenured
researchers of undergraduate faculties/graduate schools or research institutes. A researcher affiliated to more than two institutions is counted as one researcher of each.

43 Researchers at Keio University in FY2008

Intellectual Property and Technology Transfer
1 Intellectual Property
In FY2008, the IPC continued to engage in steady patent application activity with 170 domestic patent applications, 32 PCT applications, and 90 international
patent applications. The center also registered 26 domestic patents and 17 international patents.
Patent Applications
PCT

Registered Patents

International

Domestic
166

180

170

140

62

90

60

30
7 7

71

58

10 11

16

38

20

67

45

40

26

25

25

83

80

37

International

30
106

99

100

Domestic

35

146

122

120

40
20

40

170

169

157

160

37

13

17

15
11

6

5

0

13

12

10

32

7

19

17

15

1

2

2

2003

2004

0
2000

2001

2002

2003

2004

2005

2008 Domestic Patent Applications
Applications by Technology Field

2007

2006

2000

2008

2001

2002

Applications by Campus

2005

2006

2007

2008

Total Patent Applications by Inventor

Bio / Medical

34%

Yagami (Faculty of Science and Technology) Campus

98

Professors

94

Information / Communication

29%

Shinamachi (School of Medicine) Campus

34

Associate Professors

35

Control / Measurement

16%

SFC

18

Senior Assistant Professore

19

Materials / Chemicals

21%

Mita Campus

7

Assistant Professor and Research Associate

10

Hiyoshi Campus

8Students and others

11

Shiba-Kyoritsu campus

8

Employee

1

2 Technology Transfer
The IPC technology transfer officer ensures the smooth transfer of technology from university to industry. Technology transfers are conducted in the following threeforms:(I) Licensing of Keio University's intellectual property to companies(II) Start UP venture companies based on Keio University's intellectual property(III) Creation of joint research companies based on Keio University's intellectual property, and continuation of development activities in that company
In FY2008, the IPC made 29 new licensing agreements with companies. Total license income in FY2008 increased to 55.49 million yen.

Number of New Licensing Agreements

Income-Generating Licenses

70

70

60

60

63

62

50

44

40

41

50

43
37

34

44

41

40
29

26

30

57
52

30

22

20
20

20
10

10

10

0

14
8

0
2000

2001

2002

2003

2004

2005

2006

2007

Licensing Revenues

2008

Million yen

90

2000

2001

2002

2003

2004

2005

2006

2007

2008

1

1

1

2006

2007

2008

IP-Based Ventures (Start ups)
6

80
5

80
70
70

64

5

60

60

55

4

46

50

3

42

3

40
2
20

2

2

30
17

1

11

1

1

10
0

0
2000

2001

2002

2003

2004

2005

2006

2007

2008

2000

2001

2002

2003

2004

2005

The IPC collaborates with the Keio University Incubation Center to support the establishment of venture businesses. In FY2008, one company established based on
Keio IP was launched: AISSY, Inc. Thus far a total of 17 companies have been established, with Keio University holding an equity stake in 13 of them.
Intellectual Property and Technology Transfer

44

Awards for Research Activities, FY2008

Source: Keio Gijyuku Ho (Keio Biweekly Newsletter) and Keio University homepage. Entries arranged by date of award.

Date Awarded(YYYY/MM/DD)

Recipient (s)AwardReason for Award

Awarding Institution

2008/04/15

Akira Kato (Professor, Graduate School ofMedia Design) and Others

The Commendation for Science andTechnology by the Minister of
Education, Culture, Sports, Scienceand Technology

Research on TCP Communcation in Very Long-fat Pipe Environments, andas Its Result Establishment of Ten Internet2 Land Speed Records.

Minister of Education, Culture,
Sports, Science and Technology

2008/04/19

Akiko Takeda (Assistant Professor, Facultyof Science and Technology)

FUNAI Information Technology
Award for Young Researchers

For the Study: Equipment Investment Planning under Uncertainty

Funai Foundation For Information
Technology

2008/04/21

Takashi Maeno (Professor, Graduate
School of System Design andManagement)

Achievements Award from JSME
Machine Design and Tribology
Division

Due to Achievements on Actuators, Sensors and Robots

The Japan Society of MechanicalEngineers, Machine Design &Tribology Division

2008/05/08

Yuichiro Anzai (President, Professor,
Faculty of Science and Technology)

Medal with Purple Ribbon

In Recognition of Distinguished Achievement Information Science, in Particular,
Cognitive Science Related to Learning Processes Related to Thinking and
Problem Solving and in Research Related to Human-Robot Interaction

Cabinet Office, Government of Japan

2008/05/10

Masako Takahashi (Assistant Professor,
Faculy of Science and Technology)

The Prize of Business Analysis
Accosiation

The Impact of Monetary Valuation of Corporate Environmental Performance on
Economic Performance and Environmental Accounting: Applicability of LIME andJEPIX.

Business Analysis Association

2008/05/23

Yoshiyuki Matsuoka (Professor, Faculty of
Science and Technology)
Yoshiki Ujiie (Research Associate (Nontenured), Faculty of Science andTechnology) and Others

The Prize of Paper

For the Paper Entitled "Proposal of Measures of Robustness for an Objective
Characteristic with Non-normal Distribution"

Japan Society for Design Engineering

2008/05/23

Kouhei Ohnishi (Professor, Faculty of
Scinece and Technology)

IEEJ Outstanding Achievement
Award

For Pioneering Contributions to Motion Control Technology and DistinguishedServices to the IEEJThe Institute of Electrical Engineers ofJapan

2008/05/28

Hidekazu Nishimura (Professor, Graduate
School of System Design andManagement)

IBM Faculty Awards"In Recognition of Research in Model-driven Systems Development for
Collaborative and Distributed Product Engineering in the Industrial Sector"

IBM Corporation

2008/06/02

Jiro Kokuryo (Professor, Faculty of Policy
Management)

Fiscal Year 2008 MIC InfoCommunications Promotion Month
Ministerial Commendation(Individual)

In Recognition of Taking a Central Role in Deciding on Policy to Improve
Productivity based on the Utilization of Information and Communication
Technology and Contributing Greatly to the Development of Information andCommunication as a Member of the "Special Ubiquitous Zone Project"

Ministry of Internal Affairs andCommunications

2008/06/06

Takashi Maeno (Professor, Graduate
School of System Design andManagement)

Achievements Award from JSME
Robotics and Mechatronics Division

Due to Achievements on Ultrasonic Actuators and Tactile Devises

The Japan Society of MechanicalEngineers, Robotics andMechatronics Division

2008/06/14

Yoshihiro Yokoyama (Associate Professor,
Faculty of Science and Technology)

Die Preise der Japanischen
Gesellschaft für Germanistik für das
Jahr 2006 (Preiskategorie:
Wissenschaftliche Arbeiten in
Buchform in deutscher Sprache)

For Work Entitled "Lemmatisierte Konkordanz zu Wirnts von Grafenberg›Wigalois‹. Bearbeitet von Yoshihiro Yokoyama unter Mitarbeit von Ute ReckerHamm. Max Niemeyer Verlag, Tübingen 2006 (Indices zur deutschen Literatur;
Band 39) "Japan-Germany Literary Society

2008/06/26

Kouji Noguchi (Associate Professor,
Faculty of Pharmacy)

Research Incentive Award, The
Japanese Association for Molecular
Target Therapy of Cancer

In Recognition of Molecular Target Research to Develop Chemotherapy Against
Cancer-related Viruses

Japanese Association for Molecular
Target Therapy of Cancer

2008/06/29

Masafumi Hagiwara (Professor, Faculty of
Science and Technology) and Others

Good Presentation Award

According to the Presentation "Ikebana Support System Considering Sense of
Beauty"Japanese Society for the Science of
Design2008/08/12

Hitoshi Mitsuhashi (Associate Professor,
Faculty of Business and Commerce)

Distinguised Paper Award

For the Paper Entitled "Built to Last but Falling Apart: Cohesion, Friction and the
Durability of Interfirm Alliances"

Academy of Management

2008/09/02

Seiichiro Katsura (Assistant Professor,
Faculty of Science and Technology)

EPE-PEMC'08 Best Paper Award

For the Paper Entitled "Wideband Force Sensing for Haptic Energy Transmission
Utilizing FPGA".

EPE-PEMC Council

2008/09/21

Norihiko Sugimoto (Assistant Professor,
Faculty of Law)

Young Researcher Award from IEEE
Computational Intelligence Society(IEEE CIS)

For the Paper Entitled "Application of High Speed Spherial Self-organizing Map
to Climate Research"

Joint 4th International Conference on
Soft Computing Systems (SCIS) and9th International Symposium on
Adavanced Intelligent Systems (ISIS)

2008/11/01

Yoshiki Ujiie (Research Associate (Nontenured), Faculty of Science andTechnology)

Research Encouragement Award

Clarification of Macroscopic Shape Information and Its Application to Design

Japanese Society for the Science of
Design2008/11/02

Yasuaki Einaga (Associate Professor,
Faulty of Science and Technology

APA (Asian and OceanianPhotochemistry Association) Prize
for Young Scientist

Contributions to "Development of Novel Photo-functional Magnetic Materials".

The Asian and OceanianPhotochemistry Association

2008/11/11

Hitoshi Abe (Research Associate, Facultyof Science and Technology)

Best Poster Prize, International
Symposium on Surface Science andNanotechnology 5 (ISSS-5)

For the Presentation of "CO Adsorption Effects on the Magnetism and Surface
Structure of Fe/Cu (001)"

The Surface Science Society of Japan

2008/11/13

Masayuki Hashiguchi (Accosiate
Professor, Faculty of Pharmacy)

1st Research Grand Prize of Japan
Research Foundation for ClinicalPharmacology

In Recognition of the Paper Entitled "Clinical Pharmacology Research to Establish
Individualized Methotrexate-based Therapy for Rheumatoid Arthritis"

Japan Research Foundation for
Clinical Pharmacology

2008/11/14

Hideyuki Maki (Research Associate,
Faculty of Science and Technology)

The 45th Japan Electronic Material
Society Autumn Meeting Award

Bandgap Tuning of a Carbon Nanotube with an Uniaxial Strain, and Application
to Optoelectronic Devices

Japan Electronic Material Society

2008/11/21

Yasuhiro Kakinuma (Assistant Professor,
Faculty of Science and Technology)

Manufacturing and Machine Tool
Award for Academic Achievement

For the Paper Entitled "Application of Electro-rheological Gel to Fixture Devices
for Micro Milling Processes"

The Japan Society of MechanicalEngineers Manufacuturing andMachine Tool Division

45 Awards for Research Activities, FY2008

Date Awarded(YYYY/MM/DD)

Recipient (s)AwardReason for Award

Awarding Institution

2008/12/01

Hideko Kanazawa (Professor, Faculty of
Pharmacy)Award of the Society for
Chromatographic Sciences, Japan(2008)Development of Novel Thermally-Responsible Sapatarion Systems Using
Functional Polymers

The Society of Chromatographic
Sciences

2008/12/22

Atsuhiro Yamada (Associate Professor,
Faculty of Economics) and Others

4th Outstanding Performance Award
of Institute for Health Economics
and Policy

In Recognition of the Paper Entitled "Utilization Experiment on Nursing-careInsurance and the Fairness of Nursing-care Service"

Institute for Health Economics andPolicy2009/03/09

Kohei Itoh (Professor, Faculty of Scienceand Technology)

JSPS Prize

Establishment of Semiconductor Isotope Engineering: Prof. Itoh has Proposed theImportance of Isotopic Control of Semiconductor Elements and Demonstrated Its
Application to State-of-the-art LSI Technologies and Quantum Computer
Development.

Japan Society for the Promotion of
Science (JSPS)

2009/03/12

Seiichiro Katsura (Assistant Professor,
Faculty of Science and Technology)

Yazaki Academic Award

Research Development of Multilateral Haptic Transmission Technology for
Haptic Broadcasting

Yazaki Memorial Foundation for
Science and Technology

2009/03/17

Daisuke Uemura (Professor, Faculty of
Science and Technology)

The Naito Foundation Resaearch
Prize

Exploratory Research on Bioactive Natural Products with Focus on Biological
Phenomenon

The Naito Foundation

2009/03/18

Seiichiro Katsura (Assistant Professor,
Faculty of Science and Technology)

2008 IEEE Excellent Presentaion
Award

For the Paper Entitled "Extraction and Visualization of Writing Pressure by Haptic
Pen"

The Institute of Electrical Engineersof Japan

2009/03/28

Masahide Takanashi (Co-ed Elementary
School (Keio Yochisya), Teacher

The Chemical Society of Japan
Award for Merits for Chemical
Education for 2008

Practice and Dessemination of Science Education Developing Curiosity

The Chemical Society of Japan

2009/03/28

Atsushi Nakajima (Professor, Faculty of
Science and Technology)

The Chemical Society of Japan
Award for Creative Work for 2008

Study on Creation of Nano-scale Materials Based on Composite Clusters andTheir Electronic Properties

The Chemical Society of Japan

2009/03/28

Teruhiko Matsubara (Assistant Professor,
Faculty of Science and Technology)

Young Scholar Lecture Series of The
Chemical Society of Japan for 2009

Special Lecture "Control of Cell Surface Glycoconjugate Functions by Peptides
which are Selected from Random Library"

The Chemical Society of Japan

2009/03/29

Kazuhiro Sakai (Research Associate (Nontenured), Faculty of Economics

Young Scientist Award of the
Physical Society of JapanFor Work Entitled "Verification of AdS/CFT Correspondence Based on
Integrability"

The Physical Society of Japan

Introduction to the Keio University research databases
K-RIS（Keio Research Information System）

Keio Leading-Edge Laboratory of Scienceand Technology (KLL) Yellow Pages

Keio Research Institute at SFC Yellow Pages

K-RIS provides information on all researchers at Keio
University. The database can be searched in various ways,
including by keyword, researcher affiliation, or publishedpaper.

Introduction to the current research projects at the Yagami
Campus, Science and Technology Department.

Introduction to the current research projects at the ShonanFujisawa Campus Research Institutehttp://www.kll.keio.ac.jp/db/index.html

http://www.kri.sfc.keio.ac.jp/kris-yp/

http://www.k-ris.keio.ac.jp/index_en.html

Awards for Research Activities, FY2008 / Introduction to the Keio University research databases

46

Research-related Facilities and Libraries
Research Space for Rent
Keio University provides research space and incubation facilities for rent as indicated below. Policies and availability differ by campus, so please inquire in advance for vacancies, rental
qualifications, application procedures, application deadlines, etc.
As of June 2009

Facility

Outline•For Inquiries

Kyoseikan Collaboration Space(See pages 15-16)

Total of 5 rooms in Kyoseikan Building on Hiyoshi Campus
Size: each room: 20.82m2; Total floor area: 104.10m2•Kyousei-Kan Operations Center•Tel. +81-45-564-2500•http://campus.hc.keio.ac.jp/kyoseikan/•E-mail: hc-kyoseikan@adst.keio.ac.jp

Research Space at the KLL(See pages 17-18)

Total of 31 rooms in Sousoukan Building on Yagami Campus
Size: 66.12m2 - 102.49m2 ; Total floor area: 2,245m2
Type A (for chemistry and biology experiments)
Type B (for applied physics experiments)
Type C (for experiments for heavy materials)
Type D (for experiments for light-weight equipments)
Type E (for various types of experiments)•Secretariat of the KLL•(c/o Office of Research Administration, Yagami Campus)•Tel. +81-45-566-1794•http://www.kll.keio.ac.jp/•E-mail:staff@kll.keio.ac.jp•KLL Liaison Office•http://www.kll.keio.ac.jp/liaison/

Shinanomachi Research Park
(See pages 19-20)

56 units in the Institute of Integrated Medical Research Building
Steel frame with a reinforced concrete structure; 2 under ground floors,
9 above ground floors, and one penthouse floor
Total floor area: 24,400m2•Shinanomachi Office of Research Administration•Tel. +81-3-5363-3879•http://www.med.keio.ac.jp/research/•E-mail: ras-shinanomachi@adst.keio.ac.jp•Center for Integrated Medical Research•http://www.cimr.med.keio.ac.jp/

Keio Fujisawa Innovation Village(SFC-IV)(See page 22)

Steel frame structure, 2 floors
Site area: 1,825.3m2
Total floor area: 1,470.0m2
Rental space: 906.4m2
offices: 18; small offices: 3; shared offices: 8
R&D fabrication rooms: 3; office/R&D fabrication rooms: 2
server room: 1•Keio Fujisawa Innovation IM Room
•Tel. +81-466-49-3910•http://www.sfc-iv.jp/index.html•E-mail: incubation@sfc-iv.jp

Shin-Kawasaki Town Campus(See page 25-26)

Four research buildings
Steel-frame structure, 2 floors
Total floor area: 5,336.11 m2•Shin-Kawasaki Town Campus•Shin-Kawasaki Frontier Research and Education Collaborative Square•Tel. +81-44-580-1580•http://www.k2.keio.ac.jp•E-mail: k2-tc@adst.keio.ac.jp

Tsuruoka Metabolome Campus(Tsuruoka Leading-Edge Research
Industrial Support Center - not a Keio
facility.)(See page 28)29 units, Size: 7m x 10m x 2.8m
Steel frame structure, 2 floors
Total floor area: approximately 3,700m2•Planning and Coordinating Division, Department of General Affairs,•Tsuruoka City
•Tel. +81-235-25-2111(ext. 321)•http://www.city.tsuruoka.lg.jp/•E-mail:kikaku@city.tsuruoka.yamagata.jp

Sousoukan Building on Yagami Campus

Keio Fujisawa Innovation Village

Library Collections
Keio University has six campuses: Mita, Hiyoshi, Shinanomachi, Yagami, Shonan Fujisawa, and Shiba-Kyoritsu, each one of them developing leading-edge research and education in various
disciplines, and also high-level medical practice. The Media Centers, centering the library service, branch on each campus to provide intensive support for all these specific activities.
As of March 31, 2009
Book Stocks
Total

Collections by Material Type
Domestic Books

Number of
Seats

Foreign Books

Domestic Journals

Foreign Journals

Non-book Materials(items),Mita Media Center

2,663,320

955,556

1,036,894

246,773

291,222

132,875

1,324

Hiyoshi Media Center

873,569

470,490,224,990

68,71772,802

36,570

1,433

Shinanomachi Media Centerr

403,843

70,23250,80990,277

185,980

6,545

226

Information and Media Center for Science and Technology

364,704

94,36344,61456,466

165,280

3,981

475

Shonan Fujisawa Media Center

407,643

222,570

86,29846,66825,78626,321

1,080

Information and Media Center for Pharmaceutical Sciences

70,66139,061

5,132

7,395

17,592

1,481

141

4,783,740

1,852,272

1,448,737

516,296758,662

207,773

4,679

Total

There are also electronic media resources (348 databases, 42,369 electronic journals, and 11,784 electronic books).
In the Hiyoshi Media Center, the collections of the Kyousei-Kan library (Business Management graduate courses, Systems, Management graduate courses, and Media Design graduate courses) were included from FY2008.

New University Library at Mita Media Center

47 Research-related Facilities and Libraries

Hiyoshi Media Center

Shinanomachi Media Center

FY2008 Financial Position
Ended on March 31, 2009

1 Balance Sheet
Million yen

AssetsLiabilities

Fixed assets

323,271

Tangible fixed assets

207,149

Long-term borrowings

0014,689

Land

033,956

School bonds

003,558

Buildings

0103,923

Retirement allowance reserve

028,530

Structures

004,988

Pension reserve

018,941

Equipment and supplies for023,693

Fixed liabilities

065,718

education and research
Current liabilities

037,247

Other equipment and supplies

000,566

Books

039,525

Short-term borrowings *2002,979

Vehicles

000,022

School bonds *2

001,439

Construction in progress

0011475

Accounts payable

017,340

116,122

Advances received

013,312Land lease rights

000,000

Deposits

002,086

Telephone subscription rights

000,072

School trip deposits

000,92

Facility use rights

000,187

Other fixed assets

Deposits

000,005.22

Profit-making business capital

005,692

Long-term loans

Liabilities total

0102,965

Funds

Specified assets *062,920

Funds

School bond assets producing interest

004,997

First fund *3

305,561

Reserve assets for the third fund040,399

Second fund *40015,450

Third fund *5

040,399

Current assets

045,953

Fourth fund *6009,076

Cash deposits

025,385

Accounts receivable

013,792

Inventories

000,523

Balance of income and expenditure

Negotiable securities

05,152Carried forward to next year

Funds total

370,485

104,226000,92Others000,1,008

Assets total

369,224*1 Specified assets
Assets reserved for specific purposes such as the "retirement allowance
reserve," the "pension reserve," and the "Second Fund."*2 Short-term borrowings and school bonds
Current portion of "long-term borrowings" and "school bonds (Jukusai)"
expected to be repaired in FY2009.

001,832
1

Assets for school trip deposits

Keio Corporate Administration “Jukukan-kyoku” at Mita Campus*3 First Fund
Funds related to the acquisition and maintenance of fixed assets(acquisition cost of fixed assets such school land, school buildings,
equipment and supplies, books, etc. acquired by self-financing).
*4 Second Fund
Fund related to future acquisition of fixed assets.
*5 Third Fund
Amount of assets related to scholarships and research funds.
*6 Fourth fundRequired working capital.

Total of liabilities, funds, and balance ofincome and expenditure369,224

Source: Activities and Financial Position of Keio Gijuku: FY2008 Business
Report2 Income and Expenditure Statement
Million yen

IncomeAll of Keio
(Keio Gijuku)

University
only

Imputed income

Expenditure

All of Keio
(Keio Gijuku)

University
only

Personnel

65,057

34,96859,96832,918
1,705

Tuition and other student fees

47,03139,395

Expenses for education andOther fees

2,468

2,169

research*3

Donations*1

22,6483,275

Expenses for general administration

5,414

Subsidies*2

14,422

12,275Interest on borrowings

391

151

Income from asset management

3,109

332

Loss on disposition*4

17,232258

920Discretionary reserve--

Total expenditure

148,155

70,000Asset sales differential

440Income from business

9,061

8,703

Income from medical services

44,0460

Miscellaneous income

3,739

3,004

Imputed income total

146,566

69,154

Transfer to capital fund

△ 25,319△ 6,715

Provision for allowance for
doubtful accounts

Current excess over expenditure

26,908-

Brought forward from last year

77,318-Carried forward to next year

104,226-△ 1,589△ 846*1 Donations
Due to consolidation, this includes approximately 4.3 billon yen in general
donations and approximately 8.3 billion yen contributions in goods.
*2 Subsidies
In FY2008, subsidies from the Promotion and Mutual Aid Corporation forPrivate Schools in Japan (PMAC) totaled ¥8,863,615,000. General subsidies
account for ¥6,170,065,000 of this amount and special subsidies account for¥2,693,550,000. Since subsidies for Grants-in-Aid for Scientific Research
are allocated to individual researchers, they are processed as deposits ofthe school juridical organization and thus are not reported in the subsidy
revenue, which is considered to be imputed income in the financial
statement. Accordingly, expenditures corresponding to these subsidies are also
excluded from expenditures for education and research.
*3 Expenses for education and research
Research activities funded by subsidies such as Grants-in-Aid for Scientific
Research (Kakenhi) are not included (please see *2 above)*4 Loss on disposition
Approximately 17 billion yen is based on the valuation of financial assets.
Source: Activities and Financial Position of Keio Gijuku: FY2008 Business
Report

Imputed income total Income total

121,246

62,439Total expenditure

FY2008 Financial Position48

Access Information

Mita Campus

Shinanomachi Campus

2-15-45 Mita, Minato-ku, Tokyo 108-8345
Tel +81-3-5427-1517

35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582
Tel +81-3-3353-1211

8-minute walk from Tamachi St. (JR Yamanote Line or JR Keihin
Tohoku Line);
Approximately 10 minutes by train from Tokyo to Tamachi.
Approximately 20 minutes by train from Ueno to Tamachi.
Approximately 15 minutes by train from Shibuya to Tamachi.
7-minute walk from Mita St. (Asakusa or Mita Line);
Approximately 15 minutes by train from Suidobashi to Mita.
8-minute walk from Akabanebashi St. (Oedo Line)

Hiyoshi Campus

Shonan Fujisawa Campus

4-1-1 Hiyoshi, Kohoku-ku, Yokohama-shi,
Kanagawa 223-8521
Tel +81-45-566-1000

5322 Endo, Fujisawa-shi, Kanagawa 252-8520
Tel +81-466-47-5111

1-minute walk from Hiyoshi St. (Tokyu Toyoko Line or Yokohama
Subway Line, Green Line);
Approximately 25 minutes by train from Shibuya to Hiyoshi(20 minutes by express).
Approximately 20 minutes by train from Yokohama to Hiyoshi(15 minutes by express).
Approximately 20 minutes by train from Shin-Yokohama to Hiyoshi
via Kikuna.

Approximately 15 minutes by bus from Shonandai St.
(Odakyu Enoshima Line, Sagami Tetsudo Izumino Line, or Yokohama
Subway Line);
Approximately 30 minutes by train from Yokohama to Shonandai.
Approximately 25 minutes by bus from Tsujido St. (JR Tokaido Line);
Approximately 30 minutes by train from Yokohama to Tsujido.

Yagami Campus

Shiba-Kyoritsu Campus

3-14-1 Hiyoshi, Kohoku-ku, Yokohama-shi,
Kanagawa 223-8522
Tel +81-45-566-1454

1-5-30 ShibaKoen, Minato-ku, Tokyo 105-8512
Tel +81-3-3434-6241

15-minute walk from Hiyoshi St. (Tokyu Toyoko Line or Yokohama
Subway Line, Green Line);
Approximately 25 minutes by train from Shibuya to Hiyoshi(20 minutes by express).
Approximately 20 minuets by train from Yokohama to Hiyoshi(15 minutes by express).
Approximately 20 minutes by train from Shin-Yokohama to
Hiyoshi via Kikuna.
Approximately 10 minutes by car from Shin-Kawasaki St.
(JR Yokosuka Line);
Approximately 20 minutes by train from Tokyo to Shin-Kawasaki
Approximately 12 minutes by train from Shinagawa to Shin-Kawasaki.
Approximately 9 minutes by train from Yokohama to Shin-Kawasaki.

49 Access Information

1-minute walk from Shinanomachi St. (JR Sobu Line);
Approximately 6 minutes by train from Shinjuku to Shinanomachi.
Approximately 15 minutes by train from Tokyo to Shinanomachi.
5-minute walk from Kokuritsu-kyogijo St. (Oedo Line)

10-minute walk from Hamamatsu-cho St.
(JR Yamanote Line or Keihin-Tohoku Line)
Approximately 6 minutes by train Tokyo to Hamamatsu-cho
Approximately 13 minutes by train from Ueno to Hamamatsu-cho
Approximately 16 minutes by train from Shibuya to Hamamatsu-cho
2-minute walk from Onarimon St. (Mita Line)
Approximately 5 minutes from Ote-machi to Onarimon
Approximately 35 minutes from Hiyoshi to Onarimon
6-minute walk from Daimon St. (Asakusa Line or Oedo Line)
Approximately 16 minutes from Shinjuku to Daimon
Approximately 7 minutes from Nihonbashi to Daimon

Contact Information
Shin-Kawasaki Town Campus

Shonai Airport

7-1 Shin-Kawasaki, Saiwai-ku, Kawasaki-shi, Kanagawa
212-0032
TEL+81-44-580-1580

Bio-Lab, Institute forAdvanced Biosciences (IAB),
Keio University

ata
Sak

Mita Campus• ORAA: Organization for Research Advancement andAdministrationoraa-jimukyoku@adst.keio.ac.jp
CRP: Center for Research Promotion
crp@info.keio.ac.jp
IPC: Intellectual Property Center
toiawasesaki-ipc@adst.keio.ac.jp
Head Office of Research Administration
ora-honbu@adst.keio.ac.jp
Office of Research Administration, Mita Campus
mshien-ft@adst.keio.ac.jp
KIC: Keio Incubation Center
incu-jimu@adst.keio.ac.jp
KARC: Keio Advanced Research Centerskarc-jimu@adst.keio.ac.jp

N

R7

a
gat
Nii

10-minute walk from Shin-Kawasaki St. (JR Yokosuka Line);
Approximately 20 minutes by train from Tokyo to Shin-Kawasaki.
Approximately 12 minutes by train from Shinagawa to ShinKawasaki.
Approximately 9 minutes by train from Yokohama to Shin-Kawasaki.
15-minute walk from Kashimada St. (JR Nambu Line);
Approximately 7 minutes by train from Kawasaki to Kashimada.

Tsuruoka
ChuoHigh School

JR Tsuruoka St.
Tsuruoka Metabolome Campus

Yamagata University Faculty of Agriculture
Tsuruoka Minami Tsuruoka Kita
High School
High School
Tsuruoka TechnicalHigh School
Chido
MuseumOhyamaCity Library
Police Box

Hie
ShrineTsuruoka Park

Daitokuji
TempleTsuruoka
City Hall
Chidokan
Cultural
Hall
a/A
kita

Hiyoshi Campus• Office of Research Administration, Hiyoshi Campus
ras-hiyoshi@adst.keio.ac.jp

Sa

kat

Tsuruoka Town Campus
Campus Center, Institute forAdvanced Biosciences (IAB),
Keio University

HaguroR112

Chido Library
Graduate School, Tohoku University of Community
Service and Science
Tsuruoka Park Rest House
Training Building

Yagami Campus• Office of Research Administration, Yagami Campus
yg-shien@adst.keio.ac.jp• Secretariat of Keio Leading-edge Laboratory of
Science and Technology (KLL)
staff@kll.keio.ac.jp

Yamagata

Tsuruoka Town Campus
Center Building
14-1 Baba-cho, Tsuruoka-shi, Yamagata 997-0035
TEL +81-235-29-0800

Shinanomachi Campus• Office of Research Administration,
Shinanomachi Campus
ras-shinanomachi@adst.keio.ac.jp

Air
Train

Tsuruoka
Shonai Airport
Sendai

Niigata
Bio-lab403-1 Nipponkoku, Daihouji, Tsuruoka-shi,
Yamagata 997-0017
TEL +81-235-29-0534

Shonan Fujisawa Campus• Office of Research Administration,
Shonan Fujisawa Campus
info-kri@sfc.keio.ac.jp
Shiba-Kyoritsu Campus
skc-shien@info.keio.ac.jp

Tokyo
Haneda Airport

Osaka• Shin-Kawasaki Town Campus
k2-tc@adst.keio.ac.jp

Keio University
Shonan Fujisawa Campus• Tsuruoka Town Campus
office@ttck.keio.ac.jp

By air: approximately 50 minutes from Tokyo Haneda Airport
to Shonai Airport, approximately 25 and 18 minutes by carfrom Shonai Airport to Center Building and Bio-lab,respectively.
By train: approximately 120 minutes by Joetsu Shinkansen(bullet train) from Tokyo St. to Niigata St., then approximately
120 minutes by Uetsu Honsen (main line) from Niigata St. to
Tsuruoka St., then 5 minutes by car

JR local lines
JR Yamanote Line

JR Shinkansen
Private railways

JR KeihinTohoku Line

SubwayBus
Oedo Line
Namboku Line
Shinjuku

Nagatsuta

Sagamiono

JR Nambu Line

HiyoshiCampus

MachidaAzaminoChuo-Rinkan
JR Yokohama Line

Shin-Yokohama

Shinanomachi

Odakyu Line

Yokohama
SubwayBlue Line

Futamatagawa

Shonan Fujisawa
Campus

Sotetsu
IzuminoLine

Shonandai

Akihabara

Namboku Line

Shibuya

HiyoshiDen-en-chofu
Musashi-Kosugi

Tokyu
Toyoko Line

Mita LineJiyu-gaoka

Ebisu

Tokyu Meguro Line

JR Yokosuka Line

Shin-Kawasaki

Tokyo

HibiyaNakameguro
Azabu-Juban

JR Tokaido Shinkansen

Kikuna Shin-Kawasaki

Ochanomizu

Suidobashi

Yokohama Subway
Green Line

Town Campus

JR Tokaido Shinkansen

JR Sobu Line
Iidabashi

Kokuritsukyogijyo

Futakotamagawa

YamatoOdakyu Enoshima Line

Yotsuya

YoyogiTokyu
Denentoshi Line

Nakayama

Sotetsu Line

Shinanomachi
Campus

JR Chuo Line

YagamiCampusAsakusa Line

Mita
CampusMeguroGotandaHibiya Line

Shiba-Kyoritsu Campus

OnarimonAkabanebashi

Daimon

Shimbashi

Mita

Oedo Line

Kashimada
Hamamatsucho
Yokohama

Kawasaki

JR Tokaido Line

Oimachi

ShinagawaTamachiKeikyu-Kamata
Totsuka
TsujidoKeihinkyuko LineFujisawa
Haneda Airport

Tokyo Monorail

Access Information50

150th Anniversary in 2008

Keio University
Annual Report on Research Activities
2008–200916 November 2009
Published by the Organization for Research
Advancement and Administration
2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan
TEL: +81-3-5427-1517
http://www.keio.ac.jp/index-en.html©Keio University 2009200911.5000.B