Mission Statement
The tropics, the most ecologically diverse region on the Earth, presents an ongoing complexityof tropical diseases and other health problems. In view of the remarkable advances made in the field ofinternational exchange in recent years, it is imperative that these problems be addressed from a global
perspective.
Based on this understanding, the Institute of Tropical Medicine, Nagasaki University, aims to
overcome tropical diseases, particularly infectious diseases, and the various health problems associatedwith them. In cooperation with related institutions, we strive for excellence in the following areas:
1. Spear-head research in tropical medicine and international health
2. Global contributions through disease control and health promotionin the tropics by applying the fruits of our research
3. Cultivation of researchers and specialists in the above fields

Organizational Chart

Microbiology and Parasitology
Department of Virology

Department of Emerging Infectious Diseases

Department of Bacteriology（Professor selection in progress)

Department of Protozoology

Department of Parasitology

Department of Molecular Epidemiology(Overseas Visiting Professor)

Nagasaki University
Hospital
Steering
Cmte ITM

Dean

Department of
Pathology

Steering Cmte
RCTD

Department of Clinical Medicine

Public and Environmental Health
Department of
Eco-epidemiology

Department of Global Health
Development Policy Sciences

Department ofInternational Health andMedical Anthropology

Department of Vector
Ecology and Environment

Department of Pediatric Infectious Diseases

Department of Clinical Product Development

Faculty
Meeting

Management
Meeting

Associated Facilities
Center for Infectious Disease Research in Asia and Africa

Department of
Host-Defense Biochemistry

Department of Preventive
Medicine and AIDS Research

Department of
Infections Diseases

Clinical Medicine and Research

Host and Vector Biology
Department of
lmmunogenetics

Internal
Medicine

Kenya Research Station

Vietnam Research Station

Tropical Medicine Museum
Tropical Medicine Research
Department Division

Central Research LaboratoryOﬃce for Training and Education
NEKKEN BioResource Center

NEKKENNTD Innovation CenterOﬃce of Coordination for Humanitarian Aﬀairs

Shionogi Global Infectious Diseases Division
Department of Cellular
Architecture Studies

Department of Molecular
Infection Dynamics

Department of
Immune Regulation

Department of Exploratory
Research for Drug Discovery

Steering Committee for the Institute of Tropical Medicine (Committee Member outside the university)
Hiroyoshi Endo（St.Luke's International University），Norio Ohmagari（National Center for Global Health and Medicine），
Hitoshi Oshitani（Tohoku University)，Shigeyuki Kano（National Center for Global Health and Medicine），
Gakunan Gen（Obihiro University of Agriculture and Veterinary Medicine），Yasuhiko Suzuki (Hokkaido University )，Takaji Wakita（National Institute of Infectious Diseases），Tiho Watanabe（National Institute for Environmental Studies）

01

Towards Eradication of
Tropical Infectious Diseases
Institute of Tropical Medicine (NEKKEN), Nagasaki University is a unique governmental
institution for research on tropical medicine. The Ministry of Education, Culture, Sports,

H istory
1942.3on Tropical Disease” in 2009. This recognition underlines the importance of NEKKEN as anopen institute whose resources are freely available to the whole research community inJapan. Since 1993, the World Health Organization has designated NEKKEN as a WHO
Collaborating Centre for Reference and Research on Tropical Viral Diseases. The current
organization of the institute involves five major research fields ( 21 departments ), twofacilities, and one clinical unit at University hospital.
Many developing countries are located in the tropics, and are affected by a diverse
group of tropical diseases, and emerging infectious diseases. As a consequence theremarkable advances made in the field of international transportation and communicationin recent years, the industrialized countries of the temperate zones are also threatened by

1946.4
1949.5

Based on this paradigm, NEKKEN aims to overcome tropical and emerging infectious
institutions, and to strive for excellence in the following areas:

1967.6
1967.6

Institute of Tropical Medicine, N.U.
Added the Ward Tropical Internal

1978.4

Diploma course, Kensyu-katei

1983.4

JICA Researcher Group-Course

1989.5

Certified as Joint Usage ResearchCenter1993.11

WHO Collaboration Center

1995.4

Certified as Center of Excellence, COE

1997.4Tropical Infection Research Center

2. International contribution through disease control and health promotion in the tropics

COE program 21st Century Global
Strategy against Tropical & Emerging

3. Cultivation of researchers and specialists in the above fields

Infection

This pamphlet offers a brief, but hopefully intelligible explanation of our organizationand its activities. As you will see, our research activities address major tropical diseases
such as malaria, schistosomiasis, dengue fever, and yellow fever, and emerging and2006.4Tropical Medicine Masterʼs Course

2008.4

Museum and Asia / Africa Facilities

2008.6re-emerging infections such as HIV/AIDS, SARS, ebola and tuberculosis. We conduct basic
also investigate entomology, ecology and social sciences. NEKKEN is also contributing to theeducation of students in PhD, and Masters as part of the Graduate School of Biomedical
Sciences and the Graduate School of Tropical Medicine and Global Health of Nagasaki
University. In addition, NEKKEN provides a three-month training course on tropical medicine.
You will also find information about our research facilities in Kenya and Vietnam.
Hopefully you will be able to understand the intention of our research and education andKouichi, Morita
Dean and Professor
NEKKEN
May, 2019

COE

programComprehensive

Global Strategy against Tropical &medical sciences, epidemiology and clinical research for disease prevention and control. We

will support us in the future.

Institute of Endemics, Nagasaki

Medicine, to University Hospital

2003.4

1. Spear-head research in tropical medicine and global healthInstitute of Endemics, N.M.C
University, under postwar scheme

the same pathogens and it is imperative that they are addressed from a global perspective.
diseases, and the various related health problems in the tropics, in cooperation with related

East Asia Institute of Endemics as
Nagasaki Medical College affiliate

Science and Technology (MEXT) designated NEKKEN as a “Joint Usage / Research Center

Emerging Infection
2009.6

Certified as Tropical-medicine Joint
Usage / Research Center2011.42012.4

Two clinical-field departments
Global Leader Course for Tropical& Emerging Infection Intervention

2017.112019.475th anniversary ceremony
Shionogi Global Infectious Diseases
Division

02

Joint Usage / Research Center on Tropical Disease
Our institute is the one and only public sector institutesupported by MEXT (Ministry of Education, Culture,

carries out joint research rooted in the local places where
the infectious diseases are prevalent.

Sports, Science and Technology, Japan) that aims to
conduct research on tropical diseases, and is identified as
the Joint Usage / Research Center on Tropical Disease.

2. Outline of the Centerʼs Activities

The Joint Usage / Research Center on Tropical

Medicine supports collaborative research, which is either
1. The Goal of the Center

basic

Infectious diseases are caused by the collapse of

epidemiological, clinical or public health framework. It

symbiosis with other creatures, which cannot be avoided if

also supports research meetings, which promote andorappliedresearch

based

upon

an

we, human beings, live in nature. Although the ultimate aim

facilitate research into infectious diseases throughof this center is to eradicate infectious diseases, it isexchanging information or technology where necessary.

needed rather to establish reciprocal relationships with

The Center serves as a bio-resource center to deliver

other creatures than to eliminate them. Such establishment

such things as infectious agents, information. collectedof reciprocal relationships requires collective knowledge,

and stored here.

which can be achieved only by combining a broad aspectof disciplines.
Tropical infectious diseases have been spreading in
tropical areas, which is a reflection of the environment and3. Operational Organization of the Center

As for administration of this research center, the deanof the Institute of Tropical Medicine established thesocio-economic situation existing there. It is considered toSteering Committee for the Center, which is composed of

be a big challenge related to health. Emerging and re-emerging

11 members, out of whom more than half should be from

infectious diseases have been spreading globally withoutside the university concerned. The Steering Committee

tropical areas at the epicenter. Tropical areas are not onlyis responsible for the adoption of the applications, andthe battle field where we, human beings, fight against

monitoring and evaluation of the activities.

them, but also the experimental ground where we newly

In order to support the above mentioned activities acreate and develop our knowledge and technology in orderspecific administrative office supporting the Center is

to control infectious diseases.

allocated in the institute and a professor is designated toAgainst the backdrop of past international activities

be a section chief.

and research facilities for infectious diseases in Asia andAfrica, the Joint Usage / Research Center on Tropical
Disease, together with researchers from diverse fields,

The Institute ofTropical Medicine
Dean
Advice / Report

Steering Committee for the Joint Usage /Research Center on Tropical Disease

Researchers Communities

Discuss important matters on its
management

a member of the committee

Expert advisors

Discuss enquiries on specialized matters

The Joint Usage / Research Center on
Tropical Disease Oﬃce
Support for its management and follow
the intention of the committee

Send a delegate/delegates as
to address opinions from
communities

Research Grants
A collaborative Research Topic
A collaborative Research Topic
A collaborative Research Topic

Steering Committee for the Joint Usage / Research Center on Tropical Disease（Committee Member outside the university）
Manabu Ato（National Institute of Infectious Diseases），
Shinichiro Kawazu（Obihiro University of Agriculture and Veterinary Medicine），Satoshi Sasaki（The University of Tokyo），
Kyoko Sawabe(National Institute of Infectious Diseases)，Akira Nishizono（Oita University），
Sohkichi Matsumoto（Niigata University），Takayuki Miyazawa（Kyoto University）

03

Accounting (FY2018)
owmentEndowment
ernal Fund）（External
90
95,790Grant-in-Aid for
Scientiﬁc Research Others
5,860
134,341d Project
Commissionedd）（External Fund）
15,631

Grant-in-Aid forEndowment
Scientiﬁc Research（External Fund） 115,670
Others
22,5675,860

AdAdministrativecocost subsidy
645,349
645,349

Commissioned
ssioned Projectal Fund）（External
12,871

AdminisAdministrative
cost subsubsidy645,349

Revenue

Expenditure（thousand JPY）
Total
2,241,121ssioned ResearrchCommissioned
Research
al Fund）（External
1,065,534（thousand JPY）
Total
1,836,988

Non-sue
Non-subsidy income
at Nagaty
Nagasaki University
140,822

Commissione
Commissioneded
Researchd）（External Fund）
843,799

Joint Research（External Fund）
137,795

Joint Research（External Fund）
53,550※Including carry-overNon-subsid income
Non-subsidy
at Nagasak
Nagasaki University
137,322

External Fund (FY2018)
Amount（in thousands of yen）
800,000

Numberof grants

790,099

700,000

608,756

600,000

100

82

80

500,000

60

400,000
300,000

30

200,000

116,921 17

100,000
043,16240

28

15,631

5,630

5

2

Joint Research with Commissioned Commissioned Endowments
Private Sectors
Research
Project

Facilities & Administrative
costs included

20

Others0

Total

Number of Staf f （as of May 1 ,2019）
Professor

Associate
Professor

Senior AssistantProfessor

Assistant
Professor

Sub total

Others

Total

15

8

1

30

54

89

143

Grants-in-aid for Scientiﬁc Research （KAKENHI）（MEXT）（FY2018）

Amount（in thousands of yen）
100,000

98,32532

75,000030
25

17,42050,00025,000

Numberof Grants
35

19,50014,8202
ScientiﬁcResearch(A)(General)

5

14,5609
3

ScientiﬁcScientiﬁcResearch(B) Research(B)(Overseas(General)AcademicResearch)

20

14,430
5,200
2

3,120
1

3,120
2

15

5,720

435
1

4

2

0

10
5

1

Research
Young
Joint
Scientiﬁc Challenging Challenging Challenging Young
Research(C) Exploratory Exploratory Research Scientists Scientists International Activity
Start-up(A)(B)
Research(General)ResearchResearch (Exploratory）
Promotion

Total

0

04

This Department has been conducting basic

Research on the pathogenicity of arboviruses

and applied research on arthropod-borne viruses

and evaluation of therapeutic compounds using

Microbiology
and Parasitology(arboviruses) such as Japanese encephalitis virus

animal model.

Department of
Virology(JEV), dengue virus (DENV), Zika virus, Chikungunya

We elucidate the mechanism of pathogenicity

virus (CHIKV) and severe fever with thrombocytopenia

and infectivity of arboviruses, such as DENV andsyndrome virus (SFTSV).

SFTSV by using a mouse model.
Development of rapid diagnostic assay for

Molecular epidemiology of arboviruses
We isolate DENV, JEV and CHIKV in Asia
and African regions and conduct molecular

Various rapid diagnostics are being developed

epidemiological analysis to determine international

for arboviruses using PCR, LAMP, LC/MS andand inter-continental movement of these viruses.

Immuno-chromatographic technologies for the

We also analyze unique genome sequences that

detection of viral genome, protein and specificare relevant to pathogenicity.

antibodies.

Researchonvaccinedevelopmentusingreverse genetics
We have developed DENV infectious clones

Professor

Kouichi Morita
Associate Professor

Moi Meng Ling
Associate Professor

Shingo Inoue

Tropical Viral Diseases since 1993 and currently ourdepartment has been re-designated as a center for

developing genetically engineered viruses as

Tropical and Emerging Virus Diseases. The centercandidates for live attenuated DENV vaccines by

has been collaborating with WHO in training WHO

financial support of GHIT.

fellows from many developing countries and has
deployed experts as WHO short-term consultants.
1. Ngwe Tun et al. $P-7URS0HG+\J 2018;98:868-871.
2. Ly et al. %0&,QIHFW'LV 2018;18:31.
3. Bui et al. -*HQ9LURO 2018;99:1044-1057.
4. Raekiansyah et al. $UFK9LURO 2018;163:1649-1655.
5. Moi et al. /DQFHW,QIHFW'LV 2017;17:805-806.

Assistant Professor

Mya Myat Ngwe Tun

Malaria is responsible
for a huge burden●新興感染症学分野では、
分子〜細胞〜動物個体

the parasiteʼslife cycle, such as ・themolecular●新興・再興感染症の病原体を迅速簡便かつ高感of death and disease in large areas of the〜生態系レベルでウイルス研究を進めることによinteractions and signaling mechanisms behind
度に検出できる新規検査法を開発している。

tropical and sub-tropical world. Unfortunately,

り、ウイルス感染症の制圧を目指している。

those countries hardest hit by the disease areoften amongst the poorest. Despite continuing

We utilize a variety of malaria parasites including

イルスなどの出血熱ウイルスやインフルエンザウイ
against the disease. In order to design andて、
ランバレネ医療研究センターとの国際共同研究
rodentmalaria parasite 3ODVPRGLXP\RHOLL, andstrategies, we believe that one of the key
細胞内でどのようなメカニズムで増殖しているのか

human malaria. To expand a platform for basic
イルス感染症の診断法の導入を行っている。

priorities
in malaria
research should be theを解析している。
特に、ウイルス性因子と宿主因子

and clinical malaria research, we are investigating

human-infecting 3ODVPRGLXP IDOFLSDUXP, theとして現地のウイルス感染症の実態調査とそれらウ
3ODVPRGLXPNQRZOHVL a causative agent of zoonotic

strengthening of our understanding of theの相互作用および抗ウイルス活性をもつ細胞性因

the molecular epidemiology of malaria parasites●毎年乾季になるとラッサ熱疑い患者が多数報告

子の機能解析を中心に研究を進めている。

されるナイジェリア南東部において疫学調査を行っinvestigating some fundamental aspects of●出血熱ウイルスやインフルエンザウイルスに対して抗ウイルス活性をもつ細胞性因子の同定及び化

in endemic countries, the biology of 3ODVPRGLXPYLYD[ hypnozoites, and the establishment of aている。また、疫学調査に基づいた新規診断法の開novel malaria model using ungulate 3ODVPRGLXP

発や病態発現機構の解析も進めている。
In addition, we are also conducting research
about the function and expression mechanism

合物のスクリーニングを行い、動物個体レベルで感of trans-sialidase and the stage specific

染・発症を抑制することができる新規抗ウイルス療

adaptation mechanisms of 7U\SDQRVPDFUX]L that

法の開発を進めている。
Fig.1 RBC invasion by P. yoelii . Merozoite-stage parasite(arrowhead) invades into RBC within 30 seconds (0 25 s) and deforms RBC to spike-like shape (85 s).

cause Chagas disease. Also we are investigating
the molecular basis of host cell invasion andmodification of %DEHVLD parasites that cause
Babesiosis in cattle and the development of genetic
manipulation techniques for piroplasm parasites

Fig.2 Colocalization of recombinant PkSBP1 protein (green) and
Giemsa-stained 'Sinton and Mulligan' stipplings in monkey
erythrocytes infected with PkSBP1-transgenic P. knowlesi .

05

of cytoadherence of parasite-infected RBCs.

●アルベルト・シュバイツアー博士ゆかりの地である中部アフリカのガボン共和国ランバレネにおいefforts, there is still no effective vaccine

basic biology of the parasite. We are currently

安田 二朗
Osamu
Kaneko助教
黒﨑 陽平
Assistant Professor
助
教
浦田
秀造
Kazuhide
YahataAssistant
助
教 Professor
阿部 遥
Masahito
Asada
助
教
櫻井 康晃
助
教
吉川 禄助

red blood cell (RBC) invasion and the phenomenon●エボラウイルス、マールブルグウイルス、ラッサウ
ルスなど重篤な疾患を引き起こすウイルスが宿主
implement effective disease intervention

Professor
教
授The department is designated as a WHO
Collaborating Center for Reference and Research on

various parts of the genes. We are currently

Takeshi Nabeshima

Department
新興感染症学分野
of Protozoology

Activities as a WHO Collaborating Centerand identified viral determinants by modifying

Assistant Professor

Microbiology
and病 原Parasitology
体解析部門

infectious diseases

1. Chitama et al. 3DUDVLWRO,QW 2019;71:186-193.
2. Kegawa et al. 3DUDVLWRO,QW 2018;67:706-714.
3. Asare et al. 3DUDVLWRO,QW 2018;67: 481-492.
4. Kaewthamasorn et al. 6FL5HS 2018;8:5827.
5. Asada et al. ,QW-3DUDVLWRO3DUDVLWHV:LOGO 2018;7:44-47.

Microbiology
and Parasitology

Department of Emerging
Infectious Diseases

We are working on the basic and applied research
to develop the countermeasures against emerging
infectious diseases, especially viral hemorrhagic fevers
and influenza.
Research subjects:
Analyses of replication mechanisms of highly pathogenic
viruses
In infected cells, the viruses replicate using various
cellular machinery and release a large number of progenyv i r i o n s . O u r intere s t s are to cla r i f y t he m olecula rmechanisms of virus replication in host cells. We are
currently analyzing the molecular interactions between
viral proteins and cellular factors in infected cells.
Especially, we are focusing on highly pathogenic viruses,
such as Ebola, Marburg, Lassa and Influenza viruses.
Development of novel antiviral strategies
To establish novel antiviral strategies against viralhemorrhagic fevers and influenza, we are identifying thecellular factors which have antiviral activity and analyzing
the molecular mechanisms of their antiviral action. We
are also doing high-throughput screening of organic andchemical compound libraries for antiviral drug discovery
against viral hemorrhagic fevers.
Development of detection methods for highly pathogenic
viruses
In case of outbreak of emerging infectious
diseases, rapid and accurate diagnoses are essential tocontrol infection and to prevent further transmission. We
have developed novel diagnostic assays for emerging
viral diseases.
Research studies on viral diseases in Gabon republic
T he fo l l owings are aims of t his p roje c t ; 1) toinvestigate prevalence of known and unidentified viraldiseases in Gabon through genetical and serologicalassays, 2) to determine characteristics including genetic
information and pathogenicit y of viruses which are
regarded as public health concern and those newly
identified in Gabon, and 3) to develop rapid diagnostic
methods for viral diseases of public health concern
and/or those newly identified;Professor

Jiro Yasuda
Professor

Asuka Nanbo
Assistant Professor

Yohei Kurosaki
Assistant Professor

Shuzo Urata
Assistant Professor

Research studies on Lassa fever in Nigeria
Lassa fever is a viral hemorrhagic fever and now
endemic in West African countries. Annually 300,000-500,000 peoples are infected with Lassa virus and 5,000
patients have died in Lassa fever every year. We arecarrying on the epidemiological studies, the developmentof novel diagnostic methods and the pathological studies
on Lassa fever in collaboration with a Nigerian group.

Haruka Abe

Ebolavirus and Epstein-Barr virus both cause major
infectious diseases in humans, such as Ebolavirus disease
and Epstein-Barr virus-associated malignancies,
respectively. The long-term goal of our study is to provide
insights into the molecular mechanisms of theirpathogenesis, which shall lead to the development ofrational therapies and diagnosis for them.
● Characterization of molecular mechanisms of EBOV
entr y and virus par ticle formation: toward thedevelopment of therapeutics for EBOV disease
Ebolavirus (EBOV), a member of the family -PSV]PYPKHL,
is an enveloped, single-stranded, negative-sense RNA virusthat causes severe hemorrhagic fever with a high mortality
rate , known as EBOV d iseas e ( E V D), in hu m a ns a n dnonhuman primates. Currently, no specific therapeutics has
been approved for treatment and prevention of EVD.
B e c a u s e o f t h e l i ke l i h o o d o f f u t u re o u t b re a ks a n dgeneration of mutant viruses, the development of a variety
of EBOV therapeutics is urgent. Our goal is to elucidate themechanism underlying virus entry and virion formation
process with a focus on host membrane traffic dynamics
and viral envelopeʼs constituent phospholipids (Fig.1). We
are also developing the therapeutics that specifically target
the entry and virion formation process in multiple ways,
which should lead to the significant contribution forprevention of EBOV infection in the future.
● Characterization of molecular mechanism ofdevelopment of EBV-associated epithelium tumors
Epstein - Barr virus (EBV ), a ubiquitous human γ-herpesvirus, establishes a persistent latent infection in B
lymphocytes and epithelial cells in more than 90% of adults
worldwide. Although this virus contributes causally tolymphomas and epithelial malignancies such as Burkittʼsl y m p h o m a , g a s t r ic c a rci n o m a , a n d nasopha r y n g ea lcarcinoma, the molecular mechanism by which EBV cause
these tumors remains fully elucidated. To update theunderstanding of the mechanisms for development of
EBV-associated epithelial tumors, we are elucidating thephysiological significance of exosomes, one t ype of
extracellular vesicles, released from EBV-infected cells intumor development. Moreover, we try to identify host andviral factors that are specifically and abundantly
i n c o r p o r a t e d i n exo s o m e s , wh i c h s h a l l l e a d t o t h edevelopment of potential biomarkers for EBV-associatedtumors that contribute to the diagnosis of these tumors. An
outline of this project is shown in Fig.2.

Assistant Professor

Yasuteru

Sakurai

Assistant Professor

Rokusuke Yoshikawa

1. Yoshikawa et al.-9LURO2019;93(10):e02226-18.
2. Pemba et al. -9LURO0HWKRGV 2019;269:30-37.
3. Oloniniyi et al. 3/261HJO7URS'LV 2018;12(11): e0006971.
4. Urata et al. 3/263DWKRJ 2018;14(7):e1007172.
5. Urata et al. %LRFKHP%LRSK\V5HV&RPPXQ 2018;503(2):631-636.

1. Nanbo et al. -,QIHFW'LV 2018;218(suppl̲5):S388-S396.
2. Nanbo et al. &DQFHUV2018;10(7):E237.
3. Nanbo et al. )URQW0LFURELRO 2018;9:984.
4. Nanbo et al. )URQW0LFURELRO 2018;9:454.
5. Nanbo et al. 3/263DWKRJ 2018;14(1):e1006848.

06Microbiology
and Parasitology

Department of
Parasitology

Various kinds of parasites infect humans
for long periods of time without killing them,giving rise to tremendous afflictions, social
and/or economic loss. We would like to develop
deep insight into parasitic diseases and thesurrounding factors from various points ofview through both field and laboratory studies.
Our goal is to contribute to new knowledge
and to provide an enthusiastic environment for
t he t raining of t he fu t u re generatio n ofinvestigators.
We have b e en researching parasitic
diseases in Mbita, Kenya, in cooperation with
Kenya Medical Research Institute (KEMRI) and
Maseno Universit y. In 2017, we have juststarted a new project on schistosomiasis withthe suppor t from ME X T Grant- in -Aid for
Scientific Research (A). We are also trying todevelop ideal diagnostic methods with thes u p p o r t f ro m G l o b a l H e a l t h I n n o v a t i ve

Professor

Shinjiro Hamano
Assistant Professor

Yoshinori Mitsui

Technology Fund (GHIT). In the laboratory, we
maintain :JOPZ[VZVTHTHUZVUP, its intermediate
host snail, )Y\NPHTHSH`P, )WHOHUNP and (LKLZHLN`W[P. Since 2017, we have been conducting“ D eWo r m 3 ” p roj e c t i n Ja pa n wh i ch i s
suppor ted by the Bill & Melinda Gates
Foundation as a collaboration with the Natural
History Museum, London.
We s tud y hos t defense mechanisms
against 3LPZOTHUPHspp, and in the process,have elucidated the function of the IL-12
cytokine family such as IL-27/WSX-1 during
infection. We have been developing the live
attenuated vaccine to leishmaniasis by editinga gene using CRISPR-Cas9 system with thesupport from GHIT since 2015. In addition, wedeveloped animal models of intestinal
amoebiasis together with Prof. Houpt atUniversit y of Virginia, we elucidate d thepathogenicity of ,U[HTVLIHTVZORV]ZRPP, andnow are devoting ourselves to the study onmolecular basis of pathogenicit y of ,
OPZ[VS`[PJH and host defense mechanisms to it.

Assistant Professor

Risa Nakamura
Technologist

Megumi Hamasaki

Host and Vector Biology

Department of
lmmunogenetics

Professor

Kenji Hirayama
Professor

Katsuyuki Yui
Lecturer

Mihoko Kikuchi
Assistant Professor

Dumre Shyam Prakash07

1. Moriyasu et al. 3/261HJO7URS'LV 2018;12(1):e0006197.
2. Deloer et al. 3DUDVLWRO,QW 2017;66(6):817-823.
3. Chadeka et al. 3/261HJO7URS'LV 2017;11(9):e0005872.
4. Mi-ichi et al. 3/263DWKRJ 2016;12(10):e1005845.
5. Kalenda et al. 3DUDVLWRO,QW 2015;64(6):503-512.

This department primarily focuses on thefundamental insights of the pathogenic genetic
factors of the host and the pathogens of tropicalinfectious diseases such as Dengue fever, malaria
and Chagas disease, through the application of
immunology and genetics. With the understanding of
the dynamic host-pathogen interactions, we arefurther concerned with the development of new
tools to fight against these diseases including novel
therapeutics (drugs) or vaccines.
We strive to build a highly interactive andcollaborative network for sustainable research
activities, and hence, we have various well-arranged
collaborative projects with the following overseas
and domestic facilities. 1) Research Institute forTropical Medicine (RITM), Philippines. 2) UAGRM,
Bolivia, 3) IICS University of Asuncion, Paraguay, 4)
Pasteur Institute in Ho Chi Minh City, and National
Institute of Hygiene and Epidemiology (NIHE),
Vietnam, 5) Ahmadu Bello University, Nigeria, 6)
Pasteur Paris, France, 7) London School of Hygiene
and Tropical Medicine, UK, 8) National Institutes of
Health (NIH), USA, 9) Tokyo Medical and Dental
University, 10) Toyama University, 11) The National
Institute of Advanced Industrial Science andTechnology (AIST)

Following ongoing research projects are going on.
1. Malaria
1) NGS analysis of Host and Malaria genome(KEKENHI)
2) Vaccine development (Shionogi)3) Anti-malarial drug development (AMED, Toyama)
2. Chagas disease
1) Early bio-markers identification for chronic
Chagas disease, namely, indeterminate, cardiac,and digestive forms in Bolivia (KAKENHI)
2) Host and parasite factors influencing on thereactivity to the chemotherapy (KAKENHI)
3) Exploring the essentiality of amastigote-stage
specific metabolic pathways in Trypanosoma
cruzi utilizing CPISPR/Cas9 system (GHIT)
4) Anti-trypanosomal drug development (Toyama,
Nagasaki)
3. Dengue1) Identification and validation of early stage
predictors for Severe Dengue (J-GRID).
2) Mechanism of cellular immunity on protection
against Dengue virus (J-GRID).

1. Phuong et al. $QQ&OLQ0LFURELRO$QWLPLFURE 2019;13;18(1):10.
2. Giang et al. 5HY0HG9LURO 2018;28(6):e2005.
3. Manh et al. -*HQ9LURO 2018;99(9):1239-1247.
4. Tani et al. -0HG&KHP 2018;61(14):6399.
5. Bui et al. -*HQ9LURO 2018;99(8):1044-1057.

1. Education and research
Aim of our department is to contributes u c h a s m i t o c h o n d r i al a n d b a c t e r i a l
respiratory chain and drug discovery anddevelopment targeting them.

Host and VectoｒBiology

to global health and welfare from basic

Department of HostDefense Biochemistryenergy metabolism, which is essential forhuman mitochondria, parasitic nematodest h e s u r v i v a l , c o n t i n u e d g r ow t h a n dsuch as (ZJHYPZZ\\T, parasitic protozoa

Our research has been focusing on

research. Main target of our research is

reproduction of living organisms. From the(7SHZTVKP\TMHSJPWHY\T;Y`WHUVZVTHIY\JLP

standpoint of biological adaptation, we;Y`WHUVZVTHJY\aP*Y`W[VZWVYPKP\T etc.)

have b e e n s t u d y i ng o n t he m o l e c u l a r
mechanism of energy transducing systems

Professor

Kiyoshi Kita
Bio-synthetic pathway of asucofuranone. (from Araki et al., PNAS, 2019)

1. Araki et al. 3URF1DWO$FDG6FL86$ 2019;116:8269-8274.
2. Pang et al. 1DW6WUXFW0RO%LRO 2019;26:289-296.
3. Matsubayashi et al. *HQHV2019;10(1):E29.
4. Sakamoto et al. 3DUDVLWRO,QW 2018;60:13-16.
5. Abalaka et al. 9HW3DUDVLWRO 2018;14:150-154.

We are a small, highly driven malariology
group focusing on many different aspects ofHost and VectoｒBiology

Department of
Pathology

Associate Professor

try to foster a freethinking and engaging research
environment for students working with us.

malaria. Established in 2011, we believe in a

We are interested in all aspects ofmulti-disciplinary approach to studying malaria,

malariology, and are currently actively engaged inas this enables a broad understanding of theresearch projects involving immunology,

subject, and therefore facilitates the development

genetics, genomics, evolutionary theory, ecology,

of novel solutions for fighting the disease.

epidemiology, and molecular cell biology.

Such a holistic approach to disease research

One particular ongoing project involves

can succeed only on the foundation of aanalysis of asymptomatic malaria carriage

solid and detailed understanding of its

inmulti-disciplinary constituents.

malaria researchers based in Japan and

Nigeria.

Collaborative

projects

with

Our core belief is that all our researchinternationally are of enormous importanceshould produce results that are of potential

to us, and make up the bulk of the work wepractical use for fighting the disease. We

are currently engaged in. At present wealso strive to engage young researchers inare actively working with researchers fromstudies on malaria, and hope to encourage

the USA, the Republic of Congo, Vietnam,

them to develop enthusiasm for useful scientificSriresearch. Research should be fun, and we

Nigeria, Brazil, the UK and Saudi Arabia.

Lanka,

Australia,

Tanzania,

Kenya,

Richard Culleton Leighton

1. de Alvarenga et al. 6FL5HS 2018;8(1):86.
2. Moriyasu et al. 3/261HJO7URS'LV 2018;12(1):e0006197.
3. Lu et al. 1(QJO-0HG 2017;376(10):991-993.
4. Abkallo et al. 3/263DWKRJ 2017;13(7):e1006447.
5. Brasil et al. /DQFHW*ORE+HDOWK 2017;5(10):e1038-e1046.

08

Public andEnvironmental Health

Department of
Eco-epidemiology

Professor

Satoshi Kaneko
Assistant Professor

Kentaro Kato
Assistant Professor

Tomonori Hoshi

Our department is involved in various
branches of public health research. With cuttingedge IT and biotechnology, we intend: to create
more accurate assessment methods in global
health, to improve responses to the publichealth needs on a local level, and to open new
directions in health sciences to the future
generations. Our activities include the following:1)Development of Microsphere-Based SimultaneousMultiple Assay System and Surveillance Systems forMultiple Infectious Diseases: Neglected tropicaldiseases (NTDs) are spreading across sub-SaharanAfrica, but the current assessment on NTDs is still
unclear. At the same time, simple and cost-effective
methods for monitoring NTDs are needed. To fillin this gap, we are developing a simultaneous
multiple antibody detection assay system, utilizing
microsphere-based multiplex technology andsampling system for the survey using the satellite
images to detect house structures with the
University of Tokyo.
2)Civil Registration and Vital Statistics (CRVS) for the
Epidemiological Research: In many developing
countries, CRVS systems are still deficient, and thisaffects the statistical analysis of the population in agiven region. For this, the resident registration
system for the epidemiological research in a given
location called Health and Demographic Surveillance
System (HDSS) was developed. HDSS follows
residents, and their dynamics over a long period. We
are operating HDSS programs to develop future
CRVS system integrating the cloud-based motherand child registration system in Kenya and Laos.
3)Epidemiological studies for the child health in
Kenya: The Kwale district in Kenya is one of thepoorest areas with high prevalence of stunted
growth. We are conducting epidemiological studies
to reveal the factors that could prevent stunted
growth.
4)Research to clarify the molecular bases of parasitic
diseases. Besides field work, basic research
especially on schistosomiasis, amoebiasis andleishmaniasis are being conducted in our lab. We arededicated to apply our achievements from the lab tothe field.
5) Research on monkey malaria vectors applying the
3D-printing technology-based original mosquito
trap: We are working in northern Borneo incollaboration with research teams in the UK and
University Malaysia Sabah.
1. Hitachi et al. ,QW%UHDVWIHHG- 2019;14:32.
2. Hoshi et al. 6FL5HS 2019;9(1):11412.
3. Tanaka et al. 3XEOLF+HDOWK 2019;173 58.
4. Shimazaki et al. ,QW-7XEHUF/XQJ'LV 2018;22(1):65-72.
5. Sato et al. ,QW-(QYLURQ5HV3XEOLF+HDOWK 2019;16(16):E2954.

Public andEnvironmental Health

Department of International
Health and Medical Anthropology

Professor

Taro Yamamoto

Department of International Healthperception, our department aims to get

and Medical Anthropology has started its

more detailed understanding and insight on

activities since 2008.

infectious diseases. We would like to pursue

Our research was composed of four

the ways of analysis by various approaches

units; 1) research on infectious diseases insuch as molecular-evolutional technique,ecosystem, 2) research on the environment

molecular epidemiology, detection of trace

health, 3) research on biological evolution

DNA, genomics based on bioinformatics,

of microorganisms from the adaptation ormathematical model, and computer science.

fitness viewpoint and 4) research on the

Another pillar of our department is a

epidemiology from the historical viewpoint.

social responsibility. Now that even profit

The umbrella concept linking above fouroriented organizations are required to haveresearch units is to reconstruct infectious

its corporate social responsibility, no needdiseases "temporally" and "spatially" alike.

to say for academia or university. Out of

Infection is the biological phenomenon as an

the name of our department, it must be

interaction between hosts and microorganisms.

nothing but contribution to international

In other words, host behavior, social structure

health or people's health in resource-limited

as well as culture per se affect microorganisms insettings. What we think of important isfitness and adaptation whereas microorganism

to make solidarity in order to contributehas impact on its hosts. Based on thatto sustainable

development. It is ourdepartment's goal.

Associate Professor

Takayuki Wada
Assistant Professor

Hiromu Ito

1. Ito et al. $SSO0DWK&RPSXW 2019;348: 363-370.
2. Yamamoto et al. ,QIHFW*HQHW(YRO 2019;72:25-30.
3. Koirala et al. -3K\VLRO$QWKURSRO 2018;37:20.
4. Yoshida et al. (PHUJ,QIHFW'LV 2018;10:1937-1940.
5. Tu et al. *HULDWU*HURQWRO,QW 2018;18:1093-1099.

09Public andEnvironmental Health

Department of Global Health
Development Policy Sciences

Department of International Health Development Policy (former Department of Social Environment) was
re-established in 2018 by inviting three concurrent professors from the School of Tropical Medicine and Global
Health (TMGH). The three professors have expertise of nutrition and epidemiology (S. Cox), pediatrics anddevelopment assistance (Y. Kamiya), and human ecology and ecohealth (K. Moji). The department promotes policy
researches in various global health fields for making critical evaluation and constructive proposal for health policy.

Nutrition and Infectious diseases
I a m i n t e r e s t e d i n h ow n u t r i t i o nunderpins human health and in particular
in relation to interactions with infections,other conditions like sickle cell disease andmaternal and child health. My researcha i m s to p rov i d e a n ev i d e n c e b a s e t osupport nutrition-based interventions toimprove health outcomes in populations in
low and middle income countries. Current
work is largely focused on Tuberculosis inwhich I am leading research on nutritionand diabetes in TB patients in thePhilippines in both inpatient and outpatient
populations. I collaborate withinvestigators from San Lazaro Hospital,
Manila, the Nutrition Centre of thePhilippines and the National TB
programme. Other recent researchi n c l u d e s : a c o l l a b o r a t i o n wi t h Ac t i o n
Against Hunger to evaluate community
based malnutrition diagnosis and referral
within integrated community case based
management programme (iCCM) in
Burundi; malnutrition in pediatricadmissions in Nepal and investigating thedeterminants of malnutrition of young
children within the NHAM birth cohort inCambodia (National Centre for Global
Health, Japan), with a focus on infections
and the microbiome.
1. Lee et al. 3/2621( 2019;14(6):e0218193.
2. White et al. 3/2621( 2019;14(5):e0215968.
3. Lee et al. (%LR0HGLFLQH 2018; 34:158-164.
4. Cox et al. /DQFHW+HPDWRO 2018;5(4):e147-e160.
5. Shridhar et al. &XUU'HY1XWU 2018;3(3):nzy085.

TB ward at San Lazaro Hospital, Manila

Implementation Science in Health and Disability

Professor

Sharon Cox
Professor

Yasuhiko Kamiya
Professor

Kazuhiko Moji

My support and study is focused on redressing healthdisparity in low- and middle-income countries. Notwithstanding
global evidence-based aid and national policy, health disparity
h a s b e e n w i d e n i n g w i t h k n ow - d o g a p a n d m i s m a t c h(coexistence of excess and deficiency) in health service delivery
due to organizational path dependency, lack of coordination,
vertical silo of programs and aid fragmentation. Just attributing
health disparity to lack of access to, and low supply of healthcare can mislead and delay its fundamental problems. ThroughImplementation Science applying to international cooperation
for maternal and child health, support for disabled children andnon-communicable diseases, and emergency humanitarianassistance, my assistance and research facilitate local staff andpeople identify bottlenecks and barrier to strengthen healthsystems and governance based on bottom-up problem-solving.

Social determinants of health disparities have been
revealed through studies of social epidemiology since thelate 20th Century. Health impacts of global climate change
as well as global (and local) environmental changes haveTraining for Community Health Workers in Honduras

1. Kodaira et al. -,QW+HDOWK 2019;34(1):19-25.
2. Tsukakoshi et al. 9LURO-2015;12:36.
3. Sasaki et al. -7URS3HGLDWU 2015;61(1):14-19.
4. Sato et al. %0&+HDOWK6HUY5HV 2014;14:123.
5. Masumoto et al. ,QW-7XEHUF/XQJ'LV 2014;18(2):174-179.

been revealed almost simultaneously. To integrate all thefactors related to our health, human ecological systemthinking, or “ecohealth” thinking is indispensable. For global
health (or international health development) policy, not only
improvement of medical services but also health promotion
and disease prevention by means of better hygiene and safer
and healthier lifestyle and non-medical care and social
supports should be collectively implemented. Health policy isbeyond the narrow medical policy. This department will
promote researches on evaluation of health policy on
population health for better policy proposal.
1. Pongvongsa et al. 7URS0HG+HDOWK 2018;46:33.
2. Sato et al. 3/261HJO7URS'LV 2018;12(2):e0006260.
3. Hashizume et al. $FWD7URS 2017;169:1-7.
4. Pongvongsa et al. 0DODU- 2016;15(1):508.
5. Feldmeier et al. 7URS0HG+HDOWK 2016;44:12.

10

Public andEnvironmental Health

Department of Vector
Ecology and Environment

Our research interests include

populations. The results suggest that the

any thing from ecology to molecularm o s q u i to p o p u la t i o ns in t he e ndemic

biology of medically important arthropods,

areas were introduced from the overseas.

par ticularly mosquitoes that transmit

To test the hypothesis fur ther, we arepathogens such as Malaria parasites andcurrently conducting various studies,dengue virus in Africa and Southeast Asia.

including a study on virus susceptibility.

We are also interested in their relationships

Fo r re d u c i ng m a l a r i a r i s k , we a rewith environmental variables andstudying t he ef fectiveness of new

development of environmentally friendly

insecticides and insecticide treatedvector control tools.

mosquito nets (ITNs) in Kenya and Malawi.

For an important dengue virus vector,

We are also developing a malaria early

we revealed the geographical distributions

warning system in Africa, incorporatingof two subspecies of (LKLZHLN`W[P in East

climate predictions.

and South African regions. Our study also
found that the genetic structure of(LHLN`W[PWVW\SH[PVUZ in endemic areas inProfessor

Africa is similar to those of Southeastern

Noboru Minakawa
Associate Professor

Hitoshi Kawada
Assistant Professor

Toshihiko Sunahara
Assistant Professor

1. Yamamoto et al. %LRVHQV%LRHOHFWURQ 2019;132:375-381.
2. Kasai et al. (XUR6XUYHLOO 2019;24(5). doi:10.2807/15607917.ES.2019.24.5.1700847.
3. Tamari et al. 3DUDVLWRORJ\2018;146(3):363-371.
4. Imanishi et al. -SQ-,QIHFW'LV 2018;71(6):427-435.
5. Behera et al. (QYLURQ'HY 2018;27:47-57.

Kyoko Futami
Assistant Professor

Takashi Tsunoda
Assistant Professor

Hu Jinping

Clinical Medicine
and Research

Department of Clinical
Product Development

Professor

Juntra Laothavorn
Assistant Professor

Chisato NaraharaThis is a newly established department inresponse to the Global Strategy on public health,innovation and intellectual property (resolution
WHA61.21). The resolution calls for the enhancementof health-needs driven research and development
to address diseases that disproportionately
affect developing countries. The establishmentof this department was supported by the Departmentof Academic and Research Promotion, Ministryof Education, Culture, Sports, Science andTechnology (MEXT), Japan. MEXT continues tosupport the department until its full development.
The department focuses on:
1. Building capacity of individuals for innovationin health product2. Strengthening capability of the local research
institutions
inprovidinganenabling
environment, including infrastructure for
product R&D
3. Strengthening research institutes network forknowledge sharing and exchange, and for
R&D technology transfer activities. The
emphasis will be on developing products for
public health needs to address the issues ofinequity in health.
4. Filling the gap of health knowledge
The activities:
1. Training
1)Two- week course on Product Research andDevelopment for public health needs;
2)Three-day course on Bioethics3)Responsible research
2. Research
1)Identification and further development of
Herbal Medicine and novel small compounds
for Breast cancer, Cholangiocarcinoma andMalaria2)Validating the Enhance Informed Consent forclinical trials.
3)Host pharmacogenomics and malaria virulence.
4) Revolution of P.falciparum K13 in Thailand.
3. Network
1)Coordination of Product Research andDevelopment (PRD) Network
2)Coordination of research ethics global
network: Strategic Initiative for Developing
Capacity in Ethical Review

1. Saeheng et al. (XU-&OLQ3KDUPDFRO 2018;74(11):1365-1376.
2. Juntra et al. %0&0HG(WKLFV 2018;19(1):79.
3. Koonrungsesomboon et al. $UFK'LV&KLOG)HWDO1HRQDWDO
(G 2018;103(5):F403-F407.
4. Emmanuel et al. $QQ&OLQ0LFURELRO$QWLPLFURE 2018;17(1):35.
5. Na-Bangchang et al. (YLG%DVHG&RPSOHPHQW$OWHUQDW0HG
2017;2017:5929234.

11

Clinical Medicine
and Research

Department ofClinical Medicine

Koya Ariyoshi
Chris Smith
Associate Professor Konosuke Morimoto
Assistant Professor Yoshiro Yamashita
Assistant Professor Eiichiro Sando

This is the only clinical department in NEKKEN clinical in
Nagasaki University Hospital. We conduct a wide range ofmulti-disciplinary studies our strength of clinical epidemiology
to laboratory-based microbiology and immunology both in- andoutside Japan. Our main research interests are respiratory
infectious diseases, tropical infectious diseases, tuberculosis(TB) and HIV/AIDS. Specific research topics are as described
below:
1. Respiratory Infections Diseases
We apply our in-house multiplex-PCR assays to identify 19
different viral and bacterial respiratory pathogens and a novel
nano-fluidic real-time PCR-based assay to determine 50
pneumococcus serotypes for a multi-center adult pneumonia
survey all over Japan and childhood acute respiratory infection
study in central Vietnam. We published several papers
demonstrating vaccine efficacy against pneumococcal
pneumonia and influenza. Since 2009, we have run a birthcohort study of about 2,000 pairs of mothers and new-bornbabies, which facilitates studies of host- gene factors
associating the severity of pediatric infectious diseases.

2. Tuberculosis
For bet ter- diagnosis of latent MTB infection andtuberculosis, we are analyzing cellular immune responses tovarious TB antigens using an intra-cellular cytokine staining
assay to evaluate a range of cytokines profile in various stages
of TB infection and their contact cases. Our goal is to clarify
TB-specific cellular immune responses characteristic to adifferent clinical stage of TB infection. We also investigatedpathogens causing bacterial pneumonia and its impact on thesurvival prognosis of TB patients admitted to the National
Infectious Diseases Hospital (San Lazaro Hospital) in thePhilippines.
3. Fever management in the tropics
We are conducting undiagnosed febrile illness study in the
Department of Infectious Diseases, Bac Mai Hospital, Hanoi,
Vietnam and the National Infectious Disease Hospital (San Lazaro
Hospital), the Philippines, by applying diagnostic tests for
leptospirosis and various richettial diseases. We also coordinate a
bed-side clinical training course in tropical medicine.
4. HIV/AIDS Studies
In collaboration with National Institute of Health, Thailand,
Bac Mai Hospital, Vietnam, Philippine General Hospital, andNagoya Medical Center, we have investigated the pattern ofopportunistic infections among HIV/AIDS patients and disclosed
different clinical pictures in different geographical settings.

Professor
Professor

The University Hospital
Infectious Disease Ward

Bed-side clinical training course in San Lazaro Hospital

The clinical department of the Instituteo f Tr o p i c a l M e d i c i n e ( N E K K E N ) wa s
established in the Nagasaki Universit yHospital in 1967 and it has been locallyknown as “NEKKEN-NAIKA”. Currently itruns an out-patient clinic twice a week as
the Department of Infectious Diseases andprovides in - patients care in a generalinternal medicine ward with 16 beds and a
TB ward with 6 beds.
We a r e s p e c i a l i z e d i n i n f e c t i o u s
diseases; we treat patients with systemic
infectious diseases, including tropicalinfectious diseases, HIV/AIDS, tuberculosis,
pneumonia, and other febrile cases. We
receive approximately 500 - 600
consultation cases with suspected
infectious diseases a year from other

1. Saito et al. &OLQ,QIHFW'LV 2018;67: 897-904.
2. Kakiuchia et al. -&OLQ0LFURELRO 2018;25: e01874-17.
3. Sando et al. (PHUJ,QIHFW'LV 2018;24:1633-1641.
4. Mori et al. -$FTXLU,PPXQH'HILF6\QGU 2018;78:356-361.
5. Shimazaki et al. ,QW-7XEHUF/XQJ'LV 2018;22:65-72.

wa rds . We a l s o r u n a t rave l cli n ic fo rinternational travelers.
For training and education, we provide
a number of lectures on infectious
diseases to undergraduate students andbed-side training programs for resident
physicians and infectious disease fellows.
We organize a clinical case conference inEnglish to make Japanese doctors
prepared to work abroad. Staff doctors
and resident doctors are regularly
dispatched to hospitals in the tropics suchas San Lazao Hospital, the Philippines andthe infectious disease ward in Bac Mai
Hospital, Vietnam, MRC hospital in The
Gambia, West Africa. That helps us toaccumulate our knowledge and experience
with clinical tropical medicine.

Professor

Koya Ariyoshi
Associate Professor

Konosuke Morimoto
Senior Lecturer

Hirotomo Yamanashi
Assistant Professor

Kensuke Takahashi
Assistant Professor

Mai Izumida

Assistant Professor

Kousuke MatsuiGroup photo of staff members

12Clinical Medicine
and Research

Department of Pediatric
Infectious Diseases

Environmental epidemiology:
health impacts of cliamte change

Clinical Epidemiological Studies of Pediatric
Infectious Disease in Nha Trang, Vietnam

Our research interests extend over a range ofissues in environmental epidemiology. The current
research topics, which we work in collaboration withboth the international and Japanese colleagues,
focus mainly on the health impacts of atmosphericenvironmental changes including climate variability,
global climate change and transboundary and local
air pollution in high-, middle- and low-income
countries. Ongoing projects include:

The Department of Pediatric Infectious Diseases
conducts research on a wide range of infectious
diseases with special attention on severe pediatricinfectious diseases including pneumonia, diarrhea, anddengue which are the major causes of under 5 mortality.

1. Short-term association between ambient temperature(heat, heat extremes and cold) and mortality inJapan and other parts of the world.
2. Effects of ocean-atmosphere interaction phenomenon
and local weather on vector-born, water-born andother infectious diseases in tropical andsub-tropical settings.
3. Development of malaria early warning system inSouthern Africa
4. Health effects of local and transboundar y air
pollution in Japan and in the East and Southeast Asia.
5. Respiratory health effects of the different chemicalcomposition of airborne particulate matter andthe sources.

Professor

Masahiro Hashizume
Professor

Lay Myint Yoshida
Assistant Professor

Michiko Toizumi
Assistant Professor

Mizuki Takegata
Assistant Professor

Keisuke Yoshihara
Assistant Professor

Lina Madaniyazi
Assistant Professor

Mohammad Shah

1. Cohort studies on Pediatric Infectious Diseases inVietnam: We receive funding from the Japan
Initiative for Global Research Network on
Infectious Diseases (JGRID), Japan Agency for
Medical Research and Development (AMED) to
conduct a large population based cohort study on
Pediatric Infectious Diseases in Nha Trang, central
Vietnam since 2006.
2. Pediatric ARI sur veillance: A population based
hospitalized Pediatric ARI surveillance at Khanh
Hoa General Hospital, Nha-Trang, Vietnam wasestablished to determine incidence, etiology andrisk factors for pediatric ARI/pneumonia since2007. We also investigate the emergence of new
viruses and its molecular and clinical importance.
In addition, we also investigate the impact or
potential of various vaccine introduction on
pneumonia and dengue in a population level.
3. Birth cohort study: We are also conducting a birthcohort study on 2000 new born babies in Nha Trang,
Vietnam since 2009. This study was conducted to
study congenital infection and host genetic factors
on physical-neurological development of the childand development of SPID.
4. Pneumococcal conjugate vaccine (PCV) reduced
dosing trial: We received a multimillion dollar grantfrom Bill and Melinda Gates Foundation to conduct a
PCV reduce dosing trial in Vietnam. We believe thatthe study outcome will change global PCV vaccination
strategy to improve the availability of PCV and othervaccines in developing countries.
5. Dengue intra-family transmission in the community:
In collaboration with London School of Hygiene
and Tropical Medicine, we are conduction adengue intra-family transmission study in thecommunity in Nha Trang. We identify dengue
index cases by screening fever cases and followed
up their family members for dengue transmission.
We also conduct community IgG/M dengue survey
in the community to determine yearly dengue
infection in the community. These data will be
used for future intervention studies to control
dengue in the community.

Immunization with Pneumococcal
Conjugate Vaccine

At Pasteur Institute Nha Trang

1. Chung et al. (QYLURQ+HDOWK3HUVSHFW 2018;126(5):057002.
2. Matsushita et al. 3/261HJO7URS'LV 2018;12(4):e0006331.
3. Kim et al. (QYLURQ+HDOWK3HUVSHFW 2018;126(3):037002.
4. Kim et al. (QYLURQ+HDOWK3HUVSHFW 2017;125(7):077005.
5. Gasparrini et al. /DQFHW 2015;386(9991):369‒375.

13

1. Do et al. -SQ-,QIHFW'LV 2017;70(6):621-627.
2. Shi et al. /DQFHW 2017;390(10098):946-958.
3. Yoshihara et al. 6FL5HS2016;16;6:27856.
4. Flasche et al. 9DFFLQH2014;32(51):6963-6970.
5. Toizumi et al. 3HGLDWULFV2014;134(2):e519-26.

Shionogi Global
Infectious Diseases

Department of Cellular
Architecture Studies

1. Shionogi Global Infectious Diseases Divisiona l l ows u s to f i n d i m p o r t a n t i n fo r m a t i o n to

Shionogi Global Infectious Diseases Division

molecular factors that are involved in ʻintelligent

was established in April 2019, through theinterior designʼ by parasites, and aim to find newcollaboration agreement between Shionogi &antimalarial drug targets and compounds which

discover a new drug target .

We searchCo., LTD. and Nagasaki University to tackle

p reve nt s t rans i t i o n to se r ve r m a l a r i a . O u rmalaria.

Four laboratories, Departments ofre s e a rc h h a s b e e n m e rg i n g a d va n t a g e s o f

Cellular Architecture Studies, Molecular Infection

classica l b i o c h e m i s tr y/cellula r b i o l o g y andDynamics, Immune Regulation, and Exploratory

biophysical approaches . High - resolution

Research for Drug Discovery get together in thei m a g i n g , l i p i d o m i c s , p r o t e i n c h e m i s t r y,same laboratory space and team up for our

high-throughput screening for inhibitor

mission to find new drug and vaccine candidates

compounds have been actively used to achieve

by taking advantages of expertise from eachour goal. We share our data and collaborate

department. This is the unique but powerful

wi t h o t h e r t h r e e l a b o r a to r i e s fo r a d v a n c ecollaborationthat

expandsourscientificexperiments for for tif ying our scientificcompetence.

potential and flexibility.
2. Research Activity
Blood stage of malaria parasite invades
human erythrocytes and proliferates by creating
Professor

Fuyuki Tokumasu
Guest Researcher

Ryuta Ishii

Guest Researcher

Satoshi Miyagawa

i t s own c e l l u l a r e nv i ro n m e n t . T h is p ro c e s s
includes fo r mations of co m p l ex m e m b rane
structures inside er y throcy te cytoplasm andtranspor tations of parasite proteins toerythrocyte membrane. Studying this host cellMHSJPWHY\T research, that often induces severmolecular mechanisms of structural andchemical balance of parasitized erythrocytes

Department of Molecular
Infection Dynamics

感染後まもなく赤血球細胞に大小様々な膜形成が起こり始める。

modifications is essential in 7SHZTVKP\T
forms of malaria. We believe that unveiling theShionogi Global
Infectious Diseases

感染細胞内に形成される複雑な膜構造。

1. Balogun et al. %LRFKLP%LRSK\V$FWD*HQ6XEM 2017;1861(11Pt A):2830-2842.
2. Shindou et al. -%LRO&KHP 2017;292:12054-12064.
3. Tokumasu et al. %LRO2SHQ 2014;3:529-541.
4. Tokumasu et al. ([S3DUDVLWRO2012;131:245-251.

The Department of Molecular Infection

Intestinal parasites have evolved sophisticatedDynamics, in cooperation with Department ofmachinery to adapt and survive in hypoxic

Exploratory Research for Drug Discovery aim toandidentify drug target molecules and to establish(microenvironment). Certain type of cancer

screening systems in order to find leadcells

compounds with potential use for treatment,

survive under tumor microenvironment.

prophylaxis and transmission blocking against
malaria.

nutrient
also

deprived

possess

similarenvironment
machineryto

Our activities are supported by research
grantsacquired

from

KAKENHI(MEXT),

AMED, GHIT and Private Companies.
This Department conduct research on
microaerophilic

metabolism

conserved

inseveral pathogens such as parasites (protozoa
and helminth) and bacteria, in order tounderstandthemolecular mechanism ofparasitism phenomena.
We utilize multidisciplinary approaches,
consisted by biochemistry, molecular biology,
biophysics, structural biology and chemical
biology, to conduct our basic and applied
Associate Professor

Daniel Ken Inaoka
Assistant Professor

Takaya Sakura

research.
Our target infectious diseases include
protozoan parasites such as 7SHZTVKP\T spp.,;OLPSLYPH spp., ;Y`WHUVZVTHJY\aP, ;IY\JLPand
3LPZOTHUPH spp.; helminthes such as (ZJHYPZ
Z\\T, (UPZHRPZ spp., /HLTVUJO\ZJVU[VY[\Z and-HZJPVSHspp., and bacterial pathogens suchas 4`JVIHJ[LYP\Tspp、and /LSPJVIHJ[LYW`SVYPWe also conduct research on cancer.

1. Araki et.al. 3URF1DWO$FDG6FL86$ 2019;116(17):8269-8274.
2. Shiba et.al. %LRFKLP%LRSK\V$FWD%LRHQHUJ 2019;1860(5):375-382.
3. Matsubayashi et.al. *HQHV2019;10(1):E29.
4. Miyazaki et.al. )URQW3KDUPDFRO 2018;9:997.
5. Ebiloma et.al. (XU-0HG&KHP 2018;150: 385-402.

14

Shionogi Global
Infectious Diseases

Department of
Immune Regulation

Our scope is the analysis of the humanFirst , our study will use mouse malaria

immune response against malaria, especiallymodel, and aim to apply our research finding for

relate to malaria vaccine development.

human malaria especially for 7MHSJPWHY\T.

We

hope our study will contribute to developing a

The life cycle in human body of thebetter malarial vaccine candidate.

protozoan parasite 7SHZTVKP\T, responsible ofmalaria, is divided into two stages; erythrocytic-

and liver- stage. Even with argent appearance ofdrug resistant strain, there are many current
antimalarial drugs available for the erythrocytic
stage. On the other hand, for the liver-stage,
there are few drugs available with undesirable
side effects, thus vaccine and drug development
are still an urgent issue for this stage.
Cellular immuni t y including cy totoxic T
lymphocytes (CTL) is considered essential for
protection against liver stage malaria. But many
vaccine development aim to induce neutralizing
a n t i b o d y, t h e m a i n

ef fector of humoral

immunity, and cellular immunity has not been
Associate Professor

Shusaku Mizukami

considered enough.
T h e refo re , we fo c u s o n t h e l i ve r s t a g emalaria as the target for our cellular immunityb a s e d va c c i ne d eve l o p m e n t . O u r p la n is to
examine and optimize: a. vaccine antigen whichlead the protection by cellular immunity, b. thetargeted antigen delivery system c. the adjuvant
and route of administration to enhance immune
response.

Malaria is one of the three largest infectious
diseases in the world, which aligns with HIV andShionogi Global
Infectious Diseases

Department of Exploratory
Research for Drug Discovery

tuberculosis. More than 200 million people are

1. Phuong et al. $QQ&OLQ0LFURELRO$QWLPLFUREH 2019;18(1):10.
2. Manh et al. -*HQ9LRO 2018;99(9):1239-1247.
3. Tani et al. -0HG&KHP 2018;61(14):6399.
4. Inokuchi et al. $UFK9LRO 2018;163(9):2337-2347.
5. Mosaddeque et al. $QWLPLFURE$JHQWV&KHPRWKHU 2018;62(5):e02424-17.

within Shionogi■ C o n d u c t i n g t a rg e t d i s c ove r y a n d b a s i cresearch for antimalarial drugs

infected with malaria and more than 400,000
people died annually. There has b een still noeffective vaccine, and resistant malaria to existing
therapeutic drugs have been reported, and thedevelopment of new drugs is urgently necessary.
In this department, a Shionogiʼs researcheri s i n c h a r g e o f p r i n c i p a l i nve s t i g a t o r, a n d
together with the three departments in SHINE
division. We will take on the role of hubs thatconnect research assets such as know-how andglobal network of malaria research, which aret h e s t re n g t h s o f N a g a s a k i U n i ve r s i t y, a n dscreening drug discover y utilizing the small
molecule SAR (structure-activity relationship)
engine, which is the strengths of Shionogi, topromote the discover y research of n ew
therapeutic drugs by taking advantage of eachstrengths. Especially, the purpose is to create a

Visiting Associate Professor

Teruhisa Kato

(Head of Exploratory Drug Discovery
for Infectious Diseases, SHIONOGI &CO., LTD.)t h e ra p e u t i c d r u g wi t h s t ro n g a n t i m a l a r i a lactivity and high safety with the department of
Molecular Infection Dynamics.
Research activities are as follows:■ Promotion of drug discover y research on
screening-based drug discovery■ Implementation of Hit to Lead Structure-Activity
Relationship (SAR), and creating lead scaffolds■ Optimization of drug metabolism, safety, andphysical parameters of candidate compounds

15

1. Ryckmans et al. %LRRUJ0HG&KHP/HWW 2011;21:4857-4859.
2. Mori et al. -3KDUPDFRO([S7KHU 2009;328:671-679.

Center for Infectious Disease
Research in Asia and Africa

Kenya Research
StationChief Representative, Professor

Satoshi Kaneko

Nagasaki University Institute of Tropicaldiagnostics, and the establishment of an alert

Medicine and Kenya Medical Research Institutesystem for the outbreak of Yellow Fever and Rift

(NUITM-KEMRI) Project was launched by signing

Valley Fever were achieved and completed in

the Memorandum of Understanding between

2017.

the President of NUITM, and the Director ofsurveillance

AMED-funded

KEMRI in 2005. The objective of the project was(NTDs) is now on the 3rd phase of the project.

to enhance research and to develop capacity

Additionally, research activities are funded
the

on

JSPS

project

neglected(KAKEN),for

serologicaltropicalthediseasesbuilding in the tropical medicine at the field level.

by

In January 2006, Kenya Research Station wascompanies, and the Grand Challenge Canada

pharmaceuticalestablished to manage the project. Biosafetythat supports the development of mother andLevel 2 and 3 laboratories, and insectary forchild registration system.

mosquitos were installed in the station. Research

Furthermore, we began a JICA Grass-root

field sites were also established in Mbita near

project focusing on community development

the Lake Victoria, and in Kwale on the coast sideand school health in Mbita since 2009, as meansof Kenya. Health and Demographic Surveillance

for the feedback to the communities.

System (HDSS) has registered the population of

In terms of education and training, theabout 120,000 people in the field, as well as

station is accepting Masterʼs and PhD students

vital events like birth, death and migration infrom the Graduate School of Tropical Medicine

two

Mosquitoand Global Health, and the Graduate School ofSurveillance System (MSS) has been functional

Biomedical Sciences at Nagasaki University. The

for research on malarial mosquitos in Mbita.

station is also providing research opportunities

researchareas.

Additionally,

Regarding the research activities based at
the station: Basic research teams are organized

for

young

researchers,

andstudents from

Kenyan institutions.

according to the external research grants orfunds. Until now, the SATREPS Project for rapid

1. Takeuchi et al. 3/261HJO7URS'LV 2019;13(8):e0007572.
2. Shah et al. $P-7URS0HG+\J 2019;101:290-293.
3. Shah et al. $P-7URS0HG+\J 2019;100:688-690.
4. Wandera et al. ,QIHFW*HQHW(YRO 2018;68:231-248.
5. Shah et al. 7URS0HG+HDOWK 2018;46:30.

Center for Infectious Disease
Research in Asia and Africa

Vietnam Research
Station

Since 2015, Japan Initiative for Global ResearchTrang sub-station by a permanent staff of 2 people, in

Network on Infectious Diseases (J-GRID) project has

addition to which 6 staff from NU and a further 64

been taken over to the newly established Japan

researchers from other research institutions participate

Agency for Medical Research and Developmentin the activities of the Station and conduct research.

(AMED) and J- GRID project Phase 3 is currently

The Vietnam Research Station has been conducting

underway. The 4 main research subjects are dengue

educational support as an early exposure facility in the

fever, infectious diarrhea, influenza, and drug-resistantProgram for Nurturing Global Leaders in Tropical andbacteria, and also severe childhood pneumonia,

Emerging Communicable Diseases that was launched in

HIV/AIDS and tuberculosis are included to study to

2015. Furthermore, the Station is also utilized as ancontribute to prevention of infectious diseases

on-the-job-training facility for other researchers notcollaboration with National Center for Global Healthjust from NU. In 2017 the Station was visited by 3

and Medicine, Research Institute of Tuberculosis,

undergraduate universit y students, 4 graduate

Tottori University, Kyoto Sangyo University, and thestudents, 4 high school students and 8 administrative

Kitasato Institute. Furthermore, every year an open

staffs from NU, through which a wide diversity oflecture on infectious diseases has been held forhuman resource fostering activities were conducted.

Japanese residents in Vietnam as outreach activity. In

In 2018, 2 staff members of NIHE were graduatedthe year 2018, the 11th open lecture was held. Prof.

from the doctoral course in Nagasaki University andIchiro Nakagawa (Kyoto University) and Prof. Jiro

received PhD in molecular epidemiological study of

Yasuda (Nagasaki University, NU) were invited andVibrio cholerae.

gave lecture for drug resistant bacteria and Ebola virus
infection measures respectively.
The Vietnam Research Station in the National
Institute of Hygiene and Epidemiology (NIHE) in Hanoi is
Chief Representative, Professor

Futoshi Hasebe

currently manned by 4 staffs from NU, and the Nha

Assistant Professor

Taichiro Takemura

A lecture for high school students as Super
Global High School's program.

1. Okada et al. 6FL5HS 2018;8(1):1631.
2. Obana et al. -9HW0HG6FL 2017;79(1):76-81.
3. Nguyen et al. 7UDQV56RF7URS0HG+\J 2017;111(3):137-139.
4. Moi et al. /DQFHW,QIHFW'LV 2017;17(8):805-806.
5. Ngwe Tun et al. -SQ-,QIHFW'LV 2017;70(4):357-361.
NIHE-NU scientific symposium at Nagasaki University, 2018.

16

Associated Facility

Tropical Medicine
MuseumI n A p r i l 2014 , t h e M u s e u m o f Tro p i c a lTropical Medicine: There are sections providing

Medicine moved to the Atomic Bomb Disease

information on tropical diseases, parasites,

I n s t i t u te Building N o. 2 , and ex pa n d e d t hebacteria, virus, insects (vectors), specimen of

exhibition area. The exhibition is divide into

dangerous animals, audio-visual materials andc a t e g o r i e s o f ʻ P r o l o g u e ʼ, ʻ P a r a s i t o l o g y ʼ,

documents. The audio-visual corner demonstrates

ʻBacteriologyʼ, ʻVirology.ʼ It provides information oninteresting scientific movies with 80-inch screen.

Tropical Infectious Diseases by using 80 panels,

There are more than thousands of data/resource

microscopic images, movies, educational models

collections.

and specimens. A lthoug h main v isitors are

2.IT infrastructure maintenance: Network tools

Japanese, quite a few people visit from overseas.

and ser vers are updated with technological

For these foreigners English translated panels areinnovation and maintaining its security. The

installed in i - Pads and lend them when it isrenewal of IT infrastructure in 2018 strengthened

requested. In addition to the contents on tropical

VPN and data backup system. It provides safe andinfectious diseases, a corner expounding on

secure it environment to researchers work at

Biosafety Level-4 (BSL-4) laboratory contributes

NEKKEN and the overseas research stations in

to advocating on the needs, safety and security.
The section of Museum of Tropical Medicine
mainly performs the following 3 functions.
Professor

1.Function as a museum and resource center on

Kenya and Vietnam.
3 . Re s e a rc h: P ro f. O kumura condu c t s f i e ld
research in Lao PDR and Republic of Guinea. She
collects epidemiological data on infectious
diseases, health seeking behavior, nutrition etc. in

Junko Okumura

order to identify factors affect child health.

Technologist

Kazuo Araki

1. Okumura et al. -,QWO+HDOWK 2019;34(1):35-43.
2. Delamou et al. /DQFHW*ORE+HDOWK 2017;5(4):e448-e457.
3. Camara et al. 7UDQV56RF7URS0HG+\J 2017;111:22-29.
4. Delamou et al. %0-*OREDO+HDOWK 2017;2:e000202.
5. Delamou et al. $IU-5HSURG+HDOWK 2017;21(1):104-113.

Associated Facility

Central ResearchLaboratory

The aim of Central Research Laboratory is

instruments to perform basic, translational, andto operate and e f ficiently manage common

clinical research on the imaging features ofequipments and to support general laboratory

infectious diseases. We operate Nikon Infectious

activities in the institute. In addition, thisDisease Imaging Core laboratory established inlaborator y also suppor ts research activities

April 2015. The laboratory has equipped Laser

conducte d in the institute by ex tramural

Scanning Confocal/Fluorescence Microscope

investigators.

(NIKON), Imaging Flow Cy tometer (Luminex),○Molecular & Cellular Biology Unit

Microscope (ZEISS), and a Virtual Slide Scanner

L a s e r S c a n n i n g C o n fo c a l/S u p e r re s o l u t i o n
Molecular & Cellular Biology Unit is(Nanozoomer 2.0-RS, Hamamatsu Photonics).

responsible to maintain and operate following
equipment located in Central Research○Electron Microscope Unit

Laboratory; 16- and 48-capillary sequencers,

Electron Microscope Unit suppor ts

GS junior genome sequencer and Massultrastructural characterization of microbial

Spectrometr y-based Genotyping system forpathogens and the structural chang e of theg e n o m e a n a l y s i s; F l ow C y t o m e t e r fo r c e l lpathogen-infected cells. This unit offers highfunction analysis; Fluorescence-luminescenceq u a l i t y i m a g i n g s e r v i c e s b y s t a t e - o f- a r t

imager for visualization analysis; and Luminex

techniques such as conventional and

Bead-array system and Fluorescence-

immuno - electron microscopy and 3D

luminescence Multilabel Counter for

to mography, and also prov ides t raining on

Shinjiro Hamano

multipurpose analysis. In addition, this unit issample preparation and equipment usage. This

Mihoko Kikuchi

also responsible for maintaining theu n i t i s r e s p o n s i b l e f o r Tr a n s m i s s i o n a n dequipment/facilities to suppor t generalS c a n n i n g E l e c t ro n M i c r o s c o p e s (J EO L ),laboratory activities; such as Pure Water Supply,U l t r a - M i c r o t o m e s ( L E I CA a n d R E I C H E R T ),Ultracentrifuge, Lyophilizer, Speed-Vac, Frenchvacuum coater, Hydrophilic Treatment Device,

p re s s , B i o r u p t o r, s a m p l e s t o r a g e i n l i q u i d

a n d O s m i u m P l a s m a C o a t e r i n a d d i t i o n to

Head and Professor

Senior Assistant Professor
Assistant Professor

Miako Sakaguchi

nitrogen, Autoclave, dark room and cold room.

general laboratory facilities for a wide range
application of electron microscopy.

○Light Microscope Unit
L ight Microscope Unit provides optical

17

NEKKEN Bio-Resource Center (NBRC)

Associated Facility

NEKKEN Bio-Resource
CenterProject Representative, Professor

Osamu Kaneko

Service Manager, Assistant Professor

Makoto Kazama

including NBRC, (2) supply of a variety of

was established in 2015 to take charge of

protozoan

strains,

National

depositsofBioResource

Project(NBRP)

mission in Institute of Tropical Medicine(3)

acceptanceofstrains,(4)

protozoan

preservation and maintenance of protozoan(NEKKEN). NBRP constructs the frameworkstrains, (5) supply of protozoan specimens

for systematic collection, preservation, andfor practice of education in academic

distribution of bio-resources with a focus onorganizations such as medical school. To

those that required strategic development

facilitate the collection, preservation, andby the National Government. To promote life

provisionsciences it is important for researchers to

implements the development of relatedshare the various bio-resources necessary

technologies. Approximately 800 strains offor pursuing researches and developments.

pathogenic

NEKKEN has participated to NBRP services

NBRC, and approximately half of them aresince 2002 when it was initiated by theavailable to supply. NBRC has provided 856

Ministry

Sports,protozoan strains until last year. Your

Science and Technology (MEXT), and has

cooperation and support to the project

been maintained by Japan Agency forwould be highly appreciated. Pathogenic

Medical Research and Development (AMED)

protozoan resources available from NBRC

from 2015. We have been serving as Division

are listed in the following website.

ofof

Education,

Protozoa

in

Culture,“Pathogenicof

bio-resources,

protozoa

are

NBRC

also

preservedinEukaryotic

Microorganisms of a Core Facility Upgrading

http://www.tm.nagasaki-u.ac.jp/nbrc/

Program” under Medical Mycology ResearchE-mail: protozoa@tm.nagasaki-u.ac.jp

Center (MMRC), Chiba University.
NBRC
education

supportsoftheresearchandpathogenic

protozoa

byproviding following services; (1) web-based
database of information about owners andstrains of pathogenic protozoa in Japan

Associated Facility

Neglected Tropical Diseases
Innovation Center(NTDi Center)

The Neglected Tropical Diseases (NTDs) are a

Japan has been leading the G7 by supporting thegroup of infectious diseases that prevail in thecore programs such as the Pacific Programme totropical and poverty-stricken areas. They affectEliminate Lymphatic Filariasis (PacELF). As amore than one billion people worldwide, resulting

national collaborative center for tropical medicine,in prolonged poverty and economic hardship at

NEKKEN has a mission to take the leadership roleboth individual and geographical unit levels.

in research and development (R&D) to effectively

Ryutaro Hashimoto, then Japanese Primeeliminate or eradicate NTDs. To strengthen our

Minister, kicked off the global parasite strategy to

mission, NEKKEN has established an in-housecombat

NTDs

Initiative.

The

in

1998,

Initiative

so-called

Hashimotosection “Neglected Tropical Diseases Innovation

createdtheglobalCenter (NTDi Center)” in 2016, mandating tomomentum including various milestones; such as

promote a project to utilize institutional excellence

the NTD Roadmap in 2012, the International

for developing innovative product and to search

Public-Private

forPartnership,

and

the

LondonDeclaration for the mission to eradicate, eliminate

Kenji Hirayama

funding

organizedbyand control 10 NTDs by 2020. Also, in May 2013,

To accelerate this activity, Center is supporting a

the World Health Assembly resolved the resolution

hospital based cohort in Kenya to establish a drug

WHA 66.12, expanding the NTD definition to 17

vaccine trial site by PPP mechanism.

illnesses, which worked as another driver for

Director, Professor

appropriate

industry-academia-government partnership (PPP).

Center also initiated supporting activity toactive, global deployment of the initiative. 20

makediseases are currently classified under NTDs, as oforganizations,

October 2018.

Japan through maintaining an office of Japan

Since the Hashimoto Initiative rolled out,anetwork

betweeninstitutions

and

NTDs

relatedresearchersin

Alliance on Global NTDs (JAGntd) since 2018.

Professor

Satoshi Kaneko
Professor

Tsuyoshi Kihara

18

Associated FacilityOﬃce of Coordinationfor Humanitarian Aﬀairs

Section Chief, Professor

Taro Yamamoto(Introduction)
In 2016, the Office of Coordination for
Humanitarian Affairs was set up in our
institute. Prof. Taro Yamamoto, who also
heads the Department of International
Health and Medical Anthropology, wasnominated as the first chief of this section.
One year has passed since its inception
during which time we have dispatchedmissions to natural disaster affected areas
and yellow fever epidemic areas.
（Aims）
The aims of this office are to provide
support to both natural and manmade
disaster areas. In order to undertake thesemissions, this office shall develop morehuman resources, do research, and become
the center of an international humanitarian
network.

Tohoku region in 2011 just after the East
Japan Great Earthquake, West Africa in 2014
and Nepal 2015.
These activities make
NEKKEN one of the leading organizations inJapan in terms of disaster relief activities.
Further, the infectious diseases team forJapanese Disaster Relief was decided in acabinet meeting in October, 2015 based
upon the fact that Ebola broke out in West
Africa in 2014 and there was an internationalcall for cooperation to help deal with it.
NEKKEN is expected to serve as one of themain stakeholders in this field and was asked
to participate on that team.
Because of all these events, setting up
the Office of Coordination for Humanitarian
Affairs was proposed.

（Organization）
１.Office of Coordination for Humanitarian
Affairs was set up in NEKKEN
２.Appoint one section chief (professor)（Past, Present and Future）
NEKKEN has dispatched missions to
disaster afflicted areas such as Haiti in 2010,

This is a short-course of tropical medicine. This

Three-month Course on
Tropical Medicine

course is run by the steering commit tee, whichcourse aims to suppor t medical and co - medical

consists of members from both inside and outside

personnel who plan to work in the tropics, by providing

the Institute of Tropical Medicine (NEKKEN).

oppor tunities to learn a broad range of skills andDuring thirteen weeks (April to June), the full-timeknowledge relevant to practicing medicine,staff members of NEKKEN and a substantial

implementing disease control programs and conducting

number of visiting professors and lecturers provide

medical research in tropical and developing countries.

lectures, laboratory practical and field work, in the

The course began in 1978 and since 2017, it opens tof i e l d s of v iro l o g y, b a c t e r i o l o g y, p rotozoolog y,

the researchers who pursue technology for global

parasitolo g y, m e d i c a l e n t o m o l o g y, p a t h o l o g y,health. Over 15 participants are accepted to attend theimmunogenetics, epidemiology, human ecology,

course in each year. As of the 42th course in 2019, 567

social medicine, clinical medicine and also

participants in total (including 206 medical doctors, andgeography and culture in tropics. Participants who

3 61 c o - m e d i c a l s u c h a s v e t e r i n a r i a n , n u r s e s ,successfully completed the course are awarded thecommunity health nurses, midwives, pharmacists)

Diploma in Tropical Medicine.

from all over Japan have completed the course. The

Admission ceremony in 201919

Publications
Our official publications are as follows;

長崎大学熱帯医学研究所

年報

1．Bulletin of Nagasaki University Institute of Tropical Medicine

平成29年度（2017）(In Japanese, published yearly since 1964; PDF files areavailable at our web page.)

長崎大学熱帯医学研究所

国立大学法人 長崎大学

1

熱帯医学研究所

2．Japanese Brochure (In Japanese, published yearly since
1977; PDF files are available at our web page.)

2

Nagasaki University

Institute ofTropical Medicine

2018

3．English Brochure: INSTITUTE OF TROPICAL MEDICINENAGASAKI UNIVERSITY (This copy, published yearly since
1977; PDF files are available at our web page.)

3

4．Report of Nation-wide Cooperative Research Projects(Information on research activities and achievements as anation-wide

cooperative

research

centerfor

tropicalmedicine is compiled.)

420

for Hotarujaya
Main bus routefor Mogi

SohukujiSuwa Shrine
Civic Center
Suwa-jinja
Shrine-o- bashi
Civic Hall
Chu

Electric Tramway
JR Kyushu

Institute of Tropical
Medicine
University Hospital
School of
Dentistry

School ofMedicine
UrakamiCathedralfor Akasako

Igakubu-mae

Peace Park
Ohashi
Peace Park

Hamaguchimachi
AtomicBomb
MuseumSofukujiTempleShinchi
Chinatown
Ohato

Nagasaki Station

UrakamiStationIshibashi

NagasakiUrakamiHow to get the Institute○From JR Nagasaki Station▶Electric Tramway Nagasaki Station (bound for Akasako ) → Atomic Bomb Museum → about 10-minute walk
▶Nagasaki Bus Nagasaki Station (No.8 bound for Shimoohashi via School of Medicine ) → School of Medicine○From JR Urakami Station▶Electric Tramway Urakami Station (bound for Akasako ) → Atomic Bomb Museum → about 10-minute walk
○From Nagasaki Airport▶Kenei Bus Nagasaki Airport No.4 Bus Stop (For Nagasaki Sta . (via Showa-machi / via Showa-machi・Sumiyoshi ))→ Hamaguchi-machi → about 10-minute walkNagasaki University

Institute of Tropical Medicine
LocationURL

1-12-4 Sakamoto Nagasaki 852-8523
http://www.tm.nagasaki-u.ac.jp/nekken/