Safety Summary Sheet
Terephthalic acid （CAS NO. 100-21-0）
SPECIES

Terephthalic acid

PROTOCOL

RESULTS（CAS NO.: 100-21-0）
PHYSICAL-CHEMICAL
2.1

Melting Point

Unknown>300, 402, 425℃

2.2

Boiling Point

Unknown

Sublime

2.3

Density

DIN 5314

Bulk density : 1.12 g/cm3

Not specified

Density : 1.5 g/cm3

Not specified

Density : 1.51 g/cm3

2.4

Vapour Pressure

Not specified

3×10-10 hPa (20 ℃) (extrapolated
from vapor pressures measured attemperatures between 250 and427 ℃)

2.5

Partition Coefficient(log Kow)

Not specified

LogKow : 2

2.6.1A

Water Solubility

Not specified

15 mg/l (10 ℃) (not soluble)

Not specified

19 mg/l (25 ℃) (not soluble)

Not specified

pKa1 : 3.52, pKa2 : 4.46 (25 ℃)

Calculation by
AopWin v1.90

half life : 8.647 days

2.6.1.B

Dissociation Constant（pKa）

ENVIRONMENTAL FATE AND PATHWAY
3.1.1

Photodegradation

reaction rate constant with hydroxyl
radicals: 1.2370x10-12 cm3/mol-sec

3.1.2

Stability in Water

No data

3.1.3

Stability in Soil

No data

3.2

Monitoring Data

Surface water,bottom sediment

Surface water : 0.060-0.12μg/l(detected from 2 out of 23 areas inJapan, 2002)
Bottom sediment : 10-20 ng/g dryweight (detected from 4 out of 21
areas in Japan, 2002)

3.3.1

3.3.2

Transport between
Environmental Compartments

Distribution(Koc etc.）

1

Atomosphericconcentration ; air

11.1 ng/m3 (average of 6 days; max.
23 ng/m3) (Japan, 1990 [reported])

Sewage plantdrainage; surfacewater

13 ng/l (Washington D.C., US, 1975)

Calculation
byFugacity Level Ⅲ
model (EPIWIN v.
3.05, MW 166.13,LogKow
2.00,
vapour pressure
1.19x10-5mmHg
25 ℃ , watersolubility 15mg/l
20℃)

Air : 0.000012%
Water : 32.7%

Calculation
PCKOCWINv.1.66

LogKoc : 1.855by

5.3μg/l (Japan, 1975)

Soil : 67.2%
Sediment : 0.098%

Terephthalic acid

SPECIESPROTOCOL

RESULTS（CAS NO.: 100-21-0）
3.4

Biodegradation

3.5

BOD-5, COD or BOD-5／
COD ratio

3.6

Bioaccumulation

OECD TG 301 C(ReadyBiodegradability:
ModifiedMITI
Test (I))

74.7% (O2 consumption, 14 d)

OECD TG 301 B(ReadyBiodegradability:
Modified SturmTest) etc.

Readily biodegradable(supported by a lot of test reports)

99.3% (UV-VIS, 14 d)
100% (HPLC, 14 d)

No dataCalculation byBCF: 2EPIWIN(unspecifiedversion)

ECOTOXICOLOGY
4.1

4.2

4.3

Acute Toxicity to Fish

Acute Toxicity to Aquatic
Invertebrates (Daphnia etc.)

Toxicity to Aquatic Plants(Algae etc.)

Oryzias latipes

OECD TG 203(Fish, Acute Toxicity Test)

LC50 (96h) : >19 mg/l

Leuciscus idus
melanotus

OECD TG 203(Fish, Acute Toxicity Test, static)

LC50 (96h) : >1000 mg/l*

Salmo gairdneriOECD TG 203(Fish, Acute Toxicity Test, semistatic)

LC50 (96h) : 798-1640 mg/l (meanvalue 1157 mg/l)*

Brachydanio
rerioOECD TG 203(Fish, Acute Toxicity Test, static)

LC0 (96h) : >500 mg/l*

Daphnia magna

OECD TG 202(Daphnia sp.
AcuteImmobilisation
Test)

EC50 (48h) : >20 mg/l*

Daphnia magna

OECD TG 202(Daphnia sp.
AcuteImmobilisation
Test, static)

EC50 (48h) : >1000 mg/l*

NOEC (96h) : >=1000 mg/l*

NOEC (48h) : 600 mg/l*

Selenastrum
capricornutum(new name:
Pseudokirchnerella subcapitata)

OECD TG 201(Alga, GrowthInhibition Test)

Growth rate :EC50 (72h) : >18 mg/l
NOEC (72h) : 18 mg/l
Biomass:
EC50 (72h) : >19 mg/l
NOEC (72h) : 19 mg/l

Selenastrum
capricornutum(new name:
Pseudokirchnerella subcapitata)

OECD TG 201(Alga, Growth
Inhibition Test,static)

Biomass:
EC50 (96h) : >1000 mg/l *NOEC (96h) : >1000 mg/l*

2

Terephthalic acid

SPECIESPROTOCOL

RESULTS

Activated sludge(predominantlydomesticsewage)

OECD TG 209(Activatedsludge, Respiration Inhibition
Test, static)

EC50 (16d) : 1392.8 mg/l*

Fasciola hepatica (protozoa)

Unknown

EC0 (2h) : 830 mg/l*

Tetrahymena
pyriformis(protozoa)

Unknown(motilityinhibition)

EC50 (24h) : 800 mg/l*

Caenorhabditis
elegans(nematode)

Unknown

EC0 (unknown period) : 1 μg/l

（CAS NO.: 100-21-0）
4.4

Toxicity to Microorganisms(Activated Sludge Respiration
Inhibition test etc.)

4.5.1

Chronic Toxicity to Fish

4.5.2

Chronic Toxicity to Aquatic
Invertebrates

Daphnia magna

OECD TG 211(Daphnia magna
Reproduction
Test)

EC50 (21d) : >20 mg/l
NOEC (21d) : 20 mg/l

4.6

Toxicity to Terrestrial
Organisms

Avena sativa

Unknown

EC0 (seedling root elongation; 1d) :100 mg/l*

Oryza sativa

Unknown

EC0 (seedling root elongation; 5d) :>10 mg/l
EC20 (seedling root elongation; 5d) :100 mg/l*

Drosophilamelanogaster

Unknown

LC0 (mortality, 3d): 166 mg/kg bw

4.6.1

No data

Toxicity to Sediment Dwelling
Organisms

No data

TOXICOLOGY
5.1

5.2

Toxicokinetics, Metabolism
and Distribution

Rat

Unknownabsorbed rapidly, distributed mainly tokidney and excreted to urine asterephthalic acid,Rat

Unknown(Feto-placentalTransfer)

Transported to the fetus, however
the concs. in fetus tissues were
low relative to the corresponding
maternal ones.

Acute Toxicity

A.

Acute Oral Toxicity

Rat

Unknown

LD50 : ＞5000 mg/kg

B.

Acute Inhalation Toxicity

Rat

Unknown

LC50 : ＞2.02 mg/L (2hr)C.

Acute Dermal Toxicity

RabbitUnknown

LD50 : ＞2000 mg/kg

D.

Acute Toxicity, Other Routes

5.3

No data

Irritation/Corrosion

A.

Skin Irritation/Corrosion

No dataB.

Eye Irritation/Corrosion

No data

Skin Sensitization

No data

5.43

Terephthalic acid

SPECIESPROTOCOL

RESULTS（CAS NO.: 100-21-0）
5.5

Repeated Dose Toxicity

5.6

Rat

Unknown(oral feed, 15 wks)

NOAEL :
male ; 1220 mg/kg/day
female ; 1456 mg/kg/day

Rat

Unknown(oral feed, 2 yrs)

NOAEL :
male ; 142 mg/kg/day
female ; <20 mg/kg/day

Rat

Unknown(inhalation,14 wks)

NOAEL : 1.2 mg/m3

Genetic Toxicity in vitro

A.

Gene Mutation(Bacterial Test etc.)

S. typhimurium
and E. coli

B.

Chromosomal Aberration

5.7

Method byJapaneseIndustrial Safety
and Health Act

Negative

CHL/IU

Unknown

Negative

Genetic Toxicity in vivo

MouseOECD TG 474(Micronucleusassay, ip)

Negative

5.8

Carcinogenicity

Rat

Unknown(oral feed, 2 yrs)

male ; no tumors
female ; bladder tumors at
1000mg/kg/day, which is believed tobe caused by bladder calculi andunlikely for human (OECD SIAR)

5.9

Toxicity to Reproduction

A.

Toxicity to Fertility

Rat

Unknown(oral feed,one-generationstudy)

NOAEL :
Reproductive. ; 2480~3018mg/kg/day
Parental & pups ; 240～307mg/kg/day

B.

Developmental
Toxicity/Teratogenicity

Rat

Unknown(inhalation)

NOAEL :
Maternal & developmental ;10.0 mg/LNot teratogenic

5.10

Other relevant information

No data

5.11

Experience with HumanExposure

No data* : greater than the solubility in waterContact : http://www.sumitomo-chem.co.jp/english/contact/

IMPORTANT: While the data and information compiled herein are presented in good faith andbelieved to be accurate or valuable, it is provided for your reference only. It is expressly or
implicitly understood that Sumitomo Chemical makes no warranty or assumes no liability or
obligation for the data and information provided.

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