GPS/JIPS Safety Summary Reference No.：1001

GPS/JIPS Safety Summary
1. SUBSTANCE NAME
Glycine (CAS No.56-40-6)
2. GENERAL STATEMENT
Glycine of YUKI GOSEI KOGYO CO., LTD. is used as food additives, pharmaceuticals,
cosmetics, industrial materials and reagents.
Glycine is a protein-constituting amino acid and human usually take lots of protein
including glycine as a nutrient from foods. No particular problems regarding safety havebeen found so far in the use of glycine in various fields e.g. veterinary drugs, feedadditives.
Worker exposure to glycine via dermal and inhalation routes is expected in industrial
uses during manufacturing or processing of glycine and products containing glycine.
Therefore, it is recommended to use a closed system, machine or local exhaust
ventilation system to ensure adequate ventilation as well as providing appropriate
personal protective equipments (e.g. safety goggles, respiratory protection such asmasks, gloves) in order to minimize exposure.
When consumers use products containing glycine, be sure to use the products inaccordance with the instruction manuals attached. In addition, emissisons to theenvironment is expected during industrial uses such as manufacturing or processing ofglycine, or uses of products containing glycine. Therefore, it is recommended to takemeasures to prevent leakage and to install waste water treatment equipment and carryout periodic maintenance of equipment in order to minimize the impact on environmentalorganisms.
3. CHEMICAL IDENTITY
General nameBrand name
IUPAC name
CAS number
Other identical numbers
Molecular formula
Structural formula

GlycineGlycineAminoacetic acid56-40-6
EC number: 200-272-2
MITI Number: (9)-77 (CSCL1), ISHA2))
H2NCH2COOH

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Other information
References

Not specified
NikkajiWeb
NITE Chemical Risk Information Platform (NITE-CHRIP)

1) Chemical Substances Control Law in Japan
2) Industrial Safety and Health Act in Japan

4. USES AND APPLICATIONS
Main uses

Glycine of YUKI GOSEI KOGYO CO., LTD. is used as foodadditives, pharmaceuticals, cosmetics, industrial materials
and reagents.

5. PHYSICAL/CHEMICAL PROPERTIES
Property
Form (physical state)
ColourOdour
Relative density
Melting point / Boiling point
Flammability

Flash point
Explosive properties
Autoflammability / self-ignition
temperature
Vapour pressure
Molecular Weight
Water solubility
Partition coefficient n-octanol / water
Reference

Value

Crystalline powder (20°C, 1013 hPa)WhiteOdourless
1.161 g/cm3 (20°C)
Melting point: 233°C (dec)
Non flammable
No pyrophoricity
No flammability on contact with water
Not applicableNot explosive
Not self-heating
0.0000171 Pa (25°C)
75.05
250 g/L (25°C)
log Kow = -3.21
Chemical Safety Report, Safety Data Sheet

6. HEALTH EFFECTS
Effect Assessment
Acute toxicity
Skin corrosion / irritation
Serious damage / eye irritation
Respiration sensitization
Skin sensitization
Genetic toxicity

ResultNo adverse effect observed
No adverse effect observed (not irritating)No adverse effect observed (not irritating)
No study available
No adverse effect observed (not sensitizing)No adverse effect observed (negative)
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Carcinogenicity
Reproductive toxicity
Repeated dose toxicity
Reference

No adverse effect observed
No adverse effect observed
No adverse effect observed
Chemical Safety Report

7. ENVIRONMENTAL EFFECTS
Effect Assessment
Aquatic Toxicity
No hazard identified
Hazardous to the ozone No hazard identified
layer
Reference
Chemical Safety Report

ResultFate and behaviour
Mobility in environment

Result

Biodegradation
Bioaccumulation
potential
PBT/vPvB conclusion
Reference・Potential for adsorption to organic soil is low on the basis of
the estimated Koc of 1 at 25°C.
・Evaporation from the water surface into the atmosphere is
not to be expected on the basis of the estimated Henry’s
Law constant H of 0.000000001 Pa・m3/mol at 25°C.
A screening test according to OECD test guideline resulted
in readily biodegradable.
Model calculations confirm a low bioaccumulation potentialfor glycine.
Not a PBT / vPvB substanceChemical Safety Report

8. EXPOSURE
Subject
Workerexposure

Consumer
exposure

Exposure potential for main uses of our products(Route of exposure)
Worker exposure to glycine via dermal and inhalation routes is
expected in industrial uses during manufacturing or processing ofglycine and products containing glycine. (PROC3, PROC4)
PROC3: Manufacture or formulation in the chemical industry inclosed batch processes with occasional controlled exposure orprocesses with equivalent containment condition
PROC4: Chemical production where opportunity for exposure arises
Consumer exposure via oral route is expected as glycine is used asfood additives, feed additives and pharmaceuticals.
Consumer exposure via dermal and inhalation routes is expected
when using products containing glycine (e.g. cosmetics, personal careproducts).

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Environmental
exposure

Emission to the environment is expected during industrial uses suchas manufacturing or processing of glycine, or uses of products
containing glycine.

9. RISK MANAGEMENT RECOMMENDATIONSSubject
WorkerexposureConsumer
exposure
Environmental
exposure

Remarks
Notes

Recommended Risk Management Measures- Use a closed system, machine or local exhaust ventilation system toensure adequate ventilation in order to minimize exposure.
- Take measures to prevent dust generation. In the case of dustgeneration, consider to use dust protection mask or powered air
purifying respirator as well as simple dust mask.
- Use appropriate personal protective equipments (e.g. safety
goggles, respiratory protection such as masks, gloves) and be sureto have an eyewash and shower equipment near the handling area.
- Workplace managers ensure to train and educate workers on theselection and use of appropriate protective equipments and the wayof maitaining workplace safety.
- Use in accordance with instruction manuals attached to the products- Take measures to prevent leakage and to install waste water
treatment equipment and carry out periodic maintenance ofequipment in order to minimize the impact on environmentalorganisms.
- Prevent residues of glycine or products containing glycine fromentering rivers, surface water channel or drains.
None
None

10. SUBSTANCE REVIEW INFORMATION
Review Program
International Chemical
Safety Cards (ICSC)OECD High Production
Volume Chemicals (HPVChemicals)
Evaluations of the Joint
FAO/WHO Expert
Committee on Food
Additives (JECFA)

Review status－－

Evaluation of certain food additives: sixty-third report of theJoint FAO/WHO Expert Committee on Food Additives.
http://apps.who.int/iris/bitstream/handle/10665/43141/WH
O_TRS_928.pdf;jsessionid=8F2B96D00DFCB2430CA359
2C4BF0EA64?sequence=14/6

GPS/JIPS Safety Summary Reference No.：1001Others
Japan HPV Challenge
ProgramFinal Report is available from:http://www.safe.nite.go.jp/jcheck/detail.action?cno=56-40-6&mno=9-0077&request_locale=ja

11 Regulatory information / GHS classification and labelling information
Regulatory information
Legislation
REACH

Chemical Substances Control
Law (CSCL) in Japan
Industrial Safety and Health
Act (ISHA) in Japan
Food Sanitation Act in JapanAct on Safety Assurance andQuality Improvement of Feeds
in Japan
The Law on Securing Quality,Efficacy and Safety ofProducts Including
Pharmaceuticals and Medicaldevices in Japan

Regulatory status
Registered Substance
http://echa.europa.eu/registration-dossier/-/registereddossier/14889
Existing Chemical
Existing Chemical
Designated additives, Article 10 of the act, appended
table 1 cited in Article 12 of Ordinance for Enforcement
Feed additives, Article 2 (3) of the Act, Notice ofMinistry of Agriculture and Forestry and Fisheries ofJapan No. 270 (4th February, 2010)
Pharmaceuticals, Listed in Japanese Standards ofQuasi-drug Ingredients

GHS classification
Type of hazard
Physical hazard
Health hazard
Environmental hazard

Not classified
Not classified
Not classified

GHS labelling elements
Pictogram / symbol
Signal word
Hazard statement

Not applicableNot applicableNot applicable

Classification

12. CONTACT INFORMATION
Company name:
Address:

YUKI GOSEI KOGYO CO., LTD.
10-4, Nihongashi-Ningyocho 3-Chome, Chuo-ku 103-0013

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Tokyo, Japan
Department in charge:
Sales Division
Telephone / FAX numbers: +81-3-3664-3982 / +81-3-3664-3991
13. DATE OF ISSUE / REVISION DATE / OTHER INFORMATION
Date of issue: December 3, 2018
Revision history:
Revision date

Sectionchanges

Version

Other information: None
14. DISCLAIMER
This GPS safety summary is intended to provide information on chemical products as abrief summary in line with GPS (Global Product Strategy) of the chemical industry. It does
not provide expert information such as risk assessment procedures and/or effects onhuman health and the environment. It is not intended to replace Safety Data Sheet (SDS)
or Chemical Safety Report (CSR). The information provided is based on the regulations,materials and information available at the date of its publication, however, it provides nowarranty or representation regarding the content. In addition, it is not intended to specify
the quality of the product.

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