News Release
Notice Regarding Issuance of JPY Hybrid Bonds
OSAKA, Japan, April 15, 2024 – Takeda Pharmaceutical Company Limited (Head Office: Chuo-ku, Osaka;(TSE:4502/NYSE:TAK), “Takeda”) today announced that it will issue its 2nd Unsecured, Interest
Deferrable and Early Redeemable Subordinated Bonds (“the 2nd Hybrid Bonds”) in the form of a public
offering in Japan to refinance the whole or part of the 1st Unsecured, Interest Deferrable and Early
Redeemable Subordinated Bonds (“the 1st Hybrid Bonds”) that were issued on June 6, 2019. In preparation
for the upcoming issue in 2024, Takeda today filed an Amended Shelf Registration Statement for theissuance of the 2nd Hybrid Bonds with the Director of the Kanto Local Finance Bureau.
1. Purpose and Background of the 2nd Hybrid Bonds Issuance:
Takeda issued the 1st Hybrid Bonds of JPY 500 billion in June 2019 after the acquisition of Shire plc. As aresult, hybrid bonds have formed an important part of Takeda’s capital structure, and this importance remains
unchanged. With the 1st Hybrid Bonds approaching their First Call Date on October 6, 2024, Takeda plans toreplace the 1st Hybrid Bonds with the proceeds from the issuance of the 2nd Hybrid Bonds and (if needed)
Hybrid Loans having similar terms.
2. Features of the 2nd Hybrid Bonds:
The 2nd Hybrid Bonds will contain features of debt and equity. As a debt instrument they will carry aninterest coupon and have a final maturity date. As an equity instrument they will be subordinated to SeniorNotes and other debt instruments, allow interest coupon deferral, and have a very long maturity of up to 60Years. Given such hybrid debt / equity features, we expect that the 2nd Hybrid Bonds will receive an equity
acknowledgement of 50% from Rating Agencies. We note that despite the equity like features, the 2nd Hybrid
Bonds are not convertible to equity and will never cause a dilution of equity holders.
3. Schedule:
The 2nd Hybrid Bonds are expected to be priced and issued in mid-2024 subject to market conditions andinvestor demand. Details will be announced as soon as the terms are determined.
Disclaimer
This announcement has been prepared to publicly disclose the proposed offering of the 2nd Hybrid Bonds andis not intended to, and does not, constitute, represent or form part of any offer, invitation or solicitation of an
offer to purchase, otherwise acquire, subscribe for, sell or otherwise dispose of, any securities whether
pursuant to this announcement or otherwise.
This document does not constitute an offer to sell or a solicitation of an offer to purchase any securities1within the United States. The 2nd Hybrid Bonds have not been and will not be registered under the U.S.
Securities Act of 1933 (the “Act”) and may not be offered or sold in the United States, absent registration oran applicable exemption from the registration requirements. No 2nd Hybrid Bonds will be offered in theUnited States.
About Takeda
Takeda is focused on creating better health for people and a brighter future for the world. We aim to discoverand deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal
and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together
with our partners, we aim to improve the patient experience and advance a new frontier of treatment options
through our dynamic and diverse pipeline. As a leading values-based, R&D-driven biopharmaceuticalcompany headquartered in Japan, we are guided by our commitment to patients, our people and the planet.
Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in thevalues that have defined us for more than two centuries. For more information, visit www.takeda.com.
Contacts
Investor Relations
Christopher O’Reilly
christopher.oreilly@takeda.com+81 (0) 3-3278-2543

Media Relations
Brendan Jenningsbrendan.jennings@takeda.com+81 (0) 80-2705-8259

Important Notice
For the purposes of this notice, “press release” means this document, any oral presentation, any question andanswer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company
Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any questionand-answer in connection with it) is not intended to, and does not constitute, represent or form part of any
offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell orotherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No sharesor other securities are being offered to the public by means of this press release. No offering of securities
shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, asamended, or an exemption therefrom. This press release is being given (together with any further information
which may be provided to the recipient) on the condition that it is for use by the recipient for information
purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction).
Any failure to comply with these restrictions may constitute a violation of applicable securities laws.
The companies in which Takeda directly and indirectly owns investments are separate entities. In this press
release, “Takeda” is sometimes used for convenience where references are made to Takeda and its
subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries ingeneral or to those who work for them. These expressions are also used where no useful purpose is served byidentifying the particular company or companies.

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Forward-Looking Statements
This press release and any materials distributed in connection with this press release may contain forwardlooking statements, beliefs or opinions regarding Takeda’s future business, future position and results ofoperations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking
statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”,“aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”,“projects” or similar expressions or the negative thereof. These forward-looking statements are based onassumptions about many important factors, including the following, which could cause actual results to differ
materially from those expressed or implied by the forward-looking statements: the economic circumstances
surrounding Takeda’s global business, including general economic conditions in Japan and the United States;
competitive pressures and developments; changes to applicable laws and regulations, including global healthcare reforms; challenges inherent in new product development, including uncertainty of clinical success anddecisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new andexisting products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates;
claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact ofhealth crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including
foreign governments in countries in which Takeda operates, or on other facets of its business; the timing andimpact of post-merger integration efforts with acquired companies; the ability to divest assets that are notcore to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s
most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities andExchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/sec-filings-andsecurity-reports/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking
statements contained in this press release or any other forward-looking statements it may make, except as
required by law or stock exchange rule. Past performance is not an indicator of future results and the results
or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast,guarantee or projection of Takeda’s future results.
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