୙㐺ษ䛺බ⾲ᩥ⊩ሗ࿌᭩

23Ᏻ඲ᛶ䛻㛵䛩䜛ᑂᰝ䛷
䛿㎰⸆౑⏝⪅䛻ᑐ䛩䜛ᙳ㡪䜔ື᳜≀䛻ᑐ䛩䜛ᙳ㡪䜒௨๓䜘䜚䛿඘ᐇ15ᖺ䛻୍ᗘ䚸෌ホ౯ไᗘ䛜ᑟධ䇿᭱᪂䛾⛉Ꮫⓗ᰿ᣐ䛻↷䜙䛧䛶Ᏻ඲ᛶ➼䛾෌ホ౯䜢⾜䛖䇾䛸᫂グ4Ꮫ⾡ㄽᩥ䛿෌Ⓩ㘓䛻⪃៖䛥䜜䛶䛣䛺䛛䛳䛯䛜䚸㎰⸆෌ホ౯䛷䛿䚸᭱᪂䛾⛉Ꮫ᝟ሗ䛸䛧䛶බ⾲ᩥ⊩䜒ྲྀ䜚ධ䜜䜛䛣䛸䛻䛺䛳䛯䚹䠄཰㞟䛿㎰⸆௻ᴗ䠅䛣䜜䜎䛷㎰⸆䛿3ᖺ
ẖ䛻෌Ⓩ㘓䜢⾜䛳
䛶䛝䛯䛜䚸᳨ᰝ䛿ཎ๎┬␎䛷ᙧᘧⓗ䚹

2018ᖺ6᭶㎰Ỉ┬㈨ᩱ䜘䜚㎰⸆෌ホ౯ไᗘ㐃⤡ඛ䠖jkkuro582*gmail.com (*䜢@䛻⨨䛝᥮䛘䛶䛟䛰䛥䛔䠅⎔ቃ⬻⚄⤒⛉Ꮫ᝟ሗ䝉䞁䝍䞊 ๪௦⾲ ་Ꮫ༤ኈNPO䝎䜲䜸䜻䝅䞁䞉⎔ቃ䝩䝹䝰䞁ᑐ⟇ᅜẸ఍㆟ ⌮஦᪥ᮏෆศἪ᧠஘≀㉁Ꮫ఍ ⌮஦䝕䝖䝑䜽䝇䞉䝥䝻䝆䜵䜽䝖䞉䝆䝱䝟䞁 㢳ၥᏊ䛹䜒䜿䝭䝛䝑䝖 ୡヰே䚸䜸䝤䝄䞊䝞䞊2018ᖺ6᭶㎰Ỉ┬㈨ᩱ䜘䜚␲ၥ䜔㉁ၥ䚸䛤ពぢ䛜䛒䜚䜎䛧䛯䜙䚸᫝㠀䛚▱䜙䛫䛟䛰䛥䛔䚹ᮌᮧ―㯮⏣⣧Ꮚ㎰⸆ྲྀ⥾ἲᨵṇ␲ၥ䜔㉁ၥ䛺䛹䛜䛒䜚䜎䛧䛯䜙䚸ᮌᮧ䞊㯮⏣⣧Ꮚᐄ䛻䛚▱䜙䛫䛟䛰䛥䛔䚹ෆᐜ䛻䜘䛳䛶䚸ᡤᒓᶵ㛵䛸ඹ᭷䛾ୖ䚸ཧ⪃䛻䛥䛫䛶㡬䛝䛯䛔䛸ᛮ䛔䜎䛩䚹㎰⸆෌ホ౯䛾ၥ㢟Ⅼᮏ᪥䛾ෆᐜ䛻䛴䛔䛶
ㅮ₇ෆᐜ䛿䚸ᮌᮧ䞊㯮⏣⣧Ꮚ䛾ぢゎ䛷䛒䜚䚸ᡤᒓᶵ㛵䛷୍⮴䛧䛯⥲ព䛷䛿䛺䛔䛣䛸䜢䛚᩿䜚䛧䛶䛚䛝䜎䛩䚹2023ᖺ7᭶9᪥ ᭷ᐖ໬Ꮫ≀㉁䛛䜙Ꮚ䛹䜒䜢Ᏺ䜛䝛䝑䝖䝽䞊䜽䠄Ꮚ䛹䜒䜿䝭䝛䝑䝖䠅Ꮫ⩦఍㎰⸆෌ホ౯䛾ඃඛᗘ

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⾲㘓
ᩥ⏦
⊩ㄳ
ሗ双࿌ᚲ
᭩せ叐友
厒ẘ
吸ᛶ
呎ヨ吂㦂
呎⤖
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⏝
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㎰⸆ཎయ䛿580✀䚸㎰⸆〇๣䛿⣙4000✀㎰⸆Ⓩ㘓䞉෌ホ౯䛾䝅䝇䝔䝮 㣗ရᏳ඲ጤဨ఍㈨ᩱ

7

52024ᖺᗘ30ᡂศ䚸2025ᖺᗘ42ᡂศ䜎䛷䚸ணᐃ䛜Ỵᐃ䛸බ㛤䚹
https://www.maff.go.jp/j/nouyaku/saihyoka/taisyounouyaku.html

෌ホ౯ணᐃ䛾㎰⸆→ 䜺䜲䝗䝷䜲䞁䛷䛿䚸㎰⸆䝯䞊䜹䞊䛜බ⾲ᩥ⊩䛾཰㞟䚸㑅ᢥ䚸ホ౯䜢⾜䛖䛸䛧䛶䛔䜛䚹฼┈┦཯䛾䛒䜛䝯䞊䜹䞊䛜බᖹ䛺ᩥ⊩䛾㑅ᢥ䚸ホ౯䜢⾜䛘䜛䛾䛰䜝䛖䛛䠛86• බ⾲ᩥ⊩䛾ሗ࿌᭩㎰⸆䛾ẘᛶヨ㦂䛻ྵ䜎䜜䛶䛔䛺䛔᭱᪂䛾⛉Ꮫ᝟ሗ䜢ྲྀ䜚ධ䜜䜛䛯䜑䛻㔜せ䛺᝟ሗ※䚹㎰Ỉ┬䞉㎰ᴗ㈨ᮦᑂ㆟఍㎰⸆ศ⛉఍䛜Ỵ䜑䛯䜺䜲䝗䝷䜲䞁䛻ἢ䛳䛶཰㞟䚸㑅ᢥ䚸ホ౯䛜ᐇ᪋䛥䜜䜛䚹䠄㣗ရᏳ඲ጤဨ఍䛿ே䜈䛾ẘᛶ䛻䛴䛔䛶䛾䝸䝇䜽ホ౯ᶵ㛵䛾䛯䜑䚸㝈ᐃ䛧䛯㈨ᩱ䜢౑⏝䛩䜛䜺䜲䝗䝷䜲䞁䜢ฟ䛧䛶䛧䛶䛚䜚䚸ཎ๎䛿⤒ཱྀᢞ୚䛻䜘䜛◊✲䠅→ ከ✀㢮䛾ヨ㦂䜢ᐇ᪋䛧䛶䛔䜛䛜䚸ヨ㦂᪉ἲ䛿ᪧᘧ䛷᪂䛧䛔ẘᛶヨ㦂䛿ྵ䜎䜜䛶䛔䛺䛔䚹䛥䜙䛻ヨ㦂⤖ᯝ䛿▱ⓗ㈈⏘ಖㆤ䛾䛯䜑䛸䛧䛶䛤䛟୍㒊䛧䛛බ㛤䛥䜜䛶䛔䛺䛔䚹• Ⓩ㘓䛻ᚲせ䛺ẘᛶヨ㦂䛺䛹䐟ẘᛶ䛻㛵䛩䜛ヨ㦂䠄ே䛾೺ᗣ䛻ᑐ䛩䜛ᙳ㡪䠅䠄ᛴᛶ⤒ཱྀẘᛶ䚸⓶⭵่⃭ᛶ䚸║่⃭ᛶ䚸㑇ఏẘᛶ䚸Ⓨ䛜䜣ᛶ䚸⦾Ṫẘᛶ䚸Ⓨ⏕ẘᛶ䚸Ⓨ㐩⚄⤒ẘᛶ䚸ᛴᛶ⚄⤒ẘᛶ䛺䛹䠅䐠㎰స≀➼䜈䛾ṧ␃䛻㛵䛩䜛ヨ㦂䐡⎔ቃ䜈䛾ᙳ㡪䠄ᅵተ䜈䛾ṧ␃䜔ືែ䚸㨶㢮䞉⏥Ẇ㢮䞉䝭䝒䝞䝏➼䜈䛾ᙳ㡪䛺䛹䠅㎰⸆䝯䞊䜹䞊䛜㎰⸆෌ホ౯䛾⏦ㄳ䛻ᚲせ䛺᭩㢮ẅ⹸๣ẅ⳦๣ẅ⹸๣㝖ⲡ๣ẅ⹸๣ẅ⹸๣ẅ⹸๣ẅ⹸๣㝖ⲡ๣ẅ⳦๣㝖ⲡ๣䜰䝉䝍䝭䝥䝸䝗*䜲䝋䝏䜰䝙䝹䜲䝭䝎䜽䝻䝥䝸䝗*䜾䝸䝩䝃䞊䝖4✀**䜽䝻䝏䜰䝙䝆䞁*D-D䠄1,3-䝆䜽䝻䝻䝥䝻䝨䞁)䝆䝜䝔䝣䝷䞁*䝏䜰䝯䝖䜻䝃䝮*䝏䜸䝧䞁䜹䝹䝤䝏䝣䝹䝄䝭䝗䝤䝍䜽䝻䞊䝹27.5 䝎䜴䚸᪥⏘໬Ꮫ

18135.3 ᪥⏘໬Ꮫ䚸䝞䜲䜶䝹䜽䝻䝑䝥䛺䛹90.6 䜽䝭䜰䜲໬Ꮫ

17

19

46.1 䝅䞁䝆䜵䞁䝍

167.0 ୕஭໬Ꮫ䜰䜾䝻

8353.9 䝎䜴䚸䝞䜲䜶䝹䜽䝻䝑䝥䛺䛹

74.8 ఫ཭໬Ꮫ

6164.7 ᪥⏘໬Ꮫ䚸䝅䞁䝆䜵䞁䝍䚸୕஭໬Ꮫ䜰䜾䝻䛺䛹

29

120

10

91

114

67.5 䝞䜲䜶䝹䜽䝻䝑䝥63

5.2 ᪥ᮏ᭪㐩䚸ఫ཭໬Ꮫ70.2 ఫ཭໬Ꮫ䚸䝞䜲䜶䝹䜽䝻䝑䝥䛺䛹47

䠎䠏

〇๣ 2018ᖺฟⲴ㔞 ୺䛺⏦ㄳ⪅ᩘ䠄䡐䜎䛯䛿k䠨䠅

1973

1997

1969

2000

2002

1950

2001

1980䡚

1992

2010

1995

Ⓩ㘓ᖺ

9

2021ᖺ12᭶ᮎ

2021ᖺ12᭶ᮎ

2021ᖺ12᭶ᮎ

2021ᖺ12᭶ᮎ

2022ᖺ3᭶

2022ᖺ3᭶

2022ᖺ3᭶

2022ᖺ3᭶

2021ᖺ12᭶ᮎ

2022ᖺ3᭶

2022ᖺ3᭶⏦ㄳ䛾ᥦฟᮇ㝈

4ሗ䛾ㄽᩥ䛿䚸ᾏእ䛾䝸䝇䜽ホ౯䛻౑⏝䛥䜜䛯䛯䜑䚸ሗ࿌᭩䛻㍕䛫䛦䜛䜢ᚓ䛺䛛䛳䛯䛸⪃䛘䜙䜜䜛䛜䚸୙ᙜ䛺ホ౯䛜グ㍕䛥䜜䛶䛔䜛䚹᳨⣴ᮇ㛫௨㝆䚸ᫍඛ⏕᪉䛿䛥䜙䛻㔜せ䛺ㄽᩥ䜢ከᩘⓎ⾲䛧䛶䛔䜛䛜䚸ሗ࿌᭩䛻䛿䛺䛔䚹 11ᫍಙᙪᩍᤵ䜙䛾ㄽᩥ䛿䛣䛾᳨⣴ᮇ㛫䛻11ሗ䛾ㄽᩥ䛜ฟ䛥䜜䛶䛔䜛䛜䚸7ሗ䛻䛴䛔䛶䛿䚸๐㝖䛥䜜䛯447ሗ䛻ྵ䜎䜜䛶䛚䜚䚸ሗ࿌᭩䛻᝟ሗ䛜୍ษ䛺䛔䚹᭱⤊⤖ᯝ ༊ศa䛜5ሗ䚸༊ศ䠾䛜9ሗ䚸༊ศ䠿䛜51ሗ䛣䛣䛛䜙䛂㐺ྜ䛧䛺䛔ᩥ⊩447ሗ䜢๐㝖䛧䛶692ሗ䛜ṧ䜛䛃䛸䛧䛶䛔䜛䚹
692ሗ䛻䛴䛔䛶䛿ᩥ⊩᝟ሗ䛸ホ౯ෆᐜ䛜グ㍕䛥䜜䛶䛔䜛䛜䚸๐㝖䛥䜜䛯447ሗ䛾᝟ሗ䛿୍ษ䚸グ㍕䛥䜜䛶䛔䛺䛔䚹䜽䝻䝏䜰䝙䝆䞁䛾ሗ࿌᭩䛿䚸ⱥㄽᩥ᳨⣴䝃䜲䝖Web of Science Core Collection䛷
clothianidin, Dantotsu(〇๣ྡ)䛷᳨⣴(ᮇ㛫䠖2006 ᖺ4᭶1᪥䡚2021ᖺ3᭶31᪥䠅䛩䜛䛸䚸1139ሗ䛾ᩥ⊩䛜䝠䝑䝖䚹䝛䜸䝙䝁䝏䝜䜲䝗⣔䜽䝻䝏䜰䝙䝆䞁䠄ఫఫ཭໬Ꮫᰴᘧ఍♫䠅䛾஦౛㉥Ꮠ䛿EU䛷Ⓩ㘓᢯ᾘ䚸ᮍⓏ㘓䛾㎰⸆䚹* 䝛䜸䝙䝁⣔5✀䠖䝙䝔䞁䝢䝷䝮䚸䝏䜰䜽䝻䝥䝸䝗䛿ฟⲴ㔞䛜ᑡ䛺䛔䛾䛷ᑐ㇟䛻䛺䜙䛺䛛䛳䛯.
**䜾䝸䝩䝃䞊䝖4✀䠖䜰䞁䝰䝙䜴䝮ሷ䚸䜲䝋䝥䝻䝢䝹䜰䝭䞁ሷ䚸䜹䝸䜴䝮ሷ䚸䝘䝖䝸䜴䝮ሷ✀㢮㎰⸆ྡึᖺᗘ䠄2021ᖺ
ᖺᗘ䠅䛾㎰⸆෌ホ౯14✀㎰Ỉ┬඲ᩥ䛻䜘䜛㐺ྜᛶཬ䜃ಙ㢗ᛶ䛻ᇶ䛵䛟ศ㢮 㐺ྜᛶ䛺䛧䜢㝖䛝䚸༊ศa,b,c䛻ศ㢮༊ศ䠽䠖䝸䝇䜽ホ౯䛻฼⏝ྍ⬟䛸ุ᩿䛥䜜䜛ᩥ⊩༊ศ䠾䠖䝸䝇䜽ホ౯䛾⿵㊊䝕䞊䝍䛸䛧䛶฼⏝䛜ྍ⬟䛸᝿ᐃ䛥䜜䜛ᩥ⊩༊ศ䠿䠖䠽ཪ䛿䠾䛻ศ㢮䛥䜜䛺䛔ᩥ⊩ᅜ㝿ᶵ㛵䜔Ḣ⡿䛾ホ౯ᶵ㛵䛾ホ౯᭩䛻ᘬ⏝䛥䜜䛶䛔䜛ᩥ⊩䛿䚸ホ౯䛾ᑐ㇟䛸䛩䜛→㑅ู䛥䜜㝖እ䛥䜜䛯ㄽᩥ᝟ሗ䛿䚸ሗ࿌᭩䛻୍ษグ㍕䛥䜜䛺䛔⾲㢟䛸ᴫせ䛻䜘䜛㐺ྜᛶ䛾☜ㄆ ᫂䜙䛛䛻ホ౯┠ⓗ䛻㐺ྜ䛧䛺䛔ᩥ⊩䛾㝖እ

1210

䠍䠊Kitauchi S, et al. J Vet Med Sci. 2021 Apr 24;83(4):746-753.
Effects of in utero and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of theneonicotinoid clothianidin on the reproductive organs of female mice.
2. Maeda M, et al..J Vet Med Sci. 2021 Apr 3;83(3):542-548.
Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid
pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental
stages in male mice.
3. Onaru K, et al. J Vet Med Sci. 2020 Mar 24;82(3):360-372.
Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats.
4. Yanai S, et al. J Vet Med Sci. 2017 Jul 7;79(7):1196-1203.
Prenatal and early postnatal NOAEL-dose clothianidin exposure leads to a reduction of germ cells in juvenile
male mice.
5. Hirano T, et al. J Vet Med Sci. 2015 Oct;77(10):1207-15.
The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in malemice.
6. Hoshi N, et al. Biol Pharm Bull. 2014;37(9):1439-43.
Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides.
7. Tokumoto J, et al. J Vet Med Sci. 2013;75(6):755-60.
Effects of exposure to clothianidin on the reproductive system of male quails.
ᫍඛ⏕᪉䛾◊✲䛷䛿䚸↓ẘᛶ㔞䠄᭷ᐖ䛺ᙳ㡪䛜ㄆ䜑䜙䜜䛺䛔᭱኱ᢞ୚㔞䠅䛷␗ᖖ䛜ㄆ䜑䜙䜜䜛ㄽᩥ䛜䛔䛟䛴䜒䛒䜛䚹䠒䠈䠓䛾㫽䛾⏕Ṫ⣔䜈䛾◊✲䛷䛿䚸᪥ᮏ䛾ᮒ㮛䜔䝁䜴䝜䝖䝸䛾⦾Ṫ䜢ጉ䛢䛶䛔䜛䛣䛸䜢♧၀䛧䛯㔜せ䛺ㄽᩥ䚹䜽䝻䝏䜰䝙䝆䞁ሗ࿌᭩ ୙㐺ษ䛻๐㝖䛥䜜䛶䛔䛯஦౛᳨⣴ᮇ㛫㻝㻡ᖺ䠄ึᖺᗘ㻞㻜㻜㻢ᖺ㻠᭶㻝᪥䡚㻞㻜㻞㻝ᖺ㻟᭶㻟㻝᪥䠅๓ᚋ䛾㔜せ䛺ㄽᩥ䛿ᑐ㇟እホ౯ጤဨ䛜せồ䛩䜜䜀䚸᪂䛯䛺ᩥ⊩䛜౑䜟䜜䜛䛸䛧䛶䛔䜛䛜䚸ᐇ⾜䛥䜜䜛䛛䠛䠛ᩥ⊩䛾཰㞟䛿ㄡ䛜䜔䛳䛶䜒ྠ䛨䛰䛜䚸㑅ู䜔ホ౯䛾㐣⛬䜢㎰⸆䝯䞊䜹䞊䛜බᖹ䛻䛷䛝䜛䛾䛛䠛䠛㎰Ỉ┬䛿䚸䛂䜺䜲䝗䝷䜲䞁䛻ᚑ䛳䛶཰㞟䚸㑅ᢥ➼䛥䜜䛯䜒䛾䛷䛒䜛䛛䜢☜ㄆ䛧䛯ୖ䛷䚸㎰ᴗ㈨ᮦᑂ㆟఍䜈䛾ㅎၥ䚸㣗ရᏳ඲ጤဨ఍䜈䛾ホ౯せㄳཬ䜃⎔ቃ┬䜈䛾㏦௜䜢⾜䛳䛯䛃䛸䛧䛶ሗ࿌᭩䜢බ㛤䛧䛶䛔䜛䚹㼔㼠㼠㼜㼟㻦㻛㻛㼣㼣㼣㻚㼙㼍㼒㼒㻚㼓㼛㻚㼖㼜㻛㼖㻛㼚㼛㼡㼥㼍㼗㼡㻛㼟㼍㼕㼔㼥㼛㼗㼍㻛㼗㼛㼡㼔㼥㼛㼡㼎㼡㼚㼗㼑㼚㻚㼔㼠㼙㼘㻌䠏䠊 ᩥ⊩䛾ホ౯䠎䠊 ᩥ⊩䛾㑅ูhttps://www.maff.go.jp/j/council/sizai/nouyaku/attach/pdf/36-16.pdf
1. ᩥ⊩䛾཰㞟᳨⣴䝃䜲䝖䠄ⱥ䞉࿴ㄽᩥPubmed , Web of Science, CiNii䛺䛹䠅䛷㎰⸆ྡ䛻䜘䜛᳨⣴
4ศ㔝䛻㛵䛩䜛⤠䜚㎸䜏 䐟䝠䝖䛻ᑐ䛩䜛ẘᛶ䚸䐠㎰స≀ཬ䜃␆⏘≀䜈䛾ṧ␃䚸䐡⏕ά⎔ቃື᳜≀ཬ䜃ᐙ␆䛻ᑐ䛩䜛ẘᛶ䚸䐢⎔ቃືែබ⾲ᩥ⊩䛾䜺䜲䝗䝷䜲䞁䝙䝁䝏䞁䠄ẘ≀ᣦᐃ䠅

ཎయ

78
7.5*

>5• 䝤䝍䜽䝻䞊䝹 ௧࿴5ᖺ4᭶27᪥ ADI:0.01mg/kg/day, ARfD: 0.49mg/kg
ADI䛿2011ᖺ䛾ホ౯᭩䛸ྠ䛨䚸ARfD䜢᪂䛯䛻タᐃ• 䜲䝋䝏䜰䝙䝹 ௧࿴5ᖺ6᭶8᪥ ADI:0.028mg/kg/day, ARfD䛿タᐃ䛾ᚲせ䛺䛧2009ᖺ䛾ホ౯᭩䛸ྠ䛨䚹ホ౯᭩䠄᱌䠅䜢୍㒊ಟṇ䛸グ㍕䚹
ADI:୍᪥ᦤྲྀチᐜ㔞䠄ẖ᪥୍⏕ᾭ䛻䜟䛯䛳䛶ᦤྲྀ䛧䛶䜒೺ᗣ䛻 ᝏᙳ㡪䛜䛺䛔䛸ุ᩿䛥䜜䜛㔞䠅

4. Tomizawa M & Casida JE. Selective toxicity of neonicotinoids attributable to specificity of insect andmammalian nicotinic receptors. Rev Entomol. 2003;48:339 64.

5 Tomizawa M & Casida JE. Desnitro imidacloprid activates the extracellular signal regulated kinase cascade
via the nicotinic receptor and intracellular calcium mobilization in N1E 115 cells.Toxicol Appl Pharmaco. 2002
Nov 1;184(3):180 6.

䜲䝭䝎䜽䝻䝥䝸䝗䛜䝠䝖䞉䝙䝁䝏䞁ᛶཷᐜయ䛻཯ᛂ䛩䜛䛣䛸䜢♧䛧䛯ㄽᩥ䛜ྵ䜎䜜䛶䛔䛺䛔
Loser D et al. Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons.
Arch Toxicol. 2021; 95(6): 2081–2107.

䛸᥎ᐃ䛥䜜䜛㔞䠅

AR䡂D:ᛴᛶཧ↷⏝㔞䠄24᫬㛫ཪ䛿䛭䜜䜘䜚▷䛔᫬㛫⤒ཱྀᦤྲྀ䛧䛯ሙྜ䛻೺ᗣ 䛻ᝏᙳ㡪䜢♧䛥䛺䛔• 䝏䜸䝧䞁䜹䝹䝤 ௧࿴5ᖺ4᭶27᪥ ADI:0.009mg/kg/day, ARfD:1mg/kg
ADI䛿2010ᖺ䛾ホ౯᭩䛸ྠ䛨䚸ARfD䜢᪂䛯䛻タᐃ䚹

3 Wang A et al. Assessment of imidacloprid related exposure using imidacloprid ol efin and desnitro imidacloprid:
Neonicotinoid insecticides in human urine in Wuhan, China. Environ Int. 2020 Aug;141:105785.

15• 䝏䝣䝹䝄䝭䝗 ௧࿴5ᖺ3᭶17᪥ ADI䠖0.014mg/kg/day , AR䡂D:䠌.25mg/kg䛿
2019ᖺ䛾㎰⸆ホ౯᭩䛸ྠ䛨䚹ホ౯᭩䠄᱌䠅䜢୍㒊ಟṇ䛸グ㍕䚹

2. Loser D et al. Acute effects of the imidacloprid metabolite desnitro imidacloprid on human nACh receptors
relevant for neuronal signaling. Arch Toxicol. 2021 Dec;95(12):3695 3716.

㣗ရᏳ඲ጤဨ఍䛷෌ホ౯䛜⤊஢䛧䛯㎰⸆௨ୗ䛾4ᡂศ䛾㎰⸆䛿䚸㣗ရᏳ඲ጤဨ఍䞉㎰⸆➨୍ᑓ㛛ㄪᰝ఍䠄㠀බ㛤䠅䠍,2ᅇ䛷ᑂ㆟⤊஢13䝕䝇䝙䝖䝻䞉䜲䝭䝎䜽䝻䝥䝸䝗௦ㅰ≀

LD50 mg/kg

45

LD50 mg/kg

0.05

1614䜲䝭䝎䜽䝻䝥䝸䝗䛜䝠䝖䞉䝙䝁䝏䞁ᛶཷᐜయ䛻㻌཯ᛂ䛩䜛䛣䛸䜢♧䛧䛯䝠䝖⏤᮶⚄⤒⣔⣽⬊䜢⏝䛔䛯ㄽᩥ䛜୙㊊䚹
ヲ䛧䛟䛿䚸᪥ᮏෆศἪ᧠஘≀㉁Ꮫ఍䝙䝳䞊䝇䝺䝍䞊㻞㻡䠉㻠ྕ䜢ཧ↷䚹 㼔㼠㼠㼜㻦㻛㻛㼖㼟㼑㼐㼞㻚㼛㼞㼓㻛䜲䝭䝎䜽䝻䝥䝸䝗䠄๻≀ᣦᐃ䠅

㎰⸆䛸௦ㅰ≀䛾ྡ⛠ཎయ✀㢮့ங㢮䛻ẘᛶ䛾㧗䛔௦ㅰ≀䝕䝇䝙䝖䝻䞉䜲䝭䝎䜽䝻䝥䝸䝗䛾ㄽᩥ䛜ᑡ䛺䛟䛸䜒5ሗ䚸ሗ࿌᭩䛻୍ษ᝟ሗ䛜䛺䛔䚹䛣䜜䜙䛾ㄽᩥ䛿့ங㢮䜈ẘᛶ䜔⎔ቃᙳ㡪䛻䛴䛔䛶䚸㔜せ䛺䝕䞊䝍䜢♧䛧䛶䛔䜛䚹䜺䜲䝗䝷䜲䞁䛻䛿䚸䛂Ᏻ඲ᛶホ౯䛾ୖ䛷ᚲせ䛾䛒䜛௦ㅰ≀䚸ศゎ≀➼䞉䞉䛜䛒䜛ሙྜ䛻䛿䚸䞉䞉ᑐ㇟䛸䛩䜛䛃䛸䛧䛶䛚䜚䚸ሗ࿌᭩䛻ධ䜜䜛䜉䛝䛰䛜䚸㝖እ䛥䜜䛶䛔䜛䚹᪻⹸䜈䛾⮴Ṛẘᛶ䠄䜲䜶䝞䜶䠅့ங㢮䜈䛾⮴Ṛẘᛶ䠄䝬䜴䝇䠅༊ศa䛿18ሗ䚸༊ศ䠾䛿44ሗ䚸༊ศc䛿51ሗ䝞䜲䜶䝹䜽䝻䝑䝥䝃䜲䜶䞁䝇♫ሗ࿌᭩䛾஦౛ ᳨⣴ᮇ㛫䠄2006ᖺ1᭶1᪥䡚2021ᖺ3᭶31᪥䠅ሗ࿌᭩䛿ⱥㄽᩥ᳨⣴䝃䜲䝖䛷imidacloprid䜢᳨⣴䛩䜛䛸䚸9115ሗ䛾ㄽᩥ䛜䝠䝑䝖䛧䚸䛂➨୍ẁ㝵䛾㐺ྜᛶ䛜䛺䛔ᩥ⊩7210ሗ䛸ᾏእ䝸䝇䜽ホ౯䛷౑⏝䛥䜜䛯708ሗ䜢๐㝖䛧䛶䚸1197ሗ䛜ṧ䜛䛃䛸䛧䚸1197ሗ䛻䛴䛔䛶䛿ㄽᩥ᝟ሗ䛸ホ౯䜢グ㍕䛧䛶䛔䜛䚹䜲䝭䝎䜽䝻䝥䝸䝗බ⾲ᩥ⊩ሗ࿌᭩䛾୙㐺ษ䛺஦౛့ங㢮䜈䛾ẘᛶ䛜㧗䛔௦ㅰ≀䝕䝇䝙䝖䝻䞉䜲䝭䝎䜽䝻䝥䝸䝗䛻㛵䛩䜛㔜せ䛺ㄽᩥ᝟ሗ䛜୍ษグ㍕䛥䜜䛶䛔䛺䛔
1. Passoni A et al. An integrated approach, based on mass spectrometry, for the assessment of imidacloprid
metabolism andpenetration into mouse brain and fetus after oral treatment. Toxicology. 2021 Oct;462:152935.

䜲䝭䝎䜽䝻䝥䝸䝗䛾බ⾲ᩥ⊩ሗ࿌᭩䛾୙㐺ษ䛺஦౛䠎䠊Ohno S, et al. Toxicol Lett. 2020 Apr 1;322:32-38
Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites inmice.
3. Hirano T, et al. Toxicol Appl Pharmacol. 2019 Nov 15;383:114777.
Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SHSY5Y cells.
4. Hirano T, et al. Toxicol Lett. 2018 Jan 5;282:57-63.
NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with humanaudible vocalizations in male mice in a novel environment.

䛣䛾ㄽᩥ䛻䛴䛔䛶䚸ሗ࿌᭩䛻᭩䛛䜜䛶䛔䛯௨ୗ䛾ホ౯ෆᐜ䛿඲䛶㛫㐪䛔䛂⿕㦂≀㉁᝟ሗ䛜䜋䛸䜣䛹䛺䛔䛃 → ⿕㦂≀㉁᝟ሗ䛿䚸ⴭ⪅䜙䛾௨๓䛾ㄽᩥ䛷ヲ䛧䛟グ㍕䛥䜜䛶䛚䜚䚸ᘬ⏝䛧䛶䛔䜛䛂ᑐ↷ヨ㦂䛜䛺䛔䛃 → ᑐ↷ヨ㦂䛿ᐇ᪋䛥䜜䛶䛔䜛䛂1⩌ఱ༉䛷ᢞ୚䛧䛯䛛୙᫂䛃 → 1⩌5䠈6༉䛸グ㍕

ᾏእ䛾䝸䝇䜽ホ౯ᶵ㛵䛷౑䜟䜜䛯ㄽᩥ4ሗ䛜඲䛶༊ศC䛸䛥䜜䛶䛚䜚䚸ホ౯ෆᐜ䜒୙㐺ษ䚹
1䠊Hirano T, et al. Toxicol Lett. 2021 May 15;342:95-103. Aging-related changes in the sensitivity of behavioral
effects of the neonicotinoid pesticide clothianidin in male mice.

䜽䝻䝏䜰䝙䝆䞁ሗ࿌᭩ ୙㐺ษ䛺஦౛ᑂ㆟ෆᐜ䛿▱ⓗ㈈⏘ಖㆤ䛾䛯䜑㠀බ㛤䝸䝇䜽ホ౯䛾ᐇ౛֐ૢ҈સ‫਼ܐ‬ʤ‫ݺ‬ରࠫ10͉झࠫ10ʥͱࢋड़͢ɼ
࠹ఁ஍Ν҈સ‫਼ܐ‬ʤʹ100ʥͲׄΖ೸༂‫ݬ‬ର͹સͱ͹ಡ੓ࢾ‫ݩ‬Ͷͯ͏ʀৱ඾శՅ෼͹࢘༽ྖʀ೸༂͹࢔ཻ‫خ‬६஍౵͹અఈͶ‫͠༽׈‬ΗΖ㎰⸆ཎయ䛾ẘᛶヨ㦂⤖ᯝ䜢ᇶ䛻䚸Ᏻ඲ᛶ䛾ᇶᮏ䛸䛺䜛୍᪥ᦤྲྀチᐜ㔞䛜Ỵᐃ䛥䜜䜛䚹䚸⿵ຓᡂศ䜢ྵ䜐㎰⸆〇๣䛾ẘᛶヨ㦂䛿䚸ᛴᛶẘᛶ䛾䜏ᚲせ䛸䛥䜜䛶䛔䜛䛜䚸Ᏻ඲ᛶ䛾ᇶ♏䝕䞊䝍䛸䛿䛺䛳䛶䛔䛺䛔䚹ʻ 0.01 mg/kg/dayϐφ͹ADIōōō䝠䝖䛜⏕ᾭ䛻䜟䛯䜚ẖ᪥ᦤྲྀ䛧⥆䛡䛶䜒᭷ᐖస⏝䜢♧䛥䛺䛔୍᪥䛒䛯䜚䛾㔞Ҳೖઃख‫ڒ‬༲ྖʤADI: Acceptable Daily Intakeʥ͹݀ఈōōōCࢾ‫ݩ‬‫ ݩ‬ʁ 50 mg/kg/dayBࢾ‫ݩ‬‫ ݩ‬ʁ 1 mg/kg/dayAࢾ‫ݩ‬‫ ݩ‬ʁ 100 mg/kg/dayōōōಊ෼ࢾ‫ݩ‬౵Ͳ༙֒͵Ӫ‫͗ڻ‬೟ΌΔΗ͵͏࠹୉౦༫ྖ

ໃಡ੓ྖʤNOAELʁNo-Observed Adverse Effect Levelʥ͹ࢋड़19⚄ᡞ኱䞉ᫍಙᙪᩍᤵ㈨ᩱ䜘䜚ᨵኚ17䝤䝍䜽䝻䞊䝹䛷䛿䚸ᩥ⊩᳨⣴ᮇ㛫௨๓䚸ఱ䜢䛹䜜䛠䜙䛔ᑂ㆟䛧䛶䛔䜛䛾䛛䚸
1990ᖺ௦䛻့ங㢮䜈䛾ẘᛶ䛜」ᩘ
୍ษ䜟䛛䜙䛺䛔
ሗ࿌䛥䜜䛶䛔䜛䛜䚸ሗ࿌᭩䛻䛿グ㍕䛥
䜜䛶䛔䛺䛔㎰⸆䛾Ᏻ඲ᇶ‽䛾Ỵ䜑᪉䛻䛿ၥ㢟䛜䛒䜛ϐφͶଲͤΖ҈સ੓▱ⓗ㈈⏘ಖㆤ䛾䛯䜑㎰⸆ཎయ䛾⃰ᗘ䠄ppm)䝫䝸䝉䜽䝖䖃䜰䝉䝍䝭䝥䝸䝗 䚽

Mesnage et al,Biomed. Res. Int. 2014㻞㻜• ㎰⸆䛾ẘᛶヨ㦂䛿䚸ཎయ䛷ㄪ䜉䜙䜜䚸䛭䛾⤖ᯝ䜢ඖ䛻ᇶ‽䛜Ỵ䜎䜛䚹㎰⸆෌ホ౯䛷䜒⿵ຓᡂศ䛿ᑐ㇟እ䚹• ᐇ㝿䛻౑⏝䛥䜜䛶䛔䜛㎰⸆〇๣䛾↓ẘᛶ㔞䛛䜙䚸チᐜ㔞䜢ィ⟬䛩䜉䛝䛷䛿䛺䛔䛛䚹• 〇๣䛾✀㢮䛜ከ䛟䛶䛷䛝䛺䛔䛺䜙䚸Ᏻ඲ಀᩘ䜢100ಸ䜘䜚㧗䛔್䛻䛩䜛ᚲせ䛜䛒䜛䛾䛷䛿䛺䛔䛛䚹• 䝷䜴䞁䝗䜰䝑䝥䛰䛡䛷䛺䛟㎰⸆〇๣䖃䛿䚸㎰⸆ཎయ䚽䜘䜚䜒䚸ẘᛶ䛜㧗䛔䜒䛾䛜ከ䛔䚹• ㎰⸆〇๣䛻䛿䚸⏺㠃άᛶ๣䚸㜵⭉๣䚸⁐๣䚸ங๣䛺䛹⿵ຓᡂศ䛜ධ䜜䜙䜜䜛䛜䚸௻ᴗ⛎ᐦ䛷ᮍබ㛤䚹• ⿵ຓᡂศ䛾䛺䛛䛻䛿䚸ẘᛶ䛾㧗䛔䜒䛾䛜䛒䜛䚹䠦䠡䠣3䠖䝠䝖⫾┙⏤᮶⣽⬊⣽咁䠂⬊咂叏⏕ṧ⋡䝷䜴䞁䝗䜰䝑䝥 䖃䜾䝸䝩䝃䞊䝖 䚽㎰⸆ཎయ䜘䜚䜒ẘᛶ䛜㧗䛔㎰⸆〇๣

18• ㎰⸆䛾ẘᛶヨ㦂䛻୙ഛẘᛶヨ㦂䛻䚸⎔ቃ䝩䝹䝰䞁స⏝䚸㧗ḟ⬻ᶵ⬟䜈䛾ᙳ㡪䚸」ྜᙳ㡪䚸3ୡ௦௨㝆䛾⥅ୡ௦ᙳ㡪䛺䛹䛜ධ䛳䛶䛔䛺䛔䚹㎰⸆〇๣䛻ྵ䜎䜜䜛⿵ຓᡂศ䛾ẘᛶ䛿⪃៖䛥䜜䛶䛔䛺䛔䚹• 䛭䜜䛮䜜䛾ᑂ㆟఍䛾ጤဨ䛾㑅௵䛜୙᫂░• ᑂ㆟ෆᐜ䛜ཎ๎䚸ᮍබ㛤• බ⾲ᩥ⊩䛾཰㞟䚸㑅ᢥ䚸ホ౯䜢䚸฼┈┦཯䛾䛒䜛㎰⸆䝯䞊䜹䞊䛜ᐇ᪋䛩䜛䛸䚸୙㒔ྜ䛺ᩥ⊩䛜䜟䛛䜙䛺䛔䜘䛖๐㝖䛥䜜䜛ྍ⬟ᛶ䛜䛒䜛䚹ᐇ㝿䚸䝯䞊䜹䞊䛜సᡂ䛧㎰Ỉ┬䛜☜ㄆ䛧䛯බ⾲ᩥ⊩ሗ࿌᭩䛷䛿䚸䜽䝻䝏䜰䝙䝆䞁䚸䜲䝭䝎䜽䝻䝥䝸䝗䛾䜘䛖䛻䚸୙㐺ษ䛺஦౛䛜☜ㄆ䛥䜜䛯• ෌ホ౯䛾䝅䝇䝔䝮䛷䚸୍ぢᨵⰋ䛥䜜䛯䜘䛖䛻䜏䛘䜛䛜䚸ၥ㢟䛜ከ䚻᭷䜚㎰⸆෌ホ౯䛷Ᏻ඲ᛶ䛿☜ಖ䛷䛝䜛䛾䛛䠛EU䛷䛿ཝ䛧䛟つไ㎰⸆䛿ከ✀㢮䛾ẘᛶヨ㦂䜢䜔䛳䛶䛔䜛䛜䚸ᇶ‽ෆ䛺䜙Ᏻ඲䛸䛿Ỵ䛧䛶䛔䛘䛺䛔䚹⌧௦♫఍䛷䝊䝻䝸䝇䜽䛿㞴䛧䛔䛜౑⏝㔞ῶ䜙䛩䛣䛸䛜ᚲせ䛷䛿䛺䛔䛛䚹䠑䠅ᇶ‽್䜢Ỵ䜑䜛ẘᛶヨ㦂䛿㎰⸆ཎయ䛷䚸ᐇ㝿䛻౑⏝䛩䜛〇๣䛷䛿䛺䛔䚹 ⿵ຓᡂศ䛾ẘᛶ䛜⪃៖䛥䜜䛶䛔䛺䛔ᐇ㝿䛻䛿ከ✀㢮䛾㎰⸆䛻᭚㟢䛧䛶䛔䜛䛜䚸」ྜẘᛶ䛿ㄪ䜉䜙䜜䛶䛔䛺䛔䚹

䠐䠅」ᩘ䛾㎰⸆䛾」ྜ᭚㟢ᙳ㡪䜾䝸䝩䝃䞊䝖䛿ື≀ᐇ㦂䛷䚸3ୡ௦䚸4ୡ௦䛻೺ᗣ㞀ᐖ䜢㉳䛣䛧䛯

䠏䠅 3ୡ௦௨㝆䜈䛾⥅ୡ௦ᙳ㡪䚸 DNA䝯䝏䝹໬␗ᖖᶵ⬟䜢ㄪ䜉䜛䛻䛿୙༑ศྂ䛔᪉ἲ䛷⬻㧗ḟᶵ䠎䠅Ⓨ㐩⚄⤒ẘᛶ 2019ᖺᖺ4᭶௨㝆ヨ㦂㡯┠䛻ධ䜜䜙䜜䛯䛜ᚲ㡲䛷䛿䛺䛟䚸䠍䠅⎔ቃ䝩䝹䝰䞁స⏝㎰⸆Ⓩ㘓䛾ẘᛶヨ㦂䛷⪃៖䛥䜜䛶䛔䛺䛔㡯┠European Food Safety Authority:EFSA journal, 13, 4303䠄2015䠅䜘䜚ᘬ⏝https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/j.efsa.2015.4303

POEA䛿⾲䛾ẘᛶヨ㦂䛷䛿䚸䜾䝸䝩䝃䞊䝖ཎయ䜘䜚4.2䡚166.7ಸ㧗䛔ẘᛶ䜢♧䛧䛯䚹Ḣᕞ㣗ရᏳ඲ᶵ㛵䛿䚸⿵ຓᡂศ
POEA䛾ẘᛶ䜢ㄪ䜉䛶බ㛤䛧䚸Ḣᕞጤဨ఍䛿POEA䛾౑⏝䜢⚗Ṇ䛧䛯䚹↓ẘᛶ㔞䠖䛒䜛≀㉁䛻䛴䛔䛶ẘᛶヨ㦂䜢⾜䛳䛯᫬䚸᭷ᐖᙳ㡪䛜ㄆ䜑䜙䜜䛺䛛䛳䛯᭱኱䛾ᢞ୚㔞䜢♧䛩䚹ึᮇ䛾䝷䜴䞁䝗䜰䝑䝥䛾⿵ຓᡂศศ㻼㻻㻱㻭㻭䛾㧗ẘᛶ23䜶䝏䝺䞁䜾䝸䝁䞊䝹䝰䝜䜶䝏䝹䜶䞊䝔䝹䜰䝉䝔䞊䝖䠄ูྡ䝉䝻䝋䝹䝤䜰䝉䝔䞊䝖䠅䜶䝏䝺䞁䜾䝸䝁䞊䝹䝰䝜䝯䝏䝹䜶䞊䝔䝹䠄ูྡ䝯䝏䝹䝉䝻䝋䝹䝤䠅䜶䝏䝺䞁䜾䝸䝁䞊䝹䝰䝜䝯䝏䝹䜶䞊䝔䝹䜰䝉䝔䞊䝖䜶䝢䜽䝻䝻䝠䝗䝸䞁䜻䝜䝸䞁䜽䝸䝋䝍䜲䝹䠄䜰䝇䝧䝇䝖ᡂศ䠅䜽䝻䝅䝗䝷䜲䝖䠄䜰䝇䝧䝇䝖ᡂศ䠅㖔Ἔ䠄㧗ᗘ䛻⢭〇䛥䜜䛯䜒䛾䜢㝖䛟䚹䠅1䞉2䝆䜽䝻䝻䜶䝍䞁䠄ูྡ஧ሷ໬䜶䝏䝺䞁䠅䠐䝩䜴㓟䝘䝖䝸䜴䝮≀㉁ྡ⛠䜰䜽䝸䝹䜰䝭䝗䜰䝰䝃䜲䝖䠄䜰䝇䝧䝇䝖ᡂศ䠅䠍-䜶䝏䝹䝢䝻䝸䝆䞁-䠎-䜸䞁䜶䝏䝺䞁䜸䜻䝅䝗䜶䝏䝺䞁䜾䝸䝁䞊䝹䝰䝜䜶䝏䝹䜶䞊䝔䝹䠄ูྡ䝉䝻䝋䝹䝤䠅

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䝙䝖䝻䝧䞁䝊䞁
1䞉3―䝤䝍䝆䜶䞁䝣䝍䝹㓟䝆䜲䝋䝤䝏䝹䝣䝍䝹㓟䝆―䝜䝹䝬䝹―䝤䝏䝹䝧䞁䝊䞁䝧䞁䝌䠷䠽䠹䝢䝺䞁䝩䝹䝮䜰䝭䝗䝩䝹䝮䜰䝹䝕䝠䝗䠪―䝯䝏䝹䝩䝹䝮䜰䝭䝗䠎―䝙䝖䝻䝥䝻䝟䞁

POEA≀㉁ྡ⛠䠐䝩䜴㓟䝘䝖䝸䜴䝮䠑Ỉ࿴≀䠐䝩䜴㓟䝘䝖䝸䜴䝮10Ỉ࿴≀䠪䞉䠪―䝆䝯䝏䝹䝩䝹䝮䜰䝭䝗13㓟໬8䝩䜴⣲䠎䝘䝖䝸䜴䝮䠐Ỉ࿴≀⋇⬡䜰䝹䜻䝹䜰䝭䞁䛾䜶䝖䜻䝅໬≀䝎䝙㥑㝖๣䠄ᅜෆ䛾㎰⸆Ⓩ㘓䛺䛧䠅ᐙᗞ⏝䛻౑⏝୰౑⏝୰䝇䝭䝇䝸䞁䠄EU䛷䛿ẅ⹸๣䠅

ኻຠ 2009౑⏝୰⮯໬䝯䝏䝹䠄ୡ⏺䛷⚗Ṇ䛜㐍䜐䠅 ኻຠ 2011ᅵተ⇺↮๣ 䠄䜸䝌䞁ᒙ◚ቯ䠅౑⏝୰䝥䝻䝟䝙䝹

㝖ⲡ๣

ኻຠ 2011䝆䜴䝻䞁㝖ⲡ๣

౑⏝୰㝖ⲡ๣

ኻຠ 2018㝖ⲡ๣౑⏝୰
䜰䝉䝖䜽䝻䞊䝹㝖ⲡ๣ኻຠ 2008䜰䝷䜽䝻䞊䝹㝖ⲡ๣౑⏝୰䝬䞁䝊䝤ẅ⳦๣

ኻຠ 2004౑⏝୰ኻຠ 2014

ኻຠ 2004౑⏝୰ኻຠ 2017䝅䝬䝆䞁 (CAT)䝏䝷䜴䝮ẅ⳦๣౑⏝୰

ኻຠ 2006䜰䝖䝷䝆䞁䝬䞁䝛䝤ẅ⳦๣౑⏝୰౑⏝୰䝥䝻䝅䝭䝗䞁ẅ⳦๣౑⏝୰
ኻຠ 2007౑⏝୰䝣䜵䝙䝖䝻䝏䜸䞁᭷ᶵ䝸䞁⣔ẅ⹸๣౑⏝୰ኻຠ 2000ኻຠ 2006䝨䝹䝯䝖䝸䞁䝢䝺䝇䝻䜲䝗⣔ẅ⹸๣᪥ᮏኻຠ 2007EU

ኻຠ 2014䜹䝹䝞䝸䝹 (NAC)㎰⸆ྡ䜹䝹䝞䝯䞊䝖⣔ẅ⹸๣㎰⸆䛾✀㢮EU䛷ኻຠ῭䜏䛷⎔ቃ䝩䝹䝰䞁స⏝䛾ሗ࿌䛥䜜䛶䛔䜛㎰⸆24ே䛷䛿䚸Ꮚ䛹䜒䛾ᡂ㛗䛻ᝏᙳ㡪䜢ཬ䜌䛧Ⓨ㐩㞀ᐖቑຍ䚸⢭Ꮚῶᑡ䚸୙ዷ䜢㉳䛣䛩ྍ⬟ᛶ䛜ᠱᛕ䛥䜜䛶䛔䜛䚹⎔ቃ䝩䝹䝰䞁䠄ෆศἪᨩ஘≀㉁䠅䛿䚸⛉Ꮫⓗ䛻᫂䜙䛛䛻䛺䛳䛶䛚䜚䚸Ḣ⡿䛷䛿つไ䛜ᙉ໬䛥䜜䛶䛔䜛䚹• ㎰Ỉ┬䛿䚸2022ᖺ6᭶䚸⣙1200✀䛾⿵ຓᡂศ䛾䛖䛱䚸Ḣ⡿䛷᪤䛻⚗Ṇ䛥䜜䛶䛔䜛Ⓨ䛜䜣ᛶ䛺䛹㧗ẘᛶ䛾30✀䜢౑⏝⚗Ṇ䛻䛩䜛┬௧᱌䜢ᥦ᱌䛧䛯䚹䛯䛰䛧2025ᖺ10᭶1᪥䜎䛷౑⏝ྍ䚹• 㟷ᯟ䛷ᅖ䛳䛯⿵ຓᡂศ䜢౑⏝䛧䛶䛔䜛㎰⸆〇๣䛜䚸⌧ᅾ䛷䜒㈍኎䞉౑⏝䛥䜜䛶䛔䜛䛜䚸㎰Ỉ┬䛿೺ᗣᙳ㡪䛿䛺䛔䠄䠛䠅䛸䛧䛶䛔䜛䚹┤䛠䛻౑⏝⚗Ṇ䛻䛩䜛䜉䛝䛷䛿䛺䛔䛛䚹• 30✀௨እ䛻䜒ẘᛶ䛾䛒䜛⿵ຓᡂศ䛜౑⏝䛥䜜䛶䛔䜛ྍ⬟ᛶ䛜䛒䜛䛜䚸⿵ຓᡂศ䛿⾲♧⩏ົ䛜䛺䛔䛯䜑䚸୙᫂䚹• Ḣ⡿䛷䛿⿵ຓᡂศ䛾つไ䜢㐍䜑䛶䛔䜛䚹

78
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612345⚗Ṇணᐃ䛾30✀䛾㎰⸆⿵ຓᡂศ

→ ฼┈┦཯䛾䛺䛔➨୕⪅䛜ᐇ᪋䛩䜛యไ䛜ᚲせཧ⪃䠊䜏䛹䜚䛾㣗ᩱ䝅䝇䝔䝮ᡓ␎

2050ᖺ
ᖺ䠛

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㎰⸆෌ホ౯䛻䛴䛔䛶䚸௒ᚋ䛾ື䛝䜢ὀど䛧䚸ၥ㢟Ⅼ䜢᫂䜙䛛䛻䛧䚸⥅⥆䛧䛯㆟ㄽ䛸⾜ືᥦ㆟䜢䟿• ㎰⸆䛾෌ホ౯䛷䛿䚸ண㜵ཎ๎䜢㐺⏝䛧䚸༴㝤ᛶ䛾䛒䜛㎰⸆䛿つไᙉ໬䞉⚗Ṇ䛧䛺䛡䜜䜀䛺䜙䛺䛔䚹⬤ᙅ䛺Ꮚ䛹䜒䜔⏕ែ⣔䜈䛾㔜኱䛺ᝏᙳ㡪䛜㉳䛣䛳䛶䛛䜙䛷䛿ྲྀ䜚㏉䛧䛜䛴䛛䛺䛔䚹• ෌ホ౯䛿ཎ๎15ᖺ ⛉Ꮫ䛿ᖖ䛻᭦᪂䛧䛶䛔䜛䛾䛷䚸᪂᝟ሗ䜢ྲྀ䜚ୖ䛢䜛බⓗ䝅䝇䝔䝮䛜ᚲせ䚹• ẘᛶヨ㦂䛛䜙⟬ฟ䛥䜜䜛୍᪥ᦤྲྀチᐜ㔞ADI䜔ṧ␃㎰⸆ᇶ‽䛾Ỵ䜑᪉䛻ぢ┤䛧䛜ᚲせ䚹䛺䛛䛷䜒䠝䠠䠥80䠂௨ୗ䛺䜙Ᏻ඲䛸䛩䜛䚸䠝䠠䠥ᩘ್⮳ୖ୺⩏䜢䛒䜙䛯䜑䜛ᚲせ䛜䛒䜛䚹• ⌧ᅾ䚸㎰⸆Ⓩ㘓䛻ᚲせ䛺ẘᛶヨ㦂䛿୙༑ศ䚹⎔ቃ䝩䝹䝰䞁స⏝䚸㧗ḟ⬻ᶵ⬟䜈䛾ᙳ㡪䚸」ྜẘᛶ䚸〇๣䛾⿵ຓᡂศ䛾ẘᛶ䛺䛹䛜⪃៖䛥䜜䛶䛔䛺䛔 → ẘᛶヨ㦂ἲ䛾ᢤᮏⓗ䛺ᨵኚ䛜ᚲせ• ෌ホ౯䛾ᑂ㆟䛺䛹䛜ཎ๎ᮍබ㛤▱ⓗ㈈⏘ಖㆤ䛾䛯䜑䛸䛧䛶䚸ᑂ㆟ෆᐜ䛿ཎ๎ᮍබ㛤→ බ㛤䛜ᚲせ෌ホ౯䛾ጤဨ䛾㑅௵䛜୙᫂ → බເ䛧䛶୍⯡ᕷẸ䜔ᾘ㈝⪅䛾ጤဨ䛜ᚲせ• බ⾲ᩥ⊩䛾཰㞟䚸㑅ᢥ䚸ホ౯㎰⸆ྲྀ⥾ἲᨵṇ䛻㎰⸆෌ホ౯ไᗘ䛜ᑟධ䛥䜜䛯䛣䛸䛿ホ౯䛷䛝䜛䛜䚸ၥ㢟䛜䛒䜛䚹㎰⸆෌ホ౯䛾ၥ㢟Ⅼ䛸ㄢ㢟ཧ⪃䠊䜏䛹䜚䛾㣗ᩱ䝅䝇䝔䝮ᡓ␎௦᭰䛻RNA㎰⸆䠛

4. ෆศἪ᧠஘≀㉁Ꮫ఍䝙䝳䞊䝇䝺䝍䞊 ㎰⸆≉ูྕ
http://jsedr.org/

1~3䛿⎔ቃ⬻⚄⤒⛉Ꮫ᝟ሗ䝉䞁䝍䞊HP
https://environmental-neuroscience.info/free-papers/entry53.html

䠍䠊㐲ᒣ༓᫓䚸ᮌᮧ-㯮⏣⣧Ꮚ䚸ᫍಙᙪ䠖㎰⸆䛾Ᏻ඲ᛶ䛸䝸䝇䜽ホ౯䚸⛉Ꮫ䠄ᒾἼ᭩ᗑ䠅 92䠖256䠉273䠄2022䠅䠎䠊㐲ᒣ༓᫓䚸ᮌᮧ-㯮⏣⣧Ꮚ䠖㎰⸆〇๣䛻ྵ䜎䜜䜛⿵ຓ๣䛾ẘᛶ⛉Ꮫ䠄ᒾἼ᭩ᗑ䠅92䠖689䠉691䠄2022䠅䠏䠊ᮌᮧ-㯮⏣⣧Ꮚ䠖㎰⸆〇๣䛻ྵ䜎䜜䜛⿵ຓᡂศ䛾ㅖၥ㢟 JEPA䝙䝳䞊䝇138ྕ

㎰⸆䛾ㅖၥ㢟䛻䛴䛔䛶䛿䚸௨ୗ䛾ᑠㄽᩥ䛺䛹䜢ཧ↷䛧䛶䛟䛰䛥䛔䚹඲䛶䝣䝸䞊䛷download䛷䛝䜎䛩䚹䛤Ύ⫈䛒䜚䛜䛸䛖䛤䛦䛔䜎䛧䛯䚹

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