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editor. Relationship of patch test results to anti-TSH receptor antibody titers in patients with Graves' disease: a population-based
study. Autoimmune orbitopathy has been reported in patients with autoimmune thyroid disease. The mechanism of thisassociation is unknown. We sought to determine whether the prevalence of orbitopathy is higher in patients with Graves' diseasethan in the general population and to correlate the prevalences of orbitopathy in our patients with thyroid autoimmunity, thepresence of antibodies to thyrotropin receptor (TRAb), clinical features of Graves' disease, or thyroid status. We studied a
population-based group of 251 patients with Graves' disease identified in a geographic area of 1.2 million people. Eighteenpercent (44 of 251) had orbitopathy according to the House-Brackmann system at initial presentation. There was a positive
correlation between the prevalence of orbitopathy and the presence of anti-thyroid-stimulating hormone receptor antibodies (rs= 0.18, p Q: General query for doing a simple conversion? I have built an iPhone app using the CCLayer-based cocos2d-iphone.
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In this study, we compared the expression of epidermal growth factor receptor (EGFR) and its ligands in fetal and adultpituitaries, with a focus on the corticotroph lineage. Ectopic expression of EGFR in corticotroph-derived AtT-20 cells induces amitogenic response to epidermal growth factor (EGF) and transforming growth factor (TGF)alpha. The cytoplasmic domain ofEGFR is critical for the mitogenic response, because EGFR deletion mutants lacking the cytoplasmic tail of EGFR in AtT-20cells fail to respond to TGFalpha. EGF receptor gene expression is highest in intermediate and basal lobe corticotrophs andlowest in anterior lobe corticotrophs. In situ hybridization revealed EGFR expression in intermediate and basal lobecorticotrophs, and the latter also expressed EGF and TGFalpha. Expression of EGFR family ligands, EGF and TGFalpha, hasbeen reported in the developing pituitary gland, but these ligands are generally considered to be locally acting trophic agents inthe developing pituitary gland. We show that intermediate and basal lobe corticotrophs express both EGF and TGFalpha and areboth EGFR- and TGFalpha-responsive. These results demonstrate that EG f678ea9f9e
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