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vascular reactivity and growth in SHR.
Angiotensin II (Ang II) has beenreported to play a role in the control ofvascular growth and reactivity. The
present study examined the effects ofprolonged treatment with the Ang II
type 1 receptor (AT1) receptor
antagonist losartan on the growth andreactivity of mesenteric resistancevessels of adult spontaneously
hypertensive rats (SHR) as a model ofhypertension. Following 7- to 8-weektreatment with losartan (10 mg/kg perday), vascular tissue was collected fromtreated and untreated normotensive
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Wistar-Kyoto (WKY) and SHR.
Vascular structure and function wereevaluated ex vivo in two vessel baths:
isolated perfused mesenteric arteries
and isolated perfused mesentericarterioles. Compared with untreated
WKY (mean +/- SE), losartan-treated
WKY showed a reduction in averagemean arterial pressure (by 25 +/- 2 mmHg) and mesenteric resistance vessels
showed a reduction in both media crosssectional area (by 36 +/- 2%) and wall
thickness (by 11 +/- 2%). In contrast,
mesenteric resistance vessel reactivity
to nitric oxide was increased and that tonoradrenaline was unchanged inlosartan-treated WKY compared with
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