iPLEX® HS Colon Panel for the MassARRAY® System

List of Mutations Detectable with the iPLEX® HS Colon Panel
GENE

BRAF

EGFR

KRAS

NCBI
Ref Seq

HGVS Nomenclature
CDS Mutation

AA Mutation

COSMIC ID

c.1406G>A

p.G469E

461

c.1781A>G

p.D594G

467

c.1799T>A

p.V600E476

c.1474A>C

p.S492R

236671c.1476C>A/G

p.S492R

236670c.175G>A

p.A59T546

c.175G>T

p.A59S

1235389c.176C>A

p.A59E547

c.176C>G

p.A59G

28518

c.181C>A

p.Q61K

549

c.181C>G

p.Q61E550

c.182A>C

p.Q61P

551c.182A>G

p.Q61R552

c.182_183AA>GT

p.Q61R

1168052c.182A>T

p.Q61L553

c.183A>C

p.Q61H554

c.183A>T

p.Q61H555

c.34_35GG>AT

p.G12I

34144

c.34_35GG>CT

p.G12L514

c.34_35GG>TA

p.G12Y

25081

c.34_35GG>TT

p.G12F

512

c.34_36GGT>TGG

p.G12W

36281

c.34G>A

p.G12S

517

c.34G>C

p.G12R

518

c.34_36GGT>AGA

p.G12R

249888NM_004333

NM_005228

NM_004985

For Research Use Only. Not for use in diagnostic procedures.
MassARRAY and iPLEX are registered trademarks of Agena Bioscience, Inc.
Agena Bioscience is a trademark of Agena Bioscience, Inc.
©2017 Agena Bioscience, Inc. All rights reserved.

1Agena Bioscience, Inc.
4755 Eastgate Mall
San Diego, CA 92121
Phone: +1.858.882.2800

Order Desk: +1.858.202.9301
Order Desk Fax: +1.858.202.9220
orderdesk@AgenaBio.com
Web: agenabioscience.com

US:
EU:
AP:
CN:

+1.877.4.GENOME+49.40.899676.0+61.7.3088.1600+86.21.6427.0566

51-20102R1.0

iPLEX® HS Colon Panel for the MassARRAY® SystemGENEKRASNCBIRef Seq

HGVS NomenclatureCDS Mutation

AA Mutation

COSMIC ID

c.34G>T

p.G12C516

c.350A>G

p.K117R

4696722c.351A>C

p.K117N

19940

c.351A>T

p.K117N

28519

c.35_36GT>AG

p.G12E

30566

c.35G>A

p.G12D521

c.35_36GT>AC

p.G12D

14209

c.35G>C

p.G12A522

c.35_36GT>CA

p.G12A

5413585

c.35G>T

p.G12V520

c.35_36GT>TC

p.G12V515

c.37_38GG>TT

p.G13F

1685355

c.37G>A

p.G13S

528

c.37G>C

p.G13R529

c.37_39GGC>CGT

p.G13R

526

c.37G>T

p.G13C527

c.38_39GC>AG

p.G13E30567

c.38_39GC>AA

p.G13E

87280

c.38G>A

p.G13D532

c.38_39GC>AT

p.G13D

531

c.38G>C

p.G13A

533

c.38G>T

p.G13V534

c.38_39GC>TT

p.G13V12721

c.436G>A

p.A146T

19404

c.436G>C

p.A146P

19905

c.437C>G

p.A146G

N/A

c.437C>T

p.A146V

19900

NM_004985

2For Research Use Only. Not for use in diagnostic procedures.
MassARRAY and iPLEX are registered trademarks of Agena Bioscience, Inc.
Agena Bioscience is a trademark of Agena Bioscience, Inc.
©2017 Agena Bioscience, Inc. All rights reserved.

iPLEX® HS Colon Panel for the MassARRAY® System

GENE

NRAS

NCBI
Ref Seq

HGVS Nomenclature
CDS Mutation

AA Mutation

COSMIC ID

c.175G>A

p.A59T578

c.176C>G

p.A59G

5878737c.181C>A

p.Q61K580

c.181C>G

p.Q61E581

c.182A>C

p.Q61P

582

c.182A>G

p.Q61R584

c.182A>T

p.Q61L583

c.183A>C

p.Q61H586

c.183A>T

p.Q61H585

c.349A>G

p.K117E

N/A

c.34G>A

p.G12S

563

c.34G>C

p.G12R

561

c.34G>T

p.G12C562

c.350A>G

p.K117R

N/A

c.351G>C

p.K117NN/A

c.351G>T

p.K117N

N/A

c.35G>A

p.G12D

564

c.35G>C

p.G12A

565

c.35G>T

p.G12V566

c.37G>A

p.G13S

571

c.37G>C

p.G13R

569

c.37G>T

p.G13C

570

c.38G>A

p.G13D

573

c.38G>C

p.G13A

575

c.38G>T

p.G13V574

c.436G>A

p.A146T

27174

c.436G>C

p.A146P

4172577

NM_002524

3

For Research Use Only. Not for use in diagnostic procedures.
MassARRAY and iPLEX are registered trademarks of Agena Bioscience, Inc.
Agena Bioscience is a trademark of Agena Bioscience, Inc.
©2017 Agena Bioscience, Inc. All rights reserved.

iPLEX® HS Colon Panel for the MassARRAY® SystemGENE

NRAS

PIK3CANCBI
Ref Seq

HGVS Nomenclature
CDS Mutation

AA Mutation

COSMIC ID

c.436G>T

p.A146S

N/A

c.437C>G

p.A146G

N/A

c.437C>T

p.A146V

4170228c.1624G>A

p.E542K

760

c.1633G>A

p.E545K

763

c.3140A>G

p.H1047R

775

c.3140A>T

p.H1047L

776

NM_002524

NM_006218

4For Research Use Only. Not for use in diagnostic procedures.
MassARRAY and iPLEX are registered trademarks of Agena Bioscience, Inc.
Agena Bioscience is a trademark of Agena Bioscience, Inc.
©2017 Agena Bioscience, Inc. All rights reserved.