NutriDyn™
PeriMenopause
SupportSupport for Balanced Hormones
During Perimenopause
PRACTITIONER EXCLUSIVE

PeriMenopause Support Supplementation
PeriMenopause Support is a comprehensive herbal formula aimed atpromoting healthy and balanced hormones during the time leading up
to menopause. Perimenopause can last for many years with numerous
symptoms leading up to permanent cessation of ovarian function.
PeriMenopause Support promotes healthy responses to the vasomotor,
sleep, mood, and cognitive functions commonly experienced during thisphase of mid-life.1,2
Supplementation with PeriMenopause Support may include these benefits:• Support for balanced hormones
• Support for healthy vasomotor response• Support for balanced moods
• Promotes cognitive performance and brain health• Supports restful sleeping habits and patterns
• Supports healthy bone metabolism• Promotes healthy stress response

How PeriMenopause Support Works
Perimenopause signals the end of the reproductive years for women. Progesterone and estrogen begin to wane while
the menstrual cycle becomes irregular and hormonal responses increase.3,4 Hot flashes are the most common sign of thistransition but some women may experience sleep disruptions, concerns with cognitive performance, and mood disturbances.3
The foundational ingredients of PeriMenopause Support are a proprietary herbal blend known as EstroG-100® containing
Angelica gigas nakai root, Cynanchum wilfordii root, and Phlomis umbrosa root. The coumarin compounds in Angelica
gigas nakai root help support healthy stress responses and may promote healthy nerve and cognitive functions.5,6
The high contents of total phenol and total flavonoids found in Cynanchum wilfordii root support healthy vasomotor
responses.7,8 The phytoestrogens found in Phlomis umbrosa root help support healthy bone metabolism.9,10

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The formula is complemented with ashwagandha root andmilk thistle seed. Ashwagandha supports healthy stressresponse due to its adaptogenic activity and anxiolyticeffect.11,12 Ashwagandha contains constituents such as
withanolides, sitoindosides, and alkaloids, to support thecells healthy oxidative stress response.11,12 Silymarin-richmilk thistle also supports healthy stress response and may
promote cognitive performance and brain health.13,14

Why Use PeriMenopause Support?
Research cited herein suggests that the nutrients inPeriMenopause Support may help support balanced
female hormones leading up to a woman’s time of
reproductive transition and promote overall health andwell-being.

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 30

Ingredients:
Estro G-100 Blend(Angelica gigas nakai root extract,
Cynanchum wilfordii root extract,
Phlomis umbrosa root extract)
Ashwagandha Root Powder
Milk Thistle Seed Powder®

Amount%DV*

500 mg*

500 mg
100 mg**Other Ingredients: Microcrystalline cellulose, vegetable
stearic acid, dicalcium phosphate, croscarmellose
sodium, vegetable magnesium stearate, silicon dioxide,
resin.
EstroG-100® is a registered trademark of Helios Corp.

Directions: Take one tablet daily with food at the sametime of day or as directed by your healthcare
practitioner.
Caution: Do not use if pregnant or nursing. This
product is not recommended for individuals with known
or suspected estrogen-dependent cancer. If taking
medication, consult your healthcare practitioner before
use. Keep out of reach of children.
References:
1. Sherman, S. (2005). Defining the menopausal transition. The American Journal of Medicine,118(12), 3-7.
2. Johnson, A., Roberts, L., & Elkins, G. (2017). Complementary and alternative medicine formenopause. Journal of Evidence-Based Integrative Medicine, 24, 1-14.
3. Santoro, N. (2016). Perimenopause: From research to practice. Journal of Women’s Health,25(4).
4. Gadgil, N. D., & Kulkarni, A. A. (2019). An understanding and comprehensive approach
towards perimenopausal stress: A review. International Ayurveda Publications, 4(1).
5. Sowndhararajan, K., & Kim, S. (2017). Neuroprotective and cognitive enhancement
potentials of Angelica gigas nakai root: A review. Scientia Pharmaceutica, 85(21).
6. Cho, J. H., Kwon, J. E., Cho, Y., Kim, I., Kang, S. C. (2015). Anti-inflammatory effect ofAngelica gigas via heme oxygenase (HO)-1 expression. Nutrients, 7, 4862-4874.
7. Lee, G., Choi, C.-Y., & Jun, W. (2016). Effects of aqueous extracts of Cynanchum wilfordii inrat models for postmenopausal hot flush. Nutrition and Food Science, 21(4), 373-377.
8. Wu, C.-D., Zhang, M., He, M.-T., Gu, M.-F., & Lin, M. (2017). Selection of solvent for
extraction of antioxidant components from Cynanchum auriculatum, Cynanchum bungei,and Cynanchum wilfordii roots. Food Science Nutrition, 7, 1337-1343.
9. Han, S.-H., Lee, T.-H., Jang, J.-Y., Song, H.-K., Hong, S.-K., Kim, Y.-R., & Han, B.-S. (2015).
Mixture of extracts of Cynanchum wilfordii and Phlomis umbrosa does not have an
estrogenic effect in ovariectomized rats. Korean Journal of Food Science and Technology,47(5), 667-672.
10. Lee, J. E., Lee, H., Kim, M. H., & Yang, W. M. (2019). Osteogenic effects of Phlomis umbrosa
via up-regulation of Runx2 in osteoporosis. Biomedical Reports, 10, 17-22.
11. Head, K. A., & Kelly, G. S. (2009). Nutrients and botanicals for treatment of stress: Adrenal
fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Alternative Medicine
Review, 14(2), 114-143.
12. Verma, S. K., & Kumar, A. (2011). Therapeutic uses of Withania somnifera (ashwagandha)
with a note on withanolides and its pharmalogical actions. Asian Journal of Pharmaceuticaland Clinical Research, 4(1).
13. Kittur, S., Wilasrusmee, S., Pedersen, W. A., Mattson, M. P., Straube-West, K., Wilasrusmee,C., Jubelt, B., & Kittur, D. S. (2002). Neurotrophic and neuroprotective effects of milk thistle(Silybum marianum) on neurons in culture. Journal of Molecular Neuroscience, 18.
14. Kim, J.-L., Kim, Y.-H., Kang, M.-K., Gong, J.-H., Han, S.-J., & Kang, Y.-H. (2013).
Antiosteoclastic activity of milk thistle extract after ovariectomy to suppress estrogendefiency-induced osteoporosis. BioMed Research International.

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w These statements have not been evaluated by the Food and Drug

Administration. This product is not intended to diagnose, treat, cure,or prevent any disease.

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