Eugene Consulting Inc.
111 St. Clair Ave W
Toronto, ONM4V 1N5

December/January 2019 ReportuBiome - https://ubiome.com• uBiome is a company that uses machine learning, artificial intelligence, and advanced
statistical techniques to analyze microbes in a user’s body
• Mission: to advance the science of the microbiome and make it useful to people• Customers collect their sample at home using a kit
o Can be done in under 2 minutes
o Simply swipe a swab across the appropriate site and mail the sample back to thelab in an enclosed prepaid envelope• The company then uses their patented precision sequencing methods to analyze thebacteria• Once everything is processed, customers will be send a link to their secure website via
emailo The customer, their healthcare provider is they wish, can then download the test
results• Products offered include: SmartFlu, SmartGut, and Explorer
o SmartFlu – world’s first clinical, sequencing upper respiratory test
▪ Helps patients determine which virus or bacteria is related to theirsymptoms▪ Customers us an easy-to-use nasal microbiome swab and results come in48 hours
o SmartGut - world’s first sequencing-based clinical microbiome test
▪ Provides customers with information on dozens of bacteria to help themand their Healthcare provider manage gut conditions like inflammatory
bowel disease (IBD), including ulcerative colitis and Crohn’s disease,
irritable bowel syndrome (IBS), and even obesity and diabetes▪ Available through healthcare providers
o SmartJane – world’s first sequencing-based clinical microbiome test for vaginal
health▪ Provides genotyping of high-risk HPV, four common STIs (chlamydia,gonorrhea, syphilis, and Micoplasma genitalium), and 23 commensal
bacteria to better understand vaginal health▪ Available through healthcare providers
o Explorer – helps customers track their diet and lifestyles and learn how theirbacteria can help them boost their wellness and stay fit• CLIA-licensed and CAP-accredited laboratory (gold standard for laboratory governance)in San Francisco• Company uses multiple layers of encryption and the highest levels of computer security
to ensure privacy of the users• Clinical tests are HIPAA-compliant

Eugene Consulting Inc.
111 St. Clair Ave W
Toronto, ONM4V 1N5• Research has been approved by an external Institutional Review Board
https://www.fiercebiotech.com/medtech/health-data-firm-sophia-genetics-raises-77m-tosupport-u-s-expansion• Sophia Genetics, the Swiss health data start-up has raised $77M in new venture
capital to support its U.S expansion• The series E round was led by Generation Investment Managementinvestros include:
Idinvest Partners, Balderton Capital, and Alychlo• With this, the company has fundraised a total of $140M
o This funding will also be used to help push its AI-based platform into new
hospital systems• Sophia’s AI program is currently employed by more than 850 hospitals in 77
countries
https://www.ft.com/content/ef9b2226-9981-11e7-a652-cde3f882dd7b• Scientists at the Wellcome Trust Genome Campus are responsible for some of the biggest
genetic discoveries of the past centuryo https://www.wellcomegenomecampus.org
o In the early 1990s, researchers here helped sequence the first human genome• The groundwork laid by the Genome Campus has resulted in an explosion of genomics
software companies worldwide• Companies that can use algorithms to perform smart data analytics and provide diagnoses
have become key targets for investment• Companies that manage the big data will benefit from the discoveries that come from it• Start-ups building clinically useful software and data-mining applications have received awindfall in venture funding• In Europe, investors tend to be more cautious• The challenge of using genomic data for clinical diagnosis has moved from being a
hardware and chemical problem to a data problem• Technological challenges still remain – don't know what cancer looks like that early• The amount of money invested in genomics hit $3.2B in 2017https://www.straitstimes.com/business/companies-markets/trendlines-triples-its-singaporemedtech-start-up-count-in-2018• The Treadlines Group (Isaraeli-based investor) set up 4 medical technology start-ups inSingapore in 2018
o They focus on early-stage medical and agricultural technologies
o They now have 6 start-ups through its wholly owned Trendlines MedicalSingapore subsidiary• New start-ups include
o Medulla Pro Technology, which is developing an imaging system for lumbar
puncture proceduresEugene Consulting Inc.
111 St. Clair Ave W
Toronto, ONM4V 1N5•o AyzerSense technology – tackling the problem of pressure ulcers in patients withtechnology from Ngee Ann Polytechnic
Tredlines Medical Singapore is accredited as a Startup SG Accelerator by government
agency Enterprise Signapore

https://www.healthcaredive.com/news/more-seniors-may-soon-be-sporting-apple-watches-withma-partnerships/546252/• Apple is making a move by talking to 3 private Medicare plans about making Apple
Watches available to seniors to monitor health and fitness• They are looking subsidize the device’s cost so that older patients with a lower/fizedincome can afford it• No deals have been reachedhttps://www.medtechdive.com/news/fitbit-targets-newest-activity-trackers-at-health-wellnessplans/546761/• Fitbit quietly rolled out a new set of fitness trackers for members of health plans and selfinsured organizations
o Fitbit Inspire & Fitbit Inspire HR
o Available solely through the company’s corporate, wellness, health plan, andhealth system partners and affiliated businesses• Fitbit pushes into the health insurance space as Apple is in the talks of subsidizing thecost of Apple Watches• In the fall, Fitbit launched Fitbit Care – a connected health platform for health plans andemployers
o Combines coaching and virtual care with the goal of improving wellness andhelping people manage chronic conditions
o Leverages Fitbit’s wearables technology with the Fitbit Plus app and Twin
Health’s disease management platform▪ Fitbit acquired Twine in February 21018• New to Fitbit Inspireo 24/7 heart rate tracking + real-time heart rate zones
o Real-time heart rate zones
o Sleep stage breakdown
o Variety of exercise modes and GPS-leveraged pace and distance racking• A recent survey by the Healthcare Information and Management Systems Society andFitbit found that ½ of the hospitals and health systems either use or plan to use healthcoaches to connect with patients and facilitate treatment
https://www.darkdaily.com/nebula-genomics-offers-free-whole-genome-sequencing-tocustomers-willing-to-allow-their-data-be-used-by-researchers-for-drug-development/• Nebula Genomics – a start-up genetics company in MassachusettsEugene Consulting Inc.
111 St. Clair Ave W
Toronto, ONM4V 1N5•••••••o Founded by George Church PhD – Harvard Medical School/MIT professor ofgenetics
The company announced they will offer free whole genome sequencing to customers
willing to allow their data to be used by researchers for drug development
Customers answer questions about their health history, physical activities, medications,and more
Researchers them review this information and elect to subsidize the cost of sequencing
specific customers in exchange for access to the resulting genomic data
Customers can also pay $99 for a personal genome sequencing that delivers basic
analysis of their ancestry and inherited traits
Process of selection may begin with a researchers or pharmaceutical firm contacting
Nebula expressing interest in studying a group of patients with a specific disease
Customers can choose how they want their data used and by whom and be compensatedfor itActual genomic data is stored on an Arvados storage platform at Veritas Genetics (acompany also co-founded by Church)