Eugene Consulting Inc.
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June COVID-19 Report
How Quantzig’s big data analytics solutions can help the chemical industry to boost
operational efficiency – April 30, 2020
https://www.businesswire.com/news/home/20200430005345/en/COVID-19-InsightsQuantzig%E2%80%99s-Latest-Success-Story-Reveals- Quantzig is a global data analytics and advisory firm that delivers actionable
analytics solutionso They have offices in the US, UK, Canada, China, and Indiao Firm consists of 120+ clients which includes 55 Fortune 500 companies- Company website: https://www.quantzig.com/services/big-data-analytics- The company conducted a caste study that focused on how coronavirus is impacting
businesses across geographies- The COVID-19 pandemic is bringing about severe budgetary strains in the economy
and companies are being forced to scale down operations to balance the financial
impact of the crisis- Quantzig’s COVID-19 business support solutions can help chemical companies by:o Offering specially curated analytics solutions that focus on ensuring business
continuity to help businesses navigate the crisis
o Offering access to a library of best practices and analytics methodologies that
can help businesses carry out operations smoothly by identifying the COVID19 impact areaso Offering services that involve combinations of components like portal access,ad-hoc/steady projects, and consulting services- In the chemical industry, raw materials prices have started varying and customers;
demands have increased due to the pandemic- Quantzig’s big data analytics solutions can help clients:o Analyze their customers’ preferences and buying patternso Drive profitso Minimize supply chain costso Identify industry trends- Quantzig claims that its advanced analytics platforms ensure complete visibility intobusiness and supply chain operations and thus empowers businesses to enhance
efficiency
o Their advanced analytics platforms are also designed to support the uniqueneeds of clients from different industries- Quantzig’s big data analytics capabilities include:o Sensor data analytics
o Data integration and visualizationo Manufacturing analytics- Their big data analytics can help clients break data silos and unearth valuable
insights to act upon and identify future trends and drive growthEugene Consulting Inc.
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They interface makes it easier to integrate and analyze data from disparate sources,
offering a unified view of organizational data sets
It is predicted that 2020 will bring new challenges such as data complexities, rise incompetition, and stringent regulations to the chemical industry

Predictive analytics models help plan for COVID-19 demands – April 29, 2020
https://healthitanalytics.com/news/predictive-analytics-models-help-plan-for-covid-19demands- With the pandemic, organizations are increasingly turning to real-time analytics
tools to help track and predict healthcare demands- Cleveland Clinic and SAS has created predictive analytics models that help forecast
patient volume, bed capacity, ventilator availability, and other metrics- The predictive models provides timely, reliable information for hospitals and healthsystems to optimize care delivery for COVID-19 and other patients- The analytics models create worst-case, best-case, and most-likely scenarios, unlike
other forecasts that focus on a prediction based on a single set of assumptions- The model adjust in real time
- After reviewing possible COVID-19 surge scenarios generated by the models,Cleveland Clinic prepared for its worst-case scenarioo They built a 1000—bed surge hospital on its education campus for patients
who don't need ICU care
- The models are being share publicly so health systems and government agencies
globally can use themo Models are freely available via GitHub- They hope others will contribute their ideas and improvements to the models- At the center is an epidemiological Susceptible, Exposed, Infected, and Recovered(SEIR) model, developed by Cleveland Clinic and SASo This is based on a University of Pennsylvania open source model that has
been recorded and expanded on the SAS analytics platform and continuously
improved with real-time feedback from Cleveland Clinic epidemiologists- In March, Definitive Healthcare and Esri launched a data platform that allowed users
to analyze and track US hospital bed capacity and potential geographic areas of risk
- Researchers from RAND Corporation also recently released an interactive tool thatallows decisionmakers to estimate current care capacity and explore strategies forincreasing it
o Based off inputs such as baseline number of beds, critical care doctors andnurses, respiratory therapists, and ventilators- Predictive modles and other advanced analytics tools will likely playa critical role inmeasuring and mitigating the impact of the virus through this pandemicEugene Consulting Inc.
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Google’s new coronavirus update: Location data reveals impact on people’s habits inyour area – April 3, 2020
https://www.zdnet.com/article/googles-new-coronavirus-update-location-data-revealsimpact-on-peoples-habits-in-your-area/- Google has released COVID-19 Community Mobility Reports that shows the impact
the coronavirus outbreak has had on travel to work, transit stations, parks, retail
outlets, and grocery stores- This is meant to help public health officials understand how populations are
responding to social distancing- The first report covered 131 countries and regions and included a graph that takes
February 16 as the baseline for normal activity and tracks changes in movements
through to March 29- The charts that show trends over time by geography, across different high-level
categories of places displays trends over several weeks with the most recent
information representing 48-72 hours prioro It is not publishing the absolute number of visits as a privacy measureo- This revealed striking differences between nations in when and how they
implemented lockdowns or began recommending social distancing- In the US, between March 8 and March 29, visits to retail and recreation places had
fallen 47%, parks 19%, and workplaces 38%- In countries such as Italy and Spain, retail and recreation visits were down by 94%
o In Italy, visits to parks also fell 90% and to workplaces, 63%- UK
o Retail and recreation – down 85%- Australia
o Retail and recreation – down 45%- Swedeno Retail and recreation – down 24%
o Parks – up 43%- Norwayo Retail and recreation – down 65%- South Korea – has a strategy for rapid testingo Retail and recreation – down 19%
o Parks – up 51%- Germanyo Retail and recreation – down 77%- India – went int oa sudden 21-day lockdown on March 25
o Retail and recreation – down 77%- As travel restrictions were set to go into place, many places saw a surge in grocery
store visits- There were no reports for China and Iran as Google services are blockedEugene Consulting Inc.
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Google’s mobility reports also show state-level movement trends
They believe that these reports can help shape recommendations on business hours
and inform delivery-service offerings
These reposts are based on data from apps such as Google Maps and devices thathave enabled Location Historyo Technical measures were put in place to ensure that no individual could be
identified through the new reports
Google shared the report a day after EU justice chief Vera Jourova asked techcompanies to share more data with scientists to fight the new coronavirus
They have not shared how frequently they will release the reports
Countries such as China, Singapore, and South Korea have asked residents to use
apps and other technology to track their compliance with quarantineso Privacy activists argue that such measures can compromise individual
liberties
Infectious disease specialists say that analyzing travel across groups using variables
such as age, income, and other demographics could help shape public service
announcements
Google has said that it is not reporting demographic information and has declined tocomment on whether it has received any legal requests to share more detailed datato help with efforts to tackle the pandemic
Facebook Inc, has shared location data with non-governmental researchers that are
producing similar reports for authorities in several countries
o They have not however published any findings
There are concerns surrounding the legality of Google’s processing of location data
and the transparency surrounding that processing
Google also announced that they will be collaborating with epidemiologists working
on COVID-19 with updates to an existing aggregate, anonymized dataset that can beused to better understand and forecast the pandemic

Twitter launches a COVID-19 data set of tweets for approved develops andresearchers – April 29, 2020
- Twitter has made it possible for developers and researchers to study the publicconversation around COVID-19 in real time with an update to its API platform- The company is introducing a new COVID-19 stream endpoint to those participatingin Twitter Developer Labs – a program that offers access to new API endpoints andother features ahead of their public release- The new COVID-19 endpoint will allow approved develops to access COVID-19 andcoronavirus-related tweets across languageso This will result in a data set that will include tens of millions of tweets daily- The data can be used to research a range of topics related to the coronavirus
pandemico Ex. the spread of the disease, the spread of misinformation, crisis
management within communities

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Developers can also use the new data set to build machine learning and data tools
The company will determine which tweets qualify for inclusion in this data set basedon which words are used in the tweets (ex. “COVID-19” or “coronavirus”)
o It will also pull tweets that use common coronavirus hashtags
o They will also filter this data stream to exclude spammy and low-quality
content
Access to the endpoint is free
Twitter will hand-select which developers and researchers will be granted
permission to use it
Developers will have to inform Twitter of their project plan, detail their experiencein working with big data and detail the available resources they have to process sucha data set
They have created a dedicated application to access this endpoint and will carefully
review each request to ensure they support the public goodo In this application, they encourage applicants to describe in detail thesafeguards they intend to implement to protect the privacy and safety ofpeople represented in these datao Developers will also need to have an approved developer account and adhere
to the terms of Twitter’s Developer Agreement and Policy
Apart from this, twitter has also introduced changes on its platform to make COVID19 facts and reliable health information more accessible

Ontario, Canada to build big-data platform to fight coronavirus – April 12, 2002 andJune 4, 2020
https://www.680news.com/2020/04/12/coronavirus-ontario-data-platform-research/https://news.ontario.ca/mohltc/en/2020/06/ontario-appoints-special-advisor-todevelop-health-data-platform.html- The Ontario government plans to create a data platform alled Pandemic Threat
Response (PANTHR) to help in planning for future pandemics
o The system is in the development phaseo Once it is operational, it will securely hold data from publicly fundedadministrative records
o Physician claims, medical drug claims, hospital discharge summaries andclaims for home care and long-term care will be part of the systemo Clinical data from public health, hospital, laboratory and diagnostic imaging
systems will also be included
o the data will be “de-identified” and has been developed in consultation with
Ontario’s Privacy Commissioner- The Ontario government appointed Dr. Jane Philpott as the special advisor to
support the design and implementation of the new Ontario Health Data Platform(formerly known as PANTHR)

Eugene Consulting Inc.
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M4V 1N5-o This will provide recognized researchers and health system partners withaccess to anonymized health data that will allow them to better detect, plan,and respond to COVID-19
o This platform will also support projects from the Ontario COVID-19 Rapid
Research Fund
Researcher will be able to access the platform starting in July 2020
Ontario Health Data Platform website - https://computeontario.ca/covid-19-health/

Tracking coronavirus using big data – April 8, 2002
https://www.ft.com/content/7cfad020-78c4-11ea-9840-1b8019d9a987- Mapping how populations move between locations has proved invaluable in tracking
and responding to epidemicso When the WHO launched an initiative to eliminate malaria in 2007, theyturned to Vodafone, the UK mobile operator, for help
o Vodafone compiled sets of location data from mobile phones in the areas
where cases of the diseases had been recorded- The same type of think has been done to monitor other diseases including Ebola- Thierry Breton, former chief executive of France Telecom and now the European
commissioner for the internal market, has called on operators to share aggregatedlocation data to track how the virus is spreading and to identify spots where help ismost needed- There are questions and hear around how the data might be used once the crisis isover and if these data sets are truly anonymous- In South Korea, authorities can require telecoms companies to hand over the mobile
phone data of people with confirmed infections to track their locationo This has enabled the rapid deployment of a notification system alerting
Koreans to the movements of all potentially contagious people in theirneighborhoods or buildings- China and Israel has also used personal telecoms data to trace coronavirus patientsand their contacts- The EU’s General Data Protection Regulation which was adopted in 2018, also has aclause allowing exceptions for cases that are in the public interest- The use of location to track the disease has been applied in Italy, Spain, Norway andBelgiumo UK, Portugal, and Greece are set to follow- Milan and Madrid telecom operators have created heat maps that show how
restriction on movement are working and what effect the presence of police on thestreets is having on behaviouro This shoed that the movement of people in one city dropped 90% during the
1st week of lockdown in Spain and a further 60% of the remainder in the 2 nd
weeko In Italy, the lockdown was largely ignored for the 1st week and between
800,000 and 1 million people were still travelling in and out of MilanEugene Consulting Inc.
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o In Belgium, citizens were spending 80% of their time within their homepostal area and mobility went down 54%
Telenor, a Norwegian company, has participated in big data projects to predict the
spread of dengue fever in Pakistan and malaria in Bangladesh
Knowledge about a populations’ travel patterns can be vital in understanding how
an epidemic spreads throughout a country
Telefonica, Spain’s national carrier which owns networks across Latin America, hasbeen working with Facebook to use data to deal with natural disasters such as
earthquakes
o They also worked with Unicef and the University of Notre-Dame in 2017 to
improve epidemiological models for predicting the spread of the Zika virus in
Colombia
Vodafone has a researcher paid for by the Bill and Melinda Gates Foundation on its
data team at the London headquarters, to work on data sets providing insights toacademics tracking a variety of diseases
European telecom companies insist that the best way to track the spread of thepandemic is to use heatmaps built on data of multiple phones, when overlaid withmedical data, can help predict how the virus will spread and if government
measures are working
The European Commission wants telecom companies to provide the actual
aggregated data, not just access to insights from that information
A 2019 study by researchers at Imperial College London and Belgium’s Catholic
University of Louvain revealed there is a way to re-identify 99.98 per cent of
individuals with just 15 demographic characteristics using location data
Germany’s Robert Koch Institute has introduced an app, developed with Berlin
digital health group Thryveo It links to fitness bands and smartwatcheso The app will help it map the spread of COVID_19 by monitoring anonymized
data for signs of infection including an users’ resting pulse, sleep and activity
levelso The data drawn from these apps can track individual sufferers and people
they have encountered via contract tracing methods
In Singapore, the government has asked citizens to opt in to its system
The European Commission is working on guidelines on the use of tracing appso Citizens must be able to give informed consent

University of Washington study reports ‘staggering’ death toll in US among those
infected who show symptoms – May 18, 2020
https://www.washington.edu/news/2020/05/18/covid-19-uw-study-reports-staggeringdeath-rate-in-us-among-those-infected-who-show-symptoms/- A new study by the University of Washington published May 7 in the journal Health
Affairs concludes that COVID-19 is more deadly than the seasonal flu

Eugene Consulting Inc.
1602- 111 St. Clair Ave W
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M4V 1N5-o The national rate of death among people infected with the novel coronavirusthat causes COVID-19 and who show symptoms is 1.3%, compared to 0.1%
with the seasonal flu
They also project a grim future if the US does not put up a strong fight against the
spread of the virus
If 20% of the US population becomes infected by the end of the year, number ofdeaths could range from 350,000 and 1.2 million
The School of Pharmacy and Anirban Basu (author of this study) have developed a
website that explores the infection and fatality rates by US counties for people withsymptoms
o Includes data from 116 counties in 33 stateso This is not a forecasting tool but rather a projection of what is currently
happening in these communities

Infection Control Market Projected to be worth $58.2 Billion by 2027 – June 8, 2002
https://www.globenewswire.com/news-release/2020/06/08/2044748/0/en/InfectionControl-Market-Worth-58-2-Billion-by-2027-Pre-and-Post-COVID-19-Market-Analysis-andIndustry-Forecasts-by-Meticulous-Research.html
https://www.meticulousresearch.com/product/infection-control-market-5058/- According to a new market research report “Infection Control Market by Product,and End User- Global Forecast to 2027” published by Meticulous Research®, theinfection control market is expected to grow at a CAGR of 13.3% from 2020 andreach $58.2 billion by 2027
- To prevent and reduce the occurrence rate of infectious diseases, various healthcare
facilities are adopting infection control methods and programs- Nearly 70-80% of hospitals are struggling with shortage of ventilators, masks, otherpersonal protective equipment, hospital beds, and other supplies- Countries with high infection rates are facing huge shortfall for infection control
products- WHO estimates that 89 million medical masks will be required every montho To meet this demand, a 40% increase in manufacturing is expected- They also estimate that frontline workers will need 7-10% of the world’s supply of
surgical masks, and possibly more
- For examination gloves, the figure goes up to 76 million and for goggles, it is 1.6
million per month- Government agencies in these countries are focusing on alternative ways to increase
the production capacityo Examples:▪ As of April 2020, Ralph Lauren Corporation is ramping up productionof 250,000 masks and 25,000 isolation gowns with its US
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The federal government of Canada has encouraged the production of
the PPE domestically in order to produce it at a faster rate
▪ As of April 2020, Lamborghini is helping with production or surgicalmasks and protective shields – producing 1000 masks a day and 200
medical shield a day▪ In April 2020, BMW also entered the mask-making business▪ In March 2020, Retailers Canada Goose Holdings Inc and Gap Inc
announced to begin the production of scrubs and patient gowns f▪ In March 2020, Arkema S.A. (France) has repurposed a production line
at a site in France in order to manufacture 20 tonnes/week of alcoholbased solutions▪ In March 20, 3M Company announced to increase investments, mostly
in the US to boost N95 masks production by 30% over the next 12monthsChina is the world’s largest producer and exporter of maskso Production of masks in normal years accounts for about 50% of the world’s
outputo 70% of which is for export
At present, China’s production of masks has increased more than 10 times to 120
million per dayo Still, the global supply and demand gap of masks cannot be alleviatedChina now makes 200 million face masks a day
Sales of medical masks are up by a staggering 319 percent
The purchase of household maintenance masks is also up by 262% and aerosol
disinfectants by 32%
US medical supplies distributed from the strategic national stockpile (April 2020)
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Due to the pandemic, there is also slowdowns in trade between countrieso This is disrupting the supply chains of many essential commodities – COVID19 testing kits, masks, alcohol-based sanitizers, PPEs, dress materials forfrontline health workers, ventilators for patientsoBased on product type, the cleaning and disinfection products segment is estimatedto account for the largest share of the overall infection control market in 2020
o Rising number of healthcare associated infections due to the unhygienic
surroundings is one of the key reasons for the largest share of this market

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o There is also an increased awareness about cleaning and disinfectant
environment and rising standards for effective cleaning
The endoscope reprocessing products segment is expected to grow at the fastest
growth rate during the forecast yearo Due to the growing importance of diagnostics and therapeutic endoscopy
procedures, concerns regarding surgical wound-associated infections, andtechnological advancement in the medical field
Based on end user, the hospitals and clinics segment is estimated to command thelargest share of the overall infection control market in 2020o Due to the growing incidence of hospital acquired infections and risingnumber of surgical procedureso The increasing chronic diseases associated with aging population, growing
awareness among people for quality care, rising number of hospitalization
due to sudden outbreak of COVID-19, and focus on reducing the healthcareburden caused due to HAIS supported the dominance of this segment
Based on end user, the medical device companies segment is expected to grow at thefastest growth rate during the forecast yearo Due to strict regulations for good manufacturing and packaging practices andcompulsion to follow standard guidelines during manufacturing of medical
devices
North America is estimated to dominate the global infection control market in 2020,
followed by Europe, and Asia Pacifico Growth in North America is attributed to the increasing hospital & outpatient
visits, rising number of surgical procedures, growing number of HAIs,
increasing healthcare expenditure, growth in the pharma & biotech industry,increasing aging population with chronic diseases, and government
initiatives to reduce HAIs & implement effective infection control practices
Asia Pacific region however is expected to grow at the fastest CAGR during theforecast periodo Factors driving the growth of the Asia Pacific infection control market are
accelerated economic growth of many countries, growing government focus
on healthcare sector, rising prevalence of infectious diseases including
COVID-19, and government initiatives for boosting production of infection
control products.
Key operators in this market:
o STERIS plc. (US_o Cantel Meidcal Corp (US)o Gentinge AB (Sweden)o Ecolab (US)o 3M (US)o Advanced Sterilization Products (US)o MMM Group (Germany)o MATACHANA group (Spain)Eugene Consulting Inc.
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M4V 1N5o Belimed (Switzerland)o MELAG Medizintechnik GmbH & Co. KG (Germany)o and more
WHO warns world in ‘new and dangerous phase” of pandemic – June 19, 2020
https://www.ctvnews.ca/health/coronavirus/who-warns-world-in-new-and-dangerousphase-of-pandemic-1.4991762- Scientists warn that while people are growing tired of lockdowns, the diseases
continues to spread with accelerated speed- Italian researchers discovered genetic traces of SARS-CoV-2 in samples of wastewater collected in Milan and Turin at the end of last year and Bologna in Januaryo Yet, their first confirmed cases were not until February- Leaders of European countries held a virtual summit on June 19 on the European
Commission’s proposal for a 750 billion euro rescue fundo However, they fell short of reaching a deal on a plan
- Chinese authorities said that studies of genome data, suggest the new outbreak inBeijing “came from Europe” but is different from what is currently spreading thereo They raised the possibility of the virus lurking in imported frozen food or in
the wholesale market itself, resulting in similarities to older strains
Key model predicts 170,000 US Coronavirus Deaths by October – June 11, 2020
https://www.usnews.com/news/health-news/articles/2020-06-11/us-coronavirusinfections-top-2m-key-model-predicts-170-000-deaths-by-october- The new forecast from the Institute for Health Metrics and Evaluation at the
University of Washington predicts that the coronavirus will kill nearly 170,000
Americans by early October (possible range, 133,201 and 290,222)
o A second wave of the virus is expected in Septembero the forecast used data through June 6
Predicting COVID-19 infection fatality rates around the world – June 16, 2020’
http://www.ipsnews.net/2020/06/predicting-covid-19-infection-fatality-rates-aroundworld/- The epicenter of the pandemic is moving from advanced economies to moredeveloping countries including Brazil, India, and South Africa- Data from Italy show that roughly 96% of COVID-19 fatalities report 1 ore more
relevant comorbidities- The probability of dying from a COVID)19 infection for patients under 40 is roughly
134 times higher with a relevant comorbidity than without- Some developing countries such as South Africa report a considerably higher shareof these conditions among middle-aged people- If fatality rates in developing countries are gauged by drawing a comparison to theinfection fatality rate for another viral respiratory infection such as influenza, as well
as focus on children under the age of 5 to purge variations in age and comorbidities

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that typically begin later in life, this year a COVID-19 infection fatality rate that is
considerably higher than previous estimates for the developing world-

Unlike in the US, the demography and weak health system leads to COVID019 deaths
that are more concentrated among younger people in the developing world
The bulk of deaths in low-and low-middle income countries is predicted to comefrom middle-aged patients (40-70)
When high-quality intensive care is lacking, the advantages of youth are more muted
In Europe data shows that intensive care saves the lives of a higher proportion ofyoung than elderly COVID-19 patientsCoronavirus-Infected Cells Grow Filopodia – June 30, 2020
https://www.the-scientist.com/news-opinion/coronavirus-infected-cells-grow-filopodia67679- A study found that when SARS-CoV-2 infect cultured monkey cells, its co-opts
numerous host proteinso This changes their function through chemical tags known as phosphategroups- A cell protein called CK2 spurs the growth of tentacle-like protrusions known asfilopodia
o These filopodia contain viral particles and are likely used to pole holes innearby cells, spreading SRAS-CoV-2 to themo This may explain rapid viral spread throughout the bodyEugene Consulting Inc.
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40 of the 332 human proteins that interact with SARS-Co-V-2 were significantly
differentially phosphorylated in cells infected with SARS-CoV02
They also identified 49 human kinases out of a total of 518, that showed changes(either upregulation or downregulation) of phosphorylation activity
The most strongly hijacked kinases include casein kinase II (CK2), kinases within
the p38/MAP kinase (p38/MAPK) pathway, cyclin-dependent kinases (CDKs) andphosphatidylinositol 5-kinase (PIKFYVE), all of which fall within a set of cellsignaling pathways
o Because kinases possess certain structural features, they are very druggabletargets with more than 500 compounds commercially available or indevelopment
CK2, a kinase that plays a key role in cytoskeleton formation, cell growth andproliferation as well as apoptosis (cell death), physically interacted with the SARSCoV-2 viral N protein and was significantly more activated in virally infected cells.
o Using a CK2 inhibitor in the laboratory experiments eliminated the virus.
Cells infected with SARS-CoV-2 have significantly reduced CDK activities, which may
facilitate viral replication. I
o Inhibition of CDKs may halt viral replication.
PIKFYVE, a FYVE finger-containing phosphoinositide kinase that regulates
cytoskeleton function, is targeted in a variety of different cancers. The compound
apilimod that targets this kinase potently inhibited SARS-CoV-2 in the laboratory
setting
Based on an initial systematic review of these compounds, the researchers identified
seven agents, primarily anti-cancer and anti-inflammatory compounds, that
demonstrated antiviral activity in laboratory experiments: silmitasertib, gilteritnib,
MAPK13-IN-1, SB203580, ralimetinib, apilimod and dinaciclib.
Interestingly, while studying the impact of SARS-CoV-2 on CK2, high resolution
imaging of virally infected cells revealed actin-rich filopodia containing viralproteinso Human CK2 and the viral N protein were found co-localized within thefilopodia, suggesting that SARS-CoV-2 hijacks CK2 and co-opts it into creatingthese tentacle-like protrusions that poke holes in their neighboring cells
In SARS-CoV-2 infected cells, the filopodia exhibit longer tentacles and branches,enabling more aggressive transmission than some other viral infections.