A technology provider from protein crystallography to in space experiments.

The future is lunar and Mars exploration. Confocal Science is contributing to space exploration by proposing next-generation concepts and technology elements based on its experience in spaceexperiments.

Confocal Science has 30 years of experience in LOE experiments. In particular, the containers made of plastic sheets inthree-dimensional bags are highly reliable, with more than 800
used in more than 25 space experiments.
Left: 3-cell type, right: 6-cell type.
Cells are ﬁlled with solution, loadedwith an inner container ﬁlled withcrystallization sample, andheat-sealed.

Typical inner containerStandard capillary forcounterdiﬀusion
Standard capillary fordialysis method
Large bore capillary

Confocal Science is entrusted with technical support services forspace experiments based on our past experience: services fromplanning and application of space experiments to optimization ofexperimental conditions for space experiments, ﬁlling of samples,
execution of space experiments, collection of samples, and returnof samples to customers.

Based on the experience with space experiments, experimental devices and software that are useful inground-based laboratories are developed.

Two types of the kit, one for X-ray diﬀraction experiment and the other for neutron diﬀraction experiment, are available.
The kit includes a capillary holder, C-Proﬁle, andcrystallization condition optimization software,
which are useful when picking out crystals fromthe capillary with C-Kit Ground Pro.
An active dialysis crystallizer that allows the crystallization solution to be exchanged with a micropump.
The combination of the bag made of gas barriermaterial and oxygen absorber can provide a deoxygenated culture at low cost.

Based on the experiences of thespace experiments, Confocal Science provides a comprehensive
service for protein structure analysis either on a lump-sum basis
or on a process-by-process basis.
Confocal Science provides X-ray diﬀraction data acquisition services using theDiamond Light Source, a synchrotron
radiation facility in the UK.

An interactive service to ﬁnd the best solutions for a customer’scrystallization. Choose from either or both of the services.
After receiving the calculations from C-Proﬁle and some basic
information on the target protein, for a base fee, a crystallization kit with several kinds of optimized crystallization solutions
and instructions will be provided. If a ﬁne crystal grows, thecrystallization conditions will be disclosed with a contingency
fee.
The customer is expected to provide a small amount of theprotein sample under a material transfer agreement. It will beevaluated and the recomendations for the sample preparationand the preferable crystallization method and condition will bereported.

Active learning materials for high school students on the subject of protein crystallization, C-Kit Education to learn sciencescience literacy through protein crystallization in the classroom with the teacher, and C-Kit Space for students to crystallize in the microgravity environment of the International
Space Station (ISS) are provided.

http://www.confsci.co.jp/e-mail : info@confsci.co.jp
Confocal Science Inc.
Musashino Bld. 2F, Fukasawa 5-14-15
Setagaya-ku, Tokyo, 158-0081, JapanTEL 03-5809-1561
FAX 03-6411-6261