Eugene Consulting Inc.
111 St. Clair Ave W
Toronto, ONM4V 1N5

June/July 2019 Report
IQVIA Holdings Inc.
IQVIA is a global provider of information, innovative technology solutions, and contract
research services focused on using data and science to help healthcare clients find better
solutions for their patients• IQVIA helps companies rethink approaches to clinical development andcommercialization, and innovate with confidence• Approximately 61,000 employees in more than 100 countries• IQVIA’s approach to human data science is powered by the IQVIA CORE – seeks out
actionable insights use big data, transformative technology and analytics, and extensive
domain expertise

Vision/goal: to drive healthcare forward and advance human health• Exploring a path to better health outcomes via Human Data Science (big data in health• Providing solutions that help life sciences companies to innovate, maximize
opportunities, and drive human health outcomes forward• Use the power of Human Data Science to identify, understand, and address unmet publichealth needs
o Work in partnership with life science companies, medical researchers, government
agencies, payers, nonprofit organizations, and other healthcare stakeholders →deliver insights and solutions• Use human science expertise and data science together to provide unbiased, fact-based
insights to the healthcare industry

Eugene Consulting Inc.
111 St. Clair Ave W
Toronto, ON
M4V 1N5

Human Data Science and IQVIA• To contribute to the advancement of human health globally, IQVIA created the IQVIA
Institute for Human Data Science to deliver timely research, insightful analysis, andscientific expertise applied to non-identified patient-level datao The Institute delivers objective, relevant insights, and research that support
understanding and innovation that lead to sound decision making and improved
human outcomeso Through collaboration with the Institute, researchers and students have access to abroad range of proprietary databases and tools to support independent research addiscovery
o Partner with academic research organizations to provide data resources andanalysis to further their research• The integration of the study of human science + breakthroughs in data science andtechnology to advance our understanding of human health• We need bigger data and smarter analytics to help us solve specific questions about health• IQVIA is a leader in human data science – they collect, study, de-identify and protect datathat helps us answer questions about human health• IQVIA then helps to link this data to their advanced analytics to answer questions andsolve problems• Human data science can help to diagnose patients, treat their conditions (developtreatments that truly provide the best outcomes) and look for patients earlier and withminimal errors

Leadership
Chairman and CEO – Ari Bousbib

Japan President – Norihiko Minato

Eugene Consulting Inc.
111 St. Clair Ave W
Toronto, ON
M4V 1N5Partnerships and Projects• Drug Safety – IQVIA formed an alliance with the FDA Center for Biologics Evaluation
and Research to assist in the evaluation of safety and effectiveness of various vaccines,
blood products and other biologics
o To do this, worked with the Observational Health Data Science and Informatics
initiative• Fighting the Opioid Epidemic – IQVIA partnered with the American Medical
Association’s Task Force to reduce Opioid Abuse → IQVIA’s data and analyses helped
illustrate the effects of legislation on opioids• Bridging Oncology Gaps – IQVIA created the Collaboration for Oncology Data in
Europe (CODE) with life science partners → CODE is developing an Oncology Data
Network to harness valuable information about anti-cancer medicines• Addressing Antibiotics Resistance – IQVIA collaborated with the U.S. Centers for
Disease Control and Prevention to combat the overuse and misuse of antibiotics
o Information and analysis identified significant regional and local variability inantibiotics use across the U.S.
o Findings shed light on the factors begin the rising number of drug-resistantbacteria strains• As part of the Bill and Melinda Gates Foundation funded effort, IQVIA provided crucial
information about tuberculosis to gain understanding of the true disease burden aroundthe world → worked revealed higher rates of tuberculosis than had been previously
recognized as well as prospective causes• Malaria Access in Action – Collaborated with the Medicines for Malaria Venture toconsolidate data flow and help the Uganda National Drug Authority to develop a system
for monitoring pharmaceutical use at a national level• Enabling Alzheimer’s Insights – IQIA was selected by the European Prevention ofAlzheimer’s Dementia (EPAD) to oversee a longitudinal study of 6000 people that allow
researchers to track the development of Alzheimer’s’ symptoms
IQVIA and Research & Development• With IQVIA CORE, IQVIA helps clients…
o Predict which sites can deliver the right patients → increase enrollment speed up
to 30%o Reduce trial timelines → faster start-up of the right siteso Use real-world data to assess protocol and reduce the risk of protocol changes anddelays
o Use commercial forecasting to evaluate new options to maximize asset valueo Ensure patient safety and data quality through automated, real-time detection ofrisk trends for patients and sites

Eugene Consulting Inc.
111 St. Clair Ave W
Toronto, ON
M4V 1N5IQVIA and Real-World Value and Outcomes• IQVIA helps clients…
o Gather insight and evidence by using real-world datao Enhance collaboration with payers and providers to ensure patients benefit fromthe treatment’s potential
o Use machine learning to drive commercial effectiveness by defining andsupporting differentiation (creating something unique) in a specific therapy area
using machine learning, AI, and clinically rich datao Drive launch excellence and increase sales force effectiveness with advanced
analyticso Plan ahead and reduce risk using AI
IQVIA and Commercialization• IQVIA helps clients…
o Use Human Data Science to seek insights about a market and match it withproven launch excellence strategies, market access plans, and market
development
o Streamline operations to reduce long-term costs and increase efficiency
o Assess the market in real time to allow for fast reactions to market forces andchanges in the market
o Connect with global and local healthcare and functional experts to provide themwith actionable insights and resources to help with product successo Use promotional analysis to help them understand the trajectory of their brand andmeasure its progress along the way
IQVIA Technologies• IVIA Technologies goal is to ensure that clients have the right information at the righttime and in the right place so that every decision they make is the right one• Helps encouraged greater connectivity and collaboration across the enterprise• DrugDev Spark clinical operations suite by IQVIA – allows clients to select ideal sites
based on evidence, implement site feasibility surveys, work with a multilingual team,
IQVIA and Therapeutics• IQVIA is at the forefront of integrating human science expertise with advances inanalytics and technology to help customers ask better questions and extract moremeaningful insights
IQVIA Introduces Patient Centered Endpoints Solution with Transformative eCOA Technology
Platform – June 25, 2019

Eugene Consulting Inc.
111 St. Clair Ave W
Toronto, ONM4V 1N5

https://www.iqvia.com/en/newsroom/2019/06/iqvia-introduces-patient-centered-endpointssolution-with-transformative-ecoa-technology-platform• On June 25, 2019 IQVIA announced the launch of the Patient Centered Endpoints (PCE)
solution – an innovative science and technology-enabled approach that captures evidenceof patients’ experiences during clinical trials and real-world studieso This helps trial sponsors to better understand the patients’ experiences on various
therapies, reduce study implementation timelines, and enhance data transparency• PCE allows life science companies to use real-time direct-from-patient data collections
solutions in their research → by integrating IQVIA’s scientific services with a secure,
electronic clinical outcome assessment (eCOA) on a cloud-based technology platformo eCOA was developed to improve trial experiences for patnets and study teams• PCE is powered by the IQVIA CORE
• PCE solution reflects deep knowledge and understanding of what matters to patients
about their disease and treatment + protects privacy by delivering insights on a nonidentified basis
Chiesi Group Selects IQVIA’s Orchestrated Customer Engagement (OCE) Technology Platform
to Develop a Customer Centric Ecosystem across the Organization – June 17, 2019https://www.iqvia.com/en/newsroom/2019/06/chiesi-group-selects-iqvias-oce-technologyplatform-to-develop-a-customer-centric-ecosystem-across-t• Chiesi Group is now using IQVIA’s OCE technology platform to enhance customer
proximity and teamwork effectiveness in more than 20 marketso They say the OCE platform has the ability to meet the needs of their different
commercial teams and unique customers• IQVIA’s OCE platform is a new category of cloud-based life sciences technology built on
the latest best-in-class platforms like Salesforce and Amazon.
o It has capabilities such as predictive analytics and machine learning, AI-enabled
recommendations, integration with other data and applications to drive betterdecision-makingo It allows companies to move from multiple point applications to a unified
commercial solution that evolves
o Can connect sales, marketing, medical, and other customer-facing functions• Chiesi will create a globally connected commercial ecosystem using OCE Sales, OCE
Marketing, and IQVIA’s OneKey healthcare professionals’ database

IQVIA’s Real World Analytics Capabilities Support Approval of IBRANCE – May 30, 2019https://www.iqvia.com/en/newsroom/2019/05/iqvia-real-world-capabilities-and-expertisesupport-path-to-label-expansion

Eugene Consulting Inc.
111 St. Clair Ave WToronto, ONM4V 1N5•

IQVIA’s real world analytics helped Pfizer Oncology to offer IBRANCE (palbociclib –treatment of adult patients with HR+ and HER2 – advanced or metastatic breast cancer)
for this underserved patient population due to rarity of the disease

IQVIA Launches IQVIA MedTech Dedicated to Medical Device and Diagnostics Industry – May
13, 2019
https://www.iqvia.com/en/newsroom/2019/05/iqvia-launches-iqvia-medtech-dedicated-tomedical-device-and-diagnostics-industry• IQVIA MedTech helps companies with operations of their product from concept-tomarket providing quality control, regulatory safety, and compliance solutions• At this point they had served 800 MedTech clients in more than 70 countries• They help clients develop and execute clinical trials, entering new markets, managing
regulatory processes, addressing global implications of client compliance programs, anddeveloping strategies → support a company’s individual needs• IQVIA MedTech provides information at a geographic scale to drive expansion into
global markets• IQVIA MedTech offers a unique single-course option that integrates well with existingsystems and processes
IQVIA Releases 2019 Medicines Report on U.S. Drug Consumption – May 9 ,2019https://www.iqvia.com/en/newsroom/2019/05/iqvia-institute-for-human-data-science-releases2019-medicines-report-on-us-drug-consumption-us-rx-o• IQVIA released a report that found that prescription opioid dosage volume decline 17%
in 2018 – May 9, 2019
• Other highlights from the report:o There were 5.8 billions prescriptions dispensed in 2018 → up 2.7% from 2017o More then 2/3 of total prescriptions were for chronic conditionso Largest increase in medicine use was seen in anti-hypertensives → mostly driven
by an aging population and expanded guidelines to lower blood pressureo Greater use of 90-day prescriptions and higher adherence rates among patientso Total patient out-of-pockets costs for retail prescription drugs were estimated tobe $61 billion in 2018, $2 billion increased compared with 2017o Total net spending growth on pharmaceuticals is forecast to increase at acompound annual growth rate of 3-6 percent on net price basis → largest driverof this growth will be the launch of new brands