㨬ᚢ⇛ᵴ↪ࡊࡠࠣ࡜ࡓ⺖㗴೑↪ႎ๔ᦠ㨭Ԙታᣉ⺖㗴⇟ภ㧦2005B0960ԙታᣉ⺖㗴ฬ㧦ੑ೷ဳᱤ⏴೷ಣℂߢᱤ⾰ߦᒻᚑߐࠇࠆ CaF2 ࠽ࡁᓸ☸ሶ߅ࠃ߮ᱤ⾰ߩ᭴ㅧ⸃ᨆԚታ㛎⽿છ⠪ᚲዻᯏ㑐෸߮᳁ฬ㧦⧎₺ᩣᑼળ␠ ᭴ㅧ⸃ᨆ࠮ࡦ࠲࡯ ⧯⁜ᱜାԛ૶↪ࡆ࡯ࡓ࡜ࠗࡦ㧦BL19B2Ԝታ㛎⚿ᨐ㧦⎇ⓥ⋡⊛߻ߒᱤࠍലᨐ⊛ߦ੍㒐ߔࠆߚ߼‫ޔ‬%C( ᓸ☸ሶࠍᱤߩ⴫㕙ߦಝ㓸ߐߖࠆᛛⴚࠍᬌ⸛ߒߡ޿ࠆ‫ޕ‬㩖㨹ൻ㩏㩎㩢㨽㩛ߣ㩂㩨㩢㩈㩥㩢㩧㉄㩀㩣㩆㨽㩛 )2%C 㩝㩓㩖㩣㨿㩥㩢㩧㉄㩏㩎㩢㨽㩛㧔/(2㧕ߩ  ೷ಣℂߦࠃࠅ‫ޔ‬㩔㨼㩎㩨㩥㩁㩆㨻㩔㩩㩊㨼㩎㧔*#2㧕☳ᧃ⴫㕙ߦ %C( ࠽ࡁᓸ☸ሶ߇ဋ৻ߦⵍ⌕ߔࠆ੐ࠍ⷗಴ߒߚ‫ޕ‬ᓸ☸ሶߩⵍ⌕ߦࠃࠅ‫ߒ߻ޔ‬ᱤߩ⊒↢ߔࠆ㉄ᕈ᧦ઙਅߢ㩖㨹ൻ‛ߩଏ⛎㊂߇⃻࿷ⴕࠊࠇߡ޿ࠆಣℂߦᲧߴ㜞ߊߥࠅ‫ޔ‬⠴㉄ᕈ߇ะ਄ߔࠆ੐ࠍႎ๔ߒߚ 㧕‫ޔ‬㧕‫ޔ‬㧕‫⎇ᧄޕ‬ⓥߢߪ‫ ޔ‬೷ಣℂߦࠃࠆ %C( ࠽ࡁᓸ☸ሶ↢ᚑᯏ᭴ࠍ᣿ࠄ߆ߦߔࠆ‫࠻ࡅޔߦᦝޕ‬ᱤߦ߅޿ߡ߽ %C( ࠽ࡁᓸ☸ሶߩ↢ᚑߣ‫㉄ޔ‬ᕈ᧦ઙਅߢߩ㩕㩎㨾㩏㩜㩣ߩ᭴ㅧᄌൻࠍ᣿ࠄ߆ߦߔࠆ੐ࠍ⋡⊛ߣߒߚ‫ޕ‬ታ㛎ฦᚑಽࠍ / ฽߻ #$%& ߩ  ⒳㘃ߩṁᶧࠍ⺞⵾ߒߚ‫ޕ‬0C(㧔#㧕‫㉄੃ޔ‬㩀㩣㩆㨽㩛㧔$㧕‫੃ޔ‬㉄㩀㩣㩆㨽㩛㧗/(2㧔%㧕‫ޔ‬㩂㩨㩢㩈㩥㩢㩧㉄㩀㩣㩆㨽㩛㧗/(2㧔& ታ㛎  # ߣฦṁᶧ $㨪& ࠍ╬㊂ߕߟᷙวߒ㧔#$‫ޔ‬#%‫ޔ‬#&㧕‫ ޔ‬ಽ㑆ᡬᜈߒߚ‫ޕ‬ᓧࠄࠇߚᓸ☸ሶࠍ㆙ᔃಽ㔌ߦࠃࠅ࿁෼ߒ㨾㩊㩓㨺㩣ᵞᵺߒ‫⹜ࠍߩ߽ߚߒ῎ੇޔ‬ᢱߣߒߚ‫ޕ‬ታ㛎  ᱤ⾰ࡕ࠺࡞ߣߒߡ *#2 ☳ᧃ㧔⹜⮎㧕ߦ # ߣฦᶧࠍ╬㊂ߕߟᷙวߒ㧔#$‫ޔ‬#%‫ޔ‬#&㧕‫ޔ‬ಽ㑆ᡬᜈಣℂߒߚ‫ࠍᧃ☳ޕ‬ỹ೎ᓟ‫⹜ࠍߩ߽ߚߒ῎ੇޔ‬ᢱߣߒߚ‫ޕ‬ታ㛎  ⹜㛎ᱤ⏴೷㧦0C(㧔೷ 㧕‫ޔ‬㩂㩨㩢㩈㩥㩢㩧㉄㩀㩣㩆㨽㩛/(2㧔೷ 㧕ࠍ฽᦭ߔࠆ  ೷ဳᱤ⏴೷ߣ 0C( ߩߺ㈩วᱤ⏴೷ࠍ⺞⵾ߒߚ‫ޔߢߎߎޕ‬㩖㨹ൻ‛ࠍ㈩วߒߚฦࡍ࡯ࠬ࠻ਛߩ㩖㨹ൻ‛Ớᐲߪ RRO‫ޔ‬ ೷ဳᱤ⏴೷ߩ೷  ߩ㩀㩣㩆㨽㩛㨼㨿㩧Ớᐲߪ RROߦ⺞⵾ߒߚ‫ޕ‬㩕㩎㨾㩏㩜㩣⾰ࡉࡠ࠶ࠢࠍ૞ᚑߒ‫ޔ‬⣕Ἧࠥ࡞㧔/ ੃㉄㧘%C㨙/㧘2㨙/㧘R*㧕ߦߡ ͠ߢ  ᣣ㑆⣕Ἧಣ⟎ߒೋᦼ⯻ᱤࠍᒻᚑߐߖߚ‫ߩߘޕ‬ᓟ‫ޔ‬R* ࠨࠗࠢ࡝ࡦࠣಣ⟎㧔ᱤ⏴೷  ୚Ꮧ㉼ᶧ  ಽ㑆ψ⣕Ἧࠥ࡞  ᤨ㑆ψᱤ⏴೷  ୚Ꮧ㉼ᶧ  ಽ㑆ψࡊ࡜࡯ࠢࡈ࡞ࠗ࠼ࡕ࠺࡞㉄ᕈṁᶧ㧔㧹੃㉄㧘%C㨙/㧘2㨙/㧘R*㧕ONᶐẃ  ᤨ㑆㧕ࠍ⸘  ࿁ⴕߞߚ‫ޕ‬᷹ቯ㧦ࠗࠝࡦࠢࡠࡑ࠻ᴺߦࠃࠅᓸ☸ሶߦๆ⌕ߒߡ޿ࠆ೷ࠍቯ㊂ߒߚ‫ ޕ‬೷ᱤ⏴೷㉄ಣℂᓟߩ㩕㩎㨾㩏㩜㩣ߩ ( ߩሽ࿷ߪ :25 ߢ⸃ᨆߒߚ‫⚿ޔߚ߹ޕ‬᥏᭴ㅧߪ‫ޔ‬$.$ ߦߡ‫ޔ‬㨄✢࿁᛬ᴺ㧔:4&㧕ߦࠃࠅⴕߞߚ‫⹜ޕ‬ᢱࠍ㩁㨶㩕㩩㩡㩢㨺ߦలႯߒ‫ޔ‬㩕㩨㨺㩛㩅㨼㩇㩨 OOOO ᵄ㐳 Έ‫ ޔ‬ಽ㑆᷹ቯߒߚ‫ޕ‬⚿ᨐߣ⠨ኤ㧔ታ㛎 㧕⺞⵾ߒߚᓸ☸ሶߪ :4& ࠃࠅ %C( ߢ޽ࠅ‫ޔ‬#$ ߪ੃㉄‫ޔ‬#% ߢߪ੃㉄ߣ /(2‫ޔ‬#& ߢߪ㩂㩨㩢㩈㩥㩢㩧㉄ߣ /(2 ߇ %C( ߦๆ⌕ߒߡ޿ߚ㧔⴫ 㧕‫ޕ‬:4& ࠃࠅ㩆㨴㩡㨺ᑼ߆ࠄ᳞߼ߚ⚿᥏ሶࠨࠗ࠭ߣฦ೷

− 284 −ߩ %C( ߳ߩๆ⌕㊂ߣߩ㑐ଥࠍߺࠆߣ‫ޔ‬㩂㩨㩢㩈㩥㩢㩧㉄‫ޔ‬/(2 ߩ㩢㩧㉄Ⴎߪ‫ߦ㉄੃ޔ‬Ყߴ %C( ߦᄙߊๆ⌕ߒᓸ☸ሶൻലᨐ߇ᄢ߈޿੐߇ಽ߆ߞߚ‫ޔߪࠇߎޕ‬%C 㩁㩤㨺㩎⢻ߩ㜞޿㩂㩨㩢㩈㩥㩢㩧㉄‫ޔ‬/(2 ߇‫ޔ‬%C( ⚿᥏ᚑ㐳ᛥ೙ߦᒝߊ௛߈‫ޔ‬ᓸ☸ሶൻߔࠆߣ⠨߃ࠄࠇߚ‫ޕ‬㧔ታ㛎 㧕
*#2 ਄ߦ↢ᚑߒߚ☸ሶߪ‫ޔ‬:4& ࠃࠅ %C( ᓸ☸ሶߢ޽ࠅ㧔࿑ C㧕‫ࠢ࡯ࡇޔ‬ಽഀ㧔࿑ D㧕ߦࠃࠅ᳞߼ߚ %C( ߩ⚿᥏ሶࠨࠗ࠭ߪ‫ޔ‬න⁛ߦ↢ᚑߐߖߚ %C( ߣห᭽ߢ޽ࠅ‫ޔ‬㩂㩨㩢㩈㩥㩢㩧㉄‫ޔ‬/(2ߩ㩢㩧㉄Ⴎߪ‫ߦ㉄੃ޔ‬Ყߴᓸ☸ሶൻലᨐ߇ᄢ߈޿੐߇ಽ߆ߞߚ㧔⴫ 㧕‫⚿ߩࠄࠇߎޕ‬ᨐ߆ࠄ‫ޔ‬᳓ṁᕈ㩢㩧㉄ %C Ⴎ߇ %C( ߩ࠽ࡁᓸ☸ሶᒻᚑߦነਈߒ‫ޔ‬ᱤ⾰਄ߦဋ৻ߦ %C( ࠍⵍ⌕ߐߖࠆߣ⠨߃ࠄࠇߚ‫ޕ‬㧔ታ㛎 㧕 ೷ဳᱤ⏴೷㉄ಣℂ‫ ߮ࠃ߅ޔ‬0C( ᱤ⏴೷㉄ಣℂߩ㩕㩎㨾㩏㩜㩣ߦ߅޿ߡ :25 ࠃࠅ ( ర⚛߇⏕⹺ߐࠇߚ‫ޔࠄ߇ߥߒ߆ߒޕ‬:4& ࠃࠅ  ೷ဳᱤ⏴೷㉄ಣℂߩ㩕㩎㨾㩏㩜㩣ߩߺ %C( ࠽ࡁᓸ☸ሶߩᒻᚑ߇⏕⹺ߐࠇߚ㧔࿑ C㧕‫㉄ޔߦᦝޕ‬ಣℂߦࠃࠅ‫ޔ‬%C( ߆ࠄṁ಴ߒߚ ( 㨼㨿㩧ߩ㨾㩏㩜㩣㧔*#2㧕߳ߩଏ⛎ߢ㩖㩣㨿㩥㨻㩔㩩㩊㨼㩎㧔(#2㧕⚿᥏ߩ↢ᚑ߇੍ᗐߐࠇߚ߇⏕⹺ߢ߈ߥ߆ߞߚ㧔࿑ D㧕‫ޔߪࠇߎޕ‬*#2 ⴫㕙ߩߺ߇ (#2 ൻߐࠇ‫(ޔ‬#2*#2 Ყ߇㕖Ᏹߦዊߐ߆ߞߚߚ߼ߣ⠨߃ࠄࠇߚ‫੹ޕ‬ᓟ‫ޔ‬ᱤ⴫㕙ࠍㆬ೎ߒߚ⹜ᢱࠍ⺞⵾ߒ⸃ᨆߒߡ޿ߊ‫ޕ‬ෳ⠨ᢥ₂ ⧯⁜ᱜା‫ޔ‬ਛ⷏㇌ਯ‫ޔ‬ጟᧄ᣽ᐘ‫ޔ‬ጊጯᢕ‫  ╙ޔ‬࿁ࠦࡠࠗ࠼߅ࠃ߮⇇㕙ൻቇ⸛⺰ળⷐᣦ㓸‫ޔ‬  ‫      ޕ‬ ⧯⁜ᱜା‫ޔ‬ਛ⷏㇌ਯ‫ޔ‬ጟᧄ᣽ᐘ‫⾫⍾⌀ޔ‬ᰴ‫ޔ‬ጊጯᢕ‫ޔ‬ဈ↰ቁᄦ‫ޔ‬᫪ඳᄥ㇢‫  ╙ޔ‬࿁ࠦࡠࠗ࠼߅ࠃ߮⇇㕙ൻቇ⸛⺰ળⷐᣦ㓸‫ޕ  ޔ‬ ⧯⁜ᱜା‫ޔ‬ਛ⷏㇌ਯ‫ޔ‬ጟᧄ᣽ᐘ‫⾫⍾⌀ޔ‬ᰴ‫ޔ‬ጊጯᢕ‫ޔ‬ဈ↰ቁᄦ‫ޔ‬᫪ඳᄥ㇢‫  ╙ޔ‬࿁ࠦࡠࠗ࠼߅ࠃ߮⇇㕙ൻቇ⸛⺰ળⷐᣦ㓸‫ޕ  ޔ‬− 285 −Table 1.䇭Properties of CaF2 particles
Adsorption content (m mol/g CaF2)
LactateMFP
Glycerophosphate
0.10
0.05
0.75
0.37
0.55

A-B
A-CA-D1-a㪘㪄㪙㪆㪟㪘㪧㪟㪘㪧㪠㫅㫋㪼㫅㫊㫀㫋㫐㩷㩿㪺㫆㫌㫅㫋㫊㪀㪈㪇㪇㪇㪇㪇㪐㪇㪇㪇㪇㪏㪇㪇㪇㪇㪎㪇㪇㪇㪇㪍㪇㪇㪇㪇㪌㪇㪇㪇㪇㪋㪇㪇㪇㪇㪊㪇㪇㪇㪇㪉㪇㪇㪇㪇㪈㪇㪇㪇㪇㪇㪠㫅㫋㪼㫅㫊㫀㫋㫐㩷䋨㪺㫆㫌㫅㫋㫊䋩SampleCaF2㪈㪇

㪈㪌

㪈㪐㪇㪇㪇
㪈㪎㪇㪇㪇
㪈㪌㪇㪇㪇
㪈㪊㪇㪇㪇
㪈㪈㪇㪇㪇
㪐㪇㪇㪇
㪎㪇㪇㪇
㪌㪇㪇㪇
㪊㪇㪇㪇

1-b㪘㪄㪙
㪘㪄㪚
㪘㪄㪛
㪟㪘㪧

㪈㪎

㪉㪇

Crystallite size (nm)CaF2 / HAP
CaF2
1918
7755㪉㪌
㪉㱔䋨㫦䋩㪈㪏 㪉㱔䋨㫦䋩 㪈㪐㪊㪇

㪉㪇㪊㪌

㪋㪇

Fig. 1 XRD profile of HAP powder treated with the reagents of䋨Ca source+MFP䋩 and NaF.

㪌㪇㪇㪇㪇㪋㪌㪇㪇㪇㪋㪇㪇㪇㪇㪊㪌㪇㪇㪇㪊㪇㪇㪇㪇㪉㪌㪇㪇㪇㪉㪇㪇㪇㪇㪈㪌㪇㪇㪇㪈㪇㪇㪇㪇㪌㪇㪇㪇㪇㪠㫅㫋㪼㫅㫊㫀㫋㫐㩷䋨㪺㫆㫌㫅㫋㫊䋩㪠㫅㫋㪼㫅㫊㫀㫋㫐㩷䋨㪺㫆㫌㫅㫋㫊㪀㪈㪌㪇㪇㪇2-b2-b㪈㪈㪇㪇㪇㪐㪇㪇㪇㪎㪇㪇㪇㪌㪇㪇㪇㪊㪇㪇㪇㪈㪎㪅㪌㪈㪇㪈㪌㪉㪇2-a㪘㪄㪛㪥㪸㪝㪹㫃㪸㫅㫂㪈㪊㪇㪇㪇㪉㪌㪉㱔䋨㫦䋩㪈㪏㪈㪏㪅㪌㪉㱔䋨㫦䋩㪊㪇㪊㪌㪋㪇

Fig. (2-a ) XRD profile of Human enamel powder(A-D; treated with acid solution after with the reagents of 䋨GPCa+MFP䋩+NaF,
NaF; treated with acid solution after with the reagents of NaF,
blank; non treated ).
(2-b) XRD profile of Human enamel powder treated with acid solution afterwith the reagents of 䋨GPCa+MFP䋩 and NaF.

− 286 −