SOLUTIONS FOR

Advancing Neurodegeneration
Therapeutics Discovery

β-Amyloid (1-43) (E8C2D) Rabbit mAb #32098: Confocal IF analysis of brain from an amyloid mouse model of
Alzheimer’s disease using #32098 (green), GFAP #3656 (red), β-Amyloid #42284 (yellow), and DAPI #8961 (blue).

Cathepsin D (E7Z4L) XP® Rabbit mAb #88239: Confocal IF analysis of brain from an amyloid mouse modelof AD using #88239 (green), Iba1/AIF-1 #36618 (red), GFAP #3657 (cyan), and β-Amyloid #35363 (blue).

Solutions That Move Your
Discovery Forward
Put our experience to work for you. Cell Signaling Technology (CST) scientists are biology, application, and therapeuticarea domain experts and are here to streamline your discovery. We are passionate about science and keep up withall the latest neurodegenerative disease research, allowing us to offer a broad antibody portfolio against targets that
could lead to new, more efficacious therapies. CST also offers an extensive post-translational modification-specificantibody portfolio as well as resources like PhosphoSitePlus® PTM Database (www.phosphosite.org).

Table of Contents
4

Cellular Targets in
Therapeutic Development

8

Solutions for Assay
Development

4

Inflammation

8 Multiplex Immunofluorescence (IF) Enablement

4

Cell Death

9 Antibody Pairs for Platforms and ELISA

5

Proteinopathies

5

Cell Viability

6

Metabolism

10 Neuronal Markers

6

Synaptic Plasticity

10 Glial Markers

7

Epigenetics

7

RNA-Binding Proteins (RBPs)

10 Cell Characterization

11 Solutions Across the Drug
Development Continuum
2

For Research Use Only. Not For Use In Diagnostic Procedures.

Tailor CST Products & Services to Fit Your
Project Needs®

Quality & Reproducibility

Reproducibility in your experiments is not a matter of chance. It is a matter of science. CST products
are developed, tested, and rigorously validated across multiple applications by tenured CST scientists
who understand the underlying biology. Over 99.5% of CST recombinant monoclonal antibodies are
manufactured in-house, providing complete control over our supply chain and providing lot-to-lot
consistency for the lifetime of your project.

Assay Support & FlexibilityYour assay is only as good as your antibody is specific. CST antibodies and ready-to-use ELISA andcellular assay kits are developed with this in mind. They are designed to seamlessly fit into your assay
workflow and instantly answer key questions. CST subject matter experts are available to help identify
the best readout and clone to effectively assess your therapeutic efficacy and safety.

Companion Reagents

CST offers a wide selection of epitope-tagged and control antibodies, secondary antibodies, detection
reagents, and experimental controls, as well as standard buffers and other reagents required tocomplete your experimental workflow.

Services & Customization

Sometimes the fastest way to move your discovery forward is to have someone else prepare the tools
you need. CST provides custom solutions that meet your specific research challenges, freeing up yourtime to focus on the science.

Services and Customized Offerings

Overview

Carrier-Free and Customized
Formulations

Ideal for any application, assay, or platform requiring
conjugation-ready or unique formulations, including multiplex
IF and ELISA

Custom Antibody Conjugation

Have our in-house experts perform the conjugations
you need for your assay: fluorophores, biotin, enzymes, selectoligonucleotides, and more

Proteomics Analytical Services

Partner with CST for qualitative and quantitative protein
profiling of your precious samples, including brain tissue. CST
scientists are by your side from project planning to sample
prep to data analysis, providing you with actionable results

Bulk Quantities and Lot Reservation

Eliminate potential supply problems by partnering with
CST to reserve a single lot or place bulk orders

Custom Peptides and Controls

CST provides the controls you need for your specific assay

3

For Research Use Only. Not For Use In Diagnostic Procedures.

Cellular Targets in Therapeutic Development
Inflammation
Chronic neuroinflammation is associated with the progression of neurodegenerative diseases. Microglia are
the resident macrophages of the central nervous system and have key roles in mediating neuronal signaling
and neuroinflammatory responses. CST offers a wide variety of cell signaling markers associated with chronic
neurodegenerative diseases that can be reliably utilized for determining disease onset and progression.

TREM2 Signaling
TREM2 ELISA
Syk/Phospho-Syk ELISADAP12 (TYROBP)Pan Phospho-Tyrosine

Absorbance 450nm

4.0
3.5
3.0

•
•
•
•
•

Jurkat
THP-1

ASC/TMS1
Gasdermin D
NLRP3IL-1β/Cleaved IL-1β
Caspase-1/Cleaved Caspase-1

Cellular Readouts for
Neuroinflammation
•
•
•
•
•

IL-1β/6/10
TNF-α
TGF-β
Stat3
Jak

2.5
2.0
1.5
1.0
0.5
0.0
0.0

0.3

0.6

0.9

1.2

1.5

Events••••Inflammasome

1.8

Protein conc. of lysate (mg/mL)
FastScan™ Total TREM2 ELISA Kit #23831.

ASC/TMS1 (D2W8U) Rabbit mAb (Mouse
Specific) (Alexa Fluor® 647 Conjugate) #23640:
Confocal IF analysis of mouse Tg2576 brainthat overexpresses mutant human APP695
using #23640 (red), GFAP (Alexa Fluor® 555
Conjugate) #3656 (pseudocolor yellow),
β-Amyloid (Alexa Fluor® 488 Conjugate) #51374(green), and DAPI #4083 (blue).

IL-1β
IL-1β (D3U3E) Rabbit mAb #12703: Flowcytometric analysis of THP-1 cells untreated(blue) or treated (red) with LPS #14011 using#12703.

Cell Death
Cell death serves as a readout for neurodegenerative disease progression. Neurons and glia can die and become
diseased due to the aberrant regulation of cell death and survival pathways, which may include mitochondrial dysfunction, autophagy, and the activation of both apoptotic and non-apopototic pathways. With validated antibodies,
protocols, and sampler kits from Cell Signaling Technology (CST), neurodegenerative disease progression can bereliably assessed by analyzing the different types and activation states of cell death in human and rodent samples.

Necroptosis• RIP, Phospho-RIP (Ser166)/(Ser14)• RIP3, Phospho-RIP3 (Ser227)/(Thr231/Ser232)• MLKL, Phospho-MLKL(Ser358)/(Ser345)

Apoptosis• Caspase-3, Cleaved
Caspase-3 (Asp175)• PARP, Cleaved PARP (Asp214)• Caspase-8, Cleaved
Caspase-8 (Asp374)• TUNEL Assay Kits

Pyroptosis• Gasdermin D, Cleaved Gasdermin D (Asp275)/(Asp276)• Cleaved IL-1β (Asp116)/(Asp117)• Caspase-1, Cleaved Caspase-1(Asp297)/(Asp296)

4

For Research Use Only. Not For Use In Diagnostic Procedures.

Proteinopathies
The production and processing of proteins that form protein aggregates are associated with frontotemporal lobar
degeneration and taupathies. Therapies targeting protein aggregate formation may help slow proteinopathy
progression. Protein aggregates found in blood or cerebrospinal fluid may also serve as biomarkers for diagnosing
conditions earlier, and for monitoring disease progression and therapeutic response. Cell Signaling Technology®
(CST®) antibodies are an ideal foundation for biomarker-based assays because they are thoroughly validated forspecificity and sensitivity on biologically relevant binary model systems.

Amyloid••••

Tau/Phospho-Tau

APP
β-Amyloid
β-Amyloid (42/40)
β-Amyloid pyro E• ELISA Kits
• Antibody Sampler Kits
• Conjugates
4.5

Absorbance 450nm

4.0
3.5
3.0

Additional
Neurodegenerative
Aggregate Markers• α-synuclein, Phospho-αsynuclein (Ser129)• TDP43, FUS• Huntingtin

2.5
2.0
1.5
1.0
0.5
0.0

β-Amyloid (D54D2) XP Rabbit mAb #8243:
Confocal IF analysis of the subicular cortex
from an amyloid mouse model of Alzheimer’s
disease mouse using #8243 (green), GFAP
#3670 (red), and DAPI #8961 (blue).

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Cell Viability

PathScan® Phospho-Tau (Thr217) Sandwich
ELISA Kit #59672: #59672 is sensitive enoughto detect differences in Thr217 phosphorylation
among different Alzheimer’s disease patient
samples, which may indicate diseaseprogression.

Huntingtin (D7F7) XP® Rabbit mAb #5656:
IHC analysis of paraffin-embedded mouse
cerebellum using #5656.

Measuring cell viability can serve as a readout for determining neuronal disease progression. Aberrant or reduced
proliferation, increases in neural damage, and the accumulation of senescent cells are all indicators of cell healthand neurodegenerative disease status. CST offers antibodies and assay kits to determine cell viability efficiently
and economically.

Cell Proliferation Markers• BrdU ELISA & Flow Kits
• PCNA• Ki-67

Neural Damage Markers• Neurogranin• Neurofilament-L

Senescence• p16• β-galactosidase
15000

Control
Treated

10000

RFU

Absorbance 450nm

3

2

5000
1
0
0
Mouse
brain

Ki-67 (D3B5) Rabbit mAb #9129: Confocal IF
analysis of the ventricular zone in P21 mousebrain using #9129 (green). Actin filaments
were labeled with DyLight™ 554 phalloidin#13054 (red) and DNA labeled with DRAQ5®
#4084 (blue).

HeLa

Rat brain

PathScan Total Neurofilament-L Sandwich
ELISA Kit #99175: Neurofilament-L protein is
detectable in mouse and rat brain, but not
HeLa cells (negative control) using #99175, as
expected.
®

0.00

0.25

0.50

1.00

Protein onc. of lysate (mg/mL)
Senescence β-Galactosidase Activity Assay
Kit (Fluorescence, Plate-Based) #23833:
β-galactosidase activity in HeLa lysates
untreated and treated with Doxorubicin using#23833.

5

For Research Use Only. Not For Use In Diagnostic Procedures.

Metabolism
The human brain is responsible for about 20% of basal energy expenditure, despite accounting for only 2% of bodyweight. Metabolic dysregulation and neurodegeneration are strongly correlated. Metabolic proteins may act astherapeutic targets since abnormal glucose tolerance or insulin resistance is observed in many neurodegenerative
conditions. Cell Signaling Technology (CST) provides high-quality antibodies and assays to support theinterrogation of metabolic pathways and cellular energy homeostasis regulation.

Metabolite Transporters
•
•
•
•

ABCA1
ABCA7
ApoE4
LRP1

Insulin Receptor
Signaling
•
•
•
•
•
•
•
•

ApoE (E7X2A) Rabbit mAb #49285:
IHC analysis of paraffin-embedded
mouse brain using #49285.

Insulin receptor
Akt
CREB/Phospho-CREB
Glycogen Synthase/PhosphoGlycogen Synthase
GSK-3β/Phospho-GSK-3β
PI3K
PTEN
PDK1

Autophagy
•
•
•
•

mTOR
AMPK
LC3B
ULK1/Phospho-ULK1(Ser757)/(Ser555)• SQSTM1/p62• TFEB/Phospho-TFEB (Ser211)

Mitophagy• Pink1• Parkin/Phospho-Parkin(Ser65)• DRP1• Ubiquitin/Phospho-Ubiquitin(Ser65)• TBK1/Phospho-TBK1 (Ser172)• Optineurin/PhosphoOptineurin (Ser177)• FUNDC1• BNIP3/3L

Synaptic Plasticity
Synaptic plasticity is not only a part of development, learning, and memory, but has also been utilized as a readout
for the clinical diagnosis of neurodegenerative diseases, including synaptopathies like Alzheimer’s disease. CST
provides high-quality antibodies and assays to support the interrogation of synaptic activity and function.

Presynaptic Proteins• Synaptophysin• Synapsin-1/PhosphoSynapsin-1

Synaptophysin (D8F6H) XP® Rabbit mAb#36406: Confocal IF analysis of mouse brain
using #36406 (green), Neurofilament-L #2835(yellow), Lamin A/C (4C11) Mouse #4777 (red),and DAPI #8961 (blue).

Postsynaptic Proteins• PSD95/Phospho-PSD95• AMPA Receptor 1 (GluA1)/
Phospho-AMPAR 1 (GluA1)• NMDAR-1/Phospho-NMDAR-1

PSD95 (D27E11) XP® Rabbit mAb #3450:
Confocal IF analysis of rat cerebellum using#3450 (red), Neurofilament-L #2835 (green),
DRAQ5® #4084 (pseudocolor blue).

Modulators of Synaptic
Plasticity• CaMKII• Calcium Signaling• CREB/Phospho-CREB

CaMKII-α (6G9) Mouse mAb #50049:
Confocal IF analysis of primary neurons using
CaMKII-α #50049 (green) and DRAQ5® #4084(pseudocolor blue).

6

For Research Use Only. Not For Use In Diagnostic Procedures.

Epigenetics
Brain health is heavily reliant on epigenetic mechanisms, and a loss of chromatin dynamics is observed in neurodegenerative diseases. Profiling epigenetic patterns and identifying the chromatin marks associated with diseaseprogression have become increasingly important for the development of therapies against neurodegeneration.
Cell Signaling Technology (CST) provides a comprehensive and diverse catalog of epigenetics products and an
extensive assay portfolio used to measure protein-DNA interactions and histone modifications.

Histone Modifications
Acetyl-Histone H4 (Lys16)
HDAC2/6
p300
SirT1
REST, CoREST
G9a/EHMT2
LSD1

•
•
•
•

5-mC, 5-hmC
DNMT1
TET1
MeCP2

Immediate Early Genes
and Associated Proteins• CREB/Phospho-CREB• c-Fos/Phospho-c-Fos• EGR1
Phospho-c-Fos (Ser32) (D82C12)
XP® Rabbit mAb #5348

Signal relative to input

•
•
•
•
•
•
•

DNA Methylation

MeCP2 (D4F3) XP® Rabbit mAb #3456:
Confocal IF analysis of SH-SY5Y cells using#3456 (green) and actin (red).

0.018
0.016
0.014
0.012

Normal Rabbit IgG #2729

0.010
0.008
0.006
0.004
0.002
0

CCRN4L

DCLK1

GAPDH

Phospho-c-Fos (Ser32) (D82C12) XP® Rabbit
mAb #5348: qRT-PCR results for ChIP-enriched
DNA from PC-12 cells starved overnight andtreated with hβ-NGF #5221 and either #5348
or Normal Rabbit IgG #2729 using SimpleChIP®
Enzymatic Chromatin IP Kit (Magnetic Beads)#9003

RNA-Binding Proteins (RBPs)
RBPs are increasingly becoming therapeutic targets for the treatment of neurodegeneration. Dysregulation ofRNA-binding proteins (RBPs) has been linked to amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, and frontotemporal dementia. Mutations in stress granule-associated RBPs lead to the pathological accumulation of protein aggregates that are readily apparent in neurodegenerative disorders. Age-related changes in mRNA methylation and methylation-dependent RBPs have also been associated with neurodegeneration. CST offers antibodies
against key RBPs, stress granules, and m6A methylators, validated in relevant neuronal systems.

RBPs and Stress
Granules•••••

TDP43, FUS
TIA-1, TIAR
FMRP
G3BP1
Ataxin-1/2

RNA m6A
Methylation

TDP43 (D9R3L) Rabbit mAb (Alexa
Fluor® 555 Conjugate) #68779:
Confocal IF analysis of mouse
cerebellum using #68779 (red), Ras(Alexa Fluor® 647 Conjugate) #37182(cyan pseudocolor), and DAPI #8961(blue).

•••••

N6-Methyladenosine
METTL3/14
FTO
ALKBH5YTHDF1/2/3
YTHDF2 (E2I2H) Rabbit mAb#71283: Confocal IF analysis ofmouse medulla oblongata using#71283 (red), GFAP (Alexa Fluor® 488
Conjugate) #3655 (green), and DAPI
#8961 (blue).

7

For Research Use Only. Not For Use In Diagnostic Procedures.

Solutions for Assay Development
Multiplex Immunofluorescence (IF) Enablement
Cell Signaling Technology (CST) has the breadth of products available to enable several methods of multiplex
staining, highlighted below.

Host Species• One of the simplest ways to multiplex• Use primary antibodies derived fromvarious host species and isotypes(rabbit IgG, mouse IgG1, rat IgG2a, etc.),
then probe with fluorophore-coupledsecondaries specific to the host primary.

Confocal IF analysis of mouse Tg2576 brain labeled with GFAP #34001 (green), β-Amyloid #15126 (red), HS1 #3892 (magenta), and DAPI #8961 (blue).

Fluorophore Conjugated Antibodies• Directly conjugate a primary antibody witha specific label, such as a fluorophore or
enzyme• CST offers rigorously validated, readyto-use antibodies conjugated to the mostpopular fluorophores.

Confocal IF analysis of an amyloid mouse model of Alzheimer’s disease brain using Alexa Fluor® 647 Conjugated Iba1/AIF-1 #78060 (red), Alexa Fluor® 488 Conjugated
HS1 #68206 (green), GPNMB #90205 (yellow), and methoxy XO4 (blue). Image kindly provided by Dr. Simone Briochi of Dr. Marco Colonna’s lab (Washington University)and used with permission.

Conjugation-Ready Carrier-Free
Antibodies• Preferred method when expanding panels
or using technologies where a directly
conjugated antibody is not available.
• Use carrier-free formulated antibodies.
They are conjugation-ready to support
platforms requiring labels such as metals,
fluorophores, and oligonucleotides.
Multiplex IF imaging of the human prefrontal cortex from an Alzheimer’s disease patient stained with GFAP (blue), microglia with Iba-1/AIF-1 #17198 (cyan), ApoE
#13366 (green), and β-Amyloid #9888 (red). Imaged with the Akoya PhenoCycler® platform. Image kindly provided by Akoya and used with permission.

8

For Research Use Only. Not For Use In Diagnostic Procedures.

Antibody Pairs for Platforms and ELISA
Rigorously validated antibody pairs are at the heart of every ELISA experiment. Cell Signaling Technology(CST) offers matched antibody pairs, both as a complete solution in sandwich ELISA kits or as custom pairs,
ideal for incorporating into standard high-throughput ELISA-like assay platforms. These validated antibody
pairs offer unrivaled specificity to deliver accurate readouts when monitoring therapeutic modulation of key
neurodegenerative disease biomarkers. Some CST kits are sensitive to plasma proteins, enabling monitoring of
disease status with live models.

Measure Key Biomarkers with Highly Specific and Sensitive ELISA Kits
3.500
3.000

Absorbance 450nM

2.500
2.000
1.500

1.000
0.500
0.000
Aβ-42 ELISA Kit Competitor A
500 pg/ml

CST Aβ-42 ELISA kit #27029
2.0 pg/ml
Aβ-37

Aβ-38

Aβ-39

Aβ-40

Aβ-42 ELISA Kit Competitor B
400pg/ml
Aβ-42

Aβ-43

Aβ-pE3Aβ-42 ELISA Kit Competitor C
100 pg/ml
Blank

The PathScan® β-Amyloid (1-42) Sandwich ELISA Kit #27029 is highly specific to only human Aβ-42, showing no
significant signal with Aβ-37, Aβ-38, Aβ-39, Aβ-40, Aβ-43, or pE3 peptides, as expected. By contrast, other leading
commercially available β-amyloid (1-42) sandwich ELISA kits show little-to-no specificity towards the advertised
Aβ-42 target.

Absorbance 450nm

0.6

0.4

The FastScan™ Phospho-Tau (Thr181) ELISA Kit #58537
detects human tau in plasma from the hTau P301S mousemodel in as little as 50 µL of plasma.

0.2

Data kindly provided by Dr. Li-Huei Tsai (Massachusetts Institute of Technology) andused with permission.

0.0
WT

Tau P301S9For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Characterization
Neuronal Markers
Studying the brain and nervous system requires examination not only of neurons, but also of microglia, oligodendrocytes, and astrocytes. The key to visualizing and identifying each of these cell types lies in using antibodies thattarget protein biomarkers specifically expressed and localized within these cells. Cell Signaling Technology (CST)
provides highly specific, validated antibodies against accepted neuronal markers.

Immature
Neuronal Markers••••

Mature NeuronalMarkers

Doublecortin
NeuroD1TBR1
β3-Tubulin
Doublecortin (A8L1U) Rabbit mAb#14802: Confocal IF analysis of P5mouse cerebellum using #14802(green), GFAP #3670 (red), andDRAQ5® #4084 (psuedocolor blue).

• MAP2• NeuN• NeurofilamentH/L/M• Neuron Specific
Enolase (NSE)• Tau• Thy1• β3-Tubulin

Glial Markers• UCHL1

NeuN (D4G4O) XP® Rabbit mAb#24307: Confocal IF analysis ofmouse hippocampus using #24307(green) and actin labeled with
DyLight™ 554 Phalloidin #13054(red). DRAQ5® #4084 (pseudocolor

Glial cells consist of the non-neuronal supporting cells, including astrocytes, oligodendrocytes, and microglia.
Distinct changes in glial cells and their markers are known to be associated with neurodegenerative diseaseprogression. Glial cells also play an important role in overcoming challenges with the blood-brain barrier. CST has
a wide variety of validated glial marker antibodies to identify and study the different glial cell types.

Astrocytes
•
•
•
•
•

GFAP
S100B
ALDH1L1
AQP4
EAAT1/2

S100B (E7C3A) Rabbit mAb#90393: Confocal IF analysis
of fixed frozen mouse cerebral
cortex. #90393 (red), HS1 (Alexa
Fluor® 488 Conjugate) #68206(green), and DAPI #8961 (blue).

Oligodendrocytes
•
•
•
•
•

MBP
MOG
Olig2
CNPasePLP1

Olig2 (E6G6Q) XP® Rabbit mAb#65915: Confocal IF analysis of
fixed frozen mouse cerebellum.
#65915 (red), GFAP (Alexa Fluor®
488 Conjugate) #3655 (green),
and DAPI #4083 (blue).

Microglia
•
•
•
•
•

DAM Markers

Iba1
CD11b
CD45
F4/80
CD68

•
•
•
•
•
•
•
•

Iba1/AIF-1 (E4O4W) XP® Rabbit
mAb #17198: Confocal IF analysis
of mouse CA1 hippocampus using#17198 (green) and DAPI (blue).
Images kindly provided by Dr.
Marco Colonna (Washington
University) and used withpermission.

ApoE
DAP12 (TYROBP)
TREM2
GPNMB
TMEM119
Axl
CD11c (ITGAX)/33
Galectin-3

TMEM119 (E3E1O) Rabbit mAb#90840: Confocal IF analysis of an
amyloid mouse model of Alzheimer’s
disease brain using #90840 (green),
GFAP #3670 (yellow), β-Amyloid (Alexa
Fluor® 647 Conjugate) #42284 (red),and DAPI #8961 (blue).

10

For Research Use Only. Not For Use In Diagnostic Procedures.

Solutions Across the Drug Development Continuum
Industry-Leading and Aligned to Your Workflow
Target ID and
Valdiation

Screening andLead Optimization

Target ID and MOA Studies• Proteomic Services leveraging
MS technology

Identifying Primary andSecondary Endpoints• ELISA, HCS, Multiplex IHC

Target Validation

Platform Compatibility• Western Blot
• IHC and Multiplex IHC• Flow Cytometry• ELISA: MSD, AlphaLISA, HTRF,
Quanterix• Multiplex IHC: Akoya,
Hyperion, Nanostring• Automated WB (e.g.
ProteinSimple)

Flexible Packaging• Lot Reservation• Bulk Quantities

Preclincial Safety
and Validation
Industry-Leading IHCValidation for BioMarker
Identification and Detection
Ready-to-Use ELISA Kits to Key
Readouts and Translational
Biomarkers
IHC Autostainer Compatible

Custom• Matched antibody pairs (ELISA)• Antibody conjugation services• 96- to 384-well ELISA kit

Antibodies That Work on Your Platform
Platforms

Application

Conjugate Type*• TR-FRET/LANCE/HTRF• AlphaLISA/Screen• MSD• Quanterix (Simoa)• Luminex• High Throughput ELISA• Fluorophores• Lanthanides• Biotin• Beads• CyTOF/Helios• Hyperion• MIBI• Flow Cytometry• Mass Cytometry/IMC• Multiplex IHC• Metal Ions

• Akoya• Nanostring• 10 Genomics (Visium)• Leica (Cell DIVE)• Multiplex IHC• Oligonucleotides• Fluorophores• IHC Autostainers

• IHC

• N/A

• High Content Screening& Analysis• IF Imaging• Fluorophores• ProteinSimple• Simple Western• N/A*Some conjugates directly available for purchase from CST (other conjugate types may be proprietary)

Product Format• BSA- and Azide-Free
Formulation• Matched Antibody Pairs• Optimized
Concentration• BSA- and Azide-Free
Formulation• Optimized
Concentration• Antibodies validated
in house for Simple
Western****Growing list of select antibodies

11

For Research Use Only. Not For Use In Diagnostic Procedures.

Local Sales Representative

Cell Signaling Technology (CST®) is a different kindof life sciences company—one founded, owned, andrun by active research scientists, with the highest
standards of product and service quality, technologicalinnovation, and scientific rigor for over 20 years.
We consistently provide fellow scientists around theglobe with best-in-class products and services tofuel their quests for discovery. CST is a company ofcaring people driven by a devotion to facilitating goodscience—a company committed to doing the right thingfor our Customers, our communities, and our planet.

www.cellsignal.com
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CST antibodies are guaranteed to work – first time, every time
To learn more, please visit: www.cellsignal.com/abguarantee© 2022 Cell Signaling Technology, Inc. Cell Signaling Technology, CST, and XP are trademarks of
Cell Signaling Technology, Inc. All other trademarks are the property of their respective owners.
Visit cellsignal.com/trademarks for more information.
21-BPA-52151-OCT22 For Research Use Only. Not For Use in Diagnostic Procedures.