SyncroPatch 384
For all your patch clamp needs

SyncroPatch 384

Unprecedented flexibility for HTS
automated patch clamp
The SyncroPatch 384 is a revolutionary automatedWith its ease-of-use and open design, thepatch clamp system combining high quality

SyncroPatch 384 is much more than a fully

electrophysiological data acquisition and analysis

automated HTS system. It can be efficiently

with state-of-the-art liquid handling.

used for lower throughput applications.

With 384 amplifier channels and a 384-pipetting

The SyncroPatch 384 is ideally suited for academic

head, up to 384 cells can be recorded in parallel,

research labs, CROs and industrial research

resulting in a throughput of up to 20,000 high-because of its unprecedented flexibility, including

quality data points per day.

32-well mode, unattended mode, advanced
temperature control, stacked compound addition
and the use of fluoride-free solutions.

SyncroPatch 384

Key features at a glance1

384 recordings in parallel

5

32-well mode for smaller projects

2

Giga-seal recordings

6

Single- or multi-hole chips

3

Up to 20,000 data points per day

7

Up to 95 % success rate

4

Advanced temperature control

8

Voltage and current clamp as standard

SyncroPatch 384

Efficient data handlingand export
PatchControl 384 is a powerful graphical user

DataControl 384 accelerates data analysis byinterface for intuitive, quick and easy setup ofquick and easy loading of recorded files and user

voltage protocols and experimental parameters.

defined analysis templates.

• Intuitive, quick and easy-to-use setup ofexperiments• Analysis performed with a few mouse clicks(IC50, EC50, Z’ values, Vhalf etc.)• Broad range of QC options• Data analysis templates display results within
seconds• Color-coding of recording wells basedon set QC parameters• Instant re-calculation upon parameter changes• Raw data and analysis results viewed in thesame window• Heat maps for intuitive overview of compound
effects• Standard and advanced operation• Customized data export• Word, Excel, csv and pdf reporting

DataControl 384
Scroll through the data, select a data
analysis template or fit parameters.
Results, compound information and QC
parameters are exported in a userdefined export format, ready for further
database integrations.

SyncroPatch 384

For all your patch clamp needs
Choose your throughput

Advanced temperature control

The 32-well mode transforms the SyncroPatch 384

An advanced temperature control system allows

into a lower throughput device, enabling bothprecise control of the temperature (10–37 °C) atlarger and smaller screens in one instrument, andthe measurement site and at 12 deck positions.

making the most out of the low price per data point.
• Recordings at physiological temperature• Use parts of the chip—in multiples of 32 wells• Use remaining chip over several days with noreduction in success rate

• Temperature-controlled module, solutions andcell hotel• Cooling and heating• Perfect for assay development, biophysicalstudies and smaller screening projects

Up to 20,000 dp/day326496384

SyncroPatch 384

Your research, our passion

Ion channels

Assay development and validation

Ideal for both voltage- and ligand-gated ion

Full flexibility to design assays for a wide variety ofchannels.

cell lines.

Drug Discovery

CiPA validation study

Suitable for all phases of drug discovery inThe SyncroPatch 384 is delivered fully compliant

pharma and biotech.

with the latest CiPA recommended guidelines.

Academic research

Channelopathies

Easy solutions tailored to ensure your next

Sophisticated functional assays for the discovery

scientific breakthroughs.

of ion channel mutations.

CROs

Primary cell/iPSC profiling

Deliver accurate, reproducible and high quality

Low cell consumption for recording primary anddata on time and within budget.

stem cells.

SyncroPatch 384

The SyncroPatch 384 includes• Biomek i5 liquid handler with a 384-pipettor arm and gripper• Windows 10 OS with PatchControl 384 and DataControl 384 software suite• Temperature-controlled patch clamp module and deck positions• NPC-384 borosilicate recording chips• 384 channel amplifier incl. current clamp• Guided Labware Setup and Method Launcher• 1 year warranty with further optional comprehensive service plans available• Unmatched technical and application support

Specifications
Average whole-cell stability>30 minutes

Successful whole-cell recordings

Up to 95 %Throughput

20,000 data points per day

Seal resistance>1 GΩ

Series resistance<10 MΩ

Chip resistance~3 MΩ (different ranges available)

Perfusion time constant<50 msMinimum exposure time

<1 s

Liquid handling robot

Biomek i5 (Beckman Coulter)

Amplifier channels

384

Number of pipettes

384

Temperature control

10 – 37 °C (integrated as standard)

Current clamp

Integrated as standard

accelerate your researchnanion Europe
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www.nanion.denanion USA
info@naniontech.com
phone: 1-888-9-NANION
www.naniontech.com
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phone: +86 10 82 17 6388
www.nanion.cn
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phone: +81 3 6457 8773
www.nanion.jp

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representative, visit our website:www.nanion.de