FUNGICIDE

Pyriofenone
Selective fungicide for Powdery mildew
Pyriofenone is a selective Powdery mildew fungicide discovered anddeveloped by ISK.
Pyriofenone has a unique mode of action, which disrupts actin function(FRAC code 50). Thanks to this MOA, Pyriofenone strongly inhibits
conidia formation to prevent secondary infection and halts all steps ofthe infection process including hyphal growth and appressoria formation.
Pyriofenone has excellent rainfastness and residual activity and also
controls Powdery mildew through vapor action and translaminar
movement.
Pyriofenone has outstanding crop safety with little to no impact on
beneficial organisms making it an excellent choice as a rotation productfor your spray program.

Physico-Chemical Properties
Chemical structure

Toxicology & Ecotoxicology
O

CH3

Rat LD50 (oral) : > 2,000 mg/kg (m/f)
Rat LD50 (dermal) : > 2,000 mg/kg (m/f)
Rat LC50 (inhalation) : > 5.18 mg/L (m/f)

CH3

ClNO

O

CH3

CH3

OO

CH3

Skin irritation : non irritant (rabbit)
Eye irritation : non irritant (rabbit)
Skin sensitization : sensitizing to skin (guinea pig, Buehler test)
negative (LLNA test)

CH3

Class : Aryl-phenyl-ketones
IUPAC name : (5-chloro-2-methoxy-4-methyl-3-pyridyl)(4,5,6-trimethoxy-o-tolyl)methanone
Molecular weight : 365.8
Molecular formula : C18H20ClNO5Vapour pressure : 1.9 x 10-6 Pa (25°C)
Water solubility : 1.56 mg/L (20°C)
Form : White Solid (Powder)
Development code : IKF-309

Avian LD50 (acute oral) : > 2,000 mg/kg (quail, m/f)
Avian LD50 (subacute oral) : > 5,000 ppm in feed (quail)
Fish LC50 : > 1.36 mg/L (carp, 96 h)
Bees LD50 (acute oral) : > 100 μg a.i./bee (48 h)
Bees LD50 (acute contact) : > 100 μg a.i./bee (48 h)
Daphnia magna EC50 : > 1.96 mg/L (48 h)

Product
Trade Names

PROPERTY, PROLIVO, KUSABI, UNCICUT, etc.

Formulations

30%SC, 18%SC

Registered Countries

Asia

Japan, Korea, etc.

EuropeAustria, Belgium, Bulgaria, Croatia, Czech Republic, Denmark, France, Finland, Germany,Greece, Hungary, Italy, Lithuania, Luxembourg, Netherlands, Poland, Portugal, Romania,Slovenia, Spain, Sweden, UK, etc.

Oceania

Australia, New Zealand

Americas

Canada, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Peru, USA, etc.

Always read and follow the product label instructions in your country.

Characteristics
・Specialized in Powdery mildew control

・Decreases secondary infections by inhibiting conidia formation

・Unique mode of action (FRAC code 50)

・Excellent rainfastness and residual activity

・Inhibits disease at every step of the infection process・Outstanding crop safety with little or no impact on beneficial organisms

・Good vapor action

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154

Pyriofenone

FUNGICIDE

Selective fungicide for Powdery mildew

Mode of Action
Subcellular localization of actin at hyphal apex is necessary for polar growth of hypha. Vesicles carrying thematerial for hyphal growth are transported toward localized actin. It is hypothesized that the mode of action of
Pyriofenone is the induction of mislocalization of actin from the apex, resulting in disrupted apical transport,
induced swelling, collapse and abnormal branching of hyphal tips.
Observation of actin on hyphaltips by Fluorescence microscopeActinlocalization

Cell wall/membranesynthesis at apex

Mycelial growth

Actin Vesicle
Microtubule

Untreated control

Untreated control

Hyphal apex

Sufficient strength
at apex

Abnormal branch

Growth at apex

Collapsed hyphal tips

Peripheral zone

Pyriofenone treatedInsufficient synthesis
and induced swelling

Burst

Pyriofenone treatedVapor action

Registered Crops

Pyriofenone moves into the gaseous phase and re-distributes locally. This vapor action allows Pyriofenone
to mitigate gaps in spray coverage and control Powdery mildew on nearby untreated plant tissue.

AppleGreen Pepper

Asian Pear

TomatoPyriofenone
treatedMango

Spinach BeetPersimmon

Podded Pea

Water
treated

Grape

Cucurbits

Strawberry

Ornamentals

Untreated

Berries

Cereals

Pyriofenone treatedEggplant

The bunches were treated with
Pyriofenone or water, inoculatedwith conidia of Erysiphe necator,and evaluated. Bunches wereincubated in paper bags until
disease symptoms presented(shown in picture).
Untreated (Vapor Phase)etc.

Always read and follow the productlabel instructions in your country.

Untreated

Cucumber trials (Field trial and Sensitivity test for different MOA fungicides)
Cucumber field trial against Powdery mildew*

Isolate sensitivity test to fungicides with different MOA**

MIC (ppm)

Untreated control

Pyriofenone

QoIDMI

Isolate 1

0.4>100

10Isolate 2

0.4>100

1

Pyriofenone+DMI A
75+75 g a.i./ha
DMI A 75 g a.i./haPyriofenone
75 g a.i./ha0204060

Disease severity (%)

80

100

Pyriofenone shows no cross resistancewith different MOA fungicides.

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

MIC (minimum inhibitory concentration)
values were evaluated on
Podosphaera sp.-infected leaf disks
floating on solutions containing
each fungicide at concentrations
ranging from 0.05 to 100 ppm.
Trials were conducted by ISK*Field trial (2014) **Sensitivity test (2013)

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154