HERBICIDE

Tolpyralate
Selective corn herbicide
Tolpyralate is a HPPDi (Hydroxyphenyl Pyruvate Dioxygenase
Inhibitor, HRAC Group 27) herbicide discovered by ISK.
Tolpyralate controls a wide range of broadleaf weeds andannual grasses and has excellent safety on all types of corn.
Tolpyralate is also effective against weeds resistant to othermodes of action including glyphosate and ALS inhibitors.
Tolpyralate is a powerful tool for your fields.

Physico-Chemical Properties

Toxicology & Ecotoxicology
O

Chemical structureONONOSOO

Rat LD50 (oral) : > 2,000 mg/kg (f)Rat LD50 (dermal) : > 2,000 mg/kg (m/f)
Rat LC50 (inhalation) : > 2.01 mg/L (m/f)

O

Skin irritation : non irritant (rabbit)
Eye irritation : GHS Not classified (rabbit)
Skin sensitization : not a sensitizer (guinea pig)

OO

Class : Pyrazole
IUPAC name : (RS)-1-{1-ethyl-4-[4-mesyl-3-(2-methoxyethoxy)-o-toluoyl]-1H-pyrazol-5-yloxy}ethyl methylcarbonate
Molecular weight : 484.52
Molecular formula : C21H28N2O9S
Vapour pressure : 5.9×10-4 Pa (25 ˚C)Water solubility : 26.5 mg/L (20 ˚C)Form : Off-white solid
Development code : SL-573

Application

Avian LD50 (acute oral) : > 2,000 mg/kg (quail, m/f)
Avian LD50 (subacute oral) : > 5,000 ppm in feed (quail)
Fish LC50 : > 22 mg/L (carp, 96 h)
Bees LD50 (acute oral) : > 107.7 μg a.i./bee (48 h)
Bees LD50 (acute contact) : > 100 μg a.i./bee (48 h)
Daphnia magna EC50 : > 22 mg/L (48 h)Mode of Action

Use
Post-emergence application of Tolpyralate
controls a wide range of broadleaf weeds
and grass weeds. Tolpyralate helps you tofight problematic weeds in your corn fieldwith low use rates of 30-50* g a.i./ha .
*Appropriate dose rate is defined to fit your location
and weed species. Follow the label instructions in yourcountry.

What happens after application?
Tolpyralate is rapidly absorbed by leaf and stem tissue and works by disrupting an essentialfunction in the plants physiology. Once absorbed by the plant Tolpyralate blocks the productionof the HPPD (4-hydroxyphenylpyruvate dioxygenase) enzyme. This inhibits the plants ability toproduce plastoquinone and alpha-tocopherol compounds. Without these compounds theformation of carotenoid pigments is interrupted causing the destruction of chlorophyll by sunlight,
which is lethal to susceptible weeds. While complete weed death can take up to two weeks,
once treated the weeds no longer compete with the growing corn.
Selectivity
Corn plants can rapidly break down Tolpyralate into non-toxic substances, therefore it has
excellent crop safety for all types of corn.

ProductTrade Names

BRUCIA, SHIELDEX, RAKER, RAKER PRO etc.

Formulations

40%SC, 10%OD etc.

Registered Countries

Asia

Japan, Korea, PhilippinesAmericas

Argentina, Canada, Chile, Mexico, USA

Always read and follow the product label instructions in your country.

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154

Tolpyralate

HERBICIDE

Selective corn herbicide

Characteristics
・HRAC Group 27
・Mode of action: Inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD) enzyme・Excellent safety for all types of corn (field corn, sweet corn, popcorn, seed corn)
・Controls a wide range of broadleaf weeds and annual grass weeds including difficult control weeds, such as Amaranthus spp, Setaria spp.
・Low-use formulation with application rates between 30 to 50 g a.i./ha.
・Effective for weeds resistant to other herbicide modes of actions including glyphosate and ALS inhibitors, including Amaranthus tuberculatus,
Ambrosia trifida and Erigeron canadensis.
・Excellent tank-mix partner with other commonly used herbicides such as chloroacetamides, glyphosate, glufosinate, atrazine, dicamba.

Visual Effect of Herbicidal Activity -Tolpyralate Treated Corn Field-

14 days after application

28 days after application

Weed Spectrum
Weed Spectrum

Grass weeds

FamilyCommon Name

Digitaria sanguinalis

Large crabgrass

Echinochloa crus-galli

Barnyardgrass

Eleusine indica

Goosegrass

Setaria faberi

Giant foxtail

Setaria pumila

Yellow foxtail

Setaria viridis

Green foxtail

Amaranthus palmeri

Palmer amaranthAmaranthus tuberculatus

Waterhemp

Bassia scoparia

KochiaChenopodium albumCommon lambsquarters

Ambrosia artemisiifolia

Common ragweed

Ambrosia trifida

Giant ragweed

Erigeron canadensis

Horseweed

Brassicaceae

Raphanus sativus

Wild radish

Caryophyllaceae

Stellaria media

Common chickweed

Lamiaceae

Lamium amplexicaule

HenbitMalvaceae

Abutilon theophrasti

Velvetleaf

Molluginaceae

Mollugo verticillata

Carpetweed

Polygonaceae

Polygonum aviculare

Prostrate knotweed

Solanaceae

Solanum nigrum

Black nightshade

PoaceaeAmaranthaceae

Broadleaf weeds

Scientific Name

Asteraceae

Setaria faberi

Digitaria sanguinalis

Ambrosia trifida

Chenopodium album
and more

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154