HERBICIDENICOSULFURON
Selective systemic herbicide
Nicosulfuron is a sulfonylurea herbicide which was originallydiscovered by ISK. It controls a wide range of weeds coveringboth annual and perennial species.
Because of its excellent performance, Nicosulfuron has beenused by corn growers globally since it was launched in theearly 1990’s.

Physico-Chemical Properties
Chemical structure

Toxicology & Ecotoxicology
OCH3

N

Rat LD50 (oral) : > 5,000 mg/kg (m/f)
Rat LD50 (dermal) : > 2,000 mg/kg (m/f)
Rat LC50 (inhalation) : 5.47 mg/L (4 h)

NSO2NHCONH
NCON(CH3)2

Skin irritation : non irritant (rabbit)
Eye irritation : non irritant (rabbit)
Skin sensitization : not a sensitizer (guinea pig)

OCH3

Class : sulfonylurea
IUPAC name : 2-(4,6-dimethoxypyrimidin-2-ylcarbamoyl
sulfamoyl)-N, N-dimethylnicotinamide
Molecular weight : 410.4
Molecular formula : C15H18N6O6S
Vapour pressure : <8×10-7 mPa (25°C)
Water solubility : 7.5 g/L (20°C, pH 6.5°C)
Form : White solid, no characteristic odour
Development code : SL-950

ApplicationAvian LD50 (acute oral) : > 2,000 mg/kg (quail, m/f)
Avian LD50 (acute oral) : > 2,000 mg/kg (mallard duck, m/f)
Fish LC50 : 65.7 mg/L (trout, 96 h)
Fish LC50 : > 100 mg/L (bluegill, 96 h)
Bees LD50 (contact) : 76 μg/bee
Bees LD50 (oral) : > 22.4 μg/beeDaphnia magna EC50 : 90 mg/L (48 h)Mode of Action

Uses Nicosulfuron controls annual grass
weeds, broad leaved weeds, and perennial
weeds such as Sorghum halepense andElymus repens at rates of 30–60 g a.i./ha.

Plant Uptake Nicosulfuron is rapidly absorbed by leaf tissue and is translocated meristems via
the phloem and xylem. Nicosulfuron controls weeds by inhibiting acetolactate synthase (ALS),
also called acetohydroxy acid synthase (AHAS). ALS is a necessary enzyme for the production of
three branched-chain amino acids, isoleucine, leucine, and valine.

Phytotoxicity Nicosulfuron has excellent
selectivity to corn. In cases where corn isstressed, nicosulfuron may cause yellowingof corn foliage; however, it is transient anddoes not affect yield.

Symptoms Weeds treated with nicosulfuron will first begin to develop chlorosis in the newgrowth and then gradually, as the weed continues to be starved of the vital branched-chainamino acids, the chlorosis symptomology will develop in older growth. Chlorotic symptomology
then turns to necrosis and desiccation of the plant tissue occurs. Control typically takes 3-4weeks, from treatment to plant death.
Selectivity Nicosulfuron’s excellent selectivity to corn is due to the ability of corn to metabolize
nicosulfuron into inactive metabolites.

ProductTrade Names

MOTIVEL, NISSHIN, FORNET, SAMSON, SANSON, NICO, 玉农乐, ワンホープ, etc.

Formulations

6%OD, 4%SC

Registered Countries

Asia

Japan, China, Korea, Thailand

EuropePortugal, Spain, Belgium, Czech, France, Greece, Netherland, Poland, Slovakia, Ukraine, Bulgaria,Romania, Croatia, Germany,Hungary, Serbia, Slovenia, Austria, etc.

AmericasUSA, Brazil, Argentina, etc.

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154

NICOSULFURONHERBICIDE

Selective systemic herbicide

Visual Effect of Herbicidal Activity

Characterisitics
ALS inhibitor
Excellent activity at low dosages(30–60 g a.i./ha)Broad weed spectrum including
grasses, broadleaf weeds andsedges
Safe to corn
Safe to birds, fish, bees and otherbeneficial insects

Untreated

Nicosulfuron Treated Plot
(30 days after application)

Weed Spectrum
Weed Spectrum

SedgesBroadleaved weeds

Grass weeds

Scientific Name

Common Name

Rate (g a.i./ha)
Leaf Stage

30–40

45–60

Digitaria sanguinalis

Large crabgrass

6++++++

Setaria viridisGreen foxtail

6+++

+++

Eleusine indica

Goosegrass

6++

+++

Avena fatua

Wild oat

3+++

+++

Echinochloa crus-galli

Barnyard grass

3+++

+++

Sorghum halepense

Johnson grass

6++

+++

Elymus repens

Quackgrass

4++

+++

Galinsoga quadriradiata

Shaggy soldier

4++

+++

Stellaria media

Common chickweed

4++

+++

Polygonum lapathifolium

Pale smartweed

3++

+++

Chenopodium album

Lamb’s quarters

2+++

Sida spinosa

Prickly side2++

Abutilon theophrasti

Velvetleaf

1++

Senna tora

Sickle senna

1++

Amaranthus viridis

Slender amaranth

2+++

+++

Solanum nigrum

Black nightshade

4++

Portulaca oleracea

Common Purslane

3++

+++

Commelina communis

Asiatic dayflower

2++

+++

Capsella bursa-pastoris

Shepherd’s purse

4++

+++

Cynodon dactylon

Asian flatsedge

3+++

+++

Cyperus rotundus

Purple nutsedge

5+

+++

+++: Excellent control,++: Good to fair control,+: Poor control

Application: Post-emergence of weeds (applied at leaf-stage described in the table)

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154