FUNGICIDECYAZOFAMID
Selective Oomycete fungicide
Cyazofamid is a selective Oomycete fungicide discovered and developed –on a global basis – by ISK. After the first launch in 2001, ISK has started its
commercialization in various crops in many countries.
Cyazofamid, with its unique mode of action, is highly effective against
Oomycete diseases. Cyazofamid also has good persistence and offers
excellent rain fastness in many crops at low rates.
Cyazofamid has no negative impact on beneficial insects and mites, and thus,
it will be surely added to integrated pest management programs.
Cyazofamid has good toxicological, environmental and ecotoxicological profiles.

Physico-Chemical Properties
Chemical structure

Toxicology & Ecotoxicology

H3C

Rat LD50 (oral) : > 5,000 mg/kg (m/f)
Rat LD50 (dermal) : > 2,000 mg/kg (m/f)
Rat LC50 (inhalation) : > 5.5 mg/L (4h) (m/f)

SO2N(CH3)2N
CNCI

Skin irritation : slight irritant (rabbit)
Eye irritation : slight irritant (rabbit)
Skin sensitization : not a sensitizer (guinea pig)

NClass : cyanoimidazole
IUPAC name : 4-chloro-2-cyano-N,N-dimethyl-5-ptolylimidazole-1-sulfonamide
Molecular weight : 324.8
Molecular formula : C13H13ClN4O2S
Vapour pressure : < 1.33x10-2 mPa (35°C)
Water solubility : 0.107 mg/L(pH 7, 20°C)
Form : Ivory, odourless powder
Development code : IKF-916

Avian LD50 (acute oral) : > 2,000 mg/kg (quail, m/f)
Avian LD50 (acute oral) : > 2,000 mg/kg (mallard duck, m/f)
Fish LC50 : > 100 mg/L (trout, 96 h)
Fish LC50 : > 69.6 mg/L (carp, 96 h)
Bees (oral and contact) : very low toxicity
Daphnia magna EC50 : > 0.198 mg/L (48 h)

Application

Mode of Action

Cyazofamid is applied at 80-100 g a.i./ha with foliar spray just before
first disease symptoms are observed to control Oomycete diseases,
such as late blight in potatoes, tomatoes, pepper and other vegetables,and downy mildew in grapevine, cucumber, melon and others.

Cyazofamid has proven to control Oomycetes by respiratory inhibition
specifically at ComplexⅢ in the mitochondria of Oomycetes.
Cyazofamid inhibits Qi (Quinone inside reducing site) of ComplexⅢ ofthe said oomycetes, which has not been so far reported for otherfungicides. It is classified to FRAC code 21.

Product
Trade Names

RANMAN TOP, RANMAN, SEGWAY, TORRENT, ランマン, 科佳, MILDICUT, VIDERYO, ドーシャス,グリーンワーク, etc.

Formulations

16%SC, 10%SC, 40%SC, 27.5%SC (Premixture), 44%SC (Premixture), 29%WP (Premixture)

Registered Countries

Asia

China, Japan, South Korea, Taiwan, Vietnam, etc.

EuropeAustria, Belgium, Denmark, France, Germany, Italy, Netherlands, Poland, Portugal, Romania,Serbia, Spain, Sweden, Switzerland, UK, etc.

AmericasArgentina, Brazil, Canada, Chile, Mexico, USA, etc.

Oceania

Australia, New Zealand

Crops

Potatoes, Grapes, Vegetables, Turf, etc.

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154

CYAZOFAMIDFUNGICIDE

Selective Oomycetes fungicide

Biological mode of action

Characterisitics

Zoosporemotility

ZoosporereleaseCystospore
Germination

Cyazofamid inhibition

Zoosporangia
formation

Mycelial
growth

Oosporeformation

Inhibition of Zoospore formation ontomato leaves

Inhibits all stages in fungus life cycle (in vitro)
Low fungi application rate: 80-100 g a.i./ha or 50-100
ppm conc
Effective on fungi resistant to other chemical classes
Strong control activity against potato tuber blight
Strong rainfastness
Distribution on newly developing leaves
Inhibition of zoospore formation on leaves
No phytotoxicity concerns
No adverse effects on yeast or microbial activity offermentation system
Very active against the following Oomycetes:• Phytophthora• Pseudoperonospora• Plasmopara• Albugo• Blemia

Distribution on newly
developing potato leaves
Cyazofamid amount
LowHigh

Newly developing
leavesTreated leaves

0 day after
application

Cyazofamid 100ppm

7 days after
application

Untreated control

Control of Potato Late Blightby long spray interval period

Control of Potato Tuber Blight

Cyazofamid
100ppm10days95

Cyazofamid
80g a.i./ha

10.5

Fungicide A
1280g a.i./haCyazofamid
100ppm14days86

Fungicide A
1850ppm
7days

Fungicide B
1020+1020g a.i./ha60

65

70

75 80 85
Control Value (%)

57.6

Fungicide C
1508+
192g a.i./ha75

036.9

90

95

10024.1

0ISHIHARA SANGYO KAISHA, LTD.

10203040
Rotten tuber (%)

506070

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154