眞 岡 孝 至 論 文 目 録
Original（原著）査読あり
1) 松野隆男、永田誠一、勝山政明、松高寿子、眞岡孝至、秋田俊子、魚類のカロテノイドに関する比較生化学的研究 - XVIII. 養殖イワナ、カワマス、レークトラウト、ヤマメ、アマゴ、ニジマス、ブラウントラウトについて、 日本水産学会誌、46, 473-478 (1980).
2) 松野隆男、眞岡孝至、坂口茂樹、魚類より -caroten-2-ol の分離、日本水産学会誌、46,
1527-1531 (1980).
3) Takao Matsuno, Takashi Maoka and Katsuyuki Hiraoka, A new acetylenic carotenoid from sea
mussels, Bull. Jap. Soc. Sci. Fish., 47, 143 (1981).
4) 松野隆男、眞 岡孝至、イ ガイより新 カロテノイ ド 3,4,3'-trihydroxy-7',8'-didehydro-carotene の分離, 日本水産学会誌、47, 377-384 (1981).
5) 松野隆男、平岡勝行、眞岡孝至、ホタテガイ卵巣のカロテノイド, 日本水産学会誌、47､385-390 (1981).
6) 松野隆男、眞岡孝至、アカガイおよび近縁二枚貝３種より Diatoxanthin, pectenoxanthin,pectenolone および新カロテノイド 3,4,3'-trihydroxy-7',8'-didehydro--caroteneの分離、日本水産学会誌、47, 495-499 (1981).
7) 松野隆男、平岡勝行、眞岡孝至、二枚貝よりえられた新カロテノイド 3,4,3'-trihydroxy7',8'-didehydro--caroteneの合成的証明、 日本水産学会誌、47, 501-505 (1981).
8) Takao Matsuno and Takashi Maoka, Identity of tunaxanthin A with oxyxanthin 45, Bull. Jap. Soc.
Sci. Fish., 49, 1299 (1983).
9) Takao Matsuno, Takashi Maoka, Kiyoshi Katagiri and Tadaaki Komori, A new carotenoid,
isorenieradicistene from the sea sponge Suberites sericeus , Bull. Jap. Soc. Sci. Fish., 50, 1071-1075(1984).
10) Takao Matsuno, Takashi Maoka and Masaaki Katsuyama, The identity of tunaxanthin A and(3R,6S,3'R,6'S)-, -carotene-3,3'-diol (oxyxanthin 58), Bull. Jap. Soc. Sci. Fish., 50, 1445 (1984).
11) Takao Matsuno, Takashi Maoka, Shigeki Sakaguchi and Tokuzi Nishizawa, Absoluteconfiguration of pectenol, Bull. Jap. Soc. Sci. Fish., 50, 1251-1253 (1984).
12) Takao Matsuno, Kiyoshi Katagiri, Takashi Maoka and Tadaaki Komori, Carotenoids of thespindle shell Fushinus perplexus, Bull. Jap. Soc. Sci. Fish., 50, 1583-1588 (1984).
13) Takao Matsuno, Takashi Maoka, Masaaki Katsuyama, Masahiro Ookubo, Kiyoshi Katagiri and
Hajime Jimura, The occurrences of enantiomeric and meso-astaxanthin in aquatic animals, Bull. Jap.
Soc. Sci. Fish., 50, 1589-1592 (1984).
14) Takao Matsuno, Masaaki Katsuyama and Takashi Maoka, Isolation of lactucaxanthin fromtilapia Tilapia nilotica, Bull. Jap. Soc. Sci. Fish., 50, 1735-1737 (1984).
15) Takao Matsuno, Masaaki Katsuyama, Takashi Maoka, Toshihiko Hirono and Tadaaki Komori,
Reductive metabolic pathways of carotenoids in fish (3S,3'S)-astaxanthin to tunaxanthin A, B and C,

1

Comp. Biochem. Physiol., 80B, 779-789 (1985).
16) Takao Matsuno, Kiyoshi Katagiri, Takashi Maoka and Tadaaki Komori, Novel reductive
metabolic pathways of 4-oxo--end group in carotenoids of the spindle shell Fushinus perplexus,
Comp. Biochem. Physiol., 81B, 905-908 (1985).
17) Takashi Maoka, Tadaaki Komori and Takao Matsuno, Direct diastereomeric resolution of
carotenoids I. 3-Hydroxy-4-oxo--end group, J. Chromatography, 318, 122-124 (1985).
18) Yoshihiro Ikuno, Takashi Maoka, Minoru Shimizu, Tadaaki Komori and Takao Matsuno, Direct
diastereomeric resolution of carotenoids II. All ten stereo isomers of tunaxanthin (,-carotene-3,3'diol), J. Chromatography, 328, 387-391 (1985).
19) Takashi Maoka and Takao Matsuno, The first isolation and identification of tunaxanthin D[(3S,6R,3'R,6'S)-, -carotene-3,3'-diol] from marine fishes, Bull. Jap. Soc. Sci. Fish., 51, 1349-1351(1985).
20) Takashi Maoka, Masaaki Katsuyama, Nobuyuki Kaneko and Takao Matsuno, Stereochemical
investigation of carotenoids in the antarctic krill Euphausia superba, Bull. Jap. Soc. Sci. Fish., 51,
1671-1673 (1985).
21) Takao Matsuno, Shigeki Sakaguchi, Masahiro Ookubo, and Takashi Maoka, Isolation andidentification of amarouciaxanthin A from the bivalve Paphia euglypta (Sudaregai in Japanese),
Bull. Jap. Soc. Sci. Fish., 51, 1909 (1985).
22) Yoshihiro Ikuno, Minoru Shimizu, Yasuyo Koshino, Takashi Maoka and Takao Matsuno,
Stereochemical investigation of carotenoids from yellow-tail rock fish Sebastes flavidus, Bull. Jap.
Soc. Sci. Fish., 51, 2033-2035 (1985).
23) Takao Matsuno, Masaaki Katsuyama, Toshihiko Hirono, Takashi Maoka and Tadaaki Komori,The carotenoids of tilapia Tilapia nilotica, Bull. Jap. Soc. Sci. Fish., 52, 115-119 (1986).
24) Takao Matsuno, Takashi Maoka, Keiko Shiba and Masahiro Ookubo, Isolation of fucoxanthinol
from short-necked clam Tapes philippinarum [Asari in Japanese], Bull. Jap. Soc. Sci. Fish., 52, 167(1986).
25) Takashi Maoka, Naoko Masuda, Yoshihiro Ikuno and Takao Matsuno, The first isolation andidentification of tunaxanthin G and tunaxanthin H from carp Cyprinus carpio, Bull. Jap. Soc. Sci.
Fish., 52, 357 (1986).
26) Takao Matsuno, Takashi Maoka and Yoshihiro Ikuno, Comparative biochemical studies ofcarotenoids in fish XXVII, Carotenoids in the eggs of three species of Cyprinidae, Comp. Biochem.
Physiol., 83B, 335-337 (1986).
27) Takashi Maoka, Akihiro Arai, Minoru Shimizu and Takao Matsuno, The first isolation ofenantiomeric and meso-zeaxanthin in nature, Comp. Biochem. Physiol., 83B, 121-124 (1986).
28) Kiyoshi Katagiri, Takashi Maoka and Tahao Matsuno, Carotenoids of shellfishes VIII.
Comparative biochemical studies of carotenoids in three species of spindle shell, Fushinus
perplexus, F. perplexus ferrugineus and F. forceps, Comp. Biochem. Physiol., 84B, 473-476 (1986).
29) Takao Matsuno, Toshihiko Hirono, Yoshihiro Ikuno, Takashi Maoka, Minoru Shimizu andTadaaki Komori, Isolation of three new carotenoids and proposed metabolic pathways of carotenoids
in hen's egg yolk, Comp. Biochem. Physiol., 84B, 477-481 (1986).

230) Takao Matsuno, Takashi Maoka, Masaaki Katsuyama, Toshihiko Hirono, Yoshihiro Ikuno,
Minoru Shimizu and Tadaaki Komori, Comparative biochemical studies of carotenoids in fishes XXIX Isolation of new luteins, lutein F and lutein G from marine fishes, Comp. Biochem. Physiol.,
85B, 77-80 (1986).
31) Takao Matsuno, Yasuko Tani, Takashi Maoka, Kenji Matsuo and Tadaaki Komori, Isolation andstructural elucidation of cucurubitaxanthin A and B from pumpkin Cucurbita maxima,
Phytochemistry, 25, 2837-2840 (1986).
32) Kiyoshi Katagiri, Yasuyo Koshino, Takashi Maoka and Takao Matsuno, Occurrence of
pirardixanthin derivatives in the prawn, Penaeus japonicus, Comp. Biochem. Physiol., 87B, 161-163(1987).
33) Takao Matsuno and Takashi Maoka, The carotenoids of crab Paralithodes brevipes(Hanasakigani in Japanese), Nippon Suisan Gakkaishi, 54, 1437-1442 (1988).
34) Takashi Maoka and Takao Matsuno, Isolation and structural elucidation of three new acetyleniccarotenoids from the Japanese sea mussel Mytilus coruscus, Nippon Suisan Gakkaishi, 54, 14431447 (1988).
35) Takashi Maoka and Takao Matsuno, Metabolism of carotenoids in terrestrial snail Euhadra
callizona amaliae, Comp. Biochem. Physiol., 92B, 41-43 (1989).
36) Takashi Maoka, Sachiko Yokoi and Takao Matsuno, Comparative biochemical studies ofcarotenoids in nine species of Cephalopoda, Comp. Biochem. Physiol., 92B, 247-250 (1989).
37) Miyuki Tsushima, Takashi Maoka and Takao Matsuno, Comparative biochemical studies ofcarotenoids on marine invertebrates. The first positive identification of ,-carotene derivatives andisolation of two new carotenoids from chitons, Comp. Biochem. Physiol., 93B, 665-671 (1989).
38) Takashi Maoka, Miyuki Tsushima and Takao Matsuno, New acetylenic carotenoids from thestarfishes Asterina pectinifera and Asterias amurensis, Comp. Biochem. Physiol., 93B, 829-834(1989).
39) Takashi Maoka and Takao Matsuno, Diastereomeric resolution of carotenoids III. , -caroten2-ol, , -carotene-2,2'-diol and 2-hydroxyechinenone, J. Chromatography, 478, 379-386 (1989).
40) Takashi Maoka and Takao Matsuno, Diastereomeric resolution of carotenoids IV. Carotenoids
with a 4-hydroxy--end group, J. Chromatography, 482, 189-195 (1989).
41) Takao Matsuno, Takashi Maoka and Yutaka Toriiminami, Carotenoids in the Japanese stick
insect Neophirosea japonica, Comp. Biochem. Physiol., 95B, 583-587 (1990).
42) Takao Matsuno, Tetsuo Watanabe, Takashi Maoka and Yoshiko Takemura, Carotenoids ofcrustacea - VII. Carotenoids in the sea louse Ligiaexotica (Crustacea:Isopoda), Comp. Biochem.
Physiol., 95B, 759-761 (1990).
43) Yasuhiro Fujiwara, Takashi Maoka, Masahiro Ookubo and Takao Matsuno, Crassostreaxanthin
A and B, Novel marine carotenoids from the oyster Crassostrea gigas, Tetrahedron Lett, 33, 49414944 (1992).
44) Miyuki Tsushima, Takashi Maoka, Masaaki Katsuyama, Mutsuo Kozuka, Takao Matsuno,
Harukuni Tokuda, Hoyoku Nishino and Akio Iwashima, Inhibitory effect of natural carotenoids on3

Epstein-Barr virus activation activity of a tumor promoter in Raji cells. A screening study for antitumor promoters, Biol. Pharm. Bull., 18, 227-233 (1995).
45) Akiyo Sakushima, Maksut Coskun and Takashi Maoka, Hydroxybenzoic acids from Boreava
orientalis, Phytochemistry, 40, 257-261 (1995).
46) Akiyo Sakushima, Makust Coskun and Takashi Maoka, Sinapinyl But-3-enylglucosinolate from
Boreava orientalis, Phytochemistry, 40, 483-485 (1995).
47) Kazuko Ida, Kazumori Masamoto, Takashi Maoka, Yasuhiro Fujiwara, Satomi Takeda andEmiko Hasegawa. The leaves of the common box, Buxus semperivirens (Buxaceae), Become red as
the level of a red carotenoid, anhydroeschscholtzxanthin, increase, J. Plant Res., 108, 369-376(1995).
48) Keiji Hashimoto, Tsutomu Yaoi, Hiroyuki Koshiba, Tomoyuki Yoshida, Takashi Maoka,
Yasuhiro Fujiwara, Yasuo Yamamoto and Kazuo Mori, Photochemical isomerization of piperine, apungent constituent in pepper, Food Sci, Technol. Int., 2, 24-29 (1996).
49) 眞岡孝至、伊藤義博、藤原靖弘、橋本圭二, 日本産イチイ (Taxus cuspidata) 果実のレトロタイプカロテノイドの構造と酸化防止作用, 日本油化学会誌, 45, 641-646 (1996).
50) Takashi Maoka and Yasuhiro Fujiwara, Absolute configuration of mytiloxanthin and 9-Emytiloxanthin, J. Jpn. Oil. Chem., Soc., 45, 667-670 (1996).
51) 眞岡孝至、佐久嶋明世、Makust Coskun, 伊藤義博, Boreava orientalis のフェノール化合物の抗酸化活性, 日本油化学会誌, 45, 671-673 (1996).
52) 内野滋己、高橋進一、大栗直殻、眞岡孝至、高山史真子、橋本圭二、小塚睦夫, キューリーポイント直接導入装置を用いるTLC-MS法による生薬成分・天然有機化合物の迅速分析、Chromatography, 17, 195-201(1996).
53) Akiyo Sakushima, Maksut Coskun, Takashi Maoka and Sansei Nishibe, Dihydrobenzofuran
lignans from Boreava orientalis, Phytochemistry, 43, 1349-1354 (1996).
54) Takashi Maoka, A new apocarotenoid from marine shellfish, J. Nat. Prod., 60, 616-617 (1997).
55) Takashi Maoka, Kooichi Mochida, Yoko Okuda, Yoshihiro Ito and Yasuhiro Fujiwara, A novel
purple carotenoid, rhodobacterioxanthin, from Rhodobacter capsulatus, Chem. Pharm. Bull. 45,
1225-1227 (1997).
56) Akiyo Sakushima, Maksut Coskun, Takashi Maoka and Sansei Nishibe, Coumarin and somephenolic compounds of Boreava orientalis, Natural Medicines, 51, 383 (1997).
57) Takashi Maoka, Yoshihiro Ito, Akiyo Sakushima, Kosei Ohno, Maksut Coskun and Sansei
Nishibe, Comparison of antioxidative activity of phenolic compounds in Boreava orientalis and theirrelated compound, J. Jpn. Oil Chem. Soc. 46, 1399-1402 (1997).
58) Akiyo Sakushima, Shozo Ohnishi, Harumi Kubo and Takashi Maoka, Study of sinapinyl but-3enylglucosinolate (Boreavan A) and related compounds by mass spectrometry, Phytochemical
Analysis 8, 312-315 (1997).
59) Akiyo Sakushima, Makusut Coskun, Takashi Maoka and Sansei Nishibe, Separation of
guaiacylglycerol-8'-vanilic acid ester isomers from Boreava orientalis, Natural Products Letters, 11,4

31-36 (1997).
60) 内野滋己、高橋進一、大栗直殻、眞岡孝至、小塚睦夫、嶋田康男、橋本圭二, 熱分解及び燃焼ガスGC/MS法による香気成分の組成分析, Chromatography 19, 255-231(1998).
61) K. Miyake, H. Sakurai, K. Kanamura, T. Maoka and Y. Ito, A biomimetic electron releasing
device: capacitively connected glow discharge electrode, Naturwissenscaften 85, 603-605 (1998).
62) Kenji Takii, Takashi Maoka, Manabu Seoka, Taizo Kondo, Motoji Nakamura, Hisao Kitano and
Hidemi Kumai, Preliminary assessment of dietary yeast, Saccharomyces cerevisiae, Protein for red
sea bream, SUISANZOUSHOKU, 47(1), 71-76 (1999).
63) Masahiro Ookubo, Miyuki Tsushima, Takashi Maoka and Takao Matsuno, Carotenoids and their
metabolism in the goldfish Carassius auratus, Comp. Biochem. Physiol., 124B, 333-340 (1999).
64) Takao Matsuno, Masahiro Ohkubo, Yutaka Toriiminami, Miyuki Tsushima, Seiichi Sakaguchi,
Toshio Minamai and Takashi Maoka, Carotenoids in food chain between freshwater fish and aquatic
insects, Comp. Biochem. Physiol., 124B, 341-345 (1999)
65) Amelia P.Guevara, Carolyn Vargas, Hiromu Sakurai, Yasuhiro Fujiwara, Keiji Hashimoto,Takashi Maoka, Mutzuo Kozuka, Yoshihiro Ito, Harukuni Tokuda and Hoyoku Nishino, An
antitumor promoter from Moringa oleifera Lam., Mutation Research, 440, 181-188 (1999).
66) 秋元直茂、眞岡孝至、藤原靖弘、橋本圭二、FAB CID-MS/MSによるカロテノイドの分
析、J. Mass Spectrom. Soc. Jpn., 48, 32-41(2000).
67) Akira Murakami, Mamiko Nakashima, Tetukuni Koshiba, Takashi Maoka, Hoyoku Nishino,
Masamichi Yano, Takashi Sumida, Oe Kyung Kim. Koichi Koshimizu and Hajime Ohigashi.,
Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated
leukocyte, Cancer Lett., 149, 115-123 (2000).
68) Tenji Konishi, Takao Konoshima, Takashi Maoka and Yasuhiro Fujiwara, Novel diterpenoids,
excoecarins M and N from the resinous wood of Excoecaria agallocha, Tetrahedron Lett., 41, 34193422 (2000).
69) Miyuki Tsushima, Eisaku Mune, Takashi Maoka and Takao Matsuno, Isolation ofstereoisomeric epoxy carotenoids and new acetylenic carotenoid from the common freshwater goby
Rhinogobius brunneus, J. Nat. Prod., 63, 960-964 (2000).
70）Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto, Satomi Takeda, Sanae Takagagaki and
Kazuko Ida, A new retro-carotenoid from the petals of the Californian yellow poppy Eschscholtzia
californica, J. Nat. Prod., 63, 1288-1289 (2000).
71） 秋山真一，滝井健二，眞岡孝至，中川雅雄，北野尚男，熊井英水，酵母タンパク質に対するマダイの嗜好性と利用性，水産増殖，49, 47-52 (2001).
72) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto and Naoshige Akimoto, Isolation of aseries of apocarotenoids from the fruits of the red paprika Capsicum annuum L. J. Agric. Food
Chem., 49, 1601-1606 (2001).
73) Yasuhiro Fujiwara and Takashi Maoka, Structure of pittosporumxanthins A1 ans A2, a novel C69
carotenoids from the seeds of Pittosporum tobira, Tetrahedron Lett., 42, 2693-2696 (2001).

574) Shinichi Takaichi, Takashi Maoka, Satoshi Hanada and Johannes F. Imhoff, Dihydroxylycopene
diglucoside diesters : a novel class of carotenoids from the phototrophic purple sulfur bacteria
Halorhodospira abdelmalekii and Halorhodospira halochloris, Arch Microbiol, 175, 161-167(2001).
75) Takao Matsuno, Miyuki Tsushima and Takashi Maoka, Salmoxanthin. Deepoxysalmoxanthin
and 7,8-dideepoxysalmoxanthin from the salmon Oncorynchus keta, J. Nat. Prod., 64, 507-510(2001).
76) Takashi Maoka, Keiji Hashimoto, Naoshige Akimoto and Yasuhiro Fujiwara, Structures of fivenew carotenoids from the oyster Crassostrea gigas, J. Nat. Prod., 64, 578-581 (2001).
77) Takashi Maoka, Yukiko Goto, Kaori Isobe, Yasuhiro Fujiwara, Keiji Hashimoto and Kooichi
Mochida, Antioxidative activity of capsorubin and related compounds from paprika (Capsicum
annuum), J. Oleo Sci., 50, 663-665 (2001).
78) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto and Naoshige Akimoto, Capsanthone 3, 6epoxide, a new carotenoid from the fruits of the red paprika Capsicum annuum L. J. Agric. Food
Chem., 49, 3965-3968 (2001).
79) Takashi Maoka, Kooich Mochida, Mutsuo Kozuka, Yoshihiro Ito, Yasuhiro Fujiwara, Keiji
Hashimoto, Fumio Enjo, Masakazu Ogata, Yoshitoshi Nobukuni, Harukuni Tokuda, and Hoyoku
Nishino, Cancer chemo preventive activity of carotenoids in the fruits of red paprika Capsicum
annuum L., Cancer Lett., 172, 103-109 (2001).
80) Yasuhiro Fujiwara, Hisashi Maruwaka, Fujio Toki, Keiji Hashimoto and Takashi Maoka,
Structure of three new carotenoids with a 3-Methoxy-5-keto-5,6-seco-4,6-cyclo- end group fromthe seeds of Pittosporum tobira, Chem. Pharm. Bull., 49, 985-987 (2001).
81) Shin-ichi Akiyama, Kenji Takii, Takashi Maoka, Kohodo Otaka, Yasunori Sano, and Hidemi
Kumai, Dietary yeast protein, Candida utilis rather than Rhodotorula glutinis, sustains growth
performance of juvenile red sea bream, SUISANZOSHOKU, 49, 219-224 (2001).
82) Shinichi Takaichi, Takashi Maoka and Kazumori Masamtoto, Myxoxanthophyll in
Synechocystis sp. PCC 6803 is myxol 2’-dmethyl-fucoside, (3R,2’S)-myxol 2’-(2,4-di-O-methyl-αL-fucoside), not rhamnoside, Plant Cell Physiol, 42, 756-762 (2001).
83) Philipp Krubasik, Shinichi Takaichi, Takashi Maoka, Miki Kobayashi, Kazumori Masamoto andGerhard Sandmann, Detailed biosynthetic pathway to decaprenoxanthin diglucoside in
Corynebacterium glutamicum and identification of novel intermediate, Arch. Microbiol, 176, 217223 (2001).
84) Miyuki Tsushima, Takashi Maoka and Takao Matsuno, Structure of carotenoids with 5,6dihydro--end groups from the spindle shell Fushinus perplexus, J. Nat. Prod., 64, 1139-1142(2001)
85) Shinichi Takaichi, Takashi Maoka, Mitsumori Yamada, Katsumi Matsuura, Yuji Haikawa andSatoshi Hanada, Absence of carotenes and presence of a tertiary methoxy group in a carotenoid froma Thermophilic Filamentous photosynthetic bacterium Roseiflexus castenholzii, Plant Cell Physiol,
42, 1355-1362 (2001).
86) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto and Naoshige Akimoto, Rapid
Identification of carotenoids in a combination of liquid chromatography / UV-visible absorption
spectrometry by photodiode-array detector and atmospheric pressure chemical ionization mass6

spectrometry (LC/PAD/APCI-MS), J. Oleo Sci., 51, 1-9 (2002).
87) Shusuke Nakazawa, Takashi Maoka, Haruki Uemura, Yoshihiro Ito and Hiroji Kanbara, Malaria
parasites civing rise to recrudesence in vitro, Antimicrb. Agents Chemother., 46, 958-965 (2002).
88) Yukie Yoshii, Shinichi Takaichi, Takashi Maoka, Satoshi Hanada and Isao Inoue,
Characterization of two unique carotenoid fatty acid esters from Pterosperma cristatum(Prasinophceae, Chlorophyta), J. Phycol. 38, 297-303 (2002).
89) Yasuhiro Fujiwara, Keiji Hashimoto, Kiyoshi Manabe and Takashi Maoka, Structures of
tobiraxanthins A1, A2, A3, B, C and D, new carotenoids from seeds of Pittosporum tobira,Tetrahedron Lett., 43, 4385-4388 (2002).
90) Masayuki Horiuchi, Takashi Maoka, Noriyasu Iwase and Keiichiro Ohnishi, Reinvestigation of
porritoxin, a phyototoxin of Alternaria porri, J. Nat. Prod., 65, 1204-1205 (2002).
91) Kodo Otaka, Kumi Hidaka, Atsuko Nakajima and Takashi Maoka, Chracterization andapplication of sugar components produced by autolysis of Hansenula anomala SB1020, J. Biol.
Macromol, 2, 64-74 (2002).
92) Daizo Takahashi, Takashi Maoka, Miyuki Tsushima, Kazuyoshi Fujitani, Mutsuo Kozuka, Takao
Matsuno and Tetsuro Shingu, New quinone sulfates from the crinoids Tropiometra afra macrodiscus
and Oxycomanthus japonicus. Chem. Pharm. Bull. 50, 1609-1612 (2002).
93) Takashi Maoka, Miyuki Tsushima and Hoyoku Nishino, Isolation and characterization of
dinochrome A and B, Anti-carcinogenic active carotenoids from the fresh water red tide Peridinium
bipes, Chem. Pharm. Bull. 50, 1630-1633 (2002).
94) Shinichi Takaishi, Hirozo Oh-oka, Takashi Maoka, Deborach O. Jung, and Michael T. Madigan,
Novel carotenoid glucoside esters from alkaliphilic heliobacteria, Arch. Microbiol, 179, 95-100(2003).
95) Tenji Konishi, Kiyonori Yamazoe, Takao Konoshima, Takashi Maoka, Yasuhiro Fujiwara, andKazumoto Miyahara, New bis-secolabdane Ddterpenoids from Excoecaria agallocha, J. Nat. Prod.,66, 108-111 (2003).
96) Wataru Aoi, Yuji Naito, Kunishiro Sakuma, Masashi Kuchide, Harukuni Tokuda, Takashi
Moaka, Shinya Toyokuni, Shigenori Oka, Masahiro Yasuda, and Toshikazu Yoshikawa, Astaxanthin
limits exercise-induced skeletal and cardiac muscle damage in mice, Antioxidants & Redox
Signaling, 5, 139-144 (2003).
97) Yukie Yoshii, Shinichi Takaichi, Takashi Maoka, and Isao Inouye, Photosynthetic pigmentcomposition in the primitive green alga Mesostigma viride (Prasinophyceae): Phylogenetic andevolutionary implications, J. Phycol. 39, 570-576 (2003).
98） 井上弘明、立石亮、木村淑子、小沢裕子、磯部勝孝、野村和成、眞岡孝至、橋本秀樹、廣田才之、野菜類のクロロフィル含量とカロテノイド、ビタミンＣ・Ｅならびに無機質含量に関する研究、日本食生活学会誌、13, 271-278 (2003).
99) Tsunehiro Aki, Kazutaka Hachida, Megumi Yoshinaga, Yuko Katai, Takashi Yamada, Seiji
Kawamoto, Toshihide Kakizono, Takashi Maoka, Seiko Shigeta, Osamu Suzuki, and Kazuhisa Ono,
Thraustochytrid as a potential source of carotenoids, J. Am. Oil. Chem. Soc., 80, 789-794 (2003).
100) Masayuki Horiuchi, Naoshige Akimoto, Keiichi Ohnishi, Masakazu Yamashita, and Takashi
7

Maoka, Rapid and simultaneous determination of tetra cyclic peptide phytotoxins, tentoxin,
isotentoxin and dihydrotentoxin, from Altenaria porii by LC/MS, Chromatography, 24, 109-116(2003).
101) Takashi Maoka, Naoshige Akimoto, Yasuhiro Fujiwara, and Keiji Hashimoto, Structure of
New carotenoids with the 6-oxo-κ end group from the fruits of paprika, Capsicum annuum, J. Nat.
Prod., 67, 115-117 (2004).
102) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto, and Naoshige Akimoto, Characterizationof epoxy carotenoids by fast atom bombardment collision-induced dissociation MS/MS, Lipids, 39,
179-183 (2004).
103) Yuji Naito, Kazuhiko Uchiyama, Wataru Aoi, Goji Hasegawa, Naoto Nakamura, Norimasa
Yoshida, Takashi Maoka, Jiro Takahashi, and Toshikazu Yoshikawa, Prevention of diabetic
nephropathy by treatment with astaxanthin in diabetic db/db mice, BioFactors, 20, 49-59 (2004).
104) Yoshiko Satomi, Norimochi Misawa, Takashi Maoka, and Hoyoku Nishino, Production ofphytoene, a carotenoid, and induction of connexin 26 in transgenic mice carrying the phytoene
synthase gene crtB, Biochem. Biophys. Res. Comm., 320, 398-401 (2004).
105) Masayuki Horiuchi, Keiichiro Ohnishi, Masakazu Yamashita and Takashi Maoka,
LC/PAD/APCI-MS for the characterization and analysis of porritoxin and its related compounds
from Alternaria porri. Chromatography, 25, 55-59 (2004).
106) Shinichi Takaichi, Takashi Maoka, Naoshige Akimoto, Dimitry Yu. Sorokin, Horia Banciu and
J. Gijs Kuenen, Two novel yellow pigments natronochrome and chloronatronochrome from thenatrono(alkali)philic sulfur-oxidizing bacterium Thialkalivibrio versutus strain ALJ 15, Tetrahedron
Lett., 45, 8261-8427 (2004).
107) Sanae Kishimoto, Takashi Maoka, Masayoshi Nakayama and Akemi Ohmiya, Carotenoid
composition in petals of chrysanthemum (Dendranthema grandiflorm (Ramat.) Kitamura),
Phytochemistry, 65, 2781-2787 (2004).
108) Kenji Takii, Shin-ichi Akiyama, Takashi Maoka, Kumi Hidaka, Kodo Otaka, Manabu Seoka
and Hidemi Kumai, Evaluation of dietary yeast autolysates from red sea bream, Pagrus major,
Suisanzoshoku, 52, 387-394 (2004).
109) Shinichi Takaichi, Mari Mochimura, Takashi Maoka and Hiroshi Katho, Myxol and 4ketomyxol 2’-fucosides, not rhamnosides, from Anabaena sp. PCC 7120 and Nostoc puncitiforme
PCC 73102, and proposal for the biosynthetic pathway of carotenoids, Plant Cell Physiol., 46, 497504 (2005).
110) Tohru Tsuchiya, Shinichi Takaichi, Norihiko Misawa, Takashi Maoka, Hideaki Miyashita, andMamoru Mimuro, The cyanobacterium Gloeobacter violaceus PCC 7421 uses bacterial-type
phytoene desaturase in carotenoid biosynthesis, FEBS Lett., 578, 2125-2129 (2005).
111) Zhongcun Pang, Kodo Otaka, Takashi Moaka, Kumi Hidaka, Sumio Ishijima, Masayuki Oda,
and Masatake Ohnishi, Structure of β-glucan oligomer from laminarin and its effect on humanmonocytes to inhibit the proliferation of U937 cells, Biosci. Biotechnol. Biochem., 69, 553-558(2005).
112) Yukie Yoshii, Shinichi Takaichi, Takashi Moaka, Shoichiro Suda, Hiroshi Sekiguchi, Takeshi
Nakayama, and Iso Inouye, Variation of siphonaxanthin series among the genus Nephroselmis(Prasinophyceae, Chlorophyta), including a novel primary methoxy carotenoid, J. Phycol., 41, 827-8

834 (2005).
113) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto, and Naoshige Akimoto, Structures of
new carotenoids with a 3,4-dihydroxy--end Group from the oyster Crassostrea gigas, Chem.
Pharm. Bull., 53, 1207-1209 (2005).
114) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto, and Naoshige Akimoto, Structure of new
carotenoids from the corbicula clam Corbicula japonica, J. Nat. Prod., 68, 1341-1344 (2005).
115) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto, and Naoshige Akimoto, Carotenoids inthree species of corbicula Clams, Corbicula japonica, Corbicula sandai, and Corbicula sp. (Chinese
freshwater corbicula clam), J. Agric. Food Chem., 53, 8357-8364 (2005).
116) Sanae Kishimoto, Takashi Maoka, Katsuhiko Sumitomo, and Akemi Ohmiya, Analysis ofcarotenoid composition in petals of calendula (Calendula officinalis L.) Biosci. Biotechnol. Biochem.,69, 2122-2128 (2005).
117) Shinichi Takaichi, Mari Mochimura, and Takashi Maoka, Presence of free myxol and 4hydroxymyxol and absence of myxol glucosides in Anabaena variabilis ATCC 29413, and proposalof a biosynthetic pathway of carotenoids, Plant Cell Physiol., 47, 211-216 (2006).
118) Masayoshi Nakayama, Msami Miyashita, Takashi Maoka, Masafumi Yagi and Naoko Fukuta,
A carotenoid-derived yellow Eustoma Screened under blue and ultraviolet lights, J. Japan. Soc. Hort.
Sci. 75, 161-165 (2006).
119) Ryo Yoshioka, Tsutomu Hayakawa, Kumiko Ishizuka, Aditya Kulkarni, Yukimasa Terada,
Takashi Moaka and Hideo Etoh, Nitration reaction of astxanthin and β-carotene by peroxynitrite,
Tetrahedron Lett., 47, 3637-3640 (2006).
120) Masayuki Horiuchi, Harukuni Tokuda, Keiichiro Ohnishi, Masakazu Yamashita, Hoyoku
Nishino and Takashi Maoka, Porritoxins, metabolites of Alternaria porii, as anti-tumor-promoting
active compounds, Nat. Prod. Res., 20, 161-166 (2006).
121） 眞岡孝至、持田晃一、小塚睦夫、圓城文男、口出将司、信國好俊、徳田春邦、西野
輔翼、パプリカ抽出物およびカプサンチンの一酸化窒素またはペルオキシナイトライトによって誘起される発がんに対する予防効果、食品・臨床栄養、1, 7-14 (2006).
122) 赤桐里美、日高久美、眞岡孝至、大高洽堂、谷本文男、森山達裁、小川 正、マウスに対する酵母 Rhodotorula glutinis および Hansenula anomala の免疫賦活活性、食品・臨床
栄養、1, 15-22 (2006).
123) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto and Naoshige Akimoto,
5-Hydroxy-seco-carotenoids from Pittosporum tobira, Phytochemistry, 67, 2120-2125 (2006).
124) Takashi Maoka and Naoshige Akimoto, 2,3’-Dihydroxycanthaxanthin, A new carotenoid with a2-hydroxy-4-oxo-β-end group from the hermit crab, Paralithodes brevipes, Chem. Pharm. Bull., 54,
1462-1464 (2006).
125) Shinichi Takaichi, Takashi Maoka, Naoshige Akimoto, Shams Tabrez Khan and Shigeaki
Harayama, Major carotenoid isolated from Paracoccus schoinia NBRC 100637T is adonixanthin
diglucoside, J. Nat. Prod., 69, 1823-1825 (2006).

9126) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto, and Naoshige Akimoto, Characterizationof fucoxanthin and fucoxanthinol esters in the Chinese surf clam, Mactra chinensis, J. Agric. Food
Chem, 55, 1563 – 1567 (2007).
127) Kazutoshi Shindo, Kanae Mikami, Emiko Tamesada, Shinich Takaichi, Kyoko Adachi,
Norihiko Misawa and Takashi Maoka, Diapolycopendionic acid xylosyl ester, a novel glyco-C30carotenoic acid produced by a new marine bacterium Rubritalea squallenifaciens, Tetrahedron Lett.,
48, 2725-2727 (2007).
128） 和田孝、伊藤伸一、湯浅義三、眞岡孝至、HPLC によるヒト血清カロテノイドの分
析、食品・臨症栄養、2, 15-26 (2007).
129) Takashi Maoka, Naoshige Akimoto, Koji Ishiguro, Masaru Yoshinaga and Makoto Yoshimoto,
Carotenoids with a 5,6-dihydro-5,6-dihydroxy-β-end group, from yellow sweet potato “Benimasari”,
Ipomoea batatas LAM, Phytochemistry, 68, 1740-1745 (2007).
130) Takahi Maoka and Seiichi Ando, Isolation of purple nor-carotenoid, 2’,3’-dihydroroserythrin,
from crawfish Procambarus clarkii, Fisheries Science, 73, 967-968 (2007).
131) Xiao-Feng Wang, Cong-Hang Zhan, Takashi Maoka, Yuji Wada and Yasuhiro Koyama,
Fabrication of dye-sensitized solar cell using chlorophylls c1 and c2 and their oxidized forms c1’
and c2’ from Undaria pinnatifida (Wakame), Chem. Phys. Lett., 447, 79-85 (2007).
132) Tatushi Yoshida, Takashi Maoka, Swadesh K. Das, Kazuki Kanazawa, Mano Horinaka, Miki
Wakada, Yoshiko Satomi, Hoyoku Nishino, and Toshiyuki Sakai, Halocynthiaxanthin and priedininsensitize colon cancer cell lines to tumor neurosis factor-related apoptosis-inducing ligand. Mol.
Cancer Res. 5, 615-625 (2007).
133) Rie Suzuki, Aditya Kulkarni, Yuya Yomoda, Hirokazu Kawagishi, Yukimasa Terada, Takashi
Maoka, and Hideo Etho, Reaction of retinal with peroxynitrite, Biosci. Biotechnol. Biochem., 71,
2596-2599 (2007).
134) Rondey A, Herbert, Andrew Gall. Takashi Maoka, Richard J. Cogdell, Bruno Robert, Shinichi
Takaichi, and Stephanie Schwabe, Phototrphic pure sulfur bacteria as heat engines in the South
Andors black hole, Photosynth. Res., 95, 261-263(2008).
135) Emiko Manabe, Osamu Hanada, Yuji Naito, Katura Mizushima, Satomi Akagiri, Satoko
Adachi, Tomohisa Takagi, Satoshi Kokura, Takashi Maoka, and Toshikazu Yoshikawa, Astaxanthin
protects mesangial cells from hyperglycemia-induced oxidative signaling, J. Cell Biochem. 103,
1925-1937 (2008).
136) Takashi Maoka, Fumio Tanimoto, Mitsuhiko Sano, Kanji Tsurukawa, Takuo Tsuno, Satomi
Tsujiwaki, Katsuya Ishimaru,and Kenji Takii, Effects of dietary supplementation of ferulic acid andγ-oryzanol on integument color and suppression of oxidative stress in cultured red sea bream,
Pagrus major, J. Oleo Sci. 57,133-137 (2008).
137) Takashi Maoka and Naoshige Akimoto, Carotenoids and their fatty acid esters of spiny lobster
Panulirus japonicus, J. Oleo Sci. 57, 145-152 (2008) .
138) Izumi Konishi, Masashi Hosokawa, Tokutake Sashima, Takashi Maoka, Kazuo Miyashita,
Suppressive effects of alloxanthin and diatoxanthin from Halocynthia roretzi on LPS-induced
expression on pro-inflammatory genes in RAW264.7 cells, J. Oleo Sci. 57, 181-189 (2008) .
139) Takashi Maoka, Naoshige Akimoto, Yoshihiro Kuroda, Keiji Hashimoto and Yasuhiro Fujiwara,

10

Structure of a series of cycloaddition product of carotenoid with α-tocopherol, named
pittosporumxanthins, from the seeds of Pittosporum tobira, J. Nat. Prod., 71, 622-627 (2008).
140) Kazutoshi Shindo, Tomohisa Hasunuma, Emiko Asagi, Aya Sano, Eri Hotta, Noriko Minemura,
Chikahiro Miyake, Takashi Maoka, Norihiko Misawa, 4-Ketoantheraxanthin, a novel carotenoid
produced by the combination of the bacterial enzyme β-carotene ketolase CrtW and endogenous
carotenoid biosynthetic enzymes in higher plants, Tetrahedron Lett., 49, 3294-3296 (2008).
141） 中嶋貴司、和田 孝、樽井直子、伊藤伸一、湯浅義三、眞岡孝至、ヒト血清カロテ
ノイドの Ultra Performance Liquid Chromatography による迅速分析、食品・臨床栄養, 3, 1118 (2008).
142) Kazuyoshi Shindo, Emiko Asagi, Aya Sano, Eri Hotta, Noriko Minemura, Kanae Mikami,
Emiko Tamesada, Norihiko Misawa, Takashi Maoka, Diapolycopenedioic acid xylosyl esters A, B,
and C, Novel antioxidative glyco-C30-carotenoic acids produced by a new marine bacterium
Rhbritalea squalenifaciens, J. Antibiot. 61, 181-191 (2008).
143) Yukihiro Yamamoto, Masashi Hosokawa, Hideyuki Kurihara, Takashi Maoka, Kazuo
Miyazawa, Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D andtheir antiproliferative effects in human cancer cells, Bioorg. Medicinal Chem. Lett., 18, 4044-4046(2008).
144) Mari Mochimura, Hajime Masukawa, Takashi Maoka, Hatem E. Mohamed, Wim F. J. Vermaas,
Shinichi Takaichi, Substrate specificities and availability of fucosyltransferase and β-carotenehydroxylase for myxol 2’-fucoside synthesis in Anabaena sp. Strain PCC 7120 compared with
Synechocystis sp. strain PCC 6803, J. Bacteriol.,190, 6726-6733 (2008).
145) Shinichi Takaichi, Takashi Maoka, Naoshige Akimoto, Marvelisa L. Carmona, Yukiho
Yamaoka, Carotenoids in a Corynebacterineae, Gordonia terrae AIST-1: Carotenoid glucosyl
mycoloyl esters, Biosci. Biotechnol. Biochem., 72, 2651-2622 (2008).
146）Tsutomu Hayakawa, Aditya Kulkarni, Yukimasa Terada, Takashi Maoka, Hideo Etoh,
Reaction of Astaxanthin with peroxynitrite, Biosci. Biotechnol. Biochem., 72, 2716-2722 (2008).
147) Masako Iwai, Takasi Maoka, Masahiko Ikeuchi, Shinichi Takaichi, 2,2’-β-hydoxylase (Crt G)
is involved in carotenogenesis of both neoxanthin and 2-hydroxymyxol 2’-fucoside in
Thermosynechococcus elongates strain BP-1. Plant Cell Physiol., 49, 1678-1687 (2008).

148) Takashi Maoka, Naoshige Akimoto, Mi-Jin Yim, Masashi Hosokawa, Kazuo Miyashita, A new
C37-skeletal carotenoid from the clam, Paphia amabillis. J. Agric Food Chem., 56, 12069-12072(2008).
149) Kumi Hidaka, Yasuko Iwakawa, Takashi Maoka, Fumio Tanimoto, and Akira Oka, Viablechemical recycling of poly(carbonate) as a phosgene equivalent illustrated by the coproduction ofbisphenol A and carbohydrate carbonates, J. Mater Cycles Waste Manag, 11, 6-10 (2009).

150) Takashi Maoka, Sterically hindered carotenoids with 3Z,5Z configuration from the seeds oforiental bitter sweet, Celastrus orbiculatus, Phytochemistry, 70, 920-923 (2009).
151） Takashi Hashimoto, Yoshiaki Ozaki, Mayuko Taminato, Swadesh K. Das, Masashi Mizuno,
Kazuto Yoshimura, Takashi Maoka and Kazuki Kanazawa. The distribution and accumulation of11

fucoxanthin and its metabolites after oral administration in mice, Br. J. Nutr. 102, 242-248（2009）.
152) P. Anil Kumar, T. N. R. Srinivas, S. Takaichi, T. Maoka, Ch. Sasikala1, Ch. V. Ramana,
Phaeospirillum chandramohanii sp. nov., aphototrophic alphaproteobacterium with carotenoid
glycosides, International Journal of Systematic and Evolutionary Microbiology, 59, 2089–2093(2009).
153) Makoto Kusaba, Takashi Maoka, Ryouhei Morita, Shinichi Takaichi, A novel carotenoid
derivative, lutein 3-acetate, accumulates in senescent leaves of rice, Plant Cell Physiol,.50, 15731577 (2009)154) Shinichi Takaichi A Takashi Maoka, Mari Mochimaru, Unique carotenoids in the terrestrial
cyanobacterium Nostoc commune NIES-24: 2-hydroxymyxol 20-fucoside, nostoxanthin andcanthaxanthin, Curr Microbiol,Curr. Microbiol., 59, 413-419 (2009).
155) Yumika Okada, Masaharu Ishikura, and Takashi Maoka, Bioavailability of astaxanthin in
Haematococcus algal extract: The effects of timing of diet and smoking habits, Biosci. Biotechnol.
Biochem., 73, 1928-1932 (2009).
156) Chisato Tode, Takashi Maoka, Makiko Sugiura, Application of LC-NMR to analysis ofcarotenoids in foods, J. Sep. Sci. 32, 3659–3663 (2009).
157) Makoto Tsuboi, Hideo Etoh, Yuya Yomoda, Kyuki Kato, Hideaki Kato, Aditya Kulkarni,
Yukimasa Terada, Takashi Maoka , Hironobu Mori, Takahiro Inakuma, Nitration reaction of luteinwith peroxynitrite, Tetrahedron Lett., 51, 676-678 (2010).
158) Shinich Takaichi, Takashi Maoka, Kazuto Takasaki, Satoshi Hanada, Carotenoids ofGemmatimonas aurantiaca (Gemmatimonadetes): identification of a novel carotenoid, deoxyoscillol
2-rhamnoside, and proposed biosynthetic pathway of oscillol 2,2'-dirhamnoside, Microbiology, 156,
757-763 (2010).
159) Takashi Maoka, Naoshige Akimoto, Yukimasa Terada, Sadao Komemushi, Ryo Harada,
Naomi Sameshima, Yoshikazu Sakagami, Structure of minor carotenoids from crown-of-thorns
starfish, Acanthaster planci, J. Nat. Prod. 73, 675-678 (2010).
160) Maoka, Takashi; Akimoto, Naoshige; Murakoshi, Michiaki; Sugiyama, Keikichi; Nishino,
Hoyoku, Carotenoids in clams, Ruditapes philippinarum and Meretrix petechialis, J. Agric Food
Chem., 58, 5784-5788 (2010).
161) Hisayuki Horai, Masanori Arita, Shigehiko Kanaya, Yoshito Nihei, Tasuku Ikeda, KazuhiroSuwa, Yuya Ojima, Kenichi Tanaka, Satoshi Tanaka, Ken Aoshima, Yoshiya Oda, Yuji Kakazu,
Miyako Kusano, Takayuki Tohge, FumioMatsuda, Yuji Sawada, Masami Yokota Hirai, Hiroki
Nakanishi, Kazutaka Ikeda, Naoshige Akimoto, TakashiMaoka, Hiroki Takahashi, Takeshi Ara,
Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Steffen Neumann, Takashi Iida, Ken Tanaka,
Kimito Funatsu, Fumito Matsuura, Tomoyoshi Soga, Ryo Taguchi,f, Kazuki Saito and Takaaki
Nishioka, MassBank: a public repository for sharing mass spectral data for life sciences, J. Mass.
Spectrom. 45, 703–714 (2010).
162) Hiroshi Shimoda, Junji Tanaka, Shao-Jie Shan, and Takashi Maoka, Anti-pigmentary activityof fucoxanthin and its influence on skin mRNA expression of melanogenic molecules, Journal of
Pharmacy and Pharmacology 62, 1137–1145 (2010).

12163) Ayako Osawa, Yoko Ishii, Nao Sasamura, Marie Morita, Hiroaki Kasai, Takashi Maoka andKazutoshi Shindo, Characterization and antioxidative activities of rare C50 carotenoidssarcinaxanthin, sarcinaxanthin monoglucoside, and sarcinaxanthin diglucoside-obtained fromMicrococcus yunnanensis,J. Oleo. Sci. 59, 653-659 (2010).
164) Shinzo Hosoi, Takeyuki Tanaka, Yukiteru Katsumoto, Takashi Maoka, Toshio Fujiwara,
Masayuki Yamashita and Manabu Node, Straightforward approach to the discrimination of (4R)and (4S)-β-isocryptoxanthin from a conformationally insensitive CD Band, Natural ProductCommunications, 5, 1733-1736 (2010).
165) Tsutomu Tsuchida, Ryuichi Koga, Mitsuyo Horikawa, Tetsuto Tsunoda, Takashi Maoka,
Shogo Matsumoto, Jean-Christophe Simon and Takema Fukatsu: Symbiotic bacterium modifies
aphid body color. Science 330, 1102-1104 (2010).
166) Koji Ishiguro, Masaru Yoshinaga, Yumi Kai, Takashi Maoka, and Makoto Yoshimoto,
Composition, content and antioxidative activity of the carotenoids in yellow-fleshed sweet potato(Ipomoea batatas L.), Breeding Science, 60, 324-329 (2010).
167) Takashi Maoka and Naoshige Akiomoto,. Structures of minor carotenoids from the Japanesecommon catfish, Silurus asotus, Chem. Phram. Bull. 59, 140-145 (2011),
168) Takashi Maoka, Tetsuji Etho, Sanae Kishimoto and Syusaku Sakata, Carotenoids and theirfatty acid esters in the petals of Adonis aestivalis, J. Oleo. Sci., 60, 47-52 (2011).
169) Hiroko. Negishi, Takashi Maoka. Maria Nielekela, Naomi Yasui, Sachiko Juman, Jacob
Mtabaji, Tomohiro Miki, Yasuo Nara, Yukio Yamori, Katsumi Ikeda, New chromone derivatives
termininalianone from African plant Terminalia browni Fresen (Combreteceae) in Tanzania, J.
Asian Natr. Prod. Res., 13, 281-283 (2011).
170) Ponesakki Ganesan, Kenji Noda, Yuki Manabe, Takeshi Ohkubo, Yukihisa Tanakla, Takashi
Maoka, Tatsuya Sugawara, Takashi Hirata, Siphonaxanthin, a marine carotenoid from green algae,
effectively induces apoptosis in human leukemia (HL-60) cells, Biochem. Biophys. Acta. 1810, 497503 (2011).
171) Takashi Maoka, Tetsuji Etoh, Naoshige Akimoto, Hiroyuki Yasui, Novel carotenoid
pyropheophorbide A esters from abalone, Tetrahedron Lett., 52,.3012-3015 (2011).
172) Shinichi Takaichi, Takashi Maoka, Ch. Sasikata, Ch. V. Ramana, Keizo Shimada, Genus
specific unusual carotenoids in purple bacteria, Phaeospirillum and Roseospira: Structures andbiosyntheses Curr. Microbiol, 63, 75-80 (2011).
173) Sho-ichi Tsujiyama, Tomoko Nittaand Takashi Maoka, Biodegradation of polyvinyl alcohol byFlammulina velutipes in an unsubmerged culture. Journal of Bioscience and Bioengineering, 112,58-62 (2011).

174) Takashi Maoka, Naoshige Akimoto, Miyuki Tsushima, Sadao Komemushi, Takuma
Mezaki, Fumihito Iwase, Yoshimitsu Takahashi, Naomi Sameshima, Miho Mori, andYoshikazu Sakagami, Carotenoids in Marine Invertebrates Living along the Kuroshio
Current Coast, Marine Drugs, 9, 1419-1427 (2011).
175）大澤絢子、加藤友佳里、嶋谷真理、野寺和花、服部菜理、眞岡孝至、新藤一
敏、ヤシガニに含まれるカロテノイドとその抗酸化活性、日本家政学会誌、62,499-505 (2011).

13176）Makoto Tsuboi, Hideo Etoh, Kyuki Kato, Hiroki Nakatugawa, Hideki Kato, Yasunori Maejima,
Gaku Matumoto, Hironobu Mori, Masashi Hosokawa, Kazuo Miyashita, Harukuni Tokuda,
Nobukuni Suzuki, Takashi Maoka, Nitrocapsanthin and Nitrofucoxanthin, Respective Products of
Capsanthin and Fucoxanthin Reaction with Peroxynitrite, J. Agric. Food. Chem., 59, 10872-10578(2011).
177）Yasunori Maejima, Hiroki Nakatugawa, Daiki Ichida, Mayumi Maejima, Yasuo Aoyagi,
Takashi Maoka, Hideo Etoh, Functional compounds in fermented buckwheat sprouts. Biosci.
Biotech. Biochem, 75, 1708-1712 (2011).
178) Takashi Hashimoto, Yoshiaki Ozaki, Masashi Mizuno, Masaru Yoshida, Yosuke Nishitani,
Takeshi Azuma, Akitoshi Komoto, Takashi Maoka, Yuka Tanino, Kazuki Kanazawa,
Pharmacokinetic of fucoxanthin in human plasma after the oral adminidtration of kombu extract, Br.
J. Nutr,107, 1566-1569 (2012).
179) Shinzo Hosoi, Eri Shimizu, Muneaki Hidaka, Manabu Okumura, Kazuhiko Arimori, Mitsuko
Yamada, Takashi Tanaka, Takashi Maoka, Isao Ohtsuka, Akiyo Sakushima, and Manabu Node,Analysis of CYP3A inhibitory compounds in the fruits of pomegranate, Punica granatum, using
liquid chromatography/mass spectrometry, Food Function, 8, 2-9 (2011).
180) Takashi Maoka, Tetsuji Etoh, Alexandra V. Borodina, and Alexander A. Soldatov A series of
19’-Hexanoyloxyfucoxanthin derivatives from the sea mussel, Mytilus galloprovincialis, grown in
the Black Sea, Ukraine, J. Agric. Food Chem., 59, 13059–13064 (2011).
181) Hideo Etoh, Mika Suhara, Sinji Tokuyama, Hideaki Kato, Rie, Nakahigashi, Yasunori Maejima,
Masaharu Ishikura, Yukimasa Terada, and Takashi Maoka, Auto-Oxidation Products of Astaxanthin,
J. Oleo Sci. 61, 17-21 (2012).
182) Takashi Maoka, Junko Ochi, Miho Mori, and Yoshikazu Sakagami, Identification of
Carotenoids in the Freshwater Shellfish Unio douglasiae nipponensis, Anodonta lauta,
Cipangopaludina chinensis laeta, and Semisulcospira libertina , J. Oleo Sci. 61, 69-74 (2012).
183) Józsff Molnár, Julianna Serly, Rozália Pusztai, Irèn Vincze, Pèter Molnár, Györgyi Horváth,József Deli, Takashi Maoka, Attila Zalatnai, Harukuni Tokuda, and Hoyoku Nishino, Putative
Supramolecular Complexes Formed by Carotenoids and Xanthophylls with Ascorbic Acid toReverse Multidrug Resistance in Cancer Cells. Anticancer Research 32, 507-518 (2012).
184) Takashi Maoka, Harukuni Tokuda, Nobutaka Suzuki, Hideaki Kato, and Hideo Etoh, Antioxidative, Anti-tumor-promoting, and Anti-carcinogensis Activities of Nitroastaxanthin andNitrolutein, the Reaction Products of Astaxanthin and Lutein with Peroxynitrite, Marine Drugs, 10,1391-1399 (2012).
185) Takashi Maoka, Tetsuji Etoh, Ayako Osawa, Kazutoshi Shindo Characterization and Singlet
Oxygen Quenching Activity of (3R)-3-Hydroxy-4-Ketotorulene and (3R)-3-Hydroxy-4-Ketoto-γcarotene from the Yeast Xanthophyllomyces dendrorhrous , J. Oleo Sci. 61, 401-406 (2012).
186) Hiroshi Shimoda, Shao-Jie Shan, Junji Tanaka and Takashi Maoka, β-Cryptoxanthin
suppresses UVB-induced melanogenesis in mouse: involvement of the inhibition of prostaglandin
E2 and melanocyte-stimulating hormone pathways, Journal of Pharmacy and Pharmacology, 64,
1165–1176 (2012).
187) Shinich Takaichi, Mari Mochimaru, Hiroko Uchida, Akio Murakami, Euichi Hirose, Takashi

14

Maoka, Tohru Tsuchiya, Mamoru Mimuro, Opposite chirality of α-carotene in unusual
Cyanobacteria with unique chlorophylla, Acaryochloris and Prochloroccus, Plant Cell Physiol., 53,
1881-1888 (2012).
188) 成田正直、眞岡孝至、蛯谷幸司、西野輔翼、オホーツク海のホタテガイ赤橙色貝柱における一般成分および赤色色素の同定と抗酸化作用について、日本水産学会誌, 79, 48-54(2013).
189) Takashi Maoka, Hiroyuki Yasui, Aya Ohmori, Harukuni Tokuda, Nobutaka Suzuki, Ayako
Osawa, Kazutoshi Shindo, and Takashi Ishibashi, Anti-oxidative, anti-tumor-promoting, and anticarcinogenic activities of adonirubin and adonixanthin, J. Oleo. Sci. 62, 181-186 (2013).
190) Hayato Maeda, Shuuichi Saito, Nozomi Nakamura, and Takashi Maoka, Paprika pigments
attenuate obesity-Induced Inflammation in 3T3-L1 adipocytes, ISRN Inflammation, 2013, Article ID
763758, 9 pages
191) T. Kuroki, S. Ikeda, T. Okada , T. Maoka, A. Kitamura, M. Sugimoto, S. Kume, Astaxanthinameliorates heat stress-induced impairment of blastocyst development In Vitro: –astaxanthin
colocalization with and action on mitochondria– J. Assist Reprod Genet, 30, 623-631 (2013).
192) Harukuni Tokuda, Takashi Maoka, Nobutaka Suzuki, ,Judit Hohmann, Andrea Vasas, HelgaEngi, Iliona Mucsi, Ulrike Olszewski, Gerhard Hamilton, Leonard Ameral and Joseph Molnar,
Effects of Two Disiloxanes ALIS-409 and ALIS-421 on Chemoprevention in Model Experiments
AR4, Anticancer Reserch, 33, 2021-2028 (2013).
193）Seon-Kang Choi, Ayako Osawa, Takashi Maoka, Jun-ichiro Hattan, Kei Ito, Ai Uchiyama,
Mai Suzuki, Kazutoshi Shindo, and Norihiko Misawa 3-β-Glucosyl-3-β-quinovosyl zeaxanthin, anovel carotenoid glycoside synthesized by Escherichia coli cells expressing the Pantoea ananatis
carotenoid biosynthesis gene cluster. Appl Microbiol Biotechnol, 97, 8479-8486 (2013).
194) 大澤絢子、伊東桂衣、内山 愛、鈴木真衣、伊東久美子、福尾菜美、眞岡孝至、新藤一敏、十脚目甲殻類に含有されるカロテノイドに関する研究、日本家政学会誌, 64, 443-450(2013).
195) Hisashi Harada, Takashi Maoka, Ayako Osawa, Jun-ichiro Hattan, Hirosuke Kanamoto,
Kazutoshi Shindo, Toshihiko Otomatsu, Norihiko Misawa, Construction of transplastomic lettuce(Lactuca sativa) dominantly producing astaxanthin fatty acid esters and detailed chemical analysis ofgenerated carotenoids, Transgenic Res. 23, 303-315 (2014).
196) Miho Takemura, Takashi Maoka, Norihiko Misawa, Carotenoid anlaysis of a liverwort
Marchantia polymorpha and functional identification of its lycopene β- and ε-cyclase genes, Plant
Cell Physiol. 55, 194-200 (2014).
197) 成田正直, 坂東忠男, 眞岡孝至, 麻生真悟,佐藤暁之, 宮崎亜希子, 清水茂雅, 宗谷
産イシモズクを用いた冷凍食品の開発, 水産技術，6, 185-192 (2014).
198) Takashi Maoka, Takashi Kuwahara, and Masanao Narita, Carotenoids of sea angels Clione
limacina and Paedoclione doliiformis, from the perspective of food chain, Marine Drugs, 12, 14601470 (2014).
199) T. Takahashi, K. Nishida, T. Sawabe, T. Maoka, K. Miyashita, H. Hosokawa, Identification of
a novel carotenoid, 2-isopentenylsaproxanthin, by Jejuia pallidilutea strain 11shimoA1 and its

15increased production under alkaline condition, Appl. Microbiol Biotechnol, 98, 6633-6640 (2014).
200) Yumiko Yamano, Takashi Maoka, Akimori Wada, Synthesis of (3S,3’S)- and mesoStereoisomers of Alloxanthin and Determination of Absolute Configuration of Alloxanthin Isolated
from Aquatic Animals, Marine Drugs, 12, 2623-2632 (2014).
201) Chikako Tani, Takashi Maoka, Mineto Tani, Yasuo Moritomo, Toru Okada, Go Kitahara andHiromu Katamoto, Accumulation of Xanthophylls from the Phaffia Yeast (Xanthophyllomyces
dendrorhrous ) in Calves. J. Oleo Sci. 63, 943-951 (2014).
202) Ayako Osawa, Kumiko Ito, Nami Fukuo, Takashi Maoka, Hideki Tsuruoka, Kazutoshi Shindo,
Changes of carotenoids in Atlantic salmon by heat cooking and the singlet oxygen quenchingactivities of the artificially produced carotenoids. Journal of Food Processing & Technology
2014:5:332.
203) Tohru Ariizumi, Sanae Kishimoto, Ryo Kakami, Takashi Maoka, Hideki Hirakawa, Yutaka
Suzuki, Yuko Ozeki, Kenta Shirasawa; Stephane Bernillon, Yoshihiro Okabe, Annick Moing, Erika
Asamizu, Chridtophe Rothan, Akemi Ohmiya, Hiroshi Ezura, Identification of the Carotenoid
Modifying Gene PALE YELLOW PETAL as an Essential Factor in Xanthophyll Esterification andYellow Flower Pigmentation in Tomato (Solanum lycopersicum). The Plant Journal, 79, 453-465(2014).
204) Masashi Yuasa, Akitoshi Kitamura, Takashi Maoka, Takashi, Sakudoh, Toru Shimada, andKozo Tsuchida, Astaxanthin and lutein compete for accumulation into the middle silk gland andproduce a red cocoon of Bombyx mori via Yellow cocoon gene-dependent control. Journal of Insect
Biotechnology and Sericology, 83, 1-11 (2014).
205) Takashi Maoka, Miho Takemura, Harukuni Tokuda, Nobutaka Suzuki, and Norihiko Misawa,
4-Ketozeinoxanthin, a novel carotenoid produced in Escherichia coli through metabolic engineering
using carotenogenic genes of bacterium and liverwort, Tetrahedron Lett, 55, 6708-6710 (2014).
206) Mifo Takemura, Takashi Maoka, and Norihiko Misawa, Biosynthetic routes of hydroxylated
carotenoids (xanthophylls) in Marchanita polymorpha, and production of novel and rare
xanthophylls through pathway engineering in Escherichia coli, Planta (2014).
207) Akihiko Nagao, Takashi Maoka, Hiroshi Ono, Eiichi Kotake-Nara, Miyuki Kobayashi, and Mie
Tomita A 3-hydroxy β-end group in xanthophylls is preferentially oxidized to a 3-oxo ϵ-end group in
mammals J. Lipid Res. 56, 449-462 (2015).
208) Yumiko Yamano, Kotaro Ematsu, Hiromasa Kurimoto, Takashi Maoka, and Akimori Wada,
Total synthesis of gobiusxanthin stereoisomers and their application to determination of absoluteconfigurations of natural products: Revision of reported absolute configuration of epigobiusxanthin,
Mar. Drugs, 13, 159-172 (2015).
209) Takashi Maoka, Yumiko Yamano, Akimori Wada, Tetsuji Etho, Yukimasa Terada, Harukuni
Tokuda, and Hoyoku Nishino, Oxidative Metabolites of Lycopene and γ-Carotene in Gac(Momordica cochinchinensis), J. Agric. Food Chem. 63, 1622-1630 (2015).
210) Yasuteru Sano, Yuta Nakano, Masatoshi Omoto, Masatoshi Takao, Eiji Ikeda, Atsunori Oga,
Kazuo Nakamichi, Masayuki Saijo M, Takashi Maoka, Hironori Sano, Motoharu Kawai, Takashi
Kanda, Rituximab-associated progressive multifocal leukoencephalopathy derived from nonHodgkin lymphoma: neuropathological findings and results of mefloquine treatment. Intern Med. 54,
965-970 (2015).

16211) Shinich Takaichi and Takashi Maoka, Identification and spectroscopic characterization ofneurosporene, Biotechol Lett. 37, 2027-2031 (2015).
212) Makiko Furubayashi, Mayu Ikezumi, Shinichi Takaichi, Takashi Maoka, Hisashi Hemmi,
Takuya Ogawa, Kyoichi Saito, Alexander V. Tobias, and Daisuke Umeno, A highly selective
biosynthetic pathway to non-natural C50 carotenoids assembled from moderately selective enzymes.
Nature Communications 6:7534 DOI:10.1038 (2015).
213) Azusa Nishino, Takashi Ichihara, Takeshi Takaha, Takashi Kuriki, Hideko Nihei, Kazuhisa
Kawamoto, Hiroyuki Yasui, and Takashi Maoka, Accumulation of paprika carotenoids in humanplasma and erythrocytes. J. Oleo Sci. 64, 1135-1142 (2015).
214) Miho Takemura, Takashi Moaka, Ayako Osawa, Haruka Higashinaka, Hiroshi Shimada,Kazutoshi Shindo, and Norihiko Misawa, (6E) and (6Z)-9’-Aporhodoxanthinone, novel carotenoids
produced in zeaxanthin-synthesizing-Escherichia coli by redox stress Tetrahedron Letters, 56, 60636055 (2015).
215) Takashi Maoka, Syu Nakachi, Ryouhei Kobayashi, Miho Mori, and Yoshikazu Sakagami, A
new carotenoid, 9Z,9’Z-tetrahydroastaxanthin, from the sea cucumber Plesiocolochirus minutus,
Tetrahedron Lettter, 56, 5954-5955 (2015).
216) Azusa Nishino, Takashi Maoka, and Hiroyuki Yasui, Analysis of reaction products ofastaxanthin and its acetate with reactive oxygen species using LC/PDA ESI-MS and ESR
spectrometry, Tetrahedron Letters, 57, 1967-1970 (2016).
217) Yoko Yoshihisa, Tsugunobu Andoh, Kenji Matsunaga, Mati UrRehman, Takashi Maoka, andTadamichi Shimizu, Efficacy of astaxanthin for the treatment of atopic dermatitis in a murine model,
PLOS ONE DOI:10.1371/journal.pone.0152288 March 29, 2016.
218) Takashi Maoka, Azusa Nishino, Hiroyuli Yasui, Yumiko Yamano, and Akimori Wada, Antioxidative Activity of Mytiloxanthin, a Metabolite of Fucoxanthin in Shellfish and Tunicates, Marine
Drugs, 14 (5), 93; doi:10.3390/md1450093, 2016219) Azusa Nishino, Hiroyuli Yasui, and Takashi Maoka, Reaction of Paprika Carotenoids
Capsanthin and Capsorubin with Reactive Oxygen Species J. Agric Food Chem. 64, 4786-4792(2016).
220) Muhammad Zubair Khan, Miho Takemura, Takashi Maoka, Motoyasu Otani, and Norihiko
Misawa, Carotenoid analysis of sweet potato Ipomoea batatas and functional identification of its
lycopene β- and ε-cyclase genes, Naturforschung C, 71, 313-322 (2016).
221) Takashi Maoka, Motoyasu Otani, Muhammad Zubair Khan, Miho Takemura, Jun-ichiro Hattan,
and Norihiko Misawa, Novel carotenoids produced on the interaction of the foreign carotenoid
ketolase CrtW and endogenous epoxycarotenoids unique to sweet potato tubers, Tetrahedron Letters
57, 4746-4748 (2016).
222) Azusa Nishino, Hiroyuki Yasui, Takashi Maoka, Reaction and scavenging mechanism of βcarotene and zeaxanthin with reactive oxygen species. J. Oleo. Sci., 66, 77-84 (2017).
223）Yumiko Yamano, Yuya Nishiiyama, Atsushi Aoki, Takashi Maoka, and Akimori Wada, Total
synthesis of lycopene-5,6-diol and γ-carotene-5’,6’-diol stereoisomers and their HPLC separation,
Tetrahedron, 73, 2043-2052 (2017).
224）眞岡孝至、安井菜穂美、根岸裕子、池田克己、天海智博、麹菌発酵大豆培養物（イ17ムバランス）の Th2 サイトカイン抑制作用とその活性成分について、食品・臨床栄養、
e2017, 1-9 (2017).
225) Takashi Maoka, Wataru Sato, Hidetada Nagai, and Toshiyuki Takahashi, Carotenoids of Red,
Brown, and Black Specimens of Plectropomus lepardus, the Coral Trout (Suziara in Japanese), J.
Oleo Science, 66, 579-584 (2017).
226) Yuki Inoue, Masamitsu Shimazawa, Ryota Nagano, Yoshiki Kuse, Kei Takahashi, Kazuhiro
Tsuruma, Masahiro Hayashi, Takashi Ishibashi, Takashi Maoka, Hideaki Hara, Astaxanthin analogs,
adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration,
Journal of Pharmacological Sciences 134, 147-157 (2017).
227) 成田正直、眞岡孝至、桒原泰裕、蝦谷幸司、オホーツク海に生息するアカボヤ
Halocynthia aurantium の一般成分とカロテノイド組成、日本水産学会誌、 82, 996-1004(2017).
228) Yuki Fukaya, Miho Takemura, Takashi Koyanagai, Takashi Maoka, Kazutoshi Shindo,
Norihiko, Misawa, Structural and functional analysis of the carotenoid biosynthesis genes of a
Pseudomonas strain isolated from the excrement of Autumn Darter, Biosci. Biotech. Biochem., 82,
1043-1052 (2018).
229) Wataru Aoi, Takashi Maoka, Ryo Abe, Mayuko Fujishita, Kumi Tominaga, Comparison of theeffect of non-esterified and esterified astaxanthins on endurance performance in mice J. Clin.
Biochem. Nutrition. 62, 161-166 (2018).
230) Masahiro Hayashi, Takashi Ishibashi, Takashi Maoka, Effect of astaxanthin-rich extract
derived from Paracoccus carotinifaciens on cognitive function in middle-aged and older individuals,
J. Clin. Biochem. Nutrition. 62, 195-205 (2018).
231) Takashi Ichikawa, Azusa Nishino, Takeshi Takaha, Takashi Kuriki, Hideko Nihei, Hiroyuiki
Yasui, Takashi Maoka, and Kazuhisa Kawamoto, Effect of paprika xanthophylls supplementation on
oxygen uptake in athletes: a randomized double-blind, placebo-controlled study, J. Phys. Fitness
Sports Med, 7, 247-252 (2018).
232) Ryo Kakutani, Saori Hokari, Azusa Nishino, Takashi Ichikawa, Kazuhisa Sigimoto, Takeshi
Takaha, Takashi Kuriki, and Takashi Maoka, Effect on oral paprika xanthophyll intake on
abdominal fat in healthy overweight humans: A randomized, double-brined, placebo-controlled
study. J. Oleo Science. 97, 1149-1162 (2018).
233) Takashi Maoka, New acetylemic carotenoid 6’-epimomadoxanthin from the rosary goby
Gymnogobius castaneus. J. Oleo Science. 97, 1259-1263 (2018).
234) Takashi Maoka, Yuki Kawashima, and Mikihiro Takaki. Structures of yellow xanthophylls andmetabolism of astaxanthin in the prawn Penaeus japonicus. J. Oleo Science. 97,1425-1433 (2018).
235) Jiro Koizumi, Naoki Takatani, Noritoki Kobayashi, Koji Mikami, Kazuo Miyashita, Yumiko
Yamano, Akimori Wada, Takashi Maoka, and Masashi Hosokawa, Carotenoid profiling of a redseaweed Pyripia yezoensis: Insights into biosynthetic pathways in the order Bangiales, Marin Drugs,
16, 426- (2018).
236) Azusa Nishino, Takashi Ichihara, Kazuhisa Sugimoto, Takashi Kuriki, Hiroyuki Yasui, andTakashi Maoka, Predicting organ carotenoids levels from analysis of plasma could lead to errors: A
study in cynomolgus monkeys. Nutrition Research, 61, 95-101 (2019).

18237) Ling Li, Maiko Furubayashi, Shifei Wang, Takashi Maoka, Shigeko Kawai-Noma, Kyoichi
Saito, Daisuke Umeno, Genetically engineered biosynthetic pathways for nonnatural C60
carotenoids using C5-elongases and C50-cyclases in Escherichia coli. Scientific Reports, (2019)
9:2982 https://doi.org/10.1038/s41598-019-39289-w
238) Shingo Ueno, Park Ryoyun, Yukio Tosa, Takashi Maoka, Naoto Kojima, Masayuki Yamashita,
Masafumi Inoue, and Tamio Ueno, Mosquito laevicidal and antifungal isoquinoline alkaloids from
Papaveraceae. Jpn. J. Environ. Enthomol. Zool. 30, 51-61 (2019).
239) Ling Li, Maiko Furubayashi, Yusuke Otani, Takashi Maoka, Norihiko Misawa, Shigeko
Kawai-Noma, Kyoichi Saito, and Daisuke Umeno, Nonnatural biosynthetic pathway for 2hydroxylated xanthophylls with C50-carotenoid backbone, J. Bioscience and Bioengineering, 128,438-444 (2019).
240) Miho Takemura1, Akiko Kubo, Yuki Higuchi1, Takashi Maoka, Takehiko Sahara, Katsuro
Yaoi, Kohji Ohdan, Daisuke Umeno, Norihiko Misawa, Pathway engineering for efficient
biosynthesis of violaxanthin in Escherichia coli, Applied Microbiology and Biotechnology, 103 (20327), 1-7 (2019)241）Masahiro Hayashi, Moe Kawamura, Yuki Kawashima, Takeshi Uemura and Takashi Maoka
Effect of astaxanthin-rich extract derived from Paracoccus carotinifaciens on the status of stress andsleep in adults, J. Clin. Biochem. Nutr. 66, 92-102 (2020).
242) Takashi Maoka, Naoki Kawase, Tetsuyuki Ueda, Ritsuo Nishida, Carotenoids of doragonflies,
from the perspective of comparative biochemical and chemical ecological studies, Biochem. Syst.
Ecol. 89 (2020) 104001. https://doi.org/10.1016/j.bse.2020.104001
243) Shun Tamaki, Yuri Tanno, Shota Kato, Kazunari Ozasa, Mayumi Wakazaki, Mayuko Sato,
Kiminori Toyooka, Takashi Maoka, Takahiro Ishikawa, Mizuo Maeda, Tomoko Shinomura,
Carotenoid accumulation in the eyespot apparatus required for phototaxis is independent ofchloroplast development in Euglena gracilis, Plant Science, 298, (2020) 110564
244) Shinsuke Nakamura1, Takashi Maoka, Yoshiki Kuse, Aomi Muramatsu,Yuta Yoshino,
Masamitsu Shimazawa, Hideaki Hara, Distribution of carotenoids and protective effects ofzeaxanthin on retina of Ayu sweet fish (Plecoglossus altivelis), J. Oleo Science 69, 1095-1105(2020).
245) Takashi Maoka, A new carotenoid, 5,6-dihydrocrustaxanthin, from prawns and the distributionof yellow xanthophylls in shrimps, Biochem. Syst. Ecol. 92 (2020). 104083
DOI:10.1016/j.bse.2020.104083
246) Takashi Maoka, Shinsuke Nakamura, Hideaki Hara, Carotenoids of land-locked and sea-run
types of masu salmon Oncorhynchus masou ishikawae inhabiting in the Nagara River, Japan, fromthe perspective of chemical ecological study, Biochemical Systematic and Ecology 93, 104181(2020).
247) Chiharu Takagi, Momoka Abe, Yumi Kaneko, Akane Sasaki, Ayumi Ito, Yuka Sakemi,
Takashi Maoka, Jürgen Breitenbach, Gerhard Sandmann, Kazutoshi Shindo, Structures of new C41
carotenoids produced using recombinant Escherichia coli expressing genes encoding isopentenyl
pyrophosphate,methyltransferase, and carotenoid biosynthetic enzymes, Tetrahedron Letters 61,
Issue 51 (2020) 152633.
248) Chiaki Ikeda, Yuki Manabe, Nami Tomonaga, Tatsuya Wada, Takashi Maoka, and Tatsuya
Sugawara, Evaluation of intestinal absorption of dietary halocynthiaxanthin, a carotenoid from sea

19squirt Halocynthia roretzi. Marin Drugs 2020, 16 (1) 588, https://doi.org/10.3390/md18120588 249) Shohei Tsuji, Shinsuke Nakamura, Takashi Maoka, Tetsuya Yamada, Takahiko Imai, Takuya
Ohba, Tomohiro Yako, Masahiro Hayashi, Ken Endo, Masanao Saio, Hideaki Hara, Masamitsu
Shimazawa,, Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma. Mar. Drugs
2020, 18(9), 474; https://doi.org/10.3390/md18090474.
250) S. Nakamura, T. Maoka. S. Tsuji, M. Hayashi, M. Shimazawa, and H. Hara, Central Nervous
System Migration of Astaxanthin and Adonixanthinm Following Their Oral Administration in
Cynomologus Monkeys. J. Nutrition Sci Vitaminol. 66, 488-494 (2020).
251) Aleksander V. Prazukin a, Yuri K. Firsov, Elena V. Gureeva, Sergey V. Kapranov, Svetlana N.
Zheleznova, Takashi Maoka, Mikhail V. Nekhoroshev, Biomass of green filamentous alga
Cladophora (Chlorophyta) from a hypersaline lake in Crimea as a prospective source of lutein andother pigments. Algal Research 54, (2021) 102195
252) Takashi Maoka, Naoki Kawase, Mantaro Hironaka, Ritsuo Nishida, Carotenoids of hemipteraninsects, from the perspective of chemo-systematic and chemical ecological studies, Biochemical
Systematic and Ecology 95, 104241 (2021). https://doi.org/10.1016/j.bse.2021.104241

253) Naokai Takatani, Fumikai Beppu, Yumiko Yamano, Takashi Maoka, Nasashi Hosokawa,Seco-type β-Apocarotenoid Generated by β-Carotene Oxidation Exerts Anti-inflammatory
Effects against Activated Macrophages. J. Oleo Science, 70, 549-558 (2010).
254) Maiko Furubayashi, Akiko Kubo, Miho Takemura, Yuko Otani, Takashi Maoka, Yoshinobu
Terada, Katsuro Yaoi, Kohji Ohdan, Norihiko Misawa, and Yasuo Mitani, Capsanthin Production in
Escherichia coli by Overexpression of Capsanthin/Capsorubin Synthase from Capsicum annuum, J.
Agric. Food. Chem. 69 (17) 5076-5085 (2021). doi: 10.1021/acs.jafc.1c00083.
255) Miho Takemura, Takashi Maoka, Takashi Koyanagi, Naoki Kawase; Ritsuo Nishida, Tsutomu
Tsuchida, Mantaro Hironaka, Tetsuyuki Ueda, Norihiko Misawa, Elucidation of the wholecarotenoid biosynthetic pathway of aphids at the gene level and arthropodal food chain involving
aphids and the red dragonfly. BMC Zoology (2021) 6:19 https://doi.org/10.1186/s40850-02100082-w

256) Hiroshi Kikugawa, Takuma Okaya, Takashi Maoka, Masayuki Miyazaki, Keita Murofushi,
Takanari Kato, Yoko Hirono-Hara, Masahiro Katumata, Shoichi Miyahara, and Kiyota Y. Hara,
Carotenoid nostoxanthin production by Sphingomonas sp. SG73 isolated from deep sea sediment.
Marin Drugs 2021. 19 (5) 274 https://doi.org/10.3390/md19050274
257) Motoyasu Otani1, Kosuke Kitayama, Hiroki Ishikuro, Jun-ichiro Hattan,Takashi Maoka,
Hisashi Harada, Yuko Shiotani, Akane Eguchi,Eiji Nitasaka, and Norihiko Misawa, Construction oftransgenic Ipomoea obscura that exhibits new reddish leaf and flower colors due to introduction ofβ-carotene ketolase and hydroxylase genes Plant Biotechnology 38, 219–226 (2021).
258) Maiko Furubayashi, Takashi Maoka, and Yasuo Mitani, Promiscuous activity of β-carotenehydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6-hydroxy-3keto-ε-ends. FEBS Letters 28 March 2022 https://doi.org/10.1002/1873-3468.14342
259) Naoki Takatani, Fumiaki Beppu, Yumiko Yamano, Takashi Maoka, Kazuo Miyashita, Masashi
Hosokawa. Preparation of Apoastaxanthinals and Evaluation of Their Anti-inflammatory Action
against Lipopolysaccharide-Stimulated Macrophages and Adipocytes. ACS Omega Manuscript No.:
ao-2022-01164c (10.1021/acsomega.2c01164).

20260) Ryo Asaka, Kazuki Oshima, Shinji Kawasaki, Takashi Maoka, Chisato Tode, Zheng-Yu WangOtomo, and Shinichi Takaich, Major carotenoids of Meiothermus ruber are deinoxanthin glucosideesters, not meiothermoxanthin glucoside esters, J. Natural Prod. 85, 2266-2273 (2020).
261) Takashi Maoka and Chisato Tode, A novel carotenoid with a unique 2,6-cyclo--end group,
roretziaxanthin, from the sea squirt Halocynthia roretzi. Marine Drugs. 2022 732, 20, 732.
https://doi.org/10.3390/ md20120732.

262) Naoki Takatani, Kana Sakimura, Kodai Nagata, Fumiaki Beppu, Yumiko Yamano, Takashi
Maoka, Masashi Hosokawa, Identification and tissue distribution of fucoxanthinol andamarouciaxanthin A fatty acid esters in fucoxanthin-fed mice, Food Chemistry, 410 135318 (2023)
https://doi.org/10.1016/j.foodchem.2022.135318
263) Jun-ichiro Hattan, Maiko Furubayashi, Takashi Maoka, Miho Takemura, Norihiko Misawa,
Reconstruction of the Native Biosynthetic System of Carotenoids in E. coli Biosynthesis of a SeriesofCarotenoids
Specific
toPaprika
Fruit,ACS
Synthetic
Biology,https://pubs.acs.org/articlesonrequest/AOR-C5IIUDTGRZ9JIKSFFNDU
264) Yoshie Uchida, Takashi Maoka, Tanapat Palaga, Masaki Honda, Chisato Tode, Motoyuki
Shimizu, Rungaroon Waditee-Sirisattha, Hakuto Kageyama, Identification of desiccation stressinducible antioxidative and antiglycative ultraviolet-absorbing oxylipins, saclipin A and saclipin B,
in an edible cyanobacterium Aphanothece sacrum, J. Agric. Food Chem., 31, 16137-16147 (2023).
Manuscript ID: jf-2023-05152b.R2265) Shinji Kawasaki, Takayuki Kaneko, Tomomi Asano, Takashi Maoka, Shinichi Takaichi,
Yasuhito Shomura. 2023. An ependymin-related blue carotenoprotein decorates marine blue sponge.
Journal of Biological Chemistry 299(9), 105110. DOI:/10.1016/j.jbc.2023.105110
プロシーデイング1) 眞岡孝至、持田晃一、伊藤義弘, 光合成バクテリア Rhodobacter capusulatus の産生するカロテノイドの抗酸化作用, 医学と生物学, 128(3), 149-153 (1994).
2) 眞岡孝至、伊藤義弘, -カロテンとクエルシトリンの相乗的抗酸化作用, 医学と生物学,
129(2), 69-73 (1994).
3) 眞岡孝至、持田晃一、伊藤義弘,(1995).

ワムシ類のカロテノイド,

医学と生物学, 139(1), 1-34) 眞岡孝至、三宅一司、伊藤義弘,
学, 130(6), 193-195 (1995).

グロー放電による脂質過酸化抑制作用, 医学と生物

5) 日野宏一郎、山口茂治、伊田喜光、佐藤陽子、小塚睦夫、徳田春邦、 眞岡孝至、伊藤義弘,
黄柏のエプスタインバールウイルス活性化抑制作用, 医学と生物学, 131(1), 1-4 (1995).
6) 日野宏一郎、山口茂治、伊田喜光、佐藤陽子、眞岡孝至、伊藤義弘,
用, 医学と生物学, 131(2), 59-62 (1995).
7) 眞岡孝至、伊藤義弘、金村聖志、岡黄柏の抗酸化作

茂範、三宅一司、桜井 弘, グロー放電素子を用21いるDPPHラジカルの消去作用, 磁気共鳴と医学 7, 62-65 (1996).
8) 眞岡孝至、伊藤義弘、金村聖志、岡 茂範、日野唯行、川西伸也、三宅一司、 桜井弘,
容量結合型グロー放電を用いるラジカル反応, 磁気共鳴と医学, 8, 97-100 (1997).
9) Amelia P. Guevara, Carolyn Vagas, Hiromu Sakurai, Keiji Hashimoto, Yasuhiro Fujiwara andTakashi Maoka, A new rhamnosyl carbamate from the seeds of Moringa olefera LAM., ACGC
Chemical Research Communications, 10, 48-51 (2000).
10) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto and Naoshige Akimoto, Isolation of aseries of apocarotenoids from the fruits of the red paprika Capsicum annuum L. Carotenoid Science,
4, 91-92 (2001).
11) Naoshige Akimoto, Takashi Maoka, Yasuhiro Fujiwara and Keiji Hashimoto, Characterizationof epoxy carotenoids by FAB CID-MS/MS, Carotenoid Science, 4, 93-94 (2001).
12) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto and Naoshige Akimoto, Apocarotenoids
from lily Lilium lancifolium, Carotenoid Science, 5, 19-20 (2002).
13) Yoshiko Satomi, Norihiko Misawa, Takashi Maoka, and Hoyoku Nishino, Production ofphytoene, an anti-tumor promoting carotenoids, in mice by introducing a phytoene synthase gene
crtB, Carotenoid Science, 5, 26-27 (2002).
14) Shinichi Takaichi, Philipp Krubasik, Takashi Maoka, Kazumori Masamoto, and Gerhard
Sandmann, Detailed biosynthetic pathway to decaprenoxanthin diglucoside in Corynebacterium
glutamicum and identification of novel intermediates, Carotenoid Science, 5, 34-35 (2002).
15) Shinich Takaichi, Norihiko Misawa, Masayoshi Ito, Yumiko Yamano, Takashi Maoka, andAkihiro Yokoyama, LIPID Bank for web, a newly developed lipid database in Japan: Carotenoid Class,
Carotenoid Science, 5, 44-51 (2002).
16) Hiroaki Inoue, Akira Tateishi, Yoshiko Kimura, Yuko Ozawa, Katunori Inoue, Kazunari
Nomura, Takashi Maoka, Hideki Hashimoto, Jieping Shi, Kunxia Zhao, and Saishi Hirata, Contents
and compositions of chlorophylls, carotenoids, vitamin C, vitamin E, and minerals in deep color andlight color vegetable crops and their correlation, Carotenoid Science, 6, 5-8 (2003).
17) Miyuki Tsushima, Takashi Maoka, and Hoyoku Nishino, Isolation and characterization of
dinochromes A and B, Anti-carcinogenic active carotenoids from the fresh water red tide Peridinium
bipes, Carotenoid Science, 6, 38-39 (2003).
18) Fumio Enjo, Takashi Maoka, Harukuni Tokuda, Masashi Kuchide, Masakazu Ogata, Teruo
Mukainaka, Junko Takayasu and Hoyoku Nishino Regulation of the cycle progression of A-549
human lung cancer cell treatment by paprika carotenoids, capsanthin and capsorubin, Carotenoid
Science, 7, 49-50 (2004).
19) Saishi Hirota, Tetuya Arinobu, Zhao Kunxia, Shi Jiping, Luo Yunbo, Cui Yulin, Takashi Maoka
and Michiaki Murakoshi, Studies of cis-trans carotenoids in red, yellow and tangerine strains oftomato and their biosynthetic considerations, Carotenoid Science, 8, 1-5 (2005).
20) Sanae Kishimoto, Takashi Maoka, Katsuhiko Aumitomo, Masayoshi Nakayama and Akemi
Ohmiya, Carotenoid composition in petals of two Compositate plants, chrysanthemum(Dendranthema grandiflorum (Ramat.) Kitamura) and calendula (Calendula officinalis L.),
Carotenoid Science, 8, 6-8 (2005).

2221) Takashi Maoka and Naoshige Akimoto, Combined HPLC and FAB MS/MS for analysis ofnatural carotenoids, Carotenoid Science, 8, 11-13 (2005).
22) Fumio Enjo, Takashi Maoka, Kooichi Mochida, Harukuni Tokuda and Hoyoku Nishino, Growth
inhibitory effect of capsorubin and -carotene in prostatic cancer cell line, Carotenoid Science, 8,75-76 (2005).
23) Takashi Maoka, Shinichi Ito and Takashi Wada, Analysis of carotenoids in Japanese humanserum by Using HPLC with photodiode array detection, Carotenoid Science, 8, 81-83 (2005).
24) Takashi Moka, Kumi Hidaka, Atsuko Nkakajima, Fumio Tanimoto, Mitsuhiko Sano, Kanji
Tsurukawa, Takuo Tsuno, Satomi Tsujiwaki and Keiji Takii, Improvement of the integumentarycolor and suppression of oxidative stress for cultured red sea bream by ferulic acid and -orizanol,
Carotenoid Science, 8, 84-86 (2005).
25) Takashi Maoka, Yasuhiro Fujiwara, Keiji Hashimoto, and Naoshige Akimoto, Carotenoids incorbicula clams, Corbicula japonica, Corbicula sandai, and Chinese corbicula clam, Carotenoid
Science, 10, 81-84 (2006).
26) 滝井健二、石丸克也、吉田幸助、井上修一、日高久美、眞岡孝至、谷本文男、伏木省
三、アユ用配合飼料への自己消化酵母 Hansenula anomala の利用、近畿大学水産研究所報告、10､ 11-18 (2006).
27) Takashi Maoka and Naoshige Akimoto, Fucoxanthin and fucoxanthinol ester in clam,
Carotenoid Science, 11, 6-9 (2006).
28) Koji Ishiguro, Masaru Yoshinaga, Makoto Yoshimoto, Naoshige Akimoto, and Takashi Maoka,
Structures of new carotenoids with 5,6-didehydro-5,6-dihydro-β-end group, named ipomoeaxanthin
A, B, C1 and C2 from yellow sweetpotato “Benimasari”, Ipomoea batatas L., Carotenoid Science,
11, 64-67 (2007).
29) Takashi Maoka and Naoshige Akimoto, Isolation of a new 2-hydroxy carotenoids, 2,3’dihydroxycanthaxanthin from the hermit crab, Paralithodes brevipes, Carotenoid Science, 11, 68-70(2007).
30) Takashi Moaka, Kooichi Mochida, Fumio Enjo, Harukuni Tokuda, Hoyoku Nishino, Growth
inhibitory effects of paprika carotenoids, capsorubin for human cancer cells, J. Clin. Biochem. Nutr.,
43 Supple. 1, 281-284 (2008).
31) Takashi Maoka and Naoshige Akimoto, Natural Product Chemistry in carotenoid someexperimental techniques for structural elucidation and analysis of natural carotenoids,
Carotenoid Science, 13, 10-17 (2008).
32) Takashi Maoka, Naoshige Akimoto, Keiji Hashimoto, Yasuhiro Fujiwara, Isolation andcharacterization of pittosporumxanthins 3’-esters from the seeds of Pittosporum tobira, Carotenoid
Science, 13, 18-19 (2008).
33) Chisato Tode, Takashi Maoka, and Makiko Sugiura, The DOSY measurement of the extract
lipid including carotenoids from marine products –Part 1- Carotenoid Science, 13, 31-32 (2008).
34) Takashi Maoka, Structural studies of natural carotenoids by our research group during the three
decade, Carotenoid Science, 14, 26-36 (2009).

2335) Takashi Nakajima, Takashi Wada, Naoko Tarui, Shin-ichi Ito, Yoshizoh Yuasa, and Takashi
Maoka, Analysis of carotenoids in human serum and erythrocyte by ultra performance liquid
chromatography (UPLC) , Carotenoid Science, 14, 46-49 (2009).
36) Takashi Maoka, Makoto Tsuboi, Aditya Kulkarini, Yukimasa Terada, Kyuki Kato, Hiroki
Nakatsugawa, Hironobu Mori, Takahiro Inakuma, and Hideo Etoh, Nitrocarotenoid andoxazinecarotenoid, Reaction products of carotenoids with peroxynitrite, Carotenoid Science, 15, 613 (2010).
37) Takashi Maoka, Masanao Narita, and Hoyoku Nishino, Identification of red pigment in the red
adductor muscle of Japanese Scallop (Mizuhopecten yessoensis), Carotenoid Science, 15, 18-20(2010).
38) Shinzo Hosoi, Yukiteru Katsumoto, Takeyuki Tanaka, Takashi Maoka, Toshio Fujiwara, andManabu Node, CD spectra of (4R)-β-isocryptoxanthin and its benzoate: A quantum chemical
approach for estimation of the absolute configuration, Carotenoid Science, 15, 39-43 (2010).
39) Chisato Tode, Takashi Maoka, and Makiko Sugiura, Analysis of carotenoid component in foodusing LC-NMR-part1-, Carotenoid Science, 15, 49-50 (2010).
40）眞岡孝至 アンチエイジングを目指した水産物の利用 水産物由来アンチエイジング
素材、カロテノイドとその利用、日本水産学会誌、77、262（2011）.
41) Takashi Maoka, Naoshige Akimoto, Sadao Komemushi, Yoshimitsau Takahashi, Ryo Harada,
Naomi Sameshima, Miho Mori. And Yoshikazu Sakagami, Carotenoids in corals and crown-ofthorns starfish-From the perspective of the food chain of marine animals- Carotenoid Science, 16, 15 (2011).
42) Takahiro Wakahama, Hidetoshi Okuyama, Takashi Maoka, and Shinichi Takaichi, Uniquecarotenoid lactoside, P457, in Symbiodinium sp. of dinoflagellate, Acta Biochimica Polonica, 59,
155-157 (2012).
43) Hideo Etoh, Yasunori Maejima, Yukari Imaeda, Satomi Sugiyama, Shinji Tokuyama, Hideaki
Kato, Aditya Kulkarni, and Takashi Maoka, Extraction of Astaxanthin by Sub-Critical Water fromthe Green Algae Haematococcus pluvialis Carotenoid Science 17, 13-15 (2012).
44) Takashi Maoka and Naoshige Akimoto, ε-Cryptoxanthin, the First Report of ε,ε-Carotene-monool, from the Japanese Common Catfish, Silurus asotus, Carotenoid Science 17, 46-47 (2012).
45) Takashi Maoka, Tetsuji Etoh, Naoshige Akimoto, Harukuni Tokuda, Nobutaka Suzuki, andHiroyuki Yasui, Carotenoid Pyropheophorbide A Esters from Abalones, Haliotis diversicolor
aquatilis and Haliotis discus, Carotenoid Science 17, 48-51 (2012).
46) Ayako Osawa, Yoko Ishii, Asami Kasahara, Nao Sasamura, Shoko Mastuoka, Marie Morita,
Hiroaki Kasai, Takashi Maoka, Gerhard Sandmann, and Kazutoshi Shindo, Antioxidative
Carotenoids from Bacteria, Carotenoid Science 17, 52-54 (2012).
47) Takashi Maoka, Takashi Kuwahara, and Masanao Narita, Carotenoids of nymph of sea ice,
Clione, Proceedings of the 28th international symposium on Okhotsk sea&ice, 31-33 (2013).
48) Yuki Kawashima, Hideaki Nagai, Michihisa Ikarashi, Takashi Maoka, Development ofPanaferd-ZX: Zeaxanthin enriched dry cell using Praracoccus carotenifacience, Carotenoid Science,
18, 110 (2014).

2448) Takashi Maoka and Wataru Miki, Micro-scale analysis of carotenoids using LC/MS method,
Carotenoid Science 19, 1-6 (2014).
49) Takashi Maoka and Tetsuji Etho, Identification of capsanthone, an oxidative metabolite ofcapsanthin in hen’s egg yolk, Carotenoid Science 19, 17-20 (2014).
50) Toru Okada, Takashi Maoka, Mineto Tani, Chikako Tani, Yasuo Moritomo, Go Kitahara,
Hiromu Katamoto, Accumulation of xanthophylls from the phaffia yeast (xanthophyllomyces
dendrorhrous) in cattle, Carotenoid Science 19, 24-27 (2014).
51) Takashi Maoka, Takashi Kuwahara, Masanao Narita, Carotenoids of sea angels, Carotenoid
Science, 19, 33-37 (2014).
52) Fumio Sato, Eiji Yamashita, and Takashi Maoka, Absorption pf orally adominsteres astaxanthin
in horse, Carotenoid Science, 20, 40--41 (2015).
53) Takashi Maoka, Yukiko Yamano, and Akimori Wada, Distribution of stereoisomers ofalloxanthin in aquatic animals, Carotenoid Science, 20, 42-45 (2015).
54) Takashi Moka, Tetsuji Etho, Yumiko Yamano, and Akimori Wada, Isolation andcharacterization of lycopene-5,6-diols and γ-carotene-5’,8’-diols from gac (Momordica
cochinchinensis), Carotenoid Science, 20, 46-50 (2015).
55) Takashi Maoka, Carotenoids of insects, grasshoppers, crickets, mantises, and stick insects,
Carotenoid Science, 20, 51-54 (2015).
56) Miho Takemura, Takashi Maoka, and Norihiko Misawa, Evolution of carotenoid biosynthesis
genes in land plants: from the viewpoint of liverwort, Carotenoid Science, 20, 55-58 (2015).
57) Takashi Maoka, History of Carotenoid Research in Japan Before 1990, Carotenoid Science, 21,
5-8 (2016).
58) Takashi Maoka, Azusa Nishino, Hiroyuki Yasui, Yumiko Yamano, and Akimori Wada, Marine
Carotenoid Mytiloxanthin, a Metabolite of Fucoxanthin in Shellfish and Tunicates, Carotenoid
Science, 21, 20-27 (2016).
59) Takasi Maoka, Syu Nakachi, Ryouhei Kobayashi, Miho Mori, and Yoshikazu Sakagami,
Carotenoids in the sea cucumber Plesiocolochirus minutus belonging to Cucumariidae(dendrochirotida), Carotenoid Science, 21, 28-31 (2016).
60) Motoko Fukuda, Takashi Ishibashi, and Takashi Maoka, Analysis of Adonixanthin andAdonirubin in Human Serum by Ultra Performance Liquid Chromatography (UPLC)-MS/MS,
Carotenoid Science, 21, 42-46 (2016).
61) Takashi Maoka, Miyuki Tsushima, and Hiroyuki Yasui, History of carotenoid research in Kyoto
Pharmaceutical University, Carotenoid Science, 22, 6-8 (2017).
62) Chikako Tani, Mineto Tani, Yasuo Moritomo, Go Kitahara, Takeshi Osawa, Hiromu Katamoto,
Toru Okada, and Takashi Maoka, Comparison of carotenoid content (β-carotene and lutein) in the
blood and follicular fluid of Japanese barown cattle during and after the grazing period, Carotenoid
Science, 22, 23-28 (2017).
63) Takashi Maoka, A new acetylemic carotenoid 6’-epimonadoxanthin from the Rosary Goby

25

Gymnogobius castaneus, Carotenoid Science, 22, 42-44 (2017).
64) Hayato Maeda, Shohei Mikami, Saori Hokari, Azusan, Nishino, Takeshi Takaha, and Takashi
Maoka, Effect of paprika xanthophyll on chronic inflammation in adipocyte, Carotenoid Science, 22,45-46 (2017).
65) Massano Narita, Takashi Maoka, Yasuhiro Kuwahara, and Kohji Ebitani, Seasonal variation in
the proximate composition and carotenoid profile of Halocynthia austrantium in the Okhotsk Sea,
Carotenoid Science, 22, 47-53 (2017).
66) Takashi Maoka, Yuki Kawashima, and Mikihiro Takagi, Yellow carotenoids, as metabolites ofastaxanthin, in the prawn Penaeus japonicus, Carotenoid Science, 22, 61-63 (2017).
67) Shota Seto, Tomoko Horibe, Chiasa Uragami, Yuko Sugai, Takashi Maoka, Taenori Nishioka,
and Hodeki Hashimoto, Isolation and purification of capsanthin from red paprika (Capsium annuumL.) and its application to the stark spectroscopic measurements, Carotenoid Science, 22, 76-79(2017).
68) Takashi Maoka, The possible mechanisms of the chiral conversion of astaxanathin un the prawn.
Carotenoid Science, 23, 15-18 (2019).
69) Shota Watanabe, Toru Okada, Hideo Ookita, Kyoichi Sakamoto, Kengo Suzuki, Takashi Maoka,
Accumulation of the euglena-derived carotenoids in egg yolk. Carotenoid Science, 23, 19-23 (2019).
70) Keisuke Kawakami, Takashi Maoka, Yuhei O Thahara, Junko Shiomi, Makoto Miyata, Nobuo
Kamiya, Daisuke Kosumi, Photosynthetic megacomplexes by a novel sample preparation method
and identification of carotenoids interesting with photosystem II from Thermosynechoccus vulcanus.
Carotenoid Science, 23, 41-44 (2019).
71) Azusa Nishino, Takahashi Ichihara, Kazuhisa Kawamoto, Takashi Maoka, Detailed
chromatographic and spectral data of capsanthone in paprika intake human plasma and erythrocytes.
Carotenoid Science, 23, 50-53 (2019).
72) Keisuke Kawakami, Yuma Hirota, Yuhei Tahara, Junko Shimomi, Takashi Maoka, Susumu
Takio, Makoto Miyata, Nobuo Kamiya, Daisuke Kosumi, Towards elucidation of light energy
transfer mechanism of the photosynthetic supercomplexes from algae, Carotenoid Science, 23, 57-58(2019).
73) Wataru Matsumoto, Haruka Nanaura, Miho Takemura, Takashi Maoka, Norihiko Misawa,
Isolation and functional analysis of carotenoid biosynthesis genes from human gut and probiotic
bacteria, Carotenoid Science, 23, 69-70 (2019).
74) Takashi Maoka, Naoki Kawase, Origin of carotenoids in dragonfly. Carotenoid Science, 23, 75(2019).
75) Takashi Maoka, Yuki Kawashima, Mikihiro Takagi, Structure of yellow xanthophylls andmetabolism of chiral conversion of hydroxy group in astaxanthin in the prawn. Carotenoid Science,
23, 76 (2019).
76) Takashi Maoka, Structures of carotenoids determined by our research group during 2009 to 2019,
Carotenoid Science, 24, 12-18 (2020).
77) Chisato Tode, Takashi Maoka, and Atsuko Takeuch, Application pf DOSY experiment toanalysis of astaxanthin and it’s analogues, Carotenoid Science, 24, 24.-34 (2020).

2678) Takashi Maoka, Structural dterrmination of a minor yellow carotenoid, 5,6dihydropirardixanthin from the prawns Penaeus japonicus and P. vannamei, Carotenoid Science, 24,
41-43 (2020).
79) Miyuki Tsushima and Takashi Maoka, In memory of Professor Emeritus Yakao Matsuno,
Carotenoid Science, 26, 1-3 (2023).
80) Miho Takemura, Takashi Maoka, and Norihiko Misawa, Bioproduction of carotenoids using
Escherichia coli, Miho Takemura, Takashi Maoka, and Norihiko Misawa, Carotenoid Science, 26,
14-19 (2023).
81) Functional expression of the astaxanthin biosynthesis genes in Fressia hybrida, Yohei Uwagaki,
Motoyasu Otani, Masako Komaki, Minoru Murahara, Miho Takemuram Takashi Maoka, andNodihiko Misawa, Carotenoid Science, 26, 26-32 (2023).
82) Takashi Maoka, Total NMR assignment of mytiloxanthinone, a characteristic carotenoid of sea
squirt, Carotenoid Science, 26, 71-73 (2023).
プロシーデイング （天然有機化合物討論会要旨）

1) 眞岡孝至、松野隆男、藤原靖弘, 第３５回天然有機化合物討論会（京都）要旨集 401407 (1993).
2) 眞岡孝至、秋元直茂、橋本圭二、黒田義弘、藤原靖弘, トベラ種子の新規カロテノイド
pittosporumxanthins B1, B2, C1, C2 のMS/MS 法を用いた構造研究 , 第３７回天然有機化合物討論会（徳島）要旨集 373-378 (1995)
3) 眞岡孝至、橋本圭二、真鍋潔司、藤原靖弘 , トベラ種子の新規赤色カロテノイド
tobiraxanthin の構造研究 , 第３９回天然有機化合物討論会（札幌）要旨集 487-492 (1997).
4) 藤原靖弘,橋本圭二、秋元直茂、眞岡孝至, マガキ(Crassostrea gigas)の新規カロテノイドの構造研究, 第４１回天然有機化合物討論会（名古屋）要旨集 541-546 (1999).
5) 眞岡孝至、秋元直茂、藤原靖弘、橋本圭二、パプリカ （Capsicum annuum L.） の新規
カロテノイドのMS/MSを用いた構造研究、 第４５回天然有機化合物討論会（京都）要旨
集 611-616 (2003).
6）細井信造、勝本之晶、田中丈幸、眞岡孝至、野出學、(4R)-β-Ioscryptoxanthin 及びそのベンゾエ―ト体の CD スペクトル：量子化学的アプローチによるカロテノイドの絶対配置推定について、第５１回天然有機化合物討論会(名古屋)要旨集 479-484（2009）7)衛藤英男、眞岡孝至、加藤久喜、中津川広樹、坪井 誠、寺田幸正、松本 岳、森 啓信、
細川雅史、宮下和夫カロテノイドによる活性窒素種消去の検討－カロテノイドとペルオキ
シナイトライトの反応物について、第５２回天然有機化合物討論会(静岡)要旨集 499-504（2010）
8) 竹村美保、眞岡孝至、徳田春邦、鈴木信孝、三沢典彦, 細菌Pantoea ananatisとゼニゴケ

27

Marchantia polymorpha のカロテノイド生合成遺伝子の組み合わせによる大腸菌での機能性
カロテノイドの生産、第５５回天然有機化合物討論会(京都)要旨集 615-620（2013）.

総説 (Review)1) 眞岡孝至、高速液体クロマトグラフィーによるカロテノイド立体異性体の分離、Jasco
Report, 34, 59-61 (1992).
2) 伊藤義弘、眞岡孝至, ドクダミと -カロチンの相乗的抗酸化作用, バイオインダストリ
ー 12 (9), 14-23 (1995).
3) Takashi Maoka, Analysis of carotenoids by combined HPLC, UV-Vis and APCI-MS, Lipid
Technology, 15, 39-42 (2003).
4) 眞岡孝至、秋元直茂、橋本圭二 、HPLC, UV-Vis, MSを組み合わせた天然カロテノイドのオンライン分析、FFI JOURNAL, 208, 623-630 (2003).
5) 眞岡孝至、圓城文雄、徳田春邦、西野輔翼、パプリカ (Capsicum annuum L.) カロテノ
イドの発がん予防効果を中心とした生理作用、 FFI JOURNAL, 209, 203-210 (2004).
6) 眞岡孝至、カロテノイドの多様な生理作用、食品・臨症栄養、2, 3-14 (2007).
7）眞岡孝至、カロテノイドと健康‐その多様な生理作用‐環境と健康、20, 318-328(2007).
8) Valery M. Dembitsky and Takashi Maoka, Allenic and cumulenic lipids, Progress in Lipid
Research, 46, 328-375 (2007).
9) Takashi Maoka, Recent progress in structural studies of carotenoids in animals and plants, Archiv.
Biochem. Biophys., 483, 191-195 (2009).
10）眞岡孝至、カロテノイド－天然色素の役割とその機能－ Functional Food, 12号, Vol. 4,
182-188 (2010).の多様な生理作用、食品・臨症栄養、2, 3-14 (2007).
11）眞岡孝至、カロテノイド－天然色素の役割とその機能 カロテノイドの概説と歴史、
最近の注目点、Functional Food, 12, (Vol. 4 No. 2) 182-188 (2010).
12) Takashi Maoka, Carotenoids in marine animals, Mar. Drugs 9, 278-293 (2011).
13）眞岡孝至、カロテノイド－天然における分布とその役割、Food Reserch､2011,3､21-25(2011).
14) 眞岡孝至、安井裕之、カプサンチン、Functional Food, 16, (Vol. 5 No. 2) 177-182 (2011).
15）眞岡孝至、天然カロテノイドの分析と構造研究、オレオサイエンス、 12, 485-494(2012).
16) 衛藤英男、眞岡孝至、リコペンとがん予防、Functional Food, 20, (Vol. 6 No. 2) 115-120(2012).

2817）眞岡孝至 食品と疾病－カロテン 構造と分布、Functional Food, 21, (Vol. 6 No. 3) 150155 (2013).
18) 眞岡孝至 概論：フコキサンチン-その化学構造の特徴、天然における分布と代謝
Functional Food, 6, 220-225 (2013).
19) 眞岡孝至(2014).

カロテノイド-天然色素とその役割

ENEOS Techinical Review, 56, 88-95

20) 眞岡孝至、日本におけるカロテノイド研究 その歴史と現状、FFI JOURNAL, 220, 99100 (2015).
21) 眞岡孝至、天然カロテノイドの多様性とその役割、FFI JOURNAL, 220, 118-124 (2015).
22）眞岡孝至、自然を彩るカロテノイドの世界 カロテノイドの分析と構造解析 (1), Food
Style 21, 21, (No. 8), 46-52 (2017).
23) 眞岡孝至、自然を彩るカロテノイドの世界 カロテノイドの分析と構造解析 (2), Food
Style 21, 21, (No. 9), 34-39 (2017).
24）西野梓、市原敬司、安井裕之、眞岡孝至、パプリカカロテノイドの血中動態と抗酸化機構の解析、オレオサイエンス、18, 91-97 (2018).
25) 眞岡孝至
100 (2018).

カロテノイド研究40年 ―天然色素に魅せられて―科学・技術研究, 7, 93-26）Takashi Maoka Carotenoids as natural functional pigments, J. Natural Medicines. 74, 1-16
(2020). DOI 10.1007/s11418-019-01364-x (2019).
27）眞岡孝至, 天然色素カロテノイドの生理機能 その１、医と食、12, 76-80 (2020).
28) 眞岡孝至, 天然色素カロテノイドの生理機能 その２、医と食、12, 138-143 (2020).
29) 眞岡孝至、カロテノイドの機構研究と応用開発、月刊
13-21 (2020).

ファインケミカル、49, No. 7,30) Azusa Nishino, Takashi Maoka, and Hiroyuli Yasui, Preventive Effects of β-Cryptoxanthin, aPotent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases—A Central Focus
on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD) Antioxidants 2022, 11(1), 43;
https://doi.org/10.3390/antiox11010043 (registering DOI)..
31) Norihiko Misawa, Takashi Maoka , and Miho Takemura, Carotenoids: Carotenoid andapocarotenoid analysis—Use of E. coli to produce carotenoid standards. Pp87-137Methods in
Enzymology Vol 670 Edited by Eleanore T. Wurtzel Academic Press Elsevier 2022
https://authors.elsevier.com/a/1eymzHRzCMNJC
32) 眞岡孝至 天然カロテノイドの多様性とその役割、食品加工技術、42, 31-38 (2022).
33) Yasuhiro Nishida, Pernilla Christina Berg, Behnaz Shakersain, Karen Hecht, Akiko Takikawa,Ruohan Tao, Yumeka Kakuta, Chiasa Uragami, Hideki Hashimoto, Norihiko Misawa, and Takashi
Maoka, Astaxanthin: Past, Present, and Future, Mar. Drugs 2023, 21, 514.

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https://doi.org/10.3390/md21100514
34) Takashi Maoka, Carotenoids: Distribution, Function in Nature, and Analysis Using LCPhotodiode Array Detector (DAD)-MS and MS/MS System, Mass Spectrometry DOI:
10.5702/massspectrometry.A0133
著書
1) 伊藤義弘、眞岡孝至, ドクダミと -カロチンの相乗的抗酸化作用,
機能 シーエムシー pp. 94-104、 東京、1997.

新しい食品素材と

2) Mari Mochimaru, Hajime Masukawa, Takashi Maoka, and Shinichi Takaichi, Functional
identification of GDP-fucose synthase gene in Anabaena sp. PCC 7120. J.F. Allen, E. Gantt,
J.H. Golbeck, and B. Osmond (Eds.) Phtosynthesis. Energy from the Sun PP. 331-334. Springer,2008.
3) 眞岡孝至、第1章 カロテノイドの構造と生物界における分布、カロテノイドの科学と最新応用技術、宮下和夫編、pp. 3-14、シーエムシー、東京、2009.
4) 眞岡孝至、第2章 カロテノイドの分析と構造研究、カロテノイドの科学と最新応用技術、宮下和夫編、pp. 15-26、シーエムシー、東京、2009.
5) 眞岡孝至、第２章 アスタキサンチンとは、アスタキサンチンの科学、矢澤一良編、pp.11-27、成山堂書店、東京、2009．
6) Takashi Maoka and Hideo Etoh, Some biological functions of carotenoids in Japanese food, inFunctional Foods of the East John Shi, Chi-Tang Ho, Fereidoon Shahidi eds. CRC Press Boca
Raton, pp. 85-97. 2010.
7) 眞岡孝至、カロテノイドとその利用、アンチエイジングをめざした水産物の利用、水産学シリーズ171、平田孝、菅原達也編、pp. 97-111,恒星社厚生閣、東京、2011.
8) 眞岡孝至、アスタキサンチンの化学、アスタキサンチンの機能と応用、吉川敏一、内藤祐二監修、pp. 37-47、シーエムシー、東京、2012.
9) Takashi Maoka and Hideo Etoh, Biological Antioxidation Mechanism: Quenching ofPeroxynitrite, in Japanese food, in Functional Food Ingredients and Nutraceuticals Processing
Technologies (2nd Ed) John Shi ed. CRC Press Boca Raton, pp. 589-607. 2016.
10) Takashi Maoka, Structural studies of carotenoids in plants, animals, and food products, in
Carotenoids Nutrition, Analysis and Technology, Edited by Agnieska Kaczor and Malgorzata
Baranska, Wiley Blackwell, UK, pp .103-129, 2016.
11) 眞岡孝至、小暮健太郎、アスタキサンチン、寺尾啓二監修、食品成分の安定化技術、
シーエムシー出版、東京、2016、pp. 195-205.
12) Takashi Maoka, Carotenoid Metabolism in Aquatic Animaqls, in Carotenoids: Biosynthetic and
Biofunctional Approaches, Edited by Norihiko Misawa, Springer, Singapore, pp. 29-50, 2021.
13) Takashi Maoka, Carotenoid Metabolism in Terrestrial Animals, in Carotenoids: Biosynthetic
and Biofunctional Approaches, Edited by Norihiko Misawa, Springer, Singapore, pp. 51-66,30

2021.
14) Takashi Koyanagi, Takashi Maoka, and Norihiko Misawa, Fecal Microflora from Dragonflies
and Its Microorganisms Producing Carotenoids, in Carotenoids: Biosynthetic and Biofunctional
Approaches, Edited by Norihiko Misawa, Springer, Singapore, pp .209-216, 2021.
15) Norihiko Misawa, Miho Takemura , and Takashi Maoka, Carotenoid Biosynthesis in Animals:
Case of Arthropods, in Carotenoids: Biosynthetic and Biofunctional Approaches, Edited by
Norihiko Misawa, Springer, Singapore, pp .217-220, 2021.
16) Hayato Maeda, Azusa Nishino, and Takashi Maoka Biological Activities of Paprika
Carotenoids, Capsanthin and Capsorubim, in Carotenoids: Biosynthetic and Biofunctional
Approaches, Edited by Norihiko Misawa, Springer, Singapore, pp .285-293, 2021.
17) 日本ビタミン学会 編集 ビタミン・バイオファクター総合辞典
ノイド 構造。化学 pp293-295 朝倉書店 2021.

眞岡孝至

カロテ

18) 眞岡孝至、第２章 動物におけるカロテノイドの分布－食物連鎖、代謝、機能 カロ
テノイドの科学 －基礎、研究の新展開、生理活性－高市真一 監修、pp. 17-33、シーエムシー、東京、2024.

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