International Conference on the Biological Roles of
Polyamines 2024, 7th Yamada Symposium
Hotel Ariston and Kobe Chamber of Commerce Industry Hall,
Japan

August 25th to 30th, 2024

SCIENTIFIC PROGRAM

Scientific Advisory Board
Enzo Agostinelli
Susan Gilmour
Kazuei Igarashi
Annette Kaiser
Keiko Kashiwagi
Senya Matsufuji
Anthony Michael
Takami Oka
Tairo Ohshima
Otto Phanstiel
Stephan Sigrist
Taku Takahashi
Leah Vardy
Keith T. Wilson

Local Committee
Shinsuke Fujiwara
Kyohei Higashi
Yuri Ishii
Shin Kurihara
Noriyuki Murai
Kazuhiro Nishimura
Takeshi Uemura

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TOILET

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CONFERENCE ROOM 2CONFERENCE ROOM 1

ELEVATOR HALLATRIUMCLOAK

SHINSHO HALLY HALLELEVATOR HALLTOILET

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KOBE CHAMBE OF COMME CE IND

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ELEVATORHall

Valencia
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Valencia

Quality
Ariston
Hotel
Hotel
KOBE
KOBE
banquet-5-

SIZE OF POSTER BOARD (A0 format is recommended)-6-

SCIENTIFIC PROGRAM
Sessions
Session 1: Polyamine and Health 1
Session 2: Therapeutic Applications of Polyamines in Cancer and Other Diseases 1
Session 3: Polyamines in Plants and Microorganisms 1
Session 4: Polyamines in Plants and Microorganisms 2
Session 5: Polyamine and Health 2
Session 6: Polyamines in Plants and Microorganisms 3
Session 7: Therapeutic Applications of Polyamines in Cancer and Other Diseases 2
Session 8: Gene Regulation by Polyamines
Session 9: Polyamines in Plants and Microorganisms 4
Session 10: Therapeutic Applications of Polyamines in Cancer and Other Diseases 3
Session 11: Polyamine and Medicinal Chemistry-7-

Sunday, August 25th
13:00 – 19:00

Registration at the Shinsho Hall, connected to the Ariston Hotel

16:30 – 16:45

Opening Ceremony
Opening remarks
Shinsuke Fujiwara, Kwansei-Gakuin University
Congratulatory address
Keiji Maruoka, Director, Yamada Science Foundation
Graduate School of Phamaceutical Science,
Kyoto University
Welcome message
Yasutoshi Mori, President, Kwansei Gakuin University

16:50 – 18:20

Keynote lecture
Session leaders: S. Gilmour (Lankenau Instit Medica Research,USA)T. Oka (Wakunaga Pharmaceutical Co. Ltd, Japan)

16:50 – 17:35[PL 01]

Unusual Features of Antizyme and a Discussion on Its Role
S. Matsufuji (The Jikei University School of Medicine, Japan)

17:35 – 18:20 [PL 02]

Polyamine
enzymaticoxidation
products
inducemitochondrial dysfunction mediated cytotoxicity in humancancer cells detected by electronic microscopy, flow
cytometry and proteomic analyses
E. Agostinelli (Sapienza University of Rome, Italy)

18:30 – 20:00

Welcome party
Barcelona Hall (16F) of the Ariston Hotel-8-

Monday, August 26th
8:30 – 19:00

Registration at the Shinsho Hall, connected to the Ariston Hotel

8:40 – 10:20

Session 1: Polyamine and Health 1
Session leaders: S. Roberts (Pacific University Oregon USA)
M. Ohkido (The Jikei University School of Medicine,Japan)

8:40 – 9:05 [L 03] Spermidine recovers age-related immune suppression by direct
activation of fatty acid oxidation
K. Chamoto (Kyoto University, Japan)
9:05 – 9:30 [L 04] Autophagy as a pathway to rejuvenate immune responses
G. Alsaleh (Botnar Institute for Musculoskeletal Sciences, Oxford
University, UK)
9:30 – 9:55 [L 05] Polyamine Production by Fermentation and Gut Bacteria
S. Kurihara (Kindai University, Japan)
9:55–10:20 [L 06] Spermidine protects brain aging from the effects of high-protein-diet
S. Sigrist (Free University of Berlin, Germany)
Coffee break (Group photo at Conference Center Lobby)
10:50 – 12:30

Session 2: Therapeutic Applications of Polyamines in Cancer andOther Diseases 1
Session leaders: O. Phanstiel (University of Central Florida, Orlando,
USA)
N. Murai (The Jikei University School Medicine, Japan)

10:50 – 11:15 [L 07] Polyamines and Electrophiles in Gastrointestinal Cancer
K. Wilson (Vanderbilt University Medical Center, USA)-9-

11:15–11:35 [L 08] Polyamine deprivation enhances survival and chemotherapy resistancein prostate cancer cells
A. Zabala (Center for Cooperative Research in Biosciences, Spain)
11:35–11:55 [L 09] The role of the polyamine/hypusine pathway in homeostasis,
inflammation, and carcinogenesis of the colon
A. Gobert (Vanderbilt University School of Medicine, USA)11:55–12:15 [L 10] Dual targeting of polyamine biosynthesis and uptake limits
progression of acute leukaemias
G. Weiman (University of New South Wales, Australia)
12:15 – 12:30 [L 11] The novel inhibitory effect of GC7 (N1-Guanyl-1,7diaminoheptane) on Bovine serum amine oxidase
T. Tahara (Sapienza, University of Rome, Rome, Italy)
12:30 – 13:45

Lunch at Valencia Hall (2F) of Ariston Hotel

13:45 – 15:10

Session 3: Polyamines in Plants and Microorganisms 1
Session leaders: H-J Lin (National Taiwan Ocean University, Taiwan)
T. Ikeda (Hiroshima University, Japan)

13:45–14:10 [L 12] Biosynthetic evolution of the polyamine pan-metabolome
A. J. Michael (University of Texas Southwestern, USA)
14:10–14:35 [L 13] Unique polyamines produced by an extremely thermophilic bacterium,
Thermus thermophilus
T. Oshima (Kyowa-Kako.Co, Japan)
14:35–14:50[L14]

Enzymatic Characteristics of Aminopropyltransferases inHyperthermophilic Microorganisms: Comparative Analysis of
Branched Chain Polyamine and Norspermine Synthesis
W. Fukuda (National Institute of Technology and Evaluation, Japan)- 10 -

14:50–15:10 [L15] Biological Role of Branched-chain Polyamines in Survival ofHyperthermophiles under Extremal Conditions
S. Fujiwara (Kwansei Gakuin University, Japan)
15:10 – 16:45

Session 4: Polyamines in Plants and Microorganisms 2
Session leaders: F. Vianello (University of Padua, Italy)
Y. Ishii (Kwansei-GakuinUniversity, Japan)

15:10 –15:35 [L 16] Long-chain polyamines embedded in biogenic silica formed on thesurface of bacterial spores and their biosynthetic pathway
T. Ikeda (Hiroshima University, Japan)
15:35 –16:00 [L17] Deciphering the Molecular Mechanism behind Diatom-Derived
Polyamines in Multifaceted Physiological Functions
H-J Lin (National Taiwan Ocean University, Taiwan)
16:00 – 16:20 [L 18] TILLING population barley mutants in studies of modification ofpolyamine metabolism in the context of their stay-green potential
E. Sobieszczuk-Nowicka (Adam Mickiewicz University in Poznań,Poland)16:20–16:45 [L 19] The hypusine pathway in the European tick Ixodes rizinus:
Molecular Cloning and characterization of deoxyhypusine synthase asa novel target for drug discovery to treat and prevent vector borne
diseases
A. Kaiser (Universität Duisburg-Essen, Germany)
16:45 - 19:00

Poster exhibition (Odd numbers)

19:00 – Dinner at Barcelona Hall (16F) of the Ariston Hotel---------21:00

Happy hour with drinks at poster presentation room

- 11 -

Tuesday, August 27th
8:30 – 17:00

Registration at the Shinsho Hall, connected to the Ariston Hotel

8:40 – 11:30

Session 5: Polyamine and Health 2
Session leaders: L. Vardy (A*STAR Skin Research Labs, Singapore)
S. Sigrist (Free University of Berlin, Germany)

8:40 – 9:05 [L 20] Potential of gut microbiome-derived polyamine as a source ofpolyamines
M. Matsumoto (Kyodo Milk, Japan)
9:05 – 9:30 [L 21] A conserved role for polyamines during fasting
S. Hofer (Max-Delbrück-Center for Molecular Medicine, University ofGraz, Austria)
9:30 – 9:55 [L 22] Polyamine-dependent metabolic shielding regulates alternative splicing
A. Carracedo (Center for Cooperative Research in Biosciences, Spain)
9:55 – 10:20 [L 23] Aging associated changes in polyamine metabolism is a potential target
for novel anti-aging technology
T. Uemura (Josai University, Japan)
Coffee break
10:50 – 11:10 [L 24] NF-E2-related factor 1 suppresses the expression of a spermineoxidase and the production of highly reactive acrolein
T. Hirakawa (Saga University, Japan)
11:10–11:30 [L 25] Metabolic crosstalk of nitric oxide and polyamines in regulating
inflammatory responses by activated macrophages in mouse
T. Osaki (Yamagata University, Japan)- 12 -

11:30 – 12:55

Session 6: Polyamines in Plants and Microorganisms 3
Session leaders: A. J. Michael (University of Texas Southwestern, USA)
A. Szepesi (University of Szeged, Hungary)

11:30–11:55 [L 26] Elucidating the Vital Role of Putrescine: Insights into Leishmania
Biology and Therapeutic Potential
S. Roberts (Pacific University Oregon, USA)11:55–12:20 [L 27] Getting High on Putrescine: Metabolic Engineering of the Polyamine
Pathway in plants
S. Minocha (University of New Hampshire, USA)
12:20–12:55 [L 28] Exploring the action of thermospermine on the mRNA translation ofbHLH proteins in Arabidopsis thaliana
T. Takahashi (Okayama University, Japan)
12:55 – 14:30

Lunch at Valencia Hall (2F) of Ariston Hotel

12:55 - 14:30

Lunch-meeting International Polyamines Foundation - ONLUS
All the members, Board of Governor and Scientific Committee areinvited to be present

14:30 – 16:45

Session 7: Therapeutic Applications of Polyamines in Cancer andOther Diseases 2
Session leaders: E. Agostinelli (Sapienza University of Rome, Italy)
T. Uemura (Josai University, Japan)

14:30–14:55 [L 29] Use of polyamine blocking therapy to treat therapy-resistant cancer
S. Gilmour (Lankenau Institute for Medical Research, USA)
14:55–15:15 [L 30] Unveiling the molecular and biological effects of GC7 in prostatecancerM. Pujana Vaquerizo (Center for Cooperative Research in Biosciences,
Spain)- 13 -

15:15–15:40 [L 31] Targeting Aberrant Polyamine Homeostasis to Treat Snyder-Robinson
Syndrome
T. Murray Stewart (Johns Hopkins School of Medicine, USA)
15:40 –16:00 [L 32] Polyamine pathway inhibitor DENSPM suppresses lipid metabolism
in pheochromocytoma cell line
S. Tevosian (University of Florida, USA)
16:00–16:20[L 33] Bachmann-Bupp Syndrome: Clinical and Metabolomic Manifestationsof DFMO Treatment
E. VanSickle (Helen DeVos Children's Hospital, USA)
16:20–16:45[L 34] Novel Disease Mechanisms Linked to Impaired Polyamine Transport
P. Vangheluwe (Laboratory of Cellular Transport Systems, KU Leuven,
Belgium)
16:45 - 19:00

Poster exhibition (Even numbers)

19:00 – Dinner at Barcelona Hall (16F) of the Ariston Hotel---------21:00

Happy hour with drinks at poster presentation room
(Vote for Poster Awards)- 14 -

Wednesday, August 28th
9:00 – 20:30

Excursion- 15 -

Thursday, August 29th
9:00 – 11:45

Session 8: Gene Regulation by Polyamines
Session leaders: K.T. Wilson (Vanderbilt University Medical Center, USA)K. Nishimura (International University of Health andWelfare, Japan)

9:00–9:20 [L 35] Halfway to Hypusine: Structural Insights into eIF5A
Deoxyhypusination
P. Grudnik (Jagiellonian University, Poland)
9:20–9:40 [L 36] Chemical genomics reveals a novel link between eIF5A hypusinationand mitochondrial integrity
K. Matsumoto (Chemical Genomics Research Group, RIKEN CSRS,Japan)
9:40–10:00 [L 37] Roles of the polyamine-hypusine circuit in the development andmalignant transformation of B-cells
S. Nakanishi (Moffitt Cancer Center and the Research Institute, USA)
10:00–10:25 [L 38] Polyamine-modulated expression of eIF5A2 plays a critical role inproliferation of human cancer cell lines
K. Higashi (Tokyo University of Science, Japan)
Coffee break
10:55–11:20 [L 39] Polyamines Stabilizing Effect on Hybrid RNA:DNA Triplexes
F. Vianello (University of Padua, Italy)
11:20–11:45 [L 40] Lipid-dependence of polyamine transport
K. P. K. Lee (The Pennsylvania State University, USA)- 16 -

11:45 – 12:30

Session 9: Polyamines in Plants and Microorganisms 4
Session leaders: S. Minocha (University of New Hampshire, USA)
T. Takahashi (Okayama University, Japan)

11:45–12:10 [L 41] Exploring the relationship between polyamine catabolism andhypusination in plants
A. Szepesi (University of Szeged, Hungary)
12:10–12:30 [L 42] The signaling triad ‘nitric oxide-polyamine cycle-hydrogen peroxide’
regulates barley leaf senescence
M. Arasimowicz-Jelonek (Adam Mickiewicz University in Poznań,Poland)12:30 – 13:45

Lunch at Valencia Hall (2F) of Ariston Hotel

13:45 – 14:50

Session 10: Therapeutic Applications of Polyamines in Cancer andOther Diseases 3
Session leaders: T. Murray Stewart (Johns Hopkins School of
Medicine, USA)
K. Higashi ( Tokyo University of Science, Japan)

13:45 – 14:10 [L 43] Polyamines: Novel regulators of human epidermal pigmentation
L. Vardy (A*STAR Skin Research Labs, Singapore)
14:10 – 14:30 [L 44] SARS-CoV-2 helicase (NSP13) interacts with mammalian polyamineand HSPs partners in promoting viral replication
H. Makhoba (University of South Africa)
14:30–14:50 [L 45] ATP citrate lyase suppresses the cell death of ornithine decarboxylaseoverproducing cells
A. Tajima (The Jikei University School of Medicine, Japan)
Coffee break- 17 -

15:20 – 16:25

Session 11: Polyamine and Medicinal Chemistry
Session leaders: S. Hofer (Max Delbrueck Center for Molecular
Medicine, Germany & University of Graz, Austria)
M. Minamisawa (Chiba Institute of Technology, Japan)

15:20–15:45 [L 46] Development of LAT1 Efflux Agonists as a Polyamine Depletion
Strategy
O. Phanstiel (University of Central Florida, USA)
15:45–16:05 [L 47] Interrogate the polyamine metabolic network with protein design andinhibitors
S. Liu (Hubei University of Technology, China)
16:05–16:25 [L 48]Biologically active analogues of methionine and S-adenosylmethionine
Alex Khomutov (Engelhardt Institute of Molecular Biology, Russia)
16:25–16:45

Concluding Remarks
K. Igarashi (Amine Pharma Research Institute, Japan)

Poster removal
17:15

Transfer to the Sorakuen by chartered bus

18:30 – 20:30

Gala Dinner: Awards for poster presentation/exhibition will be
conferred.

21:00

Back to Ariston Hotel by chartered bus- 18 -

Friday, August 30th
Departure to Kansai International Airport (KIX) and Osaka International Airport (ITAMI)- 19 -

Poster Session[P01] Expression and function of vesicular polyamine transporter in lung alveolar
epithelial cells
M. Hiasa (Department of Pharmaceutical Sciences, Okayama University, Japan)[P02] Involvement of polyamine on surfactant release from Type II alveolar epithelial
cells
K. Hayakata (Department of Pharmaceutical Sciences, Okayama University, Japan)[P03] Polyamine release and vesicular polyamine transporter expression inmegakaryoblastic cells and platelets
H. Omote (Department of Pharmaceutical Sciences, Okayama University, Japan)[P04] Polyamine secretion and vesicular polyamine transporter in cerebellar Purkinje
neurons
M. Kamitani (Department of Pharmaceutical Sciences, Okayama University, Japan)[P05] Effect of polyamine depletion on the function of glycocalyx in human endothelial
cells
R. Suzuki (Sch. Pharm., Tokyo Univ. Pharm. Life Sci., Japan)[P06] ATP13A3 variants promote pulmonary arterial hypertension by disrupting
polyamine transport
M. Azfar (Department of Cellular and Molecular Medicine, KU Leuven, Belgium)[P07] Effect of acrolein exposure of scission activity of mouse heparanase
M. Moroshita (Grad. Sch. Pharm. Sci., Tokyo Univ. Sci., Japan)[P08] ERK1/2 dependent regulation of eIF5A deoxyhypusination: structuralcharacterization of the DHS-ERK2 complex
P. Kochanowski (Malopolska Centre of Biotechnology, Jagiellonian University,
Poland)[P09] Potential of gut microbiome-derived polyamine as a source of polyamines
N. Ono (Kyodo Milk Industry Co., Ltd., Japan)- 20 -

[P10] Administration of L-arginine and limonoids activates the poly-amine pathway andrestores mitochondrial function in the liver and brain of human Alzheimer’s disease
mouse model
M. Minamisawa ( Chiba Institute of Technology, Japan)[P11] Spermidine promotes regeneration after skeletal muscle chemical injury
T. Iwata (University of Tsukuba, Japan)[P12] Investigating gut immunity-mediated suppression of pathology in a mouse modelof Alzheimer’s disease
S. Sudo (Chiba Institute of Technology, Japan)[P13] Biorthogonal probes for studying polyamine-protein interactions, polyaminetransport and processing in live cells.
R. Serwa (IMol, Polish Academy of Sciences, Warsaw, Poland , Poland)[P14] A study on the significance of polyamine analysis as a biomarker in a mouse modelof Alzheimer's disease.
S. Akagi (Chiba Institute of Technology, japan)[P15] Degradation of chondroitin sulfate and hyaluronan by HYAL1 in brain tissue
at the onset of depression
M. Shimekake (Grad. Sch. Pharm. Sci., Tokyo Univ. Sci., Japan)[P16] Effects of orally ingested polyamines on growth stage and physical activity of
Drosophila melanogaster
T. Fujita (Kindai University, Japan)[P17] Bacteria-derived putrescine regulates intestinal permeability by enhancing celljunction protein translation
A. Nakamura (Kyodo Milk Industry Co., Ltd., Japan)[P18] Spermidine administration alleviates the inflammation triggered by cerebral
infarction
M. Matsunaga (Grad. Sch. Fac. Pharm. Sci., Tokyo Univ. Sci., Japan)- 21 -

[P19] Functional characterization of ATP13A2 variants associated with distinct
neurodegenerative disorders
S. Vrijsen (Laboratory of Cellular Transport Systems, KU Leuven, Belgium, Belgium)[P20] Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis
through acrolein production
K. McNamara (Program in Cancer Biology, Vanderbilt University, United States)[P21] Hyp’Assay: Development of a new non-radioactive assay for the discovery of
inhibitors of the polyamine-hypusine axis
O. Benaceur (Inserm U1065, France)[P22] The polyamine transporter ATP13A3 mediates DFMO-induced polyamine uptake
in neuroblastoma
W. Gao (Children’s Cancer Institute, University of New South Wales, Australia)[P23] A role for polyamine catabolism in epidermal wound healing
M. Shi (A*STAR Skin Research Labs, Singapore)[P24] Dietary polyamines facilitate intestinal adaptation in an experimental model ofshort bowel syndrome
N. Kasahara (Department of Surgery, Jichi Medical University, Japan)[P25] Effect of co-administration of N-acetylcysteine and low-molecular-weight heparinon the inflammation of stroke onset
A. Sekiguchi (Graduate school of Pharmaceutica Science, Tokyo Univ. of Science, Japan)[P26] Combined drug approach to enhance the anticancer effects of statins
K. Mizoguchi (Kwansei Gakuin University, Japan)[P27] Polyamine improves the surface activity of the diluted lung surfactant and inflates
the collapsed lungs of a rat model of acute respiratory distress syndrome.
M. Ohkido (Dept of Mol Biol, The Jikei University School of Medicine, Japan)- 22 -

[P28] Photoreceptor dysfunction induced by a polyamine analogue attenuates retinal
neovascularization in oxygen-induced retinopathy mouse model
J-H. Kim (Seoul National University Hospital, Republic of Korea)[P29] C-Methylated analogues of spermine: synthesis and biological application
M. Khomutov (Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia, RussianFederation)[P30] Crystallographic fragment screening in search for specific inhibitorsof hypusination.
P. Wilk (MAX IV laboratory, Lund University, Poland)[P31] Antizyme 2 accelerates ubiquitin independent MYCN degradation and contributes
to suppression of neuroblastoma tumorigenesis
N. Murai (The Jikei University School of Medicine , Japan)[P32] Role of branched-chain polyamines in survival of hyperthermophiles understressed conditions
R. Satake (Department of Biosciences, Kwansei Gakuin University, Japan)[P33] Effect of polyamines on RAN translation from CCUG repeats
A. Oguro (The Jikei University School of Medicine, Japan)[P34] Human eIF5A2 regulated by polyamines at translational level participates inmRNA decoding distinct from eIF5A1.
M. Suzuki (Fac. Pharm. Sci., Tokyo Univ. Sci., Japan)[P35] Polyamine-mediated regulation of de novo biosynthesis of purine
K. Nishimura (School of Pharmacy, International University of Health and Welfare,Japan)[P36] Effect of polyamine depletion on the hyaluronan synthesis in human pancreatic
ductal adenocarcinoma
K. Tsuji (Graduate school of Pharmaceutica Science, Tokyo Univ. of Science, Japan)- 23 -

[P37] Exploration of an novel fused polyamine synthase in marine diatoms
Phaeodactylum tricornutum influencing silica content variation in frustule.
M-H. Hsu (Institute of Biotechnology, National Taiwan Ocean University , Taiwan)[P38] Revealing the Growth-Promoting Role of Spermidine Synthase-Based Polyamine
Biosynthetic Pathway in Marine Diatom Phaeodactylum tricornutum
C-Y. Hsuan (Institute of Biotechnology, National Taiwan Ocean University, Taiwan)[P39] Characterization of Polyamine Accumulation in Mold-Fermented Cheese Using
Mass Spectrometry Imaging
N. Ogawa (Department of Biosciences, Kwansei Gakuin University, Japan)[P40] Polyamines modulate the capsule biosynthesis in Neisseria meningitidis by altering
the central metabolic pathway
T. Haldar (Symbiosis School of Biological Sciences, India)[P41] Extracellular spermidine modulates virulence of S. pyogenes
A. Bhagwat (Symbiosis School of Biological Sciences, India)[P42] Thermpspermine synthase-mediated polyamine biosynthesis pathway in marine
diatoms featuring diverse uncommon polyamines and high-salt adaptation
S-W. Lin (Institute of Biotechnology, National Taiwan Ocean University, Taiwan)[P43] Exploring Novel Thermospermine Oxidase in Thermophilic Archaeon
Pyrobaculum calidifontis
K. Maekawa (Department of Biosciences, Kwansei Gakuin University, Japan)[P44] DNA recognition mechanism of transcriptional regulator PuuR in Putrescine
utilization pathway
N. Nemoto (Faculty of Advanced Engineering, Chiba Institute of Technology, Japan)[P45] Suppression of the dwarf phenotype of an Arabidopsis mutant defective inthermospermine biosynthesis by a mutant of tRNA sulfur modification
Y. Nishii (Graduate School of Natural Science, Okayama University, Japan)- 24 -

[P46] Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis
questions the deoxyhypusine synthase bifunctionality
E. Wator (Malopolska Centre of Biotechnology, Jagiellonian University, Poland)[P47] Conversion of Soy-Bean Derived Indigestible Peptides to Putrescine by Gut
Microbes
Y. Ami (Kindai University, Japan)[P48] Phylogenetic and Functional Analyses of Arginine Decarboxylase in Aspergillus
oryzae: Insights into Agmatine Production during Sake Fermentation
Y. Murakami (Grad. Sch. Sci. Technol., Kwansei Gakuin Univ. , Japan)[P49] Knowledge Inventory for Polyamine Biosynthesis Pathway of Thermus
thermophilus in ThermusQ
T. Moriya (Inst. Environ. Microbiol., Kyowa Kako Co., Ltd., , Japan)[P50] Elucidating the Role of Polyamines in Cellular Proliferation and Metabolic Activity
in the Protozoan Parasite Leishmania donovani
J. Johnston (School of Pharmacy, Pacific University, United States)[P51] Mechanism of pH-responsive Structural Maintenance of the Transcriptional
Regulator Lrp Governing Polyamine Homeostasis
Y. Ishii (Kwansei Gakuin University, Japan)[P52] Producing New Methyl Polyamines by N-Methyltransferase-Coupled Predicted
Data Mining Approach
T-S. Chang (National University of Tainan, Taiwan)[P53] Metabolic engineering Escherichia coli with marine diatom thermospermine
synthase-based pathway for longer uncommon polyamine homocaldopentamine
production: An anti-stress molecule
H-Y. Lin (Institute of Biotechnology, National Taiwan Ocean University, Taiwan)- 25 -

[P54] Unveiling the Reaction Mechanism of Arginine Decarboxylase in Aspergillus
oryzae: Insights from Crystal Structure Analysis
Y. Odagaki (Graduate School of Agriculture, Kyoto University, Japan)[P55] Studies on the synthesis of novel polyamine-based biopolymers using branchedchain polyamine synthase and long-chain polyamine synthase
N. Murakami (Graduate School of Integrated Science for Life, Hiroshima Univ., Japan)[P56] ROS-mediated reduction of Caco-2 cell viability upon internalization of a spermineoxidase nano-catalyst
G. Rilievo (Dpt. of Comparative Biomedicine and Food Science, Univ. of Padua, Italy)[P57] Role of polyamines in virulence and pathogenesis of Streptococcus pyogenes
H. Rathod (Symbiosis School of Biological Sciences, Deemed University, India)[P58] The polyamine-hypusine axis regulates tissue resident memory T cell fate andfunctionsA. G. Elmarsafawi (H. Lee Moffitt Cancer Center & Research Institute , USA)- 26 -

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