INSECTICIDECHLORFLUAZURON
Insect growth regulator
Chlorfluazuron is one of the leading benzoylphenylurea IGR insecticides.
This compound, discovered and developed by ISK, was launched in the late1980’s. Since then, chlorfluazuron has been globally used under the trademarkof Atabron for controlling Lepidopteran pests on cotton, bean, vegetables andfruit trees, etc.
Chlorfluazuron is an insect growth regulator that inhibits chitin synthesis andprovides good control of various pest insects, especially Lepidoptera, at a low
dose rate.
Chlorfluazuron has very little negative impact on natural enemies and pollinatinginsects, and can be used in integrated pest management programs.

Physico-Chemical Properties

Toxicology & Ecotoxicology

Chemical structure
CI
F3C

Rat LD50 (oral) : > 8,500 mg/kg (m/f)
Rat LD50 (dermal) : > 1,000 mg/kg (m/f)
Rat LC50 (inhalation) : > 2.4 mg/L (4 h) (x/f)

FCI

NHCONHCOON

Skin irritation : non irritant (rabbit)
Eye irritation : irritant but also physical irritant (rabbit)
Skin sensitization : not a sensitizer (guinea pig)

FCIClass : benzoylurea
IUPAC name : 1-[3,5-dichloro-4-(3-chloro-5trifluoromethyl-2-pyridyloxy) phenyl]3-(2,6-difluorobenzoyl)urea
Molecular weight : 540.7
Molecular formula : C20H9Cl3F5N3O3
Vapour pressure : 1.599x10-3 mPa (20°C)
Water solubility : 0.012 mg/L (20°C)
Form : White solid
Development code : IKI-7899

Avian LD50 (acute oral) : > 2,510 mg/kg (quail)Avian LD50 (acute oral) : > 2,510 mg/kg (mallard ducks)
Fish LC50 : > 1,071 mg/L (bluegill, 96 h)
Bees LD50 (oral) : >100 μg/beeDaphnia magna EC50 : 0.304 μg/L (48 h)

Application

Mode of Action

Control of Lepidoptera such as Helicoverpa, Spodoptera and Pseudoplusia on soybean; and Plutella, Spodoptera and thrips on vegetables;
Adoxophyes, Ascotis on tea and fruit trees. Also used on potatoes,ornamentals and turf. Application rate : 10-100 g a.i./ha

Chlorfluazuron, which acts as an anti-molting agent, inhibits biosynthesisof chitin in the insect cuticle, which causes loss of cuticle elasticity andfirmness, and results in abortive molting.
It belongs to IRAC Group 15.

Product
Trade Names

ATABRON, ISHIPRON, NICE EAGLE, 愛扶農, 抑太保, etc.

Formulations

5%EC, 10%SC

Registered Countries

Asia

China, India, Japan, Philippines, South Korea, Taiwan, Thailand, Vietnam, etc.

Americas

Argentine, Brazil, Peru, etc.

Crops

Corn, Cotton, Fruit trees, Soybean, Tea, Turf, Vegetables, etc.

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154

CHLORFLUAZURONINSECTICIDE

Insect growth regulator

Inhibition of Larval Molting of Spodoptera
litura by Chlorfluazuron Application

Characterisitics
Chitin synthesis inhibitor
Interrupts insect molting and growth
Active against larval stages of a broad spectrumof Lepidopteran insects
Long residual activity
Active against certain Coleoptera, Hemiptera,
Thysanoptera and Blattodea
Stomach toxin - active through ingestion

NormalEffective at low rates (10-100 g a.i./ha)Easy to use (liquid formulation)

Abnormal molting when chlorfluazuon was treated at
5th instar larvae

Safe to beneficial insectsThe Efficacy of Chlorfluazuron on DBM (7 days after application)

Untreated cabbage

Chlorfluazuron 5%EC/1 L/ha (50 g a.i./ha)Pest Spectrum
Lepidoptera

Acrolepiopsis nagaimo

Adoxophyes honmai

Adoxophyes orana

Agrotis ipsilon

Alabama argilacea

Anticarsia gemmatalis

Archips audax

Archips breviplicanus

Archips fuscocupreanus

Ascia monuste

Ascotis selenaria

Autographa nigrisigna

Diaphania indica

Helicoverpa armigera

Hellula undalis

Homona magnanima

Mamestra brassicae

Orgyia thyellina

Parapediasia teterrella

Pieris rapae

Plutella xylostella

Pseudoplusia includens

Rachiplusia nu

Rhopobota naevana

Spodoptera depravata

Spodoptera exigua

Spodoptera frugiperda

Spodoptera litura

Stathmopoda masinissa

Tuta absoluta

Hemiptera

Whitefly

Bemisia tabacii

Trialeurodes vaporariorum

Thysanoptera

ThripsThrips palmi

Thrips tabaciFrankliniella occidentalis

Ponticulothrips diospyrosi
Blattodea

TermiteColeoptera

Helicoverpa armigera

Coptotermes formosanus

Reticulitermes speratus

Anomala octiescostata.

Cassida nebulosa

Popillia japonica

Sphenophorus venatus

Spodoptera litura

ISHIHARA SANGYO KAISHA, LTD.

Phyllotreta striolataPlutella xyloatella

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154