INSECTICIDE

Cyclaniliprole (CYCLAPRYN )TM

Wide spectrum insecticide
Cyclaniliprole is a diamide insecticide (IRAC Group 28) discovered by ISK.
Cyclaniliprole is highly effective against numerous insect pest in various
orders, including Lepidoptera, Coleoptera, Hemiptera, Thysanoptera andDiptera. With its combination of good rainfastness and long-lasting efficacy
the use of Cyclaniliprole will aid in reducing the number of necessary
insecticide application. In addition to its outstanding efficacy, Cyclaniliprole
has excellent crop safety for all registered crops.
ISK has developed Cyclaniliprole since 2004 and obtained initial registrations in Korea, US, Canada and Japan in 2017. Cyclaniliprole is now
registered in 13 countries. ISK is currently expanding the approved uses of
Cyclaniliprole and is pursuing additional registrations in other countries.

Physico-Chemical Properties
Chemical structure

Toxicology & Ecotoxicology
HNBr

Rat LD50 (oral) : > 2,000 mg/kg (f)Rat LD50 (dermal) : > 2,000 mg/kg (m/f)
Rat LC50 (inhalation) : > 4.62 mg/L (m/f)

OCH3HNClBrNNOClN

Class : Diamide
IUPAC name : 2',3-dibromo-4'-chloro-1-(3-chloro-2pyridyl)-6'-{[(1RS)-1-cyclopropylethyl]
carbamoyl}pyrazole-5-carboxanilide
Molecular weight : 602.1
Molecular formula : C21H17Br2Cl2N5O2
Vapour pressure : 2.4 x 10-6 Pa (25°C)
Water solubility : 0.15 mg/L (20°C)
Form : White crystalline solid
Development code : IKI-3106

Skin irritation : non irritant (rabbit)
Eye irritation : GHS Not classified (rabbit)
Skin sensitization : not a sensitizer (guinea pig)
Avian LD50 (acute oral) : > 2,000 mg/kg (quail, m/f)
Avian LD50 (subacute oral) : > 5,000 ppm in feed (quail)
Fish LC50 : > 0.630 mg/L (carp, 96 h)
Bees LD50 (acute oral) : 0.66μg a.i./bee (96 h)
Bees LD50 (acute contact) : 0.83μg a.i./bee (96 h)Daphnia magna EC50 : 0.0808 mg/L (48 h)Mode of Action
Cyclaniliprole acts by selective activation of the ryanodine receptor (RyR) in the sarcoplasmic reticulum of target insect
pests. Once exposed, through contact or ingestion, Cyclaniliprole attaches to the insect RyR inducing the uncontrolled
release of calcium stores present in muscle cells.
Symptomology after treatment involves immediate feeding cessation, muscle contraction, paralysis and eventual
death. In addition, Cyclaniliprole has been shown to be minimally active on the RyR of mammals due to its highselectivity and favorable toxicological profile.

Treated by Cyclaniliprole

Untreated

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154

Cyclaniliprole (CYCLAPRYN )INSECTICIDETM

Wide spectrum insecticide

Characteristics
・IRAC Group 28

・Mode of action: Ryanodine receptor modulator (RyRMs)

・Broad spectrum activity protecting plants from numerous pest species
・Highly effective in controlling most major species of lepidopteran pests
・Efficacious by contact and ingestion

・Requires less active ingredient compared to most other diamide insecticides
・Provides rapid feeding cessation and long-lasting control

・Excellent efficacy on various pest life stages resulting in reduced damage

Spodoptera frugiperda

・Adulticidal activity leading to fewer eggs present in treated crops

Pest Spectrum

Lepidoptera

Coleoptera

Hemiptera

Thysanoptera

DipteraAmyelois transitella

Anarsia lineatella

Carposina sasakii

Chilo suppressalis

Choristoneura rosaceana

Cydia caryana

Cydia molesta

Cydia pomonella

Diaphania hyalinata

Diaphania nitidalis

Glossosphecia romanovi

Grapholita dimorpha

Grapholita molesta

Helicoverpa armigera

Helicoverpa zea

Heliothis virescens

Lyonetia clerkella

Neoleucinodes elegantalis

Ostrinia nubilalis

Paralobesia viteana

Pieris rapae

Plutella xylostella

Spodoptera eridania

Spodoptera exigua

Spodoptera frugiperda

Spodoptera litura

Spodoptera sunia

Tecia solanivora

Trichoplusia ni

Tuta absoluta

Acalymma vittatum

Anthonomus eugenii

Aromia bungii

Conotrachelus nenuphar

Hypothenemus hampei

Leptinotarsa decemlineata

Popillia japonica

Premnotrypes suturicallus

Premnotrypes vorax

Aphis gossypii

Bactericera cockerelli

Bemisia tabaciDavidsonaspis aguacatae

Diaphorina citri

Hemiberlesia lataniae

Lygus lineolaris

Myzus persicae

Plautia crossota

Frankliniella occidentalis

Scirtothrips dorsalis

Scirtothrips perseae

Thrips hawaiiensis

Thrips palmi

Thrips tabaci

Bactrocera tsuneonis

Drosophila suzukii

Liriomyza sativae

Liriomyza trifolii

Prodiplosis longifila

Rhagoletis pomonella

Anthonomus eugenii

Bemisia tabaci

Scirtothrips dorsalis

and more

Drosophila suzukii

ProductTrade Names

TEPPAN, MUTEKI, HARVANTA, VERDEPRYN, SARISA, RAPITAN etc

Formulations

5%SL, 10%SL etc.

Registered Countries

Asia

Japan, Korea, Vietnam

Oceania

Australia

AmericasBrazil, Canada, Chile, Colombia, Guatemala, Honduras, Mexico, Peru, USA

Always read and follow the product label instructions in your country.

ISHIHARA SANGYO KAISHA, LTD.

URL : http://www.iskweb.co.jp

E-mail : isk.bio@iskweb.co.jp

1-3-15 Edobori, Nishi-ku, Osaka 550-0002 TEL +81-6-6444-7154