ࢄ  Օ  ग़!
 ࡇࡢᗘࠊᖹᡂᖺ᭶᪥㸦ᅵ㸧࡟ࠊஂ␃⡿ᕷෆࡢஂ␃⡿኱Ꮫ་Ꮫ㒊࢟ࣕࣥࣃࢫ࡟ࡈ
ࡊ࠸ࡲࡍ⟃Ỉ఍㤋࡛➨ᅇẟ㧥⛉Ꮫ◊✲఍ࢆஂ␃⡿኱Ꮫ⓶⭵⛉Ꮫᩍᐊࡀ࠾ୡヰࡉࡏ࡚࠸ࡓࡔࡃࡇ࡜࡟࡞ࡾࡲࡋࡓࠋᮏ఍ࡣࠊᮾி࡛㛤ദࡍࡿࡇ࡜ࡀཎ๎࡜࡞ࡗ࡚࠾ࡾࡲࡍࡀࠊ
௚ࡢሙᡤ࡛⾜࠺ࡇ࡜ࡶྍ⬟࡛࠶ࡿ࡜࠸࠺つ๎ࡀ࠶ࡿࡓࡵࠊᮏᖺࡣࠊୗグࡢᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ࡢేタࡶ⪃࠼ࠊஂ␃⡿ᕷ࡛㛤ദࡉࡏ࡚࠸ࡓࡔࡃࡇ࡜࡟ࡋࡲࡋࡓࠋ㐲᪉ࡼࡾ࠾㉺ࡋ㡬ࡃඛ⏕࡟ࡣ኱ኚᜍ⦰࡛ࡍࡀࠊ᫝㠀ࠊஂ␃⡿ᕷࡢ㹀⣭ࢢ࣓ࣝ࡜㹀⣭࢚ࣥࢱ࣮ࢸ࢖ࣥ
࣓ࣥࢺࢆ࠾ᴦࡋࡳୗࡉ࠸ࠋ
⚾ࡣẟ㧥⛉Ꮫ࡟㛵ࡋࡲࡋ࡚ࡣᑓ㛛እ࡛ࡋࡓࠋࡋ࠿ࡋࠊ⣙ᖺ๓ࠊஂ␃⡿኱Ꮫ࡟㉱௵ࡋࡓ᫬ࠊᙜ᫬ࡢຓᩍᤵࡢ᳃⌮ඛ⏕ࡀẟ㧥⛉Ꮫࢆ୺࡟◊✲ࡋ࡚࠸ࡓࡓࡵࠊ๓ᩍᤵࡢ➲஭㝧୍㑻ඛ⏕ࡢᚋ㔩࡜ࡋ࡚ࠊᮏ఍ࡸ࠸ࢁ࠸ࢁ࡞ẟ㧥㛵ಀࡢ◊✲఍࡟ධࢀ࡚㡬ࡁࡲࡋࡓࠋ
⌧ᅾࠊஂ␃⡿኱Ꮫ࡛ࡣࠊẟ㧥⑌ᝈࡢ⮫ᗋ࡟㛵ࡋ࡚ࡣࠊ㎞ᓥṇᚿඛ⏕ࡢᑓ㛛እ᮶࡛ࠊ෇
ᙧ⬺ẟ⑕ࢆ୰ᚰ࡟ከࡃࡢẟ㧥⑌ᝈᝈ⪅ࡉࢇࢆデᐹࡋ࡚࠸ࡲࡍࠋ ᭱㏆ࡢୡ⏺ࡢẟ㧥⛉Ꮫ◊✲ࡢⓎᒎ࡟ࡣ┠ࢆぢᙇࡿᛮ࠸࡛ࡍࠋ≉࡟ᖿ⣽⬊ࡸ෌⏕་⒪࡟㛵㐃ࡋࡓከࡃࡢ◊✲ࡀࠊCellࠊNatureࠊScienceࠊCell Stem Cell⣭ࡢࢪ࣮ࣕࢼࣝ࡟ᥖ㍕ࡉࢀ࡚࠸ࡿࡢࢆࡳ࡚ࠊ᫝㠀࡜ࡶஂ␃⡿኱Ꮫ⓶⭵⛉Ꮫᩍᐊ࡛ࡶẟ㧥⛉Ꮫࡢᇶ♏◊✲ࢆ୺せ࡞◊✲㡯┠ࡢࡦ࡜ࡘ࡟ࡋࡓ࠸࡜ᛮ࠸⥆ࡅ࡚࠸ࡲࡍࠋࡲࡓࠊᩘᖺ๓࡟ஂ␃⡿኱Ꮫ་Ꮫ㒊⓶⭵⛉ࡀ୺ദࡋࡓ᪥ᮏ◊✲⓶⭵⛉Ꮫ఍⥲఍ࡢ࡜ࡁࡢpost-meeting symposium࡛ࡶẟ㧥⛉ᏛࢆྲྀࡾୖࡆࠊDr. George CotsarelisࠊDr. Salah MillerࠊDr. Ralf Paus࡞࡝ࡢࠊࡇࡢศ㔝ࡢᶒጾࡢඛ⏕ࢆከᩘᣍ⪸ࡋࡲࡋࡓࠋ ࡇࡢᗘࡣࠊࡲࡔࡲࡔࠊᐇຊࡣᮍ⇍࡛୙༑ศ࡜㔜ࠎㄆ㆑ࡋ࡚࠾ࡾࡲࡍࡀࠊᮏ఍ࡢୡヰேࡢㅖඛ⏕ࡢࡈ᥎ᣲ࡛ࠊᮏ఍ࡢ࠾ୡヰࢆࡉࡏ࡚࠸ࡓࡔࡃࡇ࡜኱ኚගᰤ࡟Ꮡࡌ࡚࠸ࡲࡍࠋ
≉ูㅮ₇࡜ࡋ࡚ⴭ᫂࡞ᴗ⦼ࢆ࠾ᣢࡕࡢࠊ⡿ᅜ༡࢝ࣜࣇ࢛ࣝࢽ࢔኱ᏛࡢCheng-Ming
Chuongඛ⏕࡜୰ᅜ་Ꮫ⛉Ꮫ㝔 ໭ி༠࿴་Ꮫ㝔ࡢXue Zhangඛ⏕ࡢࡈᛌㅙࢆ㡬ࡁࡲࡋࡓࠋࡲࡓࠊᮅ୍␒࡟㸱ྡࡢᾏእࡢⱝᡭ◊✲⪅ࡢ࣑ࢽࢩ࣏ࣥࢪ࣒࢘ࡶ⾜࠸ࡲࡍࠋᩍᐊဨ
඲ဨ࡛ᑡࡋ࡛ࡶᐇࡾ࠶ࡿ఍࡟ࡍࡿࡼ࠺඲ຊ࡛㡹ᙇࡿᡤᏑ࡛ࡍࠋㅖඛ⏕ࡢࡈཧຍ࡜ ࠿࠸ࡈ༠ຊ࡛ࡍࡤࡽࡋ࠸఍࡟ࡋ࡚㡬ࡅࡲࡍࡼ࠺ษ࡟࠾㢪࠸⮴ࡋࡲࡍࠋ ᑦࠊᮏ◊✲఍ࡢ๓᪥ࡢ᭶᪥㸦㔠㸧࡟ࠊ⚾ඹࡢஂ␃⡿኱Ꮫ⓶⭵⣽⬊⏕≀Ꮫ◊✲ᡤ୺ദpre-meeting࡜ࡋ࡚ࠊThe 2nd International Conference for Skin Diseases in Kurumeࢆ㛤ദࡍࡿணᐃ࡛ࡍࠋヲ⣽ࡀỴࡲࡾࡲࡋࡓࡽࠊ෌ᗘࡈ㐃⤡⮴ࡋࡲࡍࡢ࡛ࠊ࠾᫬㛫ࡢవ⿱ࡢ࠶
ࡿඛ⏕ࡣࡇࡕࡽࡢ఍࡟ࡶࡈฟᖍ㡬ࡅࡿ࡜ᖾ⏒࡛ࡍࠋࡑࢀ࡛ࡣࠊஂ␃⡿࡛ᴦࡋ࠸᫬㛫ࢆ㐣ࡈࡋࡲࡋࡻ࠺ࠋ
ᖹᡂᖺ᭶ྜྷ᪥
The 20th Annual Meeting of the SHSR
➨ᅇẟ㧥⛉Ꮫ◊✲఍఍㛗 ᶫᮏ 㝯㸦ஂ␃⡿኱Ꮫ་Ꮫ㒊⓶⭵⛉Ꮫᩍᐊࠊஂ␃⡿኱Ꮫ⓶⭵⣽⬊⏕≀Ꮫ◊✲ᡤ㸧㸫㸫

ల31ٝ࿉ฯ‫ݪࡄڠش‬ٛ‫ٽ‬ါ!
１．学術集会఍ ᮇ㸸ᖹᡂᖺ᭶᪥㸦ᅵ㸧఍ ሙ㸸ஂ␃⡿኱Ꮫ ⟃Ỉ఍㤋ࠛ ⚟ᒸ┴ஂ␃⡿ᕷ᪫⏫  7(/㸸఍ 㛗㸸ᶫᮏ 㝯    ஦ົᒁ㛗㸸㎞ᓥṇᚿࠊྂᮧ༡ኵ
≉ูㅮ₇㸸Environment and Epigenetic Regulation of Hair Stem Cell Regeneration
Cheng-Ming Chuong ඛ⏕(Professor, Department of Pathology, University of Southern California, USA)≉ูㅮ₇㸸Our Genetic Findings in Hair Growth Disorders
Xue Zhang ඛ⏕(Professor and Chairman, Department of Medical Genetics, McKusick-Zhang Center for
Genetic Medicine and State Key Laboratory of Medical Molecular Biology, Institute of
Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical
College, China)

２．総会᪥ ᫬㸸ᖹᡂᖺ᭶᪥㸦ᅵ㸧 ఍ ሙ㸸ஂ␃⡿኱Ꮫ⟃Ỉ఍㤋 㸰㝵ࠕ࢖࣋ࣥࢺ࣮࣍ࣝࠖ

３．世話人会᪥ ᫬㸸ᖹᡂᖺ᭶᪥㸦ᅵ㸧 ఍ ሙ㸸ஂ␃⡿኱Ꮫ⟃Ỉ఍㤋 㸯㝵ࠕᑠ఍㆟ᐊࠖ

４．意見交換会᪥ ᫬㸸ᖹᡂᖺ᭶᪥㸦ᅵ㸧 ఍ ሙ㸸ஂ␃⡿኱Ꮫ⟃Ỉ఍㤋 㸯㝵ࠕ୰఍㆟ᐊ࣭ᑠ఍㆟ᐊࠖ㸫㸫

ٛા͈͒ͺ·ΓΑ༹༷!
バスでのアクセスのご案内㸯㸬す㕲ஂ␃⡿㥐ࣂࢫࢭࣥࢱ࣮࠿ࡽ
⾜ඛ␒ྕ࠙ᕷᙺᡤ⤒⏤኱Ꮫ⑓㝔⾜ࠚ࡟࡚኱Ꮫ⑓㝔࡛ୗ㌴
㸶࠙ᕷᙺᡤ኱Ꮫ⑓㝔⤒⏤㧗ᑓ᪉㠃⾜ࠚ࡟࡚་Ꮫ㒊๓࡛ୗ㌴㸰㸬JRஂ␃⡿㥐࠿ࡽ⾜ඛ␒ྕ㸶࠙኱Ꮫ⑓㝔⤒⏤㧗ᑓ᪉㠃⾜ࠚ࡟࡚་Ꮫ㒊๓࡛ୗ㌴
㸱㸬ᡤせ᫬㛫
す㕲ஂ␃⡿ࣂࢫࢭࣥࢱ࣮㸦ᕷᙺᡤ⤒⏤㸧 ศJRஂ␃⡿㥐              㸵ศ

タクシーでのアクセスのご案内㸯㸬す㕲ஂ␃⡿㥐࠿ࡽ 㹼ศ
㸰㸬JRஂ␃⡿㥐࠿ࡽ ศ

車でのアクセスのご案内஑ᕞ⮬ື㌴㐨 ஂ␃⡿࢖ࣥࢱ࣮࠿ࡽ ⣙ศ఍ሙ࡟ࡣ᭷ᩱࡢཷデ⪅⏝㥔㌴ሙࡀࡈࡊ࠸ࡲࡍࡀࠊ㥔㌴ࢫ࣮࣌ࢫ࡟ࡣ㝈ࡾࡀ࠶ࡾࡲࡍ
ࡢ࡛ࠊ࡛ࡁࡿࡔࡅබඹ஺㏻ᶵ㛵ࢆࡈ฼⏝࠸ࡓࡔࡅࡲࡍࡼ࠺࡟࠾㢪࠸⮴ࡋࡲࡍࠋ㸫㸫

̤౶̵̤ͣ͂‫!̞ܐ‬Ａ）参加者の方々へ㸯㸬ཧຍཷ௜ࡣ༗๓࠿ࡽ࡛ࡍࠋ
㸰㸬ཷ௜ࡣ఍ሙධࡾཱྀ㸯㝵࡛⾜࠸ࡲࡍࠋ࠾ྡ๓ࢆⓏ㘓ࡋࠊཧຍ㈝㸦఍ဨ෇ࠊ
㠀఍ဨ෇㸧ࢆ࠾ᨭᡶ࠸ࡢୖࠊࢿ࣮࣒ࣉ࣮ࣞࢺ㸦㡿཰᭩ව㸧ࢆ࠾ཷࡅྲྀࡾ
࡟࡞ࡾࠊᡤᒓ࣭Ặྡࢆグධࡋ࡚㤳࠿ࡽ࠾᥃ࡅࡃࡔࡉ࠸ࠋ
㸱㸬ࣉࣟࢢ࣒࣭ࣛᢒ㘓㞟ࡣࡈᣢཧୗࡉ࠸ࠋ఍ሙ࡛㉎ධࡉࢀࡿሙྜ࡟ࡣ㸯㒊෇
ࢆࡈ㈇ᢸ࠸ࡓࡔࡁࡲࡍࠋ㸲㸬ពぢ஺᥮఍ࢆ᫬ศࡼࡾ㛤ദ࠸ࡓࡋࡲࡍࠋཧຍⓏ㘓ࢆ࠸ࡓࡔ࠸ࡓ᪉ࡣ↓ᩱ࡛ࡍࡢ࡛ዧࡗ࡚ࡈཧຍࡃࡔࡉ࠸ࠋ
Ｂ）口演者の皆様へ㸯㸬ࢫࣛ࢖ࢻࡣཎ๎ⓗ࡟ⱥㄒ࡛࠾㢪࠸ࡋࡲࡍࠋཱྀ㏙ࡣ᪥ᮏㄒ࡛ࡶⱥㄒ࡛ࡶᵓ࠸ࡲ
ࡏࢇࠋ㸰㸬ཱྀ₇᫬㛫ࡣ㸶ศࠊ㉁␲ᛂ⟅㸲ศ࡛ࡍࠋ
㸱㸬Windows 7࡟ࡼࡿPCࣉࣞࢮࣥࢸ࣮ࢩࣙࣥࡢࡳ࡜ࡋࡲࡍࠋ
㸲㸬఍ሙ࡟⏝ពࡋ࡚࠸ࡿࣃࢯࢥࣥࡣMicrosoft Power Point 2010ࠊ2007ࠊ2003࡟ᑐᛂ࠸ࡓࡋࡲࡍࠋື⏬ࡢ౑⏝ࡣ࡛ࡁࡲࡏࢇࠋ
㸳㸬୙ࡢ஦ែ࡟ഛ࠼࡚ࠊࣂࢵࢡ࢔ࢵࣉࢹ࣮ࢱࢆ࠾ᣢࡕࡃࡔࡉ࠸ࠋ

㸴㸬ࢹ࣮ࢱసᡂᚋࠊ௚ࡢࣃࢯࢥ࡛ࣥṇᖖ࡟సືࡍࡿ࠿☜ㄆࡋ࡚ࡃࡔࡉ࠸ࠋ
㸵㸬Ⓨ⾲ணᐃ᫬้ࡢศ๓ࡲ࡛࡟USB࣓࣮ࣔࣜࡲࡓࡣCD-RࢆPCཷ௜࡟࠾ᣢࡕୗࡉ
࠸ࠋ
㸶㸬Ⓨ⾲ࡢ㝿ࡣࠊ₇ྎ࡟ࢭࢵࢺࡋ࡚࠾ࡾࡲࡍ᧯స⏝࣮࢟ࣃࢵࢻࢆ౑⏝ࡋࠊࡈ⮬㌟
࡟ࡼࡿ᧯సࢆ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
Ｃ）座長の皆様へ㸯㸬ཱྀ₇᫬㛫ࡣ㸯㢟࠶ࡓࡾウㄽ᫬㛫ࢆྵࡵ࡚ศ࡛ࡍࠋ
㸰㸬ḟᗙ㛗ࡢ᪉ࡣࠊணᐃ᫬้ศ๓ࡲ࡛࡟ࠊḟᗙ㛗ᖍ࡟࠾╔ࡁୗࡉ࠸ࠋ

㸫㸫

Ｄ）討論者の皆様へⓎゝࡣᗙ㛗ࡢᣦ♧࡟ᚑ࠸ࠊᚲࡎ࣐࢖ࢡࢆ౑ࡗ࡚ࠊᡤᒓ࣭Ặྡࢆ㏙࡭࡚࠿ࡽࡈウㄽ
ࡃࡔࡉ࠸ࠋ
Ｅ）その他
㸯㸬ཎ๎࡜ࡋ࡚఍ሙෆࡢ࿧ࡧฟࡋࡣ⾜ࡗ࡚࠾ࡾࡲࡏࢇࠋ
㸰㸬఍ሙෆ࣭Ꮫෆ࣭㝔ෆඹ࡟⚗↮࡛ࡍࠋ㸱㸬఍ሙෆ࡛ࡢᦠᖏ㟁ヰࡢࡈ౑⏝ࡣࡈ㐲៖ࡃࡔࡉ࠸ࠋ఍ሙෆ࡛ࡣ㟁※ࢆ࠾ษࡾ࡟
࡞ࡿ࠿ࠊ࣐ࢼ࣮࣮ࣔࢻ࡟タᐃࡋ࡚ࡃࡔࡉ࠸ࠋ
㸲㸬ㅮ₇఍ሙ࡟࠾ࡅࡿ෗┿᧜ᙳ࣭ື⏬᧜ᙳࡲࡓࡣ㘓㡢࡞࡝ࡣⴭసᶒಖㆤ࠾ࡼࡧಶ
ே᝟ሗಖㆤࡢほⅬ࠿ࡽࠊ஦๓࡟Ꮫ఍㛗࡟チྍࢆᚓࡓሙྜ௨እࡣ⚗Ṇࡉࡏ࡚࠸ࡓࡔࡁࡲࡍࠋ
㸳㸬࣐ࢫࢥ࣑ྲྀᮦ࡟࠶ࡓࡗ࡚ࡣࠊ஦ົᒁ࡬ࡢ஦๓チྍ⏦ㄳࢆᚲせ࡜ࡋࡲࡍࠋᙜ᪥
ࡢྲྀᮦ⏦㎸ࡳࡣ࠾ཷࡅ࡛ࡁࡲࡏࢇࠋ

㸫㸫

第20回毛髪科学研究会

プログラム

プログラム
８:00-９:00 世話人会（１Ｆ小会議室）
９:05-９:10 開会の辞
橋本 隆（久留米大）
９:10-10:40 ミニシンポジウム
座長：西村栄美（東京医歯大）

講演Ⅰ Dr. Oh-Sang Kwon
(Department of Dermatology, Seoul National
University College of Medicine, Korea)
講演Ⅱ Dr. Liat Samuelov(Department of Dermatology, Tel Aviv Sourasky
Medical Center, Israel )10:40-10:50 coffee break

講演Ⅲ Dr. Jennifer E. Klöpper
(Department of Dermatology, University of Lübeck,Germany)

10:50-11:50 一般演題Ⅰ
12:00-13:30 ランチョンセミナー
座長：勝岡憲生（北里大）
共催：MSD 株式会社

13:30-13:45 coffee break

特別講演ⅠProfessor Cheng-Ming Chuong(Department of Pathology, University of Southern
California, USA )特別講演ⅡProfessor Xue Zhang(Department of Medical Genetics, McKusick-Zhang
Center for Genetic Medicine and State Key
Laboratory of Medical Molecular Biology, Instituteof Basic Medical Sciences, Chinese Academy ofMedical Sciences & Peking Union Medical College,
China )

13:45-14:00 総会
14:00-15:00 一般演題Ⅱ
15:00-16:00 一般演題Ⅲ
16:00-16:05 閉会の辞
次期会長
16:15-18:30 意見交換会(１Ｆ中会議室・小会議室)－ 7 －ηΣΏϋεΐ;θ   ˕;21.21;51   जಿȇୌఆ‫ו‬๼Ȫ൐‫֓ނ‬ভఱȫ !
࣒‫׵‬ԅȪ˕;21Ƚ˕;51ȫ!

Hair Growth-Promoting Effects of Adiponectin
Dr. Oh-Sang Kwon
(Department of Dermatology, Seoul National University College of Medicine,
Korea)

࣒‫׵‬ԆȪ˕;51Ƚ21;21ȫ!

P-cadherin is a Novel Key Player in the Control of Human Hair
Growth and Pigmentation
Dr. Liat Samuelov(Department of Dermatology, Tel Aviv Sourasky Medical Center, Israel)࣒‫׵‬ԇȪ21;21Ƚ21;51ȫ!

The Role of Tfam in Murine Hair Follicle Development
Dr. Jennifer E. Klöpper
(Department of Dermatology, University of Lüebeck, Germany)㸫㸫

ρϋΙοϋΓη΢Ȝ    23;11.24;41   जಿȇੳ‫࠻ؖ‬୆Ȫཤၖఱȫ!
‫ވ‬टȇ˩˯ˠ‫ڼ‬৆ٛ২! !
!
අ༆࣒‫׵‬ԅȪ23;11Ƚ23;56ȫ!

Environment and Epigenetic Regulation of Hair Stem Cell
Regeneration
Professor Cheng-Ming Chuong(Professor, Department of Pathology, University of Southern California, USA)අ༆࣒‫׵‬ԆȪ23;56Ƚ24;41ȫ!

Our Genetic Findings in Hair Growth Disorders
Professor Xue Zhang(Professor and Chairman, Department of Medical Genetics, McKusick-Zhang
Center for Genetic Medicine and State Key Laboratory of Medical Molecular
Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences& Peking Union Medical College, China)㸫㸫

๊֚‫׵‬ఴԅ   21;61.22;61   जಿȇઐॄ ܲȪോआఱȫ!
ೠ֔ၻহȪ൐‫֓ނ‬ఱȫ!
ˍȅΪΠΰͺΉρΙϋಎ‫ࠂۼ‬έͻριϋΠࠁ଼අ଻͈ٜଢ଼!
ᮏ⏣⿱Ꮚ㸪Ⲩᕝ཭㈗㸪Ᏻ⸨⚈ྖ㸪ᑠụㅬ㐀㸪ᡂ⃝ ᐶ㸪ቑᏊ㈆ᙪ
బ㈡኱ ⏕యᵓ㐀ᶵ⬟࣭⓶⭵ 㸪ᓫᇛ኱ ᛂ⏝ᚤ⏕≀ 㸪ⰼ⋤BC◊ˎȅMED1͉࿉༫ۚळ༾͈୓গેఠ̤͍͢ୃુ̈́࿉ਔ‫֋͈ܢ‬঵ͅຈါ̜́ͥ!
୰ᓥṊஅ㸪஝ 㔜ᶞ㸪అぢ▱ᾈ㸪㔝ཱྀྐே㸪໭ᕝ ᐶ㸪Janardan K. Reddy㸪ᯈぢ ᬛ኱㜰኱ ⓶⭵࣭ẟ㧥෌⏕㸧㸪Department of Pathology, Northwestern University, USAˏȅ૗ளۚळ༾͈‫ેا଻ڰ‬ఠ͂֋঵‫!ࢹܥ‬ୖ㔝┿⣖Ꮚ㸪㟷ᡞ㝯༤㸪すᮧᰤ⨾⋊༠་኱㉺㇂⑓㝔 ⓶⭵㸧㸪ᮾி་ṑ኱ ⓶⭵ 㸪ᮾி་ṑ኱㞴἞⑌ᝈ◊✲ᡤᖿ⣽⬊་Ꮫ ːȅFGF5șFGF5͈อ࡛ଷࢄͅ‫خͥͩ۾‬ෝ଻̞̾̀ͅ!
ஂ⡿㐩ஓ㸪⊦ཎ⠇அ௓㸪ᯇᓮ ㈗ᓥ᰿኱ 㝔࣭⏕≀㈨※ 㸪ᓥ᰿኱ ⏕≀㈨※ ˑȅ࿉༫ۚळ༾ႀ֖ဇြ͈ఉ໦‫ا‬ෝͬခ̳ͥۚळ༾͈ఱၾ໦ၗ༹͂ठ୆֓ၷ͈͒
ႉ઄؊ဥ!
ኳ⩚ᗣஅ㸪୕஭⣧㞷㸪Ᏻ⸤Ⰻ୍㸪Robert M. Hoffman㸪຾ᒸ᠇⏕໭ 㔛 ኱  ⓶ ⭵ 㸪 AntiCancer, Inc. 㸪 Department of Surgery, University ofCalifornia San Diego, USA㸫㸫๊֚‫׵‬ఴԆ   25;11.26;11   जಿȇโࡉ ౺Ȫఱिఱȫ!
૯ණ ‫ݥ‬Ȫਝനఱȫ!
˒ȅ‫౎ࠁ׫߿࣐ૺ௸ݢ‬࿉છ͈ൡࠗ‫ڠ‬എٜଢ଼!
ෆᒣ┿ᶞ㸪Ụⲡᬛὠ㸪ಖẕᙬᏊ㸪ධ⃝ுྜྷ㸪ᒣ㷂ṇど㸪ᆤ஭Ⰻ἞ᮾி་኱ ⓶⭵㸧˓ȅ౳଻߿౎࿉છ͈ૺ࣐ഽ͂๬ྖȂࠬգȂࠬൠȂডৗ͈‫۾‬Ⴒ଻!
ᑠᒣኴ㑻㸪ᑠᯘ୍ᗈ㸪⬥ᆏ㛗⯆㸪ᖹᒣಙኵ㸪ᑠすࡉࢃᏊ㸪୰⁁៞⏕㸪Ṋ⏣ඞஅ㸪ᕝୖṇஓᇛすࢡࣜࢽࢵࢡ㸪⬥ᆏࢡࣜࢽࢵࢡ኱㜰㸪AACࢡࣜࢽࢵࢡྡྂᒇ㸪ᇛすࢡࣜࢽࢵࢡ⚟ᒸ㸪NPO Future Medical Laboratory˔ȅࠄᑄ݅ੂఱ‫ڠ‬ພ֭๧ໂ‫ش‬࿉ฯ‫ٸ‬ြ̤̫ͥͅ౎࿉છহၷ͈࡛ે!
㇏ᓥ 㐍㸪ᒸ⏣⤮⨾Ꮚ㸪⣽ᕝ൉Ꮚ㸪Ọᑿ㤶Ꮚ㸪኱ᒣ Ꮫ៞᠕኱ ⓶⭵㸧˕ȅਜ਼ഛ൴ఱ‫ڠ‬๧ໂ‫౎ࠁ׫̫̤ͥͅش‬࿉છ͈಺औ!
లˎ༭ȇౣ‫ܢ‬হၷ಺औ!
ᆏᮏ ῟㸪ᑠฟ⣧Ꮚ㸪㧗ᮌ ᩔ㸪໭ᮧዉ⥴㸪኱᭶ளᕼᏊ㸪㎸ᒣᝋᏊ㸪ụ⏣ᚿᩦ㡰ኳᇽ኱ ⓶⭵ 

21ȅSystemic Growth Factor Treatment of the Patients with Androgenetic Alopecia
and Alopecia Areata: Preliminary Study
Byung In Ro, Shin Han Kim, Sang Yoon Lee, Hyun-Ok Son
Department of Dermatology, Myongji Hospital, Kwandong University College ofMedicine, Korea
㸫㸫๊֚‫׵‬ఴԇ   26;11.27;11   जಿȇչ൥ٗડȪ૧‫ګ‬ఱȫ!
଼ᚧ ۘȪऎٖఱȫ!
22ȅTwo Cases of Alopecia Areata in Infants
Byung In Ro, Sang Yoon Lee, Shin Han Kim, Jae Wan Go
Department of Dermatology, Myongji Hospital, Kwandong University College ofMedicine, Korea

23ȅ‫౎ࠁ׫‬࿉છͅచ̳ͥΑΞυͼΡΩσΑၷ༹ ুহ֓ఱ̯̞̹֓͘ၷΓϋΗȜঔ࣐႕͈࠿൦!
ᒣ⏣᭸Ꮚ㸪ሯཎ⌮ᜨᏊ㸪୰ᮧ⪃ఙ㸪㣤⏣⤮⌮㸪ྜྷ⏣㱟୍㸪୰ᮧဴྐ㸪ᱵᮏᑦྍ㸪ṇᮌ┿⃈㸪ຍ಴஭┿ᶞ㸪ฟගಇ㑻 ⮬἞་኱ࡉ࠸ࡓࡲ ⓶⭵㸧24ȅCronkhite-Canadaછ࢓߲̤̫ͥͅ౎࿉͈ພၑழ૕‫ڠ‬എ࠿൦!
ᒸ⏣⤮⨾Ꮚ㸪⏣୰ிᏊ㸪✄✚㇏Ꮚᯇᕝⱥᙪ኱ᒣ Ꮫ៞᠕኱㸦⓶⭵㸧㸪ᅜᐙබົဨඹ῭❧ᕝ⑓㝔 ⓶⭵㸪ᾘෆ㸧

25ȅBjörnstadછ࢓߲͈ˍ႕!
ᰗୗṊኈ㸪ఀᮾ៞Ꮚ㸪୸ᶫభᇶ㸪⏣ཱྀᬸᙪ㸪☾㒊 ‶㸪Ώ㎶኱㍜ឡ▱་኱ ⓶⭵㸧㸪࣮࣮࣍ࣘ⥲ྜ◊

26ȅࠬಎՏ‫؀‬౵̦೩౵ͬা̱̹͍ͭ͘଻౎࿉ȇΰς΋Ψ·ΗȜ࣭άυς͈͂‫۾‬Ⴒ̞̾̀ͅ!
㎞ᓥṇᚿ㸪ྂᮧ༡ኵ㸪ᶫᮏ 㝯 ஂ␃⡿኱ ⓶⭵㸧㸫㸫

抄録

ランチョンセミナー
特別講演Ⅰ
Environment and Epigenetic Regulation of Hair Stem Cell Regeneration
Professor Cheng-Ming ChuongDepartment of Pathology, University of Southern California, USA

Skin appendages such as hairs are unique in that they regenerate under physiologicalconditions, and can respond to physiological cues to morph into different shapes ofappendages, even in the sam follicle. Here we explore the regulatory mechanism.
Environmental Control: The hair follicle undergoes cyclic degeneration and regeneration
cycle throughout life. The length of growing (anagen) and resting phase (telogen) can
determine the hair length. Long resting phase mean shorter or no hair, i.e., alopecia. We
developed ways to visualize hair stem cell activation in living mice and, with this new assay,
found BMP and wnt, work as a pair of inhibitor / activator to regulates hair stem cell
activation (Plikus et al. 2008, 2011). We show change in macro-environment is one major
factor that contributes to alopecia. We try to target macro-environment for therapy bystimulating resting follicles to re-enter growing phase.
Epigenetic control: To examine the roles of epigenetic modulation on hair follicle
regeneration, we generated mice with a K14Cre-mediated loss of DNA methyltransferase(DNMT) 1. Mutants with K14 mediated DNMT depletion show an uneven epidermal
thickness and alterations in hair follicle size. When formed, hair follicle architecture anddifferentiation appear normal. Hair subtypes exist but hair fibers are shorter and thinner. Hair
numbers appear normal at birth but gradually decrease in old mice. As mice age, residual
DNMT activity declines further and the probability of successful anagen reentry decreases,
leading to progressive alopecia.

－ 13 －

ランチョンセミナー
特別講演Ⅱ
Our Genetic Findings in Hair Growth Disorders
Professor Xue Zhang
Department of Medical Genetics, McKusick-Zhang Center for Genetic Medicine and StateKey Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese
Academy of Medical Sciences & Peking Union Medical College, China
Hair growth disorders have been associated with mutations in many genes functioning inmorphogenesis, cycling, differentiation and homeostasis of hair follicles. Usually themutations are detected in the coding regions of the causative genes. For example,
loss-of-function mutations in the hairless gene (HR) cause atrichia with popular lesions(APL, OMIM 209500). We have identified mutations in U2HR, an upstream open reading
frame (uORF) of the HR transcript, in Marie Unna hereditary hypotrichosis (MUHH, OMIM
146550). Further functional analysis showed that these mutations resulted in increasedtranslation of the main HR physiological ORF, thus leading to a gain-of-function effect ofHR.
Congenital generalized hypertrichosis (CGH) is the major phenotypic feature of many
distinct genetic syndromes and can be inherited as an autosomal or X-linked dominant trait.
We have identified copy number variations (CNVs) on chromosome 17q24 near SOX9 incongenital generalized hypertricosis terminalis with or without gingival hyperplasia (OMIM
135400), an autosomal dominant form of CGH. In X-linked CGH syndrome (OMIM
307150), we have found independent autosomal insertions into the same Xq27.1 site. Our
further genomic analysis demonstrated that the insertions are mediated by the same
human-specific short palindromic sequence located 82 kb downstream of SOX3. Together,
our results establish CGH as a genomic disorder.
Pure hair and nail ectodermal dysplasia (PHNED, OMIM 602032) is an autosomal recessive
condition characterized by hypotrichosis and nail dystrophy. In collaboration with Prof.
Yong Yang at Peking University First Hospital, we have identified independent
loss-of-function mutations in HOXC13 in patients affected with PHNED.

－ 14 －

ミニシンポジウム
講演Ⅰ
Hair Growth-Promoting Effects of Adiponectin
Dr. Oh-Sang Kwon
Department of Dermatology, Seoul National University College of Medicine, Korea

Adipose tissue (AT) is no longer considered just an inert energy storage organ but is also
known to be involved in active regulation of physiological and pathological processes. AT
produces and releases a variety of factors called adipokines, including the well-known
adiponectin. The aim of this study was to evaluate the effect of adiponectin on human hairfollicles (HFs) in vitro. Human anagen HFs were isolated and cultured, and then treated withadiponectin. The proliferation of dermal papilla (DP) cells increased with adiponectin
treatment. In addition, in ex vivo organ culture, dose-dependent hair shaft elongation wasobserved in the presence of adiponectin. Moreover, we noted that adiponectin treatment
significantly increased the expression of IGF-1, HGF, and VEGF mRNAs in DP cells.
Furthermore, adiponectin-induced proliferation of follicular DP cells (DPCs) was
significantly reduced by treatment with VEGF and IGF-1 siRNAs. These in vitro results
indicate that human HF is a direct target of adiponectin and that adiponectin may stimulate
hair growth by increasing the secretion of IGF-1, HGF and VEGF from DPCs.

－ 15 －

２
MED1は毛包幹細胞の静止状態および正常な毛周期の維持に必要である
Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenanceof Normal Hair Cycling
中島武之 1，乾板見
1

重樹 1，伏見知浩 1，野口史人 1，北川寛 1，Janardan K. Reddy2，

智1

大阪大（皮膚・毛髪再生）， 2Northwestern大（病理）Takeshi Nakajima1, Shigeki Inui1, Tomohiro Fushimi1, Fumihito Noguchi1,
Yutaka Kitagawa1, Janardan K. Reddy2, Satoshi Itami1
1

Departmant of Regenerative Dermatology, Osaka University, 2Department of Pathology,

Feinberg School of Medicine, Northwestern University, USA

MED1は転写因子の共役因子（co-activator）である。我々は表皮特異的Med1ノックアウトマウス（Med1epi-/-）を作成し解析した。Med1epi-/-では生後６ヶ月間は野生型よりも頻回に毛周期を繰り返したが、６ヶ月を超えると休止期にとどまり疎毛となった。組織学的にMed1epi-/- では毛包間表皮での表皮肥厚が認められた。一方、Med1epi-/- では生後２ヶ月頃から毛包幹細胞数が減少していた。以上の結果から、MED1は毛包幹細胞からの過剰な細胞の供給を抑制する役割があると考えられた。
MED1 functions as a coactivator of several transcription factors. We establishedkeratinocyte-specific Med1-null (Med1epi-/-) mice. The hair cycle of Med1epi-/- mice
was spontaneously repeated after the second telogen, which does not occur inwild-type mice. Hair follicles of Med1epi-/- mice could not enter anagen after 6 monthsof age, resulting in sparse pelage hair in older Med1epi-/- mice. Interfollicular epidermisof Med1epi-/- mice was acanthotic than that of wild-type mice. The numbers of hairfollicle bulge stem cells were reduced in Med1epi-/- mice from a few months after birth.
These results suggested that MED1 plays roles in maintaining quiescence of
keratinocytes and preventing depletion of the follicular stem cells.

－ 20 －

３
色素幹細胞の活性化状態と維持機構
Activation and Maintenance of Melanocyte Stem Cells
上野真紀子 1,2,3，青戸隆博 3，西村栄美 31獨協医大越谷病院(皮膚）， 2東京医歯大(皮膚)，3

東京医歯大難治疾患研究所(幹細胞医学)

Makiko Ueno1,2,3, TakahiroAoto3, Emi K. Nishimura3
1

Department of Dermatology, Dokkyo Medical Univ. Koshigaya Hospital, 2Departmentof Dermatology, Tokyo Medical and Dental University, 3Department of Stem Cell Biology,
Medical Research Institute, Tokyo Medical and Dental University

色素幹細胞は、毛周期ごとに自己複製すると同時に分化した色素細胞を供給している。しかし、加齢やゲノムストレスによりその未分化性を失うと枯渇し、成熟した色素細胞が不足する結果、白髪が誘導される。今回、我々は色素幹細胞を安定的に可視化する系を作成し、色素幹細胞が均一な細胞集団かどうか放射線照射への反応性を調べたところ、活性化状態と非活性化状態の細胞集団が存在し、それぞれ異なる感受性を示すことが判明した。

－ 21 －

４
FGF5sがFGF5の発現制御に関わる可能性について
Possible Roles of FGF5s in Regulation of FGF5 Expression
久米達也 1，猪原節之介 2，松崎1

貴2

島根大(院・生物資源)， 2島根大(生物資源)

Tatsuya Kume1, Setsunosuke Ihara2, Takashi Matsuzaki2
1

Course of Biological Science and Biotechnology, Graduate School of Life andEnvironmental Science, Shimane University, 2Department of Biological Science,
Faculty of Life and Environmental Science, Shimane University.

毛周期の調節に関わるFGF5の選択的スプライシング産物のFGF5sについては不明なことが多い。そこで、マウス由来細胞にヒト由来FGF5とFGF5s遺伝子を導入し、Q-PCRで両遺伝子の発現量を調べた。その結果、不思議なことにFGF5s遺伝子の導入量に依存してFGF5の発現が上昇した。これは、FGF5sの高発現により、FGF5 mRNAの分解が抑制された結果、見かけの発現量が増加したものと考えられる。
It is still unknown what are the roles of FGF5s, ashort splicing variant of FGF5 thatis
known to be involved in regulation of catagen induction. We had transfected mice
fibroblasts with Lenti-virus vectors carrying FGF5 and/or FGF5s and then examined
the mRNA expression levels by Q-PCR. Curiously, the expression of FGF5 mRNA
increased depending on the amount of FGF5s gene that had been introduced into thecells,although the amount of transfected FGF5 gene is the same. This fact suggeststhat the expression of FGF5s could inhibit the degradation of FGF5 mRNA and resultin its deposition.

－ 22 －

５
毛包幹細胞領域由来の多分化能を有する幹細胞の大量分離法と再生医療への臨床応用High-Throughput Production of Hair-Follicle Nestin-expressing Stem Cells
for Regenerative Medicine
天羽康之 1，三井純雪 1,2,3，安藝良一 1，Robert M. Hoffman2,3，勝岡憲生 11

北里大（皮膚）Yasuyuki Amoh1, Sumiyuki Mii1,2,3, Ryoichi Aki1, Robert M. Hoffman2,3,Kensei Katsuoka1
1

Department of Dermatology, Kitasato University School of Medicine, 2AntiCancer,

Inc., 3Department of Surgery, University of California San Diego, USA

我々は、ネスチンを発現する毛包幹細胞領域を血清含有培地で一度増殖させてから幹細胞培養液に戻す方法を用いて、多分化能を有する幹細胞コロニーを大量に培養する手法を開発した。本法を用いて分離した細胞は、毛包幹細胞領域
から純粋分離した幹細胞と同様の多分化能と損傷神経を強力に再生する能力を有していた。本研究は毛包幹細胞による再生医療の臨床応用に向けた一歩になると考えられる。

－ 23 －

６
急速進行型円形脱毛症の統計学的解析
Statistical Analysis of Prognostic Factors in Patients with Rapidly
Progressive Alopecia Areata
内山真樹，江草智津，保母彩子，入澤亮吉，山﨑正視，坪井良治
東京医大（皮膚）Masaki Uchiyama, Chizu Egusa, Ayako Hobo, Ryokichi Irisawa , Masashi Yamazaki,
Ryoji Tsuboi
Department of Dermatology, Tokyo Medical University

円形脱毛症（以下、AA)の予後を決定する因子は明らかではない。我々は過去３年間に受診した1030例について患者・治療因子の予後への影響を解析し、特に、初診時より６ヵ月以内に全頭の広範囲にわたって易脱毛性を認めた症例を
急速進行型AA（以下、RPAA）と定義し、多変量解析した。新生軟毛陽性群は、改善率と治癒率が高く、若年発症群と罹患期間長期群は、治癒率が低く、再発率が高かった。また、RPAA群は予後がよい因子であった。
Alopecia areata (AA) is a common acquired hair disorder showing variable hair loss.
Although various prognostic factors have been reported, no evident factors fordetermining prognosis and appropriate treatment are known. To identify prognostic
factors in AA patients, especially those with positive results for the hair-pull test on
the first visit or with a history of rapidly progressive AA (RPAA) within 6 months
prior to the first visit, 1,030 patients diagnosed with AA at Tokyo Medical University
Hospital were retrospectively examined for three years, and their prognosis wasassessed on the basis of various indices using multivariate analysis. Patients withregenerated vellus hairs showed a significantly higher improvement or cure rate
regardless of severity. Early onset and lengthy duration were significantly associatedwith lower cure, and higher relapse, rates. RPAA patients tended to show a good
prognosis regardless of the treatment employed.

－ 24 －

７
男性型脱毛症の進行度と肥満、血圧、血糖、脂質の関連性
Association of Androgenetic Alopecia with Obesity, Hemoglobin A1c,
Low-Density Lipoproteincholesterol, Alanine Transaminase,Gamma-glutamyltranspeptidase and Systolic Blood Pressure: Clinic-based
Survey in Japan
小山太郎 1，小林一広 1，脇坂長興 2，平山信夫 3，小西さわ子 4，中溝慶生 4，武田克之 5，川上正也 51

城西クリニック， 2脇坂クリニック大阪， 3AACクリニック名古屋，

4

城西クリニック福岡， 5 NPO Future Medical Laboratory

Taro Koyama1, Kazuhiro Kobayashi1, Nagaoki Wakisaka2, Nobuo Hirayama3,
Sawako Konishi4, Yoshio Nakamizo4, Katsuyuki Takeda5, Masaya Kawakami5
1

Josai Clinic, 2 Wakisaka Clinic Osaka, 3 AAC Clinic Nagoya, 4 Josai Clinic Fukuoka,

5

NPO Future Medical Laboratory

欧米の疫学研究では高血圧、脂質代謝異常、インスリン抵抗性と男性型脱毛症（以下AGA）との関連性の報告が散見される。我々は2664人の日本人男性（16歳～72歳）を対象にAGA進行度と種々の因子との関連性を解析した。多変量ロジスティック回帰を用いて全因子で調整を行ったところ、年齢、肥満、HbA1c、
LDL-コレステロール、ALT、γGTP、収縮期血圧、父親の薄毛とAGA進行度との関連性が確認された。
Introduction: Hypertension, dyslipidemia, and insulin resistance have been reported to
be associated with androgenetic alopecia (AGA). However the results of studies show
inconsistent results.

Methods: A clinic-based cross-sectional survey was conductedin Japan. The total of subjects was 2,664 men aged 16-72 years. After exclusion ofsubjects with incomplete data, 1,873 men were analyzed with multivariate logistic
regression to assess the association between AGA evaluated by modified
Hamilton-Norwood classification (* I-III vs IV-VII, ** I-III vs IIIv-VII, *** I-IIIv vsIV-VII) and various characteristics, such as, family history of hair loss, smoking
history, alcohol intake, hemoglobin A1c (HbA1c), blood pressure, body mass index(BMI), low-density lipoprotein cholesterol (LDL-C), high-density lipoproteincholesterol, uric acid and hepatic function including alanine transaminase (ALT),－ 25 －

aspartate amino transferase

and gamma-glutamyl transpeptidase (gamma-GTP).

Results: Statistically significant associations (p<0.05) were found between AGA andthe following factors with multivariate logistic regression: age (10-year increase)[odds ratio (OR) 2.759*, 2.145**, 2.012***, 95% confidence interval (CI)2.343-3.248*, 1.855-2.481**, 1.799-2.249***], father hair loss [OR 1.473*, 1.364**,1.344***/ 95% CI 1.138-1.907*, 1.090-1.707**, 1.100-1.643***], BMI 25+ [OR
2.566*, 2.031**, 1.950***/ 95% CI 1.709-3.854*, 1.390-2.968**, 1.478-2.578***],
HbA1c 5.2%+ [OR 1.949*, 95% CI 1.047-3.629*] , LDL-C 120 mg/dL+ [OR 1.380**,
95% CI 1.073-1.781**], ALT 31 IU/l+ [OR 1.585*, 1.396***/ 95% CI 1.159-2.168*,
1.109-1.757***], gamma-GTP 50 IU/l+ [OR 1.555**, 95% CI 1.082-2.235**] andsystolic blood pressure 130 mmHg+ [OR 1.301***, 95% CI 1.034-1.636***] .
Conclusion: The proposed study demonstrates the association of AGA with obesity,
HbA1c, LDL-C, ALT, gamma-GTP and systolic blood pressure in Japanese males.

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８
慶應義塾大学病院皮膚科毛髪外来における脱毛症治療の現状
The Present Situation of the Hair Disease Clinic in Keio University
Hospital: Especially Focusing on the Treatment of Alopecia Areata and its
Outcome豊島進，岡田絵美子，細川僚子，永尾香子，大山学

慶應大（皮膚）Susumu Toshima, Emiko Okada, Ryoko Hosokawa, Kyoko Nagao, Manabu Ohyama
Department of Dermatology, Keio University School of Medicine

当院毛髪外来のうち最も受診数の多い外来枠の現状を調査した。患者の男女比は約1:2.3、30代以下が６割以上を占めた。円形脱毛症が８割以上。2:2:1の割
合でステロイド局注、局所免疫療法、ステロイド内服が選択されていた。罹患
面積Ｓ１～３の患者では局注、Ｓ４、５の患者では局所免疫療法、ステロイド
内服例が多く、治療法に応じて約45％～70％の症例で改善がみられていた。他
施設の報告と現状を比較検討した。
The present situation of the hair disease clinic in Keio University Hospital wasinvestigated. The ratio of males and females was approximately 1:2.3. Those under theage of 30 accounted for more than 60% of all cases. More than 80% of the patients had
alopecia areata. These patients were mostly treated with local injection and/or oral
administration of corticosteroid or contact immunotherapy. The patients with theaffected area classification S1-3 were mostly treated with steroid local injection, while
S4-5 cases were treated with contact immunotherapy or systemic corticosteroid. The
response rates were around 45-70% depending on the treatment applied. The
characteristics of our clinic were compared with those of other institutes in theliterature.

－ 27 －

９
順天堂大学皮膚科における円形脱毛症の調査
第２報：短期治療調査
Survey of Alopecia Areata Seen at Juntendo University Hospital,
Part2 Short-term Treatment Study
坂本淳，小出純子，高木敦，北村奈緒，大月亜希子，込山悦子，池田志斈

順天堂大（皮膚）Atsushi Sakamoto, Junko Koide, Atsushi Takagi, Nao Kitamura, Akiko Otsuki,
Etsuko Komiyama, Shigaku Ikeda
Department of Dermatology, Juntendo University

2010年２月～７月までの半年間に初診として当科外来受診した円形脱毛症患者397例を対象に調査を行った。男女比は1:1.4、臨床学的分類は単発型111例(27.9％）、多発型233例（56.1％）、全頭型24例（６％）、汎発型29例（7.3％）。
アトピー性皮膚炎の合併は46例（11.6％）。アトピー疾患を合併している方が病型別に関わらず難治例の頻度が高く、半年間の調査ではステロイド内服、ステロイド局所注射の有効性は高かったが長期治療効果についても検討が必要である。

－ 28 －

10
Systemic Growth Factor Treatment of the Patients with Androgenetic
Alopecia and Alopecia Areata: Preliminary Study
Byung In Ro, Shin Han Kim, Sang Yoon Lee, Hyun-Ok Son
Department of Dermatology, Myongji Hospital, Kwandong University College ofMedicine, Korea

New treatments of alopecia, such as mesotherapy, platelet-rich plasma (PRP) injection
is now performed as treatment options in clinical fields. Among the various stimulants,
growth factor is known as the most effective agent in hair regeneration.
Systemic growth factor (SGF 57) is composed of β-fibroblast growth factor (β-FGF),
vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1),
keratinocyte growth factor (KGF), stem cell factor (SCF), noggin, Cu/Zn superoxide
dismutase (SOD) and multi-nutrients. Intralesional injection of SGF in the scalp of thepatients with alopecia was performed by Derma-S device through trans-epidermal
electrophoresis.
Eleven months (from October 2011 to August 2012), 295 patients with androgenetic
alopecia and alopecia areata were treated by SGF injection in 2~4weeks interval.
Inclusion criteria was androgenetic alopecia, alopecia areata (including totalis anduniversalis), telogen effluvium and trichotillomania. Treatment response was
evaluated by phototrichogram and digital photograph in every 3 to 6 months.
Herein, we report the efficacy of SGF intralesional injection to the patients withandrogenetic alopecia, alopecia areata and other alopecia disease.

－ 29 －

11
Two Cases of Alopecia Areata in Infants
Byung In Ro, Sang Yoon Lee, Shin Han Kim, Jae Wan Go
Department of Dermatology, Myongji Hospital, Kwandong University College ofMedicine, Korea

Alopecia areata (AA) is a common cause of non-scarring hair loss in childhood.
Pathogenesis of AA is unknown, but is related with autoimmune diseases andpsychological stress. However, AA has been reported to be extremely rare in young
infants.
Causes of neonatal and infantile AA are associated with various conditions. Perinatal
trauma associated with caput succedaneum (pressure-induced alopecia), physiologic
hair loss of telogen hairs on the occipital scalp, physical trauma associated withchronic friction (pressure over the bony occipital prominence), and other conditions(congenital triangular alopecia, congenital nevus) may be contributing to the hair loss.
Early onset of hair loss in infant is associated with many diseases, which may berequired to careful consideration.
We report two interesting cases of alopecia areata in young infant less than 6 monthold (2 month old boy and 4 month old boy).

－ 30 －

12
円形脱毛症に対するステロイドパルス療法
ター施行例の検討

自治医大さいたま医療セン

Analysis of the Cases of Alopecia Areata Treated with Steroid Pulse
Therapy at Jichi Medical University Saitama Medical Center
山田朋子，塚原理恵子，中村考伸，飯田絵理，吉田龍一，中村哲史，梅本尚可，
正木真澄，加倉井真樹，出光俊郎
自治医大さいたま（皮膚）Tomoko Yamada, Rieko Tsukahara, Toshinobu Nakamura, Eri Iida, Ryuichi Yoshida,
Satoshi Nakamura, Naoka Umemoto, Masumi Masaki, Maki Kakurai, Toshio Demitsu
Department of Dermatology, Jichi Medical University Saitama Medical Center

2007年10月から2012年８月までに円形脱毛症39症例（17歳から81歳までの、男性19名、女性20名）に対し、ステロイドパルス療法を計43回施行した。３ヶ月以上観察できた34症例のうち、 19症例（55.9％）は良好な経過をとった。１例
のみアナフィラキシー様症状がみられたが、その他は有害事象はみられなかった。本法は有害事象の発生率が低く、簡便に施行できて有効な治療法であると考えた。

－ 31 －

13
Cronkhite-Canada 症候群における脱毛の病理組織学的検討
Hair Loss in Cronkhite-Canada Syndrome: a Clinicopathological Study of
Two Cases
岡田絵美子 1,2，田中京子 2，稲積豊子 2，松川英彦 3，大山
1

学1

慶應大（皮膚）， 2国家公務員共済立川病院（ 2皮膚， 3消内）E.Okada1,2, K. Tanaka2, T. Inazumi2, H. Matsukawa3, M. Ohyama1
1

Department of Dermatology, Keio University School of Medicine, Divisions of2

Dermatology and 3Gastroenterology, Federation of National Public Service Personnel

Mutual Aid Associations Tachikawa Hospital
Cronkhite-Canada症候群では脱毛がほぼ必発だが、過去の病理組織学的記述は不完全であった。今回我々は、脱毛の程度が異なる２症例の頭皮生検標本を定量的に解析した。脱毛の進行の程度に関係なく毛包数は正常、炎症所見やミニチ
ュア化はなかった。休止期毛が８割以上を占めた。以上より受診時毛髪の残る症例でも広範な脱毛は避けられないが消化管病変の治療により完全な再発毛が期待できることが示唆された。

Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by gastrointestinal
polyposis and ectodermal changes. Alopecia represents common CCS symptoms,
however, the pathophysiology has not been satisfactorily studied. To provide deeper
insights, quantitative histopathological analysis of the lesions was made in two female
CCS cases with respective hair loss severities. Total hair follicle numbers were normal
and miniaturization/atrophy of hair follicles were not detected. Telogen hair follicles
accounted for more than 80% of total hair follicles irrespective of the severity of hairloss. Those histopathological findings are compatible with acute telogen effluvium.
Thus, progressive hair loss is inevitable once any sign of hair loss was noticed in a
CCS patient. However, the complete hair regrowth can be expected once thegastrointestinal involvement is well managed.

－ 32 －

14
Björnstad症候群の１例
A Case of Björnstad Syndrome
柳下武士 1，伊東慶子 1，丸橋佑基 2，田口暢彦 2，磯部満 2，渡辺大輔 11

愛知医大（皮膚）， 2ホーユー総合研

Takeshi Yanagishita1, Keiko Ito1, Yuki Marubashi2, Nobuhiko Taguchi2,
Mitsuru Isobe2, Daisuke Watanabe1
1Department of Dermatology, Aichi Medical University School of Medicine

2

General Research and Development Institute, Hoyu Co., Ltd.

症例は２歳３ヶ月の女児。１歳半検診で言語発達遅延を指摘され当院耳鼻科で高度の感音性難聴と診断。生後３ヶ月頃より頭髪が少ないことに両親が気づき
当科受診した。頭髪は全体に短く疎毛を認める。毛髪の光顕、電子顕微鏡観察
で捻転毛を認め、一部に裂毛を生じていた。感音性難聴と捻転毛の合併から
Björnstad（ブヨルンスタッド）症候群と診断した。本疾患は本邦２例、海外39例しか報告されておらず、稀な疾患である。

A 2 years and three months old Japanese female presented with a 2-year history ofsparse hair on the head. She was indicated retarded speech development by medical
examination and diagnosed severe sensorineural deafness at otolaryngology. Physicalexamination revealed that her scalp hairs were generalized thin, sparse and differing
lengths with twist appearance. Light and scanning electron microscopy demonstrated
that her hair was classical findings of pilitorti with trichorrhexis partially. A diagnosisof Björnstad syndrome was made on the basis of these clinical findings (pilitorti withcongenital deafness). The disease has been described only thirty-nine cases in the
English literature. Herein, we report a case of Björnstad syndrome.

－ 33 －

15
血中亜鉛値が低値を示したびまん性脱毛：ヘリコバクター・ピロリとの関連についてLow Serum Zinc Level in Patients with Diffuse Hair Loss: Evaluation of
the Possible Relationship between Helicobacter Pylori Infection and Low
Serum Zinc Level in Alopecia Patients
辛島正志、古村南夫、橋本隆

久留米大（皮膚）Tadashi Karashima, Minao Furumura, Takashi Hashimoto
Department of Dermatology, Kurume University School of Medicine
我々は以前の本研究会において、びまん性脱毛を呈する症例の一部は血中亜鉛
値が低値を示し、経口亜鉛製剤の投与による亜鉛補充療法が有効であることを報告した。しかし、中には亜鉛補充療法後も血中亜鉛値が増加せず、毛髪も回復しない症例がある。これらのおよそ半数の症例はヘリコバクター・ピロリ保菌例であった。

－ 34 －

第20回毛髪科学研究会開催支援団体の御芳名と御礼
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第20回毛髪科学研究会
会長
（協

橋本

隆

賛）

ＭＳＤ株式会社
大正製薬株式会社
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2012年10月22日現在）