ClaritySuite
Collecting and learning from all
safety-relevant sources to detectand analyse drug-safety andtarget-safety associations.

ClaritySuite
A complete collection of data, signals and analytics products for exploring drug-safety
and target-safety associations and for analysing safety signals.

Clarify
Spontaneous Reports
Congress Abstracts
FAERS (USA)
VAERS (USA)ClaritySignals
SafetyJADER (Japan)
VigiBase® (World)

ClarityStrata
Drug(Aggregates)

ICSR

SafetySubpopulation Analysis
WeightTarget(Families)

VAERS

AgeVAERS
FAERS
JADER
VigiBase®

DiseaseDrug(Classes)

ClarityOne

VigiBase®

FAERS(Organs)

SexRegion

ClarityVistaJADERClarify: Safety Data System
A proprietary safety data management system to assist a team of manual curators to review
safety terms and to facilitate the product owner to produce Beta versions.

ClarityOne

Clarify

VAERS

ICSR

Spontaneous Reports
Congress Abstracts

VigiBase®

FAERS (USA)
VAERS (USA)JADER (Japan)
VigiBase® (World)

FAERS

JADER

Chemotargets’ proprietary Safety Data Management System

01. Extraction

02. Curation

03. Review

04. Authority
construct

Data is extracted

The terms that can’t beThe manually curated

from several sources,automatically mapped

terms are reviewed by

A thesaurus is createdboth structured andare manually assigned

experts before being

with the corpus of allplain text.

to a standard term

accepted.

mapped terms.

or a newly createdcustom term.

Loading Process
Pipeline

Beta Site
UploadContent AssitantManager

Load source data andUpdate source code

Manage, edit and create

manage SRSs contentand SRSs content to Beta

new help documents forloading process.

testing site.

ClarityVista.

Manual CurationAssistantReview Thesaurus
UpdatesManual Thesaurus
CommitUpload new verbatim

Review the manually

Accept newly mappedterms and facilitate theircurated terms before

raw terms as valid terms

mapping to alreadythey are accepted inin the Thesaurus.

curated terms.

the Thesaurus.

ClarityOne: One Integrated SRS
Data cleansing (deduplication), Term normalization (integration), Report labelling(deCOVIDation) of individual and integrated SRS sources.

ClarityOne

Clarify

VAERS

ICSR

Spontaneous Reports
Congress Abstracts

VigiBase®

FAERS (USA)
VAERS (USA)JADER (Japan)
VigiBase® (World)

FAERS

JADERSummary of SRS Data Contents

VigiBase

2023-06-01

2023-06-01

FAERS

35,059,763

2023-06-01

VAERS

22,232,755

2023-06-01

JADER

2,465,189

830,079

Postmarketing Reports by Year
70,000,000
60,000,000
50,000,000
40,000,000
30,000,000
20,000,000
10,000,000
0
1987

1989

1991

1993

1995

1997

1999

2001

2003

Impact of COVID on safety signals

2005

2007

2009

2011

2013

Medicinal Products

Percentage change of the number ofdetected signals (PRR05>=2), n=25 AEs

Single Drugs
60

12,97540

Vaccines

611

200

Pharmacology-20

Targets-40-60Pre-pandemic vs total

Pre-pandemic vs total corrected

2015

2017

2019

2021

2023

PreclinicalPreclinical Data

81,864

Metabolites

845
ClinicalLabel Data

5,171

167,845

Affinities

Trial Data

500,126

52,390ClaritySignals: Safety Data Feeds
Generating high quality safety alerts and signals from the most up-to-date integrated,
deduplicated and curated post-marketing spontaneous reporting systems.

ClarityOne

ClaritySignals
Safety(Aggregates)

VAERS

VigiBase®

FAERS
DiseaseDrug(Classes)

Target(Organs)(Families)

JADER

Drug (Class)Target (Family)

Safety Associations

Safety Associations

1,091,223 reported associations

7,246 reported associations(including 1,735 signals and 4,151 warnings)

between 527 target families

between 593 chemical classes andand 2,823 targets.

16,422 side effects.

4,837 reported associations

10,518,538 reported associations

between 175 target families and(including 56,489 signals and 106,569

2,648 targets.

warnings) between 4,061 drugs and22,399 side effects.

Safety Data Feed Sample
Drug Class NameSide Effect Preferred Term

Alert Level

Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors

Fungal Infection

SignalSodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors

Ketoacidosis

SignalSodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors

Urinary Tract Infection

Signal...

...

HMG-CoA Reductase Inhibitors

Muscular Weakness

SignalHMG-CoA Reductase Inhibitors

Myalgia

SignalHMG-CoA Reductase Inhibitors

Rhabdomyolysis

Signal...

...

Poly (ADP-ribose) polymerase (PARP) Inhibitors

Anaemia

SignalPoly (ADP-ribose) polymerase (PARP) Inhibitors

Haematotoxicity

SignalPoly (ADP-ribose) polymerase (PARP) Inhibitors

Platelet Count Decreased

SignalClarityStrata: Stratified Data Feeds
Generating high quality safety alerts and signals from stratified subpopulationsof patient characteristics.

ClaritySignals

ClarityStrata

SafetyDrug(Aggregates)

SafetySubpopulation Analysis
Weight
VAERS
FAERS
JADER
VigiBase®

DiseaseDrug(Classes)

Target(Organs)(Families)

Sex

Age

Sex

AgeRegion

WeightRegionFemaleNewborn

Underweight

American Region

MaleInfancy

NormalEuropean Region

Childhood

Overweight

Western Pacific Region

Adolescence

ObeseSouth-East Asia Region

Adulthood

Eastern Mediterranean

MidlifeRegion

Maturity

African Region

Retirement

Stratified Data Feed Sample
Drug NameSide Effect

Sex

AgeWeightRegion

PRR05

Aripiprazole

Dyskinesia----9.84

Aripiprazole

Dyskinesia

Male---

8.48

Aripiprazole

Dyskinesia-

Retirement

--

7.50

Aripiprazole

Dyskinesia

MaleRetirement

Underweight-

5.98

Aripiprazole

Dyskinesia

----

8.17

Aripiprazole

Dyskinesia---

Americas11.52

Aripiprazole

Dyskinesia--

Underweight

Western Pacific5.14

Aripiprazole

Dyskinesia--

Underweight

Americas

10.14

Aripiprazole

Dyskinesia--

Western Pacific

1.56

ClarityVista: Translational Safety
An integrative safety analytics platform to explore the full data contents of ClarityOne
and the knowledge graphs of ClaritySignals and ClarityStrata.

ClarityVista

ClaritySignals
ClarityOne
ClarityStrata

Facilitating the analysis of safety associations
and post-marketing surveillance
Postmarketing Signal Analysis
5121202019201820201716204ADR
ADR
SIGNAL SIGNALS

23520222220102014131ADR
ADR
ADR
ADR
ADR
ADR
SIGNAL SIGNALS SIGNALS SIGNALS SIGNALS SIGNALS

151ADR
SIGNAL

2022010092008

201ADR
ADR
SIGNAL SIGNALS

2011221112007062020050403

3201ADR
ADR
ADR
ADR
ADR
SIGNAL SIGNALS SIGNAL SIGNALS SIGNAL

201ADR
SIGNAL

2002012020009920192205ADRADR
SIGNALS SIGNALS

202ADR
SIGNALS

ClaritySuiteYour Safety Intelligence Platform

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C/Baldiri Reixac 408028, Barcelona (Spain)
info@chemotargets.com
www.chemotargets.com