3.

乾燥メカニズム関連

2023/02 現在
ナンバーが赤字表記の論文は送付可能（請求先：imokawag@dream.ocn.ne.jp）

3-1. 英語原著論文（60 報）
1. Genji Imokawa, Kikuhiko Okamoto: The effect of zinc purithione on human skin cells in
vitro. J Soc Cosmet Chem., 34,1-11, 1983
2.

Imokawa G, Hattori M: A possible function of structural lipid in the water-holding
properties of the stratum corneum. J Invest Dermatol 84: 282-284, 1985

3. Imokawa G, Akasaki S, Hattori M, Yoshizuka N: Selective recovery of deranged waterholding properties by stratum corneum lipids. J Invest Dermatol 87: 758-761, 1986.
4. Imokawa G, Zama M, Minematsu Y, Akasaki S, Kawamata A, Yano Y., Takaishi N: Selective
recovery of deranged water -holding properties in the stratum corneum by synthesized
pseudo-ceramide derivatives. Pro Jpn Soc Invest Dermatol 12: 126-127, 1988.
5. Imokawa G, Akasaki S, Minematsu Y, Kawai M: Importance of intercellular lipids inwater-retention properties of the stratum corneum: Induction and recovery study ofsurfactant dry skin.” Arch Dermatol Res 281: 45-51, 1989.
6. Imokawa G, Akasaki S, Minematsu Y, Kuno O, Zama M, Kawai M, Hattori M, Yoshizuka
N., Kawamata A., Yano Y., Takaishi N.: Function of lipids on human skin. J Disp Sci
Tech 10: 617-641, 1989.
7. Imokawa G, Akasaki S, Kawamata A, Yano S, Takaishi N: Water-retaining function in thestratum corneum and its recovery properties by synthetic pseudo-ceramides. J Soc
Cosmet Chem 40: 273-285, 1989.
8.

Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A: Decreased level ofceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic
dry skin? J. Invest. Dermatol. 96: 523-526, 1991

9. Imokawa G, Kuno H, Kawai M: Stratum corneum lipids serve as a bound-water modulator.
J. Invest. Dermatol. 96: 845-851, 1991.
10. Matsuo N, Nomura T, Imokawa G: A rapid and simple assay method for UDPglucose:ceramide glucosyltransferase. Biochim. Biophy. Acta 1116: 97-103, 1992.
11. Holleran WM, Takagi Y, Imokawa G, Jackson S, Lee JM, Elias PM: Betaglucocerebrosidase activity in murine epidermis: Characterization and localization in
relation to differentiation. J Lipid Res 33: 1201-1209, 1992.
12. Akimoto K, Yoshikawa N, Higaki Y, Kawashima M, Imokawa G: Quantitative analysis ofstratum corneum lipids in xerosis and asteatotic eczema. J Dermatol (Tokyo) 20: 1-6,

1993.
13. Yoshikawa N, Imokawa G, Akimoto K, Higaki Y, Jin K, Kawashima M: Regional analysis
of ceramides within the stratum corneum in relation to seasonal changes. Dermatology
188: 207-214, 1993.
14. Imokawa G, Yada Y, Higuchi K, Okuda M, Ohashi Y, Kawamata A: Pseudo-acylceramide
with linoleic acid produces selective recovery of diminished cutaneous barrier functionin essential fatty acid deficient rats and has an inhibitory effect on epidermal hyperplasia.
J Clin Invest 94: 89-96, 1994.
15. Jin K、Higaki Y, Takagi Y, Higuchi K, Yada Y, Kawashima M, Imokawa G: Analysis of
Beta-glucocerebrosidase and ceramidase activity in atopic and aged dry skin. Acta DermVenereol 74: 337-340, 1994.
16. Jokura T, Ishikawa Y, Tokuda H, Imokawa G: Molecular analysis of elastic properties ofthestratum

corneumbysolid-state

13C-nuclear

magnetic

resonance

spectroscopy. J Invest Dermatol 104: 806-812, 1995.
17.

Yada Y, Higuchi K, Imokawa G: Purification and biochemical characterization of
membrane-bound epidermal ceramidase from guinea pig skin.

J. Biol. Chem. 270:

12677-12684, 1995.
18. Murata Y, Ogata J, Higaki Y, Kawashima M, Yada Y, Higuchi K, Tsuchiya T, Kawaminami
S, Imokawa G: Abnormal expression of sphingomyelin acylase in atopic dermatitis: An
etiologic factor for ceramide deficiency? J Invest Dermatol 106: 1242-1249, 1996.
19. Nishijima T, Tokura Y, Imokawa G, Seo N, Furukawa F, Takigawa M: Alteredpermeability and disordered cutaneous immunoregulatory function in mice withacute barrier disruption. J Invest Dermatol 109: 175-182, 1997.
20. Umeda Y, Mizutani H, Imokawa G, Shimizu M: Topical ceramide corrected epidermal cell
hyperproliferation and stratum corneum dysmaturation in atopic eczema. New Trends
in Allergy 4: 237-239, 1997.
21. Kondo H, Ichikawa Y, Imokawa G: Percutaneous sensitization with mite antigens elicits
Th2-dominant cytokine response in a cutaneous barrier-disrupted model.

Eur J

Immunology 28: 769-779, 1998.
22. Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G,
Dohmae N, Takio K, Hattori M, Matsuo N: Purification, cDNA cloning, and expressionof UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.

J BiolChem 273: 13570-13577, 1998.
23. Imokawa G, Takagi Y, Higuichi K, Kondo H, Yada Y: Sphingosylphosphorylcholine is apotentinducerofintercellularadhesionmolecule-1

keratinocytes. J Invest Dermatol112: 91-96, 1999.

expression

in

human

24. Takagi Y, Kriehuber E, Imokawa G, Elias PM, Holleran WM: beta-glucocerebrosidase
activity in mammalian stratum corneum. J Lipid Res 40: 861-869, 1999.
25. Nishijima T, Tokura Y, Imokawa G, Takigawa M: Photohapten TCSA painting plus UVA
irradiation of murine skin augments the expression of MHC class II molecules and CD86
on Langerhans cells. J Dermatol Sci 19: 202-207, 1999.
26. Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G: High-expression of
sphingomyelin deacylase is an important determinant of ceramide deficiency
leading to barrier disruption in atopic dermatitis. J Invest Dermatol 115(3): 406-413, 2000.
27. Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G.: The skin of atopic dermatitis
patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, whichcleaves the N-acyl linkage of sphingomyelin and glucosylceramide. Biochem J 350: 747756, 2000.
28. Higuchi K, Kawshima M, Takagi Y, Kondo H, Yada Y, Ichikawa Y, Imokawa G.:
Sphingosylphosphorylcholine is an activator of transglutaminase activity in humankeratinocytes. J Lipid Res 42(10): 1562-1570, 2001.
29. Sogabe Y, Akimoto S, Abe M, Ishikawa O, Takagi Y, Imokawa G. Functions of the stratum
corneum in systemic sclerosis as distinct from hypertrophic scar and keloid functions. J
Dermatol Sci 29(1):49-53, 2002
30. Arikawa J, Ishibashi M, Kawashima M, Takagi Y, Ichikawa Y, Imokawa G: Decreased levelsof sphingosine, a natural anti-microbial agent, may be associated with vulnerability of thestratum corneum from patients with atopic dermatitis to colonization by staphylococcus
aureus. J Invest. Dermatol 119(2):433-439, 2002.
31. Hata M, Tokura Y, Takigawa M, Sato M, Shioya Y, Fujikura Y, Imokawa G: Assessmentof epidermal barrier function by photoacoustic spectrometry in relation to its importancein the pathogenesis of atopic dermatitis. Lab Invest 82: 1451-1461, 2002.
32. Okamoto R, Arikawa J, Ishibashi M, Kawashima M, Takagi Y, Imokawa G:
Sphingosylphosphorylcholine levels are significantly increased in the stratum
corneum of patients with atopic dermatitis: Physiological and functional relevance ofsphingomyelin deacylase to the ceramide deficiency. J Lipid Res 44: 93-102, 2003.
33. Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Oguchi K, Imokawa G:
The abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase andthe accumulation of its enzymatic reaction product, glucosylsphingosine in the skin ofpatients with atopic dermatitis. Lab Invest

88(3): 397-408, 2003.

34. Higuchi K, Kawashima M, Ichikawa Y, Imokawa G: Sphingocylphosphorylcholine is amelanogenic stimulator for human melanocytes. Pigment Cell Res 16: 670-678, 2003.
35. Takagi Y, Nakagawa H, Matsuo N, Nomura T, Takizawa M, Imokawa G: Biosynthesis ofacylceramide in murine epidermis: Characterization by inhibition of glucosylation anddeglucosylation, and by substrate specificity. J Invest Dermatol 122(3):722-729, 2004.
36. Takagi Y, Nakagawa H, Kondo H, Takema Y, Imokawa G: Decreased levels of covalently
bound ceramide are associated with UVB-induced perturbation of the skin barrier. J
Invest Dermatol, 123(6): 1102-1109, 2004.
37. Takagi Y, Nakagawa H, Higuchi K, Imokawa G: Characterization of surfactant-induced
skin damage through barrier recovery induced by pseudoacylceramide. Dermatology
211(2): 128-134, 2005.
38. Masukawa Y, Narita H, Imokawa G: Characterization of the Lipid Composition at theProximal Root Regions of Human Hair. J Cosmet Sci 56: 1-16, 2005.
39. Masukawa Yoshiori, Hiromi Shimogaki, Kenji Manago, Genji Imokawa: A novel method
for Visualizing hair lipids at the cell membrane complex: Argon sputter etching/scanningelectron microscopy. J Cosmet Sci, 56, 297-309, 2005.
40. Takigawa H, Nakagawa H, Kuzukawa M, Mori H, Imokawa G: Deficient production ofhesadecenoic acid in the skin is associated in part with the vulnerability of atopic
dermatitis patients to colonization by Staphylococcus aureus. Dermatology 211(3):2408, 2005.
41. Takagi Y, Nakagawa H, Yaginuma T, Takema Y, Imokawa G: An accumulation of
glucosylceramide in the stratum corneum due to attenuated activity of betaglucocerebrosidase is associated with the early phase of UVB-induced alteration in
cutaneous barrier function. Arch Dermatol Res 297(1):18-25, 2005.
42. Masukawa Y, Tsujimura H, Imokawa G: A systematic method for the sensitive and specificdetermination of hair lipids in combination with chromatography. J Chromatogr B Analyt
Technol Biomed Life Sci. 823(2): 131-142, 2005.
43. Matsuki H, Kiyokane K, Matsuki T, Sato S, Imokawa G. Re-characterization of the nonlesional dry skin in atopic dermatitits through disrupted barrier function. Exog Dermatol
3: 282-292, 2004 (2006)
44. Matsuki H, Kiyokane K, Matsuki T, Sato S, Imokawa G: Re-evaluation of the importanceof barrier dysfunction in the non-lesional dry skin of atopic dermatitis through the use of
two barrier creams. Exog Dermatol 3: 293-302, 2004 (2006)
45. Masukawa Y, Tanamachi H, Tsujimura H, Mamada A, Imokawa G: Characterization ofHair Lipid Images by Argon Sputter Etching-Scanning Electron Microscopy.
Lipid 41: 197-205, 2006.
46. Masukawa Y, Tsujimura H, Tanamachi H, Narita H, Imokawa G: Damage to Human Hair
Caused by Repeated Bleaching Combined with 138. Daily Weathering during Life
Activities. Exog Dermatol 3: 273-281, 2006(2004)

47. Asano S, Ichikawa Y, Kumagai T, Kawashima M, Imokawa G: Microanalysis of an antimicrobial peptide, -defensin-2, in the stratum corneum from atopic dermatitis patients.
Brit J Dermatol 159(1): 97-104, 2008.
48. Mori T, Ishida K, Mukumoto S, Yamada Y, Imokawa G, Kabashima K, Kobayashi M,
Bito T, Nakamura M, Ogasawara K, Tokura Y: Comparison of skin barrier
function and sensory nerve electric current perception threshold between IgE-highextrinsic and IgE-normal intrinsic types of atopic dermatitis. Br J Dermatol.
162(1):83-90, 2010.
49.

Yoshida N, Sawada E, Imokawa G: A reconstructed human epidermal keratinization
culture model to characterize ceramide metabolism in the stratum corneum. Arch
Dermatol Res 304(7):563-577, 2012.

50. Shuko Terazawa, Hiroaki Nakajima, Shingo Mori, Takao Niwano, Genji Imokawa:
Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 andinterleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS
depletion-independent

manner.

Exp

Dermatol.

2012;

21

Suppl

1:11-17.

DOI:10.1111/j.1600-0625.2012.01496.x
51. Sawada E, Yoshida N, Sugiura A, Imokawa G: Th1 cytokines accentuate but Th2 cytokines
attenuate ceramide production in the stratum corneum of human epidermal equivalents:
An implication for the disrupted barrier mechanism in atopic dermatitis. J Dermatol Sci
68(1):25-35, 2012.
52. Sugiura A, Nomura T, Mizuno A, Imokawa G: Reevaluation of the non-lesional dry skinin atopic dermatitis by acute barrier disruption: An abnormal permeability barrier
homeostasis with defective processing to generate ceramide. Arch Dermatol Res 306(5):427-440, 2014.
53. Terazawa S, Mori S, Nakajima H, Yasuda M, Imokawa G.: The UVB-stimulated
expression of transglutaminase 1 is mediated predominantly via the NFκB
signaling pathway: New evidence of its significant attenuation through the specificinterruption of the p38/MSK1/NFκBp65 Ser276 axis. PLoS One. 2015 Aug
25;10(8): e0136311. doi: 10.1371/journal.pone.0136311.
54. Hiroshi Nojiri, Koichi Ishida, Xueqiu Yao, Wei Liu, Genji Imokawa: Amelioration of lactic
acid

sensations

insensitive

skin

by

stimulatingthebarrierfunctionand

improving the ceramide profile. Archive of Dermatological Research 2018; 310(6): 495504. May 4. Doi: 10.1007/s00403-018—1833-9.
55. Shogo Takeda, Hiroshi Shimoda, Toru Takarada, Genji Imokawa: Strawberry seed extractand its major component, tiliroside, promote ceramide synthesis in the stratum corneumof human epidermal equivalents. PLoS One. 2018 Oct 9;13(10):e0205061. doi:10.1371/journal.pone.0205061. eCollection 2018.
56. Koichi Ishida, Akihiko Takahashi, Kotatsu Bito, Zoe Draelos, Genji Imokawa: Treatment
with Synthetic Pseudo-Ceramide Improves Atopic Skin Switching the Ceramide Profile toa Healthy Skin Phenotype. J Invest Dermatol. 2020 Sep;140(9):1762-1770.e8. doi:
10.1016/j.jid.2020.01.014.
57. Yasuhiro Teranishi, Hiroshi Kuwahara, Masaru Ueda, Tadashi Takemura, Masanori
Kusumoto, Keiji Nakamura, Jun Sakai, Toru Kimura, Yasuji Furutani, Makoto
Kawashima, Genji Imokawa, Mari Nogami-Itoh: Sphingomyelin deacylase, the enzyme
involved in the pathogenesis of atopic dermatitis, is identical to the β-subunit of acidceramidase. International Journal of Molecular Science Int. J. Mol. Sci. 2020, 21, 8789;
doi:10.3390/ijms21228789
58. Shogo Takeda, Shuko Terazawa, Hiroshi Shimoda, Genji Imokawa: β-Sitosterol 3-O-Dglucoside increases ceramide levels in the stratum corneum via the up-regulated
expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed
human epidermal keratinization model. PLoS One. 2021 Mar 8;16(3):e0248150. doi:
10.1371/journal.pone.0248150. eCollection 2021.
59. Mariko Takada, Yuko Ishikawa, Kayoko Numano, Shinichi Hirano and Genji Imokawa: A
Nano-Emulsion Containing Ceramide-like Lipo-Amino Acid Cholesteryl Derivatives
Improves Skin Symptoms in Patients with Atopic Dermatitis by Ameliorating the WaterHolding Function. Int. J. Mol. Sci. 2022, 23, 13362; doi: 10.3390/ijms232113362
60. Tami Igarashi, Hiroki Yanagi, Masayuki Yagi, Masamitsu Ichihashi and Genji Imokawa:
Horse-derived ceramide accentuates glucosylceramide synthase and ceramide synthase 3
by activating PPARβ/δ and/or PPARγ to stimulate ceramide synthesis. Biomedicines
2023, 11, 548. https://doi.org/10.3390/biomedicines11020548
61. Miho Sashikawa-Kimura, Mariko Takada, Md Razib Hossain, Hidetoshi Tsuda, Xiaonan
Xie, Mayumi Komine, Mamitaro Ohtsuki and Genji Imokawa : Overexpression of the βSubunit of Acid Ceramidase in the Epidermis of Mice Provokes Atopic Dermatitis-like
Skin Symptoms. Int. J. Mol. Sci. 2024, 25, 8737; doi: 10.3390/ijms25168737

3-2. 日本語原著論文（18 報）
1. 赤碕秀一, 峰松義博, 吉塚直伸, 芋川玄爾:
質の役割.

角層水分保持機能における角質細胞間 脂日本皮膚科学会誌 98: 40-51, 1988

2. 河合道雄,芋川玄爾, 岡本暉公彦: 皮膚つっぱり感と界面活性剤.
430- 436, 1989

皮膚科診療

11:

3. 河合道雄,

芋川玄爾, 溝口昌子: 角質細胞診断法と角層ターンオーパー測定法による顔面皮膚性状解析. 日本皮膚科学会誌

99: 999- 1006, 1989

4. 河合道雄, 小山内宰, 芋川玄爾: 角質細胞の形態. 日本香粧品科学会誌 15:231-237,1991
5. 吉村政哲, 城倉洋二、 花沢英行、 野崎利雄、 奥田峰広, 芋川玄爾: アミノ酸誘導体型
界面活性剤ラウロイルベーターアラニンの皮膚に及ぼす影響. 日本
化粧品技術者会誌 27: 249-254, 1993
6. 城 倉 洋 二, 石 川 伸 二, 山 崎 誠 二, 芋 川 玄 爾: 固体 高分 解 能 13C-NMR による角層 柔 軟化機 構 の解 明†J. Soc. Cosmet. Chem. Jpn. 27 (3) 348-354 (1993)
7 .城倉博子, 東清史、鈴木敏幸, 芋川玄爾: 無機粉体の紫外線防御機構.
者会誌

日本化粧品技術

28: 254-261, 1994

8. 鈴木淳子、萬秀憲, 芋川玄爾、高島厳: 分岐脂肪酸コレステリルエステル配合浴用剤の保湿効果.

西日本皮膚科会誌、 56: 494-498, 1994

9. 福田行男, 神谷哲朗, 刀禰寛, 安藤正知, 萬秀憲, 土屋秀一、 西澤義則、北山隆, 芋川玄爾: ラット摘出大動脈に対する 3-octylphthalide(NY-008)の血管弛緩作用誌

日薬理105: 381-388, 1995

10.近藤知子, 奥田峰広, 芋川玄爾: 食器用洗浄剤の皮膚への影響と皮膚 刺激緩和作用について.

日本皮膚科学会誌 105: 1217-1225, 1995

11.樋口和彦、村田恭子、川島真、芋川玄爾: 血液透析患者の乾燥皮膚に関してー角質細胞
間脂質、セラミド量の解析ー. 臨床透析 15: 129-132, 1999
12. 水谷 仁、高橋眞智子、清水正之、刈屋 完、佐藤広隆、芋川玄爾。アトピー性皮膚炎患者に対する合成疑似セラミド含有クリームの有用性の検討。西日本皮膚科会誌

６３巻４号 457-461, 2001
13. 山中正義、石川 治、高橋昭彦、佐藤広隆、芋川玄爾. アトピー性皮膚炎患者に対する「キュレル R 薬用クリーム」の有用性の検討。皮膚 43 卷 4,5 号 341-347, 2001
14. 宍戸悦子、塚原和枝、藤村努、森脇繁、武馬吉則、川島眞、芋川玄爾、アミジノ-L-プ
ロリンの目尻の小じわに対する改善効果。 皮膚の科学 第１巻・第５号

３５５－

３６２、２００２
15. 秦 まき、戸倉新樹、瀧川雅浩、田村辰仙、芋川玄爾。アトピー性皮膚炎に対する合成疑似セラミド含有クリームの有用性の検討――尿素含有クリームとの比較―西日本
皮膚科 第６４巻第５号 ６０６－６１１、２００２
16. 赤崎秀一、中川秀己、風間治仁、河合通雄、武馬吉則、芋川玄爾：新しい 3 次元直接形状評価システムを用いたシワを中心とする皮膚表面形態の評価。自治医大医学部紀要 25：17－28、２００２
17. 高島 巌、長谷部恵子、奥田峰広、芋川玄爾。アトピー性皮膚炎および乾燥性湿疹患者に対する均一分散合成擬似セラミド配合身体洗浄剤の有用性の検討。西日本皮膚科

第６４巻第５号 ６１２－６２０、２００２18. 船坂陽子、尾藤利憲、山本麻由、錦織千佳子、市橋正光、中村正、石田耕一、佐藤広隆、芋川玄爾。
「キュレルＵＶミルク」および「キュレルＵＶクリーム」の 低バリア機
能皮膚に対する使用経験。皮膚の科学 第３巻、第１号 ６２－７２、２００４

3-3. 乾燥アトピー性皮膚炎関連英語総説論文 (8 報)
1. Imokawa G., Takeuchi T: Surfactants and skin roughness. Cosmetics & Toiletries 91: 3246,1976.
2. Imokawa G.: Comparative study on the mechanisms of irritation by sulfate and phosphate
type of anionic surfactants. J Soc. Cosmet Chem 31: 45-66, 1980
3. Imokawa G., Takema Y.: Fine wrinkle formation: etiology and prevention. Cosmetic &Toiletaries 108: 65-77, 1993.
4. Imokawa G. Lipid abnormalities in atopic dermatitis. J Am Acad Dermatol 45: S29-32, 2001
5. Imokawa G: Surfactant-induced depletion of ceramides and other intercellular lipids:
Implication for the mechanism leading to dehydration of the stratum corneum. Exog
Dermatol 2006(2004); 3: 81-98.
6. Imokawa G: A Possible Mechanism Underlying the Ceramide Deficiency in Atopic
Dermatitis: Expression of a Deacylase Enzyme that Cleaves the N-Acyl Linkage of
Sphingomyelin and Glucosylceramide. J Dermatol Sci 55(1):1-9. 2009
7. Imokawa G, Ishida K.: Role of Ceramide in the Barrier Function of the Stratum Corneum,
Implications for the Pathogenesis of Atopic Dermatitis. J Clin Exp Dermatol Res 2014; 5:
206. doi: 10.4172/2155-9554.1000206
8. Genji Imokawa: Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin
Deacylase, the Enzyme Involved in its Ceramide Deficiency, Plays a Pivotal Role. Int J Mol
Sci. 2021 Feb 5;22(4):1613. https://doi.org/10.3390/ijms22041613

3-4. 乾燥アトピー性皮膚炎関連日本語総説論文（46 報）
1. 芋川玄爾: 表皮角層変化の評価法.

香粧品科学会誌 8:92- 108, 1984.

2. 芋川玄爾, 吉塚直伸: 皮脂膜と肌特性. Fragrance J. 12: 84-89, 1984
3. 芋川玄爾: モノアルキルリン酸（MAP）の機能と作用. Fragrance J. 12: 21-27, 1984
4. 芋川玄爾: 洗顔と洗顔料についてー皮膚の生理と安全性ー. Fragrance J. 74: 38-47,1985.
5. 黒崎富裕, 芋川玄爾, 石田篤郎: 低刺激性アニオン界面活性剤としてのモノアルキルフォスフェート(MAP)の皮膚刺激性、生化学特性,工業化法. 油化学 36: 629- 637, 1987.

6. 芋川玄爾: 角層保湿機能と細胞間脂質. Fragrance J. 15: 35-41, 1987
7. 芋川玄爾: 角質細胞間脂質の機能とその応用. Fragrance J. 4: 26- 34, 1990.
8. 芋川玄爾:

角層水分保持機構における角質細胞脂質の機能. 日皮協ジャーナル

13:

17-23, 1990.
9. 芋川玄爾: 角層脂質の性状、機能とその測定. 臨床皮膚科 44: 583-588, 1990.
10. 芋川玄爾: 角質細胞間脂質の機能とその応用. 皮膚と美容 23: 3806-3818, 1991.
11. 芋川玄爾: 角質細胞間脂質. 香粧品科学会誌 15: 250-253, 1991.
12. 河合道雄, 芋川玄爾:

脂性肌の再評価と今後の課題. Fragrance J 5: 29-39, 1991.

13. 芋川玄爾, 武馬吉則: しわを科学する、表皮（脂質、水.） 香粧品科学会誌 16:153-155,
1992
14. 芋川玄爾, 武馬吉則: 表皮、特に角質層が関与する小じわの発生要因とその予防.
Fragrance J. 11: 29-42, 1992.
15. 芋川玄爾: 角質細胞間脂質の機能と乾燥性皮膚疾患. 皮膚科の臨床35: 1147-1161,

1993—(7)16. 芋川玄爾: 角層水分保持作用と DRY SKIN の発生と治療薬. Dermatology Today 1: 811, 1994.
17. 芋川玄爾: アトピーおよび老人性乾燥皮膚に関与する酵素. 酵素工学 33: 5-10, 1995.
18. 芋川玄爾: 皮膚角質細胞間脂質の構造と機能. 油化学 44: 51-66, 1995.
19. 芋川玄爾: しわとこじわ. 香粧品科学会誌 20: 284-288, 1996.
20. 芋川玄爾: ドライスキンと角質細胞間脂質. やさいし眼科学 13: 111-119, 1996.
21. 芋川玄爾: アトピー性皮膚炎とスフィンゴ脂質代謝異常.

The Lipid

7: 428-432,

1996.
22. 芋川玄爾, 川島真:

アトピー性皮膚炎と角質細胞間脂質.

Tokyo Tanabe Quarterly

42: 41-52, 1997.
23. 芋川玄爾: アトピー性皮膚炎、どうしてかさかさするの. 日本小児皮膚科 16: 87-99,
1997.
24. 芋川玄爾: 皮膚科領域で使用される保湿剤. 日本臨床皮膚科医学会雑誌 56: 87-96,
1998.
25．芋川玄爾: Sphingomyelin deacylase とアトピー性皮膚炎, 皮膚疾患と酵素 up date,Monthly Book: Derma デルマ, 全日本病院出版会 1999:15-23
26. 芋川玄爾: 皮膚角層の保湿機能と角層成分の役割. Fragrance J. No 17: 27-39, 2000.
27. 石橋睦子、芋川玄爾、川島眞：バリア病としてのアトピー性皮膚炎。日本医師会雑誌
126(1): 33-36, 2001
28. 芋川玄爾：皮膚のバリア機能と皮膚での免疫応答。臨床免疫 35: No.6, 746-753,2001
29．芋川玄爾：洗浄剤と皮膚〔洗浄剤の皮膚に与える影響〕、日皮協ジャーナル 3:43-48、2003

30．芋川玄爾：皮膚の乾燥メカニズムと洗浄・スキンケアーのあり方。皮膚と美容 36：22－40、２００４
31. 石田耕一、芋川玄爾；手に接触する洗浄剤について知っておくべきこと. Monthly Book
Derma デルマ（MB Derma）、全日本病院出版会 107: 45-53, 2005:
32. 芋川玄爾：アトピー性皮膚炎とバリア機能異常。治療学、ライフサイエンス出版社
2005：39：２２－３１
33．川島眞、石田耕一、河合通雄、芋川玄爾、高島和典：アトピー性皮膚炎患者でのメイク
アップ化粧品の効用。日本香粧品学会誌 29：139－142、２００５
34. 芋川玄爾：皮膚成分の刺激による変動と測定法

角層バリアー機能 Cosmetic Stage

１巻１号 ４０-５４、２００６
35. 芋川玄爾：皮膚への種々環境刺激による変動と測定法

角層水分量 Cosmetic Stage 1

巻２号 ４７-６１、２００６
36. 芋川玄爾：

バリア機能のメカニズムと香粧品とのかかわり方。日本香粧品科学会誌

22: 312-318, 2007.
37. 芋川玄爾：機能性化粧品の展望。Monthly Book Derma デルマ（MB Derma）、全日本病院出版会 2007: 132: 175-189
38. 石田耕一、芋川玄爾：子供の健常な皮膚を維持するためのスキンケアの概念。チャイルドヘルス 10 (5) 308-315, 2007
39. 芋川玄爾： アトピー性皮膚炎のバリア機能異常。 アレルギーの臨床２８（２）１７－２７（１０５－１１５）、２００８
40. 芋川玄爾： アトピー性皮膚炎の病態―バリア異常の立場からー

日本皮膚科学会誌

第１１８巻 第１３号 ２６６０－２６６４、 ２００８
41. 芋川玄爾：アトピー性皮膚炎「何故スキンケアは必要か」日本小児皮膚科学会誌 第２７巻 第 2 号 ４６－５３、 ２００８
42. 芋川玄爾：

アトピー性皮膚炎の病態―バリア異常の立場から。

Biotherapy

２4１119-218 ２010
43. 芋川玄爾： アトピー性皮膚炎の病態と治療 アトピー性皮膚炎における皮膚バリア機
能異常。 MB Derma １７５ ２１－３２、２０１１
44. 芋川玄爾：ビオレを誕生させた皮膚科学の権威。Cosme Tech Japan 1(6), 2011
45. 芋川玄爾： 水はどこまでわかっているのか４

ぷるるん肌を支える皮膚角層の水分。

化学と工業 ６４－７：５３８－５３９、２０１１
46. 芋川玄爾：
1(6), 2011

ぷるるん

肌を作る

セラミドと水の関係を発見

Cosme Tech Japan

3-5. 乾燥アトピー性皮膚炎関連英語著書（7 報）
1. Kawai M., Yoshizawa N., Imokawa G., Okamoto K., Toda K.:

Acrolein vapor fixationelectron microscopy of the horny layer. ed. by Seiji, M and Bernstein, I.A. In: Normaland Abnormal Epidermal Differentiation, Univeristy of Tokyo Press, 1983: 207-214
2. Imokawa G.: Water and the Stratum Corneum (Volume 1). Chapter 3. VITRO AND IN
VIVOMODELS.

ed.

By

Elsner,P,

Berardesca,

E

and

Maibach,H.I.

BIOENGINEERING OF SKIN, CRC Press, 1994: 23-47
3. Imokawa G.:

Chapter Surfactant Mildness ed. by Rhein and Luger, Surfactants in

Cosmetic, Marcel Dekker, Inc. 1995：123-145
4. Imokawa G.: Skin Moisturizers: Development and Clinical Use Ceramides. ed. By M.
Loden, Dry Skin and Moisturizers, CRC Press, 1999: 269-299
5. Imokawa G: Ceramides as natural moisturizing factors and their efficacy in dry skin. ed.
By Leyden JJ and Rawlings AV, Skin Moisturization, Marcel Dekker INC.,
2001 pp267-302
6. Imokawa G.: Deranged antimicrobial barrier in atopic dermatitis: Role of sphingosine,
hexadecenoic acid and beta defensin-2. Innate Immune System of Skin and Oral Mucosa:
Properties and Impact in Pharmaceutics, Cosmetics and Personal Care Products, First
Edition. Nava Dayan and Phil Wertz.

2011; pp307-323, John Wiley & Sons, Inc.

Published 2011 by John Wiley & Sons, Inc.
7. Imokawa, G. Role of stratum corneum ceramide in water and barrier functions: Implication
to pathogenesis of atopic dermatitis. In Cutting Edge on Molecular Mechanisms of Skin
Ageing and Its Rational Anti-Aging Treatments and Pathogenesis of Atopic Dermatitis;
Imokawa, G., Ed.; Book Publisher International: London, UK, 2021; Chapter 4; pp. 146–
148, 172–173. https://doi.org/10.9734/bpi/mono/978-93-90516-55-1

3-6. 乾燥アトピー性皮膚炎関連日本語著書（18 報）
1. 芋川玄爾: 角質細胞間脂質. 現代皮膚科学大系, 中山書店, 1990: 43-53
2. 芋川玄爾, 溝口昌子:

皮膚と界面活性剤.

I 基礎編: バイオサーファクタント. サイ

エンスフォーラム, 1990: 287-302
3. 芋川玄爾: 第３章

界面活性剤との相互作用と最新技術, シーエムシー社

１.２. 皮膚. 機能性界面活性剤の開発

1994: 120-147

4. 芋川玄爾: ドライスキンと保湿のメカニズム、乳液、クリーム、保湿剤、化粧品．臨床医のためのスキンケアー入門、 先端医学社, 1997：114-138
5. 芋川玄爾：皮膚機能性界面活性剤の開発技術.

発行者：島健太郎, 発行所：株式会

社 シーエムシー 1998 pp 120－147
6. 芋川玄爾:セラミド. 皮膚疾患, KEY WORD 1999-2000 先端医学社, 1999: 86-87
7. 芋川玄爾: スキンケア剤ー保湿剤（含むハンドケア）. 美容皮膚科 プラクテイス 南山堂, 1999: 176-190
8. 芋川玄爾：表皮角層水分保持機能. 水と生命‐熱力学から生理学へー 担当編集委員:永山国昭

編者:日本生物物理学会/シリーズ・ニューバイオフィジックス刊行委員会、発行者：南條光章、発行所：共立出版株式会社、２０００: pp 152-164
9. 芋川玄爾: 角質細胞間脂質. 機能性化粧品の開発

監修：高橋雅夫, 発行者：島 健太郎, 発行所：株式会社 シーエムシー ２０００ pp ２３５－２５２
10. 芋川玄爾: セラミド. 最新皮膚科学大系, 第７巻
０１:｢角化異常性疾患｣中山書店, ２０

ｐ ３４－４２

11. 芋川玄爾： ドライスキン 乾燥するカラダ 坪田一男 編著 ５３－６５、２００２
12. 芋川玄爾: セラミドとはなにか？ Topics in Atopy. vol 2 no. 3, 49-61, 2003
13．芋川玄爾：保湿バリアのメカニズムと全般技術背景。バイオテクノロジーシリーズ機能性化粧品素材開発のための実験法―in vitro/細胞/組織培養 ２００７

監修 芋川玄爾シーエムシー出版 pp 3-11.
14．芋川玄爾：単著本 ヒト皮膚測定評価試験マニュアル、保湿剤。２００７出版社：技術情報協会
15．芋川玄爾：単著本 ヒト皮膚測定評価試験マニュアル、バリアー補強材。２００７出版
社：技術情報協会
16.芋川玄爾：ドライスキンと保湿：皮膚科診療最前線シリーズ スキンケア最前線 ２

００８ 編集 宮地良樹 発行所 株式会社メデイカルレビュー社 pp１０８－１１９
17. 芋川玄爾：皮膚とセラミド：セラミド―基礎と応用―ここまできたセラミド研究最前線
2011 編集 セラミド研究会

発行所：株式会社 食品化学新聞社 pp 63-73

18. 芋川玄爾：セラミドの皮膚への応用：セラミド―基礎と応用―ここまできたセラミド研
究最前線
128-1392011

編集 セラミド研究会

発行所：株式会社

食品化学 新聞社

pp