FY2019 Report of Activities

Radiation Effect Research Foundation

FY2019 Report of Activities
I. Report of Major Activities
Epidemiologic data on mortality and cancer incidence from the A-bomb survivors (the Life
Span Study [LSS], the in utero study) and their children (the F1 generation studies) have long
been a primary basis for national and international estimates of the risks of cancer and otherdiseases from exposure to ionizing radiation. The unique importance of the LSS study stems
from the combination of its large size, wide range of exposure levels, inclusion of all ages at
exposure, and long, high-quality follow-up of mortality and cancer incidence. However, the
LSS is only one facet of RERF’s research activities. Clinical examinations and the collectionof biosamples in the Adult Health Study (AHS, a subsample of the LSS) and the clinical,
epidemiological and genetic studies of the children of A-bomb survivors provide moredetailed information on health conditions of interest, including radiation-related non-cancer
conditions, and the pathogenesis of those conditions in relation to radiation exposure, as wellas the study of heritable mutations. Our basic science groups, in collaboration with the clinicalstudies and epidemiology departments, utilize the biosamples to further address the nature andextent of genetic (both heritable and somatic) effects, and molecular changes associated withhealth risks. These three components within the RERF research program provide an
integrative approach into epidemiological, clinical, biological, and mechanistic aspects ofhuman radiation risk. Such integrated opportunities are unique to RERF and demand the best
possible science be conducted for the benefit of the survivors and the radiation researchcommunity. As we move forward, the primary focus of RERF studies will be on suchintegrated research programs through their development within the cancer, genetic and noncancer research clusters. An additional and essential component of our research program
development is the expansion of collaborations with institutions outside of RERF both inJapan and internationally.
1. Research Projects Examining A-bomb Survivors Health1) Radiation and Cancer:• We evaluated the modifying effects of chronic gastritis on radiation risk of noncardia
gastric cancer by histological types by reanalyzing data from a nested case-control study
conducted within AHS participants. The results indicated that radiation exposure isassociated with increased risk of diffuse-type noncardia gastric cancer without chronic
atrophic gastritis, and this association exists despite adjustment for H. Pylori infection andsmoking habit.
• Periodic reporting on the radiation risks of cancer incidence is an important task for the
epidemiology department. Papers on all solid cancer, lung cancer, breast cancer, and uterus
cancer were published in 2018 while papers on colorectal cancer (Sugiyama H, et al. Int J
Cancer 2019;146:635-645), liver cancer (Sadakane A, et al. Radiat Res 2019;192:299310), and upper digestive cancer (Sakata R, et al. Radiat Res 2019; 192:331-44) were
published in 2019. A paper on central nervous system tumors (Brenner A, et al.) was justaccepted by Eur J Epidemiol and a paper on prostate cancer (Mabuchi K, et al.) is being
reviewed by Radiat Res. Papers on ovarian cancer (Utada M, et al.) and comparison ofcancer incidence and mortality (Brenner A, et al.) are being drafted. The series of recent
papers focused on the shape of the dose-response curves, low-dose risk and risks among
those young at exposure, while adjusting for relevant life-style factors. A paper

1investigating the origin of curvature in the male dose-response for solid cancer incidence
was published by Dr. Cologne of Dept. Statistics.
• A paper evaluating the influence of medical radiation exposure on the risk estimates ofatomic bomb radiation in the LSS was published (Sadakane A, et al. Radiat Res
2019;191:507-17). There was no substantial impact of diagnostic radiation exposure on
radiation risks from atomic bomb exposure.
2) Radiation and Non-Cancer Effects:• Cataract: Ophthalmologic examinations for our cataract study were initiated in Hiroshima
and Nagasaki in collaboration with ophthalmologists in Hiroshima and Nagasaki
Universities in April 2016. Supervision for this study is made by a cataract specialist in
Kanazawa Medical University. Ophthalmologic examinations among 891 AHS subjects
who were <15 years of age at the time of bombings (except in- utero exposed subjects)
were finished in March 2019 in Hiroshima and Nagasaki. Scoring of cataract severity using
photographed images was also completed by an ophthalmologist and statistical analysis
was started in collaboration with the Statistics Department. The same ophthalmologicalexaminations among in-utero exposed subjects were initiated in April 2018 and wascompleted by March 2020.
3) Immunologic Effects of Radiation:• Clonal hematopoiesis (CH), associated with radiation exposure and increased risks ofinflammatory diseases, has not been evaluated in animal model studies. To develop
strategies for assessments of CH potentially linking to radiation-associated noncancer
diseases, specifically arteriosclerosis, we have proposed a research plan to establish one ormore mouse models that can test the hypothesis that CH in irradiated mice is involved in
pro-inflammatory phenotypes and can promote atherosclerosis formation. Mouse models
to be developed in this research may be useful for assessing the effects of a variety ofenvironmental factors on somatic mutagenesis and CH development. Preliminary
experiments conducted in FY2019 indicated 1) that it is difficult to identify CH with
viable mutant cells in the HPRT-dup-GFP model (Noda, PLos One 2015) since none of 42
irradiated mice had a large amount of mutant GFP-positive blood cells; 2) that longitudinal
analyses of hematologic indicators are feasible since RDW (Red cell Distribution Width)and monocyte counts, which are known to be associated with CH in human, increased insome of the 3-Gy irradiated mice; and 3) that using digital-droplet RT-PCR and flow
cytometry, CH-related pro-inflammatory phenotypes can be evaluated with expression
levels of inflammatory genes in BM-derived macrophages. Based on these results, we
decided to use whole-exome sequencing (WES) but not the HPRT-dup-GFP system for
CH identification. Currently, BM DNA samples from 8 irradiated and 4 control mice arebeing assessed for WES to identify CH with recurrent somatic mutations, which we expect
to investigate the feasibility of mouse BM WES for CH assessment. We have also plannedclonality assessment of monocytes accumulating in atherosclerotic plaques that are formedin LDLR-KO mice irradiated and fed with a high-fat diet, which would be able to test the
hypothesis that CH following radiation exposure promotes atherosclerosis formation
through clonal accumulation of pro-inflammatory monocyte into atherosclerotic lesions.
This proposal has been fully discussed and approved in the Noncancer Research Cluster.
(Kusunoki, Yoshida, Taga, Hamasaki, Satoh, Uchimura, Misumi and Noda, a new RP in
the Clonal Hematopoiesis Program Project).

2**2. Research Projects on the Health of A-bomb Survivors Children (F1)
• F1 cohort study (RPs 4-75, 18-61): Long-term studies of the F1 cohort provide aframework for studying germline effects of radiation exposure and contribute importantdata to the largest study of its kind. After a major paper on mortality risk assessment was
published in 2015, routine collection of case information is continuing. The individual
doses of F1 cohort members are being updated to DS02R1. As residential information isessential for ascertainment of cancer incidence through the national cancer registry system,
the information on participants in the F1 Offspring Clinical Study (FOCS) has started to be
used.
• Genetic Effects: The initial examination of the longitudinal F1 clinical cohort from 2002 to2006 (the first round examination) provided no evidence for an increased prevalence ofadult-onset multifactorial diseases due to parental radiation exposure, but the study
subjects were still quite young. Definitive human data can only be obtained if a highquality clinical study is continued until the subjects become elderly, when many
multifactorial diseases develop. The objective of this study is to elucidate the effects ofparental exposure to A-bomb radiation on the development of polygenic, multifactorialdiseases such as diabetes, hypertension, dyslipidemia, ischemic heart disease, and stroke,and subclinical conditions among the F1 offspring. Self-selection bias also tends to beminimized when prospective longitudinal data are obtained, because such data allow
estimates of disease incidence. Thus far we have:
Almost completed the third round examination of the F1 offspring clinical study (FOCS)
that was initiated in November 2014 on a four-year cycle. 9,750 subjects participated andparticipation rate during this cycle was 74.4%. Continued conducting the third roundexamination and started the fourth round in November 2018.
Initiated efforts to develop an integrated program project in collaboration with
Departments of Epidemiology, Molecular Biosciences, and Statistics. Organized as anumbrella program project for investigation of genetic effects of atomic bomb radiation to
the Genetic Research Cluster.
• A study characterizing radiation-induced small-size deletions in F1 mice born to exposed
spermatogonia or mature oocytes was conducted. This study aimed to clarify
characteristics of radiation-induced indels identified in F1 mice born to exposed
spermatogonia or mature oocytes. We also examined further details of neighboring
sequences of de novo mutations. Also, we examined the number of de novo mutations of
unexposed parental alleles to estimate the aging effect on de novo induction of SNVs. We
found two types of remarkable characteristics of small deletions in exposed group; one issmall deletions (mainly 1~12 nucleotides) in non-repeat sequences, many of which showed
microhomology at the breakpoint junction, and the other is single-nucleotide deletions inmononucleotide repeat sequences. These data suggest that deletions having the above
mentioned features as well as multisite mutations could be typical signatures of mutations
induced by parental irradiation in mammals.
3. Research to Elucidate Individual Doses and Effects from the A-bomb• The Department of Statistics coordinated and collaborated in the work of the binational
working group that was tasked with developing an improved approach to organ dosimetryby using existing, DS02-calculated shielded radiation fields with new “leakage” tables
calculated from new and improved computational phantoms. This work has resulted in a3

series of papers comparing new sets of phantoms, designated as “J45,” to DS86/02
phantoms, using idealized irradiation geometries, i.e., all neutrons and gamma-rays
arriving from the same direction, e.g., antero-posterior, or at random from all directions(isotropic). The first paper (Griffin, Paulbeck, Bolch 2019) evaluated the dosimetricdifferences from using an updated and age-expanded J45 phantom series. The second(Paulbeck, Griffin, Lee 2019) extended this work by examining the atomic bomb photon
and neutron field incident upon the adult pregnant female. The third paper, currently inreview (Sato, Funamoto, Paulbeck 2019) investigated the potential impact of introducing
not only the J45 series but also radiological physics methodological upgrades into thedosimetry system. A fourth paper, currently in development, (Paulbeck, Sato, Funamoto2020) expands upon the initial study (Paulbeck, Griffin, Lee 2019) by performing survivor
dose reconstructions with the J45 PF phantom series using DS02 specific particle fluencesin terms of particle type, energy, and direction at both cities and for five localizedshielding exposure scenarios.
• In order to investigate the effects of A-bomb radiation on humans, a cytogenetic biologicaldosimetry study was conducted for a subset of A-bomb survivors in the AHS cohort. A
total of 1,868 survivors (1,179 in Hiroshima and 689 in Nagasaki) were examined using
the 2-color-FISH method for detecting the frequency of stable translocations involving
chromosomes 1, 2, and 4. An overview of some of the results are as follows: (1) the overall
dose-response for translocation frequency was nonlinear, wherein the slope leveled off in
the higher dose range (above around 1.25 Gy); (2) a wide scatter of individualtranslocation frequencies against DS02R1 dose was observed in both cities, as seen in theprevious Giemsa staining study; (3) the Nagasaki factory workers had a significantly lower
dose-response than those exposed in Japanese houses; (4) the city difference was no longer
significant after excluding the Nagasaki factory workers; (5) observed dose responses werealso significantly lower among survivors whose shielding categories were outside but
shielded, in open without shielding, and in other house; (6) Such differences in dose
response among different shielding categories suggests a systematic, shielding-related bias
in physical dose estimates.
4. Projects to Release Research Results and to Collaborate with Other Scientific
Organizations
Crucial to the mission of RERF is the dissemination of results of our studies to survivors andtheir children and to the international community. Toward that end we interact with local
liaison councils representing the communities of Hiroshima and Nagasaki and provide
information via public lectures and other activities. These will be described later in anothersection of this report. With respect to the international community there are a number ofactivities. These include seminars, workshops, participation at international scientificconferences, and international publication of results. This year 7 seminars were held at RERF
presented by national and international visitors to RERF, and published more than 50
scientific papers.
Collaborative Research Projects
 Ongoing international collaborative research projects
In addition to the above activities the development of national and international
collaborations is essential to help disseminate results and to enhance RERF research
programs. A list of current collaborations is provided below:

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a. Partnership with the University of Washington
b. Partnership with Kurume Universityc. Collaborations with the US National Cancer Instituted. Collaborations with the University of Florida
e. Collaborations with Outside Investigators:
42 Japanese Institutions
10 North American Institutions
8 European Institutions
1 Asian, Oceanian Institution
5. Training Programs for Domestic and Overseas Specialists
1) An “Epidemiological Training course for Radiation Biologists” was held to deepen
biologists’ understanding of RERF’s epidemiological studies and to also promoteexchanges among researchers working for radiation-related organizations (August 19–20,
2019; 77 participants in total—39 from outside and 38 from RERF).
2) RERF accepted overseas research trainees, in support of the activities of suchorganizations as the Hiroshima International Council for Health Care of the Radiationexposed (HICARE), the Nagasaki Association for Hibakushas’ Medical Care (NASHIM),
the Japan International Cooperation Agency (JICA), and the Nagoya University Graduate
School of Medicine (125 trainees in total). A trainee, who was accepted by HICARE,
received lectures on research methods and the results of past studies and took part inexperiments and analyses to deepen her understanding of the health effects of radiation at
RERF for about four weeks.
3) RERF cooperated in the international training course jointly held by the International
Atomic Energy Agency (IAEA) and HICARE (February 17–21, 2020; 21 participants intotal), and provided lecturers and offered a venue for the training course on February 21,
2020.
4) RERF further reviewed future directions for its training activities, including an approachof publicly inviting overseas trainees in the International Exchange Research Program; inthis regard, we posted a public invitation and the guidelines for application on the RERF
website. In FY2019, RERF received seven applications and accepted two trainees.
6. Public Information Programs
1) RERF Open House events
In fiscal year 2019, RERF held its 25th Open House August 5–6 at the Hiroshima
Laboratory and its 23rd Open House August 8–9 in Nagasaki. The Open House event inHiroshima on August 5 featured the lecture titled “School Visit Program: What’s
Radiation?” On the next day, August 6, in celebration of the Open House event’s 25th
anniversary, a lecture was held titled “Radiation around Us and RERF’s Research.”
At the Nagasaki Laboratory on August 8, the Open House featured the special
presentation “Is radiation visible? Let’s watch radiation’s movement in an experimental
setting.” In Hiroshima, several science corners were established—“Liquid nitrogen: Whatis the world of -196°C like?” and “Extract DNA,” among others—at which science
experiments were conducted, with hands-on learning opportunities also provided. As
usual, a “Quiz stamp rally” was featured, in which children and young visitors moved
throughout the facilities to complete the quiz. In Nagasaki, several science corners were5

set up, including bone density testing, liquid nitrogen experiments, body fat measurement,
and more.
The two-day Open House events attracted 688 and 416 visitors in Hiroshima andNagasaki, respectively.
2) Enhanced RERF website• The comprehensive overhaul of the RERF public website was completed in June 2018.
During FY2019, the new homepage was regularly updated with revised information.
• Starting in the fall of 2018, when papers are published in scientific journals, new easyto-follow synopses of papers were posted on the public website.
• The total number of RERF website hits, or page views, between April 1, 2019, andMarch 31, 2020, was 394,723, with the daily average being around 1,079. The total
number of website visitors for the same period was 157,236, with the daily average
about 430.**These numbers are the result of a new system of assessment called Google Analytics, the use of which
was initiated in June 2018.

3) Public relations activities using social media• RERF continues to convey information through its Facebook page. Currently, the pagehas 838 followers.
• RERF launched both English and Japanese versions of Twitter. Both accounts together
currently have more than 420 followers in total.
4) Media gatherings
RERF held get-togethers with the media to improve and strengthen relations, given thatjob transfers in that work are regular occurrences, resulting in a high degree of turnover inreporters that cover RERF as part of their beat. In October 2019, RERF held in Hiroshimaa guidance session for younger journalists not familiar with RERF’s work (21 participantsfrom 10 media concerns). Furthermore, in response to requests from media concerns in
Hiroshima, RERF held a gathering with the local Chugoku Shimbun in October (eight
media members), another with the Kyodo Tsushin wire service in December (six media
members), and again, in January 2020, a New Year’s gathering with all media (18 media
members from 10 companies). From these efforts to improve communications, RERF
received five requests for interviews.
5) Public lectures
In cooperation with the Public Awareness Campaign working group, which is designed toconvey RERF’s activities, RERF enhanced its communication with the Hiroshima Peace
Memorial Museum by giving a presentation to about 200 peace museum volunteers andPeace Forum members. In cooperation with the Nagasaki Peace Promotion Association,
RERF provided a lecture at the Nagasaki Atomic Bomb Museum for about 70 people,
including peace volunteers and guides.
6) School Visit Program
In Hiroshima, the RERF School Visit Program, which is an attempt to teach radiation
health effects to school children using readily understandable language, was involved in
FY2019 in 21 lectures to 11 organizations, including junior high schools, groups visiting
the Open House event, peace volunteer groups, and other visitor groups.

67) Updating of public relations materials
Subscribing to RERF’s electronic subscriber list email magazine, initiated in April 2019,was made possible from our website. As of March 31, 2020, the email magazine
generated close to around 300 subscribers, with 11 email magazine issues sent out to thatpoint in time. Utilizing this new media format, RERF will continue sending RERF
research results and other related information to interested citizens.
In addition, the Annual Report had previously been discontinued in its hard-copy format,
with three years (FY2016–FY2018) of the new Report of Annual Activities posted
exclusively online.
8) Other public relations activities• As part of its public relations activities through the media, RERF held press
conferences at the time of important functions and newsworthy events, as well as at
publication of topical papers. RERF also responded to inquiries and requests forinterviews from many domestic and overseas media organizations.
• In addition to the Open House events, visitors are welcome to tour RERF’s facilities
upon request. In FY2019, as of the end of March 2020, 805 individuals from Japan
including students on school excursions, and 150 individuals from overseas toured the
RERF facilities in Hiroshima and Nagasaki.

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FY2019 RERF International Collaborative Activities
I. Participation in international collaborative
activities by RERF directors and staff
members

WHO-related activity
UNSCEAR-related activity
ICRP-related activity
IAEA-related activity
Medical checkup for A-bomb
survivors residing in South
Korea-related activity
OthersII. Acceptance of visitors from overseas forbriefing and training

1 person (Hiroshima)
7 people
Visitors related to HICARE
2 people
Visitors related to RERF
(International Exchange
Research Program)
1 person
Visitors related to MEXT
1 person
Visitors related to JICA

15 people

39 people
2 people
9 people
8 people

Visitors related to JAEA

45 people(Nagasaki)
Visitors related to
NASHIM

24 people

Total: 127 people(Hiroshima 103 people, Nagasaki 24 people)

Total: 27 people

I. Participation in international collaborative activities by RERF directors and staff
members (excluding participation in international scientific meetings)
In italics: Funding Organization
1. World Health Organization (WHO)-related activity (1 person)
RERF (hereinafter, all titles represent those at time of participation)
Kazunori Kodama, Executive Director, attended the 3rd collaboration meeting forJapanese WHO Collaboration Center. (Tokyo, September 6, 2020)
2. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR)-relat
ed collaborative activity (7 people)
1) National Institute of Radiological Sciences
Kotaro Ozasa, Department Chief of Epidemiology, attended the UNSCEAR domestic
committee meeting. (Tokyo, November 13, 2019)2) RERF(1) Kotaro Ozasa, Department Chief of Epidemiology, attended the 66th UNSCEAR
meeting. (Vienna, Austria, June 10-14, 2019)(2) Kazunori Kodama, Executive Director, and Kotaro Ozasa, Department Chief of
Epidemiology, attended online meetings on June 25, September 24, December 12,
2019, February 5 and March 27, 2020 as a member of the Japanese Working Groupof the Fukushima Follow-up Program.
(3) Kotaro Ozasa, Department Chief of Epidemiology, attended online meetings on
October 21, December 16, 2019, February 13, and March 27, 2020 as a member ofthe Ad Hoc Working Group on Effects and Mechanisms.

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(4) Alina Brenner, Senior Scientist, Department of Epidemiology, attended online
meetings on October 14, 2019 and February 11, March 9, April 2, 2020 as a lead
writer for UNSCEAR Epidemiological studies of Radiation and Cancer.
(5) Alina Brenner, Senior Scientist, Department of Epidemiology, attended an Expert
Group meeting for the UNSCEAR Report at NCI. (Rockville, USA, December 3-5,2019)
3. ICRP (International Commission on Radiological Protection)-related activity (2 people)(1) Kotaro Ozasa, Department Chief of Epidemiology, attended online conferences on
July 17-18, 2019 and March 31, 2020 as a member of ICRP Task Ggroup 115.
(2) Kotaro Ozasa, Department Chief of Epidemiology, participated as a member of the
ICRP Committee 1 and Task Group 115 (Risk and Dose Assessment forRadiological Protection of Astronauts). (Adelaide, Australia, November 16-26,
2019)
4. IAEA (International Atomic Energy Agency)-related activity (1 person)
Kazunori Kodama, Executive Director gave a lecture at HICARE/IAEA Workshop on
Biological and Internal Dosimetry: Recent advance and clinical application. (Hiroshima,February 21, 2020)
5. Medical checkup for A-bomb survivors residing in South Korea-related activity (1 person)
Nagasaki Prefectural Government’s medical checkup project for A-bomb survivors
residing in South Korea
Tomoki Nakamizo, Associate Senior Scientist, Department of Clinical Studies,
Nagasaki, together with the physicians and others from Nagasaki University Hospitaland the Nagasaki Genbaku Hospital participated in the medical checkup project for Abomb survivors residing in South Korea sponsored by the Nagasaki Prefectural
Government and provided health consultations for the A-bomb survivors in South
Korea. (Masan, South Korea, June 6–13, 2019)
6. Others (15 people)(1) Robert Ullrich, Vice Chairman, attended the 55th Annual Meeting of the National
Council on Radiation Protection and Measurements (NCRP). (Bethesda, USA,
April 1-2, 2019)(2) Robert Ullrich, Vice Chairman, attended the Gilbert W. Beebe Symposium “The
Future of Low-Dose Radiation Research in the United States.” (Washington DC,
USA, May 8-9, 2019)(3) Robert Ullrich, Vice Chairman, attended the Research Meetings with theresearchers at Oregon Health & Science University. (Portland, USA, June 9-10,
2019)(4) Benjamin French, Acting Department Chief of Statistics, visited the University ofWashington as a lecturer in a short course on joint modeling of longitudinal andsurvival data at the 2019 Summer Institute in Statistics for Clinical andEpidemiological Research. (Seattle, USA, July 26, 2019)(5) Robert Ullrich, Vice Chairman, attended the Research Meetings with theresearchers and gave a presentation at Oregon Health & Science University.
(Portland, USA, August 8, 2019)9

(6) Eric Grant, Associate Chief of Research, attended the first meeting of the“Scientific Committee 1-27” of the National Council on Radiation Protection andMeasurements (NCRP) as a committee member. (Bethesda, USA, August 13-14,
2019)(7) Robert Ullrich, Vice Chairman, attended for the 16th International Congress ofRadiation Research (ICRR). (Manchester, UK, August 25-29, 2019)(8) Kotaro Ozasa, Department Chief of Epidemiology, attended the 40th Anniversary
Meeting of Korean Society of Epidemiology. (Seoul Korea, September 19-20,
2019)(9) Robert Ullrich, Vice Chairman, attended the One Day Meeting “Discussion to
Develop Recommendations for Congressional Legislation on a Revised US
Research Program on the Health Effects on Low Dose Radiation, Including Those
Associated with Civilian Nuclear Energy. (Washington DC, USA, September 25,2019)(10) Hiromi Sugiyama, Senior Scientist, Department of Epidemiology, conducted acancer registration accuracy management training at Yangon General Hospital.
(Yangon, Myanmar, October 9-11, 2019).
(11) Benjamin French, Assistant Department Chief of Statistics, visited Korea
University’s study group on radiation epidemiology to give a research presentation
on atomic bomb survivor studies and a training course on longitudinal data analysis
methods. (Seoul, South Korea, October 28-29, 2019)(12) Eric Grant, Associate Chief of Research, attended the DOE Workshop. (San Diego,
USA, November 2, 2019)(13) Robert Ullrich, Vice Chairman, chaired session for the 65th Annual Meeting of the
Radiation Research Society. (San Diego, USA, November 3-6, 2019)(14) Kazunori Kodama, Executive Director, participated in a dispatch program fortraining on health care of the A-bomb survivors in Los Angeles. (Los Angeles,
USA, November 8-13, 2019)(15) Eric Grant, Associate Chief of Research, attended the “Scientific Committee 1-27”of the National Council on Radiation Protection and Measurements (NCRP).
(Bethesda, USA, January 15-16, 2020)
II. Acceptance of visitors from overseas for briefing and training (Total: 127 people)[Hiroshima: 103 people] In italics: Funding Organization
1. Visitors related to Hiroshima International Council for Health Care of the Radiation
Exposed (HICARE) (39 people)
1) South Korea (14 people）
Short-term training group of medical treatment for A-bomb survivors living in South
Korea(1) September 3, 2019: 7 trainees(2) October 29, 2019: 7 trainees
2) United States (6 people）(1) July 4, 2019: 3 trainees

10(2) December 19, 2019: 3 trainees
3) Others (19 people)(1) August 1, 2019: Hiroshima-ICAN Academy on Nuclear Weapons and Global
Security, 15 trainees from China, USA, France, England, Russia, and others(2) November 26–December 13, 2019: 1 trainee from Latvia(3) January 22, 2020: 3 trainees from Brazil
2. Visitors related to RERF (MHLW International Exchange Research Program) (2 people)
Training period: November 26-December 6, 2019(1) National Cancer Center, South Korea(2) Bangladesh Atomic Energy Commission
3. Visitors related to Ministry of Education, Culture, Sports, Science and Technology (MEXT)(9 people)
November 14, 2019: Young Leaders’ Program of Nagoya University Graduate Schoolof Medicine, trainees from Mongolia, Malaysia, Myanmar, Cambodia, Afghanistan, andothers
4. Visitors related to International Cooperation Agency (JICA) (8 people)
November 13, 2019: FY2019 JICA group training on “Tuberculosis control and drug
resistance in UHC age” at the request of the Research Institute of Tuberculosis, trainees
from Afghanistan, Congo, Philippines, Liberia, and Timor Leste and others
5. Visitors related to Japan Atomic Energy Agency (JAEA) (45 people)(1) July 5, 2019: JAEA’s Training Course on the Physical Protection of Nuclear
Material and Facilities, 23 trainees from Australia, Bangladesh, China, India,
Jordan, and others(2) October 25, 2019: JAEA’s Training Course on State Systems of Accounting forand control of Nuclear Material, 22 trainees form Australia, Bangladesh, India,
Indonesia, Iran, and others[Nagasaki: 24 people]
Visitors related to the Nagasaki Association for Hibakushas’ Medical Care (NASHIM) (24people)1） Chernobyl and Kazakhstan
July 23, 2019: 6 trainees
2） Korea(1) October 9, 2019: 8 trainees(2) January 15, 2020: 8 trainees
3) Brazil
January 15, 2020: 2 trainees

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FY2019 Joint programs between RERF and overseas researchers/researchorganizations
In italics: Funding Organization

1. Collaborative studies between RERF and US National Cancer Institute (NCI)(1) Under the research contract entered into by and between RERF and the US
National Cancer Institute (NCI), in which Kotaro Ozasa, Department Chief of
Epidemiology, serves as a responsible person of the RERF side, he is working on
analysis of solid cancer incidence risks in the LSS cohort, site-specific cancer
studies based on histopathological diagnoses, and preliminary reviews for genomic
analysis of thyroid cancer.
The following papers have been published (RERF authors underlined):
Cologne, JB, J. Kim, H. Sugiyama, B. French, H.M. Cullings, D.L. Preston, K.
Mabuchi, and K. Ozasa, Effect of Heterogeneity in Background Incidence on
Inference about the Solid-Cancer Radiation Dose Response in Atomic Bomb
Survivors. Radiat Res, 2019, 192 (4)Brenner AV, Sugiyama H, Preston DL, Sakata R, French B, Sadakane A, Cahoon
EK, Utada M, Mabuchi K, Ozasa K. Radiation risk of central nervous system
tumors in the Life Span Study of atomic bomb survivors, 1958-2009. Eur J
Epidemiol 2020/01/25 [Epub]:1-10
Sadakane A, French B, Brenner AV, Preston DL, Sugiyama H, Grant EJ, Sakata R,
Utada M, Cahoon EK, Mabuchi K, Ozasa K. Radiation and risk of liver, biliary
tract, and pancreatic cancers among atomic bomb survivors in Hiroshima andNagasaki: 1958-2009. Radiat Res 2019 (September); 192(3):299-310
Sakata R, Preston DL, Brenner AV, Sugiyama H, Grant EJ, Rajaraman P,
Sadakane A, Utada M, French B, Cahoon EK, Mabuchi K, Ozasa K. Radiationrelated risk of cancers of the upper digestive tract among Japanese atomic bomb
survivors. Radiat Res 2019 (September); 192(3):331-44
Sugiyama H, Misumi M, Brenner AV, Grant EJ, Sakata R, Sadakane A, Utada M,
Preston DL, Mabuchi K and Ozasa K, “Radiation risk of incident colorectal cancer
by anatomical site among atomic bomb survivors: 1958–2009”, Int J Cancer 2020
(February); 146(3):635-45(2) Dr. Dale Preston, Principal Scientist from Hirosoft International Corporation,
visited RERF to conduct collaborative studies including a solid cancer incidencerisks study of A-bomb survivors. (May 18–30, 2019)(3) Dr. Kiyohiko Mabuchi of Radiation Epidemiology Branch, NCI, visited RERF to
conduct NCI-funded collaborative studies including a site-specific cancer study.
(May 19–24, 2019)(4) Ritsu Sakata, Assistant Chief, and Alina Brenner, Senior Scientist, Department of
Epidemiology, are joining with the data of tumor of the central nervous systemfrom RERF as a part of the pooled analysis conducted by the scientists ofRadiation Epidemiology Branch, NCI.
(5) Ritsu Sakata, Assistant Department Chief of Epidemiology, is joining with the dataof radiation-associated thyroid cancers from RERF as a part of the pooled analysis
conducted by the scientists of Radiation Epidemiology Branch, NCI.

12

(6) Benjamin French, Assistant Chief, John Cologne, Senior Scientist, and Munechika
Misumi, Associate Senior Scientist, Department of Statistics, collaborated with the
RERF Department of Epidemiology and the US NCI in preparation of data andmethods for a series of upcoming papers on improved analyses of solid cancer
incidence and mortality. (Published papers listed in (1))(7) John Cologne, Senior Scientist, Department of Statistics, collaborated with the
RERF Department of Epidemiology and the US NCI in the preparation of a paper
dealing with methodological aspects of Life Span Study cancer incidence risk
analyses: “Effect of heterogeneity in background incidence on inference about thesolid-cancer radiation dose response in atomic-bomb survivors” (Radiat Res, 2019,
192 (4).
2. Collaboration between RERF and the/Asia Cohort Consortium (ACC)
Ritsu Sakata, Assistant Department Chief of Epidemiology, is joining the collaborative
project with the ACC entitled: Tobacco smoking, alcohol drinking, body mass index andrisk of rare cancers. (Hanoi, Vietnam, November 3-6, 2019)
3. Collaboration between RERF and Institute of Cancer Research, UK and US National
Institute of Environmental
Atsuko Sadakane, Senior Scientist, Department of Epidemiology, after she resigned andAlina Brenner, Senior Scientist, Department of Epidemiology, is joining withpremenopausal breast cancer data from RERF as a part of the pooled analysis conductedby Dr. Anthony Swerdlow of Institute of Cancer Research, UK, and Dr. Hazel Nicholsof US National Institute of Environmental.
The following paper has been published (RERF authors underlined):
Schoemaker MJ, Nichols HB, Wright LB, Brook MN, Jones ME, O'Brien KM, Adami
HO, Baglietto L, Bernstein L, Bertrand KA, Boutron-Ruault MC, Chen Y, Connor AE,
Dossus L, Eliassen AH, Giles GG, Gram IT, Hankinson SE, Kaaks R, Key TJ, Kirsh
VA, Kitahara CM, Larsson SC, Linet M, Ma H, Milne RL, Ozasa K, Palmer JR, Riboli
E, Rohan TE, Sacerdote C, Sadakane A, Sund M, Tamimi RM, Trichopoulou A, Ursin
G, Visvanathan K, Weiderpass E, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Sandler
DP, Swerdlow AJ. Adult weight change and premenopausal breast cancer risk: A
prospective pooled analysis of data from 628,463 women. Int J Cancer. 2020 Feb 3. doi:
10.1002/ijc.32892.
4. Collaboration between RERF and University of Washington
RERF entered into a research contract with the University of Washington (Departmentof Epidemiology and Department of Biostatistics), for which Benjamin French,
Assistant Department Chief of Statistics serves as coordinator. Under this contract,
RERF supports the training and education of MS and PhD students in epidemiology andbiostatistics, and conducts collaborative research with students and their advisors.
Research projects focus on analyses of cancer incidence and mortality outcomes in the
LSS, as well as the development of new statistical methods for analyzing LSS cohort
data. Research is ongoing and several papers are expected.
Visitors related to RERF and University of Washington partnership (5 people)
July 1-17, 2019: 1 visiting student (MS program in Epidemiology)
September 1-20, 2019: 1 visiting student (MS program in Epidemiology)
September 1-23, 2019: 1 visiting student (PhD program in Biostatistics)

13

November 5-8, 2019: 2 visiting students (MS and PhD program in Epidemiology)
5.

RERF international collaborative studies on statistical analyses(1) Munechika Misumi, Associate Senior Scientist, Department of Statistics, andHiromi Sugiyama, Senior Scientist, Department of Epidemiology, visited theInstitute of Radiation Protection at Helmholtz Zentrum in Germany. They shared
RERF’s latest research with Helmholtz Zentrum’s researchers and performed
mechanistic modeling of radiation-induced cancer. Moreover, they held adiscussion on future collaborative research. (Munich, Germany, November 27–
December 4, 2019)(2) Benjamin French, Acting Department Chief of Statistics, collaborated withresearchers at the University of Pennsylvania, Philadelphia, Pennsylvania, US, on
statistical methods for conducting sensitivity analyses of multiple dependentcomparisons in a single observational study. The following paper has been
published:
Karmakar B, French B, Small DS. Integrating the Evidence from Evidence Factors
in Observational Studies. Biometrika, 2019, 106(2):353-67.

6. RERF international collaborative studies on thyroid
Misa Imaizumi, Assistant Department Chief of Clinical Studies (Nagasaki), Waka
Ohishi, Department Chief of Clinical studies and Michiko Yamada, Division Chief ofRadiology of Department of Clinical Studies are joining with Adult Health Study datafrom RERF as a part of the pooled analysis of thyroid conducted by Dr. Rodondi of
University of Bern, Switzerland (Thyroid Studies Collaboration).

14令和元年度 外部資金研究一覧表
FY2019 External Research Funds
件数
Number of
Grants

外部機関名称
Name of Outside Organization

研究資金（資金拠出機関からの入金額）
Research funds (amount of funds
from funding organizations)¥2,270,000

厚生労働省
Ministry of Health, Labour and Welfare (MHLW)

2

独立行政法人 日本学術振興会（文部科学省所管の独立行政法人）
Japan Society for the Promotion of Science (JSPS)

7¥8,830,000

国立研究開発法人 国立がん研究センター
National Cancer Center

1

¥0

総合計

10

¥11,100,000[Independent administrative entity under the jurisdiction of the Ministry of Education, Culture,
Sports, Science and Technology (MEXT)]Grand total

注）・ 間接費を含む。
・ 研究分担者への配分額を含む。
* 研究協力者として研究参画のため、配分資金の配分なし。
Notes)
・ These amounts include indirect cost.
・ These amounts include subsidies allocated to collaborators.
* No research funds are allocated, because the RERF researcher takes part in the research as a cooperative investigator.

15*令和元年度 外部資金研究一覧表
FY2019 External Research Funds

研究のタイトル
Title of Research

委託組織の名前と場所及び研究グループのチーフ又は担当の主任研究者
Name and location of entrusting outside organization
Chief of research group or principal investigator in charge

放影研における研究者の名前
Investigator(s) at RERF

研究資金（資金拠出機関からの入金額）
Research funds(amount of funds
from fundingorganizations)

開始日
Initiation
Date

終了日
Termination
Date

関連RP
Related RPs¥650,000

April 1, 2019

March 31, 2020

RP 18-61

被爆者のがん罹患調査
Study of cancer incidence
among A-bomb survivors

研究協力者のため、研究資金の配分なし
Since this person is acooperative
investigator, researchfunds were notallocated to her.

April 1, 2019

March 31, 2020

RP-A2-15

日本人のがんの疫学研究
Epidemiological study of cancer
in Japanese population

関連性
Relationship to
RERF's mission

疫学部
Department of Epidemiology
1

都道府県がん登録の全国集計データと診療情報等との併用・突合によるがん統計整備及び活用促進の研究
Study to promote the usage and the maintenance ofthe cancer statistics by merging data of prefecturebased cancer registries and national cancer registry2

国内外研究連携基盤の積極的活用によるがんリスク評価及び予防ガイドライン提言に関する研究
Study of evaluation of carcinogenetic effects based on
active utilization of domestic and international
research consortia and proposal of cancer prevention
guidelines

厚生労働省・厚生労働科学研究費補助金
研究分担者「がん対策推進総合研究事業」(Collaborator)
研究代表者 松田 智大
杉山 裕美
国立研究開発法人国立がん研究センター
Hiromi Sugiyama
がん対策情報センターがん登録センター
全国がん登録室長
Health and Labour Sciences Research Grants (MHLW)
Promotion of Comprehensive Research Project for Cancer
Control
Tomohiro Matsuda
Section Head, Registry Section, National Cancer Registry,
Center for Cancer Registries, Center for Cancer Control andInformation Services, National Cancer Center

国立がん研究センター・国立がん研究センター研究
開発費
研究代表者 井上 真奈美
国立研究開発法人国立がん研究センター
社会と健康研究センター 予防研究部 部長
National Cancer Center
Funds for Cancer Research and Related Technology
Development
Manami Inoue
Chief, Division of Cohort Consortium Research,
Epidemiology and Prevention Group, Center for Public
Health Sciences,
National Cancer Center

研究協力者(Cooperative Investigator)
歌田 真依
Mai Utada16令和元年度 外部資金研究一覧表
FY2019 External Research Funds

研究のタイトル
Title of Research

委託組織の名前と場所及び研究グループのチーフ又は担当の主任研究者
Name and location of entrusting outside organization
Chief of research group or principal investigator in charge

研究資金（資金拠出機関からの入金額）
Research funds(amount of funds
from fundingorganizations)

開始日
Initiation
Date

終了日
Termination
Date

関連RP
Related RPs

研究分担者 (Collaborator)
山田 美智子Michiko Yamada¥1,620,000

April 1, 2019

March 31, 2020

RP 2-75

広範囲な医学的調査（生活習慣病）
Broad-based
medical research(Lifestyle disease)

研究代表者 (P.I.)
吉田 稚明
Noriaki Yoshida

直接経費(Direct cost)¥1,200,000

April 1, 2019

March 31, 2020

RP 6-70
RP 5-90
RP-S2-15
RP 5-02
RP-P2-19

がん研究（被爆者がん研究への応用）
Cancer research(Application to cancer researchamong A-bomb survivors)

放影研における研究者の名前
Investigator(s) at RERF

関連性
Relationship to
RERF's mission

臨床研究部
Department of Clinical Studies
1

2

生涯にわたる循環器疾患の個人リスクおよび集団のリスク評価ツールの開発を目的とした大規模コホート統合研究
A large-scale integrated cohort study to develop tools
to assess life-long individual/group risk of circulatory
diseases

被爆による造血器腫瘍発症に関与する分子機構の解明と今後への展望
Identification of molecular mechanisms related todevelopment of hematological malignancies byatomic-bomb

厚生労働省・厚生労働科学研究費補助金「循環器疾患・糖尿病等生活習慣病対策総合研究事業」

研究代表者 岡村 智教
慶應義塾大学医学部 教授
Health and Labour Sciences Research Grants (MHLW)
Comprehensive Research on Life-Style Related Diseases
including Cardiovascular Diseases and Diabetes Mellitus
Tomonori Okamura
Professor,
School of Medicine, Keio University

日本学術振興会・科学研究費助成事業「若手研究 」
研究代表者 吉田 稚明
JSPS Grant-in-Aid for Scientific Research
Early-Career Scientists
Noriaki Yoshida

間接経費(Indirect cost)¥360,00017令和元年度 外部資金研究一覧表
FY2019 External Research Funds

研究のタイトル
Title of Research

委託組織の名前と場所及び研究グループのチーフ又は担当の主任研究者
Name and location of entrusting outside organization
Chief of research group or principal investigator in charge

放影研における研究者の名前
Investigator(s) at RERF

研究資金（資金拠出機関からの入金額）
Research funds(amount of funds
from fundingorganizations)

関連性
Relationship to
RERF's mission

開始日
Initiation
Date

終了日
Termination
Date

April 1, 2019

March 31, 2020

RP 1-75
RP 18-59

LSS、遮蔽調査、線量調査
LSS, Shielding survey anddosimetry study

April 1, 2019

March 31, 2020

No RP

放射線の人に及ぼす影響及びこれによる疾病に関する調査研究事業
Research project on radiation
effects on humans and associateddiseases

関連RP
Related RPs

統計部
Department of Statistics
1 測定誤差を考慮した低線量被曝影響の統計的評価
Project to investigate effects of measurement errors in
low dose range

2 変化係数モデルの多変量化と北東大西洋のミンク

クジラの身体状況データへの適用
Multivariate varying coefficient model and its
application to physical state data of minke whale in thenortheast Atlantic Ocean

日本学術振興会・科学研究費助成事業「若手研究 」
研究代表者 三角 宗近
JSPS Grant-in-Aid for Scientific Research
Early-Career Scientists
Munechika Misumi

研究代表者 (P.I.)
三角 宗近
Munechika Misumi

日本学術振興会・科学研究費助成事業「基盤研究（C）」
研究代表者 山村 麻理子
JSPS Grant-in-Aid for Scientific Research
Scientific Research (C)Mariko Yamamura

研究代表者 (P.I.)
山村 麻理子Mariko Yamamura

直接経費(Direct cost)¥1,100,000
間接経費(Indirect cost)¥330,000

直接経費(Direct cost)¥900,000
間接経費(Indirect cost)¥270,000

広島大学の研究分担者への配分額は、上記の研究資金に含まれている。
The above amount includes funds allocated to thecollaborator at Hiroshima University.

18令和元年度 外部資金研究一覧表
FY2019 External Research Funds

研究のタイトル
Title of Research

委託組織の名前と場所及び研究グループのチーフ又は担当の主任研究者
Name and location of entrusting outside organization
Chief of research group or principal investigator in charge

放影研における研究者の名前
Investigator(s) at RERF

研究資金（資金拠出機関からの入金額）
Research funds(amount of funds
from fundingorganizations)

関連性
Relationship to
RERF's mission

開始日
Initiation
Date

終了日
Termination
Date

関連RP
Related RPs

April 1, 2019

March 31, 2020

RP 2-13

放射線被曝の遺伝的影響
Genetic effects ofradiation exposure

分子生物科学部
Department of Molecular Biosciences
1 胚発生期の自然発生変異に注目した高解像度な細胞系譜の解析
High resolution analysis of cell lineage by using postzygotic spontaneous mutations

日本学術振興会・科学研究費助成事業｢挑戦的研究（萌芽）｣研究代表者 内村 有邦
JSPS Grant-in-Aid for Scientific Research
Grant-in-Aid for Challenging Research (Exploratory)
Arikuni Uchimura

研究代表者 (P.I.)
内村 有邦
Arikuni Uchimura

直接経費(Direct cost)¥2,200,000
間接経費(Indirect cost)¥0

大阪大学の招へい教員の立場で研究代表者として研究全体に従事。当該科研費の管理および係る交付申請、実績報告書等の提出事務はすべて大阪大学が行う。
Engage whole work as PI and perform in Osaka
University, and all management of this funds andsubmission of reports, etc. are done by Osaka
University.

2 微量変異原評価を可能とする全ゲノム解読に基づく

日本学術振興会・科学研究費助成事業｢基盤研究（A）｣
研究代表者 権藤 洋一
東海大学 医学部基礎医学系 分子生命科学 教授
JSPS Grant-in-Aid for Scientific Research
Scientific Research (A)Yoichi Gondo
Professor, Department of Molecular Life Sciences,
Tokai University School of Medicine

研究協力者(Cooperative Investigator)
内村 有邦
Arikuni Uchimura

研究協力者のため、研究資金の配分なし
Since this person is acooperative
investigator, researchfunds were notallocated to him.

April 1, 2019

March 31, 2020

No RP

放射線被曝の遺伝的影響
Genetic effects ofradiation exposure

3 放射線発癌と体細胞変異に対する抗酸化ストレス転写

日本学術振興会・科学研究費助成事業「基盤研究（C） 」
研究代表者 田邉 修
JSPS Grant-in-Aid for Scientific Research
Scientific Research (C)Osamu Tanabe

研究代表者 (P.I.)
田邉 修
Osamu Tanabe
研究分担者 (Collaborator)
吉田 稚明（臨床研究部）
Noriaki Yoshida（Dept. Clinical Studies）

直接経費(Direct cost)¥900,000

April 1, 2019

March 31, 2020

RP-P3-19

放射線による発がんメカニズムの解明とその予防法の開発に貢献Contribution to the elucidation of
mechanisms of radiation
oncogenesis and to thedevelopment of methods toprevent it

網羅的自然発生突然変異検出系の開発
Development of comprehensive identification of
spontaneous mutations based on whole genome
sequencing applicable for the assessment of low-dose
mutagens

因子NRF2による防御作用の検討
Possible Roles of Oxidative Stress Response inProtection against Radiation-induced Mutagenesis andOncogenesis

19

間接経費
(Indirect cost)¥270,000令和元年度 外部資金研究一覧表
FY2019 External Research Funds

研究のタイトル
Title of Research

委託組織の名前と場所及び研究グループのチーフ又は担当の主任研究者
Name and location of entrusting outside organization
Chief of research group or principal investigator in charge

放影研における研究者の名前
Investigator(s) at RERF

研究資金（資金拠出機関からの入金額）
Research funds(amount of funds
from fundingorganizations)

開始日
Initiation
Date

終了日
Termination
Date

関連RP
Related RPs

関連性
Relationship to
RERF's mission

April 1, 2019

March 31, 2020

No RP

なし
None

分子生物科学部
Department of Molecular Biosciences
4 脊髄小脳変性症モデルマウスを用いたCRISPR/Cas13
による新しい核酸医療
New oligonucleotide therapy using CRISPR/Cas13 inspinocerebellar ataxia model mice

日本学術振興会・科学研究費助成事業｢基盤研究 (C)｣研究代表者 松田 由喜子
JSPS Grant-in-Aid for Scientific Research
Scientific Research (C)Yukiko Matsuda

研究代表者 (P.I.)
松田 由喜子Yukiko Matsuda

直接経費(Direct cost)¥1,300,000
間接経費(Indirect cost)¥0

広島大学原爆放射線医科学研究所の研究員（非常勤）の立場で研究代表者として当研究所の就業時間
外に広島大学において行われる。当該科研費の管理および係る交付申請、実績報告書等の提出事務はすべて広島大学が行う。
As the part-time researcher of RIRBM in Hiroshima
University, this project is performed at Hiroshima
University outside working hours. All management of
this funds and submission of reprots, etc. are done by
Hiroshima University.

20令和元年度 特別会計一覧表
FY2019 Special Funds
件数
Number of
Funds

資金合計
Amount of Funding
Total

厚生労働省
Ministry of Health, Labour and Welfare (MHLW)

3¥52,256,410

米国国立がん研究所（NCI）契約
U.S. National Cancer Institute (NCI） Contract

1¥11,818,439

広島県
Hiroshima Prefecture

1¥14,557,628

長崎県
Nagasaki Prefecture

1¥8,685,926

国立大学法人 京都大学（国立研究開発法人 日本医療研究開発機構委託事業の受託機関）
Kyoto University

1¥950,0007¥88,268,403

資金拠出機関名称
Name of Funding Agency[Contract project organization commissioned by the Japan Agency for Medical Research and Development (AMED)]

総合計

Grand total

注）・ 間接費を含む。
・ 研究分担者の配分額を含む。
Notes)
・ These amounts include indirect cost.
・ These amounts may include subsidies allocated to collaborators.

21

令和元年度 特別会計一覧表
FY2019 Special Funds
研究のタイトル
Title of Research

委託組織の名前と場所及び研究グループのチーフ又は担当の主任研究者
Name and location of entrusting outsideorganization/Chief of research group or principal
investigator in charge

放影研における契約者/
研究者の名前Investigator(s) at RERF

資金拠出機関からの入金額
Amount of Funds
from Funding
Agencies

開始日
Initiation
Date

終了日
Termination
Date

関連RP
Related RPs

放射線業務従事者の健康影響に関する疫学
研究
Epidemiological Study of Health Effects inFukushima Emergency Workers

厚生労働省・労災疾病臨床研究事業費補助金
研究代表者 大久保 利晃
独立行政法人労働者健康安全機構 労働安
全衛生総合研究所 特任統括研究員
Industrial Disease Clinical Research Grants(MHLW)
Toshiteru Okubo
Specially appointed chief researcher
National Institute of Occupational Safety and
Health, Japan Organization of Occupational
Health and Safety

研究分担者(Collaborative Investigators)
大石 和佳
Waka Ohishi
喜多村 紘子Hiroko Kitamura
小笹 晃太郎Kotaro Ozasa
研究協力者(Cooperative Investigators)
山田 美智子Michiko Yamada
飛田 あゆみAyumi Hida
今泉 美彩
Misa Imaizumi¥49,255,000

June 4,2019

March 31,2020

原爆放射線による健康影響に関する国際交流調査研究業務
International Exchange Program on Health
Effects of the Atomic Bomb Radiation

厚生労働省・委託事業
丹羽 太貫
MHLW Entrustment
Ohtsura Niwa

受託者(Contractor)
丹羽 太貫
Ohtsura Niwa

¥1,127,410

July 18,
2019

March 31,2020

放射線の人に及ぼす影響及びこれによる疾病に関する調査
研究の成果の管理、報告及び公表並びに研修を行うこと
To report and publicize theresults of research and studies,and to provide training on theeffects of radiation andassociated diseases in humans

原爆被爆者の生物試料の保管及び活用に関する研究事業Research Program on preservation and use of the3
A-bomb survivors' biosamples

厚生労働省・委託事業
丹羽 太貫
MHLW Entrustment
Ohtsura Niwa

受託者(Contractor)
丹羽 太貫
Ohtsura Niwa

¥1,874,000

October 9,
2019

March 31,2020

原爆被爆者の生物試料の保管
及び活用
Preservation and use of the Abomb survivors' biosamples

米国国立がん研究所（NCI）契約
米国メリーランド州ベセスダ、
米国国立がん研究所
NCI契約 75N91019P00167
主任研究者 小笹 晃太郎
U.S. National Cancer Institute (NCI) Contract
National Cancer Institute, Bethesda, Maryland,
USA
NCI Contract 75N91019P00167
Kotaro Ozasa

主任研究者(Program Director)
小笹 晃太郎Kotaro Ozasa
研究管理者(Project Managers)
エリック グラント
Eric J. Grant
リチャード スポスト
Richard Sposto

直接経費(Direct cost)¥7,878,961

August 1,
2019

July 31,2021

1

RP 6-15
RP 1-19
RP 1-20
RP 2-20

関連性
Relationship to
RERF's mission

2

原爆被爆者のがん罹患データの更新
Updated cancer incidence data in the atomicbomb survivors.

4

22

間接経費
(Indirect cost)¥3,939,478

RP 1-75
RP 18-61
RP 3-94
RP 6-02
RP 1-06
RP 4-07
RP 5-08
RP 6-10
RP-S2-15
RP-S2-16
RP-P1-16

放射線被曝の健康影響
Health effects of radiation
exposure

がんの疫学研究、
LSS、胎内被爆者、
F1集団
Epidemiological study of cancer,
LSS, in utero , andF1 populations

令和元年度 特別会計一覧表
FY2019 Special Funds
委託組織の名前と場所及び研究グループのチーフ又は担当の主任研究者
Name and location of entrusting outsideorganization/Chief of research group or principal
investigator in charge

放影研における契約者/
研究者の名前Investigator(s) at RERF

がん登録推進事業
Cancer Registry Promotional Project

広島県・委託事業
丹羽 太貫Hiroshima Prefecture
Ohtsura Niwa

受託者(Contractor)
丹羽 太貫
Ohtsura Niwa

長崎県がん登録・評価事業
Nagasaki Prefecture Cancer Registry Program

長崎県・委託事業
丹羽 太貫Nagasaki Prefecture
Ohtsura Niwa

骨髄異形成症候群（MDS）のオミックス解
析による治療反応性および病型進展の新たなバイオマーカーの同定とその実用化に関する研究Study for identification of new biomarkers forpredicting therapeutic responsiveness anddisease type progression of myelodysplastic
syndrome (MDS) by omics analyses and thepractical use

日本医療研究開発機構（AMED）研究費「革新的がん医療実用化研究事業」
研究代表者 小川 誠司
京都大学大学院医学研究科 教授
Japan Agency for Medical Research andDevelopment (AMED) Grants
Practical Research for Innovative Cancer
Control
Seishi Ogawa
Professor,
Kyoto University Graduate School of
Medicine

研究のタイトル
Title of Research

5

6

7

資金拠出機関からの入金額
Amount of Funds
from Funding
Agencies

関連性
Relationship to
RERF's mission

開始日
Initiation
Date

終了日
Termination
Date¥14,557,628

April 1,
2019

March 31,2020

RP18-61
RP29-60
RPs18-61&
29-60附属書

がんの疫学研究、
LSS、胎内被爆者、
F1集団
Epidemiological study of cancer,
LSS, in utero, andF1 populations

受託者(Contractor)
丹羽 太貫
Ohtsura Niwa

¥8,685,926

April 1,
2019

March 31,2020

RP18-61
RP29-60
RPs18-61&
29-60附属書

がんの疫学研究、
LSS、胎内被爆者、
F1集団
Epidemiological study of cancer,
LSS, in utero, andF1 populations

研究分担者 (Collaborator)
今泉 美彩
Misa Imaizumi
研究開発協力者(Cooperative Investigators)
飛田 あゆみAyumi Hida
ベンジャミン フレンチBenjamin French
三角 宗近
Munechika Misumi
大石 和佳
Waka Ohishi
吉田 稚明
Noriaki Yoshida
副島 幹男
Mikio Soejima

直接経費(Direct cost)¥730,770

April 1,
2019

March 31,2020

RP 1-17

被爆者のがん研究
Cancer research in atomic bomb
survivors

23

間接経費(Indirect cost)¥219,230

関連RP
Related RPs

II. Operation and management of RERF
1. Research Resource Center
The Research Resource Center (RRC) is a core RERF infrastructure to store, document,
and index all RERF resources and to integrate research data with biosample data topromote research.
Seen broadly, there are three main areas of development.
1. A data/biosample integration project
2. An archiving/preservation project
3. Development of the Office of Collaborative Research and Grant Support
Dr. Robert Grossman (University of Chicago) made a visit to RERF to discuss the “Gen3”
Data Commons software that has been developed by his group; at the end of his visit, theinitiation of a pilot project was agreed upon. Dr. Christy Henshaw (Wellcome Trust, UK)visited to discuss Wellcome’s online digital presence and technical details of theiroperations. On the advice of the Gen3 technical team, the technical specifications ofservers were determined and after an open bidding process, the servers were purchased andinstalled. Three persons from the Gen3 team came to RERF for a one-week visit to teach
RERF personnel how to install and use the Gen3 software. A number of scanning vendors
were invited to RERF to view our paper materials and gain an understanding of RERF’s
long-term vision of scanning all paper materials. Two secure computing rooms with video
surveillance and biometric entry doors were constructed on RERF’s premises to facilitate
human genome research using off-site super computers (that require security and audit
trails for use). The “Preparatory Committee for Establishment of the Research Resource
Center” was officially instantiated. The committee reviewed and accepted the “RRC White
Paper” and requested four subcommittees be created to help with early RRC decisions andtasks. Two persons were recruited to ITD’s technology team. These persons are recent
computer science graduates from local universities and should begin working for RERF in
2020. A number of ITD staff attended conferences on Open Library Services, Open Data
Initiatives, and other relevant topics.
In addition, the RERF Data Management/Documentation Committee established a “Policy
on Submitting Human Genome Data to a Public Database.” This forward-looking policy
will allow genome data developed by RERF to be deposited into public databases after
adhering to a number of strict, yet reasonable, rules and procedures.
2. Introduction of an attendance and work management system
With the enforcement of a work-style reform law enacted in June 2018, we started
procedures for introducing an attendance and work management system in April 2019. The
aim of doing so is to monitor employee work hours in an objective way, improving thework efficiency of attendance management duties by creating workflows for the various
leave applications and the overtime report, as well as streamlining salary calculations bylinking attendance information to the payroll system. It will be challenging to select amodel simply by comparing prices as this system requires special features, such as
Japanese-English support and effort management by RERF. For this reason, acomprehensive evaluation method that covers both performance and price was adopted forthe bidding. After announcing a public notice of a request for submission of materials,
preparing specifications, and examining eligible vendors for open competitive bidding, a24

public announcement of the tender was made. However, there were no bidders by thetender deadline of February 4, 2020, and the bid was unsuccessful.
3. Facility upgrades(1) Facility upgrades to the Hiroshima Laboratory
The rooftop waterproofing of Units I and J, which are not Quonset-style buildings, wasdone more than 20 years ago. If leaks had occurred, the paper materials stored at the Master
File Section of the Epidemiology Department and the Library and Archive Section of theInformation Technology Department might have been damaged. The air conditioners
installed at Units B, Da, F, G, and J have been remarkably deteriorated and had failed
repeatedly. In addition, maintenance in the event of failure was expected to be difficult, as
global warming prevention led to the end of R22 refrigerant’s production at the end of
December 2019. R22 is a widely used air conditioner refrigerant in Japan. Therefore, it wasnecessary to carry out replacement work. RERF received a government subsidy from the
Ministry of Health, Labor and Welfare for the maintenance of facilities for health andhygiene facilities for FY2019 (52.759 million yen), and undertook the rooftop renovation
work of Units I and J, and the replacement of air conditioners at Units B, Da, F, G, and J.
(2) Facility upgrades to the Nagasaki Laboratory
More than 16 years have passed since the exterior walls of the building of the Nagasaki
Laboratory were painted. The exterior wall renovation work is underway to prevent waterleakage due to deterioration and to prevent tiles from falling and water leakages due tocracks in the exterior wall tiles. The durability of the sealant is about 10 years. The
renovation work was completed. The construction cost is 35.651 million yen, but RERF
and the Nagasaki Prefectural Education Association will split the cost, as the association
shares the Nagasaki Laboratory building. Therefore, RERF will pay 17.825 million yen.
4. Revision of the rules and regulations
The following regulations were revised to enhance this public interest incorporated
foundation’s operational framework: Employee Administrative Procedures for Using Taxis and Administrative Procedures for
Reimbursing the Travel Expenses of Study Participants [Effective date: April 1, 2019]
RERF established new procedures concerning employees’ taxi use and reimbursementof the travel expenses of study participants.
 Internal Regulations Concerning Formal Meals at Meetings [Effective date: April 1,
2019]
RERF established new internal regulations to clarify how to handle and process formal
meal expenses for meetings attended by external stakeholders.
 Regulations for Protection of Personal Information [Effective date: June 4, 2019]
Revisions made to the Act on the Protection of Personal Information in May 2017
necessitated the revision of these internal regulations.
 Rules of Procedure of the Board of Councilors [Effective date: June 21, 2019]
Articles were added to clarify the roles played by the Councilors.
 Operational Procedures of RERF Institutional Review Board [Effective date: July 1,
2019]
To respond to revisions made to the Ethical Guidelines for Medical and Health Research
Involving Human Subjects and the Guidelines for Human Genome/Gene Analysis

25*

Involving Human Subjects and the Guidelines for Human Genome/Gene Analysis
Research (effective 2017), necessary items were added.
 Regulations related to radioisotopes (RI) including the Regulations for Prevention ofRadiation Hazards [Effective date: August 2, 2019]
Pursuant to the amendments to the Act on Restrictions of Radioisotopes, which waspromulgated in April 2017, the regulations related to RI were comprehensively revised
to match the intent of the amended law.
 Work-Related Ethics Regulations for Employees [Effective date: December 1, 2019]
RERF established new regulations to maintain relevant workplace ethics.
 Guidelines on Procedures for Administering Employees’ Outside Activities [Effective
date: January 1, 2020]
These guidelines were established to clarify time management and procedures forreceiving remuneration when the RERF employees conduct outside activities.
 Guidelines for the Entrustment of Research and Development [Effective date: February
1, 2020]
RERF developed guidelines to clarify all procedures for conducting entrusted research.
5. Investigation on the relocation of Hiroshima Laboratory
We reviewed the requirements of post-relocation research facilities in terms of function,
floor space, and relocation costs, based on a report on Hiroshima Laboratory’s relocation
investigation conducted in FY2018.

26

Appended documents to FY2019 report of activities

There were no items considered to be important matters for supplementing thecontents of the FY2019 report of activities.

27