Publication list of Hisanori Imai as of July 08, 2021 (Only written in English)
Ⅰ. Original Articles
1: Sugimoto M, Kondo M, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Imai H, Nakamura M,Gabazza EC. Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macularedema. Sci Rep. 2021;11(1):10449. doi: 10.1038/s41598-021-89870-5.
2: Yamada H, Imai H, Tetsumoto A, Hayashida M, Otsuka K, Miki A, Kusuhara S, Nakamura M.
Cystotomy with or without fibrinogen clot removal for refractory cystoid macular edema secondary tobranch retinal vein occlusion. Sci Rep. 2021;11(1):8460. doi: 10.1038/s41598-021-88149-z.
3: Maki H, Mori S, Imai H, Yamada H, Otsuka K, Miki A, Kusuhara S, Nakamura M. Autologous Scleral
Pocket Technique for Ahmed Glaucoma Valve Implantation with Pars Plana Tube Insertion for
Neovascular Glaucoma. J Clin Med. 2021;10(8):1606. doi: 10.3390/jcm10081606.
4: Imai H, Tetsumoto A, Yamada H, Hayashida M, Otsuka K, Miki A, Kusuhara S, Nakamura M. LONGTERM EFFECT OF CYSTOTOMY WITH OR WITHOUT THE FIBRINOGEN CLOT REMOVALFOR REFRACTORY CYSTOID MACULAR EDEMA SECONDARY TO DIABETIC
RETINOPATHY. Retina. 2021;41(4):844-851. doi: 10.1097/IAE.0000000000002921.
5: Chubachi A, Miki A, Hayashida M, Sakamoto M, Imai H, Kusuhara S, Nakamura M. Clinical Factors
Associated with Low-Contrast Visual Acuity after Reduced-Fluence Photodynamic Therapy inPatients with Resolved Central Serous Chorioretinopathy and Good Baseline Visual Acuity.
Pharmaceuticals (Basel). 2021;14(4):303. doi: 10.3390/ph14040303.
6: Kim KW, Kusuhara S, Katsuyama-Yoshikawa A, Nobuyoshi S, Kitamura M, Mori S, Sotani N, Ueda
K, Matsumiya W, Miki A, Kurimoto T, Imai H, Nakamura M. Changes in Gene Expression Profilingand Phenotype in Aged Multidrug Resistance Protein 4-Deficient Mouse Retinas. Antioxidants (Basel).
2021;10(3):455. doi: 10.3390/antiox10030455.
7: Zolov SN, Imai H, Losiewicz MK, Singh RSJ, Fort PE, Gardner TW. Insulin-like growth factor-2
regulates basal retinal insulin receptor activity. J Biol Chem. 2021;296:100712. doi:
10.1016/j.jbc.2021.100712.
8: Miki A, Kusuhara S, Otsuji T, Kawashima Y, Miki K, Imai H, Nakamura M, Tsujikawa A.
Photodynamic therapy combined with anti-vascular endothelial growth factor therapy forpachychoroid neovasculopathy. PLoS One. 2021;16(3):e0248760. doi: 10.1371/journal.pone.0248760.
9: Imai H, Tetsumoto A, Yamada H, Nakamura M. Impact of different manufacturers and gauge sizes on
the performance of backflush needle. Sci Rep. 2020;10(1):21452. doi: 10.1038/s41598-020-78668-6.
10: Imai H, Tetsumoto A, Inoue S, Takano F, Yamada H, Hayashida M, Otsuka K, Miki A, Kusuhara S,Nakamura M. Intraoperative Three-Dimensional Fluorescein Angiography-Guided Pars PlanaVitrectomy for the Treatment of Proliferative Diabetic Retinopathy: The Maximized Utility of theDigital Assisted Vitrectomy. Retina. 2020. doi: 10.1097/IAE.0000000000002805. Epub ahead of print.
11: Matsumae H, Morizane Y, Yamane S, Yanagisawa S, Sakurai T, Kobori A, Imai H, Kanzaki Y,Suzuki E, Kadonosono K, Hayashi A, Shiraga F, Kuriyama S. Inverted Internal Limiting Membrane
Flap versus Internal Limiting Membrane Peeling for Macular Hole Retinal Detachment in HighMyopia. Ophthalmol Retina. 2020;4(9):919-926. doi: 10.1016/j.oret.2020.03.021.
12: Katsuyama A, Kusuhara S, Asahara SI, Nakai SI, Mori S, Matsumiya W, Miki A, Kurimoto T, ImaiH, Kido Y, Ogawa W, Nakamura M. En face slab optical coherence tomography imaging successfully
monitors progressive degenerative changes in the innermost layer of the diabetic retina. BMJ OpenDiabetes Res Care. 2020;8(1):e001120. doi: 10.1136/bmjdrc-2019-001120.
13: Hayashida M, Miki A, Nakai S, Matsumiya W, Imai H, Kusuhara S, Nakamura M. Predictive factorsof metamorphopsia after reduced-fluence photodynamic therapy in patients with central serous

chorioretinopathy with good baseline visual acuity. PLoS One. 2020;15(10):e0240557. doi:
10.1371/journal.pone.0240557.
14: Hayashida M, Miki A, Nakai S, Matsumiya W, Imai H, Kusuhara S, Honda S, Nakamura M. Geneticfactors associated with treatment response to reduced- fluence photodynamic therapy for chronic
central serous chorioretinopathy. Mol Vis. 2020;26:505-509.
15: Imai H, Otsuka K, Tetsumoto A, Miki A, Nakamura M. EFFECTIVENESS OF EN BLOCREMOVAL OF FIBRINOGEN-RICH COMPONENT OF CYSTOID LESION FOR THE
TREATMENT OF CYSTOID MACULAR EDEMA. Retina. 2020;40(1):154-159. doi:
10.1097/IAE.0000000000002359.
16: Tetsumoto A, Imai H, Hayashida M, Otsuka K, Matsumiya W, Miki A, Nakamura M. The
comparison of the surgical outcome of 27-gauge pars plana vitrectomy for primary rhegmatogenous
retinal detachment between air and SF6 gas tamponade. Eye (Lond). 2020;34(2):299-306. doi:
10.1038/s41433-019-0726-2.
17: Shinkai Y, Oshima Y, Yoneda K, Kogo J, Imai H, Watanabe A, Matsui Y, Suzuki K, Sotozono C;
27G Vitrectomy Study Group. Multicenter survey of sutureless 27-gauge vitrectomy for primaryrhegmatogenous retinal detachment: a consecutive series of 410 cases. Graefes Arch Clin Exp
Ophthalmol. 2019;257(12):2591-2600. doi: 10.1007/s00417-019-04448-2.
18: Tetsumoto A, Imai H, Otsuka K, Matsumiya W, Miki A, Nakamura M. Clinical factors contributing
to postoperative aqueous flare intensity after 27-gauge pars plana vitrectomy for the primaryrhegmatogenous retinal detachment. Jpn J Ophthalmol. 2019;63(4):317-321. doi: 10.1007/s10384019-00672-9.
19: Hayashida M, Miki A, Imai H, Otsuka K, Azumi A, Nakamura M. Impact of Early Vitrectomy for
Dense Vitreous Hemorrhage of Unknown Etiology. Ophthalmologica. 2019;242(4):234-238. doi:
10.1159/000501723.
20: Otsuka K, Imai H, Fujii A, Miki A, Tagami M, Azumi A, Nakamura M. Comparison of 25- and 27Gauge Pars Plana Vitrectomy in Repairing Primary Rhegmatogenous Retinal Detachment. JOphthalmol. 2018;2018:7643174. doi: 10.1155/2018/7643174.
21: Honda S, Miki A, Kusuhara S, Imai H, Nakamura M. CHOROIDAL THICKNESS OF CENTRALSEROUS CHORIORETINOPATHY SECONDARY TO CORTICOSTEROID USE. Retina.
2017;37(8):1562-1567. doi: 10.1097/IAE.0000000000001380.
22: Otsuka K, Imai H, Miki A, Nakamura M. Impact of postoperative positioning on the outcome of pars
plana vitrectomy with gas tamponade for primary rhegmatogenous retinal detachment: comparison
between supine and prone positioning. Acta Ophthalmol. 2018;96(2):e189-e194. doi:
10.1111/aos.13482.
23: Ubukata Y, Imai H, Otsuka K, Nishizaki M, Hara R, Uenishi M, Azumi A, Nakamura M. The
Comparison of the Surgical Outcome for the Full-Thickness Macular Hole with/without Lamellar
Hole-Associated
EpiretinalProliferation.
JOphthalmol.
2017;2017:9640756.
doi:
10.1155/2017/9640756.
24: Matsumiya W, Honda S, Otsuka K, Miki A, Nagai T, Imai H, Kusuhara S, Nakamura M. One-year
outcome of combination therapy with intravitreal aflibercept and verteporfin photodynamic therapy
for polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 2017;255(3):541-548. doi:
10.1007/s00417-016-3500-1.
25: Imai H, Fujii A, Tani E, Azumi A. Wound Integrity of 2.0 mm Transconjunctival Single-Plane
Sclerocorneal Incision: A Comparison between a Motorized Injector with/without Pause Time and a
Manual Injector. J Ophthalmol. 2016;2016:8129298. doi: 10.1155/2016/8129298.
26: Imai H, Misra GP, Wu L, Janagam DR, Gardner TW, Lowe TL. Subconjunctivally Implanted
Hydrogels for Sustained Insulin Release to Reduce Retinal Cell Apoptosis in Diabetic Rats. Invest
Ophthalmol Vis Sci. 2015;56(13):7839-46. doi: 10.1167/iovs.15-16998.

27: Imai H, Tagami M, Azumi A. Scleral buckling for primary Rhegmatogenous retinal detachment using
noncontact wide-angle viewing system with a cannula- based 25 G chandelier endoilluminator. Clin
Ophthalmol. 2015;9:2103-7. doi: 10.2147/OPTH.S91339.
28: Matsumiya W, Honda S, Otsuka K, Miki A, Nagai T, Imai H, Kusuhara S, Nakamura M. Comparisonof the Effectiveness and Prognostic Factors of Intravitreal Ranibizumab between Typical Neovascular
Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy over 24 Months ofFollow-Up. Ophthalmologica. 2015;234(1):33-9. doi: 10.1159/000431000.
29: Tagami M, Matsumiya W, Imai H, Kusuhara S, Honda S, Azumi A. Autologous antibodies to outer
retina in acute zonal occult outer retinopathy. Jpn J Ophthalmol. 2014;58(6):462-72. doi:10.1007/s10384-014-0347-z.
30: Fujii A, Imai H, Kanai M, Azumi A. Effect of intravitreal aflibercept injection for age-related maculardegeneration with a retinal pigment epithelial tear refractory to intravitreal ranibizumab injection. Clin
Ophthalmol. 2014;8:1199-202. doi: 10.2147/OPTH.S65810.
31: Kaiser JM, Imai H, Haakenson JK, Brucklacher RM, Fox TE, Shanmugavelandy SS, Unrath KA,
Pedersen MM, Dai P, Freeman WM, Bronson SK, Gardner TW, Kester M. Nanoliposomal
minocyclineforoculardrugdelivery.
Nanomedicine.
2013;9(1):130-40.
doi:
10.1016/j.nano.2012.03.004.
32: Bessho H, Honda S, Imai H, Negi A. Natural course and funduscopic findings of polypoidal choroidal
vasculopathy in a Japanese population over 1 year of follow-up. Retina. 2011;31(8):1598-602. doi:
10.1097/IAE.0b013e31820d3f28.
33: Tagami M, Kusuhara S, Imai H, Honda S, Tsukahara Y, Negi A. Impact of intravitreal injection oftissue plasminogen activator on full-field electroretinogram in patients with macular oedema
secondary to retinal vein occlusion. Ophthalmologica. 2011;226(2):81-6. doi: 10.1159/000326242.
34: Tagami M, Kusuhara S, Imai H, Uemura A, Honda S, Tsukahara Y, Negi A. MRP4 knockdown
enhances migration, suppresses apoptosis, and produces aggregated morphology in human retinal
vascular endothelial cells. Biochem Biophys Res Commun. 2010;400(4):593-8. doi:
10.1016/j.bbrc.2010.08.109.
35: Honda S, Imai H, Yamashiro K, Kurimoto Y, Kanamori-Matsui N, Kagotani Y, Tamura Y,Yamamoto H, Ohoto S, Takagi H, Uenishi M, Negi A. Comparative assessment of photodynamictherapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: amulticenter study in Hyogo prefecture, Japan. Ophthalmologica. 2009;223(5):333-8. doi:
10.1159/000221837.
36: Nagai T, Imai H, Honda S, Negi A. Antiangiogenic effects of bisphosphonates on laser-induced
choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2007;48(12):5716-21. doi:
10.1167/iovs.07-1023.
37: Imai H, Honda S, Kondo N, Ishibashi K, Tsukahara Y, Negi A. The upregulation of angiogenic gene
expression in cultured retinal pigment epithelial cells grown on type I collagen. Curr Eye Res.
2007;32(10):903-10. doi: 10.1080/02713680701604749.
38: Tsukahara Y, Honda S, Imai H, Kondo N, Fujii S, Yokoyama N, Hirata A, Kawaji T, Fukushima M,Tanihara H, Negi A. Autologous plasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: apreliminary trial. Am J Ophthalmol. 2007;144(1):139-41. doi: 10.1016/j.ajo.2007.03.020.
39: Imai H, Honda S, Nakanishi Y, Yamamoto H, Tsukahara Y, Negi A. Different transitions ofmultifocal electroretinogram recordings between patients with age-related macular degeneration andpolypoidal choroidal vasculopathy after photodynamic therapy. Br J Ophthalmol. 2006;90(12):152430. doi: 10.1136/bjo.2006.092783.

Ⅱ. Case reports
1: Sakai D, Imai H, Nakamura M. Multiple Intravitreal Liposomal Amphotericin B for a Case of Candidaglabrata Endophthalmitis. Case Rep Ophthalmol 2021;12(2):485–491. doi: 10.1159/000511594.
2: Maki H, Imai H, Yamada H, Tetsumoto A, Hayashida M, Otsuka K, Miki A, Nakamura M. The longterm effect of cystotomy with fibrinogen clot removal for a cystoid macular edema secondary toidiopathic macular telangiectasia type 1: a case report. Retin Cases Brief Rep. 2021;Publish Ahead ofPrint. doi: 10.1097/ICB.0000000000001117. Epub ahead of print.
3: Imai H, Tetsumoto A, Yamada H, Hayashida M, Otsuka K, Miki A, Nakamura M. Intraoperative threedimensional fluorescein angiography-guided pars plana vitrectomy for branch retinal vein occlusion.
Retin Cases Brief Rep. 2020. doi: 10.1097/ICB.0000000000001091. Epub ahead of print.
4: Inoue S, Imai H, Tetsumoto A, Otsuka K, Nakamura M. A Rare Case of Lens- Induced Uveitis with
Proliferative Vitreoretinopathy and Massive Encapsulation of Fallen Nuclear Material. Case Rep
Ophthalmol. 2020;11(2):436-441. doi: 10.1159/000508913.
5: Tetsumoto A, Imai H, Miki A, Nakamura M. A CASE OF RETINAL METASTASIS OFLARYNGEALSQUAMOUSCELL
CARCINOMAWITHHISTOPATHOLOGICCONFIRMATION BY VITRECTOMY-ASSISTED EN BLOCK EXTRACTION. Retin Cases Brief
Rep. 2020;14(2):127-130. doi: 10.1097/ICB.0000000000000666.
6: Obata S, Miki A, Imai H, Nakamura M. Bilateral corneal denting after surgery under generalanesthesia: A case report. Am J Ophthalmol Case Rep. 2018;10:290-292. doi:
10.1016/j.ajoc.2018.04.011.
7: Iwakawa Y, Imai H, Kaji H, Mori Y, Ono C, Otsuka K, Miki A, Oishi M. Autologous Transplantationof the Internal Limiting Membrane for Refractory Macular Hole following Ruptured Retinal Arterial
Macroaneurysm: A Case Report. Case Rep Ophthalmol. 2018;9(1):113-119. doi: 10.1159/000485914.
8: Fukumoto T, Oka M, Masaki T, Sakaguchi M, Fukunaga A, Norose K, Sarayama Y, Imai H, Nishigori
C. Cutaneous Rosai-Dorfman disease associated with uveitis. Eur J Dermatol. 2017;27(1):85-86. doi:
10.1684/ejd.2016.2885.
9: Bessho H, Imai H, Azumi A. The Histopathological Finding of the Surgically Extracted AtypicalDome-Shaped Choroidal Osteoma. Case Rep Ophthalmol Med. 2017;2017:2874823. doi:
10.1155/2017/2874823.
10: Imai H, Azumi A. The Expansion of RPE Atrophy after the Inverted ILM Flap Technique for aChronic Large Macular Hole. Case Rep Ophthalmol. 2014;5(1):83-6. doi: 10.1159/000360693.
11: Shimoyama T, Imai H, Honda S, Negi A. A case of choroidal neovascularization secondary tounilateral retinal pigment epithelium dysgenesis. Case Rep Ophthalmol. 2014;5(1):34-7. doi:10.1159/000358426.
12: Otsuka K, Imai H, Shimoyama T, Nagai T, Honda S, Azumi A. Recurrence of macular hole retinal
detachment after intravitreal ranibizumab injection for the treatment of choroidal neovascularizationfrom the remaining macular hole edge. Case Rep Ophthalmol. 2012;3(3):424-7. doi:
10.1159/000346041.
13: Imai H, Honda S, Tsukahara Y, Negi A. Macular edema formation and deterioration of retinal
function after intravitreal bevacizumab injection for proliferative diabetic retinopathy. Case Rep
Ophthalmol. 2011;2(3):314-8. doi: 10.1159/000332830.
14: Matsumiya W, Honda S, Imai H, Kusuhara S, Tsukahara Y, Negi A. A Case of Bilateral Macular
Holes Showing Onset and Spontaneous Closure over Very Short Intervals. Case Rep Ophthalmol.
2010;1(2):47-52. doi: 10.1159/000320586.
15: Imago M, Imai H, Nakanishi Y, Azumi A. Optical coherence tomography for monitoring the processof Candida endophthalmitis. Acta Ophthalmol. 2009;87(6):680-2. doi: 10.1111/j.17553768.2008.01297.x.
16: Imai H, Azumi A, Nagai T, Yamamoto H, Negi A, Ohbayashi C. A case of ocular toxoplasmosis:
direct proof of the protozoan infection by retinal biopsy. Retin Cases Brief Rep. 2008;2(1):76-9. doi:10.1097/01.iae.0000249391.22195.bd.
17: Imai H, Kusuhara S, Nakanishi Y, Teraoka Escaño MF, Yamamoto H, Tsukahara Y, Negi A. A caseof POEMS syndrome with cystoid macular edema. Am J Ophthalmol. 2005;139(3):563-6. doi:10.1016/j.ajo.2004.09.016.

Ⅲ. Review Article
1: Imai H, Singh RSJ, Fort PE, Gardner TW. Neuroprotection for diabetic retinopathy. Dev Ophthalmol.
2009;44:56-68. doi: 10.1159/000223946.