NHO 栃木医療センター 臨床研究部 加藤 徹（2014.1.1～）【研究業績】
治験
・第一三共エドキサバン 15mg 試験（心房細動治験）
・アストラゼネカ pEF 試験（心不全国際治験）
国立病院機構（NHO）循環器グループ 多施設共同研究
・ANOX 研究（代表：京都医療センター）
・EXCEED-J 研究（代表：京都医療センター）・OPTION-CIN 研究（代表：横浜医療センター）・PREHOSP 研究（代表：京都医療センター）
・禁煙外来 YOKUKANSAN 研究（代表：京都医療センター）
・禁煙外来管理栄養士介入研究（代表：京都医療センター）

その他の医師主導型 多施設共同研究
・VAL-THUNDER 研究（代表：獨協医科大学 井上教授）
・EXPAND 研究（代表：東北大学 下川教授）
・PRIZE 研究（代表：佐賀大学 野出教授）
・RESPECT-EPA 研究（代表：順天堂大学 代田教授）
・AFIRE 研究（代表：国立循環器病センター・熊本大学 小川教授）
・アピキサバン研究（代表：獨協医科大学 堀中教授）
・動脈硬化危険因子（代表：自治医科大学 小谷教授）
・禁煙外来・脂質異常研究（代表：国際医療福祉大学 梅田教授）
・歯周病研究（代表：当院歯科口腔外科 内山部長 / 自治医科大学 小谷教授）
・CHD 研究（代表：佐賀大学 野出教授 / 琉球大学 植田教授）
・ANAFIE 研究（代表：心臓血管研究所 山下武志院長）
・EXCITED-UA 研究（代表：獨協医科大学 井上教授）

【英文論文業績】
Optimal uric acid reduction to improve vascular endothelial function in patientswith chronic heart failure complicated by hyperuricemia
Hypertens Res. 2023 Mar;46(3):688-696.
IF=5.525
Randomized double-blind placebo-controlled multicenter trial for the efects of apolyherbal remedy, Yokukansan (YiganSan), in smokers with depressive
tendencies
BMC Complementary Medicine and Therapies (2022) 22:311
IF: 2.838
Effects of smoking cessation using varenicline on the serum concentrations ofoxidized high-density lipoprotein: Comparison with high-density lipoproteincholesterol
PLOS One 2022 Nov 30;17(11):e0277766.
IF: 3.73
Cardiovascular Factors Associated with COVID-19 from an International
Registry of Primarily Japanese Patients
Diagnosis.Sept 2022
IF: 3.992
Effects of High-Absorption Curcumin for the Prevention of Hypertensive Heart
Disease: A Double-blind, Placebo-controlled, Randomised Clinical Study
European Heart Journal Open Aug 2022
Cardiovascular Risk Factors and Clinical Outcomes among Patients
Hospitalized with COVID-19: Findings from the World Heart Federation COVID19 Study
Global Heart 17(1) June 2022
DOI: 10.5334/gh.1128
IF: 3.426

Long-Term Effect of Febuxostat on Endothelial Function in Patients With
Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study
Frontiers in Cardiovascular Medicine 9:882821 April 2022
DOI: 10.3389/fcvm.2022.882821
IF: 6.050
Association between serum urate level and carotid atherosclerosis: An insightfrom a post hoc analysis of the PRIZE randomised clinical trial
RMD Open 8(1):e002226 April 2022
DOI: 10.1136/rmdopen-2022-002226
IF: 5.117
Differential effect of a xanthine oxidase inhibitor on arterial stiffness and carotid
atherosclerosis: a subanalysis of the PRIZE study
Hypertension Research 45(4) February 2022
DOI: 10.1038/s41440-022-00857-9
IF:3.872
Topiroxostat versus allopurinol in patients with chronic heart failure complicatedby hyperuricemia: A prospective, randomized, open-label, blinded-end-point
clinical trial
PLoS ONE 17(1):e0261445 January 2022
DOI: 10.1371/journal.pone.0261445
IF: 3.730
Soluble Vascular Endothelial Growth Factor Receptor 2 and Prognosis inPatients with Chronic Heart Failure
Eur Soc Cardiol Heart Fail. 2022 (e-pub ahead of print)
IF: 4.411
Impact of Chronic Kidney Disease on the Associations of Cardiovascular
Biomarkers With Adverse Outcomes in Patients With Suspected or Known
Coronary Artery Disease: The EXCEED‐J Study
J Am Heart Assoc. 11(3) January 2022
DOI: 10.1161/JAHA.121.023464
IF: 4.660

Usefulness of dual􀌻axis rotational coronary angiography in primarypercutaneous coronary intervention for patients with ST􀌻elevation
myocardial infarction
Heart and Vessels 2021 DOI 10.1007/s00380-020-01738-2 ISSN 0910-8327
PMID: 33277662
IF: 1.618
Which is the best method in clinical practice for assessing improvement in
vascular endothelial function after successful smoking cessation - Flowmediated dilation (FMD) or reactive hyperemic peripheral arterial tonometry(RHPAT)?
Hypertens Res 2021 Jan;44(1):120-121. doi: 10.1038/s41440-020-005652. Epub 2020 Oct 22.
IF: 2.941
Impact of Smoking Status on Growth Differentiation Factor 15 and Mortality inPatients With Suspected or Known Coronary Artery Disease: The ANOX Study
J Am Heart Assoc. 2020 Nov 10:e018217. doi: 10.1161/JAHA.120.018217.
Online ahead of print.PMID: 33170061
IF: 4.660
Febuxostat does not delay progression of carotid atherosclerosis in patientswith asymptomatic hyperuricemia: A randomized, controlled trial
PLoS Med. e1003095. Published online 2020 Apr 22. doi:
10.1371/journal.pmed.1003095
IF: 11.048
Distinct Characteristics of VEGF-D and VEGF-C to Predict Mortality in Patients
With Suspected or Known Coronary Artery Disease.
J Am Heart Assoc.
2020;9:e015761. DOI: 10.1161/JAHA.119.015761
IF: 4.660

Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles.
Drug Metabolism and Pharmacokinetics. 2020 Feb;35(1):151-159. doi:
10.1016/j.dmpk.2019.10.005.
IF: 1.874
VEGF-C and Mortality in Patients With Suspected or Known Coronary
Artery Disease.
J Am Heart Assoc. 2018 Nov 6;7(21):e010355
IF: 4.660
The effects of xanthine oxidase inhibitor in patients with chronic heart
failure complicated with hyperuricemia: a prospective randomized
controlled clinical trial of topiroxostat vs allopurinol-study protocol.
Clin Exp Nephrol. 2018 Dec;22(6):1379-1386.
IF:1.971
Kampo extract goshuyuto as an option for preventive treatment ofparoxysmal atrial fibrillation associated with migraine attacks.
Traditional and Kampo Medicine 2018; 5(2): 120-122.
Choice of Antihypertensive Combination Therapy Based on Daily Salt
Intake.
Am J Med Sci. 2015 Sep;350(3):160-6.
IF:1.962
Docosahexaenoic Acid with a statin and endothelial function in patientswith coronary artery disease.
J Atheroscler Thromb. 2015;22(5):440-1.
IF:3.478
Two-week administration of rivaroxaban resolved left atrial thrombus.
J Cardiol Cases. J Cardiol Cases. 2014 Sep 26;10(6):238-240. doi: 10.1016/j.jccase.2014.08.006.

Therapeutic potential of α-glucosidase inhibitors to prevent postprandial
endothelial dysfunction.
Int Heart J. 2014;55(5):386-90.
IF:2.226
Varenicline-assisted smoking cessation decreases oxidative stress andrestores endothelial function.
Hypertens Res. 2014 Jul;37(7):655-8.
IF:3.872