研究業績(2012.4.1-2013.3.31)
英文原著
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Abe Y, Ijichi N, Ikeda K, Kayano H, Horie-Inoue K, Takeda S, Inoue S. Forkhead
box transcription factor, forkhead box A1, shows negative association with lymph
node status in endometrial cancer, and represses cell proliferation and migration ofendometrial cancer cells. Cancer Sci 103, 806-812, 2012.
Araki A, Iimuro S, Ohashi Y, Iijima K, Sakurai T, Umegaki H, Ito H, J-EDIT
Investigator Group. Non-high-density lipoprotein cholesterol: an important
predictor of stroke and diabetes-related mortality in Japanese elderly diabeticpatients. Geriatr Gerontol Int 12 Suppl 1, 18-28, 2012.
Araki A, Iimuro S, Ohashi Y, Iijima K, Sakurai T, Umegaki H, Ito H, J-EDIT
Investigator Group. Long-term multiple risk factor intervention in Japanese elderly
diabetic patients: The Japanese Elderly Diabetes Intervention Trial (J-EDIT)-study
design, baseline characteristics, and effects of intervention. Geriatr Gerontol Int
Suppl 1, 7-17, 2012.
Fujimura T, Takahashi S, Urano T, Tanaka T, Zhang W, Azuma K, Takayama K,Obinata D, Murata T, Horie-Inoue K, Kodama T, Ouchi Y, Homma Y, Inoue S.
Clinical significance of steroid and xenobiotic receptor and its targeted gene
CYP3A4 in human prostate cancer. Cancer Sci 103, 176-180, 2012.
Hibi S, Yamaguchi Y, Umeda-Kameyama Y, Yamamoto H, Iijima K, Momose T,Akishita M, Ouchi Y. The high frequency of periodic limb movements in patientswith Lewy body dementia. J Psychiatr Res 46, 1590-1594, 2012.
Hiroi H, Momoeda M, Watanabe T, Ito M, Ikeda K, Tsutsumi R, Hosokawa Y,Koizumi M, Nakazawa F, Osuga Y, Muramatsu M, Taketani Y, Inoue S. Expressionand regulation of transient receptor potential cation channel, subfamily M, member
2 (TRPM2) in human endometrium. Mol Cell Endocrinol 365, 146-152, 2013.
Iijima K, Iimuro S, Ohashi Y, Sakurai T, Umegaki H, Araki A, Yoshimura Y,Ouchi Y, Ito H, J-EDIT Investigator Group. Lower Physical Activity, but not
Excessive Calorie Intake, is Associated with Metabolic Syndrome in Elderly withType 2 Diabetes Mellitus: Japanese Elderly Diabetes Intervention Trial (J-EDIT).
Geriatr Gerontol Int 12, Suppl 1, 68-76, 2012.
Iijima K, Iimuro S, Shinozaki T, Ohashi Y, Sakurai T, Umegaki H, Araki A, Ouchi
Y, Ito H, J-EDIT Investigator Group. Lower Physical Activity is a Strong Predictor
of Cardiovascular Events in Elderly Patients with Type 2 Diabetes Mellitus beyond
Traditional Risk Factors: Japanese Elderly Diabetes Intervention Trial (J-EDIT).
Geriatr Gerontol Int 12, Suppl 1, 77-87, 2012.
Ijichi N, Shigekawa T, Ikeda K, Horie-Inoue K, Shimizu C, Saji S, Aogi K, Tsuda H,Osaki A, Saeki T, Inoue S. Association of double-positive FOXA1 and FOXP1
immunoreactivities with favorable prognosis of tamoxifen-treated breast cancerpatients. Horm Cancer 3, 147-159, 2012.

10. Iimuro S, Ohashi Y, Iijima K, Sakurai T, Umegaki H, Araki A, Ito H, J-EDIT
Investigator Group. Dietary pattern and mortality in Japanese elderly patients withtype 2 diabetes mellitus –Does vegetable- and fish-rich diet improve mortality ?:An explanatory study. Geriatr Gerontol Int 12 Suppl 1, 59-67, 2012.
11. Ikeda K, Tsukui T, Tanaka D, Maruyama Y, Horie-Inoue K, Inoue S. Conditional
expression of human bone Gla protein in osteoblasts causes skeletal abnormality inmice. Biochem Biophys Res Commun 424, 164-169, 2012.
12. Ikeda K, Tsukui T, Imazawa Y, Horie-Inoue K, Inoue S. Conditional expression of
constitutively active estrogen receptor α in chondrocytes impairs longitudinal bone
growth in mice. Biochem Biophys Res Commun 425, 912-917, 2012.
13. Ishii S, Cauley JA, Greendale GA, Danielson ME, Safaei Nili N, Karlamangla A.
Ethnic differences in composite indices of femoral neck strength. Osteoporos Int 23,1381-1390, 2012.
14. Ishii S, Grenndale G, Cauley JA, Crandall CJ, Huang MH, Danielson ME,Karlamangla A. Fracture Risk Assessment Without Race/Ethnicity Information. J
Clin Endocrinol Metab 97, 3593-3602, 2012.
15. Ishii S, Karlamangla AS, Bote M, Irwin MR, Jacobs DR, Cho HJ, Seeman TE.
Gender, Obesity and Repeated Elevation of C-Reactive Protein: data from theCARDIA cohort. PLoS ONE 7, e36062, 2012.
16. Ito M, Urano T, Hiroi H, Momoeda M, Saito M, Hosokawa Y, Tsutsumi R, Zenri F,Koizumi M, Nakae H, Horie-Inoue K, Fujii T, Yano T, Kozuma S, Inoue S,Taketani Y. The progesterone-responsive gene 14-3-3τ enhances the transcriptional
activity of progesterone receptor in uterine cells. J Mol Endocrinol 49, 193-202,
2012.
17. Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, Eto M, Ouchi
Y. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr
Gerontol Int 12, 425-30, 2012.
18. Murata T, Takayama K, Urano T, Fujimura T, Ashikari D, Obinata D, Horie-InoueK, Takahashi S, Ouchi Y, Homma Y, Inoue S. 14-3-3ζ, a novel
androgen-responsivegene, is upregulated in prostate cancer and promotes prostatecancer cell proliferation and survival. Clin Cancer Res 18, 5617-5627, 2012.
19. Obinata D, Takayama KI, Urano T, Murata T, Ikeda K, Horie-Inoue K, Ouchi Y,Takahashi S, Inoue S. ARFGAP3, an androgen target gene, promotes prostatecancer cell proliferation and migration. Int J Cancer 130(10):2240-2248, 2012.
20. Ogita M, Utsunomiya H, Akishita M, Arai H. Indications and practice for tube
feeding in Japanese geriatricians: Implications of multidisciplinary team approach.
Geriatr Gerontol Int 12, 643-651, 2012.
21. Takahashi T, Matsumoto S, Iijima K, Morimoto S. Guidelines for Nonmedical Care
Providers to Manage the First Step of Emergency Triage of Elderly Evacuees:Downloaded via Smart Phones in Japan. J Experimental and Clinical Medicine 59,2189-2191, 2012.
22. Takayama K, Horie-Inoue K, Suzuki T, Urano T, Ikeda K, Fujimura T, Takahashi S,Homma Y, Ouchi Y, Inoue S. TACC2 is an androgen-responsive cell cycleregulator promoting androgen-mediated and castration-resistant growth of prostatecancer. Mol Endocrinol 26, 748-761, 2012.
23. Umegaki H, Iimuro S, Ohashi Y, Iijima K, Sakurai T, Araki A, Ito H, J-EDIT
Investigator Group. Risk factors associated with cognitive decline in the elderlywith type 2 diabetes: Pooled logistic analysis of a 6-year observation in theJapanese Elderly Diabetes Intervention Trial (J-EDIT). Geriatr Gerontol Int 12Suppl 1, 110-116, 2012.
24. Umegaki H, Iimuro S, Ohashi Y, Iijima K, Sakurai T, Araki A, Ito H, J-EDIT
Investigator Group. Risk factors associated with cognitive decline in the elderlywith type 2 diabetes: Baseline data analysis of Japanese Elderly Diabetes
Intervention Trial (J-EDIT). Geriatr Gerontol Int 12 Suppl 1, 103-109, 2012.
25. Urano T, Shiraki M, Ouchi Y, Inoue S. Association of circulating sclerostin levels
with fat mass and metabolic disease--related markers in Japanese postmenopausal
women. J Clin Endocrinol Metab 97, E1473-1477, 2012.
26. Yu J, Akishita M, Eto M, Koizumi H, Hashimoto R, Ogawa S, Tanaka K, Ouchi Y,Okabe T. Src kinase-mediates androgen receptor-dependent non-genomic activationof signaling cascade leading to endothelial nitric oxide synthase. Biochem Biophys
Res Commun 424, 538-543, 2012.
英文短報
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Ga H, Kojima T: Purple urine bag syndrome. JAMA 307, 1912-1913, 2012.
Ishii M, Yamaguchi Y, Yamamoto H, Ouchi Y, Osumi S, Nakamura T: Relationship
Between Sleep Apnea and Respiratory Infections in BedRidden Elderly Individuals
on Tube Feeding. J Am Geriatr Soc 60, 790-792, 2012.
Kojima T, Akishita M, Kameyama Y, Yamaguchi K, Yamamoto H, Eto M, Ouchi
Y: High risk of adverse drug reactions in elderly patients taking six or more drugs:
analysis of inpatient database. Geriatr Gerontol Int 12, 761-762, 2012.
Kojima T, Akishita M, Kameyama Y, Yamaguchi K, Yamamoto H, Eto M, Ouchi
Y: Factors associated with prolonged hospital stay in a geriatric ward of auniversity hospital in Japan. J Am Geriatr Soc 60, 1190-1191, 2012.
Nagai K, Akishita M, Shibata S, Kobayashi Y, Yamada Y, Kimura S, Machida A,
Toba K, Kozaki K: Relationship between testosterone and cognitive function inelderly men with dementia. J Am Geriatr Soc 60, 1188-1189, 2012.
Toba K, Nagai K, Kimura S, Yamada Y, Machida A, Iwata A, Akishita M, Kozaki
K: New dorsiflexion measure device: A simple method to assess fall risks in theelderly. Geriatr Gerontol Int 12, 563-564, 2012.
Yamada Y, Eto M, Yamamoto H, Akishita M, Ouchi Y: Gastrointestinal hemorrhage
and antithrombotic drug use in geriatric patients. Geriatr Gerontol Int 12, 751-752,2012.
英文症例報告1.

Gotanda H, Kameyama Y, Yamaguchi Y, Ishii M, Hanaoka Y, Yamamoto H, Ogawa

S, Iijima K, Akishita M, Ouchi Y. Acute exogenous lipoid pneumonia caused byaccidental kerosene ingestion in an elderly patient with dementia: A case report.
Geriatr Gerontol Int 13, 222-225, 2013.
2. Ishii M, Yamaguchi Y, Yakabe M, Ohike Y, Eto M, Izutsu K, Hangaishi A,Akishita M, Kurokawa M, Ouchi Y. Intravascular large B-cell lymphoma withsymptoms resembling progressive dementia: a clinical case report. J Am Geriatr
Soc 61, 303-304, 2013.
3. Yonenaga A, Ota H, Honda M, Koshiyama D, Yagi T, Hanaoka Y, Yamamoto H,
Yamaguchi Y, Iijima K, Akishita M, Ouchi Y. Marked improvement of elderly
postprandial hypotension by dipeptidyl peptidase IV inhibitor. Geriatr Gerontol Int
13, 227-229, 2013.
英文総説
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Akishita M, Yu J. Hormonal effects on blood vessels. Hypertens Res 35, 363-369,
2012.
2. Azuma K, Inoue S. Genomic and non-genomic actions of estrogen: Recentdevelopments. BioMol Concepts 3, 365-370, 2012.
3. Migita T, Inoue S. Implications of the Golgi apparatus in prostate cancer. Int J
Biochem Cell Biol 44, 1872-1876, 2012.
4. Yamaguchi Y, Ouchi Y. Antimicrobial peptide defensin: identification of novel
isoforms and the characterization of their physiological roles and their significancein the pathogenesis of diseases. Proc Jpn Acad Ser B Phys Biol Sci 88, 152-166,
2012.