2023

拠点長挨拶

大阪大学は、感染症の脅威から人々の「いのちと暮らし」を守ることを目指し、2021年4月に、大阪大学感染症総合教育研究拠点（ Center for Infectious Disease Education and Research,
CiDER ）を設置しました。本拠点は、文系理系の枠を超えて大阪大学の叡智を集結し、国内外の研究機関や産業界と連携しながら、感Annual Report染症・生体防御研究部門、人材育成部門、科学情報・公共政策部門の3部門が連携し、新興・再興感染症の克服を目指しています。

また、日本財団の理解とご支援を賜り、人類の脅威である感染症の基礎研究・基盤研究の重要性のもとに、10年間の「日本財団・
大阪大学感染症対策プロジェクト」として推進しています。
CiDER は、このプロジェクトの推進役（ 母体 ）となる組織で、西尾総長のリーダーシップのもと、国内外の感染症研究と人材育成をリードする拠点としてプロジェクトに取り組んでいます。
2023年度は、本拠点の Vision「感染症の脅威から「いのちと暮らし」を守るための総合知を形成する」と、Mission「感染症総合知のハブとなる」に沿い、分野の垣根を越えて研究者が一体となってプロジェクトを推進してまいりました。今後のパンデミックが想定される様々な感染症に向き合うための基礎研究を中心に捉えるとともに、社会・経済活動の維持に貢献することを目指した人材の育成、社会への情報発信及び研究成果の社会実装を、学内外の様々な機関と連携しながら進めています。
2024年4月１日から、山﨑 晶教授が拠点長に着任いたします。
2024年度以降も、これまでの活動経験や成果などを活かしつつ展
開し、世界的な研究拠点の形成に向けて邁進いたします。
大阪大学感染症総合教育研究拠点
拠点長

Message from the Director

C ON T EN T S
1Message from Director

2

Vision and Mission
Organization

4

Research Activity▪ Division of Microbiology and
Immunology
Human Single Cell Immunology Team16

Regulation of Host Defense Team

Highly lethal infectious diseases have arisen countless times to date,

Virus Control Teambut people came to believe that such diseases could be eradicatedClinical Biotechnology Teamby the end of the 20th century through the development of vaccines

All Osaka University Research Project

and therapeutic drugs. The novel coronavirus pandemic that began▪ Division of Fostering Required

Medical Human Resources
Specimen Analysis Team
Infection Control Team
Medical Informatics Team24

▪ Division of Scientific Information andPublic Policy

34

Humankind has battled infectious diseases throughout its history.

in 2019, however, has exposed contemporary society’s continued
vulnerability to infectious diseases. Conquering the emergent and reemergent infectious diseases that will threaten society from now on
is a common challenge for the whole of humankind.
With the aim of protecting“our life and activity”from the threatof infectious diseases, Osaka University established the Center for
Infectious Disease Education and Research (CiDER) in April 2021.
The Center brings together Osaka University’s capabilities acrossBehavioral Economics Unit

the disciplinary borders of humanities, social sciences, and natural

Human Science Unitsciences, partnering with research institutes and industry players

Mathematical Analysis Unit

within Japan and internationally as it seeks to conquer emerging

ELSI & Technology Unit

and re-emerging infectious diseases through collaboration acrossInformation
・Publications
・Preprint

three divisions: the Division of Scientific Information and Public
Policy, the Division of Microbiology and Immunology, and theDivision of Fostering Required Medical Human Resources.
As a center for comprehensive research and education, CiDER
is committed to playing a leading role in infectious disease researchand human resource development in Japan and internationally. All
members of CiDER will work together to discharge our mission ofprotecting“our life and activity”from the threat of infectious diseases,
and to enable the center to function as a hub that is open to the world.
We appreciate your continued encouragement and support.

Director,
Center for Infectious Disease Education and Research▎

Organization

Supervisor▎

CiDER pursues infectious disease-related research, education andtraining, information-sharing, and practical application of researchﬁndings in wider society, with the aim of preparing for threats

Yasufumi KANEDA

posed by infectious diseases in future and protecting Our life andSenior Executive Vice President

activity" as well as contributing to the maintenance of social andeconomic activity.

Organization

Director
Yoshiharu MATSUURA
Specially Appointed Prof.

DeputyDirector

Fumio OHTAKE

Akira KIKUCHI

Specially Appointed Prof.

Specially Appointed Prof.

Management
Director

VisionConvergence ofknowledge : to protect“ life and activity ”
from infectious diseases

MissionTo become a hub for
infectious diseaseeducation and research

Division of Microbiology and
Immunology

Division of Fostering Required
Medical Human Resources

Division of ScientiﬁcInformation and Public Policy

Promotion of comprehensive
research and development on
infectious disease prevention,
diagnosis, and treatment

Cultivation of leaders in
infectious disease control andsupprt for health-care workers
to acqire the latest skills related
to infectious diseases

Provision of comprehensive(scientiﬁc evidence-based)
information on infectious
diseases to society

Divisional
Director

Deputy Divisional
Director

Kiyoshi TAKEDA

Eiichi MORII

Takashi NAKANO

Prof.
Graduate School of
Medicine

Prof.
Graduate School of
MedicineProf.
Research Center for
Nuclear Physics

Divisional
Director

Divisional
Director

Noboyuki TAKAKURA

Satoshi KUTSUNA

Asako MIURA

Prof.
Research Institute forMicrobial Diseases

Prof.
Graduate School of
Medicine

Prof.
Graduate School of
Human Sciences

Deputy Divisional
Director

Deputy Divisional
Director

Atsuo KISHIMOTO

Deputy Divisional
Director

Human Single Cell Immunology Team

2

Prof.
Institute for Datability
Science

Behavioral Economics Unit

Regulation of Host Defense TeamSpecimen Analysis Team

Human Science Unit

Virus Control Team

Infection Control Team

Mathematical Analysis Unit

Clinical Biotechnology Team

Medical Informatics TeamELSI & Technology Unit

3

Research Activity

Human Single Cell Immunology Team
Regulation of Host Defense Team
Virus Control Team

Division of Microbiology and Immunology

Division of Microbiology
and Immunology
Divisional DirectorProf.

Kiyoshi TAKEDA

Clinical Biotechnology TeamFor the prevention, diagnosis, and treatment of infectious diseases, it
is essential to elucidate the characteristics of pathogenic microorganisms
and the host defense system against pathogens. In this division, we
promote basic research aimed at fundamentally overcoming infectious
diseases. In particular, we aim to elucidate not only the characteristics
of pathogenic microorganisms, but also human host defense systems andimmune response mechanisms against pathogenic microorganisms. To
this end, we will promote comprehensive basic research and development
across disciplines by bringing together microbiology researchers,
immunology researchers, and clinical medicine researchers.

4

5

Division of Microbiology
and Immunology

Overview

Human Single Cell Immunology TeamWe focus on the use of single cell biology techniques such as mass cytometry to
decode the complexity of the immune system. We apply this approach to various

Focus on the details,
that's where we ﬁnd the truth.

▍Summary of Results for FY2023
Research Activity

settings such as infectious diseases and autoimmunity with a particular focus on
the regulation of antibody responses.

・Result１：During infection and vaccination antigen speciﬁc B-cells
are the producers of antibodies and critical to protection. However,
our understanding of which types of B-cells are important isincomplete. It is generally believed that classical memory B-cells
are the most important cells responding to vaccines and infections,but this has been limited by technical limitations of either thedepth of analysis or the ability to look at large numbers of samples
over time. We have developed new methods that overcome theselimitations and use them to allow analysis of both resting memory

Division of Microbiology and Immunology

phases long after vaccination and the acute phase immediately
during infection or immediately after vaccination.
Here by multimodal analysis of large cohorts of COVID-19 andmRNA vaccine recipients we have found that several forms of nonclassical memory were the majority of SARS-CoV2 speciﬁc B-cells
at different moments in time. In the acute phase we discovered
a novel subset that we have termed Activated atypical B-cells
which are the majority of SARS-CoV2 specific B-cells during inboth COVID-19 infection and mRNA vaccination. In contrast, during

Figure 1: Total and SARS-CoV2 specific B-cells
following vaccination or SARS-CoV2 infection(COVID-19). While classical memory B-cells are
the majority of B-cell memory we find that nonclassical and atypical B-cells dominate the SARSCoV2 response.

the resting phase, we found a separate group of CD23+IL4R+ nonclassical B-cells contained the majority of SARS-CoV2 specificmemory (Figure 1).

Team Leader
Assoc. Prof.

James Badger WING
I am originally from the UK, and, as part of my early career
training in infectious diseases, I became interested inSince this is the first description of a role for both Activatedatypical memory and CD23+IL4R+ memory cells in vaccinationand infection this is a major ﬁnding that changes our understandingof what types of cells respond to mRNA vaccination and may provecritical to the development of more effective vaccinations in the
future.

how the immune system regulates antibody responses.

Members

Antibodies are critical to the ﬁght against infection but can

Non-classical CD45RBlo memory B-cells are the majority ofalso cause autoimmunity. 12 years ago, I moved to Japan

circulating antigen-specific B-cells following mRNA vaccination

join the laboratory of Shimon Sakaguchi, who discovered

and COVID-19 infection. Research Square (Preprint currently underregulatory T-cells, which are the cells most critical toSpecially Appointed Assis. Prof.

Jonas Nørskov SØNDERGAARD
Specially Appointed Researcher

Janyerkye TULYEUSpecially Appointed Technical Staﬀ

the control of the immune system. With his kind guidance
I was able to focus on a new type of Treg, T-follicularregulatory cell, that controls antibody responses. This cellis important to control both vaccine responses and viral

Rika ISHII

infections. More recently I was lucky enough to be able

Specially Appointed Technical Staﬀ

to open a new laboratory that focuses on the use of mass

Asami KATSUSHIMA

cytometry, a technology that allows us to investigate theVisiting Scientist

biology of millions of immune cells in detail. I would like toLaura BARBIERI

humbly thank everyone for their kind support and using

review), 2024 https://doi.org/10.21203/rs.3.rs-3618616/v1
DG Priest, T Ebihara, J Tulyeu, J Søndergaard, S Sakakibara,
F Sugihara, S Nakao, Y Togami, J Yoshimura, H Ito, S Onishi, A
Muratsu, Y Mitsuyama, H Ogura, J Oda, D Okuzaki, H Matsumoto,
JB. Wing.

these new technologies I hope to contribute to the fight6

against infectious diseases.

7

Division of Microbiology
and Immunology

Overview

Regulation of Host Defense TeamAs we've learned during COVID-19 pandemic, establishing virus-specific immune
memory is essential for protection from viral infection and is the goal of current

We study how immune cells ﬁght against
respiratory virus and develop memory for
future infection.
▍Summary of Results for FY2023

neutralizing antibodies mater for long-term protection from mutant viruses. We
study the mechanisms underlying development of long-lasting antibody response,
particularly focusing on follicular helper T cells in germinal centers, and long-lived

Research Activity

vaccines. Specificity and durability of memory T cells, memory B cells, andIdentiﬁcation of a critical factor for long-term antibody response
Antibodies are soluble eﬀector proteins produced by terminally diﬀerentiated B cells, called plasma cells. A small
fraction of plasma cells generated upon infection or vaccination survive for months or years in bone marrow, continue

plasma cells. We also study how immune system promotes repair of the damaged

to produce neutralizing antibodies, and contribute to long-term protection. However, the molecular mechanisms

tissues during respiratory viral infection, especially by looking at interaction between

underlying migration of plasma cells from lymphoid tissues to bone marrow have been unclear. We have foundimmune cells and lung epithelial cells. Our research will lead to the development ofthat integrin β7hi plasma cells in lymphoid tissues selectively egress to blood and migrate to bone marrow upon

new vaccine strategies or therapeutic drugs.

vaccination or infection. Induction of integrin β7hi plasma cells and their egress to blood depends on the transcription
factor KLF2 (Fig. A). Disruption of plasma cell egress by Klf2 deficiency results in defect in maintaining antigenspeciﬁc antibody response (Fig. B) and in protection from viral infection (Fig. C). Thus, our results suggest that the fate
Division of Microbiology and Immunologyof plasma cells is determined by the expression levels of KLF2 within the induction site and that induction of KLF2 inplasma cells is essential for durable antibody response.

Team Leader
Prof.

Wataru ISE
I graduated from University of Tokyo and from graduate
school of Agricultural and Life Sciences, University ofTokyo with a PhD in Agriculture, and joined the faculty

Members

there as an assistant professor. After a postdoctoral fellow

1) Koike T, Fujii K, Kometani K, Butler NS, Funakoshi K, Yari S, Kikuta J, Ishii M, Kurosaki T, Ise W. Progressive
diﬀerentiation toward the long-lived plasma cell compartment in the bone marrow. J Exp Med. 2023 Feb 6; 220(2):e20221717. doi: 10.1084/jem.20221717.

in Howard Hughes Medical Institute, Washington University
Assoc. Prof.

Masako KOHYAMA
Specially Appointed Assis. Prof.

Daiki MORIJSPS Research Fellowship for Young Scientists (PD)Takuya KOIKE
8

in St. Louis, I joined IFReC, Osaka University, as a specially

2) Ise W, Kurosaki T. Tissues of origin matter to plasma cell longevity. Nat Immunol. 2024 Feb; 25(2): 194-195. doi: 10.1038/

appointed Associate Professor, in 2011. Since 2021, I

s41590-023-01731-7.

have been a professor and a team leader of regulationof host defense team in Division of Microbiology and
Immunology, CiDER, Osaka University.

9Division of Microbiology
and Immunology

Virus Control Team

Living with viruses▍Summary of Results for FY2023

Overview

Recent COVID-19 pandemic has taught us how humans are vulnerable to unknown
emerging viral diseases. It is difficult to predict the pandemic of emerging and re-understanding of the viral pathogenesis by clarifying virus-host interactions and tobuild a system that can prepare therapeutic and preventive methods ahead of time.

Research Activity

emerging infectious diseases. Our research aims to develop a comprehensive

1. High-Puriﬁed Slightly Acidic Hypochlorous Acid Water Exhibits Potent
Disinfectant Eﬀects Against Various Viruses
Virus Control Team, in a joint study with the Research Institute for Microbial Diseases at Osaka University, National Institute of Infectious
Diseases, and Louis Pasteur Center for Medical Research has discovered that slightly acidic hypochlorous acid water (Hp-SA-HAW) exhibits
strong antiviral activity against various viruses by causing irreversible protein aggregation, thereby attenuating the viruses' infectivity.

This study has clariﬁed that Hp-SA-HAW is eﬀective against various viruses, including adenovirus, hepatitis B, Japanese encephalitis virus,
rotavirus, and SARS-CoV-2. While posing a low risk to human tissues and surfaces, Hp-SA-HAW reduces viral infectivity by causing irreversible
viral protein aggregation. This indicates its potential as an eﬀective disinfectant for preventing the spread of viruses transmitted through air ordroplets, serving as a crucial tool for pandemic control measures.

The research ﬁndings were published in “Frontiers in Microbiology” on October 19, 2023.
Title:『Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation』
Authors: Rahmi Dianty, Junki Hirano, Itsuki Anzai, Yuta Kanai, Tsuyoshi Hayashi, Masae Morimoto, Chikako Kataoka-Nakamura, Sakura
Kobayashi, Kentaro Uemura, Chikako Ono, Tokiko Watanabe, Takeshi Kobayashi, Kosuke Murakami, Kenji Kikuchi, Kunimoto Hotta,

Division of Microbiology and Immunology

Toshikazu Yoshikawa, Shuhei Taguwa, Yoshiharu Matsuura

Team Leader
Specially Appointed Prof.

2. Development of novel neutralizing antibodies against SARS-CoV-2 andelucidation of their mechanism of action

Yoshiharu MATSUURAIn the Virus Control Team, through joint research with the Research Institute for Microbial Diseases at Osaka University, the Faculty of

Dr. Matsuura received his PhD in Veterinary Medicine

antibody against the S protein of SARS-CoV-2 was developed, and it was revealed that it exhibits a unique mechanism of action.

Pharmaceutical Sciences at Osaka University, JEOL Ltd., the BIKEN Foundation, Biomatrix Research Inc., and the RIKEN, a new neutralizing

from Hokkaido University. He worked at Daiichi Seiyaku

Members

Co. Ltd and National Institute for Infectious Diseases inThis study suggests that antibody CSW1-1805 exhibits a unique mechanism of action by recognizing the S protein's protruding part of the RBDTokyo. Then he went on to work as a postdoctoral fellow

and inducing structural changes, thereby more reliably inhibiting binding with ACE2. The insights gained from this characteristic evaluation are

Specially Appointed Assoc. Prof.

at the NERC Institute of Virology in Oxford University.

Chikako ONO

He joined the Research Institute for Microbial Diseases

Specially Appointed Assoc. Prof.

Shuhei TAGUWA
Specially Appointed Assis. Prof.

Kentaro UEMURA
Specially Appointed Assis. Prof.

(RIMD) in Osaka University in 2000 as Professor andserved as Director of RIMD from 2015 to 2019. He has
been appointed Director of Center for Infectious Diseases
Education and Research in 2021.

expected to form the molecular basis for developing new antibody drugs.

The research ﬁndings will be published in “ Microbiology Spectrum ” (in press)
Title：『Characterization of a neutralizing antibody that recognizes a loop region adjacent to the receptor-binding interface of the SARS-CoV-2
spike receptor-binding domain』
Authors：Itsuki Anzai, Junso Fujita, Chikako Ono, Yoichiro Kosaka, Yuki Miyamoto, Shintaro Shichinohe, Kosuke Takada, Shiho Torii, Shuhei
Taguwa, Koichiro Suzuki, Fumiaki Makino, Tadahiro Kajita, Tsuyoshi Inoue, Keiichi Namba, Tokiko Watanabe, Yoshiharu Matsuura

Kazuma OKADA
10

11

Division of Microbiology
and Immunology

Overview

Clinical Biotechnology Team

mRNA is a new drug modality that was ﬁrst commercialized as a novel coronavirus
vaccine. It can be produced by any protein, regardless of the target cell, and ismRNA vaccine and drug development ﬁnallyin full swing▍Summary of Results for FY2023

diseases, personalized vaccines applied to cancer immunotherapy, and disease
prevention and treatment by directly controlling the function of cells in vivo. Ourlaboratory will pursue mRNA drug discovery that contributes to improving peopleʼs

Research Activity

expected to be used for rapid vaccine development against emerging infectious
In pursuit of mRNAʼs potential as a drug modality, we are developing a new mRNA design and DDS, and applying themRNAs to vaccines and disease therapies. In 2023, we developed a novel system to control protein translation fromadministered mRNAs depending on the presence of target molecules in the cell (paper submitted). In addition, we
achieved excellent bone regeneration using mRNA medicines (Inﬂammation and Regeneration 43:32, 2023). We also

quality of life by setting a wide range of themes from functional mRNA design, DDS

conducted a comprehensive analysis on the polyplex nanomicelles in comparison with lipid nanoparticles (LNPs),

development, and analysis of drug eﬃcacy mechanisms.

which are mainly used in mRNA vaccines, by delivering the mRNAs to skeletal muscle under the same conditions,demonstrating their typical properties (Pharmaceutics 15(9): 2291, 2023). Various applications of mRNA medicine are
now under consideration, including the project of mRNA medicine for treating osteoarthritis, which is scheduled tostart the ﬁrst clinical trial of an mRNA medicine in Japan.

Division of Microbiology and Immunology

Team LeaderProf.

Keiji ITAKA
After graduating from the University of Tokyo Facultyof Medicine in March 1991, he worked as an orthopedic
surgeon at Mitsui Memorial Hospital and other hospitals.
After working as an assistant professor at The Universityof Tokyo Hospital in 1997, he entered Graduate School ofMembers

Medicine of The University of Tokyo in 1999, where heSpecially Appointed Researcher

of Engineering. After Ph.D. acquisition in 2003, he worked

Yooksil SIN

began research on DDS in collaboration with Department
on DDS, gene therapy, and nucleic acid medicine (mRNA
medicine) development as lecturer and associated professor
at The University of Tokyo. In April 2017, he became aprofessor at Institute of Biomaterials and Bioengineering,Tokyo Medical and Dental University. In August 2022, healso became a professor at Center for Infectious Diseases

12

Education and Research (CiDER), Osaka University.

13

Cross-Departmental Infectious Diseases”
Research Promotion Program − All Osaka University Research Project −The “Team Osaka University Project” was launched in July 2020 to promote research andOutlinedevelopment on coronavirus disease 2019 (COVID-19) across specialties and departments on
Osaka University. In April 2022, Cross-Departmental “Infectious Diseases” Research Promotion
Program was started to promote interdisciplinary research which was expected to establish new

03

Enhancement of IL-6 Production Induced by SARS-CoV-2 Nucleocapsid
Protein and Bangladeshi COVID-19 Patients Sera

Coronavirus disease 2019 (COVID-19) is a respiratory tract infection causedby severe acute respiratory syndrome coronavirus 2 that can have detrimental
effects on multiple organs and accelerate patient mortality. This study, which

2023, we widely inviting research in the humanities and social sciences and 18 additional projects

encompassed 130 confirmed COVID-19 patients who were assessed at threewere adopted. From now on, we aim to achieve CiDERʼs vision of “To become a hub for infectious

diﬀerent time points after the onset of symptoms, investigated interleukin-6 (IL-6)

disease education and research”, further promoting fusion research with the natural sciences.

Research Activity

basic research ﬁelds through the whole university and 37 projects were adopted. Furthermore, inenhancement induced by a viral nucleocapsid (N) protein from a myeloid cell line.
To evaluate IL-6-inducing activity, heat-inactivated sera from these patients wereincubated with and without the N protein. The findings showed a progressive▍Summary of 2023

01

increase in IL-6 production in severe cases upon N protein stimulation. There
was a strong correlation between anti-N antibodies and levels of IL-6 secreted

Intranasal immunization with an RBD-hemagglutinin fusion protein
harnesses preexisting immunity to enhance antigen-speciﬁc responses

by myeloid cells in the presence of N protein and sera. Uncontrolled IL-6 production played a pivotal role in disease pathogenesis, exacerbating
both disease severity and mortality. Eﬃciently targeting the N protein could potentially be employed as a therapeutic strategy for regulating theimmune response and alleviating inﬂammation in severe cases.（ Hasan A, et al.

2023. DOI : 10.3390/v15102018）

Intranasal vaccines are anticipated to be powerful tools for combating manysystemic immunity but also mucosal immunity at the site of initial infection.
However, they are generally inefficient in inducing an antigen-specificimmune response without adjuvants. Here, we developed an adjuvant-free
intranasal vaccine platform that utilizes the preexisting immunity induced
by previous infection or vaccination to enhance vaccine effectiveness.
We made RBD-HA, a fusion of the receptor-binding domain (RBD) of spike
derived from SARS-CoV-2 as a vaccine target with HA derived from inﬂuenza
A virus (IAV) as a carrier protein. Intranasal immunization of previously IAVinfected mice with RBD-HA without an adjuvant elicited robust production of
RBD-speciﬁc systemic IgG and mucosal IgA by utilizing both HA-speciﬁc preexisting IgG and CD4+ T cells. Consequently, the mice wereeﬃciently protected from SARS-CoV-2 infection. Additionally, we demonstrated the high versatility of this intranasal vaccine platform byassessing various vaccine antigens and preexisting immunity associated with a variety of infectious diseases. The results of this study
suggest the promising potential of this intranasal vaccine platform to address problems associated with intranasal vaccines.
（ Kawai A, et al.

2023. DOI : https://doi.org/10.1172/JCI166827 ）04

PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid
Biosynthesis, Is a Potent Mincle Ligand

Although leprosy (Hansenʼs disease) is one of the oldest known diseases, thepathogenicity of(Single-cell analyses and host genetics highlight the role of innate immune
cells in COVID-19 severity

Mechanisms underpinning the dysfunctional immune response in severe acute) remains enigmatic. Indeed, thecell wall components responsible for the immune response againstareas yet largely unidentiﬁed. We reveal here phenolic glycolipid-III (PGL-III) as an-speciﬁc ligand for the immune receptor Mincle. The cocrystal structure of
Mincle and a synthetic PGL-III analogue revealed a unique recognition mode, implyingthat it can engage multiple Mincle molecules. In Mincle-deﬁcient mice infected with, increased bacterial burden with gross pathologies were observed. PGLIII, a potent immunostimulatory glycolipid, is limited inby the quick additionof a single methyl group to convert it into immunosuppressive PGL-I, which confer s
immune escape. These results show that PGL-III is a noncanonical ligand recognized by Mincle. Elucidating the regulatory mechanisms of thesecomponents may lead to an understanding of an immune-escaping strategy of（ Ishizuka S, et al.

02

All Osaka University Research Project

infectious diseases, including SARS-CoV-2, because they induce not only05

, which may provide further therapeutic options.

2023. DOI: https://doi.org/10.1021/acscentsci.3c00040）

Analysis of Differences in Characteristics of High-Risk Endemic Areas forContracting Japanese Spotted Fever, Tsutsugamushi Disease, and Severe
Fever With Thrombocytopenia Syndrome

respiratory syndrome coronavirus 2 infection are elusive. We analyzed singlecell transcriptomes and T and B cell receptors of 895,000 peripheral blood

Tick-borne infections, including tsutsugamushi disease, Japanese spotted fever, andmononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients andsevere fever with thrombocytopenia syndrome (SFTS), are prevalent in East Asia with75 healthy controls of Japanese ancestry with host genetic data. We found thatvarying geographic distribution and seasonality. We conducted an ecologic study in

CD14+CD16++ monocytes, a rare cell type among monocytes, are involved inJapan nad identified 4493 patients who were hospitalized for tick-borne infections.

COVID-19 severity. Further, COVID-19 severity-associated genes identified by

Mixed-eﬀects modiﬁed Poisson regression analysis revealed that environmental factors,

genome-wide association study (GWAS), such as IFNAR2, have speciﬁc function

such as temperature, sunlight duration, elevation, precipitation, and vegetation, weremainly in monocytes and dendritic cells. These findings are expected to lead

associated with the risk of contracting these diseases. Tsutsugamushi disease wasto the development of new therapeutic strategy for various infectious diseases

positively associated with higher temperatures, farms, and forests, whereas Japanese

including COVID-19.

spotted fever and SFTS were positively associated with higher solar radiation and（ Edahiro R, Shirai Y, et al.
s41588-023-01375-1）

2023. DOI : https://doi.org/10.1038/

forests. Our findings from this ecologic study indicate that different environmental
factors play a signiﬁcant role in the risk of transmission of tick-borne infections. Understanding the diﬀerences can aid in identifying high-riskareas and developing public health strategies for infection prevention. Further research is needed to address causal relationships.
（ Ogawa T, et al.

14

2024. DOI : 10.1093/oﬁd/ofae025 ）15

Research Activity

Specimen Analysis Team
Infection Control Team
Medical Informatics Team

Division of Fostering Required Medical Human Resources

Division of Fostering
Required Medical Human
Resources
Divisional Director
Prof.

Eiichi MORII

We educate medical professionals and those who will become medical
professionals on the latest technology and knowledge of infectious
disease control and testing, and cultivate future infectious disease
control leaders and researchers developing new testing technology. We
support healthcare workers to acquire the latest skills related to infectiondiseases. We will foster diverse human resources by preparing various
educational contents. We will promptly and flexibly respond to required
medical needs, and provide medical human resource education that isrequired at each time.

16

17

Division of Fostering Required
Medical Human Resources

Overview

Specimen Analysis TeamTechnologies such as sample collection and testing are advancing day by day, andnew medical equipment and medical technology are being introduced to the ﬁeld

Investigation, Fostering, Innovation▍Summary of Results for FY2023

build new sample collection methods, test methods, and sample analysis systems.

Research Activity

every day. Under these circumstances, we will develop human resources who can

Establishment of a specimen management system for infectious
diseases
In collaboration with the Department of Pathology, Osaka University Hospital, our team has been collecting clinicalspecimens related to infectious diseases and constructing a specimen management system. In 2023, we collected
and registered an additional 305 specimens related to infectious diseases. From this fiscal year, the specimen
analysis software <BIOPRISM> was introduced to verify the specimen management program in actual operation, andeﬀorts are being made to build a system that enables eﬃcient management of clinical specimens and linking them toDivision of Fostering Required Medical Human Resources

clinical information.

Creation of educational contents
The Human Resource Development Division is making a concerted eﬀort to create educational contents. Our Team
creates and edits videos for CORE-ID. We have also created one video by member of the team, and have built asystem that allows us to complete everything from content recording to editing, uploading, and analysis of viewing
status within our department.

Development of new pathogen detection systems
In collaboration with the Institute of Scientific and Industrial Research, our team has developed an innovativetechnology to electronically detect and identify individual pathogen particles. Using AI nanopores, we are also
attempting to identify both Gram-positive and Gram-negative bacteria, with the aim of detection in clinical specimens.
This fiscal year, we have developed a detection method for Gram-positive bacteria, such as

Team Leader
Endowed Chair Assoc. Prof.

and, and reported it in Scientific Reports. AI nanopores can quickly develop

new pathogen detection methods by learning diﬀerent pathogens through AI, enabling rapid response to emerging
infectious diseases in the future.

Shigeto HAMAGUCHI(Graduate School of Medicine)
Members

Graduated from Jichi Medical University. After engaging inEndowed Chair Assis. Prof.

remote medical care, I have been conducting clinical andYuichi MOTOYAMA

basic research on infectious diseases and infection control(Graduate School of Medicine)
Endowed Chair Assis. Prof.

Hiroki KIYOKAWA(Graduate School of Medicine)Specially Appointed Researcher

at Infection Control and Prevention Department in Osaka
University Hospital. My main research themes are themechanism of pneumonia and transmission mode causedby Streptococcus pneumoniae and drug-resistant bacteria,

Yuriko TANAKA

and the establishment of a novel pathogen detection(Graduate School of Medicine)system.

18

19

Division of Fostering Required
Medical Human Resources

Overview

Infection Control Team

There is a shortage of personnel specialized in infection control and infection

Rooted in the community,
contributing to the world▍Summary of Results for FY2023

prevention, and it is urgent to nurture future leaders in infection control measures.

knowledgeable about infection prevention. Our team aims to train physicians,
pharmacists, and allied health professionals who will contribute to infection control,
as well as to raise awareness about infectious diseases among the public.

Practice of Infectious Diseases Education

Research Activity

It is also important for not only healthcare workers but also citizens to be

Regardless of online/onsite settings, we provided education related to infectious diseases to various learners.

1) CiDER-Sponsored Events
With the goal of establishing a foundation for infectious disease treatment and training clinicians aspiring to become
infectious disease physicians, we hosted seminars like those listed below, oﬀering education to numerous participants.
Date

Name

Participants

2023.7.30

Training and networking for clinicians aspiring to
be infectious disease doctors in Kansai

60

2023.8.15-

The 12th Annual Tropical
Infectious Diseases Physician
Training at the Thai-Myanmar
Border

Providing clinical practice and public healtheducation on tropical infectious diseases to young
doctors aspiring to specialize in infectious diseases

152023.10.14

AMR Countermeasure ClinicalSeminar in Osaka

Reporting on Japanʼs AMR measures to date andsharing information on future initiatives and outlook

1832024.2.23

Career Planning Seminar for
Infectious Disease Physicians

Presenting career plans to doctors who aspire to
be infectious disease physicians

49

2024.3.10

Tick-Borne Infectious
Diseases Case Study Meeting

Consolidating knowledge about tick-borne infectious
diseases and improving the quality of clinicalpractice

187

Division of Fostering Required Medical Human Resources

PurposeOsaka Infectious Diseases
Summer Seminar 2023

2) Creation of Infectious Disease-Related Educational Content for Healthcare Workers
CiDER-EDU: We established CiDER-EDU as an educational content delivery platform for learning correctknowledge on infectious disease treatment. Our team provided 35 video lectures.
Kutsu Juku: We oﬀered two lectures providing knowledge for case reports related to infectious diseases.
Standalone Videos: We oﬀered nine lectures that could be attended without registering for CiDER-EDU.

Team Leader

Creation of Educational Content for the Public: Mainly using YouTube, we created content to provide infectious

Endowed Chair Assoc. Prof.

Kutsu-Oh Cider (https://www.cider.osaka-u.ac.jp/plus-cider/category/kutsu-king-cider/)Ryuichi Minoda SADA
(Graduate School of Medicine)disease-related information to the public.

3) Lectures Targeted at Students
We conducted 49 lectures related to infectious diseases for students of Osaka University.

Recently, the importance of appropriate use of antimicrobials

Members

has increased due to the rise of drug-resistant bacteria,

Endowed Chair Assoc. Prof.

growing. Additionally, during the COVID-19 pandemic, many

Shungo YAMAMOTO

medical institutions lacked infectious disease specialists(Graduate School of Medicine)and the demand for specialists in infectious diseases is4) Lectures Inside and Outside the Hospital
We made nine video lectures titled “Antimicrobial Seminar” for the interns at Osaka University Hospital, creating
an environment where they could be viewed at any time.

who should have been the leaders in hospital treatment,

Endowed Chair Assoc. Prof.
Go YAMAMOTO (Graduate School of Medicine)

making the training of infectious disease specialists an

We conducted 24 lectures titled Tenri Infectious Diseases Seminar (TENIS) for medical residents at the Tenriurgent issue. There has never been a greater need forEndowed Chair Assis. Prof.
Eisuke KURODA (Graduate School of Medicine)

Hospital.

healthcare workers engaged in infectious disease treatment

Endowed Chair Assis. Prof.
Minako IKEGAKI (Graduate School of Medicine)bacteriological laboratory technicians, and pharmacists. Our

Specially Appointed Researcher
Akiko OKURA (Graduate School of Medicine)disease treatment and infection control, contributing toand infection control, such as infection control nurses,
team will train the next generation of leaders in infectious

We conducted a site visit towards the resumption of the Tropical Infectious Disease Physician Training on theThailand-Myanmar border, which involves learning on-site.

infection control measures in local communities, Japan, andthe world.

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Division of Fostering Required
Medical Human Resources
Overview

Medical Informatics Team

It is necessary to analyze the sample quickly for infectious disease control, but it isInformation, Fostering, Innovation▍Summary of Results for FY2023

also very important to link the sample with medical information. Therefore, we aim
to develop human resources who can build a new advanced medical information

We initiated operations of the “CiDER-

occur one after another, and to become a hub for medical information education

ED U ” p lat fo r m in A p ril 2 0 2 2 , a n d byboth in Japan and overseas. In addition, we will develop an educational web content

the fiscal year 2023, we had released

platform that provides correct medical information about infectious diseases, aiming

33 educational content pieces to trainprovide a learning environment where anyone, anywhere, anytime can learn the

medical personnel. This update increased

appropriate information about infectious diseases.

Research Activity

system that can respond to emerging infectious diseases that are expected to

Result 1: Infectious Disease Education Practices

1,035 accounts, bringing the total numberof registered accounts to 4,359. Platform
enhancements have improved the user

Division of Fostering Required Medical Human Resources

experience, and with the introduction of a
new survey feature, we can now collectvaluable feedback from users (see ﬁgure,
CORE-ID 2022 Completion Survey results).
CiDER-EDU is utilized by diverse healthcare professionals, including physicians, pharmacists, clinicaltechnologists, and nurses. This diversity fosters an enhancement of infectious disease knowledge across all
healthcare workers and contributes to developing future leaders who will be crucial in managing infectious
disease control.

Result 2: Veriﬁcation of Sample Management Program
We used pathology specimens to conduct a verification experiment for the medical information linkage of thesample management program. The linkage with medical information was established and veriﬁed through a sample
management program integrated with the Clinical Data Collecting System (CDCS), part of OCR-Net (Osaka ClinicalResearch Network). This network, centered in the Kansai region, aims to advance high-quality clinical trials andresearch. In this system, the same subject ID is linked to the medical information in the CDCS and to the ID of theTeam Leader
Prof.

medical and sample information.
During the veriﬁcation process, pathology specimens (including those for infectious diseases) were individuallyToshihiro TAKEDA

registered with their collection sites and tissue diagnosis through the electronic medical record terminals,(Graduate School of Medicine)facilitating the linkage of specimens to clinical information. This linkage ensured the specimen management program

After graduating from Osaka University School of Medicine,<BIOPRISM> could display the information in a list format. In the fiscal year 2022, we registered a total of 113

he worked as a cardiologist and conducted basic research

specimens, and in 2023, we furthear optimized the linkage process, allowing for an additional 305 specimens to be

in cardiology at the graduate school. After graduation, heparticipated in a project to implement paperless electronic

Members

collected specimens (clinical sample ID), consolidated in the data center, enabling the centralized management of

medical records at the Department of Medical Informatics,

registered. Through this demonstration experiment, we have precisely identiﬁed the challenges within the sample
management program and aim to expand the range of registered specimen types in the coming ﬁscal year.

Osaka University Hospital. Since then, he has been involved
Endowed Chair Assoc. Prof.

Tomomi FUJII(Graduate School of Medicine)
Endowed Chair Assis. Prof.

Shoya WADA
(Graduate School of Medicine)in a wide range of clinical, research, and educational
activities in the field of medical informatics and has been
involved in teaching younger researchers through various
academic activities, including serving as a board member of
the Japan Society for Medical Informatics. He is also involvedin government policies related to medical information as amember of the revision task force for the “Guidelines for the
Safe Management of Medical Information Systems” of the
Ministry of Health, Labour and Welfare and as a member of

22

the “Study Group for the Development of Infrastructure for
the Utilization of Real World Data Research.”

23

Research Activity
Division of Scientiﬁc Information and Public Policy

Division of Scientific
Information
and Public Policy
Behavioral Public Policy Team
Behavioral Economics Unit
Human Science Unit

Information Analysis Team

Divisional Director
Prof.

Takashi NAKANOMathematical Analysis UnitELSI & Technology Unit
The team is composed of members from different organizations andﬁelds, and collects and analyzes information necessary for risk assessment
and policy evaluation, and carries out evidence-informed policy making(EIPM) and information dissemination.
We will address Unexpected Health Issues (UHI), such as infectious
diseases, which are diﬃcult to predict in advance but have the potential
to significantly damage physical and mental health, by integrating thehumanities and sciences, and enhance the resilience of society against
UHI.

24

25

Division of Scientific
Information and Public Policy

Behavioral Public Policy Team

Applying behavioral science andeconomics to infectious disease control

Behavioral Economics Unit
Overview

The Behavioral Economics Unit is conducting eﬀectiveness veriﬁcation of infection▍Summary of Results for FY2023

psychological characteristics into economics, and causal inference, a methodof analyzing causal relationships based on data. Specifically, we are developing
messages that apply behavioral economics to encourage infection prevention andvaccination behavior and examining their eﬀectiveness, examining the eﬀectivenessResearch Activity

control measures using behavioral economics, a field of study that incorporates

Result１: Surname order and revaccination intentions during
the COVID-19 pandemic
Japanese schools use alphabetical surname lists,
calling students with surnames appearing early sooner.

of priority measures to prevent the spread of infectious diseases, and analyzing theMonthly surveys from March 2020 to September 2022

impact of infection control measures such as declaring a state of emergency andasked participants about their childhood and adulttemporarily closing all schools nationwide on education and socioeconomic activities.

surname positions to investigate the role of surname
Division of Scientiﬁc Information and Public Policy

order in noncognitive skill formation. Using data from
December 2021 to September 2022, after COVID-19
vaccines became available, the study found thatwomen with early surnames had a 4% higher likelihoodof intending to revaccinate compared to men. The
surname effect was stronger for women, particularly
when mixed-gender lists were used, and was only observed for childhood surnames.
Yamamura, Tsutsui & Ohtake Surname order and revaccination intentions during the COVID-19 pandemic, Sci
Rep 14, 4750 (2024).

Result 2: The role of nudge-based messages on
the acceptability and download of COVID-19
contact tracing apps: survey experiments
The study investigated the effectiveness of nudge-based messages inpromoting the download of contact tracing apps in Japan, where uptake wasTeam Leader
Specially Appointed Prof.

Fumio OHTAKE
Fumio Ohtake is a specially appointed professor in the Center
for Infectious Disease Education and Research (CiDER), andadjunct professor in the Graduate School of Economics at
Osaka University. He earned his M.A. and a Ph.D. from Osaka

Members
Specially Appointed Assoc. Prof.

Shusaku SASAKI

26

University in 1985 and 1996, respectively, and a B.A. from
Kyoto University in 1983. He is an executive director of the
Association of Behavioral Economics and Finance, and aformer president of the Japanese Economic Association. His

low due to distrust. Two studies were conducted: Study 1 targeted 2,690
non-cooperative individuals based on smartphone location data, while Study
2 targeted 4,126 individuals whose web-search behavior could be tracked.
Nudge-based messages did not increase app downloads in either study. In
Study 1, the messages also did not enhance acceptability. However, in Study
2, with a more representative sample, nudge-based messages emphasizing
altruism, economic losses, and medical losses increased app acceptability,
although they did not increase app-related keyword searches.
Kurokawa, Sasaki & Ohtake “The role of nudge-based messages on theacceptability and download of COVID-19 contact tracing apps: survey
experiments,” JER (2024).

research topics are behavioral economics, labor economics,
income distribution, and household behavior. He is alsoa recipient of the 2005 Nikkei Prize for Excellent Books
in Economic Science; the 2005 Suntory Prize for Social
Science and Humanities; the 2005 Economist Prize; the2006 Ishikawa Prize of the Japanese Economic Association;and the 2008 Japan Academy Prize.

27

Division of Scientific
Information and Public Policy

Behavioral Public Policy Team

Understanding “human beings” from diverse
perspectives and applying them to infectious
disease control

Human Science Unit
Overview

To provide the basis for policy proposals on Unexpected Health Issues (UHI),▍Summary of Results for FY2023

damage physical and mental health, we take a complementary approach that

Research Activity

which are difficult to predict in advance but have the potential to significantly

Theory and Practice of Health Communication (1)combines contrasting perspectives on quantity and quality, the whole and theindividual, with particular attention to “human beings,” the members of society.

Our research group has continuously surveyed health literacy, beliefs about infection and infection prevention/risk behaviors related to COVID-19 since the early stages of the COVID-19 epidemic in Japan. One of the ﬁndings

Current projects include: social sensing of the social impact of UHI; ethnography

from these ongoing surveys was that individual health literacy and beliefs varied during the COVID-19 epidemicof people facing social dif ficulties and interpersonal suppor t workers;

in Japan, and these individual diﬀerences were associated with infection prevention/risk behaviors and fear ofdevelopment of health communication theories and techniques for unknown

infection. Our ﬁndings suggested that public messages from governments and public administrations to encouragerisks; and health promotion to increase resilience to UHI.

citizens to change their behavior (e.g., messages encouraging infection prevention behavior) should not be asingle message, but rather multiple messages that take into account individual differences in citizensʼ health
Division of Scientiﬁc Information and Public Policy

literacy and beliefs.

Theory and Practice of Health Communication (2)Next, our research group focused on the impact of healthliteracy on peopleʼs health behaviors and mental healthduring the COVID-19 epidemic in Japan. This study classiﬁed
health literacy characteristics into six segments - ʻMajority/
Social Defenseʼ, ʻSelf-judgment/Self-defenseʼ, ʻThreat

Team Leader

MembersProf.

Elli. W. SUGITA

Prof.

Asako MIURA

that individuals in the ʻExcessive Vigilance/Social Defenseʼ
segment tend to avoid hospital visits, which could increase(Graduate School of Human Sciences Prof. )long-term health risks. Meanwhile, the ʻThreat DenialʼIn 2002, she received her Ph.D. (Human Sciences) fromsegment downplays the risks of COVID-19, and individuals

Osaka University. After serving as a professor at Kwansei

in the ʻOptimism/Misinformation Aﬃnityʼ segment were easily inﬂuenced by misinformation and have low vaccination

Gakuin University and as a specially-appointed professor

intentions. These findings suggested that tailored information provision and support, matched to segment(full-time) at the Graduate School of Engineering Science,Prof.

Osaka University, she has been in her current position since

Yasuhiko MURAKAMI

2019. She specializes in social psychology. Her research(Graduate School of Human Sciences)interest has been consistent since the beginning of her

Kei HIRAIʻExcessive Vigilance/Social Defenseʼ - and examined theirimpact on health behaviors and vaccination. It was found(Graduate School of Human Sciences)

Assoc. Prof.

Denialʼ, ʻRumor Affinity/Optimismʼ, ʻCaution/Self-defenseʼ,characteristics, were essential in risk communication strategies. Targeted measures that meet individual needs are
key to protecting public health.

studies in social psychology: elucidating the mechanisms(Graduate School of Human Sciences)by which communication and interaction create “something

Specially Appointed Assis. Prof.

new.”

Mao YAGIHASHI
28

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Division of Scientific
Information and Public Policy

Information Analysis Team

Unveiling microscopic and macroscopic
mechanisms of infectious diseases throughmathematical science

Mathematical Analysis Unit
Overview

Mathematical Analysis Unit researches the mathematical representation and▍Summary of Results for FY2023

approaches that incorporate the concepts of reduction and emergence in naturalscience. Analyzing the information based on scientiﬁc and mathematical aspects,
we aim at integrating natural and social sciences and disseminating an accurate
information that will be the evidence of policy making.

Research Activity

modeling of infectious diseases through both microscopic and macroscopic

Result１：Data analysis of COVID-19 transmission
The spread of COVID-19 in Japan in the past was
analyzed using the Theil index, which is known
as an index of inequality in economics. The ﬁgure
below shows the results of analysis for the 7th
wave as a heat-map, with red and blue indicatingareas where more or fewer infected persons
were confirmed relative to the population ratio,

Division of Scientiﬁc Information and Public Policy

respectively. It can be seen that the wave of
infection that started in Kyushu and Okinawa, andthen spread northward. In addition, we continue toanalyze domestic infection trends and distribute information through our newsletter.

Result 2： Fixed point analyses for mathematical models of
infectious diseases
We performed stability analyses on nonlinear differential
equations for the broken-link model, which is a mathematicalmodel of infectious diseases that considers spillover eﬀects
when transmission links are unconnected, and for theclassical SIR model, respectively. As a result, we foundthe asymptotically stable fixed point for the broken-link
model, which well reproduces actual data. This implies thatmeasures to break the transmission link are likely to beeﬀective in order to bring the infection under control.

Team Leader
Prof.

Yoichi IKEDA
Prof. at CiDER since 2022. His main research field istheoretical hadron and nuclear physics. He found that ideas
in quantum physics are applicable to spread of infections

Members

among human societies, and proposed a new epidemic
model, the broken-link model. Based on ideas and techniques

Prof.

Takeshi NAKANO(Research Center for Nuclear Physics)of mathematics and physics, he aims to integrate natural andsocial sciences.

Specially Appointed Assoc. Prof.

Kenji SASAKI

30

31

Division of Scientific
Information and Public Policy

Information Analysis Team

Analysis of information and practical activities
to bridge the gap between science and society

ELSI & Technology Unit
Overview

ELSI & Technology Unit will work on social implementation through solution-▍Summary of Results for FY2023

health risks in pandemics and disasters, as well as theorizing risk communication
methods for collaboration with stakeholders. In addition, we will keep an eye on
the trends of academic publications and peopleʼs recognition and awareness of
the research results that form the basis for news and other information. ThroughResearch Activity

focused assessment of infection risks at mass gathering events and indirect

Result１：Quantitative evaluation of the eﬀectiveness and disadvantagesof infection control measures
In addition to evaluating the eﬀectiveness of infection control measuresat graduation and entrance ceremonies and sports games, we analyzed

these activities, we will develop society-aligned sciences to disseminate thethe change rates and reasons for mask usage and the decrease inﬁndings.

wellbeing associated with mask usage before and after downgrading of
the legal status of COVID-19. Thus, along with quantitative evaluationof the effectiveness and disadvantages of infection control measures
Division of Scientiﬁc Information and Public Policy

such as mask usage and regulations, we identiﬁed factors that promoteor reduce infection control behaviors such as mask usage. We also
developed and applied a wellbeing-based risk indicator that allows
comparison of the magnitude of various risk events that occurred
after the disaster and pandemic. Furthermore, we gave a lecture at
Knowledge Capital and made eﬀorts to disseminate information widely,

Figure Associations bet ween mask
usage and beliefs before and after thedowngrading of the legal status of COVID-19(Murakami, International Journal of Disaster
Risk Reduction, 97, 104072, 2023. doi:
10.1016/j.ijdrr.2023.104072)

including press releases of research results.

Result 2：Practical research on academic information distribution, andscience-society relations
We conducted a survey with the MBSJ and found that researchers
generally support preprints and open access publishing, but withreservations. Additionally, we developed materials for selecting
submission targets and critical appraisal, which are coordinated incollaboration with international initiatives (Fig.).

Team Leader

focusing on the mechanisms of life (held at Tokyo Tower, with 3,873

Michio MURAKAMI

visitors over three days), and 2) highlighting fairness in familiar contexts,

We have also shared information with professionals on multiple(Doctor of Engineering) degree in 2006. He has worked

occasions, including at the annual meeting of the JSPE (invited lecture),

Appointed Assistant Professor and Specially Appointed
Associate Professor (Lecturer) at The University ofAtsuo KISHIMOTOTokyo, and Associate Professor (Fukushima Medical

Kazuki IDE

in order to disseminate these achievements.

Technology), Post-Doctoral Research Fellow, SpeciallyProf.

Specially Appointed Assoc. Prof.

through a co-hosted event with Knowledge Capital.

He graduated from the Tokyo University with a PhD

Technology Agency (Tokyo University of Agriculture and(Institute for Datability Science)society from various perspectives. These eﬀorts include 1) an exhibition

Specially Appointed Prof.

as a Post-Doctoral Research Fellow at Japan Science andMembers

Furthermore, we have actively engaged in bridging science andUniversity). He has been a Specially Appointed Professor
at Center for Infectious Disease Education and Research,

Figure. Collaboration withinternational initiatives

Osaka University since August 2021, and has been the
Unit Leader since April 2022.

32

33

Publications［ Division of Microbiology and Immunology ］
1

Wataru Ise, Tomohiro Kurosaki, Tissues of origin matter toplasma cell longevity., Nature immunology, 25, 2, 194,
195, 2024.2, doi:10.1038/s41590-023-01731-7

2

Ryota Naito, Koichiro Ohmura, Shuhei Higuchi, Wataru Nakai,
Masako Kohyama, Tsuneyo Mimori, Akio Morinobu, Hisashi
Arase, Positive and negative regulation of the )Fќ receptorstimulatory activity of RNA-containing immune complexes by
RNase ., JCI insight , 8, 16, 2023.7, doi :10.1172/ jci .
insight.167799

4

Anais Joachim, Rudy Aussel, Léna Gélard, Fanghui Zhang,
Daiki Mori, Claude Grégoire, Sergio Villazala Merino, Mauro
Gaya, Yinming Liang, Marie Malissen, Bernard Malissen,
Defective LAT signalosome pathology in mice mimics
human IgG4-related disease at single-cell level, Journal of
Experimental Medicine, 220, 11, e20231028, 2023.11,
doi:10.1084/jem.20231028

5

6

Ryo Morita, Ritsuko Kubota-Koketsu, Xiuyuan Lu, Tadahiro
Sasaki, Emi E Nakayama, Yu-Chen Liu, Daisuke Okuzaki,
Daisuke Motooka, James Badger Wing, Yasunori Fujikawa,Yuji Ichida , Kiyoko Amo , Tetsushi Goto , Junichi Hara ,Michinori Shirano , Sho Yamasaki , Tatsuo Shioda ,COVID-19 relapse associated with SARS-CoV-2 evasion
from CD4+ T-cell recognition in an agammaglobulinemia
patient., iScience, 26, 5, 106685, 2023.5, doi:10.1016/
j.isci.2023.106685

7

Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke
Okuzaki, Masaya Arai, James B Wing, Shimon Sakaguchi,
Masahiro Yamamoto , A genetic method specificallydelineates Th1-type Treg cells and their roles in tumor
immunity., Cell reports, 42, 7, 112813, 2023.7, doi:10.
1016/j.celrep.2023.112813

8

9

34

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei
Sakakibara, Yuta Yamaguchi, Teruaki Murakami, Takayoshi
Morita , Yasuhiro Kato , Yu-Chen Liu , Daisuke Motooka ,Yoko Naito, Ayako Takuwa, Fuminori Sugihara, Kentaro
Tanaka , James B Wing , Kyuto Sonehara , Yoshihiko
Tomofuji, Ho Namkoong, Hiromu Tanaka, Ho Lee, Koichi
Fukunaga , Haruhiko Hirata , Yoshito Takeda , Daisuke
Okuzaki, Atsushi Kumanogoh, Yukinori Okada, Single-cell
analyses and host genetics highlight the role of innate
immune cells in COVID-19 severity., Nature genetics, 55,
5, 753, 767, 2023.4, doi:10.1038/s41588-023-01375-1

Laurent Schmied , Thuy T Luu , Jonas N Søndergaard ,Sophia H Hald , Stephan Meinke , Dara K Mohammad ,Sunitha B Singh , Corinna Mayer , Giovanna Perinetti
Casoni, Michael Chrobok, Heinrich Schlums, Giorgia Rota,
Hieu M Truong, Lisa S Westerberg, Greta Guarda, Evren
Alici, Arnika K Wagner, Nadir Kadri, Yenan T Bryceson,
Mezida B Saeed, Petter Höglund, SHP-1 localization to theactivating immune synapse promotes NK cell tolerance in
MHC class I deficiency ., Science signaling , 16, 780,
eabq0752, 2023.4, doi:10.1126/scisignal.abq0752
Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto,
Sarah Leach, Takao Arimori, Daisuke Higo, Floris J. van
Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki,
Masanori A . Murayama , Haruhiko Miyata , Kazuto
Nunomura , Bangzhong Lin , Akiyoshi Tani , Atsushi
Kumanogoh, Masahito Ikawa, James B. Wing, Daron M.
Standley , Junichi Takagi , Kazuhiro Suzuki , Celastrol
suppresses humoral immune responses and autoimmunity
by targeting the COMMD3/8 complex, Science
immunology , 8, 81, 2023.4, Doi :10.1126/ sciimmunol .
adc9324

11

Rahmi Dianty , Junki Hirano , Itsuki Anzai , Yuta Kanai ,Tsuyoshi Hayashi, Masae Morimoto, Chikako KataokaNakamura, Sakura Kobayashi, Kentaro Uemura, Chikako
Ono , Tokiko Watanabe , Takeshi Kobayashi , Kosuke
Murakami , Kenji Kikuchi , Kunimoto Hotta , Toshikazu
Yoshikawa , Shuhei Taguwa , Yoshiharu Matsuura ,Electrolyzed hypochlorous acid water exhibits potent
disinfectant activity against various viruses throughirreversible protein aggregation., Frontiers in microbiology,
14, 1284274, 2023, 10. 3389/fmicb.2023.1284274
Takayuki Abe, Yuki Marutani, Lin Deng, Chieko Matsui,
Masayoshi Fukasawa , Ryosuke Suzuki , Takaji Wakita ,Yoshiharu Matsuura, Ikuo Shoji, Hepatitis C Virus Disrupts
Annexin 5-Mediated Occludin Integrity throughDownregulation of Protein Kinase &њ (3.&њ) and 3.&ѠExpression, Thereby Promoting Viral Propagation., Journalof virology, 97, 6, e0065523, 2023, 10.1128/jvi.0065523

12

20

Tina Lusiany , Tohru Terada , Jun - Ichi Kishikawa , Mika
Hirose , David Virya Chen , Fuminori Sugihara , Hendra
Saputra Ismanto , Floris J van Eerden , Songling Li ,Takayuki Kato, Hisashi Arase, Matsuura Yoshiharu, Masato
Okada, Daron M Standley, Enhancement of SARS-CoV-2
Infection via Crosslinking of Adjacent Spike Proteins by
N-Terminal Domain-Targeting Antibodies., Viruses, 15, 12,2023, 10.3390/v15122421

21

Rae Maeda, Natsumi Seki, Yoshifumi Uwamino, Masatoshi
Wakui, Yu Nakagama, Yasutoshi Kido, Miwa Sasai, Shu
Taira , Naoya Toriu , Masahiro Yamamoto , Yoshiharu
Matsuura , Jun Uchiyama , Genki Yamaguchi , Makoto
Hirakawa, Yun-Gi Kim, Masayo Mishima, Motoko Yanagita,
Makoto Suematsu, Yuki Sugiura, Amino acid catabolite
markers for early prognostication of pneumonia in patientswith COVID-19., Nature communications, 14, 1, 8469,
2023, 10.1038/s41467-023-44266-z

Mauricio Aguilar Rangel, Patrick T Dolan, Shuhei Taguwa,
Yinghong Xiao , Raul Andino , Judith Frydman , High resolution mapping reveals the mechanism and contributionof genome insertions and deletions to RNA virus evolution.,
Proceedings of the National Academy of Sciences of theUnited States of America, 120, 31, e2304667120, 2023,
10.1073/pnas.2304667120

13

Miyuki Kimura, Risa Matsuoka, Satoshi Taniguchi, Junki
Maruyama , Slobodan Paessler , Saori Oka , Atsushi
Yamashita , Takasuke Fukuhara , Yoshiharu Matsuura ,Hideki Tani, Inhibitors of cannabinoid receptor 1 suppress
the cellular entry of Lujo virus., Virology, 587, 109867,
2023, 10.1016/j.virol.2023.109867

14

Emiko Urano, Yumi Itoh, Tatsuya Suzuki, Takanori Sasaki,
Jun-Ichi Kishikawa, Kanako Akamatsu, Yusuke Higuchi,
Yusuke Sakai , Tomotaka Okamura , Shuya Mitoma ,Fuminori Sugihara , Akira Takada , Mari Kimura , Shuto
Nakao, Mika Hirose, Tadahiro Sasaki, Ritsuko Koketsu,
Shunya Tsuji, Shota Yanagida, Tatsuo Shioda, Eiji Hara,
Satoaki Matoba , Yoshiharu Matsuura , Yasunari Kanda ,Hisashi Arase, Masato Okada, Junichi Takagi, Takayuki
Kato, Atsushi Hoshino, Yasuhiro Yasutomi, Akatsuki Saito,
Toru Okamoto, An inhaled ACE2 decoy confers protection
against SARS - CoV -2 infection in preclinical models .,Science translational medicine, 15, 711, eadi2623, 2023,
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15

19

Nagisa Tokunoh, Shigeyuki Tamiya, Masato Watanabe,
Toru Okamoto, Jessica Anindita, Hiroki Tanaka, Chikako
Ono, Toshiro Hirai, Hidetaka Akita, Yoshiharu Matsuura,
Yasuo Yoshioka, A nasal vaccine with inactivated wholevirion elicits protective mucosal immunity against SARSCoV-2 in mice., Frontiers in immunology, 14, 1224634,
2023, 10.3389/ÀPPX.2023.1224634

16

Juan-Vicente Bou, Shuhei Taguwa, Yoshiharu Matsuura,
Trick-or-Trap: Extracellular Vesicles and Viral Transmission.,
Vaccines, 11, 10, 2023, 10.3390/vaccines11101532

17

Adi Ariffianto, Lin Deng , Takayuki Abe , Chieko Matsui,
Masahiko Ito, Akihide Ryo, Hussein Hassan Aly, Koichi
Watashi, Tetsuro Suzuki, Masashi Mizokami, Yoshiharu
Matsuura , Ikuo Shoji , Oxidative stress sensor Keap 1
recognizes HBx protein to activate the Nrf2/ARE signaling
pathway, thereby inhibiting hepatitis B virus replication.,
Journal of virology, 97, 10, e0128723, 2023, 10.1128/
jvi.01287-23

Atsushi Kawai, Nagisa Tokunoh, Eigo Kawahara, Shigeyuki
Tamiya, Shinya Okamura, Chikako Ono, Jessica Anindita,
Hiroki Tanaka , Hidetaka Akita , Sho Yamasaki , Jun
Kunisawa, Toru Okamoto, Yoshiharu Matsuura, Toshiro
Hirai, Yasuo Yoshioka, Intranasal immunization with an
RBD-hemagglutinin fusion protein harnesses preexisting
immunity to enhance antigen - specific responses ., The
Journal of clinical investigation, 133, 23, 2023, 10.1172/
JCI166827

22

Shohei Minami, Tomohiro Kotaki, Yusuke Sakai, Shinya
Okamura, Shiho Torii, Chikako Ono, Daisuke Motooka,
Rina Hamajima, Ryotaro Nouda, Jeffery A Nurdin, Moeko
Yamasaki, Yuta Kanai, Hirotaka Ebina, Yusuke Maeda,
Toru Okamoto , Taro Tachibana , Yoshiharu Matsuura ,Takeshi Kobayashi, Vero cell-adapted SARS-CoV-2 strainshows increased viral growth through furin - mediatedefficient spike cleavage ., Microbiology spectrum ,e0285923, 2024, 10.1128/spectrum.02859-23

23

Itsuki Anzai, Junso Fujita, Chikako Ono, Yoichiro Kosaka,
Yuki Miyamoto, Shintaro Shichinohe, Kosuke Takada, Shiho
Torii, Shuhei Taguwa, Koichiro Suzuki, Fumiaki Makino,
Tadahiro Kajita, Tsuyoshi Inoue, Keiichi Namba, Tokiko
Watanabe , Yoshiharu Matsuura , Characterization of aneutralizing antibody that recognizes a loop region adjacentto the receptor-binding interface of the SARS-CoV-2 spikereceptor - binding domain ., Microbiology spectrum ,e0365523, 2024, 10.1128/spectrum.03655-23

24

Anastasia Armimi, $ÀQD Firdaus Syuaib, Katherine Vanya,
Marselina Irasonia Tan, Dessy Natalia, David Virya Chen,
Chikako Ono, Yoshiharu Matsuura, Anita Artarini, SARSCoV -2 Neutralization Assay System using Pseudo lentivirus, Indonesian Biomedical Journal, 15, 2, 179, 184,
2024, 10.18585/inabj.v15i2.2210

25

Maorui Zhang, Yuta Fukushima, Kosuke Nozaki, Hideyuki
Nakanishi, Jia Deng, Noriyuki Wakabayashi, Keiji Itaka,
Enhancement of bone regeneration by coadministration ofangiogenic and osteogenic factors using messenger RNA,Inflammation and Regeneration, 43, 1, 32, 2023, doi:10.
1186/s41232-023-00285-3

26Xuan Du , Erica Yada , Yuki Terai , Takuya Takahashi ,Hideyuki Nakanishi, Hiroki Tanaka, Hidetaka Akita, Keiji
Itaka, Comprehensive Evaluation of Lipid Nanoparticles andPolyplex Nanomicelles for Muscle-Targeted mRNA Delivery,
Pharmaceutics, 15, 9, 2291, 2291, 2023, doi:10.3390/
pharmaceutics15092291

27

Kida H, Yamasaki Y, Feril Jr LB, Endo H, Itaka K, Tachibana
K, (IÀFLHQW mRNA Delivery with Lyophilized Human Serum
Albumin-Based Nanobubbles, Nanomaterials, 13, 7, 1283,
1283, 2023, doi:10.3390/nano13071283

28

Tsou H, Wu C, Chan L, Kataoka K, Itokazu N, Tsuzuki M,
Hu H, Zhuo G, Itaka K, Lin C., Administration of mRNANanomedicine-Augmented Calvarial Defect Healing via
Endochondral 2VVLÀFDWLRQ., Pharmaceutics, 15, 7, 1965,
1965, 2023, doi:10.3390/pharmaceutics15071965

29

Koga T, Kida H, Yamasaki Y, Feril LB, Jr. Endo H, Itaka K,
Abe H, Tachibana K., Intracranial Gene Delivery Mediated byAlbumin-Based Nanobubbles and Low-Frequency Ultrasound,
Nanomaterials, 14, 285, 2024, Doi:10.3390/nano14030285

Information

3

Shu Horiuchi, Takuya Koike, Hirofumi Takebuchi, Katsuaki
Hoshino , Izumi Sasaki , Yuri Fukuda - Ohta , Tsuneyasu
Kaisho, Daisuke Kitamura, SpiB regulates the expressionof B - cell - related genes and increases the longevity ofmemory B cells, Frontiers in Immunology, 14, 2023.1,
doi:10.3389/ÀPPX.2023.1250719

10

18

Kentaro Uemura, Haruaki Nobori, Akihiko Sato, Shinsuke
Toba, Shinji Kusakabe, Michihito Sasaki, Koshiro Tabata,
Keita Matsuno, Naoyoshi Maeda, Shiori Ito, Mayu Tanaka,
Yuki Anraku , Shunsuke Kita , Mayumi Ishii , Kayoko
Kanamitsu, Yasuko Orba, Yoshiharu Matsuura, William W
Hall, Hirofumi Sawa, Hiroshi Kida, Akira Matsuda, Katsumi
Maenaka , 2- thiouridine is a broad - spectrum antiviralnucleoside analogue against positive-strand RNA viruses.,
Proceedings of the National Academy of Sciences of theUnited States of America, 120, 42, e2304139120, 2023,
10.1073/pnas.2304139120［ Division of Fostering Required Medical Human Resources ］
1

Fujihara T, Kimura K, Matsuo H, Sada RM, Hamaguchi S,
Yamamoto G, Yamakura T, Kutsuna S., Aneurysm Infection
Caused by Desulfovibrio desulfuricans., Emerg Infect Dis.,29, 8, 1680, 1681, 2023, doi:10.3201/eid2908.230403.

2

Kashihara E , Sada RM , Tsugihashi Y , Obayashi H ,Nakamura A, Abe N, Miyake H, Akebo H., Efficacy and
Safety of Cefmetazole for Bacteremia Caused by ExtendedSpectrum ћ -Lactamase -Producing Enterobacterales vsCarbapenems: A Retrospective Study., Open Forum InfectDis., 10, 10, ofad 502, 2023, doi:10.1093/RÀG/ofad502.

3

Miyake H, Minoda Sada R, Manabe A, Tsugihashi Y, Hatta
K ., Factors and Reasons for Non - vaccination among
Patients with Systemic Lupus Erythematosus: A Singlecentre, Cross-sectional Study., Intern Med., 62, 17, 2483,
2491, 2023, doi:10.2169/internalmedicine.1067-22.

4

Miyake H, Sada RM, Akebo H, Tsugihashi Y, Hatta K.,
Polypharmacy prevalence and associated factors inpatients with systemic lupus erythematosus : A single centre, cross-sectional study., Mod Rheumatol., 34, 1, 106,
112, 2023, doi:10.1093/mr/roac155.

5

Miyake H, Sada RM, Akebo H, Tsugihashi Y, Hatta K.,
Prevalence and factors associated with polypharmacy
among patients with rheumatoid arthritis: a single-centre,
cross - sectional study ., Clin Rheumatol ., 42, 9, 2287,
2295, 2023, Doi:10.1007/s10067-023-06646-0

6

Nagatomi H , Sada RM , Abe N , Miyake H , Akebo H .,Reviving Sternheimer stain: A single-center retrospective
study to detect the diagnostic utility of urinary tract
infections in the emergency department., J Infect Chemot,
S 1341-321 X , 24, In Press , 2024, doi . org /10.1016/ j .
jiac.2024.02.019

7

Murakami M, Yagihashi M, Sada RM., 6FLHQWLÀF consensus
views are useful, but dangerous, without a code of ethics., JRadiol Prot ., 43, 3, 2023, doi :10.1088/1361-6498/
ace265.

8

Miyake H, Sada RM, Tsugihashi Y, Hatta K., Single-centre,
cross-sectional study on the factors and reasons for nonvaccination among patients with rheumatoid arthritis., Mod
Rheumatol, 34, 1, 79, 86, 2023, doi:10.1093/mr/road003.

9

Konishi K, Onozuka D, Takatera S, Matsuo H, Yoshida H,
Hamaguchi S, Yamamoto S, Sada RM, Suzuki K, Kutsuna S.,
Protocol for a Randomized, Open-Label Clinical Trial on the
Effect of Mouthwash on Salivary SARS-CoV-2 Load., Life
(Basel)., 13, 12, 2312, 2023, doi:10.3390/life13122312.

10

Sada RM, Matsuo H, Motooka D, Kutsuna S, Hamaguchi S,
Yamamoto G, Ueda A., Clostridium butyricum Bacteremia
Associated with Probiotic Use, Japan., Emerg Infect Dis.,30, 4, 665, 671, 2024, doi:10.3201/eid3004.231633.

35

11

Eisuke Kuroda , Yuka Koizumi , Zhenyu Piao , Hiroki
Nakayama , Kazunori Tomono , Kazunori Oishi , Shigeto
Hamaguchi, Yukihiro Akeda, Establishment of a modified
opsonophagocytic killing assay for anti-pneumococcal surface
protein A antibody, Journal of Microbiological Methods, 212,
106804, 2023, doi:10.1016/j.mimet.2023.106804.

12

Chieko Yokota , Kosuke Fujimoto, Natsuko Yamakawa ,Masamitsu Kono, Daichi Miyaoka, Masaki Shimohigoshi,
Miho Uematsu , Miki Watanabe , Yukari Kamei , Akira
Sugimoto, Natsuko Kawasaki, Takato Yabuno, Tomotaka
Okamura, Eisuke Kuroda, Shigeto Hamaguchi, Shintaro
Sato, Muneki Hotomi, Yukihiro Akeda, Ken J Ishii, Yasuhiro
Yasutomi, Kishiko Sunami, Satoshi Uematsu, Prime-boosttype PspA 3+2 mucosal vaccine protects cynomolgus
macaques from intratracheal challenge with pneumococci,
Inflammation and Regeneration, 43, 55, 2023,
doi:10.1186/s41232-023-00305-2.
Fujihara T, Kimura K, Matsuo H, Sada RM, Hamaguchi S,
Yamamoto G, Yamakura T, Kutsuna S., Aneurysm Infection
Caused by Desulfovibrio desulfuricans, Emerg Infect Dis.,29, 8, 1680, 1681, 2023, 10.3201/eid2908.230403.

14

Shizukuishi S , Ogawa M , Kuroda E , Hamaguchi S ,Sakuma C, Kakuta S, Tanida I, Uchiyama Y, Akeda Y, Ryo
A, Ohnishi M., Pneumococcal sialidase promotes bacterial
survival by ÀQH-tuning of pneumolysin-mediated membrane
disruption, Cell Reports, 43, 3, 113962, 2024, 10.1016/
j.celrep.2024.113962

15

Morimura A, Taniguchi M, Takei H, Sakamoto O, Naono N,
Akeda Y, Onozuka D, Yoshimura J, Tomono K, Kutsuna S,
Hamaguchi S, Using novel micropore technology combinedwith artificial intelligence to differentiate Staphylococcus
aureus and Staphylococcus epidermidis, 6FLHQWLÀF Reports,
14, 6994, 2024, 10.1038/s41598-024-55773-4

17

Ryohei Yamamoto, Hajime Yamazaki, Shungo Yamamoto,
Yuna Ueta, Ryo Ueno, Yosuke Yamamoto, Dose-response
relationship between diarrhea quantity and mortality in
critical care patients: A retrospective cohort study., PloS one,
18, 2, e0280806, 2023, 10.1371/journal.pone.0280806

18

Tatsuya Fujihara, Shungo Yamamoto, Daisuke Sakamoto,
Satoshi Kutsuna , Fever in a heart transplant recipient
related to remaining LVAD component ., IDCases , 33,
e01822, 2023, 10.1016/j.idcr.2023.e01822

19

1

20

Yamamoto G, Usefulness of mecA gene test in the surgicalinfectious disease setting, Journal of Japan Society for
Surgical Infection , 20, 1, 29, 33, 2023, https :// doi .
org/10.24679/gekakansen.20.1̲29

21

Katsuki Okada, Kento Sugimoto, Shoya Wada, Shozo
Konishi, Shirou Manabe, Yasushi Matsumura, Toshihiro
Takeda. Development of the Clinical Specimen Information
Management System for Multicenter Clinical Studies. Stud
Health Technol Inform, 310, 119–123, 2024, doi: 10.3233/
SHTI230939.

10

Eiji Yamamura, Youki Kohsaka, Yoshiro Tsutsui, Fumio Ohtake,

2

3

36

11

Makoto Kuroki, Shusaku Sasaki, Nudging public budgetRIÀFHUV: A ÀHOG-based survey experiment, Public Budgeting& Finance, 43, 3, 3, 20, 2023.7, doi:10.1111/pbaf.12345

Yamamura, E, Tsutsui, Y, Ohtake, F, Surname order andrevaccination intentions during the COVID-19 pandemic,
6FLHQWLÀF Reports, 14, 4750, 2024.2, doi:10.1038/s41598-

12

Shusaku Sasaki, Takahiro Kubo, Shodai Kitano, Prosocialand Financial Incentives for Biodiversity Conservation: A
Field Experiment Using a Smartphone App, arXiv, 2402,

024-55543-2

18047, 1, 45, 2024.2

4

Chisa Nakashima, Fumio Ohtake, Atushi Otsuka, Tacklingsteroid phobia: Insights from behavioural economics andpsychological approaches , JEADV Clinical Practice ,2023.1, doi:10.1002/jvc2.286

5Eiji Yamamura, Yoshiro Tsutsui, Fumio Ohtake, The Effectof Primary School Education on Preventive Behaviours
during COVID-19 in Japan, Sustainability, 15, 11, 8655,
2023.5, doi:10.3390/su15118655

Hirofumi Kurokawa, Shusaku Sasaki, Fumio Ohtake, Therole of nudge-based messages on the acceptability anddownload of COVID -19 contact tracing apps : survey
experiments, The Japanese Economic Review, 2024.2,
doi:10.1007/s42973-024-00152-x

6

Shuhei Kitamura, Nils-Petter Lagerlöf, Cities, &RQÁLFW, andCorridors, 2023.6, doi:10.31219/osf.io/cfrzs

7

Shuhei Kitamura, Quantifying the ,QÁXHQFH of Climate on
Human Mind and Culture : Evidence from Visual Art ,2023.7, doi:10.48550/arXiv.2307.15540

8

Shuhei Kitamura, Aya S. Ihara, Semantic Processing of
Political Words in Naturalistic Information Differs by
Political Orientation, 2023.5

9Shuhei Kitamura, Katsunori Yamada, The Constructive and
Destructive Power of Social Norms in the Presence ofAuthoritative ,QÁXHQFH, American Psychologist, 2023.12,
doi:10.1037/amp0001288

19

20

21

Hiroshi Murayama, Shusaku Sasaki, Yuta Takahashi, Mai
Takase , Atsuko Taguchi , Message framing effects on
attitude and intention toward social participation in old age,
BMC Public Health, 23, 1713, 1, 10, 2023.9, doi:10.1186/
s12889-023-16555-1

Gender Differences of the Effect of Vaccination on Perceptionsof COVID-19 and Mental Health in Japan, Vaccines, 11, 4,
822, 2023.4, doi:10.3390/vaccines11040822

13

18

Yoshie Yamada , Sayaka Shimizu, Shungo Yamamoto ,Yoshinori Matsuoka, Yusuke Tsutsumi, Asuka Tsuchiya,
Tsukasa Kamitani , Hajime Yamazaki , Yusuke Ogawa ,Shunichi Fukuhara, Yosuke Yamamoto, Prehospital shockindex predicts 24-h mortality in trauma patients with anormal shock index upon emergency department arrival.,
The American journal of emergency medicine, 70, 101, 108,2023, 10.1016/j.ajem.2023.05.008［ Division of Scientiﬁc Information and Public Policy ］
Eiji Yamamura, Youki Kohsaka, Yoshiro Tsutsui, Fumio Ohtake,
Association between the COVID-19 Vaccine and Preventive
Behaviors: Panel Data Analysis from Japan, Vaccines, 11, 4,
810, 2023.4, doi:10.3390/vaccines11040810

17

14

Michio Murakami, Kai Hiraishi, Mei Yamagata, Daisuke
Nakanishi, Andrea Ortolani, Nobuhiro Mifune, Yan Li, Asako
Miura, Differences in and associations between belief in justdeserts and human rights restrictions over a 3-year period
in 5 countries during the COVID-19 pandemic, PeerJ, 11,e16147, 2023.9, doi:10.7717/peerj.16147

15

Michio Murakami, Mei Yamagata, Asako Miura, Explorationof factors associated with mask - wearing and handdisinfection in Japan after the coronavirus disease
outbreak: A longitudinal study , International Journal ofDisaster Risk Reduction , 98, 104107, 2023.11, doi .
org/10.1016/j.ijdrr.2023.104107

16

Arinobu Hori , Michio Murakami , Masaharu Tsubokura ,Against an insufficient intervention for patients withalcoholism or PTSD: An activity report on a psychiatricclinic after the 2011 complex disaster in Fukushima ,Japan, International Journal of Disaster Risk Reduction,
96, 103990, 2023.9, doi:10.1016/j.ijdrr.2023.103990

Moe Kawashima , Toyoaki Sawano , Michio Murakami ,Nobuaki Moriyama, Kenmei Kitazawa, Yuna Uchi, Saori
Nonaka, Naomi Ito, Hiroaki Saito, Toshiki Abe, Mamoru
Sakakibara, Kazuko Yagiuchi, Mako Otsuki, Arinobu Hori,
Akihiko Ozaki, Chika Yamamoto, Tianchen Zhao, Taiga
Uchiyama, Tomoyoshi Oikawa, Shinichi Niwa, Masaharu
Tsubokura , Association between the deaths indirectly
caused by the Fukushima Daiichi nuclear power plant
accident (disaster-related deaths) and pre-disaster longterm care certificate level: A retrospective observational
analysis, International Journal of Disaster Risk Reduction,
96, 103989, 2023.9, doi:10.1016/j.ijdrr.2023.103989
Michio Murakami , Bi - directional associations between
mask usage and beliefs about reasons for masking before
and after the downgrading of the legal status of COVID-19
in Japan : A longitudinal study , International Journal ofDisaster Risk Reduction, 97, 104072, 2023, doi:10.1016/
j.ijdrr.2023.104072
Hiroki Yoshimura , Toyoaki Sawano , Michio Murakami ,Yuna Uchi , Moe Kawashima , Kemmei Kitazawa , Saori
Nonaka, Naomi Ito, Hiroaki Saito, Toshiki Abe, Nobuaki
Moriyama, Mamoru Sakakibara, Kazuko Yagiuchi, Mako
Otsuki , Arinobu Hori , Akihiko Ozaki , Chika Yamamoto ,Tianchen Zhao , Taiga Uchiyama , Tomoyoshi Oikawa ,Shinichi Niwa , Masaharu Tsubokura , Categorization ofdisaster - related deaths in Minamisoma city after the
Fukushima nuclear disaster using clustering analysis .,Scientific reports , 14, 1, 2946, 2024.2, doi :10.1038/
s41598-024-53165-2
Michio Murakami , Kyoko Ono , Yoshitake Takebayashi ,Masaharu Tsubokura , Shuhei Nomura , Comparing therisks of environmental carcinogenic chemicals in Japan
using the loss of happy life expectancy indicator ,Environmental Research, 118637, 2024.3, doi:10.1016/
j.envres.2024.118637
Kemmei Kitazawa , Toyoaki Sawano , Yuna Uchi , Moe
Kawashima , Hiroki Yoshimura , Michio Murakami, Saori
Nonaka, Hiroaki Saito, Mamoru Sakakibara, Kazuko Yagiuchi,
Mako Otsuki, Akihiko Ozaki, Chika Yamamoto, Tianchen
Zhao, Taiga Uchiyama, Tomoyoshi Oikawa, Shinichi Niwa,
Masaharu Tsubokura, Disaster-related deaths with alcoholrelated diseases after the Fukushima Daiichi nuclear power
plant accident: case series., Frontiers in public health, 11,1292776, 2023, doi:10.3389/fpubh.2023.1292776

22

Mao Yagihashi , Michio Murakami , Mai Kato , Asayo
Yamamura, Asako Miura, Kei Hirai, Exploratory study tocharacterise the individual types of health literacy andbeliefs and their associations with infection prevention
behaviours amid the COVID -19 pandemic in Japan: alongitudinal study, PeerJ, 12, e16905, 2024.2, doi:10.7717/
peerj.16905

23

Kosuke Shirai, Momo Takada, Michio Murakami, Susumu
Ohnuma , Kazuo Yamada , Masahiro Osako , Tetsuo
Yasutaka, Factors LQÁXHQFLQJ acceptability of ÀQDO disposalof incinerated ash and decontaminated soil from TEPCOʼs
Fukushima Daiichi nuclear power plant accident, Journalof Environmental Management, 345, 118610, 2023.11,
doi:10.1016/j.jenvman.2023.118610

24

Akihiko Ozaki, Hiroaki Saito, Yudai Kaneda, Toyoaki Sawano,
Yoshitaka Nishikawa , Michio Murakami , Masaharu
Tsubokura, Kei Hirai, Hiromichi Ohira, Long-term uptake rateof a breast cancer screening program in Fukushima, Japan,
following the 2011 Triple Disaster : a retrospective
observational study, 6FLHQWLÀF Reports, 13, 1, 6654, 2023.4,
doi:10.1038/s41598-023-33717-8

25

Moe Kawashima, Michio Murakami, Tomoyuki Kobayashi,
Yoshitake Takebayashi , Masaharu Tsubokura , Tetsuo
Yasutaka, Tomoaki Tamaki, Post-traumatic growth causedby the Great East Japan Earthquake and response tocoronavirus disease 2019, International Journal of Disaster
Risk Reduction , 95, 103917, 2023.9, doi :10.1016/
j.ijdrr.2023.103917

26

Momo Takada , Michio Murakami , Susumu Ohnuma ,Yukihide Shibata, and Tetsuo Yasutaka, Public attitudes
toward the ÀQDO disposal of radioactively contaminated soil
resulting from the Fukushima Daiichi Nuclear Power Station
accident, Environmental Management, 2024.2,
doi:10.1007/s00267-024-01938-w.

27

Jun - ichi Takeshita , Michio Murakami , Masashi Kamo ,Wataru Naito, Tetsuo Yasutaka, Seiya Imoto, Quantifying
the effect of isolation and negative certification on
COVID-19 transmission, 6FLHQWLÀF Reports, 13, 1, 11264,
2023.7, doi:10.1038/s41598-023-37872-w

28

Akihiko Ozaki, Michio Murakami, Claire Leppold, :LOGÀUH
exposure and lung cancer survival , JAMA Oncology ,2024.1, doi:10.1001/jamaoncol.2023.6123

29

Michio Murakami, Mao Yagihashi, Ryuichi Minoda Sada,
Scientific consensus views are useful , but dangerous ,without a code of ethics, Journal of Radiological Protection,
43, 3, 34501, 2023.7, doi:10.1088/1361-6498/ace265

30

Sakamoto K, Kawamura K, Ruan P, Uchida S, Akiyama R,
Lee C, Ide K, Tanaka S, Hiraoka S, Automated evaluation ofmasseter muscle volume : Deep learning prognostic
approach in oral cancer., BMC Cancer., 24, 128 (11 pp),2024.1, doi:10.1186/s12885-024-11873-y

31

Ide K, Hawke P, Nakayama T, Can ChatGPT be considered
an author of a medical article?, J Epidemiol., 33, 7, 381,
382, 2023.6, doi:10.2188/jea.JE20230030

32

Ide K, Nakayama J, Researchers support preprints andopen access publishing , but with reservations : A
questionnaire survey of MBSJ members., Genes Cells.,
28, 5, 333, 337, 2023.5, doi:10.1111/gtc.13015

33

Yan Lyu, Sinya Aoki, Takumi Doi, Tetsuo Hatsuda, Yoichi
Ikeda, Jie Meng, Doubly Charmed Tetraquark Tcc+ from
Lattice QCD near Physical Point, Physical Review Letters,
131, 16, 161901, 2023.10, doi:10.1103/PhysRevLett.131.

Information

13

16

Shungo Yamamoto, Caveats for validating the diagnostic
accuracy of diagnostic or classification criteria for IE .,Clinical infectious diseases : an RIÀFLDO publication of the
Infectious Diseases Society of America, 2023, 10.1093/
cid/ciad395

161901

34

Kotaro Murakami, Yutaro Akahoshi, Sinya Aoki, Takumi
Doi, Kenji Sasaki(HAL QCDCollaboration), Lattice quantum
chromodynamics (QCD) studies on decuplet baryons asmeson ‒baryon bound states in the HAL QCD method ,Progress of Theoretical and Experimental Physics, 2023,
4, 2023.4, doi:10.1093/ptep/ptad044

35

Akihiko Ozaki , Michio Murakami , Tetsuya Tanimoto ,Masaharu Tsubokura , Science as the foundation for
decision - making : China ʼ s ambivalent response to
Fukushimaʼs tritium water discharge, Journal ofRadiological Protection, 44, 1, 014501, 014501, 2024.

36

Ide K, Looking Over the Edge ̶ A case of fake peerreview and ÀQGLQJV of an in-house investigation., Against
the Grain (US)., 35, 3, 60, 61, 2023.6

37

［ Plannning

1

2

8

Michio Murakami , Akihiko Ozaki , Kyoko Ono , Shuhei
Nomura, Yoshitake Takebayashi, Masaharu Tsubokura,Comparing the risks of diabetes, psychological distress, andradiation-induced cancer exposure after the Fukushimadisaster using the loss of happy life expectancy, 2023.5

Atsushi Kobayashi , Tetsuya Hirata , Taishi Shimazaki ,Yoshiko Munesue, Keisuke Aoshima, Takashi Kimura, Junko
Nio - Kobayashi , Rie Hasebe , Atsuko Takeuchi , Yuichi
Matsuura, Satoshi Kusumi, Daisuke Koga, Yasushi Iwasaki,
Taroh Kinoshita, Shirou Mohri, Tetsuyuki Kitamoto, A point
mutation in GPI-attachment signal peptide accelerates thedevelopment of prion disease., Acta neuropathologica, 145,
5, 637, 650, 2023.5, doi:10.1007/s00401-023-02553-5
Yi-Shi Liu, Yicheng Wang, Xiaoman Zhou, Linpei Zhang,
Ganglong Yang , Xiao - Dong Gao , Yoshiko Murakami ,Morihisa Fujita, Taroh Kinoshita, Accumulated precursorsof specific GPI - anchored proteins upregulate GPI
biosynthesis with ARV1., The Journal of cell biology, 222,
5, 2023.5, doi:10.1083/jcb.202208159
Jun-Ichi Nishimura, Antoine Soubret, Noriko Arase, Simon
Buatois, Masaki Hotta, Jean-Eric Charoin, Yoshikazu Ito,
Sasha Sreckovic, Hiroyuki Takamori, Christoph Bucher,
Yasutaka Ueda , Jules Hernández - Sánchez , Keisuke
Gotanda, Gregor Jordan, Kenji Shinomiya, Julia Ramos, Jin
Seok Kim, Jens Panse, Régis Peffault de Latour, Alexander
Röth, Eiichi Morii, Hubert Schrezenmeier, Yoshitaka Isaka,
Simona Sica, Yuzuru Kanakura, Sung-Soo Yoon, Taroh
Kinoshita, Ido Paz-Priel, Alexandre Sostelly, Mitigating DrugTarget - Drug Complexes in Patients With Paroxysmal
Nocturnal Hemoglobinuria Who Switch C 5 Inhibitors .,Clinical pharmacology and therapeutics, 113, 4, 904, 915,
2023.4, doi:10.1002/cpt.2851

4Shinji Matsumoto, Akikazu Harada, Minami Seta, Masayuki
Akita, Hidetoshi Gon, Takumi Fukumoto, Akira Kikuchi, Wnt
Signaling Stimulates Cooperation between GREB1 and
HNF 4 њ to Promote Proliferation in Hepatocellular
Carcinoma., Cancer research, 83, 14, 2312, 2327, 2023,
doi:10.1158/0008-5472.CAN-22-3518

5

Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu
Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi
Hirayama , Kazunori Yokoi , Atsushi Tanemura , Keisuke
Nimura, Masahito Ikawa, Tomoyoshi Soga, Akira Kikuchi,
GREB1 isoform 4 is specifically transcribed by MITF andrequired for melanoma proliferation., Oncogene, 42, 42,3142, 3156, 2023, doi:10.1038/s41388-023-02803-6

6

7

Kosuke Iguchi, Ryota Sada, Shinji Matsumoto, Hirokazu
Kimura, Toh Zen Y, Masayuki Akita, Hidetoshi Gon, Takumi
Fukumoto, and Akira Kikuchi., The DKK1-CKAP4 signal axis
promotes hepatocellular carcinoma aggressiveness., Cancer
Sci., 114, 2063, 2077, 2023, doi:10.1111/cas.15743

6

Michio Murakami, Shuhei Nomura, Hiroki Ando, Masaaki
Kitajima, Perceptions and responses to COVID-19 throughwastewater surveillance information and online searchbehavior: A randomized controlled trial, 2023.10

9

7

Michio Murakami , Bi - directional associations between
mask usage and the associated reasons before and after
the downgrading of the legal status of COVID-19 in Japan:
A longitudinal study, 2023.7

Mao Yagihashi , Michio Murakami , Mai Kato , Asayo
Yamamura, Asako Miura, Kei Hirai, Exploratory study tocharacterise the individual types of health literacy andbeliefs and their associations with infection prevention
behaviours amid the COVID -19 pandemic in Japan: Alongitudinal study, 2023.4

Akihiro Nagoya , Ryota Sada , Hirokazu Kimura , Hideki
Yamamoto, Koichi Morishita, Eiichi Miyoshi, Eiichi Morii,
Yasushi Shintani, and Akira Kikuchi., The DKK1-CKAP4
signal axis promotes hepatocellular carcinoma
aggressiveness., Trans. Lung Cancer Res,, 12, 408, 2023,
Doi:10.21037/tlcr-22-571

10

Katirai A, Garcia N, Ide K, Nakashima Y, Kishimoto A,
Situating the social issues of image generation models in
the model life cycle: a sociotechnical approach., 2023.12

8

Natsuko Yamauchi , Mako Otsuka , Tomohiro Ishikawa ,Yoshihiro Kakeji, Akira Kikuchi, Atsuhiro Masuda, Yuzo
Kodama, Yasuhiro Minami, Koki Kamizaki, Role of Wnt5bRor 1 signaling in the proliferation of pancreatic ductal
adenocarcinoma cells, Genes to Cells, 2024, doi.org/10.
1111/gtc.13115

9

Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada,
Keita Horitani , Osamu Tsukamoto , Kenta Kamikubo ,Seitaro Nomura , Shinji Matsumoto , Takeshi Harada ,Daisuke Motooka, Daisuke Okuzaki, Seiji Takashima, Issei
Komuro , Akira Kikuchi , Ichiro Shiojima , Wnt 5 a - YAP
signaling axis mediates mechanotransduction in cardiac
myocytes and contributes to contractile dysfunction
induced by pressure overload, iScience, 107146, 2023,
doi:10.1016/j.isci.2023.107146

10

Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher
Takaya Knight , Takayoshi Yamamoto , Takuo Hayashi ,Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick
Barker , Etsuo A Susaki , Masanori Taira , Masanori
Hatakeyama, The Helicobacter pylori CagA oncoprotein
disrupts Wnt/PCP signaling and promotes hyperproliferationof pyloric gland base cells., Science signaling, 16, 794,
eabp9020, 2023, doi:10.1126/scisignal.abp9020

11

Hideyuki Hara , Hironori Miyata , Junji Chida , Suehiro
Sakaguchi, Strain - dependent role of copper in prion disease
through binding to histidine residues in the N- terminal
domain of prion protein, Journal of Neurochemistry, 167, 3,
394, 409, 2023.11, doi:10.1111/jnc.15971

Information

3

5

Aminu Kende Abubakar , Yudai Kaneda, Akihiko Ozaki,
Hiroaki Saito , Michio Murakami , Daisuke Hori , Kenji
Gonda, Masaharu Tsubokura, Takahiro Tabuchi, Two-yearspan breast cancer screening uptake in Japan after the
COVID -19 pandemic and its association with the
COVID-19 vaccination, 2023.11

Management Oﬃce etc. ］

Preprints［ Division of Microbiology and Immunology ］

1David G. Priest, Takeshi Ebihara, Janyerkye Tulyeu, Jonas
Søndergaard , Shuhei Sakakibara , Fuminori Sugihara ,Shunichiro Nakao, Yuki Togami, Jumpei Yoshimura, Hiroshi
Ito, Shinya Onishi, Arisa Muratsu, Yumi Mitsuyama, Hiroshi
Ogura, Jun Oda, Daisuke Okuzaki, Hisatake Matsumoto,
James B. Wing, Non-classical CD45RBlo memory B-cells
are the majority of circulating antigen - specific B - cells
following mRNA vaccination and COVID -19 infection .,Research Square, 2024.1［ Division of Scientiﬁc Information and Public Policy ］
1

2

38

Sun Youn Lee, Shusaku Sasaki, Fumio Ohtake, Wearing
School Uniforms in Childhood Linked with Wearing AntiCOVID-19 Masks in Adulthood through Other-Regarding
Preferences: An Instrumental Variable Approach, 2023.1,
Osaka University CiDER Discussion Paper
Shusaku Sasaki, Takunori Ishihara, Hiroki Kato, Rebate
versus Matching , Again : Does Self - selection Matter ?,2023.5, Osaka University CiDER Discussion Paper

3

Mao Yagihashi , Psychotherapies and Psychological
Support for Individuals Facing Psychological Distressduring the COVID -19 Pandemic : A Scoping Review ,2023.9

4

Yudai Kaneda, Akihiko Ozaki, Michio Murakami, Hiroaki
Saito, Toyoaki Sawano, Erika Yamashiat, Kenji Gonda,
Kazunoshin Tachibana , Tohru Ohtake , Masaharu
Tsubokura, Hiromichi Ohira, Impact of large-scale disasters
on breast cancer care: A qualitative analysis of patient
experiences during the 2011 triple disaster in Fukushima,
Japan, 2023.12

39

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