研究業績（2010.4.1-12011.3.31）
英文原著
1.

Akishita M, Fukai S, Hashimoto M, Kameyama Y, Nomura K, Nakamura T, Ogawa
S, Iijima K, Eto M, Ouchi Y. Association of low testosterone with metabolic
syndrome and its components in middle-aged Japanese men. Hypertens Res. 33:
587-591, 2010.
2. Akishita M, Hashimoto M, Ohike Y, Ogawa S, Iijima K, Eto M, Ouchi Y. Low
testosterone level as a predictor of cardiovascular events in Japanese men withcoronary risk factors. Atherosclerosis. 210: 232-236, 2010.
3. Azuma K, Casey SC, Ito M, Urano T, Horie K, Ouchi Y, Kirchner S, Blumberg B,Inoue S. Pregnane X receptor knockout mice display osteopenia with reduced boneformation and enhanced bone resorption. J Endocrinol. 207: 257-263, 2010.
4. Fujita M, Sugama S, Sekiyama K, Sekigawa S, Tsukui T, Nakai M, Waragai M,Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, LaSpada AR, Masliah E, Inoue
S, Hashimoto M. Α β-synuclein mutation linked to dementia produces
neurodegeneration when expressed in mouse brain. Nat Commun. 1: 110, 2010.
5. Fukai S, Akishita M, Miyao M, Ishida K, Toba K, Ouchi Y. Age-related changes inplasma androgen levels and their association with cardiovascular risk factors inmale Japanese office workers. Geriatr Gerontol Int.10: 32-39, 2010.
6. Fukai S, Akishita M, Yamada S, Ogawa S, Yamaguchi K, Kozaki K, Toba K, Ouchi
Y. Plasma sex hormone levels and mortality in disabled older men and women.
Geriatr Gerontol Int. 11: 196-203, 2010.
7. Fukai S, Akishita M, Yamada S, Toba K, Ouchi Y. Effects of testosterone in oldermen with mild to moderate cognitive impairment. J Am Geriatr Soc. 58: 1419-21,2010.
8. Iijima K, Hashimoto H, Hashimoto M, Son BK, Ota H, Ogawa S, Eto M, Akishita
M, Ouchi Y. Aortic arch calcification detectable on chest X-ray is a strong
independent predictor of cardiovascular events beyond traditional risk factors.
Atherosclerosis. 210: 137-144, 2010.
9. Iwaoka Y, Hashimoto R, Koizumi H, Yu J, Okabe T. Selective stimulation bycinnamaldehyde of progesterone secretion in human adrenal cells. Life Sci. 86:894-898, 2010.
10. Koizumi H, Yu J, Hashimoto R, Ouchi Y, Okabe T. Involvement of androgen
receptor in nitric oxide production induced by icariin in human umbilical vein
endothelial cells. FEBS Lett. 584: 2440-2444, 2010.
11. Kurosawa T, Hiroi H, Momoeda M, Inoue S, Taketani Y. Clomiphene citrate elicits
estrogen agonistic/antagonistic effects differentially via estrogen receptors α and β.
Endocr J. 57: 517-521, 2010.
12. Murata T, Takayama K, Katayama S, Urano T, Horie-Inoue K, Ikeda K, Takahashi
S, Kawazu C, Hasegawa A, Ouchi Y, Homma Y, Hayashizaki Y, Inoue S. miR-148a
is an androgen-responsive microRNA that promotes LNCaP prostate cell growth byrepressing its target CAND1 expression. Prostate Cancer Prostatic Dis. 13:
356-361, 2010.
13. Nakajima Y, Osakabe A, Suzuki T, Kishimoto Y, Kuroda T, Fujimura T, Homma
Y, Murayama A, Inoue S, Yanagisawa J. KLF5-ERβ pathway is responsible for thecontradictory effects of estrogen on prostate tumor formation. Sci Signal. (in press)
14. Nomura K, Eto M, Kojima T, Ogawa S, Iijima K, Nakamura T, Araki A, Akishita M,Ouchi Y. Visceral fat accumulation and metabolic risk factor clustering in olderadults. J Am Geriatr Soc. 58: 1658-1663, 2010.
15. Onodera Y, Miki Y, Suzuki T, Takagi K, Akahira JI, Sakyu T, Watanabe M, Inoue
S, Ishida T, Ohuchi N, Sasano H. Runx2 in human breast carcinoma: its potential
roles in cancer progression. Cancer Sci. 101: 2670-2675, 2010.
16. Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi
Y. Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins
Inhibits Endothelial Senescence Through the Akt Pathway. Arterioscler Thromb
Vasc Biol. 30: 2205-2211, 2010.
17. Oyama M, Nagashima T, Suzuki T, Kozuka-Hata H, Yumoto N, Shiraishi Y, Ikeda
K, Kuroki Y, Gotoh N, Ishida T, Inoue S, Kitano H, Okada-Hatakeyama M.
Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome inTamoxifen-Resistant Breast Cancer. J Biol Chem. 286: 818-829, 2011.
18. Shigemoto K, Kubo S, Mori S,Yamada S, Akiyoshi T, Miyazaki T. Muscle
weakness and neuromuscular junctions in aging and disease. Geriatr Gerontol Int.
10: S137-147, 2010.
19. Son BK, Akishita M, Iijima K, Ogawa S, Maemura K, Yu J, Takeyama K, Kato S,Eto M, Ouchi Y. Androgen Receptor-dependent Transactivation of Growth
Arrest-specific Gene 6 Mediates Inhibitory Effects of Testosterone on Vascular
Calcification. J Biol Chem. 285: 7537-7544, 2010.
20. Takayama K, Tsutsumi S, Katayama S, Okayama T, Horie-Inoue K, Ikeda K, UranoT, Kawazu C, Hasegawa A, Ikeo K, Gojyobori T, Ouchi Y, Hayashizaki Y,Aburatani H, Inoue S. Integration of cap analysis of gene expression and chromatin
immunoprecipitation analysis on array reveals genome-wide androgen receptor
signaling in prostate cancer cells. Oncogene. 30: 619-630, 2011.
21. Urano T, Shiraki M, Usui T, Sasaki N, Ouchi Y, Inoue S. Identification ofnon-synonymous polymorphisms in the WDSOF1 gene as novel susceptibilitymarkers for low bone mineral density in Japanese postmenopausal women. Bone.
47: 636-642, 2010.
22. Urano T, Narusawa K, Sasaki N, Shiraki M, Hosoi T, Ouchi Y, Nakamura T, Inoue
S. A single-nucleotide polymorphism in the hyaluronan and proteoglycan linkprotein 1 (HAPLN1) gene is associated with spinal osteophyte formation and discdegeneration in Japanese women. Eur Spine J. 20: 572-577, 2011.
23. Urata Y, Goto S, Kawakatsu M, Yodoi J, Eto M, Akishita M, Kondo T. DHEA
attenuates PDGF-induced phenotypic proliferation of vascular smooth muscle A7r5cells through redox regulation. Biochem Biophys Res Commun. 396: 489-494,2010.

24. Yamada S, Akishita M, Fukai S, Ogawa S, Yamaguchi K, Matsuyama J, Kozaki K,Toba K, Ouchi Y. Effects of dehydroepiandrosterone supplementation on cognitive
function and ADL in older women with mild to moderate cognitive impairment.
Geriatr Gerontol Int. 10: 280-287, 2010.
25. Yu J, Akishita M, Eto M, Ogawa S, Son BK, Kato S, Ouchi Y, Okabe T. Androgen
receptor-dependent activation of endothelial nitric oxide synthase in vascularendothelial cells: role of phosphatidylinositol 3-kinase/akt pathway. Endocrinology.
151: 1822-1828, 2010.
英文症例報告1.

Fujimoto S, Yamaguchi Y, Gotanda H, Shiozawa R, Takemura A,
Umeda-Kameyama Y, Yamamoto H, Iijima K, Akishita M, Ouchi Y. A case oflimbic encephalitis with small cell lung carcinoma in which the cognitive function
improved and redeteriorated during tumor therapy. Nippon Ronen Igakkai Zasshi.
47: 79-85, 2010.
英文総説

1.

Akishita M. Strict vs. mild blood pressure control in the elderly. Hypertens Res. 33:1102-1103, 2010.
2. Iijima K, Akishita M, Ouchi Y. Coronary artery calcification and cerebral smallvessel disease. Circ J. 75: 272-273, 2011.
3. Ota H, Eto M, Ogawa S, Iijima K, Akishita M, Ouchi Y. SIRT1/eNOS Axis as a
Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis. JAtheroscler Thromb. 151: 1822-8, 2010.