The University of Tokyo
Faculty of Medicine
Graduate School of Medicine

PROSPECTUS
2009—2010

A Message From the Dean of Faculty and Graduate Schoolof Medicine, the University of Tokyo
Faculty of Medicine, the University of Tokyo was established in 1858, and in May of 2008 wecelebrated the 150th anniversary of our founding. University Executives, faculty members, staff,
and students came together for an impressive birthday ceremony, and a student-designed
monument was installed in front of our main building. To mark the occasion, we also decided
to renovate our clinical amphitheater and lecture rooms, to establish a museum of health andmedicine, and to start a new program of scholarships for students interested in research.
With its history and traditions in mind, we must move Faculty of Medicine, the University ofTokyo continuously forward. Each year in our Faculty, some 100 students begin medical school
and about 40 are admitted to School of Health Sciences and Nursing (which from 2010 onwards
we will call the “School of Integrated Health Sciences”). Also, through our highly competitive
PhD-MD program and the Medical Scientist Training Program that we began in 2008, several
outstanding medical students have already taken their first steps on the road to research careers.
Our graduate school has a wide range of programs of study, and we grant from 150 to 200 doctoral
degrees each year. Since its establishment in 2007, our new School of Public Health has admitted
many exceptional physicians and public health researchers. It is also noteworthy that many
students who enter our Master's degree program in the medical sciences after graduating with
Bachelor's degrees in fields other than medicine continue their studies in our doctoral programs.
We expect that medicine will be at the center of the rapidly advancing life sciences in the 21st
century. Furthermore, as we face the consequences of having an increasing number of elderly
people in our population, we know that integrated health sciences, preventive medicine,environmental medicine, and nursing will become increasingly important. We haveinternationally prominent teachers and researchers working in a wide variety of fields, andnumerous endowed departments that embody productive relations between academia andindustry.
Through our four Global Centers of Excellence (GCOE), we support financially graduate students
and collaborative research with other graduate schools. Among our international activities, weteach students mainly from Asia and southeast Asia but also from other regions, and we are
forging new ties with universities in Europe and North America.
Thus we are involved in a broad and growing spectrum of activities: investigating the humanbody in health and disease; promoting cross-disciplinary integration at the cutting edge of medical
research and education; improving methods of diagnosis, treatment, and acute and long-term
care; strengthening preventive medicine; improving hospital management and medical services
delivery; and communicating effectively in the wider social sphere.
In brief, we continue on our missions to provide the best possible medical care to patients inneed today and to train top-level research scientists who will lay the foundations of medicine
for tomorrow.

Takao Shimizu
Dean, Faculty and Graduate Schoolof Medicine
The University of Tokyo

HISTORY
1858

May

Practitioners, trained in Dutch (European) medicine in Edo (Tokyo), laid out money to establish the
Shutojo (vaccination center) in Kanda Mitamagaike.

Nov.

Shutojo was destroyed in a fire that had spread from Kanda Aioicho. Shutojo continued its operations at other sites such as the residence of Ito Genboku.

1859

Sep.

Shutojo was reconstructed at Shitaya Izumibashi Dohri.

1860

Oct.

Shutojo became an official medical institution of the Shogunate Government.

1861

Oct.

Shutojo was renamed as Seiyo Igaku-Sho (Institute of Western Medicine) and offered courses ofWestern Medicine in the fields of Education, Autopsy, and Vaccination.

1863

Feb.

Seiyo Igaku-Sho was renamed as Igaku-Sho (Institute of Medicine).

1868

Jul.

Igaku-Sho, affiliated with the Military Hospital which had been moved from Yokohama to Todo residence in Shitaya, was renamed as Daibyoin (the Great Hospital).

1869

Feb.

The Daibyoin was renamed as Igakko-Ken-Byoin (Medical School and Hospital).

Dec.

Igakko-Ken-Byoin was renamed as Daigaku–Toko (University East Building).

1871

Jul.

The Ministry of Education was established and Daigaku-Toko was renamed as Toko (East Building).

1872

Aug.

A School System was established. Toko was renamed as Daiichi-Daigaku-Ku- Igakko (The First
University District Medical School).

1874

May

Daiichi-Daigaku-Ku-Igakko was renamed as Tokyo-Igakko (Tokyo Medical School).

1876

Nov.

Tokyo-Igakko was moved to Hongo.

1877

Apr.

Tokyo Igakko, affiliated with Tokyo-Kaisei School, was renamed as The University of Tokyo. Tokyo
Medical School was renamed as The University of Tokyo Faculty of Medicine.

1886

Mar.

The University of Tokyo was renamed as Imperial University, and The University of Tokyo Faculty of
Medicine was renamed as the Imperial University Medical College. A Graduate School was established.

1897

Jun.

The Imperial University was renamed as Tokyo Imperial University.

1917

Aug.

Eiraku Hospital, affiliated with the Ministry of Education Medical Practice License Examination,
moved to Tokyo Imperial University and was renamed as Koishikawa Hospital affiliated with Tokyo
Imperial University Medical College.

1919

Apr.

A faculty system was established renaming Tokyo Imperial University Medical College as theFaculty of Medicine.

1931
1936

Feb.

The first building of the Faculty of Medicine was constructed.

Jan.

The Brain Research Laboratory was built with funds donated by Mr. Hisasaburo Horikoshi.

Nov.

The second building of the Faculty of Medicine (main building) was constructed.

1947

Oct.

Tokyo Imperial University was renamed as The University of Tokyo.

1950

Apr.

The Institute of Nursing was renamed as The University Nursing School.

1953

Apr.

The School of Health Care and Nursing was founded.

Jul.

The Graduate School was founded, and the Division of Medical Doctor Biological Science wasestablished. The Brain Research Laboratory became the Brain Research Institute of the Faculty of
Medicine.

1956
1958

2

Apr.

The Midwives School was established.

Apr.

The Division of Pharmaceutical Sciences became an independent faculty.

May

The University of Tokyo Faculty of Medicine celebrated its centennial anniversary.

1961
1965

Mar.

The Medical Library was built in commemoration of the centenary.

Apr.

The Institute of Medical Electronics was established.

Apr.

The Research Institute of Logopedics and Pediatrics was established. The School of Health Careand Nursing was reorganized as the School of Health Sciences. The Graduate School of The
University of Tokyo was reorganized and the Division of Medical Doctor Biological Science
became the Faculty of Medicine. The Health science Course was established in the Medical
Science Division.

1966

Sep.

The third building of the Faculty of Medicine was constructed.

1971

Apr.

The Laboratory of Animal Experiments was established.

1973

Mar.

The Animal Center for Biomedical Research was constructed.

1983

Jan.

An annex of the third building of the Faculty of Medicine was constructed.

1985

Sep.

The office of International Academic Affairs was established.

1987

Apr.

Specialized courses were introduced to the Graduate School of Medicine.

1992

Apr.

The School of Health Sciences became the School of Health Science and Nursing. The School ofInternational Health was established in the Medical Science Division.

1995

Jul.

The Radiation Research Institute was established.

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, four divisions, Third
Basic Medicine, Social Medicine, Third and Fourth Clinical Medicine, were replaced with
Pathology, Immunology and Microbiology, Social Medicine, Reproduction and Development, andAging Science and Surgery.

1996

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions, First
Clinical Medicine, Health Science, and International Health, were replaced with Internal Medicine,
Health Science and Nursing, and International Health.

1997

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions, Firstand Second Basic Medicine, and Second Clinical Medicine, were replaced with Molecular Cell
Biology, Functional Biology, Radiology and Biomedical Engineering, and Neuroscience.
As a result of the above-mentioned reorganization, three institutes, the Institute of Brain Research,
the Institute of Medical Electronics, and the Institute of Logopedics and Phoniatrics were maderedundant.

1999

Apr.

The Master course of Medical Science was established in the Graduate School of Medicine. This
course accepts graduates of all faculties except those from Schools of Medicine, Dentistry, andVeterinary Medicine.

2000

Apr.

The International Research Center for Medical Education was established (A shared facility for education and research).

2001

Apr.

The University Branch Hospital was united with the University Hospital.

2003

Apr.

The Center for Disease Biology and Integrative Medicine was established.

2004

Apr.

All the National Universities owned by the Japanese Government became National University
Corporations. and the University of Corporation.

2007

Apr.

The School of Public Health was established. This school offers programs for Master of Public
Health.

2008

May.

The University of Tokyo Faculty of Medicine and the University of Tokyo Hospital celebrated their150th anniversary.

3Graduate School of Medicine

Molecular
Cell Biology

Cell Biology and Anatomy･ Cell Biology ･ Structural Biology ･ Structural Cell Biology ･ Cellular Neurobiology
Biochemistry and Molecular Biology･ Molecular Biology ･ Cellular Signaling ･ Physiological Chemistry and Metabolism

Functional
Biology

Physiology･ Integrative Physiology ･ Cellular and Molecular Physiology ･ Neurophysiology
Pharmacology･ Cellular and Molecular Pharmacology ･ Molecular Neurobiology

Pathology, Immunology
and Microbiology

Pathology･ Pathology and Diagnostic Pathology ･ Molecular Pathology
Microbiology･ Microbiology ･ Infection Control and Prevention
Immunology･ Immunology

Radiology and Biomedical
Engineering

Radiology･ Diagnostic Radiology ･ Radiotherapy ･ Nuclear Medicine
Biomedical Engineering･ System Physiology ･ Bioimaging and Biomagnetics ･ Biosystem Construction and Control

Neuroscience

Basic Neuroscience･ Neuropathology ･ Neurochemistry ･ Neurobiology
Speech and Cognitive Sciences (2010.4~ Integrative Medical Neuroscience)･ Speech Science ･ Cognitive Neuroscience ･ Speech Physiology(2010.4~ ･ Developmental Neuroscience ･ Cognitive Neuroscience ･ Systems Medical Neuroscience ･ Child Neuropsychiatry)
Clinical Neuroscience･ Neuropsychiatry ･ Neurology ･ Neurosurgery

Social Medicine

Occupational, Environmental and Preventive Medicine･ Molecular Preventive Medicine ･ Public Health ･ Radiological HealthForensic Medicine, and Medical Informatics and Economics･ Forensic Medicine ･ Medical Informatics and Economics

Internal Medicine

Medicine I･ Cardiovascular Medicine ･ Vascular Biology ･ Respiratory Medicine ･ Gastroenterology ･ Nephrology
Medicine II･ Endocrinology ･ Nutrition and Metabolism ･ Hematology and Oncology ･ Allergy and Rheumatology･ Infectious Diseases ･ Stress Science and Psychosomatic Medicine
Clinical Laboratory Medicine and Pathology･ Clinical Laboratory Medicine ･ Transfusion Medicine

Reproductive,
Developmental andAging Sciences

Obstetrics and Gynecology･ Reproductive Endocrinology ･ Gynecological Oncology ･ Perinatal Medicine ･ Molecular Cellular Reproductive Medicine
Pediatric Sciences･ Pediatrics ･ Developmental Pediatrics ･ Pediatric Surgery ･ Pediatric Oncology
Aging Sciences･ Geriatrics ･ Aging Research

Surgical Sciences

Surgery･ Thoracic Surgery ･ Cardiovascular Surgery ･ Gastrointestinal Surgery･ Hepatobiliary Pancreatic Surgery ･ Urology ･ Artificial Organ and Transplantation Division･ Surgical Oncology ･ Vascular Surgery ･ Metabolic Care and Endocrine Surgery
Sensory and Motor System Medicine･ Dermatology ･ Plastic and Reconstructive Surgery ･ Oral and maxillofacial Surgery ･ Orthopaedic Surgery･ Ophthalmology ･ Otorhinolaryngology, and Head & Neck Surgery ･ Rehabilitation Medicine
Vital Care Medicine･ Anesthesiology ･ Emergency and Critical Care Medicine

Health Sciences
and Nursing

Health Sciences･ Health Sociology ･ Mental Health ･ Epidemiology and Preventive Health Sciences･ Social Gerontology ･ Health Promotion Sciences ･ Biostatistics ･ Biomedical Ethics
Preventive and Administrative Nursing･ Advanced Clinical Nursing ･ Nursing Administration ･ Family Nursing ･ Community Health Nursing ･ Public Health Nursing
Clinical Nursing･ Adult Nursing ･ Palliative Care Nursing ･ Midwifery and Women's Health･ Psychiatric Nursing ･ Gerontological Nursing ･ Wound Care Management

International HealthInternational Social Medicine･ Global Health Policy ･ Community and Global HealthInternational Biomedical Sciences･ Human Genetics ･ Developmental Medical Sciences ･ Human Ecology ･ Biomedical Chemistry

School of Public Health

Epidemiology and Health Sciences･ Biostatistics ･ Social and Preventive Epidemiology ･ Health Economics and Epidemiology Research･ Health Communication
Behavioral Health Sciences･ Mental Health ･ Health Sociology and Health Education ･ Social Gerontology･ Health Promotion Science ･ Biomedical Ethics
Health Services Sciences･ Health Policy ･ Healthcare Informatics ･ Clinical Information Engineering ･ Forensic Medicine and Medical Law

Center for Disease
Biology andIntegrative Medicine･ Laboratory of Molecular Biomedicine for Pathogenesis ･ Laboratory of Structural Physiology ･ Laboratory ofRegenerative Medical Engineering ･ Laboratory of Clinical Biotechnology ･ Laboratory of Environmental Health Sciences･ Laboratory of Animal Resources ･ Laboratory of Molecular Radiology ･ Divisions of Research Resources and Support(Section of Animal Research, Section of Radiation Biology, Section of Bioinfomatics)

4

Endowed Department･ Pharmacoepidemiology ･ Integrated Traditional Medicine (Tsumura) ･ Vascular Regeneration (Daiichi
Sankyo Co.,Ltd) ･ Bone & Cartilage Regenerative Medicine ･ Cartilage & Bone Regeneration (Fujisoft)･ Clinical Renal Regeneration ･ Metabolome ･ Clinical Molecular Epidemiology (Mitsubishi Tanabe Pharma
Corporation) ･ Immunotherapeutics (Medinet) ･ Total Renal Care Medicine ･ Integrated Molecular
Science on Metabolic Diseases ･ Advanced Clinical Science and Therapeutics ･ Kaatsu Training･ Translational Research for Healthcare and Clinical Science ･ Joint Disease Research ･ Health CareManagement and Policy ･ Computational Diagnostic Radiology and Preventive Medicine･ Hospital Environment ･ Clinical Motor System Medicine ･ Medical Safety Management (Tokio Marine &Nichido) ･ Molecular Cardiovascular Metabolism ･ Healthcare Quality Assessment ･ Anti-Aging Medicine･ Integrated Imaging Informatics ･ Nutriproteomics ･ Clinical Epidemiology and Systems･ Clinical Trial Data Management ･ Pharmacology and Pharmacokinetics ･ Ubiquitous Preventive Medicine･ Science for Joint Reconstruction ･ Molecular Research for Vascular Diseases ･ Advanced Skin Care(Miss Paris) ･ Therapeutic Strategy for Heart Failure ･ Molecular Physiology on Energy Metabolism･ Molecular Neuroscience on Neurodegeneration ･ Chronic Kidney Disease ･ Molecular Structure andDynamics (JEOL/Zeiss) ･ Molecular Vascular Endocrinology ･ Medical Genomics

Special Coordination
Funds for Promoting
Science and Technology･ Translational Systems Biology and Medicine Initiative

Global COE･ Integrative Life Science Based on the Study of Biosignaling Mechanisms･ Comprehensive Center of Education and Research for Chemical Biology of the Diseases･ Creation of a New Interdisciplinary and International Base for Biomedical Ethics Education and Research･ Medical System Innovation through Multidisciplinary Integration

Social Cooperation
Program･ Ubiquitous Health Informatics

Special Education
Research Project･ Child Psychiatry Clinical Education Frontier project

Coordination, Support
and Training Program forTranslational Research･ Organization of the Center for Supporting Innovative Medicine and Execution of Translational ResearchInstitution･ International Academic Affairs ･ Medical Library ･ Medical Scientist Training Program･ Cancer Genomics Project

Faculty of Medicine
School of Medicine･ Cell Biology and Anatomy ･ Biochemistry and Molecular Biology ･ Physiology ･ Pharmacology･ Pathology ･ Microbiology ･ Immunology ･ Radiology ･ Biomedical Engineering ･ Basic Neuroscience･ Speech and Cognitive Sciences ･ Clinical Neuroscience･ Occupational, Environmental and Preventive Medicine ･ Medical Principles and Medical Ethics･ Forensic Medicine, and Medical Informatics and Economics ･ Medicine I ･ Medicine II･ Clinincal Laboratory Medicine and Pathology ･ Obstetrics and Gynecology ･ Pediatric Science･ Aging Science ･ Sugery ･ Sensory and Motor System Medicine ･ Vital Care Medicine

School of Health
Sciences and Nursing･ Family Nursing ･ Community Health Nursing ･ Fundamental Nursing ･ Adult Health and Nursing･ Mental Health and Nursing Health Sociology ･ Health Administration ･ Epidemiology and Biostatistics･ Human Ecology ･ Biochemistry and Nutrition ･ Maternal and Child Health(2010.4 - School ofIntegrated Health Sciences)

University Hospital
Clinical DivisionInternal Medicine ･ General Medicine ･ Cardiovascular Medicine ･ Respiratory Medicine ･ Gastroenterology･ Nephrology and Endocrinology ･ Metabolic Diseases ･ Hematology and Oncology ･ Allergy andRheumatology ･ Infectious Diseases ･ Neurology ･ Geriatric Medicine ･ Psychosomatic Medicine
Surgery･ General Surgery ･ Stomach and Esophageal Surgery ･ Colon and Rectal Surgery ･ Hepatobiliary
Pancreatic Surgery ･ Vascular Surgery ･ Breast and Endocrine Surgery ･ Artificial Organ andTransplantation Surgery ･ Cardiovascular Surgery ･ Thoracic Surgery ･ Neurosurgery･ Anesthesiology and Pain Relief Center ･ Urology and Andrology ･ Gynecologic Surgery
Sensory and Motor System Medicine ･ Dermatology and Photolaser Medicine ･ Ophthalmology and Vision
Correction ･ Orthopaedic Surgery and Spinal Surgery ･ Otorhinolaryngology, and Auditory andVoice Surgery ･ Rehabilitation Medicine ･ Plastic, Reconstructive, and Aesthetic Surgery･ Oral-Maxillofacial Surgery, Dentistry and Orthodontics
Pediatrics, Perinatal and Women's Medicine ･ Pediatrics ･ Pediatric Surgery ･ Obstetrics and Gynecology
Neuropsychiatry ･ NeuropsychiatryRadiology ･ Radiology

Central Clinical Facilities･ Pharmaceutical Services ･ Clinical Laboratory ･ Surgical Center ･ Radiological Center ･ Emergency Services･ Transfusion Medicine and Immunohematology ･ Maternal, Fetal, and Neonatal Medicine ･ Rehabilitation
Service ･ Central Supply Service ･ Medical Engineering ･ Intensive Care Unit ･ Pathology ･ Corneal
Transplantation ･ University Hospital Medical Information Network Center ･ Cell Therapy and Transplantation
Medicine ･ Infection Control and Prevention ･ Endoscopy and Endoscopic Surgery ･ Hemodialysis andApheresis ･ Clinical Research Center ･ Medical Community Network ･ Planning, Information andManagement ･ Organ Transplantation Service ･ Nursing ･ Nutrition ･ Labor Safety and Health Management
Office ･ Child Psychiatry ･ Tissue Bank ･ Epidemiology and Preventive Medicine ･ Cancer Patient Support
Center ･ Center for Liaison and Public Relations ･ Database Center of the National University Hospitals･ Outpatient Chemotherapy ･ Neonatal and Pediatric Intensive Care Unit ･ Tissue Engineering ･ Clinical andGenetic Informatics ･ Palliative Medicine ･ Clinical Genomics ･ Cooperative Unit of Medicine andEngineering Research ･ Medical Specialists Training CenterTranslational Research Center
22nd Century Medical and Research Center
Administration Office

Center･ The International Research Center for Medical Education

Administrative Division･ General Affairs Office ･ Personnel Office ･ Research Liaison ･ Educational Affairs･ Graduate Student Affairs ･ Buget Office ･ Purchasing Office ･ Finance Office･ Facilities Office ･ Reception Service Medical Library･ Administration Office Medical Library ･ Information Service Medical Library5Graduate School of Medicine
As of Nov. 1, 2009

A
G
C
T

Dean

P14

Molecular Cell
Biology

Takao Shimizu

Immunology
Department of Immunology*
Professor
Tadatsugu Taniguchi

Cell Biology and Anatomy*
Department of Cell Biology
Associate Professor Yosuke Takei
Department of Structural Biology
Professor
Masahide Kikkawa
Department of Structural Cell Biology
Associate Professor Yoshimitsu Kanai

Radiology andBiomedical
Engineering

P22

Radiology*

Department of Cellular Neurobiology
Professor
Shigeo Okabe

Department of Diagnostic Radiology
Professor
Kuni Ohtomo
Associate Professor Osamu Abe

Biochemistry and Molecular Biology

Department of Radiotherapy
Associate Professor Keiichi Nakagawa

Department of Molecular Biology*
Professor
Hiroto Okayama
Associate Professor Shigeki Jinno

Department of Nuclear Medicine
Associate Professor Toshimitsu Momose

Department of Cellular Signaling*
Professor
Takao Shimizu
Associate Professor Motonao Nakamura
Associate Professor Satoshi Ishii

Biomedical Engineering

Department of Physiological Chemistry and Metabolism*
Professor
Hiroki Kurihara

Department of Biosystem Construction and Control*
Associate Professor Yusuke Abe

Functional Biology

P18

Department of System Physiology*
Department of Bioimaging and Biomagnetics

Neuroscience

P24

Physiology

Basic Neuroscience

Department of Integrative Physiology*
Professor
Yasushi Miyashita
Associate Professor Seiki Konishi

Department of Neuropathology*
Professor
Takeshi Iwatsubo

Department of Cellular and Molecular Physiology*
Professor
Kensaku Mori
Department of Neurophysiology*
Professor
Masanobu Kano
Associate Professor Kouichi Hashimoto

Pharmacology
Department of Cellular and Molecular Pharmacology*
Professor
Masamitsu Iino
Department of Molecular Neurobiology*
Professor
Masayoshi Mishina

Department of Neurochemistry*
Associate Professor Haruhiko Bito
Department of Neurobiology
Professor
Kenzo Hirose

Speech and Cognitive Sciences(2010.4~ Integrative Medical Neuroscience)
Department of Speech Science(2010.4~ Department of Developmental Neuroscience)
Department of Cognitive Neuroscience*(2010.4~ Department of Cognitive Neuroscience)
Associate Professor Katsuyuki Sakai
Department of Speech Physiology(2010.4~ Department of Systems Medical Neuroscience)

Pathology,
Immunology andMicrobiology

P20

Pathology
Department of Pathology and Diagnostic Pathology*
Professor
Masashi Fukayama
Department of Molecular Pathology*
Professor
Kohei Miyazono
Associate Professor Tetsuro Watabe

Microbiology
Department of Microbiology*
Professor
Masanori Hatakeyama
Department of Infection Control and Prevention*
Professor
Kyoji Moriya

6* Introduction to lab included(2010.4~ Department of Child Neuropsychiatry)

Clinical Neuroscience
Department of Neuropsychiatry*
Professor
Kiyoto Kasai
Associate Professor Nobuo Nakayasu
Associate Professor Hidenori Yamasue
Department of Neurology*
Professor
Shoji Tsuji
Associate Professor Shin Kwak
Department of Neurosurgery*
Professor
Nobuhito Saito
Associate Professor Kensuke KawaiSocial Medicine

P28

Occupational, Environmental andPreventive Medicine
Department of Molecular Preventive Medicine*
Professor
Kouji Matsushima
Associate Professor Sho Ishikawa-Yamawaki
Department of Public Health*Professor
Yasuki Kobayashi
Associate Professor Takahiro Higashi

Reproductive,
Developmental andAging Sciences

P34

Obstetrics and Gynecology and Gynecology
Department of Reproductive Endocrinology*
Professor
Yuji Taketani
Associate Professor Tomoyuki Fujii
Department of Gynecological Oncology*
Associate Professor Tetsu Yano
Department of Perinatal Medicine*

Department of Radiological Health

Department of Molecular Cellular Reproductive Medicine*
Professor
Shiro Kozuma

Forensic Medicine, and Medical Informatics andEconomics

Pediatric Sciences

Department of Forensic Medicine*
Professor
Ken-ichi Yoshida
Department of Medical Informatics and Economics*
Professor
Kazuhiko Ohe

Internal Medicine

P30

Department of Pediatrics*
Professor
Takashi Igarashi
Associate Professor Akira Kikuchi
Department of Developmental Pediatrics*
Professor
Takashi Igarashi
Associate Professor Sachiko Kitanaka
Department of Pediatric Surgery*
Professor
Tadashi Iwanaka
Associate Professor Yutaka Kanamori

Medicine I

Department of Pediatric Oncology*
Professor
Tadashi Iwanaka

Department of Cardiovascular Medicine*
Professor
Ryozo Nagai

Aging Sciences

Department of Vascular Biology
Department of Respiratory Medicine*
Professor
Takahide Nagase
Department of Gastroenterology*
Professor
Kazuhiko Koike

Department of Geriatrics*
Professor
Yasuyoshi Ouchi
Associate Professor Masahiro Akishita
Department of Aging Research
Professor
Yasuyoshi Ouchi

Department of Nephrology*

Surgical Sciences

Medicine II
Department of Endocrinology*
Professor
Toshiro Fujita
Department of Nutrition and Metabolism*
Professor
Takashi Kadowaki
Associate Professor

Kohjiro Ueki

Department of Hematology and Oncology*
Professor
Mineo Kurokawa
Department of Allergy and Rheumatology*
Professor
Kazuhiko Yamamoto
Department of Infectious Diseases*
Associate Professor Hiroshi Yotsuyanagi
Department of Stress Science and Psychosomatic Medicine*
Professor
Akira Akabayashi
Associate Professor Kazuhiro Yoshiuchi

Clinical Laboratory Medicine and Pathology

P38

Surgery
Department of Thoracic Surgery*
Associate Professor Jun Nakajima
Department of Cardiovascular Surgery*
Professor
Minoru Ono
Associate Professor Arata Murakami
Department of Gastrointestinal Surgery*
Professor
Yasuyuki Seto
Associate Professor Sachiyo Nomura
Department of Hepatobiliary Pancreatic Surgery*
Professor
Norihiro Kokudo
Associate Professor Kiyoshi Hasegawa
Department of Urology*
Professor
Yukio Honma
Associate Professor Haruki Kume

Department of Clinical Laboratory Medicine*
Professor
Yutaka Yatomi
Associate Professor Hitoshi Ikeda

Department of Artificial Organ and Transplantation Division*
Associate Professor Yasuhiko Sugawara

Department of Transfusion Medicine*
Professor
Koki Takahashi

Department of Surgical Oncology*
Professor
Hirokazu Nagawa
Associate Professor Joji Kitayama
Department of Vascular Surgery*
Professor
Hirokazu Nagawa
Associate Professor Tetsuro Miyata
Department of Metabolic Care and Endocrine Surgery*
Associate Professor Toshihisa Ogawa

7

Sensory and Motor System Medicine

Clinical Nursing

Department of Dermatology*
Professor
Shinichi Sato
Associate Professor Kanako Kikuchi

Department of Adult Nursing*
Professor
Keiko Kazuma

Department of Plastic and Reconstructive Surgery*
Professor
Isao Koshima
Department of Oral and Maxillofacial Surgery*
Professor
Tsuyoshi Takato
Associate Professor Takafumi Susami
Associate Professor Yoshiyuki Mori
Department of Orthopaedic Surgery*
Professor
Kozo Nakamura
Associate Professor Hiroshi Kawaguchi
Associate Professor Sakae Tanaka

Department of Palliative Care Nursing*
Professor
Keiko Kazuma
Department of Midwifery and Women's Health*
Department of Psychiatric Nursing*
Professor
Norito Kawakami
Department of Gerontological Nursing*
Professor
Hiromi Sanada
Department of Wound Care Management*
Professor
Hiromi Sanada

Department of Ophthalmology*
Professor
Makoto Araie
Associate Professor Satoshi Kato
Associate Professor Yasuhiro Tamaki
Department of Otorhinolaryngology and Head & Neck Surgery*
Professor
Tatsuya Yamasoba
Associate Professor Shinichi Iwasaki
Associate Professor Takahiro Asakage
Department of Rehabilitation Medicine*
Professor
Nobuhiko Haga

Vital Care Medicine
Department of Anesthesiology*
Professor
Yoshitsugu Yamada
Department of Emergency and Critical Care Medicine*
Professor
Naoki Yahagi

Health Sciences
and Nursing

P44

Health Sciences
Department of Health Sociology*
Associate Professor Yoshihiko Yamazaki
Department of Mental Health*Professor
Norito Kawakami
Associate Professor Akihito Shimazu

International
HealthP50

International Social Medicine
Department of Global Health Policy*
Professor
Kenji Shibuya
Associate Professor Rintaro Mori
Department of Community and Global Health*Professor
Masamine Jimba

International Biomedical Sciences
Department of Human Genetics*
Professor
Katsushi Tokunaga
Associate Professor Akihiko Mabuchi
Department of Developmental Medical Sciences*
Professor
Masashi Mizuguchi
Associate Professor Teruyuki Tanaka
Department of Human Ecology*
Professor
Chiho Watanabe
Associate Professor Masahiro Umezaki
Department of Biomedical Chemistry*
Professor
Kiyoshi Kita
Associate Professor Yoh-ichi Watanabe

School of Public
HealthDepartment of Epidemiology and Preventive Health Sciences*
Professor
Yasuo Ohashi

P54

Department of Social Gerontology*
Professor
Ichiro Kai

Epidemiology and Health Sciences

Department of Health Promotion Sciences*
Associate Professor Jung Su Lee

Department of Biostatistics
Professor
Yasuo Ohashi
Associate Professor Yutaka Matsuyama

Department of Biostatistics*
Associate Professor Yutaka Matsuyama
Department of Biomedical Ethics*
Professor
Akira Akabayashi

Preventive and Administrative Nursing
Department of Advanced Clinical Nursing*
Professor
Katsuya Kanda
Department of Nursing Administration*
Professor
Katsuya Kanda
Department of Family Nursing*
Associate Professor Kiyoko Kamibeppu
Department of Community Health Nursing*
Professor
Sachiyo Murashima
Department of Public Health Nursing

8* Introduction to lab included

Department of Social and Preventive Epidemiology*
Professor
Satoshi Sasaki
Department of Health Economics and Epidemiology Research*
Professor
Hideki Hashimoto
Associate Professor Takashi Fukuda
Department of Health Communication
Professor

Takahiro Kiuchi

Behavioral Health Sciences
Department of Mental HealthProfessor
Norito Kawakami
Associate Professor Akihito Shimazu
Department of Health Sociology and Health Education
Associate Professor Yoshihiko Yamazaki
Department of Social Gerontology
Professor
Ichiro Kai
Department of Health Promotion Science
Associate Professor Jung Su Lee
Department of Biomedical Ethics
Professor
Akira Akabayashi

Department of Cartilage & Bone Regeneration (Fujisoft)
Associate Professor

Kazuto Hoshi

Department of Clinical Renal Regeneration
Associate Professor

Keiichi Hishikawa

Department of Metabolome
Professor
Associate Professor

Ryo Taguchi
Yoshiya Oda

Clinical Molecular Epidemiology (Mitsubishi Tanabe Pharma
Corporation)
Associate Professor

Takanari Gotoda

Immunotherapeutics (Medinet)
Associate Professor

Kazuhiro Kakimi

Division of Total Renal Care Medicine
Associate Professor

Akira Ishikawa

Integrated Molecular Science on Metabolic Diseases
Associate Professor

Toshimasa Yamauchi

Health Services Sciences

Department of Advanced Clinical Science and Therapeutics

Department of Health Policy
Professor
Yasuki Kobayashi
Associate Professor Takahiro Higashi

Associate Professor
Associate Professor

Department of Healthcare Informatics
Professor
Kazuhiko Ohe

Junichi Suzuki
Yasunobu Hirata

Kaatsu Training
Associate Professor

Toshiaki Nakajima

Translational Research for Healthcare and Clinical Science
Associate Professor

Hiroyuki Morita

Department of Clinical Information Engineering*
Professor
Hiroshi Oyama

Department of Joint Disease Research

Department of Forensic Medicine and Medical Law
Professor
Ken-ichi Yoshida

Health Care Management and Policy

Associate Professor
Associate Professor

Noriko Yoshimura
Hideo Yasunaga

Computational Diagnostic Radiology and Preventive Medicine

Center for Disease
Biology andIntegrative Medicine

P56

Associate Professor
Associate Professor

Hospital Environment
Associate Professor
Associate Professor

Professor

Professor

Laboratory of Structural Physiology*
Professor

Haruo Kasai

Yushi Uetera

Clinical Motor System Medicine

Director
Masayoshi Mishina
Laboratory of Molecular Biomedicine for Pathogenesis*
Toru Miyazaki

Naoto Hayashi
Kansei Uno

Toru Akune

Medical Safety Management (Tokio Marine & Nichido)
Yasushi Kodama

Molecular Cardiovascular Metabolism
Associate Professor

Katsuyuki Ando

Associate Professor Masanori Matsuzaki
Laboratory of Regenerative Medical Engineering*

Department of Healthcare Quality Assessment

Professor
Associate Professor

Anti-Aging Medicine

Takashi Ushida
Taichi Ito

Associate Professor
Professor

Hiroaki Miyata
Satoshi Inoue

Laboratory of Clinical Biotechnology*

Integrated Imaging Informatics

Professor
Associate Professor

Department of Nutriproteomics

Kazunori Kataoka
Nobuhiro Nishiyama

Laboratory of Environmental Health Sciences*
Professor
Associate Professor

Chiharu Tohyama
Seiichiroh Ohsako

Laboratory of Animal Resources*
Professor

Atsu Aiba

Laboratory of Molecular Radiology*
Professor

Kiyoshi Miyagawa

Divisions of Research Resources and Support *(Section of Animal Research)(Section of Radiation Biology)(Section of Bioinfomatics)

Associate Professor
Professor

Naoki Yoshioka
Kazumi Yagasaki

Clinical Epidemiology and Systems
Professor
Associate Professor

Tsutomu Yamazaki
Daisuke Koide

Clinical Trial Data Management
Associate Professor

Takuhiro Yamaguchi

Pharmacology and Pharmacokinetics
Associate Professor

Akihiro Hisaka

Ubiquitous Preventive Medicine
Associate Professor

Toru Suzuki

Science for Joint Reconstruction
Professor
Associate Professor

Yoshio Takatori
Toru Moro

Molecular Research for Vascular Diseases
Associate Professor

EndowedDepartment

Daisuke Nagata

Advanced Skin Care
Professor

Miss Paris

Junko Sugama

Therapeutic Strategy for Heart Failure
Pharmacoepidemiology
professor

Kiyoshi Kubota

Department of Integrated Traditional Medicine (Tsumura)
Associate Professor

Tetsuro Okabe

Department of Vascular Regeneration (Daiichi Sankyo Co., Ltd.)
Associate Professor

Hiroyuki Koyama

Department of Bone & Cartilage Regenerative Medicine
Associate Professor

Naofumi Ogata

Professor
Associate Professor

Shunei Kyo
Satoshi Gojo

Molecular Physiology on Energy Metabolism
Associate Professor

Naoya Yahagi

Molecular Neuroscience on Neurodegeneration
Associate Professor

Atsushi Iwata

Chronic Kidney Disease
Associate Professor

Miki Nagase

9Molecular Structure and Dynamics (JEOL / Zeiss)
Molecular Vascular Endocrinology
Associate Professor

Faculty of Medicine

Masashi Isshiki

Department of Medical Genomics
Professor
Hiroyuki Mano
Associate Professor CHOI Young Lim

Dean

P59

University
Hospital
Director

Takao Shimizu

Yuji Taketani

Special Coordination
Funds for Promoting
Science and Technology

Clinical Division (Department of Internal Medicine)Translational Systems Biology and Medicine Initiative

Professor
Shoji Tsuji
Cardiovascular Medicine

Associate Professor

Naoto Kubota

General Medicine

Professor

Ryozo Nagai

Respiratory Medicine
Professor

Takahide Nagase

Gastroenterology

Global COE

Professor

Kazuhiko Koike

Nephrology and Endocrinology
Professor

Integrative Life Science Based on the Study of Biosignaling
Mechanisms
Comprehensive Center of Education and Research for Chemical
Biology of the Diseases
Associate Professor
Associate Professor

Iciro Manabe
Hiroshi Kawasaki

Toshiro Fujita

Metabolic Diseases
Professor
Associate Professor

Takashi Kadowaki
Kojiro Ueki

Hematology and Oncology
Professor
Mineo Kurokawa
Allergy and Rheumatology

Professor
Kazuhiko Yamamoto
Creation of a New Interdisciplinary and International Base for
Biomedical Ethics Education and Research
Infectious Diseases
Kyoji Moriya
Medical System Innovation through Multidisciplinary Integration Professor
Associate Professor

Keiji Itaka

Associate Professor

Hiroshi Yotsuyanagi

Neurology
Professor
Associate Professor

Shoji Tsuji
Shin Kwak

SocialCooperation
ProgramGeriatric Medicine

Department of Ubiquitous Health Informatics
Associate Professor Hideo Fujita

Psychosomatic Medicine

Professor
Associate Professor
Professor
Associate Professor

Yasuyoshi Ouchi
Masahiro Akishita
Akira Akabayashi
Kazuhiro Yoshiuchi

Clinical Division (Department of Surgery)Special Education
Research Project

General Surgery
Professor
Professor

Child Psychiatry Clinical Education Frontier project
Associate Professor Yukiko Kano
Cancer Genomics Project
Associate Professor Seishi Ogawa

Hirokazu Nagawa

Stomach and Esophageal Surgery
Yasuyuki Seto

Associate Professor Sachiyo Nomura
Colon and Rectal Surgery
Professor
Associate Professor

Hirokazu Nagawa
Joji Kitayama

Hepatobiliary Pancreatic Surgery
Professor
Associate Professor

Coordination, Support
and Training Program forTranslational Research
Organization of the Center for Supporting Innovative Medicine
and Execution of Translational Research
Professor
Tomoki Todo
Associate Professor Yasushi Ino

Norihiro Kokudo
Kiyoshi Hasegawa

Vascular Surgery
Associate Professor

Tetsuro Miyata

Breast and Endocrine Surgery
Associate Professor Toshihisa Ogawa
Artificial Organ and Transplantation Surgery
Professor
Norihiro Kokudo
Associate Professor

Yasuhiko Sugawara

Cardiovascular Surgery
Professor
Associate Professor

Institution

Thoracic Surgery
Associate Professor

Office of International Academic Affairs
Head

Tatsuya Yamasoba

Medical Library
Head

Kazuhiko Ohe

Medical Scientist Training Program
Head

Shigeo Okabe* Introduction to lab included

Jun Nakajima

Neurosurgery
Professor

Nobuhito Saito

Associate Professor

Kensuke Kawai

Anesthesiology and Pain Relief Center
Professor
Yoshitsugu Yamada
Urology and Andrology
Professor
Associate Professor

Yukio Honma
Haruki Kume

Gynecologic Surgery
Associate Professor

10

Minoru Ono
Arata Murakami

Tetsu Yano

Clinical Division (Department of Sensory and Motor
System Medicine)
Dermatology and Photolaser Medicine
Professor
Associate Professor

Shinichi Sato
Kanako Kikuchi

Ophthalmology and Vision Correction

Department of Rehabilitation Service
Professor
Nobuhiko Haga
Department of Medical Engineering
Central Supply Service
Associate Professor Yoshikazu Mimura
Associate Professor

Kazuhiko Fukatsu

Department of Intensive Care Unit

Professor
Associate Professor
Associate Professor

Makoto Araie
Yasuhiro Tamaki

Satoshi Kato
Orthopaedic Surgery and Spinal Surgery

Department of Diagnostic Pathology

Professor
Associate Professor
Associate Professor

Kozo Nakamura
Hiroshi Kawaguchi
Sakae Tanaka

Department of Corneal Transplantation

Otorhinolaryngology, and Auditory and Voice Surgery
Professor
Tatsuya Yamasoba
Associate Professor
Associate Professor

Shinichi Iwasaki
Takahiro Asakage

Rehabilitation Medicine
Professor
Nobuhiko Haga
Plastic, Reconstructive and Aesthetic Surgery
Professor

Isao Koshima

Oral-Maxillofacial Surgery, Dentistry and Orthodontics
Professor
Associate Professor
Associate Professor

Tsuyoshi Takato
Takafumi Susami
Yoshiyuki Mori

Clinical Division (Department of Pediatrics, Perinatal
and Women's Medicine)
Pediatrics
Professor
Associate Professor
Associate Professor

Takashi Igarashi
Sachiko Kitanaka
Akira Kikuchi

Pediatric Surgery
Professor
Tadashi Iwanaka
Associate Professor

Yutaka Kanamori

Obstetrics and Gynecology
Professor

Shiro Kozuma

Associate Professor

Tomoyuki Fujii

Clinical Division (Department of Neuropsychiatry)
Neuropsychiatry
Professor
Associate Professor
Associate Professor

Kiyoto Kasai
Nobuo Nakayasu
Hidenori Yamasue

Cinical Division (Department of Radiology)
Radiology
Professor
Associate Professor
Associate Professor
Associate Professor

Kuni Ohtomo
Keiichi Nakagawa
Toshimitsu Momose
Osamu Abe

Central Clinical Facilities
Pharmaceutical Services*
Professor
Associate Professor

Hiroshi Suzuki
Kousei Ito

Clinical Laboratory*
Director
Vice Director

Yutaka Yatomi
Hitoshi Ikeda

Department of Surgical Center*
Professor
Associate Professor
Associate Professor

Hiroshi Yasuhara
Yoshikazu Mimura
Kazuhiko Fukatsu

Department of Radiological Center
Professor and Director
Associate Professor

Kuni Ohtomo
Masaaki Akabane

Department of Emergency Services
Professor

Naoki Yahagi

Department of Transfusion Medicine and Immunohematology
Professor

Koki Takahashi

Professor
Professor
Associate Professor

Naoki Yahagi
Masashi Fukayama
Shiro Amano

University Hospital Medical Information Network Center*
Professor

Takahiro Kiuchi

Department of Cell Therapy and Transplantation Medicine
Professor

Mineo Kurokawa

Department of Infection Control and Prevention
Professor

Kyoji Moriya

Department of Endoscopy and Endoscopic Surgery
Associate Professor

Mitsuhiro Fujishiro

Department of Hemodialysis and Apheresis
Professor
Associate Professor

Toshiro Fujita
Eisei Noiri

Clinical Research Center
Professor
Associate Professor

Takashi Kadowaki
Yoshihiro Arakawa

Department of Medical Social Community Network
Professor

Yasuyoshi Ouchi

Department of Planning, Information and Management
Professor
Associate Professor

Kazuhiko Ohe
Soichi Koike

Department of Organ Transplantation Service
Professor
Norihiro Kokudo
Associate Professor Yasuhiko Sugawara
Nursing Depertment
Department of Nutrition
Labor Safety and Health Management Office
Professor
Kiyoshi Kitamura
Department of Child Psychiatry
Professor
Takashi Igarashi
Associate Professor Yukiko Kano
Tissue Bank
Center for Epidemiology and Preventive Medicine
Professor
Tsutomu Yamazaki
Cancer Patient Support Center
Center for Liaison and Public Relations
Professor
Kazuhiko Ohe
Database Center of the National University Hospital
Department of Outpatient Chemotherapy
Professor
Norihiro Kokudo
Neonatal and Pediatric Intensive Care Unit
Associate Professor Arata Murakami
Division of Tissue Engineering
Professor
Tsuyoshi Takato
Department of Clinical and Genetic Informatics
Professor
Ryozo Nagai
Professor
Takashi Kadowaki
Department of Palliative Medicine
Associate Professor Keiichi Nakagawa
Department of Clinical Genomics
Professor
Shoji Tsuji
Cooperative Unit of Medicine and Engineering Research
Associate Professor Tetsuro Miyata
Associate Professor Hiroyuki Koyama
Medical Specialists Training Center
Associate Professor Nobuyuki Shimizu

Department of Maternal, Fetal, and Neonatal Medicine
Professor

Shiro Kozuma

11Translational Research Center
Professor
Professor

Ryozo Nagai
Tomoki Todo

22nd Century Medical and Research Center
Professor

Kozo Nakamura

Administration Office

CenterP62

The International Research Center for Medical Education*
Director
Professor

12

Kazuhiko Yamamoto
Kiyoshi Kitamura* Introduction to lab included

Faculty of Medicine
Graduate School of Medicine
The University of Tokyo

Graduate School of Medicine

Molecular Cell Biology...............................................14
Functional Biology .....................................................18
Pathology, Immunology and Microbiology ....................20
Radiology and Biomedical Engineering ........................22
Neuroscience ...........................................................24
Social Medicine ........................................................28
Internal Medicine .....................................................30
Reproductive, Developmental and Aging Sciences ........34
Surgical Sciences .....................................................38
Health Sciences and Nursing .....................................44
International Health ..................................................50
School of Public Health .............................................54
Center for Disease Biology and Integrative Medicine .....56
University Hospital

Pharmacy .................................................................59
Central Clinical Facilities ............................................60
CenterThe International Research Center for Medical Education
and Research .............................................................62

13

1

A
G
C
T

Molecular Cell Biology

Cell Biology and Anatomy ——————————————————————————————————————
http://cb.m.u-tokyo.ac.jp/

Cells transport various kinds of proteins, lipids and mRNAs after synthesis to their specific destinations such as several types of membranousorganelles, protein complexes and the mRNA complex. Thus, intracellulartransport is fundamental to cellular functions, survival and morphogenesis. Our laboratory is studying the mechanisms of intracellular transportand cellular morphogenesis, especially focusing on molecular motors,
Kinesin superfamily proteins (KIFs) and microtubule associated proteins(MAPs) using molecular cell biology, biophysics, structural biology, andmolecular genetics.

• Molecular cell biological study of KIFs
• Studies of the mechanism for recognition of and binding to cargoes by KIFs and theregulation of this mechanism• Studies of the mechanisms of differential directional transports and sorting• Studies of the dynamics and mechanism of motility of KIFs using molecular biophysics and structural biology• Molecular genetics of KIFs
• Studies of KIFs and related diseases• Molecular cell biology and molecular genetics of MAPs

Quick freeze-deep etch electron micrographof a mouse nerve axon showing a microtubule (25 nm diameter, linear tube-likestructure) and a cross-bridge linking the
microtubule and a membranous organelle.
Microtubules are a major component of thecytoskeleton and serve as a type of railalong which motor proteins transportorganelles inside cells. (Reproduced fromthe cover of Science vol. 279, Jan 23 1998.)

Structural Biology ————————————————————————————————————————————
http://structure.m.u-tokyo.ac.jp/

Kikkawa lab is interested in flagella/cilia, which works as an actuator aswell as a sensor of cells. We are studying the mechanism of formation andfunction of flagella/cilia using cryo-electron microscopy, optical
microscopy, and genetics. We are also developing new technologies toanalyze images taken by microscopes.
Our focuses are:• Molecular formation of flagella and axonemal dyneins.
• Mechanism of force generation by dyneins.
• Structures of microtubule-associated proteins• Development of new image analysis methods for cryo-electron microscopeThree dimensional reconstruction of the outer dynein armmicrotubule complex from wild type. A: rigor state and B:
relaxed state.

14

Cellular Neurobiology —————————————————————————————————————————The Laboratory of Cellular Neurobiology is interested in understanding the molecular mechanisms regulating synapse formationand maintenance, which are essential in proper function of neuralcircuits in the brain. The laboratory is using optical imaging ofsynaptic molecules in live neurons, in combination with molecular biological approaches to modify neuronal functions.

• Molecular architecture of the postsynaptic density• Molecular mechanisms of activity-dependent synapse remodeling• Regulation of synapse functions by glial cells• Regulation of synapse formation and maintenance in vivo

Quantitative fluorescence imaging of cultured hippocampal neurons (green: postsynaptic protein andcalibrated fluorescent microspheres, red: presynaptic
protein, blue: microtubule-associated protein)

Molecular Biology ————————————————————————————————————————————
http://www.cellcycle.m.u-tokyo.ac.jp

We have been studying the molecular mechanism enabling anchorage–independent S phase onsetthat is the key for malignant transformation.

• Understanding the anchorage signal cascades that
control cell cycling• Understanding the mechanism by which anchorage
signals control the G1-S transition

Cellular Signaling —————————————————————————————————————————————
http://biochem2.umin.jp/index_j.html

Our laboratory specializes in biochemistry, molecular and cellularbiology, and genetic engineering to elucidate the roles of lipid
mediators in vivo. We further study the molecular mechanism
and biological significance of diversity and asymmetry of cellular
membrane lipids. In collaboration with the Department ofMetabolome, we analyze stimulus induced dynamic changes in
the lipid composition of the cellular membrane.

• Discovery and structural determination of novel lipid mediators• Cloning, functional characterization and K/O studies of enzymes involved in
the metabolism of lipid mediators and receptors for lipid mediators• Structure, function and dynamics of GPCR
• Lipidomics and enzyme characterization of membrance organization
Production of lipid mediators during Lands’ Cycle and activation of
GPCRs(Shimizu,T., Ann. Rev. Pharmacol. Toxicol. 49, 123-150, 2009)15

1

Physiological Chemistry and Metabolism ———————————————————————————
http://bio.m.u-tokyo.ac.jp/

We are investigating signaling mechanisms underlying cell fate determination, morphogenesis andorganogenesis in embryonic development.

• Molecular mechanisms of neural crest fate determination and craniofacial
morphogenesis• Molecular mechanisms of cardiovascular development• Epigenetic control of embryonic development• Roles of microRNA in embryonic development

Transformation of the upper jaw into a lower jaw inendothelin-1 knock-in (misexpressing) mouse (upper).
The lower is the wild-type control.

16

17

1

Functional Biology

Integrative Physiology —————————————————————————————————————————
http://www.physiol.m.u-tokyo.ac.jp/indexe/indexe.html

Our laboratory specializes in the neuroscience research on cognitive functions in the primate. We
investigate interactions among many neurons in the cerebral
cortex, which create human cognitive abilities such as memory and its cognitive control. These studies have been done
through integrative efforts using electrophysiological,
molecular biological and neuroimaging approaches.

• Functions of memory neurons in the temporal cortex• Roles of the top-down signal from the prefrontal cortex• Functional differentiations of the prefrontal cortex in memory• Molecular biological basis of declarative memory in the primate• Development of high-field MRI for humans and monkeys

Brain activation in cognitive tasks (left) and gene
expression (BDNF) in cortical neurons

Cellular and Molecular Physiology ————————————————————————————————
http://morilab.m.u-tokyo.ac.jp/eindex.html

We aim at a better understanding of neuronal mechanisms involved in sensory perception of theexternal world and for the emotional state induced in the brain by sensory inputs. We are currently
analyzing the central nervous system for olfaction, a sensory modality that has a strong influenceon human emotion. Another major focus is to understand cellular and molecular mechanisms forcontact-mediated interactions between neurons and immune cells that occur in pathological andphysiological conditions.

• Functional analysis of the neuronal circuit in the central olfactory nervous system (Analysis of odor maps in the brain)• Neurogenesis and neuron-elimination in the adult brain• Cellular and molecular mechanisms for the contact-mediated interac-tions between neurons and immune cells in physiological and pathological conditions

Neuronal circuits and 'odor maps' in the olfactory nervous system

18

Neurophysiology —————————————————————————————————————————————
http://plaza.umin.ac.jp/~neurophy/

Our laboratory studies the function of the synapse, a key structure for brain functions, and itschanges related to postnatal development, learning, and memory. We make real time monitoring of
neuronal activities, using various methodologies
including electrophysiology, molecular biology, andoptical imaging of functional molecules.

• Postnatal development of synaptic function and organization in
the cerebellum• Retrograde synaptic modulation mediated by endogenous
cannabinoids• Synaptic integration in intact animals• Synaptic plasticity and motor learning in the cerebellum

Molecular mechanisms of endocannabinoid-mediated retrograde modulation of synaptic transmission

Cellular and Molecular Pharmacology ——————————————————————————————
http://calcium.cmp.m.u-tokyo.ac.jp/

Spatiotemporal distribution of signalling molecules is
extremely important in defining cell signals. We aredeveloping indicators of important signalling moleculesand visualize their spatiotemporal distribution within
intact cells. Using such novel imaging methods we aim
at elucidation of the physiological roles of calcium signalling and related signalling mechanisms in various
types of cells including neurons of the central nervous
system.

• Development of novel fluorescent indicators of signaling
molecules• Elucidation of the mechanism for spatiotemporal regulation of

Ca2+ signals• Exploration of new cellular functions that are regulated by Ca2+
signals• Visualization and analysis of molecular events at synapses

Outline of our research on Ca2+ signaling

Molecular Neurobiology————————————————————————————————————————
http://www.pharmacol2.m.u-tokyo.ac.jp/

We have been investigating the molecular basis of higher brain functions by focusing on the glutamate receptor and memory. Previous studies have led to the hypothesis that there is a common
principle between memory signaling and synapse formation. The combination of conditional gene targetingin mice and molecular genetics in zebra fish will facilitate our understanding of the mechanism of higher
brain function at the molecular, cellular and neural network levels.

• Regulation of brain functions by glutamate receptors in specificbrain regions• Identification of neural networks for learning and memory• Regulation of learning and memory• Roles of glutamate receptors in decision-making• Signaling from glutamate receptors to memory• Molecular mechanisms of synapse formation and remodeling• Molecular mechanism of synapse formation during development• Molecular mechanism of synapse remodeling in the adult brain

From synaptic molecules to brain function and dysfunction

19

3

Pathology, Immunology andMicrobiology

Pathology and Diagnostic Pathology ——————————————————————————————
http://pathol.umin.ac.jp/index_e.htm

We investigate the pathogenesis and pathobiology of disease, especially the neoplastic diseases, bymeans of morphology. Our goal is to discover new entities and to clarify unknown pathogenesis of
diseases through the interaction with clinical medicine.

• Chronic inflammation and neoplasm• Epstein-Barr virus associated gastric carcinoma• Epigenetics of carcinoma• Carcinoma-stromal interaction• Lung adenocarcinoma and its scar formation• Lung fibrosis and adenocarcinoma
Applicationof molecular pathology to pathological diagnosis•
Discoveryof cancer therapy target by DNA chip technology•• Establishment of objective criteria for cancer grading• Streamlining and acceleration of pathological diagnostic processes

Investigation of the development of EB virus-associated gastriccarcinoma

Molecular Pathology ——————————————————————————————————————————
http://beta-lab.umin.ac.jp/index.htm

Our research is focused on the molecular mechanisms of carcinogenesis. We study the signalingmechanisms of the TGF- β superfamily, including TGF-β and bone morphogenetic proteins (BMPs),
and elucidate how they regulate progression of cancers. We also investigate the mechanisms of differentiation of murine embryonic stem cells (ESCs) into various cells, including vascular and lymphatic endothelial cells. Based on these findings, we will develop new strategies for thetreatment of vascular and lymphatic diseases
and cancer.

• Molecular mechanisms of growth regulation by TGF-β• Roles of TGF-β in epithelial-to-mesenchymal transition• Negative regulation of TGF-β signaling by inhibitory
Smads and oncogene c-Ski
Differentiationof mouse ESCs into vascular cells
•
Roles
of
TGF-β
superfamily cytokines in vascular and•lymphatic diseases• Differentiation of vascular and lymphatic endothelial
cells and mechanisms of diseases

20

Signaling by TGF-β (left) and TGF-β-mediated EMT of mammry epithelial cells (right)

Microbiology ————————————————————————————————————————————————
http://microbiology.m.u-tokyo.ac.jp/

Our major objective is to elucidate molecular mechanisms underlying development of gastric carcinoma triggered by infection with Helicobacter pylori.
Based on the results obtained from these studies, weare also developing new strategies for prevention andtreatment of infection/inflammation-associated cancers,which account for 〜 50% of entire human malignancies.

• Structural biological analysis of H. pylori oncoprotein CagA
• Intracellular signaling pathways targeted by CagA
• Mouse genetic studies on gastric carcinogenesis• Host genetic factors determining gastric cancer susceptibility• Molecular mechanisms linking inflammation and cancer

H. pylori - gastric epithelial cell interaction

Infection Control and Prevention —————————————————————————————————We are engaged in education of medical staff as wellas in daily clinical activities on the preventionof healthcare-associated infection (HAI). Research activities on the pathogenesis of infection with
hepatitis viruses and HIV, in particular, on the mechanism of hepatocarcinogenesis in HCV infection
are also our mission.

• Development of preemptive strategies for the control of healthcareassociated infection• Development of new methods in infection control and treatment ofviral hepatitis• Molecular pathogenesis of hepatocellular carcinoma in HCV infection• Pathogenesis of progression of HIV infection• Molecular pathogenesis of the mitochondrial disturbances in viral
infections• Molecular pathogenesis of hepatitis B viral infection• Host defences to microorganisms• Molecular analysis of innate immunity in microorganism infection• New detection method and pathogenesis of opportunistic cytomegaloviral infection• Mechanism of multi-drug resistant microorganisms

Infection control teamroundsImmunology ————————————————————————————————————————————————
http://www.immunol.m.u-tokyo.ac.jp/english

Since its initial identification of the genes for interferon (IFN)-β and interleukin (IL)-2, our laboratory has continued to elucidate the signal transduction and transcriptional regulatory networks
involved in immunity and oncogenesis.

• The signaling and transcriptional networks that operate in the regulation of and by IFN-α/β during innate immune
responses,• The role and regulation of the interferon regulatory factor (IRF)

transcription factor family in innate and adaptive immune
responses,• The regulation of dendritic cell maturation/activation in the link
between innate and adaptive immunities,• The molecular mechanisms of protective and pathologicalimmune responses mediated by nucleic acid sensor proteins,• The regulation of oncogenesis by IRFs,• The regulation of mucosal immune responses.

Intracellular localization pattern of DAI (DLM-1/ZBP1) and its interaction
with B-DNA

21

4

Radiology and Biomedical Engineering

Radiology ——————————————————————————————————————————————————
http://www.ut-radiology.umin.jp/

We have been performing a variety of clinically oriented research programs in biomedical imaging,voxel-based or ROI-based analysis, information analysis and radiotherapy, such as computer-assisted diagnosis (CAD), PET-based diagnosis, and intensity modulated radiotherapy (IMRT).

• Diagnostic Radiology• Multi-row detector (up to 16 rows) helical computed tomography• MR imaging, MR digital subtraction angiography, perfusion imaging, anddiffusion tensor imaging/tractography
Radiation
Oncology•
Physicalengineering aspect of radiotherapy•• Stereotactic irradiation by gamma knife and synergy system and IMRT
• Clinical and biological studies for reduction of radiation-induced damage
Nuclear
Medicine•• Functional imaging by radioisotope-labeled tracer technology• Evaluation of blood flow and metabolism by emission tomography (PET and
SPECT)
Representative images analyzed with computerassisted technology

System Physiology ————————————————————————————————————————————
http://bme-sysphysiol.m.u-tokyo.ac.jp/

A variety of living cells respond to mechanical forces occurring both inside and outside a body. We
have been pursuing biomechanical research focusing on the effects of shear stress generated byflowing blood on vascular cells and circulatory functions. Our analyses range all the way from genes
to whole organs and systems. Research on the molecular mechanism of artherogenesis and biomechanical tissue engineering is
also ongoing.

• Vascular cell responses to shear stress• Identification of flow-sensing molecules• Mechanical stress responsive genes• Tissue engineering using mechanical stresses• Atherosclerosis research from the aspect of hemodynamics• Vascular system physiology• Microcirculation study using optical imaging

Mechanical force-loading apparatus and calcium response
in vascular cells

22Biosystem Construction and Control ———————————————————————————————
http://www.bme.gr.jp/bme_E/

Our research fields include medical engineering high-technologies represented by artificial organs.
Especially the research of artificial heart has gotten excellent results such as the world longest survival record in animal replaced with a total artificial heart. We are performing the researches fromthe basic to the application.

• Implantable total artificial heart• Implantable ventricular assist device• Polymer artificial valve• Next generation artificial lung
• Tissue engineered artificial organs• Blood compatible material• Implantable pressure sensor• Implantable angiogenesis observation probe• Space medicine1
Implantable total artificial heart (Undulation pump total artificial heart) and artificial heart animal (goat)23

5

Neuroscience

Neuropathology —————————————————————————————————————————————
Elucidate the pathomechanism of neuronal degeneration and deathin major neurodegenerative disorders (e.g., Alzheimer disease,
Parkinson disease), and develop novel strategies for disease-modifying therapies.

• Structural and functional analysis of γ-secretase• Molecular analysis of the mode of action of γ-secretase inhibitors• Mechanism of Aβ production, aggregation and clearance• Pathological function of β-amyloid binding proteins (e.g., CLAC)• Mechanism of aggregation and neurotoxicity of α-synuclein• Pathological function of familial Parkinson disease gene LRRK2• Strategies for development and validation of disease modifying therapies for
Alzheimer disease (J-ADNI Clinical Study)

Phosphorylated α-synuclein deposited in Lewy
bodies of Parkinson's disease and Lewy bodydiseaseNeurochemistry ——————————————————————————————————————————————
http://www.neurochem.m.u-tokyo.ac.jp/Homepage.html

Our brain is able to recognize and memorize external and internal events as they occur. A functional
neural network further stands out by its capacity to extract patterns and rules, and to associatethem with abstract meaning and affective valence. What are the local and global spectra of themolecular signaling events in neurons that underlie such complex
information processing at the systems level? Are these events, in turn,converted into more profound modifications of the synaptic wiring
mechanisms? To address these issues, we are currently investigating
the chemistry and physiology of various neuronal protein complexes
near and at synapses.

• Molecular investigation (including identification, characterization and real-timevisualization) of signaling molecules involved in calcium-dependent synaptic modification, especially during signaling from synapse-to-nucleus, and back from
nucleus-to-synapses• Understanding molecular mechanisms controlling cytoskeletal dynamics andremodeling on both sides of the synapses, in the dendritic spines and in axon terminals

24

Real-time measurement of biochemical events
triggered by glutamate uncaging at hippocampal spines (A); Visualization of actin cytoskeleton in cerebellar Purkinje cell dendrites (B)Neurobiology————————————————————————————————————————————————
http://www.neurobiol.m.u-tokyo.ac.jp/

The goal of our research is to elucidate regulation mechanisms of various cell functions. Toward
this goal, we have been developing novel technologies including live cell imaging and RNAi technologies.

• Development of novel strategy for generating fluorescent probes for live cell imaging
We develop a high-throughput screening system for constructing high performance fluorescent probes for live cell
imaging.
• Study of synapse physiology by glutamate imaging
techniqueTo clarify the dynamics of exocytosis in excitatory
synapses, we have tried to quantitatively analyze
released glutamate at individual synapses by using
our original optical glutamate probe.
• Novel technology for construction of genome-wide
RNAi library
We are currently constructing a high performance
genome-wide RNAi library based on our EPRIL technology.

Cognitive Neuroscience ————————————————————————————————————————
http://square.umin.ac.jp/dcntky/English/Etop.html

We are trying to understand the neural mechanisms of human cognition using functional MRI, EEG
and TMS.

• Working memory and cognitive control• Attention, perception and consciousness• Mind-reading and prediction of behavior

Neuropsychiatry —————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/n_md.html

Our department mainly investigates schizophrenia and pervasive developmental disorders not only
by biological approaches which integrate neuroimaging, genetic and animal studies, but also by psycho-social approaches. We also promote the systematic clinical research training programs and the cooperation with thebasic neuroscience research.

• Integrated Neuroimaging studies in Schizophrenia Targeting Early intervention and Prevention
http://plaza.umin.ac.jp/arms-ut/• Todai Twin Project with Integrative Neuroimaging
http://npsy.umin.jp/study/exam.html• Multimodal neuroimaging studies of pervasive developmental disorders• Clinical trials to establish the medical equipment as a clinical test usefulfor the pharmacological treatment of mental disorders

Multi-modality neuroimaging in neuropsychiatry using a combination of high-resolution MRI, EEG, MEG, NIRS, and PET

25

1

Neurology ——————————————————————————————————————————————————
http://square.umin.ac.jp/neurotky/

Our Department is promoting research programs to elucidate the pathophysiological mechanisms ofneurological diseases including neurodegenerative diseases, immune-mediated diseases and neuromuscular diseases, and to establish therapeutic approaches for these diseases. We are also providing excellent programs to train neurologists.

• Molecular Genetics (identification of disease genes and development of therapeutic approaches)• Molecular pathopysiology of neurological diseases (RNA editing,and protein structures)• Immune-mediated diseases (autoantibodies)• Neuropysiology and cognitive neuroscience (magnetic stimulation, NIRS, MEG, PET, and fMRI)• Neuropathology of neuromuscular diseases (pathological studies on biopsy and autopsy materials)• Multicenter-based clinical research• Development of new therapeutics

Neurosurgery————————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/neurosurg/

The 21st century has been designated as "The Century of the Brain". To lead Japanese Surgical
Neuroscience, we have devoted our activities to the following: advanced Clinical Neurosurgery,
Neuroscience Research and Graduate and Postgraduate education.

• Skull base surgery in managing benign or malignant skull basetumors and cerebrovascular disorders• Functional neurosurgery including epilepsy surgery• Development of new therapeutic strategies for malignat brain
tumors• Cinical study on gamma-knife surgery•Application of brain functional imaging for neurosurgery• Application of VR technology for surgical simulation• Experiment on cerebral ischemia• Development of new stenting device for endovascular surgery

26

Simulation images using 3D-fusion images and tractography.

27

Social Medicine

Molecular Preventive Medicine ——————————————————————————————————
http://www.prevent.m.u-tokyo.ac.jp/

Chemokines play critical roles in the pathogenesis of diseases including acute inflammtaion,
autoimmune diseases, allergic diseases, HIV infection, atherosclerosis and tumor metastasis
through the regulation of chemotaxis, activation and differentiation. We hope chemokine research
will contribute to Molecular Preventive
Medicine.

• Pathogenesis of diseases by chemokine• Autoimmune diseases, liver injury, GVHD
• Atopic dermatitis, bronchial asthma• Activation of the chemokine receptor and its signaltransduction• Serial analysis of gene expression (SAGE) for hematopoietic cells• Development of vaccinations to cancers and infectious
diseases

Public Health ————————————————————————————————————————————————
http://publichealth.m.u-tokyo.ac.jp/

Public health is the science and art of preventing disease, prolonging life, and promoting health andquality of life (QOL) through organized community effort. Through studies in various fields andlaboratories, our department aims to advanceresearch, support policy development, and promote education toward these ends.

• Efficiency and equity issues of health services• Health manpower policy• Occupational and environmental health• Policy analysis on health and environmental issues• Clinical epidemiology (QOL, outcome studies, economic
evaluation)

Physician distribution by municipality in Japan

28

Forensic Medicine ————————————————————————————————————————————
http://plaza.umin.ac.jp/~forensic/

We determine the cause of death in unnatural deaths through autopsy and various examinations.
We also study on legal-social systems related to death investigation, patient safety, and court. To
improve death investigation and related systems, we conducted variety of researches including cardiovascular basic sciences, legal-social medicine, toxicology,
DNA polymorphism, and forensic pathology.

• Involvement of Gap Junction in myocardial injury in ischemic heartdisease and arrhythmogenesis in restraint• Arrhythmogenesis and contractile dysfunction in pressure overload• Legal-social systems related to death investigation, patient safely, andcourt• Improvement of toxicological and DNA examinations• Forensic pathology

Forensic autopsy room

Medical Informatics and Economics ———————————————————————————————
http://www.m.u-tokyo.ac.jp/medinfo/index_e.html

The role of research and education of this department is provided as the department of the graduate school, and the role of practical management is conducted as the Department of Planning,
Information and Management in the University of Tokyo Hospital. All teaching staffs are in chargeof both the two roles and the department of health informatics
of school of public health. The research and postgraduate education programs cover basic medical informatics, advance applications of information technology for clinical practice, technology assessment and standardization of healthcare information.

• Development and application of clinical ontology• Research for sharing healthcare data among medical institutions and hospitals, and the application for clinical epidemiology• Extraction of medical knowledge from electronic medical record databaseusing natural language processing• Development of knowledge-driven real time alerting system in clinicalpractice• Evaluation study of hospital management and analysis of medical
resource placement

Computer room of the hospital computer center

29

6Internal Medicine

Cardiovascular Medicine ———————————————————————————————————————
http://plaza.umin.ac.jp/~utok-card/

We are investigating the pathogenesis, pathophysiology, diagnostic methods, and novel therapeuticmeasures of various cardiovascular diseases (ischemic heart disease, heart failure, cardiomyopathy,
arrhythmias, atherosclerosis, hypertension, etc.) using a variety of research tools (from molecularbiology to epidemiology, bioinformatics).

• Transcriptional regulation of various genes in cardiovascular development
and pathogenesis• Cardiac hypertrophy and heart failure: analyses of pathogenic mechanisms
and developments of novel therapies (gene therapy, etc.)• Immunological basis of cardiovascular diseases• Imaging techniques (echocardiography, MRI, CT, RI, NOGA) in cardiovascular diseases• Mechanisms of anti-arrhythmia therapy• Molecular mechanisms of ischemia-reperfusion injury• Genetic polymorphisms and risk factors in cardiovascular disease• Differentiation of smooth muscle cells (atherosclerosis and restenosis after
vascular interventions)• Mouse genetic models of cardiovascular diseases and vascular development• Neurohumoral factors in cardiovascular diseases
Respiratory Medicine ——————————————————————————————————————————
http://kokyuki.umin.jp/

Based on the fact that a number of patients with respiratory diseases including lung cancer and
COPD is tremendously increasing, fruitful results of respiratory research are more and more expected in the 21st century. In this era, we are conducting basic and clinical researches for wide variety of
respiratory disorders including lung cancer, asthma and COPD. Especially, we have been intensively
studying the molecular mechanisms underlying the pathogenesis of lung disorders. Our researchgoal is to develop novel therapeutic tools to manage these pulmonary diseases.

• Clinical studies of lung cancer, COPD, bronchial asthma and pulmonary fibrosis
studies of diffuse panbronchiolitis (DPB) and interstitial• Epidemiologicallung disease• Molecular mechanisms underlying the pathogenesis of acute lung injury or ARDS
• Molecular mechanisms underlying the pathogenesis of pulmonary fibrosis(as shown in Figure)• Analysis of disease models using genetically-engineered mice
• Effects of air pollutants such as diesel exhausts on airway hyperresponsiveness Roles of chemokines/cytokines and eicosanoids on airway epithelial
cells, smooth muscle cells and eosinophils.
• DNA methylation and lung cancer• Establishment of conditional vectors for hairpin siRNA knockdowns• Establishment of CpG island searcher

30

Murine model of pulmonary fibrosis

Gastroenterology ————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/gastro/

Our Department of Gastroenterology is one of the top institutions in the world in the treatment of
hepatocellular carcinoma by unique ablation(RFA) and gastrointestinal/pancreatobiliary cancer/stone byendoscopic manipulation(ESD&ERCP). The goal of our department is to accurately diagnose and givethe best available treatment to these patients, and to this end, we are performing a wide variety ofbasic as well as clinical research.

• Development of better therapeutic strategy for hepatitis B and C• Elucidation of hepatocaricinogenesis mechanism in viral hepatitis• Development of a better therapeutic modality for hepatocellular carcinoma& metastatic liver tumor• Elucidation of gastric injury mechanisms by Helicobacter pylori• Clarification of colon disease, especially right-sided colon carcinogenesis• Development of therapeutic strategy for advanced pancreatobiliary cancer• Development of a better endoscopic therapeutic modality forpancreatobiliary cancer/stone• Development of better diagnostic & therapeutic strategy for chronic pancreatitis• Development of an endoscopic en bloc resection method for early gastric,
esophageal and colonic cancer• Elucidation of the mechanisms of metabolism-associated liver diseases• Development of better diagnostic & therapeutic strategy for small intestinal diseases

Nephrology / Endocrinology —————————————————————————————————————
http://plaza.umin.ac.jp/~kid-endo/top.html

We are investigating the pathophysiology of renal and endocrine disorders for the development ofinnovative diagnostic and therapeutic tools. Hypertension is our special interest because not only it
is a serious medical problem which impairs many vital organs and the QOL of our patients, but also
we have the great advantage of organizing the strategic research aproach since hypertension isclosely related to both nephrology and endocrinology.

• Renal physiology and morphology• Pathophysiology of immune-mediated renal injury• Analysis of pathophysiology and prognistic factors of chronic renal failure• Endothelial injury and vascular biology in kidney disease• Role of nitric oxide and oxidative stress in renal disease and hypertension• Clinical and basic investigation of bone and mineral disorders• Mechanism of action of nuclear hormone receptors• Pathophysiology of hypertension and roles of adrenomedullin• G protein signaling in health and disease
Nutrition and Metabolism ——————————————————————————————————————We are investigating to reveal the molecular mechanisms underlying the development of metabolic
diseases (diabetes mellitus, lipid metabolic disorders, obesity, metabolic syndrome and atherosclerosis) using interdisciplinary approaches and state-of-the-art technology including genetically engineered model animals, DNA chip, epigenetics, RNA technology, human genetics, clinical epidemiology and bioinfomatics. Our major goal is to develop mechanism-based
fundamental treatment and prevention strategies for the metabolic
diseases.

• Molecular mechanism of insulin resistance linked to obesity focusing on adipokines• Transcriptional regulation of insulin resistance and obesity by nuclear receptors
and cofactors• Molecular mechanism of insulin signal transduction• Molecular mechanism of insulin secretory defect in type 2 diabetes• Genetic susceptibility and risk factors of type 2 diabetes• Development of accurate diagnostic algorithm for type 2 diabetes• Molecular mechanism of adipogenesis and obesity• Transcriptional regulation of lipid metabolism• Molecular mechanism of atherosclerosis• Mouse genetic models of diabetes, lipid metabolism disorder and atherosclerosis

31

Hematology and Oncology——————————————————————————————————————
http://www.h.u-tokyo.ac.jp/hematology/

We are investigating the pathogenesis, diagnostic methods, and novel therapeutics of hematologicaldisorders by making comprehensive use of research technologies in molecular biology, developmental biology, and immunology. Studies about transcriptional regulation and signal transduction inhematopoiesis and analyses of regulation ofhematopoietic stem cells are performed. We arealso performing basic and clinical studies basedon genomics, regenerative medicine, and transplantation medicine, which aim at application totherapeutic strategies.

• Self renewal and differentiation of hematopoietic stem
cells

• Genome-wide analyses of hematological malignancies• Identification of molecular pathogenesis of leukemia• Analyses of the immune system by developmental biology• Regenerative medicine of hematopoietic cells using
human ES and iPS cells

Allergy and Rheumatology——————————————————————————————————————
Allergy and rheumatic diseases are immune mediated disorders. We are investigating the fine mechanisms of such disorders. One of our final purposes is to establish novel therapies which control
pathological immune disorders but do not suppress other physiologically important immune functions. We are combining recent findings in basic immunology andour own viewpoints base on our clinical experience.

• Clonal analyses of T cell receptor (TCR) , in vitro reconstitution of the TCR

function using such information and antigen specific immunotherapy
Mechanismsof oral tolerance and application to therapeutic strategies•• Mechanism of immunological tolerance to autoantigens and immunoregulation• Development and induction of regulatory T cells and their applications• Intracellular signaling in immune disorders• Genomic analyses of rheumatic diseases• Development of molecular targeting immunosuppressive reagents• Airway hypersensitivity and remodeling of bronchial asthma• Mechanisms of IgE mediated allergic disorders and applications for therapies• Involvement of chemokines in allergic diseases and applications to therapeuticstrategies

Clonal analyses of T cell receptor (TCR) and in vitro
reconstitution of the TCR function for an antigen
specific immunotherapy

Infectious Diseases ————————————————————————————————————————————We are investigating both clinical and basic aspects in infectious diseaes, in particular, on HIV infection and hepatitis viral infections, the latter of which is the major cause of liver diseae worldwide.
Our research topics cover the wide areas in microbiology, immunology and pathobilology of infectious diseases, including HIV and HCV infections.

• Clinical studies of HIV infection• Development of new methods in infection control and treatment of viral hepatitis• Molecular pathogenesis of hepatocellular carcinoma in HCV infection• Pathogenesis of extrahepatic manifestations and its control in HCV infection• Pathogenesis of progression of HIV infection• Molecular pathogenesis of the mitochondrial disturbances in viral infections• Molecular pathogenesis of hepatitis B viral infection• Host defences to microorganisms• Molecular analysis of innate immunity in microorganism infection• New detection method and pathogenesis of opportunistic cytomegaluviral
infection• Mechanism of multi-drug resistant microorganisms

32

Stress Sciences and Psychosomatic Medicine ————————————————————————
http://psmut.umin.ac.jp/

The targets of our laboratory include stress-related diseases such as primary headaches and lifestylerelated diseases, eating disorders and malignancies. The goals of our work are to determine the mechanisms of these conditions, to develop objective markers for diagnosis and severity, and to discover new
treatment approaches using ecological momentary assessment (EMA), biochemical assessment of eating-related molecules, and physiological assessment of autonomic nervous function.

• We are using ecological momentary assessment (EMA) techniques to collect and evaluate subjective and objective data including physical activity
and autonomic nervous function in natural settings in stress-related diseases. We are also developing new treatments using these methods.
• Investigation into the pathophysiology, psychopathology and neurobehavioral basis of stress-related diseases by use of ecological momentary assessment methods• Using heart rate and blood pressure variability, we are investigating
autonomic nervous function in eating disorders. This work uses nonlinear analyses such as fractal analysis, as well as linear analysis.
• We have developed an egogram questionnaire, which we refer to as the
TEG.

Clinical Laboratory Medicine ————————————————————————————————————
http://lab-tky.umin.ac.jp/

The main goal of our research projects, described below, is the development of new and useful laboratory
tests, and elucidation of pathophysiology of diseases throughlaboratory tests.

• Elucidation of (patho)physiological roles of lysophospholipid mediators, and its application to laboratory medicine• Platelet biology, Hepatology• Genetic testing• Research on bioactive peptides, especially adrenomedullin• Oxidative stress and organ damage• Cell surface analysis and quantification of cell surface antigens using

flow cytometry• Analysis of the ventricle functions using ultrasound• Relationship between the respiratory function and various pathophysiological conditions• Magnetoencephalographic (MEG) study on neural mechanisms foraudiovisual integration
Flow cytometer and analysis patterns

Transfusion Medicine ——————————————————————————————————————————
http://square.umin.ac.jp/traf-tky/

Control, testing and supply of all blood products for transfusion are the main clinical activities of thedepartment of transfusion medicine, which is responsible for the provision of safe blood products andthe control of the transfusion practice in the hospital. It actively takes part in autologous blood collection, preservation, and supply for patients receiving routine surgery. In addition, apheresis proceduresfor collection of peripheral blood stem cells for transplantation, and of peripheral blood mononuclear
cells for dendritic cell-based vaccine therapy of cancer patients are performed. Also, lymphocyte-based
vaccine is prepared for the immunotherapy of recurrent abortion cases. Special laboratory testings,
including HLA typing (serologic and DNA-based) for bone marrow and organ transplantations and thedetection of anti-HLA, anti-platelet (HPA) and anti-granulocyte antibodies, as well as the phenotyping
and genotyping of platelet- and granulocyte-specific antigens for patients with adverse reactions after
transfusion, are performed. The research fields include 1) the development of immunological methods
for antigen-antibody testing of red cells, lymphocytes, granulocytes, platelets and endothelial cells, 2)
the development and clinical application of dendritic cell-based and other vaccines for immunotherapyof cancer, and 3) the development of new anti-thrombotic materials for clinical use.
• Detection of platelet alloantigens and alloantibodies /• Detection of leukocyte alloantigens and alloantibodies• Detection of anti-endothelial cell antibodies and investigation on their clinical relevance• Development of a novel method for the evaluation of platelet function• Dendritic cell-based immunotherapy for malignant diseases• Development of new anti-angiogenic strategies to treat cancer• Development of new immunotherapeutic approaches to treat malignant diseases• Development of new anti-thrombotic materials for clinical use /• Use of stem cells in regenerative medicine

33

8

Reproductive, Developmental andAging Sciences

Reproductive Endocrinology ————————————————————————————————————
http://square.umin.ac.jp/tkyobgyn/

We manage women's reproductive health comprehensively throughout their respective life stages(adolescence, reproductive ages, menopause, and post-menopause). We also aim to develop
advanced reproductive techniques, which could be practiced with higher success rates andimproved safety, based on experimental and clinical research.

• Establishment of effective and low-risk treatment for infertility• Development of assisted reproductive technology• Interaction between the endometrium and embryo during the implantation period• Pathophysiology of endometriosis• Local regulation of folliculogenesis• Technical development of advanced endoscopic surgery• Development of hormone replacement therapy for postmenopausal
women• Medical treatment for menopausal women

ICSI (intracytoplasmic sperm injection)

Gynecological Oncology ————————————————————————————————————————
http://square.umin.ac.jp/tkyobgyn/

We are developing the intensive surgical management andselection of the most suitable chemotherapy regimen, which
improved prognosis of the patients with ovarian cancer. The
basic researches are focusing on the mechanism of gynecological malignancies, especially cervical cancer. We have identified
the tumor suppressors involving in the process of cervical carcinogenesis. We are investigating a possible clinical applicationof the vaccine against human papillomavirus, which is acausative agent of cervical cancer.

• Intensive surgery including pelvic and paraaortic lymphadenectomy• Selection of adjuvant chemotherapy based on the pathological and molecular marker• Tumor suppressors involving carcinogenesis of gynecological malignancy• Analysis of the molecular marker in tumor cells related to clinical behavior• Prevention of cervical cancer using the human papillomavirus vaccines

Expression of tumor suppressor scribble in malignant cells

34Perinatal Medicine ————————————————————————————————————————————
http://www.iiosan.umin.jp/

The researches are on going for development of precise prenatal diagnosis on the fetal status using
ultrasonography. We are also focusing on the immunological aspects in patho-physiology of pregnancy, developing
the therapy for habitual abortion or pregnancy induced
hypertension.

• Early diagnosis of abnormal pregnancy• Development of three dimensional ultrasonography• Management of habitual abortion• Management of complicated pregnancy

Three dimensional ultrasonography of fetus

Molecular Cellular Reproductive Medicine ——————————————————————————We are approaching the molecular mechanisms in various reproductive pathological states, using
the knowledge and techniques of molecular biology, cellular biology and genetics. The studies areproceeding on the effects of endocrine disruptors on reproductive phenomena, such as embryogenesis, spermatogenesis and fetal development, and on the prenatal genetic diagnosis.

• Effect of endocrine disruptors on reproduction• Embryogenesis• Spermatogenesis• Intrauterine fetal development• Prenatal diagnosis using molecular genetics• Molecular mechanisms of embryonic development

Molecular mechanisms of endocrine disruptors

Pediatrics / Developmental Pediatrics ——————————————————————————————
http://square.umin.ac.jp/ped/

We are studying all the issues concerning the health of infants, children and adolescents. We haveachieved very important investigations to clarify the molecular pathogenesis of human congenital
disorders.

• Molecular diagnosis and analysis and collaborative treatment of intractable renal glomerular and tubular diseases• Molecular diagnosis and analysis of hematological malignancy and bone marrow transplantation• Study of Embryonic stem cell (ESC) treatments for various human congenital diseases• Diagnosis, molecular analysis and collaborative treatment of congenital heart diseases• Molecular analysis and collaborative treatment of congenital immunodeficiency and allergic diseases• Collaborative treatment of extremely premature neonates and babies withpulmonary hypoplasia• Enhancement of the immunological resistance of premature neonates
using a new type of lactobacillus• Diagnosis and treatment of neurological, endocrine and metabolic diseases• Collaborative study and treatment of psychological disorders• Investigation of new systems to promote mother and baby co-relationships during rearing

35

Pediatric Surgery —————————————————————————————————————————————
Pediatric surgical diseases have great variety. In our department all kinds of pediatric surgical conditions are treated, and in these fetal and neonatal surgical care is our main interest. We also treat
many pediatric patients using minimally invasive surgeries such as laparoscopy and thoracoscopy.

• The development and differentiation of the fetal lung
• Fetal diagnosis of congenital malformations• Fetal surgery and treatment• Pediatric minimally invasive surgery• Probiotics and prebiotics applied to padiatric surgical patients• The development and differentiation of intestinal lymphoid organs• Renal functions in congenital hydronephrosis• Biliary atresia and biliary dilatation: their treatment and long-term
prognosis• The treatment by regenerative medicine of air way malacia andstenosis

EXIT(ex utero intrapartum treatment):Tracheostomy on a fetus
with laryngeal atresia

Pediatric Oncology ————————————————————————————————————————————
Solid tumors in children are dealt with in our department. Appropriate care strategies combining
surgical treatment and chemotherapy are decided and carried out on various malignant tumors after
extremely close discussion with pediatric oncologists.

• Genetic analysis and investigations for prognostic factors in neuroblastoma• Tumorigenesis in Wilms tumors• Analysis of cellular biology in Wilms tumors• Treatment of rhabdomyosarcoma• Genetic mutation in hepatoblastoma

Microscopic and ultramicroscopic features of Wilms tumor
cell line

Geriatrics ———————————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/1510rounenbyou.html

Our department is the first established department of Geriatric Medicine in Japan. It is our goal totreat all the geriatric diseases, such as atherosclerosis, hyperlipidemia, osteoporosis, senile dementia, diabetes, COPD, and aspiration pneumonia, and to improve the quality of life of elderly patients.

• Vascular endothelial function and atherosclerosis• Studies of molecular mechanisms in vascular calcification• Antioxidants inhibit vascular smooth muscle cell proliferation andinduce apoptosis• Vascular gene therapy using adenoviral mediated gene transfer of
estrogen receptors• New guidelines for hormone replacement therapy in females in Japan• Novel gene responsible for breast cancer• Novel gene responsible for osteoporosis• Molecular cloning of novel Ring finger protein• Studies of pathophysiology and novel treatment for Alzheimer's disease• Pathophysiological studies on bronchial asthma using gene-targeted
mice• The antimicrobial peptide, defensin• The molecular mechanisms of vascular injury in sleep apnea syndrome

36

37

9

Surgical Sciences

Cardiovascular Surgery, Thoracic Surgery ———————————————————————————
http://ctstokyo.umin.ne.jp/

We are leading in Japan by annual surgery case volume of 700. New knowledge and techniques areactively applied clinically. Many clinical research projects are going on along with routine clinicalactivities. Our laboratories have been also carrying out a large variety of basic research.

• Clinical research• Brain and spinal cord protection in thoracic aortic surgery• Minimally invasive cardiac and thoracic surgeries• Valve or vascular tissue allograft transplantation• Ventricular assist device for end-stage heart failure• Pathophysiology of thymic epithelial neoplasms• Basic and experimental research• Development of myocardial regeneration therapy• Analysis of resistance to infection of tissue allograft• Analysis of suppressor gene of lung cancer

MRI diffusion-weighed images of brain by various brain perfusion
techniques

Gastrointestinal Surgery ———————————————————————————————————————
http://todai3ge.umin.jp/

Our research activities range from basic topics to clinical ones with close interconnections. Basic research topics encompass underlying molecular mechanisms
and the regulation of carcinogenesis, progression, metastasis and prevention ofgastrointestinal cancer. Clinical research topics include the establishment of tailored treatment strategies from a patients-by-patient point of view, which ultimately provide a better quality of life while improving survival quality.

• Carcinogenesis, progression, metastasis and prevention of gastrointestinal cancer• Inflammation and gastrointestinal carcinogenesis (gastroduodenal reflux, H. pylori infection)• Are cancer cells derived from bone marrow?
• Earlier detection of cancer and micrometastasis by new genetic markers• Roles of epigenetic alteration (DNA methylation) in gastrointestinal carcinogenesis• Carcinogenic analysis with murine esophageal reflux model• Establishment of tailored treatment strategies• Less invasive treatment of early cancer by laparoscopic (assisted) surgery• Sentinel node navigation surgery for early cancer• Extended radical treatment of advanced cancer• Induction of neaoadjuvant chemotherapy and improvement of survival• Estimation of chemotherapy effects by new bio- and genetic-markers• Alternative gastrointestinal reconstruction and estimation of the results

38

Barett's esophagus and Cancer in
reflux model mouseHepatobiliary Pancreatic Surgery —————————————————————————————————
http://square.umin.ac.jp/hbp-t/index21.htm

We constantly perfom nearly 200 hepatectomies every year on
patients with hepatobiliary malignancies including hepatocellular carcinoma and metastatic liver tumors. The surgical results can be classified as amongst the highest ranking in the world. In order to improve
the surgical outcome for hepato-biliary-pancreatic malignancies, we
conduct wide areas of research such as analysis of prognostic factors
for liver malignancies, evaluation of liver hemodynamics using ultrasonography, liver ischemia/reperfusion injury, and liver regeneration.
• The development of a radical and safe operative procedure for hepato-biliary
malignancies• The analysis of genetic abnormalities in hepatocellular carcinoma• Development of new methods for the evaluation of liver functional reserve• The evaluation of hemodynamics in the congested liver using ultrasonography• Study of the effect of ischemic preconditioning on liver normothermic
ischemia/reperfusion

Color flow mapping of intra- Color flow mapping of intraoperative Doppler ultrasonography
operative Doppler ultrasonography before division after transection of the middleof the middle hepatic vein. hepatic vein. Portal flow was hepPortal flow was hepatopetal atofugal (shown in blue) in theveno-occlusive area.
(shown in red).
Preoperative 3-D imageof the liver constructedby simulation software.
Accurate anatomy ofvasculatature and tumor
location is analyzed.

Urology ————————————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/urology/

We constantly perform more than 1,400 urological surgeries a year,
including nephrectomy, cystectomy and prostatectomy, with increasing
trend of laparoscopic maneuvers and brachytherapy for organ confined
prostate cancer. Surgical or Non-surgical means are employed for noncancer diseases including renal transplantation, urinary dysfunction,
urinary incontinence, urolithiasis and male infertility. With regard tolaboratory research, not only oncology but also JC virus, PCK diseaseand vascular biology are now under extensive investigation.
medicines on estramustine phosphate (EMP) has been investigated for• Tailor
newly diagnosed advanced prostate cancer (Fig.1)• JC viral genomic analyses and its distribution in the world• Estrogen receptor beta and its metabolic cascade analysis• Hormonal regulation of prostatic proliferation and atrophy
E&H-cadherin correlation with invasiveness of transitional cell carci• Humannoma and prostate cancer• Oncolytic viral therapy using HSV-1 (Fig.2)• PCK disease and genetic analysis• Urolithiasis: ion channels membrane transport (NaDC-1)• Vascular biology and erectile dysfunction (ED)• Fluorescence in situ hybridization (FISH) flow cytometry• Immunotherapy for renal cancer by IL-2 blocking with anti-IL-2-mAb

Fig.1 Overall Survival; EMP 2Cp versus EMP 1Cp + LHRH agonist

Fig. 2 The combination therapy of oncolytic HSV-1 withandrogen ablation led to significantly enhanced inhibition of the tumor growth.

Artificial Organ and Transplantation Division ————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/1512ishokugeka.html

We are doing the clinical studies about liver transplantation for end staged liver diseases. We have performed 434
living donor liver transplantation and 9 deceased donorliver transplantation until June, 2009.

• Surgical technique of liver transplantation• Diagnosis and treatment of acute rejection• Diagnosis and treatment of postoperative infection

The 5-year survival rate for adult cases was 85%, which is significantly superior to that of the national data (70%)

39Surgical Oncology / Vascular Surgery ——————————————————————————————
http://all-1su.umin.jp/

We had a great deal of experience in treating patients with various cancers and vascular diseases,
and we have performed much research on carcinogenesis, cancer metastasis, immunology,
atherosclerosis, angiogenesis and vascular regeneration. Based on
the research results, we are trying to identify the best way to treat
each patient with the least surgical stress.

• Development of the novel and order-made therapy for cancer• Genetic mutation analysis of various cancers• Radiosensitivity and chemosensitivity of cancer• Intraperitoneal chemotherapy for peritoneal carcinomatosis• Immunotherapy using dendritic cells• Characterization of tumor vasculature and its therapeutic application• Gene therapy for disseminated metastasis• Drug development to target the receptor and signal transduction cascade of bioactive
lipids• Development of a novel method to diagnose and treat the vascular diseases• Vascular regeneration therapy for atherosclerotic obliterans (ASO)• Visualization of atherosclerotic lesions• Robotics surgery for vascular diseases

Diagramatic representation of clinical-oriented
research, with the ultimate goal of improving
patient QOL

Metabolic Care and Endocrine Surgery —————————————————————————————
http://todai3ge.umin.jp/

Our department has two main divisions. Division of surgical metabolism and nutrition performs
research on vital response to surgical stress and on metabolic and nutritional care during peri-surgical period. Division of breast and endocrine surgery performs surgery for 230 cases of breast, thyroid and parathyroid tumors a year, and performs research on
tumorigenesis, establishment of treatment and prevention of breast
and thyroid cancers.

• Surgical metabolism and nutrition• Induction of tolerance against surgical stress and endotoxemia• Response to endotoxemia through Toll-like receptors• Effects of surgical stress on tumor development• Gender difference in the response to surgical stress• Bacterial translocation during chemotherapy for cancer• Establishment of metabolic care and nutritional support team• Breast and endocrine surgery• Roles of nuclear receptor in development of breast cancer• Micrometastasis of breast cancer• Diagnosis of breast and thyroid tumors by fluorescence in situ hybridization of telomere• Expression of insulin-like growth factor 1 receptor in breast cancer tissue as prognostic factor
Detection of telomere and centromere by Fish. Fluorescence• Roles of carbohydrate in breast cancer metastasis
volume of telomere attenuates with increase of cell division.
Establishmentofevaluation
on
QOL
of
the
patients
withbreastcancer(red: telomere, green: centromere, blue: chromosome)•

Dermatology ————————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/der/Our department actively performs the following cutting-edge, multifaceted research projects thatwill be put into clinical practice in the future.

• Molecular mechanisms of immunological abnormalities and skin and lung fibrosis in scleroderma• Development of novel therapies to scleroderma, including B cell depletion therapy• Relative contribution of various cell adhesion molecules and chemokines toinflammatory conditions• Identification of novel autoantibodies and their clinical significance in connective tissue diseases
roles of B lymphocytes, especially regulatory roles, in inflammatory disor• New
ders• Immunological abnormalities of atopic dermatitis
Skin fibrosis induced by bleomycin(left) is inhibited in CD19-deficient mice(right)

40

Plastic and Reconstructive Surgery ————————————————————————————————
In our lab, we are investigating the mechanisms of morphogenesis of congenital anomalies using adevelopmental biological approach. In addition, we are performing extensive research into the clinical application of engineered tissues such as skin, soft tissue, and cartilage. We also have several
cosmesis-related projects such as clinical hair regrowth with cultured cells and analysis of skinaging mechanisms.

• Basic Research• Mechanisms of embryonic craniofacial morphogenesis • Angiogenesis inembryo and vascular malformations • Mesenchymal stem cells derived
from lipoaspirates • Organ engineering with human adult stem cells• Hair regrowth with cultured dermal papilla cells • Research on aging skin-related
factors • Regulation of skin aging using hormones and retinoids • Regulation of
epidermis by factors derived from dermal fibroblasts• Clinical Research• Ultramicrosurgical reconstruction using vascularized tissue transfers• Reconstructions for established nerve palsy • Esthetic microneurovascular surgery • Mechanism and surgical treatments of lymphedema• Vascularized ovarial preservation and transplantation • Free vascularizedtransfers of nerve cells, muscle cells, adiposal cells, and lymphnodes

Supermicrosurgical vascularized nerve graft. 100% of
Schwan cells within a nerve graft can survive withmicrovascular anastomosis(0.5mm).

Oral and Maxillofacial Surgery ———————————————————————————————————
http://plaza.umin.ac.jp/~oralsurg/

Our laboratory has been performing a wide range of clinically oriented research in oral-maxillofacial
disorders such as congenital diseases, jaw deformities and tumors in the oral region. Cartilage andbone regeneration using tissue engineering techniques is our main field of research.

• Clinical research:• Correction of facial deformity in patients with cleft lip and palate• Facial growth in craniofacial anomalies• Surgical-orthodontic treatment of dentofacial deformities• Evaluation of the treatment outcomes in patients with cleft lip and/or palate• Clinical application of artificial bone that displace into bone
• Implant type artificial bone generated from tissue engineered human chondrocyte• Basic and experimental research:• Cartilage and bone regeneration using the tissue engineering technique• Gene analysis of congenital anomalies in the oral and maxillofacial region• Effect of free radicals on bone metabolism• COX-2 regulation on bone metabolism• Development of intelligent type of artificial bone invested with osteogenic differentiation factors• Development of tetra pod type micro artificial bone unit

Cartilage and bone regeneration using the tissue
engineering technique

Orthopaedic Surgery ——————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/ortho/

Our department was established in 1906 as the first department of orthopaedic surgery in Japan.
Since then our efforts have been dedicated to responding to the needs of patients for orthopaediccare and to related research. Our department seeks to elucidate the molecular and genetic backgrounds of bone and cartilage disorders in order to develop groundbreaking treatments for these
conditions. At the same time, we are attempting to establish various clinical devices.

• Systemic and comprehensive study for osteoarthritis• Bone, cartilage and nerve regeneration• Regulation of anabolic and catabolic bone metabolism by cytokines• Molecular mechanism of age-related bone loss
• Molecular mechanism of osteoclast differentiation and apoptosis (RANKLRANK, INF, Src)

• Gene therapy to control pathological bone destruction (arthritic bone resorption and arthritic joint destruction) using adenovirus vectors• Non-invasive analyzing system to evaluate the mechanical properties ofskeletal system in vivo using CT based finite element analyses• Surgical navigation system with a three-dimensional display and navigation
robot

Surgical navigation system

41

Ophthalmology ——————————————————————————————————————————————
http://plaza.umin.ac.jp/oph/

Our department applies cutting-edge technologies and knowledge to diagnosis and treatment ofeye diseases. To elucidate pathogenesis and establish more efficient ways of diagnosis and treatment of various refractory eye diseases, basic researches utilizing molecular biological, immunological and/or pharmacological techniques and clinical studies utilizing epidemiological, biostatistical
and/or optical methods are conducted. Our efforts are also dedicated to regenerative medicine of
the cornea and retina.

• Investigation of primary glaucomas and relating factors• Development of new methods of glaucoma treatment and validation by RCTof new ocular hypotensive drugs and their mechanism of action• Investigationby using transgenic or KO mice or experimental glaucoma monkeys
of mechanism of neural cell death by using cultured RGCs or retinal• Investigation
glial cells and exploratory search for new neuroprotective agents• Analysis of ocular circulation in glaucoma and retinal diseases• Analysis of corneal topography and wave-front analysis of optical aberrationsof tissue-engineered cornea by using cultured stem cells of• Development
corneal endothelium and epitheliumof molecular mechanism of choroid-retinal neovascularization• Investigationand new drug delivery system for it utilizing nanotechnology• Regenerative medicine of the retina using retinal stem cellsof immune responses in rejection of transplanted cornea and• Investigationrole of chemokines and receptors in uveitis
Otorhinolaryngology and Head & Neck Surgery ——————————————————————
http://www.h.u-tokyo.ac.jp/orl/

Our research is composed of both clinical and basic research. Clinical research is conducted by specialized clinics in the hospital, which experience ear diseases and hearing disorders from neonates
to adulthood, head and neck cancer, paranasal diseases, olfactory and disorders, vertigo and balance disorders and voice and swallowing disorders. Basic and experimental research into molecularbiology, electrophysiology and morphology is conducted in our department's laboratories.

• Clinical research• Cochlear implantation in deaf children and their development of hearing, speech and language• Surgical correction of congenial microtia and atresia and postoperative radical ears to improve
hearing• Quality of life in patients with head and neck cancer to restore speech and swallowing function• Vestibular research on the oculomotor and balance system and myogenic potential• Navigation of the paranasal sinuses and skull base surgery• Surgical treatment of voice and swallowing disorders• Basic and experimental research• Molecular biology of the inner ear• Molecular biology of epipharyngeal cancer and hypopharyngeal cancer• Molecular biology of differentiation and development of inner ear and olfactory epithelium• Origins of vestibular myogenic potential• Aging and regeneration of olfactory epithelium• Binaural hearing
Chochlear implant

Rehabilitation Medicine ————————————————————————————————————————
Our research purpose is to improve the provision of a unique and comprehensive rehabilitation service enabling people to develop their full potential and often returning from being a “patient” tobeing a “person”. Clinically oriented studies concentrate on elucidation of the origin of disabilities
to cause activity limitation and restriction of participation.

• Gait analysis• 3-dimensional image analysis with a infrared camera system• Measurements of 3 dimensional ground reaction forces with aforce platform• Measurements of foot pressures with a computerised pressure
sensor• Clinical research on intractable rare diseases• Fibrodysplasia Ossificans Progressiva• Congenital Insensitivity to Plan

• Clinical research on congenital limb malformations• Research on the effect of rehabilitation in palliative care
Gait analysis

42Anesthesiology ——————————————————————————————————————————————
http://www.anes.umin.ne.jp/

We conduct research into various subjects concerned with anesthesia and the pain clinic. There are 6
laboratories in our department. Comprising respiratory, circulatory, nervous and muscular, immune andpain research, and research into anesthetic instruments including monitoring systems.

• Respiratory system Our areas of research include changes in pulmonary vascular resistances in pulmonary edema; and influence ofanesthetic drugs on the pulmonary system; and pathophysiological changes in neurogenic pulmonary edema• Circulatory system Studies are now being perfomed on the relationship between the sympathetic nerve system and cardiac function; the influence of inhibitory enzymes upon organic microcirculations; and the ventilation-perfusion distributions during artificial positive pressure ventilation• Nervous and muscular system Studies are now in progress on the mechanism of epidural-spinal anesthesia(using Hanaoka's needle); theinfluence of anesthetics on the auditory brain stem response; the influence of inhalation anesthetic drugs on the autonomic nervous system; and thepharmacology of neuromuscular blocking agents; and the development of a new monitoring
system for neuromuscular blockade• Immune system Themes include the response of immune systems to endotoxins inblood and the influences of anesthetics on hepatic Kupffer cells• Pain We have perfomed many studies in this area, including the effects of epidural
drugs on thermal nociception with different stimulus intensity; the clinical applications ofcurrent perceptive thresholds; the mechanism of the analgesic action of laser energy; theclinical applications of drug challenge tests; the examination of the application of epidroscopic therapy; the analgesic mechanism of hyperventilation; the applications of patient
controlled analgesia; the effects of epidural narcotics; and the optimal combination of low
dose opioids and inhalated anesthetics• Anesthesia machines and other medical equipment The development ofsimulators for anesthetic education, and the development of new equipment for tracheal intubation are now in progress
Anesthesia and monitors

Emergency and Critical Care Medicine —————————————————————————————We are collaborating with the School of Engineering, and now concentrating on the development of
the infrastructure of emergency medicine including “the Vital Care Network System”, which allows
us to manage continuously large numbers of high risk patients. We are also making efforts toimprove sterilization and wound healing.

• Vital Care Network System• Telemonitoring system for prehospital medicine• High-performance transfer system for the ambulances• Electrolyzed water• Autonomic nervous system regulation of the heart

43

Health Sciences and Nursing

Health Sociology —————————————————————————————————————————————
http://www.hlthsoc.m.u-tokyo.ac.jp/index.htm

Our department studies social and psychological factors related to health problems and health caresystems, through developing and applying theories, concepts and methods, which have been developed in sociology and social psychology. We carry out studies in interdisciplinary academic fields,
involving health, medicine and nursing as well as the field of sociology.

• Studies on Antonovsky's Salutogenesis and Sense of Coherence (SOC)• Study on medically infected HIV subjects• Studies on the current situation and theories of changing professionalpatient relationship and patient autonomy• Studies on the effects of changes in industrial society on “Ways ofWorking and Living” and fatigue / stress among wokers• Studies on social differences and inequalities in health• Development of health sociological researches and theories for people
living with illness/stress
An example of a visual presentation on research results

Mental Health / Psychiatric Nursing ———————————————————————————————
Our departments conduct research on mental health and psychosocial stress and provide education/
training of professionals in related fields from global perspectives.

• Mental Health• Mental health epidemiology• Occupational mental health/Occupational health psychology• Psychoeducation/Stress management• Evaluation of school counseling• Practice and Evaluation of Psychotherapy• Early detection and therapeutic education of PDD• Psychiatric Nursing• Supporting people living with mental health problems• Practice and evaluation of home visiting psychiatric nursing• Illness self-management in mental health• Recovery for people with mental illness• Patients' satisfaction with psychiatric services

44

Biostatistics / Epidemiology and Preventive Health Sciences —————————————
http://www.epistat.m.u-tokyo.ac.jp/

Biostatistics and epidemiology provide the methodological basis for health sciences. We are conducting basic methodological research of biostatistics and theoretical epidemiology as well as consultation
works and collaborative projects with basic/clinical researchers. The NPO “Japan Clinical Research
Support Unit” established by the staff of the department is supporting investigator-initiated clinical
trials and large-scale epidemiological studies in respect of data
management, statistics and quality assurance.

• Methodological research• Design of clinical trials• Analysis of correlated data and longitudinal data such as QOL data,
multiple recurrence (events) data
• Causal inference• Collaborative projects• Japan Arteriosclerosis Longitudinal Study• Comprehensive Support Project for Oncology Research- Breast Cancer• Comprehensive Support Project for Adequate Treatment of Osteoporosis• Investigator-initiated clinical trials of cell therapies

Social Gerontology ———————————————————————————————————————————
http://www.sg.m.u-tokyo.ac.jp/informatione.htm

The three major research areas of this department include social gerontology, psychosocial oncology and biomedical ethics. The faculty and graduate students are multidisciplinary and include those
whose primary training is in nursing, medicine, psychology, anthropology and health sciences.
Using the theories and research methods of those disciplines, we aim to suggest practical ways todeal with a wide variety of public health problems.

• Exchange of social support and subjective well-being among the elderly• Psychological well-being among the elderly who have experienced
relocation• Measurement of active life expectancy• Sexuality and body image issues related to cancer treatments• Treatment decision-making process among cancer survivors• Self-help group activities for chronic, life-threatening illnesses• Psychosocial issues related to infertility treatments• Multi-disciplinary collaboration in the clinical setting

Class meeting of the department

Health Promotion Sciences ——————————————————————————————————————
http://www.ethps.m.u-tokyo.ac.jp/

The main research activities of the Department of Health Promotion Sciences are experimental and survey research concerning health behavior and life-style related diseases. Our research results contributeto the proposals of health care systems, and health policy concerning health promotion in the community and the workplace.
Our classes include lectures and practical training and students
are required to understand the methods of planning, implementation and evaluation of the health promotion programs in thecommunity and the workplace.
Specific research topics include:• Development of effective health promotion programs• Assessment of the supportive environments in the community and theworkplace• Evaluation of the supporting methods for health behaviors• Short- and long-term effects of behavior change• Influence of behavior change on medical costs, and cost effectiveness analysis• Social and physical environmental determinants of the adherence of
behavior change

A scene as part of a community health promotion program45

Biomedical Ethics —————————————————————————————————————————————
http://www.ethps.m.u-tokyo.ac.jp/

The Department of Biomedical Ethics conducts both theoretical and empirical studies in the fieldsof biomedical ethics, research ethics and clinical ethics. Research topics include ethical theories,
informed consent, ethics committees and organ transplantation. The Center for Biomedical Ethics
and Law (CBEL) was recently set up as an adjunct to the Department of Biomedical Ethics.
(http://www.cbel.jp/)• Study of the functions and responsibilities of ethics committees

in Japan• Study of the methods for the formation of social consensus related to advanced medical technology• Comparative study of clinical ethics in the Asian region• Publication of a medical ethics case book for Japan• Acceptability of advance directives in Japan• Development of evaluation methods for biomedical ethics education• Psychosocial and ethical aspects of living related organ transplantation

Outreach Program: CBEL provides training courses for ethics committee members. Participants include physicians, nurses and medical pharmaceutical representatives.

Nursing Administration / Advanced Clinical Nursing ———————————————————
http://nurs-adm.umin.jp/

Our research programs aim to support clinical nurses in providing high quality care for theirpatients in efficient way. Under a nation-wide healthcare reform, improving the efficiency ofhealthcare delivery systems becomes essential. For nursing care, assessing the efficacy and theputting in place of quality assurance systems are
required. Applying management theories to nursing
administration, we focus on nursing quality improvement, nurse staffing, patient classification systems, budgetary management, staff development and continuing
education.

• Evaluation and improvement of quality of nursing care
• Benchmarking of nursing quality indicators• Outcome management for nursing practice• Risk management• Human resources management• Nursing case management and critical pathways• Effect of care environment on patients• International comparison of nursing quality indicators• Nursing policy and economics

Promoting quality nursing care

Family Nursing ———————————————————————————————————————————————
http://www.hn.m.u-tokyo.ac.jp/dept/famn/indexj.htm

Hand-in-hand with the changes occurring in society, the formation and the function of the family isalso changing. Current Japanese society expects not only client-centered perspective but also family-centered perspective from nursing research. We are especially focusing on the childrearing andchildbearing family nursing research issues.

• Late effects of treatment and posttraumatic stress disorder in children with cancer• Psychological preparation for children undergoing minor surgery• Prevention of child abuse and neglect• Care of dying children and their families• Childbearing family formation process• Postnatal depression and difficulties in childrearing46

Community Health Nursing —————————————————————————————————————
http://park.itc.u-tokyo.ac.jp/chn/english/index.html

Our research focuses on the development of health care programs, and establishment and evaluation of community health care systems, in response to the health care needs of individuals, families, aggregates and the communities. Also, we are performing research on standardization of skills of publichealth nurses.

• Establishment and evaluation of community health care systems• Around-the-clock in-home care system• Expansion of the target of visiting nurse• Hospital discharge planning• Comprehensive community care, care-networking• Development of health care programs• Support for people with diseases or disabilities• Support for families with babies and children• Elderly care
• Occupational health• Definition and standardization of skills of public health nurses/
Development of community health program

Concepts of the Community Health Nursing

Adult Nursing / Palliative Care Nursing —————————————————————————————
http://www.adng.m.u-tokyo.ac.jp/indexe.htm

Mainly for subjects in their adulthood, we have been performing research in a variety of domains
including prevention of diabetes and several chronic illnesses, support for coexistence with disease, and palliative care. Focal points in our research, which we conduct under a team approach, arestrategies in education and provision of relevant information based on the findings of molecularbiology, and the team-approach nursing care system.

• Prevention and self care support for chronic illness• Development of HR-QoL scale for patients with chronic illness• Physical activity in middle- aged / elderly• Nursing care system for transplantation recipient / donor• Genetic counseling in nursing• Evaluation of palliative care services• Continuity and dissemination of palliative care
• Nursing care system for out patients

Midwifery and Women's Health ——————————————————————————————————
http://park.itc.u-tokyo.ac.jp/midwifery/index1eng.htm

Having been in place since June, 2002, our research activities focus onmaternal-child health care as well as health promotion to achieve an allround good life for the well woman.

• Life style and oxidative stress during pregnancy• Maternal body composition during pregnancy and infant birth weight• Nutrition and weight management during pregnancy and postpartum• Assessments of quality of life among pregnant and postpartum women• Promotion of women's health care after delivery• Change of posture and the local muscle system during pregnancy and postpartum• Stress urinary incontinence and inner-unit in postpartum and middle-aged women• Evaluating the predictive ability of biomarkers related to uterine contraction for the
progress of labor

Photo by Sakae Kikuchi

47

Gerontological Nursing / Wound Care Management ———————————————————
http://www.rounenkango.m.u-tokyo.ac.jp/english/index-e.html

The goal of our department is to achieve “Evidence-based practice and development of gerontological nursing and wound care management”, where we are striving to develop new techniques, instruments, and assessment skills in accordance of nursing science and engineering and clinical nursing.
Especially, translational research is our focus in which the basic science will be translated into clinical science. We are featuring the development of evidence-based skin care for improving skin function in theelderly.

• Development and evaluation of wound management technology
and devices• Elucidation of pathophysiology and its diagnosis technology ofwound• Development of technology and devices for wound management andprevention• Evaluation of new technology and devices• Development and evaluation of evidence-based skin care methodology• Investigation of bioengineering aspect of elderly skin
• Exploring of objective parameter of skin status• Development of intervention methodology for improving skin function48

Example of translation research in our department

49

International Health

Global Health Policy ———————————————————————————————————————————
http://www.ghp.m.u-tokyo.ac.jp

Our mission is to improve population health by enhancing accountability and improving evidencebase of global (both domestic and international) health programmes through the provision of best
possible information and rigorous monitoring and evaluation. The department's members generateknowledge and ideas through their research, strengthen technical and leadership skills through educational programs, and enhance national capacities through collaborative projects, especially in thedeveloping world.
The priority areas of research are:
1. Health outcome research (mortality, morbidity and disability, health services,
cost-effectiveness of interventions, disease modeling, resource flows, andimpact evaluation, including tracking the progress towards the Millennium
Development Goals and contribution to the Global Burden of Disease study);
2. Health system performance assessment, including the analysis of health system inputs (evidence on financing and human resources), outputs (service
delivery, effective coverage), and impact (health status); and3. Health and foreign policy (e.g. global health architecture and governance, G8
and global health, donor commitments).
Finally, the fundamental role of the Department is to produce the next generations of leaders in global health.

Community and Global Health ———————————————————————————————————
http://www.ich.m.u-tokyo.ac.jp/

Our Department aims at bringing together clinical, public health and social science research to address
following aspects of international health. We also conduct international cooperation activities with the
U.N., JICA, local government and NGOs in developing countries. Our educational activities provide
practical trainings for students, who are enthusiastic about contributing to research in international
health and to international cooperation.

• Health promotion in developing countries• Health and human rights• Conflicts and health• School health• Infectious diseases (HIV/AIDS, TB, Malaria etc.)• Nutrition• Health policy and its impact on health of community people• Global health workforce policy

50

Human Genetics ——————————————————————————————————————————————
http://www.humgenet.m.u-tokyo.ac.jp/

Department of Human Genetics is broadly interested in the human genome diversity, especially in
the Asian populations. Specifically, we are using genomic research tools including SNP andmicrosatellite analyses, as well as gene expression profiling, to better understand the genetic background of a variety of complex diseases, especially bone and joint diseases, infectious diseases andsleep disorders.

• Theoretical and experimental analyses on the genetics of complex diseases• Development of statistical approaches for susceptibility gene mapping in complex diseases• Comprehensive genetics of bone and joint diseases• Host susceptibility factors to infectious diseases• Molecular mechanisms of sleep disorders• Development of new methodologies for genomic polymorphism and gene
expression analyses• Analysis on the genome diversity of Asia-Pacific populations• Development of methodologies for the analysis of protein interactions
Tools for genomic analyses

Developmental Medical Sciences —————————————————————————————————
Founded in 1966 as the Department of Maternal and Child Health, this department has devoted
itself to the research and education on the maintenance and promotion of mothers' and children's
health, including studies of infectious diseases, nutritional disorders and congenital anomalies. At
present, the main research activities are experimental and epidemiological studies on the etiology(genetic and environmental factors), pathogenesis, prevention and treatment of various childhood
brain disorders (congenital and acquired) that cause mental and motor disabilities and epilepsy,
from the viewpoint of international health science and developmental neuroscience.

• Studies on developmental brain disorders• Abnormal neuronal differentiation and size control (tuberous sclerosis)• Neuronal migration disorders (lissencephaly, polymicrogyria)• Perinatal brain injury (periventricular leukomalacia)• Postnatal brain injury (acute encephalopathy)• Inherited metabolic disorders (peroxisomal and mitochondrial disorders)• Molecular epidemiology of infectious diseases (diarrheal viruses)• Field studies of maternal and child health (malnutrition, obesity)

Time- and space-specific expression of doublecortin,a protein regulating neuronal migration

Human Ecology ——————————————————————————————————————————————
http://www.humeco.m.u-tokyo.ac.jp/

Ecological understanding of health and survival of contemporary human populations through theanalyses of nutritional, demographic, and environmental aspects of each population is our primarygoal. Both fieldworks on various Asia-Oceania populations as well as experimental studies dealing
with nutrition and environmental chemicals are conducted, which would serves as the basis in challenging the International Health issues.

• Mechanistic analyses of the effect of subsistence transitions on the healthand environment in rural and urban communities in developing countries• Application of GPS, GIS, and remote sensing to health ecology and inter-national health• Exposure-effects evaluation of chemical pollution of watershed in rural
Indonesian children• Nutritional ecology, subsistence ecology, medical anthropology and biologicaldemography in Asia-Oceania populations• Development effects of perinatal exposures to heavy metals, pesticides, or
endocrine disrupting chemicals• Modulating effects of nutrients and nutritional status on environmental
hazardous chemicals• Sustainable society and health

At a school in a survey area, West Java, Indonesia

51

Biomedical Chemistry ——————————————————————————————————————————
The aim of our department is to contribute to the overall global health and welfare through basic
research. Our current interests are: the energy metabolism of humans, parasites, and bacteria; andRNA and RNA-binding proteins.

• Human succinate dehydrogenase complex and mitochondrial myopathy• Ascaris suum and Caenorhabditis elegans• Molecular mechanism of adaptation to low oxygen tension• Mitochondrial quinol-fumarate reductase• C. elegans as a model system of parasitic nematodes and ageing• Malaria and Trypanosome: characterization of mitochondria as a target
for chemotherapy• Escherichia coli and Mycobacterium: respiratory enzymes and regulation of energy supply• RNA and RNA-binding proteins• Mitochondriral translation system• RNA biogenesis of Eukarya and Archaea

52

Free-living nematode Caenorhabditis elegans expressing a
recombinant green fluorescent protein inside the bodyunder the control of the promoter of the iron-sulfur subunit(Ip) gene of succinate-ubiquinone reductase (complex II)

53

1

School of Public HealthSocial and Preventive Epidemiology ———————————————————————————————
Our main research field is preventive epidemiology on lifestyle-related diseases. This department is
unique in Japan since our core research field is "nutritional epidemiology", which epidemiologicallyexamines the roles of diets for disease prevention and control.

• Methodological studies on dietary assessments• Nutritional epidemiologic studies on nutrient

intakes/dietarybehaviors and health status• Studies on development of dietary promotion methods
andevaluation of their effectiveness• Establishment of literature database for "epidemiologic
studies on diets and health"• Collaborative studies with clinical trial groups on nutrition-related diseases

Health Economics and Epidemiology Research ———————————————————————The department purports to help students become a health service practitioner with a sound theoretical and scientific ground underscored by quantitative methods of epidemiology and economics.
The department will also contribute to the society through conducting empirical assessment ofhealth practice and policy on the themes suchas;

• Economic assessment of medical technology• Clinical evaluation through patient-derived outcome• Standardization and management of quality of care
• Health policy assessment• Health impact of socio-economic policy

Changes in the treatment strategy mix for angina pectoris,
before and after introduction of drug eluting stent.
(Research in Aid from Ministry of Health Labor and Welfare,
2008)

54

Clinical Information Engineering —————————————————————————————————
Clinical Information Engineering is a combination of information science, computer science, andclinical science designed to assist in the management and processing of data, information andknowledge to support the practice and delivery of biomedical research and clinical care.

• Medical Decision Making• Cancer informatics• Data Mining & Knowledge Discovery in Database• Virtual reality for medical science• Social information engineering for Public Health

A virtual reality application for medical decision
making55

Center for Disease Biology andIntegrative Medicine

Molecular Biomedicine for Pathogenesis ———————————————————————————
http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

Focusing on functional analysis of newly isolated genes, particularly related to apoptosis, cell differentiation, or cell cycle, our laboratory is pursuing clarification of the pathogenesis of various diseases and the related physiological machineries in cellular and molecular aspects. Based on our
technical advantage in gene manipulation via gene knockout and transgenesis, we give high priorities to in vivo analyses. Our overall goal is to apply our findings to development of novel and definitive therapies fortypes of diseases.

• Role of AIM (Apoptosis Inhibitor of Macrophage) in atherosclerosis

development and other diseases• Regulation of hematopoiesis and its relevance to leukemogenesis; via
functional analysis of a newly identified Polycomb group molecule
MBT-1• Regulation of tumorgenesis by modulating apoptosis and cell cycle;
via analysis of DEDD-deficient animals

Structual Physiology

http://www.bm2.m.u-tokyo.ac.jp/index-e.html

We have been exploring two-photon excitation microscopy,
which utilizes an infrared femtosecond-pulsed laser as alight source, to visualize and stimulate intact tissues at thecellular and molecular levels. We focus on the functions
and disorders of the brain and secretory organs.

• The dynamics of synapses in the cerebral cortex, in relation to memory, cognitive processes and mental disorders• Molecular mechanisms of exocytosis in synapses and the islet of
Langerhans, and their optical control

Fine structure and function of a central neuron studied with two-photon excitation imaging anduncaging

56

Regenerative Medical Engineering ———————————————————————————————
http://www.cdbim.m.u-tokyo.ac.jp/

We aim to create a basic methodology for tissue engineering by integrating engineering sciences such as mechanical, material, and chemical system engineering into basic and clinical medicine. Especially forthe regeneration of bones, cartilages, and blood vessels, we focus on
cellular response to physical stimulations, which can be utilized
instead of growth factors and cytokines. Besides, we focus on peritoneum as a place for in vivo tissue regeneration. Development of new
biomaterials such as porous materials, hydrogels, molecular signalresponsive materials is also one of our major missions.

• Development of new polymeric and inorganic biomaterials for regenerative

Ushida Lab

Ito Labmedicine• In vitro regeneration of carriages, bones, and small blood vessels• Mechanism of cellular response to physical stimulations• Development of new polymeric biomaterials for peritoneal diseases• Mathematical system design for tissue regeneration process• Development of molecular signal-responsive materials for a medical use

Clinical Biotechnology —————————————————————————————————————————
http://www.bmw.t.u-tokyo.ac.jp/english/index.html http://park.itc.u-tokyo.ac.jp/NBEP/index-en.html http://square.umin.ac.jp/t-e/Nanodevices produced by nanotechnology integrate materials and systems on a nanometer scale,and hold the key to realizing the futuristic medical system that can serve the needed function at
the right time and the right place with minimal invasiveness. Furthermore, nanodevices are expected to become an important interface between basic biomedical science and clinical medicine byfacilitating the translation of basic achievements into clinical applications. Our division wishes to produce revolutionary medical nanodevices based on nanotechnology and thereby to spread the idea of“Nanomedicine” intranationally and internationally.

• Development of nano-scaled carriers of drugs and genes based on polymeric micelles• Functional diagnostic imaging• Pinpoint cancer therapy• Gene therapy• Development of functional polymeric micelles responsive to external stimuli• Development of functional cell arrays based on nano-fabrication of polymers• Development of intelligent scaffolds delivering drugs and genes and their application to regenerative medicine

Environmental Health Sciences ———————————————————————————————————
http://env-health.m.u-tokyo.ac.jp/english/index.html

Children’s health problems of today include such conditions as disorders in the reproductive andimmune functions, learning deficits, mental problem and ‘metabolic syndrome’. Our research is carried out on the recognition that the homeostasis is disrupted by various environmentally hazardous
chemicals, to which expectant mothers and their newborn babies are exposed during their highly
sensitive period of life, and that the contamination with these chemicals may lead to various disease conditions in children after birth. Our experimental
investigations are focused on the following themes.

• Elucidation of mechanisms involved in the manifestation of toxicity

at the molecular and cellular level due to exposure to environmental
pollutants, such as dioxin/PCBs and heavy metals.
• Clarification of epigenetic mechanisms that alter susceptibility toenvironmental chemicals.
• Development of methodologies for evaluating the toxicity of chemicals to the learning and emotion of rodents and of in vitro toxicity
techniques at the molecular and cellular levels.
• Development and application of techniques and methodology forevaluating risks of toxic substances in formulating safety standard
for the environment and food.

57

Animal Resources / Research Resources and Support - Animal Research ————
Our laboratory focuses on understanding the molecular mechanisms which underlie the synaptic
plasticity, activity dependent formation of neuronal circuitry, and learning and memory. We generate knockout mice and inducible knockout mice of signal transduction molecules including the glutamate receptors. We also manage the animal facilities, give researchers advice on their animal
experiments, and give lectures on laboratory animal science so that animal experiments are carriedout in consideration of animal welfare.

• Molecular analysis of brain function using genetically modified mice
• Development of new reproductive technologies in mammals• Development of model animals for signal transduction diseases

A mutant mouse lacking metabotropic glutamate receptor subtype-1 (mGluR1).

Molecular Radiology / Research Resources and Support - Radiation Biology ——http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

We are investigating the molecular mechanisms of DNA double-strand break repair as the scientificbasis of radiation therapy and chemotherapy in medical oncology. We also promote the basic
research that contributes to the development of a novel
therapeutic strategy by examining a link of the DNA
metabolic network including DNA replication and cell
cycle control with chromosome instability.

• Molecular mechanisms of homologous recombinational repair• Mechanisms of the choice between homologous recombination andnon-homologous end-joining• Molecular mechanisms of DNA rereplication• Mechanisms of the genesis of aneuploidy• Functional analysis of meiotic recombination genes

Centrosome fragmentation which may lead to aneuploidy

Research Resources and Support - Bioinformatics —————————————————————
http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

Targeting biomedical research support using information
technologies, the division performs management of theresearch network and the central servers of the Graduate
School of Medicine, and researches on knowledge infrastructure and processing techniques (e.g. information
model, ontology, natural language processing, machinereasoning, etc.) and their application to clinical practice.

• Biomedical research support using network system• Medical terminologies and ontologies• Standardization of healthcare information and information models• Natural language processing and its application to the medical
domain• Machine reasoning and clinical decision support systems

Computer System for Biomedical Research

58Pharmacy

Pharmaceutical Services ————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/yakuzai.html

Our goal is to provide optimized pharmacotherapy for each patient, based on the analysis and prediction of individual pharmacokinetics, drug sensitivity and drug adverse reaction.
We are now advancing the basic study of the regulatory mechanism of gene function and gene expression, paticularly focusing on the molecules related to osteoporosis and lifestyle diseases, as well as clinical application of genetic polymorphism analysis of drug metabolizing
enzymes and drug transporters.

• Analysis of genotype and phenotype of drug metabolizing enzymes and drugtransporters• Strategies for accurate prediction of drug disposition, and pharmacokinetic/
pharmacodynamic (PK/PD) studies• Transporters involved in lipid homeostasis• Regulatory mechanisms of signaling molecules involved in bone homeostasis• Basic and clinical approach to prevent and cure drug induced liver injury
Therapentic drug monitoring59

1Central Clinical Facilities

Clinical Laboratory ————————————————————————————————————————————
http://lab-tky.umin.jp/

Our main duty is to provide the high-quality results of laboratory tests. We also emphasize the basic
research on laboratory automation and standardization, development and improvement of laboratory tests, and pathophysiological analyses through laboratory tests, as follows.

• Laboratory automation system• Clinical application of genetic analysis of leukemia and drug response
genes• Analysis of bioactive substances, and its application to laboratory

medicine• Analysis of the cardiac functions using ultrasound• Relationship between the respiratory function and various pathophysiological conditions• Investigation of brain function using magnetoencephalography
Laboratory automation system

Surgical Center ——————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/syujutsu.html

Operating rooms were centralized as a surgical center for the first time in Japan, in the surgical ward building of University of Tokyo Hospital on July 1955. The surgical center moved to the new central building on
January 1988. In July 2001,the branch hospital of our university located in Mejiro was closed and joined to
our University Hospital located in Hongo. Furthermore, a new ward building was opened in October 2001.
Since then, the number of operations has been remarkably increasing. Another new central building
including new operating rooms will be constructed in fall 2006. A total of 9,868 operations were performedin the year 2008.
Teaching activities include lectures to the undergraduate and postgraduate medical students as well as
nursing staffs and medical electronics engineers, regarding aseptic techniques, sterilization methods, disinfecion methods, prevention of perioperative infections, humoral and cellular responses to trauma andshock, training of handwashing and gown techniques.

• Safety management in the operating rooms• Efficient management of the operating rooms• Cleaning, Disinfection and Sterilization• Environmental control in the operating rooms• Improvement of cost-effectiveness in the management of surgical center• Perioperative infection control• Precautions of accidental troubles in handling surgical instruments and medical devises• Development of new surgical instruments and medical devises• Three-dimensional processing of visual information
60

University hospital Medical Information Network Center (UMIN Center) ———————
http://www.umin.ac.jp/english/

UMIN is the largest and most versatile academic medical information center in the world with 300 thousands registered medical
professionals and 50 million pages per view monthly web accesses
UMIN is managed by the UMIN Council under the National
University Hospital Association.

• Major information services• Electronic Library for Biomedical Sciences (ELBIS)• Internet Data and Information Center for clinical and epidemiological research(INDICE)• Evaluation system of Postgraduate Clinical training (EPOC)• Dental training Evaluation and taBUlation sysTem(Debut)• Major research activities• Health communication• Science communication• Information systems for clinical and epidemiological research• Network security

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Center

The International Research Center for Medical Education ———————————————
http://www.ircme.u-tokyo.ac.jp/

The International Research Center for Medical Education is a research institute to develop andimprove medical education (including other health professional education) domestically and internationally. We implement innovative curricula for the Faculty of Medicine and invite overseas
experts to provide updated information about medical education. We also manage international
cooperation projects and produce a research hub in medical education field in Asian region such as
Afghanistan and Lao P. D. R.

PBL class in Kabul Medical University, Afghanistan

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Nurce Dormitory

East ClinicalResearch Bldg

ClinicalResearchCenterInpatients' Ward B

ClinicalAmphiteater

Inpatients'
Ward ARI Bldg.

Old

Hospital Central Clinical
Service Bldg.

First
Research
Bldg.

CentralClinical Service
Bldg. 1
CentralClinical Service
Bldg. 2Administration &Research Bldg.

Tetsumon Gate

Facility Center
Bldg.
No.4

Outpatient
Clinical Bldg.

South ClinicalResearch Bldg

MedicalLibrary
International
ResearchCenter for
Medical
Education
International
ResearchCenterBldg. No.2

Center for Disease
Biology andIntegrative
Medicine
Bldg.
No.3
Experimental Research Bldg.

Bldg. No.1

Kaitokumon
Gate(Akamon Gate)

Bldg.
No.5

Kasugamon
Gate
Annex of
Bldg.
No.3

Takao Shimizu
Dean, Faculty of Medicine, Graduate School of Medicine
The University of Tokyo
Address:7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
http://www.m.u-tokyo.ac.jp

Issued on Nov. 1, 2009