Tokyo University of Agriculture and Technology

Institute of Global Innovation Research

グローバルイノベーション研究院 公開セミナー
Institute of Global Innovation Research Open Seminar

Investigating the mechanism of RNA
genome packaging of Rift Valley Fever
Phlebovirus

Dr. Shinji Makino
Professer, Department of Microbiology and Immunology,
The University of Texas Medical Branch at Galveston, USA

Tuesday

March 10, 2020
10:30 〜 11:30■会場／Venue

東京農工大学 府中キャンパス
新4号館

4階

451号室

Room 451, 4th Fl., New Building 4 ,Fuchu Campus, TUAT
府中キャンパス
Fuchu Campus

正門
Main Gate

北門
North Gate

講演会場 /Venue

南門
South Gate

■共催／Co-Organized by
グローバルイノベーション研究院
ライフサイエンス分野 水谷チーム
Institute of Global Innovation“Life Science” Mizutani Team
卓越大学院プログラム
Excellent Leader Development forSuper Smart Society
by New Industry Creation and Diversity

ABSTRACT

Rift Valley fever phlebovirus (RVFV), a bunyavirus, causes a disease that isendemic in sub-Saharan Africa and can emerge in explosive,mosquito-borne epidemics that decimate herds of sheep and cattle,
resulting in enormous economic losses. In humans, RVFV infection may
cause hemorrhagic fever, encephalitis, and retinal vasculitis. Manydiﬀerent mosquitoes, including several species native to North America,are competent vectors for RVFV transmission. The introduction of RVFV
into other regions, including North America, would likely cause panic in
the general population, and the eﬀects on livestock could have adevastating economic impact. The lack of availability of licensed vaccines
or anti-RVFV reagents for use in humans or domestic animals is of great
concern. RVFV carries a tripartite, single-stranded, negative-sense RNAgenome. One of the essential steps in virus replication and disseminationis the packaging of viral genome into virus particles, however, themechanisms of viral RNA packaging in RVFV and other bunyaviruses arelargely unknown. Insight into the underlying rules and mechanisms thatgovern the packaging of viral RNA genome into RVFV particles is valuable
for understanding the regulation of virus replication, virus evolution, andthe pathogenesis of the virus. This knowledge is also critical for thedevelopment of antiviral drugs that can inhibit infectious virus
production or for the development of a live- attenuated vaccine strain.
Our data demonstrated that a direct interaction of a viral envelop protein,Gn, with the viral RNA segments is the primary factor that inﬂuences thepackaging eﬃciencies of viral RNAs into RVFV particles. Our recent dataalso suggest importance of viral nucleocapsid protein for co-packaging ofviral RNAs. We hope that these data will clarify the fundamental
mechanisms that drive viral RNA packaging in RVFV and otherbunyaviruses, with the overall goal of informing the design of novel
antivirals and vaccines.

■お問合せ先／Contact
グローバルイノベーション研究院 農学研究院 水谷 哲也
Institute of Global Innovation Research, Institute of Agriculture,
Prof. Tetsuya Mizutani
Email: tmizutan(ここに@を入れてください) cc.tuat.ac.jp
本セミナーは、参加者を制限して開催し、後日、Google Classroom にて配信します。
Online distribution by Google Classroom later

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言語 / 日本語・ Language / Japanese
関連する教員のみご参加頂けます。
For involved faculties only.

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