Top論文1%論文（1996-2009年）※
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Year

JournalVolume Issue

Pages

Matsuo, S; Imai, E; Horio, M; Yasuda, Y; Tomita, K; Nitta, K; Yamagata, K;
Tomino, Y; Yokoyama, H; Hishida, A

Revised Equations for Estimated GFR From Serum Creatinine in Japan2009

AMERICAN JOURNAL OF KIDNEYDISEASES

53

6 982-992

Kodama, S; Saito, K; Tanaka, S; Maki, M; Yachi, Y; Asumi, M; Sugawara, A;
Totsuka, K; Shimano, H; Ohashi, Y; Yamada, N; Sone, H

Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause
Mortality and Cardiovascular Events in Healthy Men and Women A
Meta-analysis

JAMA - JOURNAL OF THE
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301

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Satake, W; Nakabayashi, Y; Mizuta, I; Hirota, Y; Ito, C; Kubo, M; Kawaguchi, T;
Tsunoda, T; Watanabe, M; Takeda, A; Tomiyama, H; Nakashima, K; Hasegawa, K; Genome-wide association study identifies common variants at four loci
Obata, F; Yoshikawa, T; Kawakami, H; Sakoda, S; Yamamoto, M; Hattori, N;
as genetic risk factors for Parkinson's disease
Murata, M; Nakamura, Y; Toda, T2009 NATURE GENETICS

41

1213031307

Kirkin, V; Lamark, T; Sou, YS; Bjorkoy, G; Nunn, JL; Bruun, JA; Shvets, E;
McEwan, DG; Clausen, TH; Wild, P; Bilusic, I; Theurillat, JP; Overvatn, A; Ishii,
T; Elazar, Z; Komatsu, M; Dikic, I; Johansen, T2009 MOLECULAR CELL

33

4 505-516

Kato, M., Putta, S., Wang, M., Yuan, H., Lanting, L., Nair, I., Gunn, A., Nakagawa, TGF-β activates Akt kinase through a microRNA-dependent amplifying
Y., Shimano, H., Todorov, I., Rossi, J.J., Natarajan, R.
circuit targeting PTEN

2009 Nature Cell Biology

11

7 881-889

The antioxidant defense system Keap1-Nrf2 comprises a multiple
Kobayashi, M., Li, L., Iwamoto, N., Nakajima-Takagi, Y., Kaneko, H., Nakayama,
sensing mechanism for responding to a wide range of chemical
Y., Eguchi, M., Wada, Y., Kumagai, Y., Yamamoto, M.
compounds

2009 Molecular and Cellular Biology

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2 493-502

Sanada, M., Suzuki, T., Shih, L.-Y., Otsu, M., Kato, M., Yamazaki, S., Tamura, A.,
Honda, H., Sakata-Yanagimoto, M., Kumano, K., Oda, H., Yamagata, T., Takita, J.,
Gain-of-function of mutated C-CBL tumour suppressor in myeloid
Gotoh, N., Nakazaki, K., Kawamata, N., Onodera, M., Nobuyoshi, M., Hayashi, Y.,neoplasms
Harada, H., Kurokawa, M., Chiba, S., Mori, H., Ozawa, K., Omine, M., Hirai, H.,
Nakauchi, H., Koeffler, H.P., Ogawa, S.

2009 Nature

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Imai, E., Horio, M., Watanabe, T., Iseki, K., Yamagata, K., Hara, S., Ura, N.,
Kiyohara, Y., Moriyama, T., Ando, Y., Fujimoto, S., Konta, T., Yokoyama, H.,
Makino, H., Hishida, A., Matsuo, S.

Prevalence of chronic kidney disease in the Japanese general population2009 Clinical and Experimental Nephrology

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6 621-630

Homma, S; Ishii, Y; Morishima, Y; Yamadori, T; Matsuno, Y; Haraguchi, N;
Kikuchi, N; Satoh, H; Sakamoto, T; Hizawa, N; Itoh, K; Yamamoto, M

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in
Human Lung Cancer

2009 CLINICAL CANCER RESEARCH

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A Role for NBR1 in Autophagosomal Degradation of UbiquitinatedSubstrates

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Kodama, S., Saito, K., Yachi, Y., Asumi, M., Sugawara, A., Totsuka, K., Saito, A.,
Association between serum uric acid and development of type 2 diabetes
Sone, H.

2009 Diabetes Care32

9Ng, M.Y.M., Levinson, D.F., Faraone, S.V., Suarez, B.K., Delisi, L.E., Arinami, T.,
Riley, B., Paunio, T., Pulver, A.E., Irmansyah, , Holmans, P.A., Escamilla, M.,
Wildenauer, D.B., Williams, N.M., Laurent, C., Mowry, B.J., Brzustowicz, L.M.,
Maziade, M., Sklar, P., Garver, D.L., Abecasis, G.R., Lerer, B., Fallin, M.D.,
Gurling, H.M.D., Gejman, P.V., Lindholm, E., Moises, H.W., Byerley, W.,
Wijsman, E.M., Forabosco, P., Tsuang, M.T., Hwu, H.-G., Okazaki, Y., Kendler,
K.S., Wormley, B., Fanous, A., Walsh, D., O'Neill, F.A., Peltonen, L., Nestadt, G.,
Lasseter, V.K., Liang, K.Y., Papadimitriou, G.M., Dikeos, D.G., Schwab, S.G.,
Meta-analysis of 32 genome-wide linkage studies of schizophrenia
Owen, M.J., O'Donovan, M.C., Norton, N., Hare, E., Raventos, H., Nicolini, H.,
Albus, M., Maier, W., Nimgaonkar, V.L., Terenius, L., Mallet, J., Jay, M., Godard,S., Nertney, D., Alexander, M., Crowe, R.R., Silverman, J.M., Bassett, A.S., Roy,
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T., Petursson, H., Sanders, A.R., Duan, J., Jazin, E., Myles-Worsley, M.,
Karayiorgou, M., Lewis, C.M.

2009 Molecular Psychiatry

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Lakshmikanth, T., Burke, S., Ali, T.H., Kimpfler, S., Ursini, F., Ruggeri, L.,
Capanni, M., Umansky, V., Paschen, A., Sucker, A., Pende, D., Groh, V., Biassoni, NCRs and DNAM-1 mediate NK cell recognition and lysis of human andR., H?glund, P., Kato, M., Shibuya, K., Schadendorf, D., Anichini, A., Ferrone, S., mouse melanoma cell lines in vitro and in vivo
Velardi, A., K?rre, K., Shibuya, A., Carbone, E., Colucci, F.

2009 Journal of Clinical Investigation

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Ishii, K.-A., Fumoto, T., Iwai, K., Takeshita, S., Ito, M., Shimohata, N., Aburatani, Coordination of PGC-1β and iron uptake in mitochondrial biogenesis andH., Taketani, S., Lelliott, C.J., Vidal-Puig, A., Ikeda, K.
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Ohta, T., Iijima, K., Miyamoto, M., Nakahara, I., Tanaka, H., Ohtsuji, M., Suzuki,
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2008 Cancer Research

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Saito, D., Sugimura, H., Tanioka, F., Kato, S., Matsukura, N., Matsuda, N.,
Nakamura, T., Hyodo, I., Nishina, T., Yasui, W., Hirose, H., Hayashi, M., Toshiro,
Genetic variation in PSCA is associated with susceptibility to diffuseE., Ohnami, S., Sekine, A., Sato, Y., Totsuka, H., Ando, M., Takemura, R.,
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Takahashi, Y., Ohdaira, M., Aoki, K., Honmyo, I., Chiku, S., Aoyagi, K., Sasaki,
H., Ohnami, S., Yanagihara, K., Yoon, K.-A., Kook, M.-C., Lee, Y.-S., Park, S.R.,
Kim, C.G., Choi, I.J., Yoshida, T., Nakamura, Y., Hirohashi, S.

2008 Nature Genetics

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Makuuchi, M., Kokudo, N., Arii, S., Futagawa, S., Kaneko, S., Kawasaki, S.,
Matsuyama, Y., Okazaki, M., Okita, K., Omata, M., Saida, Y., Takayama, T.,
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2008 Hepatology Research38

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Development of evidence-based clinical guidelines for the diagnosis andtreatment of hepatocellular carcinoma in Japan

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Yamamoto, T., Suzuki, T., Kobayashi, A., Wakabayashi, J., Maher, J., Motohashi,
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Physiological significance of reactive cysteine residues of Keap1 indetermining Nrf2 activity

2008 Molecular and Cellular Biology

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Orexin neuronal circuitry: Role in the regulation of sleep andwakefulness

2008 Frontiers in Neuroendocrinology

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Hotta, K., Nakata, Y., Matsuo, T., Kamohara, S., Kotani, K., Komatsu, R., Itoh, N.,
Mineo, I., Wada, J., Masuzaki, H., Yoneda, M., Nakajima, A., Miyazaki, S.,
Variations in the FTO gene are associated with severe obesity in the
Tokunaga, K., Kawamoto, M., Funahashi, T., Hamaguchi, K., Yamada, K.,
Japanese
Hanafusa, T., Oikawa, S., Yoshimatsu, H., Nakao, K., Sakata, T., Matsuzawa, Y.,
Tanaka, K., Kamatani, N., Nakamura, Y.

2008 Journal of Human Genetics

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Obayashi, E., Yoshida, H., Kawai, F., Shibayama, N., Kawaguchi, A., Nagata, K.,
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The structural basis for an essential subunit interaction in influenza virus
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2008 Nature

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Ishii, W., Ito, S., Kondo, Y., Tsuboi, H., Mamura, M., Goto, D., Matsumoto, I.,
Tsutsumi, A., Sumida, T., Okoshi, Y., Hasegawa, Y., Kojima, H., Sakashita, S.,
Aita, K., Noguchi, M.

Intravascular large B-cell lymphoma with acute abdomen as a presenting
symptom in a patient with systemic lupus erythematosus

2008 Journal of Clinical Oncology

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Sakurai, T.

The neural circuit of orexin (hypocretin): Maintaining sleep andwakefulness

2007 Nature Reviews Neuroscience8

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Imai, E., Horio, M., Nitta, K., Yamagata, K., Iseki, K., Hara, S., Ura, N., Kiyohara,Y., Hirakata, H., Watanabe, T., Moriyama, T., Ando, Y., Inaguma, D., Narita, I.,
Estimation of glomerular filtration rate by the MDRD study equation
Iso, H., Wakai, K., Yasuda, Y., Tsukamoto, Y., Ito, S., Makino, H., Hishida, A.,
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Matsuo, S.

2007 Clinical and Experimental Nephrology

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Itoh, S., ten Dijke, P.

Negative regulation of TGF-β receptor/Smad signal transduction

2007 Current Opinion in Cell Biology

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Matsuzaka, T., Shimano, H., Yahagi, N., Kato, T., Atsumi, A., Yamamoto, T.,
Inoue, N., Ishikawa, M., Okada, S., Ishigaki, N., Iwasaki, H., Iwasaki, Y.,
Karasawa, T., Kumadaki, S., Matsui, T., Sekiya, M., Ohashi, K., Hasty, A.H.,
Nakagawa, Y., Takahashi, A., Suzuki, H., Yatoh, S., Sone, H., Toyoshima, H.,
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Crucial role of a long-chain fatty acid elongase, Elovl6, in obesityinduced insulin resistance2007 Nature Medicine

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2007 FASEB Journal

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Imai, E., Horio, M., Iseki, K., Yamagata, K., Watanabe, T., Hara, S., Ura, N.,
Prevalence of chronic kidney disease (CKD) in the Japanese general
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2007 Clinical and Experimental Nephrology

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Maher, J.M., Dieter, M.Z., Aleksunes, L.M., Slitt, A.L., Guo, G., Tanaka, Y.,
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2007 Hepatology

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Kodama, S., Tanaka, S., Saito, K., Shu, M., Sone, Y., Onitake, F., Suzuki, E.,
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Effect of aerobic exercise training on serum levels of high-density
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Kumagai, Y., Sumi, D.

Arsenic: Signal transduction, transcription factor, and biotransformation
involved in cellular response and toxicity

2007

Itoh, A., Ueno, E., Tohno, E., Kamma, H., Takahashi, H., Shiina, T., Yamakawa,M., Matsumura, T.

Breast disease: Clinical application of US elastography for diagnosis

Kobayashi, A., Kang, M.-I., Watai, Y., Tong, K.I., Shibata, T., Uchida, K.,
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2006 Radiology

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2006 Molecular and Cellular Biology

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2006 Journal of Clinical Investigation

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2006 Advances in Enzyme Regulation46

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Padmanabhan, B., Tong, K.I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Structural basis for defects of Keap1 activity provoked by its point
Kang, M.-I., Kobayashi, A., Yokoyama, S., Yamamoto, M.
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2006 Molecular Cell

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Iso, H., Kobayashi, M., Ishihara, J., Sasaki, S., Okada, K., Kita, Y., Kokubo, Y.,
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Intake of fish and n3 fatty acids and risk of coronary heart disease among
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2006 Circulation

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Narita, M., Nagumo, Y., Hashimoto, S., Narita, M., Khotib, J., Miyatake, M.,
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Direct involvement of orexinergic systems in the activation of themesolimbic dopamine pathway and related behaviors induced bymorphine

2006 Journal of Neuroscience26

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Nrf2-Keap1 regulation of cellular defense mechanisms againstelectrophiles and reactive oxygen species

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Onaivi, E.S., Ishiguro, H., Gong, J.-P., Patel, S., Perchuk, A., Meozzi, P.A., Myers,
Discovery of the presence and functional expression of cannabinoid CB2
L., Mora, Z., Tagliaferro, P., Gardner, E., Brusco, A., Akinshola, B.E., Liu, Q.-R.,
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Hope, B., Iwasaki, S., Arinami, T., Teasenfitz, L., Uhl, G.R.

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Irie, F., Iso, H., Sairenchi, T., Fukasawa, N., Yamagishi, K., Ikehara, S., Kanashiki, The relationships of proteinuria, serum creatinine, glomerular filtration
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2006 Kidney International

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Tong, K.I., Katoh, Y., Kusunoki, H., Itoh, K., Tanaka, T., Yamamoto, M.

Keap1 recruits Neh2 through binding to ETGE and DLG motifs:
Characterization of the two-site molecular recognition model

2006 Molecular and Cellular Biology

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McMahon, M., Thomas, N., Itoh, K., Yamamoto, M., Hayes, J.D.

Dimerization of substrate adaptors can facilitate Cullin-mediatedubiquitylation of proteins by a "tethering" mechanism: A two-site
interaction model for the Nrf2-Keap1 complex

2006 Journal of Biological Chemistry

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Two-site substrate recognition model for the Keap1-Nrf2 system: A
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2006 Biological Chemistry

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Okawa, H., Motohashi, H., Kobayashi, A., Aburatani, H., Kensler, T.W.,
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Hepatocyte-specific deletion of the keap1 gene activates Nrf2 andconfers potent resistance against acute drug toxicity

2006

Miharada, K., Hiroyama, T., Sudo, K., Nagasawa, T., Nakamura, Y.

Efficient enucleation of erythroblasts differentiated in vitro fromhematopoietic stem and progenitor cells

Nakagawa, Y., Shimano, H., Yoshikawa, T., Ide, T., Tamura, M., Furusawa, M.,
Yamamoto, T., Inoue, N., Matsuzaka, T., Takahashi, A., Hasty, A.H., Suzuki, H.,
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Biochemical and Biophysical ResearchCommunications339

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2006 Nature Biotechnology

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TFE3 transcriptionally activates hepatic IRS-2, participates in insulin
signaling and ameliorates diabetes

2006 Nature Medicine

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Molecular mechanisms activating the Nrf2-Keap1 pathway ofantioxidant gene regulation2005 Antioxidants and Redox Signaling

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Rangasamy, T., Guo, J., Mitzner, W.A., Roman, J., Singh, A., Fryer, A.D.,
Yamamoto, M., Kensler, T.W., Tuder, R.M., Georas, S.N., Biswal, S.

Disruption of Nrf2 enhances susceptibility to severe airway inflammation
and asthma in mice2005 Journal of Experimental Medicine

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Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y.,
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Input of orexin/hypocretin neurons revealed by a genetically encoded
tracer in mice2005 Neuron

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2005 Molecular and Cellular Biology

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Sugiura, S., Oda, T., Izumida, Y., Aoyagi, Y., Satake, M., Ochiai, A., Ohkohchi, N., Size control of calcium alginate beads containing living cells using
Nakajima, M.
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Kaji, Y., Hu, B., Kawana, K., Oshika, T.

Swimming with soft contact lenses: Danger of acanthamoeba keratitis

2005 Lancet Infectious Diseases

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Weening, J.J., D'Agati, V.D., Schwartz, M.M., Seshan, S.V., Alpers, C.E., Appel,
G.B., Balow, J.E., Bruijn, J.A., Cook, T., Ferrario, F., Fogo, A.B., Ginzler, E.M.,
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The Classification of Glomerulonephritis in Systemic Lupus
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Yagi, H., Nomura, T., Nakamura, K., Yamazaki, S., Kitawaki, T., Hori, S., Maeda, Crucial role of FOXP3 in the development and function of humanM., Onodera, M., Uchiyama, T., Fujii, S., Sakaguchi, S.
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2004 International Immunology

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Rangasamy, T., Cho, C.Y., Thimmulappa, R.K., Zhen, L., Srisuma, S.S., Kensler,
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Genetic ablation of Nrf2 enhances susceptibility to cigarette smokeinduced emphysema in mice

2004 Journal of Clinical Investigation

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A transposon-mediated gene trap approach identifies developmentally
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2004 Developmental Cell

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Itoh, K., Tong, K.I., Yamamoto, M.

Molecular mechanism activating Nrf2-Keap1 pathway in regulation ofadaptive response to electrophiles

2004 Free Radical Biology and Medicine

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MafA is a key regulator of glucose-stimulated insulin secretion

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3
K., Yamamoto, M.
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Motohashi, H., Yamamoto, M.

Nrf2-Keap1 defines a physiologically important stress response
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Ishida, J., Hashimoto, T., Hashimoto, Y., Nishiwaki, S., Iguchi, T., Harada, S.,
Sugaya, T., Matsuzaki, H., Yamamoto, R., Shiota, N., Okunishi, H., Kihara, M.,
Regulatory roles for APJ, a seven-transmembrane receptor related to
Umemura, S., Sugiyama, F., Yagami, K.-I., Kasuya, Y., Mochizuki, N., Fukamizu, angiotensin-type 1 receptor in blood pressure in vivoA.

2004 Journal of Biological Chemistry

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2004 Journal of Neuroscience24501143911448

Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V.,
Sekizawa, K., Uchida, K., Yamamoto, M.

Transcription Factor Nrf2 Regulates Inflammation by Mediating theEffect of 15-Deoxy-Δ12,14-Prostaglandin J2

2004 Molecular and Cellular Biology

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Ishii, T., Itoh, K., Ruiz, E., Leake, D.S., Unoki, H., Yamamoto, M., Mann, G.E.

Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in
Murine Macrophages: Activation by Oxidatively Modified LDL and 4Hydroxynonenal

2004 Circulation Research

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Sumazaki, R., Shiojiri, N., Isoyama, S., Masu, M., Keino-Masu, K., Osawa, M.,
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Conversion of biliary system to pancreatic tissue in Hes1-deficient mice

2004 Nature Genetics

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2003 Neuron

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McMahon, M., Itoh, K., Yamamoto, M., Hayes, J.D.

Keap1-dependent proteasomal degradation of transcription factor Nrf2
contributes to the negative regulation of antioxidant response elementdriven gene expression

2003 Journal of Biological Chemistry

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Kwak, M.-K., Wakabayashi, N., Itoh, K., Motohashi, H., Yamamoto, M., Kensler,
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Modulation of gene expression by cancer chemopreventive
dithiolethiones through the Keap1-Nrf2 pathway: Identification of novel
gene clusters for cell survival

2003 Journal of Biological Chemistry

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2
activation

2003 Nature Genetics

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Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O'Connor, T., Yamamoto, M.

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of
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2003 Genes to Cells

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