The University of Tokyo
Faculty of Medicine
Graduate School of Medicine

PROSPECTUS
2011—2012

A Message From the Dean of Faculty and Graduate
School of Medicine, the University of Tokyo
Faculty of Medicine, the University of Tokyo was established in 1858, and in May of 2008
we celebrated the 150th anniversary of our founding. University Executives, faculty members,
staff, and students came together for an impressive birthday ceremony, and a studentdesigned monument was installed in front of our main building. To mark the occasion, we
also established the Museum of Health and Medicine in 2011. In addition, we are planning torenovate our clinical amphitheater and lecture rooms.
With its history and traditions in mind, we must move Faculty of Medicine, theUniversity of Tokyo continuously forward. Each year in our Faculty, some 100 to 110 students
begin medical school and about 40 are admitted to School of Integrated Health Sciences(School of Health Sciences and Nursing until 2009). Also, through our highly competitive
PhD-MD program and the Medical Scientist Training Program that we began in 2008, several
outstanding medical students have already taken their first steps on the road to research
careers. In 2010, we started the Clinical Research Training Program for clinicians and students
who are interested in clinical research. Our graduate school has a wide range of programs ofstudy, and we grant from 150 to 200 doctoral degrees each year. Since its establishment in
2007, our new School of Public Health has admitted many exceptional physicians and publichealth researchers. It is also noteworthy that many students who enter our Master's degree
program in the medical sciences after graduating with Bachelor's degrees in fields other than
medicine continue their studies in our doctoral programs.
We expect that medicine will be at the center of the rapidly advancing life sciences in the
21st century. Furthermore, as we face the consequences of having an increasing number of
elderly people in our population, we know that integrated health sciences, preventive
medicine, environmental medicine, and nursing will become increasingly important. We haveinternationally prominent teachers and researchers working in a wide variety of fields, andnumerous endowed departments and social cooperation programs that embody productive
relations between academia and industry.
Through our four Global Centers of Excellence (GCOE), we support financially graduate
students and collaborative research with other graduate schools. Among our international
activities, we teach students mainly from Asia and southeast Asia but also from other regions,and we are forging new ties with universities in Europe and North America.
Thus we are involved in a broad and growing spectrum of activities: investigating thehuman body in health and disease; promoting cross-disciplinary integration at the cuttingedge of medical research and education; improving methods of diagnosis, treatment, andacute and long-term care; strengthening preventive medicine; improving hospital management
and medical services delivery; and communicating effectively in the wider social sphere.
In brief, we continue on our missions to provide the best
possible medical care to patients in need today and to train
top-level research scientists who will lay the foundations of
medicine for tomorrow.

Kohei Miyazono
Dean, Faculty and Graduate School of Medicine
The University of Tokyo

HISTORY
1858

May
Nov.

Practitioners, trained in Dutch (European) medicine in Edo (Tokyo), laid out money to establish
the Shutojo (vaccination center) in Kanda Mitamagaike.
Shutojo was destroyed in a fire that had spread from Kanda Aioicho. Shutojo continued its
operations at other sites such as the residence of Ito Genboku.

1859

Sep.

Shutojo was reconstructed at Shitaya Izumibashi Dohri.

1860

Oct.

Shutojo became an official medical institution of the Shogunate Government.

1861

Oct.

Shutojo was renamed as Seiyo Igaku-Sho (Institute of Western Medicine) and offered coursesof Western Medicine in the fields of Education, Autopsy, and Vaccination.

1863

Feb.

Seiyo Igaku-Sho was renamed as Igaku-Sho (Institute of Medicine).

1868

Jul.

Igaku-Sho, affiliated with the Military Hospital which had been moved from Yokohama to Todo
residence in Shitaya, was renamed as Daibyoin (the Great Hospital).

1869

Feb.
Dec.

The Daibyoin was renamed as Igakko-Ken-Byoin (Medical School and Hospital).
Igakko-Ken-Byoin was renamed as Daigaku Toko (University East Building).

1871

Jul.

The Ministry of Education was established and Daigaku-Toko was renamed as Toko (East
Building).

1872

Aug.

A School System was established. Toko was renamed as Daiichi-Daigaku-Ku- Igakko (The First
University District Medical School).

1874

May

Daiichi-Daigaku-Ku-Igakko was renamed as Tokyo-Igakko (Tokyo Medical School).

1876

Nov.

Tokyo-Igakko was moved to Hongo.

1877

Apr.

Tokyo Igakko, affiliated with Tokyo-Kaisei School, was renamed as The University of Tokyo.
Tokyo Medical School was renamed as The University of Tokyo Faculty of Medicine.

1886

Mar.

The University of Tokyo was renamed as Imperial University, and The University of Tokyo
Faculty of Medicine was renamed as the Imperial University Medical College. A Graduate
School was established.

1897

Jun.

The Imperial University was renamed as Tokyo Imperial University.

1917

Aug.

Eiraku Hospital, affiliated with the Ministry of Education Medical Practice License Examination,
moved to Tokyo Imperial University and was renamed as Koishikawa Hospital affiliated with
Tokyo Imperial University Medical College.

1919

Apr.

A faculty system was established renaming Tokyo Imperial University Medical College as theFaculty of Medicine.

1931

Feb.

The first building of the Faculty of Medicine was constructed.

1936

Jan.
Nov.

The Brain Research Laboratory was built with funds donated by Mr. Hisasaburo Horikoshi.
The second building of the Faculty of Medicine (main building) was constructed.

1947

Oct.

Tokyo Imperial University was renamed as The University of Tokyo.

1950

Apr.

The Institute of Nursing was renamed as The University Nursing School.

1953

Apr.
Jul.

The School of Health Care and Nursing was founded.
The Graduate School was founded, and the Division of Medical Doctor Biological Science wasestablished. The Brain Research Laboratory became the Brain Research Institute of the Facultyof Medicine.

1956

Apr.

The Midwives School was established.

1958

Apr.
May

The Division of Pharmaceutical Sciences became an independent faculty.
The University of Tokyo Faculty of Medicine celebrated its centennial anniversary.

1961

Mar.

The Medical Library was built in commemoration of the centenary.

Apr.

The Institute of Medical Electronics was established.

2

1965

Apr.

The Research Institute of Logopedics and Pediatrics was established. The School of Health Careand Nursing was reorganized as the School of Health Sciences. The Graduate School of The
University of Tokyo was reorganized and the Division of Medical Doctor Biological Science
became the Faculty of Medicine. The Health science Course was established in the Medical
Science Division.

1966

Sep.

The third building of the Faculty of Medicine was constructed.

1971

Apr.

The Laboratory of Animal Experiments was established.

1973

Mar.

The Animal Center for Biomedical Research was constructed.

1983

Jan.

An annex of the third building of the Faculty of Medicine was constructed.

1985

Sep.

The office of International Academic Affairs was established.

1987

Apr.

Specialized courses were introduced to the Graduate School of Medicine.

1992

Apr.

The School of Health Sciences became the School of Health Science and Nursing. The Schoolof International Health was established in the Medical Science Division.
The Radiation Research Institute was established.

Jul.
1995

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, four divisions,Third Basic Medicine, Social Medicine, Third and Fourth Clinical Medicine, were replaced with
Pathology, Immunology and Microbiology, Social Medicine, Reproduction and Development,
and Aging Science and Surgery.

1996

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First Clinical Medicine, Health Science, and International Health, were replaced with Internal
Medicine, Health Science and Nursing, and International Health.

1997

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First and Second Basic Medicine, and Second Clinical Medicine, were replaced with Molecular
Cell Biology, Functional Biology, Radiology and Biomedical Engineering, and Neuroscience.
As a result of the above-mentioned reorganization, three institutes, the Institute of Brain
Research, the Institute of Medical Electronics, and the Institute of Logopedics and Phoniatrics
were made redundant.

		

1999

Apr.

The Master course of Medical Science was established in the Graduate School of Medicine.
This course accepts graduates of all faculties except those from Schools of Medicine, Dentistry,and Veterinary Medicine.

2000

Apr.

The International Research Center for Medical Education was established (A shared facility foreducation and research).

2001

Apr.

The University Branch Hospital was united with the University Hospital.

2003

Apr.

The Center for Disease Biology and Integrative Medicine was established.

2004

Apr.

All the National Universities owned by the Japanese Government became National University
Corporations. and the University of Corporation.

2007

Apr.

The School of Public Health was established. This school offers programs for Master of Public
Health.

2008

May.

The University of Tokyo Faculty of Medicine and the University of Tokyo Hospital celebrated
their 150th anniversary.

2010

Apr.

The School of Health Science and Nursing became the School of Integrated Health Sciences.

2011

Jan.

The Museum of Health and Medicine was established.

3As of Jun. 1, 2011

Graduate School of Medicine

Dean Kohei Moyazono

Molecular Cell Biology
P14

Cell Biology andAnatomyBiochemistry andMolecular Biology

Cell Biology
Structural Biology
Structural Cell Biology
Cellular Neurobiology
Molecular Biology
Cellular Signaling
Physiological Chemistry
and Metabolism

Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Yosuke Takei
Masahide Kikkawa
Yoshimitsu Kanai
Shigeo Okabe
Hiroto Okayama
Shigeki Jinno
Takao Shimizu
Motonao Nakamura
Hiroki Kurihara

Functional Biology
Physiology
P17
Pharmacology

Integrative Physiology

Professor
Associate Professor
Cellular and Molecular Physiology
Professor
Neurophysiology
Professor
Associate Professor
Cellular and Molecular Pharmacology Professor
Molecular Neurobiology
Professor

Yasushi Miyashita
Seiki Konishi
Kensaku Mori
Masanobu Kano
Kazuo Kitamura
Masamitsu Iino
Masayoshi Mishina

Pathology, Immunology and Microbiology
Pathology
P19
Microbiology
Immunology*Collaborative Department

Masashi Fukayama
Hiroshi Uozaki
Associate Professor Shumpei Ishikawa
Professor
Kohei Miyazono
Molecular Pathology
Associate Professor Tetsuro Watabe
Microbiology
Professor
Masanori Hatakeyama
Infection Control and Prevention
Professor
Kyoji Moriya
Professor
Tadatsugu Taniguchi
Immunology
Associate Professor Kenya Honda
Tumor Pathology / Infection Pathology / Molecular Oncology
Professor

Pathology and Diagnostic Pathology Associate Professor

Radiology and Biomedical Engineering
Radiology

Diagnostic Radiology

Biomedical Engineering

Radiotherapy
Nuclear Medicine
System Physiology
Chemical Biology and Molecular Imaging Professor
Biosystem Construction and Control Associate Professor

P21

Professor
Associate Professor
Associate Professor
Associate Professor

Kuni Ohtomo
Satoshi Kunimatsu
Keiichi Nakagawa
Toshimitsu Momose
Yasuteru Urano
Yusuke Abe

Neuroscience
Basic Neuroscience
P23

4Integrative Medical
Neuroscience

Neuropathology
Neurochemistry
Neurobiology
Developmental Neuroscience
Cognitive Neuroscience
Systems Medical Neuroscience
Child Neuropsychiatry

Professor
Associate Professor
Professor

Takeshi Iwatsubo
Haruhiko Bito
Kenzo Hirose

Associate Professor

Katsuyuki Sakai

Associate Professor

Yukiko Kano

Clinical Neuroscience

Neuropsychiatry
Neurology
Neurosurgery

P26

Social Medicine
Occupational,
Environmental andPreventive Medicine
Forensic Medicine, andMedical Informatics andEconomics
Internal Medicine
Medicine I

P28
Medicine II

Clinical Laboratory
Medicine and Pathology

Molecular Preventive Medicine
Public HealthRadiological HealthForensic Medicine
Medical Informatics and Economics

Cardiovascular Medicine
Vascular Biology
Respiratory Medicine
Gastroenterology
Nephrology
Endocrinology
Nutrition and Metabolism
Hematology and Oncology
Allergy and Rheumatology
Infectious Diseases
Stress Science and Psychosomatic
Medicine
Clinical Laboratory Medicine
Transfusion Medicine

Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Kiyoto Kasai
Hidenori Yamasue
Chihiro Kakiuchi
Shoji Tsuji
Shin Kwak
Nobuhito Saito
Kensuke Kawai

Professor
Associate Professor
Professor
Associate Professor

Kouji Matsushima
Sho Ishikawa-Yamawaki
Yasuki Kobayashi
Takahiro Higashi

Professor
Professor

Ken-ichi Yoshida
Kazuhiko Ohe

Professor

Ryozo Nagai

Professor
Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Takahide Nagase
Kazuhiko Koike
Toshiro Fujita
Toshiro Fujita
Takashi Kadowaki
Kohjiro Ueki
Mineo Kurokawa
Kazuhiko Yamamoto
Hiroshi Yotsuyanagi
Akira Akabayashi
Kazuhiro Yoshiuchi
Yutaka Yatomi
Hitoshi Ikeda
Koki Takahashi

Professor
Associate Professor
Associate Professor
Professor
Professor

Yuji Taketani
Tomoyuki Fujii
Tetsu Yano
Shiro Kozuma
Shiro Kozuma

Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Professor

Takashi Igarashi
Kohmei Ida
Takashi Igarashi
Sachiko Kitanaka
Tadashi Iwanaka
Tadashi Iwanaka
Yasuyoshi Ouchi
Masahiro Akishita
Yasuyoshi Ouchi

Reproductive, Developmental and Aging Sciences
Obstetrics andGynecology
P32
Pediatric Sciences

Reproductive Endocrinology
Gynecological Oncology
Perinatal Medicine
Molecular Cellular Reproductive
Medicine
Pediatrics
Developmental Pediatrics

Aging Sciences

Pediatric Surgery
Pediatric Oncology
Geriatrics
Aging Research5Surgical Sciences
Surgery
P35

Thoracic Surgery
Cardiovascular Surgery

Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor

Jun Nakajima
Minoru Ono
Arata Murakami
Yasuyuki Seto
Sachiyo Nomura
Nobuyuki Shimizu
Norihiro Kokudo
Kiyoshi Hasegawa
Yukio Homma
Haruki Kume
Yasuhiko Sugawara

Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Orthopaedic Surgery
Associate Professor
Ophthalmology
Professor
Associate Professor
Associate Professor
Otorhinolaryngology and Head &Professor
Neck Surgery
Associate Professor
Associate Professor
Rehabilitation Medicine
Professor
Anesthesiology
Professor
Emergency and Critical Care Medicine Professor

Joji Kitayama
Tetsuro Miyata
Toshihisa Ogawa
Shinichi Sato
Takafumi Kadono
Isao Koshima
Tsuyoshi Takato
Takafumi Susami
Yoshiyuki Mori
Hiroshi Kawaguchi
Sakae Tanaka
Shiro Amano
Satoshi Kato
Yasuhiro Tamaki
Tatsuya Yamasoba
Takahiro Asakage
Shinichi Iwasaki
Nobuhiko Haga
Yoshitsugu Yamada
Naoki Yahagi

Gastrointestinal Surgery
Hepatobiliary Pancreatic Surgery
UrologySensory and Motor
System Medicine

Vital Care Medicine

Artificial Organ and Transplantation
Division
Surgical Oncology
Associate Professor
Vascular Surgery
Associate Professor
Metabolic Care and Endocrine Surgery Associate Professor
Professor
Dermatology

Plastic and Reconstructive Surgery
Oral and Maxillofacial Surgery

Health Sciences and Nursing
Health Sciences
P42

Preventive andAdministrative Nursing

Clinical Nursing

6

Health Sociology
Mental HealthProfessor
Associate Professor
Epidemiology and Preventive Health Professor

Norito Kawakami
Akihito Shimazu
Yasuo Ohashi

Professor
Associate Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor
Professor
Professor
Professor
Professor
Professor
Professor

Ichiro Kai
Jung Su Lee
Yutaka Matsuyama
Akira Akabayashi
Katsuya Kanda
Katsuya Kanda
Kiyoko Kamibeppu
Sachiyo Murashima
Sachiyo Murashima
Hiromi Sanada
Hiromi Sanada
Sachiyo Murashima
Norito Kawakami
Hiromi Sanada
Hiromi Sanada

Sciences
Social Gerontology
Health Promotion Sciences
Biostatistics
Biomedical Ethics
Advanced Clinical Nursing
Nursing Administration
Family Nursing
Community Health Nursing
Public Health Nursing
Adult Nursing
Palliative Care Nursing
Midwifery and Women's Health
Psychiatric Nursing
Gerontological Nursing
Wound Care Management

International Health
P46

International Social
Medicine
International
Biomedical Sciences

Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Kenji Shibuya
Masamine Jimba
Katsushi Tokunaga
Akihiko Mabuchi
Masashi Mizuguchi
Teruyuki Tanaka
Chiho Watanabe
Masahiro Umezaki
Kiyoshi Kita
Yoh-ichi Watanabe

Professor
Associate Professor
Social and Preventive Epidemiology Professor
Health Economics and Epidemiology Professor
Research
Associate Professor
Health Communication
Professor
Associate Professor
Mental HealthProfessor
Associate Professor

Yasuo Ohashi
Yutaka Matsuyama
Satoshi Sasaki
Hideki Hashimoto
Takashi Fukuda
Takahiro Kiuchi
Hirono Ishikawa
Norito Kawakami
Akihito Shimazu

Global Health Policy
Community and Global Health
Human Genetics
Developmental Medical Sciences
Human Ecology
Biomedical Chemistry

School of Public Health
P49

Epidemiology and
Health Sciences

Behavioral Health
Sciences

Health Services Sciences

Biostatistics

Health Sociology and Health Education
Professor
Social Gerontology
Health Promotion Science
Associate Professor
Biomedical Ethics
Professor
Health Policy
Professor
Healthcare Informatics
Clinical Information Engineering
Forensic Medicine and Medical Law

Associate Professor
Professor
Professor
Professor

Center for Disease Biology and Integrative Medicine
P51

Laboratory of Molecular Biomedicine for Pathogenesis
Laboratory of Structural Physiology
Laboratory of Regenerative Medical Engineering
Laboratory of Clinical Biotechnology
Laboratory of Environmental Health Sciences
Laboratory of Animal Resources
Laboratory of Molecular Radiology
Divisions of Research Resources and Support(Section of Animal Research)(Section of Radiation Biology)(Section of Bioinfomatics)

Ichiro Kai
Jung Su Lee
Akira Akabayashi
Yasuki Kobayashi
Takahiro Higashi
Kazuhiko Ohe
Hiroshi Oyama
Ken-ichi Yoshida

Director Masamitsu Iino
Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Toru Miyazaki
Haruo Kasai
Takashi Ushida
Taichi Ito
Kazunori Kataoka
Nobuhiro Nishiyama
Chiharu Tohyama
Seiichiroh Ohsako
Atsu Aiba
Kazuki Nakao
Kiyoshi Miyagawa

Head
Head
Head
Head

Yasuyuki Seto
Kazuhiko Ohe
Masahide Kikkawa
Kazuhiko Ohe

Institution
P54

Office of International Academic Affairs
Medical Library
Medical Scientist Training Program
Museum of Health and Medicine

7Endowed Department
Pharmacoepidemiology
Professor
Department of Integrated Traditional Medicine (Tsumura)
Associate Professor
Department of Vascular Regeneration (Daiichi Sankyo Co., Ltd.) Associate Professor
Department of Bone & Cartilage Regenerative Medicine
Associate Professor
Department of Cartilage & Bone Regeneration (Fujisoft)
Associate Professor
Department of Clinical Renal Regeneration
Associate Professor
Clinical Molecular Epidemiology (Mitsubishi Tanabe Pharma Corporation) Associate Professor
Immunotherapeutics (Medinet)
Associate Professor
Total Renal Care Medicine
Associate Professor
Integrated Molecular Science on Metabolic Diseases
Associate Professor
Department of Advanced Clinical Science and Therapeutics
Associate Professor
Ischemic Circulatory Physiology, Kaatsu Training
Translational Research for Healthcare and Clinical Science
Department of Joint Disease Research
Health Management and Policy
Computational Diagnostic Radiology and Preventive Medicine
Clinical Motor System Medicine
Healthcare Safety Management (Tokio Marine & Nichido)
Molecular Cardiovascular Metabolism
Department of Healthcare Quality Assessment
Anti-Aging Medicine
Integrated Imaging Informatics
Department of Nutriproteomics
Clinical Epidemiology and Systems
Clinical Trial Data Management
Pharmacology and Pharmacokinetics
Ubiquitous Preventive Medicine
Science for Joint Reconstruction
Therapeutic Strategy for Heart Failure
Molecular Neuroscience on Neurodegeneration
Chronic Kidney Disease
Molecular Structure and Dynamics (JEOL / Zeiss)
Molecular Vascular Endocrinology
Department of Medical Genomics
Continence Medicine
Department of Molecular Psychiatry
Department of Life Support Technology (Molten)
Quality Assessment and Control of Medical Device Sterilization
Department of Youth Mental HealthMolecular Medicinal Sciences on Metabolic Regulation

8

Associate Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor

Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor

Kiyoshi Kubota
Tetsuro Okabe
Hiroyuki Koyama
Taku Saito
Kazuto Hoshi
Keiichi Hishikawa
Takanari Gotoda
Kazuhiro Kakimi
Akira Ishikawa
Kazuo Hara
Junichi Suzuki
Yasunobu Hirata
Toshiaki Nakajima
Hiroyuki Morita
Noriko Yoshimura
Hideo Yasunaga
Naoto Hayashi
Kansei Uno
Toru Akune
Yasushi Kodama
Katsuyuki Ando
Hiroaki Miyata
Satoshi Inoue
Naoki Yoshioka
Kazumi Yagasaki
Tsutomu Yamazaki
Daisuke Koide
Takuhiro Yamaguchi
Akihiro Hisaka
Toru Suzuki
Yoshio Takatori
Toru Moro
Shunei Kyo
Satoshi Gojo
Takashi Nishimura
Atsushi Iwata
Miki Nagase
Nobutaka Hirokawa
Masashi Isshiki
Hiroyuki Mano
CHOI Young Lim
Yasuhiko Igawa
Kazuya Iwamoto
Taketoshi Mori
Yushi Uetera
Tsuyoshi Araki
Hiroaki OkazakiSocial Cooperation Program
Department of Ubiquitous Health Informatics
Department of Lipidomics
Functional Regulation of Adipocytes

Associate Professor
Associate Professor
Associate Professor

Hideo Fujita
Yoshihiro Kita
Hironori Waki

Research Unit
Translational Systems Biology and Medicine Initiative
Associate Professor
Organization of the Center for Supporting Innovative
Professor
Medicine and Execution of Translational Research
Associate Professor
Comprehensive Center of Education and Research for
Associate Professor
Chemical Biology of the Diseases
Associate Professor
Medical System Innovation through Multidisciplinary Integration Associate Professor
Cancer Genomics Project
Associate Professor
Human Resource Development for Multidisciplianary Medical Teams Associate Professor

Faculty of Medicine
School of Medicine

School of
Integrated Health
Sciences

Naoto Kubota
Tomoki Todo
Yasushi Ino
Ichiro Manabe
Hiroshi Kawasaki
Keiji Itaka
Seishi Ogawa
Masato Eto

Dean Kohei Moyazono
Cell Biology and Anatomy / Biochemistry and Molecular Biology / Physiology /Pharmacology / Pathology / Microbiology / Immunology / Radiology /Biomedical Engineering / Basic Neuroscience / Integrative Medical Neuroscience /Clinical Neuroscience / Occupational, Environmental and Preventive Medicine /Medical Principles and Medical Ethics / Forensic Medicine, and Medical
Informatics and Economics / Medicine I / Medicine II / Clinincal Laboratory
Medicine and Pathology / Obstetrics and Gynecology / Pediatric Science /Aging Science / Sugery / Sensory and Motor System Medicine / Vital Care
Medicine
Family Nursing / Community Health Nursing / Fundamental Nursing /Gerontological Nursing / Midwifery and Women's Health /Adult Health and Nursing / Mental Health and Nursing / Health Sociology /Health Administration / Epidemiology and Biostatistics / Human Ecology /Biochemistry and Nutrition / Maternal and Child Health9University Hospital

Director Takashi Kadowaki

Clinical Division
Department ofInternal Medicine

Department ofSurgery

Department ofsensory andMotor System Medicine

General Medicine
Cardiovascular Medicine
Respiratory Medicine
Gastroenterology
Nephrology and Endocrinology
Metabolic Diseases

Professor
Professor
Professor
Professor
Professor
Professor
Associate Professor
Hematology and Oncology
Professor
Allergy and Rheumatology
Professor
Infectious Diseases
Associate Professor
Neurology
Professor
Associate Professor
Geriatric Medicine
Professor
Associate Professor
Psychosomatic Medicine
Professor
Associate Professor
General Surgery
Professor
Stomach and Esophageal Surgery
Professor
Associate Professor
Colon and Rectal Surgery
Associate Professor
Hepatobiliary Pancreatic Surgery
Professor
Associate Professor
Vascular Surgery
Associate Professor
Breast and Endocrine Surgery
Associate Professor
Artificial Organ and Transplantation Professor
Surgery
Associate Professor
Cardiovascular Surgery
Professor
Associate Professor
Thoracic Surgery
Associate Professor
Neurosurgery
Professor
Associate Professor
Anesthesiology and Pain Relief Center Professor
Urology and Andrology
Professor
Associate Professor
Gynecologic Surgery
Associate Professor
Dermatology and Photolaser Medicine Professor
Associate Professor
Ophthalmology and Vision Correction Professor
Associate Professor
Associate Professor
Orthopaedic Surgery and Spinal
Associate Professor
Surgery
Associate Professor
Otorhinolaryngology, and Auditory Professor
and Voice Surgery
Associate Professor
Associate Professor
Rehabilitation Medicine
Professor
Plastic, Reconstructive and Aesthetic Professor

Surgery
Oral-Maxillofacial Surgery,
Dentistry and Orthodontics

Department ofPediatrics, Perinatal and
Women's Medicine

10

Pediatrics
Pediatric Surgery
Obstetrics and Gynecology

Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Professor
Associate Professor

Takahide Nagase
Ryozo Nagai
Takahide Nagase
Kazuhiko Koike
Toshiro Fujita
Takashi Kadowaki
Kojiro Ueki
Mineo Kurokawa
Kazuhiko Yamamoto
Hiroshi Yotsuyanagi
Shoji Tsuji
Shin Kwak
Yasuyoshi Ouchi
Masahiro Akishita
Akira Akabayashi
Kazuhiro Yoshiuchi
Norihiro Kokudo
Yasuyuki Seto
Sachiyo Nomura
Joji Kitayama
Norihiro Kokudo
Kiyoshi Hasegawa
Tetsuro Miyata
Toshihisa Ogawa
Norihiro Kokudo
Yasuhiko Sugawara
Minoru Ono
Arata Murakami
Jun Nakajima
Nobuhito Saito
Kensuke Kawai
Yoshitsugu Yamada
Yukio Honma
Haruki Kume
Tetsu Yano
Shinichi Sato
Takefumi Kadono
Shiro Amano
Yasuhiro Tamaki
Satoshi Kato
Hiroshi Kawaguchi
Sakae Tanaka
Tatsuya Yamasoba
Takahiro Asakage
Shinichi Iwasaki
Nobuhiko Haga
Isao Koshima
Tsuyoshi Takato
Takafumi Susami
Yoshiyuki Mori
Takashi Igarashi
Sachiko Kitanaka
Koumei Ida
Tadashi Iwanaka
Yuji Takatani
Tomoyuki Fujii

Department of
Neuropsychiatry

Neuropsychiatry

Department ofRadiology

Radiology

Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor

Kiyoto Kasai
Hidenori Yamasue
Chihiro Kakiuchi
Kuni Ohtomo
Keiichi Nakagawa
Toshimitsu Momose
Akira Kunimatsu

Central Clinical Facilities
Pharmaceutical Department
Clinical Laboratory
Operation Center
Imaging Center
Emergency Services
Department of Blood Transfusion
Perinatal Center
Rehabilitation Service
Department of Medical Engineering
Central Supply Service
Intensive Care Unit
Pathology
Department of Corneal Transplantation
Department of Cell Therapy and Transplantation Medicine
Department of Endoscopy and Endoscopic Surgery
Department of Hemodialysis and Apheresis
Medical Community Network and Discharge Planning
Infection Control and Prevention Service
Department of Planning, Information and Management
University Hospital Medical Information Network Center
Organ Transplantation Service
Department of Nutrition
Labor Safety and Health Management OfficeChild Psychiatry
Tissue Bank
Epidemiology and Preventive Medicine
Cancer Resource Center
Center for Liaison and Public Relations
Database Center of the National University Hospital
Department of Chemotherapy
Neonatal and Pediatric Intensive Care Unit
Department of Medical Record Management
Critical Care Center
Department of Palliative Medicine
Nursing Department
Administration Office

Professor
Hiroshi Suzuki
Associate Professor Kousei Ito
Director
Yutaka Yatomi
Vice Director
Hitoshi Ikeda
Professor
Hiroshi Yasuhara
Associate Professor Kazuhiko Fukatsu
Professor and Director Kuni Ohtomo
Associate Professor Masaaki Akabane
Professor
Naoki Yahagi
Professor
Koki Takahashi
Professor
Shiro Kozuma
Professor
Nobuhiko Haga
Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor
Associate Professor

Kazuhiko Fukatsu
Naoki Yahagi
Masashi Fukayama
Hiroshi Uozaki
Satoru Yamagami
Mineo Kurokawa
Mitsuhiro Fujishiro
Toshiro Fujita
Eisei Noiri
Yasuyoshi Ouchi
Kyoji Moriya
Kazuhiko Ohe
Soichi Koike
Takahiro Kiuchi
Norihiro Kokudo
Yasuhiko Sugawara

Associate Professor
Associate Professor

Shin Onishi
Yukiko Kano

Professor

Tsutomu Yamazaki

Professor

Kazuhiko Ohe

Professor
Associate Professor
Professor
Associate Professor
Associate Professor

Norihiro Kokudo
Arata Murakami
Yasuyoshi Ouchi
Susumu Nakajima
Keichi Nakagawa

11

Clinical Research Division
Clinical Research Support Center
22nd Century Medical and Research Center
Department of Tissue Engineering
Cooperative Unit of Medicine and Engineering Research
Translational Research Center
Center for Genome Medicine

Professor
Professor
Professor
Associate Professor
Professor
Professor

Nobuto Saito
Tsuyoshi Takato
Tsuyoshi Takato
Tetsuro Miyata
Ryozo Nagai
Shoji Tsuji

Organization of Clinical Management Support
Department of Personnel Administration and Human Resource Management /Department of Performance Monitoring, Risk Management, and Staff Development /Department of Hospital Planning and Management /Department of Education and Research Support
Associate Professor Nobuyuki Shimizu
Associate Professor Shin Onishi

Organization of Clinical Management
Inpatient Services Administration / Outpatient Services Administration /Central Clinical Services Administration

CenterP56

12

The International Research Center for Medical Education

Director
Professor

Kazuhiko Yamamoto
Kiyoshi Kitamura

Faculty of Medicine
Graduate School of
Medicine
The University of Tokyo

Graduate School of Medicine

Molecular Cell Biology.............................................. 14
Functional Biology..................................................... 17
Pathology, Immunology and Microbiology.................. 19
Radiology and Biomedical Engineering....................... 21
Neuroscience ..........................................................23
Social Medicine........................................................26
Internal Medicine . ...................................................28
Reproductive, Developmental and Aging Sciences . ....32
Surgical Sciences .....................................................35
Health Sciences and Nursing ....................................42
International Health .................................................46
School of Public Health ............................................49
Center for Disease Biology and Integrative Medicine... 51
Institution

Office of International Academic Affairs
Medical library
Medical Scientist Trainning Program
Museum of Health and Medicine................................54
CenterThe International Research Center for Medical Education
and Research.............................................................56

13

A
G
C
T
Molecular Cell Biology

Cell Biology and Anatomy

http://cb.m.u-tokyo.ac.jp/

Cells transport various kinds of proteins, lipids and mRNAs after synthesis
to their specific destinations such as several types of membranousorganelles, protein complexes and the mRNA complex. Thus, intracellulartransport is fundamental to cellular functions, survival and morphogenesis.
Our laboratory is studying the mechanisms of intracellular transport andcellular morphogenesis, especially focusing on molecular motors, Kinesin
superfamily proteins (KIFs) and microtubule associated proteins (MAPs)
using molecular cell biology, biophysics, structural biology, and molecular
genetics
Molecular cell biological study of KIFs
Studies of the mechanism for recognition of and binding to cargoes by KIFs
and the regulation of this mechanism● Studies of the mechanisms of differential directional transports and sorting● Studies of the dynamics and mechanism of motility of KIFs using molecularbiophysics and structural biology● Molecular genetics of KIFs
● Studies of KIFs and related diseases● Molecular cell biology and molecular genetics of MAPs●●

Schematic representation of intracellular transport
performed by Kinesin superfamily motor proteins, KIFs.
(Reproduced from the cover of Nature Review of
Molecular Cell Biology 10, 2009)http://structure.m.u-tokyo.ac.jp/

Structural Biology
Kikkawa lab is interested in flagella/cilia, which works as an actuator as well
as a sensor of cells. We are studying the mechanism of formation andfunction of flagella/cilia using cryo-electron microscopy, optical microscopy,
and genetics. We are also developing new technologies to analyze images
taken by microscopes.
Our focuses are:● Molecular formation of flagella and axonemal dyneins.
● Mechanism of force generation by dyneins.
● Structures of microtubule-associated proteins● Development of new image analysis methods for cryo-electron microscopeThree dimensional reconstruction of the outer dynein
arm-microtubule complex from wild type. A: rigor state
and B: relaxed state.

14

Structural Cell Biology

http://cb.m.u-tokyo.ac.jp/

Our research aims to elucidate the cellular architecture, especially focusing on
the cytoskeleton by combining molecular cell biology, molecular genetics andstructural biology.
Structure of the cytoskeleton and the related proteins
Dynamics of the cytoskeleton and the related proteins● Function of the cytoskeleton and the related proteins●●

The neuronal cytoskeleton（From Nature Milestones 2008）

Cellular Neurobiology
The Laboratory of Cellular Neurobiology is interested in understanding themolecular mechanisms regulating synapse formation and maintenance,
which are essential in proper function of neural circuits in the brain. The
laboratory is using optical imaging of synaptic molecules in live neurons, in
combination with molecular biological approaches to modify neuronal
functions.
Molecular architecture of the postsynaptic density
Molecular mechanisms of activity-dependent synapse remodeling● Regulation of synapse functions by glial cells● Regulation of synapse formation and maintenance in vivo●●

Quantitative fluorescence imaging of cultured
hippocampal neurons (green: postsynaptic protein andcalibrated fluorescent microspheres, red: presynaptic
protein, blue: microtubule-associated protein)

Molecular Biology

http://www.cellcycle.m.u-tokyo.ac.jp

We have been studying the molecular mechanism
enabling anchorage-independent S phase onset that is
the key for malignant transformation.
Understanding the anchorage signal cascades that
control cell cycling● Understanding the mechanism by which anchorage
signals control the G1-S transition●

15

Cellular Signaling

http://biochem2.umin.jp/index_j.html

Our laboratory specializes in biochemistry, molecular and cellular biology,
and genetic engineering to elucidate the roles of lipid mediators in vivo. We
further study the molecular mechanism and biological significance ofdiversity and asymmetry of cellular membrane lipids. In collaboration with
the Department of Lipidomics, we analyze stimulus induced dynamic changes
in the lipid composition of the cellular membrane.
Discovery and structural determination of novel lipid mediators
Cloning, functional characterization and K/O studies of enzymes involved in
the metabolism of lipid mediators and receptors for lipid mediators● Structure, function and dynamics of GPCR
● Lipidomics and enzyme characterization of membrance organization●●

Production of lipid mediators during Lands' Cycle and activation of GPCRs(Shimizu,T., Ann. Rev. Pharmacol. Toxicol. 49, 123-150, 2009)

Physiological Chemistry and Metabolism

http://bio.m.u-tokyo.ac.jp/

We are investigating signaling mechanisms underlying cell fate
determination, morphogenesis and organogenesis in embryonicdevelopment.
Molecular mechanisms of neural crest fate determination and craniofacial
morphogenesis● Molecular mechanisms of cardiovascular development● Epigenetic control of embryonic development● Roles of microRNA in embryonic development●

Transformation of the upper jaw into a lower jaw inendothelin-1 knock-in (misexpressing) mouse (upper).
The lower is the wild-type control.

16

Functional Biology

http://www.physiol.m.u-tokyo.ac.jp/
indexe/indexe.html

Integrative Physiology
Our laboratory specializes in the neuroscience research on cognitive functionsin the primate. We investigate interactions among many neurons in the
cerebral cortex, which create human cognitive abilities such as memory andits cognitive control. These studies have been done through integrative efforts
using electrophysiological, molecular biological and neuroimaging
approaches.
Neural circuits of memory neurons in the temporal cortex
Roles of the top-down signal from the prefrontal cortex● Functional architecture of the prefrontal cortex● Molecular biological basis of declarative memory in the primate● Development of optogenetics and viral gene-delivery methods inthe primate● High-field MRI for humans and monkeys●●

Cellular and Molecular Physiology

Brain activation in cognitive tasks (left) and gene
expression (BDNF) in cortical neurons

http://morilab.m.u-tokyo.ac.jp/eindex.html

We aim at a better understanding of neuronal mechanisms thattranslate sensory information of the external world into
motivational and emotional responses. We are currently analyzing
the central nervous system for olfaction, a sensory modality thathas a strong influence on human emotion. Another major focus ist o u n d e r s t a n d c e l l u l a r a n d m o l e c u l a r m e ch a n i s m s f o r
reorganization of neuronal circuits and memory consolidation in
the central olfactory system.
Functional analysis of the neuronal circuit in the central olfactory
nervous system (olfactory bulb and olfactory cortex)● Neurogenesis and neuron-elimination in the adult brain● Cellular and molecular mechanisms for the reorganization ofneuronal circuits and memory consolidation in the central olfactory
system.
●Neuronal circuits and 'odor maps' in the olfactory nervous system

17Neurophysiology

http://plaza.umin.ac.jp/˜neurophy/

Our laboratory studies the function of the synapse, a key
structure for brain functions, and its changes related topostnatal development, learning, and memory. We make realtime monitoring of neuronal acti vities, using various
methodologies including electrophysiology, molecular biology,
and optical imaging of functional molecules.
Postnatal development of synaptic function and organization in the
cerebellum● Retrograde synaptic modulation mediated by endogenous
cannabinoids● Synaptic integration in intact animals● Synaptic plasticity and motor learning in the cerebellum●

Cellular and Molecular Pharmacology

Molecular mechanisms of endocannabinoid-mediated retrograde
modulation of synaptic transmission

http://calcium.cmp.m.u-tokyo.ac.jp/

We are studying the basic principles of Ca 2+ signaling, thefundamental signal transduction mechanism of life. Based onsuch studies, we are searching for new functions of Ca 2+
signaling in the central nervous system, and are aiming atshedding new light on brain functions using innovative imaging
methods.
Elucidation of basic principles of Ca2+ signaling
Search for new functions of Ca2+ signaling in the brain● Functional analyses of neurons and glial cells using imaging
methods of signaling molecules●●

Outline of our research on Ca2+ signaling

Molecular Neurobiology

http://www.pharmacol2.m.u-tokyo.ac.jp/

We have been investigating the molecular basis of higher brain
functions by focusing on the glutamate receptor and memory. Previous
studies have led to the hypothesis that there is a common principle
between memory signaling and synapse formation. The combinationof conditional gene targeting in mice and molecular genetics in zebra
fish will facilitate our understanding of the mechanism of higher brain
function at the molecular, cellular and neural network levels.
Regulation of brain functions by glutamate receptors in specific brain
regions◦ Identification of neural networks for learning and memory◦ Regulation of learning and memory◦ Roles of glutamate receptors in decision-making● Signaling from glutamate receptors to memory● Molecular mechanisms of synapse formation and remodeling◦ Molecular mechanism of synapse formation during development◦ Molecular mechanism of synapse remodeling in the adult brain●

18

From synaptic molecules to brain function and dysfunction

Pathology, Immunology and Microbiology

Pathology and Diagnostic Pathology

http://pathol.umin.ac.jp/index_e.htm

We investigate the pathogenesis and pathobiology of disease,especially the neoplastic diseases, by means of morphology. Our
goal is to discover new entities and to clarify unknown
pathogenesis of diseases through the interaction with clinicalmedicine.
Chronic inflammation and neoplasm◦ Epstein-Barr virus associated gastric carcinoma◦ Epigenetics of carcinoma◦ Carcinoma-stromal interaction◦ Lung adenocarcinoma and its scar formation◦ Lung fibrosis and adenocarcinoma● Application of molecular pathology to pathological diagnosis◦ Discovery of cancer therapy target by DNA chip technology◦ Establishment of objective criteria for cancer grading◦ Streamlining and acceleration of pathological diagnostic processes●

Molecular Pathology

Investigation of the development of EB virus-associated gastric carcinoma

http://beta-lab.umin.ac.jp/index.htm

Our research is focused on the molecular mechanisms ofcarcinogenesis. We study the signaling mechanisms of the
TGF-b family, including TGF-b and bone morphogenetic
proteins (BMPs), and elucidate how they regulate
progression of cancers. We also investigate the mechanismsof differentiation of murine embryonic stem cells (ESCs)
into various cells, including vascular and lymphatic
endothelial cells. Based on these findings, we will develop
new strategies for the treatment of vascular and lymphatic
diseases and cancer.
Molecular mechanisms of growth regulation by TGF- b
Roles of TGF- b in epithelial-to-mesenchymal transition
Signaling by TGF-β (left) and TGF-β-mediated EMT of mammry epithelial cells (right)● Effects of TGF- b family cytokines on cancer-initiating cells● Roles of TGF- b family cytokines in vascular and lymphatic diseases● Differentiation of vascular and lymphatic endothelial cells and mechanisms of diseases●●

19Microbiology

http://microbiology.m.u-tokyo.ac.jp/

Our major objective is to elucidate molecular mechanisms
underlying development of gastric carcinoma triggered by
infection with Helicobacter pylori. Based on the results obtained
from these studies, we are also developing new strategies forprevention and treatment of infection/inflammation-associatedcancers, which account for ~ 50% of entire human malignancies.
Structural biological analysis of H. pylori oncoprotein CagA
Intracellular signaling pathways targeted by CagA
● Mouse genetic studies on gastric carcinogenesis● Host genetic factors determining gastric cancer susceptibility● Molecular mechanisms linking inflammation and cancer●●

H. pylori - gastric epithelial cell interaction

Infection Control and Prevention
We are engaged in education of medical staff as wellas in daily clinicalactivities on the prevention of healthcare-associated infection (HAI). Research
activities on the pathogenesis of infection with hepatitis viruses and HIV, in
particular, on the mechanism of hepatocarcinogenesis in HCV infection are
also our mission.
Development of preemptive strategies for the control of healthcare-associatedinfection● Development of new methods in infection control and treatment of viral hepatitis● Molecular pathogenesis of hepatocellular carcinoma in HCV infection● Pathogenesis of progression of HIV infection● Molecular pathogenesis of the mitochondrial disturbances in viral infections● Molecular pathogenesis of hepatitis B viral infection● Host defences to microorganisms● Molecular analysis of innate immunity in microorganism infection● New detection method and pathogenesis of opportunistic cytomegaloviral infection● Mechanism of multi-drug resistant microorganisms●

Immunology
Since its initial identification of the genes for interferon (IFN)-b andinterleukin (IL)-2, our laboratory has continued to elucidate thesignal transduction and transcriptional regulatory networks
involved in immunity and oncogenesis.
The signaling and transcriptional networks that operate in theregulation of and by IFN-a/b during innate immune responses,● The role and regulation of the interferon regulatory factor (IRF)
transcription factor family in innate and adaptive immune responses,● The regulation of dendritic cell maturation/activation in the link
between innate and adaptive immunities,● The molecular mechanisms of protective and pathological immune
responses mediated by nucleic acid sensor proteins,● The regulation of oncogenesis by IRFs,● The regulation of mucosal immune responses.
●

20

Infection control team rounds

http://www.immunol.m.u-tokyo.ac.jp/english

Radiology and Biomedical Engineering

Radiology

http://www.ut-radiology.umin.jp/

We have been performing a variety of clinically oriented research programs inbiomedical imaging, voxel-based or ROI-based analysis, information analysis
and radiotherapy, such as computer-assisted diagnosis (CAD), PET-based
diagnosis, and intensity modulated radiotherapy (IMRT).
Diagnostic Radiology◦ Multi-row detector (up to 16 rows) helical computed tomography◦ MR imaging, MR digital subtraction angiography, perfusion imaging, and		 diffusion tensor imaging/tractography● Radiation Oncology◦ Physical engineering aspect of radiotherapy◦ Stereotactic irradiation by gamma knife and synergy system and IMRT
◦ Clinical and biological studies for reduction of radiation-induced damage● Nuclear Medicine
Representative images analyzed with computerassisted technology◦ Functional imaging by radioisotope-labeled tracer technology◦ Evaluation of blood flow and metabolism by emission tomography (PET and SPECT)●

Chemical Biology and Molecular Imaging

http://cbmi.m.u-tokyo.ac.jp/

Our research field is so-called chemical biology. One of our main
research interests is to develop novel small molecule-based photofunctional tools for biological and medical research, including
fluorescence probes for detecting various events in living cells andanimals. Recently, we have succeeded to develop fluorescenceprobes for in vivo tumor detection, and they are now applied to realresected human samples by collaborating with many surgeons.
Establishment of rational design strategies for various photofunctional small molecule-based probes● Development of novel fluorescence probes, photosensitizing probes
and caged compounds, and their application to various living
biological samples● In vivo detection and therapy of tumors in model mice and real humansamples by using rationally designed novel fluorescence andphotosensitizing probes●

21Biosystem Construction and Control

http://www.bme.gr.jp/bme_E/

Our research fields include medical engineering high-technologies
represented by artificial organs. Especially the research of artificial
heart has gotten excellent results such as the world longest survival
record in animal replaced with a total artificial heart. We are
performing the researches from the basic to the application.
Implantable total artificial heart
Implantable ventricular assist device● Polymer artificial valve● Next generation artificial lung
● Tissue engineered artificial organs● Blood compatible material● Implantable pressure sensor● Implantable angiogenesis observation probe●●

22

Implantable total artificial heart (Undulation pump total
artificial heart) and artificial heart animal (goat)Neuroscience

Neuropathology
Elucidate the pathomechanism of neuronal degeneration and death in major
neurodegenerative disorders (e.g., Alzheimer disease, Parkinson disease), anddevelop novel strategies for disease-modifying therapies.
Structural and functional analysis of g-secretase
Molecular analysis of the mode of action of g-secretase inhibitors● Mechanism of Ab production, aggregation and clearance● Pathological function of b-amyloid binding proteins (e.g., CLAC)● Mechanism of aggregation and neurotoxicity of a-synuclein● Pathological function of familial Parkinson disease gene LRRK2● Strategies for development and validation of disease modifying therapies for
Alzheimer disease (J-ADNI Clinical Study)●●

Phosphorylated α-synuclein deposited in Lewy
bodies of Parkinson's disease and Lewy body disease

Neurochemistry

http://www.neurochem.m.u-tokyo.ac.jp/
Homepage.html

Our brain is able to recognize and memorize external and internal events asthey occur. A functional neural network further stands out by its capacity to
extract patterns and rules, and to associate them with abstract meaning andaffective valence. What are the local and global spectra of the molecularsignaling events in neurons that underlie such complex information
processing at the systems level? Are these events, in turn, converted into
more profound modifications of the synaptic wiring mechanisms? To addressthese issues, we are currently investigating the chemistry and physiology ofvarious neuronal protein complexes near and at synapses.
Molecular investigation (including identification, characterization and real-timevisualization) of signaling molecules involved in calcium-dependent synaptic
modification, especially during signaling from synapse-to-nucleus, and back from
nucleus-to-synapses● Understanding molecular mechanisms controlling cytoskeletal dynamics andremodeling on both sides of the synapses, in the dendritic spines and in axon
terminals●

Real-time measurement of biochemical events
triggered by glutamate uncaging at hippocampal
spines (A); Visualization of actin cytoskeleton in
cerebellar Purkinje cell dendrites (B)23Neurobiology

http://www.neurobiol.m.u-tokyo.ac.jp/

The goal of our research is to elucidate regulation
mechanisms of various cell functions. Toward this goal,
we have been developing novel technologies including
live cell imaging and RNAi technologies.
Development of novel strategy for generating
fluorescent probes for live cell imaging
We develop a high-throughput screening system forconstructing high performance fluorescent probes forlive cell imaging.
● Study of synapse physiology by glutamate imaging
techniqueTo clarify the dynamics of exocytosis in excitatory synapses, we have tried to quantitatively analyze released
glutamate at individual synapses by using our original optical glutamate probe.
● Novel technology for construction of genome-wide RNAi library
We are currently constructing a high performance genome-wide RNAi library based on our EPRIL technology.
●

Cognitive Neuroscience

http://square.umin.ac.jp/dcntky/English/Etop.html

We are trying to understand the neural mechanisms of human cognition
using functional MRI, EEG and TMS.
Working memory and cognitive control
Attention, perception and consciousness● Mind-reading and prediction of behavior●●

Child Neuropsychiatry
Main diseases of our current research are autism spectrum
disorders (ASD), ADHD, Tourette syndrome and childhood
Obsessive-compulsive disorder (OCD). From the viewpoint ofdevelopment of brain and mind, we are trying to investigate
pathogenesis of these diseases by integrating
phenomenological, neuropsychological, brain-imaging andgenetic studies. We are also applying this integrative approach
to treatment research for patients with these diseases.

Behavior phenotype, neuropsychological and genetic study ofTourette syndrome and childhood OCD● Brain-imaging study of ASD, ADHD and Tourette syndrome by
structural-MRI, functional-MRI and near-infrared spectroscopy● Genomic and epigenomic analysis of ASD● Development of predictor of pharmacotherapy and parent training for ADHD
● Effectiveness study of early intervention for autistic preschoolers and group cognitive behavior therapy for adults with ASD●

24

Neuropsychiatry

http://www.h.u-tokyo.ac.jp/patient/depts/n_md.html

Our department mainly investigates schizophrenia and pervasive
developmental disorders not only by biological approaches which
integrate neuroimaging, genetic and animal studies, but also by
psycho-social approaches. We also promote the systematic clinicalresearch training programs and the cooperation with the basic
neuroscience research.
Integrated Neuroimaging studies in Schizophrenia Targeting Earlyintervention and Prevention
http://plaza.umin.ac.jp/arms-ut/● Todai Twin Project with Integrative Neuroimaging
http://npsy.umin.jp/study/exam.html● Multimodal neuroimaging studies of pervasive developmental disorders● Clinical trials to establish the medical equipment as a clinical test useful forthe pharmacological treatment of mental disorders●

Neurology

Multi-modality neuroimaging in neuropsychiatry using a combination of high-resolution MRI, EEG, MEG, NIRS, and PET

http://square.umin.ac.jp/neurotky/

Our Department is promoting research programs to elucidate thepathophysiological mechanisms of neurological diseases
including neurodegenerative diseases, immune-mediateddiseases and neuromuscular diseases, and to establish
therapeutic approaches for these diseases. We are also providing
excellent programs to train neurologists.
Molecular Genetics (identification of disease genes anddevelopment of therapeutic approaches)● Molecular pathopysiology of neurological diseases (RNA editing,and protein structures)● Immune-mediated diseases (autoantibodies)● Neuropysiology and cognitive neuroscience (magnetic stimulation,
NIRS, MEG, PET, and fMRI)● Neuropathology of neuromuscular diseases (pathological studies on biopsy and autopsy materials)● Multicenter-based clinical research● Development of new therapeutics●

Neurosurgery

http://www.h.u-tokyo.ac.jp/neurosurg/

The 21st century has been designated as "The Century of theBrain". To lead Japanese Surgical Neuroscience, we havedevoted our activities to the following: advanced Clinical
Neurosurgery, Neuroscience Research and Graduate andPostgraduate education.
Skull base surgery in managing benign or malignant skull basetumors and cerebrovascular disorders● Functional neurosurgery including epilepsy surgery● Development of new therapeutic strategies for malignat brain
tumors● Cinical study on gamma-knife surgery● Application of brain functional imaging for neurosurgery● Application of VR technology for surgical simulation● Experiment on cerebral ischemia● Development of new stenting device for endovascular surgery●

Simulation images using 3D-fusion images and tractography.

25

Social Medicine

Molecular Preventive Medicine
The immune system is maintained by continuous migrationof immune cells between lymphoid organs and peripheral
tissues. Immune cells change their function during thismigration and interact with tissue cells at the periphery. In
the context of disease, immune cells induce functionalchanges, destruction, and remodeling of affected tissues.
We aim to clearify how immune cell migration regulates
immune function, which may lead to the development ofnovel therapeutic and preventive strategies toward various
diseases.

http://www.prevent.m.u-tokyo.ac.jp/㻮㼍㼟㼕㼏㻌㼞㼑㼟㼑㼞㼏㼔
GVHD

㻯㼘㼕㼚㼕㼏㼍㼘㻌㼍㼜㼜㼘㼕㼏㼍㼠㼕㼛㼚㻵㼙㼙㼡㼚㼛㼘㼛㼓㼕㼏㼍㼘㼙㼑㼙㼛㼞㼥
㻵㼚㼐㼕㼢㼕㼐㼡㼍㼘㻰㼞㼡㼓㻌㼐㼑㼢㼑㼘㼛㼜㼙㼑㼚㼠㻻㼞㼓㼍㼚㼟
㻯㼑㼘㼘㻹㼛㼘㼑㼏㼡㼘㼑

㻵㼚㼒㼘㼍㼙㼙㼍㼠㼕㼛㼚㻳㼑㼚㼑㼑㼤㼜㼞㼑㼟㼟㼕㼛㼚㼍㼚㼍㼘㼥㼟㼕㼟㻌㻯㼔㼑㼙㼛㼗㼕㼚㼑㻯㼔㼑㼙㼛㼗㼕㼚㼑㻌㻌㻌㼟㼕㼓㼚㼍㼘㼕㼚㼓㻾㼑㼓㼑㼚㼑㼞㼍㼠㼕㼛㼚㻯㼑㼘㼘㼡㼘㼍㼞
㼠㼞㼍㼒㼒㼕㼏㼗㼕㼚㼓㻯㼔㼑㼙㼛㼗㼕㼚㼑㻌㻛㻌㻯㼔㼑㼙㼛㼗㼕㼚㼑㻌㼞㼑㼏㼑㼜㼠㼛㼞㻭㼚㼠㼕㼎㼛㼐㼥
䊻㻌㻭㼚㼠㼕㻌㼕㼚㼒㼘㼍㼙㼙㼍㼠㼛㼞㼥㻘㻌㻯㼍㼚㼏㼑㼞㻌㼠㼔㼑㼞㼍㼜㼥㻘㻌㻌 㼕㼙㼙㼡㼚㼛㻙㼙㼛㼐㼡㼘㼍㼠㼛㼞㼥㼂㼍㼏㼏㼕㼚㼑㻌㼐㼑㼢㼑㼘㼛㼜㼙㼑㼚㼠䊻㻌㻴㻵㼂㻌㻘㻌㻿㻭㻾㻿㻙㻯㼛㼂㻌㼑㼠㼏㻚㻯㼛㼚㼠㼞㼕㼎㼡㼠㼕㼛㼚㻌㼠㼛㻌㼟㼛㼏㼕㼑㼠㼥

Molecular and cellular basis of tissue fibrosis during chronic inflammation
Pathophysiological regulation of the immune system by chemokines andthe implication of this in GVHD, tumor development, infectious diseases,
and autoimmunity● Development of vaccines against cancers and infectious diseases● Gene expression analysis of hematopoietic and other tissue cells by nextgeneration sequencing●●

Public Health

http://publichealth.m.u-tokyo.ac.jp/

Public health is the science and art of preventing disease,prolonging life, and promoting health and quality of life (QOL)
through organized community effort. Through studies invarious fields and laboratories, our department aims toadvance research, support policy development, and promote
education toward these ends.
Efficiency and equity issues of health systems
Health manpower policy● Occupational and environmental health● Evaluation of preventive services● Health services research●●Physician distribution by municipality in Japan

26

Forensic Medicine

http://plaza.umin.ac.jp/˜forensic/

We conduct autopsies and examinations related to unnatural
deaths and therapeutic deaths. We also perform the following
studies.
Development of new animal model of sleep apnea syndrome, andthe elucidation of the pathogenesis of heart failure and pulmonary
hypertension● Study on the mechanism underlying sudden cardiac deaths andmyocardial lesions related to myocardial infarction andamphetamine-class drug poisoning● Study on the Takotsubo cardiomyopathy-like pathology in restrained
rats● Study on the mechanism underlying propagation of brain contusion● Study on the information disclosure, bereavement service, andresearch use of retained organs in death investigation system● Development of new methods for examinations of drug, histologicaland DNA analyses in autopsy cases.
●

Medical Informatics and Economics

Forensic autopsy room

http://www.m.u-tokyo.ac.jp/medinfo/index_e.html

The role of research and education of this department is provided as
the department of the graduate school, and the role of practicalmanagement is conducted as the Department of Planning,
Information and Management in the University of Tokyo Hospital. Allteaching staffs are in charge of both the two roles and thedepartment of health informatics of school of public health. The
research and postgraduate education programs cover basic medical
informatics, advance applications of information technology forclinical practice, technology assessment and standardization ofhealthcare information.
Development and application of clinical ontology
Research for sharing healthcare data among medical institutions
and hospitals, and the application for clinical epidemiology● Extraction of medical knowledge from electronic medical record
database using natural language processing
Development of clinical ontology● Development of knowledge-driven real time alerting system inclinical practice● Evaluation study of hospital management and analysis of medical resource placement●●

27

Internal Medicine

Cardiovascular Medicine

http://plaza.umin.ac.jp/~utok-card/

We are investigating the pathogenesis, pathophysiology, diagnostic
methods, and novel therapeutic measures for various cardiovasculardiseases (ischemic heart disease, heart failure, cardiomyopathy, arrhythmias,
atherosclerosis, hypertension, etc.) using a variety of research tools (frommolecular biology to epidemiology, bioinformatics).
Interplay between organs, cells, and molecules in chronic inflammation
Transcriptional regulation of various genes involved in cardiovasculardevelopment and pathogenesis● Cardiac hypertrophy and heart failure: analyses of pathogenic mechanisms
and development of novel therapies (gene therapy, etc.)● Differentiation of smooth muscle cells (atherosclerosis and restenosis after
vascular interventions)● Endothelial dysfunction in various diseases● Genetic polymorphisms and risk factors in cardiovascular disease● Optimization of individual treatment using the Computer Heart Simulator● Development of new integrated databases for clinical information and research● Investigation of disease pathophysiology and development of novel therapies (severe heart failure, cardiac transplantation,
Marfan`s syndrome, pulmonary hypertension, congenital heart disease, cardiac rehabilitation, etc.)● Imaging techniques (echocardiography, MRI, CT, RI) in cardiovascular diseases●●

Respiratory Medicine

http://kokyuki.umin.jp/

Based on the fact that a number of patients with respiratory diseases including
lung cancer and COPD is tremendously increasing, fruitful results of respiratory
research are more and more expected in the 21st century. In this era, we areconducting basic and clinical researches for wide variety of respiratory
disorders including lung cancer, asthma and COPD. Especially, we have been
intensively studying the molecular mechanisms underlying the pathogenesis oflung disorders. Our research goal is to develop novel therapeutic tools tomanage these pulmonary diseases.
Clinical studies of lung cancer, COPD, bronchial asthma and pulmonary fibrosis
Epidemiological studies of diffuse panbronchiolitis (DPB) and interstitial lung disease● Molecular mechanisms underlying the pathogenesis of acute lung injury or ARDS
Murine model of pulmonary fibrosis● Molecular mechanisms underlying the pathogenesis of pulmonary fibrosis (as shown in Figure)● Analysis of disease models using genetically-engineered mice
● Effects of air pollutants such as diesel exhausts on airway hyperresponsiveness Roles of chemokines/cytokines and eicosanoids on airway
epithelial cells, smooth muscle cells and eosinophils.
● DNA methylation and lung cancer● Establishment of conditional vectors for hairpin siRNA knockdowns● Establishment of CpG island searcher●●

28

Gastroenterology

http://www.h.u-tokyo.ac.jp/gastro/

Our Department of Gastroenterology is one of the top institutions in the world in
the treatment of hepatocellular carcinoma by unique ablation(RFA) andgastrointestinal/pancreatobiliary cancer/stone by endoscopic
manipulation(ESD&ERCP). The goal of our department is to accurately diagnose
and give the best available treatment to these patients, and to this end, we are
performing a wide variety of basic as well as clinical research.
Development of better therapeutic strategy for hepatitis B and C
Elucidation of hepatocaricinogenesis mechanism in viral hepatitis● Development of a better therapeutic modality for hepatocellular carcinoma& metastatic liver tumor● Elucidation of gastric injury mechanisms by Helicobacter pylori● Clarification of colon disease, especially right-sided colon carcinogenesis● Development of therapeutic strategy for advanced pancreatobiliary cancer● Development of a better endoscopic therapeutic modality for pancreatobiliary cancer/stone● Development of better diagnostic & therapeutic strategy for chronic pancreatitis● Development of an endoscopic en bloc resection method for early gastric, esophageal and colonic cancer● Elucidation of the mechanisms of metabolism-associated liver diseases● Development of better diagnostic & therapeutic strategy for small intestinal diseases●●

Nephrology / Endocrinology

http://plaza.umin.ac.jp/˜kid-endo/top.html

We are investigating the pathophysiology of renal and endocrine disorders
for the development of innovative diagnostic and therapeutic tools.
Hypertension is our special interest because not only it is a serious medical
problem which impairs many vital organs and the QOL of our patients, butalso we have the great advantage of organizing the strategic researchaproach since hypertension is closely related to both nephrology andendocrinology.
Renal physiology and morphology
Pathophysiology of immune-mediated renal injury● Analysis of pathophysiology and prognistic factors of chronic renal failure● Endothelial injury and vascular biology in kidney disease● Role of nitric oxide and oxidative stress in renal disease and hypertension● Clinical and basic investigation of bone and mineral disorders● Mechanism of action of nuclear hormone receptors● Pathophysiology of hypertension and roles of adrenomedullin● G protein signaling in health and disease● Epigenetics and hypertension●●

Nutrition and Metabolism
We are investigating to reveal the molecular mechanisms underlying thedevelopment of metabolic diseases (diabetes mellitus, lipid metabolic
disorders, obesity, metabolic syndrome and atherosclerosis) using
interdisciplinary approaches and state-of-the-art technology including
genetically engineered model animals, DNA chip, epigenetics, RNAtechnology, human genetics, clinical epidemiology and bioinfomatics. Our
major goal is to develop mechanism-based fundamental treatment andprevention strategies for the metabolic diseases.
Molecular mechanism of insulin resistance linked to obesity focusing on adipokines
Transcriptional regulation of insulin resistance and obesity by nuclear receptors and cofactors● Molecular mechanism of insulin signal transduction● Molecular mechanism of insulin secretory defect in type 2 diabetes● Genetic susceptibility and risk factors of type 2 diabetes● Development of accurate diagnostic algorithm for type 2 diabetes● Molecular mechanism of adipogenesis and obesity● Transcriptional regulation of lipid metabolism● Molecular mechanism of atherosclerosis● Mouse genetic models of diabetes, lipid metabolism disorder and atherosclerosis●●

29

Hematology and Oncology

http://www.h.u-tokyo.ac.jp/hematology/

We are investigating the pathogenesis, diagnostic
methods, and novel therapeutics of hematologicaldisorders by making comprehensive use of researchtechnologies in molecular biology, developmental
biology, and immunology. Studies about transcriptional
regulation and signal transduction in hematopoiesis andanalyses of regulation of hematopoietic stem cells are
performed. We are also performing basic and clinicalstudies based on genomics, regenerative medicine, andtransplantation medicine, which aim at application totherapeutic strategies.
Self renewal and differentiation of hematopoietic stem cells
Genome-wide analyses of hematological malignancies● Identification of molecular pathogenesis of leukemia● Analyses of the immune system by developmental biology● Regenerative medicine of hematopoietic cells using human ES and iPS cells●●

Allergy and Rheumatology
Allergy and rheumatic diseases are immune mediated disorders. We areinvestigating the fine mechanisms of such disorders. One of our final
purposes is to establish novel therapies which control pathologicalimmune disorders but do not suppress other physiologically important
immune functions. We are combining recent findings in basic immunology
and our own viewpoints base on our clinical experience.
Clonal analyses of T cell receptor (TCR) , in vitro reconstitution of the TCR
function using such information and antigen specific immunotherapy● Mechanisms of oral tolerance and application to therapeutic strategies● Mechanism of immunological tolerance to autoantigens and immunoregulation● Development and induction of regulatory T cells and their applications● Intracellular signaling in immune disorders● Genomic analyses of rheumatic diseases
Clonal analyses of T cell receptor (TCR) and in vitro● Development of molecular targeting immunosuppressive reagentsreconstitution of the TCR function for an antigen● Airway hypersensitivity and remodeling of bronchial asthma
specific immunotherapy● Mechanisms of IgE mediated allergic disorders and applications for therapies● Involvement of chemokines in allergic diseases and applications to therapeutic strategies●

Infectious Diseases
We are investigating both clinical and basic aspects in infectious diseaes, inparticular, on HIV infection and hepatitis viral infections, the latter of which is
the major cause of liver diseae worldwide. Our research topics cover the wide
areas in microbiology, immunology and pathobilology of infectious diseases,
including HIV and HCV infections.
Clinical studies of HIV infection
Development of new methods in infection control and treatment of viral hepatitis● Molecular pathogenesis of hepatocellular carcinoma in HCV infection● Pathogenesis of extrahepatic manifestations and its control in HCV infection● Pathogenesis of progression of HIV infection● Molecular pathogenesis of hepatocellular carcinoma in HBV infection● Molecular pathogenesis of hepatitis B viral infection● Host defences to microorganisms● Molecular analysis of innate immunity in microorganism infection● Pathogenesis of influenza viral infection● Mechanism of multi-drug resistant microorganisms●●

30

Stress Sciences and Psychosomatic Medicine

http://psmut.umin.ac.jp/

The targets of our laboratory include stress-related diseases such as primaryheadaches and lifestyle-related diseases, eating disorders and malignancies.
The goals of our work are to determine the mechanisms of these conditions, todevelop objective markers for diagnosis and severity, and to discover new
treatment approaches using ecological momentary assessment (EMA),
biochemical assessment of eating-related molecules, and physiologicalassessment of autonomic nervous function.
We are using ecological momentary assessment (EMA) techniques to collectand evaluate subjective and objective data including physical activity andautonomic nervous function in natural settings in stress-related diseases. We
are also developing new treatments using these methods.
● Investigation into the pathophysiology, psychopathology and neurobehavioral
basis of stress-related diseases by use of ecological momentary assessment
methods● Using heart rate and blood pressure variability, we are investigating autonomic
nervous function in eating disorders. This work uses non-linear analyses suchas fractal analysis, as well as linear analysis.
● We have developed an egogram questionnaire, which we refer to as the TEG.
●

Clinical Laboratory Medicine

http://lab-tky.umin.ac.jp/

The main goal of our research projects, described below, is thedevelopment of new and useful laboratory tests, and elucidation ofpathophysiology of diseases through laboratory tests.
Elucidation of (patho)physiological roles of lysophospholipid mediators,
and its application to laboratory medicine● Platelet biology, Hepatology● Genetic testing● Research on bioactive peptides, especially adrenomedullin● Oxidative stress and organ damage● Cell surface analysis and quantification of cell surface antigens using
flow cytometry● Analysis of the ventricle functions using ultrasound● Relationship between the respiratory function and various
pathophysiological conditions● Magnetoencephalographic (MEG) study on neural mechanisms foraudiovisual integration●

Flow cytometer and analysis patterns

Transfusion Medicine

http://square.umin.ac.jp/traf-tky/

Control, testing and supply of all blood products for transfusion are the main clinical activities of the department of transfusion
medicine, which is responsible for the provision of safe blood products and the control of the transfusion practice in the hospital.
It actively takes part in autologous blood collection, preservation, and supply for patients receiving routine surgery. In addition,
apheresis procedures for collection of peripheral blood stem cells for transplantation, and of peripheral blood mononuclear cells
for dendritic cell-based vaccine therapy of cancer patients are performed. Also, lymphocyte-based vaccine is prepared for the
immunotherapy of recurrent abortion cases. Special laboratory testings, including HLA typing (serologic and DNA-based) forbone marrow and organ transplantations and the detection of anti-HLA, anti-platelet (HPA) and anti-granulocyte antibodies, aswell as the phenotyping and genotyping of platelet- and granulocyte-specific antigens for patients with adverse reactions after
transfusion, are performed. The research fields include 1) the development of immunological methods for antigen-antibody
testing of red cells, lymphocytes, granulocytes, platelets and endothelial cells, 2) the development and clinical application ofdendritic cell-based and other vaccines for immunotherapy of cancer, and 3) the development of new anti-thrombotic materials
for clinical use.
Detection of platelet alloantigens and alloantibodies /Detection of leukocyte alloantigens and alloantibodies
Detection of anti-endothelial cell antibodies and investigation on their clinical relevance● Development of a novel method for the evaluation of platelet function● Dendritic cell-based immunotherapy for malignant diseases● Development of new anti-angiogenic strategies to treat cancer● Development of new immunotherapeutic approaches to treat malignant diseases● Development of new anti-thrombotic materials for clinical use /Use of stem cells in regenerative medicine●●

31

Reproductive, Developmental andAging Sciences

Reproductive Endocrinology

http://square.umin.ac.jp/tkyobgyn/

We manage women's reproductive health comprehensively throughout theirrespective life stages (adolescence, reproductive ages, menopause, andpost-menopause). We also aim to develop advanced reproductive
techniques, which could be practiced with higher success rates andimproved safety, based on experimental and clinical research.
Establishment of effective and low-risk treatment for infertility
Development of assisted reproductive technology● Interaction between the endometrium and embryo during the implantation
period● Pathophysiology of endometriosis● Local regulation of folliculogenesis● Technical development of advanced endoscopic surgery● Development of hormone replacement therapy for postmenopausal women● Medical treatment for menopausal women●●

Gynecological Oncology

ICSI (intracytoplasmic sperm injection)

http://square.umin.ac.jp/tkyobgyn/

We are developing the intensive surgical management and selection of
the most suitable chemotherapy regimen, which improved prognosis of
the patients with ovarian cancer. The basic researches are focusing on themechanism of gynecological malignancies, especially cervical cancer. We
have identified the tumor suppressors involving in the process of cervicalcarcinogenesis. We are investigating a possible clinical application of thevaccine against human papillomavirus, which is a causative agent ofcervical cancer.
Intensive surgery including pelvic and paraaortic lymphadenectomy
Selection of adjuvant chemotherapy based on the pathological and molecularmarker● Tumor suppressors involving carcinogenesis of gynecological malignancy● Analysis of the molecular marker in tumor cells related to clinical behavior● Prevention of cervical cancer using the human papillomavirus vaccines●●

Expression of tumor suppressor scribble in malignant cells

32Perinatal Medicine

http://www.iiosan.umin.jp/

The researches are on going for development of precise prenatal
diagnosis on the fetal status using ultrasonography. We are also
focusing on the immunological aspects in patho-physiology ofpregnancy, developing the therapy for habitual abortion or pregnancy
induced hypertension.
Early diagnosis of abnormal pregnancy
Development of three dimensional ultrasonography● Management of habitual abortion● Management of complicated pregnancy●●

Three dimensional ultrasonography of fetus

Molecular Cellular Reproductive Medicine
We are approaching the molecular mechanisms in various
reproductive pathological states, using the knowledge andtechniques of molecular biology, cellular biology and genetics. The
studies are proceeding on the effects of endocrine disruptors on
r e p r o d u c t i v e p h e n o m e n a , s u ch a s e m b r y o g e n e s i s ,spermatogenesis and fetal development, and on the prenatal
genetic diagnosis.
Effect of endocrine disruptors on reproduction◦ Embryogenesis◦ Spermatogenesis◦ Intrauterine fetal development● Prenatal diagnosis using molecular genetics● Molecular mechanisms of embryonic development●

Pediatrics / Developmental Pediatrics

Molecular mechanisms of endocrine disruptors

http://square.umin.ac.jp/ped/

We are studying all the issues concerning the health of infants, children
and adolescents. We have achieved very important investigations toclarify the molecular pathogenesis of human congenital disorders.
Molecular diagnosis and analysis and collaborative treatment of intractable
renal glomerular and tubular diseases● Molecular diagnosis and analysis of hematological malignancy and bonemarrow transplantation● Diagnosis, molecular analysis and collaborative treatment of congenital
heart diseases● Molecular analysis and collaborative treatment of congenital
immunodeficiency and allergic diseases● Collaborative treatment of extremely premature neonates and babies with pulmonary hypoplasia● Enhancement of the immunological resistance of premature neonates using a new type of lactobacillus● Diagnosis and treatment of neurological, endocrine and metabolic diseases● Collaborative study and treatment of psychological disorders● Investigation of new systems to promote mother and baby co-relationships during rearing●

33

Pediatric Surgery
Pediatric surgical diseases have great variety. In our department allkinds of pediatric surgical conditions are treated, and in these fetal
and neonatal surgical care is our main interest. We also treat many
pediatric patients using minimally invasive surgeries such as
laparoscopy and thoracoscopy.
The development and differentiation of the fetal lung
Fetal diagnosis of congenital malformations● Fetal surgery and treatment● Pediatric minimally invasive surgery● Pediatric robotic surgery
EXIT(ex utero intrapartum treatment):Tracheostomy on a fetus● Probiotics and prebiotics applied to padiatric surgical patientswith laryngeal atresia● The development and differentiation of intestinal lymphoid organs● Renal functions in congenital hydronephrosis● Biliary atresia and biliary dilatation: their treatment and long-term prognosis● The treatment by regenerative medicine of air way malacia and stenosis●●

Pediatric Oncology
Solid tumors in children are dealt with in our department.
Appropriate care strategies combining surgical treatment andchemotherapy are decided and carried out on various malignant
tumors after extremely close discussion with pediatric oncologists.
Genetic analysis and investigations for prognostic factors inneuroblastoma● Tumorigenesis in Wilms tumors● Analysis of cellular biology in Wilms tumors● Treatment of rhabdomyosarcoma● Genetic mutation in hepatoblastoma●

Microscopic and ultramicroscopic features of Wilms tumor cell line

Geriatrics
Our department is the first established department of Geriatric Medicine
in Japan. It is our goal to treat all the geriatric diseases, such as
atherosclerosis, hyperlipidemia, osteoporosis, senile dementia, diabetes,
COPD, and aspiration pneumonia, and to improve the quality of life ofelderly patients.
Vascular endothelial function and atherosclerosis
Studies of molecular mechanisms in vascular calcification● Antioxidants inhibit vascular smooth muscle cell proliferation and induce
apoptosis● Vascular gene therapy using adenoviral mediated gene transfer of
estrogen receptors● New guidelines for hormone replacement therapy in females in Japan● Novel gene responsible for breast cancer● Novel gene responsible for osteoporosis● Molecular cloning of novel Ring finger protein● Studies of pathophysiology and novel treatment for Alzheimer's disease● Pathophysiological studies on bronchial asthma using gene-targeted mice
● The antimicrobial peptide, defensin● The molecular mechanisms of vascular injury in sleep apnea syndrome●●34

http://www.h.u-tokyo.ac.jp/patient/depts/1510rounenbyou.html

Surgical Sciences

Thoracic Surgery

http://ctstokyo.umin.ne.jp/

We specialize in surgical treatment for malignant neoplasms of the chest,
such as primary lung cancer, pulmonary metastases, and mediastinal
tumors. Patients with these diseases have been increasing recently in
our country. We actively perform minimally invasive surgery throughthoracoscopy for patients with comorbidities. We also perform extended
surgery with extracorporeal circulation in collaboration with cardiac
surgeons. In 2010 we performed chest surgery for more than 330
patients in our institute. We also study on nonsurgical treatment forpatients with postoperative recurrence of lung cancer or refractory
malignant neoplasms, doing new clinical trials of immunotherapy. In
response to increasing number of brain-death donor in our country, we
are now establishing a lung transplantation program in our institute.
Minimally invasive surgery for chest diseases
Genetic studies on primary lung cancer● Clinical or biological studies on thymic neoplasms● Immunotherapy for lung neoplasms● Basic studies on lung or tracheal transplantation●●

Cardiovascular Surgery

Figure: A case of lung cancer with interstitial pneumonia.
(left upper) High-resolution Computed Tomography(left lower) Axial section of 18F-FDG-PET(right upper) Frontal section of 18F-FDG-PET(right lower)resected specimen

http://ctstokyo.umin.ne.jp/

We are leading in Japan by annual surgery case volume of 400.
New knowledge and techniques are actively applied clinically.
Many clinical research projects are going on along with routine
clinical activities. Our laboratories have been also carrying out alarge variety of basic research.
Clinical research◦ Brain and spinal cord protection in thoracic aortic surgery◦ Minimally invasive cardiac◦ Valve or vascular tissue allograft transplantation◦ Ventricular assist device for end-stage heart failure● Basic and experimental research◦ Development of myocardial regeneration therapy◦ Analysis of resistance to infection of tissue allograft●

MRI diffusion-weighed images of brain by various brain perfusion techniques

35

Gastrointestinal Surgery

http://todai3ge.umin.jp/

Our research activities range from basic topics to clinical ones with closeinterconnections. Basic research topics encompass underlying molecularmechanisms and the regulation of carcinogenesis, progression, metastasis andprevention of gastrointestinal cancer. Clinical research topics include theestablishment of tailored treatment strategies from a patients-by-patient point ofview, which ultimately provide a better quality of life while improving survival
quality.
Carcinogenesis, progression, metastasis and prevention of gastrointestinal cancer◦ Inflammation and gastrointestinal carcinogenesis (gastroduodenal reflux, H. pylori infection)◦ Are cancer cells derived from bone marrow?
◦ Earlier detection of cancer and micrometastasis by new genetic markers◦ Roles of epigenetic alteration (DNA methylation) in gastrointestinal carcinogenesis◦ Carcinogenic analysis with murine esophageal reflux model● Establishment of tailored treatment strategies◦ Less invasive treatment of early cancer by laparoscopic (assisted) surgery◦ Sentinel node navigation surgery for early cancer◦ Extended radical treatment of advanced cancer◦ Induction of neaoadjuvant chemotherapy and improvement of survival◦ Estimation of chemotherapy effects by new bio- and genetic-markers◦ Alternative gastrointestinal reconstruction and estimation of the results●

Hepatobiliary Pancreatic Surgery

Barett's esophagus and Cancer in reflux
model mouse

http://square.umin.ac.jp/hbp-t/index21.htm

We constantly perfom nearly 200 hepatectomies every year on patients with
hepatobiliary malignancies including hepatocellular carcinoma andmetastatic liver tumors. The surgical results can be classified as amongst thehighest ranking in the world. In order to improve the surgical outcome forhepato-biliary-pancreatic malignancies, we conduct wide areas of researchsuch as analysis of prognostic factors for liver malignancies, evaluation ofliver hemodynamics using ultrasonography, liver ischemia/reperfusion
injury, and liver regeneration.
The development of a radical and safe operative procedure for hepato-biliary malignancies● The analysis of genetic abnormalities in hepatocellular carcinoma● Development of new methods for the evaluation of liver functional reserve● The evaluation of hemodynamics in the congested liver using ultrasonography● Study of the effect of ischemic preconditioning on liver normothermic ischemia/reperfusion● Study of intraoperative diagnosis (enhanced ultrasound and ICG fluorescent imaging)● Clinical trials concerning adjuvant therapies after hepatic resection for hepatocellular
carcinoma (HCC) or colorectal liver metastasis● RCT to evaluate the effects of surgical resection and RFA for HCC (SURF trial)● Investigation of adjuvant immunotherapies after surgery for pancreato-biliary malignant
tumors●Urology
We constantly perform more than 1,400 urological surgeries every year,
including nephrectomy, cystectomy and prostatectomy, with increasing trend of
laparoscopic maneuvers. Robotic surgery will be introduced in 2011. Surgical or
non-surgical means are employed for non-cancer disease including chronic
renal failure, urinary dysfunction, urinary incontinence and interstitial cystitis.
With regard to basic research and treatment, vaccine, dendritic cell, virus,
prevention drugs, tumor suppressor, bio-marker and Botulinum toxin injection
are now under extensive investigation.

Color flow mapping of intra- Color flow mapping of intraoperative Doppler ultraoperative Doppler ultrasonography before division sonography after transectionof the middle hepatic vein. of the middle hepatic vein.
Portal flow was hepatopetal Portal flow was hepatofugal(shown in blue) in the veno(shown in red).
occlusive area.
Preoperative 3-D
image of the liver
constructed bysimulation software.
Accurate anatomy ofvasculatature andtumor location isanalyzed.

http://www.h.u-tokyo.ac.jp/urology/

Fig.1 The combination therapy of oncolytic HSV-1 with androgen
ablation led to significantly enhanced inhibition of the tumor growth.

Vaccine against NY antibody for bladder cancer treatment
Botulinum toxin injection therapy for interstitial cystitis● Dendritic cell therapy for metastatic renal cancer● Investigation of bio-marker for renal cancer and interstitial cystitis● Advanced therapy for male urinary incontinence● Virus therapy for prostate cancer and bladder cancer (Fig.1)● Tumor suppressor gene for renal cancer, bladder cancer and prostate cancer● Prevention drugs for prostate cancer● Prostate cancer and ER beta (Fig.2)
Fig.2 Expression of KLF5/ERbeta is correlated with prostate cancer specific survival●●

36

Artificial Organ and Transplantation Division

http://www.h.u-tokyo.ac.jp/patient/depts/1512ishokugeka.html

We are doing the clinical studies about liver transplantation for end
staged liver diseases. We have performed 471 living donor livertransplantation and 14 deceased donor liver transplantation until
June, 2011.
Surgical technique of liver transplantation
Diagnosis and treatment of acute rejection● Diagnosis and treatment of postoperative infection●●

The 5-year survival rate for adult cases was 85%, which issignificantly superior to that of the national data (70%)

Surgical Oncology

http://all-1su.umin.jp/

We had a great deal of experience in treating patients with various cancers
and vascular diseases, and we have performed much research on
carcinogenesis, cancer metastasis, immunology, atherosclerosis,
angiogenesis and vascular regeneration. Based on the research results, weare trying to identify the best way to treat each patient with the least surgicalstress.
Development of the novel and order-made therapy for cancer◦ Genetic mutation analysis of various cancers◦ Radiosensitivity and chemosensitivity of cancer◦ Intraperitoneal chemotherapy for peritoneal carcinomatosis◦ Immunotherapy using dendritic cells◦ Characterization of tumor vasculature and its therapeutic application◦ Gene therapy for disseminated metastasis◦ Drug development to target the receptor and signal transduction cascadeof bioactive lipids◦ Development of chemoradioimmunotherapy

Vascular Surgery

Diagramatic representation of clinical-oriented research,with the ultimate goal of improving patient QOL

http://all-1su.umin.jp/

We had a great deal of experience in treating patients with various
vascular diseases, and we have performed much research on
atherosclerosis, angiogenesis and vascular regeneration. Based on the
research results, we are trying to identify the best way to treat eachpatient with the least surgical stress.
●

Development of a novel method to diagnose and treat the vasculardiseases.
◦ Vascular regeneration therapy for atherosclerotic obliterans◦ Navigation system for less invasive vascular surgery◦ Analysis of intermittent claudication with dynamic and mechanicalmodel◦ Dynamic and genetic mechanism of aortic aneurysm expansion◦ Development of the new prosthesis with small diameter◦ Hemodynamic analysis of aortic wall after endovascular aneurysm
repair◦ Drug delivery system for aortic aneurysm and peripheral arterial
disease37

Metabolic Care and Endocrine Surgery

http://todai3ge.umin.jp/

Our department has two main divisions. Division of surgical metabolism andnutrition performs research on vital response to surgical stress and on metabolicand nutritional care during peri-surgical period. Division of breast and endocrine
surgery performs surgery for 230 cases of breast, thyroid and parathyroid
tumors a year, and performs research on tumorigenesis, establishment oftreatment and prevention of breast and thyroid cancers.
Surgical metabolism and nutrition◦ Induction of tolerance against surgical stress and endotoxemia◦ Response to endotoxemia through Toll-like receptors◦ Effects of surgical stress on tumor development◦ Gender difference in the response to surgical stress◦ Bacterial translocation during chemotherapy for cancer◦ Establishment of metabolic care and nutritional support team● Breast and endocrine surgery◦ Roles of nuclear receptor in development of breast cancer◦ Micrometastasis of breast cancer◦ Diagnosis of breast and thyroid tumors by fluorescence in situ hybridization of telomere◦ Expression of insulin-like growth factor 1 receptor in breast cancer tissue as prognostic factor◦ Roles of carbohydrate in breast cancer metastasis◦ Establishment of evaluation on QOL of the patients with breast cancer●

Dermatology

Detection of telomere and centromere by Fish. Fluorescencevolume of telomere attenuates with increase of cell division.
(red: telomere, green: centromere, blue: chromosome)

http://www.h.u-tokyo.ac.jp/der/Our department actively performs the following cutting-edge, multifaceted
research projects that will be put into clinical practice in the future.
Molecular mechanisms of immunological abnormalities and skin and lung fibrosis
in scleroderma● Development of novel therapies to scleroderma, including B cell depletion therapy● Relative contribution of various cell adhesion molecules and chemokines toinflammatory conditions● Identification of novel autoantibodies and their clinical significance in connective
tissue diseases● New roles of B lymphocytes, especially regulatory roles, in inflammatory
disorders● Immunological abnormalities of atopic dermatitis●

Skin fibrosis induced by bleomycin(left) is inhibited in
CD19-deficient mice(right)

Plastic and Reconstructive Surgery
In our lab, we are investigating the mechanisms of morphogenesis ofcongenital anomalies using a developmental biological approach. In
addition, we are performing extensive research into the clinicalapplication of engineered tissues such as skin, soft tissue, and cartilage.
We also have several cosmesis-related projects such as clinical hairregrowth with cultured cells and analysis of skin aging mechanisms.
●

Basic Research◦ Mesenchymal stem cells derived from lipoaspirates◦ Organ engineering with human adult stem cells◦ Hair regrowth with cultured dermal papilla cells ◦ Research on aging skinrelated factors ◦ Regulation of skin aging using hormones and retinoids
Supermicrosurgical vascularized nerve graft. 100% of◦ Regulation of epidermis by factors derived from dermal fibroblasts
Schwan cells within a nerve graft can survive with
● Clinical Research
microvascular anastomosis(0.5mm).
◦ Ultramicrosurgical reconstruction using vascularized tissue transfers◦ Reconstructions for established nerve palsy ◦ Esthetic microneurovascular surgery◦ Mechanism and surgical treatments of lymphedema ◦ Vascularized ovarial preservation and transplantation◦ Free vascularized transfers of nerve cells, muscle cells, adiposal cells, and lymphnodes◦ Allogenic tissue transfer (uterus, ovarium, anus etc.) ◦ Training method for supermicrosurgical anastomosis

38

Oral and Maxillofacial Surgery

http://plaza.umin.ac.jp/˜oralsurg/

Our laboratory has been performing a wide range of clinically oriented researchin oral-maxillofacial disorders such as congenital diseases, jaw deformities andtumors in the oral region. Cartilage and bone regeneration using tissue
engineering techniques is our main field of research.
Clinical research:◦ Correction of facial deformity in patients with cleft lip and palate◦ Facial growth in craniofacial anomalies◦ Surgical-orthodontic treatment of dentofacial deformities◦ Evaluation of the treatment outcomes in patients with cleft lip and/or palate◦ Clinical application of artificial bone that displace into bone
◦ Implant type artificial bone generated from tissue engineered human chondrocyte● Basic and experimental research:
Cartilage and bone regeneration using the tissue◦ Cartilage and bone regeneration using the tissue engineering techniqueengineering technique◦ Gene analysis of congenital anomalies in the oral and maxillofacial region◦ Effect of free radicals on bone metabolism◦ COX-2 regulation on bone metabolism◦ Development of intelligent type of artificial bone invested with osteogenic differentiation factors◦ Development of tetra pod type micro artificial bone unit●

Orthopaedic Surgery

http://www.h.u-tokyo.ac.jp/ortho/

Our department was established in 1906 as the first department oforthopaedic surgery in Japan. Since then our efforts have been dedicated toresponding to the needs of patients for orthopaedic care and to related
research. Our department seeks to elucidate the molecular and genetic
backgrounds of bone and cartilage disorders in order to develop
groundbreaking treatments for these conditions. At the same time, we areattempting to establish various clinical devices.
Systemic and comprehensive study for osteoarthritis
Bone, cartilage and nerve regeneration
Surgical navigation system● Regulation of anabolic and catabolic bone metabolism by cytokines● Molecular mechanism of age-related bone loss
● Molecular mechanism of osteoclast differentiation and apoptosis (RANKL-RANK, INF, Src)
● Gene therapy to control pathological bone destruction (arthritic bone resorption and arthritic joint destruction)using adenovirus vectors● Non-invasive analyzing system to evaluate the mechanical properties of skeletal system in vivo using CT based
finite element analyses● Surgical navigation system with a three-dimensional display and navigation robot●●

Ophthalmology

http://plaza.umin.ac.jp/oph/

Our department applies cutting-edge technologies and knowledge todiagnosis and treatment of eye diseases. To elucidate pathogenesis andestablish more efficient ways of diagnosis and treatment of various
refractory eye diseases, basic researches utilizing molecular biological,
immunological and/or pharmacological techniques and clinical studies
utilizing epidemiological, biostatistical and/or optical methods are conducted.
Our efforts are also dedicated to regenerative medicine of the cornea andretina.
Investigation of primary glaucomas and relating factors
Development of new methods of glaucoma treatment and validation by RCT● Investigation of new ocular hypotensive drugs and their mechanism of action byusing transgenic or KO mice or experimental glaucoma monkeys● Investigation of mechanism of neural cell death by using cultured RGCs or retinal
glial cells and exploratory search for new neuroprotective agents● Analysis of ocular circulation in glaucoma and retinal diseases● Analysis of corneal topography and wave-front analysis of optical aberrations● Development of tissue-engineered cornea by using cultured stem cells of corneal endothelium and epithelium● Investigation of molecular mechanism of choroid-retinal neovascularization and new drug delivery system for it utilizing nanotechnology● Regenerative medicine of the retina using retinal stem cells● Investigation of immune responses in rejection of transplanted cornea and role of chemokines and receptors in uveitis●●

39

Otorhinolaryngology and Head & Neck Surgery

http://www.h.u-tokyo.ac.jp/orl/

Our research is composed of both clinical and basic research. Clinical research is
conducted by specialized clinics in the hospital, which experience ear diseases andhearing disorders from neonates to adulthood, head and neck cancer, paranasal
diseases, olfactory and disorders, vertigo and balance disorders and voice andswallowing disorders. Basic and experimental research into molecular biology,
electrophysiology and morphology is conducted in our department's laboratories.
●●

Clinical research◦ Cochlear implantation in deaf children and their development of hearing, speech and language◦ Surgical correction of congenial microtia and atresia and postoperative radical ears to improve hearing◦ Quality of life in patients with head and neck cancer to restore speech and swallowing function◦ Vestibular research on the oculomotor and balance system and myogenic potential◦ Navigation of the paranasal sinuses and skull base surgery◦ Surgical treatment of voice and swallowing disorders

Basic and experimental research◦ Molecular biology of the inner ear◦ Molecular biology of pharyngeal cancer◦ Molecular biology of differentiation and development of inner ear and olfactory epithelium◦ Origins of vestibular myogenic potential◦ Aging and regeneration of olfactory epithelium◦ Physiology of vocal cord vibration

Chochlear implant

Rehabilitation Medicine
Our research purpose is to improve the provision of a unique andcomprehensive rehabilitation service enabling people to develop
their full potential and often returning from being a "patient" to beinga "person". Clinically oriented studies concentrate on elucidation of
the origin of disabilities to cause activity limitation and restriction ofparticipation.
Gait analysis◦ 3-dimensional image analysis with a infrared camera system◦ Measurements of 3 dimensional ground reaction forces with a force platform◦ Measurements of foot pressures with a computerised pressure sensor● Clinical research on intractable rare diseases◦ Fibrodysplasia Ossificans Progressiva◦ Congenital Insensitivity to Plan
● Clinical research on congenital limb malformations● Research on the effect of physical therapy in locomotive syndrome●

Anesthesiology

Gait analysis

http://www.anes.umin.ne.jp/

We have seven research groups and their fields include respiration,
circulation, pain, immune system and shock.
These are recent major subjects of our research.
Respiratory system: A role of cytokine signaling in acute lung injury; Exploring
optimal ventilatory strategy for respiratory failure● Immune systems: Modification of immune system by anesthesia; Signaltransduction pathway related to apoptosis induced by sepsis or ischemiareperfusion injury● Shock: Investigation of pathophysiology of shock; Effect of new plasma
substitutes on hemorrhagic shock.
● Inflammation: A role of lipid mediators in organ damage mediated by ischemiaAnesthesia and monitors
reperfusion injury of a mouse lower limb.
● Pain: A role of lipid mediators in the formation of hyperalgesia; A role of spinal microglial cells in the development of inflammationmediated neuropathic pain; Mechanism of pruritoceptive and neurogenic Itch; Cognitive-behavioral therapy on chronic pain.
● Nervous system: Analysis of electroencephalography during general anesthesia; Clinical evaluation of neurological sequelae after
cardiac surgery.
● Anesthesia apparatus and other medical equipment: Invention and validation of a new airway device; Development and assessmentof the system for treating waste anesthetic gases● Glucose metabolism: Effect of anesthetics on glucose metabolism in vivo●

40

Emergency and Critical Care Medicine
We are collaborating with the School of Engineering, and now
concentrating on the development of the infrastructure of
emergency medicine including "the Vital Care Network
System", which allows us to manage continuously large
numbers of high risk patients. We are also making efforts toimprove sterilization and wound healing.
Vital Care Network System
Telemonitoring system for prehospital medicine● High-performance transfer system for the ambulances● Electrolyzed water● Autonomic nervous system regulation of the heart●●

41

Health Sciences and Nursing

Mental Health / Psychiatric Nursing
Our departments conduct research on mental health and psycho-social
stress and provide education/ training of professionals in related fields
from global perspectives.
Mental Health◦ Mental health epidemiology◦ Occupational mental health/Occupational health psychology◦ Psychoeducation/Stress management◦ Evaluation of school counseling◦ Practice and Evaluation of Psychotherapy◦ Early detection and therapeutic education of PDD● Psychiatric Nursing◦ Supporting people living with mental health problems◦ Practice and evaluation of home visiting psychiatric nursing◦ Illness self-management in mental health◦ Recovery for people with mental illness◦ Patients' satisfaction with psychiatric services●

Biostatistics / Epidemiology and Preventive Health Sciences
Biostatistics and epidemiology provide the methodological basis forhealth sciences. We are conducting basic methodological research of
biostatistics and theoretical epidemiology as well as consultation works
and collaborative projects with basic/clinical researchers. The NPO"Japan Clinical Research Support Unit" established by the staff of thedepartment is supporting investigator-initiated clinical trials and largescale epidemiological studies in respect of data management, statistics
and quality assurance.
●

Methodological research◦ Design of clinical trials◦ Analysis of correlated data and longitudinal data such as QOL data,
multiple recurrence (events) data

◦ Causal inference● Collaborative projects◦ Japan Arteriosclerosis Longitudinal Study◦ Comprehensive Support Project for Oncology Research- Breast Cancer◦ Comprehensive Support Project for Adequate Treatment of Osteoporosis◦ Other investigator-initiated clinical trials

42

http://www.epistat.m.u-tokyo.ac.jp/

http://www.sg.m.u-tokyo.ac.jp/
informatione.htm

Social Gerontology
The three major research areas of this department include social
gerontology, psychosocial oncology and biomedical ethics. The faculty
and graduate students are multidisciplinary and include those whose
primary training is in nursing, medicine, psychology, anthropology andhealth sciences. Using the theories and research methods of thosedisciplines, we aim to suggest practical ways to deal with a wide
variety of public health problems.
Exchange of social support and subjective well-being among the elderly
Psychological well-being among the elderly who have experienced
relocation● Measurement of active life expectancy● Sexuality and body image issues related to cancer treatments● Treatment decision-making process among cancer survivors● Self-help group activities for chronic, life-threatening illnesses● Psychosocial issues related to infertility treatments● Multi-disciplinary collaboration in the clinical setting●●

Health Promotion Sciences

Class meeting of the department

http://www.ethps.m.u-tokyo.ac.jp/

The main research activities of the Department of Health Promotion
Sciences are experimental and survey research concerning healthbehavior and life-style related diseases. Our research results contributeto the proposals of health care systems, and health policy concerning
health promotion in the community and the workplace.
Our classes include lectures and practical training and students are
required to understand the methods of planning, implementation andevaluation of the health promotion programs in the community andthe workplace.
Specific research topics include:● Development of effective health promotion programs● Assessment of the supportive environments in the community and theworkplace
A scene as part of a community health promotion program● Evaluation of the supporting methods for health behaviors● Short- and long-term effects of behavior change● Influence of behavior change on medical costs, and cost effectiveness analysis● Social and physical environmental determinants of the adherence of behavior change

Biomedical Ethics

http://www.ethps.m.u-tokyo.ac.jp/

The Department of Biomedical Ethics conducts both theoreticaland empirical studies in the fields of biomedical ethics, research
ethics and clinical ethics. Research topics include ethical theories,
informed consent, ethics committees and organ transplantation.
The Center for Biomedical Ethics and Law (CBEL) was recently set
up as an adjunct to the Department of Biomedical Ethics.
(http://www.cbel.jp/)
Study of the functions and responsibilities of ethics committees inJapan● Study of the methods for the formation of social consensus related
to advanced medical technology● Comparative study of clinical ethics in the Asian region● Publication of a medical ethics case book for Japan● Acceptability of advance directives in Japan● Development of evaluation methods for biomedical ethics education● Psychosocial and ethical aspects of living related organtransplantation●

Outreach Program: CBEL provides training courses for ethics committee
members. Participants include physicians, nurses and medical
pharmaceutical representatives.

43

Nursing Administration / Advanced Clinical Nursing

http://nurs-adm.umin.jp/

Our research programs aim to support clinical nurses in providing highquality care for their patients in efficient way. Under a nation-wide
healthcare reform, improving the efficiency of healthcare delivery
systems becomes essential. For nursing care, assessing the efficacy
and the putting in place of quality assurance systems are required.
Applying management theories to nursing administration, we focus on
nursing quality improvement, nurse staffing, patient classification
systems, budgetary management, staff development and continuing
education.
Evaluation and improvement of quality of nursing care
Benchmarking of nursing quality indicators● Outcome management for nursing practice● Risk management● Human resources management● Nursing case management and critical pathways● Effect of care environment on patients● International comparison of nursing quality indicators● Nursing policy and economics●●

Promoting quality nursing care

Family Nursing
Hand-in-hand with the changes occurring in society, such as declining birthrate
and a growing proportion of elderly people, vulnerability of regional network,and gender-equal society, the conformation and the function of the family arealso changing. Current Japanese society expects not only client-centeredperspective but also a perspective to refer family as ‘client’ in the nursing
research. We are especially performing research on childrearing issues andcaring for child with illness.
Postnatal depression and difficulties in childrearing.
Prevention of child abuse and neglect.
● Development of Pediatric QOL Inventory for child with chronic illness and their parents.
● Late effect of treatment and posttraumatic stress symptoms in children with cancer.
● The role and expertise of the nursing staffs in daycare centers.
● Primary caregivers’ burden of the severely disabled children and the utilization of therespite care.
● Care for dying patients and their families (QOL, family function).
● Development of Japanese version of Families Importance in Nursing Care-Nurses’
Attitudes.
●●

Community Health Nursing

http://park.itc.u-tokyo.ac.jp/chn/english/index.html

Our research focuses on the development of health care programs, andestablishment and evaluation of community health care systems, in
response to the health care needs of individuals, families, aggregates
and the communities. Also, we are performing research on
standardization of skills of public health nurses.
Establishment and evaluation of community health care systems◦ Around-the-clock in-home care system◦ Expansion of the target of visiting nurse◦ Hospital discharge planning◦ Comprehensive community care, care-networking● Development of health care programs◦ Support for people with diseases or disabilities◦ Support for families with babies and children◦ Elderly care
Concepts of the Community Health Nursing◦ Occupational health● Definition and standardization of skills of public health nurses/ Development of community health program●

44

Adult Nursing / Palliative Care Nursing

http://www.adng.m.u-tokyo.ac.jp/indexe.htm

Mainly for subjects in their adulthood, we have been performing
research in a variety of domains including prevention ofdiabetes and several chronic illnesses, support for coexistencewith disease, and palliative care. Focal points in our research,which we conduct under a team approach, are strategies in
education and provision of relevant information based on thefindings of molecular biology, and the team-approach nursing
care system.
Prevention and self care support for chronic illness
Development of HR-QoL scale for patients with chronic illness● Physical activity in middle- aged / elderly● Nursing care system for transplantation recipient / donor● Genetic counseling in nursing● Evaluation of palliative care services● Continuity and dissemination of palliative care
● Nursing care system for out patients●●

http://park.itc.u-tokyo.ac.jp/
midwifery/index1eng.htm

Midwifery and Women's Health
The Department of Midwifery and Women’s Health was founded in 2002. Our
mission is to promote women’s health across the lifespan, which includes
reproductive and postmenopausal periods. Specifically, we include the fetus
and newborns as inseparable being of the mother. Our department focuses
our efforts in research in the following areas:
Effects of prenatal lifestyle modifications on the maternal oxidative stress.
Maternal body composition and the birth outcomes.
● Dietary and weight management during pregnancy and postpartum for cardiovascular
health.
● Uterine biomarkers and prediction of labor progression.
● Fear of childbirth among pre- and postnatal Japanese women.
● Ergonomics of perinatal women’s posture and their effects on the pelvic floor andsupporting muscles.
● Stress urinary incontinence and the pelvic floor and abdominal muscles among womenacross lifespan.
● Development of the behavior interventions to promote the pelvic floor health.
●●Photo by Sakae Kikuchi

Gerontological Nursing / Wound Care Management

http://www.rounenkango.m.u-tokyo.ac.jp/
english/index-e.html

Pressure ulcers and diabetic foot ulcers usually occur in elderly people due
to basic activities of daily living such as walking, sleeping, diet andexcretion. Thus their supports are inevitable for comprehensive woundcare management. Especially, diabetes mellitus, nutrition, and skin careare of importance for wound healing, hence we account for these keys todevelop wound care technologies and devices. Our department address
the new concept of nursing science, ”Bioengineering Nursing”, in which
the basic science will be translated into clinical science throughco-development of new technologies and devices with specializedengineers.
●

Development and evaluation of wound management technology and devices◦ Elucidation of pathophysiology and its diagnosis technology of wound◦ Development of technology and devices for wound management andprevention◦ Evaluation of new technology and devices◦ Investigation of bioengineering aspect of elderly skin
◦ Exploring of objective parameter of skin status◦ Development of intervention methodology for improving skin function

Example of Bioengineering Nursing research in our department.
–Investigation of mechanism for deep tissue injury and its
effective management strategy–

45

International Health

Global Health Policy

http://www.ghp.m.u-tokyo.ac.jp

Our mission is to improve population health by enhancing accountability
and improving the evidence base of global (both domestic andinternational) health programs through the provision of the best possible
information and rigorous monitoring and evaluation. The department's
members generate knowledge and ideas through their research, strengthen
technical and leadership skills through educational programs, and enhancenational capacities through collaborative projects, especially in thedeveloping world.
The priority areas of research are:
1. Health outcomes (mortality, morbidity and disability), health services, cost-effectiveness of interventions, disease modeling,
resource flows, and impact evaluation, including tracking the progress towards the Millennium Development Goals andcontributing to the Global Burden of Disease study);
2. Health system performance assessment, including the analysis of health system inputs (evidence on financing and humanresources), outputs (service delivery, effective coverage), and impact (health status); and3. Health and foreign policy (e.g. global health architecture and governance, G8 and global health, donor commitments).
Finally, the fundamental role of the Department is to produce the next generation of leaders in global health.

Community and Global Health
Our Department aims at bringing together clinical, public health and social
science research to address following aspects of international health. We
also conduct international cooperation activities with the U.N., JICA, local
government and NGOs in developing countries. Our educational activities
provide practical trainings for students, who are enthusiastic about
contributing to research in international health and to international
cooperation.
Health promotion in developing countries
Health and human rights● Health and human security● School health● Infectious diseases (HIV/AIDS, TB, Malaria etc.)● Nutrition● Health policy and its impact on health of community people● Global health workforce policy●●

46

http://www.ich.m.u-tokyo.ac.jp/

Human Genetics

http://www.humgenet.m.u-tokyo.ac.jp/

Department of Human Genetics is broadly interested in thehuman genome diversity, especially in the Asian populations.
Specifically, we are using genomic research tools including SNP
and microsatellite analyses, as well as gene expression profiling,
to better understand the genetic background of a variety ofcomplex diseases, especially bone and joint diseases, infectious
diseases and sleep disorders.
●Theoretical and experimental analyses on the genetics of complex
diseases◦ Development of statistical approaches for susceptibility gene
mapping in complex diseases◦ Comprehensive genetics of bone and joint diseases◦ Host susceptibility factors to infectious diseases◦ Molecular mechanisms of sleep disorders● Development of new methodologies for genomic polymorphism● Analysis on the genome diversity of Asia-Pacific populations● Development of methodologies for the analysis of protein interactions

Developmental Medical Sciences
Founded in 1966 as the Department of Maternal and Child Health,this department has devoted itself to the research and education on
the maintenance and promotion of mothers' and children's health,including studies of infectious diseases, nutritional disorders andcongenital anomalies. At present, the main research activities areexperimental and epidemiological studies on the etiology (genetic
and environmental factors), pathogenesis, prevention andtreatment of various childhood brain disorders (congenital andacquired) that cause mental and motor disabilities and epilepsy,
from the viewpoint of international health science anddevelopmental neuroscience.
Studies on developmental brain disorders◦ Abnormal neuronal differentiation and size control (tuberous sclerosis)◦ Neuronal migration disorders (lissencephaly, polymicrogyria)◦ Perinatal brain injury (periventricular leukomalacia)◦ Postnatal brain injury (acute encephalopathy)◦ Inherited metabolic disorders (peroxisomal and mitochondrial disorders)● Molecular epidemiology of infectious diseases (diarrheal viruses)● Field studies of maternal and child health (malnutrition, obesity)●

Inhibition of doubledortin expression by shRNA reduces the distanceof neuronal migration from the ventricular zone to cortical plate.

Human Ecology

http://www.humeco.m.u-tokyo.ac.jp/

Ecological understanding of health and survival of contemporary humanpopulations through the analyses of nutritional, demographic, andenvironmental aspects of each population is our primary goal. Bothfieldworks on various Asia-Oceania populations as well as experimental
studies dealing with nutrition and environmental chemicals are conducted,
which would serves as the basis in challenging the International Healthissues.
Mechanistic analyses of the effect of subsistence transitions on the healthand environment in rural and urban communities in developing countries● Application of GPS, GIS, and remote sensing to health ecology andAt a school in a survey area, West Java, Indonesia
international health● Exposure-effects evaluation of chemical pollution of watershed in rural Indonesian children● Nutritional ecology, subsistence ecology, medical anthropology and biological demography in Asia-Oceania populations● Development effects of perinatal exposures to heavy metals, pesticides, or endocrine disrupting chemicals● Modulating effects of nutrients and nutritional status on environmental hazardous chemicals● Sustainable society and health●47

Biomedical Chemistry
The aim of our department is to contribute to the overall global health andwelfare through basic research. Our current interests are: the energy
metabolism of humans, parasites, and bacteria; and RNA and RNAbinding proteins.
Human succinate dehydrogenase complex and mitochondrial myopathy
Ascaris suum and Caenorhabditis elegans● Molecular mechanism of adaptation to low oxygen tension● Mitochondrial quinol-fumarate reductase● C. elegans as a model system of parasitic nematodes and ageing● Malaria and Trypanosome: characterization of mitochondria as a target forchemotherapy● Escherichia coli and Mycobacterium: respiratory enzymes and regulation ofenergy supply● RNA and RNA-binding proteins● Mitochondriral translation system● RNA biogenesis of Eukarya and Archaea●●

48

Free-living nematode Caenorhabditis elegans expressing a
recombinant green fluorescent protein inside the body under
the control of the promoter of the iron-sulfur subunit (Ip)gene of succinate-ubiquinone reductase (complex II)

School of Public HealthSocial and Preventive Epidemiology
Our main research field is preventive epidemiology onlifestyle-related diseases. This department is unique inJapan since our core research field is "nutritional
epidemiology", which epidemiologically examines theroles of diets for disease prevention and control.
Methodological studies on dietary assessments
Nutritional epidemiologic studies on nutrient intakes/dietarybehaviors and health status● Studies on development of dietary promotion methods andevaluation of their effectiveness● Establishment of literature database for "epidemiologic
studies on diets and health"● Collaborative studies with clinical trial groups on nutritionrelated diseases●●

Health Economics and Epidemiology Research
The department purports to help students become ahealth service practitioner with a sound theoretical andscientific ground underscored by quantitative methods of
epidemiology and economics. The department will also
contribute to the society through conducting empiricalassessment of health practice and policy on the themes
such as;Economic assessment of medical technology
Clinical evaluation through patient-derived outcome● Standardization and management of quality of care
● Health policy assessment● Health impact of socio-economic policy
●
●

Japan

USA

Japan

USA

Comparison of quality of primary care; Japan vs. U.S. Hashimoto, et al. Lancet 201149

Health Communication
The Department of Health Communication conducts research on the
University hospital Medical Information Network (UMIN) Center related
activities as well as health communication research at various levels.
Main research topics include;● Communication of health information to general public● Patient-provider relationship and communication● Health literacy● Activities related to the UMIN
● Information systems for clinical epidemiologic studies● Security of the information network

Clinical Information Engineering
Clinical Information Engineering is a combination of information science,computer science, and clinical science designed to assist in the management
and processing of data, information and knowledge to support the practiceand delivery of biomedical research and clinical care.
Medical Decision Making
Cancer informatics● Data Mining & Knowledge Discovery in Database● Virtual reality for medical science● Social information engineering for Public Health(Public Health Informatics : PHI )●●A virtual reality application for medical decision making

School of Public Health
Biostatistics See Biostatistics / Epidemiology and preventive Health Sciences(p42)
Mental Health See Mental Health / Psychiatric Nursing(p42)
Social Gerontology See Social Gerontology(p43)
Health Promotion Science See Health Promotion Sciences(p43)
Biomedical Ethics See Biomedical Ethics(p43)
Health Policy See Public Health(p26)
Health Informatics See Medical Informatics and Economics(p27)
Forensic Medicine and Medical Law See Forensic Medicine(p27)50

Center for
Disease Biology and Integrative Medicine

Molecular Biomedicine for Pathogenesis

http://www.cdbim.m.u-tokyo.ac.jp/
english/index.html

Focusing on functional analysis of newly isolated genes, particularly
related to apoptosis, cell differentiation, or cell cycle, our laboratory is
pursuing clarification of the pathogenesis of various diseases and therelated physiological machineries in cellular and molecular aspects.
Based on our technical advantage in gene manipulation via geneknockout and transgenesis, we give high priorities to in vivo analyses.
Our overall goal is to apply our findings to development of novel anddefinitive therapies for types of diseases.
Role of AIM (Apoptosis Inhibitor of Macrophage) in atherosclerosis
development and other diseases● Regulation of hematopoiesis and its relevance to leukemogenesis; via
functional analysis of a newly identified Polycomb group molecule MBT-1● Regulation of tumorgenesis by modulating apoptosis and cell cycle; via
analysis of DEDD-deficient animals●

Structual Physiology

http://www.bm2.m.u-tokyo.ac.jp/index-e.html

We have been exploring two-photon excitation microscopy, which
utilizes an infrared femtosecond-pulsed laser as a light source, tovisualize and stimulate intact tissues at the cellular and molecularlevels. We focus on the functions and disorders of the brain andsecretory organs.
The dynamics of synapses in the cerebral cortex, in relation to memory,
cognitive processes and mental disorders● Molecular mechanisms of exocytosis in synapses and the islet of
Langerhans, and their optical control●

Fine structure and function of a central neuron studied
with two-photon excitation imaging and uncaging

51

Regenerative Medical Engineering

http://www.cdbim.m.u-tokyo.ac.jp/

We aim to create a basic methodology for tissue engineering by integrating
engineering sciences such as mechanical, material, and chemical systemengineering into basic and clinical medicine. Especially for the regeneration ofbones, cartilages, and blood vessels, we focus on cellular response to physicalstimulations, which can be utilized instead of growth factors and cytokines. In
addition, fabrication of new biomaterials is important. We develop new
biocompatible hydrogels based on polysaccharides, hyperbranched polymers,
and DNA analogues, which materials are applied to drug delivery systems for
peritoneal diseases, artificial red blood cells, and artificial pancreas islets.

Ushida Lab

Ito LabDevelopment of new polymeric and inorganic biomaterials for regenerative medicine
In vitro regeneration of carriages, bones, and small blood vessels● Mechanism of cellular response to physical stimulations● Fabrication of new biocompatible hydrogels● Development of anti-peritoneal adhesion barrier and drug delivery system for
peritoneal diseases● Development of artificial pancreatic islet by a microcapsulation technique, anddevelopment of artificial red blood cells by a membrane emulsification technique●●

Clinical Biotechnology

http://www.bmw.t.u-tokyo.ac.jp/english/index.html
http://www.cdbim.m.u-tokyo.ac.jp/english/
research/01_04.html
Nanodevices produced by nanotechnology integrate materials and systems on
a nanometer scale, and hold the key to realizing the futuristic medical systemthat can serve the needed function at the right time and the right place withminimal invasiveness. Furthermore, nanodevices are expected to become an
important interface between basic biomedical science and clinical medicine byfacilitating the translation of basic achievements into clinical applications. Our
division wishes to produce revolutionary medical nano-devices based on
nanotechnology and thereby to spread the idea of “Nanomedicine”
intranationally and internationally.
Development of nano-scaled carriers of drugs and genes based on polymeric
micelles◦ Functional diagnostic imaging◦ Pinpoint cancer therapy◦ Gene therapy●
Development of functional polymeric micelles responsive to external stimuli● Development of functional cell arrays based on nano-fabrication of polymers● Development of intelligent scaffolds delivering drugs and genes and their application to regenerative medicine●

Environmental Health Sciences

http://env-health.m.u-tokyo.ac.jp/english/index.html

Children's health problems of today include such conditions as
disorders in the reproductive and immune functions, learning deficits,
mental problem and metabolic syndrome. Our research is carried out
on the recognition that the homeostasis is disrupted by various
environmentally hazardous chemicals, to which expectant mothers
and their newborn babies are exposed during their highly sensitive
period of life, and that the contamination with these chemicals maylead to various disease conditions in children after birth. Our
experimental investigations are focused on the following themes.
Elucidation of mechanisms involved in the manifestation of toxicity at
the molecular and cellular level due to exposure to environmental
pollutants, such as dioxin/PCBs and heavy metals.
● Clarification of epigenetic mechanisms that alter susceptibility to environmental chemicals.
● Development of methodologies for evaluating the toxicity of chemicals to the learning and emotion of rodents and of in vitro
toxicity techniques at the molecular and cellular levels.
● Development and application of techniques and methodology for evaluating risks of toxic substances in formulating safety
standard for the environment and food.
●52

Animal Resources / Research Resources and Support - Animal Research
Our laboratory focuses on understanding the molecular mechanisms
which underlie the synaptic plasticity, activity dependent formationof neuronal circuitry, and learning and memory. We generateknockout mice and inducible knockout mice of signal transduction
molecules including the glutamate receptors. We also manage theanimal facilities, give researchers advice on their animal
experiments, and give lectures on laboratory animal science so thatanimal experiments are carried out in consideration of animal
welfare.
Molecular analysis of brain function using genetically modified mice
Development of new reproductive technologies in mammals● Development of model animals for signal transduction diseases●●

A mutant mouse lacking metabotropic glutamate receptor
subtype-1 (mGluR1).

Molecular Radiology / Reserch Resources and Suport-Radiation Biology

http://www.cdbim.m.u-tokyo.ac.jp/
english/index.html

We are investigating the molecular mechanisms of DNA double-strand
break repair as the scientific basis of radiation therapy and chemotherapy
in medical oncology. We also promote the basic research that contributes
to the development of a novel therapeutic strategy by examining a link of
the DNA metabolic network including DNA replication and cell cycle
control with chromosome instability.
Molecular mechanisms of homologous recombinational repair
Mechanisms of the choice between homologous recombination andnon-homologous end-joining● Molecular mechanisms of DNA rereplication● Mechanisms of the genesis of aneuploidy● Functional analysis of meiotic recombination genes●●

Centrosome fragmentation which may lead to aneuploidy

Research Resources and Support-Bioinformatics

http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

Targeting biomedical research support using information technologies,
the division performs management of the research network and thecentral servers of the Graduate School of Medicine, and researches onknowledge infrastructure and processing techniques (e.g. information
model, ontology, natural language processing, machine reasoning, etc.)
and their application to clinical practice.
Biomedical research support using network system
Medical terminologies and ontologies● Standardization of healthcare information and information models● Natural language processing and its application to the medical domain● Machine reasoning and clinical decision support systems●●

Computer System for Biomedical Research

53

Institution

The Office of International Academic Affairs

http://koryu.m.u-tokyo.ac.jp/homepage10.html

The Office of International Academic Affairs is under the direct authority of the
Dean of the Graduate School of Medicine. Its four most important roles, as
defined by the Committee on International Academic Affairs, are i) international
educational exchange, ii) international contacts in research and scientific fields,iii) helping young researchers excel not only as scientists, but also as educators
for the next generation and as administrators of their research groups, and iv)
holding Medical English classes and developing language-teaching materials
for medical students.

Medical Library
The University of Tokyo Medical Library was opened in 1961 as a model of theJapanese modern medical library. The view makes it a perfect place toconcentrate on study.
The library has adopted an open stack system so that users can have directaccess to almost all the materials.
Holdings:
Books(number of volumes) : 280,578 (Japanese 111,986 Foreign 168,592)
Periodicals(number of titles) : 5,650 (Japanese 3,295 Foreign 2,355)● Visitors: 73,994● Borrowed Books: 11,514●54

http://www.lib.m.u-tokyo.ac.jp

Medical Scientist Training Program

http://www.ut-mdres.umin.jp/

Medical Scientist Training Program was launched in 2008, aiming that medical
students have the opportunity to experience basic medical research in theirearly years and learn the attitude as a researcher. Students taking thisprogram will attend activities such as journal club, medical English course, anassignment to the lab, and FQ, during their free time in addition to their usual
curriculum. Students are also expected to build up a network among medical
students who intend to be a researcher through the program support, such as
the short term stay at labs abroad, participations to the symposium, and theexcursion with other universities.

Museum of Health and Medicine
Museum of Health and Medicine was planned as part ofcommemorative projects to celebrate the 150th anniversaryof the founding of the School and the University of Tokyo
Hospital, and was opened on January 20, 2011. The firstpermanent exhibition was a display of medical texts andinstruments from the early Meiji era, Ishihara’s Color Blind
Test Charts and a gastroscope developed at the University.
Special exhibitions are planned to promote understanding
among the public regarding advances in medicine and healthcare. The first special exhibition is related to the beginningsof the School and the Hospital, entitled “the Challenge to
Infectious Diseases”. It introduced the history of vaccinations
against smallpox, research into infectious diseases
conducted in the University and its graduates since the Meiji
era (1868-1912), and the latest information about infectious
diseases and our current efforts. We will hold three special
exhibitions every year and events for our visitors.

55

Center

The International Research Center for Medical Education

http://www.ircme.u-tokyo.ac.jp/

The International Research Center for Medical Education is a research
institute to develop and improve medical education (including other
health professional education) domestically and internationally. We
implement innovative curricula for the Faculty of Medicine and invite
overseas experts to provide updated information about medical
education. We also manage international cooperation projects andproduce a research hub in medical education field in Asian region such
as Afghanistan and Lao P. D. R.

PBL class in Kabul Medical University, Afghanistan

56

Nurce Dormitory

East ClinicalResearch Bldg

ClinicalResearchCenterInpatients' Ward B

ClinicalAmphiteater

Inpatients'
Ward ARI Bldg.

Central Clinical

Hospital Service Bldg.
First
Research
Bldg.

New Central
Clinical Service Bldg.

Administration &Research Bldg.
Outpatient
Clinical Bldg.

Facility Center
Bldg.
No.4
South ClinicalResearch Bldg

MedicalLibrary
International
ResearchCenter for
Medical
Education
International
ResearchCenterBldg. No.2

Center for Disease
Biology andIntegrative
Medicine
Bldg.
No.3
Experimental Research Bldg.
Bldg. No.1

Bldg.
No.5

Annex of
Bldg.
No.3

Kohei Miyazono
Dean, Faculty of Medicine, Graduate School of Medicine
The University of Tokyo
Address:7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
http://www.m.u-tokyo.ac.jp

Issued on Sept. 10, 2011