75

他誌掲載論文

記録 3

Circulation Journal，

循環器内科

2 0 2 2 Mar 1 7 . doi：1 0 .1 2 5 3 /circj.CJ︲2 1 ︲Does pulmonary vein isolation prolong QT

1 08 3 .

interval?
Chikata A，Kato T，Usuda K，Hayashi K，One-year outcome after percutaneous coronary

Takamura Mintervention in nonagenarians: Insights from the（ Department of Cardiology, Toyama Prefectural

J-PCI OUTCOME registry

Central Hospital, Toyama, Japan. ）Otowa K，Kohsaka S，Sawano M，Matsuura S，Europace，2 02 1；2 3：2 04 6

Chikata A，Maruyama M，Usuda K，Watanabe T，Ishii H，Amano T，Nakamura M，Ikari Y

Cardiac thrombus grow th without D - dimer（ Department of Cardiology, Toyama Prefecturalelevation in atrial fibrillation-mediatedCentral Hospital, Toyama, Japan. ）cardiomyopathy

American Heart Journal，Chikata A，Kato T，Usuda K，Hayashi K，2 0 2 2 Apr;2 4 6：1 0 5 ︲1 1 6 . doi：1 0 .1 0 1 6 /Takamura M

j.ahj.2 02 2 .0 1 .0 04 . Epub 2 02 2 Jan 1 0 .

（ Department of Cardiology, Toyama Prefectural
Central Hospital, Toyama, Japan. ）Successful revascularization with percutaneous

J Interv Card Electrophysiol，

coronary intervention using a combination of the2 0 2 1；doi：1 0 .1 0 0 7 /s1 0 8 4 0 ︲0 2 1 ︲0 1 0 4 2 ︲subintimal transcatheter withdrawal technique

7 . Epub ahead of print

and coronary artery fenestration for spontaneous
coronary artery dissection

Precaval bundle re-entry atrial tachycardia: a

Shintaro Matsuura，Kanichi Otowa，variant of upper loop re-entry

Michiro Maruyama，Kazuo Usuda

Chikata A，Kato T，Usuda K，Hayashi K，（ Department of Cardiology, Toyama Prefectural

Takamura M

Central Hospital, Toyama, Japan. ）（ Department of Cardiology, Toyama Prefectural

Clinical Case Reports，2 02 1；9：e0 50 45

Central Hospital, Toyama, Japan. ）J Interv Card Electrophysiol，The combination of the STRAW technique and coronary

2 0 2 2；doi：1 0 .1 0 0 7 /s1 0 8 4 0 ︲0 2 1 ︲0 1 1 0 5 ︲artery fenestration using a cutting balloon could be

9 . Epub ahead of print.

effective in SCAD patients, especially with dissection to
the distal end of the coronary artery.

Rapidly Progressive Infected Coronary Artery
Aneurysm

血液内科

K Otowa，A Chikata，M Maruyama，K Usuda

Coombs ’ test positive autoimmune hemolytic（ Department of Cardiology, Toyama Prefectural

anemia accompanied by myelodysplastic

Central Hospital, Toyama, Japan. ）syndrome that became Coombs ’test negative：
Circulation Journal，2 0 2 1 Nov 2 5；8 5（ 1 2 ）after azacitidine administration．

2 24 6 .

Yamada S，Kajikawa S，Nakagawa N，Kondo Y，
Okumura H

Multiple Spontaneous Coronary Artery：9 1 5 ︲Ann Hematol，2 0 2 2 Apr；1 0 1（ 4 ）Dissections and Ruptures in Vascular Ehlers-

9 17

Danlos Syndrome
Fukuhara K，Otowa K，Chikata A，Maruyama M，Imaging findings of a case of intravascular large

Usuda K

B-cell lymphoma with cardiac involvement.

（ Department of Cardiology, Toyama Prefectural

Kadoya Y，Nagaoka S，Kanatani M，Nagaoka R，Central Hospital, Toyama, Japan. ）Maekawa N，Terada N，Nakagawa N，Kajikawa S，

他誌掲載論文

76

Okumura H，Ishizawa S

observed, and the patient required temporary drug

：1 78 0 ︲Radiol Case Rep，2 02 1 May 4；1 6（ 7 ）inter r uption; however, we were able to continue

1 78 4entrectinib following a short-term drug interruption. Thisis the first report on the effectiveness of entrectinib

呼吸器内科

against lung adenocarcinoma with the rare MYH9 -ROS1

Bochdalek hernia with liver herniation

fusion gene.

Mao Kanatani，Hirokazu Taniguchi，Kimiho Kusabiraki，Yasuaki Masaki，A phase II study of S-1 and cisplatin withTakeshi Tsuda，Hitoshi Abo

concurrent thoracic radiotherapy followed byClin Case Rep，2 02 2；1 0：e0 55 34

durvalumab for unresectable, locally advanced
non-small-cell lung cancer in Japan (SAMURAI

Bochdalek hernia with liver herniation is rare andstudy)

mimics a pulmonary mass. This case was hospitalized for

Shigeru Tanzawa，Sunao Ushijima，masses found in the lower field of the right lung on a chest

Kazuhiko Shibata，Takuo Shibayama，radiograph. The patient was diagnosed with Bochdalek

Akihiro Bessho，Kyoichi Kaira，

hernia with liver herniation with three-dimensional images

Toshihiro Misumi，Kenshiro Shiraishi，created from thoraco-abdominal enhanced computed

Noriyuki Matsutani，Hisashi Tanaka，

tomography.

Megumi Inaba, Terunobu Haruyama，Junya Nakamura，Takayuki Kishikawa，Rare MYH9 -ROS1 Fusion Gene-Positive Lung

Masanao Nakashima，Keiichi Iwasa，

Adenocarcinoma Showing Response to

Keiichi Fujiwara，Tadashi Kohyama，Entrectinib Treatment:A Case Study

Shoichi Kuyama，Naoki Miyazawa，Takeshi Tsuda，Naoki Takata，Takahiro Hirai，Tomomi Nakamura，Hiroshi Miyawaki，Yasuaki Masaki，Shin Ishizawa，Hiroo Ishida，Naohiro Oda，

Hirokazu Taniguchi

Nobuhisa Ishikawa，Ryotaro Morinaga，Case Rep Oncol，2 02 2；1 5：3 76 ︲3 81

Kei Kusaka，Nobukazu Fujimoto，
Toshihide Yokoyama，Kenichi Gemba，

The c-ros oncogene 1 (ROS1 ) fusion gene is a rare

Takeshi Tsuda，Hideyuki Nakagawa，

genomic alteration detected in nearly 1 –2 % of lung

Hirotaka Ono，Tetsuo Shimizu，adenocarcinomas. The major partner genes of ROS1

Morio Nakamura，Sojiro Kusumoto，

include CD7 4 , SDC4 , and EZR. Here, we report a case of

Ryuji Hayashi，Hiroki Shirasaki，

MYH9 -ROS1 fusion gene-positive lung adenocarcinoma, aNobuaki Ochi，Keisuke Aoe，rare ROS1 fusion gene. The patient was a woman in her

Nobuhiro Kanaji，Kosuke Kashiwabara，

4 0 s who was diagnosed with advanced primary lung

Hiroshi Inoue，Nobuhiko Seki

adenocarcinoma after a thorough examination. Initial

Ther Adv Med Oncol ，genetic testing conducted using mediastinal lymph node

2 02 1 Feb 2 7；1 3：1 75 88 3 59 2 19 9 85 88 .

biopsy specimens collected by endobronchial ultrasoundguided transbronchial needle aspiration revealed no driver

Background: Based on the results of the PACIFIC study,

gene mutations, including the ROS1 fusion gene. The

chemoradiotherapy followed by 1 -year consolidation

patient was treated with four courses oftherapy with durvalumab was established as the standard

immunochemotherapy. As the disease worsened, anotherof care for unresectable, locally advanced non-small-cell®

genetic test was conducted using FoundationOne CDx,lung cancer (LA︲NSCLC). However, some topics notand the MYH9 -ROS1 fusion gene was detected. Multiple

foreseen in that design can be explored, including

lung metastases disappeared after the administration ofprogression-free survival (PFS) and overall survival (OS)entrectinib; the response persisted up to a year. Adverse

after the start of chemoradiotherapy, the proportion of

events of rash, dysgeusia, and peripheral edema were

patients who proceeded to consolidation therapy with

77

他誌掲載論文durvalumab, and the optimal chemotherapeutic regimens.

Long-term outcomes after endoscopic retrograde

In Japan, the combination regimen of S-1 + cisplatin (SP),pancreatic drainage for symptomatic

for which the results of multiple clinical studies havepancreaticojejunal anastomotic stenosis

suggested a good balance of efficacy and tolerability, is

Akihiko Kida 1，Yukihiro Shirota 2，Taro Kawane 3，

frequently selected in clinical settings. However, theHitoshi Omura 3，Tatsuo Kumai 2，Masaaki Yano 3，

efficacy and safety of consolidation therapy with

Fumitaka Arihara 3，Yuji Hodo 2，

durvalumab following this SP regimen have not been

Koichiro Matsuda 3，Kohei Ogawa 3，

e v a l u a t e d . We t h e re f o re p l a n n e d a m u l t i c e n t e r,

Mitsuru Matsuda 3，Akito Sakai 3，

prospective, single-arm, phase II study.

Mitsuhiro Terada 1，Tokio Wakabayashi 2

Methods: In treatment-naïve LA-NSCLC, two cycles of（ 1 Department of Gastroenterology，JA Toyama

combination chemotherapy with S-1 (8 0 -1 2 0 mg/body,

Kouseiren Takaoka Hospital,

Days 1 -1 4 ) + cisplatin (6 0 mg/m2 , Day 1 ) will be

2

Department of Gastroenterology, Saiseikaiadministered at an interval of 4 weeks, with concurrent

Kanazawa Hospital, .

thoracic radiotherapy (6 0 Gy). Responders will then3

receive durvalumab every 2 weeks for up to 1 year. The

Prefectural Central Hospital

primary endpoint is 1 -year PFS rate.

4

Discussion: Compared with the conventional standard

Kouseiren Takaoka Hospital ）Department of Internal Medicine, Toyama
Department of Gastroenterology, JA Toyama

regimen in Japan, the SP regimen is expected to be
associated with lower incidences of pneumonitis,

There is limited evidence supporting the usefulness ofesophagitis, and febrile neutropenia, which complicate theendoscopic retrograde pancreatic drainage (ERPD) for

initiation of consolidation therapy with durvalumab, andsymptomatic pancreaticojejunal anastomotic stenosis

have higher antitumor efficacy during chemoradiotherapy.

(sPJS). We examined the usefulness of ERPD for sPJS. We

Therefore, SP-based chemoradiotherapy is expected to be

conducted a retrospective analysis of 1 0 benign sPJS

successfully followed by consolidation therapy withpatients. A forward-viewing endoscope was used in all

durvalumab in more patients, resulting in prolonged PFS

sessions. Following items were evaluated: technicaland OS. Toxicity and efficacy results of the SP regimen insuccess, adverse events, and clinical outcome of ERPD.

this study will also provide information important to the

The technical success rate was 1 0 0 % (1 0 /1 0 ) in initial

future establishment of the concurrent combination of

ERPD; 9 patients had a pancreatic stent (no-internal-flap: nchemoradiotherapy and durvalumab.

= 4 , internal-flap: n = 5 ). The median follow-up was 9 20
days. Four patients developed recurrence. Among them, 3

消化器内科

had a stent with no-internal-flap in initial ERPD, the stent

EUS-FNA で診断し得た膵放線菌症の 1 例

migrated in 3 at recurrence, and a stent was not placed in

林 洸太郎，川根太郎，伊藤 綾，矢野正明，

1 patient in initial ERPD. Four follow-up interventions

在原文教，松田耕一郎，小川浩平，松田 充，

were performed. No recurrence was observed in 6

酒井 明人

patients. None of the stents migrated (no-internal-flap: n =日本消化器病学会雑誌，2 0 2 1；1 1 8 巻 9 号：

1 , internal-flap: n = 5 ) and no stents were replaced due to

8 84 ︲8 89 .

stent failure. Stenting with no-internal-flap was associatedwith recurrence (p = 0 .0 4 2 ). Mild adverse events

症例は 6 0 歳男性．アルコール性慢性膵炎にて膵管ステ

developed in 1 4 .3 % (2 /1 4 ). In conclusions, ERPD was

ントの交換を繰り返していた．2 0 1 X︲1 年 1 2 月の画像検

performed safely with high technical success. Recurrence

査で膵頭部腫瘤の指摘があったが，膵炎の慢性経過と考え

was common after stenting with no-internal-flap. Long-

られ，慎重経過観察の方針となった．2 0 1 X 年 3 月の画像

term stenting did not result in stent failure.Clinical trial

検査では膵頭部腫瘤の腫大を認め，精査目的に EUS︲FNA

register and their clinical registration number：Nos. 5 8 ︲を施行した．病理では豊富な間質組織放線菌を主とした細1 15 and R2 ︲9 .

菌塊を認めた．半年間の抗菌薬加療で膵頭部腫瘤の縮小を認めた．

Long-term outcoBipolar-current needle-knife

他誌掲載論文78

with a water jet function (Jet B-knife) shortens

were not statistically significant between the two groups.

the procedure time of endoscopic submucosal

Conclusions: Use of the Jet B-knife may contribute to thedissection for colorectal tumors

development of a time-saving, cost-effective, and safe

11

Katsushi Hiramatsu ，Tatsushi Naito ，1

1

procedure for ESD of colorectal tumors.
1

Yu Akazawa ，Yasushi Saito ，Takuto Nosaka ，Kazuto Takahashi 1，Kazuya Ofuji 1，
1

感染症内科
1

Hidetaka Matsuda ，Masahiro Ohtani ，22

Mitsuru Matsuda ，Akito Sakai ，Yasunari Nakamoto1

Duration from onset to discharge is longer in
COVID-1 9 patients with low blood regulatory
T-cell counts

1

Hiroyasu Kaya1，Daisuke Usuda2（ Second Department of Internal Medicine,
Faculty of Medical Sciences, University of Fukui,

1

2

Hospital, Toyama, Japan

Toyama Prefectural Central Hospital ）2

COVID-1 9 Team, Toyama Prefectural Central
Department of Emergency and Critical Care

Background: Endoscopic submucosal dissection (ESD) is

Medicine, Juntendo University Nerima Hospital,

a technically difficult and time-consuming procedure forTokyo, Japanthe treatment of large colorectal tumors. In Japan, the ball-

J Med virol，doi：org/1 0 .1 00 2 /jmv.2 74 01

tip bipolar-current needle-knife (BB-knife) has been usedin ESD as a safe device that minimizes the damage to

We read with interest the article by Rahimzadeh et al.

deeper tissues of colorectal neoplasms. In May 2 0 1 2 , a

They observed a trend toward decreasing regulatory T-cell

BB-knife combined with a water jet function (Jet B-knife)(T reg) levels in severe coronavirus disease 2 0 1 9

was newly developed.

(COVID-1 9 ) patients 1 . We also studied the relationship

Methods: This retrospective study was aimed at

between T reg in peripheral blood and severity of

examining the effectiveness and safety of the Jet B-knife.

COVID-1 9 , and believe that T reg is important in the

The BB-knife was used in 2 7 6 lesions (BB-knife group),

progression of COVID-1 9 cases from serious to very

while the Jet B-knife was used in 2 45 lesions (Jet B-knife

severe.

group). We evaluated tumor characteristics and the results

Severe COVID-1 9 patients show various immunologicalof the ESD procedures, including the size of the resected

abnormalities, including T-cell reduction and cytokine

tumor, histological diagnosis, time required for resection,

release syndrome. Previous reports have suggested afrequency of using other electrical devices, en bloc

correlation between abnormalities in T reg and theresection rate, and incidence rate of associatedautoimmune system 2 ,3 . Single cell-level mechanisms forcomplications. Then, the data obtained were compared

T-cell dysregulation in severe COVID-1 9 have alreadybetween the two groups.

been shown 4 .

Results: The histological evaluation of the resected

We performed a prospective observational study attumors revealed that the incidence of cancer was not

Toyama Prefectural Central Hospital, in Japan. The

significantly different between the two groups. The median

research participants included 2 9 patients with positive

time required for resection was 1 03 min (4 5 ︲2 55 ) in the

results for SARS-CoV-2 RNA (1 1 wild types, 1 7 alphaBB-knife group and 5 1 min (2 8 ︲2 1 0 ) in the Jet B-knife

variants, 1 delta variant) between 1 November 2 0 2 0 andgroup. The difference was statistically significant (p <3 0 July 2 02 1 . We chose the first 2 9 consecutive patients0 .0 5 ). Furthermore, the median tumor diameters werewith pneumonia at admission. The primary outcome was

2 3 .1 mm (1 8 ︲5 0 ) and 2 6 .2 mm (2 0 ︲6 0 ) in the BB-knife

the duration in days from onset to discharge. Typically,and Jet B-knife groups, respectively, demonstrating apatients were discharged approximately 1 0 days fromstatistically significant difference (p < 0 .0 5 ). Multivariate

onset and 3 days from improvement of fever or respiratory

logistic regression analysis revealed that short resection

symptoms by rule, although hospitalization was prolonged

time (p < 0 .001 ) and reduced use of hemostatic devices (pon a case-by-case basis. We collected the following< 0 .0 1 ) were independent favorable features of Jet

baseline, demographic, clinical, laboratory characteristics,

B-knife. The en bloc resection rate and the perforation rate

treatment and outcome data: age, sex, peripheral T reg

79

他誌掲載論文counts (CD4 -positive, CD2 5 -positive and CD1 2 7 -only two days between the period of hospitalization

negative cells) by flow cytometry (BML, Inc., Tokyo,

between the two groups might be related to the significant

5Japan) on admission , complications of pneumonia, and use

response to steroids in severe cases. Methods to repair Tof oxygen therapy. The cut-off value for the T reg countreg activity might, thus, help improve the severity of

was determined by receiver operating characteristic (ROC)

COVID-1 9 . We hope that the updated data will contributecurve analysis. We applied univariate and multivariate

to more accurate elaboration and substantiation of theanalysis to compare each of the characteristics andfindings reported by Rahimzadeh et al.

outcome data. Patients were allocated into two groups on
the basis of the following cut-off values: Group A, patients

リウマチ・和漢診療科

with low T reg levels (<1 3 / μ L) and pneumonia; Group

Effectiveness and safety of subcutaneous

1 3 / μ L) andabatacept in biologic-naïve RA patients at Week

pneumonia. Comparison of the two groups for duration

5 2 : A Japanese multicentre investigational study

from onset to discharge was performed using the Kaplan-(ORIGAMI study).

B, patients with high T reg level (Meier method for comparison of disease severity. EZR

Naoto Tamura 1，Takanori Azuma 2，

version 1 .5 4 was used for all statistical analyses 6 .

Kenta Misaki 3，Rei Yamaguchi 4，First, the optimal cut-off for regulatory T-cell count was

Fuminori Hirano 5，Eiji Sugiyama 6，

determined as 1 3 / μ L by ROC curve analysis. The mean

Daisuke Kanai 7，Yohko Murakawa 8，

T reg count of patients with severe pneumonia (asMotohiro Oribe 9，Takahito Kimata 10，

determined by the need for oxygen therapy) and without

Kazutoshi Aoki 1 1，Tomoko Sugiura 1 2，

severe pneumonia were 1 8 .9 and 2 3 .3 , respectively. The

Koji Takasugi 1 3，Yuya Takakubo 1 4，

mean T reg count of patients with severe pneumonia

Yasuyuki Tomita 15，Takeo Isozaki 16，

tended to be lower, although the difference between the

Toshihiro Nanki 17，Naooki Katsuyama 1 8，

6 5 years, sex, variant

Takanori Kuroiwa 1 9，Hideto Oshikawa 2 0，type, and low T reg level (<1 3 / μ L) did not correlate

Motohide Kaneko 2 1，Hiroshi Fujinaga 2 2，

significantly with complications of severe pneumonia in

Kiwamu Saito 2 3，Eiichi Tanaka 4，

univariate analyses. These categories were therefore

Eisuke Inoue 4 2 4，Yuri Yoshizawa 2 5，

removed from this model on multivariate logistic

Shigeru Matsumoto 2 6，Hisashi Yamanaka 4 2 7，regression analysis. However, the T reg count of one

Masayoshi Harigai 4

patient with high blood T reg count on admission and(1 Department of Internal Medicine andsevere pneumonia decreased before intubation (from 3 3 /Rheumatology, Juntendo University, Tokyo,

μ L to 1 0 .8 / μ L). If more such cases are evaluated orJapan

the timing of T reg examination is changed, we might find

2

Azuma Rheumatology Clinic, Saitama, Japana significant correlation between low T reg level and3

Department of Rheumatology, Kita-Harimagroups was not significant. Agecomplications of severe pneumonia. Furthermore, theMedical Center, Hyogo, Japan

onset to discharge duration in Group A was significantly

4longer in comparison with Group B (Figure 1 ). The medianInternal Medicine, Tokyo Women ’s Medical

duration in COVID-1 9 patients with pneumonia and low T

University School of Medicine, Tokyo, Japanreg count was 1 9 days, while that in COVID-1 9 patients5with pneumonia and high T reg count was 1 7 days.

Medical Center, Hokkaido, Japan

Our data suggested that peripheral blood T reg levels on
admission are associated with severe pneumonia requiring

6

Division of Rheumatology, Department of

Department of Rheumatology, NHO Asahikawa
Department of Clinical Immunology andRheumatology, Hiroshima University Hospital,

oxygen therapy, but not with pneumonia without oxygen

Hiroshima, Japan

therapy. The difference in median days from onset to7discharge between pneumonia patients with low T reg andKyousai Hospital, Kanagawa, Japanhigh T reg counts was suggested to indicate the difference

8in the strength of the immune response. The difference ofUniversity Hospital, Shimane, Japan

Department of Nephrology, Yokohama Minami
Department of Rheumatology, Shimane

他誌掲載論文
980

Department of Rheumatology, Oribe

subcutaneously once a week. Clinical outcomes included

Rheumachika Naika Clinic, Oita, Japan

Simplified Disease Activity Index (SDAI) remission at

10

Week 5 2 (primary endpoint), Japanese Health Assessment

Department of Rheumatology, Bayside Misato

Medical Center, Kochi, Japan

Questionnaire (J-HAQ), EuroQol 5 -Dimension

11

Aoki Medical Clinic, Saitama, Japan

Questionnaire (EQ-5 D), treatment retention, and safety.

12

Department of Rheumatology, Sugiura Clinic,

The results were compared with those of conventional

Shimane, Japans yn th etic dis ea s e- modif yin g a n ti rh eu ma ti c dr u g

13(csDMARD) controls from the ongoing Institute of

Department of Internal Medicine, Kurashiki

Sweet Hospital, Okayama, Japan

Rheumatology, Rheumatoid Arthritis (IORRA) registry.

14

Results: Overall, 325 patients were enrolled, with a mean

Department of Rehabilitation Surgery, Yamagata

University Hospital, Yamagata, Japanage of 6 6 .9 ± 1 2 .7 years. The proportion of patients

15

achieving SDAI remission（ ≤ 3 .3 ）at Week 5 2 was

Department of Rheumatology, Tomita Medical

Clinic, Chiba, Japan
16

Division of Rheumatology, Department of

1 8 .9 ％（ 9 5 ％ CI: 1 4 .3 ︲2 3 .6 ）and low disease activity（ ≤ 11 ）was 53 .3 ％（ 95 ％ CI: 47 .4 ︲59 .1 ）．A significant

Medicine, Showa University, Tokyo, Japan

improvement was observed in J︲HAQ and EQ︲5 D over

17

Division of Rheumatology, Department of

5 2 weeks in both the abatacept and csDMARD groups.

Internal Medicine, Toho University School of

The probability of abatacept treatment retention at Week

Medicine, Tokyo, Japan

52 was 69 .9 ％（ 95 ％ CI: 64 .7 ︲75 .5 ）．Adverse events

18

Setagaya Rheumatology Clinic, Tokyo, Japanand serious adverse events were reported in 5 0 .0 ％ and19

Department of Internal Medicine, Yukioka

1 2 .1 ％ of patients, respectively.

Hospital, Osaka, Japan

Conclusions: Abatacept significantly improved disease20

activity, physical disability, and quality of life for up to

Department of Rheumatology, Japanese Red

Cross Kumamoto Hospital, Kumamoto, Japan
21

Kaneko Clinic, Saitama, Japan

22

Department of Rheumatology and Japanese

5 2 weeks in RA patients in a real-world setting.
小児科

Oriental Medicine, Toyama Prefectural Central

出生直後より遷延する喘鳴から診断に至った肺動脈スリン

Hospital, Toyama, Japan

グの新生児例

23

Department of Orthopedics, Nagoya Kyukeikai

竹中みか，藤田修平，西田圭吾，齊藤 悠，

Saito Clinic Orthopedics & Rheumatology, Aichi,

高桑麻衣子，嶋尾綾子，伊奈志帆美，東山弘幸，

Japan

二谷 武，五十嵐登，畑崎喜芳

24Showa University Research Administration

Center, Showa University, Tokyo, Japan25（ 富山県立中央病院 小児科）
富山県立中央病院医学雑誌，2 02 1；4 4：2 5 ︲2 8

Department of Immunology Medical, Bristol-

Myers Squibb K.K, Tokyo, Japan

Catheter ablation in a pediatric patient with26

idiopathic ventricular tachycardia andMedical Affairs, Ono Pharmaceutical Co., Ltd,

Osaka, Japan
27

Department of Rheumatology, Sanno Medical

arrhythmia-induced cardiomyopathy.
Shuhei Fujita，Keigo Nishida，Akio Chikata，Center, Tokyo, Japan ）Kazuo Usuda，Kiyoshi Hatasaki

Modern Rheumatology，2 02 1 Oct 8；1 ︲1

Pediatr Int，2 02 1；6 3：7 16 ︲7 38

Objectives: To evaluate the effectiveness and safety ofSuperior slow pathway を介した Fast-slow 房室結節abatacept over 5 2 weeks in biologic-naïve rheumatoid

リエントリー性頻拍に対して無冠尖からの通電で完治した

arthritis (RA) patients with moderate disease activity in

11 歳男児例

the prospective, 5 -year, observational study (ORIGAMI

藤田修平，中川 亮，水冨慎一朗，畑崎喜芳，

study) in Japan.

近田明男，臼田和生

Metho ds: Abatacept (1 2 5 mg) was administered

臨床心臓電気生理，2 02 1；4 4：9 9 ︲1 08

81

他誌掲載論文The efficacy of pacemaker implantation for

significantly between the groups with a history of otherextracardiac total cavopulmonary connection in a

primary malignancies [HoM(+)] and without a history ofpediatric patient with bradycardia-tachycardia

other primar y malignancies [HoM(-)]. Incidental

syndrome.

indications during malignancy follow-up was the most

Shuhei Fujita，Eriko Kabata，Keigo Nishida，common reason for the diagnosis of PDAC in the HoM(+)

Noboru Igarashi，Akira Murata，Kiyoshi Hatasakigroup. Conversely, there were no significant differences in

November 2 2，2 02 1；

the resectability (P=0 .6 4 5 ), complete resection rate

doi:https://doi.org/1 0 .1 0 1 6 /j.jccase.

(P=0 .7 7 4 ) and final stage (P=0 .4 7 4 ) between the two

2 02 1 .1 0 .0 08

groups. Disease-free survival was also not significantly
different between the two groups (P=0 .1 8 4 ). However,

傍膜様部心室中隔欠損症の生後 1 か月時点での標準 12 誘

overall survival was significantly poorer in the HoM(+)

導心電図による予後予測

group compared with the HoM(-) group (P=0 .0 0 3 ). A

中川 亮，藤田修平，佐藤 啓，畑崎喜芳

history of other primary malignancies was also an

Pediatric Cardiology and Cardiac Surgery，

independent predictor of poor overall survival (hazard

2 00 1；3 7（ 3 ）：2 03 ︲2 07

ratio, 2 .4 1 6 ; 9 5 % confidence interval, 1 .3 2 4 -4 .4 0 6 ;P=0 .0 0 4 ). In conclusion, patients with PDAC and a外科history of other primary malignancies had significantly

Clinical features of patients with pancreaticpoorer overall survival than their counterparts, despite no

ductal adenocarcinoma with a history of other

differences in disease-free survival.

primary malignancies: A retrospective analysis
Hironori Hayashi 1，Koji Amaya 1，
1

Thoracoscopic esophagectomy in the prone

1

Tomokazu Tokoro ，Kosuke Mori ，1

Shunsuke Takenaka ，Yuya Sugimoto
1

position for esophageal cancer patients with1

1

Yuto Kitno ，Toru Kurata ，Tomoya Tsukada, Yuto Kitano, Yuya Sugimoto,

1

1

1

1

Koichi Shimizu and Kiichi Maeda

1

Shunsuke Kawai ，Atsushi Hirose ，Tomoya Tsukada ，Masahide Kaji ，2

1（ Department of Surgery, Toyama Prefectural
Central Hospital, Toyama;

pectus excavatum: a report of two cases2

Masahide Kaji
（ Department of Surgery, Toyama Prefectural
Central Hospital ）Surgical case reports，2 02 1；7：1 13

Department ofSurgery, Kaga Medical Center, Kaga, Ishikawa,

Background: Pectus excavatum is a common thoracic

Japan ）

deformity that can be encountered during thoracoscopic

Molecular and Clinical Oncology，2 0 2 1；1 5：

esophagectomy. Here, we report two cases of esophageal

173

cancer complicated by pectus excavatum that were treatedwith thoracoscopic esophagectomy with the patients in thePatients with pancreatic ductal adenocarcinoma (PDAC)

prone position.

that have a history of other primary malignancies are not

Case presentation: The first patient was a 6 4 -year-old

well documented. The current study therefore aimed tomale diagnosed with esophageal cancer (cT3 N0 M0 ,evaluate the clinicopathological characteristics of patientsHaller index 8 .5 ) and underwent radical thoracoscopic

with PDAC with or without a history of other primaryesophagectomy in the prone position following neoadjuvant

malignancies. A total of 1 0 2 patients with surgicallychemotherapy. The second patient was a 6 7 -year-old maletreated PDAC that presented with or without a history of

diagnosed with esophageal cancer (cT1 bN0 M0 , Haller

other primary malignancies were retrospectively analyzed.

index 4 .3 ), and the same procedure was performed in thisA total of 2 5 patients (2 4 .5 %) had a history of other

patient. In cases of patients with a high Haller index,

primary malignancies (age, with history of other primary

where securing the surgical field is difficult, preoperative

malignancy vs. without, 7 4 .2 vs. 6 8 .9 years; P=0 .0 0 5 )computed tomography in the prone position can help

and the reason for consultation (P<0 .0 0 1 ) differed

surgeons to understand the mediastinal field of view and is他誌掲載論文

82

safe.

Facet joint violation by thoracolumbar

Conclusions: Radical thoracoscopic esophagectomy in thepercutaneous pedicle screw and its effect onprone position may be a surgical option in patients with

progression of facet joint osteoarthritis

pectus excavatum.

Sasagawa T
Asian Spine Journal，2 02 1 Sep 2 8；
doi: 1 0 .3 16 16 /asj.2 02 1 .0 22 4 .

整形外科
Postoperative blood loss including hidden blood
loss in early and late surgery using percutaneous

Utility of the energy subtraction method for

pedicle screws for traumatic thoracolumbar

thoracic spine radiography in clinical practice:fracture

An analysis of 2 5 patients with multiple

Sasagawa T，Takeuchi Y，Aita I

myeloma.

Spine Surgery and Related Research，

Shimizu T，Sasagawa T，Kawamura N，

2 02 1；5：1 71 ︲1 75

Masuyama S，Tachibana N，Emori H，Iizuka M，Ishikura H，Suzuki K, Kuwabara T，Tsuchiya H，

Minimally invasive surgery for traumatic highKunogi J

grade lateral spondylolisthesis of L1 with multiple

Orthopedics，2 02 1；4 4：e3 1 ︲e3 5

spinal fractures: closed reduction and internal
fixation using percutaneous pedicle screws

Conjoined tendon preserving posterior

Sasagawa T

approach in hemiarthroplasty for femoral neck

Asian Journal of Neurosurgery，

fractures: A prospective multicenter clinical

2 02 1；1 6：6 92 ︲6 94

study of 3 2 2 patients.
Takuya Nakamura, Yamakawa T, Hori J,

Patient satisfaction with implant removal after

Goto H, Nakagawa A, Takatsu T, Osamura N,

stabilization using percutaneous pedicle screws

Saito A, Hagio K, Mouri K

for traumatic thoracolumbar fracture

Journal of Orthopaedic Surgery，2 0 2 1；2 9：
1 ︲8

Sasagawa T，Takagi Y，Hayashi H，Nanpo K
Asian Journal of Neurosurgery，
2 02 1；1 6：6 92 ︲6 94「 低侵襲 THA の手術手技と今後の展望」序文
中村琢哉，兼氏 歩Treatment of unstable pelvic ring injury with a

日本整形外科学会雑誌 Vol.9 6，2 0 2 2；No.4：

dual internal anterior

2 21 ︲2 22

subcutaneous fixator

using spinal instrumentation called “ dual
INFIX ”: a case report

呼吸器外科

Sasagawa T

A case of giant intradiaphragmatic bronchogenic

Journal of Orthopaedic Case Reports，

cyst

2 02 1；1 1：3 3 ︲3 6

Naoya Kitamura，Tomohiko Takahashi，Tetsuya Takayama，Jun Kawamukai，Treatment of unstable sacral fracture with

Hideki Shinno，Hideki Miyazawa

minimally invasive spinopelvic posterior fixation（ Toyama Prefectural Central Hospital thracic

and an internal anterior fixator in a 9 5 -year-

surgery ）old patient with diffuse idiopathic skeletal

Respirology Case Reports，2 02 1；9：e0 83 2

hyperostosis: A case report
Sasagawa T

産婦人科

Journal of Orthopaedic Case Reports，Fascia の構造と変化から謎を解く

2 02 1；1 1：4 3 ︲4 6

谷村 悟
（ 富山県立中央病院 産婦人科）

83

他誌掲載論文
産科と婦人科，2021；88：1033 ︲1039

飴谷由佳，谷村 悟（ 富山県立中央病院 産婦人科）

Fascia（ ファシア）が柔軟にかつ連携をもって支え，機富山県立中央病院医学雑誌，2 0 2 2 . 0 3；4 5 巻

能させる

1 ︲2 号：2 1 ︲2 4

谷村 悟
（ 富山県立中央病院 産婦人科）

予防的卵巣卵管切除施行し，漿液性卵管上皮内癌を認めた

排尿障害プラクティス，2 02 1；2 9：1 02 ︲1 06

遺伝性乳癌卵巣癌症候群（ HBOC）の一症例
川上翔子，南 里恵，草開 妙，中島正雄，
林 晃輝，八十島巌，碓井 愛，中垣成子，

女性医師のリクルート
草開 妙，谷村 悟

本多真澄，草開友理，吉越信一，炭谷崇義，（ 富山県立中央病院 産婦人科）

中島正雄，飴谷由佳，谷村 悟

産婦人科の実際，2 02 2；7 1 巻 3 号：2 57 ︲2 62（ 富山県立中央病院 産婦人科）
富山県立中央病院医学雑誌，2 0 2 2 . 0 3；4 5 巻
1 ︲2 号：3 2 ︲3 5

子宮全摘術後に CIN3 から扁平上皮癌に進行し治療後も腟
上品が胃腫瘍の再発を繰り返した 1 例
田中有華，南 里恵，曽根原健太，谷村 悟，

皮膚科

吉越信一，飴谷由佳【 皮膚悪性腫瘍（ 第 2 版 ）下－基礎と臨床の最新研究動（ 富山県立中央病院 産婦人科）

向－ 】乳房外パジェット病 治療 手術治療 切除マー

日本婦人科腫瘍学会雑誌，2 02 1 . 0 7；3 9 巻 3 号：

ジンと再建

6 19 ︲6 27

八田尚人（ 富山県立中央病院皮膚科）

日本臨床，2 02 1；7 9 増刊 3：2 77 ︲2 80

骨盤臓器脱に対する腹腔鏡下仙骨膣固定術（ Laparoscopic
Sacral Colpopexy:LSC) の代替術式としての腹腔鏡下ペクトペキシ－（ Laparoscipic Pectopexy:LP)【 皮膚悪性腫瘍 ( 第 2 版 ) 下－基礎と臨床の最新研究動中島雅子，谷村 悟，坂井英慧，道倉瑛里奈，

向－ 】基底細胞癌 基底細胞癌の治療 基底細胞癌の治

浅井隆之，本多真澄，草開友理，草開 妙，療戦略 概論吉越信一，炭谷崇義，中島正雄，南 里恵，

八田尚人

飴谷由佳

（ 富山県立中央病院（ 富山県立中央病院産婦人科）

日本臨床，2 02 1；7 9 増刊 3：2 24 ︲2 26

皮膚科）

富山県立中央病院医学雑誌，2 0 2 1 . 0 9；4 4 巻
3 ︲4 号：7 4 ︲7 8

手指に生じた腱鞘線維腫 結節性筋膜炎と鑑別を要した
1例

腹腔鏡下子宮体癌手術と有棘縫合糸を用いた Native

池田智行，八田尚人，石井貴之，石澤 伸，tissue repair を同時に施行した一例

齋藤 敦

中島雅子，谷村 悟，林 晃輝，八十島巌，

皮膚科の臨床，2 02 1；6 3：1 20 6 ︲1 20 8

碓井 愛，川上翔子，中垣成子，本多真澄，
草開友理，草開 妙，吉越信一，炭谷崇義，

上肢深部静脈血栓症 3 例の報告

中島正雄，南 里恵，飴谷由佳

池田智行，石井貴之，八田尚人（ 富山県立中央病院 産婦人科）（ 富山県立中央病院

富山県立中央病院医学雑誌，2 0 2 1 . 0 9；4 4 巻

皮膚科の臨床，2 02 1；6 3：1 11 1 ︲1 11 4皮膚科）

3 ︲4 号：7 0 ︲7 3【血管性腫瘍】先天性血管腫の 2 例
当院で経験した再生不良性貧血合併妊娠の 3 例

石井貴之，八田尚人

八十島巌，中島正雄，林 晃輝，碓井 愛，（ 富山県立中央病院

川上翔子，中垣成子，本多真澄，草開友理，

皮膚病診療，2 02 1；4 3：3 12 ︲3 15

草開 妙，吉越信一，炭谷崇義，南 里恵，

皮膚科）

他誌掲載論文
皮膚悪性腫瘍ガイドライン第 3 版 乳房外パジェット病
診療ガイドライン 20 2 1

84

Intravascular large B-cell lymphoma (IVLBCL) is a veryrare subtype of malignant lymphoma that is difficult to吉野公二（ がん・感染症センター都立駒込病院

diagnose. Cases of myocardial infarction caused by

皮膚腫瘍科），清原隆宏，逆瀬川純子，八田尚人，

IVLBCL are even rarer. Herein, we report a case

藤澤康弘，村田洋三，古賀弘志，菅谷 誠，公益presenting with heart failure and delayed enhancement in

社団法人日本皮膚科学会，一般社団法人日本皮膚the hypokinetic cardiac septum on contrast-enhanced

悪性腫瘍学会皮膚悪性腫瘍診療ガイドライン改訂

cardiac magnetic resonance imaging. Myocardial biopsy委員会（ 乳房外パジェット病診療ガイドライン

showed large B-cell lymphoma cells in the microvessels

グループ）

within the myocardium. To the best of our knowledge, this

日本皮膚科学会雑誌，2 02 1；1 31：2 25 ︲2 44is the first repor t of imaging findings of cardiac
involvement in IVLBCL.

皮膚科処置 基本の「キ」切除マージンの取り方
石井貴之

乳腺病変を合併した肺アミロイドーシスの 1 例（ 富山県立中央病院 皮膚科）

長岡将太郎 1，阿保 斉 1，角谷嘉亮 1，

Derma，2 02 1；3 11：8 ︲1 8

齊藤順子 1，望月健太郎 1，出町 洋 1，
川向 純 2，石澤 伸 3

眼科（ 1 富山県立中央病院 放射線診断科，2 富山県立

Clinical evaluation of electrolysis for Reis-

中央病院 呼吸器外科，3 富山県立中央病院 病

Bucklers Corneal Dystrophies and in vivo

理診断科）

histological analysis using anterior segment

臨床放射線，2 02 2 年 1 月；第 6 7 巻 1 号

optical coherence tomography
Nishino T，Kobayashi A，Mori N，Yokogawa H，

麻酔科

Sugiyama K

早期胃癌に対する 2 回の内視鏡的粘膜下層剥離術後の胃Cornea，2 02 1；4 0：9 58 ︲9 62

切除術時に予期せぬ胃内容充満があった症例
荒井理歩，吉田 仁，長岡治美，宇佐美潤，

放射線診断科那須倫範

Imaging findings of a case of intravascular large

日本臨床麻酔学会誌，

B-cell lymphoma with cardiac involvement

2 02 1；4 1 巻 7 号：5 59 ︲5 62

1

1

Yoshisuke Kadoya ，Shotaro Nagaoka ，Mao Kanatani 1，Risa Nagaoka 1，
2

7 6 歳，男性．3 年前よりインスリンなどで糖尿病治療中2であった．早期胃癌に対し，2 回の内視鏡的粘膜下層剥離

Naoto Maekawa ，Nao Terada ，3

3術（ ESD ）が施行された．非治癒切除のため，腹腔鏡下Noriharu Nakagawa ，Sayaka Kajikawa ，3

Hirokazu Okumura ，Shin Ishizawa

4

幽門側胃切除術が予定された．術前絶飲食時間は 1 2 時間

1

（ Department of Diagnostic Radiology, Toyama

であった．全身麻酔を導入し気管挿管を施行した．挿管時

2

口腔内に異物はなかった．経鼻胃管からは約 200 mL の食Division of Cardiology, Department of Internal

物残渣が吸引できた．手術開始後は胃の膨満を認めた．胃Medicine, Toyama Prefectural Central Hospital,

切除後に残胃内の食物残渣を約 7 00 g 除去した後，胃十二Prefectural Central Hospital, Toyama, Japan

3

Division of Hematology,

指腸吻合を行い，手術は終了した．2 回の広範囲な ESD や

Department of Internal Medicine, Toyama

糖尿病により，胃内容排出遅延が生じ，予期せぬ胃内容充4満があった．幸いにも誤嚥はなかったが，麻酔科医へ警鐘

Toyama, Japan

Prefectural Central Hospital, Toyama, Japan

Department of Diagnostic Pathology, Toyama

を鳴らす症例であった．

Prefectural Central Hospital, Toyama, Japan ）Radiology Case Reports，

胸腔鏡下肺切除術における術後悪心・嘔吐の検討：患者自己2 02 1 May 4；1 6（ 7 ）：1 78 0 ︲1 78 4

調節硬膜外鎮痛法と経静脈的患者自己調節鎮痛法との比較

doi: 1 0 .1 01 6 /j.radcr.2 02 1 .0 4 .0 30 .

那須倫範，吉田 仁，大石博史，荒井理歩，
小川浩平，松井 望

85

他誌掲載論文日 本 臨 床 麻 酔 学 会 誌，2 0 2 2 . 0 3；4 2 巻 2 号

Rare MYH9 -ROS1 Fusion Gene-Positive Lung

1 25 ︲1 30

Adenocarcinoma Showing Response to
Entrectinib Treatment: A Case Study.

胸腔鏡下肺切除術の術後鎮痛法（ patient-controlled

Tsuda T，Takata N，Hirai T，Masaki Y，epidural analgesia：PCEA と intravenous patient-

Ishizawa S，Taniguchi H．

controlled analgesia：IVPCA ）における術後悪心・嘔吐（ 富山県立中央病院 呼吸器内科，病理診断科）（ postoperative nausea and vomiting：PONV ）を後ろ向

Case Rep Oncol，2 02 2；1 5：3 76 ︲3 81

き に 比 較 し た．7 2 人 が PCEA（ E 群 ） で，8 6 人 がIVPCA（ V 群）で管理された．術翌日までの PONV 発生

画像技術科， 制 吐 薬 投 与 率，率（ E 群：1 2 .5 ％，V 群：1 5 .1 ％）Use of optically stimulated luminescence

PONV による鎮痛法の中止率は 2 群間に有意差を認めな

dosimeterand radiophotoliminescent glass

か っ た．IVPCA は PCEA と 比 べ PONV を 増 加 さ せ な

dosimeter for dose measurement in dual‑source

かった．

dual‑energy computed tomography
Ayaka Hirosawa，Kosuke Matsubara，ロボット支援下腹腔鏡前立腺全摘術における循環動態の経

Yusuke Morioka，Masayasu Kitagawa，

時的変化についての検討

Thunyarat Chusin，Akihiro Takemura

那須倫範，吉田 仁，山田正名，大石博史，

Physical and Engineering Sciences in Medicine，

荒井理歩，牛尾和弘，寺崎敏治

2 02 1；4 4：1 31 1 ︲1 31 9

（ 富山県立中央病院 麻酔科）
麻酔，2 02 1 . 0 4；7 0 巻 4 号：3 87 ︲3 91

We aimed to evaluate properties of optically stimulated
luminescence dosimeters (OSLDs) andロボット支援下腹腔鏡前立腺全摘術（ robot-assisted

radiophotoluminescent glass dosimeters (RPLDs) used inlaparoscopic prostatectomy:RALP ）における気腹と高度

dual-source dual-energy (DE) computed tomography

頭低位による影響を，フロートラックセンサー（ エドワー

(DECT) dosimetry. Energy dependence was evaluated in

ズライフサイエンス，東京）を用いて後ろ向きに検討した．

single-energy (SE) and DE modes, and their relative dose

頭低位角度の平均は 2 6 .8 °であった．心係数（ cardiac

responses differed by 3 .8 % and 6 .6 % under equivalentindex:CI ）は頭低位後より有意に低下し，頭低位後 6 0 分

effective energy with OSLD and RPLD, respectively. Dose

で最小（ 1 .5 4 ± 0 .4 1 l・min-1・m-2 ）となった．RALP

variation was evaluated using coefficients of variation ofにおいて，頭低位中の心拍出量の減少が示唆された．CI

dose values from 1 0 dosimeters, and dose variation ofの低下による合併症は認めなかったが，術中はモニタリン

OSLD and RPLD in SE mode ranged from 2 .1 to 3 .0 %グを行い，循環動態の変化に注意する必要がある．

and from 2 .1 to 2 .8 %, and those in the DE mode were 1 .8
and 2 .6 %, respectively. Dose linearity was evaluated from

病理診断科

1 to 1 5 0 mGy, and linear relationships of dose response

Imaging findings of a case of intravascular large

were observed between the dosimeters and the ionization

B-cell lymphoma with cardiac involvement.

chamber (correlation coefficients ≥ 0 .9 99 1 ). Angular

Kadoya Y，Nagaoka S，Kanatani M，Nagaoka R，dependence was evaluated from － 90 °to + 90 °, and it was

Maekawa N，Terada N，Nakagawa N，Kajikawa S，smaller in DE mode than in SE mode for OSLD. The

Okumura H，Ishizawa S.

normalized response of RPLD was higher at ± 30 °and ±（ 富山県立中央病院 放射線診断科，血液内科，

60 °and lower at － 90 °in SE and DE modes. This study

病理診断科）

demonstrated both OSLD and RPLD can perform dosimetryRadiol Case Rep，2 02 1；1 6：1 78 0 ︲1 78 4

in dual-source DECT with small influence of the propertiesof the dosimeters compared with that in SECT.