The 8 th International Symposium on
Drug Discovery and Design by NMR
Supported by Yokohama NMR Association
Period: August 26 (Mon) – 27 (Tue), 2024
Venue: RIKEN Yokohama Institute Main Lecture Hall (Koryuto Hall)
Access: http://www.yokohama.riken.jp/english/access/index.html<August 26 (Mon), 2024>

Program

10:00-10:10 Opening address: Hiroki Matsuo (Policy Adviser to the Cabinet)
Chairperson: Ei-ichiro Suzuki (Kihara Memorial Yokohama Foundation)
10:10-11:00 Peter Wright (The Scripps)
Transthyretin amyloidosis: Mapping the transthyretin aggregation landscape by NMR.
11:00-11:30 Tomohide Saio (Tokushima Univ.)
Mechanistic insight into concerted action of a chaperone complex.
11:30-12:00 Hideo Takahashi (YCU)
NMR analysis for the proton releasing mechanism of a light-driven membrane protein.
12:00-12:30 Takanori Kigawa (RIKEN)
Molecular observation in the native cellular environment by NMR.
12:30-13:30 Lunch
Chairperson: Chiaki Nishimura (Teikyo Heisei Univ.)
13:30-14:20 Tatiana Kutateladze (University of Colorado School of Medicine)
Structural mechanisms of epigenetic regulation.
14:20-14:50 Yoshifumi Nishimura (YCU)
Histone tail cross talks in a nucleosome.
14:50-15:40 Jane Dyson (The Scripps)
Disorder Rules: Transcription Factors.
15:40-16:00 Intermission
Chairperson: Takahisa Ikegami (YCU)
16:00-16:30 Hanaho Kano (Daiichi Sankyo Co., Ltd.)How computational chemistry can contribute to SBDD with NMR data.
16:30-17:00 Saeko Yanaka (Tokyo Tech)
Biophysical characterization of dynamic structures and interactions of immunoglobulin G
glycoproteins as therapeutic antibodies.
17:00-17:50 Christian Griesinger (Max-Planck Institute)
Small molecules triggering bacterial signal transduction and slowing neurodegeneration.
18:30-20:30 Banquet at Yone-sushi (Fees: 7,000 JPY)

<August 27 (Tue), 2024>
Chairperson: Hideo Akutsu (YCU)
9:30-10:20 Christina Hilty (Texas A&M Univ.)
Biomolecular Interactions Studied by Parahydrogen Polarization in Homogeneous andHeterogeneous Media.
10:20-10:50 Makoto Negoro (Osaka Univ.)
Dissolution triplet dynamic nuclear polarization and its application to protein-ligand interaction
analyses.
Chairperson: Tsuyoshi Konuma (YCU)
10:50-11:20 Kenji Sugase (Kyoto Univ.)
NMR study of α-synuclein amyloid fibril formation and inhibition.
11:20-11:50 Koh Takeuchi (Univ. Tokyo)
Affinity-directed substrate/H+ antiport of a MATE transporter.
11:50-12:40 Wolfgang Jahnke (Novartis)
New applications of NMR in drug discovery research.
12:40-13:40 Lunch
Chairperson: Arata Saso (Asahi Kasei Pharma)
13:40-14:30 Juli Feigon (UCLA)
Structural biology of telomerase mechanism and interactions at telomeres.
14:30-15:00 Shunsuke Imai (RIKEN)
Dynamically regulated two-site interaction of viral RNA to capture host translation initiation
factor.
15:00-15:30 Masato Katahira (Kyoto Univ.)
In-Cell NMR of Nucleic Acids and Inhibition of Cytidine-Deamination of APOBEC by HIV
Vif Complex
15:30-15:50 Intermission
Chairperson: Hiroyuki Hanzawa (Daiichi-Sankyo Co., Ltd.)
15:50-16:40 Mitsuhiko Ikura (Univ. Toronto)
Targeting the untargetable: RAS in cancer.
16:40-17:30 Gerhard Wagner (Harvard)
Elucidating the mechanisms of cancer metastases.
17:30-17:40 Closing■Registration fees: Free for active members, 5,000 JPY per person for non-active members.
■Banquet fees: 7,000 JPY per person.
Chairman: Yoshifumi Nishimura (Yokohama NMR Association)
TEL: 045-508-7211/7381, FAX: 045-508-7360
E-mail: nisimura@yokohama-cu.ac.jp (Nishimura)yokohamanmr@yokohama-cu.ac.jp (Secretariat)
Web: http://www.tsurumi.yokohama-cu.ac.jp/ynmr/