A Message From the Dean of Faculty of Medicine andGraduate School of Medicine, the University of Tokyo
The University of Tokyo’s Faculty of Medicine traces its origins back to the establishment of asmallpox vaccination post at Kanda-Otamagaike in 1858, more than 160 years ago. That is how far
back its history and traditions go, and how long it has supported modern medical education and has
sent forth healthcare practitioners and researchers who have made outstanding contributions to thedevelopment of medical science and clinical practice in Japan.
During the period 1995-1997, the school reorganized around its graduate-level programs, and in2004 the University of Tokyo became a national university corporation. For the past few years, thehospital’s facilities have been under redevelopment; in 2018 Inpatient Ward B opened, and in 2019
Clinical Research Center Building A was completed with study rooms, offices, and laboratories forclinical departments. Renovation of the South Clinical Research Building is now complete, and it now
has a special auditorium for clinical lectures, the Tetsumon Clinical Lecture Hall. We now also have afacility dedicated to multidisciplinary research for innovation in molecular life sciences and academiaindustry collaboration, which is also used by departments of the University of Tokyo’s School ofEngineering and School of Science, among others. With these improved facilities for teaching, research,and clinical care, the infrastructure is in place for great leaps forward.
The Faculty of Medicine has both a medical school and a School of Integrated Health Sciences.
They aim to contribute to progress in the life sciences, medical science, and medical care, and to train
future global leaders in those fields. In other words, through creative research they seek the truths thatwill help solve the problems in those fields, which will, when applied clinically, facilitate holistic
healthcare. The Faculty of Medicine’s Medical School has an initial (first-year) enrollment of 110. With
the aim of obtaining a license to practice medicine, students learn about the structure of the humanbody and the mechanisms of pathogenesis. The School of Integrated Health Sciences has a first-year
enrollment of 44. By studying the prevention of disease and the relations of health with society andthe environment, these students learn to create and develop the nursing and health sciences.
The purpose and guiding ideal of the Graduate School of Medicine is to advance humanunderstanding of the mechanisms of biological phenomena, and thereby to conquer disease andpromote health, and to do so through education, research, and training of international leaders who
use their exemplary knowledge in all areas of medicine to do innovative advanced research. To that
end, our many laboratories are international leaders in research at the frontiers of medical science andhealthcare. Medical students – the next generation of researchers – stimulate and are stimulated bytheir colleagues as part of these efforts through their participation in research.
Thus, we continue on our missions to provide the best possible medical care to patients in needtoday and to train top-level research scientists who will lay the foundations of medicine for tomorrow.

Nobuhito Saito, MD,PhD
Dean, Faculty of Medicine and Graduate School of Medicine,
The University of Tokyo

HISTORY
1858

May
Nov.

Practitioners, trained in Dutch (European) medicine in Edo (Tokyo), laid out money to establish
the Shutojo (vaccination center) in Kanda Mitamagaike.
Shutojo was destroyed in a fire that had spread from Kanda Aioicho. Shutojo continued its
operations at other sites such as the residence of Ito Genboku.

1859

Sep.

Shutojo was reconstructed at Shitaya Izumibashi Dohri.

1860

Oct.

Shutojo became an official medical institution of the Shogunate Government.

1861

Oct.

Shutojo was renamed as Seiyo Igaku-Sho (Institute of Western Medicine) and offered coursesof Western Medicine in the fields of Education, Autopsy, and Vaccination.

1863

Feb.

Seiyo Igaku-Sho was renamed as Igaku-Sho (Institute of Medicine).

1868

Jul.

Igaku-Sho, affiliated with the Military Hospital which had been moved from Yokohama to Todo
residence in Shitaya, was renamed as Daibyoin (the Great Hospital).

1869

Feb.
Dec.

The Daibyoin was renamed as Igakko-Ken-Byoin (Medical School and Hospital).
Igakko-Ken-Byoin was renamed as Daigaku Toko (University East Building).

1871

Jul.

The Ministry of Education was established and Daigaku-Toko was renamed as Toko (East
Building).

1872

Aug.

A School System was established. Toko was renamed as Daiichi-Daigaku-Ku- Igakko (The First
University District Medical School).

1874

May

Daiichi-Daigaku-Ku-Igakko was renamed as Tokyo-Igakko (Tokyo Medical School).

1876

Nov.

Tokyo-Igakko was moved to Hongo.

1877

Apr.

Tokyo Igakko, affiliated with Tokyo-Kaisei School, was renamed as The University of Tokyo.
Tokyo Medical School was renamed as The University of Tokyo Faculty of Medicine.

1886

Mar.

The University of Tokyo was renamed as Imperial University, and The University of Tokyo
Faculty of Medicine was renamed as the Imperial University Medical College. A Graduate
School was established.

1897

Jun.

The Imperial University was renamed as Tokyo Imperial University.

1917

Aug.

Eiraku Hospital, affiliated with the Ministry of Education Medical Practice License Examination,
moved to Tokyo Imperial University and was renamed as Koishikawa Hospital affiliated with
Tokyo Imperial University Medical College.

1919

Apr.

A faculty system was established renaming Tokyo Imperial University Medical College as theFaculty of Medicine.

1931

Feb.

The first building of the Faculty of Medicine was constructed.

1936

Jan.
Nov.

The Brain Research Laboratory was built with funds donated by Mr. Hisasaburo Horikoshi.
The second building of the Faculty of Medicine (main building) was constructed.

1947

Oct.

Tokyo Imperial University was renamed as The University of Tokyo.

1950

Apr.

The Institute of Nursing was renamed as The University Nursing School.

1953

Apr.
Jul.

The School of Health Care and Nursing was founded.
The Graduate School was founded, and the Division of Medical Doctor Biological Science wasestablished. The Brain Research Laboratory became the Brain Research Institute of the Facultyof Medicine.

1956

Apr.

The Midwives School was established.

1958

Apr.
May

The Division of Pharmaceutical Sciences became an independent faculty.
The University of Tokyo Faculty of Medicine celebrated its centennial anniversary.

1961

Mar.

The Medical Library was built in commemoration of the centenary.

Apr.

The Institute of Medical Electronics was established.

Apr.

The Research Institute of Logopedics and Pediatrics was established. The School of Health Careand Nursing was reorganized as the School of Health Sciences. The Graduate School of The
University of Tokyo was reorganized and the Division of Medical Doctor Biological Science
became the Faculty of Medicine. The Health science Course was established in the Medical
Science Division.

1965

2

1966

Sep.

The third building of the Faculty of Medicine was constructed.

1971

Apr.

The Laboratory of Animal Experiments was established.

1973

Mar.

The Animal Center for Biomedical Research was constructed.

1983

Jan.

An annex of the third building of the Faculty of Medicine was constructed.

1985

Sep.

The office of International Academic Affairs was established.

1987

Apr.

Specialized courses were introduced to the Graduate School of Medicine.

1992

Apr.

The School of Health Sciences became the School of Health Science and Nursing. The Schoolof International Health was established in the Medical Science Division.
The Radiation Research Institute was established.

Jul.
1995

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, four divisions,Third Basic Medicine, Social Medicine, Third and Fourth Clinical Medicine, were replaced with
Pathology, Immunology and Microbiology, Social Medicine, Reproduction and Development,
and Aging Science and Surgery.

1996

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First Clinical Medicine, Health Science, and International Health, were replaced with Internal
Medicine, Health Science and Nursing, and International Health.

1997

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First and Second Basic Medicine, and Second Clinical Medicine, were replaced with Molecular
Cell Biology, Functional Biology, Radiology and Biomedical Engineering, and Neuroscience.
As a result of the above-mentioned reorganization, three institutes, the Institute of Brain
Research, the Institute of Medical Electronics, and the Institute of Logopedics and Phoniatrics
were made redundant.

		

1999

Apr.

The Master course of Medical Science was established in the Graduate School of Medicine.
This course accepts graduates of all faculties except those from Schools of Medicine, Dentistry,and Veterinary Medicine.

2000

Apr.

The International Research Center for Medical Education was established (A shared facility foreducation and research).

2001

Apr.

The University Branch Hospital was united with the University Hospital.

2002 Mar.
		

Nursing School and Midwives School was closed.
Experimental Building (First Stage) was constructed.

2003 Apr.
		The Center for Disease Biology and Integrative Medicine was established.
The Radiation Research Institute and the Laboratory of Animal Experiments were integrated
into the Center for Disease Biology and Integrative Medicine.

2004

Apr.

All the National Universities owned by the Japanese Government became National University
Corporations. and the University of Corporation.

2005

Mar.

Experimental Building (Second Stage) was constructed.

2007

Apr.

The School of Public Health was established. This school offers programs for Master of Public
Health.

2008

May.

The University of Tokyo Faculty of Medicine and the University of Tokyo Hospital celebrated
their 150th anniversary.

2010

Apr.

The School of Health Science and Nursing became the School of Integrated Health Sciences.

2011

Jan.

The Museum of Health and Medicine was established.

2012

Apr.

The Office for Research Ethics Support was established.

2013

Apr.

The International Research Center for Medical Education became a facility of the Graduate
School of Medicine.

2013

Oct.

The Life Sciences Core Facility was established.

2015

Apr.

The Office for Clinical Practice and Medical Education was established.

2017

Apr.

The Global Nursing Research Center was established.

3As of May, 2019

Graduate School of Medicine

Dean Nobuhito Saito

Molecular Cell Biology
P14

Cell Biology andAnatomyBiochemistry andMolecular Biology*Collaborative Department

Cell Biology
Professor
Masahide Kikkawa
Structural Biology
Professor
Masahide Kikkawa
Structural Cell Biology
Cellular Neurobiology
Professor
Shigeo Okabe
Molecular Biology
Professor
Noboru Mizushima
Cellular Signaling
Professor
Makoto Murakami
Physiological Chemistry and Metabolism Professor
Hiroki Kurihara
Advanced Structural Biology
Professor
Danev Radostin
Clinical Genome Informatics / Lipid Science/Cancer Cellular Signaling

Functional Biology
Physiology
P17

Pharmacology*Collaborative Department

Professor
Integrative Physiology
Cellular and Molecular Physiology Professor
Professor
Neurophysiology
Cellular and Molecular Pharmacology Professor
Professor
Systems Pharmacology
Brain Functional Dynamics

Kenichi Ohki
Masanori Matsuzaki
Masanobu Kano
Kenzo Hirose
Hiroki Ueda

Pathology, Immunology and Microbiology
P19

Pathology

Pathology and Diagnostic Pathology Professor
Molecular Pathology
Professor

Microbiology
Immunology

Microbiology
Infection Control and Prevention
Immunology*Collaborative Department

Tumor Pathology / Infection Pathology / Molecular Oncology

Associate Professor
Professor
Professor
Professor
Associate Professor

Tetsuo Ushiku
Kohei Miyazono
Daizo Koinuma
Masanori Hatakeyama
Kyoji Moriya
Hiroshi Takayanagi
Takeshi Nitta

Radiology and Biomedical Engineering
Radiology

Diagnostic Radiology

Biomedical Engineering

Radiotherapy
Nuclear Medicine
System Physiology

P21

Chemical Biology and Molecular Imaging*Collaborative Department

Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Osamu Abe
Harushi Mori
Keiichi Nakagawa
Hidemasa Takao
Kiyoshi Miyagawa
Kimiko Yamamoto
Yasuteru Urano
Mako Kamiya

Biosystem Construction and Control

Neuroscience
Basic Neuroscience
P23

Integrative Medical
Neuroscience
Clinical Neuroscience

Neuropathology
Neurochemistry
Neurobiology
Developmental Neuroscience
Cognitive Neuroscience
Systems Medical Neuroscience
Child Neuropsychiatry
Neuropsychiatry
Neurology
Neurosurgery*Collaborative Department

4

Biomedical Neural Dynamics

Professor
Professor

Takeshi Iwatsubo
Haruhiko Bito

Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Yukiko Kano
Kiyoto Kasai
Seiichiro Jinde
Tatsushi Toda
Atsushi Iwata
Nobuhito Saito
Hirofumi Nakatomi

Social Medicine

P26

Occupational,
Environmental andPreventive Medicine
Forensic Medicine, andMedical Informatics andEconomics*Collaborative Department

Preventive Medicine
Public HealthRadiological HealthForensic Medicine

Professor
Associate Professor
Professor
Associate Professor

Shumpei Ishikawa
Hiroto Katoh
Yasuki Kobayashi
Satoshi Toyokawa

Professor
Associate Professor
Professor

Hirotaro Iwase
Yohsuke Makino
Kazuhiko Ohe

Professor

Issei Komuro

Biomedical Informatics
Cancer Control Policy and Research/Cancer Epidemiology/Cancer Communication

Internal Medicine
Medicine I
P28

Cardiovascular Medicine
Vascular Biology
Respiratory Medicine
Gastroenterology
Nephrology
Endocrinology
Nutrition and Metabolism
Hematology and Oncology
Allergy and Rheumatology
Infectious Diseases

Clinical Laboratory
Medicine and Pathology

Professor
Professor
Professor
Professor
Professor
Professor
Professor
Professor
Associate Professor
Stress Science and Psychosomatic Medicine Associate Professor
Clinical Laboratory Medicine
Professor
Transfusion Medicine
Professor*Collaborative Department

Molecular Diabetology

Medicine II

Takahide Nagase
Kazuhiko Koike
Masaomi Nangaku
Masaomi Nangaku
Toshimasa Yamauchi
Mineo Kurokawa
Keishi Fujio
Kyoji Moriya
Syu Okugawa
Kazuhiro Yoshiuchi
Yutaka Yatomi
Hitoshi Okazaki

Reproductive, Developmental and Aging Sciences

P32

Obstetrics andGynecology

Pediatric Sciences

Reproductive Endocrinology

Professor
Associate Professor
Associate Professor
Gynecological Oncology
Associate Professor
Perinatal Medicine
Molecular Cellular Reproductive Medicine Professor
Associate Professor
Professor
Pediatrics
Associate Professor
Professor
Developmental Pediatrics
Professor
Pediatric Surgery

Tomoyuki Fujii
Takeshi Nagamatsu
Katsutoshi Oda
Kaori Koga
Yutaka Osuga
Osamu Hiraike
Akira Oka
Yutaka Harita
Naoto Takahashi
Jun Fujishiro

Aging Sciences

Pediatric Oncology
Geriatric Medicine*Collaborative Department

Aging Research
Health Policy for Children and Families/Medical Science for Life and Aging

Professor
Associate Professor
Professor

Masahiro Akishita
Sumito Ogawa
Masahiro Akishita

Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Jun Nakajima
Minoru Ono
Yasutaka Hirata
Yasuyuki Seto
Sachiyo Nomura
Kiyoshi Hasegawa
Junichi Arita
Haruki Kume
Motofumi Suzuki

Surgical Sciences
P35

Thoracic Surgery
Cardiovascular Surgery
Gastrointestinal Surgery
Hepatobiliary Pancreatic Surgery
Urology
Artificial Organ and Transplantation Division5

Surgical Sciences
Surgery

Sensory and Motor
System Medicine

Vital Care Medicine

Surgical Oncology
Vascular Surgery
Breast and Endocrine Surgery
Dermatology

Professor
Associate Professor
Professor

Professor
Associate Professor
Plastic and Reconstructive Surgery Professor
Associate Professor
Professor
Oral and Maxillofacial Surgery
Associate Professor
Professor
Orthopaedic Surgery
Associate Professor
Professor
Ophthalmology
Associate Professor
Associate Professor
Otolaryngology and Head and Neck Surgery Professor
Associate Professor
Associate Professor
Professor
Rehabilitation Medicine
Associate Professor
Associate Professor
Anesthesiology
Professor
Acute Medicine

Soichiro Ishihara
Hiroaki Nozawa
Soichiro Ishihara
Shinichi Sato
Yoshihide Asano
Mutsumi Okazaki
Takuya Iida
Kazuto Hoshi
Hideto Saijo
Sakae Tanaka
Taku Saito
Makoto Aihara
Satoshi KatoToshikatsu Kaburaki
Tatsuya Yamasoba
Shinichi Iwasaki
Kenji Kondo
Nobuhiko Haga
Yusuke Shinoda
Kanji Uchida
Naoto Morimura

Health Sciences and Nursing
Health Sciences
P42

Health Sociology
Mental Health
Epidemiology and Preventive Health
Sciences
Biostatistics
Health Education
Health Promotion Sciences
Biomedical Ethics

Preventive andAdministrative Nursing

Clinical Nursing

Advanced Clinical Nursing
Nursing Administration
Family Nursing
Community Health Nursing
Public Health Nursing
Gerontological Home Care andLong-term Care Nursing
Palliative Care Nursing
Midwifery and Women's Health
Psychiatric Nursing
Gerontological Nursing*Collaborative Department

6

Wound Care Management
Public Mental Health Policy

Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Naoki Kondo
Norito Kawakami
Daisuke Nishi
Yutaka Matsuyama
Koji Oba
Yutaka Matsuyama
Koji Oba
Hideki Hashimoto

Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Professor

Akira Akabayashi
Yoshiyuki Takimoto
Yukie Takemura
Yukie Takemura
Kiyoko Kamibeppu
Noriko Yamamoto-Mitani

Professor

Noriko Yamamoto-Mitani

Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Noriko Yamamoto-Mitani
Megumi Haruna
Norito Kawakami
Yuki Miyamoto
Hiromi Sanada
Gojiro Nakagami
Hiromi Sanada

International Health
P46

International
Social Medicine
International
Biomedical Sciences

Global Health Policy
Community and Global Health
Human Genetics
Developmental Medical Sciences

Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Masamine Jimba
Akihiko Mabuchi
Masashi Mizuguchi
Teruyuki Tanaka
Masahiro Umezaki
Shoko Konishi
Tomoyoshi Nozaki
Yoh-ichi Watanabe

Professor
Associate Professor
Social and Preventive Epidemiology Professor
Clonical Epidemiology and Health Economics Professor
Health Communication
Professor
Associate Professor
Mental HealthProfessor
Associate Professor
Health Sociology and Health Education Associate Professor
Health and Social Behavior
Professor

Yutaka Matsuyama
Koji Oba
Satoshi Sasaki
Hideo Yasunaga
Takahiro Kiuchi
Tsuyoshi Okuhara
Norito Kawakami
Daisuke Nishi
Naoki Kondo
Hideki Hashimoto

Human Ecology
Biomedical Chemistry

School of Public Health
P49

Epidemiology and
Health Sciences

Behavioral Health
Sciences

Biostatistics

Health Promotion Sciences
Biomedical Ethics

Health Services Sciences*Collaborative Department

Professor
Associate Professor
Health Policy
Professor
Associate Professor
Healthcare Informatics
Professor
Clinical Information Engineering
Professor
Forensic Medicine and Medical Law Professor
Associate Professor
Global Environmental Health
Associate Professor

Public Health Science

Center for Disease Biology and Integrative Medicine
Laboratory of Molecular Biomedicine for Pathogenesis

P53

Laboratory of Structural Physiology
Laboratory of Biomedical Equipment and Biomaterial
Laboratory of Clinical Biotechnology
Laboratory of Environmental and Metabolic Health Sciences
Laboratory of Animal Resources
Laboratory of Molecular Radiology
Laboratory of Biomedical Infomatics

Director Masanobu Kano
Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor

The International Research Center for Medical Education
P56

Akira Akabayashi
Yoshiyuki Takimoto
Yasuki Kobayashi
Satoshi Toyokawa
Kazuhiko Ohe
Hiroshi Oyama
Hirotaro Iwase
Yohsuke Makino
Yoonhee Kim

Department of Medical Education
Professor
Department of International Cooperation for Medical Education

Toru Miyazaki
Satoko Arai
Haruo Kasai
Taichi Ito
Ungil Chung
Makoto Murakami
Seiichiroh Ohsako
Atsu Aiba
Kazuki Nakao
Hidetoshi Kassai
Kiyoshi Miyagawa
Noriko Hosoya
Takeshi Imai

Director Tatsuya Yamasoba
Masato Eto

7

Global Nursing Research Center
P57

Division of Care Innovation

Division of Nursing System

Director Hiromi Sanada
Professor
Hiromi Sanada
Project Professor
Taketoshi Mori
Associate Professor
Gojiro Nakagami
Project Associate Professor Takeo Minematsu
Project Associate Professor Nao Tamai
Project Associate Professor Ryoko Murayama
Project Associate Professor Makoto Oe
Professor
Noriko Yamamoto-Mitani
Professor
Kiyoko Kamibeppu
Associate Professor
Yukie Takemura
Associate Professor
Yuki Miyamoto
Associate Professor
Megumi Haruna

Institution
P58

The Office of International Academic Affairs
Medical Scientist Training Program
Office for Human Research Studies
Life Sciences Core Facility
The Office for Clinical Practice and Medical Education
Medical LibraryMuseum of Health and Medicine

Head
Head
Director
Vice Director
Head
Head
Head
Head

Shinichi Sato
Haruhiko Bito
Masaomi Nangaku
Akira Akabayashi
Yoshihiro Kita
Masato Eto
Hideo Yasunaga
Kazuhiko Ohe

Endowed Department
Department of Bone & Cartilage Regenerative Medicine
Department of Cell & Tissue Engineering(Fujisoft)
Immunotherapeutics
Department of Advanced Clinical Science and Therapeutics
Computational Diagnostic Radiology and Preventive Medicine
Clinical Trial Data Management
Ubiquitous Preventive Medicine
Science for Joint Reconstruction
Therapeutic Strategy for Heart Failure
Molecular Structure and Dynamics (JEOL / Zeiss)
Department of Medical Genomics
Continence Medicine
Department of Life Support Technology (Molten)
Department of Advanced Translational Research andMedicine in Management of Pulmonary Hypertension
Department of Immunotherapy Management
Department of medical research and management formusculoskeletal pain
Department of Molecular Science on Diabetes
Department of Osteoimmunology
Health Economy and Society Policy
Department of medical and pharmaceutical community healthcare
Department of Molecular Neurology
Laboratory for New Generation Drug Discovery
Department of Biostatistics and Bioinformatics

8

Project Associate Professor
Project Associate Professor
Project Professor
Project Associate Professor
Project Professor
Project Associate Professor
Project Associate Professor

Fumiko Yano
Atsuhiko Hikita
Kazuhiro Kakimi
Mutsuo Harada
Naoto Hayashi
Kansei Uno
Takeharu Yoshikawa

Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Professor

Yuichi Ikeda
Toru Moro
Masaru Hatano
Nobutaka Hirokawa

Project Professor
Yasuhiko Igawa
Project Professor
Taketoshi Mori
Project Associate Professor Haruhiro Toko
Project Associate Professor Hiroko Kanda
Project Professor
Koh Matsudaira
Project Associate Professor Hiroyuki Oka
Project Associate Professor
Project Professor
Project Professor
Project Professor
Project Associate Professor
Project Associate Professor
Project Professor
Project Associate Professor

Kazuo Okamoto
Tomoyuki Takura
Hirohisa Imai
Seiji Tsuji
Jun Mitsui
Hideaki Ando
Daisuke Koide
Akihiro Hirakawa

Laboratory for Advanced Research on Pathophysiology ofMetabolic Diseases
Department of Preventive Medicine for Locomotive Organ Disorders
Department of Home Care Medicine
Department of Advanced Cardiology
Artificial Intelligence in Healthcare

Project Associate Professor
Project Associate Professor
Project Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor

Miki Iwabu
Masato Iwabu
Noriko Yoshimura
Takashi Yamanaka
Katsuhito Fujiu
Yoshimasa Kawazoe

Project Associate Professor
Project Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Professor
Project Associate Professor
Department of Next-Generation Pathology Information Networking Project Professor
Chronic kidney disease pathophysiology
Project Professor

Kayo Waki
Yoshiya Oda
Ryoko Murayama
Shinichi Tokuno
Taisuke Jo
Takeo Minematsu
Hiroaki Miyata
Susumu Aikou
Nao Tamai
Tadafumi Hashimoto
Tomohisa Okamura
Takashi Kadowaki
Satoko Yamaguchi
Takeshi Sasaki
Reiko Inagi

Social Cooperation Program
Department of Ubiquitous Health Informatics
Department of Lipidomics
Advanced Nursing Technology
Verbal analysis of pathophysiology
Department of Health Services Research
Skincare Science
Department of Healthcare Quality Assessment
Bariatric & Metabolic Care
Imaging Nursing Science
Department of Innovative Dementia Prevention
Department of Functional Genomics and Immunological Diseases
Department of Prevention of Diabetes and Life-style Related Diseases

Research Unit
Global Leader Program for Social Design and Management

Faculty of Medicine

Project Associate Professor Jung Su Lee

Dean Nobuhito Saito

School of Medicine

Cell Biology and Anatomy / Biochemistry and Molecular Biology / Physiology /Pharmacology / Pathology / Microbiology / Immunology / Radiology /Biomedical Engineering / Basic Neuroscience / Integrative Medical Neuroscience /Clinical Neuroscience / Occupational, Environmental and Preventive Medicine /Medical Principles and Medical Ethics / Forensic Medicine, and Medical
Informatics and Economics / Medicine I / Medicine II / Clinincal Laboratory
Medicine and Pathology / Obstetrics and Gynecology / Pediatric Science /Aging Science / Sugery / Sensory and Motor System Medicine / Vital Care
Medicine

School of
Integrated Health
Sciences

Family Nursing / Community Health Nursing / Fundamental Nursing /Gerontological Nursing / Midwifery and Women's Health /Adult Health and Nursing / Mental Health and Nursing / Health Sociology /Health Administration / Epidemiology and Biostatistics / Human Ecology /Biochemistry and Nutrition / Maternal and Child Health9University Hospital

Director Yasuyuki Seto

Clinical Division
Department ofInternal Medicine

General Medicine
Cardiovascular Medicine
Respiratory Medicine
Gastroenterology
Nephrology and Endocrinology
Diabetes and Metabolic Diseases
Hematology and Oncology
Allergy and Rheumatology
Infectious Diseases
Neurology
Geriatric Medicine
Psychosomatic Medicine

Department ofSurgery

General Surgery
Stomach and Esophageal Surgery
Colon and Rectal Surgery
Hepatobiliary Pancreatic Surgery
Vascular Surgery
Breast and Endocrine Surgery
Artificial Organ and Transplantation Surgery
Cardiovascular Surgery
Thoracic Surgery
Neurosurgery
Anesthesiology and Pain Relief Center
Urology and Andrology
Gynecologic Surgery

Department ofsensory andMotor System Medicine

Dermatology
Ophthalmology
Orthopaedic Surgery and Spinal Surgery
Otolaryngology and Head and Neck Surgery
Rehabilitation Medicine
Plastic, Reconstructive and Aesthetic Surgery
Oral-Maxillofacial Surgery and Orthodontics

10

Professor
Professor
Professor
Professor
Professor
Professor
Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Issei Komuro
Issei Komuro
Takahide Nagase
Kazuhiko Koike
Masaomi Nangaku
Toshimasa Yamauchi
Mineo Kurokawa
Keishi Fujio
Kyoji Moriya
Syu Okugawa
Tatsushi Toda
Atsushi Iwata
Masahiro Akishita
Sumito Ogawa
Akira Akabayashi
Kazuhiro Yoshiuchi
Yoshiyuki Takimoto
Soichiro Ishihara
Yasuyuki Seto
Sachiyo Nomura
Soichiro Ishihara
Hiroaki Nozawa
Kiyoshi Hasegawa
Junichi Arita
Soichiro Ishihara

Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Kiyoshi Hasegawa
Junichi Arita
Minoru Ono
Yasutaka Hirata
Jun Nakajima
Nobuhito Saito
Hirofumi Nakatomi
Kanji Uchida
Haruki Kume
Motofumi Suzuki
Yutaka Osuga
Katsutoshi Oda
Shinichi Sato
Yoshihide Asano
Makoto Aihara
Satoshi KatoToshikatsu Kaburaki
Sakae Tanaka
Taku Saito
Tatsuya Yamasoba
Shinichi Iwasaki
Kenji Kondo
Nobuhiko Haga
Yusuke Shinoda
Mutsumi Okazaki
Takuya Iida
Kazuto Hoshi
Hideto Saijo

Department ofPediatrics, Perinatal and
Women's Medicine

Pediatrics

Department of
Neuropsychiatry

Neuropsychiatry

Department ofRadiology

Radiology

Acute Medicine

Acute Medicine

Pediatric Surgery
Obstetrics and Gynecology

Professor
Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor

Akira Oka
Yutaka Harita
Jun Fujishiro
Tomoyuki Fujii
Kaori Koga
Osamu Hiraike
Takeshi Nagamatsu
Kiyoto Kasai
Seiichiro Jinde
Osamu Abe
Keiichi Nakagawa
Harushi Mori
Naoto Morimura

Central Clinical Facilities
Clinical Laboratory
Operation Center
Imaging Center
Department of Blood Transfusion
Perinatal Center
Rehabilitation Service
Department of Medical Engineering
Central Supply Service
Intensive Care Unit
Pathology
Department of Corneal Transplantation
Department of Cell Therapy and Transplantation Medicine
Department of Endoscopy and Endoscopic Surgery
Department of Hemodialysis and Apheresis
Infection Control and Prevention Service
Department of Planning, Information and Management
University Hospital Medical Information Network Center
Organ Transplantation Service
Labor Safety and Health Management OfficeChild Psychiatry
Tissue Bank
Epidemiology and Preventive medicine
Center for Liaison and Public Relations
Datebase Center of the National University Hospitals
Department of Chemotherapy
Department of Medical Record Management
Intensive Care Unit
Department of Palliative Medicine
Children's Medical Center
Department of Disaster Medical Management
International Medical Center
Department of Clinical Nutrition Therapy
Department of Chemotherapy
Department of Clinical Genomics
Pharmaceutical Department
Nursing Department
Administration Office

Professor
Yutaka Yatomi
Associate Professor Kazuhiko Fukatsu
Professor and Director Osamu Abe
Professor
Hitoshi Okazaki
Professor
Tomoyuki Fujii
Professor
Nobuhiko Haga
Associate Professor Yusuke Shinoda
Associate Professor
Professor
Professor
Professor
Professor
Professor
Professor
Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Professor

Kazuhiko Fukatsu
Naoto Morimura
Tetsuo Ushiku
Makoto Aihara
Mineo Kurokawa
Kazuhiko Koike
Masaomi Nangaku
Kyoji Moriya
Kazuhiko Ohe
Takahiro Kiuchi
Tsuyoshi Okuhara
Kiyoshi Hasegawa
Tomotaka Yamamoto
Yukiko Kano
Sumihito Tamura
Nobutake Yamamichi
Yutaka Osuga

Professor
Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Associate Professor
Professor
Professor
Professor
Professor
Professor

Kiyoshi Miyagawa
Kazuhiko Ohe
Naoto Morimura
Masahiko Sumitani
Akira Oka
Jun Fujishiro
Naoto Morimura
Sumihito Tamura
Naoto Kubota
Naoto Takahashi
Yutaka Osuga
Kiyoshi Miyagawa
Tatsushi Toda
Hiroshi Suzuki

11

Clinical Research Division
Clinical Research Support Center
22nd Century Medical and Research Center
Department of Tissue Engineering
Cooperative Unit of Medicine and Engineering Research
Translational Research Center
Center for Genome Medicine
Unit for Early and Exploratory Clinical Development

Professor
Takashi Moritoyo
Associate Professor Chie Sakanaka
Professor
Yutaka Osuga
Project Professor
Kazuhiro Kakimi
Professor
Kazuto Hoshi
Associate Professor Atsuhiko Hikita
Professor
Minoru Ono
Professor
Takeshi Iwatsubo
Professor
Yutaka Osuga
Project Associate Professor Nobuhiro Shojima
Professor
Takeshi Iwatsubo

Organization of Clinical Management Support
Department of Personnel Administration and Human Resource Management
Medical Specialists Training Center
Department of Performance Monitoring and Risk Management
Office of Performance Monitoring
Medical Safety management Center
Infection Control Center
Department of Highly Advanced Novel Medical Technologies Evaluation
Department of Unapproved New Drugs and Medical Devices Evaluation
Department of Education and Staff Development
General Education Center
Hospitality Center
Department of Hospital Planning and Management
Department of Research Support
Department of Clinical Research Gavernance

Professor

Yutaka Yatomi

Professor
Nobuhiko Haga
Associate Professor Tomotaka Yamamoto
Associate Professor Tomotaka Yamamoto
Professor
Kyoji Moriya
Professor
Jun Nakajima
Professor
Nobuhiko Haga
Professor
Tatsuya Yamasoba
Professor
Masato Eto
Professor
Professor
Project Professor

Jun Nakajima
Yutaka Osuga
Hideaki UiProfessor

Haruki Kume

Organization of Clinical Management
Inpatient Services Administration
Admission and Discharge Center
Cancer Board
Outpatient Services Administration
Central Clinical Services Administration
Vascular Board
Perioperative Assessment Center
Epilepsy Center
Immunotherapy Center
SSc Center
Osteoporosis Center
Hip Fracture Board
Division of patient support services
Medical Community Network and Discharge Planning Center
Cancer Resource Center
Patient Relations and Clinical Ethics Center

12

Professor
Kiyoshi Miyagawa
Professor
Kiyoshi Miyagawa
Associate Professor Masahiko Sumitani
Associate Professor Kanji Uchida
Project Associate Professor Hiroko Kanda
Associate Professor Yoshihide Asano
Associate Professor Taku Saito
Professor
Yutaka Osuga
Associate Professor Masahiko Sumitani
Associate Professor Sachiyo Nomura
Associate Professor Yoshiyuki Takemoto

Faculty of Medicine
Graduate School of
Medicine
The University of Tokyo

Graduate School of Medicine

Molecular Cell Biology.............................................. 14
Functional Biology..................................................... 17
Pathology, Immunology and Microbiology.................. 19
Radiology and Biomedical Engineering....................... 21
Neuroscience ..........................................................23
Social Medicine........................................................26
Internal Medicine . ...................................................28
Reproductive, Developmental and Aging Sciences . ....32
Surgical Sciences .....................................................35
Health Sciences and Nursing ....................................42
International Health .................................................46
School of Public Health ............................................49
Center for Disease Biology and Integrative Medicine...53
The International Research Center for
Medical Education.............................................56
Global Nursing Research Center................................57
Institution

58

The Office of International Academic Affairs
Medical Scientist Training Program
Office for Research Ethics Support
Life Sciences Core Facility
The Office for Clinical Practice and Medical Education
Medical LibraryMuseum of Health and Medicine

13

A
G
C
T
Molecular Cell Biology

Structural Biology

http://structure.m.u-tokyo.ac.jp/

Kikkawa lab is interested in eukaryotic flagella/cilia, which works as apropeller and a sensor of cells. We study regulatory mechanisms of flagella/cilia beating by combining cryo-electron microscopy, optical microscopy
with high-speed camera, cell biology, and genetics. We also provide cryoelectron microscopes as shared facilities.
Our current focuses are:
● How cilia/flagella are assembled.
● Molecular mechanisms of flagella and axonemal
dyneins.
● Provide cryo-electron microscopy as shared facility

Cryo-electron microscopies installed in the University of Tokyo.
From left to right: Titan Krios G3i (upper left), Talos Arctica (upper right),
Aquilos (FIB-SEM,lower left), JEOL JEM-F200 (lower right).

Structural Cell Biology

http://cb.m.u-tokyo.ac.jp/

Our laboratory aims to study the function of microtubule-based molecularmotors, kinesin superfamily proteins (KIFs). We have previously identified 45
KIF genes from human and mouse genomes. According to mouse molecular
genetics and structural biological analyses, we have identified their functional
relevance in higher brain function, brain wiring, left-right determination,
tumor suppressing pathway, metabolic diseases, and so on. However, there
still exist multiple interesting questions in this field, which we aim to solve by
multidisciplinary and comprehensive approaches.

The neuronal cytoskeleton and its associated organelles（From Nature Milestones 2008）14

Cellular Neurobiology
The Laboratory of Cellular Neurobiology is interested in understanding themolecular mechanisms regulating synapse formation and maintenance,
which are essential in proper function of neural circuits in the brain. The
laboratory is using optical imaging of synaptic molecules in live neurons, in
combination with molecular biological approaches to modify neuronal
functions.
Molecular architecture of the postsynaptic density
Molecular mechanisms of activity-dependent synapse remodeling● Regulation of synapse functions by glial cells● Regulation of synapse formation and maintenance in vivo
● Synapse dysfunction in psychiatric diseases●●

Quantitative fluorescence imaging of cultured
hippocampal neurons (green: postsynaptic protein andcalibrated fluorescent microspheres, red: presynaptic
protein, blue: microtubule-associated protein)

Molecular Biology
Our laboratory has been doing trans-disciplinary
studies on autophagy, an intracellular degradation
system, and trying to understand the mechanisms andbiological and pathophysiological functions ofautophagy.

http://molbiol.umin.jp/
Lysosome
Isolation membrane

Degradation
Amino acids
etc.

?
Autophagosome

Molecular mechanism of autophagy (its regulation,
membrane dynamism, selectivity, etc.)● Physiological and pathophysiological roles of
autophagy● Development of new methods for monitoring andmodulating autophagy

Protein synthesis
Energy production
Gluconeogenesis, etc●

Starvation adaptation, preimplantation development,
intracellular quality control, tumor suppression,
prevention of neurodegeration, degradation of invading
bacteria, antigen presentation
䋭/䋭

+/+

Cellular Signaling
Lipids serve as the largest energy source, cell membrane components,
and bioactive mediators. Lipids are major environmental substances
supplied as nutrients and spatiotemporally regulate a variety of
biological responses in response to given microenvironmental cues
within tissues. Our research focuses on the regulation of biologicalnetworks driven by lipids and their metabolites. By taking advantagesof an array of gene-manipulated mice for lipid-metabolizing enzymes
and receptors, we aim to clarify novel lipid-orchestrated mechanisms
underlying various diseases such as metabolic and immune
disorders. Knowledges obtained from these approaches will betranslated to humans toward discovery of new biomarkers or
druggable targets.

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15

Physiological Chemistry and Metabolism

http://bio.m.u-tokyo.ac.jp/

We are investigating cellular behavior and signaling mechanisms
underlying cell fate determination, morphogenesis andorganogenesis in embryonic development.
Mechanisms of neural crest fate determination andcraniofacial morphogenesis● Mechanisms of cardiac development● Mechanisms of angiogenesis●

Understanding morphogenesis and organogenesis
based on collective cell movement

Advanced Structural Biology
Our main interest is development of new methods and improvement ofexisting techniques for structure determination by cryo-electron microscopy(cryo-EM). Simultaneously, we are using state-of-the-art cryo-EM to study the
structures of "difficult" samples, such as membrane proteins, small (< 100kDa) molecules, heterogeneous samples and intact cellular volumes.
Cryo-EM is already past the tipping point and is being widely accepted andappreciated as a capable structural biology method. There are several areas
where further progress is expected and/or already ongoing. Instrumentation,
sample preparation, automation, deep learning and streamlining of theresearch process are of great interest to us and we are trying to contribute inthese directions.

The structures of G-protein coupled receptors (upper) andhemoglobin (lower) solved by cryo-electron microscopy

16

Functional Biology

Integrative Physiology
The cerebral cortex acquires complicated response selectivity by receiving
and processing information from the outside of the world. However, it is still
unknown what kind of neural circuit actually is involved this information
processing. In recent years, progress of imaging technology (two-photon
excitation method) has made it possible to simultaneously measure theactivity of thousands of nerve cells from a living animal (Ohki et al., 2005,
2006). In addition to that, various technologies for studying neural circuits
are being developed one after another and research on neuroscience isentering a transition era. In our laboratory, by using these latest methods,
we are trying to find out how the neural circuits of mammalian visual cortex
process information.
Functional organization in the visual cortex
Development of neural circuits in the visual cortex● Information representation in the visual cortex● Roles of each cell-type in the processing of visual information

http://www.physiol2.med.kyushu-u.ac.jp/
We clarify the functional unitary circuit, its
operation principle and formation principleof the cortex using two-photon imaging
and optogenetics.

Two-photon imaging

Unitary circuit
Functional Organization

Optogenetics

Elucidation of functional unitary circuitin the cortex
Methods: two-photon microscopy
with single-cell resolutionPeters & Payne 1993

Formation Principle
Interplay between innate factors
And activity-dependent processes
Methods: Genetic manipulations andOptogenetics

Operation Principle
Information representation and decoding
Methods:9Fast two-photon volume imaging●●

Cellular and Molecular Physiology

http://plaza.umin.ac.jp/~Matsuzaki-Lab/

Our laboratory studies the neural circuits in the frontal cortex, which emerge
movement and thought. Applying two-photon imaging, optogenetics, andelectrophysiology to behaving mice and marmosets, we measure andmanipulate the activities of multiple neurons and analyze their dynamics.
Neural circuits for motor learning and motor execution.
Neural circuits for decision making.
● Neural circuits for brain-machine-interface.
● Development of novel fluorescent microscopy system.
●●

Two-photon image ofthe mouse motor cortical neurons

17Neurophysiology
Our laboratory studies the function of the synapse, a key
structure for brain functions, and its changes related topostnatal development, learning, and memory. We
monitor neural activity in real time using various
methodologies including; electrophysiology, molecularbiology, and optical imaging of functional molecules.
Postnatal development of synaptic function andorganization in the cerebellum● Retrograde synaptic modulation mediated byendogenous cannabinoids● Synaptic integration in intact animals● Synaptic plasticity and motor learning in the
cerebellum●

http://plaza.umin.ac.jp/˜neurophy/〜P3
Purkinje cell

Parallelﬁbers

P12〜P17

P8〜P11

P4〜P7

Strengthened

Translocate

Translocate

Maintained

EliminatedEliminatedClimbing ﬁbers

Synapse formation
Multi-innervation

P18〜

Parallel ﬁber dependent

Functional
diﬀerentiation

Synapse elimination
Early phase

Late phase

Monoinnervation

P9〜 Climbing ﬁber translocation to dendrite

Postnatal development of climbing ﬁber to Purkinje cell synapses

Postnatal development of cerebellar climbing fiber to Purkinje cell synapses

Cellular and Molecular Pharmacology

http://www.pharmacol.m.u-tokyo.ac.jp/

The goal of our research is to elucidate the regulatory
mechanisms of physiological functions in the biologicalsystems, especially in the central nervous system, bydeveloping original bioimaging technologies including
glutamate imaging technology. Currently, we aredeveloping new basic technologies of molecular tag,super-resolution imaging and Ca 2+ imaging, andapplying the technologies to actual physiologicalstudies.

Systems Pharmacology
We are aiming at understanding of how multi-stability
and homeo-dynamics in sleep-wake systems, as amodel system, can be achieved through negative
feedback regulation of membrane potential in neurons,
and neural circuit structures. Also, we are establishinga high-throughput production platform of geneticallyengineered mice to facilitate a quantitative analysis andperturbation at the organismal level, and paving theway for the basic research by associating with humangenome analysis obtained from clinical studies.
Elucidation of the regulatory principle of sleep-wakerhythm● High-throughput production platform of geneticallyengineered mice
● Application of human genome analysis from clinicalstudies to basic research●

18

OrganismͲlevelSystemsBiologythrough
UnderstandingofSleepͲawakeCycle
Elucidationoftheregulatory
principleofsleepͲwakerhythmHighͲthroughputplatformofgeneticallyengineeredmice

Applicationofclinicalstudies
tobasicresearch

AdvancedGenome&DevelopmentalEngineering

SleepͲawakecyclesinCNS“100%ESmice”“Quantitative”or“Qualitative”Oscillation?

HowSleepͲwakeHistoryis
RecordedinCNS?

EstablishmentofF0Phenotyping
throughNonͲinvasiveAnalysis

VerificationoftheIdentifiedDiseaseͲ
relatedGenesfromHumanGenome
AnalysisbyModelAnimals

TowardmultiͲscaleunderstandingofbiologicalsystems,weareplanningmultiͲscaleresearch
activitiesbasedondifferentbackgroundssuchasphysics,chemistry,informatics,engineering,
andmedicine,andintercommunicatingbetweenfoundationsandclinics.

Pathology, Immunology and Microbiology

Pathology and Diagnostic Pathology

http://pathol.umin.ac.jp/index_e.htm

We investigate the pathogenesis and pathobiology of diseases,
especially the neoplastic diseases, by means of morphology.
Our goal is to discover new entities and to clarify unknown
pathogenesis of diseases through the interaction with clinicalmedicine.
●

Cancer research
●
●
●
●

●

TET2
DNMT1

EBV

host genome●●

Genome pathology, clinical sequencing
Discovery of molecular target for cancer therapy
Proteome pathology

Next generation diagnostic pathology●●

Tele-pathology, digital pathology
AI and 3D technology

Molecular Pathology

Methylation of host DNA

stomach cell
STAT3

NFB

Virus-derived
microRNA

LMP2A

EBV

Application of molecular pathology to diagnostic pathology●●

Primitive phenotypic tarnsformation
Epstein-Barr virus associated gastric carcinoma
Cancer epigenetics (DNA methylation, microRNA)
Cancer classification for individualized medicine

Infection

みAnti-apoptosis
Cancer cell-derived
microRNAEMTManipulation of
microenvironment

exosomeEBV-associatedgastric carcinoma

http://beta-lab.umin.ac.jp/index.htm

We study signaling mechanisms of the TGF-β family
proteins, and elucidate how they regulate progression ofcancers. Mechanisms of regulation of TGF-β-Smad target
genes will be studied by genome-wide approaches. Basedon these findings, we will develop new strategies for thetreatment of cancer.
Dynamic changes in the transcriptional machinery
regulated by TGF-b● Roes of TGF-b in epithelial-mesenchymal transition(EMT)● Roles of tumor microenvironment - approach byorthotopic transplantation models● Analysis of cancer metastasis by tissue-clearing
methods●

Signaling by TGF-β (left) and TGF-β-mediated EMT of mammry epithelial cells (right)

19

Microbiology

http://www.microbiol.m.u-tokyo.ac.jp/

Our major objective is to elucidate molecular mechanisms
underlying development of gastric carcinoma triggered by
infection with Helicobacter pylori. Based on the results obtained
from these studies, we are also developing new strategies forprevention and treatment of infection/inflammation-associatedcancers, which account for ~ 50% of entire human malignancies.
Structural biological analysis of H. pylori oncoprotein CagA
Intracellular signaling pathways targeted by CagA
● Mouse genetic studies on gastric carcinogenesis● Host genetic factors determining gastric cancer susceptibility● Molecular mechanisms linking inflammation and cancer●●

H. pylori - gastric epithelial cell interaction

Infection Control and Prevention
We are engaged in education of medical staff as well as in daily clinicalacti vities on the prevention of healthcare-associated infection(HAI). Research activities on the pathogenesis of infection with hepatitis
viruses and HIV, in particular, on the mechanism of hepatocarcinogenesis in
HCV infection are also our mission.
Development of preemptive strategies for the control of healthcare-associatedinfection● Development of new methods in infection control and treatment of viral
hepatitis● Molecular pathogenesis of hepatocellular carcinoma in HCV infection● Pathogenesis of progression of HIV infection● Molecular pathogenesis of the mitochondrial disturbances in viral infections● Molecular pathogenesis of hepatitis B viral infection● Host defences to microorganisms● Molecular analysis of innate immunity in microorganism infection● New detection method and pathogenesis of opportunistic cytomegaloviral
infection● Mechanism of multi-drug resistant microorganisms● Molecular epidemiology of Clostridium difficile●

Infection control team rounds

Immunology
We aim to comprehensively understand immune responses byanalyzing molecular mechanisms of the development of immune
cells and the regulation of innate and adaptive immune systems,
and to provide novel strategies for the treatment of immune
diseases. We focus on the molecules and immune cells that
contribute to autoimmune diseases, employing geneticallymodified mice to address their physiological significance in vivo.
Animal models for studying immune cells by genome
engineering technology● Molecular mechanisms of immune cell development● Role of immune tissue microenvironment in immune cell
regulation● Mechanisms and pathogenesis of autoimmune diseases● Regulation of bone metabolism by the immune system● Regulation of immune cells in bone microenvironment●

20

http://www.immunol.m.u-tokyo.ac.jp/english
T cell repertoire selection in the thymus
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720-*-5")0"%".*-26#$%5&'$5(%0%,'((&!"(Randomly generated
immature T cells)

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0+A+B+ '-%+(;%*+)),<=>C

Radiology and Biomedical Engineering

Radiology

http://www.ut-radiology.umin.jp/

We have been performing a variety of research studies in biomedical imaging
and analysis, computer-assisted diagnosis (CAD) and radiation therapy.
●

Diagnostic Radiology
●
●
●

●

Radiation Oncology●●●

MRI analysis of brain morphology, diffusion, function and network
Development and application of CAD systems
Simulation of interventional radiology procedures using 3D printing
Stereotactic irradiation by gamma knife, synergy system and intensity
modulated radiotherapy (IMRT)Clinical and biological studies for the reduction of radiation-induced damage

Nuclear Medicine●●

Functional imaging using radioisotope-labeled tracer technology
Imaging of brain metabolism and aggregated proteins using PET
Representative images analyzed with computerassisted technology

System Physiology
We study biomechanics dealing with mechanical phenomena in
the human body, especially focusing on cellular sensing andmechanisms underlying the responses to mechanical stimuli. The
main theme of our work is to elucidate how vascular endothelial
cells sense hemodynamic forces (i.e., shear stress and cyclic
stretch) generated by blood flow and blood pressure. This would
be of benefit not only for understanding the blood flow-mediatedregulation of vascular functions, angiogenesis and vascularremodeling, but also for the elucidation of clinically important
problems, such as the development of atherosclerosis andcerebral aneurysms.
Mechanosensing and mechanotransduction● Hemodynamic force-induced cellular responses● Hemodynamic force-mediated gene regulation●

http://square.umin.ac.jp/bme/research_Eng.html
Order of lipid phases

Lipid order

Laurdan imaging

Shear stress

Membrane fluidity

DiI imaging
Liquid-ordered stateTwo-photon
microscopy Liquid-disordered state

Ca2+ imaging

ATP release

Membrane protein

StretchCaveolae䞉raft

Ion channels
ATP

FRAP analysis

Membrane lipid

Dimerization
Phosphorylation

Two-photon excitation Cholesterol imaging
fluorescence microscopy
ATP

TM1TM2

Confocal microscopy

䠄D4-GFP䠅

TIRF microscopy
FRET

Fluorescence microscopy
䠄Caveolin䞉Cavin䠅
LC-MS
Flow cytometry
Chemiluminescence imaging

Analysis of mechanosensing molecular mechanisms
in vascular endothelial cells

21Chemical Biology and Molecular Imaging

http://cbmi.m.u-tokyo.ac.jp/

Our research field is so-called chemical biology. One of our main
research interests is to develop novel small molecule-based photofunctional tools for biological and medical research, including
fluorescence probes for detecting various events in living cells andanimals. Recently, we have succeeded to develop fluorescenceprobes for in vivo tumor detection, and they are now applied to realresected human samples by collaborating with many surgeons.
Establishment of rational design strategies for various photofunctional small molecule-based probes● Development of novel fluorescence probes, photosensitizing
probes and caged compounds, and their application to various
living biological samples● In vivo detection and therapy of tumors in model mice and realhuman samples by using rationally designed novel fluorescenceand photosensitizing probes●

Biosystem Construction and Control

http://www.bme.gr.jp/bme_E/

Our research fields include medical engineering technologies
represented by the artificial organs. Especially in the research of theartificial heart, the goat whose heart was replaced with the new typeof the total artificial heart survived for more than three months. To
rescue the life of cardiopulmonary arrest patients, the compact
emergency life support system has been developed. Other thanthese, researchs and developments of bio-compatible materials,
sensors, new diagnostic devices and an implantable artificial kidney
have been performed.
Artificial heart
Emergency life support system● Hybrid technology of biological and artificial materials● New blood pumps● Implantable pressure sensor● Implantable artificial kidney●●

22

Helical flow total artificial heart (HFTAH), hybrid cannula andcompact emergency life support system (ELSS)Neuroscience

Neuropathology
Elucidate the pathomechanism of neuronal degeneration and death in major
neurodegenerative disorders (e.g., Alzheimer disease, Parkinson disease), anddevelop novel strategies for disease-modifying therapies.
Mechanism of Ab production, aggregation and clearance
Pathological function of b-amyloid binding proteins (e.g., CLAC)● Mechanism of aggregation and neurotoxicity of a-synuclein● Pathological function of familial Parkinson disease gene LRRK2● Strategies for development and validation of disease modifying therapies for
Alzheimer disease (J-ADNI Clinical Study)● Mechanism of extracellular release and propagation of tau protein● Pathological function of TDP-43 and FUS in amyotrophic lateral sclerosis●●

Phosphorylated α-synuclein deposited in Lewy
bodies of Parkinson's disease and Lewy body disease

Neurochemistry

http://www.neurochem.m.u-tokyo.ac.jp/
Homepage.html

Our brain is able to recognize and memorize external and internal events asthey occur. A functional neural network further stands out by its capacity to
extract patterns and rules, and to associate them with abstract meaning andaffective valence. What are the local and global spectra of the molecularsignaling events in neurons that underlie such complex information
processing at the systems level? Are these events, in turn, converted into
more profound modifications of the synaptic wiring mechanisms? To addressthese issues, we are currently investigating the chemistry and physiology ofvarious neuronal protein complexes near and at synapses.
Understanding molecular and circuit mechanisms controlling memory andemotional behaviors, through integration of state-of-the-art in vitro and in vivo
neurobiological techniques in molecular optogenetics/imaging, geneticalcircuit tracing, and quantitative and behavioral experiments in combination
with genetically modified mice and gene transfer using viral vectors.
● Optical and molecular investigation (including real-time imaging and opticalmanipulation) of biochemical signaling in single synapse, synapse to nucleus,
and living brain circuits that are involved in activity-dependent modification ofneural circuit function and behavior.
●

A. Single-synapse imaging (left) and frequencynumber response profile (right) of CaMKIIa andcalcineurin
B. Visualization of migrating neurons (green) andradial glial fibers (red) during corticogenesis
C. Novel object recognition task

23

Child Neuropsychiatry
Main diseases of our current research are autism spectrum
disorder (ASD), ADHD, Tourette syndrome and childhood
Obsessive-compulsive disorder (OCD). From the viewpointof development of brain and mind, we are trying toinvestigate pathogenesis of these diseases by integrating
phenomenological, neuropsychological, brain-imaging andgenetic studies. We are also applying this integrative
approach to treatment research for patients with these
diseases.

Comprehensive assessment for adults with ASD

Relationship between ASD, TS, and OCD

Only ASD
25%

Tourette syndrome (TS)ASD with
other mental
disorders
75%

Tics
Persistent deficit insocial communicationand social interaction“Just right” perception

Anxiety disorders

ASD

Stereotypy

Persistency

OC symptoms

OCD

Trait of anxiety in STAIState of anxiety in STAI

75% of adults with ASD werecomorbid with mental
disorders.
Large discrepancy was foundbetween self-rating andobjective assessment aboutanxiety in adults with ASD.
19%

81%
59%

39%

41%
61%

Anxiety disorder or higher than cut-off scores in STAI

Hyperdirect pathway

Cortex＋Striatum

Dopaminergic
GABAergic
Glutamatergic

Non Anxiety disorder or lower than cut-off scores in STAI

Correlation between Obsessive-Compulsive

Indirect
DirectCaudate & Putamen(OC) Symptoms, Tics, and Global Functioning
Epidemiological, behavior phenotype, neuropsychological,
pathway －pathway
D2(－)
D1(＋)
Tic Symptoms
GlobalOC Symptom＋
genetic and treatment study of Tourette syndrome and＋Dimensions(YGTSS total
Functioning
－
tics)
(GAF)
Globus pallidus SN pars compacta
childhood OCD
externa
Aggression
0.318 *
-0.297 *● Brain-imaging study of ASD, ADHD and Tourette syndrome
Sexual/Religious
0.368**-0.225－
SN pars reticulata－
Symmetry
0.356 **
-0.218Subthalamic● Genomic and epigenomic analysis of ASD and Tourette
Thalamus/Ventral tegmentum
Contamination
0.189-0.254†nucleus＋ Globus pallidus interna
syndrome
Hoarding
0.177-0.075Model of Cortico-striatal-thalamic-cortical pathway in TS
Miscellaneous
0.212-0.239†● Development of predictor of pharmacotherapy and parent
training for ADHD
● Effectiveness study of early intervention for autistic preschoolers and group cognitive behavior therapy for adults with ASD● Investigation on clinical evaluation and psychological education for adults with developmental disorders●

Neuropsychiatry

http://npsy.umin.jp/en/

Our department mainly investigates schizophrenia and autistic spectrum
disorder s not only by biological approaches which integrate
neuroimaging, genetic and animal studies, but also by psycho-social
approaches. We also promote the systematic clinical research training
programs and the cooperation with the basic neuroscience research.
Integrated Neuroimaging studies in Schizophrenia Targeting Earlyintervention and Prevention
http://plaza.umin.ac.jp/arms-ut/● Multimodal neuroimaging studies of autistic spectrum disorders● Clinical trials to establish the medical equipment as a clinical test usefulfor the pharmacological treatment of mental disorders●

Multi-modality neuroimaging in neuropsychiatry using a combination of high-resolution MRI, EEG, MEG, NIRS, and PET

Neurology
Our Department is conducting research programs to elucidate
the pathophysiological mechanisms of neurological diseases
including neurodegenerative diseases, immune-mediateddiseases and neuromuscular diseases, and to establish newtherapeutic approaches for these diseases. We are also
providing excellent training programs to become a boardcertified neurologist.

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ŐĞŶĞ
䋮䋮䋮

Molecular Genetics (identification of disease genes anddevelopment of therapeutic approaches)● Molecular pathophysiology of neurological diseases (protein
structures and functions)● Immune-mediated diseases (autoantibodies)● Neurophysiology and cognitive neuroscience (magnetic
stimulation, NIRS, MEG, PET, and fMRI)● Neuropathology of neuromuscular diseases (pathological studies
on biopsy and autopsy materials)● Multicenter-based clinical research●

http://square.umin.ac.jp/neurotky/ŶĞƵƌŽŶĂůĚǇƐĨƵŶĐƚŝŽŶ

ŶĞƵƌŽĚĞŐĞŶĞƌĂƚŝŽŶ

Neurosurgery

http://www.h.u-tokyo.ac.jp/neurosurg/

The 21st century has been designated as "The Century
of the Brain". To lead Japanese surgical neuroscience,
we have devoted our activities to the following:
advanced clinical neurosurgery, neuroscience researchand graduate and postgraduate education.
Skull base surgery in managing benign or malignant
skull base tumors and cerebrovascular disorders● Genetic analysis of cerebrovascular diseases andbenign brain tumors● Functional neurosurgery including epilepsy surgery● Multi-omics analysis of brain tumors (genetic analysis)● Development of new therapeutic strategies
for malignat brain tumors● Development of novel fluorescence probes for brain tumors● Radiogenomics analysis of brain tumors● Cinical study on gamma-knife surgery● Application of brain functional imaging for neurosurgery● Application of VR technology for surgical simulation●

Pre-operative simulation using 3D-fusion images

25

Social Medicine

Preventive Medicine

https://plaza.umin.ac.jp/prm/

Our goal is to discover appropriate intervention points forthe prevention and therapeutics for issues in health careand hygiene, with special focuses on malignant tumors,from the viewpoints of genomic and information
sciences. Based on bioinformatics for such complex ecosystems of wide varieties of cells, such as large-scale
genomic information at single cell resolution and multidimensional histological image information, we are
exploring preventive / therapeutic targets or biomarkers,
and also analyzing their biological significance indiseases.
Comprehensive genomics; to understand cellularinteractome in cancer environments.
Exploration of preventive/therapeutic interventions● Immune repertoire profiling; to clarify individuals' intrinsic /for diseases by genomics & inforamatics
extrinsic immune environments.
● Histopathological image analysis; to contribute to the medical equalization.
● Functional genomics screening; to discover safe natural metabolites with preventive and/or
therapeutic effects.
●

Public Health

http://publichealth.m.u-tokyo.ac.jp/

Public health is the science and art of preventing disease,prolonging life, and promoting health and quality of life
(QOL) through organized community effort. Through studies
in various fields and laboratories, our department aims toadvance research, support policy development, and promote
education toward these ends.
Efficiency and equity issues of health systems
Health manpower policy● Occupational and environmental health● Health services research●●Physician distribution by municipality in Japan

26

Forensic Medicine

http://ut-forensic.jp

We conduct autopsies, and various examinations including histology,
biochemistry, radiology, toxicology, and genetics as usual practices. We also
perform the following research with other institutes and departments
including Education and Research Center of Legal Medicine, Chiba University.
Analysis and pathophysiology of illegal drugs including new psychoactive
substances.
● Application of imaging modalities such as CT, or MRI for death investigation.
● Age and stature estimation and sex determination using CT .
● Mechanical properties of human tissue.
● Diagnosis of drowning.
● Application of relatively new DNA testing
method for practice of forensic medicine●

Forensic autopsy room

CT room

Biomedical Informatics

http://www.m.u-tokyo.ac.jp/medinfo/

The Department of Biomedical Informatics aims to reform medical
systems and make social contribution by applying information
technology to medical and clinical field including hospital
information management. The department develops innovative
methods that are applicable to medical information systems in theboundary area of healthcare and information science, establishes
infrastructures for information environment, and applies knowledge
and technique acquired through these efforts to medical andhealthcare field.
The main keywords of the target domain are medical and clinicalinformation systems, next-generation electronic health record
systems, virtual health care environment, and AI including natural
language processing as well as machine learning.
Automatic Mapping from Clinical Case Dara toDevelopment and application of clinical ontology
Knowledge of Disease Transition
Research for sharing healthcare data among medical institutions
and hospitals, and the application for clinical epidemiology● Extraction of medical knowledge from electronic medical record database using natural language processing● Development of knowledge-driven real time alerting system in clinical practice● R&D of medical artificial Intelligence and mobile healthcare system●●

27

Internal Medicine

Cardiovascular Medicine

https://cardiovasc.m.u-tokyo.ac.jp/

We aim to provide the finest medical care for all cardiovascular diseases, including ischemic heart disease, arrhythmia, valvulardisease, pulmonary hypertension, adult congenital heart disease, and arterial diseases. In particular, we have treated the largest
number of serious heart failure patients in Japan. In collaboration with the Cardiovascular Surgery, we would like to work as thelast bastion against heart failure. Moreover, with ongoing basic research and translational studies, we are developing new
diagnostic modalities and treatments for refractory diseases.
Investigation of disease pathophysiology (severe heart failure, Marfan’s
syndrome, pulmonary hypertension, etc.) and development of novel
therapies● Analysis of genome, epigenome, and transcriptomes in various
cardiovascular diseases● Investigation of pathophysiology of cardiomyopathy using iPS cells● Research on the role of chronic inflammation in the pathogenesis of various
cardiovascular diseases● Research on endothelial dysfunction in various diseases● Development of new integrated databases for clinical information andresearch● Improvement of imaging techniques (echocardiography, MRI, CT, SPECT) for
cardiovascular diseases● Clinical research of severe heart disease, pulmonary hypertension,arrhythmia●

Respiratory Medicine

http://kokyuki.umin.jp/

The number of patients with pulmonary diseases is increasing. At the
Department of Respiratory Medicine, we conduct a wide variety ofbasic and clinical research. We focus on molecular analysis of lungdiseases to develop novel treatment strategies.
Molecular profiling of lung cancer
Discovery of novel prognostic biomarkers in lung cancer● Targeted clinical sequencing of lung cancer specimens● Clinical research using the lung cancer database● Molecular analysis of COPD using animal models● Molecular analysis of asthma● Molecular analysis of pulmonary fibrosis using animal models● Clinical epidemiology using the DPC database● Case reports●●

Expression of ASCL1 and immune-related genes in lung adenocarcinoma

28

Gastroenterology

http://gastro.m.u-tokyo.ac.jp/med/home.html

Our Department of Gastroenterology is one of the top institutions in the world in
the treatment of hepatocellular carcinoma by unique ablation(RFA) andgastrointestinal/pancreatobiliary cancer/stone by endoscopic manipulation(ESD&ERCP). The goal of our department is to accurately diagnose and give thebest available treatment to these patients, and to this end, we are performing awide variety of basic as well as clinical research.
Development of better therapeutic strategy for hepatitis B and C
Elucidation of hepatocarcinogenesis mechanism in viral hepatitis● Development of a better therapeutic modality for hepatocellular carcinoma& metastatic liver tumor● Elucidation of gastric injury mechanisms by Helicobacter pylori● Elucidation of stem cell and carcinogenic mechanism of gastrointestinal cancer● Development of therapeutic strategy for advanced pancreatobiliary cancer● Development of a better endoscopic therapeutic modality for pancreatobiliary cancer/stone● Development of better diagnostic & therapeutic strategy for chronic pancreatitis● Development of an endoscopic en bloc resection method for early gastric, esophageal and colonic cancer● Elucidation of the mechanisms of metabolism-associated liver diseases● Development of better diagnostic & therapeutic strategy for small intestinal diseases●●

Nephrology / Endocrinology

http://www.todai-jinnai.com/

We are investigating the pathophysiology of renal and endocrine
disorders for the development of innovative diagnostic and therapeutic
tools.
Analysis of pathophysiology and development of therapy of chronic kidneydisease● Abnormal oxygen metabolism of kidney disease● Epigenetic changes in CKD● Development of biomarkers and therapy of acute kidney injury● Renal physiology and morphology● G protein signaling in health and disease● Clinical and basic investigation of bone and mineral disorders● Pathophysiology of hypertension●

Nutrition and Metabolism
We are investigating to reveal the molecular mechanisms underlying the development of metabolic diseases (diabetes
mellitus, lipid metabolic disorders, obesity disease, sarcopenia, metabolic syndrome and atherosclerosis) using
interdisciplinary approaches and state-of-the-art technology including genetically engineered model animals, iPS cells,
omics analyses (epigenome, metabolome etc), human genetics, clinical epidemiology and bioinformatics. Our major goal
is to develop mechanism-based fundamental treatment and prevention strategies for the metabolic diseases.
●

Elucidation of molecular mechanism of insulin resistance linked to obesity,

sarcopenia and development of novel treatment focusing on AdipoR,
myokines etc

Genetic engineering
Development ofbest-in-class medicine
Animal model
Based on 3-D structure

Functional analyses by
iPS and genome editing

Epigenetic analysis of the mechanisms of metabolic control and their disruption
Liver
Brain
in type 2 diabetes and obesity
IoT,AI, ICT● Elucidation of the molecular mechanism of metabolic diseases andSpleenGutdevelopment of novel treatment using iPS cells
Immunemicrobiota
Bioinformatics● Molecular mechanism of insulin signal transduction● Molecular mechanism of insulin secretory defect in type 2 diabetes
Vasculature
Adipocytes
Intestine● Genetic susceptibility and risk factors of type 2 diabetes
Human genetics● Using IoT, AI, development of accurate diagnostis, prevention, treatment
algorithm for type 2 diabetes
MuscleTranscriptome
Metabolome● Molecular mechanism of adipogenesis and obesity
Genome Epigenome
GWAS● Transcriptional regulation of lipid metabolism
Integrated analyses● Molecular mechanism of atherosclerosis● Mouse genetic models of diabetes, lipid metabolism disorder and atherosclerosis●

29

Hematology and Oncology

http://www.u-tokyo-hemat.com/

We investigate the pathogenesis, diagnostic methods, and novel therapeutics of hematological diseases by thecomprehensive use of research technologies in molecular biology, cellular biology, developmental engineering, andgenomic science. Studies about transcriptional regulation and signal transduction in hematopoiesis and analyses ofregulation of hematopoietic stem cells are promoted. We
also implement basic and clinical studies based on
genomics, regenerative medicine, immunotherapy andtransplantation medicine, which aim at application totherapeutic strategies.
Mechanisms in the regulation of self renewal anddifferentiation in hematopoietic stem cells● Comprehensive genomic and epigenetic analysis ofhematological malignancies● Elucidation of the molecular mechanisms underlying thepathogenesis of leukemia● Development and analysis of mouse models of
leukemogenesis● Regenerative medicine and pathogenesis study based onhuman iPS cell technology● Adoptive immunotherapy with T cells engineered withchimeric antigen receptor or T cell receptor for cancer●

Allergy and Rheumatology
The principal aim of our department is to provide the best clinicalcare and support to the patients with rheumatic diseases, such as
rheumatoid arthritis, systemic lupus erythematosus, idiopathic
inflammatory myositis, systemic sclerosis, and vasculitis. We
perform both basic and clinical research to translate laboratory
findings into novel diagnostic and therapeutic approach bycombining genetics, transcriptome informatics and immunology.
We think translational research based on human immunology
and diseases is the key to well understand and overcome
rheumatic disease.

Functional genomic/systemic immunological approachin Department of Allergy and Rheumatology
IMMUNEXT (Immune cell expression integrated)database
Transcriptome of more than 20 cell subsets

RA

SLE

Vasculitis

D8・Whole genome sequence CD25
Treg
・TranscriptomeMem
NeutroCD8・epigenome（ATAC-seq）・chromatin structure(Hi-C)・miRNA
Functional analysis
・metabolome
・mice model・iPS cell

AOSD
BehcetInfectious Diseases
We are investigating both clinical and basic aspects in infectious diseases, inparticular, on HIV infection and hepatitis viral infections, the latter of which is
the major cause of liver diseae worldwide. Our research topics cover the wide
areas in microbiology, immunology and pathobilology of infectious diseases,
including viral and bacterial infections.
Clinical studies of HIV infection
Treatment and prevention of viral hepatitis● Molecular pathogenesis of hepatocellular carcinoma in HCV infection● Pathogenesis of extrahepatic manifestations and its control in HCV infection● Molecular pathogenesis of hepatocellular carcinoma in HBV infection● Molecular pathogenesis of hepatitis B viral infection● Pathogenesis of influenza viral infection● Molecular epidemiology and pathogenesis of bacterial infection● Host defenses to microorganisms● Mechanism of multi-drug resistant microorganisms
●

30

DN
B

Mem
CD4+

●

●

LAG3+
Treg

Sw+
Mem
B
SwMem
B

Th2

ＩＩM
SSc

Th1

Genome/transcriptome analysis of immunological diseases
HC
Disease classification and diagnosis with genome/transcriptomeof immunological diseases● Comprehensive analysis of miRNA in immunological diseases● Identification of molecular pathway related to prognosis in treatment-resistant RA● Identification of molecular pathway related to organ damage in SLE● Molecular analysis using conditional knockout mice
● Functional analysis of immunological disease-associated variant using disease-specific iPS cells●

CD14CD16Mono

CD14+C
D16+M
ono

Naïve
CD4+

Naive
B

Th17
TFH

mDC
NaiveC
+

+

+

PB
pDC
NK

Stress Sciences and Psychosomatic Medicine

http://psmut.umin.ac.jp/

The targets of our laboratory include stress-related diseases such as primaryheadaches and lifestyle-related diseases, eating disorders and malignancies.
The goals of our work are to determine the mechanisms of these conditions,to develop objective markers for diagnosis and severity, and to discover new
treatment approaches using ecological momentary assessment (EMA),
biochemical assessment of eating-related molecules, and physiologicalassessment of autonomic nervous function.
We are using ecological momentary assessment (EMA) techniques tocollect and evaluate subjective and objective data including physicalactivity and autonomic nervous function in natural settings in stress-relateddiseases. We are also developing new treatments using these methods.
● Investigation into the pathophysiology, psychopathology andneurobehavioral basis of stress-related diseases by use of ecologicalmomentary assessment methods● Using heart rate and blood pressure variability, we are investigating
autonomic nervous function in eating disorders. This work uses non-linear
analyses such as fractal analysis, as well as linear analysis.
● We have developed an egogram questionnaire, which we refer to as the
TEG.
●

Clinical Laboratory Medicine

http://lab-tky.umin.ac.jp/

The main goal of our research projects, described below, is the development of new and useful laboratory tests, andelucidation of pathophysiology of diseases through laboratory tests.
(Patho)physiological roles of lysophospholipid mediators, and its
application to laboratory medicine● Platelet biology, Laboratory diagnosis of heparin-induced
thrombocytopenia● Discovery of biomarkers for liver diseases● Genetic testing● Clinical introduction of the assay of oxidized/reduced albumin● Cell surface analysis and quantification of cell surface antigens
usingflow cytometry● Analysis of ventricular functions using echocardiography● Relationship between the respiratory function and various
pathophysiological conditions● Magnetoencephalographic (MEG) study on neural mechanisms foraudiovisual integration● Machine-learning approach for medical diagnosis●

Transfusion Medicine

Analysis of Lysophospholipids

http://square.umin.ac.jp/traf-tky/

The Department of Transfusion Medicine aims the achievement ofsafe and appropriate transfusion practice in the hospital, and forthis purpose, controls, tests and supplies all blood products fortransfusion.
The research fields include:
Detection of red cells/ leukocytes/platelets antigens/antibodies
Development of new anti-angiogenic strategies for thetreatment of solid tumors● Investigation on the pathophysiology of the immunologicaladverse effects of transfusion● Clinical study for the safety of autologous blood donation●●

31

Reproductive, Developmental andAging Sciences

Reproductive Endocrinology

http://www.h.u-tokyo.ac.jp/patient/depts/a_joseika01/index.html

We manage women's reproductive health comprehensively throughout
their respective life stages (adolescence, reproductive ages, menopause,and post-menopause). We also aim to develop advanced reproductive
techniques, which could be practiced with higher success rates andimproved safety, based on experimental and clinical research.
Establishment of effective and low-risk treatment for infertility
Development of assisted reproductive technology● Understanding of interaction between the endometrium and embryo
during the implantation period● Study of pathophysiology of endometriosis / adenomyosis● Understanding of local regulation of folliculogenesis● Technical development of advanced endoscopic / minimally invasive
surgery● Development of hormone replacement therapy for perimenopausal /postmenopausal women● Health care for women● Development of oncofertility●●

Gynecologic Oncology

ICSI (intracytoplasmic sperm injection)

http://www.h.u-tokyo.ac.jp/patient/depts/a_joseika01/index.html

Our basic research focuses on genetic and epigenetic analysis on
gynecologic cancer for developing new diagnostic system and cancer
treatment.
Clinically, we are investigating intensive surgical management, as well as
less invasive ( laparoscopic surgery, robot-assisted surgery ) surgery ingynecologic malignancies.
Intensive surgery for advanced or recurrent tumors and minimally invasive
surgery for selected patients● Identification of molecular-targeted therapies and immunotherapies on basisof genome and epigenome wide analyses● Development of novel therapeutics targeting DNA repair pathway● Development of new medical system for gynecologic cancer treatment anddiagnosis using AI technology●

32

After irradiation, SIRT1 are recruited to γH2AX focus.

Perinatal Medicine

http://www.h.u-tokyo.ac.jp/patient/depts/a_joseika03/index.html#ninpu

The researches are on going for development of precise prenatal
diagnosis on the fetal status using ultrasonography and for better
understanding on pathology of perinatal diseases. We are also focusing
on the immunological aspects and inflammation in patho- physiology ofpregnancy. Our goal is to develop the therapy and prevention methods
for habitual abortion, pregnancy induced hypertension, preterm labor,
and cerebral palsy.
Prenatal diagnosis of abnormal fetuses using three dimensional
ultrasonography● Management of recurrent pregnancy loss
● Management of complicated pregnancy● Management of preterm labor● Prevention of cerebral palsy of the newborn● Development of novel therapy for hypertensive disorders of pregnancy.
●

Three dimensional ultrasonography of fetus

Molecular and Cellular Reproductive Medicine
We investigate the molecular mechanisms of reproductive functions
using the knowledge and techniques of molecular and cellularbiology and genetics.
Our studies are focusing on the pathophysiological mechanism of sex
steroid hormones to elucidate how these hormones effect on
reproductive phenomena including embryogenesis, spermatogenesis
and fetal development, and on the prenatal genetic diagnosis.
Effect of sex steroid hormones on reproductive medicine
Molecular mechanisms of embryogenesis● Analysis of implantation mechanism● Analysis of intrauterine fetal development● Prenatal diagnosis using molecular genetics●●

Molecular mechanisms of sex steroids

Pediatrics / Developmental Pediatrics

http://square.umin.ac.jp/ped/

We are studying all aspects concerning the health of infants, children and adolescents.
We have achieved very important contributions to clarify the molecular pathogenesis of pediatric disorders.
Molecular diagnosis, analysis and collaborative treatment of pediatric renal diseases
Molecular diagnosis and analyses of hematological malignancies and solid tumors● Multi‐institutional comparative clinical studies on leukemia and solid tumors● Molecular analysis and diagnosis and collaborative treatment of
endocrine/metabolic diseases and diabetes● Diagnosis, molecular analysis and collaborative treatment of congenital
heart diseases● Molecular mechanism of Neonatal immune tolerance● Comprehensive analysis of biomarkers in neonatal diseases● Microbiome and immune function in neonates● Immunity of neonates born to mothers with systemic autoimmune
diseases● Neurocognitive effects of intrauterine infection and environmental toxins● Diagnosis and comprehensive treatment of neuromuscular disorders● Molecular diagnosis and treatment of mitochondrial disorders● Early intervention of developmental disorders● Patho-physiological analysis by digital data in pediatric critical care
● Protective respiratory care by trans-pulmonary pressure in children● Development of educational program of transitional care●●

33

Pediatric Surgery
Pediatric surgical diseases have great variety. In our department allkinds of pediatric surgical conditions are treated, and in these fetal
and neonatal surgical care is our main interest. We also treat many
pediatric patients using minimally invasive surgeries such as
laparoscopy and thoracoscopy.
Fetal surgery and treatment
Pediatric minimally invasive surgery● Pediatric robotic surgery● Biliary atresia and biliary dilatation: their treatment and long-term
prognosis● The treatment by regenerative medicine of air way malacia andstenosis● Development of pediatric surgical models● Association between pediatric surgical diseases and intestinal
microbiota● Assessment of pediatric surgical procedures using nation-wide data●●

EXIT(ex utero intrapartum treatment):Tracheostomy on a fetus
with laryngeal atresia

Pediatric Oncology
Division of Hematology/ Oncology is one of the world’s
premier research and treatment unit for childhood cancer. We
have tried to translate laboratory discoveries into new
options for children with tough-totreat cancers. Under thesupervision of our physicians, our patients receive care at aworld-class medical center along with the chance toparticipate in clinical trials at the cutting edge of medical
science today. To continue to foster advancement in thesefields into the future, the division also focuses on biologicalresearch about pediatric cancers.
Genetic analysis and investigations for prognostic factors inneuroblastoma● Tumorigenesis of germ cell tumors● Genetic and epigenetic analyses of rhabdomyosarcoma● Comprehensive genetic analysis of hepatoblastoma● Studies on pathogenesis and diagnosis of acutelymphoblastic leukemia● Multi-institutional joint studies on leukemia and solid tumors●

Geriatric Medicine

http://www.h.u-tokyo.ac.jp/patient/depts/rounenbyou/index.html

The department of Geriatric Medicine, established in 1962, is the firstdepartment of Geriatric Medicine in Japan. The staff physicians arehighly trained and experienced in managing complex cares.
Comprehensive cares including assessment and treatment of chronic
diseases and geriatric conditions are provided to ensure quality of lifeand health in elderly patients. Our research interests are as follows:
Molecular mechanisms of vascular calcification
Molecular mechanisms of Sarcopenia● Inhibition of cognitive decline using antihypertensive drugs● Cares and burden of family caregivers of patients with dementia● Risk factors for adverse drug events● Association between sex hormone and geriatric disease● Novel gene responsible for locomotive syndrome, including osteoporosis● Molecular mechanisms of vascular injury in sleep apnea syndrome● Polypharmacy and frailty●●

34

Novel SPI1 fusion genes in T-ALL and functional impact

Surgical Sciences

Thoracic Surgery

http://cts.m.u-Tokyo.ac.jp

We specialize in surgical therapeutics, clinical and basic oncology formalignant neoplasms of the chest, such as primary lung cancer,
pulmonary metastases, and mediastinal tumors. We also study
immunotherapies for patients with postoperative recurrence of lungcancer or those with refractory malignant neoplasms. We started clinicallung transplantation program along with basic research since theUniversity of Tokyo Hospital has become a certified hospital for lungtransplantation in March 2014.
Surgical therapeutics for malignant neoplasms of the chest
Clinical and basic oncology of lung cancer● Clinical and biological studies on thymic neoplasms● Immunotherapy for lung neoplasms● Clinical and basic studies on lung transplantation●●

Cardiovascular Surgery

http://cts.m.u-tokyo.ac.jp/cardiac-surgery

We are leading in Japan by annual surgery case volume of 400. New
knowledge and techniques are actively applied clinically. Many clinicalresearch projects are going on along with routine clinical activities. Ourlaboratories have been also carrying out a large variety of basic research.
●

Clinical research
●
●
●
●
●

●

Improvement of long-term results of heart transplantation
ventricular assist device for end-stage heart failure
valve plasty and valve-sparing operation
Minimally invasive surgery
Treatment of complex congenital heart disease

Basic and experimental research●●●

Development of new control system for ventricular assist device
Development of myocardial regenerative therapy
Development of a new suture device under endoscopic environment

Ventricular assist devices clinically available in Japan35

Gastrointestinal Surgery

http://todai3ge.umin.jp/

Our goal is to cure the cancer patients by much better surgery. The development of better surgical methods have the highest
priority. Better surgery means radicality of the cancer, minimal invasiveness, and good QOL after surgery. Recently, robot assistedtransmediastinal (non-transthoracic) radical esophagectomy has been developed, which shows less postoperative pulmonary
complications and better QOL after surgery compared with conventional esophagectomy.
●

Cure by much better surgery
●
●

●

●

Robot assisted transmediastinal esophagectomy for esophageal cancer
Laparoscopic endoscopic cooperative surgery (LECS) for gastric andduodeneal tumor, non-exposed endoscopic wall-inversion surgery (NEWS)for gastric tumor
Laparoscopic gastrectomy for function preserving (proximal, distal andpylorus preserving gastrectomy)

conventional

Research for carcinogenesis, progression, diagnosis and treatment
●
●
●
●
●
●

Inflammation and gastrointestinal carcinogenesis
Activatable fluorescence imaging probe for esophageal and gastric cancer
Oncolytic viral therapy for esophageal cancer
Genetics and epigenetics for esophageal and gastric cancer
Early detection of gastrointestinal cancer by new biomarkers
Immunotherapy based on intratumoral immune response in gastric cancer

Hepatobiliary Pancreatic Surgery

transmediastinal (non-transthoracic)

http://www.u-tokyo-hbp-transplant-surgery.jp/

We perfom nearly 150 hepatectomies in patients with hepatobiliary
malignancies and nearly 90 pancreatectomies in patients with pancreatic
neoplasms every year. The first priority is put on the safety of the patients
undergoing surgery. In order to improve the surgical outcome for hepatobiliary-pancreatic malignancies, we conduct wide areas of research such as
analysis of prognostic factors for liver malignancies, evaluation of liver
hemodynamics using ultrasonography, liver ischemia/reperfusion injury, andliver regeneration.

ICGfluorescent imaging for detecting tumors
Vascular reconstraction using
criopreserved vein grafts

The analysis of genetic abnormalities in hepatocellular carcinoma
Development of new methods for the evaluation of liver functional reserve● The evaluation of hemodynamics in the congested liver using ultrasonography● Navigation system during liver surgery● Study of intraoperative diagnosis (contrast-enhanced ultrasound, ICG fluorescent imaging,and elastography)● Study of intraoperative diagnosis (enhanced ultrasound and ICG fluorescent imaging)● Clinical trials concerning perioperative chemotherapy in hepatic resection forcolorectal liver metastasis● RCT to evaluate the effects of surgical resection and RFA for HCC (SURF trial) Investigationof adjuvant immunotherapies after surgery for pancreato-biliary malignant tumors● Vascular reconstraction using criopreserved vein grafts Evaluation of the anti-adhesionmaterials●●

Urology

Preoperative 3D imaging of
the liver constructed bysimulation software

http://square.umin.ac.jp/UT-urology/

We perform more than 1,500 urological surgeries every year, including nephrectomy, cystectomy and prostatectomy, withincreasing trend of laparoscopic maneuvers. Robotic surgery was
R subunit(C subunit)
introduced in 2011. Surgical or non-surgical means are employed for
non-cancer disease including chronic renal failure, urinary
dysfunction, urinary incontinence and interstitial cystitis. With regard
to basic research and treatment, genome analysis, dendritic cell
PRKACA（L260R）：34/65 cases（52.3%）
therapy, viral therapy and Botulinum toxin injection are now under
PRKACAHEK293T
L206
C subunit
extensive investigation.
Total cell lysate
●
●
●
●
●
●
●
●
●

Genome analysis of Corticotropin-independent Cushing’s syndrome(Fig.1)
Virus therapy for prostate cancer
Genome analysis of renal cancer, renal pelvic cancer, ureteral cancer andtesticular cancer
Bladder cancer therapy with a vaccine against NY antibody
Dendritic cell therapy for metastatic renal cancer and bladder cancer
Hydrodistention therapy for interstitial cystitis
Artificial urinary sphincter for male urinary incontinence
Robot-assisted laparoscopic radical prostatectomy
Robot-assisted laparoscopic partial nephrectomy
Robot-assisted laparoscopic radical cystectomy

36

Mock WT Mut

Anti HA
Anti PRKACA
Anti PRKAR1A

6

P=6.61×10-3

Relative kinase activity●

NS

P=0.047

4

2

IP: *anti-HA
Anti PRKACA
Anti PRKAR1A*PRKACA is tagged with HA

Forskolin + ―Mock0+ ― + ―WT

Mut

cAMP induction by forskolin treatment

Fig.1 The L206R mutation in PRKACA, which was found in >50% of Corticotropinindependent Cushing’s syndrome, has cAMP-independent activation of cAMP-dependent
protein kinase (protein kinase A).

http://www.u-tokyo-hbp-transplant-surgery.jp/

Artificial Organ and Transplantation Division

609 living donor liver transplantation and 28 deceased donor livertransplantation until Dec. 2018. The 5-year survival rate for adult case was 85%,
which is significantly superior to that of the national data (73%).
Surgical technique of liver transplantation: including
right lateral sector graft, APOLT(Auxillary partial
orthotopic liver transplantation)● Hepatic vein reconstraction using criopreserved vein
grafts● Identification of veno-occlusive resions using ICG
fluorescence imaging● Antiviral treatment for hepatitic C virus infection after
liver transplantation● Validity and feasibility of transient elastography for thetransplanted liver● New-onset daibetes mellitus developing in adult living
donor liver transplant recipient● Diagnosis and treatment for acute rejection● Diagnosis and treatment for postoperative infection●

Overall survivals after living donor liver trasnplantation

Hepatic vein reconstraction using
criopreserved vein grafts
3D images of the liver graftby liver simulation software

http://all-1su.umin.jp/

Surgical Oncology
We have performed basic and clinical research mainly on colorectal cancer
and inflammatory bowel disease. In basic research, we are studying
biological phenomenon from various point of view such as carcinogenesis,
cancer metastasis, and immunology. In clinical study, we are trying to
identify the best way to treat each patient with the least surgical stress byminimally invasive surgery such as laparoscopic surgery and robotic surgery(da Vinci), and preoperative chemoradiation therapy for rectal cancer.
Robot assisted surgery (da Vinci robotic surgery)Radiosensitivity and chemosensitivity of cancer● Characterization of tumor vasculature and its
therapeutic application● Surveillance of ulcerative colitis● Carcinogenesis in ulcerative colitis● Cancer and autophagy● Development of chemoradioimmunotherapy● Genetic analysis of poorly differentiated colorectal
cancer● Intraperitoneal chemotherapy for peritoneal
carcinomatosis●●

Fig.1 Prediction ofchemoradiosensitivity in rectal
cancer by DNA microarray

Fig.2 Targeted vs random
biopsies for surveillance ofulcerative colitis-associatedcancerVascular Surgery

http://all-1su.umin.jp/

We have a great deal of experience in treating patients with various
vascular diseases, and we have performed much research on
atherosclerosis, angiogenesis and vascular regeneration. Based on
the research results, we are trying to identify the best way to treat
each patient with the least surgical stress.
Development of a novel method to diagnose and treat thevasculardiseases.
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Vascular regeneration therapy for atherosclerotic obliteransDevelopment of aortic aneurysm model and simulation
Gene analysis of peripheral arterial disease
Visualization of the atherosclerotic lesions with fluorescent probe
Navigation system for less invasive vascular surgery
Analysis of intermittent claudication with dynamic and mechanicalmodel
Dynamic and genetic mechanism of aortic aneurysm expansion
Development of the new prosthesis with small diameter
Hemodynamic analysis of aortic wall after endovascular aneurysm
repairDrug delivery system for aortic aneurysm and peripheral arterial
disease37

Breast and Endocrine Surgery

http://todai3ge.umin.jp/

Clinical activities in the department of breast and endocrine surgery widely range from diagnosis to surgical treatment forbreast cancer, thyroid cancer, and benign tumors of breast, thyroid, and parathyroid. We also place importance on medical
genetics including hereditary breast and ovarian cancer syndrome (HBOC) as well as precision medicine based on cancer
genome information. Our goal and motivation of basic
research are to eradicate metastatic breast cancer inwhich complete cure has yet to be realized.
BRCAness in triple negative breast cancer
Use of droplet digital PCR for quantitative andautomatic analysis of the HER2 status● Detection of the PIK3CA mutation in circulatingtumor DNA in early-stage breast cancer● Impact of CDK4/6 inhibitor palbociclib on activinSMAD2 signaling in estrogen receptor-positive breast
cancer● Stem-like cells of breast cancer● Epigenetic change which is critical for carcinogenesisof breast cancer●●

Palbociclib decreases Ser255 phosphorylation of SMAD2 in T47D breast cancer cells

Dermatology

http://www.h.u-tokyo.ac.jp/der/Our department actively performs the following cutting-edge, multifaceted
research projects that will be put into clinical practice in the future.
Molecular mechanisms of immunological abnormalities and skin and lungfibrosis in scleroderma● Development of novel therapies to scleroderma, including B cell depletion
therapy● Relative contribution of various cell adhesion molecules and chemokines toinflammatory conditions● Identification of novel autoantibodies and their clinical significance inconnective tissue diseases● New roles of B lymphocytes, especially regulatory roles, in inflammatory
disorders● Immunological abnormalities of atopic dermatitis● Pivotal roles of Fli1 in systemic sclerosis● Roles of chemokines in cutaneous lymphoma● Roles of lipid enzymes and receptors in immune-mediated skin diseases●

Skin fibrosis induced by bleomycin(left) is inhibited in
CD19-deficient mice(right)

Plastic and Reconstructive Surgery
We aim to develop innovative therapeutic interventions for themorbidities associated with plastic and reconstructive surgery. With avariety of state-of-the-art approaches such as gene therapy andmicrovascular surgery, we continuously work on the reconstruction ofskin, fat, muscle and nerve to fight against the intractable diseases.
●

Basic Research
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Development of gene therapies for the intractable diseases in plastic
surgery
Realization of the innovative therapies for cutaneous ulcers via direct
cellular reprogramming
Development of the method for perfect tissue regeneration via tissueembryonization.
Elucidation of pathology of vascular anomalies.
Development of new therapeutic intervention for alopecia

Clinical Research
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38

Aiming at perfect tissue regeneration through tissueembryonization

Development of a novel reconstruction method for facial nerve palsy and its optimization
Standardization of reconstruction method for eye closure in patients with facial nerve palsy by evaluation of blink function
Evaluation of effectiveness of lymphatico venous anastomosis in early stages of lymphedema
Research on dysphagia after tongue reconstruction after cancer resection
Development of tissue perfusion monitoring system using flexible electronic devices

Oral and Maxillofacial Surgery

http://plaza.umin.ac.jp/~oralsurg/

Our laboratory has been performing a wide range of clinically oriented
research in oral-maxillofacial disorders such as congenital diseases, jaw
deformities and tumors in the oral region. Cartilage and bone regeneration
using tissue engineering techniques is our main field of research.
●

Clinical research:

Treatment of facial deformities and malocclusion in patients with cleft lip/palate
Research on facial growth in patients with craniofacial anomalies
Reconstruction of oral and maxillofacial area by custom-made artificial bone (CTbone) (clinical trial) Transplantation of implant-type tissue-engineered cartilage
for cleft lip-nose patients (clinical study) Management of occlusion in patientswith fibrodysplasia ossificans progressiva (FOP) QOL study of oral health caresystem in preoperative cancer patients Clinical study of antifungal susceptibility
in patients with oral candidiasis

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Basic and experimental research:

Regeneration of bone and cartilage with tissue-engineering approach Development of intelligent artificial bone with the ability ofbone induction Development of micro-tetrapod bone implant Molecular biology of cartilage repair and its application to cartilage
regenerative medicine Cartilage regenerative medicine using iPS cells Development of novel scaffolds for cartilage and boneregeneration In vivo evaluation of tissue-engineered cartilage and bone Study on the control of mesenchymal cell differentiation
Elucidation of epigenetic abnormalities in oral cancers and oral premalignant lesions Elucidation of sphingosine-1-phosphate signaling
and its role in multistage oral cancer Functional analysis of microRNAs in human dental pulp stem cells

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Orthopaedic Surgery

http://www.u-tokyo-ortho.jp/

Our department was established in 1906 as the first department oforthopaedic surgery in Japan. Since then our efforts have been dedicated toresponding to the needs of patients for orthopaedic care and to related
research. Our department seeks to elucidate the molecular and genetic
backgrounds of bone and cartilage disorders in order to develop
groundbreaking treatments for these conditions. At the same time, we areattempting to establish various clinical devices.
Systemic and comprehensive study for osteoarthritis
Bone, cartilage and nerve regeneration
Surgical navigation system● Regulation of anabolic and catabolic bone metabolism by cytokines● Molecular mechanism of age-related bone loss
● Molecular mechanism of osteoclast differentiation and apoptosis (RANKL-RANK, INF, Src)
● Gene therapy to control pathological bone destruction (arthritic bone resorption and arthritic joint destruction)using adenovirus vectors● Surgical navigation system with a three-dimensional display and navigation robot● Long-life artificial joint by construction of a super-durable lubricious interface of MPC●●

Ophthalmology
Our department applies cutting-edge technologies and knowledge todiagnosis and treatment of eye diseases. We conduct basic researches
involving multi-faculties with molecular biological, immunological, andpharmacological techniques, and clinical studies with epidemiology andbiostatistics.

https://www.todaiganka.jp/

Surgery techniques
Neuronal Cell Death

Development and evaluation of new drug therapies and surgical
techniques on glaucoma, or retinal, corneal, and uveal diseases.
● Development of diagnosis and treatment in glaucoma with functional and
OCT images
structural analysis.
● Study on mechanisms for maintaining intraocular pressure, anddevelopment of new drugs using clinical samples of glaucoma eyes andSurgery Training System
genetically modified animals.
ＴＧＦＢＩ gene
● Further research in the mechanisms of neuronal death in retinal neurons
and glial cells, and exploration of useful neuroprotective agents.
● Development and application of surgery training systems with bionic eyes.
● Improvements in corneal regeneration therapy and development of new therapies in hereditary corneal diseases.
● Study on corneal mechanisms to maintain clarity.
● Research on refractory uveitis and intraocular lymphoma.
● Comprehensive studies on multimodal imaging of structures and functions of macular diseases.
●

Human TGFBI gene39

Otolaryngology and Head and Neck Surgery

http://utokyo-ent.org/

Our research is composed of both clinical and basic research. Clinical research is conductedby specialized clinics in the hospital, which experience ear diseases and hearing disorders
from neonates to adulthood, head and neck cancer, paranasal diseases, olfactory anddisorders, vertigo and balance disorders and voice and swallowing disorders. Basic andexperimental research into molecular biology, electrophysiology and morphology isconducted in our department's laboratories.
●

Clinical researchCochlear implantation in deaf children and their development of hearing, speech and language
Surgical correction of congenial microtia and atresia and postoperative radical ears to improve
hearing
Quality of life in patients with head and neck cancer to restore speech and swallowing function
Vestibular research on the oculomotor and balance system and myogenic potential
Vestibular rehabilitation by electric stimulation
Survey of eosinophilic sinusitis and refractory allergic rhinitis
Surgical treatment of voice and swallowing disorders
Clinical sequencing for recurrent / metastatic head and neck cancer
Development of fluorescent probes for cancer cell imaging
Basic and experimental research
Molecular biology of the inner ear
Molecular biology of pharyngeal cancer
Molecular biology of differentiation and development of inner ear and olfactory epithelium
Origins of vestibular myogenic potential
Aging and regeneration of olfactory epithelium, pathogenesis of chronic sinusitis and allergic rhinitis
Physiology of vocal cord vibration
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Chochlear implant●●●

Rehabilitation Medicine
Our research purpose is to improve the provision of a unique andcomprehensive rehabilitation service enabling people to develop
their full potential and often returning from being a "patient" to beinga "person". Clinically oriented studies concentrate on elucidation of
the origin of disabilities to cause activity limitation and restriction ofparticipation.
●

Gait analysis●●●

Clinical research on intractable rare diseases
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3-dimensional image analysis with a infrared camera system
Measurements of foot pressures with a computerised pressure sensor
Fibrodysplasia Ossificans Progressiva
Congenital Insensitivity to Plan

Clinical research on congenital limb malformations
Research on the effect of robotic rehabilitation
Gait analysis

Anesthesiology

http://www.anes.umin.ne.jp/

We have seven research groups and their fields include respiration, circulation, pain, immune system and shock.
These are recent major subjects of our research.
Respiratory system: A role of cytokine signaling in acute lung injury;
Exploring optimal ventilatory strategy for respiratory failure● Immune systems: Modification of immune system by anesthesia; Signaltransduction pathway related to apoptosis induced by sepsis or ischemiareperfusion injury● Shock: Investigation of pathophysiology of shock; Effect of new plasma
substitutes on hemorrhagic shock.
● Inflammation: A role of lipid mediators in organ damage mediated byischemia-reperfusion injury of a mouse lower limb.
● Pain: A role of lipid mediators in the formation of hyperalgesia; A role ofspinal microglial cells in the development of inflammation-mediatedneuropathic pain; Mechanism of pruritoceptive and neurogenic Itch;
Cognitive-behavioral therapy on chronic pain.
Anesthesia and monitors● Nervous system: Analysis of electroencephalography during generalanesthesia; Clinical evaluation of neurological sequelae after cardiac surgery; Evaluation of neuroprotective properties ofanesthetics.
● Anesthesia apparatus and other medical equipment: Invention and validation of a new airway device.
● Glucose metabolism: Effect of anesthetics on glucose metabolism in vivo
● Epidemiological survey and outcome study with large administrative database.
●40

Acute Medicine

https://www.tokyodam.com/

We, acute care physicians, have a role to treat the patients with sudden and unexpected illness and injury, and our
specialties are very wide in the settings of prehospital, disaster, ER (emergency room), and critical care. Acute Medicine is
the science of these fields. Main studies of our department are as follows.
Acuity of injury and illness related studies●●

Establishment of conception of "definitive acuity"
Acuity and severity scoring system

Methodology of task switching in the setting of multitask at ER
Improvement of outcome of emergency patients by mobile on-site
physicians team
● Performance indicators of medical control for paramedics● Performance indicators of regional emergency medical service system● Critical care related studies

Research Field of Acute Medicine●●

Relationship between biomarkers and severity of critically illness
Non invasive monitoring technology to predict circulatory shock status

Versatile and durable WEB-based information sharing system for emergency
medical service system and disaster medical response.
● Mass casualty incident and natural disaster medical response related studies
●

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Preh

●

ospit
Disa al care mster
med edicine
icine

●

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Investigation of regional disaster medical risk-resource-ratio (static approach)
Dynamic simulation model of necessity of regional medical resource in MCI and large scale natural disaster

41

Health Sciences and Nursing

Mental Health / Psychiatric Nursing

http://plaza.umin.ac.jp/heart/

Our departments conduct research on mental health and psycho-social
stress and provide education/ training of professionals in related fields
from global perspectives.
●

Mental Health
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Mental health epidemiology
Occupational mental health/Occupational health psychology
Internet-based Cognitive Behavioral Therapy
Perinatal Mental Health
Disaster and mental health
Global mental health

Psychiatric Nursing●●●●

Supporting people living with mental health problems
Wellness self-management in mental health
Recovery for people with mental illness
Peer support

Biostatistics / Epidemiology and Preventive Health Sciences

http://www.epistat.m.u-tokyo.ac.jp/

We are working on methodological researches of biostatistics andtheoretical epidemiology, as well as consulting and supporting the
conduct of epidemiologic/clinical studies. The followings are ourimportant missions: biostatistical education for undergraduate andgraduate students; the support of planning and analysis for clinical trials
conducted in the University of Tokyo Hospital Clinical Research Support
Center; and the support of resource development for academic
biostatisticians.
●

Methodology
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Design and analysis of clinical trials/epidemiologic studies
Statistical analysis of real-world data
Causal inference, missing data analysis and meta-analysis

Collaborative projects
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42

Phase II/III study of gemcitabine and S-1 (GS therapy) as neoadjuvant
chemotherapy for resectable pancreatic cancer
Randomized Evaluation of Aggressive or Moderate Lipid Lowering
Therapy with Pitavastatin in Coronary Artery Disease (REAL-CAD)
Japan Environmental and Children's Study (JECS)

What is a causal effect? Biostatistics provides the means tocausal inference from observed data.

Nursing Administration / Advanced Clinical Nursing

http://nurs-adm.umin.jp/

We aim to develop systems and methodology to bring out the potential ofnursing and healthcare organizations to contribute well-being of not only
patients, but also workers and institutes, and society. With this aim, we try
to elucidate complex organizational phenomena, and to find keys toeffective organizational development, while tackling to develop the
methodology for organizational researches.
Organizational process/management process
Work environment● Methodology for understanding phenomena in nursing
organization●●

Family Nursing
Hand-in-hand with the seismic social changes occurring nationally andworldwide -- including declining birthrates and a growing proportion of elderly
people, vulnerability of regional networks, and movement toward a genderequal society -- the form and function of the family unit are also changing.
Current Japanese society expects not only a client-centered perspective, butalso a perspective of the family as 'client' in nursing research. Within thiscontext, our research focuses especially on child-rearing issues and on caring
for children with illness.
Postnatal depression, difficulties in child rearing, child abuse and neglect
Development of Pediatric QOL Inventory for children with chronic illness and theirparents● Transitional care for children, adolescent and young adult with childhood-onset
chronic diseases and their families● Support for survivors of childhood cancer including caring of their late effects,
special needs education, school reentry and working● Role and expertise of nursing staff in daycare centers● Burden borne by caregivers of children with medical complexity, and their utilizationof respite care services● Care for dying patients and their families (QOL, family function)●●

Community Health Nursing

http://park.itc.u-tokyo.ac.jp/chn/english/index.html

The goal of our department is to continuously maintain and improve thehealth and quality of life of people regardless of their life stages andhealth statuses, by taking advantage of the characteristics of a target
community or population and constructing the system. Also, we cover
the research on skills of public health nurses who are the provider ofcommunity health care.
Construction of community health care system
Community health care for maternal and child health/ adult health/elderly’s health/ mental health● Community health nursing for disaster prevention and recovery● Skills of public health nurses●●

Assessing community’s characteristics for Community Diagnoses

Health education program for elderly people

43Gerontological Home Care and Long-term Care Nursing/
Palliative Care Nursing

http://www.adng.m.u-tokyo.ac.jp

Our research activities are targeted at quality assurance/
improvement of long-term nursing care for clients and their family
members. We also aim at advancing knowledge grounded at
nursing activities in Japan. 1) Developing theoretical frameworks
that guide nursing care by explaining the nature of illness/aging
experience and experience of taking care of others. 2) Developing
quality improvement systems for nursing/healthcare in hospitals,
long-term care facilities, outpatients, and home care.
Quality assurance/improvement of care in the long-term care system
Development of clinically derived theories through case studies andphenomenological approach● Development of a community care system and nursing role
● Development of quality indicators for long-term care
● Development of IT-based nursing care/educational programs●●

Hosted workshops for community-building using a gaming toolMidwifery and Women's Health

http://midwifery.m.u-tokyo.ac.jp/en/

The physical and psychological changes that occur during the perinatal period have a critical influence on women’s lifelong
health. Additionally, this influence extends to their children, families, and communities. Our department specifically focuseson the health of mothers and children in the perinatal period and mainly performs research in the following areas:●

Creating evidence of health guidance during pregnancy●●●

Development of a support system for reliable childbirth
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The effect of pelvic floor muscle exercise program for postpartum body management
Life and sleep among working mothers of infants and toddlers
Support for breastfeeding of working mothers
Intimate partner violence (IPV) and its related factors

Creating evidence of health guidance for neonatal skin care●●●

Midwifery care for positive childbirth experiences
Addressing "Fear of childbirth" and psychosocial factors among pregnant Japanese womenDevelopment of assessment methods of birth canal using transperineal ultrasonography

Development of a support system for women’s health●●

Healthy lifestyle: adequate maternal nutrition, weight management, exercise, physical activity,
sleep, and mental health
The effect of exercise and nutritional advice on health outcomes

Development of an effective skin care intervention to prevent neonatal skin problems
Changes in neonatal skin barrier function and skin resident microflora by skin careInternational collaborative study●●

Development of the strategy for safe delivery in El Salvador
Secondhand smoke exposure during pregnancy and its related factors in Mongolia

Drawing / Shoichi Sakamoto

http://www.rounenkango.m.u-tokyo.ac.jp/
index-e.html

Gerontological Nursing / Wound Care Management
Pressure ulcers and diabetic foot ulcers usually occur in elderly people
due to basic activities of daily living such as walking, sleeping, diet andexcretion. Thus their supports are inevitable for comprehensive woundcare management. Especially, diabetes mellitus, nutrition, and skin careare of importance for wound healing, hence we account for these keys
to develop wound care technologies and devices. Our department
address the new concept of nursing science, ”Bioengineering Nursing”,
in which the basic science will be translated into clinical science throughco-development of new technologies and devices with specializedengineers.
●                   
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  
                        Development and evaluation of wound management technology anddevices
●
●

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44

Elucidation of pathophysiology and its diagnosis technology of wound
Development of technology and devices for wound management andprevention
Evaluation of new technology and devices
Investigation of bioengineering aspect of elderly skin
Exploring of objective parameter of skin status
Development of intervention methodology for improving skin function                                

   
Products developed through bioengineering nursing researchmodel

Health Sciences and Nursing
Health Sociology See Health and Social Behavior(p50)
Health Education See Health and Social Behavior(p50)
Biomedical Ethics See Biomedical Ethics(p51)45International Health

Global Health Policy

http://www.ghp.m.u-tokyo.ac.jp

Our mission is to improve population health by enhancing accountability and improving the evidence base of global (bothdomestic and international) health programs through the provision of the best possible information and rigorous
monitoring and evaluation. The department's members generate knowledge and ideas through their research with highsocial and academic impacts, strengthen technical and leadership skills through educational programs, and enhancenational capacities through collaborative projects, especially in the developing world.
The priority areas of research are:
● Global Burden of Disease (GBD)● Health System Performance Assessment● Domestic Health Policy Reform● Inequality and Inequity in Health● Infectious Disease Modeling● Non-Communicable Diseases● Health Technology Assessment and Health Innovations● Radiation Exposure and Health in Fukushima

Community and Global Health
Our department acts for health and wellbeing of socially vulnerable
people. Health itself is not necessarily our ultimate goal. How can an
individual dream and reach her/his ultimate goal in life by making the bestuse of his/her health? This is more critical. We study and teach how it canbe done in global settings. When any interventions are implemented, we
continue to ask who receive real benefits from them.
Health, nutrition, and development
Health, human rights, and human security● Infectious disease control (malaria, TB, HIV, NTDs, etc.)● Health promotion● Disaster and health● Human resources for health● Maternal, newborn, and child health● Implementation research● Positive deviance approach●●46

http://www.ich.m.u-tokyo.ac.jp/en/index.html

Human Genetics

http://www.humgenet.m.u-tokyo.ac.jp/

Department of Human Genetics is broadly interested in
the human genome diversity, especially in the Asian
populations. Specifically, we are using genomic researchtools including SNP analyses, as well as gene expression
profiling, to better understand the genetic background of
a variety of complex diseases, especially bone and joint
diseases, infectious diseases and sleep disorders.
●Theoretical and experimental analyses on the genetics ofcomplex diseases
●

●

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Development of statistical approaches for susceptibility
gene mapping in complex diseases
Comprehensive genetics of bone and joint diseases
Host susceptibility factors to infectious diseases
Molecular mechanisms of sleep disorders

Analysis on the genome diversity of Asia-Pacific populations
Development of methodologies for the analysis of protein interactions

Developmental Medical Sciences
Founded in 1966 as the Department of Maternal and Child Health, thisdepartment has devoted itself to the research and education on themaintenance and promotion of mothers' and children's health,including studies of infectious diseases, nutritional disorders andcongenital anomalies. At present, the main research activities areexperimental and epidemiological studies on the etiology (genetic andenvironmental factors), pathogenesis, prevention and treatment ofvarious childhood brain disorders (congenital and acquired) that cause
mental and motor disabilities and epilepsy, from the viewpoint ofinternational health science and developmental neuroscience.
●

Studies on developmental brain disorders
●
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Molecular epidemiology of infectious diseases●●●

Acute encephalopathy (brain edema)
Tuberous sclerosis (abnormal signal transduction)
Epilepsy, Rett syndrome (abnormal synaptic function)
Perinatal brain injury (hypoxia, ischemia)
Diarrhea viruses
Herpesviruses

Epidemiology of maternal and child health●●

Malnutrition
Perinatal medicine

Human Ecology

http://www.humeco.m.u-tokyo.ac.jp/en/

The field of human ecology encompasses a wide range of perspectives inan effort to understand human health in relation to adaptation to physicaland social environments. To this end, we use methodologies developed inhuman biology, nutritional sciences, anthropology, demography,
environmental health, and urban ecology. The major topics of our studies
include:Health impact of exposure to heavy metals, air pollution, unhealthy urban
structures, and ecosystem degradation;● The roles of gut microbiota in nutritional adaptation and the evolution ofhuman populations;● Mitigation of the health impacts of aging and depopulation at community/
national scales;● Biological and behavioral explanations of low fertility and fecundity during
the post-demographic transition period;● Interaction among subsistence, nutrition and health; and● Medical anthropology; ecological anthropology.
●

A community in Laos.

Rice terraces in West Java, Indonesia.

47

Biomedical Chemistry
Our major research interests include virulence mechanisms and metabolism
of protozoa, particularly Plasmodium spp. causing malaria and Entamoeba
histolytica causing amebic dysentery. We mainly focus on vesiculartrafficking, phagocytosis, autophagy, proteases, amino acid metabolisms,
RNA maturation, translation, drug development, and organellogenesis. Our
research approaches are very robust, and include biochemistry, molecularand cell biology, live imaging, multi-omics including metabolomics, andreverse genetics. Our present research themes include:
Molecular elucidation of pathogenesis of parasites
Biochemical and biological analyses of metabolism and organelles unique toparasites● Analysis of vesicular traffic, protein secretion, and phagocytosis/trogocytosis
in parasites● Genome wide analysis and comparison of parasite strains● Drug discovery and development against protozoan infections such as
malaria and amebiasis● Elucidation of divergence of RNA maturation and translation●●

Entamoeba histolytica eating human cells

School of Public Health
Biostatistics See Biostatistics / Epidemiology and Preventive Health Sciences(p42)
Health Sociology and Health Education See Health and Social Behavior(p50)48

School of Public HealthSocial and Preventive Epidemiology
Our main research field is preventive epidemiology onlifestyle-related diseases. This department is unique inJapan since our core research field is "nutritional
epidemiology", which epidemiologically examines theroles of diets for disease prevention and control.
Methodological studies on dietary assessments
Nutritional epidemiologic studies on nutrient intakes/
dietary
behaviors and health status● Studies on development of dietary promotion methods
andevaluation of their effectiveness● Establishment of literature database for "epidemiologic
studies on diets and health"● Collaborative studies with clinical trial groups on nutritionrelated diseases●●

Clinical Epidemiology and Health Economics
Through the cooperation with the specialists of
epidemiology, statistics, clinical medicine, and economics,
we implement multidisciplinary studies on clinicalepidemiology, health economics, health technology
assessment and health policy using large healthcare
databases.
Clinical epidemiological studies using the Diagnosis
Procedure Combination database● Health economics and policy studies using thegovernmental statistics● Application of statistical methods for observational
studies● Integration of multiple databases●49

Health Communication
The Department of Health Communication conducts research on the
University hospital Medical Information Network (UMIN) Center related
activities as well as health communication research at various levels.
Main research topics include;● Communication of health information to general public● Patient-provider relationship and communication● Health literacy● Activities related to the UMIN
● Information systems for clinical epidemiologic studies● Security of the information network

Mental Health

http://plaza.umin.ac.jp/heart/

The Department of Mental Health has engaged in education andresearch on a wide range of topics related to mental health, such associal determinants of stress and mental health. The Departmentp r ov i d e s c l a s s e s o f M e n t a l H e a l t h I ( e p i d e m i o l o g y a n dcountermeasures in mental health) and Mental Health II (occupational
mental health).
Community-based mental health epidemiology
Occupational mental health● Internet-based Cognitive Behavioral Therapy● Perinatal Mental Health● Disaster and mental health● Global mental health●●

Health and Social Behavior
The unit follows the legend of former departments of health sociology,
health education, and social gerontology, and extends its academic
endeavor to empirically reveal complex mechanisms between social
structure/relationship and individual health/behavior. Throughinterdisciplinary and global communication with social science andhealth science, the unit aims at exploring research and education onsocial determinants of health, such as;Trans-generational health impact of socioeconomic status
Health impact of retirement and social participation among the elderly● Policy intervention design to alleviate social exclusion● The impact of healthcare systems for health equity● Social experiences of chronically ills and their health●●

50

The UNU-IIGH/UNDESA/the University of Tokyo Expert Meeting on
Mental Well-being, Disability, and Development in Kuala Lumpur,
Malaysia, April 2013

Biomedical Ethics

http://www.ethps.m.u-tokyo.ac.jp/

The Department of Biomedical Ethics conducts both theoreticaland empirical studies in the fields of biomedical ethics, research
ethics and clinical ethics. Research topics include ethical theories,
informed consent, ethics committees and organ transplantation.
The Center for Biomedical Ethics and Law (CBEL) was recently set
up as an adjunct to the Department of Biomedical Ethics.
(http://www.cbel.jp/)
Study of the functions and responsibilities of ethics committees inJapan
Outreach Program: CBEL provides training courses for ethics committee
members. Participants include physicians, nurses and medical● Study of the methods for the formation of social consensus related
pharmaceutical representatives.
to advanced medical technology● Comparative study of clinical ethics in the Asian region● Acceptability of advance directives in Japan● Development of evaluation methods for biomedical ethics education● Psychosocial and ethical aspects of living related organtransplantation●

Health Policy

http://publichealth.m.u-tokyo.ac.jp/

Health Policy is the academic fields in which scientificevidence is collected, established, accumulated, anddisseminated for health policy making. Through studies invarious aspects in health policy, our department aims toadvance research, support policy development, andpromote education toward these ends. This department is
concurrently operated with Department of Public Health.
Efficiency and equity issues of health systems
Health manpower policy● Occupational and environmental epidemiology● Health services research●●Contribution of cause specific death to changes in absolute inequalities
between each occupation and manufacturing

Healthcare Informatics

http://www.m.u-tokyo.ac.jp/medinfo/

The Department of Biomedical Informatics aims to reform medical
systems and make social contribution by applying information
technology to medical and clinical field including hospital
information management. The department develops innovative
methods that are applicable to medical information systems in theboundary area of healthcare and information science, establishes
infrastructures for information environment, and applies knowledge
and technique acquired through these efforts to medical andhealthcare field.
The main keywords of the target domain are medical and clinicalinformation systems, next-generation electronic health record
systems, virtual health care environment, and AI including natural
language processing as well as machine learning.
Automatic Mapping from Clinical Case Dara toDevelopment and application of clinical ontology
Knowledge of Disease Transition
Research for sharing healthcare data among medical institutions
and hospitals, and the application for clinical epidemiology● Extraction of medical knowledge from electronic medical record database using natural language processing● Development of knowledge-driven real time alerting system in clinical practice● R&D of medical artificial Intelligence and mobile healthcare system●●

51

Clinical Information Engineering

http://webpark1893.sakura.ne.jp/wp/researches/

Clinical Information Engineering focuses on computer applications
that address biomedical data (collection, analysis, representation). It
is a combination of information science, computer science, andclinical science designed to assist in the management and processingof data, information and knowledge to support the practice anddelivery of clinical care and public health.
●●

ClinVR: Clinical Interactive 3D Computer Graphics & Virtual reality
PHI: Social information engineering for Public Health (Public Health
Informatics: GIS for Health Science etc.)

Forensic Medicine

http://ut-forensic.jp

We conduct autopsies, and various examinations including histology,
biochemistry, radiology, toxicology, and genetics as usual practices. We also
perform the following research with other institutes and departments
including Education and Research Center of Legal Medicine, Chiba University.
Analysis and pathophysiology of illegal drugs including new psychoactive
substances.
● Application of imaging modalities such as CT, or MRI for death investigation.
● Age and stature estimation and sex determination using CT .
● Mechanical properties of human tissue.
● Diagnosis of drowning.
● Application of relatively new DNA testing
method for practice of forensic medicine●

Forensic autopsy room

CT room

Global Environmental Health
The Department of Global Environmental Health (GEH) aims
to study the relationships between the environment andhuman health and to produce well-educated professionals
with the ability to undertake epidemiological research. Our
research interest includes climate change and variability, air
pollution, and human health across multiple countries inenvironmental epidemiology. We address the scientificquestions how the environmental factors are associated withhealth outcomes and potential socio-economic determinants
that modify the exposure-response associations. The GEH
provides two courses, 1) Environmental Health and 2)
Methods for Environmental Health Research.
Health risk assessment of climate change and air pollution
in East Asia
● Seasonality of suicide and associations between suicide
and weather in multi-city multi-country (MCC) network● Statistical prediction model development for malaria early
warning system in Southern Africa●

52

https://sites.google.com/m.u-tokyo.ac.jp/envhealth

Geographical distribution of the MCC network
for the suicide-temperature association study

Center for
Disease Biology and Integrative Medicine

Molecular Biomedicine for Pathogenesis
A variety of biological garbage such as necrotic cells, cancerous cells,
excess lipids, or degenerated cells and proteins, are constitutively
developed in our body. Such undesired substances are usuallyeliminated quickly, which is followed by tissue regeneration.
Abrogation of such "removal system" may cause accumulation of
garbage in tissues, accompanied by the secondary inflammation andfibrosis, resulting in the development of types of diseases. Thus, thisscavenging response is essential to maintain the body in homeostasisand healthy state. Our overall goal is to apply our findings to develop
a novel therapy based on this system against diseases.

http://tmlab.m.u-tokyo.ac.jp/english/index.html
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Elucidation of molecular mechanism of "removal system"
conducted by serum protein AIM.
● Comprehension of diseases caused by abrogation of this removal
system: acute kidney injury, chronic kidney disease, cancer,
obesity, neurodegenerative diseases, autoimmune diseases,
aging, etc.
● Development of novel therapies against diseases.
●

Structual Physiology೺ᗣ⥔ᣢYƵŝĐŬƌĞŵŽǀĂů

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ŝƐĞĂƐĞ

http://www.bm2.m.u-tokyo.ac.jp/index-e.html

We have been exploring two-photon excitation microscopy, which
utilizes an infrared femtosecond-pulsed laser as a light source, tovisualize and stimulate intact tissues at the cellular and molecularlevels. We focus on the functions and disorders of the brain andsecretory organs.
The dynamics of synapses in the cerebral cortex, in relation tomemory, cognitive processes and mental disorders● Molecular mechanisms of exocytosis in synapses and the islet of
Langerhans, and their optical control●

Fine structure and function of a central neuron studied
with two-photon excitation imaging and uncaging

53

Biomedical Equipment and Biomaterial

http://www.cdbim.m.u-tokyo.ac.jp/
English Versioの作製お願いします。
Application of deep learning forelectrophysiological mapping

Coupling of physical energy with
nanoparticles for medicine

Prediction of membrane potential distribution
from sparse electrode signals by deep learning

Nanoparticles for photodynamic therapy

Prediction

GT

We aim to create a basic methodology for research and development of new
biomedical equipment and biomaterial applicable clinical site by integrating
bioengineering technology such as mechanical, measurement, material andchemical engineering. For medical equipment, we are challenging to apply
recent information theories such as compressive sensing and machine learning
to achieve high quality biometrics from low invasive ultrasound and electricalbiometric signals. For biomaterial, we develop new biocompatible hydrogels
based on polysaccharides, hyperbranched polymers, and DNA analogues,
which materials are applied to drug delivery systems for peritoneal diseases,
artificial red blood cells, and artificial pancreas islets.

Optical/electrical simultaneous measurement
system for validation of electrical mapping

Transparent electrodes「Injectable hydrogels for
medical uses」「Porous materials for medical uses」

Hyaluronan, alginate, gelatin etc.

Application of deep learning for cardiac electrical mappingHigh speed fluorescence measurement by compressed laminar optical
tomography● Fabrication of new biocompatible hydrogels and particles● Development of anti-peritoneal adhesion barrier, hemostats● Drug delivery for peritoneal diseases, mesothelioma, liver cirrhosis, scleroderma● Coupling of physical energy and nanoparticles for novel diagnostics/therapy●

Anti-adhesion barriers●

Clinical Biotechnology

Delivery of nanoparticles into brain assisted byfocused ultrasoundBone regeneration「Particles for medical uses：from nano to micro」
CDDP-loaded nanogels
for DDS

Oxygen carriers

Drug delivery： peritoneal metastasis・mesothelioma・liver cirrhosis・scleroderma
Tissue engineering： scaffolds・capsules ・oxygen carriers
Materials for minimally invasive surgeries： anti-adhesion, hemostat, etc

http://www.tetrapod.t.u-tokyo.ac.jp/ohba-tei/en/

We pursue two scientific interests with a particular focus onskeletal tissues (bones and cartilages): (1) manipulation ofprogenitor cell differentiation and proliferation based onunderstanding of molecular mechanisms underlying cell fatespecification, and (2) development of novel biomaterials fulfillingcharacteristics required for in vivo use as scaffolds. We aim todevelop novel systems for skeletal tissue engineering andregenerative medicine, where cell differentiation and proliferation
are directly regulated in situ.
Understanding of epigenome dynamics and gene regulatory
landscape in cell fate specification by genome-scale andbioinformatic approaches● Identification of bioactive molecules for tissue regeneration,
inspired by the gene regulatory landscape in progenitor
differentiation and proliferation● Creation of highly functional and biocompatible materials, basedon design principle of biomaterials in materials science● Development of tissue-inducing implant devices, which act as acarrier of bioactive molecules as well as a scaffold for tissue
healing●

Development of osteoprogenitors expressing stage-specific molecules(green: Sp7, red: Runx2)

https://lmmhs.m.u-tokyo.ac.jp

Environmental and Metabolic Health Sciences
Lipids serve as the largest energy source, cell membrane components,
and bioactive mediators. Lipids are major environmental substances
supplied as nutrients and spatiotemporally regulate a variety of
biological responses in response to given microenvironmental cues
within tissues. Our research focuses on the regulation of biologicalnetworks driven by lipids and their metabolites. By taking advantagesof an array of gene-manipulated mice for lipid-metabolizing enzymes
and receptors, we aim to clarify novel lipid-orchestrated mechanisms
underlying various diseases such as metabolic and immune
disorders. Knowledges obtained from these approaches will betranslated to humans toward discovery of new biomarkers or
druggable targets.

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;хϳϬŐĞŶĞƐ䠅.QRFNRXWPLFH/LSLGRPLFV'LVHDVHV8QGHUVWDQGLQJRIVSDWLRWHPSRUDOOLSLGIORZVLQKHDOWKDQGGLVHDVHV'LVFRYHU\RIQRYHOOLSLGSDWKZD\VWKDWDUHOLQNHGWRELRORJLFDOSURFHVVHVAnimal Resources / Research Resources and Support - Animal Research
Our laboratory focuses on understanding the molecular mechanisms
which underlie the brain function and cancer development. We also
try to generate animal models for human genetic diseases. Recently
we established the gene targeting methods using CRISPR/Cas
system. We also manage the animal facilities, provide reproductive
technology service, advice on animal experiments, and give lectureson laboratory animals so that animal experiments are carried out inaccordance with animal welfare.
Molecular analysis of brain function and cancer using geneticallymodified mice
● Development of new model animals for human diseases● Development of gene targeting animals using CRISPR/Cas system●

A mutant mouse lacking metabotropic glutamate receptor
subtype-1 (mGluR1)

Molecular Radiology / Reserch Resources and Suport-Radiation Biology

http://www.cdbim.m.u-tokyo.ac.jp/
english/index.html

We are investigating the molecular mechanisms of DNA double-strand
break repair as the scientific basis of radiation therapy andchemotherapy in medical oncology. We also promote the basic researchthat contributes to the development of a novel therapeutic strategy byexamining a link of the DNA metabolic network including DNA
replication and cell cycle control with chromosome instability.
Molecular mechanisms of homologous recombinational repair
Mechanisms of the choice between homologous recombination andnon-homologous end-joining● Molecular mechanisms of DNA rereplication● Mechanisms of the genesis of aneuploidy● Functional analysis of meiotic recombination genes●●

Centrosome fragmentation which may lead to aneuploidy

Biomedical Informatics

http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

The department conducts researches on the development of medical
artificial intelligence systems and their application to clinical practice(i.e., clinical decision support, knowledge discovery from big data, andso on), utilizing the combined approach of medical knowledge
representation, logical reasoning, and machine learning techniques. We
actively collaborates with the department of Medical informatics,
Graduate School of medicine, and the department of Planning,
Information and Management in the University of Tokyo Hopistal, to
conduct those researches using clinical information. Our activities also
include the practical management of information infrastructure to
support medical researches.
Development and application of clinical ontology
Development of clinical decision support systems using logicalreasoning and machine learning● Clinical text analysis and knowledge extraction using natural language
processing● Development of next-generation EHR system●●

Computer System for Biomedical Research

55

The International Research Center
for Medical Education

Department of Medical Education
The mission of Department of Medical Education includes promotionof medical education not only in Faculty of Medicine, the Universityof Tokyo but also of the whole country. This department works onactivities of educational practice or improvement and promotes
research related to medical education field. In the university, thisdepartment offers educational activities such as clinical clerkship,
PBL (problem-based learning) and clinical skill practical training.
The department operates OSCE (objective structured clinicalexamination).

Clinical Simulation Center

International Cooperation for Medical Education
This is a department that disseminates basic theory on medical/
health professions education domestically and internationally,
thereby improving health care in a broader sense. In particular, ourstrengths include learner assessment, program evaluation, clinicalreasoning/ clinical decision making, general practice/ family
medicine/ primary care, health communication, and patient-healthprovider relationship. In addition, we are involved in human resource
development in the field of health care and its international
cooperation, and support projects related to medical/ healthprofessions education in Japan and overseas.

One scene of a faculty development workshop

56

Global Nursing Research Center

Division of Care Innovation
With a falling birthrate and a super-aging society, Japan is in need of a shift in focus that will emphasize the role of a
supportive medical care. Here, we seek to develop a nursing science that will foster an interdisciplinary research/educational
environment aiming to nurture young nursing researchers who can lead care innovation. This division, with bio-scientist/
engineering researchers and companies working together, aims to develop care products that reduce the various
inconveniences of daily life faced by each person with health impairments. To that end, we seek to accept young researchersand establish an innovative nursing research fields based on transdisciplinary integration.
●

Robotics Nursing●●●

Biological Nursing
●

●

●

●

Development of an educational program for teaching visualization techniques using
ultrasonography
Development of a tool that automatically measures bladder urine volume

Clinical Nursing Technology●●●

Development of a method for predicting pressure ulcer development through the use of skinblotting
Development of a method for detecting the presence of biofilm through the use of wound blotting

Visualized Nursing●●

Development of a robotic mattress that uses AI to monitor patients.
Development of a robot that can communicate with elderly people with dementia

Development of nursing techniques for the early detection of extravasation using thermo-sensitive
liquid crystal film
Improving our understanding of the mechanisms involved with infiltration and extravasation

Reverse Translational Research●●

Improving prevention care for diabetic foot ulcers
Development of an international standard scale for evaluating diabetic foot ulcer

Division of Nursing System

We promote research activities with the aim of ‘providing nursing practice solutions that reflect important cultural andsocial concerns, constructing Japan-origin nursing theories that support high quality practices, and making policy
proposals.’ Health Quality and Outcome Research department contributes to developing a methodology to evaluate theirhealth quality well, conducting studies using outcomes from theirperspectives, and then finally creating new effective and optimized
nursing systems in order to improve the total of quality of life and healthquality among. At the Department of Care Quality Management, we
explore new research methodologies/innovations of research for carequality assurance and continuous quality improvement system.
●

Health Quality and Outcome Research
●
●
●
●

●

Practice and evaluate nursing care directly or indirectly
Deploy research using patient-reported outcomes
Explore new health quality indicator
Develop evaluation methodologies to understand health quality among
overall family and nursing system wellCare Quality Management●●●●

Knowledge development in caring practice
Support for care workers
Care quality assurance in community care system
Development of quality indicators and benchmarking

57

Institution

The Office of International Academic Affairs

http://koryu.m.u-tokyo.ac.jp/homepage10.html

The Office of International Academic Affairs is under the direct authority of the
Dean of the Graduate School of Medicine. Its four most important roles, as
defined by the Committee on International Academic Affairs, are i) international
educational exchange, ii) international contacts in research and scientific fields,iii) helping young researchers excel not only as scientists, but also as educators
for the next generation and as administrators of their research groups, and iv)
holding Medical English classes and developing language-teaching materials
for medical students.

Medical Scientist Training Program
Medical Scientist Training Program was launched in 2008, aiming
medical students have the opportunity to experience basic research intheir early years and learn the attitude researcher.Students taking thisprogram will activities such as journal clubs and English courses ofMedical Research Communications as well as their own research in labs,
retreat and the defense of research honors theses. Students are also
expected to build up a network among medical students who intend to
be a researcher through the program support, such as the short term
stay at labs abroad, participations to the symposium, and the excursion
with other universities.

58

http://www.ut-mdres.umin.jp/

Office for Human Research Studies
Office for Human Research Studies (OHRS) aims to protect the rights, health,and dignity of research participants. Based on this principle, OHRS supports
researchers at the Graduate School of Medicine, the Faculty of Medicine andthe University Hospital to perform their studies in an ethical manner. Our
primary task is the management of the Ethics Committee secretariat.
Additionally, we plan and manage research ethics seminars, provide ethics
education to researchers through consultations, develop human resources for
future research ethics specialists, and conduct related researches.

Life Sciences Core FacilityLife Sciences Core Facility provides researchers at the graduate school of
medicine and the faculty of medicine access and technical assistance tospecialized instruments including mass spectrometers, cell sorters, flow
cytometers and a state-of-the-art fluorescent microscope.

The Office for Clinical Practice and Medical Education
The Office for Clinical Practice and Medical Education was established in April
2015 to promote medical education, especially clinical training for the 5th- and6th-year medical students.
We facilitate the clinical clerkship program and establish liaison between
students, faculty and other medical institutions, as well as enhance theclerkship curriculum and evaluation methods.
For individual students, we provide extended support by collaborating with thestudent support office and the educational office of the faculty of medicine.
With the International Research Center for Medical Education and other medical
faculties, we also conduct research on medical education, particularly on therelationship between high-stakes examination and important educational
outcomes, and the relationship between the scores and daily life.

59Medical Libraryhttps://www.lib.m.u-tokyo.ac.jp

The University of Tokyo Medical Library was opened in 1961 as a model of theJapanese modern medical library. The view makes it a perfect place toconcentrate on study.
The library has adopted an open stack system so that users can have directaccess to almost all the materials.
Holdings:
Books(number of volumes) : 273,607 (Japanese 109,946 Foreign 163,661)
Periodicals(number of titles) :3,997 (Japanese 2,005 Foreign 1,992)● Visitors: 95,462● Borrowed Books: 17,246●(as of March 31 2018)

Museum of Health and Medicine

http://mhm.m.u-tokyo.ac.jp/

Museum of Health and Medicine was planned as part of commemorative projects to celebrate the anniversary of thefounding of the School and the University of Tokyo Hospital, and was opened on 20, 2011. The permanent exhibition was adisplay medical archives and instruments from the early era, Ishihara’s Color Blind Test Charts and a developed at the
University. Special exhibitions planned to promote understanding among the regarding advances in medical science andhealth.
We moved to the South Clinical Research Bldg. in April 2019.

60

Ikenohata Gate

East ClinicalResearch Bldg.

Advanced ClinicalResearch Center

ClinicalResearch Ward

Molecular &Life Innovation
Bldg.

Ward A

ClinicalResearch Bldg.A

First Research
Bldg.

Ward B

Central Bldg.
(East wing)
Central Bldg.
(South wing)
Central Clinical
Service Bldg.1
Central Clinical
Service Bldg.2

Administration &Research Bldg.

Med.4

ClinicalSouth ClinicalResearch Bldg.

Tatsuokamon Gate

MedicalLibrary

International
ResearchCenterMed.2

Med.5
Bioscience
Reseach Bldg.
Med. Experimental
Research Bldg.

Med.3

Kasuga Gate

Med.1

Main Gate

AkamonGate

Hongo-sanchome Stn.
on Subway Line
: Marunouchi Line: Oh-edo LineNobuhito Saito
Dean, Faculty of Medicine, Graduate School of Medicine
The University of Tokyo
Address:7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
http://www.m.u-tokyo.ac.jp

Issued on May, 2019