PROSPECTUS 2023−2024

A Message From the Dean of Faculty of Medicine andGraduate School of Medicine, the University of Tokyo
Medicine has two important aspects. Medicine is basic science to elucidate life phenomenon.
Medicine is also applied science to conquer disease and contribute to human welfare. During its long
history of more than 160 years, the University of Tokyo School of Medicine has trained numerous
medical researchers and health-care professionals, many of whom have distinguished themselves inJapan and other countries. We in the Graduate School of Medicine aim to build on these achievements
and to continue to play a leading role in promoting human welfare.
Several new projects have been implemented to strengthen the foundation of our research andclinical activities. The Molecular & Life Innovation Building is promoting joint research with otherfaculties, including the Graduate School of Engineering and Graduate School of Science. ClinicalResearch Center Building A is functioning as a core clinical research facility. The South Research
Building now features the Iron-Gate (Tetsu-Mon) Clinical Lecture Hall. In basic research, theInternational Research Center for Neurointelligence (IRCN) was started as part of the World PremierInternational Research Center Initiative (WPI) in collaboration with the Graduate School of Medicine. A
new cryo-electron microscopy facility has been opened as a shared facility, allowing researchers insideand outside the University to contribute to the field of structural biology in Japan.
As part of our ongoing improvements in graduate education, the University of Tokyo has
successfully implemented multiple doctoral degree programs as part of the World-leading Innovative &Smart Education (WISE) program. In particular, the World-leading Innovative Graduate Study Programfor Life Science and Technology (WINGS-LST) helps graduate students acquire advanced expertise andbroad perspectives in the life sciences. As the core of life sciences research at the University of Tokyo,
we will continue to promote cutting-edge research, accumulate clinical resources, and encourage
cooperation with other university faculties.
Students and staffs of the Graduate School of Medicine of our university should become
international leaders in medicine and contribute to human welfare. All our laboratories provide young
researchers and students with a state-of-the-art research environment. Moreover, we promote an
atmosphere of inquiry in which students and principal investigators actively discuss important andemerging issues in the life sciences and medicine. This stimulating, interactive environment enables
students to establish clear goals for their own original research. Finally, the advanced medical careprovided at the University Hospital enables clinical studies that utilize the hospital’s rich clinical dataand is an optimal setting for research requiring big-data health-care analysis. Our fundamental mission
is to develop new technologies for preventing, diagnosing, and treating disease, to apply theseadvances in clinical settings, and to train the medical researchers and practitioners who will establish
the next generation of medicine.

Masaomi Nangaku, MD,PhD
Dean, Faculty of Medicine and Graduate School of Medicine,
The University of Tokyo

HISTORY
1858

May
Nov.

Practitioners, trained in Dutch (European) medicine in Edo (Tokyo), laid out money to establish
the Shutojo (vaccination center) in Kanda Mitamagaike.
Shutojo was destroyed in a fire that had spread from Kanda Aioicho. Shutojo continued its
operations at other sites such as the residence of Ito Genboku.

1859

Sep.

Shutojo was reconstructed at Shitaya Izumibashi Dohri.

1860

Oct.

Shutojo became an official medical institution of the Shogunate Government.

1861

Oct.

Shutojo was renamed as Seiyo Igaku-Sho (Institute of Western Medicine) and offered coursesof Western Medicine in the fields of Education, Autopsy, and Vaccination.

1863

Feb.

Seiyo Igaku-Sho was renamed as Igaku-Sho (Institute of Medicine).

1868

Jul.

Igaku-Sho, affiliated with the Military Hospital which had been moved from Yokohama to Todo
residence in Shitaya, was renamed as Daibyoin (the Great Hospital).

1869

Feb.
Dec.

The Daibyoin was renamed as Igakko-Ken-Byoin (Medical School and Hospital).
Igakko-Ken-Byoin was renamed as Daigaku Toko (University East Building).

1871

Jul.

The Ministry of Education was established and Daigaku-Toko was renamed as Toko (East
Building).

1872

Aug.

A School System was established. Toko was renamed as Daiichi-Daigaku-Ku- Igakko (The First
University District Medical School).

1874

May

Daiichi-Daigaku-Ku-Igakko was renamed as Tokyo-Igakko (Tokyo Medical School).

1876

Nov.

Tokyo-Igakko was moved to Hongo.

1877

Apr.

Tokyo Igakko, affiliated with Tokyo-Kaisei School, was renamed as The University of Tokyo.
Tokyo Medical School was renamed as The University of Tokyo Faculty of Medicine.

1886

Mar.

The University of Tokyo was renamed as Imperial University, and The University of Tokyo
Faculty of Medicine was renamed as the Imperial University Medical College. A Graduate
School was established.

1897

Jun.

The Imperial University was renamed as Tokyo Imperial University.

1917

Aug.

Eiraku Hospital, affiliated with the Ministry of Education Medical Practice License Examination,
moved to Tokyo Imperial University and was renamed as Koishikawa Hospital affiliated with
Tokyo Imperial University Medical College.

1919

Apr.

A faculty system was established renaming Tokyo Imperial University Medical College as theFaculty of Medicine.

1931

Feb.

The first building of the Faculty of Medicine was constructed.

1936

Jan.
Nov.

The Brain Research Laboratory was built with funds donated by Mr. Hisasaburo Horikoshi.
The second building of the Faculty of Medicine (main building) was constructed.

1947

Oct.

Tokyo Imperial University was renamed as The University of Tokyo.

1950

Apr.

The Institute of Nursing was renamed as The University Nursing School.

1953

Apr.
Jul.

The School of Health Care and Nursing was founded.
The Graduate School was founded, and the Division of Medical Doctor Biological Science wasestablished. The Brain Research Laboratory became the Brain Research Institute of the Facultyof Medicine.

1956

Apr.

The Midwives School was established.

1958

Apr.
May

The Division of Pharmaceutical Sciences became an independent faculty.
The University of Tokyo Faculty of Medicine celebrated its centennial anniversary.

1961

Mar.

The Medical Library was built in commemoration of the centenary.

Apr.

The Institute of Medical Electronics was established.

Apr.

The Research Institute of Logopedics and Pediatrics was established. The School of Health Careand Nursing was reorganized as the School of Health Sciences. The Graduate School of The
University of Tokyo was reorganized and the Division of Medical Doctor Biological Science
became the Faculty of Medicine. The Health science Course was established in the Medical
Science Division.

1965

2

1966

Sep.

The third building of the Faculty of Medicine was constructed.

1971

Apr.

The Laboratory of Animal Experiments was established.

1973

Mar.

The Animal Center for Biomedical Research was constructed.

1983

Jan.

An annex of the third building of the Faculty of Medicine was constructed.

1985

Sep.

The office of International Academic Affairs was established.

1987

Apr.

Specialized courses were introduced to the Graduate School of Medicine.

1992

Apr.

The School of Health Sciences became the School of Health Science and Nursing. The Schoolof International Health was established in the Medical Science Division.
The Radiation Research Institute was established.

Jul.
1995

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, four divisions,Third Basic Medicine, Social Medicine, Third and Fourth Clinical Medicine, were replaced with
Pathology, Immunology and Microbiology, Social Medicine, Reproduction and Development,
and Aging Science and Surgery.

1996

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First Clinical Medicine, Health Science, and International Health, were replaced with Internal
Medicine, Health Science and Nursing, and International Health.

1997

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First and Second Basic Medicine, and Second Clinical Medicine, were replaced with Molecular
Cell Biology, Functional Biology, Radiology and Biomedical Engineering, and Neuroscience.
As a result of the above-mentioned reorganization, three institutes, the Institute of Brain
Research, the Institute of Medical Electronics, and the Institute of Logopedics and Phoniatrics
were made redundant.

		

1999

Apr.

The Master course of Medical Science was established in the Graduate School of Medicine.
This course accepts graduates of all faculties except those from Schools of Medicine, Dentistry,and Veterinary Medicine.

2000

Apr.

The International Research Center for Medical Education was established (A shared facility foreducation and research).

2001

Apr.

The University Branch Hospital was united with the University Hospital.

2002 Mar.
		

Nursing School and Midwives School was closed.
Experimental Building (First Stage) was constructed.

2003 Apr.
		The Center for Disease Biology and Integrative Medicine was established.
The Radiation Research Institute and the Laboratory of Animal Experiments were integrated
into the Center for Disease Biology and Integrative Medicine.

2004

Apr.

All the National Universities owned by the Japanese Government became National University
Corporations. and the University of Corporation.

2005

Mar.

Experimental Building (Second Stage) was constructed.

2007

Apr.

The School of Public Health was established. This school offers programs for Master of Public
Health.

2008

May.

The University of Tokyo Faculty of Medicine and the University of Tokyo Hospital celebrated
their 150th anniversary.

2010

Apr.

The School of Health Science and Nursing became the School of Integrated Health Sciences.

2011

Jan.

The Museum of Health and Medicine was established.

2012

Apr.

The Office for Research Ethics Support was established.

2013

Apr.

The International Research Center for Medical Education became a facility of the Graduate
School of Medicine.

2013

Oct.

The Life Sciences Core Facility was established.

2015

Apr.

The Office for Clinical Practice and Medical Education was established.

2016

Apr.

The Advisory Office for Conflict of Interest was established.

2017

Apr.

The Global Nursing Research Center was established.

2021

Apr.

The Center for Diversity in Medical Education and Research was established.

3As of May, 2023

Graduate School of Medicine					

P16Molecular Cell Biology
分子細胞生物学
Cell Biology
Cell Biology and
Structural Biology
P16
AnatomyBiochemistry andMolecular Biology*Joint Program

Dean Masaomi Nangaku

Professor
Professor

Cytoarchitectonics
Cellular Neurobiology
Molecular Biology

Professor
Professor
Associate Professor
Professor
Genome Informatics
Associate Professor
Physiological Chemistry and Metabolism Professor
Associate Professor
Professor
Advanced Structural Studies

Yasushi Okada
Masahide Kikkawa
Shigeo Okabe
Noboru Mizushima
Ikuko Honda
Yukinori Okada
Qingbo Wang
Hiroki Kurihara
Yukiko Kurihara
Radostin Danev

Clinical Genome Informatics / Medical Lipid Science / Cancer Cellular Signaling

機能生物学
Functional Biology
P19

19
PPhysiology
Pharmacology*Joint Program

Integrative Physiology
Cellular and Molecular Physiology
Neurophysiology
Cellular and Molecular Pharmacology
Systems Pharmacology

Professor
Kenichi Ohki
Professor
Masanori Matsuzaki
Professor
Kenichi Ohki
Professor
Kenzo Hirose
Professor
Hiroki Ueda
Project Associate Professor Yoichi Minami

Brain Functional Dynamics

Pathology, Immunology and Microbiology
病因･病理学P21

Pathology
P21

Pathology and Diagnostic Pathology

Microbiology

Molecular Pathology
Microbiology

Immunology

Infection Control and Prevention
Immunology

Applied Pathology*Joint Program

Professor
Tetsuo Ushiku
Associate Professor Daizo Koinuma
Professor
Yasuhiro Yamada
Professor
Makoto Takeda
Associate Professor Hiroshi Katoh
Professor
Takeya Tsutsumi
Professor
Hiroshi Takayanagi
Associate Professor Takeshi Nitta
Associate Professor Noriko Komatsu
Distinguished
University Professor Kohei Miyazono

Tumor Pathology / Infection Pathology / Molecular Oncology

Radiology and Biomedical Engineering
生体物理医学P24

Radiology
P24
Biomedical
Engineering

Professor
Associate Professor
Associate Professor
Radiotherapy
Nuclear Medicine
Associate Professor
Associate Professor
System Physiology
Chemical Biology and Molecular Imaging Professor
Associate Professor

Diagnostic Radiology

Biosystem Construction and Control
Integrative Genomics

4

Osamu Abe
Takeyuki Watadani
Hideomi Yamashita
Hidemasa Takao
Kimiko Yamamoto
Yasuteru Urano
Ryosuke Kojima

Professor
Katsutoshi Oda
Associate Professor Aya Ushiku

Neuroscience
脳神経医学
P26

Neuropathology
Neurochemistry
Neurobiology
Integrative Medical Developmental Neuroscience
Cognitive Neuroscience
Neuroscience
Systems Medical Neuroscience
Child Neuropsychiatry
Clinical Neuroscience Neuropsychiatry

Basic Neuroscience
P26

Neurology*Joint Program

Professor
Professor

Takeshi Iwatsubo
Haruhiko Bito

Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor

Yukiko Kano
Kiyoto Kasai
Seiichiro Jinde
Shuntaro Ando
Tatsushi Toda
Wataru Satake
Nobuhito Saito

Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Shumpei Ishikawa
Hiroto Katoh
Takahiro Higashi
Haruhiko Inada
Hirotaro Iwase
Yohsuke Makino
Kazuhiko Ohe
Kayo Waki

Neurosurgery
Biomedical Neural Dynamics / Brain Disorders

Social Medicine
社会医学
Preventive Medicine
Occupational,
P29
Environmental and
P29 Preventive Medicine Public HealthForensic Medicine,and Medical
Informatics andEconomics

Forensic Medicine*Joint Program

Cancer Control Policy and Research / Cancer Epidemiology / Cancer Communication

Biomedical Informatics

Internal Medicine
内科学
P31

Medicine I
P31

Cardiovascular Medicine
Respiratory Medicine
Gastroenterology

Professor
Associate Professor
Professor
Nephrology
Associate Professor
Professor
Endocrinology
Medicine II
Associate Professor
Professor
Nutrition and Metabolism
Associate Professor
Professor
Hematology and Oncology
Professor
Allergy and Rheumatology
Associate Professor
Professor
Infectious Diseases
Associate Professor
Stress Science and Psychosomatic Medicine Associate Professor
Professor
Clinical Laboratory Medicine
Clinical Laboratory
Professor
Medicine and Pathology Transfusion Medicine*Joint Program

Mitsuhiro Fujishiro
Ryosuke Tateishi
Masaomi Nangaku
Hiroshi Nishi
Masaomi Nangaku
Noriko Makita
Toshimasa Yamauchi
Nobuhiro Shojima
Mineo Kurokawa
Keishi Fujio
Hirofumi Shoda
Takeya Tsutsumi
Shu Okugawa
Kazuhiro Yoshiuchi
Makoto Kurano
Hitoshi Okazaki

Molecular Diabetology

5Reproductive, Development and Aging Sciences
生殖･発達･加齢医学
P35

Obstetrics and
PGynecology
35

Reproductive Endocrinology
Gynecological Oncology

Pediatric Sciences

Perinatal Medicine
Molecular Cellular Reproductive
Medicine
Pediatrics

Aging Sciences

Developmental Pediatrics
Pediatric Surgery
Pediatric Oncology
Geriatric Medicine*Joint Program

Aging Research
Health Policy for Children and Families / Medical Science for Life and Aging

Professor
Yutaka Osuga
Associate Professor Yasushi Hirota
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor

Yutaka Osuga
Osamu Hiraike
Motohiro Kato
Yutaka Harita
Hikoro Matsui
Jun Fujishiro

Professor
Masahiro Akishita
Associate Professor Sumito Ogawa
Professor
Masahiro Akishita

Surgical Sciences
外科学
Surgery

P37

P37

Sensory and Motor
System Medicine

Vital Care Medicine

6

Thoracic Surgery
Cardiovascular Surgery

Professor
Associate Professor
Professor
Gastrointestinal Surgery
Associate Professor
Professor
Hepatobiliary Pancreatic Surgery
Professor
Urology
Artificial Organ and Transplantation Division Professor
Professor
Surgical Oncology
Associate Professor
Professor
Vascular Surgery
Associate Professor
Associate Professor
Breast and Endocrine Surgery
Professor
Dermatology
Associate Professor
Professor
Plastic and Reconstructive Surgery
Associate Professor
Professor
Oral and Maxillofacial Surgery
Associate Professor
Professor
Orthopaedic Surgery
Associate Professor
Associate Professor
Professor
Ophthalmology
Associate Professor
Associate Professor
Associate Professor
Otolaryngology and Head and Neck
Surgery
Associate Professor
Professor
Rehabilitation Medicine
Professor
Anesthesiology
Emergency and Critical Care Medicine Associate Professor

Minoru Ono
Yasutaka Hirata
Yasuyuki Seto
Sachiyo Nomura
Kiyoshi Hasegawa
Haruki Kume
Kiyoshi Hasegawa
Soichiro Ishihara
Hiroaki Nozawa
Soichiro Ishihara
Katsuyuki Hoshina
Masahiko Tanabe
Shinichi Sato
Sayaka Shibata
Mutsumi Okazaki
Shimpei Miyamoto
Kazuto Hoshi
Hideto Saijo
Sakae Tanaka
Taku Saito
Yasushi Oshima
Makoto Aihara
Megumi Honjo
Ryo Obata
Kenji Kondo
Akinori Kashio
Toru Ogata
Kanji Uchida
Kent DoiHealth Sciences and Nursing
健康科学･看護学
P44

Health Sciences
P44

Preventive andAdministrative
Nursing
Clinical Nursing

Health Sociology
Mental Health
Epidemiology and Preventive Health
Sciences
Biostatistics
Health Education
Biomedical Ethics
Advanced Clinical Nursing
Nursing Administration
Family Nursing
Community Health Nursing
Public Health Nursing
Gerontological Home Care andLong-term Care Nursing
Palliative Care Nursing
Midwifery and Women's Health
Psychiatric Nursing*Joint Program

P48

Gerontological Nursing
Wound Care Management
Public Mental Health Policy

International Health
国際保健学International Social Global Health Policy
48
PMedicineInternational
Biomedical Sciences

Community and Global Health
Human Genetics
Developmental Medical Sciences
Human Ecology
Biomedical Chemistry

P51

Schoolof Public Health
公共健康医学
Biostatistics
Epidemiology and
51 Sciences
PHealthProfessor
Daisuke Nishi
Professor
Yutaka Matsuyama
Associate Professor Koji Oba
Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor

Hideki Hashimoto
Yoshiyuki Takimoto
Aya Kitamura
Aya Kitamura
Mari Ikeda
Kyoko Yoshioka-Maeda

Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor

Noriko Yamamoto-Mitani
Ayumi Igarashi
Noriko Yamamoto-Mitani
Megumi Haruna
Daisuke Nishi
Yuki Miyamoto
Gojiro Nakagami
Gojiro Nakagami

Professor
Masahiro Hashizume
Associate Professor Chris Fook Sheng Ng
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor

Akihiro Fujimoto
Motoko Unoki
Moi Meng Ling
Masahiro Umezaki
Shoko Konishi
Tomoyoshi Nozaki
Yoh-ichi Watanabe

Professor

Yutaka Matsuyama

Associate Professor Koji Oba

Social and Preventive Epidemiology
Clinical Epidemiology and Health Economics Professor
Professor
Health Communication

Behavioral Health
Sciences

Health Services
Sciences*Joint Program

Hideo Yasunaga
Takahiro Kiuchi
Associate Professor Tsuyoshi Okuhara
Professor
Daisuke Nishi

Mental Health
Health Sociology and Health Education
Professor
Hideki Hashimoto
Health and Social Behavior
Associate Professor Yoshiyuki Takimoto
Health Promotion Sciences
Associate Professor Yoshiyuki Takimoto
Biomedical Ethics
Health Policy
Professor
Kazuhiko Ohe
Healthcare Informatics
Professor
Hiroshi Oyama
Clinical Information Engineering
Professor
Hirotaro Iwase
Forensic Medicine and Medical Law
Global Environmental HealthPublic Health Science

Associate Professor Yohsuke Makino
Associate Professor KIM Yoonhee

7Center for Disease Biology and Integrative Medicine
疾患生命工学センター

Director Haruhiko Bito

Laboratoryof Molecular Biomedicine for Pathogenesis
センター長
尾藤晴彦

P55

Laboratory of Structural Physiology

P55Laboratory of Biomedical Equipment and Biomaterials
Laboratory of Clinical Biotechnology

Laboratory of Microenvironmental and Metabolic Health
Sciences
Laboratory of Animal Resources
Laboratory of Molecular Radiology
Laboratory of Biomedical Infomatics

Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor

医学教育国際研究センター
The International Research Center for Medical Education
センター長
Department
相原 一of Medical Education Studies

P58 P58

Director Makoto Aihara

Professor

Masato Eto

Department of International Cooperation for Medical Education

グローバルナーシング
Global Nursing Research Center
リサーチセンター
Divisionof Care Innovation
センター長
山本則子

P59 P59

Kanako Harada
Ungil Chung
Hironori Hojo
Makoto Murakami
Seiichiroh Ohsako
Atsu Aiba
Noriko Hosoya
Takeshi Imai

Division of Care Systems

Director Noriko Yamamoto-Mitani
Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor

Gojiro Nakagami
Megumi Haruna
Aya Kitamura
Noriko Yamamoto-Mitani
Kyoko Yoshioka-Maeda
Ayumi Igarashi

医学のダイバーシティ
教育研究センター
Director Kiyoto Kasai
Center for Diversity in Medical Education and Researchセンター長 笠井清登
Associate Professor
Yoshihiro Satomura
Center for Diversity in Medical Education and Research

P60 P60

教育研究関連施設
Institution
Medical Library

P61

P61 Office of International Academic Affairs
Medical Scientist Training Program
Museum of Health and Medicine
Office for Human Research Studies
Life Sciences Core Facility
The Office for Clinical Practice and Medical Education
Advisory Office for Conflict of Interest

8

Director
Director
Director
Director
Director
Vice Director
Director
Director
Director

Hideo Yasunaga
Shinichi Sato
Shumpei Ishikawa
Kazuhiko Ohe
Masahiro Akishita
Yuzaburo Uetake
Masahide Kikkawa
Masato Eto
Saeko Aketani

Endowed Department
Department of Bone & Cartilage Regenerative Medicine
Department of Immunotherapeutics
Department of Advanced Clinical Science and Therapeutics
Computational Diagnostic Radiology and Preventive Medicine

Project Associate Professor
Project Professor
Project Associate Professor
Project Professor
Project Associate Professor
Project Professor
Science for Joint Reconstruction
Project Associate Professor
Department of Therapeutic Strategy for Heart Failure
Project Associate Professor
Department of Osteoimmunology
Project Professor
Department of Biostatistics and Bioinformatics
Laboratory for Advanced Research on Pathophysiology of Metabolic Diseases Project Associate Professor
Project Professor
Department of Home Care Medicine
Project Associate Professor
Department of Advanced Cardiology
Project Associate Professor
Artificial Intelligence in Healthcare
Project Professor
Comprehensive radiation oncology
Project Associate Professor
Research on Cell Therapy of Regenerative Medicine
Project Associate Professor
Department of Frontier Cardiovascular Science
Clinical application for Development of Therapy for Rare and Intractable Diseases Project Associate Professor

Yasunori Omata
Kazuhiro Kakimi
Mutsuo Harada
Takeharu Yoshikawa
Soichiro Miki
Toru Moro
Eisuke Amiya
Kazuo Okamoto
Daisuke Koide
Miki Iwabu
Takashi Yamanaka
Katsuhito Fujiu
Yoshimasa Kawazoe
Keiichi Nakagawa
Chang Dehua
Seitaro Nomura
Kazuki Taoka

Social Cooperation Program
Project Professor
Project Associate Professor
Project Professor
Project Associate Professor
Project Associate Professor
Department of Functional Genomics and Immunological Diseases Project Associate Professor
Department of Prevention of Diabetes and Lifestyle-Related Diseases Project Associate Professor
Department of Next-Generation Pathology Information Networking Project Professor
Project Professor
Chronic kidney disease pathophysiology
Project Professor
Tissue stem cell / life dentistry

Department of Lipidomics
Department of Health Services Research
Department of Healthcare Quality Assessment

Department of Preventive Medicine for Locomotive Organ
Disorders
Department of Eat-loss Medicine
Next-Generation Precision Medicine Development Laboratory
Department of Pain & Palliative Medical Sciences
Department of Retinal Biology and Pathology
Department of Medical Information Engineering
Laboratory for cryo-electron microscopy
Department of Digital Mental Health

Project Professor

Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor
Project Professor
Project Associate Professor
Project Professor
Department of Cellular and Tissue Communication
Project Professor
Clinical stem cell biology
Project Associate Professor
Department of Precision Medicine Nurology
Project Associate Professor
Department of Real-world Evidence
Project Associate Professor
Next-generation Endoscopic Computer Vision
Project Professor
Department of Healthcare economics and Health policy
Project Associate Professor
Department of Clinical Cannabinoid Research
Department of nutritional epidemiology and behavioral nutrition Project Professor
Project Associate Professor
Division of Musculoskeletal AI System Development

Faculty of Medicine

Yoshiya Oda
Taisuke Jo
Hiroaki Miyata
Hiraku Kumamaru
Hiroyuki Yamamoto
Tomohisa Okamura
Satoko Yamaguchi
Takeshi Sasaki
Reiko Inagi
Makoto Komura
Noriko Yoshimura
Kazumichi Yonenaga
Hidenori Kage
Maiko Hasegawa
Toshiro Iwagawa
Taichi Kin
Chieko Saito
Norito Kawakami
Kotaro Imamura
Jun Yamashita
Atsuhiko Hikita
Jun Mitsui
Yusuke Sasabuchi
Yosuke Tsuji
Tomoyuki Takura
Ayumi Yoshizaki
Kentaro Murakami
Hiroyuki Oka

Dean Masaomi Nangaku

School of Medicine

Cell Biology and Anatomy / Biochemistry and Molecular Biology / Physiology / Pharmacology / Pathology / Microbiology /Immunology / Radiology / Biomedical Engineering / Basic Neuroscience / Integrative Medical Neuroscience /Clinical Neuroscience / Occupational, Environmental and Preventive Medicine / Medical Principles and Medical Ethics /Forensic Medicine, and Medical Informaticsand Economics / Medicine I / Medicine II / Clinincal Laboratory Medicine andPathology / Obstetrics and Gynecology / Pediatric Science /Aging Science / Sugery / Sensory and Motor System Medicine /Vital Care Medicine

School of Integrated HealthSciences

Family Nursing / Community Health Nursing / Fundamental Nursing / Gerontological Nursing / Midwifery and Women's
Health / Adult Health and Nursing / Mental Health and Nursing / Health Sociology /Health Administration / Epidemiology andBiostatistics / Human Ecology /Biochemistry and Nutrition / Maternal and Child Health9University Hospital					Director Sakae Tanaka

Hospital
診療科 Management Support Organization
Office of Personnel and Human Resources
Office of Performance Monitoring and Risk Magamenet
Office of Education and Staff Development
Office of Hospital Planning and Management
Office of Research Support

Professor
Professor
Professor
Professor
Professor

Kiyoto Kasai
Kanji Uchida
Yutaka Osuga
Haruki Kume
Yutaka Osuga

Clinical Management Organization
Office of Inpatient Services
Office of Outpatient Services
Office of Central Clinical Services
Office of Patient Support

Professor
Mitsuhiro Fujishiro
Professor
Toshimasa Yamauchi
Associate Professor Masahiko Sumitani
Professor
Kiyoto Kasai

Clinical Services
Department ofInternal Medicine

General Internal Medicine
Cardiovascular Medicine
Respiratory Medicine

Professor

Professor
Associate Professor
Professor
Nephrology and Endocrinology
Associate Professor
Associate Professor
Professor
Diabetes and Metabolic Diseases
Associate Professor
Hematology and Oncology
Professor
Professor
Allergy and Rheumatology
Associate Professor
Professor
Infectious Diseases
Associate Professor
Professor
Neurology
Associate Professor
Professor
Geriatric Medicine
Associate Professor
Psychosomatic Medicine
Associate Professor
General Surgery
Professor
Professor
Stomach and Esophageal Surgery
Associate Professor
Professor
Colon and Rectal Surgery
Associate Professor
Professor
Hepato-Biliary-Pancreatic Surgery
Associate Professor
Professor
Vascular Surgery
Associate Professor
Breast and Endocrine Surgery
Associate Professor
Artificial Organ and Transplantation Surgery Professor
Associate Professor
Cardiovascular Surgery
Professor
Gastroenterology

Department ofSurgeryThoracic Surgery
Neurosurgery
Anesthesiology and Pain Relief Center
Urology and Andrology
Gynecologic Surgery

10

Associate Professor
Associate Professor
Professor
Professor
Professor
Professor
Associate Professor
Associate Professor

Tatsushi Toda

Mitsuhiro Fujishiro
Ryosuke Tateishi
Masaomi Nangaku
Noriko Makita
Hiroshi Nishi
Toshimasa Yamauchi
Nobuhiro Shojima
Mineo Kurokawa
Keishi Fujio
Hirofumi Shoda
Takeya Tsutsumi
Shu Okugawa
Tatsushi Toda
Wataru Satake
Masahiro Akishita
Sumito Ogawa
Kazuhiro Yoshiuchi
Soichiro Ishihara
Yasuyuki Seto
Sachiyo Nomura
Soichiro Ishihara
Katsuyuki Hoshina
Kiyoshi Hasegawa
Nobuhisa Akamatsu
Soichiro Ishihara
Katsuyuki Hoshina
Masahiko Tanabe
Kiyoshi Hasegawa
Nobuhisa Akamatsu
Minoru Ono
Yasutaka Hirata
Masaaki Sato
Nobuhito Saito
Kanji Uchida
Haruki Kume
Yutaka Osuga
Miyuki Harada
Osamu HiraikeDepartment of
Sensory andMotor System
Medicine

Department ofPediatrics, Perinatal
and
Women's Medicine
Department of
Neuropsychiatry
Department ofRadiology

Dermatology

Professor
Professor
Associate Professor
Associate Professor
Professor
Orthopaedic Surgery and Spinal Surgery
Associate Professor
Associate Professor
Otolaryngology and Head and Neck Surgery Associate Professor
Associate Professor
Professor
Rehabilitation Medicine
Associate Professor
Plastic, Reconstructive and Aesthetic Surgery Professor
Associate Professor
Oral-Maxillofacial Surgery and Orthodontics Professor
Associate Professor
Professor
Pediatrics
Associate Professor
Associate Professor
Pediatric Surgery
Professor
Professor
Obstetrics and Gynecology
Associate Professor
Professor
Neuropsychiatry
Associate Professor
Associate Professor
Professor
Radiology
Associate Professor
Associate Professor
Associate Professor
Ophthalmology

Department ofEmergency and Critical Care
Emergency andCritical Care Medicine Medicine
Advanced Medical Center
Department offor Heart Failure
Cross-Sectional
Center for Cardiac Arrhythmias
Services
and Electrophysiology
Marfan Syndrome Center
Epilepsy Center
Dementia Center
Scleroderma Center
Lupus Center
Osteoporosis Center
Center for Female Pelvic Medicine
and Reconstructive Surgery
Spine Center
Department of Clinical Genomics

Department of Child PsychiatryChildren, AYA and Family CenteredMental Care Center
Department of Pain and Palliative Medicine

Shinichi Sato
Makoto Aihara
Megumi Honjo
Takashi Miyai
Sakae Tanaka
Taku Saito
Yasushi Oshima
Kenji Kondo
Akinori Kashio
Toru Ogata
Sayaka Fujiwara
Mutsumi Okazaki
Shinpei Miyamoto
Kazuto Hoshi
Hideto Saijo
Motohiro Kato
Yutaka Harita
Hikoro Matsui
Jun Fujishiro
Yutaka Osuga
Yasushi Hirota
Kiyoto Kasai
Seiichiro Jinde
Shuntaro Ando
Osamu Abe
Hideomi Yamashita
Hidemasa Takao
Takeyuki Watadani

Professor

Kent Doi

Associate Professor

Takehiro Matsubara

Associate Professor

Masaru Hatano

Project Associate Professor Katsuhito Fujiu

Professor
Tatsushi Toda
Associate Professor
Hirofumi Shoda
Associate Professor
Masaru Hatano
Professor
Keishi Fujio
Associate Professor
Hiroshi Nishi
Associate Professor
Taku Saito
Professor
Yutaka Osuga
Professor
Haruki Kume
Professor
Soichiro Ishihara
Associate Professor
Yasushi Oshima
Professor
Katsutoshi Oda
Professor
Tatsushi Toda
Project Associate Professor Hidenori Kage
Associate Professor
Yukiko Kanou
Associate Professor

Yukiko Kanou

Associate Professor

Masahiko Sumitani

11

Central Clinical Services
Department of Pharmacy
Nursing Department
Department of Clinical Laboratory
Department of Blood Transfusion
Department of Pathology
Department of Infection Control and Prevention
Radiology Center
Rehabilitation Center
Surgical Center
Central Supply Service
Department of Clinical Engineering
Department of Endoscopy and Endoscopic Surgery
Department of Hemodialysis and Apheresis
Critical Care and Emergency Medical Center/ER
Department of Intensive Care Unit
Department of Pediatric and Neonatal Intensive Care Unit
Perinatal Center
Children's Medical Center
Department of Outpatient Chemotherapy Unit

Professor

Tappei Takada

Associate Professor
Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Professor
Professor
Professor
Associate Professor

Makoto Kurano
Hitoshi Okazaki
Tetsuo Ushiku
Aya Ushiku
Takeya Tsutsumi
Osamu Abe
Toru Ogata
Sayaka Fujiwara
Kazuhiko Fukatsu
Kazuhiko Fukatsu
Kent Doi
Yosuke Nakai
Masaomi Nangaku
Kent Doi
Takehiro Matsubara
Kent Doi
Naoto Takahashi
Hikoro Matsui
Yutaka Osuga
Motohiro Kato
Jun Fujishiro
Mitsuhiro Fujishiro
Hironori Ishigami

Cancer Center
Immune-Mediated Diseases Therapy Center

Organ Transplantation Center

Tissue Bank
Department of Corneal Transplantation
Department of Cell Therapy and Transplantation Medicine
Admission and Discharge Center
Perioperative Assessment and Care Center
Clinical Nutrition Center
Swallowing Center
International Medical Center
Center for Epidemiology and Preventive Medicine
Center for International Preventive Medicine
Cancer Board
Vascular Board
Hip Fracture Board
Palliative Care Consulation Team
Nutrition Support Team
Medical Community Network and Discharge Supporting Center
Cancer Resource Center
Patient Relations and Clinical Ethics Center

12

Associate Professor
Hiroko Kanda
Associate Professor
Hiroaki Nozawa
Project Associate Professor Ayumi Yoshizaki
Professor
Minoru Ono
Professor
Haruki Kume
Professor
Kiyoshi Hasegawa
Associate Professor
Masaaki Sato
Associate Professor
Sumihito Tamura
Associate Professor
Takashi Miyai
Professor
Mineo Kurokawa
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor

Kanji Uchida
Hideto Saijo
Kazuhiko Fukatsu
Naoto Kubota
Rumi Ueha
Sumihito Tamura
Nobutake Yamamichi

Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor

Haruki Kume
Masahiko Sumitani
Katsuyuki Hoshina
Takehiro Matsubara
Masahiko Sumitani
Kazuhiko Fukatsu
Masahiko Sumitani
Sachiyo Nomura
Yoshiyuki Takimoto

Clinical Research Services
Clinical Research Promotion Center
22nd Century Medical and Research Center
Department of Tissue Engineering
Cooperative Unit of Medicine and Engineering Research
Translational Research Center
Genomic Reseatch Support Center
Unit for Early and Exploratory Clinical Development
BioResource Center
Center for Brain Imaging in Health and Diseases

Professor
Takashi Moritoyo
Associate Professor
Tatsuya Maruyama
Professor
Yutaka Osuga
Project Associate Professor Miki Iwabu
Professor
Kazuto Hoshi
Project Professor
Atsuhiko Hikita
Professor
Minoru Ono
Professor
Yutaka Osuga
Professor
Yutaka Osuga
Associate Professor
Nobuhiro Shojima
Professor
Takeshi Iwatsubo
Professor
Tetsuo Ushiku
Professor
Katsutoshi Oda
Professor
Kiyoto Kasai

Hospital Management Services
Medical Safety Management Center
Infection Control Center
Office of Performance Monitoring
Department of Highly Advanced Novel Medical Technologies Evaluation
Department of Unapproved New Drugs and Medical Devices Evaluation
Professional Development Center
Clinical Simulation Center
Hospitality Center
Department of Clinical Research Governance
Department of Healthcare Information Management
Department of Medical Record Management
University Hospital Medical Information Network Center
Datebase Center of the National University Hospitals
Labor Safety and Health Management Office
Staff Wellness Consulting Office
Office of Medical Clerical Support for Physicians
Medical Devices Management Center
Department of Disaster Medical Management
Legal and Compliance Office
Center for Liaison and Public Relations
Administration Department

Associate Professor
Professor
Associate Professor
Professor
Professor
Professor
Professor
Professor

Tomotaka Yamamoto
Takeya Tsutsumi
Tomotaka Yamamoto
Haruki Kume
Kazuhiko Fukatsu
Kanji Uchida
Masato Eto
Masato Eto

Professor
Yutaka Osuga
Project Professor
Rika Wakao
Project Associate Professor Yoshimasa Kawazoe
Professor
Associate Professor

Takahiro Kiuchi
Tsuyoshi Okuhara

Associate Professor
Professor
Professor
Associate Professor
Professor
Professor
Professor
Professor

Tomotaka Yamamoto
Kiyoto Kasai
Haruki Kume
Noriko Makita
Kent Doi
Kent Doi
Kanji Uchida
Kiyoto Kasai

13

14

Faculty of Medicine
Graduate School of
Medicine
The University of Tokyo

Graduate School of Medicine

Molecular Cell Biology.............................................. 16
Functional Biology..................................................... 19
Pathology, Immunology and Microbiology.................. 21
Radiology and Biomedical Engineering.......................24
Neuroscience ...........................................................26
Social Medicine........................................................29
Internal Medicine ..................................................... 31
Reproductive, Developmental and Aging Sciences ......35
Surgical Sciences .....................................................37
Health Sciences and Nursing ....................................44
International Health .................................................48
School of Public Health ............................................ 51
Center for Disease Biology and Integrative Medicine...55
The International Research Center for
Medical Education.............................................58
Global Nursing Research Center................................59
Center for Diversity in Medical Education andResearch........................................................... 60
Institution

61

Medical Library
Office of International Academic Affairs
Medical Scientist Training Program
Museum of Health and Medicine
Office for Human Research Studies
Life Sciences Core Facility
The Office for Clinical Practice and Medical Education
Advisory Office for Conflict of Interest

15

A
G
C
T
Molecular Cell Biology

Cell Biology
Our goal to deepen the physical understanding of living cells. Our main
approach is observing the dynamics of the individual molecules in living cells.
For this end, we are also working on the development of the underlying
technologies, including fluorescent and other probes, microscope and otherequipment, analytical techniques using machine learning or physical theories.
Development and application of super-resolution and/or single-molecule
imaging● Development of fluorescent probes to visualize cellular states● Application of machine learning to analyze microscope images● Single molecule measurement of molecular motors under crowding
environments in living cells.
● Measurement of non-equilibrium fluctuation in living cells and explorationof its physiological meanings.
●

Single molecule imaging of kinesin molecules inliving cell.

Structural Biology
Kikkawa lab is interested in eukaryotic flagella/cilia, which works as apropeller and a sensor of cells. We study regulatory mechanisms of flagella/cilia beating by combining cryo-electron microscopy, optical microscopy withhigh-speed camera, cell biology, and genetics. We also provide cryo-electron
microscopes as shared facilities.
Our current focuses are:
● How cilia/flagella are assembled.
● Molecular mechanisms of flagella and axonemal
dyneins.
● Provide cryo-electron microscopy as shared facility

Cryo-electron microscopies installed in the University of Tokyo.
From left to right: Titan Krios G3i (upper left), Talos Arctica (upper right),
Aquilos (FIB-SEM,lower left), JEOL JEM-F200 (lower right).

16

http://structure.m.u-tokyo.ac.jp/

Cytoarchitectonics

http://cb.m.u-tokyo.ac.jp/

Our laboratory aims to study the function of microtubule-based molecularmotors, kinesin superfamily proteins (KIFs). We have previously identified 45
KIF genes from human and mouse genomes. According to mouse molecular
genetics and structural biological analyses, we have identified their functional
relevance in higher brain function, brain wiring, left-right determination,
tumor suppressing pathway, metabolic diseases, and so on. However, there
still exist multiple interesting questions in this field, which we aim to solve by
multidisciplinary and comprehensive approaches.

The neuronal cytoskeleton and its associated organelles（From Nature Milestones 2008）

Cellular Neurobiology
The Laboratory of Cellular Neurobiology is interested in understanding themolecular mechanisms regulating synapse formation and maintenance,
which are essential in proper function of neural circuits in the brain. The
laboratory is using optical imaging of synaptic molecules in live neurons, in
combination with molecular biological approaches to modify neuronal
functions.
Molecular architecture of the postsynaptic density
Molecular mechanisms of activity-dependent synapse remodeling● Regulation of synapse functions by glial cells● Regulation of synapse formation and maintenance in vivo
● Synapse dysfunction in psychiatric diseases●●

Quantitative fluorescence imaging of cultured
hippocampal neurons (green: postsynaptic protein andcalibrated fluorescent microspheres, red: presynaptic
protein, blue: microtubule-associated protein)

Molecular Biology

https://molbiolut.jp/en/

Our laboratory has been doing trans-disciplinary studies
primarily on autophagy, an intracellular degradation
system, and trying to elucidate the mechanisms andbiological and pathophysiological functions of autophagy.
Molecular mechanism of autophagy (membrane
dynamism, lysosomal degradation, selectivity, etc.)● Physiological and pathophysiological roles of
autophagy● Development of new methods for monitoring andmodulating autophagy● Autophagy-independent mechanisms of intracellulardegradation●

17

Genome Informatics

http://www.sg.med.osaka-u.ac.jp/index.html

Our department investigates statistical genetics to translate
multi-layer human omics resources to elucidation of disease
biology, genomics-driven drug discovery, and implementationof personalized medicine. To fully understand the humangenome sequences, a blueprint of humans, we explore theresearch activity by massively utilizing the omics andinformatics analysis technologies.
Large-scale and biobank-scale disease genetic studies
to identify disease risk genes● Exploring new human omics layers such as single celland metagenome analyses● Application of machine learning to large-scale humanomics data and development of novel statisticalgenetics algorithms● Translational research towards implementation of
genomics-driven drug discovery and personalized
medicine

遺伝統計学を主軸に、多彩なヒトオミクス情報のデータ解析を通じた疾患病態解明・ゲノム創薬・個別化医療の実現への取り組み
ゲノム解析の成果をどのように活用すれば病態解明・創薬・個別化医療に貢献できるのか
ほとんどわかっていない

氷山の一角：ヒトゲノム配列のほとんどは未解明●

腸内微生物叢メタゲノム
ショットガンシークエンス

集団ゲノム情報への畳み込み深層学習（DEEP*HLA）

Physiological Chemistry and Metabolism

疾患ゲノム創薬の実装（Trans-Phar）

シングルセル解析による疾患病態解明

http://bio.m.u-tokyo.ac.jp/

We are investigating cellular behavior and signaling mechanisms
underlying cell fate determination, morphogenesis andorganogenesis in embryonic development.
Mechanisms of neural crest fate determination andcraniofacial morphogenesis● Mechanisms of cardiac development● Mechanisms of angiogenesis●

Understanding morphogenesis and organogenesis
based on collective cell movement

Advanced Structural Studies
Our main interest is development of new methods and improvement ofexisting techniques for structure determination by cryo-electron microscopy(cryo-EM). Simultaneously, we are using state-of-the-art cryo-EM to study the
structures of "difficult" samples, such as membrane proteins, small (< 100kDa) molecules, heterogeneous samples and intact cellular volumes.
Cryo-EM is already past the tipping point and is being widely accepted andappreciated as a capable structural biology method. There are several areas
where further progress is expected and/or already ongoing. Instrumentation,
sample preparation, automation, deep learning and streamlining of theresearch process are of great interest to us and we are trying to contribute inthese directions.

The structures of G-protein coupled receptors (upper) andhemoglobin (lower) solved by cryo-electron microscopy

18

http://danevlab.m.u-tokyo.ac.jp/

Functional Biology

Integrative Physiology
The cerebral cortex acquires complicated response selectivity by receiving
and processing information from the outside of the world. However, it is still
unknown what kind of neural circuit actually is involved in this information
processing. In recent years, progress of imaging technology (two-photon
excitation method) has made it possible to simultaneously measure theactivity of thousands of neurons from a living animal (Ohki et al., 2005,
2006). In addition to that, various technologies for studying neural circuits
are being developed one after another and research on neuroscience isentering a transition era. In our laboratory, by using these latest methods,
we are trying to find out how the neural circuits of mammalian visual cortex
process information.

https://physiol1.m.u-tokyo.ac.jp/ern24596/
We clarify the functional unitary circuit, its
operation principle and formation principleof the cortex using two-photon imaging
and optogenetics.

Two-photon imaging

Unitary circuit
Functional Organization

Optogenetics

Elucidation of functional unitary circuitin the cortex
Methods: two-photon microscopy
with single-cell resolutionPeters & Payne 1993	

Formation Principle
Interplay between innate factors
And activity-dependent processes
Methods: Genetic manipulations andOptogenetics

Operation Principle
Information representation and decoding
Methods:9Fast two-photon volume imaging

Functional organization in the visual cortex
Development of neural circuits in the visual cortex● Information representation in the visual cortex● Roles of each cell-type in the processing of visual information●●

Cellular and Molecular Physiology

http://plaza.umin.ac.jp/~Matsuzaki-Lab/

Our laboratory studies the neural circuits in the frontal cortex, which emerge
movement and thought. Applying two-photon imaging, optogenetics, andelectrophysiology to behaving mice and marmosets, we measure andmanipulate the activities of multiple neurons and analyze their dynamics.
Neural circuits for motor learning and motor execution.
Neural circuits for decision making.
● Neural circuits for brain-machine-interface.
● Development of novel fluorescent microscopy system.
●●

Two-photon image ofthe mouse motor cortical neurons

19Neurophysiology
The synapse is a key structure essential for brain
function. We study how synapses work and undergochanges during postnatal development, learning andmemory by recording neural activity in real time. We use
various methodologies including electrophysiology,
molecular biology, and optical imaging of functional
molecules.
Postnatal development of synaptic function andorganization in the cerebellum● Retrograde synaptic modulation mediated byendogenous cannabinoids● Synaptic integration in intact animals● Synaptic plasticity and motor learning in the cerebellum

http://plaza.umin.ac.jp/˜neurophy/〜P3
Purkinje cell

Parallelﬁbers

P12〜P17

P8〜P11

P4〜P7

Strengthened

Translocate

Translocate

Maintained

EliminatedEliminatedClimbing ﬁbers

Synapse formation
Multi-innervation

P18〜

Parallel ﬁber dependent

Functional
diﬀerentiation●

Synapse elimination
Early phase

Late phase

Monoinnervation

P9〜 Climbing ﬁber translocation to dendrite

Postnatal development of climbing ﬁber to Purkinje cell synapses

Postnatal development of cerebellar climbing fiber to Purkinje cell synapses

Cellular and Molecular Pharmacology

http://www.pharmacol.m.u-tokyo.ac.jp/

We aim to elucidate the regulation mechanism ofphysiological functions mainly on the central nervous
system by making full use of our unique fluorescentimaging technique. Currently, we are developing uniquemolecular tag, super-resolution imaging, and calcium
imaging technique by fusing cutting-edge methods suchas chemical biology, organic chemistry, molecular biology,
and optics. By applying these novel imaging techniques toneuroscience research, we are promoting research on themechanism of synaptic transmission in the central
nervous system, mainly focusing on the molecularmechanism underlying releasing neurotransmitters in thepresynaptic terminal.

Systems Pharmacology
We are aiming at understanding of how multi-stability
and homeo-dynamics in sleep-wake systems, as amodel system, can be achieved through regulation ofneuronal firing patterns via protein phosphorylation,and neural circuit structures. Also, we are establishinga high-throughput production platform of geneticallyengineered mice to facilitate a quantitative analysis andperturbation at the organismal level, and paving theway for the basic research by associating with humangenome analysis obtained from human datasets.
Elucidation of the regulatory principle of sleep-wakerhythm● High-throughput production platform of geneticallyengineered/perturbed mice
● Application of human genome analysis from humanstudies to basic research●20

https://sys-pharm.m.u-tokyo.ac.jp/
Organism‐level Systems Biology throughUnderstanding of Sleep‐awake Cycle
Elucidation of the regulatory
principle of sleep‐wake rhythm

High‐throughput platformof genetically engineered mice

Application of clinical studies
to basic research

Advanced Genome &Developmental Engineering

Sleep‐awake cycles in CNS“100% ES mice”“Quantitative” or “Qualitative” Oscillation?

How Sleep‐wake History isRecorded in CNS?

Establishment of F0 Phenotyping
through Non‐invasive Analysis

Verification of the Identified Disease‐related Genes from Human Genome
Analysis by Model Animals

Toward multi‐scale understanding of biological systems, we are planning multi‐scale research
activities based on different backgrounds such as physics, chemistry, informatics, engineering,and medicine, and intercommunicating between foundations and clinics.

Pathology, Immunology and Microbiology

Pathology and Diagnostic Pathology

http://pathol.umin.ac.jp/index_e.htm

Our laboratory performs a wide range of pathology researchusing morphology-based methods along with cutting-edge
technologies, which will lead to earlier diagnosis, more precise
prognosis, and tailored therapy. We are developing nextgeneration diagnostic system and platform with integration of
genomic information and advanced decision-support tools
using artificial intelligence to deliver more accurate diagnosis
and tailored treatment.
●

Hepatoid

Gastric cancer with primitive phenotype

 Increased differentiation plasticity
 Primitive and multilineage phenotype
 Chromosomal instability with TP53 mutation

Pathology Research
●
●
●
●
●

●

Fetal gut-like

Gastrointestinal cancers and others
Primitive phenotypic transformation of cancer cell
Inflammatory conditions of gastrointestinal tract
Neurodegenerative diseases
OthersNext generation Diagnostic Pathology●●●●

Application of machine learning technology
Cancer gene panel testing
3D pathology
Telepathology and Digital Pathology

Molecular Pathology
Epigenetic regulation plays a critical role in cell fatespecification during normal development and stable
maintenance of somatic cell fate. We aim to elucidate theimpact of epigenetic regulation in pathogenesis andorganismal aging. Finally, taking advantage of in vivo
reprogramming technology, we aim to develop
strategies for disease treatment, tissue regeneration, andrejuvenation through epigenetic regulation.
Roles of epigenetic regulation in cancer
Impairment of epigenetic regulation in pathogenesis
and organismal aging● Devising strategies for disease treatment, tissue
regeneration, and rejuvenation with in vivo
reprogramming technologies

Yolk-sac-like

Mesenchymal

Trophoblastic

http://molpathology2.m.u-tokyo.ac.jp/home_E/index.html
Regulation of biological functions at the organismal level
CancerDiabetes

In vivo reprogramming technologies
Tissueregeneration

Aging

●
●

-Mechanisms for tissue homeostasis-Impairment of epigenetic regulation in pathogenesis

Devising strategies for disease treatment,
tissue regeneration, and rejuvenation
Regulation of biological functions at the organismal level21Microbiology

https://microbiology-en.labby.jp

Our laboratory mainly studies respiratory viruses such as
coronaviruses and influenza viruses, with a focus onparamyxoviruses. We aim to contribute to society by
elucidating the molecular mechanisms of viral diseases. We
also aim to contribute to the state-of-art medicine by
developing new technologies related to recombinant virus
vectors.

Activation of Respiratory Viruses by Host Proteases

Molecular Mechanisms of Paramyxovirus Replication andPathogenicity● Mechanism of Activation of Respiratory Viruses by Host
Proteases● Research on the Development of Viral Vectors and their
Application to Vaccine Development●

Cleavage of viral spikes during the virus entry by TMPRSS2(novel coronavirus; SARS-CoV-2)

Brown: viral antigen

Wild-type mouse lung

TMPRSS2 knockout mouse lung

TMPRSS2 is required for replication of influenza andcoronaviruses in the airway epithelium and lungs

Cleavage of viral spikes during synthesis
by furin or TMPRSS2 (paramyxoviruses,
influenza viruses, coronaviruses)

Activation of Respiratory Viruses by Host Proteases

Infection Control and Prevention
We conduct clinical activities aimed at controlling healthcare-associatedinfections. We also conduct research activities targeting viral infections suchas COVID-19 and hepatitis B virus, as well as bacterial infections such as drugresistant bacteria such as MRSA and Clostridioides difficile, which areimportant problems in healthcare-associated infections. We aim to establish apreemptive and total infection control against infectious diseases.
Development of coordinated strategies for the control of healthcare-associatedinfection● Elucidation of acquisition of resistance mechanism of drug-resistant bacteria● Development of measures to prevent endoscopy-related infection● Pathogenesis of Clostridioides difficile enteritis● Development of candidate therapeutics for COVID-19● Genetic analysis of pathogenic microorganisms for nosocomial infection● Investigation and development of control of blood-borne infections during
needlestick injuries● Examination and analysis of environmental microorganisms by monitoring●

Immunology
We aim to comprehensively understand immune responses byanalyzing molecular mechanisms of the development of immune
cells and the regulation of innate and adaptive immune systems,
and to provide novel strategies for the treatment of immune
diseases. We focus on the molecules and immune cells that
contribute to autoimmune diseases, employing geneticallymodified mice to address their physiological significance in vivo.
Animal models for studying immune cells by genome
engineering technology● Molecular mechanisms of immune cell development● Role of immune tissue microenvironment in immune cell
regulation● Mechanisms and pathogenesis of autoimmune diseases● Regulation of bone metabolism by the immune system● Regulation of immune cells in bone microenvironment● Osteoimmunology and stromal immunology●

22

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・0HGXOODU\ILEUREODVWVNitta et al, Nat Immunol 2020

7KHWUDQVFULSWLRQIDFWRU(76JRYHUQVSDWKRORJLFDOWLVVXHUHPRGHOLQJSURJUDPVLQILEUREODVWVYan et al, Nat Immunol 2022

Applied Pathology
We study signaling mechanisms of the TGF-β family
proteins, and elucidate how they regulate progression ofcancers. Mechanisms of regulation of TGF-β-Smad target
genes will be studied by genome-wide approaches.
Based on these findings, we will develop new strategies
for the treatment of cancer.
Dynamic changes in the transcriptional machinery
regulated by TGF-b● Roes of TGF-b in epithelial-mesenchymal transition(EMT)● Roles of tumor microenvironment - approach byorthotopic transplantation models● Analysis of cancer metastasis by tissue-clearing
methods●

http://beta-lab.umin.ac.jp/index.htm
epithelial cells

mesenchymal cells
intravasation

TGF-b
EMT

invasionformation ofmetastatic nichecell adhesion/survival
14 days
MET

extravasation
1 hour

TGF-bmetastatic colony

E-cadherin staining

Multiple functions of TGF-β on metastatic colony formation

Multiple functions of TGF-β on metastatic colony formation

23

Radiology and Biomedical Engineering

Radiology

http://www.ut-radiology.umin.jp/

We have been performing a variety of research studies in biomedical imaging
and analysis, computer-assisted diagnosis (CAD) and radiation therapy.
●

Diagnostic Radiology
●
●
●

●

Radiation Oncology●●●

MRI analysis of brain morphology, diffusion, function and network
Development and application of CAD systems
Simulation of interventional radiology procedures using 3D printing
Stereotactic irradiation by gamma knife, synergy system and intensity
modulated radiotherapy (IMRT)Clinical and biological studies for the reduction of radiation-induced damage

Nuclear Medicine●●

Functional imaging using radioisotope-labeled tracer technology
Imaging of brain metabolism and aggregated proteins using PET
Representative images analyzed with computerassisted technology

System Physiology
We study biomechanics dealing with mechanical phenomena in
the human body, especially focusing on cellular sensing andmechanisms underlying the responses to mechanical stimuli. The
main theme of our work is to elucidate how vascular endothelial
cells sense hemodynamic forces (i.e., shear stress and stretch)
generated by blood flow and blood pressure. This would be of
benefit not only for understanding the blood flow-mediatedregulation of vascular functions, angiogenesis, and vascularremodeling but also for the elucidation of clinically important
problems, such as hypertension, thrombosis, and thedevelopments of atherosclerosis and cerebral aneurysms.

https://square.umin.ac.jp/bme/research_Eng.html
Hemodynamic force
Physiological conditions(Laminar flow)

Pathogenetic conditions(Disturbed flow)

Shear stress

Lo

Stretch

Ld

Plasma membrane

Mechanosensors
Mechanosensors
Ion channel TK receptor
Ca2+
GPCR
Glycocalyx
Ca2+

PECAM-1

TK

Mechanosensing and mechanotransduction
Hemodynamic force-induced cellular responses● Hemodynamic force-mediated gene regulation● Disturbed flow-induced vascular diseases●

24

CaveolaePrimary cilia

Actin filament
NucleusVE-cadherin

●

G

PC1
PC2

Integrin

Endothelial cell

Signal transduction

Homeostatis of
Circulatory system

Vascular diseases
Hypertension, Thrombosis,
Aneurysm, Atherosclerosis.

Chemical Biology and Molecular Imaging

http://cbmi.m.u-tokyo.ac.jp/

Our research group focuses on the design, synthesis, anddevelopment of small molecular chemical probes for biological andmedical research. These include fluorescent probes for visualizing
various events occurring in living cells and animals. We are alsocollaborating with medical surgeons to establish an intraoperative
diagnostic technique by using our fluorescent probes for rapid andsensitive detection of tumor site. Moreover, we are also interested
in developing new therapeutics based on synergistic use offunctional small molecules, proteins, cells, and extracellular
vesicles.
Development of novel fluorescent probes, sensitizers, anti-cancer
drugs, caged compounds, and Raman probes● Biological applications and imaging of functional probes developed
and their use in cancer treatment● Development of next-generation medical technologies bycombining functional proteins, cells, and extracellular vesicles.
●

Integrative Genomics

https://www.h.u-tokyo.ac.jp/patient/depts/genomeshinryou/

Our goal is to achieve clinical application of various types ofgenomic analysis, including cancer and other disorders. We focus
on multi-omic analysis by using clinical samples to develop a novel
cancer genomic profiling test and to establish novel therapeutics
and biomarkers to drug sensitivity. We will also integrate
pathological findings and genomic data, in collaboration with
“ Next-Generation Precision Medicine Development Laboratory”.
Multi-functional Cancer Genomic Profiling：Todai OncoPanel2 (TOP2)EƉĂŶĞů
737 genes^ŽŵĂƚŝĐDƵƚĂƚŝŽŶƐ
'ĞƌŵůŝŶĞ&ŝŶĚŝŶŐƐ
;dƵŵŽƌͲEŽƌŵĂůWĂŝƌĞĚͿ
2 copy
LOH

'ĂŝŶ

^EsƐ
/ŶĚĞů
ŽƉǇŶƵŵďĞƌǀĂƌŝĂŶƚƐ
DŝĐƌŽƐĂƚĞůůŝƚĞ/ŶƐƚĂďŝůŝƚǇ

Clinical application of Todai OncoPanel 2, a novel
cancer genomic profiling test, originally developed
at the University of Tokyo● Standardization of handling of pathological tissue
samples and digital pathology● Genomic/Epigenomic sub-classification of specificcancer types● Drug sensitivity analysis by using organoid
3D-cultures●

ZEƉĂŶĞů
1,390 genes&ƵƐŝŽŶ'ĞŶĞƐ;ϰϲϬ ŐĞŶĞƐͿ'ĞŶĞǆƉƌĞƐƐŝŽŶ
;ϭ͕ϯϵϬ ŐĞŶĞƐͿǆŽŶ ^ŬŝƉƉŝŶŐ

Multi-functional Cancer Genomic Profiling: Todai OncoPanel 2 (TOP2)

Platform for Integrative Genomic Analysis

25

Neuroscience

Neuropathology
Elucidate the pathomechanism of neuronal degeneration and death in major
neurodegenerative disorders (e.g., Alzheimer disease, Parkinson disease), anddevelop novel strategies for disease-modifying therapies.
Mechanism of Ab production, aggregation and clearance
Function of b-amyloid binding proteins (e.g., CLAC)● Mechanism of aggregation and neurotoxicity of a-synuclein● Pathological function of familial Parkinson disease gene LRRK2● Strategies for development and validation of disease modifying therapies for
Alzheimer disease● Mechanism of extracellular release and propagation of tau protein● Pathological function of TDP-43 and FUS in amyotrophic lateral sclerosis●●

Phosphorylated α-synuclein deposited in Lewy
bodies of Parkinson's disease and Lewy body disease

Neurochemistry

http://www.neurochem.m.u-tokyo.ac.jp/

Our brain is able to recognize and memorize external and internal events asthey occur. A functional neural network further stands out by its capacity to
extract patterns and rules, and to associate them with abstract meaning andaffective valence. What are the local and global spectra of the molecularsignaling events in neurons that underlie such complex information
processing at the systems level? Are these events, in turn, converted into
more profound modifications of the synaptic wiring mechanisms? To addressthese issues, we are currently investigating the chemistry and physiology ofvarious neuronal protein complexes near and at synapses.
Understanding molecular and circuit mechanisms controlling memory andemotional behaviors, through integration of state-of-the-art in vitro and in vivo
neurobiological techniques in molecular optogenetics/imaging, geneticalcircuit tracing, and quantitative and behavioral experiments in combination
with genetically modified mice and gene transfer using viral vectors.
● Optical and molecular investigation (including real-time imaging and opticalmanipulation) of biochemical signaling in single synapse, synapse to nucleus,
and living brain circuits that are involved in activity-dependent modification ofneural circuit function and behavior.
●

26

A. Single-synapse imaging (left) and frequencynumber response profile (right) of CaMKIIa andcalcineurin
B. Visualization of migrating neurons (green) andradial glial fibers (red) during corticogenesis
C. Novel object recognition task

Child Neuropsychiatry
Main diseases of our current research are autism spectrum
disorder (ASD), ADHD, Tourette syndrome and childhood
Obsessive-compulsive disorder (OCD). From the viewpointof development of brain and mind, we are trying toinvestigate pathogenesis of these diseases by integrating
phenomenological, neuropsychological, brain-imaging andgenetic studies. We are also applying this integrative approach totreatment research for patients with these diseases.

Examining developmental problems
with symptom dimensions
ADHD

Compulsivity TS

OCD

Impulsivity

ASD
Sociability

Consideration from developmental
viewpoints ― along developmental
trajectory, under interaction withenvironment
Society
SchoolFamilyPuberty

AdulthoodPrimaryschoolInfancy age

Epidemiological, behavior phenotype, neuropsychological,
Multifaceted research based on high quality clinical activities
genetic and treatment study of Tourette syndrome and childhood
Comprehensive
Psychosocial
OCD
Early intervention Parent training forassessment andthose rearing
treatment forfor infants with● Brain-imaging study of ASD, ADHD and Tourette syndrome
psychoeducationofprimaryschoolTourette
ASD and support
adults with● Genomic and epigenomic analysis of ASD and Tourette syndrome
for their parents children with ADHD syndrome (TS)developmental disorders● Development of predictor of pharmacotherapy ad parent training
for ADHD● Effectiveness study of early intervention for autistic preschoolers and support for their parents● Investigation on clinical evaluation and psychological education for adults with developmental disorders●

Neuropsychiatry

http://npsy.umin.jp/en/

Although many psychiatric disorders do not directly cause death, they are known toincur significant reduction of disability-adjusted life years (DALYs) and economic
losses due to their young age of onset, making it essential to elucidate their causes
and establish better treatments. We are conducting longitudinal and integrative
studies of ill-being and well-being in the AYA generation (10s to early 30s), the agegroup with the highest onset of psychiatric disorders. We are combining
neuroimaging, genetic, neuropsychological, epidemiological, and qualitative studies
in patients with psychiatric disorders such as schizophrenia, mood disorders, andneurodevelopmental disorders, as well as in general population cohorts and inanimals.
CAYAC (Comprehensive research for AYA for better mental health Care):
A comprehensive study of the mental health of the Adolescent and Young
Adult (AYA) generation● COCORO (The Cognitive Genetics Collaborative Research Organization):
Investigation of neuropathology of psychiatric disorders using MRI andother multicenter data collected from more than 30 institutions in Japan.
Multi-modality neuroimaging in neuropsychiatry using a combi● Tokyo Teen Cohort: Prospective population-based birth cohort study
nation of high-resolution MRI, EEG, MEG, NIRS, and PET
aimed at investigating physiological and psychological development,
including self-regulation, during adolescence● Research for psychosocial support of AYA generation with 22q11.2 deletion syndrome● Other studies include optical topography, EEG event-related potentials, genetic and epidemiological studies.
●

Neurology
Our Department is conducting research programs to elucidate
the pathophysiological mechanisms of neurological diseases
including neurodegenerative diseases, immune-mediateddiseases and neuromuscular diseases, and to establish newtherapeutic approaches for these diseases. We are also
providing excellent training programs to become a boardcertified neurologist.

https://www.utokyo-neurology.org/
Elucidating molecular basis of neurological diseases anddevelopment of mechanism-based therapy

Molecular basis
gene Adevelopment of mechanismbased therapy
disease modifying therapy

gene Bgene C

neuronal
dysfunction

neurodegeneration．．．

Molecular Genetics (identification of disease genes anddevelopment of therapeutic approaches)● Molecular pathophysiology of neurological diseases (protein
structures and functions)● Immune-mediated diseases (autoantibodies)● Neurophysiology and cognitive neuroscience (magnetic stimulation,
NIRS, MEG, PET, and fMRI)● Neuropathology of neuromuscular diseases (pathological studies
on biopsy and autopsy materials)● Multicenter-based clinical research●

27

Neurosurgery
The 21st century has been designated as "The Century of the Brain". To
lead Japanese surgical neuroscience, we have devoted our activities tothe following: advanced clinical neurosurgery, neuroscience researchand graduate and postgraduate education.
Skull base surgery in managing benign or malignant skull base tumorsand cerebrovascular disorders● Genetic analysis of cerebrovascular diseases and benign brain tumors● Functional neurosurgery including epilepsy surgery● Multi-omics analysis of brain tumors (genetic analysis)● Development of new therapeutic strategies
for malignant brain tumors● Development of novel fluorescence probes for brain tumors● Radiogenomics analysis of brain tumors● Clinical study on gamma-knife surgery● Application of brain functional imaging for neurosurgery● Development of surgical simulation method for AI and XR technology● Cognitive neuroscience using intracranial EEG● Development of brain-machine interface

http://www.h.u-tokyo.ac.jp/neurosurg/
Pre-operative simulation
using 3D-fusion images●

28

Development of brain tumorspecific fluorescent probeSocial Medicine

Preventive Medicine

Exploration of preventive/therapeutic interventions for diseases by genomics & informatics
State-of-the-art analysis of tumor microenvironments
at the single-cell (spatial) resolution Spatial transcriptome information

Antibody drug development using repertoire sequencing
Identification of tumorspecific human antibodies
from tumor tissuesof millions of cells

Clinicalspecimens

・ Antigen discovery
・ Development of therapeutic antibodies
Single-cell transcriptome
information of 100K cells

High-resolution analysis ofcellular interactome withspatial information

Structurization of pathological images and its application
Deep neural network…
...
…

Our goal is to discover appropriate intervention points forthe prevention and therapeutics of human diseases inviews of human health care and hygiene, with special
focuses on malignant tumors, based on genomics andinformation sciences. Using bioinformatics for complex
eco-systems of wide varieties of cells in human diseases(e.g., large-scale genomic information at single cell(spatial) resolution and multi-dimensional
histopathological image information), we have been
exploring preventive/therapeutic targets or biomarkers aswell as analyzing their biological significance in humandiseases.

https://plaza.umin.ac.jp/prm/

input

Machine learning of cell/tissue
segmentation models

Correlation
matrix

𝑮𝑮𝒊𝒊𝒊𝒊= # 𝑭𝑭𝒊𝒊𝒊𝒊 𝑭𝑭𝒋𝒋𝒋𝒋
𝒌𝒌

Deep texture
information(＝painting style)(Cell Rep 2017, Cancer Sci 2023, etc)

Comprehensive genomics to understandcomplex cellular biology in cancer environments
Trans-ancestry cancer genomics(gastric cancer)

Genomic/lifestyle risk factors ofgastric cancers (alcohol/smoking habits)

Transplantation ofpainting style

Gatys et al. arxiv 2017

Quantification of morphological featuresin pathological images

Alcohol-related mutational signatureState-of-the-art analysis of tumor microenvironments at thesingle-cell (spatial) resolution.
Exploration of preventive/therapeutic interventions fordiseases by genomics & informatics● Antibody drug development using repertoire sequencing.
● Structurization of pathological images and its application.
● Comprehensive genomics to understand complex cellular biology in cancer environments.
●

Public Health(Cell Rep 2022, Patterns 2023, etc)

(Sci Adv 2020,
Nat Genet 2023, etc)

https://plaza.umin.ac.jp/publichealth/Public health is the science and art of preventing disease,prolonging life, and promoting health and quality of life
(QOL) through organized community effort. Through studies
in various fields and laboratories, our department aims toadvance research, support policy development, and promote
education toward these ends.
Health services research
Epidemiology of diseases and injuries● Health impact of the COVID-19 pandemic●●

Physician distribution by municipality in Japan

29

Forensic Medicine

http://ut-forensic.jp

We conduct autopsies, and various examinations including histology,
biochemistry, radiology, toxicology, and genetics as usual practices. We also
perform the following research with other institutes and departments
including Education and Research Center of Legal Medicine, Chiba University,and Department of Forensic Medicine, School of Medicine, International
University of Health and Welfare.
Application of imaging modalities such as CT
and MRI for death investigation● Age and stature estimation and sex
determination using CT● Biomechanical properties of human tissue● Diagnosis of drowning● Research for infectivity of SARS-CoV-2 indecedents● Analysis and pathophysiology of illegal drugs
including new psychoactive substances● Application of relatively new DNA testing
method for practice of forensic medicine●

Biomedical Informatics

Forensic autopsy room

CT room

http://www.m.u-tokyo.ac.jp/medinfo/

The Department of Biomedical Informatics aims to reform medical
systems and make social contribution by applying information
technology to medical and clinical field including hospital
information management. The department develops innovative
methods that are applicable to medical information systems in theboundary area of healthcare and information science, establishes
infrastructures for information environment, and applies knowledge
and technique acquired through these efforts to medical andhealthcare field.
The main keywords are medical and clinical information systems,
next-generation electronic health record systems, virtual health careenvironment, AI, natural language processing, machine learning,mHelath, and digital therapeutics.
Development and application of clinical ontology
Automatic Mapping from Clinical Case Dara to
Knowledge of Disease Transition
Sharing healthcare data among medical institutions and theapplication for clinical epidemiology● Extraction of medical knowledge from electronic medical record database using natural language processing● Development of knowledge-driven real time alerting system in clinical practice● R&D of medical artificial Intelligence, mobile health and digital therapeutics●●

30

Internal Medicine

Cardiovascular Medicine

https://cardiovasc.m.u-tokyo.ac.jp/

We aim to provide the finest medical care for all cardiovascular diseases, including heart failure, ischemic heart disease,arrhythmia, valvular disease, structural heart disease, pulmonary hypertension, adult congenital heart disease, and arterial
diseases. In particular, we have treated the largest number of patients with serious heart failure in Japan. In collaboration with the
Department of Cardiovascular Surgery, we would like to work as the last bastion against heart failure. Moreover, with ongoingbasic research and translational studies, we are developing new diagnostic modalities and treatments for refractory diseases.
Investigation of disease pathophysiology (severe heart failure, arrhythmia,
pulmonary hypertension, etc.) and development of novel therapies● Analysis of genome, epigenome, and transcriptomes in various
cardiovascular diseases● Investigation of pathophysiology of cardiomyopathy using iPS cells● Research on the role of chronic inflammation in the pathogenesis of various
cardiovascular diseases● Epidemiology and prevention of cardiovascular disease● Artificial Intelligence in cardiology● Improvement of imaging techniques (echocardiography, MRI, CT, SPECT) for
cardiovascular diseases● Clinical research of severe heart disease, pulmonary hypertension,arrhythmia●

Respiratory Medicine
The number of patients with pulmonary diseases is increasing. At the
Department of Respiratory Medicine, we conduct a wide variety ofbasic and clinical research. We focus on molecular analysis of lungdiseases to develop novel treatment strategies.

http://kokyuki.umin.jp/
Research
Mouse model of NSCLCEGFR L858R

BedsideEGFR-TKI

Molecular profiling of lung cancer● Discovery of novel prognostic biomarkers in lung cancer● Targeted clinical sequencing of lung cancer specimens● Clinical research using the lung cancer database● Molecular analysis of COPD using animal models● Molecular analysis of asthma● Molecular analysis of pulmonary fibrosis using animal models● Clinical epidemiology using the DPC database● Case reports●

Benchside
ALK-TKI

Genetics
Immunology

EMT

Respiratory
diseases

Mouse model of SCLC
inactivation of Rb1 and Trp53

Epigenetics

Stem cells

Non-coding RNAs

31

Gastroenterology

http://gastro.m.u-tokyo.ac.jp/med/home.html

Our Department of Gastroenterology is one of the top institutions in the world in
the treatment of hepatocellular carcinoma by unique ablation(RFA) andgastrointestinal/pancreatobiliary cancer/stone by endoscopic manipulation(ESD&ERCP). The goal of our department is to accurately diagnose and give thebest available treatment to these patients, and to this end, we are performing awide variety of basic as well as clinical research.
Development of better therapeutic strategy for hepatitis B and C
Elucidation of hepatocarcinogenesis mechanism in viral hepatitis● Development of a better therapeutic modality for hepatocellular carcinoma& metastatic liver tumor● Elucidation of gastric injury mechanisms by Helicobacter pylori● Elucidation of stem cell and carcinogenic mechanism of gastrointestinal cancer● Development of therapeutic strategy for advanced pancreatobiliary cancer● Development of a better endoscopic therapeutic modality for pancreatobiliary
cancer/stone● Development of better diagnostic & therapeutic strategy for chronic pancreatitis● Development of an endoscopic en bloc resection method for early gastric, esophageal and colonic cancer● Elucidation of the mechanisms of metabolism-associated liver diseases● Development of better diagnostic & therapeutic strategy for small intestinal diseases●●

Nephrology / Endocrinology

http://www.todai-jinnai.com/

We are investigating the pathophysiology of renal and endocrine
disorders for the development of innovative diagnostic and therapeutic
tools.
Analysis of pathophysiology and development of therapy of chronic kidneydisease● Abnormal oxygen metabolism of kidney disease● Epigenetic changes in CKD● Development of biomarkers and therapy of acute kidney injury● Renal physiology and morphology● G protein signaling in health and disease● Clinical and basic investigation of bone and mineral disorders● Pathophysiology of hypertension● Development of novel telemedicine●

Nutrition and Metabolism
We are investigating to reveal the molecular mechanisms underlying the development of metabolic diseases (diabetes
mellitus, lipid metabolic disorders, obesity disease, sarcopenia, metabolic syndrome and atherosclerosis) using
interdisciplinary approaches and state-of-the-art technology including genetically engineered model animals, iPS cells,
omics analyses (epigenome, metabolome etc), human genetics, clinical epidemiology and bioinformatics. Our major goal
is to develop mechanism-based fundamental treatment and prevention strategies for the metabolic diseases.
●

Elucidation of molecular mechanism of insulin resistance linked to obesity,

sarcopenia and development of novel treatment focusing on AdipoR,
myokines etc

Genetic engineering
Development ofbest-in-class medicine
Animal model
Based on 3-D structure

Functional analyses by
iPS and genome editing

Epigenetic analysis of the mechanisms of metabolic control and their disruption
Liverin type 2 diabetes and obesity
Brain● Elucidation of the molecular mechanism of metabolic diseases and
IoT,AI, ICT
Spleendevelopment of novel treatment using iPS cells
Gut
Immunemicrobiota● Molecular mechanism of insulin signal transduction
Bioinformatics● Molecular mechanism of insulin secretory defect in type 2 diabetes
Vasculature
Adipocytes
Intestine● Genetic susceptibility and risk factors of type 2 diabetes
Human genetics● Using IoT, AI, development of accurate diagnostis, prevention, treatment
algorithm for type 2 diabetes
MuscleTranscriptome
Metabolome● Molecular mechanism of adipogenesis and obesity
Genome Epigenome
GWAS● Transcriptional regulation of lipid metabolism
Integrated analyses● Molecular mechanism of atherosclerosis● Mouse genetic models of diabetes, lipid metabolism disorder and atherosclerosis●

http://www.fasteris.com/images/GAII.png

32

Hematology and Oncology

http://www.u-tokyo-hemat.com/

We investigate the pathogenesis, diagnostic methods, and novel therapeutics of hematological diseases by the comprehensive
use of research technologies in molecular biology, cellular biology, developmental engineering, and genomic science. Studies
about transcriptional regulation and signal transduction in hematopoiesis and analyses of regulation of hematopoietic stem cells
Elucidation
the genomic
and molecularmechanisms medicine, immunotherapy andare promoted. We also implement basic and clinical studies
basedofon
genomics,
regenerative
underlying hematopoiesis and leukemogenesis
transplantation medicine, which aim at application totherapeutic strategies.
Mechanisms in the regulation of self renewal anddifferentiation in hematopoietic stem cells● Comprehensive genomic and epigenetic analysis ofhematological malignancies● Elucidation of the molecular mechanisms underlying
the pathogenesis of leukemia● Development and analysis of mouse models of
leukemogenesis● Regenerative medicine and pathogenesis study
based on human iPS cell technology● Adoptive immunotherapy with T cells engineered
with chimeric antigen receptor or T cell receptor forcancer●HSCs expansion by RUNX1
abnormality in mice

Aberrant hematopoiesis causedby endocrine abnormalities

Molecular ・cellular biology, anddevelopmental engineering

iPS technology-based studyof regenerative medicine andpathogenesis
Elucidation of a specific marker
of leukemia stem cell

Elucidation of a responsible gene and clonal
evolution of familial platelet disorder

Comprehensive analysis of genomic,transcriptional, and epigenomic
aberrations in human samples
Single cell analysis

Elucidation of a responsible
gene and functional analysis in
familial MDS

Epigenetic analysis ofleukemia-relative genes

Elucidation of the genomic and molecular mechanisms underlying hematopoiesis andleukemogenesis

Allergy and Rheumatology
The primary aim of our department is to provide best care and support to patients with rheumatic disease. It is our mission
to provide excellent clinical care while seeking to better define the causes, stratification of patients, and best treatment
approaches for rheumatic disease. To this end, we have to clarify the mechanisms for autoimmunity seen in rheumatic
disease. We perform basic and clinical research to translatelaboratory findings into novel therapeutic approach by combining
genetics, transcriptome informatics and immunology (Ota M et al.
Cell. 2021; Nakano et al. Cell 2022). We think research of humanimmunology in collaboration with patients is the key to overcome
rheumatic disease.
Genome/transcriptome analysis of immunological diseases
Disease classification and diagnosis with genome/transcriptomeof immunological diseases● Pathogenic T cell analyses in autoimmune diseases● Identification of molecular pathway related to prognosis in SLE● Identification of molecular pathway related to prognosis inpolymyositis/dematomyositis● Identification of molecular pathway related to prognosis insystemic sclerosis● Molecular analysis using conditional knockout mice
● Molecular analysis using iPS cells●●

Infectious Diseases
Our main research subjects are viral infections such as HIV, hepatitis viruses,
and SARS-CoV-2, as well as bacterial infections and opportunistic infections.
We conduct basic and clinical research on various pathogens, host immune
responses, and mechanisms of multidrug-resistant bacteria as well as
antimicrobial stewardship. Based on these results, we are also developing
new strategies of prevention, diagnosis, and treatment for infectious diseases.
Treatment and prevention of viral hepatitis
Clinical studies of HIV infection● Molecular pathogenesis of hepatocellular carcinoma in HCV infection● Molecular pathogenesis of hepatitis B viral infection● Pathogenesis of influenza viral infection● Molecular epidemiology and pathogenesis of bacterial infection● Host defenses to microorganisms● Mechanism of multi-drug resistant microorganisms● Promotion of antimicrobial stewardship●●33http://psmut.umin.ac.jp/

Stress Sciences and Psychosomatic Medicine
The targets of our laboratory include stress-related diseases such as primaryheadaches and lifestyle-related diseases, eating disorders and malignancies.
The goals of our work are to determine the mechanisms of these conditions,to develop objective markers for diagnosis and severity, and to discover new
treatment approaches using ecological momentary assessment (EMA),
Ecological Momentary Intervention (EMI), and physiological assessment ofautonomic nervous function.
We are using ecological momentary assessment (EMA) techniques tocollect and evaluate subjective and objective data including physicalactivity and autonomic nervous function in natural settings in stress-relateddiseases. We are also developing new treatments using these methods
called "Ecological Momentary Intervention (EMI)".
● Investigation into the pathophysiology, psychopathology andneurobehavioral basis of stress-related diseases by use of ecologicalmomentary assessment methods● Using heart rate and blood pressure variability, we are investigating
autonomic nervous function in eating disorders. This work uses non-linear
analyses such as fractal analysis, as well as linear analysis.
● We have developed an egogram questionnaire, which we refer to as the
TEG.
●

Clinical Laboratory Medicine

http://lab-tky.umin.ac.jp/

The main goal of our research projects is the development of new and useful laboratory tests, and elucidation ofpathophysiology of diseases through laboratory tests.
(Patho)physiological roles of lipid mediators, and its application tolaboratory medicine● Introduction of mass spectrometry into clinical laboratory practice● Cancer genomic medicine using next generation sequencing● Clinical introduction of the assay of oxidized albumin and the novel
laboratory diagnosis in thrombosis and hemostasis● Neuroscience research using magnetoencephalography and noninvasive brain stimulation● Echocardiographic studies of the pathophysiology of valvular heartdisease and the hemodynamics● Promotion of medical-science-engineering cooperation●

Clinical Laboratory Medicine
Analysis of lysophospholipids
with mass spectrometry

Department of Clinical Laboratory (Hospital)

Transfusion Medicine
The Department of Transfusion Medicine aims the achievement ofsafe and appropriate transfusion practice in the hospital, and forthis purpose, controls, tests and supplies all blood products fortransfusion.
The research fields include:
Detection of red cells/ leukocytes/platelets antigens/antibodies
Investigation on the pathophysiology of the immunologicaladverse effects of transfusion● Clinical study for the safety of autologous blood donation●●34

http://square.umin.ac.jp/traf-tky/Reproductive, Developmental andAging Sciences

Gynecologic Oncology

https://www.h.u-tokyo.ac.jp/english/centers-services/clinicaldivisions/gynecologic-surgery/index.html

We perform basic research focusing on genetic and epigenetic analyses in gynecologic oncology to establish novel
diagnostic and therapeutic tools. In the clinical aspects, we provide life-long medical care for the patients with endometriosis
and/or adenomyosis and perform advanced gynecologic surgeries such as adenomyomectomy and radical trachelectomy.
We actively perform endoscopic and robot-assisted surgeries in gynecologic oncology.
Optimization of surgery for fertility preservation in
endometriosis, adenomyosis and uterine fibroid● Minimally invasive surgery (laparoscopic and robotassisted surgery)● Genomic medicine in hereditary gynecologic cancers● Development of diagnostic / therapeutic methods forgenomic and epigenomic analyses● Development of novel therapeutic tools to target DNA
repair pathway● Development of new gynecologic medical system using
artificial intelligence●

Somatic KRAS mutation in adenomyosis

Molecular and Cellular Reproductive Medicine
We investigate the molecular mechanisms of reproductive functions
using the knowledge and techniques of molecular and cellularbiology and genetics.
Our studies are focusing on the pathophysiological mechanism of sex
steroid hormones to elucidate how these hormones effect on
reproductive phenomena including embryogenesis, spermatogenesis
and fetal development, and on the prenatal genetic diagnosis.
Effect of sex steroid hormones on reproductive medicine
Molecular mechanisms of embryogenesis● Analysis of implantation mechanism● Pathophysiology of ovarian aging and elucidation of its mechanism● Molecular analysis of follicular atresia●●

Molecular mechanisms of sex steroids

35

Pediatrics / Developmental Pediatrics

http://square.umin.ac.jp/ped/

We are actively engaged in medical care, education, and research on various pathological conditions and social issues ofchildren.
Molecular diagnosis and analyses of hematologic diseases and solid tumors
Clinical studies on leukemia and solid tumors● Molecular diagnosis, analysis and collaborative treatment of pediatric renal diseases● Molecular analysis and diagnosis and collaborative treatment of endocrine/metabolic diseases and diabetes● Diagnosis, molecular analysis and collaborative treatment of congenital
heart diseases● Molecular mechanism of Neonatal immune tolerance● Comprehensive analysis of biomarkers in neonatal diseases● Microbiome and immune function in neonates● Immunity of neonates born to mothers with systemic autoimmune
diseases● Neurocognitive effects of intrauterine infection and environmental toxins● Diagnosis and comprehensive treatment of neuromuscular disorders● Molecular diagnosis and treatment of mitochondrial disorders● Early intervention of developmental disorders● Patho-physiological analysis by digital data in pediatric critical care
● Protective respiratory care by trans-pulmonary pressure in children● Development of educational program of transitional care●●

Pediatric Surgery
Pediatric surgical diseases have great variety. In our department allkinds of pediatric surgical conditions are treated, and in these fetal
and neonatal surgical care is our main interest. We also treat many
pediatric patients using minimally invasive surgeries such as
laparoscopy and thoracoscopy.
Fetal surgery and treatment
Pediatric minimally invasive surgery● Pediatric robotic surgery● Biliary atresia and biliary dilatation: their treatment and long-term
prognosis● The treatment by regenerative medicine of air way malacia andstenosis● Development of pediatric surgical models● Association between pediatric surgical diseases and intestinal
microbiota● Assessment of pediatric surgical procedures using nation-wide data●●

Geriatric Medicine

EXIT(ex utero intrapartum treatment):
Tracheostomy on a fetus with laryngeal atresia

https://www.h.u-tokyo.ac.jp/patient/depts/rounen/

The Department of Geriatric Medicine, established in 1962, is the firstdepartment of Geriatric Medicine in Japan. The staff physicians arehighly trained and experienced in managing complex cares.
Comprehensive cares including assessment and treatment of chronic
diseases, geriatric conditions, and frailty are provided to ensure qualityof life and health in older patients. Our research interests are as
follows:
Molecular mechanisms of vascular calcification
Molecular mechanisms of sarcopenia● Inhibition of cognitive decline using antihypertensive drugs● Cares and burdens of family caregivers of patients with dementia● Risk factors for adverse drug events● Association of sex hormones and vitamins with geriatric conditions● Novel gene responsible for locomotive syndrome, including
osteoporosis● Molecular mechanisms of vascular injury in sleep apnea syndrome● Polypharmacy and frailty●●

36

A アルツハイマー型認知症の頭部MRIと脳血流SPECT
typical brain MRI image and a brain perfusion SPECT image of an
Alzheimer's disease patientSurgical Sciences

Thoracic Surgery

http://cts.m.u-Tokyo.ac.jp

We specialize in surgical treatment and oncology for thoracic
malignancies including primary lung cancer, pulmonary metastasis andmediastinal tumors. We are conducting a wide range of research from thedevelopment of cancer immunology to minimally invasive surgicalmethods such as thoracoscopic/robot-assisted surgery.Since 2014, The
University of Tokyo Hospital has been certified as the sole lung transplantinstitute in Tokyo. Since 2020, the annual number of lung transplants
performed has become the highest in Japan. We are conducting clinicalresearch on lung transplantation and basic research using animal models.
Minimally invasive therapeutics for chest malignancies
Clinical and basic oncology of lung cancer and thymic epithelial
neoplasms● Clinical and basic research on lung transplantation●●

Cardiovascular Surgery

http://cts.m.u-tokyo.ac.jp/cardiac-surgery

We are leading in Japan by annual surgery case volume of 400. New
knowledge and techniques are actively applied clinically. We are aggressively
performing ventricular assist device implantation and heart transplantationfor end-stage heart failure, mitral valve plasty, valve-sparing aortic root
replacement, curative surgery for active endocarditis, and surgery forcomplex congenital heart disease. Many clinical research projects are goingon along with routine clinical activities. Our laboratories have been also
carrying out a large variety of basic research.
●

Clinical research
●
●
●
●
●

●

Improvement of long-term results of heart transplantation
ventricular assist device for end-stage heart failure
valve plasty and valve-sparing operation
Minimally invasive surgery
Treatment of complex congenital heart disease

Basic and experimental research●●●

Development of new control system for ventricular assist device
Development of myocardial regenerative therapy
Development of a new suture device under endoscopic environment

37

Gastrointestinal Surgery

http://gibes.m.u-tokyo.ac.jp/

Our goal is to cure the cancer patients by much better surgery. The development of better surgical methods have the highest
priority. Better surgery means radicality of the cancer, minimal invasiveness, and good QOL after surgery. Recently, robot assistedtransmediastinal (non-transthoracic) radical esophagectomy has been developed, which shows less postoperative pulmonary
complications and better QOL after surgery compared with conventional esophagectomy.
●

Cure by much better surgery
●
●
●

●

●

Robot assisted transmediastinal esophagectomy for esophageal cancer
Robot assisted gastretomy for gastric cancer
Laparoscopic endoscopic cooperative surgery (LECS) for gastric andduodeneal tumor, non-exposed endoscopic wall-inversion surgery (NEWS)for gastric tumor
Laparoscopic gastrectomy for function preserving (proximal, distal andpylorus preserving gastrectomy)

conventional

Research for carcinogenesis, progression, diagnosis and treatment
●
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Inflammation and gastrointestinal carcinogenesis
Activatable fluorescence imaging probe for esophageal and gastric cancer
Oncolytic viral therapy for esophageal cancer
Genetics and epigenetics for esophageal and gastric cancer
Early detection of gastrointestinal cancer by new biomarkers
Immunotherapy based on intratumoral immune response in gastric cancer

Hepatobiliary Pancreatic Surgery

transmediastinal (non-transthoracic)

http://www.u-tokyo-hbp-transplant-surgery.jp/

We perfom approximately 150 hepatectomies in patients with hepatobiliary
malignancies and approximately 90 pancreatectomies in patients withpancreatic neoplasms every year. The first priority is put on the safety of thepatients undergoing surgery. In order to improve the surgical outcome forhepato-biliary-pancreatic diseases, we conduct wide variety of research
including analysis of prognostic factors for liver malignancies, intraoperative
diagnostic tools, liver ischemia/reperfusion injury, and liver regeneration.
ICGfluorescent imaging for detecting tumors

The analysis of genetic abnormalities in hepatocellular carcinoma
Development of new methods for the evaluation of liver functional reserve● The evaluation of hemodynamics in the congested liver using ultrasonography● Navigation system during liver surgery● Intraoperative diagnosis using ICG fluorescent imaging● Clinical trials concerning perioperative chemotherapy in hepatic resection forcolorectal liver metastasis● Clinical trials addressing utility of preoperative drug therapy for hepatocellular carcinoma● Vascular reconstraction using criopreserved vein grafts Evaluation of the anti-adhesionmaterials● Development of new artificial vessels dedicated for HPB surgery● Development of anti-adhesion materials●●

Urology

Vascular reconstraction using
criopreserved vein grafts
Preoperative 3D imaging of
the liver constructed bysimulation software

http://square.umin.ac.jp/UT-urology/

We perform more than 1,500 urological surgeries every year, including nephrectomy, cystectomy and prostatectomy, withincreasing trend of laparoscopic maneuvers. Robotic surgery was introduced in 2011. Surgical or non-surgical procedures are
employed for non-cancer disease including chronic renal failure, urinary dysfunction, urinary incontinence and interstitial cystitis.
Genome analysis of renal cancer, renal pelvic cancer, ureteralcancer and testicular cancer● Genome analysis of Corticotropin-independent Cushing’s syndrome● Pathogenesis of interstitial cystitis● A prospective randomized controlled study on the suppression ofcancer● Artificial urinary sphincter for male urinary incontinence● Robot-assisted laparoscopic surgery (prostate, renal, and bladdercancer) (Fig.1)● Immune checkpoint inhibitor for metastatic renal cancer andbladder cancer● Multidisciplinary treatment for locally advanced prostate cancer● Site-directed therapy for oligometastasis of prostate cancer● Salvage robot-assisted radical prostatectomy after radiotherapy● Surgery for chronic renal failure (hemodialysis, peritoneal dialysis
and renal transplantation)● Urogynecology (pelvic organ prolapse)●

38

Fig.1 Surgical scene of Robot-assisted laparoscopic radical prostatectomy

Artificial Organ and Transplantation Division

http://plaza.umin.ac.jp/htokyotransplant/

798 living donor liver transplantation and 64 deceased donor livertransplantation until Dec. 2022. The 5-year survival rate for adult case was 88%,
which is significantly superior to that of the national data (73%).
Surgical technique of liver transplantation: including
right lateral sector graft, APOLT(Auxillary partial
orthotopic liver transplantation)● Hepatic vein reconstraction using criopreserved vein
grafts● Identification of veno-occlusive resions using ICG
fluorescence imaging● Antiviral treatment for hepatitic C and B virus infection
after liver transplantation● Novel strategies in liver transplantation for PBC and
PSC● Expansion of liver transplant indication for HCC● Diagnosis and treatment for acute rejection● Diagnosis and treatment for postoperative infection●

Overall survivals after living donor liver trasnplantation

Hepatic vein reconstraction using
criopreserved vein grafts

Surgical Oncology

http://all-1su.umin.jp/

We have performed basic and clinical research mainly on colorectal cancer
and inflammatory bowel disease. In basic research, we are studying biologicalphenomenon from various point of view such as carcinogenesis, cancer
metastasis, and immunology. In clinical study, we are trying to identify thebest way to treat each patient with the least surgical stress by minimallyinvasive surgery such as laparoscopic surgery and robotic surgery (da Vinci),and preoperative chemoradiation therapy for rectal cancer.
Robot assisted surgery (da Vinci robotic surgery)● Radiosensitivity and chemosensitivity of cancer● Characterization of tumor vasculature and its therapeutic
application● Surveillance of ulcerative colitis● Carcinogenesis in ulcerative colitis● Cancer and autophagy● Development of chemoradioimmunotherapy● Genetic analysis of poorly differentiated colorectal cancer● Intraperitoneal chemotherapy for peritoneal carcinomatosis●

Fig.1 Prediction ofchemoradiosensitivity
in rectal cancer by
DNA microarray
Fig.2 Targeted vsrandom biopsies forsurveillance ofulcerative colitisassociated cancer

Vascular Surgery

http://vascular-1su.jp/en/

We have a great deal of experience in treating patients with various
vascular diseases, and we have performed much research on
atherosclerosis, angiogenesis and vascular regeneration. Based on
the research results, we are trying to identify the best way to treat
each patient with the least surgical stress.
Development of a novel method to diagnose and treat thevasculardiseases.
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●

Vascular regeneration therapy for atherosclerotic obliteransDevelopment of aortic aneurysm model and simulation
Gene analysis of peripheral arterial disease
Visualization of the atherosclerotic lesions with fluorescent probe
Navigation system for less invasive vascular surgery
Analysis of intermittent claudication with dynamic and mechanicalmodel
Dynamic and genetic mechanism of aortic aneurysm expansion
Development of the new prosthesis with small diameter
Hemodynamic analysis of aortic wall after endovascular aneurysm
repairDrug delivery system for aortic aneurysm and peripheral arterial
disease39

Breast and Endocrine Surgery

http://todai3ge.umin.jp/

Clinical activities in the department of breast and endocrine surgery widely range from diagnosis to surgical treatment forbreast cancer, thyroid cancer, and benign tumors of breast, thyroid, and parathyroid. We also place importance on medical
genetics including hereditary breast and ovarian cancer syndrome (HBOC) as well as precision medicine based on cancer
genome information. Our goal and motivation of basic
research are to eradicate metastatic breast cancer inwhich complete cure has yet to be realized.
BRCAness in triple negative breast cancer
Use of droplet digital PCR for quantitative andautomatic analysis of the HER2 status● Detection of the PIK3CA mutation in circulating tumor
DNA in early-stage breast cancer● Impact of CDK4/6 inhibitor palbociclib on activinSMAD2 signaling in estrogen receptor-positive breast
cancer● Stem-like cells of breast cancer● Epigenetic change which is critical for carcinogenesisof breast cancer● Big data analysis in oncology●●

The immunohistochemical features of BRCA1, AR, p53, CK5/6(One patient with a BRCA1
The immunohistochemical features of BRCA1, AR, p53, CK5/6 (One patient with a BRCA1
promoter-methylated
tumor and two patients with a BRCA1 promoter-unmethylated tumor)
promoter-methylated tumor and two patients with a BRCA1 promoter-unmethylated tumor)

Dermatology

http://www.h.u-tokyo.ac.jp/der/Our department actively performs the following cutting-edge, multifaceted
research projects that will be put into clinical practice in the future.
Molecular mechanisms of immunological abnormalities and skin and lungfibrosis in systemic sclerosis● Development of novel therapies to systemic sclerosis, including B cell
depletion therapy● Relative contribution of various cell adhesion molecules and chemokines toinflammatory conditions● Identification of novel autoantibodies and their clinical significance inconnective tissue diseases● New roles of B lymphocytes, especially regulatory roles, in inflammatory
disorders● Immune-epidermal abnormalities in psoriasis and atopic dermatitis● Epigenetic regulatory mechanisms in skin diseases● Roles of chemokines and stimulatory molecules in cutaneous lymphoma● Roles of lipid enzymes and receptors in immune-mediated skin diseases● Largest clinical studies on systemic sclerosis in Japan●

Skin fibrosis induced by bleomycin(left) is inhibited in
CD19-deficient mice(right)

Plastic and Reconstructive Surgery
We aim to develop innovative therapeutic interventions for themorbidities associated with plastic and reconstructive surgery. With avariety of state-of-the-art approaches such as gene therapy andmicrovascular surgery, we continuously work on the reconstruction ofskin, fat, muscle and nerve to fight against the intractable diseases.
●

Clinical Research
●

●

●

●

●

Development of a novel reconstruction method for facial nerve palsy
and its optimization
Standardization of reconstruction method for eye closure in patientswith facial nerve palsy by evaluation of blink function
Evaluation of effectiveness of lymphatico venous anastomosis in earlystages of lymphedema
Research on dysphagia after tongue reconstruction after cancer resection

Basic Research
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40

V-shaped long LD muscle transfer for smile reconstruction

Development of gene therapies for the intractable diseases in plastic surgery
Realization of the innovative therapies for cutaneous ulcers via direct cellular reprogramming
Development of the method for perfect tissue regeneration via tissue embryonization
Elucidation of pathology of vascular anomalies
Development of new therapeutic intervention for alopecia

Oral and Maxillofacial Surgery

http://plaza.umin.ac.jp/~oralsurg/

Our laboratory has been performing a wide range of clinically oriented research in oral-maxillofacial disorders suchas congenital diseases, jaw deformities and tumors in the oral
region. Cartilage and bone regeneration using tissue engineering
techniques is our main field of research.
●

Clinical research:

Treatment of facial deformities and malocclusion in patients with cleft lip/palate
Research on facial growth in patients with craniofacial anomalies Reconstructionof oral and maxillofacial area by custom-made artificial bone (CT bone) (clinical trial)
Transplantation of implant-type tissue-engineered cartilage for cleft lip-nose
patients (clinical study) QOL study of oral health care system in preoperativecancer patients
Overcoming eating loss (eat-loss) The association between oral disorders andsystemic diseases Development of surgical assisted systems using artificial
intelligence, computer vision, and augmented reality
Research on the treatment of temporomandibular joint disorder using autologous
adipose-derived mesenchymal stem cells
●

●

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Temporomandibular joint
Osteoarthritis of
Temporomandibular
joint

●

●

Basic and experimental research:

Regeneration of bone and cartilage with tissue-engineering approach Molecularbiology of cartilage repair and its application to cartilage regenerative medicine
Development of novel scaffolds for cartilage and bone regeneration In vivo
evaluation of tissue-engineered cartilage and bone Study on the control of mesenchymal cell differentiation Elucidation of epigenetic
abnormalities in oral cancers and oral premalignant lesions Functional analysis of microRNAs in human dental pulp stem cells Study on thecleft lip and osteonecrosis of the jaw using animal models Elucidation of mechanisms of tissue repair by adipose-derived stem cells andmacrophages Analysis of regulatory mechanisms of bone using a reconstitution system of the cellular network in bone metabolism●●●

Autologous
adipose-derived
stem cells

●

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Orthopaedic Surgery

http://www.u-tokyo-ortho.jp/

Our department was established in 1906 as the first department oforthopaedic surgery in Japan. Since then our efforts have been dedicated toresponding to the needs of patients for orthopaedic care and to related
research. Our department seeks to elucidate the molecular and genetic
backgrounds of bone and cartilage disorders in order to develop
groundbreaking treatments for these conditions. At the same time, we areattempting to establish various clinical devices.
Systemic and comprehensive study for osteoarthritis
Regulation of bone metabolism and Molecular mechanism of osteoclastdifferentiation● Regenerative medicine of joint and nerve by adipose-derived stem cells and related
technology● Surgical navigation system with a three-dimensional display and navigation robot● Long-life artificial joint by construction of a super-durable lubricious interface of MPC● Prevention of adhesion after tendon repair by hydrogel technology● Artificial Intelligence to predict bone mineral density through plain X-ray●●

Ophthalmology
Our department applies cutting-edge technologies and knowledge todiagnosis and treatment of eye diseases. We conduct basic researches
involving multi-faculties with molecular biological, immunological, andpharmacological techniques, and clinical studies with epidemiology andbiostatistics.

https://www.todaiganka.jp/

Surgery techniques
Neuronal Cell Death

Physiological studies on vision and eye movements
Development and evaluation of new drug therapies and surgical techniques
OCT images
on glaucoma, or retinal, corneal, and uveal diseases.
● Development of diagnosis and treatment in glaucoma with functional andstructural analysis.
Surgery Training System● Study on mechanisms for maintaining intraocular pressure, andＴＧＦＢＩ genedevelopment of new drugs using clinical samples of glaucoma eyes andgenetically modified animals.
● Further research in the mechanisms of neuronal death in retinal neurons and glial cells, and exploration of usefulneuroprotective agents.
● Development and application of surgery training systems with bionic eyes.
● Improvements in corneal regeneration therapy and development of new therapies in hereditary corneal diseases.
● Study on corneal mechanisms to maintain clarity.
● Research on refractory uveitis and intraocular lymphoma.
● Comprehensive studies on multimodal imaging of structures and functions of macular diseases.
●●

Human TGFBI gene41

Otolaryngology and Head and Neck Surgery

http://utokyo-ent.org/

Our research is composed of both clinical and basic research. Clinical research is conducted by specialized clinics in the hospital,
which experience ear diseases and hearing disorders from neonates to adulthood, head and neck cancer, paranasal diseases,
olfactory and disorders, vertigo and balance disorders and voice and swallowing disorders. Basic and experimental research intomolecular biology, electrophysiology and morphology is conducted in our department's laboratories.
●

Clinical researchCochlear implantation in deaf children and their development of hearing, speech and language
Surgical correction of congenial microtia and atresia and postoperative radical ears to improve
hearing
Quality of life in patients with head and neck cancer to restore speech and swallowing function
Vestibular research on the oculomotor and balance system and myogenic potential
Vestibular rehabilitation by electric stimulation
Survey of eosinophilic sinusitis and refractory allergic rhinitis
Survey and surgical treatment for swallowing disorders and esophageal motility disorders
Clinical sequencing for recurrent / metastatic head and neck cancer
Development of fluorescent probes for cancer cell imaging
Basic and experimental research
Molecular biology of the inner ear
Molecular biology of pharyngeal cancer
Molecular biology of differentiation and development of inner ear and olfactory epithelium
Aging and regeneration of olfactory epithelium, pathogenesis of chronic sinusitis and allergic
rhinitis
Physiology of vocal cord vibration, Molecular biology of recurrent laryngeal papillomatosis
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Rehabilitation Medicine
Our research purpose is to elucidate the causalities between the pathology
of diseases and the limitation of activities and social participation of thepatients. The findings from that research would lead to the improvementof physical activities of people with disabilities.
Topics● Clinical research for congenital limb deficiency● Health promotion for people with chronic disabilities● Evaluation and intervention for dysphagia● Image analysis for bone metastasis

Anesthesiology

Equivalent stressswallowing videofluorography for cervical spondylosis

https://www.ut-anes.org/

We have seven research groups and their fields include respiratory,
cardiovascular, pain, nervous, and immune systems.Our ongoing andrecent major research subjects are:Respiratory system – A role of cytokine signaling in acute lung injury;
Transpulmonary pressure during mechanical ventilation; Exploring risk
factors of perioperative exacerbation of interstitial lung disease;● Immune system – Modification of immune system by anesthesia;
Apoptotic signal transduction induced by sepsis or ischemia-reperfusion
injury;● Pain – A role of lipid mediators in the formation of hyperalgesia; A role ofspinal microglial cells in the development of inflammation-mediatedneuropathic pain; Cognitive-behavioral therapy on chronic pain;
Clinical Practice and Research of Anesthesiology● Nervous system – Analysis of electroencephalography during generalanesthesia; Exploring relationship between postoperative delirium and bloodbrain barrier dysfunction;● Metabolism – Clinical significance of fatty acid metabolites in general anesthesia;● Cardiovascular system – Retrospective analyses on perioperative management of left ventricular assisting device
implantation or heart transplantation; Physiology and molecular biology of left/right heart failure of animal models;● Medical device – Invention and validation of new anesthetic procedures with emerging technologies;● Epidemiological survey and outcome study with large administrative database.
●42

Emergency and Critical Care Medicine

https://www.tokyodam.com/

Emergency and critical care medicine aims to develop diagnostics and therapeutics for acute and critical medical
diseases. Its scope covers not only clinical medicine but also basic medicine and social medicine.
Acuity of injury and illness related studies●●

Establishment of conception of "definitive acuity"
Acuity and severity scoring system

Methodology of task switching in the setting of multitask at ER
Improvement of outcome of emergency patients by mobile on-site
physicians team
● Performance indicators of medical control for paramedics● Performance indicators of regional emergency medical service system● Critical care related studies

Research Field
Field ofof Acute
Emergency
andResearch
Medicine	
Critical Care Medicine●●

Relationship between biomarkers and severity of critically illness
Non invasive monitoring technology to predict circulatory shock status

Versatile and durable WEB-based information sharing system for emergency
medical service system and disaster medical response.
● Mass casualty incident and natural disaster medical response related studies
●

●
●

Preh

●

ospit
Disa al care mster
med edicine
icine

●

Resuscita*on	
  and	
  ini*al	  treatment	

Mul%disciplinary	
  approach	
  and	  analysis	Prehospital	
  and	  disaster	  	
  medical	  response	

Inte
nsive
C
Trau are Med
mato
ic
logy ine●

Cri*cal	
  care	  of	
  serious	
  illness	  and	
  injury	Investigation of regional disaster medical risk-resource-ratio (static approach)
Dynamic simulation model of necessity of regional medical resource in MCI and large scale natural disaster

43

Health Sciences and Nursing

Mental Health / Psychiatric Nursing

https://mhpn.m.u-tokyo.ac.jp/

Our departments conduct research on mental health and psychosocial stress and provide education/ training of professionals in
related fields from global perspectives.
●

Mental Health
●
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Mental health epidemiology
Occupational mental healthTrauma-Informed Care
Perinatal Mental HealthInternet-based Cognitive Behavioral Therapy
Disaster and mental health
Global mental health

Psychiatric Nursing●●●●

Supporting people living with mental health problems
Wellness self-management in mental health
Recovery for people with mental illness
Peer support

Biostatistics / Epidemiology and Preventive Health Sciences

http://www.epistat.m.u-tokyo.ac.jp/

We are working on methodological researches of biostatistics andtheoretical epidemiology, as well as consulting and supporting the
conduct of epidemiologic/clinical studies. The followings are ourimportant missions: statistics education for undergraduate and graduate
students; the support of planning and analysis for clinical trials
conducted in the University of Tokyo Hospital Clinical Research Promotion
Center; and the support of resource development for academic
biostatisticians.
●

Methodology
●
●
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●

Design and analysis of clinical trials/epidemiologic studies
Statistical analysis of real-world data
Causal inference, missing data analysis and meta-analysis

Collaborative projects
●

●
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44

Research for the Construction of Trial Ready Cohort on preclinical andprodromal dementia (J-TRC)
Individual patient data based meta-analyses for gastric cancer
Japan Environmental and Children's Study (JECS)

What is a causal effect? Biostatistics provides the means tocausal inference from observed data.

Nursing Administration / Advanced Clinical Nursing

http://nurs-adm.umin.jp/

We aim to identify mechanisms and methods to maximize the potential ofpeople and organizations to bring happiness to all patients, nurses andother healthcare professionals, organizations, and society. With this aim, we
try to develop new models and techniques of nursing care that support
people's health, and to create better systems and environments asorganizations and societies surrounding nursing.
Visualization of nursing care using devices
Clarifying the mechanisms underlying the rationale for care
● Social and organizational systems for sustainability of nursing
organizations●●

http://www.fn.m.u-tokyo.ac.jp/en/

Family Nursing
Changes in society, such as the declining birthrate, super-aging population,
urbanization, globalization, and gender equality, have brought about changes infamily forms and functions, and family problems and needs have become morediverse and complex. Therefore, family nursing research focusing on not only
individual persons with a problem but also their family as one system is essential
to increase the happiness and well-being of the whole family. Our department
focuses on family nursing research to help families overcome the various
challenges and problems they face and to make the whole family happier.
Improvement of perinatal mental health and child abuse prevention with theperspective of attachment styles● Development of Pediatric QOL Inventory for children with chronic illness andtheir parents● Transitional care for children, adolescent and young adult with childhood-onset
chronic diseases and their families● Support for families suffering violence and prevention of the transmission ofviolence● Multidisciplinary collaboration for families and communities● Development of an inclusive educational program for preschool and elementary
school children●

Community Health Nursing

https://chiikikango.m.u-tokyo.ac.jp/en/

The goal of our department is to continuously maintain and improve thehealth and quality of life of people regardless of their life stages andhealth statuses, by taking advantage of the characteristics of a target
community or population and constructing the system. Also, we cover
the research on skills of public health nurses who are the provider ofcommunity health care.
Construction of community health care system
Community health care for mothers and children, adults, older people,
and mental disorders● Community health nursing for disaster prevention and recovery● Skills of public health nurses●●

Assessing community’s characteristics for Community Diagnoses

Health education program for older people

45

Gerontological Home Care and Long-term Care Nursing/ Palliative Care Nursing
https://longtermcare.m.u-tokyo.ac.jp/

Our research activities are related to nursing care of adults/older
people with chronic conditions and their families.
We hope to construct a culturally-sensitive knowledge base forthe discipline of nursing.
① Balancing care staff wellbeing with quality assurance andimprovement of care in long-term care facilities and at home
Development of quality indicators for quality of care,● Development of a system for managing quality of care
● Case study② Building new knowledge of carethrough case studies③ New developments in nursing practicein a community- based society● Development of dementia-friendly
community using Gamification andVR●① Feedback report to facility usingdeveloped quality indicators for quality of care
② Online seminar of case studies

Midwifery and Women's Health

http://midwifery.m.u-tokyo.ac.jp/en/

The physical and psychological changes that occur during the perinatal period have a critical influence on women’s lifelong
health. Additionally, this influence extends to their children, families, and communities. Our department specially focuseson the health of mothers and children in the perinatal period and mainly performs research in the following areas:●

Creating evidence of health guidance during pregnancy●●

Healthy lifestyle: adequate maternal nutrition, weight management, exercise, physical activity,
sleep, and mental health

Development of a support system for reliable childbirth
●
●
●
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●
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●

Midwifery care for positive childbirth experiences
Addressing ‘Fear of childbirth’ and psychosocial factors among pregnant Japanese womenDevelopment of assessment methods of birth canal using transperineal ultrasonography
Development of the strategy for safe delivery in El Salvador
Evaluating care in-hospital midwife-led system and in-hospital midwifery clinic
Evaluation of learning efficacy of Virtual Reality on midwifery education: Collaborative research
between Japan, Australia, and New Zealand
Development and effectiveness of an online Japanese version of mindfulness-based childbirthand parenting program●

Development of a support system for postpartum body management●

Development of a support system for women’s health

●

●
●

●

Pelvic floor disorders among postpartum women

Support for health of working mothers and women
Support for breastfeeding mothers and babies

Creative evidence of health guidance for neonatal skin care●●

Development of an effective skin care intervention to prevent neonatal skin problems
Changes in neonatal skin barrier function and skin resident microflora by skin care

Gerontological Nursing / Wound Care Management

Drawing / Shoichi Sakamoto

http://www.rounenkango.m.u-tokyo.ac.jp/
index-e.html

With the aim of creating a society in which people feel that growing old is not a bad thing, the mission of our department is to (1)realize a care situation that does not force people to suffer, and (2) establish new nursing care technologies for medical patients
who are unable to express their suffering. Our research is based on the method of reverse translational research, in which themechanisms of clinical issues to be addressed by nursing science are investigatedthrough basic research, devices are developed to intervene in the identified targets(e.g., engineering), and the technologies and systems are evaluated in clinicalpractice to identify new issues. Based on these methods, we are implementing"nursing science and engineering" to develop and disseminate non-invasive, nonconstraining, real-time nursing technologies and devices.
Elucidation of the pathogenesis of hard-to-heal wounds and development ofmanagement technologies● Search for biomarkers that reflect skin conditions● Development of technology for early detection and prevention of extravascularleakage of intravenous fluids● Development of a device to promote healing of diabetic foot ulcers by a novel
mechanism to accelerate glucose metabolism● Development of a new pad to prevent incontinence-associated dermatitis● Development of advanced nursing skills transfer method using VR/AR/MR●

Products developed through reverse translational research46

Health Sciences and Nursing
Health Sociology See Health and Social Behavior(p52)
Health Education See Health and Social Behavior(p52)
Biomedical Ethics See Biomedical Ethics(p52)47

International Health

Global Health Policy

http://www.ghp.m.u-tokyo.ac.jp

Our mission is to improve the health and well-being of people and the planet through excellence in research, education,
training, and service. We generate new knowledge and innovations through research, enhance the capacity for global andplanetary health research, and support advocacy and implementation of health policies, especially in resource-limited
settings.
The priority areas of research are:
Air Pollution and Health
Climate Change and Human Health● Domestic Health Policy Reform● Extreme Events and Severe Environmental Exposures● Global Burden of Disease● Global Health Governance● Health Emergencies and Disaster Risk Management● Infectious Diseases in Changing Environment● Nutrition Science and Policy● Urban Health●●Community and Global Health
Global health is about achieving equity, social justice, and narrowing
unacceptable health gaps globally. To achieve this, all countries and people
should share their experience and wisdom to help people have control
over and improve their health and well-being. In other words, ending
global health itself is the goal of global health. Our department conducts
research in the following areas:
Health, nutrition, and development
Health, human rights, and human security● Infectious disease control (malaria, TB, HIV, NTDs, etc.)● Health promotion (in particular, health literacy)● Disaster and health● Human resources for health● Maternal, newborn, and child health● Implementation research● Positive deviance approach●●48

http://www.ich.m.u-tokyo.ac.jp/en/index.html

Human Genetics

http://www.humgenet.m.u-tokyo.ac.jp/index.en.html

Human Genetics is a field focusing on the diversity of the human genome, and can include studies into the molecularmechanisms of genetics, evolutionary history of homo sapiens, cancer genome, as well as susceptibility genes forcommon and rare diseases. The findings of such genetic studies have proven useful in many applications, from supporting
clinical diagnosis of diseases to drug development and therapy. Recent advancements in genomic analyses have allowed
us to obtain enormous amounts of genetic and transcriptomic data. Such data will continue to grow in size and utilization
in society, reflecting the increasing importance of the field of human genetics.

Developmental Medical Sciences

http://www.development.m.u-tokyo.ac.jp

Our department conducts studies on emerging and re-emerging viral infectious diseases of public health importance with aims
on to develop better control measures for these diseases. Viruses of public health importance includes Dengue, Zika, Japanese
encephalitis, SARS-CoV-2 and other pathogenic viruses. We aim to contribute to the overall community health by using a
combination of traditional and cutting-edge approaches across different specialty fields including virology, immunity, genetics,
clinical and field work.
Epidemiology, virological andmolecular studies of thepathogenesis of tropical andemerging viruses● Development of diagnostic tools
and bioinformatics methods toanalyze viruses of regional concern● Host immune response during
infection and elucidation ofpathogenesis during viral infection● Vaccine and therapeutics
development● Infectious disease in developmental biology and public health
Each research topic is designed to answer global challenges in controlling infectious diseases, through innovative approaches
and novel solutions and, in collaboration with our national and global counterparts.
●

Human Ecology

http://www.humeco.m.u-tokyo.ac.jp/en/

The field of human ecology encompasses a wide range of perspectives inan effort to understand human health in relation to adaptation to physicaland social environments. To this end, we use methodologies developed inhuman biology, nutritional sciences, anthropology, demography,
environmental health, and urban ecology. The major topics of our studies
include:Health impact of exposure to heavy metals, air pollution, unhealthy urban
structures, and ecosystem degradation;● The roles of gut microbiota in nutritional adaptation and the evolution ofhuman populations;● Mitigation of the health impacts of aging and depopulation at community/
national scales;● Biological and behavioral explanations of low fertility and fecundity during
the post-demographic transition period;● Interaction among subsistence, nutrition and health; and● Medical anthropology; ecological anthropology.
●

A community in Laos.

Rice terraces in West Java, Indonesia.

49

Biomedical Chemistry
Our major research interests include virulence mechanisms and metabolism
of protozoa, particularly Plasmodium spp. causing malaria and Entamoeba
histolytica causing amebic dysentery. We mainly focus on vesiculartrafficking, phagocytosis, autophagy, proteases, amino acid metabolisms,
RNA maturation, translation, drug development, and organellogenesis. Our
research approaches are very robust, and include biochemistry, molecularand cell biology, live imaging, multi-omics including metabolomics, andreverse genetics. Our present research themes include:
Molecular elucidation of pathogenesis of parasites
Biochemical and biological analyses of metabolism and organelles unique toparasites● Analysis of vesicular traffic, protein secretion, and phagocytosis/trogocytosis
in parasites● Genome wide analysis and comparison of parasite strains● Drug discovery and development against protozoan infections such as
malaria and amebiasis● Elucidation of divergence of RNA maturation and translation●●

50

Entamoeba histolytica eating human cells

School of Public Health

Clinical Epidemiology and Health Economics
Through the cooperation with the specialists of
epidemiology, statistics, clinical medicine, and economics,
we implement multidisciplinary studies on clinicalepidemiology, health economics, health technology
assessment and health policy using large healthcare
databases.
Clinical epidemiological studies using the Diagnosis
Procedure Combination database● Health economics and policy studies using thegovernmental statistics● Application of statistical methods for observational
studies● Integration of multiple databases●

Health Communication

https://www.umin.ac.jp/hc/index.html

We are developing empirical research on a wide range of communication
types at various levels in the field of health communication studies. These
range from interpersonal communication to media communication. Amonglaboratories in Japan focused on health communication studies, we have themost publications, research funds, faculty members, and graduate students.
Our research areas include:● Communication for supporting health-care consumers’ behavioral change● Decision-making by health-care consumers● Media information’s impact on health-care consumers● Online health information● Health literacy● Patient-provider communication

51

Mental Healthhttps://mhpn.m.u-tokyo.ac.jp/

The Department of Mental Health has engaged in education andresearch on a wide range of topics related to mental health, such associal determinants of stress and mental health. The Departmentp r ov i d e s c l a s s e s o f M e n t a l H e a l t h I ( e p i d e m i o l o g y a n dcountermeasures in mental health) and Mental Health II (TraumaInformed Care, Perinatal Mental Health, and Occupational Mental
Health).
Community-based mental health epidemiology
Occupational mental health● Internet-based Cognitive Behavioral Therapy● Perinatal Mental Health● Trauma-Informed Care
● Disaster and mental health● Global mental health●●

Health and Social Behavior
The unit follows the legend of former departments of health sociology,
health education, and social gerontology, and extends its academic
endeavor to empirically reveal complex mechanisms between social
structure/relationship and individual health/behavior. Throughinterdisciplinary and global communication with social science andhealth science, the unit aims at exploring research and education onsocial determinants of health, such as;Trans-generational health impact of socioeconomic status
Health impact of retirement and social participation among the elderly● Policy intervention design to alleviate social exclusion● The impact of healthcare systems for health equity● Social experiences of chronically ills and their health●●

Biomedical Ethics

http://www.ethps.m.u-tokyo.ac.jp/

The Department of Biomedical Ethics conducts both theoreticaland empirical studies in the fields of biomedical ethics,
research ethics and clinical ethics. Research topics include
ethical theories, public health ethics, informed consent, ethics
committees and organ transplantation. The Bioethics
Collaborative Research Organization was recently set up as an
adjunct to the Department of Biomedical Ethics. (https://bicro.
u-tokyo.ac.jp/)
Study of the functions and responsibilities of ethics committees inJapan● Study of the methods for the formation of social consensus related
to advanced medical technology● Comparative study of clinical ethics in the Asian region● Study of ethical aspects in neuroscience researches● Ethics in Public Health Emergencies● Psychosocial and ethical aspects of living related organtransplantation●

52

Researchers from all over the world frequently visit our centerfor joint researches and active discussions.

Health Policy

https://plaza.umin.ac.jp/publichealth/

The Department of Health Policy addressess o c i e t y ' s c u rr e n t h e a l t h a n d h e a l t h c a r e
problems. Our research identifies problems
through discussions with various stakeholders,
including policymakers, clinicians, patients, andcommunity residents. We emphasize bothresearch and practice.
The Department is concurrently operated with
the Department of Public Health.
Quality of health care
Disease control activities● Healthcare resource allocation● Injury prevention●●

International comparison of age-standardized cause-specific mortality rateby occupational class among men aged 35-64

Healthcare Informatics

http://www.m.u-tokyo.ac.jp/medinfo/

The Department of Biomedical Informatics aims to reform medical
systems and make social contribution by applying information
technology to medical and clinical field including hospital
information management. The department develops innovative
methods that are applicable to medical information systems in theboundary area of healthcare and information science, establishes
infrastructures for information environment, and applies knowledge
and technique acquired through these efforts to medical andhealthcare field.
The main keywords of the target domain are medical and clinicalinformation systems, next-generation electronic health record
systems, virtual health care environment, mobile health, and AI
including natural language processing as well as machine learning.
Development and application of clinical ontology
Automatic Mapping from Clinical Case Dara to
Knowledge of Disease Transition
Research for sharing healthcare data among medical institutions
and hospitals, and the application for clinical epidemiology● Extraction of medical knowledge from electronic medical record database using natural language processing● Development of knowledge-driven real time alerting system in clinical practice● R&D of medical artificial Intelligence and mobile healthcare system●●

Clinical Information Engineering

http://webpark1893.sakura.ne.jp/wp/researches/

Clinical Information Engineering focuses on computer applications
that address biomedical data (collection, analysis, representation). It
is a combination of information science, computer science, andclinical science designed to assist in the management and processingof data, information and knowledge to support the practice anddelivery of clinical care and public health.
ClinVR: Clinical Interactive 3D Computer Graphics & Virtual reality
PHI: Social information engineering for Public Health (Public Health
Informatics: GIS for Health Science etc.)● Elucidation of the medical effects of virtual experiences on thehuman body (VR medicine)●●53Forensic Medicine and Medical Law

http://ut-forensic.jp

We conduct autopsies, and various examinations including histology,
biochemistry, radiology, toxicology, and genetics as usual practices. We also
perform the following research with other institutes and departments
including Education and Research Center of Legal Medicine, Chiba University,and Department of Forensic Medicine, School of Medicine, International
University of Health and Welfare.
Application of imaging modalities such as CT and MRI for death investigation
Age and stature estimation and sex
determination using CT● Biomechanical properties of human tissue● Diagnosis of drowning● Research for infectivity of SARS-CoV-2 indecedents● Analysis and pathophysiology of illegal drugs
including new psychoactive substances● Application of relatively new DNA testing
method for practice of forensic medicine●●

Global Environmental Health
The Department of Global Environmental Health (GEH) aims
to study the relationships between the environment andhuman health and to produce well-educated professionals
with the ability to undertake epidemiological research. Our
research interest includes climate change and variability, air
pollution, and human health across multiple countries inenvironmental epidemiology. We address the scientificquestions about how the environmental stressors areassociated with health outcomes and potential socioeconomic determinants that modify the exposure-response
associations. The GEH provides two courses, 1) Environmental
Health and 2) Methods for Environmental Health Research.

Forensic autopsy room

CT roomhttps://sites.google.com/m.u-tokyo.ac.jp/envhealth

Geographical distribution of the MCC network
for the suicide-temperature association study

Health risk assessment of climate change and air pollution
Seasonality of suicide and the short-term associations between suicideand atmospheric environmental factors based on a large-scale
database of the multi-city multi-country (MCC) network● Development of a statistical prediction model for malaria early warning
systems in Southern Africa●●

School of Public Health
Biostatistics See Biostatistics / Epidemiology and Preventive Health Sciences(p44)
Health Sociology and Health Education See Health and Social Behavior(p52)
54

Center for
Disease Biology and Integrative Medicine

http://www.bm2.m.u-tokyo.ac.jp/index-e.html

Structual Physiology
We have been exploring two-photon excitation microscopy, which
utilizes an infrared femtosecond-pulsed laser as a light source, tovisualize and stimulate intact tissues at the cellular and molecularlevels. We focus on the functions and disorders of the brain.
●

The dynamics of synapses in the cerebral cortex and striatum,in relation to memory, cognitive processes and mental disorders

Fine structure and function of a central neuron studied
with two-photon excitation imaging and uncaging

Biomedical Equipment and Biomaterials
The aim of our research is to contribute to the development ofinnovative biomedical equipment and biomaterials for clinicalapplications. Our approach is multidisciplinary, integrating
principles from basic and clinical medicine withbioengineering, in particular mechanical engineering. Research
efforts are focused on exploring the potential of advanced
robotic technologies and VR simulation to aid surgicalprocedures and scientific experiments, with a particularemphasis on automation capabilities.

http://www.cdbim.m.u-tokyo.ac.jp/
Robots for biomedical applications (Biomedical Equipment)
Surgery

Scientific experiments

Automation
Segmentation

Tele-operation

For neurosurgery

Trajectory
optimization

For eye surgery

Constraints
for automation
For microscopic task

55

Clinical Biotechnology

https://grn.tokyo/med/en/

Our mission is to establish therapeutic strategies for skeletal
disorders based on understanding of mechanisms underlying
skeletal development, skeletal metabolism and pathology ofskeletal disorders. We explore data-driven studies by omics
analysis focusing on epigenome. By integrating withbioengineering, we apply the study for modeling of tissue
development, establishment of platform for drug discovery andachievement of regenerative medicine.
Identifying dynamics of epigenome and gene regulation inskeletal development and repair by utilizing omics analysis andbioinformatics● Development of screening tools for identifying mechanisms
underlying skeletal development and pathology of skeletal
tissues.
● Modeling human skeletal development of disorders by utilizing
pluripotent stem cells● Development of implant devices for tissue regeneration by
integrating high-performance biomaterials and signaling
molecules stimulating tissue repairing processes.
●

Microenvironmental and Metabolic Health Sciences
Lipids serve as the largest energy source, cell membrane components,
and bioactive mediators. Lipids are major environmental substances
supplied as nutrients and spatiotemporally regulate a variety of
biological responses in response to given microenvironmental cues
within tissues. Our research focuses on the regulation of biologicalnetworks driven by lipids and their metabolites. By taking advantagesof an array of gene-manipulated mice for lipid-metabolizing enzymes
and receptors, we aim to clarify novel lipid-orchestrated mechanisms
underlying various diseases such as metabolic and immune
disorders. Knowledges obtained from these approaches will betranslated to humans toward discovery of new biomarkers or
druggable targets.

https://lmmhs.m.u-tokyo.ac.jp
Lipid Biology for Health Sciences

Research of Quality of Lipids (QOL) for Quality of Life (QOL)
LipidsPhospholipase A2 (PLA2) family

PLA2 family(~30 genes）
PLA2‐related lipase family(>70 genes）

Knockout mice

Lipidomics
Diseases

Understanding of spatiotemporal lipid flows in health and diseases

Discovery of novel lipid pathways
that are linked to biological processes

Animal Resources / Research Resources and Support - Animal Research
Our laboratory focuses on understanding the molecular mechanisms
which underlie the brain function and cancer metastasis. We also try
to establish animal models for human psychiatric disorders bygenerating KO mice and marmosets. We also manage the animal
facilities, provide reproductive technology service, advice on animal
experiments, and give lectures on laboratory animals so that animal
experiments are carried out in accordance with animal welfare.
Molecular analysis of brain function and cancer using geneticallymodified mice
● Development of new model animals for psychiatric disorders● Development of gene targeting animals using CRISPR/Cas system●

A mutant mouse lacking metabotropic glutamate receptor
subtype-1 (mGluR1)

56

Molecular Radiology / Reserch Resources and Suport-Radiation Biology
We are investigating the molecular mechanisms of DNA double-strand
break repair as the scientific basis of radiation therapy andchemotherapy in medical oncology. We also promote the basic researchthat contributes to the development of a novel therapeutic strategy byexamining a link of the DNA metabolic network including DNA
replication and cell cycle control with chromosome instability.

http://www.cdbim.m.u-tokyo.ac.jp/
english/index.html

Molecular mechanisms of homologous recombinational repair
Mechanisms of the choice between homologous recombination andnon-homologous end-joining● Molecular mechanisms of DNA rereplication● Mechanisms of the genesis of aneuploidy● Functional analysis of meiotic recombination genes●●

Centrosome fragmentation which may lead to aneuploidy

Biomedical Informatics

http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

The department conducts researches on the development of medical
artificial intelligence systems and their application to clinical practice(i.e., clinical decision support, knowledge discovery from big data, andso on), utilizing the combined approach of medical knowledge
representation, logical reasoning, and machine learning techniques. We
actively collaborates with the department of Medical informatics,
Graduate School of medicine, and the department of Planning,
Information and Management in the University of Tokyo Hopistal, to
conduct those researches using clinical information. Our activities also
include the practical management of information infrastructure to
support medical researches.
Development and application of clinical ontology
Development of clinical decision support systems using logicalreasoning and machine learning● Clinical text analysis and knowledge extraction using natural language
processing● Development of next-generation EHR system●●

Computer System for Biomedical Research

57

The International Research Center
for Medical Education

Department of Medical Education Studies
The mission of the Department of Medical Education Studies
includes the promotion of medical education not only in the Facultyof Medicine, the University of Tokyo but also in the whole country.
This department works on activities of educational practice or
improvement and promotes research related to the medical
education field. In the university, this department offers educational
activities such as clinical clerkship, PBL (problem-based learning),
clinical skill practical training, and the conduction of OSCE (objective
structured clinical examination). Simulation-based training is alsooffered at the Clinical Simulation Center, The University of Tokyo
Hospital.
Clinical Simulation Center

International Cooperation for Medical Education
This is a department that disseminates basic theory on medical/
health professions education domestically and internationally,
thereby improving health care in a broader sense. In particular, ourstrengths include learner assessment, program evaluation, clinicalreasoning/ clinical decision making, general practice/ family
medicine/ primary care, health communication, and patient-healthprovider relationship. In addition, we are involved in human resource
development in the field of health care and its international
cooperation, and support projects related to medical/ healthprofessions education in Japan and overseas.

58

Global Nursing Research Center

Division of Care Innovation

http://gnrc.m.u-tokyo.ac.jp/en/

With a falling birthrate and a super-aging society, Japan is in need of a paradigm shift that will move it away from a ‘medicalcare that cures’ toward a ‘Medical and nursing care that supports.’ In such a situation, nursing science that plays a key role of‘care’ is expected to foster different field interdisciplinary research / educational environment aiming to nurture young
nursing researchers who can lead care innovation. In our department, with bio-scientist/engineering researchers andcompanies, we aim to develop and care products that reduce inconvenience ofdaily life due to the health impairment of each person, accept young researchersand establish an innovative nursing research fields based on transdisciplinary
integration.
Data collection and development of AI prediction models for halth conditions basedon sensor data
● Development of AI-based care recommendation application that visualizes diseasestates and presents appropriate care methods● Application of AI/AR to support self-learning of nursing skills● Development of educational program for visualization techniques using
ultrasonography● Development of AI-based image evaluation support tools● Creation of animal models of skin diseases and wounds and elucidation of theirmechanisms● Development of non-invasive physical condition assessment methods using skin /wound blotting techniques●

Division of Care Systems
Our goal is to foster research activities that promote person-centered care, tailored to meet the unique needs ofindividuals and their families, and to develop a community that thrives through nursing practices rooted in culture andsociety. We aim to create a care system that engages the community and involves collaboration with various specialized
fields, such as information technology, policy science, educational psychology, and philosophy.
●

Person Centered Care Development
●

●
●

●

Development of care practices with a focus on the well-being ofboth care providers and care receivers
Innovative research with evaluation by care receivers as an outcome
Creation of a new continuous quality improvement system

Community Symbiosis Development
●
●

●

●

Construction of “Dementia Friendly Community”
Development and implementation of educational programs toenhance care competency of community individuals
Our goal is to create a supportive environment where community
members can rely on one
another and cultivate strong
relationships within thehealthcare community
Establishment of support
systems for health andsocial care professionals

59Center for Diversity in Medical Education and ResearchCenter for Diversity in Medical Education and Research
Patients and people with disabilities are the best designers of health care services. If people with disabilities are able to beproviders of medical care based on their own experiences, it will lead to the realization of patient-centered medical care. The
Center for Diversity in Medical Education and Research aims to improve the quality of medical services through thedissemination and implementation of team medicine that is inclusive of medical staff with disabilities by integrating
medicine, social welfare and disability studies.
●

Education
●

●

●
●

●

●

Introduction of Diversity Education in the Graduate School of Medicine and the Faculty of
Medicine
Development of a barrier-free system for faculty of the Graduate School of Medicine, theFaculty of Medicine, and the University of Tokyo Hospital
Development of a training system for medical staff with disabilities
Improvement of the educational environment for students with disabilities enrolled in the
Graduate School of Medicine and the Faculty of Medicine
Training of peer support workers

Research
●

●
●

●

60

Identification of barriers on the social side by analyzing and creating a database of hospitalduties, research activities, and other tasks
Reform of technical standards and examination of appropriate reasonable accommodations
Examination of the quality of medical care provided by medical personnel with disabilities orwith the same attributes
Examining the impact of diversity education for medical students and residents on reducing
stigma and improving the quality of medical careInstitution

Medical Libraryhttps://www.lib.m.u-tokyo.ac.jp

The University of Tokyo Medical Library was opened in 1961 as a model of theJapanese modern medical library. The view makes it a perfect place toconcentrate on study.
The library has adopted an open stack system so that users can have directaccess to almost all the materials.
Holdings (as of March 31 2022) :Books(number of volumes) : 270,572 (Japanese 113,706 Foreign 156,866)
Periodicals(number of titles) :3,547 (Japanese 1,706 Foreign 1,841)● Visitors (2021): 4,560*● Borrowed Books (2021): 12,584●*To deal with COVID-19, our library had restricted use in 2021.

Office of International Academic Affairs

http://koryu.m.u-tokyo.ac.jp/

The Office of International Academic Affairs (OIAA) is under the direct authorityof the Dean of the Graduate School of Medicine. The Committee on
International Academic Affairs defines the most important responsibilities of
the OIAA as (1) promoting and facilitating international educational exchange,(2) fostering international exchange among researchers, (3) helping young
researchers excel as scientists and educators, and (4) offering classes on
medical English to, and developing educational materials for, medical students.

61

Medical Scientist Training Program

http://www.ut-mdres.umin.jp/

Medical Scientist Training Program was launched in 2008, aiming
medical students have the opportunity to experience basic research intheir early years and learn the attitude of a researcher. Students taking
this program will attend extracurricular activities such as journal clubs
and English courses of Medical Research Communications as well as
their own research in labs, retreat and the defense of research honors
theses. Students are also expected to build up a network among
medical students who intend to be a researcher through the programsupport, such as the short term stay at labs abroad, participations to thesymposium, and the excursion with other universities.

Museum of Health and Medicine

http://mhm.m.u-tokyo.ac.jp/

Museum of Health and Medicine was planned as part of commemorative projects to celebrate the anniversary of thefounding of the Graduate School of Medicine and the University of Tokyo Hospital. Our Museum was opened on Jan. 20th,
2011 and is located in the South Clinical Research Bldg.
The permanent exhibition is a display medical archives and instruments from the early era, such as Ishihara’s Color Blind
Test Charts and the gastrocamera developed at the University. Special exhibitions is planned to promote understanding
among the regarding advances in medical science and health.

Office for Human Research Studies
Office for Human Research Studies (OHRS) aims to protect the rights, health,and dignity of research participants. Based on this principle, OHRS supports
researchers at the Graduate School of Medicine, the Faculty of Medicine andthe University Hospital to perform their studies in an ethical manner. Our
primary task is the management of the Ethics Committee secretariats.
Additionally, we provide ethics education to researchers through research
ethics seminars, ethics consultations through support of overall medical
writing, and then externally dispatch information on research ethics.

62

Life Sciences Core FacilityLife Sciences Core Facility provides researchers at the graduate school of
medicine and the faculty of medicine access and technical assistance tospecialized instruments including mass spectrometers, cell sorters, flow
cytometers and a state-of-the-art fluorescent microscope.

The Office for Clinical Practice and Medical Education
The Office for Clinical Practice and Medical Education was established in April
2015 to promote medical education, especially clinical training for the 5th- and6th-year medical students.
We facilitate the clinical clerkship program and establish liaison between
students, faculty and other medical institutions, as well as enhance theclerkship curriculum and evaluation methods.
For individual students, we provide extended support by collaborating with thestudent support office and the educational office of the faculty of medicine.
With the International Research Center for Medical Education and other medical
faculties, we also conduct research on medical education, particularly on therelationship between high-stakes examination and important educational
outcomes, and the relationship between the scores and daily life.

Advisory Office for Conflict of Interest
Advisory Office for Conflict of Interest implements for medical research(including clinical research) conducted in Graduate School of Medicine, Facultyof Medicine and The University of Tokyo Hospital, as well as for full-time andpart-time researchers involved in research. It serves as the secretariat for the
conflict of interest committee. It also engages in activities to enhance the risk
management and legal management systems both inside and outside themedical school, such as providing consultation on risk management andcompliance, responding to inquiries from researchers and related departments
inside and outside the medical school, and engaging in activities to improve
literacy through training, etc.
Its main duties are as follows:● Conflict of interest management for medical research involving humansubjects (including clinical research)● Conflict of interest management for medical research for which the MHLW
and AMED serve as funding allocation agencies● Conflict of interest management as a Tokyo University staff member● Other activities related to risk management and legal affairs, such as
responding to consultations from within the university regarding industryacademia collaboration, contracts, university-originated startups, researchdata utilization, and personnel management.

63

Ikenohata Gate

Clinical Research
Bldg.(East)

Clinical Research
Bldg.(North)

Molecular &Life Innovation
Bldg.

ClinicalResearch Bldg.A

Clinical Research
Bldg.(West)

ClinicalResearch Ward
Central Bldg. Inpatient(North)Bldg. B
Inpatient
Bldg. A

Central Bldg.
(East)

Central Bldg.
(South)Central Clinical
Service Bldg.1
Central Clinical
Service Bldg.2

Administration Bldg.

Tetsu-mon
Gate

Med.4

Outpatient Clinic
Bldg.

South ClinicalResearch Bldg.

Tatsuokamon Gate

MedicalLibrary

International
ResearchCenterMed.2

Med.5
Bioscience
Reseach Bldg.
Med. Experimental
Research Bldg.

Med.3

Kasuga Gate

Annex of
Med.3

Med.1

Main Gate

AkamonGate

Hongo-sanchome Stn.
on Subway Line
: Marunouchi Line: Oh-edo Line

Masaomi Nangaku, Dean, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo
Address:7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
http://www.m.u-tokyo.ac.jp
Issued on May, 2023