SAFETY DATA SHEETThis safety data sheet was created pursuant to the requirements of:Regulation (EC) No. 1907/2006 and Regulation (EC) No. 1272/2008
Revision Date 31-May-2023

Revision Number 3

EGHS / English_____________________________________________________________________________________________The supplier identified below generated this SDS using the UL SDS template. UL did not test, certify, or approve the substance described in this SDS, andall information in this SDS was provided by the supplier or was reproduced from publically available regulatory data sources. UL makes no representations
or warranties regarding the completeness or accuracy of the information in this SDS and disclaims all liability in connection with the use of this informationor the substance described in this SDS. The layout, appearance and format of this SDS is © 2014 UL LLC. All rights reserved.

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Section 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE
COMPANY/UNDERTAKING
1.1. Product identifier
Product Code(s)CAS11195, CAS11859, CAS11860, CAS12024, CAS12025, CAS12026,
CAS12205, CAS12206, CAS12207

Product Name

Edit-R Cas9 Nuclease Protein (NLS)

Chemical name
Reach Number

A registration number is not required for this substance.

1.2. Relevant identified uses of the substance or mixture and uses advised against
Recommended Use

For research use only.

Uses advised against

No information available.

1.3. Details of the supplier of the safety data sheetSupplier Name

Dharmacon Inc.
Revvity, Inc.

Supplier Address

2650 Crescent Drive Suite 100
Lafayette, CO 80026

Supplier Phone Number

Tel: 303-604-9499
Fax: 303-604-9680

Supplier Emailtechnical@horizondiscovery.com

For further information, please contact.
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1.4. Emergency telephone number
Emergency telephone

Chemtrec International

1-703-741-5970

Emergency telephone §45 - (EC)1272/2008
Europe112

SECTION 2: Hazards identification
2.1. Classification of the substance or mixture
Classification of substance according to Regulation (EC) No 1272/2008 (CLP)
Not a hazardous substance or mixture.

2.2. Label elements
Label elements according to Regulation (EC) No 1272/2008 (CLP)
Not a hazardous substance or mixture.

2.3. Other hazards
No information available

SECTION 3: Composition/information on ingredients
3.1 Substances
Chemical nameEC No

CAS-NoWeight-%Glycerol-200-289-5<50%Classification according
to Regulation (EC) No.
1272/2008 [CLP]No data available

REACH Reg.
No.
No dataavailable

Full text of H- and EUH-phrases: see section 16
This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC)No. 1907/2006 (REACH), Article 59)
Chemical name
CAS-NoSVHC candidates
Glycerol200-289-5-SECTION 4: First aid measures
4.1. Description of first aid measures
Inhalation

Remove to fresh air.

Skin contact

Wash skin with soap and water. In the case of skin irritation or allergic reactions
see a physician.

Eye contact

Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower andupper eyelids. Consult a physician.

Ingestion

Clean mouth with water and drink afterwards plenty of water.

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4.2. Most important symptoms and effects, both acute and delayed
Symptoms

No information available.

4.3. Indication of any immediate medical attention and special treatment needed
Note to physicians

Treat symptomatically.

Section 5: FIRE FIGHTING MEASURES
5.1. Extinguishing media
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and thesurrounding environment.

Unsuitable extinguishing media No information available.
5.2. Special hazards arising from the substance or mixture
Specific hazards arising from the chemical
Thermal decomposition can lead to release of irritating and toxic gases and vapors.
5.3. Advice for firefighters
Special protective equipment for fire-fighters
Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. Use personal protection
equipment.

SECTION 6: Accidental release measures
6.1. Personal precautions, protective equipment and emergency procedures
Personal precautions

Ensure adequate ventilation.

For emergency responders

Use personal protection recommended in Section 8.

6.2. Environmental precautions
Environmental precautions

Should not be released into the environment. See Section 12 for additional
Ecological Information.

6.3. Methods and material for containment and cleaning up
Methods for containment

Prevent further leakage or spillage if safe to do so.

Methods for cleaning up

Take up mechanically, placing in appropriate containers for disposal.

6.4. Reference to other sections
Reference to other sections

See section 8 for more information. See section 13 for more information.

SECTION 7: Handling and storage
7.1. Precautions for safe handling_____________________________________________________________________________________________

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Advice on safe handling

Ensure adequate ventilation.

General Hygiene Considerations Handle in accordance with good industrial hygiene and safety practice.
7.2. Conditions for safe storage, including any incompatibilities
Storage Conditions

Keep container tightly. Store at -20°C.

7.3. Specific end use(s)Risk Management Methods(RMM)

The information required is contained in this Material Safety Data Sheet.

Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1. Control parameters
Exposure Limits

This product, as supplied, does not contain any hazardous materials withoccupational exposure limits established by the region specific regulatory bodies

Derived No Effect Level (DNEL) No information available
Predicted No Effect Concentration (PNEC) No information available
8.2. Exposure controls
Personal protective equipment
Eye/face protection

Tight sealing safety goggles.

Skin and body protection

Wear suitable protective clothing.

Environmental exposurecontrols

No information available.

SECTION 9: Physical and chemical properties
9.1. Information on basic physical and chemical properties
Physical state
ColourOdour

LiquidColorless
MildProperty
Melting / freezing point
Boiling point / boiling range
Flammability
Lower and Upper Exposure Limit
Flash Point
Auto-ignition Temperature
Flammability Limit in Air
Decomposition TemperaturepH
Kinematic viscosity
Solubility

ValuesData not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
6.4
Data not relevant for safe use
Data not relevant for safe use

Remarks Method
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known_____________________________________________________________________________________________

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Partition coefficient: n-octanol/water Data not relevant for safe use
Vapour pressure
Data not relevant for safe use
Density / Relative Density
Data not relevant for safe use
Relative vapour density
Data not relevant for safe use
Decomposition temperature
Data not relevant for safe use
Particle characteristics
Data not relevant for safe use

None known
None known
None known
None known
None known
None known

9.2. Other information
Softening Point
Molecular Weight
VOC Content (%)
Liquid Density
Bulk Density
Particle Size
Particle Size Distribution

Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use

SECTION 10: Stability and reactivity
10.1. Reactivity
No data available.
10.2. Chemical stability
Stable under normal conditions.
Explosion Data
Sensitivity to Mechanical Impact
Sensitivity to Static Discharge

None.
None.

10.3. Possibility of hazardous reactions
Possibility of Hazardous
ReactionsNone under normal processing.

10.4. Conditions to avoid
None known.
10.5. Incompatible materials
No information available.
10.6. Hazardous decomposition products
None under normal use conditions.

SECTION 11: Toxicological information
11.1. Information on toxicological effects
Information on likely routes of exposure
Product Information_____________________________________________________________________________________________

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Inhalation

Specific test data for the substance or mixture is not available.

Eye contact

Specific test data for the substance or mixture is not available.

Skin contactSpecific test data for the substance or mixture is not available.

Ingestion

Specific test data for the substance or mixture is not available.

Information on toxicological effects
Symptoms

No information available.

Numerical measures of toxicity
Acute Toxicity

Unknown acute toxicity

Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation

No information available.

Serious eye damage/eye
irritation

No information available.

Respiratory or skin sensitization No information available.
Germ cell mutagenicity

No information available.

Carcinogenicity

No information available.

Reproductive Toxicity

No information available.

STOT - single exposure

No information available.

STOT - repeated exposure

No information available.

Aspiration hazard

No information available.

SECTION 12: Ecological information
12.1. Toxicity
Ecotoxicity

No information available.

12.2. Persistence and degradability_____________________________________________________________________________________________

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Persistence and Degradability

No information available.

12.3. Bioaccumulative potential
Bioaccumulation

No information available.

12.4. Mobility in soil
Mobility in soil

No information available.

12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment

No information available.

12.6. Other adverse effects
Other adverse effects

No information available.

SECTION 13: Disposal considerations
13.1. Waste treatment methods
Waste from residues/unusedproducts

Dispose of in accordance with local regulations. Dispose of waste in accordancewith environmental legislation.

Contaminated packaging

No information available.

SECTION 14: Transport information
IMDG
14.1 UN Number
14.2 Proper Shipping Name
14.3 Hazard Class
14.4 Packing group
14.5 Marine Pollutant
14.6 Special Provisions
14.7 Transport in bulk
according to Annex II ofMARPOL and the IBC CodeRID
14.1 UN-No.
14.2 Proper Shipping Name
14.3 Hazard Class
14.4 Packing Group14.5 Environmental hazard
14.6 Special Provisions

Not regulatedNot regulated
Not regulated
Not regulated
Not applicableNone
Not applicableNot regulated
Not regulated
Not regulated
Not regulated
Not applicable
None

ADR
14.1 UN-No.
Not regulated
14.2 Proper Shipping Name
Not regulated
14.3 Hazard Class
Not regulated_____________________________________________________________________________________________

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14.4 Packing Group14.5 Environmental hazard
14.6 Special Provisions

Not regulated
Not applicable
None

IATA
14.1 UN Number
14.2 Proper Shipping Name
14.3 Hazard Class
14.4 Packing group
14.5 Environmental hazard
14.6 Special Provisions

Not regulated
Not regulated
Not regulated
Not regulated
Not applicable
None

SECTION 15: Regulatory information
15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related tochemical agents at work .
Authorizations and/or restrictions on use:
This product does not contain substances subject to authorization (Regulation (EC) No. 1907/2006 (REACH), Annex
XIV). This product does not contain substances subject to restriction (Regulation (EC) No. 1907/2006 (REACH),Annex XVII).
Persistent Organic Pollutants
Not applicable.

Ozone-depleting substances (ODS) regulation (EC) 1005/2009
Not applicable.
International InventoriesTSCADSL/NDSL
EINECS/ELINCS
ENCS
IECSC
KECL
PICCS
AICS

Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.

LegendTSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified ChemicalSubstances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances_____________________________________________________________________________________________

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AICS - Australian Inventory of Chemical Substances
15.2. Chemical safety assessment
No information available.

SECTION 16: Other information
Key or legend to abbreviations and acronyms used in the safety data sheet
Legend
SVHC: Substances of Very High Concern for Authorization:
Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTIONTWATWA (time-weighted average)
STELCeiling
Maximum limit value-STEL (Short Term Exposure Limit)
Skin designation

Key literature references and sources for data
www.ChemADVISOR.com/
Revision Date31-May-2023

This safety data sheet complies with the requirements of: Regulation (EC) No. 1907/2006.
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information andbelief at the date of its publication. The information given is designed only as a guidance for safe handling,use, processing, storage, transportation, disposal and release and is not to be considered a warranty orquality specification. The information relates only to the specific material designated and may not be valid forsuch material used in combination with any other materials or in any process, unless specified in the text.
End of Safety Data Sheet

Data for Regulatory Rules_____________________________________________________________________________________________

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