★★★＜第１３回知的財産翻訳検定試験【第６回英文和訳】＞ ★★★
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Gene therapy has also been attempted using viral constructs as expression
vectors for genes expressing tumor antigens. For example, a recombinant vaccinia
virus construct encoding modified forms of human papilloma virus (HPV) E6 and E7
protein sequences has been used for immunization of patients with cervical cancer.
Vaccination with this construct yielded questionable clinical responses(Borysiewickz, 1996). See also, Sanda, 1999 wherein a recombinant vaccinia-PSA(prostate-specific antigen) construct was used as a vaccine in prostate cancer
patients.
Another approach has been dendritic cell-mediated therapy, e.g., wherein
dendritic cells were pulsed with oligopeptide fragments of prostate-specificmembrane antigens (PSMA). The dendritic cells (with or without the priming PSMAantigens) were then administered to patients with metastatic prostate cancer.
Major clinical responses were obtained in only a low percentage of patients(Murphy, 1999; see also, Tjoa, 2000)＊＊＊END＊＊＊[問２]＊＊＊START＊＊＊から＊＊＊END＊＊＊までを和訳してください。

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In additional embodiments, the nootropic agent as used herein includes aneurogenesis modulating agent or combination, as defined herein, that elicits anobservable neurogenic response by producing, generating, stabilizing, orincreasing the retention of an intermediate agent which, when contacted with thenootropic agent, results in the neurogenic response. As used herein, "increasing
the retention of" or variants of that phrase or the term "retention" refer todecreasing the degradation of, or increasing the stability of, an intermediate
agent.
In some cases, the nootropic agent, optionally in combination with one ormore other neurogenic agents, neurogenic sensitizing agent or anti-astrogenicagent, results in improved efficacy, fewer side effects, lower effective dosages,
less frequent dosing, and/or other desirable effects relative to use of theneurogenesis modulating agents individually (such as at higher doses), due, e.g.,
to synergistic activities and/or the targeting of molecules and/or activities
that are differentially expressed in particular tissues and/or cell-types.
A neuromodulating combination may be used to inhibit a neural cell'sproliferation, division, or progress through the cell cycle. Alternatively, aneuromodulating combination may be used to stimulate survival and/ordifferentiation in a neural cell. As an additional alternative, a neuromodulating
combination may be used to inhibit, reduce, or prevent astrocyte activation
and/or astrogenesis or astrocyte differentiation.
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Example 2: In vivo Effects of a Single Dose of lambda'-(2-fluoro-4-(methylsulfonyl)
phenyl)-5-methyl-6-(l-(5-methylpyrazin-2-yl)piperidin-4-yloxy)pyrimidin-4-amineon Oral Glucose Tolerance Test (oGTT) in Male SD Rats (PK/PD study) at 0.3 and3 mg/kg.
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The oral glucose tolerance test (oGTT) measures the ability of an animal
to metabolize a bolus of exogenous glucose. A decrease in glucose AUC excursion
from baseline indicates better glucose control. Male SD rats (6 - 7 weeks ofage) were housed one rat per cage in a temperature-controlled room with 12-hour
light/dark cycle. They were allowed ad libitum access to water and food. Rats
1

were fasted overnight before the study. These rats were first dosed with vehicle(0.5%HPMC) or Compound 1 at 0.3, or 3 mg/kg doses via oral gavage at 8:30 am.
One hour after compound dosing, rats were administered glucose (2 g/kg, using
50% glucose solution) by oral gavage and the tail blood samples were collected
to measure blood glucose and plasma insulin at 0, 30, 60, and 120 min. A
separate group of rats were dosed in similar fashion and blood samples collected
at 1, 2, 4, 6, 8, and 24 h after dosing for PK analysis.
Compound 1 significantly reduced the blood glucose AUC during OGTT at boththe 0.3 and 3 mg/kg doses. The compound levels in the plasma showed a dose-relatedincrease.
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次の英文クレームを翻訳してください。

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What is claimed is:
1. An isolated microorganism deposited as ATCC accession number, PTA-10253, or aherbicide resistant strain derived therefrom.
9. An inoculant for application to plants, comprising an effective quantity ofthe microorganism of claim 1, and an agricultural carrier.
13. The inoculant according to claim 9, wherein:
the effective quantity comprises an amount of at least 5 x 10 colony
forming units per gram of the formulation; andthe inoculant further comprises:
an encapsulating material that forms microbeads encapsulating the herbicide
resistant rhizobia strain when dried.
14. The inoculant formulation of claim 13, further comprising:a particulate machine lubricant including at least one of talc andgraphite.
15. A method for enhancing the growth of a plant, the method comprising the stepof placing in the vicinity of the plant an effective quantity of a herbicide
resistant microorganism deposited as ATCC accession number, PTA- 10253 or astrain derived therefrom, the strain able to enhance the growth of plants.
16. The method of claim 15, wherein the placing step further comprises the stepof:
administering the herbicide resistant microorganism by a method selectedfrom the group consisting of application to the seeds of the plant, application
to the plant, application to the locus of the plant root, and application by
in-furrow spray.
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