PRODUCT DATASHEETPLGA MICROPARTICLEPRODUCTION STATION
Standard Pack, P/N: 1DPPL01
Automation Pack, P/N: O-SEPLGAAP-PCK

The Fluigent PLGA particle station is a robust and a high-quality system for producing monodispersed PLGA particles with flexibility to rapidly change particle
sizes and production rates without interrupting production. Its performance resultsfrom the combination of Fluigent’s high precision LineUPTM microfluidic pumps andthe RayDrop, a breakthrough technology for high-quality particle production device.

PRODUCT DATASHEETDESCRIPTION
When PLGA is used as active pharmaceutical ingredient (API) carrier, the size ofthe particle is critical as it affects drug release characteristics. It is then essential to produce highly monodispersed particle for drug release reproducibility.
The most common production process of PLGA particles is solvent based andcan involve hazardous solutions. Ethyl acetate has been referenced as a less hazardous solvent than other conventional ones (dichloromethane for instance).
Specifically designed for ethyl acetate solvent-based

particleforma- tion,

it shows highly reproducible results in term of particle size distribu- tion (CV<2%). This station is particularly suitable forresearchers who want totest

different API encapsulation conditions with highly reproducible results.

STATION OPTIONSStandard pack Automation pack
Flow EZTM: High precision pump
FLOW UNIT : High precision flow sensors
RayDrop device
A-i-O control Software
P-CAP reservoirs
Tubing, connector and fitting kits
2-SWITCHTM valves
Automated device priming
MAT Software
Highspeed digital microscope

Full packPRODUCT DATASHEETDETAILED CONTENTS
Standard Pack
P/N: 1DPPL01
Content
2 * Flow EZTM (2000 mbar)
1 * Link
2 * FLOW UNIT (M and L)
3 * P-CAP (2 * 15 mL and 1 * 50 mL)
1 * RayDrop
1 * Support RayDrop
A-i-O SoftwareStandard connector and tubing kit
Flow EZTM supply kit

Figure 1: PLGA microparticle production
station, standard pack content

Set-up overview

Figure 2: PLGA microparticle production station, standard pack set-up

PRODUCT DATASHEET
Automation Pack
P/N: O-SE-PLGAAP-PCKContent
2 * Flow EZTM (2000 mbar)
1 * Link
2 * FLOW UNIT (M and L)
3 * P-CAP (2 * 15 mL and 1 * 50 mL)
2 * 2-SWITCHTM
1 * Switchboard
1 * RayDrop
1 * Support RayDrop
A-i-O Software
MAT Software
Automation connector and tubing kit
Flow EZTM supply kit

Figure 3: PLGA microparticle production
station, automation pack content

Set-up overview

Figure 4: PLGA microparticle production station, automation pack set-up

PRODUCT DATASHEETSETTING-UP THE STATION
Please refer to the Good Practice Guide.

TECHNICAL SPECIFICATIONSParticle production
Resomer® RG 753 S, Poly(D,L-lactide-co-glycolide) ester
Dispersed phaseterminated, Lactide: Glycolide 75:25, dissolved in ethyl
acetate, mol wt 66,000-107,000
PLGA concentration used 2%, 5% and 10%
Continuous phase

Water + PVA

Droplet size range

60 µm to 120 µm

Particle size range*

20 µm to 50 µm

Production rate*

Up to 60 mg/h

Production frequency*

Up to 1000 Hz

Monodispersity

2%

Flow control
Pumps**

Fluigent Flow EZTM (2000 mbar)

Flow sensors**

Fluigent FLOW UNIT (M and L)

Automated valves**

Fluigent 2-SWITCHTM

Imaging
Microscope

Fluigent Digital high-speed microscope

SoftwareLive control

Fluigent A-i-O

Automated control

Fluigent MAT

Imaging

Pixelink Capture Software*Depending on PLGA concentration (see PLGA microparticle synthesis application note)**For detailed specification: download LineUPTM User Manual, ESSTM User Manual.

PRODUCT DATASHEETCONTACT⽇本代理店: 株式会社ASICON
Local distributor in Japan: ASICON Tokyo Ltd.
asicon-tokyo@asicon-tokyo.com
www.asicon-tokyo.com