News Release
4 March 2024
EPS Innovative Medicine (Japan) Co., Ltd.

Biotube Co., Ltd. became the subsidiary ofEPS Innovative Medicine (Japan) Co., Ltd.

A group company of EPS Creative Health Technology Group Ltd.（HKEX：3860，Executive
Director/CEO Tatsuji Shimada, MBA, hereinafter “EPS CHT”), EPS Innovative Medicine (Japan)
Co., Ltd. (Representative Director: Tomohiro Nakatani) announced that on January 29, 2024, it
acquired shares of Biotube Co., Ltd. (Representative Director: Yasuhide Nakayama, PhD,
hereinafter “Biotube”), which is developing medical devices specialized in iBTA technology*1,making Biotube a consolidated subsidiary. EPS CHT intends to create synergies by making Biotube
a member of the group company and also to commercialize medical devices.

EPS CHT is exploring the creation of new businesses in the area of drug discovery, including
regenerative medicine, with the aim of providing innovative medical care.

Biotube has developed a device that enables the subcutaneous formation of Biotube tubular tissue
from the patient’s own tissue and is conducting a physician-initiated clinical trial for lower extremity
artery bypass surgery for patients with CLI*2. The company has also developed a device that enables
the subcutaneous formation of tissue bodies in which the patient’s own stem cells and is conducting
a physician-initiated clinical trial for wound treatment in patients with diabetic foot ulcers*3.

EPS

CHT and Biotube will work together as a group to aggressively pursue the earlycommercialization of iBTA technology*1 for the implementation of new regenerative medicine insociety.

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【Overview of Biotube】
Name:

Biotube Co., Ltd.

Address:

2F Ginza Otake Bijidensu, 1-22-11 Ginza, Chuo-ku, Tokyo

Representative:

Yasuhide Nakayama, PhD

Establish:

2017

Business:

Development and sales of medical equipment【About EPS CHT】
In April 2021, EPS Holdings Inc. (Representative Director Hao Yan), a Japanese-based Contract
Research Organization (CRO), Site Management Organization (SMO) and Contract Sales
Organization (CSO) for pharmaceutical and medical device development in Asia, acquired 75%
shares in Speed Apparel Holding Ltd., and renamed the company EPS Creative Health Technology
Group Ltd. Currently, we are working on a new healthcare business in China and Asia in cooperation
with EPS Holdings, Inc.

＜Overview of EPS CHT＞（URL：https://epshk.hk/en/）Name:

EPS Creative Health Technology Group Ltd.（HKEX：3860）

Address:

Room 3301, West Tower, Shun Tak Centre, Sheung Wan, Hong Kong

Representative:

Executive Director/CEO Tatsuji Shimada, MBA

Establish:

November 19, 2015

Business:

Apparel ODM Business
Drug Discovery Support Business・Japan-China Specialized CRO Business・Licensing & Financing Support Business /Japan-China Medical Exchange Business・Japan Pharmaceutical Development Business
HCP (Healthcare Products) Business
Drug Discovery and Development

Capital:HK$ 52,656,000

Parent Company: EPS Holdings, Inc. （URL：https://www.eps-holdings.co.jp/en/）2 / 3

*1: iBTA (in Body Tissue Architecture) technology is a technology to create tissue fortransplantation by utilizing the phenomenon of encapsulation that occurs around a foreign body
implanted in the living body.

*2: Critical limb ischemia (CLI) is a condition in which chronic ischemic rest pain and leg ulcers
and gangrene are observed due to arterial occlusive disease. If blood flow to the lower limb is not
improved by revascularization, it may result in amputation of the lower limb or death.

*3: Diabetic foot ulcers are one of the most common complications in patients with diabetes mellitus.
Diabetic patients have narrowed blood vessels in their feet, which reduces blood flow, and they may
also suffer from neuropathy such as decreased sensation in the feet, so even if a wound develops due
to infection, symptoms such as pain are unlikely to appear and may not be noticed until the condition
becomes serious. It is difficult to heal and is also progressive, progressing from an ulcer to gangrene,
which may lead to amputation of the lower limb or death.

【About EPS Innovative Medicine Co., Ltd.】We are a core company of EPS Creative Health Technology Group Co., Ltd. in the pharmaceutical
discovery business. Our goal is to develop the seeds introduced from academia and Biotech venturecompanies and the seeds found in our research department based on the knowledge and know-how
cultivated by the EPS Group over many years, expanding the value of seeds and aims at promoting
to Japan and China markets, or to license out to the partner enterprises.

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