2019 以前の Publication list
(1)

Yokoyama, Y.; Arai, M. A.*; Hara, Y.; Ishibashi, M.* "Nonactic acid derivatives(2)

isolated from Streptomyces werraensis IFM12104 in a screening program for
BMI1 promoter inhibitory activity" Nat. Prod. Commun. 2019, 14 (7)1934578X19866583, DOI:10.1177/1934578X19866583
Yokoyama, Y.; Arai, M. A.*; Hara, Y.; Ishibashi, M.* "Identification of BMI1

(3)

promoter inhibitors from Streptomyces sp. IFM-11958" Bioorg. Med. Chem. 2019,27, 2998-3003. DOI:10.1016/j.bmc.2019.05.002
Arai, M. A.*; Ochi, F.; Makita, Y.; Chiba, T.; Higashi, K.; Suganami, A.; Tamura,Y.; Toida, T.; Iwama, A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.* "GLI1
inhibitors isolated by target protein oriented natural products isolation(TPO-NAPI) with hedgehog inhibition" ACS Chem. Biol. 2018, 13, 2551-2559．

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DOI: 10.1021/acschembio.8b00492 (*selected as a cover article)
Hara, Y.; Arai, M. A.; Toume, K.; Masu, H.; Sato, T.; Komatsu, K.; Yaguchi, T.;
Ishibashi, M. "Coculture of a pathogenic actinomycete and animal cells to produce
nocarjamide, a cyclic nonapeptide with Wnt signal-activating effect" Org.
Lett. 2018, 20, 5831-5834. DOI:10.1021/acs.acs.orglett.8b02522
Hara, S.; Hara, Y.; Arai, M. A.; Kusuya, Y.; Takahashi, H.; Yaguchi, T.; Ishibashi,
M. "Isolation of nabscessin C from Nocardia abscessus IFM 10029T and a study
on biosynthetic pathway for nabscessins" Chem. Pharm. Bull. 2018, 66,
976-982. DOI:10.1248/cpb.c18-00430
Arai, M. A.*; Masuda, A.; Suganami, A.; Tamura, Y.; Ishibashi, M.* "Synthesis
and evaluation of fuligocandin B derivatives with TRAIL resistance overcoming
activity" Chem. Pharm. Bull. 2018, 66, 810-817. (*selected as a cover article)(Highlighted
paper
selectedby
Editor-in-Chief)
DOI:10.1248/cpb.c18-00308

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Arai, M. A.*; Akamine, R.; Hayashi, N.; Koyano, T.; Kowithayakorn, T.;
Ishibashi, M.* " The Notch Inhibitors Isolated from Nerium indicum " J. Nat.
Prod. 2018, 81, 1235-1240. DOI:10.1021/acs.jnatprod.7b01031
Arai, M. A.*; Akamine, R.; Tsuchiya, A.; Yoneyama, T.; Koyano, T.;
Kowithayakorn, T.; Ishibashi, M.* "The Notch inhibitor cowanin accelerates
nicastrin degradation" Sci. Rep. 2018, 8, 5376. DOI:10.1038/s41598-018-23698-4
Sampei, M.; Arai, M. A.*; Ishibashi, M.* " Total syntheses of schizandriside,saracoside and (±)-isolariciresinol with antioxidantMed. 2018, 72, 651-654. DOI:10.1007/s11418-018-1198-6

activities" J.

Nat.

(10) Seephonkai, P.; Ishikawa, R.; Arai, M. A.; Kowithayakorn, T.; Koyano, T.;

Ishibashi, M. "New flavanol dimers from the bark of Celtis tetranda and their
TRAIL resistance-overcoming activity" Nat. Prod. Commun. 2018, 13, 427-430.
(11) Hara, Y.; Arai, M. A.; Sakai, K.; Ishikawa, N.; Gonoi, T.; Yaguchi, T.; Ishibashi,
M. "Dehydropropylpantothenamide isolatedbyaco-culture
Tof Nocardia tenerifensis IFM 10554 in the presence of animal cells" J. Nat.
Med. 2018, 72, 280-289. DOI:10.1007/s11418-017-1161-y(12) Liu, X.; Arai, M. A.; Toume, K.; Ishibashi, M. "Isolation of resistomycin from aterrestrial actinomycete with TRAIL resistance-overcoming activity" Nat. Prod.
Commun. 2018, 13, 65-66.
(13) Yoneyama, T.; Arai, M. A.*; Akamine, R.; Koryudzu, K.; Tsuchiya, A.; Sadhu, S.
K.; Ahmed, F.; Itoh, M.; Okamoto, R.; Ishibashi, M.* "Notch inhibitorsfrom Calotropis gigantea that induce neuronal differentiation of neural stem
cells" J. Nat. Prod. 2017, 80, 2453-2461. DOI:10.1021/acs.jnatprod.7b00282(14) Karmakara, U. K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
"Boesenberols I-K, new isopimarane diterpenes from Boesenbergia pandurata with
TRAIL-resistance overcoming activity" Tetrahedron Lett. 2017, 58,
3838-3841. DOI:10.1016/j.tetlet.2017.08.055(15) Arai, M. A.*; Yamaguchi, Y.; Ishibashi, M.* "Total Synthesis of Agalloside,
Isolated from Aquilaria agallocha, by the 5-O-Glycosylation of Flavan" Org.
Biomol. Chem. 2017, 15, 5025-5032. DOI:10.1039/C7OB01004D(16) Arai, M. A.*; Utsumi, T.; Yanase, N.; Fujimatsu, T.; Ishibashi, M.* "Efficientsynthesis of heterocyclic flavonoids with hedgehog signal inhibitory
activity" Chem. Pharm. Bull. 2017, 65, 784-795. (Highlighted paper selectedby Editor-in-Chief)
DOI:10.1248/cpb.c17-00305(17) Arai, M. A.*; Tanaka, M.; Tanouchi, K.; Ishikawa, N.; Ahmed, F.; Sadhu, S. K.;

Ishibashi, M.* "Hes1 binding compounds isolated by Target Protein Oriented
Natural Products Isolation (TPO-NAPI)" J. Nat. Prod. 2017, 80, 538-543.
DOI:10.1021/acs.jnatprod.6b01072(18) Yoneyama, T.; Arai, M. A.*; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.*"Isolation and evaluation of hedgehog inhibitors from Christmas grass (Themeda
arguens)" Heterocycles 2017, 95, 210-222. DOI:10.3987/COM-16-S(S)4(19) Kaneta, Y.; Arai, M. A.; Ishikawa, N.; Toume, K.; Koyano, T.; Kowithayakorn,

T.; Chiba, T.; Iwama, A.; Ishibashi, M. "Identification of BMI1 promoter
inhibitors from Beaumontia murtonii and Eugenia operculata" J. Nat. Prod. 2017,80, 1853-1859. DOI:10.1021/acs.jnatprod.7b00138

(20) Arai, M. A.*; Ishikawa, N.; Tanaka, M.; Uemura, K.; Sugimitsu, N.; Suganami,A.; Tamura, Y.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.* "Hes1 inhibitor
isolated by target protein oriented natural products isolation (TPO-NAPI) ofdifferentiation activators of neural stem cells" Chem. Sci. 2016, 7, 1514-1520.
DOI:10.1039/c5sc03540f(21) Arai, M. A.*; Taguchi, S.; Komatsuzaki, K.; Uchiyama, K.; Masuda, A.; Sampei,

M.; Satoh, M.; Kado, S.; Ishibashi, M.* "Valosin-containing Protein is a Target of5'-l Fuligocandin B and Enhances TRAIL Resistance in Cancer Cells"
ChemistryOPEN, 2016, 5, 574-579. DOI: 10.1002/open.201600081(22) Arai, M. A.*; Kofuji, Y.; Tanaka, Y.; Yanase, N.; Yamaku, K.; Fuentes, R. G.;

Karmakar, U. K.; Ishibashi, M.* "Synthesis of rocaglamide derivatives andevaluation of their Wnt signal inhibitory activities" Org. Biomol. Chem. 2016, 14,3061-3068. DOI:10.1039/c5ob02537k(23) Karmakar, U. K.; Ishikawa, N.; Arai, M. A.; Ahmed, F.; Koyano, T.;

Kowithayakorn, T.; Ishibashi, M. "Boesenberols, pimarane diterpenes with TRAIL
resistance-overcoming activity from Boesenbergia pandurata" J. Nat. Prod. 2016,
79, 2075-2082. DOI:10.1021/acs.jnatprod.6b00424(24) Shono, T.; Ishikawa, N.; Toume, K.; Arai, M. A.; Masu, H.; Koyano, T.;

Kowithayakorn, T.; Ishibashi, M. "Cerasoidine, a bis-aporphine alkaloid isolated
from Polyalthia cerasoides during screening for Wnt signal inhibitors" J. Nat.
Prod. 2016, 79, 2083-2088. DOI:10.1021/acs.jnatprod.6b00409(25) Fujita, K.; Sugiyama, R.; Nishimura, S.; Ishikawa, N.; Arai, M. A.; Ishibashi, M.;

Kakeya, H. "Stereochemical assignment and biological evaluation of BE-14106
unveils the importance of one acetate unit for the antifungal activity of polyene
macrolactams"
J.
Nat.
Prod.
2016,
79,
1877-1880.
DOI:10.1021/acs.jnatprod.6b00250(26) Ahmed, F.; Toume, K.; Ishikawa, N.; Arai, M. A.; Sadhu, S. K.; Ishibashi, M.

"Constituents from Entada scandens with TRAIL-resistance overcoming activity"
Nat. Prod. Commun. 2016, 11, 993-995.
(27) Karmakar, U. K.; Toume, K.; Ishikawa, N.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.;

Ishibashi, M. "Bioassay-guided isolation of compounds with TRAIL-resistanceovercoming activity from Datura stramonium" Nat. Prod. Commun. 2016, 11,185-187.
(28) Arai, M. A. *; Uemura, K.; Hamahiga, N.; Ishikawa, N.; Koyano, T.;

Kowithayakorn, T.; Kaddar, T.; Carreau, M.; Ishibashi, M. * "Naturally occurring
FANCF-Hes1 complex inhibitors from Wrightia religiosa" Med. Chem. Commun.

2015, 6, 455-460. (招 待 論 文 ; Themed issue, New Talent: Asia-Pacific).
DOI:10.1039/C4MD00495G(29) Arai, M. A. *; Koryudzu, K.; Ishibashi, M. * "Inubosins A, B, and C are new

acridine alkaloids isolated from Streptomyces sp. IFM 11440 that show Ngn2
promoter activity" J. Nat. Prod. 2015, 78, 311-314. DOI:10.1021/np5006218(30) Arai, M. A.*; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Koyano, T.; Kowithayakorn,

T.; Ishibashi, M.* "Hedgehog inhibitors from Artocarpus communis and Hyptis
suaveolens"Bioorg.
Med.
Chem.
2015,
23,
4150-4154.
DOI:10.1016/j.bmc.2015.06.058(31) Arai, M. A.*; Akamine, R.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.*"Hedgehog/GLI- mediated transcriptional activity inhibitors from Crinum
asiaticum" J. Nat. Med. 2015, 69, 538-542. DOI:10.1007/s11418-015-0922-8(32) Yoneyama, T.; Arai, M. A.*; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.* "Hedgehog

inhibitors from Withania somnifera" Bioorg. Med. Chem. Lett. 2015, 25,3541-3544. DOI:10.1016/j.bmcl.2015.06.081(33) Fuentes, R. G.; Arai, M. A.*; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.* "Phenolic

compounds from the bark of Oroxylum indicum identified as Ngn2 promoter
activators" J. Nat. Med. 2015, 78, 864-872. DOI:10.1007/s11418-015-0919-3(34) Ohishi, K.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.

"Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits
Wnt signaling pathway by decreasing β-catenin mRNA expression" Bioorg. Med.
Chem. Lett. 2015, 25, 3937-3940. DOI:10.1016/j.bmcl.2015.07.036(35) Karmakar, U. K.; Ishikawa, N.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.;

Ishibashi, M. "Sesquiterpenes with TRAIL-resistance overcoming activity from
Xanthium strumarium" Bioorg. Med. Chem. 2015, 23, 4746-4754.
DOI:10.1016/j.bmc.2015.05.044(36) Shono, T.; Ishikawa, N.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.;

Ishibashi, M. "Boehmenan, a lignan, isolated from Hibiscus ficulneus showed Wnt
signal inhibitory activity" Bioorg. Med. Chem. Lett. 2015, 25, 2735-2738.
DOI:10.1016/j.bmcl.2015.05.037(37) Ohishi, K.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Mizoguchi,

T.; Itoh, M.; Ishibashi, M. "9-Hydorxycanthin-6-one, a β-carboline alkaloid from
Eurycoma longifolia, is the first Wnt signal inhibitor through activation of GSK3β
without depending on CK1α" J. Nat. Prod. 2015, 78, 1139-1146.
DOI:10.1021/acs.jnatprod.5b00153(38) Fuentes, R. G.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.

"Scopadulciol, isolated from Scoparia dulcis, induces β-catenin degradation andovercomes TRAIL resistance in AGS human gastric adenocarcinoma cells" J. Nat.
Prod. 2015, 78, 864-872. DOI:10.1021/acs.jnatprod.5b00153(39) Fuentes, R. G.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.

"Limonoids with Wnt signal inhibitory activity isolated from the fruits of
Azadirachta
excelsa"
Phytochem.
Lett.
2015,
11,
280-285.
DOI:10.1007/s11418-015-0919-3(40) Toume, K.; Habu, T.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.

"Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus
communis with the ability to overcome TRAIL resistance" J. Nat. Prod. 2015, 78,
103-110. DOI:10.1021/acs.jnatprod.5b00061(41) Tahmina, H.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.

"Isolation of alkamides with death receptor-enhancing activities from Piperchaba" Heterocycles 2015, 90, 1317-1322. DOI:10.3987/COM-14-S(K)68(42) Arai, M. A.*; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.* "Physalin H

from Solanum nigrum as Hh signaling inhibitor blocks GLI1-DNA complex
formation" Beil. J. Org. Chem. 2014, 10, 134-140. (招待論文; Themed issue,“Natural products in synthesis and biosynthesis”)(43) Park, H.-Y.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.

"Calotropin: a cardenolide from Calotropis gigantea that inhibits Wnt signaling byincreasing casein kinase 1α in colon cancer cells" ChemBioChem 2014, 15,872-878.
(44) Toume, K.; Tsukahara, K.; Ito, H.; Arai, M. A.; Ishibashi, M. "Chromomycins A2

and A3 from marine actinomycete with TRAIL resistance-overcoming activity and
Wnt signal inhibitory activity" Mar. Drugs 2014, 12, 3466-3476．
(45) Ohishi, K.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Mizoguchi, T.; Itoh,M.; Ishibashi, M. "Ricinine: a pyridone alkaloid from Ricinus communis that
activates the Wnt signaling pathway through casein kinase 1α" Bioorg. Med. Chem.
2014, 22, 4597-4601.
(46) Fuentes, R. G.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi,

M. "Constitutents from the rhizomes of Curcuma comosa and their Wnt signal
inhibitory activity" Heterocycles 2014, 88, 1501-1509.
(47) Park, H.-Y.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.

"β-sitosterol and flavonoids isolated from Bauhinia malabarica found in ascreening program for Wnt signal inhibitory activity" J. Nat. Med. 2014, 68,
242-245.

(48) Arai, T.*; Yamamoto, Y.; Awata, A.; Kamiya, K.; Ishibashi, M.; Arai, M. A.*"Catalytic Asymmetric Synthesis of Mixed 3,3’-Bisindoles and Their Evaluationas Wnt Signaling Inhibitors" Angew. Chem. Int. Ed. 2013, 52, 2486-2490.
(49) Arai, M. A.*; Fujimatsu, T.; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.*"Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the
GLI1–DNA complex" Mol. BioSyst. 2013, 9, 1012-1018.（招待論文；Themed
issue “Chemical Biology in Asia”）(50) Arai, M. A.*; Koryudzu, K.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.*"Naturally Occurring Ngn2 Promoter Activators from Butea superba" Mol.
BioSyst. 2013, 9, 2489-2497.
(51) Minakawa, T.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi,

M. "Prenylflavonoids isolated from Artocarpus champeden with TRAIL-resistanceovercoming activity" Phytochemistry 2013, 96, 299-304.
(52) Toume, K.; Kamiya, K.; Arai, M. A.; Mori, N.; Sadhu, S. K.; Ahmed, F.; andIshibashi, M. "Xylogranin B, a potent Wnt signal inhibitory limonoid from
Xylocarpus granatum" Organic. Lett. 2013, 15, 6106-6109.
(53) Tamai, Y.; Toume, K.; Arai, M. A.; Ishibashi, M. "Griseoviridin and cyclichydroxamates found in a screening program for Wnt signal inhibitor" Heterocycles
2012, 86, 1517-1524.
(54) Minakawa, T.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.

"Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in ascreening program for compounds to overcome TRAIL-resistance" J. Nat. Prod.
2012, 75, 1431-1435.
(55) Toume, K.; Nakazawa, T.; Tahmina, H.; Ohtsuki, T.; Arai, M. A.; Koyano, T.;

Kowithayakorn, T.; Ishibashi, M. "Cycloartane triterpenes and ingol diterpenes
isolated from Euphorbia neriifolia in a screening program for death-receptor
expression-enhancing activity" Planta medica 2012, 78, 1370-1377.
(56) Abdelfattah, M. S.; Toume, K.; Arai, M. A.; Masu, H.; Ishibashi, M."Katorazone,
a novel yellow pigment with 2-azaquinone-phenylhydrazone structure produced by
Streptomyces sp. IFM 11307" Tetrahedron Lett. 2012, 53, 3346-3348.
(57) Koryudzu, K.; Arai, M. A.; Ahmed, F.; Sadhu, S. K.; Ishibashi, M. "A new resin

glycoside from Ipomoea maxima" Nat. Prod. Commun. 2012, 7, 219-220.
(58) Yamaguchi, T.; Toume, K.; Arai, M. A.; Ahmed, F.; Sadhu, S. K.; Ishibashi, M.

"Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria
indica" Nat. Prod. Commun. 2012, 7, 475-477.
(59) Tamai, Y.; Toume, K.; Arai, M. A.; Hayashida, A.; Kato, H.; Shizuri, Y.;

Tsukamoto, S.; Ishibashi, M. "Nonactin and related compounds found in ascreening program for Wnt signal inhibitory activity" Heterocycles 2012, 84,1245-1250.
(60) Rifai, Y.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.

"Acoschimperoside P, 2’-acetate: a Hedgehog signaling inhibitory constituent
from Vallaris glabra" J. Nat. Med. 2011, 65, 629-632.
(61) Rifai, Y.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "New
Hedgehog/GLI signaling inhibitors from Excoecaria agallocha" Bioorg. Med.
Chem. Lett. 2011, 21, 718-722.
(62) Arai, M. A.*; Tateno, C.; Koyano, T.; Kowithayakorn, T.; Kawabe, S.; Ishibashi,
M.* "New Hedgehog/GLI-signaling inhibitors from Adenium obesum" Org.
Biomol. Chem. 2011, 9, 1133-1139.
(63) Toume, K.; Nakazawa, T.; Ohtsuki, T.; Arai, M. A.; Koyano, T.; Kowithayakorn,
T.; Ishibashi, M. "Cycloartane Triterpenes Isolated from Combretum
quadrangulare in a Screening Program for Death-Receptor Expression Enhancing
Activity" J. Nat. Prod. 2011, 74, 249-255. （(64) Ippongi, Y.; Ohtsuki, T.; Toume, K.; Arai, M. A.; Yamamoto, Y.; Ishibashi, M.

"Tubiferic acid, a new 9,10-secocycloartane triterpenoid acid isolated from the
myxomycete Tubulifera arachnoidea" Chem. Pharm. Bull. 2011, 59, 279-281.
(65) Munetsuna, E.; Nakabayashi, S.; Kawanami, R.; Yasuda, K.; Ohta, M.; Arai, M.

A.; Kittaka, A.; Chen, T. C.; Kamakura, M.; Ikushiro, S.; Sakaki, T. "Mechanismof the anti-proliferative action of 25-hydroxy-19-nor-vitamin D3 in human prostate
cells" J. Molecular Endocrinology 2011, 47, 209-218.
(66) Arai, M. A.*; Hanazawa, S.; Uchino, Y.; Li, X.; Ishibashi, M.* "Total synthesis
and evaluation of Wnt signal inhibition of melleumin A, B and their derivatives"
Org. Biomol. Chem. 2010, 8, 5285-5293.
(67) Arai, M. A.*; Seto, J.; Ahmed, F.; Uchiyama, K.; Ishibashi, M.* "Practical Total

Synthesis of Fuligocandins A, B"Synlett 2010, 16, 2498–2502.
(68) Rifai, Y.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Terpenoids

and flavonoid glycoside from Acacia pennata leaves as Hedgehog/GLI-mediatedtranscriptional inhibitors" J. Nat. Prod. 2010, 73, 995-997.
(69) Ahmed, F.; Toume, K.; Sadhu, S. K.; Ohtsuki, T.; Arai, M. A.; Ishibashi, M.
"Constituents of Amoora cucullata with TRAIL resistance overcoming activity"
Org. Biomol. Chem. 2010, 8, 3696-3703.

(70) Mori, N.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.

"2-Methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening
program for activity to inhibit Wnt signaling" J. Nat. Med. 2010, 65, 234-236.
(71) Shintani, A.; Toume, K.; Rifai, Y.; Arai, M. A.; Ishibashi, M. "A bisindole

alkaloid with hedgehog signal-inhibitory activity from the myxomycete Perichaena
chrysosperma" J. Nat. Prod. 2010, 73, 1711-1713.
(72) Minakawa, T.; Toume, K.; Ahmed, F.; Sadhu, S. K.; Ohtsuki, T.; Arai, M. A.;

Ishibashi, M. "Constituents of Pongamia pinnata Isolated in a Screening for
Activity to Overcome TRAIL-Resistance"Chem. Pharm. Bull. 2010, 58,
1549-1551.
(73) Brown, J. B.; Urata, T.; Tamura, T.; Arai, M. A.; Kawabata, T.; Akutsu, T.
"Compound Analysis via Graph Kernels Incorporating Chirality" J. Bioinfomatics
Comput. Biol. 2010, 8, 63-81.
(74) Kittaka, A.; Hara, H.; Yasuda, K.; Takano, M.; Arai, M. A.; Sawada, D.; Saito, H.;

Takenouchi, K.; Tai, T. C.; Sakaki, T., "Studies on the synthesis and metabolismof 14-epi-2α-(3-hydroxypropyl)-19-norvitamin D3 and its 2β-isomer" Heterocycles
2010, 82, 649-661.
(75) Arai, M. A.*; Masada, A.; Ohtsuka, T.; Kageyama, R.; Ishibashi, M. "The firstHes1 dimer inhibitors from natural products" Bioorg. Med. Chem. Lett. 2009, 19,5778-5781.
(76) Arai, M. A.*; Kobatake, E.; Koyano, T.; Kowithayakorn, T.; Kato, S.; Ishibashi,

M.* "A Method for the Rapid Discovery of Naturally Occurring Products byProteins Immobilized on Magnetic Beads and Reverse Affinity Chromatography"
Chem. Asian J. 2009, 4, 1802-1808.
(77) Ishibashi, M. and Arai, M. A. "Search for Bioactive Natural Products Targeting
Cancer-Related Signaling Pathways" J. Synth. Org. Chem., Jpn. 2009, 67,
1094-1104.
(78) Honzawa, S.; Takahashi, N.; Yamashita, A.; Sugiura, T.; Kurihara, M.; Arai, M.
A.; Kato, S.; Kittaka, A.,"Synthesis of a 1α-C-methyl analogue of
25-hydroxyvitamin D : Interaction with a mutant vitamin D receptor Arg274Leu"
Tetrahedron 2009, 65, 7135-7145.
3(79) Arai, M. A.*; Sato, M.; Sawada, K.; Hosoya, T.; Ishibashi, M.*, "Efficient

Synthesis of Chromone and Flavonoid Derivatives with Diverse Heterocyclic
Units" Chem. Asian J. 2008, 3, 2056-2064.
(80) Arai, M. A.*; Tateno, C.; Hosoya, T.; Koyano, T.; Kowithayakorn, T.; Ishibashi,
M.*,"Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphuscambodiana" Bioorg. Med. Chem., 2008, 16, 9420-9424.
(81) Hosoya, T.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Naturally
Occurring Small-molecule Inhibitors of Hedgehog/GLI-mediated Transcription"
ChemBioChem 2008, 9, 1082-1092. (most cited articles published in 2008 or
2009)(82) Hanazawa, S.; Arai, M. A.; Li, X.; Ishibashi, M. "Determination of absolutestereochemistry, total synthesis, and evaluation of peptides from the myxomycete
Physarum melleum" Bioorg. Med. Chem. Lett. 2008, 18, 95-98.
(83) Arai, M. A.; Uchino, Y.; Hanazawa, S.; Li, X.; Kimura, N.; Ishibashi, M.,"Synthesis and Evaluation of Isomers of Melleumin B from the Myxomycete
Physarum melleum; An Approach for Wnt Signal Inhibitor Trusted in Nature"
Heterocycles 2008, 76, 1425-1438.
(84) Honzawa, S.; Yamamoto, Y.; Yamashita, A.; Sugiura, T.; Kurihara, M.; Arai, M.
A.; Kato, S.; Kittaka, A. "The 2α-(3-hydroxypropyl) group as an active motif in
vitamin D3 analogues as agonists of the mutant vitamin D receptor (Arg274Leu) "Bioorg. Med. Chem. 2008, 16, 3002-3024.
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