High Performance Liquid Chromatography

PRODUCTSC A T A L O GHigh performance liquid chromatography is a necessary method in the analytical separation.
To perform high quality analysis, the new analytical method and devices including detector have been
investigated by the effort of many chromatographer. The high performance analysis came to be achieved
as a result.
SHINWA CHEMICAL INDUSTRIES LTD. offer the customer the column with excellent separation andreproducibility anytime and anywhere; ULTRON columns have made an effort doing a severe quality control
through the production process.
The series of ULTRON are high quality controlled HPLC columns.
In order to satisfy your analytical requirement, we have many columns.
1) ULTRON ES series are columns for enantiomer separation in the field of medicine and so on.
2) ULTRON VX series are columns based on silica material for reversed- and normal-phase chromatography.
3) ULTRON PS series are polymer based columns for the analysis of food and so on.
The STR columns are packed with perfect spherical and pure silica synthesized finely. The STR series show
excellent column performance and reproducibility in the separation for various samples.
Separation Mode
Chiral Separation Chromatography

ColumnApplication

ULTRON ES-OVM

Optical Isomers of Medicines, Pesticides

ULTRON ES-PEPSINULTRON ES-BSAULTRON ES-CDULTRON ES-PhCD
Ion Exclusion Chromatography

ULTRON PS-80H

Organic Acids and Alcohols

Ligand Exchange Chromatography

ULTRON PS-80N

Monosaccharides, Disaccharides, Alditol

ULTRON PS-80C
ULTRON PS-80P
ULTRON CI

Inositol

ULTRON CL

Glucuronic Acid

Normal-phase Chromatography

ULTRON VX-SIL

Phosphorus Liquid

Reversed-phase Chromatography

ULTRON VX-ODS

Pharmaceutical Compounds, General Organic

ULTRON VX-Octyl

Substances,
Food Additives, Pesticides, Fatty Acids and

STR ODS-II

Catecholamines

STR ODS-M

2

HPLC Column For Enantiomer Separation
The ULTRON ES series are columns for enantiomer separation.
Columns which are packed with protein immobilized silica (ULTRON ES-OVM, ULTRON ES-PEPSIN,ULTRON ES-BSA) and chemically bonded cyclodextrin (ULTRON ES-CD, ULTRON ES-PhCD).

ULTRON ES-OVM■ Characteristics① Ultron ES-OVM is a chiral separation column immobilized with ovomucoid which isstrong protein for denaturation. (US PATENT 6027648 Eisai Co., LTD.)② A wide range of chiral recognition.
③ No sample preparation for optical separation.
④ Aqueous mobile phase can be used in the separation .
⑤ A trace analysis can be performed (ng level) .
■ Applications
・ Pharmaceutical Compounds, Pesticides and Organic Compounds
Particle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)150×2.0

ULTRON ES-OVM (Narrow Bore)ULTRON ES-OVM (for Analytical)

150×4.6

5
ULTRON ES-OVM (for Analytical)

150×6.0

ULTRON ES-OVM.G (Guard Column)

10×4.0ULTRON ES-OVM (for Analytical)

250×4.6

10

ULTRON ES-OVM Prep (for Preparative)

250×20.0

ULTRON ES-OVM Prep.G (Guard Column for Preparative)

15×8.0
5×2.0

ULTRON ES-OVM (Two Guard Cartridges )5
ULTRON ES-OVM (Two Guard Cartridges)

10×4.6

Holder for Guard Cartridge (with Adaptor)

For 5×2.0 mm column

Holder for Guard Cartridge (with Adaptor)

For 10×4.6 mm column

ULTRON ES-PEPSIN■ Characteristics① ULTRON ES-PEPSIN is an enantiomer separation column immobilized with pepsin which is thepolypeptide dialytic enzyme of the pig stomach mucous membrane origin.

② ULTRON ES-PEPSIN is effective for the enantiomer separation of amino alcohols such as β-blocker
medicines.

③ The sample preparation for optical isomer separation is not necessary.
④ Aqueous mobile phase can be used in the separation.
⑤ A trace analysis can be performed (ng level).
■ Applications
・ Pharmaceutical Compounds, Pesticides and Organic Compounds
Particle Size(µm)

ColumnULTRON ES-PEPSIN (for Analytical)

Column Size
Length × Inner Diameter (mm)150×4.6

5
ULTRON ES-PEPSIN.G (Guard Column)

10×4.03

HPLC Column For Enantiomer Separation
ULTRON ES-BSA■ Characteristics① ULTRON ES-BSA is bovine serum albumin immobilized column for enantiomer separation.
② ULTRON ES-BSA is performed an excellent enantiomer separation for acidic compounds such as
arylpropionic acid drugs.

③ The sample preparation for optical isomer separation is not necessary.
④ Aqueous mobile phase can be used in the separation.
⑤ A trace analysis can be performed (ng level) .
■ Applications
・ Pharmaceutical compounds, Pesticides and Organic compounds
Particle Size(µm)

ColumnULTRON ES-BSA (for Analytical)

Column Size
Length × Inner Diameter (mm)150×4.6

7
ULTRON ES-BSA.G (Guard Column)

10×4.0ULTRON ES-CDULTRON ES-PhCDULTRON ES-CD and ULTRON ES-PhCD are enantiomeric separation columns chemically bonded with βcyclodextrin (CD) and phenylcarbamated β-cyclodextrin (PhCD), respectively.

■ Characteristics① ULTRON ES-CD and ULTRON ES-PhCD are effective for the enantiomeric separation of hydrophobic
cyclic compounds.

② Mobile phase of both reverse-phase and normal-phase modes can be used for the separation.
③ A wide range of enantiomeric compounds can be separated with ULTRON ES-CD or ULTRON ES-PhCD.
④ The columns show excellent stability and durability.
■ Applications
・ Pharmaceutical compounds, Pesticides and Organic compounds
Particle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)ULTRON ES-CD (Narrow Bore)

150×2.0

ULTRON ES-CD (for Analytical)

150×6.0
5

ULTRON ES-CD.G (Guard Column)

10×4.0ULTRON ES-CD (Two Guard Cartridges)

5×2.0

ULTRON ES-CD (Two Guard Cartridges)

10×4.6

Holder for Guard Cartridge (with Adaptor)

For 5×2.0 mm column

Holder for Guard Cartridge (with Adaptor)

For 10×4.6 mm column

ULTRON ES-PhCD (Narrow Bore)

150×2.0

ULTRON ES-PhCD (for Analytical)

150×6.0
5

ULTRON ES-PhCD.G (Guard Column)

10×4.0ULTRON ES-PhCD (Two Guard Cartridges)

5×2.0

ULTRON ES-PhCD (Two Guard Cartridges)

10×4.6

Holder for Guard Cartridge (with Adaptor)

For 5×2.0 mm column

Holder for Guard Cartridge (with Adaptor)

For 10×4.6 mm column

4HPLC Column For Organic Acid Analysis
ULTRON PS-80H
ULTRON PS-80H is HPLC column packed with sulfonic acid type polystyrene cation exchange resin for theorganic acid analysis.

■ Characteristics① ULTRON PS-80H is high speed and a high separation column by the ion suppression of the sample.
② ULTRON PS-80H shows excellent reproducibility of the retention.
③ ULTRON PS-80H is durable because of the use of mechanical strong polymer gel.
■ Applications• Aliphatic, Aromatic organic acid
• Alcohols, Aldehydes, Diols• Monitoring of the fermentation

Particle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)300×8.0

ULTRON PS-80H
10
ULTRON PS-80H.G (Guard Column)

250×2.050×8.0The maximum operation pressure : 4.0 MPa
The maximum operation temperature : 90℃
Range of pH in use : pH 2 - 6

HPLC Column For Sugar And Sugar Alcohol Analysis
ULTRON PS-80N
ULTRON PS-80C
ULTRON PS-80P
The ULTRON PS series are HPLC columns packed with sulfonic acid type polystyrene cation exchange resin
for the sugar and the sugar alcohol analysis.
There are three types of PS-80N (Na type) , PS-80C (Ca type) and PS-80P (Pb type).

■ Characteristics① ULTRON PS series columns are effective for quantity analysis because saccharide is not adsorbed on thematrix.

② ULTRON PS series columns use in aqueous mobile phase.
③ ULTRON PS series columns are durable because of the use of mechanical strong polymer gel.
■ Applications• Oligosaccharides, Disaccharides, Monosaccharides• Suger alcohols• Monitor of ferment hydrolysis of polysaccharide

5Particle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)ULTRON PS-80N

300×8.0

ULTRON PS-80N.L

500×8.0

ULTRON PS-80N.G (Guard Column)

50×8.0
１0

ULTRON PS-80C

300×8.0

ULTRON PS-80C.G (Guard Column)

50×8.0ULTRON PS-80P

300×8.0

ULTRON PS-80P.G (Guard Column)

50×8.0The maximum operation pressure : 4.0 MPa (PS-80N, -80C, -80P)
6.0 MPa (PS-80N.L)
The maximum operation temperature : 80℃ (PS-80N, -80N.L)
90℃ (PS-80C, -80P)
Range of pH in use : pH 6 - 12 (PS-80N, -80N.L),
pH 6 - 7.5 (PS-80C, -80P)

HPLC Column For Inositol In Health DrinkULTRON C I
ULTRON CI is a strong cation exchange polymer packed HPLC column for inositol.

■ Characteristics① ULTRON CI perform excellent qualitative analysis for inositol in health drink.
② ULTRON CI shows good reproducibilyty in retention.
③ The polymer beads of ULTRON CI have mechanical strength.
The maximum operation pressure is 8.0 MPa.
The maximum operation temperature is 90 ℃ .
ColumnULTRON CI

Column Size
Length × Inner Diameter (mm)200×4.6

HPLC Column For Glucuronic Acid In Heath DrinkULTRON CLULTRON CL is a strong anion exchange polymer packed HPLC column for glucuronic acid.

■ Characteristics① ULTRON CL perform excellent qualitative analysis for glucuronic acid in health drink.
② ULTRON CL shows good reproducibility in retention.
③ The polymer beads of ULTRON CI have mechanical strength.
The maximum operation pressure is 8.0 MPa.
The maximum operation temperature is 80 ℃.

ColumnULTRON CL

Column Size
Length × Inner diameter (mm)150×4.06

HPLC Column For Normal Phase (SIL)ULTRON VX-SILULTRON VX-SIL is used high purity silica gel of SiO2 99.99% or more. Therefore, the sample adsorption withthe metal oxide is decreased as much as possible.
The use of the spherical silica particles lead to reduce the column pressure drop and long life.
Particle Size

Pore Size

Specific Surface

5 µm

12 nm

300 m2/g

Particle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)150×4.6

VX-SIL (for Analytical)

5

250×4.6
150×6.0

VX-SIL (for Preparative)

5

250×20.0
150×2.0
250×2.0

VX-SIL (Narrow Bore)5
150×1.0
250×1.0
150×4.6

VX-SIL (for Analytical)

10

250×4.6
150×6.0
250×20.0

VX-SIL (for Preparative)

10

250×30.0
250×50.0

VX-SIL (for Preparative)

15

250×4.6
250×20.0

VX-SIL (for Preparative)

15

250×30.0
250×50.0

ULTRON VX-SIL.G (Guard Column)
Particle Size(µm)

ColumnVX-SIL.G (for Analytical）

Column Size
Length × Inner Diameter (mm)10×4.05
VX-SIL.G (for Preparative）

15×8.0VX-SIL.G (for Analytical）

10×4.010

VX-SIL.G (for Preparative）

15×8.0VX-SIL.G (for Analytical）

10×4.015

VX-SIL.G (for Preparative）

15×8.0VX-SIL (Two Guard Cartridges）

5×2.0
5

VX-SIL (Two Guard Cartridges）

10×4.6

Holder for Guard Cartridge (with Adaptor)

For 5×2.0 mm column

Holder for Guard Cartridge (with Adaptor)

For 10×4.6 mm column

7HPLC Column For Reversed Phase (ODS)ULTRON VX-ODSULTRON VX-ODS is reversed-phase column having monomeric octadecyl group. The bare silica of ULTRON
VX-ODS is the same of ULTRON VX-SIL. Our excellent end-capping technology (secondary silylation) lead tothe reduction of the influence of the residual silanol groups. We have three types (5, 10, and 15 μm) of theparticle diameter. We also various column from 1 mm (narrow bore) to 50 mm (for preparative separations) in
the inner diameter. Please select the column size according to the purpose.
Particle Size

Pore Size

Surface Area

Carbon Content

5 µm

12 nm

300 m2/g

16 ％Reproducibility between column lots
ULTRON VX-ODS columns are cheked by the severe quality control every each manufacturing process.
The product passed many check point in the manufacturing process is ULTRON VX-ODS. The k' and α
value obtained with ULTRON VX-ODS shows the narrow difference between the batch and column lots.
ULTRON VX-ODS shows excellent reproducibility and stability, in other test between column lots.
Stereoselectivity, distribution equilibrium
ULTRON VX-ODS which has monolayer of octadecyl group shows excellent stereoselectivity for the sample
molecule. The distribution equilibrium is performed quickly under the gradient elution or at the exchange ofthe mobile phase used.
Pressure resistance
By the use of spherical silica gel, ULTRON VX-ODS shows the excellent the resisting pressure and even atfast flow rate of mobile phase, a stable separation is obtained.
Particle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)150×4.6

VX-ODS (for Analytical)

5

250×4.6
150×6.0

VX-ODS (for Preparative)

5

250×20.0
150×2.0
250×2.0

VX-ODS (Narrow Bore)5
150×1.0
250×1.0
150×4.6

VX-ODS (for Analytical)

10

250×4.6
150×6.0
250×20.0

VX-ODS (for Preparative)

10

250×30.0
250×50.0

VX-ODS (for Analytical)

15

250×4.6
250×20.0

VX-ODS (for Preparative)

15

250×30.0
250×50.08HPLC Column For Normal Phase (ODS)ULTRON VX-ODS.G (Guard Column)
Particle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)VX-ODS.G (for Analytical）

10×4.05

VX-ODS.G (for Preparative）

15×8.0VX-ODS.G (for Analytical）

10×4.010

VX-ODS.G (for Preparative）

15×8.0VX-ODS.G (for Analytical）

10×4.015

VX-ODS.G (for Preparative）

15×8.0VX-ODS (Two Guard Cartridges）

5×2.0
5

VX-ODS (Two Guard Cartridges）

10×4.6

Holder for Guard Cartridge (with Adaptor)

For 5×2.0 mm column

Holder for Guard Cartridge (with Adaptor)

For 10×4.6 mm column

HPLC Column For Reversed Phase (Octyl)
ULTRON VX-Octyl
The earth environment is very important problem. We have to defend our earth from the atmosphericpollution, the contamination of the water, the soil pollution and the industrial waste pollution. The reduction oflarge amount of orgnic solvents is also needed in the HPLC analysis which can be performed for many
samples in the various field. In order to overcome many problems mentioned above, octyl column modified
with short alkyl chain than that of ODS column may be necessary and become popular. ULTRON VX-Octyl
have a necessary characteristics to satisfy for such requirements.
A highly refined synthetic technology of ULTRON VX-ODS was applied to ULTRON VX-Octyl.

■ Characteristics
The column life has been greatly improved.
ULTRON VX-Octyl is very few in the difference between columns lots and shows excellent reproducibility.
ULTRON VX-Octyl save the analysis time compared with ODS and shows excellent separation.
The use of organic solvent is decreased.
Because distribution equilibrium can be achieved quickly and the adsorbed material can be eluted easily
compared with ODS, The best separation can be obtained by the gradient elution.

■ Applications
・Pharmaceutical compounds, Pesticides, Chemical compounds, Food, Environmental compounds andothersParticle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)150×4.6

ULTRON VX-Octyl (for Analytical)
250×4.6
5

ULTRON VX-Octyl (for Preparative)

250×20.0

ULTRON VX-Octyl.G (Guard Column)

10×4.0ULTRON VX-Octyl.G (Guard Column for Preparative)

15×8.09

HPLC Column For Reversed Phase (STR ODS)STR ODS-II■ Characteristics① The effect of the metal oxide is suppressed minimum because of the highly-purified silica gel as a basematerial of STR series.

② STR series are durable column because of the use of mechanically strong silica gel.
③ STR series column is durable in acidic and basic mobile phase.
④ STR series are easy to operate and show high performane, because the analytical operation pressure islow.

⑤ The excellent end capping technology shows good peak shape for the bacic substances and acidic
compounds and for the samples which form complex with metal.
ColumnParticle ShapeParticle Size

Pore Size

Specific
Surface Area

Carbon Content

ODS-II

Spherical Porous Silica Gel

5 µm

12 nm

320 m2/g

17 ％Particle Size(µm)

ColumnColumn Size
Length × Inner Diameter (mm)STR ODS-Ⅱ (Narrow Bore)

150×2.0

STR ODS-Ⅱ (Narrow Bore)

250×2.0

STR ODS-Ⅱ (for Analytical)

100×4.0

STR ODS-Ⅱ (for Analytical)

150×4.0

STR ODS-Ⅱ (for Analytical)

250×4.0

STR ODS-Ⅱ (for Analytical)

150×4.6

STR ODS-Ⅱ (for Analytical)

250×4.6

STR ODS-Ⅱ (for Analytical)

150×6.0

STR ODS-Ⅱ (Guard Column)

10×4.05

STR ODS-Ⅱ (Guard Column)

10×4.6

STR ODS-Ⅱ (Guard Column)

10×6.0STR ODS-Ⅱ (for Preparative)

250×20.0

STR ODS-Ⅱ (Guard Column for Preparative)

50×20.0

STR ODS-Ⅱ PEEK (for Analytical)

150×4.6

STR ODS-Ⅱ PEEK (for Analytical)

250×4.6

STR ODS-Ⅱ PEEK (Guard Column)

10×4.6

STR ODS-Ⅱ (Two Guard Cartridges)

5×2.0

STR ODS-Ⅱ (Two Guard Cartridges)

10×4.6

Holder for Guard Cartridge (with Adaptor)

For 5×2.0 mm column

Holder for Guard Cartridge (with Adaptor)

For 10×4.6 mm column

10STR ODS-M
ColumnParticle ShapeParticle Size

Pore Size

Specific
Surface Area

Carbon Content

ODS-M

The Perfect and Spherical
Porous Silica Gel

5 µm

10 nm

350 m2/g

15 ％ColumnParticle Size(µm)

Column Size
Length × Inner Diameter (mm)STR ODS-M

150×4.0

STR ODS-M

250×4.0

STR ODS-M

150×4.6
5

STR ODS-M

250×4.6

STR ODS-M

150×6.0

STR ODS-M

10×4.0STR ODS-M

50×4.011

Application Data
ColumnPage

ULTRON ES-OVM…

13ULTRON ES-PEPSIN…

26

ULTRON ES-BSA…

27

ULTRON ES-CD…

28

ULTRON ES-PhCD…

32

ULTRON PS-80H…

37

ULTRON PS-80N ・ PS-80C ・ PS-80P…

40

ULTRON CI ・ CL…

44

ULTRON VX-SIL…

45

ULTRON VX-ODS…

46

ULTRON VX-Octyl…

49

STR ODS-Ⅱ…

50

STR ODS-M

…

58

INDEX

…

63

12

ULTRON ES-OVM
β-blockers
Arotinolol

Alprenolol

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0) / CH3CN = 100 / 5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5) / CH3CN = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

β-blockers
Bunitrolol

Oxprenolol

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0) / C2H5OH = 100 / 3
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0) / CH3CN = 100 / 10
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

13

ULTRON ES-OVM
β-blockers
Propranolol

Pindolol

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.8) / CH3CN = 100 / 30
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5) / C2H5OH = 100 / 30
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Calcium Antagonists
Bay K 8644

Prenylamine

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 25
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.0) / CH3CN = 100 / 15
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

14

ULTRON ES-OVM
Calcium Antagonists

Antiparkinsons

Verapamil

Biperiden

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Antiparkinsons
Profenamine

Trihexyphenidyl

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 25
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100/ 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

15ULTRON ES-OVM
Antiinflammatoryies
Flurbiprofen

Ibuprofen

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 3.0) / CH3CN = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 3.0) / CH3CN = 100 / 5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Antiinflammatoryies
Ketoprofen

Pranoprofen

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 3.0) / CH3CN = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 3.0) / CH3CN = 100 / 8
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

16

ULTRON ES-OVM
Antiinflammatoryies

Antihistamines

Zaltoprofen

Alimemazine

Column: ULTRON ES-OVM
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 3.0) / CH3CN = 87 / 13
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 25
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Antihistamines
Chlorpheniramine

Dimethindene Maleate

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.0) / CH3CN = 100 / 5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 100 / 9
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

17

ULTRON ES-OVM
Antihistamines
Homochlorcyclizine

Promethazine

Column: ULTRON ES-OVM
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 20
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 3.0) / CH3CN = 100 / 5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

AnticonvulsantsAcetylpheneturide

Mephobarbital

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 7.5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

18

ULTRON ES-OVM
Tranquilizers

Skeletal Muscle Relaxants

Hydroxyzine

Chlormezanone

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Skeletal Muscle Relaxants
Chlorphenesin

Eperisone

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5)
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5) / C2H5OH = 100 / 5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

19ULTRON ES-OVM
Skeletal Muscle Relaxants

AntidepressantsTolperisone

Trimipramine Maleate

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5) / C2H5OH = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.5) / C2H5OH = 100 / 30
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Central Nervous System Stimulants

Drugs Used in Vertigo
Meclizine

Methylphenidate

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.7)
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 35
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

20ULTRON ES-OVM
Hypnotics
Glutethimide

Hexobarbital

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0) / C2H5OH = 100 / 5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Anticholinergics
Glycopyrronium Bromaide

Mepenzolate Bromaide

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5) / C2H5OH = 100 / 2
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6)
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

21

ULTRON ES-OVM
Local Anesthetics

Antidysrhythmics

Bupivacaine

Disopyramid

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5) / CH3CN = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5) / C2H5OH = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Antitussives
Benproperine

Cloperastin

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 20
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 15
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

22

ULTRON ES-OVM
Diuretics

Oral Anticoagulants

Ethiazide

Warfarin

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6)
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 3.0) / CH3CN = 100 / 15
Flow Rate: 0.1 mL/min
Temperature: 25 ℃
Detection: UV-305 nm

Bronchodilators

Drugs in Peptic Ulcer

Clorprenaline

Proglumide

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5) / C2H5OH = 100 / 3
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 20
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

23

ULTRON ES-OVM
OthersFlavanone

1,2-Diphenylethylamine

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.5)
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 100 / 30
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-254 nm

Others(1S,2R)-1-Methyl-cis-1,2,3,6-tetrahydrophthalate

BenzoinColumn: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.0) / CH3CN = 100 / 5
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / C2H5OH = 100 / 10
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-250 nm

24

ULTRON ES-OVM
OthersThyroxine

Column: ULTRON ES-OVM
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 100 / 20
Flow Rate: 1.2 mL/min
Temperature: 15 ℃
Detection: UV-220 nm

25

ULTRON ES-PEPSIN
β-Blockers
Atenolol

Alprenolol

Column: ULTRON ES-PEPSIN
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.0) / C2H5OH = 95 / 5Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-PEPSIN
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0) / C2H5OH = 99 / 1
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

β-Blockers

Bronchodilators

Bunitrolol

Terbutaline

Column: ULTRON ES-PEPSIN
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.0) / C2H5OH = 95 / 5Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-PEPSIN
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0)
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

26

ULTRON ES-BSA
Antiinflammatoryies
Ibuprofen

Column: ULTRON ES-BSA
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 7.0) / 1-Propanol / Caprylic Acid = 98 / 2 / 0.08
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Antiinflammatoryies

Oral Anticoagulants
Warfarin

Pranoprofen

Column: ULTRON ES-BSA
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 7.0) / 1-Propanol /Caprylic Acid = 98 / 2 / 0.01
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-BSA
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 7.0) / 1-Propanol /Caprylic Acid = 98 / 2 / 0.01
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

27

ULTRON ES-CD
Antihistamines
Alimemazine

Chlorpheniramine

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 5.0) / CH3CN = 70 / 30
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 83 / 17
Flow Rate: 1.0 mL/min
Temperature: 15 ℃
Detection: UV-220 nm

AnticonvulsantsSkeletal Muscle Relaxants
Chlormezanone

Mephobarbital

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 80 / 20
Flow Rate: 0.6 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 93 / 7
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

28

ULTRON ES-CD
Skeletal Muscle Relaxants
Tolperisone

Eperisone

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 80 / 20
Flow Rate: 0.6 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 85 / 15
Flow Rate: 1.2 mL/min
Temperature: 7 ℃
Detection: UV-220 nm

AntidepressantsCentral Nervous System Stimulants

Trimipramine Maleate

Methylphenidate

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 75 / 25
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0) / CH3CN = 90 / 10
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

29

ULTRON ES-CD
Antipsychotic Drug

Hypnotics
Hexobarbital

Thioridazine

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 83 / 17
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 75 / 25
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Bronchodilators
Terbutaline

Clorprenaline

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 94 / 6
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0) / CH3CN = 99 / 1
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

30

ULTRON ES-CD
Diuretics

OthersEthiazide

BenzoinColumn: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 88 / 12
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 92.5 / 7.5
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

OthersFlavanone

PTH-Valine

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 80 / 20
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-CD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 3.0) / CH3CN
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

31

ULTRON ES-PhCD
β-Blockers
Alprenolol

Arotinolol

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 75 / 25
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 80 / 20
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

β-Blockers
Bunitrolol

Atenolol

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 6.0) / CH3CN = 90 / 10
Flow Rate: 0.6 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 70 / 30
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

32

ULTRON ES-PhCD
β-Blockers
Pindolol

Propranolol

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 60 / 40
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 90 / 10
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

AnticonvulsantsLocal Anesthetics
Bupivacaine

Acetylpheneturide

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 80 / 20
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 76 / 24
Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-220 nm

33

ULTRON ES-PhCD
Skeletal Muscle Relaxants
Chlormezanone

Chlorphenesin

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 70 / 30
Flow Rate: 0.6 mL/min
Temperature: 9 ℃
Detection: UV-220 nm

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 70 / 30
Flow Rate: 0.6 mL/min
Temperature: 9 ℃
Detection: UV-220 nm

Skeletal Muscle Relaxants

OthersEperisone

1,1’-Bi-2-naphthol

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 70 / 30
Flow Rate: 1.2 mL/min
Temperature: 9 ℃
Detection: UV-220 nm

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: Hexane / Dichloromethane/ Methanol= 75 / 25 / 5Flow Rate: 1.2 mL/min
Temperature: 25 ℃
Detection: UV-254 nm

34

ULTRON ES-PhCD
OthersFlavanone

N-(3,5-Dinitrobenzoyl)-α-methylbenzylamine

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: Hexane / Ethanol = 99 / 1
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-254 nm

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: Hexane / Ethanol = 85 / 15
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-254 nm

Othersα-Phenylethyl Alcohol

α-Phenylethylamine

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 90 / 10
Flow Rate: 0.6 mL/min
Temperature: 15 ℃
Detection: UV-220 nm

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 95 / 5Flow Rate: 0.6 mL/min
Temperature: 15 ℃
Detection: UV-220 nm

35

ULTRON ES-PhCD
OthersThe Relationship Between Flow Ratio and Capacitor Ratio (k') of Column Temperature, Optics Recognition Ability (α)α-Phenylethylamine

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: 20 mM KH2PO4 (pH 4.6) / CH3CN = 90 / 10
Detection: UV-220 nm

Otherstrans-Stilbene Oxide

Column: ULTRON ES-PhCD
Size: 150 mm x 6.0 mm I.D.
Mobile Phase: Hexane / Methanol = 99.9 / 0.1
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: UV-254 nm

36

ULTRON PS-80H
Elution Position of The Aliphatic Organic Acid
① Citric Acid
② Tartaric Acid
③ Glyoxylic Acid
④ Malic Acid
⑤ Malonic Acid
⑥ Succinic Acid
⑦ Glycolic Acid
⑧ Formic Acid
⑨ Lactic Acid
⑩ Acetic Acid
⑪ Fumaric Acid
⑫ Levulinic Acid
⑬ Adipic Acid
⑭ Pyroglutamic Acid
⑮ Propionic Acid
⑯ Acrylic Acid
⑰ Pivalic Acid
⑱ Methacrylic Acid
⑲ Crotonic Acid
Column: ULTRON PS-80H
Size: 300 mm x 8.0 mm I.D.
Mobile Phase: HClO4aq. (pH2.1)
Flow Rate: 1.0 mL/min
Temperature: 60 ℃
Detection: UV-210 nm

Elution Position of The Aromatic Organic Acid

① Citric Acid
② Tartaric Acid
③ Malonic Acid
④ Succinic Acid
⑤ Lactic Acid
⑥ Acetic Acid
⑦ Gallic Acid
⑧ Propionic Acid
⑨ o-Phthalic Acid
⑩ Phenoxyacetic Acid
⑪ m-Hydroxybenzoic Acid
⑫ p-Hydroxybenzoic Acid
⑬ Vanilic Acid
⑭ Sorbic Acid
⑮ Caffeic Acid
⑯ Benzoic Acid
⑰ o-Hydroxybenzoic Acid

Column: ULTRON PS-80H
Size: 300 mm x 8.0 mm I.D.
Mobile Phase: 10 % CH3CN Addition HClO4aq. (pH2.1)
Flow Rate: 1.0 mL/min
Temperature: 60 ℃
Detection: UV-210 nm

37

ULTRON PS-80H
Alcohols Aldehydes

Alcohols① Ethylene Glycol② Diethylene Glycol③ Methanol④ Ethanol⑤ Isopropyl Alcohol① Formaldehyde② Acetaldehyde③ Ethanol

Column: ULTRON PS-80H
Size: 300 mm x 8.0 mm I.D.
Mobile Phase: H2O
Flow Rate: 1.0 mL/min
Temperature: 60 ℃
Pressure: 25 kgf/cm2
Detection: RI, 32x10-6 RIUFS
Inj. Vol.: 6.0 uL (10 mg/mL)

Column: ULTRON PS-80H
Size: 300 mm x 8.0 mm I.D. + 50 mm x 8.0 mm I.D.
Mobile Phase: HClO4aq (pH 2.1)
Flow Rate: 1.0 mL/min
Temperature: 60 ℃
Pressure: 25 kgf/cm2
Detection: RI, 32x10-6 RIUFS

Uronic Acid, Acetylation Amino Sugar

Analysis of The Soy Sauce① Glucuronic Acid
② N-Acetylglucosamine③ N-Acetylgalactosamine① Citric Acid
② Tartaric Acid
③ Malic Acid
④ Succinic Acid
⑤ Lactic Acid
⑥ Acetic Acid
⑦ Pyroglutamic Acid

Column: ULTRON PS-80H
Size: 300 mm x 8.0 mm I.D.
Mobile Phase: HClO4aq (pH 2.1)
Flow Rate: 1.0 mL/min
Temperature: 60 ℃
Detection: UV-210 nm

Column: ULTRON PS-80H
Size: 300 mm x 8.0 mm I.D. + 50 mm x 8.0 mm I.D.
Mobile Phase: HClO4aq (pH 2.1)
Flow Rate: 1.0 mL/min
Temperature: 60 ℃
Pressure: 25 kgf/cm2
Detection: UV-210 nm

38

ULTRON PS-80H
Analysis of Aliphatic Organic Acid③

① Citric Acid
② Tartaric Acid
③ Maleic Acid
④ Malonic Acid
⑤ Succinic Acid
⑥ Glycolic Acid
⑦ Lactic Acid
⑧ Fumaric Acid
⑨ Acetic Acid
⑩ Adipic Acid
⑪ Propionic Acid
⑫ Methacrylic Acid
⑬ Crotonic Acid

⑧

②

⑬
④
⑥

⑨

⑦
⑤
①

⑫
⑪
⑩

5

10

15

20

Column: ULTRON PS-80H
Size: 250 mm x 2.0 mm I.D.
Mobile Phase: HClO4aq (pH 2.1)
Flow Rate: 0.05 mL/min(min)

Temperature: 60 ℃
Press.:0.7 MPa
Injection Amount: 2.5 uL
Detection: UV-210 nm

Mass Chromatograms Obtained by TIC of 11 Carboxylic Acids.

9.22e4

Column : ULTRON PS-80H
Dimensions : 250 mm L × 2.0 mm I.D.
Mobile Phase : 0.1％ Formic Acid (pH 2.3)
Flow Rate : 0.07 ml/min
Temperature : 55℃
Detection : ESI Positive and Negative, Range: m/z 50〜350

5.91

2-Ketoglutaric Acidm/z=14503.32e5

Malonic Acid

9.58

6.90

DL-2-Hydroxy-n-butyric Acidm/z=10301.45e5

8.37

Glycolic Acidm/z=7502.02e5

8.40

Succinic Acidm/z=11701.19e5

8.77

Fumaric Acidm/z=11505.86e5

L-(+)-Lactic Acid

8.81

m/z=8901.66e5Glutaric Acid

9.25

m/z=13101.57e4

Acetic Acid

9.82

m/z=7801.97e4

11.06

Propionic Acidm/z=9202.59e4

13.04

n-Butyric Acidm/z=106

0

5

10

15

(min)

39

ULTRON PS-80N ・ PS-80C ・ PS-80P
Elution Position of Sugar and Sugar Alcohol for PS-80N① Dextran T-10
② Raffinose③ Lactose④ Glucose⑤ Galactose⑥ Arabinose⑦ Ethanol

Temperature: 60 ℃

Column: ULTRON PS-80N
Size: 300 mm x 8.0 mm I.D.

Detection: RI, 16x10-5 RIUFS

Mobile Phase: H2O

Sample: ea. 15 mg/mL, Ethanol 50 uL/mL

Flow Rate: 1.0 mL/min

Elution Position of Sugar and Sugar Alcohol for PS-80C① Dextran T-10
② Raffinose③ Sucrose④ Glucose⑤ Galactose⑥ Fructose⑦ Adonitol⑧ Glycerol⑨ Ethanol + Mannitol⑩ Xylitol +Sorbitol

Temperature: 80 ℃

Column: ULTRON PS-80C
Size: 300 mm x 8.0 mm I.D.

Detection: RI, 16x10-5 RIUFS

Mobile Phase: H2O

Sample: ea. 10 uL/mL

Flow Rate: 1.0 mL/min

40

ULTRON PS-80N ・ PS-80C ・ PS-80P
Elution Position of Sugar and Sugar Alcohol for PS-80P① Dextran T-10
② Raffinose③ Sucrose④ Lactose⑤ Glucose⑥ Xylose⑦ Galactose⑧ Arabinose⑨ Fructose⑩ Ethanol⑪ Glycerol⑫ Mannitol⑬ Xylitol⑭ Sorbitol

Temperature: 80 ℃
Column: ULTRON PS-80P

Size: 300 mm x 8.0 mm I.D.

Detection: RI, 16x10-5 RIUFS
Mobile Phase: H2O

Sample: ea. 10 uL/mL
Flow Rate: 1.0 mL/min

Retention Index of The Standard Sample

Ethanol

Ethylene Glycol
Diethylene Glycol

GlycerolArabinose
Xylitol
Inositol
Fructose
XyloseMannose
Galactose
Sorbitol
AdonitolMannitolGlucoseLactoseMaltoseSucroseRaffinose

Maltotriose

Dextran T-10

Sorbitol
Xylitol

Diethylene Glycol

GlycerolEthanolMannitol
Ethylene Glycol

Adonitol

Arabinose
Inositol
Fructose

Mannose

Galactose
XyloseGlucoseLactoseMaltoseSucroseMaltotriose
Raffinose

Dextran T-10

Sorbitol

Xylitol

Diethylene Glycol
Mannitol

Ethanol

AdonitolInositol
GlycerolEthylene Glycol

Fructose
MannoseArabinose

XyloseGalactose

GlucoseLactoseMaltoseSucroseMaltotriose
Raffinose

Dextran T-10

41

ULTRON PS-80N ・ PS-80C ・ PS-80P
Sugar and Sugar Alcohol① Sucrose② Lactose③ Glucose④ Xylosel⑤ Galactose⑥ Fructose⑦ Inositol

④
⑤
⑦
③
①

②

⑥

Temperature: 80 ℃

Column: ULTRON PS-80P
Size: 300 mm x 8.0 mm I.D. + 300 mm x 8.0 mm I.D.

Pressure: 20 kgf/cm2

Mobile Phase: H2O

Detection: RI, 16x10-5 RIUFS

Flow Rate: 1.0 mL/min

Comparison of Retention Between PS-80N 300 mm × 8.0 mm and 500 mm × 8.0 mm

②

③

④

⑤

① Dextran T-10
② Maltotriose③ Maltose④ Glucose⑤ Galactose⑥ Inositol⑦ Ethanol⑥⑦①

Column: ULTRON PS-80N
Size: 300 mm x 8.0 mm I.D.
Mobile Phase: H2O
Flow Rate: 1.0 mL/min
Pressure: 20 kgf/cm2

②
①

③

④

⑤

⑥
⑦

Column: ULTRON PS-80N･L
Size: 500 mm x 8.0 mm I.D.
Mobile Phase: H2O
Flow Rate: 1.0 mL/min
Pressure: 35 kgf/cm2

42

ULTRON PS-80N ・ PS-80C ・ PS-80P
SakeStarch Syrup① Oligosaccharide② Maltotriose③ Maltose④ Glucose① Maltotriose② Maltose③ Glucose④ Glycerol⑤ Ethanol

Column: ULTRON PS-80N

Temperature: 60 ℃

Column: ULTRON PS-80N

Size: 300 mm x 8.0 mm I.D.

Pressure: 22 kgf/cm2

Size: 300 mm x 8.0 mm I.D. Pressure: 22 kgf/cm2

Mobile Phase: H2O

Detection: RI, 16x10-5 RIUFS

Mobile Phase: H2O

Detection: RI, 16x10-5 RIUFS

Flow Rate: 1.0 mL/min

Injection Vol.: 10 uL

Flow Rate: 1.0 mL/min

Injection Vol.: 5 uL(25 mg/mL)

Separation of Stachyose and Raffinose

Yoghurt Drink① Sucrose② Lactose③ Glucose④ Galactose⑤ Fructose① Stachyose② Raffinose③ Glucose

Column: ULTRON PS-80N

Temperature: 60 ℃

Size: 300 mm x 8.0 mm I.D. Pressure: 25 kgf/cm

Temperature: 60 ℃

Column: ULTRON PS-80C
2

Pressure: 20 kgf/cm2
Detection: RI, 8x10-5 RIUFS
Injection Vol.: 10 uL

Mobile Phase: H2O

Detection: RI, 128x10 RIUFS

Mobile Phase: H2O

Flow Rate: 1.0 mL/min

Injection Vol.: 10 uL(2 mg/mL)

Flow Rate: 0.5 mL/min-643

Temperature: 80 ℃

Size: 300 mm x 8.0 mm I.D.

ULTRON CI ・ CL
Inositol in Health Drink

Health Drink R

Health Drink RS

InositolInositolInositol

Column: ULTRON CI

Flow Rate: 1.0 mL/min

Size: 200 mm x 4.6 mm I.D.

Temperature: 40 ℃

Mobile Phase: CH3CN / H2O = 60 / 40

Detection: RI

Glucuronic Acid in Health Drink

L-sodium Glutaminate, Glucuronic Acid①

Health Drink C① Ｌ-Glutamic Acid Monosodium Solt

① Glucuronic Acid

② Glucuronic Acid②①

Column: ULTRON CL

Flow Rate: 0.8 mL/min

Size: 150 mm x 4.0 mm I.D.

Temperature: 70 ℃

Mobile Phase: 20mM KH2PO4

Detection: UV-210 nm

44

ULTRON VX-SIL
Female Sex Hormone

The Fat-soluble Vitamins① Vitamin A Palmitate② Vitamin K1③ Vitamin K2④ Vitamin A Acetate⑤ Vitamin E① Estrone② Estradiol③ Estriol

Column: ULTRON VX-SIL
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: n-Hexane / Ethanol = 90 / 10
Flow Rate: 1.0 mL/min
Temperature: Ambient
Detection: UV-280 nm

Column: ULTRON VX-SIL
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: n-Hexane / Dichloromethane = 90 / 10
Flow Rate: 1.0 mL/min
Temperature: Ambient
Detection: UV-254 nm

45

ULTRON VX-ODS
Pyridine, Phenol Test

Acidic Compounds① p-Hydroxybenzoic Acid
② m-Hydroxybenzoic Acid
③ Phenol④ Acetylsalicylic Acid
⑤ Benzoic Acid
⑥ Salicylic Acid

① Pyridine② PhenolColumn: ULTRON VX-ODS
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: CH3CN / H2O = 30 / 70
Flow Rate: 1.0 mL/min
Temperature: 30 ℃
Detection: UV-254 nm

Column: ULTRON VX-ODS
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM (NH4)3PO4 （pH 2.5）/
CH3CN = 80 / 20
Flow Rate: 1.0 mL/min
Temperature: 30 ℃
Detection: UV-254 nm

Separation of The Steroid

The Water-soluble Vitamin① Predonisone② Cortisone③ Hydrocortisone④ Cortisone Acetate⑤ Hydrocortisone Acetate① Nicotinic Acid
② Nicotinic Acid Amide③ Calcium Pantothenate④ Pyridoxine Hydrochloride⑤ Riboflavin Phosphate⑥ Thiamine⑦ Folic Acid
⑧ Biotin⑨ Riboflavin

Column: ULTRON VX-ODS
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM H3PO4 /5 mM CH3(CH2)5SO3Na= 91 / 9
Flow Rate: 1.0 mL/min
Temperature: 45 ℃
Detection: UV-210 nm

Column: ULTRON VX-ODS
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: H2O / CH3OH / THF = 70 / 10 / 20
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-254 nm

46

ULTRON VX-ODS
The Synthetic Antibacterial Medicine Simultaneity Analysis① Amprolium② Sulfamerazine③ Sulfadimidine④ Thiamphenicol⑤ Furazolidone⑥ Oxytetracycline⑦ Sulfamonomethoxine⑧ Oxolinic Acid
⑨ Sulfadimethoxine⑩ Sulfaquinoxaline

Column: ULTRON VX-ODS 5 µm
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: Ａ 10 mM TFA
B CH3CN
Flow Rate: 1.0 mL/min
Temperature: 40 ℃

Synthetic Antibacterial Medicine Repeat Test
① Amprolium② Sulfamerazine③ Sulfadimidine④ Thiamphenicol⑤ Furazolidone⑥ Oxytetracycline⑦ Sulfamonomethoxine⑧ Oxolinic Acid
⑨ Sulfadimethoxine⑩ Sulfaquinoxaline

Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-254 nm

Column: ULTRON VX-ODS 5 µm
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: Ａ 10 mM TFA
B CH3CN

47

ULTRON VX-ODS
Chromatogram of The Repeat Test
① Amprolium② Sulfamerazine③ Sulfadimidine④ Thiamphenicol⑤ Furazolidone⑥ Oxytetracycline⑦ Sulfamonomethoxine⑧ Oxolinic Acid
⑨ Sulfadimethoxine⑩ Sulfaquinoxaline

Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-254 nm

Column: ULTRON VX-ODS 5 µm
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: Ａ 10 mM TFA
B CH3CN

Naphthalene

Pyridine, Phenol Test

Naphthalene

PhenolColumn: ULTRON VX-ODS
Size: 150 mm x 2.1 mm I.D.
Mobile Phase: CH3CN/H2O=70/30
Flow Rate: 0.2 mL/min
Temperature: Ambient
Detection: UV-254nm,0.16AUFS
Pressure: 66 MPa

5

START

10

5

START

Pyridine

Column: ULTRON VX-ODS
Size: 150 mm x 2.1 mm I.D.
Mobile Phase: CH3CN/H2O=30/70
Flow Rate: 0.2 mL/min
Temperature: Ambient
Detection: UV-254nm,0.16AUFS
Pressure: 44 MPa

48

ULTRON VX-Octyl
Life Test in Acidic Solution

Reproducibility
Between Syntheses Lots

Life Test in Acidic Solution
Mobile Phase :60 % Methanol, 0.1 %TFA(pH2.2)

Eluent Condition : 70 % Methanol
Flow Rate : 1.0 ml/min 40 ℃
Sample : Naphthalene

Comparison of Alkylbenzene in VX-Octyl and VX-ODS
Alkyl Benzene

Column: ULTRON VX-Octyl 5 µm
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: CH3OH/H2O

Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-254 nm

49STR ODS-Ⅱ
Nucleic Acid Base, Nucleoside

Nucleoside, Nucleotide① Cytidine 5'-Monophosphate② Uridine 5'-Monophosphate③ Guanosine 5'-Monophosphate④ Adenosine 5'-Triphosphate⑤ Cytidine⑥ Uridine⑦ Adenosine 5'-Monophosphate⑧ Inosine⑨ Guanosine① Cytosine② Uracil③ Guanine④ Adenine⑤ Cytidine⑥ Uridine⑦ Thymine⑧ Adenosine⑨ Guanosine⑩ Thymidine

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 0.1 M-Phosphate Buffer (pH2.1)
0.2 M NaClO4
Flow Rate: 1.0 mL/min
Temperature: 50 ℃
Detection: UV-260 nm (0.32 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 0.1 M KH2PO4 (pH5.8)
0.2 mM Na2SO4
Flow Rate: 1.0 mL/min
Temperature: Ambient
Detection: UV-254 nm (0.32 AUFS)

NAD, NADH

Catecholamine① Norepinephrine② Epinephrine③ Normetanephrine④ 3,4-Dihydroxyphenylacetic Acid
⑤ Dopamine⑥ 5-Hydroxyindole-3-acetic Acid
⑦ Isoproterenol⑧ Homovanilic Acid
⑨ 5-Hydroxytryptamine① Nicotinamide Adenine
Dinucleotide Oxidized② Nicotinamide Adenine
Dinucleotide Reduced

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM NH4H2PO4 (pH 2.6)
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-260 nm (0.04 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 0.1M Citric Acid, 0.1M Sodium Acetate(pH4)/ 17% CH3OH 1-Octane Sodium Sulphonate
160mg/L EDTA 5mg/L
Flow Rate: 1.0 mL/min
Temperature: 25 ℃
Detection: ECD, 800 mV, 10 nA

50

STR ODS-Ⅱ
Bile Acid

Hippuric Acid
① Cholic Acid
② Glucocholic Acid
③ Taurocholic Acid
④ Chenodeoxycholic Acid
⑤ Glucochenodeoxycholic Acid
⑥ Deoxycholic Acid
⑦ Taurochenodeoxycholic Acid
⑧ Taurodeoxycholic Acid

① Hippuric Acid
② o-Methyl Hippuric Acid
③ p-Methyl Hippuric Acid
④ m-Methyl Hippuric Acid

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: CH3CN/30 mM (NH4)2HPO4(pH 7.2 NH4H2PO4) A = 10/90, B = 50/50
30 % B → 85 % B (55 min)Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-217 nm (0.02 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 20 mM-Phosphate Buffer (pH2.5)
10 mM β-Cyclodextrin
CH3CN
Flow Rate: 1.0 mL/min
Temperature: 50 ℃
Detection: UV-260 nm (0.02 AUFS)

Analysis of The PTC Amino Acid
① Aspartic Acid
② Glutamic Acid
③ Serine④ Glycine⑤ Histidine⑥ Arginine⑦ Threonine⑧ Alanine⑨ Proline⑩ Tyrosine⑪ Valine⑫ Methionine⑬ Cysteinecysteine⑭ Isoleucine⑮ Leucine⑯ Phenylalanine⑰ Lysine

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: A: Sodium Acetate (pH 6.5) / CH3CN (93:7)
B: CH3CN / H2O (4:1)
0 % B → 34 % B (18 min) →100 % B (18.01 min) → 100 % B (23 min)51

Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-254 nm (0.04 AUFS)

8
1

STR ODS-ⅡThe Water-soluble Vitamin Ⅰ

The Water-soluble Vitamin Ⅱ① Nicotinic Acid
② Nicotinamide③ Pantothenic Acid
④ Pyridoxine⑤ Riboflavin Phosphate⑥ Thiamine⑦ Caffeine⑧ Folic Acid
⑨ Biotin⑩ Riboflavin

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 100 mM-Phosphate Buffer (pH2.1)
0.8 mM Octane Sodium Sulphonate
CH3CN
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-210 nm (0.16 AUFS)① Pyridoxal② Pyridoxine③ Pyridoxamine

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 100 mM-Phosphate Buffer (pH2.1) 9
50 mM Hexane Sodium Sulphonate
CH3CN
1
Flow Rate: 1.0 mL/min
Temperature: 45 ℃
Detection: UV-210 nm (0.04 AUFS)

91

Fat-soluble Vitamin

The Freshness K Value① Vitamin A② Vitamin D2③ Vitamin D3④ Vitamin E⑤ Tocopherol Acetate① Hypoxanthine② Inosine 5'-Monophosphate③ Adenosine 5'-Diphosphate④ Adenosine 5'-Monophosphate⑤ Inosine⑥ Adenosine 5'-Triphosphate

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 24mM 2-Diethylaminoethanol is contained
16mM Citric Acid Aqueous Solution
Flow Rate: 2.0 mL/min
Temperature: 40 ℃
Detection: UV-250 nm (0.04 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 100 % CH3CN
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-280 nm (0.08 AUFS)

52

STR ODS-Ⅱ
Organic Acids

Saccharin, Aspartame, Benzoic Acid, Sorbic Acid
① Tartaric Acid
② Malic Acid
③ Malonic Acid
④ Acetic Acid
⑤ Citric Acid
⑥ Succinic Acid
⑦ Malic Acid Degradate⑨ Propionic Acid

① Saccharin② Aspartame③ Benzoic Acid
④ Sorbic Acid

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 40 mM Acetate Buffer (pH4.0)
CH3OH
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-250 nm (0.16 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 5ｍM NH4H2PO4 (pH 2.4)
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-210 nm (0.08 AUFS)

3
1

Paraben(It is added to the soy sauce of the marketing.)

The Phenolic System Antioxidant(It is added to the edible oil of the marketing.)① Methyl Paraben② Ethyl Paraben③ Isopropyl Paraben④ Propyl Paraben⑤ Isobutyl Paraben⑥ Butyl Paraben① Prostaglandin② 2,4,5-Trihydroxybutyrophenone③ Nordihydroguaiaretic Acid
④ Butyl Hydroxy Anisol⑤ Octyl Gallate⑥ 2,6-Di-t-butyl-4-hydroxy-methylphenol⑦ Lauryl Gallate⑧ 2,6-Di-t-butylhydroxytoluene

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: A: 10 mM-Phosphate Buffer (pH2.6)
B: CH3CN
30 % B → 30 % B (4 min) → 63 % B (4.01 min) →63 % B (10 min) → 90 % (10.01 min ) →90 % B (16 min) → 30 % B (16.01 min) →30 % B (25 min)Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: SPD-10A, 280 nm 2AU/V, AT = 7

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM-Phosphate Buffer (pH2.6)
CH3OH
Flow Rate: 1.5 mL/min
Temperature: 40 ℃
Detection: SPD-10A, 270 nm 2AU/V, AT = 6

53STR ODS-Ⅱ
Anticonvulsant Analysis

The Component of The Anti-inflammatory Agent① Ethosuximide② Primidone③ Phenobarbital④ Phenytoin⑤ Carbamazepine① Salicylic Acid
② Diphenhydramine③ Methyl Salicylate④ α-Camphor⑤ ThymolColumn: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM-Phosphate Buffer (pH2.6)
20 mM Heptane Sodium Sulphonate
CH3OH
CH3CN
Flow Rate: 1.0 mL/min
Temperature: 45 ℃
Detection: UV-210 nm (0.08 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 100 mM Phosphoric Acid Buffer (pH4.0)/ CH3OH / CH3CN (4 / 2 / 1)
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-250 nm (0.16 AUFS)

32
2

The Component of The Cold Remedy Ⅱ

The Component of The Cold Remedy Ⅰ① Acetaminophen② Caffeine③ Riboflavin④ Phenol⑤ Potassium Guaiacol-4-sulfonate① Methylephedrine Hydrochloride② Noscapine③ Thiamine④ Dextromethorphan⑤ Carbinoxamine Maleate

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: CH3CN
H2O
H3PO4
0.5 % Sodium Dodecyl Sulfate
Flow Rate: 1.0 mL/min
Temperature: 50 ℃
Detection: UV-210 nm (0.04 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
15
Mobile Phase: H2O
2
CH3CN
50 mM Tetrabutylammonium
1(It is adjusted at pH=6 in The Phosphoric Acid)
Flow Rate: 1.0 mL/min
Temperature: 50 ℃
Detection: UV-280 nm (0.01 AUFS)

510
490
1

54

STR ODS-Ⅱ
Oxine Copper

Thiuram① Thiuram① Oxine-copper

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 50 mM-Phosphate Buffer (pH2.2)
CH3CN
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-240 nm (0.04 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: CH3CN
50
H2O
50
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-280 nm (0.01 AUFS)

95
5

Iprodione, Bensulide

Asulam

① Iprodione② Bensulide① Asulam

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 50 mM-Phosphate Buffer (pH3.3)
CH3CN
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-270 nm (0.01 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
60
Mobile Phase: CH3CN
H2O
40
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-230 nm (0.02 AUFS)

90
10

55

STR ODS-Ⅱ
Arbutin in The Bearberry Leaf End

Berberine in The Coptis End① Berberine① Arbutin② Unknow③ Hydroquinone④ Gallic Acid

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 100 mM-Phosphate Buffer (pH2.1)
CH3OH
Flow Rate: 0.9 mL/min
Temperature: 35 ℃
Detection: UV-280 nm (0.16 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: The Result of Dissolving Potassium
Dihydrogenphosphate 3.4g and Sodium
Lauryl Sulfate 1.7g at Water 1L/CH3CN=1 / 1
Flow Rate: 0.5 mL/min
Temperature: 40 ℃
Detection: UV-345 nm (0.16 AUFS)

40
1

Glycyrrhizin in The Licorice End

Paeoniflorin in The Peony End① Paeoniflorin① Glycyrrhetic Acid
② Propyl Paraben

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 15 Times Dilution Acetic Acid
Aqueous Solution
CH3CN
Flow Rate: 0.7 mL/min
Temperature: Ambient
Detection: UV-254 nm (0.08 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM Sodium Acetate (pH 4.8)
Ch3CN
Flow Rate: 0.5 mL/min
Temperature: 40 ℃
Detection: UV-230 nm (0.64 AUFS)

3
2

56

5
1

STR ODS-Ⅱ
Scopolamine and Hyoscyamus Niger Thiamine in
The Rohto Extract

Strychnine in Nux Vomica① Scopolamine② Hyoscyamine③ Brucine① Strychnine

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: (The Result of Dissolving Potassium
Dihydrogenphosphate 6.8g in Water 1000mL) /Acetonitrile/Triethylamine=45/5/1 The Result of
Adjusting at pH=3 in The Phosphoric Acid
Flow Rate: 0.5 mL/min
Temperature: 40 ℃
Detection: UV-210 nm (0.16 AUFS)

Column: STR ODS-Ⅱ
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: The Liquid by Adding Water after It
Dissolved Potassium Dihydrogenphosphate
6.8g at Water 900 mL and Added Triethylamine
10 mL, and after It Adjusted It in The Phosphoric
Acid in pH3.5 as 1000mL/CH3CN=9/1
Flow Rate: 0.8 mL/min
Temperature: Ambient
Detection: UV-210 nm (0.16 AUFS)

57

STR ODS-M
AMP, ADP, ATP

Nucleoside, Nucleotide① Cytidine 5ʼ-Diphosphate② Cytidine 5ʼ-Monophosphate③ Uridine 5ʼ-Monophosphate④ Guanosine 5ʼ-Monophosphate⑤ Adenosine 5ʼ-Triphosphate⑥ Gytidine⑦ Uridine⑧ Adenosine 5ʼ-Monophosphate⑨ Inosine⑩ Guanosine① Adenosine 5ʼ-Monophosphate② Adenosine 5ʼ-Diphosphate③ Adenosine 5ʼ-Triphosphate

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 30 mM 2-Diethylaminoethanol is contained
20 mM Citric Acid Aqueous Solution
Flow Rate: 0.8 mL/min
Temperature: 40 ℃
Detection: UV-260 nm

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 0.1 M KH2PO4 , 20 mM Na2SO4 (pH 5.8)
Flow Rate: 1.0 mL/min
Temperature: 30 ℃
Detection: UV-254 nm

The Water-soluble Vitamin

The Freshness K Value① Hypoxanthine② Inosine 5ʼ-Monophosphate③ Adenosine 5ʼ-Monophosphate④ Adenosine 5ʼ-Diphosphate⑤ Adenosine 5ʼ-Triphosphate⑥ Isosine① Nicotinic Acid
② Nicotinamide③ Pantothenic Acid
④ Pyridoxine⑤ Riboflavin Phosphate⑥ Thiamine⑦ Caffeine⑧ Biotin⑨ Riboflavin

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 24 mM 2-Diethylaminoethanol is contained
16 mM Citric Acid Aqueous Solution
Flow Rate: 2.0 mL/min
Temperature: 40 ℃
Detection: UV-250 nm

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 100 mM-Phosphate Buffer (pH2.1)
0.9 mM Octane Sodium Sulphonate
CH3CN
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-210 nm

58

9
1

STR ODS-M
Organic Acids

Caffeine and Catechin① Tartaric Acid
② Malic Acid
③ Malonic Acid
④ Acetic Acid
⑤ Citric Acid
⑥ Succinic Acid
⑦ Malic Acid Degradate⑨ Propionic Acid

① Epigallocatechin② Catechin③ Caffeine④ Epigallocatechin Gallate⑤ Epicatechin⑥ Epicatechin Gallate

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: A: 10 mM-Phosphate Buffer (pH2.6)
B: CH3CN
7 % B → 7 % B (30 min) → 12 % B (30.01 min) →12 % B (45 min) → 50 % B (45.01 min ) →50 % B (50 min) → 7 % B (50.01 min) →7 % B (80 min)Flow Rate: 1.0 mL/min
Temperature: 45 ℃
Detection: UV-280 nm (0.64 AUFS)

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM NH2PO4(It is adjusted at pH=2.3 in The Phosphoric Acid)
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-210 nm

AnticoNvulsant Analysis

Saccharin, Aspartame, Benzoic Acid, Sorbic Acid
① Saccharin② Aspartame③ Benzoic Acid
④ Sorbic Acid

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 40 mM Acetate Buffer (pH4.0)
CH3OH
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-250 nm (0.32 AUFS)① Ethosuximide② Primidone③ Phenobarbital④ Phenytoin⑤ Carbamazepine

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 100 mM-Phosphate Buffer (pH2.1) 4
CH3OH
2
CH3CN
1
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-205 nm

3
1

59

STR ODS-M
Nicarbazin

Ethopabate① Ethopabate① Nicarbazin

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM-Phosphate Buffer (pH2.6)
CH3CN
Flow Rate: 0.8 mL/min
Temperature: 40 ℃
Detection: UV-340 nm

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: H2O
CH3CN
Flow Rate: 0.7 mL/min
Temperature: 40 ℃
Detection: UV-270 nm

30
70

70
30

Berberine①Berberine①

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: The Result of Dissolving Potassium
Dihydrogenphosphate 3.4g and Sodium
Lauryl Sulfate 1.7g at Water 1L / CH3CN=1 / 1
Flow Rate: 0.6 mL/min
Temperature: 40 ℃
Detection: UV-345 nm

60②

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM-Phosphate Buffer (pH 2.6)
200 mM NaClO4
CH3CN
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-345 nm

53

STR ODS-M
Scopolanime, Hyoscyamine① Scopolanime② Hyoscyamine③ Brucine①

Column: STR ODS-M Size: 150 mm x 4.6 mm I.D.
Mobile Phase: The Liquid by Adding Water after It
Dissolved Potassium Dihydrogenphosphate
6.8g at Water 900 mL and Added Triethylamine
10 mL, and after It Adjusted It in The Phosphoric
Acid in pH3.5 as 1000 mL / CH3CN = 9 / 1
Flow Rate: 0.8 mL/min
Temperature: ambient
Detection: UV-210 nm②

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 10 mM-Phosphate Buffer (pH 2.6)
200 mM NaClO4
CH3CN
Flow Rate: 1.0 mL/min
Temperature: 40 ℃
Detection: UV-210 nm

Arbutin① Arbutin② Hydroquinone③ Gallic Acid①②

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: H2O / CH3OH / 0.1N-HCl = 94 / 5 / 1
Flow Rate: 0.8 mL/min
Temperature: Ambient
Detection: UV-280 nm

61Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: 100 mM-Phosphate Buffer (pH 2.1)
/ CH3OH = 40 / 1
Flow Rate: 0.8 mL/min
Temperature: 40 ℃
Detection: UV-280 nm

31

STR ODS-M
Aldehydes (1.3-Cyclohexanedione Derivatives)① Formaldehyde② Acetaldehyde

Column: STR ODS-M
Size: 150 mm x 4.6 mm I.D.
Mobile Phase: CH3CN / H2O = 35 / 65
Flow Rate: 0.8 mL/min
Temperature: 40 ℃
Detection: RF-535 Ex = 360 nm Em = 440 nm

62

INDEX
A

B

Acetaldehyde

38, 62Butyl Paraben

53

Acetaminophen

54

n-Butyric Acid

39

Acetic Acid37, 38, 39, 53, 59

N-Acetylgalactosamine

38

Caffeic Acid

37

N-Acetylglucosamine

38

Caffeine

52, 54, 58, 59

Acetylpheneturide18, 33

Calcium Pantothenate

46

Acetylsalicylic Acid46

α-Camphor

54

Acrylic Acid

37

Carbamazepine

54, 59Adenine50

Carboxylic Acids

39

Adenosine

50

Catechin59

Adenosine 5’-Diphosphate

52, 58Chenodeoxycholic Acid

51

Adenosine 5’-Monophosphate

50, 52, 58

Chlormezanone

19, 28, 34

Adenosine 5’-Triphosphate

50, 52, 58

Chlorphenesin

19, 34

Adipic Acid37, 39Chlorpheniramine

17, 28

Adonitol

40, 41

Cholic Acid

51

Alanine51

Citric Acid37, 38, 39, 53, 59

Alimemazine

17, 28

Cloperastin

22

Alkylbenzene

49

Clorprenaline

23, 30

Alprenolol

13, 26, 32

Cortisone46

Amprolium

47, 48Cortisone Acetate46

Arabinose40, 41

Crotonic Acid37, 39

Arbutin56, 61

Cysteine

51

Arginine

51

Cytidine

50

Arotinolol

13, 32Ｃytidine

58

Aspartame53, 59Cytidine 5’-Diphosphate

58

Aspartic Acid

51

Cytidine 5’-Monophosphate

50, 58Asulam55

Cytosine

50

Atenolol

26, 32C

D

B

Deoxycholic Acid

51

Benproperine

22

Dextran T-10

40, 41, 42

Bensulide55

Dextromethorphan

54

Benzoic Acid37, 46, 53, 59

2,6-Di-t-butyl-4-hydroxy-methylphenol

53

Benzoin24, 31

2,6-Di-t-butylhydroxytoluene

53

Berberine

56, 60

Diethylene Glycol

38, 411,1‘-Bi-2-naphthol

34

3,4-Dihydroxyphenylacetic Acid50

Biotin46, 52, 58

Dimethindene Maleate

17

Biperiden

15

Brucine57, 61N-(3,5-Dinitrobenzoyl)-αmethylbenzylamine

35

Bunitrolol

13, 26, 32

Diphenhydramine

54

Bupivacaine

22, 33

1,2-Diphenylethylamine

24

Butyl Hydroxy Anisol

53

Disopyramid

22

Dopamine

50

63

INDEX
G

E
Eperisone

19, 29, 34

Glyoxylic Acid

36

Epicatechin

59

Guanine49

Epicatechin Gallate

59

Guanosine49, 57

Epigallocatechin

59

Guanosine 5’-Monophosphate49, 57

Epigallocatechin Gallate

59

Epinephrine

50

Hexobarbital

21, 30Estradiol45

Hippuric Acid

51

Estriol

45

Histidine

51

Estrone45

Homochlorcyclizine

18

Ethanol

38, 40, 41, 42, 43

Homovanilic Acid

50

Ethiazide23, 31

Hydrocortisone

46

Ethopabate

60

Hydrocortisone Acetate

46

Ethosuximide

54, 59Hydroquinone

56, 61Ethyl Paraben

53

m-Hydroxybenzoic Acid37, 46Ethylene Glycol

38, 41

p-Hydroxybenzoic Acid37, 46o-Hydroxybenzoic Acid

37

H

F
Flavanone

24, 31, 35

5-Hydroxyindole-3-acetic Acid

50

Flurbiprofen

16

5-Hydroxytryptamine

50

Folic Acid46, 52

Hydroxyzine

19

Formaldehyde

38, 62

Hyoscyamine

57, 61

Formic Acid

37

Hypoxanthine52, 58Fructose

40, 41, 42, 43

Fumaric Acid37, 39Ibuprofen

16, 27

Furazolidone

47, 48Inosine50, 52, 58

Inosine 5’-Monophosphate

52, 58I

G
Galactose

40, 41, 42, 43

Inositol

41, 42, 44

Gallic Acid37, 56, 61

Iprodione

55

Glucose39, 40, 41, 42

Isobutyl Paraben

53

Glucuronic Acid38, 44Isoleucine

51

Glucuronolactone

44

Isopropyl Alcohol

38

Glutamic Acid

51

Isopropyl Paraben

53

Ｌ-Glutamic Acid Monosodium Salt

44

Isoproterenol

50

Glutaric Acid

39

Isosine58

Glutethimide

21

Glycerol40, 412-Ketoglutaric Acid

39

Glycine51

Ketoprofen

16

Glycochenodeoxycholic Acid

51

Glycocholic Acid

51

Lactic Acid37, 38, 39

Glycolic Acid37, 39Lactose40, 41, 42, 43

Glycopyrronium Bromaide

21

Lauryl Gallate

53

Glycyrrhetic Acid

56

Leucine

51

K

L

64

INDEXO

L
Levulinic Acid

37

Oxprenolol

13

Lysine51

Oxytetracycline

47, 48P

M
Maleic Acid

39

Paeoniflorin

56

Malic Acid37, 38, 53, 59

Pantothenic Acid52, 58

Malonic Acid37, 39, 53, 59

Phenobarbital

54, 59

Maltose41, 42, 43

Phenol46, 48, 54

Maltotriose

41, 42, 43

Phenoxyacetic Acid

37

Mannitol

40, 41

Phenylalanine

51

Mannose41

α-Phenylethyl Alcohol

35

Meclizine20

α-Phenylethylamine

35, 36

Mepenzolate Bromaide

21

Phenytoin

54, 59Mephobarbital

18, 28o-Phthalic Acid

37

Methacrylic Acid37, 39Pindolol

14, 33

Methanol

38

Pivalic Acid

37

Methionine

51

Potassium Guaiacol-4-sulfonate

54

o-Methyl Hippuric Acid

51

Pranoprofen

16, 27

p-Methyl Hippuric Acid

51

Predonisone

46

m-Methyl Hippuric Acid

51

Prenylamine

14

Methyl Paraben

53

Primidone

54, 59Methyl Salicylate

54

Profenamine

15

Methylephedrine Hydrochloride

54

Proglumide

23

Methylphenidate

20, 29Proline51(1S,2R)-1-Methyl-cis-1,2,3,6tetrahydrophthalate

Promethazine

18

24

Propionic Acid37, 39, 53, 59

Propranolol

14, 33

Propyl Paraben

53, 56

Prostaglandin

53

PTH-Valine

31

Pyridine

46, 48Pyridoxal

52

Pyridoxamine

52

Pyridoxine

52, 58Pyridoxine Hydrochloride

46

Pyroglutamic Acid37, 38N
Naphthalen

48

Nicarbazin

60

Nicotinamide

52, 58

Nicotinamide Adenine Dinucleotide Oxidized

50

Nicotinamide Adenine Dinucleotide Reduced50

Nicotinic Acid46, 52, 58

Nicotinic Acid Amide

46

Nordihydroguaiaretic Acid

53

Norepinephrine

50

Normetanephrine

50

Noscapine

54

R

O
Octyl Gallate

53

Oligosaccharide

43

Oxine-copper

55

Oxolinic Acid47, 48Raffinose40, 41, 43

Riboflavin46, 52, 54, 58

Riboflavin Phosphate46, 52, 58

S
Saccharin

65

53, 59INDEXS

V

Salicylic Acid46, 54

Valine51

Scopolamine

57

Vanilic Acid

37

Scopolamine

61

Verapamil

15

Serine51

Vitamin A

52

Sorbic Acid37, 53, 59

Vitamin A Acetate

45

Sorbitol

40, 41

Vitamin A Palmitate

45

Stachyose43

Vitamin D2

52

trans-Stilbene Oxide

36

Vitamin D3

52

Strychnine

57

Vitamin E

45, 52

Succinic Acid37, 38, 39, 53, 59

Vitamin K1

45

Sucrose40, 41, 42, 43

Vitamin K2

45

Sulfadimethoxine

47, 48Sulfadimidine

47, 48Sulfadimidine

47, 48Sulfamerazine

47, 48Sulfamonomethoxine

47, 48Sulfaquinoxaline

47, 48W
Warfarin

X
Xylitol

40, 41Xylose41, 42Z

T

Zaltoprofen

Tartaric Acid37, 38, 39, 53, 59

Taurochenodeoxycholic Acid

51

Taurocholic Acid

51

Taurodeoxycholic Acid

51

Terbutaline

25, 29

Thiamine

46, 52, 54, 58

Thiamphenicol

47, 48Thioridazine

30

Thiuram55

Threonine51

Thymidine

50

Thymine50

Thymol50

Thyroxine

25

Tocopherol Acetate

52

Tolperisone

20, 29Trihexyphenidyl

15Trimipramine Maleate

20, 29Tyrosine

51

U
Uracil50

Uridine50, 58

Uridine 5’-Monophosphate

50, 5823, 2766

17

Shinwa Chemical Industries Ltd. reserves the right to change product specifications, designs
or prices without notice and without liability for such changes.

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