Livingbiologics.

Biologics workflow solutions

Biologics research solutions• Introduction• Biomolecular discovery• Characterization• Immune function• Manufacturing• Safety and efficacy• Informatics

Technology• Genomics solutions• Detection solutions• Cellular imaging solutions• In vivo imaging solutions• Cell engineering andscreening solutions• Biotherapeutic
production solutions

Big molecules.
Biggerbreakthroughs.
The powerful role of precision biologics as part of therapeuticstrategies – monoclonal antibodies, bispecific and multispecificantibodies, recombinant proteins, vaccines, and targeted nextgeneration cell and gene therapies – becomes increasingly
apparent every day. Unlike traditional chemically synthesized
drugs, which act on a hydrophobic pocket of a protein to activate
or inhibit a kinase pathway, biotherapeutics pharmacologicalaction is by way of binding to its target or immunomodulation.
Harnessing large molecules to create safe and effective therapies
is a complex and expensive undertaking. So we help scientists
like you develop and streamline your entire biologics workflow,
helping you overcome the challenges to bringing consistent, highquality, biological medicines to market – faster than ever before.

• Contact us2 |Biologics research solutions• Introduction• Biomolecular discovery

Discovery,right on target• Characterization• Immune function• Manufacturing• Safety and efficacy• Informatics

Technology• Genomics solutions

Our biomolecular drug discovery solutions will help you takethe disease and target biology from early research to testing
through target model systems.
Collect evidence that supports the target rationale andmechanism of action with automated workflows. Theseworkflows simplify complex analysis, saving time and enabling
focus on the discovery and early characterization of new
biological entities.

Target identification
Early stages of biomolecular discovery consist of target identification andvalidation. Molecular characterization and cellular and in vivo imaging
technologies, physiologically relevant and predictive model systems, and data
analytics software enable identification and validation of disease targets.
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Clone selection and development
We offer multiple chemistries for high-throughput antigen-protein elucidation
that, when coupled with our integrated automation solutions, move you
quickly through your lead discovery workflows.

• Cellular imaging solutions

Accelerate your biomolecular discovery by using a combinationof in vitro and in vivo techniques coupled with software thattransforms data into insights.

• In vivo imaging solutions• Cellular imaging for in vitro target testing

Lead discovery and screening• Cell engineering andscreening solutions• In vivo imaging for target discovery and testingLabs that efficiently and accurately identify key drug discovery parameters
can quickly promote the most appropriate targets and develop medicines
to affect them. Our screening and lead-discovery solutions let you manage
screening data from raw imports, QC, analytics, and visualizations – andpublish and share that data, too.

• Detection solutions• Biotherapeutic
production solutions• Highly interactive visualization for rapid identification andisolation of biologics

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3 |Biologics research solutions• Introduction• Biomolecular discovery• Characterization• Immune function

Know yourbiologics insideand out• Manufacturing• Safety and efficacy• Informatics

Technology• Genomics solutions• Detection solutions• Cellular imaging solutions• In vivo imaging solutions• Cell engineering andscreening solutions• Biotherapeutic
production solutions• Contact usCharacterization and monitoring of a biologics structure,
specific activity, and maintenance of potency is criticalduring the drug discovery workflow to help minimize
development risks.
Our bioanalytical solutions, which cover a wide spectrum
of applications used during drug discovery anddevelopment, help mitigate risks during late stages ofpreclinical development. Let us help you with your protein
biologic, viral or nucleic acid vector characterization andget you closer to clinical trials.

Identity testing
Identification of a biological product during late drug discovery is an important
step in establishing the specific type of molecule being developed and launched
as a therapeutic – monoclonal antibody, bispecific or mutlispecific antibody,
recombinant protein, nucleic acid or viral vector, and so on. Various techniques
can be used to confirm the identity of a biological product.
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Potency testing
Bioassays, including cell-based assays, help determine the potency of thedrug substance, as well as evaluating the reproducibility and stability of thedrug product. Most regulatory agencies require potency studies before therelease of any biologic compound under GMP guidelines.
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Purity and impurity profile
Whether they occur during drug formulation or as APIs age, impurities canaffect the safety and efficacy of biologics, even in small amounts. We offer
innovative solutions for detection of all types and amounts of impurities,
helping streamline your impurity profile workflows while maintaining GMP
compliance in both late drug discovery and later drug development stages.
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4 |Biologics research solutions• Introduction• Biomolecular discovery• Characterization• Immune function

Leveraging thebody’s immune
responses

In vitro assays
We offer a range of highly sensitive immunoassays such as TRF-based assay
technology, and next-gen no-wash assays, for characterizing the cytokine
response, measuring signaling events, and understanding the antibodydependent cellular cytotoxicity (ADCC) of biologics.

Read more• Manufacturing• Safety and efficacy• Informatics

Technology• Genomics solutions• Detection solutions• Cellular imaging solutions• In vivo imaging solutions• Cell engineering andscreening solutions

An immune response to a biological entity is highly dynamic,
involving multiple processes and components. With our assay
platforms you can unravel the interactions between innate
and adaptive immunity. This understanding is key in thedevelopment of effective and predictive treatments.
Leveraging our advanced technology in immune functional
assays, you can gain the scale necessary to support discovery
research when characterizing these responses.

Cellular imaging & analysis
Providing a portfolio of cellular Imaging products to help you answer
complex biological questions, including high-content and live-cell imaging
instruments, image analysis software, cell counters, fluorescent probes,
microplates, and automation.
Read more• Assess cytotoxicity• Identify cytokine release and cell signaling• Evaluate cellular responses• Biotherapeutic
production solutions• Contact us

5 |Biologics research solutions• Introduction• Biomolecular discovery

Biomanufacturing
better health• Characterization• Immune function• Manufacturing• Safety and efficacy

The complex and costly process of biomanufacturing isa key difference between small- and large-molecule drug
development.

• Informatics

Our solutions focus on supporting efficient and compliant
biomanufacturing workflows.

TechnologyWe’ll provide various characterization technologies andrepurposed tools to help you evaluate your vaccines andtherapeutics throughout the process. These resources
can aid in informed decision-making and risk mitigation
promoting adherence to regulatory standards• Genomics solutions• Detection solutions• Cellular imaging solutions

QA/QC - lot release
Throughout biomanufacturing, the controlling and assuring of productquality is a key part of complying with regulatory mandates. To aid this we
provide solutions including bioanalytical assays, multimode plate readersand protein characterization systems.
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Drug repurposing
Huge amounts of archived research and data can be quickly retrieved
and reanalyzed using informatics solutions. When used in conjunction
with validated technology solutions, informatics technology can help you
streamline workflows to enable repurposing of drugs from late-stage
preclinical phases and clinical trials.

Read more• In vivo imaging solutions• Cell engineering andscreening solutions• Biotherapeutic
production solutions• Contact us6 |Biologics research solutions• Introduction• Biomolecular discovery

Safety first,last, always• Characterization• Immune function• Manufacturing• Safety and efficacy• Informatics

Technology• Genomics solutions• Detection solutions• Cellular imaging solutions

During the development of biological products,
comprehensive studies are conducted throughout
various stages to evaluate any potential risks andassess their effectiveness.
Preclinical development plays an importantrole in identifying potential side effects, such as
immunotoxicity, that large molecule candidates may
pose on the immune system. Additionally, strict
regulations are also in place to minimize risks, prioritize
safety, and enable the responsible development andapproval of biological products.

Immunogenicity And Pharmacokinetic/Pharmacodynamic (PK/PD) modeling
The immunogenic potential of biotherapeutic drug molecules can have aneffect at any point, from the drug’s administration to its metabolism andelimination. So it’s important to understand the impact of immunogenicity on
the PK/PD properties of a large-molecule drug.
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Clinical trials
Our informatics solutions for clinical development are designed to streamline
clinical trial data visualization and analysis with real-time access to data in allphases of the discovery-to-commercialization process.
Read more• In vivo imaging solutions• Cell engineering andscreening solutions• Biotherapeutic
production solutions• Contact us

7 |Biologics research solutions

Smarter questions, better answers• Introduction• Biomolecular discovery• Characterization• Immune function

With all the advances in biologics discovery, we’re generating vast amounts of genome and proteome sequencing data. Making sense of allthat data is perhaps the challenge of our time. So our Revvity Signals informatics solution are designed to speed identification of therapeuticcandidates; help you import, align, and analyze biological sequences; and manage experimental, instrument, and outsourced pharmacology data.

• Manufacturing• Safety and efficacy• Informatics

Technology• Genomics solutions• Detection solutions• Cellular imaging solutions

Signals notebook

Lead discovery

Data visualization

Clinical analytics

We offer ELNs to meetthe needs of scientists
and researchers in a wide
range of industries, helping
you organize and shareexperimental data efficiently
and communicate seamlessly
with the common instruments
and devices you use.

Our lead-discovery solutions
provide a faster way tohelp chemists and biologists
gain insights into chemical
structure and biologics
sequence activity through a
guided search and analysis
workflow that queries andrepresents data in intuitive,
intelligent ways.

Our data visualization
platform can empower
your team or your entire
organization to easily minescientific and business dataand gain insights, in realtime. You can create simple
dashboard metrics, predictive
applications, or dynamic realtime analytics applications
with capabilities such as visual
analytics, data wrangling,predictive analytics, location
analytics, and streaming
analytics.

Our solutions streamline
clinical trials with realtime access to data during
all phases of clinicaldevelopment, allowing you tointeract with information assoon as it’s collected. You’rebetter able to explore key
aspects of the protocol for
specified follow-up, ensure
adherence by identifying
drop-outs and violations,facilitate data cleaning anddata quality, and much more.

• In vivo imaging solutions• Cell engineering andscreening solutions• Biotherapeuticproduction solutions
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8 |Biologics research solutions

Genomics: Automation improves workflow efficiency
Our optimized, automated instruments and kits help you meet the challenges of genomics analysis by providing complete, single-source solutions, from sample to results.

• Introduction• Biomolecular discovery

High-throughput
nucleic acid isolation

Nucleic acid & protein analysis

Automated liquid handling

NGS library prep kits

• Characterization• Immune function• Manufacturing• Safety and efficacy• Informatics

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Technology• Genomics solutions• Detection solutions

Detection: Innovative, integrated solutions that accelerate your workflow• Cellular imaging solutions

Whether you’re assessing the early stages of the drug candidate or monitoring an immune response, our assay platforms including immunoassay reagents provide simple, sensitive,
streamlined workflows to accelerate your biologics research and therapeutic development.

• In vivo imaging solutions• Cell engineering andscreening solutions

Radiochemicals andradiometric detectors

Multimode plate readers

Microplates

Immunoassays• Biotherapeuticproduction solutions• Contact us

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Biologics research solutions

Cellular imaging: Phenotype cellular responses to biologics
Our powerful tools can help you gain a more complete understanding of cell biology – and deliver greater insights.

• Introduction• Biomolecular discovery

Automated cell counting &image cytometryHigh-content imaging

Image analysis & data sharing

Microplates for cell imaging• Characterization• Immune function• Manufacturing• Safety and efficacy• Informatics

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Learn moreTechnology• Genomics solutions• Detection solutions

In vivo imaging: The power of preclinical imaging for biologics development• Cellular imaging solutions

Whether you’re monitoring tumor growth and progression, angiogenesis, or metastases, performing toxicology studies, or enhancing your understanding of biological pathways, oursmall-animal imaging tools can streamline your drug development workflows.

• In vivo imaging solutions• Cell engineering andscreening solutions

Optical imaging

Micro-CT imaging

In vivo imaging reagents• Biotherapeutic
production solutions• Contact us

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Biologics research solutions

Cell engineering and screening services
Our comprehensive suite of service solutions can help you drive efficiency and accelerate workflow productivity throughout your organization.

• Introduction• Biomolecular discovery

Cell line engineering

Cell panel screening

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Functional genomic screening

Immune cell screening• Characterization• Immune function• Manufacturing• Safety and efficacy• Informatics
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Learn moreTechnology• Genomics solutions• Detection solutions• Cellular imaging solutions

Biotherapeutic production
Streamline your cell line development process, improve productivity, and accelerate your biotherapeutic programs• In vivo imaging solutions• Cell engineering andscreening solutions

CHOSOURCE™ expression platform

CHOSOURCE™ ADCC+ cell line

CHOSOURCE™ TnT transposontechnology

Bioproduction cell line
engineering services• Biotherapeutic
production solutions• Contact us

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www.revvity.com

For more information on our biologics research solutions visit
www.revvity.com/gb-en/category/biologics

Revvity, Inc.
940 Winter StreetWaltham, MA 02451 USA
www.revvity.com

For a complete listing of our global offices, visit www.revvity.com
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