RELY ON EXCELLENCE

Industrial sealing expertisefor pharmaceutical applications

EagleBurgmann – at the leading edgeof industrial sealing technology
Our products are used wherever safety and reliability count: in the industries of oil & gas, refineries,
petrochemicals, chemicals, pharmaceuticals, food, energy, water, mining, paper, aviation and aerospaceand many more. Over 5,600 employees contribute their ideas, solutions and dedication every day toensure that customers around the globe can rely on our seals. With our modular TotalSealCare Service,
we emphasize our strong customer orientation and offer custom-tailored services for every need.

Unique. Flexible. Always there for you.

Wherever you need us

eagleburgmann.com
info@eagleburgmann.com

10.19 | © 2019 EagleBurgmann Germany GmbH & Co. KG All rights reserved.

Europe • Austria • Belarus • Belgium • Bosnia-Herzegovina • Bulgaria • Cyprus • Czech Republic •Denmark • Estonia • Finland • France • Germany • Great Britain • Greece • Hungary • Ireland • Italy • Latvia •Lithuania • Netherlands • Norway • Poland • Portugal • Romania • Russia • Serbia • Slovak Republic •Slovenia • Spain • Sweden • Switzerland • Turkey • Middle East • Bahrain • Israel • Jordan • Kuwait •Lebanon • Oman • Qatar • Saudi Arabia • United Arab Emirates • Yemen • Africa • Angola • Botswana •Cameroon • Egypt • Gabon • Ghana • Kenya • Madagascar • Malawi • Mauritius • Mozambique • Namibia •Nigeria • South Africa • Sudan • Tunisia • Uganda • Zambia • Zimbabwe• Americas • Argentina • Brazil •Canada • Chile • Colombia • Ecuador • Mexico • Paraguay • Uruguay • United States • Venezuela •Asia-Pacific • Australia • Azerbaijan • Bangladesh • China • India • Indonesia • Japan • Kazakhstan •Korea • Malaysia • New Zealand • Pakistan • Philippines • Singapore • Sri Lanka • Taiwan • Thailand •Vietnam • www.eagleburgmann.com/en/international

30 years of pharmaceuticalsealing expertise
To be successful, pharmaceutical production processes must be highly efficient and flexible
at the same time. Both original manufacturers and toll manufacturers face extreme competition around the world. Yet they can never cut corners to reduce costs, as they must satisfy
the strictest quality and safety requirements. The key to sustained success lies in the optimalcooperation of product and technology specialists. This cooperation makes it possible to create innovative solutions that enable shorter time-to-market cycles, continuous performance
improvements and cost reductions. In-depth knowledge of sealing technology helps makethese improvements reality.
EagleBurgmann makes it all possible, with local sealing technology experts around the world.

Quality is our promise
Hands-on consulting and engineering

Driving innovation in seals

EagleBurgmann reliably delivers safe sealsolutions. You start benefiting from oursupport and extensive expertise long before
a seal is provided. Mastering the issues
involved with “good manufacturing practice”
is also part of our daily business. And ourfield service ranges from on-site commissioning to repair.

Extensive knowledge of sealing technology,
machines, materials and media, as well as
industrial processes, is the basis for impressive design solutions. We back up this promise to our customers with our own research
centers in Germany and Japan, along witha global network of testing institutes andpartnerships with universities, customers
and suppliers.

From standard to extraordinary
From our standardized, modular productrange to complex, customer-specificdesigns, we offer outstanding sealing
technology with a unique range of options.
We are sure to meet your needs, too.

Conserving resources
Sustainability management is always partof our work. To protect the environment,
EagleBurgmann goes beyond the legal
minimum whenever possible. We always
strive to minimize the impact of our production processes. At the same time, weimprove the environmental handprint of ourcustomers with our innovative products.

2Always close, always fast
With over 60 subsidiaries and 250 locations,
EagleBurgmann is at home in all major world
markets. Thanks to our production networkwith plants in Europe, Asia and North andSouth America, we can supply you reliably
at any time. And with our dense network ofsales and service centers, we are definitely
in your area.

„Day in, day out, our business consists ofunder­standing the needs of our customers,
answering their challenging technical questions
and actively assisting them with implementation
in a heavily regulated environment.
Thomas Boehm, Head of Engineering Processes & Support, EagleBurgmann

Technical and organizational
conditions
The rules of “good manufacturing practice “(GMP) lay out principles and guidelines
for the manufacture of pharmaceuticalproducts. However, they are not a fixed
construct. Even the qualified and validated status allows for improvements inprocess and technology. EagleBurgmann
has the know-how to directly support
companies with continuous improvement. We work beside our customers
on the design of solutions within theexisting GMP framework, support themin tests and help create the necessary
documentation of the change control
process. Processes and components canbe continuously optimized in line with therequirements in this way.

Good engineering practice
The foundation of GMP-compliant
reliability is laid during the engineering
stage at EagleBurgmann. We rely on
proven methods and processes in accordance with “good engineering practice”(GEP). This means that we guarantee not
only technically reliable seal solutions,but also the efficient and well-documented production of products, whichsimplifies the subsequent qualificationsand validation.

Our hygiene classes for seals
Our hygiene classes for seals are uniqueon the market. They are derived from therespective hygiene risk of the product,
as well as the existing risk minimization
measures, and determine the scope ofhygienic design – entirely adapted to thespecific application.

„Multiple sealing options for every needFor every seal solution, we carry out a detailed assessmentof the processes and technology: from product properties andmachine requirements to cleaning and maintenance concepts.
In this way, we ensure that our solution lives up to its promiseand fits seamlessly into the required standards.

Industrial production systems simply cannot function without seals. The number of seal
points and the variety of media handled is extensive. So many plant components need to besealed: agitators, pumps, special machines, valves and flanges, as well as pipes and ducts.
The reliability of the entire plant depends on the quality of many individual parts, such as
seals. Seals should therefore be understood as extremely important key components. They
protect the technical system and environment from contamination and help prevent emissions.
The selection of the right seal, its design, the material used and the way in which it is operateddepends on many different factors: the substances to be processed, the operating conditions, the machine, the process flows and special aspects of the process. We know how thesefactors impact functionality, efficiency and reliability, and we employ our expertise to create
reliable technical solutions.

Kerstin Birner, Product Management, EagleBurgmann

Requirements and influences on seal technology

Media properties∙ Aggregate condition∙ Viscosity∙ Aggressiveness with respect
to materials

Design criteria formechanical seals withhigh hygiene class● Homogeneous surfaces● Avoidance of gaps and deadspaces● Rounding of corners and edges● Roughness value for surfaces
with product contact Ra ≤ 0.8 μm● Suitability for cleaning via CIP/SIP● Resistance to product and cleaning
media by surfaces with productcontact● All materials that come into contact
with products must pose no safetyconcerns in compliance with statutory requirements and applicableguidelines● Threading in contact with productmust be avoided or properly sealed
to ensure a sterile environment● Sealing on the product side using
O-rings in special grooves orgap-free special profile rings● Self-emptying● Suitable supply media

Process flows andoperating conditions∙ Batch operation /continuous operation∙ Mixing∙ Reacting∙ Fermenting∙ Pumping∙ Filtering∙ Centrifuging∙ Drying

Machine technology∙ Top, bottom, side entry drives∙ Placement of the bearing,shaft deflection
Explosion
protection (ATEX)∙Measurement
and∙monitoring equipment∙ Maintenance intervals
and concepts∙∙

Cleaning process and media

CIP – Cleaning in PlaceSIP – Sterilization in Place

5

Industrial sealing options at a glance

DiamondFace: Innovative sliding surface technology
for maximum operational performance of agitator and pump seals

Whatever the requirements, we can supply the right seal system thanks
to the unique scope of our production portfolio. We deliver custom-tailored
seal solutions according to your specific requirements with the help ofstandardized assemblies, components and functional extensions. For ourcustomers, this means reliable technology, fast delivery times and maximum
efficiency.

Dry-running agitator seals• Standard and hygienic design• Steel and enameled containers• Single and double seals,
with/without bearing• Series-manufactured seals
or special designsMagnetic couplings• Standard and hygienic design• Hermetically sealed• Top and bottom entry drives
6Quench systems• Standard and hygienic design• Unpressurized supply of quench fluid• For single and multiple seals

DiamondFace is an innovative microcrystalline diamond technology for mechanical seals.
It is characterized by extreme hardness, high wear resistance, excellent thermal conductivity,
maximum chemical resistance and low friction coefficients. The coating adhesion also exceeds
all known practical requirements. For example, this makes partial dry running possible while
increasing the lifespan of mechanical seals by many times, prolonging the maintenance intervals
and significantly reducing the life cycle costs.

Fluid-lubricated agitator seals• Standard and hygienic design• Steel and enameled containers• Single and double seals,
with/without bearing• Series-manufactured seals

Gas-lubricated agitator seals• Standard and hygienic design• Steel and enameled containers• Double seals, with/without bearing• Series-manufactured seals
or special designs

SeccoLip lip seals

Mechanical seals for pumps

Gaskets and compression packings

Expansion joints• Dry-running lip seal for agitators• Steel and enameled containers• Modular design• Rolling bearing optional• Standard and hygienic design• Series-manufactured seals andspecial designs• Single and multiple seals

or special designs

Thermosiphon and buffer/barrier
fluid systems• Standard and hygienic design• Pressurized supply of barrier medium• For double seals

Gas supply system• Standard and hygienic design• For double seals• For dry-running and gas-lubricated seals• Standard and hygienic design• Standard and hygienic design7

360° sealing expertiseEagleBurgmann offers more than technology. No matter what the question,
we stand behind our customers in all their needs relating to the operation of theirseals. From application consulting, testing and simulation to documentation,
training, service and support - our consulting, engineering and customer services
help increase system availability, make production processes more flexible andlower costs.

Application consulting

Qualified offer creation

Design adaptation
Basic research
Research & development

cessdpecing

al m chineastors •Standardizedmodels∙Research collaboration
Simulation & calculations
ExpressCenter

Engineeredsolutions

Acceptance testing & analysis
EagleBurgmann Academy

acCleani

reprProductocess

Pro d u ctio

minp ros∙

ersxe

∙c

Application technology &product designry∙ s

Whether for laboratory use, batch processesor series-scale production, every single project
benefits from our expertise and extensive
practical experience in the pharmaceuticalindustry thanks to consistent knowledge
management.

s• pumps„r

Test & experimental setups

e ntrifu g eApprovals & certifications

Services

Installation & commissioning
Documentation
Replacement parts &warehouse management
24/7 repair
Predictive maintenanceTraining
Standardization

Uwe Scherf, International Sales, EagleBurgmann

Service programs
Field service

Reliability engineering

Service agreements

9Proven successaround the world

Value-addingand dependable

Avoidance of product contamination

Close proximity ensures faster responses.
And time is not a factor to be underestimated.
No one can afford long downtimes for service
work. Ballooning costs must also be avoided.
With over 250 locations and more than 120
service centers, EagleBurgmann is locatedaround the globe and always near you. 365
days a year, 7 days a week and 24 hours a day.
Wherever and whenever you need us, we arethere.

thanks to the barrier medium: Conversion of paddle-throughdryers to the dry-running seal SeccoMix R. Drug substanceproduction, Great Britain.

Hermetically sealed
and low-maintenance in operation: SMAK magnetic coupling
for agitator tank with bottom entry drive. Drug substanceproduction, France.

Compensation of shaft deflection
with the engineered solution MR5S2T. Conical dryer for
powdered drug substances, Switzerland.

1

Significantly extended MTBF
despite inadequate lubrication and partial dry running:
Conversion of fermenters to robust MR-D with DiamondFace
technology. Production of biocultures, Singapore.

High service-friendlinessby using the fully partitioned agitator seal TMS.
Production of preliminary products for cosmetics, France.

Retrofits● Modification● Standardization concepts

2

Mobile agitator tankwithout a buffer/barrier fluid system thanks to the use ofdry-running SeccoMix seals. Production of preliminary
products for bio-pharmaceuticals, Belgium.

Bad actor elimination
thanks to DiamondFace technology for Cartex pump seals
with alternating operating conditions and dry runningphases. Antibiotic production, Great Britain.

Repairs● Wearing part reconditioning● Fast-Lane and ExpressCenter

3

Seal for enameled container
Successful operation of the M461 with buffer/barrier fluid
system in a stirring reactor with top entry drive. Productionof pharmaceutical intermediate products, Germany.

Maximum pressure
Customer-specific design of the seal HSMR35 for paddle-­
through dryers for production under an explosive atmosphere. Production of silicic acid products, Germany.

Bad actor solutions● Failure and damage analyses● Diagnosis and support● Test runs

4Service agreements● Repair class, fixed fee and primarysource programs, individual serviceagreements

10We‘re closer than you think. Our experts are always nearby
and happy to offer their sealing expertise. Get in touch:

pharma@eagleburgmann.com

RELY ON EXCELLENCE

Industrial sealing expertisefor pharmaceutical applications

EagleBurgmann – at the leading edgeof industrial sealing technology
Our products are used wherever safety and reliability count: in the industries of oil & gas, refineries,
petrochemicals, chemicals, pharmaceuticals, food, energy, water, mining, paper, aviation and aerospaceand many more. Over 5,600 employees contribute their ideas, solutions and dedication every day toensure that customers around the globe can rely on our seals. With our modular TotalSealCare Service,
we emphasize our strong customer orientation and offer custom-tailored services for every need.

Unique. Flexible. Always there for you.

Wherever you need us

eagleburgmann.com
info@eagleburgmann.com

10.19 | © 2019 EagleBurgmann Germany GmbH & Co. KG All rights reserved.

Europe • Austria • Belarus • Belgium • Bosnia-Herzegovina • Bulgaria • Cyprus • Czech Republic •Denmark • Estonia • Finland • France • Germany • Great Britain • Greece • Hungary • Ireland • Italy • Latvia •Lithuania • Netherlands • Norway • Poland • Portugal • Romania • Russia • Serbia • Slovak Republic •Slovenia • Spain • Sweden • Switzerland • Turkey • Middle East • Bahrain • Israel • Jordan • Kuwait •Lebanon • Oman • Qatar • Saudi Arabia • United Arab Emirates • Yemen • Africa • Angola • Botswana •Cameroon • Egypt • Gabon • Ghana • Kenya • Madagascar • Malawi • Mauritius • Mozambique • Namibia •Nigeria • South Africa • Sudan • Tunisia • Uganda • Zambia • Zimbabwe• Americas • Argentina • Brazil •Canada • Chile • Colombia • Ecuador • Mexico • Paraguay • Uruguay • United States • Venezuela •Asia-Pacific • Australia • Azerbaijan • Bangladesh • China • India • Indonesia • Japan • Kazakhstan •Korea • Malaysia • New Zealand • Pakistan • Philippines • Singapore • Sri Lanka • Taiwan • Thailand •Vietnam • www.eagleburgmann.com/en/international