Contents

Introduction

The 21st century has been referred to as the era of the environment, nanotechnology, biology,
Introduction

and information. With its origins in the natural sciences, chemistry was concerned primarily withThe Principle of Education in the Department of Chemistry ……

1

the study of the structure, properties, and reactions of materials. These discoveries led to the………………………

1

creation of new materials, and this in turn has become increasingly important for solving various

Organization of the Department of Chemistry …………………

2

problems of this century. The laboratories in the Department of Chemistry, Division of Material…………………………………

3

Science, Graduate School of Science, at Nagoya University are conducting research programs

Professor Noyori Wins the Nobel Prize in Chemistry 2001 ……

3

based on a traditional academic approach to the study of chemistry such as organic chemistry,

Entrance Examination for the Graduate Course ………………

4

biochemistry, inorganic chemistry, and physical chemistry.

Global COE Program……………………………………………

5

The research outputs of the laboratories in the Department of Chemistry include the development

University Life of Graduate Students and Their Academic Program…

7of asymmetric synthesis, research of carbon nanotubes and similar work that has been well received

Research Center for Materials Science …………………………

8

worldwide. Consequently, we have cultivated researchers and educators who are active

Laboratory of Organic Chemistry I………………………………

9

internationally through the establishment of collaborative efforts in all of the scientific fields,

Laboratory of Organic Chemistry II …………………………… 11

including engineering, agriculture, pharmacology, and medicine. As you well know, the first Nobel

Laboratory of Biochemistry …………………………………… 13

Prize in chemistry in this century was conferred upon Professor Noyori who has led the field of

Noyori Laboratory ……………………………………………… 15

organic chemical reactions for a long time. This represents the high and international level ofLaboratory of Nano-Structured Materials ……………………… 17

research conducted in our laboratories. Furthermore, our department has been selected to be part ofLaboratory of Photo-Physical Chemistry ……………………… 19

the Global COE Program in Chemistry that started in 2007. This is yet another telling indicator ofLaboratory of Advanced Materials ……………………………… 21

how high the quality of our research is. You will find details of these and other aspects of ourLaboratory of Analytical Chemistry …………………………… 23

Department in the pages that follow.

History of the Department of Chemistry

Construction of Laboratories…………………………… 25

This pamphlet has been compiled for prospective students who want to conduct research andLaboratory of Bioinorganic Chemistry ………………………… 27

study in the laboratories of the Department of Chemistry at Nagoya University. If you are

Organic Synthesis Group ……………………………………… 29

interested in joining one of our laboratories, please contact the Chief of Department, the Chemistry

Laboratory of Theoretical Chemistry …………………………… 31

Department Office, or the laboratories directly for more information, all of which is also available

Quantum Chemistry Group …………………………………… 32

on the internet (http://www.chem.nagoya-u.ac.jp/). Telephone numbers and e-mail addresses for

Physical Inorganic Chemistry Sub-group ……………………… 34

each laboratory are listed at the end of this pamphlet.

Laboratory of Inorganic Chemistry

Global COE Office ……………………………………………… 35
Glass Shop …………………………………………………… 36
List of the Faculty Members …………………………………… 37
Campus Map………………………………………………… 38
2010
Kentaro Tanaka
Chair of Department of Chemistry
Division of Material Science, Graduate School of Science, Nagoya University

The Principle of Education in the Department of Chemistry
By talking with nature at the level of atoms and molecules, we understand nature.
The origin of chemistry comes from the joy making new materials based on
knowledge. Natural materials have diverse structures and qualities with many usefulphysical and physiological activation properties, which human beings have had thewisdom to exploit since ancient times. The principal focus of traditional chemistry is
elucidating of the structure of various materials, clarifying their reactions, andsynthesizing useful substances that exist in nature. Modern chemistry has advanced
this scope further by creating chemical compounds that have new structures andphysical properties, studying their properties, clarifying the structures and the reaction
mechanisms of organic molecules, and synthesizing physiologically active
substances. Thus, modern chemistry has come to assume the role of being the key
science in the study of materials in the broad academic fields of both materials andlife sciences. Along with developing new materials to create a prosperous andcivilized society, it is also expected that chemistry will play an active role in solving
environmental problems such as global warming and destruction of the ozone layer,
and, thus, that it might have to be applied to ensure the very existence of humanbeings.
The Department of Chemistry intends to cultivate talented people capable of doing
the following: 1) Becoming internationally respected researchers who will lead and beat the forefront of research in chemistry at both public and private research institutes,
and who plan to create new research fields, 2) educators of chemistry who will becapable of transferring both chemical knowledge and associated technology to themany educational institutes of higher learning and that have the creativity to exploit
future opportunities, and 3) advanced professionals who are well versed and highly
specialized in their fields at the forefront chemical technology. We haveinternationally active researchers as faculty members in each of the fundamental
fields of chemistry (organic chemistry, biochemistry, inorganic chemistry, andphysical chemistry), and we foster the most radical environment within which to
conduct research and education.

identified as being the first Education COE to implement a system of praising
graduate students publicly for unrecognized efforts, resulting in outstanding researchachievements. In 2002 we were selected to be part of the 21st Century COE
Establishment Program, and have consequently been able to prepare various forms of
support for our graduate doctoral students. Moreover, these high activities have beensucceeded by the Global COE program which has just launched in 2007. These four
COEs have brought laboratories in the Department of Chemistry dramatically
improved conditions for conducting research and education, and have made it
possible for us to offer the best environment for research and education at home andabroad.

Organization of the Department of Chemistry
There are 11 laboratories in the Department of Chemistry, including: Organic
Chemistry I, Organic Chemistry II, Biochemistry, Nano-Structured Materials, Solid
State Chemistry, Theoretical Chemistry, Advanced Materials, Analytical Chemistry,
Inorganic Chemistry, Bioinorganic Chemistry, and the Noyori Laboratory. The
members of the Research Center for Materials Science belong to any one of these 11
laboratories, or to the Organic Synthesis Group and Physical Inorganic Chemistry
Subgroup, and they serve as the core of the research activities at Department ofChemistry (see figure below). Each laboratory in the Department of Chemistry has an
intimate relationship with the Research Center for Materials Science for both researchand education. In addition, there are Chemistry Department Office, Chemistry
Department Library, and the Glass Shop at the Technical Center that all support thelaboratories and groups.

History of the Department of Chemistry
The history of Department of Chemistry, Division of Material Science, Graduate
School of Science can be traced back to the foundation of Nagoya Imperial University
in 1939, and the establishment of the Department of Chemistry, School of Science, to1942. After shifting from the old to the new education system, new courses weresuccessively established to correspond with the diverse needs of chemistry. The
number of teaching staff was increased, and facilities for research and education were
improved. In the interim, the department was able to send many graduates off toindustry, the public service, and academic circles.
More recent improvements and diversification of the graduate school came into
being in 1996 with the faculty activities in School of Science transferred to the
Graduate School of Science, which had been established as a new department. At thattime, all of the laboratories from the Department of Chemistry, the solid-state physics
and biophysics laboratories of the Department of Physics were amalgamated into theDivision of Material Science that would concern itself the creation of new materials
and potential application of those materials. The faculty members of the Chemistry
Department now belonged to the Graduate School of Science and took charge of
research and the education of graduate students in the Division of Material Science, as
well as the education of undergraduate students.
These activities all happened against the background of the establishment of theCenter of Excellence (COE) Program in 1995. The outstanding results of the COE
program were acknowledged, and the Research Center for Material Science wasestablished in 1998. Moreover, in 2000 the Division of Material Sciences was

12Construction of Laboratories

Entrance Examination for the Graduate Course

Organic Chemistry I
Professor
ITAMI, Kenichiro
Assistant Professor
YAMAGUCHI, Junichiro
Assistant Professor
SEGAWA, Yasutomo

Analytical Chemistry
Professor
TANAKA, Kentaro
Assistant Professor
YAMADA, Yasuyuki
Assistant Professor
KAWANO, Shin-ichiro

Organic Chemistry II
Professor
YAMAGUCHI, Shigehiro
Assistant Professor
FUKAZAWA, Aiko
Assistant Professor
SAITO, Shohei

Inorganic Chemistry
Professor
TATSUMI, Kazuyuki
Associate Professor
OHKI, Yasuhiro
Assistant Professor
MATSUMOTO, Tsuyoshi

Biochemistry
Professor
Associate Professor
Associate Professor

ENDO, Toshiya
YOSHIHISA, Tohru
NISHIKAWA, Shuh-ichi

Noyori Laboratory
Professor
Associate Professor
Assistant Professor
Assistant Professor

Bioinorganic Chemistry
Professor
WATANABE, Yoshihito
Associate Professor
NAKAJIMA, Hiroshi
Assistant Professor
SHOJI, Osami
Assistant Professor
FUKUSHIMA, Takashi

NOYORI, Ryoji
SAITO, Susumu
NAKA, Hiroshi
TANAKA, Shinji

Nano-Structured Materials
Professor
SHINOHARA, Hisanori
Associate Professor
KITAURA, Ryo
Assistant Professor
TOMIYAMA, Tetsuo
Assistant Professor
MIYATA, Yasumitsu
Photo-Physical Chemistry
Professor
HISHIKAWA, Akiyoshi
Associate Professor
OUCHI, Yukio
Theoretical Chemistry
Assistant Professor
MATSUMOTO, Masakazu

Organic Synthesis
Professor

KITAMURA, Masato

Quantum Chemistry
Associate Professor
IRLE, Stephan
Physical Inorganic Chemistry
Associate Professor
TAKAGI, Hideo D.
G-COE Office
Associate Professor
Associate Professor
Glass Shop
Head Technical Staff
Technical Staff
Technical Staff

FISCHER, Berthold
KATO, Kiyonori
NODA, Toshiaki
NATSUME, Hideko
OKAMOTO, Hisakazu

Advanced Materials
Professor
AWAGA, Kunio
Associate Professor
MATSUSHITA, Michio M.
Assistant Professor
YOSHIKAWA, Hirofumi

Professor Noyori Wins the Nobel Prize in Chemistry 2001
In October 2001, the Royal Swedish Academy announced

students from our own department as wellstudents who have different majors or are fromother universities. The administration ofentrance examinations for the graduate school
is only done to assess the general academic
ability of potential applicants. We also permit
applicants from other universities to skip
grades in cases of excellent academic ability.
Furthermore, we examine a variety of subjects
so as to better appraise applications fromapplicants with different majors.
If you are from another university and arethinking of taking the examination, we would
strongly recommend that you contact the
professor of the laboratory you hope to join
and also that you try to consult with him/her inperson whenever possible. A summary of
research interests for each laboratory can befound in this pamphlet, and if you like to havemore information about laboratories, pastexamples of entrance examination questions(except for foreign languages), andinstructions regarding the entrance
examination for our graduate school from ourhomepage (http://www.chem.nagoya-u.ac.jp/).
Please see phone numbers and e-mailaddresses listed at the end of the pamphlet(page 37) to make contact with relevant
laboratories.

the production of medicines, aromatic chemicals, andrelated substances. His

materials in harmony with the global environment.

contribution of thesefundamental principles

that Professor Ryoji Noyori and Dr. William S. Knowles (aof only one of the two forms. Consequently, preferential

Professor Noyori exploited many kinds of asymmetric

former researcher at Monsanto Company, U.S.A.) would be

production of the right or left forms using non-enzymatic

catalyses, especially the asymmetric hydrogenation ofand techniques also led

methods is a major issue for chemistry.

olefins and ketones by chiral homogeneous catalysts. Theseto the industrial produc-

Noyoricatalysts consist of a transition metal and BINAP (or its

tion of more complex

suggested that a novel

derivatives), a chiral diphosphine ligand(s) originallycompounds including

for his work on chirally catalyzed oxidation reactions.

type of ‘organometallic

devised by him and his coworkers. In particular, by

prostaglandins, carba-

Their research made the artificial production ofmolecular catalysis’, one

inventing a catalyst comprising BINAP and ruthenium

penem antibiotics, and‘Enantiomer’ possible; a subject that had comprised a very

that does not rely on(Ru), he markedly expanded the scope of asymmetricquinolone-type anti-bacterial agents. In addition, Professor

important topic of study in the 20th century. Prof. Noyori

naturalishydrogenation to extremely practicable levels.

Noyori’s research has resulted in the large-scale production

representative of the

Furthermore, significant progress was made in theof the aromatic substance (–)-menthol at unprecedented

universal process of‘asymmetric amplification’ phenomena observed during thelevels since 1983, having a marked impact on the industrial‘asymmetric multiplica-

addition of organozinc compounds to aldehydes in theworld.

not identical. These molecules frequently have totallytion.’ His innovative

presence of catalytic chiral amino alcohol. Thereafter, hehydrogenation of carbon dioxide in its super-critical state,

opposing characteristics depending on whether the

research facilitated theelucidated the reaction mechanism underlying such catalytic

as well as environmentally benign oxidation reactions by amolecule is of the right or left hand form. While one handsynthesis of artificiallyprocesses and applied them to the creation of many usefultungsten complex in aqueous hydrogen peroxide. All ofhas the potential for being an excellent medicine, the othercreated right and left handsubstances. In fact, using his own methods, Professor

these impressive contributions keep fueling a worldwide

hand can be a dangerous poison. Traditional organic

formschiralNoyori made numerous successive innovations in the

campaign to promote the development of chemical

synthesis results in the production of a racemate, a 1:1

catalysts

has

synthesis of physiologically active substances such astechnology for environmentally compliant engineering intremendous potential in

terpenes, alkaloids, amino acids, vitamins and nucleic-acid-the 21st century.

awarded the Nobel Prize for Chemistry for their work on
chirally catalyzed hydrogenation reactions and Professor K.
Barry Sharpless (The Scripps Research Institute, U.S.A.)

et al. had realized their dreams.
Enantiomers make a pair of molecules that are mirror
images of each other (left-right hand relationship) but are

mixture of such right hand (good) and left hand (bad)3

substances. However, natural enzymes can make molecules

The Division of Material Science is a new
major that is supported by the laboratories of
the Departments of Chemistry and Physics.
While respecting the traditions of chemistry
and physics, we maintain interchanges in thisdivision with some programs. These programs
include having special talks to discuss
excellent or interesting masters' theses, etc.
There are two routes to enroll for the
master's course in the Department ofChemistry. One is to take the entrance exam
held for senior and graduated students inAugust or September. Another way is to enter
through the educational system in which
students are allowed to skip grades if they
qualify in their third year of undergraduate
school (a total of 10 students have taken
advantage of this system since 1992 when it
started.) In the latter case, prospective
applicants need to apply to be recognized as an"excellent student" in December and areprovisionally accepted until such time as theysuccessfully complete the entrance exam in
February.
The Division of Material Science
encourages, and has a preference for, graduate
students who have studied at different
universities and that have majors in various
fields. We are wide open to prospective

Professor

enzymes,

using
and

His creative efforts have expanded to the4Global COE Program"Establishment of COE for Elucidation and Design ofMaterials and Molecular Functions"Chemistry expands and creates researchareas in collaboration with physics and life
science, continually producing functional
materials which support the development ofmodern society. Today, at the beginning of
the 21st century, this trend is growing
stronger. However, new developments should
be consistent with harmonization of the global
environment and social ethics. It is an urgent
issue to foster the growth of individuals who
can lead such developments in chemistry.
With this situation in mind, world-leading
researchers gathered from the chemistrygroup* and the applied chemistry group** ofNagoya University to establish a global
education and research center in fundamental
chemistry with a focus on molecular materials.
During the period of this Global COE
program, we aim to develop young global
research leaders responsible for the future ofmaterials science through comprehensive andworld-class education and research forcreating new trends in the development ofmolecular functions in materials science.
*Chemistry group: Department of Chemistry,
Graduate School of Science; Research Center
for Materials Science. **Applied Chemistrygroup: Department of Applied Chemistry,
Graduate School of Engineering.

Research Projects – Creation of new trends
in molecular functional materials science:
The main target of this COE is the creationof new functional materials in conjunction
with acquiring a deep understanding of
biological functions. To this end, four researchteams have been organized to pursue thefollowing sub-themes as we develop advanced
research activities that include collaboration
amongst the teams:
1) “Highly Efficient Chemical Synthesis”
which underlies the creation of materials as
the basis of materials science and life
science, reduces environmental load, andprovides the means for efficient syntheses oforganic/inorganic and organometallic
compounds to produce valuable newmaterials.
2) “Use of Polymer Science for Developmentof Molecules with Novel Properties andFunctions” through first-order structure
control and hierarchical self-organization by
rational design of various molecules ranging
from functional molecules to biomolecules,
polymers and organic-inorganic composite
higher-order systems.
3) “Development of Molecules with New
Functions Through Nano-chemistry” on the
nano-scale such as fullerenes, nanocarbons,
thinfilms,
andsupramolecular materials.
4) “Chemical Aspects ofLife Science” for gaining
an understanding of thecomplexity of biologicalphenomena by elucidating
the mechanisms of actionof bioactive natural
products, protein transport
processes, and enzymecatalyzed reactions.

Human resource development andeducation – Producing global leaders inmolecular functional materials science:
Research leaders of the next generation must
acquire advanced expertise and wide-ranging
basic knowledge in related areas. These
individuals should also have a high standard
social conscience as well as the ability toapply their expertise to unexplored fields andinter-disciplinary areas. Thus, we foster thedevelopment of global leaders in molecularfunctional materials science through education
and research while instilling values such as
morality, independence and respect for othercultures. In order to provide a high level ofexpertise and wide vision, we introduced an
integrated and systematic program forgraduate school education across the School of
Science and the School of Engineering. As acomplement to the graduate school lectures,
we hold various seminars to foster
development of broad academic knowledge.
Specifically, in addition to traditional seminars
in each area, we will organize crossdisciplinary seminars attended by coordinators
to cultivate basic knowledge in related areas.
Furthermore, we provide seminars on“Science in Society” and career path education
seminars.
Establishing a hub in the international
research network:
In order to develop comprehensive materials
science, we continuously promote global andinter-disciplinary collaborations, establish an
information network, and increase academic
exchange by holding international conferences
and inviting researchers. We will thus
establish a center serving as a hub for thescientific network to facilitate collaborations
and sharing of information in a safe research
environment in conformity with global
standards.

distinguished overseas researchers on a shortor mid-term basis. We also send doctoral
students to overseas research institutes on a
mid- or long-term basis to expand theirresearch vision and to cultivate their research
frontier spirit.
International conferences - We holdinternational conferences and workshops toexchange latest research information and topromote academic exchange.
Recruiting foreign faculty and postdoctoral
fellows - We recruit foreign faculty andpostdoctoral fellows by international
promotion of research fellow and faculty
positions.
Collaborating with overseas graduate schools- Through the “Japanese-German Graduate
Externship” program with the University of
Münster (Germany), we have implemented the
mid- and long-term mutual exchange ofdoctoral students and young faculty members.
We are also engaged in personnel exchange
and joint research with the University of
Minnesota (US). We will expand this global
academic exchange and collaboration as partof the COE program to the Tata Institute(India), NIST (US), and the University ofGroningen (Netherlands).
Foreign visiting professors - We actively
pursue joint research with long-term visiting
researchers (6–12 months) using the 3
positions of foreign visiting professors at the
Research Center for Materials Science.

Hosting international researchers andsupporting overseas appointments ofdomestic researchers - We invite

56University Life of Graduate Students and Their Academic Program
Master course students belong to one of 14
laboratories and groups and do their research underresearchers, and so on.

the guidance of a professor for their degree along

For financial support to attend school, you canwith taking lectures. There are various classes for

apply for a scholarship from the organizations such

graduate students; some are advanced studies inas the Japan Student Services Organization. For thechemistry and others are interdisciplinary studies,

3 years from 2007 through 2009, 70 out of the 126

which is one of guiding principles of the Graduate

graduate students reading for a master's course that

School of Science. Students are required to earnapplied for the scholarship, 81 students (including

both credits, and also required to get credits of

those who where awarded bursaries while in thecolloquium through seminars at individual

middle of their degree) received financial assistance.

laboratories. It takes approximately 2 years to

All of the 18 doctoral applicants were awarded thecomplete a master's thesis after entering graduate

loan. In addition, there is the Research Fellowshipschool and the master's degree is awarded. There isfor Young Scientists from the Japan Society for the

an award for an "Outstanding masters thesis", aPromotion of Science directed at supporting talented

system to publicly acknowledge the efforts ofdoctoral students. If selected, you will receive a

hardworking students so that graduate students willsalary (¥200,000 per month in 2009) and a research

get more motivated to do their research.

fund (¥1,500,000 or less per year) from the onset of

After getting a master's degree, some students

the doctoral course at the earliest. From 2007

stay to go on to the doctoral course and do morethrough 2009, 14 students were awarded theadvanced research to get a doctor's degree, while

assistance for 3 years.

others get a job in the private sector. In the 3 years

In recent years, graduate students have come tofrom 2007 through 2009, 38 out of 117 graduate

participate actively in the education and research instudents with a master's degree went on to thethe Department of Chemistry as teaching assistants

doctoral course, 68 were employed by private(TA) or research assistants (RA). Being a TA means

enterprise, and 11 went into other lines of work.

that you give assistance in classes and chemical

There are some students who received a master's

experiments, and about 60 students in the master's

degree at other universities and entered the doctoral

degree course are adopted every year. Conversely,

course of Department of Chemistry. In either case, it

RAs take part in on going research projects in eachtakes approximately 3 years to complete a doctoral

laboratory and takes care of necessary equipment

thesis. The degree of Doctor of Science will be

and gives assistance in promoting effective researchawarded if they pass the examination for becoming a

activities. Approximately five doctoral students areprofessional researcher. There are circumstances inawarded these positions every year. This means thatwhich particularly talented students can receive theirgraduate students have great training opportunities

doctoral degree in less than 3 years. After getting

and to become leaders in education and research

the degree, some become researchers at universities

along with getting paid for working as TAs or RAs.

and research institutes, while others are employed by

7

private enterprise or become postdoctoral

Research Center for Materials Science
Research Center for Materials Science: RCMS
was established in April 1998 and was the first coreresearch center in Japan to comprehensively andinternationally promote fundamental research forthe creation of "materials" that have the potential to
improve human society in the future. Aimed at
finding solutions to important problems faced bycontemporary society, such as global environment,
energy, food, and health. We aim to produce
materials that can be used to create a new scientificconcepts and for building a rich society.
Molecules and their assemblies consist of afinite number of different atoms. New materials
with various properties can be obtained bycontrolling the composition, bonding, and spatial
arrangements of the atoms. The core activity of
research dedicated to the creation of materials at
RCMS is to investigate the properties of a large
variety of molecules accurately and closely, to thendesign and synthesize materials with new proprtties
as necessary. To realize these aims, it is important
to elucidate the mechanisms of thechemical phenomena that affectthe target molecules andassemblies at the molecular level
and to find efficient methods forthe conversion of these materials.
Advanced material science is
expectedtoaccelerate
development of the field ofchemistry. In turn, chemistrylearns from, and is compatible
with, nature through the search for physiologically
active natural substances and investigation ofchemical reactions of life phenomena, such as
metal enzyme functions.
From this background, it is apparent that all of
the members of RCMS perform research in organicand inorganic materials synthesis, functional andbiomaterials research, and molecular catalysts. The
research achievements will be integrated into new
basic science for the creation of novel functional
materials that surpass those currently in existence.
Furthermore, these activities will be essential forthe development of many new kinds of basic
science and new technologies, and will be a key
component of the international contributions Japan

will be able to make as a nation of science andtechnology. Research in RCMS is being observedwith keen interest from both within and outside thecountry, and the research achievements are
publicized internationally.
RCMS was combined with Chemical Instrument
Center in April 2004 to become a more integrated
research organization. The amalgamation of
RCMS and Chemical Instrument Center, the latterof which was founded in 1980 as an intrauniversity shared facility, meant that the former
gained access to advanced
measuring instruments andsophisticatedmeasuring
techniques. The research activities
which had been performed in
Chemical Instrument Center arecontinuedinChemicalInstrumentation Facility.
The research structure of
RCMS is organized flexibly togive the organic chemists,
inorganic chemists, physical chemists, andbioorganic chemists a core research base fromwhich they can undertake fundamental research ofinternational importance concerning the creation of
the materials. We actively promote thedevelopment of new interdisciplinary fields and are
not limited by the boundaries set by the traditional
academic fields. By way of support for research
activities we have 15 full-time faculty members, 1
university professor, 1 domestic visiting professor, 3visiting professors from overseas, 2 technicalassistans, 6 research associates (doctoral researchers),
2 administrative assistants, and 2 assistants forresearch support. RCMS is run in close association
with the laboratories of the Department ofChemistry in both research and education. Thismeans that full-time teaching staff can cooperatewith other units at the Graduate School of Scienceto give students education and research guidance,
and to make efforts to cultivate young researchers
who will be capable of carrying the future on theirshoulders in the international arena.

8

important and long-standing

andgoal in chemistry, but also

multisubstituted olefins and aromatics.

has far-reaching practical

3. Synthesis of Biologically Active

implications. Minimizing

Molecules and Natural Products

The main emphasis of our research is on theof

The synthesis of biologically active

during synthesis is criticalmolecules (drugs or drug-like molecules) andfor the future of organic

natural products is also an important subject inchemistry.

the group. Tamoxifen (anti-breast-cancer

We

have

drug),(phosphodiesterase-4

interesting materials (full-color fluorescentmetal-based

catalysts

inhibitor), CDP840 (potential drug formaterials, fluorescent nanoparticles, anddirectasthma), LUF5735 (adenosine A1 receptor

solvatofluorochromic materials) as well astransformation of C-H bonds

antagonist), and Febuxostat (drug for gout andinteresting photophysical phenomena.

(arene-sp 2 C-H, alkene-sp 2

hyperuricemia) are representative examples of

5. Synthesis and Properties of Nano-Carbon

C-H, alkane-sp3 C-H). We believe that suchmolecules that have been prepared in our

Materials

a direct transformation technology not only

group. The total synthesis of complex natural

Chemical synthesis of as-yet unexploredcontributes to the realization of "greener"

products based on C-H bond functionalization

nano-carbon materials has been a hot topic in

chemistry, but also unlocks opportunities foris also ongoing in our lab.

the group. For example, we established amarkedly different strategies in chemical

4.

synthesis.

Optoelectronic Materials

therolipramDrs. Y. Segawa (left) and J.Yamaguchi

developed a number ofOverview of Our ResearchLaboratory of Organic Chemistry I

synthesis

waste and unwanted steps

enabling

有機化学研究室

diversity-oriented

Synthesis

andProperties

ofstrategyforthesynthesisofcycloparaphenylenes, a shortest sidewall

development of new synthetic methods,

2. Programmed Chemical Synthesis

The application of our methodologies to thesegment of armchair carbon nanotubes, in a

strategies, and concepts to solve challenging

through Bond-Selective Transformation

synthesis of novel optoelectronic materials is

selective and modular fashion. Our current

synthetic problems to realize ideal chemical

Chemical synthesis has not yet reached aan ongoing endeavor in the group. These

focus is to achieve bottom-up synthesis ofsynthesis, and for generating as-yet

level where the programmed construction ofmolecules include tri- and tetraarylethene-

structurally uniform carbon nanotubes using

unexplored molecules of significant interest.

every imaginable molecule is possible. Rather

based conjugated molecules, arylenevinylene-

cycloparaphenylenes as a building block or as

Our parallel objective is to coordinate a broadthan making a specific isomer of a specificbased dendrimers, and heteroarene-corea seed. We have also developed several new

multidisciplinary

toclass of molecule, we try to advance ourstarburst pi-systems. We not only constructedcatalytic methods to functionalize fullerenes,

generate/discover new functional molecules

synthesis to a level all possible isomers ofchemical libraries of extended pi-systems, but

enabling the synthesis of new fullerene-based

useful in the development and understanding

important general types of molecules can bealso succeeded in discovering a number ofmaterials.

of pure chemistry, materials science, and life

made at will. Our approach toward this end

science. The followings are representative

is to establish bond-forming reactions withprojects.

complete bond selectivity, enabling a

1. Ideal Chemical Synthesis through C-H

programmed chemical synthesis. We have

Bond Transformation

developed several unique synthetic strategies,

effortdesigned

The selective transformation of ubiquitous
but inert C-H bonds not only represents an

including a platform strategy for programmed◆ Current Articles ◆1) M. Nambo, A. Wakamiya, S. Yamaguchi, and K. Itami, “Regioselective Unsymmetrical
Tetraallylation of C60 through Palladium Catalysis,” J. Am. Chem. Soc., 131, 15112-15113(2009).
2) S. Yanagisawa, K. Ueda, H. Sekizawa, and K. Itami, “ Programmed Synthesis of
Tetraarylthiophenes through Sequential C-H Arylation,” J. Am. Chem. Soc., 131, 14622-14623(2009).
3) H. Takaba, H. Omachi, Y. Yamamoto, J. Bouffard, and K. Itami, “Selective Synthesis of[12]Cycloparaphenylene,” Angew. Chem. Int. Ed., 48, 6112-6116 (2009).

Professor ITAMI, Kenichiro
Assistant Professor YAMAGUCHI, Junichiro
Assistant Professor SEGAWA, Yasutomo
http://synth.chem.nagoya-u.ac.jp/

94) B. Join, T. Yamamoto, and K. Itami, “Iridium Catalysis for C-H Bond Arylation of Heteroarenes
with Iodoarenes,” Angew. Chem. Int. Ed., 48, 3644-3647 (2009).
5) J. Canivet, J. Yamaguchi, I. Ban, and K. Itami, “Nickel-Catalyzed Biaryl Coupling of
Heteroarenes and Aryl Halides/Triflates,” Org. Lett., 11, 1733-1736 (2009).
6) M. Ohta, M. P. Quick, J. Yamaguchi, B. Wünsch, and K. Itami, “Fe-Catalyzed Oxidative
Coupling of Heteroarenes and Methylamines,” Chem. Asian J., 4, 1416-1419 (2009).
10

coordination numbers. The molecular designs

a unique orbital interaction between the silicon

respectively. The

exploiting these characteristic features would

moiety and the π -conjugated moiety (σ ∗-π ∗otherenable us to create new fascinating molecular

conjugation). Among them, most worthy ofsubject

isthesystems which cannot be achieved

note is 2,5-bis(bipyridyl)-substituted silole that

explorationofshows extremely high performance as an

new functional

electron-transporting material and has alreadyorganoboron

Our major target molecules are

been put into the commercial use in the organic

materials. On the basis of the characteristic

the π-electron systems consisting of theelectroluminescent (EL) display for cellular

nature of the boron atom, we are going tophones.

synthesize several types of attractive boron

by

the

ordinaryorganic

chemistry.

carbon π -conjugated framework and the

Boryl-substituted oligothiophene with an intense solid-state
fluorescence and bis(bipyridyl)silole as an excellent electrontransporting material

反応有機化学研究室
Laboratory of Organic Chemistry II

researchmain group elements. Because of π -Our current efforts have been mainlycompounds, including borole-based π-electron

electron delocalization, π -electron systems

devoted on two research subjects. One is thematerials, organic semiconductors withhave intriguing photophysical and electronic

chemistry of ladder π -electron systems

intramolecular B-N coordination, andproperties and serve as the key materials in thecontaining main group elements. The silicon-

borazine-based π -conjugated molecularorganic electronics and optoelectronics. The

bridged ladder oligo(p-phenylenevinylene)s

bundles.

embedding of the main group elements into theandselenium-containing

In our research, we also place the emphasis

π -conjugated frameworks would provide

heteroacenes are representative examples

on the development of new efficient synthetic

opportunities to modify their inherent

which we have recently synthesized. Thesemethodology. Exploiting the characteristic

properties and add new functions. Our

compounds are promising materials for organic

reactivity of the main group elements andmolecular designs rely on three features of the

EL devices and organic thin film transistors,

transition metals, we have already developed

sulfur-and

The progress in the materials science,

main group elements, that is, "unique orbital

several types of new reactions, such as the

exemplified by organic electronics andinteraction," "diversity in coordination

intramolecular reductive cyclizations of

optoelectronics, primarily depends on thenumber,"structuralacetylenic compounds that produce new π -development of new materials. The creation

characteristics."

On the basis of theseconjugated skeletons. Our ultimate goal is theof conceptually new and excellent molecular"element-organic" approaches, we aim at thecreation of newly designed functional

systems would lead to certain breakthroughs increation of new fundamental molecularmolecular systems based on the newly

these fields. From this point of view, ourmaterials for the applications in these fields.

developed own synthetic methodology. We

and"unique

research is directed at the design and synthesis

One representative accomplishment fromof new organic materials, particularly on the

our research is the silole chemistry. We havebasis of the main group chemistry. Thus,

already synthesized a variety of silole-among a number of elements, we focus ourcontaining oligomeric and polymeric materials

attention on the main group elements frombased on the newly developed silolegroup 13 to group 16, such as boron, silicon,

cyclization reaction. All of the synthesized

phosphorus, and sulfur. These elements havesilolediversity in many aspects, such as the number

photophysical and electronic properties due toof electrons included, electronegativity, andderivatives

show

interesting

Dr. A. Fukazawa

hope that this synthetic chemistry will open a
new field in materials science.
Dr. S. SAITO◆ Current Articles ◆1) A. Fukazawa, Y. Ichihashi, Y. Kosaka, and S. Yamaguchi, “Benzo[b]phosphole-Containing πElectron Systems: Synthesis Based on an Intramolecular trans-Halophosphanylation and Some
Insights into Their Properties,” Chem. Asian J., 4, 1729-1740 (2009).
2) A. Fukazawa, Y. Ichihashi, Y. Kosaka, and S. Yamaguchi, “A B-B Bond-Containing Polycyclic
π-Electron System: Dithieno-1, 2-dihydro-1, 2-diborin and Its Dianion,” J. Am. Chem. Soc.,
131, 10850-10851 (2009).
3) C.-H. Zhao, E. Sakuda, A. Wakamiya, and S. Yamaguchi, “Highly Emissive DiborylphenyleneContaining Bis (phenylethynyl) benzenes: Structure-Photophysical Property Correlations andFluoride Ion Sensing,” Chem. Eur. J., 15, 10603-10612 (2009).

Professor YAMAGUCHI, Shigehiro
Assistant Professor FUKAZAWA, Aiko
Assistant Professor SAITO, Shohei
http://orgreact.chem.nagoya-u.ac.jp/en/Home.html

114) A. Iida, and S. Yamaguchi, “Intense Solid-State Blue Emission with a Small Stokes’ Shift: πStacking Protection of Diphenylanthracene Skeleton,” Chem. Commun., 3002-3004 (2009).
5) Analogues, A. Fukazawa, H. Yamada, and S. Yamaguchi, “Phosphonium and Borate-Bridged
Zwitterionic Ladder Stilbene and Its Extended Analogues,”, Angew. Chem. Int. Ed., 47, 5582
(2008).
12

translocator systems in the membranes. The

may fail to attain their native structures. Even

extended our analyses to the protein qualitytranslocator is a protein assembly that accepts

after achieving native structures, some proteins

control in a model plant, Arabidopsis. tRNAs

a specific set of proteins by checking the

may drop out of the protein community due tohave been believed to be exported from thedestination ticket or targeting signal of thestresses placed on cells including highnucleus to the cytoplasm only once in theirprotein, opens the gate of the path for crossing

temperature. In such cases, various types oflife. However, recent results from our lab

the barrier of the membrane, and directs themolecular chaperones are called to repair theindicate that some tRNAs could shuttle

protein to the other side of the membrane. It isaberrant proteins. Besides, our lab recently

between the nucleus and cytoplasm multiple

known that the targeting signals are encoded

found that cells have a novel system to utilize

times to even after maturation. Then, what iswithin proteins themselves, but what do they

glycosylation for protein quality control. If

the biological significance of such a complex

A redox translocator, Tim40 in yeast mitochondria; Identification andlook like and how does the translocator readefforts to renature proteins fail, the aberrant

detour of tRNA molecules in cells?

X-ray structural determination have been made in our laboratory.

them out? The NMR structure of the targeting

proteins are subjected to disposal by

When we look at entire organellar

signal in a complex with its cognate receptor

degradation systems. The questions of how

structures, their shapes, numbers and positions

subunit of the translocator revealed in our lab

one can discriminate normal and aberrantchange significantly and frequently in response

opened up the way to understanding of theproteins and what makes the final judgment toto intra- and extra-cellular conditions. Somemechanism of targeting signal recognition.

determine the fate of proteins is one of theorganelles can divide and fuse each other.

central issues in molecular cell biology.

However, it still remains obscure what

生物化学研究室
Laboratory of Biochemistry

Lipid

of

the

membranes

Proteins are major key players in the living

surrounding organelles do not allow passage of

It also remains vague if functions ofmediates such morphological alteration ofsystems. They are independent entities thatsuch large molecules as proteins. Thenmolecular chaperones and translocators haveorganelles and what are the underlying

start with spontaneous folding, acquire native

questions may arise: how can the organellar

profound biological significance at the level ofmechanisms. We have recently found a new

functional structures, and end by random

proteins go through the lipid bilayer

multicellular organisms as well. We have thus

chaperone that mediates nuclear membrane

degradation --- this classical view of proteins

efficiently,

may not be true.

Rather, accumulatedtranslocation? Another important issue is whatevidence suggests that the life of proteins

drives the vectorial movement of proteins. Is

Our lab is making every endeavor to address

depends on other players and that many

that a mechanistic molecular motor or

the questions listed up above by using various

proteins cannot become functional by

Maxwell's demon utilizing the Brownian

techniques that cover biochemistry, molecularthemselves. The cell therefore provides

movement?

Proteins often have to movebiology, cell biology, structural biology, andelaborate systems to monitor, assist, andacross more than one membrane to reach their

genetics etc. We are also developing a newcontrol the behaviors of proteins and to makefinal destinations. In such cases, multiple

them function properly.

translocators in distinct membranes need toMany newly synthesized proteins have toreach their specific sites of functions, i.e. such

and

what

mediates

but how do they cooperate?

ER, and the nucleus, before they fold and/or

can proteins live their peaceful lives? Life ofassemble into functional structures. Since theproteins is not so simple and some proteinspermeability

barrieroforganellar

membrane(s), proteins have to move across themembranes with the aid of so-called

Professor ENDO, Toshiya
Associate Professor YOSHIHISA, Tohru
Associate Professor NISHIKAWA, Shuh-ichi
http://biochem.chem.nagoya-u.ac.jp/

of the chaperone-mediated membrane fusion.

Drs. S. Nishikawa (left) and T. Yoshihisa

methodology to deal with these issues in thelife of proteins and organelle biogenesis.

cooperate to mediate efficient translocation,
Once delivered to appropriate destinations,

cytosol, the sites of protein synthesis, by thefusion, and are trying to reveal the mechanism

thisorganelles as mitochondria, chloroplasts, theorganellar interior is separated from the13bilayers◆ Current Articles ◆1) D. Maruyama, T. Endo, and S. Nishikawa, “Bip-mediated polar nuclei fusion is essential for the
regulation of endosperm nuclei proliferation in Arabidopsis thaliana,” Proc. Natl. Acad. Sci.
USA., 107, 1684-1689 (2010).
2) K. Yamano, S. Tanaka-Yamano, and T. Endo, “Mdm10 as a dynamic constituent of the
TOB/SAM complex directs coordinated assembly of Tom40,” EMBO Rep. in press (2010).
3) S. Kawano, K. Yamano, M. Naoe, T. Momose, K. Terao, S. Nishikawa, N. Watanabe, and T.
Endo, “Structural basis of yeast Tim40 as an oxidative translocator in the mitochondrialintermembrane space,” Proc. Natl. Acad. Sci. USA., 106, 14403-14407 (2009).
4) M. Sakoh-Nakatogawa, S. Nishikawa, and T. Endo, “Roles of protein disulfide isomerasemediated disulfide bond formation of yeast Mnl1p in ER-associated degradation,” J. Biol.
Chem., 284, 11815-11825 (2009).
5) Y. Tamura, Y. Harada, T. Shiota, K. Yamano, K. Watanabe, M. Yokota, H. Yamamoto, H.
Sesaki, and T. Endo, “Tim23-Tim50 pair coordinates functions of translocators and motor
proteins in mitochondrial protein import,” J. Cell Biol., 184, 129-141 (2009).
14

The crystal structure of asymmetric catalyst

特別研究室
Noyori Laboratory

Our research group has consistently focusedlaboratory are directed toward (1) invention of

on molecular catalysis and, consequently,

efficient synthetic methods, strategies, andcontributed in many ways to the progress ofconcepts to solve challenging synthetic

modern chemistry.

problems,(2)cost-effective

and/orDrs. H. Naka (left)
and
S. Tanaka

Professor Noyori is well known for his

programmable synthesis of various classes of

initiation, development and establishment ofimportant compounds, (3) creation ofasymmetric catalysis using chiral metal

significant

inter-molecular recognition, (4) synthesis ofcomplexes. In particular, chemistry based on

properties orpreviously unexplored molecules that are

BINAP ligand has been practiced in researchfunctionsarchitecturally interesting, (5) discovery oflaboratories worldwide as well as on an(catalysts andnew functional molecules (or molecularindustrial scale. Other major accomplishments

materials)

assemblies) useful in the development andin this area include the development ofutilizingunderstanding of materials science and life

practical asymmetric hydrogenation of olefins

synergisticscience.

and ketones; the demonstration of the generaleffects

utility of dynamic kinetic resolution in

intra-andasymmetric catalysis; the discovery of highlyofDr. S. Saito

Chemistry is not merely a science of making

enantioselective addition of dialkylzincs toobservations in order to better understandaldehydes catalyzed by chiral amino alcohols,

Nature. It is creative and productive. We

and the elucidation of the molecular◆ Current Articles ◆chemists are proud of our ability to create highmechanism of the chirality amplification

values from almost nothing on the basis ofphenomenon. These methods have foundaccumulated scientific knowledge. Our field of

application in syntheses of numerous important

study has greatly enhanced the quality of life

products including menthol, carbapenem

1) C. A. Sandoval, F. Bie, A. Matsuoka, Y. Yamaguchi, H. Naka, Y. Li, K. Kato, N. Utsumi, K.
Tsutsumi, T. Ohkuma, K. Murata, and R. Noyori, “Chiral η 6-Arene/N-TosylethylenediamineRuthenium(II) Complexes: Solution Behavior and Catalytic Activity for AsymmetricHydrogenation,” Chem. Asian J., in press (2010).

worldwide by providing an impressive range

antibiotics, and prostaglandins. More recentof useful man-made substances and materials.

achievements extended to the DNA synthesis

Despite the extraordinary masterworks of total

using organometallic methodologies, thesynthesis in the last century, the development

catalytic hydrogenation of carbon dioxide in itsofsynthetic

supercritical state, the environmentally benign

methodologies is still in its infancy. The needoxidation methods using a tungsten catalyst infor efficient and practical synthesis remains

an aqueous hydrogen peroxide solution, andone of the greatest intellectual challenges withthe contribution to the brain science researchwhich chemists are faced in the 21st Century.

via the synthesis of prostaglandins by the

The achievement of this goal will require thethree-component coupling.

practical

andefficienthighest level of scientific creativity, insightand understanding.

The current research programs of our2) C. A. Sandoval, Q. Shi, S. Liu, and R. Noyori, “NH/π Attraction: A Role in AsymmetricHydrogenation of Aromatic Ketones with Binap/1,2-Diamine-Ruthenium(II) Complexes,” Chem.
Asian J., 4, 1221-1224 (2009).
3) C. A. Sandoval, Y. Li, K. Ding, and R. Noyori, “The Hydrogenation/Transfer Hydrogenation
Network in Asymmetric Reduction of Ketones Catalyzed by [RuCl2(binap)(pica)] Complexes,”
Chem. Asian J., 3, 1801-1810 (2008).
4) S. Oishi, J. Yoshimoto, and S. Saito, “Importance of Open Structure of Non-metal Based
Catalyst in Hydrogen Bond-promoted Methanolysis of Activated Amide: Structure Dynamics
between Monomer and Dimer Enabling Recombination of Covalent, Dative, and Hydrogen
Bonds,” J. Am. Chem. Soc., 131, 8748-8749 (2009).
5) A. Goto, K. Endo, and S. Saito, “RhI-catalyzed Hydration of Organonitriles Under Ambient
Conditions,” Angew. Chem. Int. Ed., 47, 3607-3609 (2008).
6) A. Goto, K. Endo, Y. Ukai, S. Irle, and S. Saito, “Rh I -catalyzed Aldol-type Reaction ofOrganonitriles Under Mild Conditions,” Chem. Commun., 2212-2214 (2008).
7) J. Yoshimoto, C. A. Sandoval, and S. Saito, “Aqua Aminoorganoboron Catalyst: Engineering
Single Water Molecule to Act as an Acid Catalyst in Nitro Aldol Reaction,” Chem. Lett., 37,
1294-1295 (2008).

Professor NOYORI, Ryoji
Associate Professor SAITO, Susumu
Assistant Professor NAKA, Hiroshi
Assistant Professor TANAKA, Shinji
http://noy.chem.nagoya-u.ac.jp/Noy_e/Top.html

158) K. Kobayashi, M. Ueno, H. Naka, and Y. Kondo, “SN2´ Reaction of Organozinc Reagents
Activated by Catalytic tBu-P4 Base in the Presence of LiCl,” Chem. Eur. J., 15, 9805-9809(2009).
9) H. Naka, D. Koseki, and Y. Kondo, “Catalytic Deprotonative Functionalization of Propargyl
Silyl Ethers with Imines,” Adv. Synth. Catal., 350, 1901-1906 (2008).
10)H. Naka, J. V. Morey, J. Haywood, D. Eisler, M. McPartlin, F. García, H. Kudo, Y. Kondo, M.
Uchiyama, and A. E. H. Wheatley, “A Mixed Alkyl-amido Aluminate as a Kinetically Controlled
Base,” J. Am. Chem. Soc., 130, 16193-16200 (2008).
16

nanotubes (DWNTs), which is the thinnest
multi-wall carbon nanotubes, have been
A model structure of metal containing fullerenes inserted in a single-wall carobon nanotube

nanotube-peapods. The followings are some

物理化学研究室
Laboratory of Nano-Structured Materials

details on these research projects.
Synthesis, characterization and applicationsof endohedral metallofullerenes:
The structures of endohedral metallo-

Since today's device engineering is facing

fullerenes have been studied by using 13 C

technical and economic difficulty in further

NMR, UHV-STM/STS (scanning tunnelingminiaturizing electronic devices with themicroscopy/spectroscopy) and synchrotron X-

current fabrication technologies, the need forray diffraction. For example, we havealternative device-channels is particularly

synthesized and characterized for the first time

imminent. Fullerenes and carbon nanotubes"metal-carbide" metallofullerenes such as

have been considered as one of the most

(Sc2C2)@C84 and (Y2C2)@C82 and found that a

promising

today's

C 2 cluster is encapsulated in Sc 2 @C 84 andnanoscience and nanotechnology since

Y2@C82, respectively. This is the first example

Kraetschmer and Huffman's first report on thethat C 2 radical is trapped in a molecule.

macroscopic synthesis of C60 in 1990. In fact,

Furthermore, our recent UHV-STM/STS

fullerenes and carbon nanotubes have beenstudies show that metallofullerenes do not

successfully used for nanometer-sized devices

rotate at temperatures below 50 K onsuch as diodes, transistors, and random

Si(100)2

memory cells during the past several years.

surfaces.

nano-materialsinDuring the past decade, we have been trying
to elucidate structures andelectronic

the key carbon nanotubes materials in theapplication of field-emission display and tips
for scanning probe microscopy, the synthesisof high-quality DWNTs is particularly needed.
To apply the DWNTs synthesized in ourlaboratory in these rapidly growing area, weDrs. T.Tomiyama (left) R. Kitaura.(center) and Y.Miyata

have been collaborating with various industrial
companies in Japan and abroad.

synthesized in high-yield. Such peapods

Synthesis, characterization and devicematerials have been found to possess not only

applications of nanotube-peapods:

unique structural properties but more

Carbon nanotubes encapsulating fullerenes,

importantly novel electronic transport

metallofullerenes and other novel molecules

properties as revealed by HRTEM-EELS(the so-called "peapods") have been(high-resolution transmission electron microscopy/electron energy loss spectroscopy),
STM/STS and FET (field effect transistors)
measurements. We have found that peapods
encaging metallo-fullerenes exhibit the bandgap modulation due to the electron transferfrom metallofullerenes to carbon nanotubes.

1 hydrogen-terminated clean

Such peapods have been applied to FET withnovel device properties.

Selective and high-yield synthesis of carbon
nanotubes:

properties of the so-called nano-carbon

Single-, double- and multi-wall carbon

materials, such as fullerenes, endohedral

nanotubes have been synthesized selectively inmetallofullerenes, carbon nanotubes andhigh-yield by using the methods developed in

nanotube-peapods. We have paid particular

our laboratory such as zeolite-CCVD (catalyst-

attentions to (1) synthesis, characterization andsupported chemical vapor deposition), HFCVD

applications of endohedral metallofullerenes;(hot-filament assisted CVD) and HTPAD(2) selective and high-yield synthesis of(high-temperature pulsed arc-discharge)

carbon nanotubes, and (3) synthesis,

methods. In particular, double-wall carbon

characterization and device applications ofsynthesized in high-yield. Since DWNTs are◆ Current Articles ◆1) R. Kitaura, R. Nakanishi, T. Saito, H. Yoshikawa, K. Awaga, and H. Shinohara, “High Yield
Synthesis of Ultrathin Metal Nanowires in Carbon Nanotubes,” Angew. Chem. Int. Ed., 48,
8298-8302 (2009).
2) J. H. Warner, Y. Ito, M. H. Ruemmeli, T. Gemming, B. Buechner, H. Shinohara, and G. A. D.
Briggs, “One-Dimensional Confined Motion of Single Metal Atoms inside Double-Wall Carbon
Nanotubes,” Phys. Rev. Lett., 102, 195504-1-4 (2009).
3) N. Fukui, Y. Suwa, H. Yoshida, T. Sugai, S. Heike, M. Fujimori, Y. Terada, T. Hashizume, and
H. Shinohara, “Moire Image Patterns on Doubel-Walled Carbon Nanotubes Observed by
Scanning Tunnneling Microscopy,” Phys. Rev. B, 79, 125402-1-5 (2009).

Professor SHINOHARA, Hisanori
Associate professor KITAURA, Ryo
Assistant professor TOMIYAMA, Tetsuo
Assistant professor MIYATA, Yasumitsu
http://nano.chem.nagoya-u.ac.jp/

174) T. Shimizu, J. Haruyama, K. Nozawa, T. Sugai, and H. Shinohara, “Possible Formation ofInterlayer Nano-p-n Junctions and Quantum Dot in Double-Wall Carbon Nanotube with
Electrode Contacts to Different Layers,” Appl. Phys. Lett., 94, 143104-1-3 (2009).
5) L. G. Moura, L. M. Malard, M. A. Carneiro, P. Venezuela, R. B. Capaz, D. Nishide, Y. Achiba,
H. Shinohara, and M. A. Pimenta, “Charge Transfer and Screening Effects in Polyynes
Encapsupated inside Single-Wall Carbon Nanotubes,” Phys. Rev. B, 80, 161401-1-4 (2009).
18

molecules exposed to an intense laser fields

fireworks in the night sky, the momenta of thecomparable with the intramolecular electric

resultant fragment ions reflect sensitivly thefields show a variety of exotic features, such as

molecular geometry just before the Coulomb

the formation of “light-dressed states” and the

explosion. This has been successfully applied

generation of “attosecond” (10-18 s) light pulses.

toWe are exploring a new research field ofGeneration of few-cycle intense laser pulses with a hollow fiber.

theultrafast

acetylene-vinylidene

isomerization in C2D22+, DCCD2+↔D2CC2+.

chemistry by utilizing the full functions ofAnother approach being persued in ourlight. Our laboratory aims (i) to seek andlaboratory utilizes the laser high-orderclarify new phenomena in gas, condensed, andharmonics, which have unique features notcontrol of polyatomic molecules has beensolid phases as well as on interfaces by new

avaiable with other sources: i) a high photon

demonstrated in our laboratory by changing thestate-of-art spectroscopic techniques, and (ii) toenergy up to several keV, ii) an extremelyorientation to the direction of laser polazation,find new chemical reaction pathways and theirshort pulse duration in the “attosecond”

which shows that the reaction can be controledcontrol by using strong laser pulses as theregime, iii) a high-quality spatiotemporalby steering electrons in the molecular frame.

reaction fields.

coherence, and iv) simple and precise

Basic understanding of the molecularsynchronization with other laser light sources.

dynamics in intense laser fields is important in(i) Visualization of ultrafast molecular

Researches using free electron laser (FEL) in

further developments.

dynamics by femto- and atto-second pulses

extreme ultraviolet are also in progress.

Real-time probing of molecular dynamics is of

Dr. Y. Ouchi(iii) Structural studies of surfaces andfundamental importance in understanding of(ii) Chemical reaction control with strong

chemical reaction processes and in theirlaser reaction fields

interfaces including their dynamics.
Second order nonlinear spectroscopies suchcontrol. We are developping novel approaches

Strong preturbation from the intense laser

as optical second harmonic generation (SHG)

to visualize ultrafast dynamics of polyatomic

fields changes the landscape of the potential

and sum-frequency generation (SFG) aremolecules with unprecedented time resolution.

energy surfaces as the interaction is

powerful tools to study surfaces and interfaces.

Time-resolved Coulomb explosion imaging iscomparable with the Coulombic fields within a

They are non-destructive and surface- orUnderstanding of light-matter interaction is

one such approach, which allows us to discuss

molecule. This may be compared with theinterface-sensitive up to a submonolayer

central in modern chemistry. Spectroscopy

how the molecular structure changes during thefunction of an enzyme in a biosynthetic

thickness, and do not require any vacuum

utilizing the responses of matter upon thereaction in real time. When irradiated byprocess, which modifies the potential of thecondition. With these and other synchrotronchanges in the “wavelength” of light, forintense laser pulses (~1015 W/cm2), molecules

reactants by an electrostatic interation.

based surface analytical techniques, we areexample, serves as a versatile tool to probe theusually undergo ultrafast fission process called

Flexibility in laser waveform design offers ainvestigating the molecular arrangements ofstate of the matter in various phases, thus

“Coulomb explosion” after multiple ionization.

unique opportunity to seek new reaction

organic functional molecules, polymer films,

contributing the rapid development of material

As may be imagined from the anaology ofpathways and their control. A simple reaction

and the surface layer of ionic liquids.

光物理化学研究室
Laboratory of Photo-Physical Chemistryscience in the last decades. The advent oflaser having a high spatio-temporal coherence
has opened a new research field, which
additionally uses the “intensity” of light as a
new parameter. Recent studies revealed that◆ Current Articles ◆1) A. Hishikawa, A. Matsuda, M. Fushitani, and E. J. Takahashi, “Visualizing Recurrently
Migrating Hydrogen in Acetylene Dication by Intense Ultrashort Laser Pulses,” Phys. Rev.
Lett., 99, 258302 (2007).
2) A. Hishikawa, E. J. Takahashi, and A. Matsuda, “Electronic and Nuclear Responses of Fixed-inspace H2S to Ultrashort Intense Laser Fields,” Phys. Rev. Lett., 97, 243002 (2006).

Professor HISHIKAWA, Akiyoshi
Associate Professor OUCHI, Yukio
http://mat.chem.nagoya-u.ac.jp/index.html

193) T. Iwahashi, T. Miyamae, K. Kanai, K. Seki, D. Kim, and Y. Ouchi, “Anion Configuration at the
Air/Liquid Interface of Ionic Liquid [bmim]OTf Studied by Sum-Frequency Generation
Spectroscopy,” J. Phys. Chem. B, 112, 11936-11941 (2008).
4) T. Iwahashi, T. Nishi, H. Yamane, T. Miyamae, K. Kanai, K. Seki, D. Kim, and Y. Ouchi,“Surface Structural Study on Ionic Liquids Using Metastable Atom Electron Spectroscopy,” J.
Phys. Chem. C. 113, 19237-19243 (2009).
20

Studies on Molecular Spin Functions

分子機能化学研究室
Laboratory of Advanced Materials

Study of molecule-based magnetic

state. However, usual organic radical crystal

materials has also been improved in theshows an insulating property due to thelast three decades. While such materials

electron-electron repulsion and/or electron-

had been considered to be far fromlattice interaction in the solid state. Inversely,

magnetic substances, discoveries of

if some trick to remove the cause of theorganic ferromagnets, photomagnets,

insulating property is introduced in the organic

single-molecule magnets, etc. continued

radical crystal, conductivity will be recovered

recently. After these fundamental

drastically. This is our fundamental strategy on

discoveries, organic electronic devises,organic radical electronics. We are performing

such as organic light emitting diode,molecular design, chemical syntheses,organic solar cell, and organic transistor,

structural analyses, and physical measurements

have attracted much attention. While theon these materials, aiming for organic

discharging capacity was an extremely highstudies on organic conductors, supertransistors and solar cells driven by completely

value of ca. 250 Ah/kg, which is higher thanconductors, and magnets mainly focus on static

new principles. We are also developing novelthat of a usual lithium ion battery (180 Ah/kg).

intermolecular interactions in single crystals,

analytical method to reveal the individual

To improve these battery performances, wedevelopment of organic devises require theproperty of newly synthesized materials.

carry out material research on metal complex

integration of several fundamental properties

2) Molecular Cluster Batteries

clusters for cathode active materials. We also

Dr. M. M. Matsushita

Our modern life is made wealthy by a lot oflinking with electron and/or energy transfer in

Recently, much attention has been focused

develop the methodology of in-situ physicalnew materials. It is easy to recognize that wemolecular thin films fabricated on electrodeon the creation of new energy systems, such asmeasurements during charging/discharging to

are indebted to chemistry as a major discipline

surfaces. Organic thin films on electrodehigh-performance rechargeable batteries, as adetermine the valence change in Mn ions andin material sciences. While the neededsurface is also interested from the viewpoint ofsolution

structural change in the cluster.

materials of the times may change year bysolid state electrochemistry, which isenvironmental crises. To achieve both highyear, the demand to chemistry for producing

applicable for rechargeable batteries.

capacity and rapid charging/discharging, we

new materials would continue. The mission of

Nowadays, energy and ecology become serious

have fabricated rechargeable molecular cluster

the laboratory of advanced materials is to

global issues and organic electronics isbatteries,

research various electronic functions of

expected to be a key technology to achieve the[Mn12O12(CH3COO)16(H2O)4] were utilized as

molecule-base and nano-scale materials. Thesesustainable society. Since the major part ofa cathode active material. They are well known

materials are advantageous in manifestations

energy resources in the world derive from theas single molecule magnets and undergo multi-of controllable properties and quantum

solar energy, we are attempting to solve above

step redox reactions. The first Mn12 battery

phenomena.

problems refering the energy conversion

exhibited a rechargeable battery performancesystems in nature.

with a capacity of ca. 90 Ah/kg, while the first

Scienceandtechnology

oforganic/molecular electronic devices have

in

the

globalwhichenergyMn12

andclusters

Dr. H. Yoshikawa

1) Organic Radical Electronics.

been developed in recent years. This field was

An organic radical has unpaired electron andfounded by researches of molecular

it can be a conduction electron in the solid

semiconductors, metals and superconductors.

to◆ Current Articles ◆1) H. Fujimoto, M. M. Matsushita, and K. Awaga, “Electrochemical Field-Effect Transistors ofOctathio[8]Circulene Robust Thin Films with Ionic Liquids,” Chem. Phys. Lett., 483, 81-83(2009).
2) H. Yoshikawa, S. Hamanaka, Y. Miyoshi, K. Kondo, S. Shigematsu, N. Akutagawa, M. Sato, T.
Yokoyama, and K. Awaga, “Rechargeable Batteries Driven by Redox Reactions of Mn12
Clusters with Structural Changes: XAFS Analyses of the Charging/Discharging Processes in
Molecular Cluster Batteries,” Inorg. Chem., 48, 9057-9059 (2009).

Professor AWAGA, Kunio
Associate Professor MATSUSHITA, Michio M.
Assistant Professor YOSHIKAWA, Hirofumi
http://www.chem.nagoya-u.ac.jp/awagak/

213) A. Iwasaki, L. Hu, R. Suizu, H. Yoshikawa, and K. Awaga, “Interactive Radical Dimers in
Photoconductive Organic Thin Films,” Angew. Chem. Int. Ed., 48, 4022-4024 (2009).
4) Q.-L. Ye, H. Yoshikawa, S. Bando, and K. Awaga, “Green Magnetite (Fe3O4): Unusual OpticalMie Scattering and Magnetic Isotropy of Submicron-Size Hollow Spheres,” Appl. Phys. Lett.,
94, 063114 (2009).
22

macroscopic phenomena of

DNA with metal ligands instead of canonicalThis allows one

materials.

nucleobases forms double helical structure

toProgramming of organic

through metal-mediated base pairing in theincreaselinkage of molecular functions

presence of appropriate metal ions. Actually,

complexity andis nothing more or less than tometal ions could be arrayed in the center of thediversity

control of the molecularduplex site-selectively along with thep o t e n t i a linteractions and reactions inprogrammed sequences of the ligand-typemolecular arrays

three-dimensional

space.

nucleotides. The metal complexes have been

under

Biological system generates

quantitatively incorporated into the middle of acontrol of the

biopolymers such as DNA,DNA duplex, resulting in the formation of asequence and theprotein, and polysaccharide without any

ferromagnetic chain by the line-up of

distance between

dispersion in “ number” , “ composition” ,assembled metal complexes stacked within thethe“sequence”, and “direction” of the buildingDNA

throughmolecular units. Precise assembly of molecular

blocks such as nucleosides, amino acids, andthermodynamically stable self-assembly. The

units is becoming increasingly important as asugars. These molecules organize with highly

strategy for programmable metal arrays can be

key strategy to develop functional materials,“selective” and “specific” spatial arrangement.

further extended to quantitative and site-

molecular devices and catalysis. We are

The ultimate goal of molecular architecture

Hence, the structural motifs of biopolymers,

selective array of heterogeneous metal ions.

continuously creating basic concepts of higher

is to arrange atoms and/or molecules precisely

which have been optimized by evolution over

Peptides and other biopolymers are alsohierarchy control of molecular assembly andin space and to make it operate efficiently,

several billion years, have great potential aspromising molecules to be functional templates

functions by innovating strategies to create

which is ingredient essential for expansion offunctional templates for programmable self-

for molecular assembly and could expand

materials used in other field such as surface

nanoscience and nanotechnology. Ourassembly to generate well-defined molecular

design of architectures. We have recently

sciences, electronic engineering, biosciences,laboratory is concerned with developing newarchitectures. More over, because of their easy

reported discrete one dimensional metal wireand so on.

types of molecular level architectures tosolid-phaseformation via duplexation of artificial peptides.

control and influence function and properties

oligonucleotides and peptides became of

by basic ideas and concepts across theinterest as well-defined molecular scaffolds on

traditional branches of the molecular,

the multi-nanometer scale. Hence, besides thebiomolecular and materials sciences: (1) Bio-role in biology, biopolymers have also become

inspired supramolecular chemistry (synthesisof interest in other areas such as nanoscience,and functionalization of artificial DNAs andnanotechnology, and materials science. Frompeptidesandthe point of view, we have developed anphysiological control); (2) Self-assembled

artificial metallo-DNA, in which hydrogen-molecular architecture involving organic,

bonded base pairing was replaced by metal-

inorganic and biomolecular components; (3)mediated one, thereby creating a novel base-

Interactive control between nanoscalepairing motif in duplex DNA. The artificial

Precise Array of Metal Complexes on Bio-Inspired Templates

分析化学研究室
Laboratory of Analytical Chemistry

towardnanomaterials(molelcular) properties and meso- orsynthesis

protocols,

right-handed

helix

strongly
theDr. Y. Yamadaof

preciseindividual

Dr. S. Kawano◆ Current Articles ◆1) Y. Takezawa, W. Maeda, K. Tanaka, and M. Shionoya, “Discrete Self-Assembly of Iron(III)Ions inside Triple-Stranded Artificial DNA,” Angew. Chem. Int. Ed., 48, 1081-1084 (2009).
2) Y. Takezawa, K. Tanaka, M. Yori, S. Tashiro, M. Shiro, and M. Shionoya, “Soft MetalMediated Base Pairing with Novel Synthetic Nucleosides Possessing an O,S-Donor Ligand,” J.
Org. Chem., 73, 6092-6098 (2008).
3) R. Miyake, S. Tashiro, M. Shiro, K. Tanaka, and M. Shionoya, “Ni(II)-Mediated Self-Assemblyof Artificial β-Dipeptides Forming a Macrocyclic Tetranuclear Complex with Interior Spaces
for In-Line Molecular Arrangement,” J. Am. Chem. Soc., 130, 5646-5647 (2008).
4) K. Tanaka, T. Tanaka, T. Hasegawa, and M. Shionoya, “A Closed-packed, Highly-insulating
Organic Thin Monolayer on Si(111),” Chem. Lett., 37, 440-441 (2008).
5) K. Tanaka, K. Kaneko, Y. Watanabe, and M. Shionoya, “A Template-Directed Synthetic
Approach to Halogen-Bridged Mixed-Valence Platinum Complexes on Artificial Peptides in
Solution,” Dalton Trans., 2007, 5369-5371.

Professor TANAKA, Kentaro
Assistant Professor YAMADA, Yasuyuki
Assistant Professor KAWANO, Shin-ichiro
http://supra.chem.nagoya-u.ac.jp/

236) K. Tanaka and M. Shionoya, “Programmable Metal Assembly on Bio-Inspired Templates,”
Coord. Chem. Rev., 251, 1731-2742 (2007).
7) K. Tanaka, G. Clever, Y. Takezawa, Y. Yamada, C. Kaul, M. Shionoya, and T. Carell,“Programmable Self-Asembly of Metal Ions Inside Artificial DNA Duplexes,” Nature
Nanotech., 1, 190-194 (2006).
24

無機化学研究室
Laboratory of Inorganic Chemistryscope, yet rigorous in approach, encompassing

thiolate ligands are often utilized as supporting

bioinorganic chemistry, organometallic chemistry,

ligands. A tipical recent example is a novel

materials chemistry, and the interface with othermolybdenum(II) compound with a metal center π-

disciplines. We are aiming at a comprehensive

sandwiched by two arylthiolato ligands which

and fundamental understanding of the rolefeatures a highly labile aryl-Mo bond. Anothertransision metals play in various inorganic

specific example is an electron-deficientsystems, in order to design more efficient

ruthenium(II) complex with the bulky 2,6-

characteristic non-linear optical properties.

synthesies of the target compounds.

dimesitylphenyl thiolate ligand. The compound

Furthermore, use of thiolate/thioether hybrid

In the area of bioinorganic chemistry, ourserves as precursor to coordinatively unsaturated

ligands was found to give large-size iron andresearch is focused on metalloenzymes consisting

species in dual capacity; lability of the ipso-carbon

nickel clusters and 1-dimensional polymers. Anof transition metal clusters with sulfur-donor

and reversible dissociation/association of theinteresting feature of the polymers is theirligands and/or cystein; nitorogenase, CO

thiolate ligand. We have also synthesized a seriessolubility in toluene by virtue of coordination of

dehydrogenase,synthase,of S-bridged dinuclear W-Ru complexes that are

thioether-type sulfur atoms, and that the polymerichydrogenase, molybdoenzyme, and iron-sulfur

capable of heterolytic activation of molecular

structure is regenerated upon recrystallization.

proteins. We are actively seeking to reproduce thehydrogen under mild conditions, mimicking thefascinating structures and reactivity of their activefunction of hydrogenase.

acetyl-CoA

Drs. T. Matsumoto (left) and Y. Ohki

Modern inorganic chemistry is a realm of
unlimited possibility. Our research laboratory

sites in vitro. Recently we have successfully

The third major area of research concerns thedeals with nearly all the elements in the periodic

Transition metal chemistry and modern

synthesized an [8Fe-7S] iron-sulfur cluster, whichconstruction of gigantic nano-scale transition

table. We endeavor to discover something new,inorganic chemistry are rapidly growing andreproduces the core geometry of P-cluster inmetal sulfide clusters and polymers. We havesomething important, and something to fulfil ourappealing areas of research. Systems ofnitrogenases.

The isolation of this is a

developed a new synthetic strategy to preformed

intellectual curiosity in chemistry.

importance include:metalloproteins that play

breakthrough in synthetic inorganic chemistry,molybdenum/iron/sulfide cubes, leading to anable and dedicated students, postdocs and young

important roles for life, transition metal catalysts

indeed the geometry of the cluster is so unusual

unprecedented cyclic tricubane and higher

researchers from various countries are responsoble

that are indispensable to organic syntheses and toamong the known naturally occurring iron-sulfur

clusters. Also synthesized are heterometallic

for the excellent research atmosphere of ourenvironmental benignity, high-temperatureclusters that the structure has been thought to exist

sulfide clusters and polymers showing

laboratory, with an international flavor.

superconductors such as copper oxides andonly in certain protein environments. We haveniobium chalcogenides, and non-linear optical andalso achieved synthesis of Mo/Fe/S clusters, themagnetic/electronic materials of practical use.

structures of which not yet reproducing exactry,

These are highly organized inorganic substances

but, are close to the FeMo-co core of nitrogenase.

with transition metals.
Our research group has been engaged in such

The second major area of our research isorganometallic chemistry.

We have been

emerging areas of inorganic chemistry. Specificparticularlyininterests include structures and reactions that arecoordinatively unsaturated and/or chemicallyunique to the active sites of various metallo-

flexible complexes which show high reactivity

enzymes, the development of new, catalyticallytoward organic/inorganic substrates. Bulky

active organometallic compounds, and thesynthesis of inorganic supramolecules relevant to
nano-sciences. The research subjects are broad ininterested

developing

A group of◆ Current Articles ◆1) Y. Ohki, M. Imada, A. Murata, Y. Sunada, S. Ohta, M. Honda, T. Sasamori, N. Tokitoh, M.
Katada, and K. Tatsumi, “Synthesis, Structures, and Electronic Properties of [8Fe-7S] Cluster
Complexes Modeling the Nitrogenase P-Cluster,” J. Am. Chem. Soc., 131, 13168-13178 (2009).
2) T. Hakoyama, K. Niimi, H. Watanabe, R. Tabata, J. Matsubara, S. Sato, Y. Nakamura, S.
Tabata, L. Jichun, T. Matsumoto, K. Tatsumi, M. Nomura, S. Tajima, M. Ishizuka, K. Yano, H.
Imaizumi-Anraku, M. Kawaguchi, H. Kouchi, and N. Suganuma, “Host Plant Genome
Overcomes the Lack of a Bacterial Gene for Symbiotic Nitrogen Fixation,” Nature, 462, 514518 (2009).
3) M. Ito, M. Kotera, T. Matsumoto, and K. Tatsumi, “Dinuclear Nickel Complexes Modeling theStructure and Function of the Acetyl CoA Synthase ActiveSite,” Proc. Nat. Acad. Sci. (USA),106, 11862-11866 (2009).
4) Y. Ohki, T. Hatanaka, and K. Tatsumi, “C-H Bond Activation of Heteroarenes Mediated by aHalf-Sandwish Iron Complex of N-heterocyclic Carbene,” J. Am. Chem. Soc., 130, 1717417186 (2008).

Professor TATSUMI, Kazuyuki
Associate Professor OHKI, Yasuhiro
Assistant Professor MATSUMOTO, Tsuyoshi
http://www.chem.nagoya-u.ac.jp/ic/

255) Y. Ohki, M. Sakamoto, and K. Tatsumi, “Reversible Heterolysis of H2 Mediated by an MS(thiolate) Bond (M = Ir, Rh): A Mechanistic Implication for [NiFe] Hydrogenase,” J. Am.
Chem. Soc., 130, 11610-11611 (2008).
6) T. Matsumoto, Y. Nakaya, N. Itakura, and K. Tatsumi, “A Functional Hydrogenase Model:
Reversible Interconversion of H2 and H2O by a Hydroxo/Slfido-Bridged Dinuclear RutheniumGermanium Complex,” J. Am. Chem. Soc., 130, 2458-2459 (2008).
26

activities. For example, some mutants are able

penetrate into the ferritin cavity through theto catalyze sulfoxidation and epoxidation withsize restricted channels. The crystal structure

high enantiomeric selectivity (up to 97%).

of Pd•apo-Fr has been refined to 1.65Å

More importantly, we have characterized theresolution. We have further found that

active intermediates responsible for thePd(allyl)•apo-Fr composites catalyze theoxidations.

Suzuki-Miyaura coupling in an aqueous

production and purification of VnfA.

P450 BSβ:

solution.

Spectroscopic

Functional analysis of a transcriptional

characterization of the recombinant VnfA in

regulator for nitrogenase

vitro and in vivo show that VnfA function

P450 BS β from Bacillus subtilis utilizes
hydrogen peroxide for the hydroxylation of

Dr. H. Nakajima

andbiochemical

fatty acids. The crystal structure of P450BSβ

The conversion of atmospheric nitrogen into

requires iron-sulfur (Fe-S) clusters as areveals the electrostatic interaction of thea usable form to plants and microorganisms is

prosthetic group. This is the first example as

guanidium group of Arg-242 located nearbya part of fundamental processes in the nitrogen

nitrogenase regulators involving bears a Fe-S

the heme with the terminal carboxyl group of

circuit on earth. Scientific studies on thecluster. Besides the interesting prosthetic

fatty acid. In nature, P450BSβ does not oxidize

nitrogen fixation is classified into two parts ingroup, we have revealed that VnfA bears

foreign compounds such as styrene and ethyl

general. Our focus is on the regulation

uniquebenzene due to the lack of the carboxylic acidmechanism of the nitrogenases in free-living

transcriptional regulator. Our present concern

We have been engaged the design andin the substrate. However, we have recently

diazotroph, Azotobacter vinelandii. Spending

is in the overall sensing process of theconstruction of metallo-enzymes on the basis

demonstrated that P450BSβ is able to oxidize amore than 5 years, we have succeeded inenvironmental factor; the reaction of the Fe-Sof molecular mechanisms of metal catalyzed

wide variety of foreign compounds such as

cluster with reactive oxygen species andreactions. Followings are the current major

styrene, and ethylbenzene in the presence of amolecular mechanism of how VnfA transduce

projects in the group.

simple substrate trick, i.e., decoy molecules

sensing information into change in the

Introduction of peroxygenase and catalase

having a carboxylate group with a series oftranscription level of nitrogenase genes.

activities in myoglobin (Mb):

short alkyl-chain are misrecognised as

Physiological significance of the Fe-S cluster

substrates and P450 BS β starts to catalyze

in VnfA also retains to be solved.

Some structures of metalloenzymes designed by our group

生物無機化学研究室
Laboratory of Bioinorganic Chemistry

To understand the function-structure
relationship of hemoproteins and enzymes, weoxidation of non-natural substrates.

have been working hard to introduce activities

Construction of organometalo-enzymes:

properties

asanitrogenaseof P450, peroxidase, and catalase into

Ferritin (Fr) is an iron storage protein

myoglobin by designing its heme vicinity.

having a spherical structure. Instead of iron

Basic idea of our approach is that we could beions, we have introduced Pd ions in the apo-

able to construct myoglobin-based P-450,

ferritin cage and reduced them to prepare aperoxidase, and catalase if we reallyzero-valent palladium cluster and examined its◆ Current Articles ◆understand the enzymatic reaction mechanisms

catalytic reduction activity. The palladiumof the target heme enzymes. Finally, we haveclusters catalyzes size-selective olefin

successfully prepared a series of myoglobinhydrogenation because substrates must

1) H. Nakajima, N. Takatani, K. Yoshimitsu1, M. Itoh, S. Aono, Y. Takahashi, and Y. Watanabe,“The Role of the Fe-S Cluster in the Ssensory Domain of Nitrogenase Transcriptional Activator
VnfA from Azotobacter vinelandii,” FEBS J., 277, 817–832 (2010).

mutants exhibiting the targeted enzymaticDrs. T. Fukushima (left) and O. Shoji

2) N. Rosenberger, A. Studer, N. Takatani, H. Nakajima, and Y. Watanabe, “Azurin–Poly(Nisopropylacrylamide) Conjugates by Site-Directed Mutagenesis and their Thermosensitive
Behavior in Electron-TransferProcesses,” Angew. Chem. Int. Ed., 48, 1946-1949 (2009).
3) S. Abe, K. Hirata, T. Ueno, K. Morino, N. Shimizu, M. Yamamoto, M. Takata, E. Yashima, and Y.
Watanabe, “Polymerization of Phenylacetylene by Rhodium Complexes within a Discrete Space of
apo-Ferritin,” J. Am. Chem. Soc., 131, 6958–6960 (2009).

Professor WATANABE, Yoshihito
Associate Professor NAKAJIMA,Hiroshi
Assistant Professor SHOJI, Osami
Assistant Professor FUKUSHIMA, Takashi
http://bioinorg.chem.nagoya-u.ac.jp/

274) T. Ueno, M. Abe, K. Hirata, S. Abe, M. Suzuki, N. Shimizu, M. Yamamoto, M. Takata, and Y.
Watanabe, “Process of Accumulation of Metal Ions on the Interior Surface of apo-Ferritin: Crystal
Structures of a Series of apo-Ferritins Containing Variable Quantities of Pd(II) Ions,” J. Am.
Chem. Soc., 131, 5094-5100 (2009).
5) Y. Watanabe, H. Nakajima, and T. Ueno, “Reactivities of Oxo and peroxo Intermediates Studied by
Hemoprotein Mutants,” Acc. Chem. Res., 40, 554-562 (2007).
28

Organic Synthesis Groupby self-association, etc. By clarifying thematerial production. We are going to develop

reaction mechanism, we are going to make avarious catalysts according to the leading

useful database for investigation of new

guidelines which have been constituted on thereactions of new generation, which will bebasis of information we obtained from a series

made use of to synthesize organic compoundsof our studies concerning mechanism ofwith valuable performances.

catalytic reaction, such as bi-functional

We are going to advance level of our study

catalysts of donor-acceptor type, metastablestep by step in a spiral manner, repeating acoordination molecule, improvement ofcycle of development of catalyst, its

electronic and stereo-chemical supple-

application, and then clarification of reaction

methods from stoichiometric ones to catalytic

mentation in the transition state of reaction,mechanism.

ones in all the organic conversion.

unstabilization of complex of reaction products

Environmentally friendliness and potential

and catalyst, stabilization of reaction product

Image of catalysis for the production of amino acids.

有機合成化学グループ

drastic breakthrough of a new methodology ofusefulness of catalytic methods is excellent,
though actual efficiency must be evaluatedInvention or creation of useful materials

taking all the other factors into consideration.

having valuable properties and functions is

All the members of this laboratory are engaged

indispensable for human being in order toin germinal discovery of catalyst and its

survive in future, sustaining highly civilized

development, and also in catalytic synthesis ofsocieties. Organic chemistry constitutes a basis

useful organic compounds. And they try toof such techniques. Technology to supply

understand quantitatively the mechanism ofnecessary amounts of any necessary materials

catalytic reactions on the basis of our profoundat any time is totally required. Starting

information on the dependence of generalmaterials must be converted to target

applicability of substrates and catalytic

materials, whatever the amount may be, in an

efficiency upon reaction conditions. They also

environmentally friendly, safe, resource-saving

make use of intellectual database together with

as well as energy-saving method, and also withthelow E-factor (ratio of the amount of by-accumulated in the field of chemistry, andproducts to that of target material) and withcooperate with researchers of theoreticalhigh atomic efficiency. It must be prohibitedchemistry. Effective catalytic reaction is a

to supply materials to our society by means ofkind of treasury containing lots of basic

any compromising method even in case wherescientific information. Clarification of reaction

it gives us great economical advantages or it ismechanism is academically important, and atstill technologically pre-matured. This is thethe same time it sometimes gives rise to areason why we are expected to modify themethodology

which

have

been

◆ Current Articles ◆1) M. Kitamura, Y. Takenaka, T. Okuno, R. Holl, and B. Wünsch, “A New, Efficient and Direct
Preparation of TlTp and Related Complexes with TlBH4,” Eur. J. Inorg. Chem., 1188–1192 (2008).
2) R. Holl, M. Dykstra, M. Schneiders, R. Fröhlich, M. Kitamura, E.-U. Würthwein, and B. Wünsch,“Synthesis of 2,5-Diazabicyclo[2.2.2]octanes by Dieckmann Analogous Cyclization,” Aust. J. Chem.,
61, 914–919 (2008).
3) K. Tsuda, K. Miyata, T. Okuno, M. Yoshimura, S. Tanaka, and M. Kitamura, “Solvent-free One-pot
Synthesis of Thallium Complexes of Tp [BH(Pz)3]– (Pz = pyrazolate) and Its Derivatives,” Tetrahedron
Lett., 49, 2990–2993 (2008).
4) M. Tsukamoto and M. Kitamura, “Ether Synthesis by Substitution,” In Science of Synthesis, HoubenWeyl Methods of Molecular Transformations; C. J. Forsyth, Ed.; Georg Thieme Verlag: Stuttgart,
2008; Vol. 37 Ethers, Chapter 37.1.2.
5) S. Tanaka, H. Saburi, T. Hirakawa, T. Seki, and M. Kitamura, “Dehydrative Allylation of Alcohols andDeallylation of Allyl Ethers Catalyzed by [CpRu(CH3 CN) 3 ]PF 6 and 2-Pyridinecarboxylic Acid
Derivatives. Effect of π-Accepting Ability and COOH Acidity of Ligand on Reactivity,” Chem. Lett.,
38, 188–189 (2009).
6) S. Tanaka and M. Kitamura, “Ruthenium(1+), (η 5-2,4-cyclopentadien-1-yl)(η 3-2-propen-1-yl)(2quinolinecarboxylato-κN1,- κO2)-, Hexafluorophosphate(1–) (1:1),” e-EROS, (2009).
7) M. Tsukamoto and M. Kitamura, “Reduction by Homogeneous Catalysis or Biocatalysis. In Science ofSynthesis, Houben-Weyl Methods of Molecular Transformations,” H. Hiemstra, Ed., Thieme, Stuttgart,Vol. 48: Alkanes, Chapter 48.1.3.6.2 (2009).
8) T. Hirakawa, S. Tanaka, N. Usuki, H. Kanzaki, M. Kishimoto, and M. Kitamura, “A Magnetically
Separable Heterogeneous Deallylation Catalyst: [CpRu(η 3 -C 3 H 5 )(2-pyridinecarboxylato)]PF 6
Complex Supported on a Ferromagnetic Microsize Particle Fe3O4@SiO2,” Eur. J. Org. Chem., 6,
789–792 (2009).
9) S. Tanaka, T. Seki, and M. Kitamura, “Asymmetric Dehydrative Cyclization of ω-Hydroxy Allyl
Alcohols Catalyzed by Ruthenium Complexes,” Angew. Chem. Int. Ed., 48, 8948–8951 (2009).

10) Y. Ishibashi and M. Kitamura, “Solid-phase Synthesis of Protected α-Amino Phosphonic Acid

Professor KITAMURA, Masato

Oligomers,” Chem. Commun., 6985–6987 (2009).

http://www.os.rcms.nagoya-u.ac.jp

2930

water are applicable to other network-forming

the anomalies of these network-forming

materials such as silicon, silica, certain kind of

materials and give a unified explanation.

polymer, etc. It is also an our subject to findAssistant Professor MATSUMOTO, Masakazu
http://theochem.chem.nagoya-u.ac.jp/◆ Current Articles ◆1) M. Matsumoto, “Why does Water Expand when it Cools?,” Phys. Rev. Lett., 103, 017801(2009).

理論化学研究室
Laboratory of Theoretical Chemistry2) M. Matsumoto, A. Baba, and I. Ohmine, “Network Motif of Water,” AIP Conference
Proceedings, 982, (1): 219-222 (2008).

When you watch the earth from space, you

Our missions are to explore and explain

will find that its surface is covered with ocean,these anomalies and functionality of water in

ice fields at the pole, and clouds, i.e. the threeterms of molecular dynamics and mechanics.

phases of water. Water works as the blood for

We have been exploring the dynamics andthe ecological system by stabilizing the surface

structure of the hydrogen bond network oftemperature of the earth, dissolving nutritions,water and aqueous solutions by computer

and transporting materials.

simulations and finding hidden order and rules

Water has many anomalous properties, but

3) M. Matsumoto, A. Baba, and I. Ohmine, “Topological Building Blocks of Hydrogen Bond
Network in Water,” The Journal of Chemical Physics, 127, (13): 134504 (2007).
4) M. Matsumoto, “Relevance of Hydrogen Bond Definitions in Liquid Water,” The Journal ofChemical Physics, 126, (5): 054503 (2007).
5) M. Matsumoto, S. Saito, and I. Ohmine, “Molecular Dynamics Simulation of the Ice Nucleation
and Growth Process Leading to Water Freezing,” Nature, 416, (6879): 409-413 (2002).

behind the complicated transient network.

we are too familiar with water to be aware of

Our subjects of research are wide-ranging:its anomalies: water expands when it cools, ice

freezing dynamics of liquid water, proton

floats on the water, water has very high boilingtransfer reactions in water, ice, and aqueous

point for small molecular size, there are more

solutions,than 10 different ice crystal structures, etc.

crystallization of methane hydrate, cavitation

Life emerged and evolved in such an aqueous

in water, polyamorphism in supercooled liquid

environment by fully utilizing its anomalies.

water, reactivity of supercritical water,

Most of these anomalies originate not in thehydration of biomolecules, chemical reactions

property of single water molecule but in thein aqueous solutions, etc.

melting

dynamics

ofice,geometry and topology of the 3-dimensionally

Network-forming feature of water plays theinterconnected hydrogen bond network of

crucial role in all of these properties.

water.

Knowledges on the hydrogen bond network of

Associate Professor IRLE, Stephan
http://qc.chem.nagoya-u.ac.jp

量子化学グループ
Quantum Chemistry Group

Snapshots of crystallization process of water.

31

Our group is applying quantum chemical

metalated DNA (M-DNA) computing,methods in nanomaterials design by devisingnanobiosensors, transition-metal free organic

practical strategies aimed at overcoming thecatalyst) materials. In particular we employ

problem of dimensional complexity associatedcomputationally economical methods such aswith large molecular systems. Focus of ourdensity functional tight binding (DFTB),

efforts in "applied quantum chemical materials

resolution-of-identity (RI) DFT, RI-MP2, anddesign" is the theoretical exploration of

ONIOM, emphasizing the integrated molecularformation mechanisms, dynamics, reactions,orbital-molecular orbital (IMOMO) approach,spectroscopic properties, and functionality ofand facilitate ONIOM during molecular

nanocarbon (fullerenes, nanopeapods,

dynamics (ONIOM/MD) simulations. The

nanographenes, large-scale π -conjugated

IMOMO version of ONIOM has been widelyorganic polymers) and nanobio (DNA andused in the computational chemistry32

Associate Professor TAKAGI, Hideo D.
http://analysis.chem.nagoya-u.ac.jp/

QM/MD simulation following the "shrinking hot giant" road of dynamic fullerene self-assembly

community, and it can be expected that

relationship between structure and intended

ONIOM/MD will be of even greater use asfunctionality.

quantum chemical molecular dynamics

Physical Inorganic Chemistry Sub-Group

The term "nanobio materials design" isloosely used here and encompasses bothResearch projects of this laboratory arecoordination geometry around the Cu(II)concepts of "interface between the natural andrelated not only to the creation of newcomplexes is governed by the Symmetry

the man-made" as well as "synthetic biology

materials but to the highly intellectual activity

Rules and the Principle of the Least Motion.

formulate a feasible methodology tofor nanotechnology". The common factorof human beings, the pursuit of principles that

Such findings are important not only toemploy quantum chemical molecular structure

shared by high-temperature carbon chemistry

govern the Chemical/Natural phenomena. For

understand the efficiency of biological ET

methodology in high-dimensional, rugged

and low-temperature biochemistry is (besides

this purpose, Physical Inorganic Chemistry

reactions but also to design efficient artificial

PESs systems, combining DFTB- andtheir large molecular size domains) the

Laboratory at Nagoya University provides

catalysts.

ONIOM(DFT:DFTB)-based

QM/MD

occurance of PESs rough on the scale ofexcellent education program with the(2) Further understanding of Trans Influence

simulations followed by transition paththermal energies k b T introduced by theemphasis on physical theory and classicaland Trans Effect has been put forward: kinetic

sampling and high-level quantum chemical

breaking and formation of C-C covalent bonds

experimental techniques necessary to

studies of the thermal trans to cis

energy calculations and evaluate the quality of

in case of the former, and hydrogen-bond

implement precise chemical analyses such as

isomerizationsuch simulations,fluctuation in case of the latter chemistries.

equilibrium and kinetic measurements incobalt(III)/(II) and Ru(III)/Ru(II) complexes2)

For high-level reaction energetics as needed

solution.

with ligands containing phosphorous/sulfur(QM/MD)

simulations

have

becomeincreasingly popular in recent times.
More specifically, our research aims to1)

understand the principles of nanocarbon

reactionsofvariousand nanobio structure self-assembly,

for instance in the study of catalysis reaction

It should be noted that a strong background

donor atoms revealed that the reactions

3)

experimentallyenergy pathways we are using an extrapolationof Physical Inorganic Chemistry, especiallyproceed through the intramolecular twist

accessible properties (IR, Raman, UV spectra)

method similar to Curtiss' G4 method for both

symmetry considerations for chemicalmechanism accompanied by the ligand

for novel compounds and elucidate theground and electronically excited states.

processes on the basis of Group theory anddissociation of a B1g mode. It was also foundSpectroscopy enables us to analyze not onlythat the kinetic trans effect is governed by thethe geometries of chemical species including

combination of π -acidity of P-ligand and thethe reaction intermediates but also reaction

electron sponge effect of the spectator ligand.

pathways of metal complexes with different(3) Very slow solvent reorganization in Ionic

coordination geometries. The followings are

Liquids can be utilized for the separation of

only a few of the achievements born out of thecomplicated reaction steps: cis to transresearch projects conducted in this Laboratory.

isomerization of azobenzene derivatives(1) Factors that control biologically-

proceeds via a polrarized intermedeiate, which

important Gated electron transfer processes

was significantly retarded by the very slow

has been revealed: our intensive research of

reorganization process of the cationic andthe reactions involving simple copper (II)/(I)-anionic components of ionic liquids. Such a

polypyridine complexes revealed that theslow reorganization of cationic and anionichydrogen atom sputtering on the surface of graphite with defect and edge,” J. Nucl. Mater.,
390, 183-187 (2009).

Gating phenomenon is observed when (1) thecomponents can be used to separate a reaction

direct (concerted) ET between the ground state

step involving polarized intermediate by using

5) S. Irle, G. Zheng, Z. Wang, and K. Morokuma, “The C60 Formation Puzzle Solved: QM/MD

species is non-adiabatic, and (2) a low energy

ionic liquids as reaction media.

Simulations Reveal the Shrinking Hot Giant Road of the Dynamic Fullerene Self-Assembly
Mechanism,” feature paper in J. Phys. Chem. B, 110, 14531-14545 (2006).

CT band is provided by the “ uneven”

reliably

compute◆ Current Articles ◆1) Y. Ohta, A. J. Page, Y. Okamoto, S. Irle, and K. Morokuma, “Quantum Chemical Molecular

Dynamics Simulation of Single-Walled Carbon Nanotube Cap Nucleation on an Iron Particle,”
ACS Nano, 3, 3413-20 (2009).
2) E. Malolepsza, Y.-P. Lee, H. A. Witek, S. Irle, C.-F. Lin, and H.-M. Hsieh, “Comparison ofGeometric, Electronic, and Vibrational Properties for all Pentagon/Hexagon-Bearing Isomersof Fullerenes C38, C40, and C42,” Int. J. Quant. Chem., 109, 1999 (2009).
3) S. C. Xu, D. G. Musaev, S. Irle, and M. C. Lin, “Quantum Chemical Prediction of Reaction

Pathways and Rate Constants for Dissociative Adsorption of CO and CO2 on Defective
Graphite (0001) Surfaces,” J. Phys. Chem. C, 113, 18772-18777 (2009).
4) A. Ito, Y. Wang, S. Irle, K. Morokuma, and H. Nakamura, “Molecular dynamics simulation of

33

物理無機化学サブグループ

structural change, and (3) the change in the34

ガラス工作室
Glass Shop

Head Techical Staff NODA, Toshiaki
Techical Staff NATSUME, Hideko
Techical Staff OKAMOTO, Hisakazu
http/c60.chem.nagoya-u.ac.jp/~glass/index.html

Glass Shop belongs to the Technical Centerof Nagoya University and is fully equipped
for support conditions indispensable toeducation and research.
In recent years, more requests for large

Mechanism of the EC Reaction involving Ru(III)/(II)-dtc complexes

equipment and precision instruments havecome to the Shop. There have also been
many for making vacuum devices, cryogenic◆ Current Articles ◆1) Akira Hashimoto, Hiroshi Yamaguchi, Takayoshi Suzuki, Kazuo Kashiwabara, Masaaki

Kojima, and Hideo D. Takagi, “Preparation, Crystal Structures, and Spectroscopic and Redox
Properties of Nickel(II) Complexes Containing Phosphine-(A mine or Quinoline)-Type Hybrid
Ligands and a Nickel(I) Complex Bearing 8-(Diphenylphosphino)quinoline,” European Journalof Inorganic Chemistry, in press.
2) Kaori Aoki, Toshimitsu Goshima, Yohei Kozuka, Yukiko Kawamori, Noboru Ono, Yoshio

Hisaeda, Hideo D. Takagi, and Masahiko Inamo, “Electron transfer reaction of porphyrin andporphycene complexes of Cu(II) and Zn(II) in acetonitrile,” Dalton Trans., 119-125 (2009).
3) Chiaki Miyamato, Kazunori Suzuki, Satochi Iwatsuki, Masahiko Inamo, Hideo D. Takagi, andKoji Ishihara, “Kinetic Evidence for high reactivity of 3-nitrophenylboric acid compare to its
conhugate boronate ino in reactions with ethylene and propylene glycols,” Inorg. Chem., 47,
1417-1419 (2008).
4) Satoshi Iwatsuki, Shihoko Nakajima, Masahiko Inamo, Hideo D. Takagi, and Koji Ishihara,“Which Is Reactive in Alkaline Solution, Boronate Ion or Boronic Acid ? - Kinetic Evidence for
Reactive Trigonal Boronic Acid in Alkaline Solution -,” Inorg. Chem., 46, 354-356 (2007).
5) Sumitaka Itoh, Kyoko Noda, Ryouhei Yamane, Nobuyuki Kishikawa, and Hideo D. Takagi,“First Investigation at Elevated Pressures to Confirm Exact Nature of the Gated ElectronTransfer Systems: Volume Profiles of the Gated Reduction Reaction and Non-Gated Reverse2++
Oxidation Reaction Involving [Cu(dmp)2(solvent)] /[Cu(dmp)2] Couple (dmp = 2,9-dimethyl1,10-phenanthroline),” Inorg. Chem., 46, 1419-1425 (2007).

apparatuses, and solvent distillation
apparatuses. To design and make thishigh purity (patent publication 2000-126401)
was developed in our glass shop. The design

equipment effectively, it is important tounderstand the kind of research that is being
conducted within the department and toappreciate experimental design, particularly
in response to conditions of low temperatureand vacuum. Meeting these demands, such as
designing glass bellows, or how to get glassand metal to fit into each other, etc. hasrequired highly advanced technical skills andbroad knowledge of necessary skills. We are
fortunate in that we have this expertiseavailable to us. To meet these requests, alarge caliber glass lathe, a large electric
furnace, precision grinders (an outside
grinder, an inside grinder, and a diamondincorporates special glass flanges designed by
the staff, and the water content of anhydrous
solvents was reduced by 1/20 when compared
to another solvent distillation apparatus.
The evacuation apparatus usable also for
introducing inert gas (patent publication
2000-130124) is used in experiments that
require the use of substances that are unstablein air, and is indispensable for deaeration ofchemical samples and the introduction of inert
gas. The apparatus makes it easy to deareate
and introduce inert gas with a cock designed
for both vacuum and pressure work, and wasdeveloped by the staff.
Moreover, in conjunction with the Nano-

surface polishing machine) have beenacquired. The equipment and technical skills
are of the highest caliber in glass shops
nationwide.

Structured Materials Laboratory, the Shop

Associate Professor/ International Coordinator

By way of example, a solvent distillation

FISCHER, Berthold

apparatus capable of producing samples of

Associate Professor/ Manager
KATO, Kiyonori

G-COEオフィス
Global COE Officenanotubes" that has been submitted for apatent (patent application number 2002372004).
As previously mentioned, the Shop makes avariety of highly specialized glass equipmentthat is indispensable to the many fields ofchemistry. The Shop also offers technicalguidance in response to the demands fromlaboratories.

Drs.
K. Kiyonori (left)
and B. Fischer

The Shop received the award for technicalachievement from the Chemical Society ofJapan and a prize from the Japan Society for

To establish a vibrant global environment for education and research and foster young researchers
who can independently play an active role in international research, we promote our graduate

Analytical Chemistry for its considerable
achievements.

school to high caliber international graduate students, offer lectures to provide English literacy
education to our Japanese students, and collaborate with overseas graduate schools. The Global

developed a "method and apparatus for
manufacturing fullerene and carbon(from left)T. Noda, H. Okamoto, H. Natsume

COE Office supports these programs and projects, and takes care of international graduate students.
35

36

List of the Faculty Members
Department of Chemistry, Graduate School of Science
Furo, Chikusa, Nagoya 464-8602 Japan
http://www.chem.nagoya-u.ac.jp/

Reserch Group

Name

Phone

Ngagoya University

E-mailHigashiyama Campus

Organic Chemistry I

Professor

ITAMI, Kenichiro

052-788-6098

itami@mbox.chem.nagoya-u.ac.jp

Organic Chemistry II

Professor

YAMAGUCHI, Shigehiro

052-789-2291

yamaguchi@chem.nagoya-u.ac.jp

Biochemistry

Professor

ENDO, Toshiya

052-789-2490

endo@biochem.chem.nagoya-u.ac.jp

Associate Professor

YOSHIHISA, Tohru

052-789-2950

tyoshihi@biochem.chem.nagoya-u.ac.jp

Associate Professor

NISHIKAWA, Shuh-ichi

052-789-5909

shuh@biochem.chem.nagoya-u.ac.jp

Professor

NOYORI, Ryoji

052-789-2956

noyori@chem3.chem.nagoya-u.ac.jp

Associate Professor

SAITO, Susumu

052-789-5945

saito.susumu@f.mbox.nagoya-u.ac.jp

SHINOHARA, Hisanori052-789-2482

noris@cc.nagoya-u.ac.jp

KITAURA, Ryo

052-789-2477

kitaura@nano.chem.nagoya-u.ac.jp

HISHIKAWA, Akiyoshi

052-789-2494

hishi@mail.chem.nagoya-u.ac.jp

OUCHI, Yukio

052-789-2485

ohuchi@mat.chem.nagoya-u.ac.jp

AWAGA, Kunio

052-789-2487

awaga@mbox.chem.nagoya-u.ac.jp

MATSUSHITA, Michio M.

052-789-4552

matsushita.michio@e.mbox.nagoya-u.ac.jp

Noyori Laboratory

Nano-Structured Materials

Professor
Associate Professor

Photo-Physical Chemistry

Professor
Associate Professor

Theoretical Chemistry
Advanced Materials

Professor
Associate Professor

Analytical Chemistry

Professor

TANAKA, Kentaro

052-789-2940

kentaro@chem.nagoya-u.ac.jp

Inorganic Chemistry

Professor

TATSUMI, Kazuyuki

052-789-2474

i45100a@nucc.cc.nagoya-u.ac.jp

OHKI, Yasuhiro

052-789-2476

ohki@chem4.chem.nagoya-u.ac.jp

WATANABE, Yoshihito

052-789-3049

yoshi@nucc.cc.nagoya-u.ac.jp

Associate Professor

NAKAJIMA, Hiroshi

052-789-2953

hnakajima@mbox.chem.nagoya-u.ac.jp

Professor

KITAMURA, Masato052-789-2957

kitamura@os.rcms.nagoya-u.ac.jp

Associate Professor

Bioinorganic Chemistry

Organic Synthesis

Professor

Quantum Chemistry

Associate Professor

IRLE, Stephan052-747-6397

sirle@iar.nagoya-u.ac.jp

Physical Inorganic ChemistrySub-group

Associate Professor

TAKAGI, Hideo D.

052-789-5473

h.d.takagi@chem.nagoya-u.ac.jp

Associate Professor

FISCHER, Berthold052-747-6477

fischer@mbox.chem.nagoya-u.ac.jp

KATO, Kiyonori052-789-2954

kato.kiyonori@chem.nagoya-u.ac.jp

NODA, Toshiaki052-789-2492

noda@aqua.chem.nagoya-u.ac.jp

Technical Staff

NATSUME, Hideko

052-789-5497

deko@mbox.chem.nagoya-u.ac.jp

Technical Staff

OKAMOTO, Hisakazu

052-789-2492

okamoto@chem.nagoya-u.ac.jp

Administrator

MIYAZAKI, Yoshihito

052-789-5868

miyazaki.yoshihito@post.jimu.nagoya-u.ac.jp

Administrator

ARAYAMA, Hiroko

052-789-2961

arayama@mat.chem.nagoya-u.ac.jp

G-COE Office(International coordinator)

Associate Professor(Project manager)

Glass Shop

Chemistry Department Office37

Head Technical Staff

Nagoya University
Higashiyama Campus

38