s tar s taining

蛍光標識製品
蛍光標識製品

新世代の CAR-T 細胞検出ツール
新世代の部位特異的標識技術を採用
天然の構造と修飾を維持

均一性に優れ、ロット間の一貫性が高い
CAR-T 細胞検出専用に設計された製品

多彩な蛍光標識製品の中からお選びいただけます。

www.acrobiosystems.com

蛍光標識製品Star Staining

Star Staining は、ACROBiosystems が新世代の部位特異的標識技術によって開発した蛍光標識製品であり、"StarStandard" 品質基準のもと製造されています。
臨床試験での CAR-T 細胞の検出とモニタリング専用に設計された製品です。

Star-Staining 技術プラットフォーム

従来の化学的標識

新世代の部位特異的な標識

The labeling happens at the speciﬁc tag and far away from
active sites of proteins

Non-selective random labeling and aﬀect natural structureStar Staining の特長
天然の生物活性を維持する、新世代の部位特異的標識技術を採用

フローサイトメトリーによる検証時の特異度と感度が高い

遺伝子非導入 PBMC では非特異的結合を起こさない

均一性に優れ、ロット間の一貫性が高い多彩な蛍光標識製品を提供可能（FITC/PE/APC/Alexa Fluor ���/���/���）

当社の Star Staining 製品は、他社製品よりも強い蛍光信号を発します。

The activity of Alexa Fluor 647-Labeled Human Mesothelin (296-580),
His Tag (Cat. No. MSN-HA2H5) was higher than other Competitor.

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The activity of Alexa Fluor 488-Labeled Human Mesothelin (296-580),
His Tag (Cat. No. MSN-HA2H9) was higher than other Competitor.

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高純度Star Staining FITC 標識ヒト BCMA は 90% を超える高純度

FITC-Labeled Human BCMA, His Tag (Cat. No. BCA-HF2H3) onSDS-PAGE under reducing (R) condition. The gel was stained
overnight with Coomassie Blue. The purity of the protein is greaterthan 90%.

The purity of FITC-Labeled Human BCMA, His Tag (Cat. No. BCA-HF2H3) was more than 90% and themolecular weight of this protein is around 24-34 kDa veriﬁed by SEC-MALS.

高い生物活性
他社製品より高い結合活性

Binding activity of FITC-Labeled Human BCMA and CD19 protein from two diﬀerent vendors were evaluated by the FACS analysis. The result showedthat ACRO's Star Staining FITC-Labeled Human BCMA (Cat. No. BCA-HF2H3) and CD19 (Cat. No. CD9-HF2H3) protein have a much higher binding
activity than that of the other competitor.

遺伝子非導入 PBMC では非特異的結合を起こさない

Non-speciﬁc binding to non-transduced PBMCs between PE-Labeled Human BCMA Protein of Acro and competitor. 5e5 of non-transduced PBMCs werestained with PE -Labeled Human BCMA Protein and anti-CD3 antibody, washed and then analyzed with FACS. FITC signal was used to evaluate theexpression of CD3+ T cells in non-transduced PBMCs, and PE signal was used to evaluate the non-speciﬁc binding activity to non-transduced PBMCs.

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天然の生物活性を維持

結合の前後で高い結合特性を示すことが FACS および SPR により検証済み

Binding activity of the Human BCMA before and after FITC labeling was evaluated in the above FACS analysis. The result shows thatFITC-Labeled BCMA (Cat. No. BCA-HF2H3) and unconjugated Human BCMA have almost the same level of binding activity.

Binding aﬃnity of the Human BCMA before and after FITC labeling was evaluated in the above SPR analysis (Biacore T200). The resultshows that FITC-Labeled (Cat. No. BCA-HF2H3) and unconjugated Human BCMA, His Tag have almost the same level of aﬃnity.

ロット間の一貫性が高い

FITC / Alexa Fluor-555 / PE 標識ヒト BCMA タンパク質の結合活性は、FACS でロットごとに検証済み

Binding activity of diﬀerent lots of FITC-Labeled Human BCMA (Cat. No. BCA-HF2H3) , AF555-Labeled Human BCMA (Cat. No. BCA-HA2H6) and PE-Labeled
Human BCMA (Cat. No. BCA-HP2H7) against anti-BCMA CAR-293 cells was evaluated by ﬂow cytometry. The result shows very high batch-to-batch consistency.

高い安定性

PE-Labeled Human BCMA (Cat. No. BCA-HP2H7) and FITC-Labeled Human BCMA (Cat. No. BCA-HF2H3) at 25℃ for 48 hours and freeze-throwcycles are stable without performance reduction.

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製品リスト
蛍光標識

FITC

PE

APC

Alexa Fluor ���

Alexa Fluor ���

Alexa Fluor ���

分子分類コード

製品説明

BCMA

BCA-HF�H�

FITC-Labeled Human BCMA / TNFRSF�� Protein, His TagStar StainingCD��CD�-HF�H�

FITC-Labeled Human CD�� (��-���) Protein, His TagStar Staining

Mesothelin

MSN-HF�H�

FITC-Labeled Human Mesothelin / MSLN (���-���) Protein, His TagStar Staining

BCMABCA-HP�H�

PE-Labeled Human BCMA / TNFRSF�� Protein, His TagStar StainingCD��CD�-HP�H�PE-Labeled Human CD�� (��-���) Protein, His TagStar Staining

Mesothelin

MSN-HP�H�PE-Labeled Human Mesothelin / MSLN (���-���) Protein, His TagStar Staining

Siglec-�

SI�-HP�H�PE-Labeled Human Siglec-� / CD�� Protein, His TagStar Staining

BCMABCA-HA�H�

APC-Labeled Human BCMA / TNFRSF�� Protein, His TagStar StainingCD��CD�-HA�H�

APC-Labeled Human CD�� (��-���) Protein, His TagStar Staining

Mesothelin

MSN-HA�H�

APC-Labeled Human Mesothelin / MSLN (���-���) Protein, His TagStar Staining

BCMABCA-HA�H�

Alexa Fluor ���-Labeled Human BCMA / TNFRSF�� Protein, His TagStar StainingCD��CD�-HA�H�

Alexa Fluor ���-Labeled Human CD�� (��-���) Protein, His TagStar Staining

Her�HE�-HA�H�

Alexa Fluor ���-Labeled Human Her� / ErbB� Protein, His TagStar Staining

Mesothelin

MSN-HA�H�

Alexa Fluor ���-Labeled Human Mesothelin / MSLN (���-���) Protein, His TagStar Staining

Siglec-�CD�-HA�H�

Alexa Fluor ���-Labeled Human Siglec-� / CD�� Protein, His TagStar Staining

CD��CD�-HA�H�

Alexa Fluor ���-Labeled Human CD�� (��-���) Protein, His TagStar Staining

Her�HE�-HA�H�

Alexa Fluor ���-Labeled Human Her� / ErbB� Protein, His TagStar Staining

Mesothelin

MSN-HA�H�

Alexa Fluor ���-Labeled Human Mesothelin / MSLN (���-���) Protein, His TagStar Staining

Siglec-�

SI�-HA�H�

Alexa Fluor ���-Labeled Human Siglec-� / CD�� Protein, His TagStar Staining

BCMABCA-HA�H�

Alexa Fluor ���-Labeled Human BCMA / TNFRSF�� Protein, His TagStar StainingCD��CD�-HA�H�

Alexa Fluor ���-Labeled Human CD�� (��-���) Protein, His TagStar Staining

Her�HE�-HA�H�

Alexa Fluor ���-Labeled Human Her� / ErbB� Protein, His TagStar Staining

Mesothelin

MSN-HA�H�

Alexa Fluor ���-Labeled Human Mesothelin / MSLN (���-���) Protein, His TagStar Staining

Siglec-�

SI�-HA�H�

Alexa Fluor ���-Labeled Human Siglec-� / CD�� Protein, His TagStar Staining

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E m a i l : o r d e r @ a c r o bi o sy ste m s. c o m

その他の Star Staining 製品>>> Alexa Fluor ��� 標識
BCMAMesothelin

Glypican �CD���

CD���eMesothelin

Glypican �

NKG�DFAPCD��Mesothelin

Glypican �CD���

CD���eHER�

CD�

Siglec-�

CD��

EGF R

Glypican �

NKG�DFAP

Nectin-�CD��protein L

OX��

MUC-�

TSLP RCD���

CD���eHER�

Siglec-�

Siglec-�HER�

TSLP RCD��

Siglec-�>>> Alexa Fluor ��� 標識
BCMANectin-�CD��CD��>>> Alexa Fluor ��� 標識
BCMAHER�TSLP R>>> FITC 標識
Glypican �
EGFRVIIIprotein L>>> PE 標識
CD���>>> APC 標識
Glypican �PD-�

Siglec-�

GUCY�CCD���eOX��

Siglec-�

protein LSiglec-�

NKG�DHER�MUC-�

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PD-�

PD-�

FAP

Siglec-�

TSLP R05

OX��

OX��

Nectin-�Siglec-�

E m a i l : o r d e r @ a c r o bi o sy ste m s. c o m

MUC-�

MUC-�

CD��

PD-�

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