Quality Cancer Treatment in Resort Environment

PROTON THERAPY
BENEFITS● Reduced side effects● Better quality of life outcomes● Minimal disruption to daily life
● Proven to be effective among all age groups

Medipolis Medical Research InstituteMedipolis Proton Therapy and Research Center

What is Proton Therapy?
Proton beams are a flow of particles generated from hydrogen gas. By using anaccelerator, a synchrotron accelerating these particles to near the speed of light,
cancer can be accurately targeted. The proton beams have the ability to focus
and affect cancer lesions with minimal impact on surrounding muscle and tissues.
Thus it is possible to minimize detrimental effects on healthy tissues.
Established in 2011, Medipolis Proton Therapy and Research Center has treatedabout 2,150 patients as of June, 2017 with favorable results.
There are 2 kinds of radiation used for cancer treatment: photon and ion beams.
The photon beams are an electromagnetic wave used in traditional radiation
therapy such as X‐rays and gamma rays. Ion beam radiation uses hydrogen or
carbon atoms, and the radiation therapy using these particles is called particle
therapy. One of the characteristics of particle therapy is that the particle beam
has a physical property of energy emission called the Bragg peak, by which it caninflict lethal and concentrated damage on cancer cells.

What is Proton Therapy?
Difference between X‐ray and proton beam treatments
While X‐ray delivers radiation not only to the tumor but also to healthy organs
and tissues around the tumor, proton beams can release its maximum energy at
the tumor and stop there. Therefore it can minimize the effect on healthyorgans and tissues.

What happens in the body after the irradiation with proton
beams?
When the body is irradiated with a proton beam, the beam reaches a tumor witha minimal effect on surrounding normal tissues. It then attacks DNA in the coreof the cancer cells. The cancer cells damaged by the proton beam are unable toreproduce which then followed by a gradual disappearance of the tumor.

Some Treatment Results
Early Stage Lung Cancer：Area ofradiation pneumonitis by proton
beams that we see after thetreatment is less than that ofphoton. Therefore it may bepossible to treat lung cancerpatients with poor lung condition
that cannot be treated by photon
radiation therapy.
Hepatocellular Carcinoma: Japanleads the proton therapy of HCC.
90% has been successfully treatedregardless of the size of tumor,
and recurrent tumors in the liver
can also be treated.

Prostate Cancer：Primary lesion
with T1c‐T4N0M0 is applicable.
The benefits are; being able topreserve sexual function withnone or lighter incontinencecompared to the other treatments.
Prostate cancer is the mostcommon disease for treatment
with particle therapy in Japan.
Rossi CJ, Slater JD, et al. Particle beam radiation therapy in prostate cancer: Is there anadvantage? Sem. Radiat. Oncol. 1998; Vol.8, Issue2, 115‐123.

Treatable Cancers
Proton therapy is highly effective when the tumor is solid, well‐defined,localized, and non‐metastasized. MPTRC provides proton therapy forcancers of the prostate, lung, liver, bile duct, pancreas, head and neck,esophagus and more. Meanwhile, proton therapy offers no benefit ingastrointestinal and blood cancers.
Length of treatment depends on the type, size, and position of thecancer as you can see the table below (it includes medical examinations,creation of a treatment plan and a simulation of the treatment.)

Esophagus
Lung and metastasis(up to three tumors)

Skull base

Head and neckBile duct
Mediastinum
Liver and metastasis(up to three tumors)

KidneyPancreas
Bone and soft
tissueProstate

Recurrence after
surgery for rectal
cancerOther localized cancers include limited lymph
node metastases

Treatment Period and Cost

Treatment Cost: ¥6,000,000/one area (1 US dollar = approximately ¥109‐
112, reference: as of 2017 Foreign Exchange Quotations of Mizuho Bank)

The treatment cost is inclusive of administration fees. Please note, thatthe cost above does not include travel costs or living expenses. If you
would like further information such as the payment method anddetailed estimated fees, please contact us by e‐mail.

Resort Environment
The facility includes a resort hotel called Ibusuki Bay Hills Hotel & Spa which
offers various kinds of spa treatments including hot sand spa that is specificallyfamous in Ibusuki, swimming pool, gym, soccer ground, tennis court, and hiking
course with 900 acres of land. The hotel also offers French restaurant, Japaneserestaurant, and Teppanyaki.

Joint Commission International (JCI) Accredited
MPTRC is the world’s first proton therapy specializedorganization, JCI, a globally recognized accreditation organization
which evaluates the patient safety and quality of health careorganizations.
The Joint Commission (JC) has accredited over 21,000 healthcareorganizations in the United States, and JCI, international versionof JC has accredited 1013 organizations in 69 countries, 25 ofwhich are in Japan (as of march 3, 2018).
We will continue to improve our quality of cancer treatment andenhance it for patient safety.

Access●●TokyoMedipolis

By airplane• 7hrs from Singapore to Tokyo and 2hrs from Tokyo to Kagoshima• 3hrs and 15mins from Hong Kong to Kagoshima• 2hrs from Shanghai to Kagoshima• 1hr and 35mins from Seoul to Kagoshima
By airport shuttle bus
95mins from Kagoshima Airport to JR Ibusuki Station and 15mins from JR Ibusuki Station to MPTRC by taxi

Contact Us
If you have any questions , please do not hesitate to contact us. We will be happy to help you.
Phone : +81‐993‐24‐3456 Weekdays from 8:00 to 16:30 JST E‐Mail : mptrc@medipolis.org
Location : Medipolis Proton Therapy and Research Center, 4423 Higashikata, Ibusuki, Kagoshima, 891‐0304