MYUNI_MRS.doc

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Men who had surgery for rectal and prostate cancer aroundage 60 were more than twice as likely to have cognitive
impairments four years later than men who were matched forage and health and received standard treatment. Men withcancer of the prostate who had surgery had the greatest
increase in cognitive impairments. The findings suggest thatmen who had surgery to treat prostate cancer should bemonitored for cognitive changes. Surgery for the rectal
cancer didn’t appear to affect cognitive function. Results ofthis study have been published in JAMA Oncology. A
commentary is also published with the findings. It’s known
that patients with cancer often experience impairments incognitive functions such as memory, thinking, and reasoning.
It’s also known that certain forms of cancer treatment canaffect cognition. In this study of men with rectal and prostatecancer who had the option of receiving either standard
treatments or surgery, researchers focused on whether thesepatients had cognitive impairments following treatment. The
researchers focused on cognitive impairments that could
occur with treatment for these types of cancer, such aschanges in intellectual abilities, memory, and reasoning

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abilities. Possible explanation for increased risk Researchers
theorized that a possible explanation for the increased risk ofcognitive impairments was that older adults with cancer who
had surgery were more likely to have heart problems as wellas poorer overall health, both of which can affect memory.
To account for this, the researchers used healthy aging
models to account for age. They compared how well thepatients did on memory tests with how well people who werematched for age and health did on the same tests. At fouryears after their cancer diagnosis, researchers observed thatolder men with rectal cancer who had surgery were much
more likely to have impairments in reasoning (2.8 times morelikely) and memory (1.5 times more likely) than those who
received the standard treatment. It’s important to note thatneither of the groups had any impairment in reasoning prior
to treatment. The second group, those with prostate cancer,
had similar impairments in reasoning and memory but less
impairment in the way of reasoning. These findings suggestthat surgery for rectal cancer, in addition to known negative
effects such as physical changes, can pose a significant risk
to cognitive function. TheDownload
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MYUNIMRSdoc