ŷƖƊƺƞƲƱƎƙǆžŻ࢘௞๐ӁÎ්‫ࡽح‬૝‫ؘذ‬ฏ๐‫߳ޞ‬ӁÏ૴ࣦഄГϥЋӁƀƾƣſ૜ƾƐĀÜ૴ࣦഄГ‫༹ݩ‬Ӂʑƽƿॄ຤Ɗǁǀ๐‫߳ޞ‬ǇƶƋƌƛʑÝƣƉϚఊĀȒǡǗȆǵÀǠȉțǰƠƙŹƛ‫ܯ‬ŽƛƴƳƐǈƀ­á ƒƣľ á

Vol.9@>>@ABCDĀ૴ࣦഄГ‫༹ݩ‬Ӂә‫ޅ‬ƣſ૜ƾƐ|Ìb|ådíd®´µ|Ìb¿}díd®Y÷ì0

&K5'

¨ëQ

(

#$!5|}b|ådíd®Q"#ð¹b¿}díd®Q$%ì&'(!)*+


&K5'

C¨â,Y÷ì-$.`J!"

|Ì(+<0£/5%0Q1â)2,DEYC+<34Ê50`S6D<78<9C¦=50ªS7C:5&¦'5;00<«'>?+<!.@A>0B?¤A>,-ÊC

6DEM-&
J&'

FGH0:I57Iª7`S«¬?@&&¦K&(¨âY÷ìQ1â)2)«'=0KìLC
%ì0MëN<0´O¦5$.`Jì0RëSTë=0KìLC´&`X£

U@C('Kh5&¼ª5Y5'(Zo[2\]0´^5¨ëY÷ìQ,V!`Jw

b5[`S?@ªK&J&'

aíùbcdefb®QlA>´&
C¦7&DE7Cbcdefb®,-vw12Vx`Ju_É`_-&&´'(tu_É`_
&"5Q+<=>mA>´&n(5r57IaíùPQV!`Jw

tb57fJ7I7&&V_7uAyE7(¤Pbz7Ü0{65bC¦((DEopqrsCtu0V&sC+<nrR7&C')«'0&ijrI+<`Stu`JKD0b5k3
-&rPQ%MëìKëì0!)VWaíùbcdefb®0gh5
Cv

+<0£/&7&&|}C5'&w

`S-(¨ëY÷ìCQ&r~ºaíùbcdefb®
0b5 &"r-& ª7`S?@ ªK&J&' ('Kaíùbcdefb®0b5hf & rK&H6b0I57Iýþ 5 ª7`SÊC¦J?@ &' (`S ¡5 DE0f
C¦ K£K+<C¦0&5;5 ª'RSr( ĀȒǡǗȆǵÀǠȉțǰƠƙŹƛ‫ܯ‬ŽƛƴƳƐǈƀ­á ƒƣľ á&'(!")*+,-)./¿¿MbdñdThi,ùCLMNH—D<áâ|C—0&º75CABlCV·5KDEFG9_`J'5K('K·QFG90fMb|ädefCdT+<ìµdT+<ìp5,tuRS5ì005dT
D<ìp5Q,+<rI5ì00E5é&C¿¿Mb|ådefdÝíUl®CQ+<=0&'&'(

DEFGC(,TMbKd±²³¿ d¾tu`JKltuRS0fefKm5ì057&''Z+5

J0d5KNH·5KFHCQgh5¡¢5&Z+FGV·5'5K(¨ëV&Kgh£EYtuRSCv

K¤¥I¦§¨©+ª~áâe«CQ¬r7ùàYáâã
5&K

J&

+Cv

&+<5xðC­®

¯Tº7°±n²³tux|xCvK¤¥I¦+<«uº7ªC2´ð%¦5ì0!¥7rK«Üº7tuµ@I0¶»Z+·¥7°±c¸¹n²ºCvK»+<5¯Tºo»CQv'RS(—©¼—001231456789:#;123145<=>:?
¨ë9_0¦rf.ÉÊ0+no34½¦D¾-Cv

!-¦vIK£,?@`RIJ'5K(DEFGqr¿jrI²³ÙØ¶í|YÝÞßÙØÀÁª®Q`J&CÂÀYrÃ@`JÅÆQC¦&'(J'C)*+0Ä#fÇ&ÜÈ|¶í|YÝÞß|ÀÁª®6È@0!

É"Ê'5&?@'5

K(¤C¨ë²³ÙØ¶rI|¶6È@0!vK+<Ë ¥!"½¦7r0?@ªáȒǡǗȆǵÀǠȉțǰƠƙŹƛ‫ܯ‬ŽƛƴƳƐǈƀ­ ƒƣľáK&J&'('¦QÝÞß*+./-&J&'úû´`I&5´¦K&(ü²³ÙØ¶|¶ßýþßÞ'QÝÞß*+ßýþßÞ'¯WCv
Cv|®Ð¿®²³ÙØ¶|¶7&IJ&+)»Ì®0I°(üÝÞßàYáâQ.ª~áâe«CQ¥¦r7ùxðC­®àYáâã°IJ&(7¥@}´´fÝÞßàYáâùxoÎ|0IûQK£mnopg)
qrs
ti>
j>
@>

(µg/ml) =>ÕÚÕ%0&KC«`J(I

ª~àYáâe«CQ¬r7ùàYáâ­®!

x

xC

=@

jik

l9

uvwxyz{|z{}~Q5)uvwqrst)

(ü²³ÙØ¶Á'J¶"+0?#R¦*+x0$

6È@0!å&àYáâCÕÞÑ`J&¦7%&ÝÞßàïwMvYáâùx5ùû0I(H@@}´´fÕÚÕ%'(]üº.@`Jx}¶íÌîÛ|.ÌîÙåàYáâ¿ä¶í|ä.|ÛîØÌµ  À,®!

&QYìÎ}V|ä®Ðå®/£IJ(|ÙÙØdT*Å5K0ÞZ1CQ²³ÙØ¶rI|26È@0!KÛ|ÅÆYYìÎ}»345
IJKÅÆcÅÆàYáâÍ@Å`JQàYáâ!º5H/£&KÌØÅÆYàYáâ!/£IJKÅÆcÅÆCvK9v
6}®(

7&Q&@²³rI|¶6È@ÝÞßàYáâ!v&RdxÔÀ)*äîåÛÀ + d| ¿ÔÀ)*¿îØ¿µ  À,0&KS-àCQàYáâ|ä µ  À,ÜùÀ + d®

CQ(0Þ²³ÙØ¶u|¶2678&&ÊvK( áȒǡǗȆǵÀǠȉțǰƠƙŹƛ‫ܯ‬ŽƛƴƳƐǈƀ­ ƒƣľáÌ²³ÙØ¶rI|¶6

È@QÝÞßàYáâ0Í@5àYáâã6Î}
ð»ÉÊÏ&ÐÑÒÓyECÕÞÑ`J&àYáâã56'(.÷ø£EáâÔe«CÖvw6×ðkØãÙ5&Eºv&»QÚD!yEv

?@(EF¤G?)HIC6È@0!ÛÜ-&Ý&J&'?@ª'5K(\?7Jª(J1231456789:KLMN)OPQRSTÞÞQß£Du5ù¶*+5ùx0«áâ5xàYáâà©|ãä(ÝÞßàYáâå&.ùQÉÊÏ&ÐÑÒÓyE7xp5

0æ5àYáâå&´"(UMNVW)XYZRST*+0d`Jçè0æ5Kéæê0u5²³ÙØ¶&ãäìÎ}´µYìÎ}0V|í«YìÎ}J¥JIïw7(¤YQÝÞß«ëº7YàYáâ-&éæ(¤JÎ}V|5Kîß£D95([\]^_NVW)XYZRSTîðð5&78<+©ÉÊFñ034&K#"

CYìÎ}0ò6rVC¦[\0çp¡ïw7K£67(`ab'(!"cdefghltuRS0V!5&&ÅÆCQ²³ÙØ¶0d5p5óféæê0ô5éæ()ÜõöZ+méæê0u5tuRS«¬:5 ÷(+<*+6È@øùº ¥DáȒǡǗȆǵÀǠȉțǰƠƙŹƛ‫ܯ‬ŽƛƴƳƐǈƀ­ ƒƣľá!"#$%

7890:;&'()*+,-./0123456+<=>#?@'(ABCDEFGCH"7IJKLMN0OP5Q7'RS(TUV!WXYZ+FG[\]^9_7`J'5K(abcdefgdhiQjklmCnopqSrSZ+FGstuCv qf&JS0w"Z+57rKrxyz5 &K{-&_'Kab|}dgdhiQ~lC
7fJ7I7&9|0Z+5

|x0Z+5cd

&Z+FG9_`J'5K(
5"+Q

"¡0¢£'5K(¤5I7"7F0YFCvK`S[\]^0¥¦§¨©ª7`S«¬?@7Z+FG§&¦K&¡­&'5K(|® dT*¯°±²³´µ|¶·¸¹º)»M¼½¾¿® dT*¯°±|VÀvKÁÂÃÄÅÆÇ´&}® dT*¯°±²³rI|¶6È@Á¾ÉÊ´Ë&¾Ì® ÍkÎÏÐÑÒÓÔÕÖ×Ð|ØÒ¿ØÙÚ¿ÛÌÐ¿±²³rI|*+6È@Ü´fÝÞßàYáâã¾

ä® dT*¯°±²³rI|6È@å® æçèéÐÑÒê}¿ëdTÉÊ´Ë&¾

SrS¹ìí|ÙÙÛî|îÙÚ|î|®±²³rI|+ïàYáâð¾
Ø® ñòóôÐÑÒD¹võªÐê|ØöÐêcUÐä|¿Úä|ÌÐ|ÙØÛ±÷ø´fàúYáâÝÞßùû¾൴࢒«௞๐Ӂ૴ࣦഄГϥЋӁ‫ࡽح‬༡‫ޒ‬ഄГ්‫߲ࡽح‬ແਿ݉ໝϽǣțǧÀߎ೫ҍԆ‫ࣄؐࠔުݗ‬യ੠ഄГ‫ึ½ݴ‬ഄГગ༸঩ผϺझ༸٢ૡஎೢ܎‫ึ½ݴ‬ຈ්߰‫߲ࡽح‬ແใߨഄГଚແφҀ૴ѭഄГ݃໫Ӂ ݃‫૴ڔ‬ѭഄГƴƞƿࢗ࠘ ܶ‫܀׾‬বഄГTüýþÊQÎsÙ¿¿Úäåå{'C´R`&( ൲ߑ լ௅Ϻ‫ܢ‬ຕॏ๡уࠟм๡у๴E  x