Inhibitor and Fluorogenic Substrates for SARS-CoV-2 Proteases
CodeCompound3253-v

Ac-Abu-D-Tyr-Leu-Gln-VS		
Vial
1 mg
25,000New

4-(Acetyl-L-α-aminobutyroyl-D-tyrosyl-L-leucyl)amino-6-(methylsulfonyl)hex-5E enamide-20℃(M.W. 609.73)

Price:Yen

C28H43N5O8S

Inhibitor for SARS-CoV-2 Main Protease (Mpro, a.k.a. 3CLpro)
1) W. Rut, K. Groborz, L. Zhang, X. Sun, M. Zmudzinski, B. Pawlik, X. Wang, D. Jochmans, J. Neyts,
W.Młynarski, R. Hilgenfeld, and M. Drag, Nat. Chem. Biol., in press. (Original)

3249-vNew-20℃

Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-LysMet-Glu(Edans)-NH2
Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-LysMet-Glu(Edans)-NH2

Vial

1 mg

50,000(Trifluoroacetate Form)(M.W. 2080.4)

C95H142N26O23S2

Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Main Protease (Mpro)
1) C.-J. Kuo, Y.-H. Chi, J.T.-A. Hsu, and P.-H. Liang, Biochem. Biophys. Res. Commun., 318, 862 (2004).
(Substrate for SARS-CoV Main Protease)2) L. Zhang, D. Lin, X. Sun, U. Curth, C. Drosten, L. Sauerhering, S. Becker, K. Rox, and R. Hilgenfeld,
Science, 368, 409 (2020). (Substrate for SARS-CoV-2 Main Protease)3250-v

Ac-Abu-Tle-Leu-Gln-MCA		

New

Acetyl-L-α-aminobutyroyl-L-tert-leucyl-L-leucyl-L-glutamineα-(4-methylcoumaryl-7-amide)-20℃(M.W. 656.77)

Vial

1 mg

10,000C33H48N6O8Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Mpro (a.k.a. 3CLpro)
1) W. Rut, K. Groborz, L. Zhang, X. Sun, M. Zmudzinski, B. Pawlik, X. Wang, D. Jochmans, J. Neyts,
W. Młynarski, R. Hilgenfeld, and M. Drag, Nat. Chem. Biol., in press. (Original: ACC Version)

3251-v

Ac-Thz-Tle-Leu-Gln-MCA		

New

Acetyl-L-thioprolyl-L-tert-leucyl-L-leucyl-L-glutamineα-(4-methylcoumaryl-7-amide)-20℃(M.W. 686.82)

Vial

1 mg

10,000C33H46N6O8S

Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Mpro (a.k.a. 3CLpro)
1) W. Rut, K. Groborz, L. Zhang, X. Sun, M. Zmudzinski, B. Pawlik, X. Wang, D. Jochmans, J. Neyts,
W. Młynarski, R. Hilgenfeld, and M. Drag, Nat. Chem. Biol., in press. (Original: ACC Version)

3252-v

Z-Arg-Leu-Arg-Gly-Gly-MCA 		New

Benzyloxycarbonyl-L-arginyl-L-leucyl-L-arginylglycylglycine
4-methylcoumaryl-7-amide-20℃(M.W. 848.95)

Vial

1 mg

10,000C40H56N12O9

Fluorogenic Substrate for Isopeptidase T and Coronavirus (CoV) PLpro
1) R.L. Stein, Z.J. Chen, and F. Melandri, Biochemistry, 34, 12616 (1995). (Original; Substrate for Isopeptidase T)
2) Y.M. Baez-Santos, A.M. Mielech, X. Deng, S. Baker, and A.D. Mesecar, J. Virol., 88, 12511 (2014).
(Substrate for CoV PLpro)
3) E. Smith, M.E. Davis-Gardner, R.D. Garcia-Ordonez, T.-T.Nguyen, M. Hull, E. Chen, P. Baillargeon, L. Scampavia,
T.Strutzenberg, P. Griffin, M. Farzan, and T.P. Spicer, SLASDiscov., (2020). (Substrate for SARS-CoV-2 PLpro
Enzymatic Assay)
4) A.K. Ghosh, M. Brindisi, D. Shahabi, M.E. Chapman, and A.D. Mesecar, ChemMedChem, 15, 907 (2020). (Review)－1－

APP and Aβ-Related Peptides
Code

Compound4518-v

APP669-711		
Vial
Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-ValHis-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-AsnLys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

New
-20℃

Price:Yen
0.5 mg30,000(Trifluoroacetate Form)(M.W. 4688.3)

C210H325N57O61S2A Factor of Plasma Biomarker for Cerebral Amyloid
1) N. Kaneko, R. Yamamoto, T. Sato, and K. Tanaka, Proc. Jpn. Acad. B, 90, 104 (2014). (Identification in Plasma)2) N. Kaneko, A. Nakamura, Y. Washimi, T. Kato, T. Sakurai, Y. Arahata, M. Bundo, A. Takeda, S. Niida,
K. Ito, K. Toba, K. Tanaka, and K. Yanagisawa, Proc. Jpn. Acad. B, 90, 353 (2014).
(Correlation between APP669-711/Aβ 1-42 in Plasma and Cerebral Amyloid Deposition)3) A. Nakamura, N. Kaneko, V.L. Villemagne, T. Kato, J. Doecke, V. Dore, C. Fowler, Q.X. Li, R. Martins, C. Rowe,T. Tomita, K. Matsuzaki, K. Ishii, K. Ishii, Y. Arahata, S. Iwamoto, K. Ito, K. Tanaka, C.L. Masters,
and K. Yanagisawa, Nature(London), 554, 249 (2018).
(APP669-711/Aβ 1-42 in Plasma as a Biomarker for Alzheimer's Disease)3423-sNew-20℃

6-TAMRA-Amyloid β-Protein (Human, 1-40) 		
6-TAMRA-Aβ1-40
6-TAMRA-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-ValHis-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-SerAsn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
6-TAMRA:6-Carboxytetramethylrhodamine

Vial

0.1 mg30,000Amyloid β-Protein (Human, 1-40) (Scrambled)		
Vial
Scrambled β-Amyloid (1-40)
Ala-Glu-Gly-Asp-Ser-His-Val-Leu-Lys-Glu-Gly-Ala-Tyr-Met-GluIle-Phe-Asp-Val-Gln-Gly-His-Val-Phe-Gly-Gly-Lys-Ile-Phe-ArgVal-Val-Asp-Leu-Gly-Ser-His-Asn-Val-Ala

0.1 mg9,000

0.1 mg18,000(Trifluoroacetate Form)(M.W. 4742.2)

4513-sNew-20℃

C219H315N55O62S1(Trifluoroacetate Form)(M.W. 4329.8)

C194H295N53O58S

Control Peptide for Amyloid β -Protein (Human, 1-40)
4514-sNew-20℃

Amyloid β-Protein (Human, 1-42) (Scrambled)		
Vial
Scrambled β-Amyloid (1-42)
Ala-Ile-Ala-Glu-Gly-Asp-Ser-His-Val-Leu-Lys-Glu-Gly-Ala-TyrMet-Glu-Ile-Phe-Asp-Val-Gln-Gly-His-Val-Phe-Gly-Gly-Lys-IlePhe-Arg-Val-Val-Asp-Leu-Gly-Ser-His-Asn-Val-Ala(Trifluoroacetate Form)(M.W. 4514.0)

C203H311N55O60S

Control Peptide for Amyloid β -Protein (Human, 1-42)－2－Biologically Active Peptides
Code

Compound4515-v

AIP-I		Autoinducing Peptide-I, AIP1, Agr D1 thiolactone
Tyr-Ser-Thr-Cys-Asp-Phe-Ile-Met

New
-20℃

Price:Yen
Vial

0.5 mg20,000(Thioester bond between Cys4-Met8)(Trifluoroacetate Form)(M.W. 961.11)

C43H60N8O13S2

A Peptide Modulator of Quorum Sensing in Staphylococcus spp.
1) G.Y. Ji, R.C. Beavis, and R.P. Novick, Proc. Natl. Acad. Sci. U. S. A., 92, 12055 (1995). (Original/Bioactivity)
2) G. Ji, R. Beavis, and R.P. Novick, Science, 276, 2027 (1997). (Bioactivity)
3) P. Mayville, G.Y. Ji, R. Beavis, H.M. Yang, M. Goger, R.P. Novick, and T.W. Muir,
Proc. Natl. Acad. Sci. U. S. A., 96, 1218 (1999). (Chem. Synthesis)
4) B. Wang, and T.W. Muir, Cell Chem. Biol., 23, 214 (2016). (Review)

4516-v
New-20℃

AIP-II		
Vial
0.5 mg20,000Autoinducing Peptide-II, AIP2
Gly-Val-Asn-Ala-Cys-Ser-Ser-Leu-Phe(Thioester bond between Cys5-Phe9)(Trifluoroacetate Form)(M.W. 878.99)

C38H58N10O12S

A Peptide Modulator of Quorum Sensing in Staphylococcus spp.
1) G. Ji, R. Beavis, and R.P. Novick, Science, 276, 2027 (1997). (Original/Bioactivity)
2) P. Mayville, G.Y. Ji, R. Beavis, H.M. Yang, M. Goger, R.P. Novick, and T.W. Muir,
Proc. Natl. Acad. Sci. U. S. A., 96, 1218 (1999). (Chem. Synthesis)
3) B. Wang, and T.W. Muir, Cell Chem. Biol., 23, 214 (2016). (Review)

4517-v
New-20℃

AIP-III		
Vial
0.5 mg20,000Autoinducing Peptide-III, AIP3
Ile-Asn-Cys-Asp-Phe-Leu-Leu(Thioester bond between Cys3-Leu7)(Trifluoroacetate Form)(M.W. 818.98)

C38H58N8O10S

An Apparent Peptide Modulator of Quorum Sensing in Staphylococcus spp.
1) G. Ji, R. Beavis, and R.P. Novick, Science, 276, 2027 (1997). (Initially Reported Octapeptide)2) G.J. Lyon, J.S. Wright, T.W. Muir, and R.P. Novick, Biochemistry, 41, 10095 (2002).
(Structure Renovation/Bioactivity/Chem. Synthesis)
3) B. Wang, and T.W. Muir, Cell Chem. Biol., 23, 214 (2016). (Review)4503-sNew-20℃

Snakin-1		Vial
0.1 mg30,000SN1, GSL1
Gly-Ser-Asn-Phe-Cys-Asp-Ser-Lys-Cys-Lys-Leu-Arg-Cys-Ser-LysAla-Gly-Leu-Ala-Asp-Arg-Cys-Leu-Lys-Tyr-Cys-Gly-Ile-Cys-CysGlu-Glu-Cys-Lys-Cys-Val-Pro-Ser-Gly-Thr-Tyr-Gly-Asn-Lys-HisGlu-Cys-Pro-Cys-Tyr-Arg-Asp-Lys-Lys-Asn-Ser-Lys-Gly-Lys-SerLys-Cys-Pro(Disulfide bonds between Cys5-Cys30,Cys9-Cys26,Cys13-Cys22,Cys29-Cys62,Cys33-Cys49 and Cys35-Cys47)(M.W. 6922.0)

C285H454N88O89S12

Antimicrobial Peptide
1) A. Segura, M. Moreno, F. Madueno, A. Molina, and F. Garcia-Olmedo, Mol. Plant-Microbe Interact., 12, 16 (1999).
(Original)
2) P.W.R. Harris, S.-H. Yang, A. Molina, G. Lopez, M. Middleditch, and M.A. Brimble, Chem. Eur. J., 20, 5102 (2014).
(Chem. Synthesis)
3) H. Yeung, C.J. Squire, Y. Yosaatmadja, S. Panjikar, G. Lopez, A. Molina, E.N. Baker, P.W. Harris,and M.A. Brimble, Angew. Chem. Int. Ed., 55, 7930 (2016). (S-S Bond)4) M.R. Kuddus, F. Rumi, M. Tsutsumi, R. Takahashi, M. Yamano, M. Kamiya, T. Kikukawa, M. Demura,and T. Aizawa, Protein Expr. Purif., 122, 15 (2016). (Rec. Synthesis)5) H. Senechal, J. Santrucek, M. Melcova, P. Svoboda, J. Zidkova, D. Charpin, L. Guilloux, Y. Shahali, M.A. Selva,
R. Couderc, T. Aizawa, and P. Poncet, J. Allergy Clin. Immunol., 141, 411 (2018). (Pharmacol.)6) M. Oliveira-Lima, A.M. Benko-Iseppon, J.R.C.F. Neto, S. Rodriguez-Decuadro, E.A. Kido, S. Crovella,
and V. Pandolfi, Curr. Protein Pept. Sci., 18, 368 (2017). (Review)－3－

Peptide Tools
Code

Compound3413-v

Val-His-Leu-Thr-Pro-Glu		New

L-Valyl-L-histidyl-L-leucyl-L-threonyl-L-prolyl-L-glutamic acid

-20℃

Price:Yen
Vial

0.5 mg3,000(Trifluoroacetate Form)(M.W. 694.78)

C31H50N8O10

N-Terminal Hexapeptide of Hb β -Chain
1) U. Kobold, J.O. Jeppsson, T. Duelffer, A. Finke, W. Hoelzel, and K. Miedema, Clin. Chem., 43, 1944 (1997).

New

Val-His-[D7]Leu-Thr-Pro-Glu		
Val-His-*Leu-Thr-Pro-Glu-20℃*Leu: Leucine-(isopropyl-d7)

3414-v

Vial

50 μg

10,000(Trifluoroacetate Form)(M.W. 701.82)

C31H43D7N8O10

Stable Isotope-Labeled N-Terminal Hexapeptide of Hb β -Chain
1) U. Kobold, J.O. Jeppsson, T. Duelffer, A. Finke, W. Hoelzel, and K. Miedema, Clin. Chem., 43, 1944 (1997).
2) T. Nakanishi, K. Iguchi, and A. Shimizu, Clin. Chem., 49, 829 (2003).
(Measurement Using The Isotope-labeled Compound)3415-v1-Deoxyfructosyl-Val-His-[D7]Leu-Thr-Pro-Glu		New

1-Deoxyfructosyl-Val-His-*Leu-Thr-Pro-Glu*Leu: Leucine-(isopropyl-d7)

-20℃

Vial

50 μg

20,000(Trifluoroacetate Form)(M.W. 863.96)

C37H53D7N8O15

Stable Isotope-Labeled N-Terminal Hexapeptide of HbA1c β -Chain
1) U. Kobold, J.O. Jeppsson, T. Duelffer, A. Finke, W. Hoelzel, and K. Miedema, Clin. Chem., 43, 1944 (1997).
2) T. Nakanishi, K. Iguchi, and A. Shimizu, Clin. Chem., 49, 829 (2003).
(Measurement Using The Isotope-labeled Compound)3417-sNew-20℃

Lys(1-Deoxyfructosyl[13C6])		
Vial
0.1 mg20,00013

C6-DOF-Lys, [13C6]-DFLys
N ε-(1-Deoxy-D-[U-13C]fructos-1-yl)-L-lysine(Trifluoroacetate Form)(M.W. 314.28)

C613C6H24N2O7

Stable Isotope-Labeled Lys(1-Deoxyfructosyl)
1) F. Vinale, V. Fogliano, P. Schieberle, and T. Hofmann, J. Agric. Food Chem., 47, 5084 (1999). (Original)
2) A.D. Troise, Curr. Opin. Food Sci., 19, 15 (2018). (Review)－4－

Peptide Tools (continued)
Code

Compound3420-v

6-[D10]Leu-Glargine		
Vial
20 μg
20,000[[2H10]LeuA13,A16,B6,B11,B15,B17]-Glargine
A-chain: Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-[2H10]Leu-Tyr-Gln[2H10]Leu-Glu-Asn-Tyr-Cys-Gly
B-chain: Phe-Val-Asn-Gln-His-[2H10]Leu-Cys-Gly-Ser-His-[2H10]Leu-Val-Glu-Ala-[2H10]LeuTyr-[2H10]Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-ThrArg-Arg

New
-20℃

Price:Yen(Disulfide bonds between CysA6-CysA11, CysA7-CysB7, CysA20-CysB19)(Trifluoroacetate form)(M.W. 6123.3)

C267H344D60N72O78S6

Stable Isotope-Labeled Insulin Glargine
1) Y. Xu, L. Sun, M. Anderson, P. Belanger, V. Trinh, P. Lavallee, B. Kantesaria, M.J. Marcoux, S. Breidinger,
K.P. Bateman, D. Goykhman, and E.J. Woolf, J. Chromatogr. B, 1063, 50 (2017).

3421-v
New-20℃

4-[D10]Leu-M1		
Vial
20 μg
20,000[[2H10]LeuB6,B11,B15,B17]-M1
A-chain: Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-GlnLeu-Glu-Asn-Tyr-Cys-Gly
B-chain: Phe-Val-Asn-Gln-His-[2H10]Leu-Cys-Gly-Ser-His-[2H10]Leu-Val-Glu-Ala-[2H10]LeuTyr-[2H10]Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr(Disulfide bonds between CysA6-CysA11, CysA7-CysB7, CysA20-CysB19)(Trifluoroacetate form)(M.W. 5790.8)

C255H340D40N64O76S6

Stable Isotope-Labeled Insulin Glargine Metabolite M1
1) Y. Xu, L. Sun, M. Anderson, P. Belanger, V. Trinh, P. Lavallee, B. Kantesaria, M.J. Marcoux, S. Breidinger,
K.P. Bateman, D. Goykhman, and E.J. Woolf, J. Chromatogr. B, 1063, 50 (2017).

3422-v
New-20℃

Lipo-Oxytocin-1		
Vial
LOT-1
Palmitoyl-Cys-Tyr(Palmitoyl)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2

0.5 mg15,000(Disulfide bond between Cys1-Cys6)(M.W. 1484.0)

C75H126N12O14S2

Lipidated Oxytocin Analog with Long-Lasting Activities
1) A. Mizuno, S.M. Cherepanov, Y. Kikuchi, A.A. Fakhrul, S. Akther, K. Deguchi, T. Yoshihara, K. Ishihara, S. Shuto,
and H. Higashida, Brain Sci., 5, 3 (2015). (Original; LOT-1/Novel Oxytocin Analog with Two Palmitoyl Groups)
2) S.M. Cherepanov, S. Yokoyama, A. Mizuno, W. Ichinose, O. Lopatina, A.A. Shabalova, A.B. Salmina,
Y. Yamamoto, H. Okamoto, S. Shuto, and H. Higashida, Pharmacol. Res. Perspect., 5, e00290 (2017).
(Comparative Study with Other LOTs)
3) S.M. Cherepanov, S. Akther, T. Nishimura, A.A. Shabalova, A. Mizuno, W. Ichinose, S. Shuto, Y. Yamamoto,
S. Yokoyama, and H. Higashida, Brain Sci., 7, 132 (2017). (Comparative Study with Other LOTs)

4521-v
New-20℃

FK-565		Heptanoyl-D-Glu(Dpm-D-Ala)
Dpm: meso-diaminopimelyl(M.W. 502.56)

Vial

1 mg

50,000C22H38N4O9

Immunostimulating Peptide

1) Y. Kitaura, H. Takeno, M. Aratani, S. Okada, S. Yonishi, K. Hemmi, O. Nakaguchi, and M. Hashimoto,Experientia, 38, 1101 (1982). (Original)－5－

Carbohydrate and Glycopeptide
Code

Compound22105

Fmoc-Asn[per-O-Boc-(Fucα1-6GlcNAcβ)] 		
Fmoc-Asn[penta-O-Boc-(Fucα1-6GlcNAcβ)]

New
-20℃

Price:Yen
Bulk

10 mg

50,000N α -9-Fluorenylmethoxycarbonyl-N ω-[2,3,4-tri-O-t-butyloxycarbonyl-α-L-fucopyranosyl-(1→6)-3,4-diO-t-butyloxycarbonyl-2-acetamido-2-deoxy-β-D-glucopyranosyl]-L-asparagine(M.W. 1204.3)

C58H81N3O24

Fmoc-Amino Acid for the Synthesis of Fucα (1-6)GlcNAc-β -Asn-Containing Peptide
24016-s
New-20℃[Ara3]CLV3 Peptide		
β-1,2-Linked Triarabinosylated CLAVATA3 Peptide
Arg-Thr-Val-Hyp-Ser-Gly-Hyp(Ara3)-Asp-Pro-Leu-His-His-His

Vial

0.1 mg30,000Hyp(Ara3): 4-O-[β-L-Arabinofuranosyl-(1→2)-β-L-arabinofuranosyl-(1→2)-β-L-arabinofuranosyl]L-hydroxyproline(Trifluoroacetate Form)(M.W. 1877.9)

C78H120N22O32

Tridecapeptide Regulating Stem Cell Fate in the Shoot Apical Meristem of Arabidopsis
1) S.E. Clark, M.P. Running, and E.M. Meyerowitz, Development, 121, 2057 (1995). (Original; cDNA of CLV3)2) K. Ohyama, H. Shinohara, M. Ogawa-Ohnishi, and Y. Matsubayashi,Nat. Chem. Biol., 5, 578 (2009). (Original; [Ara3]CLV3 Peptide)3) H. Shinohara, and Y. Matsubayashi, Plant Cell Physiol., 54, 369 (2013). (Chem. Synthesis)4) S. Betsuyaku, S. Sawa, and M. Yamada, The Arabidopsis Book, 9, e0149 (2011). (Review)

24017-sNew-20℃

Penta-O -glycosylated IgA1 Hinge Region Peptide		Vial[Thr(GalNAc)4,7,15, Ser(GalNAc)9,11]-IgA1 Hinge Region Peptide
Val-Pro-Ser-Thr(GalNAc)-Pro-Pro-Thr(GalNAc)-Pro-Ser(GalNAc)Pro-Ser(GalNAc)-Thr-Pro-Pro-Thr(GalNAc)-Pro-Ser-Pro-Ser-NH2

0.1 mg20,000(Trifluoroacetate Form)(M.W. 2846.0)

C121H193N25O53

IgA1 Hinge Portion Related to IgA Nephropathy
1) T.S. Mattu, R.J. Pleass, A.C. Willis, M. Kilian, M.R. Wormald, A.C. Lellouch, P.M. Rudd, J.M. Woof, and
R.A. Dwek, J. Biol. Chem., 273, 2260 (1998). (Assignment of Glycosylation Site of IgA1 Hinge Region)2) I. Nakamura, H. Iwase, K. Arai, Y. Nagai, K. Toma, T. Katsumata, Y. Hiki, T. Kokubo, T. Sano, and Y. Kobayashi,
Nephrology (Carlton), 9, 26 (2004).

4522-v
New-20℃

IgA1 Hinge Region Peptide		
Nonglycosylated IgA1 Hinge Region Peptide
Val-Pro-Ser-Thr-Pro-Pro-Thr-Pro-Ser-Pro-Ser-Thr-Pro-ProThr-Pro-Ser-Pro-Ser-NH2

Vial

0.5 mg10,000(Trifluoroacetate Form)(M.W. 1830.0)

C81H128N20O28

IgA1 Hinge Portion Related to IgA Nephropathy
1) T.S. Mattu, R.J. Pleass, A.C. Willis, M. Kilian, M.R. Wormald, A.C. Lellouch, P.M. Rudd, J.M. Woof,
and R.A. Dwek, J. Biol. Chem., 273, 2260 (1998). (Assignment of Glycosylation Site of IgA1 Hinge Region)2) I. Nakamura, H. Iwase, K. Arai, Y. Nagai, K. Toma, T. Katsumata, Y. Hiki, T. Kokubo, T. Sano, and Y. Kobayashi,
Nephrology (Carlton), 9, 26 (2004).

－6－

Enzyme Inhibitors and Miscellaneous Products
CodeCompound

4519
New

Ile-Pro-Pro		
Bulk 25 mg
18,000IPP		
100 mg50,000-20℃

L-Isoleucyl-L-Prolyl-L-Proline(M.W. 325.40)

Price:Yen

C16H27N3O4

ACE1 Inhibitor / Antihypertensive Tripeptide
1) M. Kohmura, N. Nio, and Y. Ariyoshi, Agric. Biol. Chem., 54, 835 (1990).
2) Y. Nakamura, N. Yamamoto, K. Sakai, and T. Takano, J. Dairy Sci., 78, 1253 (1995).
3) S. Li, T. Bu, J. Zheng, L. Liu, G. He, and J. Wu, Compr. Rev. Food Sci. Food Saf., 18, 1097 (2019). (Review)

New

Val-Pro-Pro		
Bulk 25 mg
18,000VPP		
100 mg50,000-20℃

L-Valyl-L-Prolyl-L-Proline

4520(M.W. 311.38)

C15H25N3O4

ACE1 Inhibitor / Antihypertensive Tripeptide
1) Y. Nakamura, N. Yamamoto, K. Sakai, and T. Takano, J. Dairy Sci., 78, 1253 (1995). (Original)
2) S. Li, T. Bu, J. Zheng, L. Liu, G. He, and J. Wu, Compr. Rev. Food Sci. Food Saf., 18, 1097 (2019). (Review)3244

Cyclo(Ala-Pro)		

New

Cyclo(Pro-Ala), Cyclo(-Ala-Pro-)-20℃(M.W. 168.19)

Bulk

25 mg

12,000

Bulk

25 mg

12,000

Bulk

25 mg

12,000

Bulk

25 mg

12,000C8H12N2O2

Cyclic Dipeptides (Diketopiperazines)
3245

Cyclo(Lys-Pro)		

New

Cyclo(Pro-Lys), Cyclo(-Lys-Pro-)-20℃(M.W. 225.29)

C11H19N3O2

Cyclic Dipeptides (Diketopiperazines)
3246

Cyclo(Pro-Pro)		

New

Cyclo(-Pro-Pro-)-20℃(M.W. 194.23)

C10H14N2O2

Cyclic Dipeptides (Diketopiperazines)
3247

Cyclo(Pro-Thr)		

New

Cyclo(Thr-Pro), Cyclo(-Pro-Thr-), Cyclo(-Pro-Thr)-20℃(M.W. 198.22)

C9H14N2O3

Cyclic Dipeptides (Diketopiperazines)－7－

Enzyme Substrates and Miscellaneous Products
CodeCompound3243-vPhe-Met-MCA		

New

L-Phenylalanyl-L-methionine 4-methylcoumaryl-7-amide-20℃

Price:Yen
Vial

5 mg

5,000

(Tosylate Form)(M.W. 453.55)

C24H27N3O4S

Substrate for Bacterial Dipeptidyl Peptidase-7
1) T.K. Nemoto, T. Ono, and Y. Ohara-Nemoto, Anal. Biochem., 548, 78 (2018). (Original)

3248-v

Z-Gly-Gly-Arg-MCA		New

Benzyloxycarbonyl-glycylglycyl-L-arginine 4-methylcoumaryl-7-amide-20℃(HCl Form)(M.W. 579.60)

Vial

5 mg

5,000

C28H33N7O7

Substrate for Thrombin
1) M. Zimmermzn, J.P. Quigley, B. Ashe, C. Dorn, R. Goldfarb, and W. Troll,Proc. Natl. Acad. Sci. U. S. A., 75, 750 (1978). (Original)
2) J. Kintigh, P. Monagle, and V. Ignjatovic, Res. Pract. Thromb. Haemost., 2, 42 (2018).
(Review; Substrate for Thrombin)

3412-vVial
5 mg
20,000β-Ala-Lys(AMCA)		

New

β-Alanyl-N ε-(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-acetyl)-L-lysine-20℃(Trifluoroacetate Form)(M.W. 432.47)

C21H28N4O6

Fluorescent Tracer for Oligopeptide Transporters
1) C. Otto and K. Bauer, Anat. Rec., 245, 662 (1996). (Original)
2) S.T. Dieck, H. Heuer, J. Ehrchen, C. Otto, and K. Bauer, Glia, 25, 10 (1999).
(Biochem.; Fluorescent Reporter Peptide)3) K. Ito, A. Hikida, S. Kawai, V.T.T. Lan, T. Motoyama, S. Kitagawa, Y. Yoshikawa, R. Kato, and Y. Kawarasaki,Nat. Commun., 4, 2502 (2013). (Biochem.; Substrate for Peptide Transporter)

3416
New
-20℃

Azido-PEG3-DYKDDDDK		
Bulk 2 mg
15,000N3PEG3-DYKDDDDKN3PEG3-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys(Trifluoroacetate Form)(M.W. 1228.2)

C49H73N13O24

For the Attachment of the Flag Tag by Click Chemistry1) H.C. Kolb, M.G. Finn, and K.B. Sharpless, Angew. Chem. Int. Ed., 40, 2004 (2001). (Review; Click Chemistry)2) P. Thirumurugan, D. Matosiuk, and K. Jozwiak, Chem. Rev., 113, 4905 (2013). (Review; Click Chemistry)－8－カタログ製品に関して
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