October 9, 2018

The Japan Society of Mechanical Engineers
Hokkaido Branch“Biomechanics Research Meeting”
34th Seminar
Chairman: Toshiro Ohashi
The Biomechanics Research Meeting will sponsor presentations by Prof. M. Ricardo Ibarra from
University of Zaragoza, Spain. Faculty members, graduate students, and undergraduates areencouraged to participate in the seminar.
Date&Time: October 29, 2018, 11:00 - 12:00
Place: Room#A1-17, Faculty of Engineering, Hokkaido University
Speaker: Prof. M. Ricardo Ibarra
Institute of Nanoscience of Aragon, University of Zaragoza, Spain
Laboraotry of Advanced Microscopies, University of Zaragoza, Spain
Department of Condensed Physics, University of Zaragoza, Spain
Title: Optimization of the magnetic nanovector for focused hyperthermia
Magnetic nanoparticles are considered as promising nanovectors in tumor treatment at the clinic. It
is relevant the knowledge of the mechanism triggering the cell dead using magnetic nanoparticles astargeting vectors. In particular, the design of this nanovector is fundamental, in order to induce cell
death in “in vitro” experiment. Their design will be relevant for the influence of the physicalproperties the applied electromagnetic field [1], magnetic nanoparticles properties [2], cell lines [3]and internal biodistribution in cells [4]. I report that the tune of different parameters could makesuitable procedures in order to trigger the cell death following the apoptosis or necrosis mechanisms.
The drastic effect of the intracellular damage induced by magnetic hyperthermia is a key issue for theuse of magnetic functional nanoparticles in focused therapies in comparison with exogenous heating[5]. Our results demonstrate that a complex interplay of physical effect in “in vitro” models make thistechnique a very promising alternative or adjuvant therapy for tumor treatment and that theoptimization of the functional nanomaterials is relevant for their application.
[1] “Controlled cell death by magnetic hyperthermia: effects of time, field amplitude and nanoparticle
concentration” , L. Asín, M. R. Ibarra, A. Tres and G. F. Goya. Pharmaceutical Research, 29(5), 2012,1319-1327. DOI: 10.1007/s11095-012-0710-z[2] "Cell Bystander Effect Induced by Radiofrequency Electromagnetic Fields and Magnetic Nanoparticles", byM. P. Calatayud, L. Asin, A. Tres, G.F. Goya and M.R. Ibarra. Current Nanoscience, 2016, 12(3) pp372-37[3] “Cell damage produced by magnetic fluid hyperthermia on microglial BV2 cells” M.P. Calatayud, E. Soler,
T.E. Torres, E. Campos-Gonzalez, C. Junquera, M.R. Ibarra, G.F. Goya. Scientific Reports, 7 (1) 8627(2017). DOI: 10.1038/s41598-017-09059-7[4] “In silico before in vivo: recognizing the key elements to predict the heating efficiency of magnetic
nanoparticles within the intracellular space.” B. Sanz, M.P. Calatayud, E. De Biasi, E. Lima Jr., M. Vasquez

Mansilla, R.D. Zysler, M.R. Ibarra, and G.F. Goya. Scientific Reports. 6:38733 Dec 7 (2016) DOI:
10.1038/srep38733[5] “Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating” B. Sanz, M.P. Calatayud,
T.E. Torres, M.L. Fanarraga, M.R. Ibarra and G.F. Goya. Biomaterials 114 (Jan 2017) 62–70.
DOI:10.1016/j.biomaterials.2016.11.

Contact:
Toshiro Ohashi, Faculty of Engineering, Hokkaido University
Tel&Fax: 011-706-6424, Email: ohashi@eng.hokudai.ac.jp