2019 年 6 月 23 日	 
日本機械学会北海道支部	  バイオメカニクス懇話会	 
第 36 回講演会	 	 （共催：日本機械学会北海道支部，日本機械学会バイオエンジニアリング部門「計測と力学̶生体への応用̶」研究会）	 
主査	  大橋	  俊朗	  下記の要領にて第 36 回講演会を開催いたします．本講演会は日本機械学会北海道支部特別講演会，日本機械学会バイオエンジニアリング部門第 62 回「計測と力学-生体への応用-」研究会と共催いたします．皆様のご参加をお待ちしております．
記日	  時：2019 年 7 月 4 日（木），16:00~17:30
場	  所：北海道大学大学院工学研究院・工学部	  大会議室 A1-17 室
http://www.eng.hokudai.ac.jp/building/?place=outer
講	  演：
16:00~16:45「Complex Adaptive Cancer Immunotherapy」
Prof. In-San Kim
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science andTechnology (KIST), Korea/KU-KIST Graduate School of Converging Science andTechnology, Korea University, Korea
Immunotherapy is revolutionizing the treatment of cancer. The current immunotherapeutics
that work by taking the brakes off T cells have been particularly transformational, dramatically
improving outcomes for some cancer patients. But we still need to answer to those patients
whose cancers do not respond to these immunotherapeutics, and those whose cancers respondinitially but then become resistant to the treatments. The more we study the major issues oftumors, the more we come to realize that they cannot be understood in isolation. Tumors aresystemic problems, which mean that they are interconnected and interdependent. Cancer cells
are present within a complex adaptive ecosystem consisted of associated cells including
immune cells, connective tissue cells, endothelial cells within a scaffold of matrix altogether
forming tumor microenvironment. Cancer, perhaps uniquely among human illnesses, is adisease that arises through Darwinian interactions of microenvironmental selection andphenotypic adaptation, which are both causes and consequences of its complexity andheterogeneity. Since a life has begun 3.5 billion years ago, they ensured continuous interaction
between the diverse species, both cooperative and fiercely competitive in nature. So they havedeveloped complex and sophisticated immune system to survive. Can we develop bettersystems to fight against cancer than our own immune system? Even though we do notunderstand completely our own immune systems, we could try at least to awaken our own

immune system to fight against cancer. In an attempt to trigger our own immunity against
cancers, we utilized the characteristic of genetic instability to our advantage, as the expressionof cancer cell neoantigens triggers immunity against cancer cells, which can be called“intrinsic cancer vaccination”. For this purpose, we designed protein nanocages orextracellular vesicles (exosomes), which hold not only ligands for enhancing cancer cell
phagocytosis but also drugs for inducing immunogenic cancer cell death. This strategy willallow us to avoid using known tumor specific antigens, ex vivo manipulation and adoptive celltherapy, instead, efficiently present neoantigens of cancer cells to our immune system. This
strategy could be combined with other treatment modalities to potentiate the therapeuticefficacy.
16:45~17:30「H-TRAIN : Hongreung Biomedical Cluster」
Prof. Kuiwon Choi
Principal Investigator, H-TRAIN Program, Korean Institute of Science and Technology(KIST), Korea
H-TRAIN Program is a translational research program developed in 2018. The purpose ofthe program is to facilitate commercialization of the biomedical technologies developed inKIST. This program is originated from Translational Research Center (TRC) Program in KIST
since 2012, then updated and renamed as H-TRAIN. Hongreung is the area where the origin ofKorean R&D since 1966 when KIST was developed. KAIST has once also been located in thisarea, although KASIT moved to other city in late 1980’s. Around this area there exist morethan 10 universities, 2 major university hospitals, 2 specialized government hospitals and 3
government-sponsored research institutes including KIST. Approximately 5,000 ph.D.s areworking in this area. Recently, Seoul city developed the Seoul Bio-hub in this area to promoteindustrialization of biomedical technologies as an accelerating organization. For now, there
are more than 30 start-ups are under incubation and more start-ups will be accommodated
soon. In Korea, the biomedical area is now considered as one of main future growth engine ofKorean economy. Thus a lot of efforts both from the Government and local governments has
been put into this area. The role of GRIs becomes more emphasized and the industrializationof the biomedical technologies is essential to the future of Korea. This is why H-TRAIN wasborn in KIST. In this presentation, I will introduce the H-TRAIN program along with thefuture of Hongreung Biomedcal Cluster.

問い合わせ先：大橋	  俊朗	  	  北海道大学大学院工学研究院人間機械システムデザイン部門
Tel&Fax: 011-706-6424, Email: ohashi@eng.hokudai.ac.jp