Reagentsfor Peptide
Synthesis

Reagents for Peptide Synthesis ……………………… 304
Reagents– 303 –Reagents for Peptide Synthesis
CodeCompoundPrice:Yen1037(Boc)2O*

2～10

Di-t-butyl dicarbonate(M.W.218.25) C10H18O5
Purity: higher than 99%

25 g
100 g
500 g

[24424-99-5]

3,200
9,700
37,6001) L. Moroder, A. Hallet, E. Wu
nsch, O. Keller, and G. Wersin, Hoppe Seyler's Z. Physiol. Chem., 357,1651 (1976).

1033

N-Carboethoxy Phthalimide

2～10

N-(Ethoxycarbonyl)phthalimide
Nefkens' Reagent(M.W.219.19)

C11H9NO425 g
100 g
500 g

2,700
6,600
23,8005g
25 g
100 g

2,500
6,000
20,000[22509-74-6]

1) G.H.L. Nefkens, Nature, 185, 309 (1960).

1048

6-Cl-HOBt

2～10

6-Chloro-1-hydroxybenzotriazole(M.W. 169.57 )C6H4N3OCl[26198-19-6]

1) G. Sabatino, B. Mulinacci, M.C. Alcaro, M. Chelli, P. Rovero, and A.M. Papini, Lett. Pept. Sci., 9, 119 (2002).

1001

DCCD

2～10

Dicyclohexylcarbodiimide(M.W.206.33)

C13H22N2500 g

16,000

25 g
100 g

2,000
6,5005g
25 g
100 g

5,000
15,00045,0001g
5g
25 g

4,000
16,00063,000[538-75-0]

Crystalline Mass
1) J.C. Sheehan and G.P. Hess, J. Am. Chem. Soc., 77, 1067 (1955).

1024

EEDQ

2～10

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline(M.W. 247.29)

C14H17NO3[16357-59-8]

1) B. Belleau and G. Malek, J. Am. Chem. Soc., 90, 1651 (1968).
2) H. Yajima and H. Kawatani, Chem. Pharm. Bull., 19, 1905 (1971).

1042

Fmoc-OSu-20

N-(9-Fluorenylmethoxycarbonyloxy)succinimide[9-Fluorenylmethyl N-succinimidyl carbonate](M.W. 337.33)

C19H15NO5[82911-69-1]

1) A. Paquet, Can. J. Chem., 60, 976 (1982).

1043

HATU*-20

1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo(4,5-b) pyridinium
3-oxide hexafluorophosphate(M.W. 235.27 • 144.96)

C10H15N6O • PF6[148893-10-1]

Coupling Reagent for Peptide Synthesis
1) L. A. Carpino, J. Am. Chem. Soc., 115, 4397 (1993).
2) I. Abdelmoty, F. Albericio, L.A. Carpio, B.M. Foxman, and S.A. Kates, Lett. Pept. Sci., 1, 57 (1994).
• Domestic service only; This product is sold under the agreement with Applied Biosystems.
● この頁の商品は輸送の都合上、その販売業務をナカライテスク(株)など当社指定の試薬業者に委託することがございますのでご了承下さい。

*Cannot be mailed outside of Japan– 304 –Reagents for Peptide Synthesis (continued)
Code

CompoundPrice:Yen

1046

HBTU

2～10

1-[Bis(dimethylamino)methylene]-1H-benzotriazolium
3-oxide hexafluorophosphate(M.W. 234.28 · 144.96)

C11H16N5O · PF62,500
6,000
20,000

5g
25 g
100 g

2,500
6,000
20,000[94790-37-1]

1047

HCTU

2～10

1-[Bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium
3-oxide hexafluorophosphate(M.W. 268.72 · 144.96)

5g
25 g
100 g

C11H15N5OCl · PF6[330645-87-9]1) G. Sabatino, B. Mulinacci, M.C. Alcaro, M. Chelli, P. Rovero, and A.M. Papini, Lett. Pept. Sci., 9, 119 (2002).

1022

HOBt

RT

1-Hydroxybenzotriazole(M.W. 135.12)

C6H5N3O

25 g
100 g

3,200
8,400

25 g
100 g

3,400
9,200

[2592-95-2]

1) W. Konig and R. Geiger, Chem. Ber., 103, 788 (1970).

1011

HOSuRTN-Hydroxysuccinimide(M.W. 115.09)

C4H5NO3[6066-82-6]

1) G.W. Anderson, J.E. Zimmerman, and F.M. Callahan, J. Am. Chem. Soc., 86, 1839 (1964).

1020

WSCD*-20

(Water-soluble carbodiimide)

[EDC]

5g
25 g
100 g

4,500
15,00055,000

5g
25 g
100g

4,000
12,00040,000

25 g
100 g

3,000
9,000

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide(M.W. 155.24)

C8H17N3[1892-57-5]

1) J.C. Sheehan, P.A. Cruickshank, and G.L. Boshrt, J. Org. Chem., 26, 2525 (1961).

WSCD • HCl

2～10(Water-soluble carbodiimide hydrochloride)[EDC • HCl]
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride(M.W. 155.24 • 36.46)

C8H17N3 • HCl[25952-53-8]

1) J.C. Sheehan, P.A. Cruickshank, and G.L. Boshrt, J. Org. Chem., 26, 2525 (1961).

1045

Z-OSu

2～10

N-(Benzyloxycarbonyloxy)succinimide(M.W. 249.22)

C12H11NO5[13139-17-8]1) M. Frankel, D. Ladkany, C. Gilon, and Y. Wolman, Tetrahedron Lett., 39, 4765 (1966).
● この頁の商品は輸送の都合上、その販売業務をナカライテスク(株)など当社指定の試薬業者に委託することがございますのでご了承下さい。

*Cannot be mailed outside of Japan– 305 –Reagents1030

– 306 –