2018 年 10 月 9 日	 
日本機械学会北海道支部	  バイオメカニクス懇話会	 
第 34 回講演会	 	 （共催：日本機械学会北海道支部，日本機械学会バイオエンジニアリング部門「計測と力学̶生体への応用̶」研究会，日本生体医工学会専門別研究会「バイオメカニクス研究会」）	 
主査	  大橋	  俊朗	  下記の要領にて第 34 回講演会を開催いたします．本講演会は日本機械学会北海道支部特別講演会，日本機械学会バイオエンジニアリング部門第 60 回「計測と力学-生体への応用-」研究会，日本生体医工学会専門別研究会「バイオメカニクス研究会」第170 回研究会と共催いたします．皆様のご参加をお待ちしております．
記日	  時：2018 年 10 月 29 日（月），11:00~12:00
場	  所：北海道大学大学院工学研究院・工学部	  大会議室 A1-17 室
http://www.eng.hokudai.ac.jp/building/?place=outer
講	  演：「Optimization of the magnetic nanovector for focused hyperthermia」
Prof. M. Ricardo Ibarra
Institute of Nanoscience of Aragon, University of Zaragoza, Zaragoza 50420 Spain
Laboraotry of Advanced Microscopies, University of Zaragoza, Zaragoza 50420, Spain
Department of Condensed Physics, University of Zaragoza, Zaragoza 50420, Spain
Magnetic nanoparticles are considered as promising nanovectors in tumor treatment at theclinic. It is relevant the knowledge of the mechanism triggering the cell dead using magnetic
nanoparticles as targeting vectors. In particular, the design of this nanovector is fundamental,
in order to induce cell death in “in vitro” experiment. Their design will be relevant for theinfluence of the physical properties the applied electromagnetic field [1], magnetic
nanoparticles properties [2], cell lines [3] and internal biodistribution in cells [4]. I report thatthe tune of different parameters could make suitable procedures in order to trigger the cell
death following the apoptosis or necrosis mechanisms. The drastic effect of the intracellular
damage induced by magnetic hyperthermia is a key issue for the use of magnetic functional
nanoparticles in focused therapies in comparison with exogenous heating [5]. Our resultsdemonstrate that a complex interplay of physical effect in “in vitro” models make thistechnique a very promising alternative or adjuvant therapy for tumor treatment and that theoptimization of the functional nanomaterials is relevant for their application.
[1] “Controlled cell death by magnetic hyperthermia: effects of time, field amplitude and nanoparticle
concentration” , L. Asín, M. R. Ibarra, A. Tres and G. F. Goya. Pharmaceutical Research, 29(5), 2012,

1319-1327. DOI: 10.1007/s11095-012-0710-z[2] "Cell Bystander Effect Induced by Radiofrequency Electromagnetic Fields and Magnetic Nanoparticles", by
M. P. Calatayud, L. Asin, A. Tres, G.F. Goya and M.R. Ibarra. Current Nanoscience, 2016, 12(3) pp372-37[3] “Cell damage produced by magnetic fluid hyperthermia on microglial BV2 cells” M.P. Calatayud, E. Soler,
T.E. Torres, E. Campos-Gonzalez, C. Junquera, M.R. Ibarra, G.F. Goya. Scientific Reports, 7 (1) 8627 (2017).
DOI: 10.1038/s41598-017-09059-7[4] “In silico before in vivo: recognizing the key elements to predict the heating efficiency of magnetic
nanoparticles within the intracellular space.” B. Sanz, M.P. Calatayud, E. De Biasi, E. Lima Jr., M. Vasquez
Mansilla, R.D. Zysler, M.R. Ibarra, and G.F. Goya. Scientific Reports. 6:38733 Dec 7 (2016) DOI:
10.1038/srep38733[5] “Magnetic hyperthermia enhances cell toxicity with respect to exogenous heating” B. Sanz, M.P. Calatayud,T.E. Torres, M.L. Fanarraga, M.R. Ibarra and G.F. Goya. Biomaterials 114 (Jan 2017) 62–70.
DOI:10.1016/j.biomaterials.2016.11.

問い合わせ先：大橋	  俊朗	  	  北海道大学大学院工学研究院人間機械システムデザイン部門
Tel&Fax: 011-706-6424, Email: ohashi@eng.hokudai.ac.jp