2023 年 6 月 24 日
日本機械学会北海道支部 バイオメカニクス懇話会
第 41 回講演会（共催：日本機械学会北海道支部、日本生体医工学会専門別研究会「バイオメカニクス研究会」
）
主査

大橋俊朗

下記の要領にて第 41 回講演会を日本機械学会北海道支部特別講演会、日本生体医工学会専門別研究会「バイオメカニクス研究会」第 176 回研究会との共催として開催いたします。皆様のご参加をお待ちしております。
記
日 時：2023 年 7 月 6 日（木），10:30〜12:00
場 所：北海道大学工学部工学部 L 棟 L252
講 演：
10:30 - 11:15「Mechanical Factors for Pre-Osteoarthritis」
Prof. Ashvin Thambyah, Department of Chemical and Materials Engineering,
University of Auckland, New Zealand
Abstract:
The aim of our research has been to understand, from mechanical and structural viewpoints,
the initial degenerative processes in the joint tissues, related to the initiation and progressionof osteoarthritis (OA). To this end we have established an animal model to study early or
pre-OA joint tissue degeneration. Our work is framed around addressing three researchquestions. Does the initiation of OA begin with changes in (1) cartilage or bone, (2)proteoglycans or collagen, (3) cells or tissue? Our studies have shown that in the early
degenerative state of the joint tissues, where macro-scale mechanical properties are yet to beaffected, micro-to-nano scale destructuring of the collagen network had already taken place.
These collagen network changes were found to be strongly associated with bone cement-line
microstructural changes. The changes in the bone-cement line were indicated by the presenceof ‘bone spicules’, which were remarkably similar to ‘cutting cones’ seen in primary boneformation during fracture healing. This similarity provided a mechanical rationale for the bonechanges in the joint system in early tissue degeneration. The collagen network and bone
structural changes were also associated with significant changes in an ensemble of proteins.
These included certain SLRPs, angiogenic proteins and TGF-β. High resolution imaging of thechondrons, in tissues exhibiting early cartilage degeneration, further revealed fibrillar-structurechanges in the territorial matrix and pericellular capsule, showing a morphology likened tothickened baskets of fibrillar encapsulation of the chondrocytes. The significance of the above
descriptions, of the multi-length scale tissue and cell mechanics in the joint, are discussed witha view on how OA is initiated by mechanical factors.

11:15 - 12:00「Safer Personalised Medical Implants」
Prof. Peter Vee Sin Lee, Department of Biomedical Engineering, University ofMelbourne, Australia
Abstract:
Advances in computer-aided engineering, patient-specific computer models, and additive
manufacturing transform patients' treatment through personalised solutions. Manufacturers
and hospitals are now trialling 'bespoking' as the new standard of care in orthopaedics andmaxillofacial surgery. However, there are significant challenges to facilitating personalised
medical implant commercialisation and widespread use. Regulatory frameworks for
personalised implants are in their early stages. Current standards for testing off-the-shelfdevices are not directly transferrable to devices designed for individual patients. Instead,future test standards could be based on information from the patient's anatomy and evenlifestyle. There is no well-defined framework or methodology to support the use and increase
personalised implants' success rate. The fabrication of the implant is only the first step.
Successful treatment requires a comprehensive approach to optimise the use of thepersonalised medical device. This presentation will focus on the development of a seamless
framework based on the Measure-Model-Manufacture-Manage (4M) for point-of-caremanufacturing. Comprehensive biomechanical measurements will be used to build
patient-specific biomechanical models to represent the underlying physiology of the humanbody. The models will be used to analyse scenarios that are too expensive or infeasible toperform on patients directly (e.g. loading an implant to failure in the human body). The aim in
the measure-model stage is to optimise implant/device design that considers all
the biomechanical information before manufacturing using 3D printing. Finally, themeasure-model-manufacture becomes a reinforcing loop that improves patient management
and outcome. The presentation will also discuss our experience and benefits, from a
researcher's perspective, working closely with physicians, industry, and government leaders inpushing the frontiers of personalised medical implants.

世話人・問い合わせ先：
大橋 俊朗

北海道大学大学院工学研究院人機械・宇宙航空工学部門

Tel&Fax: 011-706-6424, Email: ohashi@eng.hokudai.ac.jp