50 years of JSNP Messages fromWorldwide experts

目次

【巻頭言】
⼤隅典⼦（第 50 回⽇本神経精神薬理学会会⻑）…

5

⽇本神経精神薬理学会（JSNP）の誕⽣から国際化まで 50 年 …

9

新⽥淳美

夢の国になれるか？

13橋本亮太統合失調症薬物治療ガイドラインの作成・普及・教育・検証活動【50 周年記念シンポジウム記録】
NPBPPP2020 で⾏われたシンポジウムの抄録（登壇順，敬称略）

鍋島俊隆・⼭脇成⼈…

⽇本神経精神薬理学会から世界を変える ！

…

15

吾郷由希夫

未来への想い / We make the Future

…

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内⽥裕之

エニグマ

…

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座⻑：池⽥和隆・中込和幸【50 years of JSNP ~ Messages from Worldwide Experts】
海外から寄せられた祝詞（Last name ABC 順, 敬称略）

Siegfried Kasper

50th Anniversary JSNP, letter of Appreciation…

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Jun Soo Kwon

Letter for 50th anniversary of JSNP…

25

Herbert Meltzer

Letter for 50th anniversary of JSNP…

27

Anthony Phillips

Letter for 50th anniversary of JSNP…

29

Tian-Mei Si

海納百川、有容乃⼤…

31

Tun-Ping Su

Letter for 50th anniversary of JSNP…

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Chay Hoon Tan

Letter for 50th anniversary of JSNP…

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Andi Tanra

Letter for 50th anniversary of JSNP…

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Joseph Zohar

Letter for 50th anniversary of JSNP…

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50th Anniversary JSNP, letter of Appreciation

Kasper Siegfried
Professor Emeritus and Former Chair, Department of Psychiatry andPsychotherapy,Medical University of Vienna, Waehringer Guertel 18-20, 1090
VIENNA, Austria
President of International College of Neuropsychopharmacology(CINP), https://cinp.org
E-Mail: siegfried.kasper@meduniwien.ac.at, Publications of KASPER
Siegfried in Google Scholar

Since the year 1990 I am frequently travelling to Japan to give lectures indifferent university departments and research institutions, as well asparticipating in national as well as international scientific meetings. I wasalways impressed by the high level of scientific knowledge and soundness ofthe preparation of meetings and individual lectures of the established as wellas the young researchers. The Japanese colleagues excellently managed tocombine clinical knowledge and scientific progress for the benefit of theunderstanding and treatment of psychiatric patients. With pleasure I did noticethat in some Japanese hospitals charts of patients still contain German
wordings of disease states, like “Sensitiver Beziehungswahn” or “Vorbeireden”
which indicates that former colleagues came from Japan to Germany andAustria to learn our psychopathological system as well as disease
understandings. However, nowadays the US System, exemplified by DSM has
taken over the daily routine, but could benefit from a more sound knowledgeof European Disease understandings.

21In international meetings the Japanese nights were always one of the highlightsof the meeting like the one, organized by Prof. Yamawaki, which we had with
our past CINP president and Nobel laureate Arvid Carlsson in Stockholm in2012.

Our colleagues of Japan are very instrumental in organizing also joint meetings
inviting Asian colleagues as well as international renown researchers likerecently the joint AsCNP/JSNP/JSCNP congress which was held with muchsuccess in Fukuoka in 2019 organized so excellently by Prof. Ikeda.

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Not only the science of Japan captured my interest and emotional feelings, butalso the Japanese culture, with all the dedication into details which evolved outof thepreservation of customs overcenturies and its knowledge.

In 2012 I had the pleasure being dressed like a samurai since I informed mycolleagues that I am collecting Tsubas among other cultural items of Japan.

My true highlight however was in 2013 when I did have the privilege topersonally great and shake hands with The Japanese Emperor and The
Japanese Empress before the opening ceremony of the WFSBP congress inKyoto, which was organized by Prof Takeda.
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I sincerely hope that the Japanese-Austrian friendship and collaboration will
last beyond my active life.

24Letter for 50th anniversary of JSNP
I am hugely pleased to congratulate 50th anniversary of JSNP. It ought to beapplauded that researchers and clinicians have developed neuropharmacologicalknowledge and contemplate psychiatric issues via this society for a half of century. I
would like to highly admire the efforts of current and previous presidents, vicepresidents, trustees, and all members from JSNP.
I appreciate JSNP’s active collaboration with industry and government todevelop new, effective drugs, the establishment of the system to stratify mental
disorders, and substantial, high-quality database construction. Further, JSNP is
maintaining an inseparable relationship with South Korean researchers and clinicians.
Thanks to the activities in international societies, such as the International
College of Neuropsychopharmacology (CINP), researchers from all around the world,
including South Korea, have been motivated by JSNP’s integrative approaches indeveloping drugs and their related mental illness. In particular, I appreciate thecontribution of JSNP to the Asian College of Neuropsychopharmacology (AsCNP)
which is growing fast, and the association has been a great opportunity to share anddevelop research for many Asian researchers and clinicians.

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I sincerely hope that JSNP keeps playing an important role in basic and clinicalpsychiatric research all around the world as well as in Asian society. Again,
congratulations for 50th anniversary of JSNP.
All the best,

Jun Soo Kwon, MD, PhD
Past President of Korean Neuropsychiatric Association
Department of Psychiatry, Seoul National University College of Medicine
Department of Brain and Cognitive Sciences, College of Natural Sciences
Director, Institute of Human Behavioral Medicine
Seoul National University, Seoul, Republic of Korea

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Letter for 50th anniversary of JSNP
Herbert Meltzer, MD
Professor of Psychiatry, Pharmacology and Physiology
Northwestern University Feinberg School of Medicine

Neuropsychopharmacology in Japan has a special place in my heart. For
over forty years, I have had the great privilege of knowing leaders inpsychopharmacology and psychiatry during that period, until the present day.
I have mentored many young Japanese psychopharmacologists who joined
my laboratory for several years at a time. Many have gone on to become
leaders of Japanese academic programs and program leaders inpharmaceutical companies in Japan.
I have been a consultant and grantee
from many Japanese pharmaceutical companies. I have been invited overa dozen time to speak in Japan at national and international meetings and am
planning to return later this year. I treasure my trips to Kyoto, Osaka andTokyo. I have collected many beautiful works of art from Japanese artists.
I continue to do so.

AsCNP/JSNP/JSCNP2019 Fukuoka Congress27Beautiful works of art from Japanese artists in my house

My participation in the 2020 50Th Anniversary of the JSNP is particularly
meaningful to me. It is an honor to be a plenary speaker and to have theoccasion to meet with many colleagues. I look forward to continuing
opportunities to visit Japan and to work with Japanese scientists engaged in
the field I continue to find fascinating. I hope there will be more visits.
Ifeel a great kinship to Japan and extend my congratulations to all who madeit such a memorable meeting.
I wish the Society a great future and hope
to continue my association with it.

With warmest regards,
Herbert Meltzer, MD

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UNIVERSITY OF BRITISH COLUMBIA

June 18th, 2020
Dear Colleagues:
It is with great pleasure and personal honour that I offer my congratulations to the JapaneseSociety of Neuropsychopharmacology, on achieving its ‘Golden’ 50th Anniversary.
The many accomplishments of this senior Society within the world neuropsychopharmacology
community, are legendary including its role as an ‘early adopter’ of the concept thatneuropsychiatric ill health reflects underlying disturbances of brain function, especially thoserelated to chemical neurotransmission.
I first encountered the depth of knowledge and the breadth of talent within the Japaneseneuroscience community in general and neuropsychopharmacology in particular, as a member ofa delegation from the Medical Research Council of Canada to the Japan Science Council in 1996.
Professor Masao Ito was President of the JSC at that time and was playing leading role in shaping
new programs in response to the declaration of The Decade of the Brain by the Nakasone
government of Japan. Thus began a long and fruitful adventure that has included annual visits toJapan, continuing to the present day.
A particularly enjoyable period of collaboration with JSNP colleagues began when I joined theExecutive Council of CINP in 2008. This relationship grew even closer when I was elected
President of CINP (2012-2014) and enjoyed a warm friendship with many Japanese colleagues,
especially Shigeto Yamawaki, who was my successor as President of CINP, along with Toshikazu
Saito, and Kazutaka Ikeda. From this perspective, I had a front row seat to witness the growing
strength and generosity of the JSNP as it played a leading role in expanding
neuropsychopharmacology research throughout Asia.
Given the prevalence of mental ill-health throughout the world, it is now clearer than ever that thedevelopment of new and effective diagnostic and therapeutic options will require international
collaboration and a broad and compassionate world vision that recognizes good mental health asa human right. In this context it is comforting to know that JSNP will continue to play a leading roleas it enter its second 50 year cycle.
Thanks again for including me on this voyage!
Warm regards,

Anthony G. Phillips, C.M., PhD, FRSC, FCAHS.
Professor, Department of Psychiatry.
Senior Scientist, Djavad Mowafaghian Centre for Brain Health.
Faculty of Medicine,University of British Columbia.
3402-2215 West Mall
Vancouver, BC, Canada29

Japan Night at 2nd AsCNP Congress in 2011 (Seoul)

Visit to Otsuka Pharmaceutical Co., Ltd. in 2012

Visit to a Ryotei in Tokyo in 2012（田町，牡丹）

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海纳百川,有容乃大---Congratulations on the 50th anniversary of the Japanese Society ofpsychopharmacology

My name is Tianmei Si from Peking University Institute of Mental Health. I am
currently

workingasthevicepresidentoftheAsianCollegeof

Neuropsychopharmacology(AsCNP). I want to express my sincerest congratulations tothe 50th anniversary of the Japan Society of Neuropsychopharmacology (JSNP).
At the start of the establishment, JSNP has played a leading role as thepsychopharmacological academic Society in the Asian area. These roles include initiating
the studies on the mechanism of psychotropic drugs, drug epidemiology, healtheconomics, translational medicine, and promoting rational pharmacotherapy for patientswith mental disorders in Japan and Asian Regions. In recent decades, globalization is oneof the essential activities of JSNP. JSNP keeps opening its arms to welcome international
scholars to participate in the conference, especially to encourage the young psychiatrists
from the world to communicate and share their thought on this platform. In 2007 and2008, I was honored to be invited by the organizing committee of 37th and 38th JSNP. I
gave the presentation in the symposium titled "internationalization of the new drug
clinical trials." From this conference, I realized this platform dramatically stimulates theresearch and development of new drug and translational medical science in Asian regions.
The other aspect of internationalization of JSNP is to unite Asian Colleagues toestablish the Asian College of Neuropsychopharmacology (AsCNP), and maintain theclose connection with international Neuropsychopharmacology Societies such as the31International College of Neuropsychopharmacology (CINP) (see photo 2 ) andAmerican College of Neuropsychopharmacology (ACNP) (See photo 3).
Professor Yamawaki, the past- president of JSNP (2010-2014), was elected as thefounding president of AsCNP. During his term, the first Scientific meeting of AsCNP
was held in Japan (Kyoto) in 2009, joint with the annual conference of JSNP. On theone hand, this platform allowed more participants from Asian countries and the world toshare the findings in the field of Neuropsychopharmacology. More than 30 participantsfrom China, and some colleagues gave inspiring speeches. On the other hand, thisplatform gained JSNP more reputation around the world. In recent years, JSNP,
associate with AsCNP, kept on strengthening collaboration with CINP, ACNP, andECNP.

(Photo2. Members from CINP/ JSNP/ AsCNP(photo 3, Members from JSNP/ CSP/ AsCNP in CANP

Executive Committee)

Congres)

In 2019, ten years later after the first congress of AsCNP, AsCNP congress was again
held in Japan joint with JSNP. Professor Kazutaka Ikeda is the present president. As amember of AsCNP and CSP, I impressed profoundly by the vision of innovation and therapid development of JSNP and AsCNP.

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In Chinese, there is a proverb called "海纳百川，有容乃大," which means thegrand ocean accommodates every river. I think it is the same spirit of JSNP,openness ofevery member that made today's JSNP great accomplishment.

(Photo 4, Members from AsCNP and JSNP in 6thAsCNP/JSNP

In the end, I would like to congratulate again for the 50th anniversary of JSNP, and I
wish JSNP to continue this greatness and march to the next milestone.
All the best,June 10, 2020
Beijing33

Letter for 50th Anniversary of JSNP
It is with great pleasure that I extend my warmest congratulations to The JapaneseSociety of Neuropsychopharmacology (JSNP) on its 50th anniversary. JSNP wasestablished in 1971, the earliest society specialized on mental health in Asia. It is alsoa pioneer in the world in building an active cross collaborations between basic
researchers and clinicians and promoting industry-government-academia
collaborations to facilitate new drug development. Moreover, JSNP has facilitatedacademic communications with other Asian countries including Korea, China, Taiwan,Indonesia, Singapore, Hong-Kong, Malaysia and others to form the AsCNP, the firstneuropsychopharmacology organization in the Asia. Since 2009, six biennial
meetings have been held to provide exchanges in research, clinical experience andeducation. Under the leadership of Professors Yamawaki and Ikeda, JSNP and AsCNP
have strengthened relationships to international organizations CINP, ECNP and ACNP.

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I am confident that with strong leadership, JSNP will achieve new heights in leading
partner Asian countries to improve care of patients with mental health disorders into
the years to come.

Sincerely yours,

Tung-Ping Su, MD
Professor Emeritus
National Yang-Ming University,
Taipei, Taiwan
Chief, Department of Psychiatry
Cheng-Hsin General Hospital
Taipei, Taiwan
President
AsCNP (2015, 2016)35

Letter for 50th anniversary of JSNP
Chay Hoon Tan, MD, PhD
President-Elect,
Asian College of Neuropsychopharmacology (AsCNP)
Associate Professor,
Department of Pharmacology,
Yong Loo Lin School of Medicine,National University of Singapore

Introduction
Research on Asian Prescription Pattern (www.REAP.asia) is the largest and the longest lasting
international collaborative research in psychiatry in Asia. In December 1999, Associate professor Tan
Chay Hoon organized the International Symposium on Neuro-psychopharmacology in Singapore withthe support from National University of Singapore (NUS) and Japan Society for the Promotion ofScience (JSPS). The symposium drew many psychiatrists and neuropsychopharmacologists from Asia
(photo1and 2). Prof N Shinfuku, Professor EH Kua and CH Tan proposed project with the aims to study
the prescription of psychotropic drugs in the large population of Asia, the clinical and adverse effects ofthe patients with psychiatric disorders and the factors associated with the prescription. The idea wastaken further and leading experts from six Asian countries agreed to carry out a census investigation oftreatment of schizophrenia in their countries. The study was completed in 2001 and it was a success inevery way – it produced useful data, it brought investigators from different countries of Asia together
into a collaborative network and important studies.

Major REAP symposia
Japan Society of Psychiatry and Neurology (JSPN) organized the 12th in Yokohama. It was the first
World Congress of Psychiatry (WPA) Congress held in Asia and attended by more than 6,000
participants from all over the world (photo 4). The findings of the first survey of REAP were reported inthe WPA symposium and it attracted many participants.
The results from the 2,398 prescription of inpatients with schizophrenia from 6 countries provided
evidence that prescription pattern differs greatly country to country. The findings led to subsequent36

surveys and the conclusive findings that prescription pattern is influenced by licensing policy and costrather than scientific data.
REAP continued to present evidence in various meetings in AsCNP, and WPA (see photos below)

Conclusion
1. There are many factors which decide the prescription habits of clinicians.
2. Evidence from the large scale surveys play a role in shaping the rational prescription of
psychotropic drugs of psychiatrists in countries.
3. Evidence from the surveys provided impetus for the introduction of several financial measures
to prevent irrational prescription in psychiatry in some countries.
4. Continued collaboration and presentation of findings provide evidence for change. This change
will be the strong advocate for the patients with mental illnesses.

1999 NUS Singapore (photo 1 and 2)

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2002 REAP Research Meeting at Kobe, Japan38

2002 World Psychiatric Association held in Yokohama, Japan (photo 4)2013 AsCNP in Beijing REAP members (photo 5)39

2015 March, 5th World Congress of Asian Psychiatry,Fukuoka Japan

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2015 Nov WPA REAP Symposium Taipei.

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REAP Review Meeting September 2016, Taipei

2017 AsCNP 2017, Bali, Indonesia (photo 6)42

2017 WPA 2017 Berlin, Germany (photo 7)

2018 Singapore, preparing for the 7th AsCNP conference

432019 AsCNP Fukuoka, Japan44

Letter for 50th anniversary of JSNP
I first learned about JSNP organization 25 years ago when I finished
my PhD in Hiroshima University.
At that time, I only knew JSNP at a glance as the organization that
focus mainly on neuropsychopharmacology field.
However in these last few decades, JSNP showed remarkableprogress in the member recruitment and several activities thatcarried out. JSNP also actively extent its collaboration both locallyand internationally. This is proven in 2017 that JSNP was able tocarried out its award ceremony in 5th ASCNP congress in Bali,Indonesia.

It is unmistaken that JSNP has many contributions
neuropsychopharmacology field in Japan and even all Asia.

in45

I wish we can improve our collaboration and it is very possible that
one day JSNP will be the front runner in neuropsychopharmacology
field in Asia or even in the rest of Globe.
In the end, congratulations and successon the 50thanniversary,
hopefully all the progress achieved may be beneficial for all mankind.
Thank you,
Andi Jayalangkara TANRA
Prof, Department of Psychiatry,
Universitas Hasanuddin, Makassar,
Indonesia
Chief Unit Research, Neurobehaviour
and Psychiatry, Faculty of Medicine,
Universitas Hasanuddin, Makassar,
Indonesia
Past-President of Asian College of Neuropsychopharmacology(AsCNP)
President-Elect of Indonesian Psychiatric Association (IPA)46

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