CURRICULUM VITAE(April 1, 2022)
Name:
Family name: Ishimoto
Given name: Takahiro
Sex:

Male

Date of Birth:
Place of Birth:
Marital Status:
Nationality:

20 October 1989
Fukui, Japan
SingleJapanese

Current Position:
Assistant professor (March, 2019 ~)Laboratory of Molecular Pharmacotherapeutics,
Faculty of Pharmacy,
Institute of Medical, Pharmaceutical and Health Sciences,
Kanazawa University
Present Address:
Faculty of Pharmacy,
Institute of Medical, Pharmaceutical and Health Sciences,
Kanazawa University
Kakuma-machi, Kanazawa 920-1192, Japan[TEL] +81-76-264-6302 [FAX] +81-76-264-6302[E-mail] ishimoto@p.kanazawa-u.ac.jp
Education:
University of Kanazawa, B.S. 2012 Pharmacy
University of Kanazawa, M.S. 2014 Pharmaceutical Sciences
University of Kanazawa, Ph.D. 2018 Pharmaceutical Sciences
Research Experience:(April, 2015 ~ March, 2017)
・Japan Society for the Promotion of Science (JSPS) Research Fellow

(April, 2018 ~ September, 2018)
・ Postdoctoral fellow (Division of Developmental Biology, Cincinnati
Children's Hospital Medical Center)(October, 2018 ~ February, 2019)
・Postdoctoral fellow (Neural Connectivity Development in Physiology andDisease Laboratory, Burke Neurological Institute)Society/Membership:(1) Japanese Society for Neurochemistry (JSN)(2) Japanese Pharmacological Society (JPS)(3) International Society for Neurochemistry (ISN)(4) Japanese Society of Neuropsychopharmacology (JSNP)(5) Pharmaceutical Society of Japan (PSJ)※
Publications (original articles):Corresponding author
1. Agustina R, Masuo Y, Kido Y, Shinoda K, Ishimoto T, Kato Y※. Identification ofFood-derived Isoflavone Sulfates as Inhibition Markers for Intestinal Breast Cancer
Resistance Proteins. Drug Metab Dispos, 49: 972-984.

2. Nishiyama M, Nakamichi N, Yoshimura T, Masuo Y, Komori T, Ishimoto T, MatsuoJI, Kato Y※. Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 andPotentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice. Neurochem Res,
45:2664-2678, 2020.
3. Nakamichi N, Nakao S, Nishiyama M, Takeda Y, Ishimoto T, Masuo Y, Matsumoto S,Suzuki M, Kato Y※. Oral Administration of the Food Derived Hydrophilic
Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice. Curr Mol
Pharmacol, 14:220-233, 2021.
4. Nakamichi N, Matsumoto Y, Kawanishi T, Ishimoto T, Masuo Y, Horikawa M, KatoY※. Maturational Characterization of Mouse Cortical Neurons Three-DimensionallyCultured in Functional Polymer FP001-Containing Medium. Biol Pharm Bull,
42:1545-1553, 2019.
5. Ishimoto T, Masuo Y, Kato Y, Nakamichi N※. Ergothioneine-induced neuronaldifferentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB
signaling in murine neural stem cells. Cell Signal, 53:269-280, 2019.
6. Ishimoto T, Nakamichi N※, Nishijima H, Masuo Y, Kato Y. Carnitine/Organic Cation
Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial
Cells. Neurochem Res, 43: 116-128, 2018.

7. Nakamichi N, Ishimoto T, Yamauchi Y, Masuo Y, Kato Y※. Screening to Identify
Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-SelectiveCytotoxicity. Biol Pharm Bull, 39: 1638-1645, 2016.
8. Nakamichi N, Nakayama K, Ishimoto T, Masuo Y, Wakayama T, Sekiguchi H, SutohK, Usumi K, Iseki S, Kato Y※. Food-derived hydrophilic antioxidant ergothioneine
is distributed to the brain and exerts antidepressant effect in mice. Brain and Behavior,
6: e00477, 2016.
9. Ben Said M, Grati M, Ishimoto T, Zou B, Chakchouk I, Ma Q, Yao Q, Hammami B,Yan D, Mittal R, Nakamichi N, Ghorbel A, Neng L, Tekin M, Shi XR, Kato Y,Masmoudi S※, Lu Z, Hmani M, Liu X※. A mutation in SLC22A4 encoding an organic
cation transporter expressed in the cochlea strial endothelium causes human recessive
non-syndromic hearing loss DFNB60. Hum Genet, 135: 513-524, 2016.
10. Naka K※, Jomen Y, Ishihara K, Kim J, Ishimoto T, Bae EJ, Mohney RP, Stirdivant
SM, Oshima H, Oshima M, Kim DW, Nakauchi H, Takihara Y, Kato Y, Ooshima A,Kim SJ※. Dipeptide species regulate p38MAPK-Smad3 signalling to maintainchronic myelogenous leukaemia stem cells. Nature Commun, 6: 8039, 2015.
11. Shimizu T, Kijima A, Masuo Y, Ishimoto T, Sugiura T, Takahashi S, Nakamichi N,
Kato Y※. Gene ablation of carnitine/organic cation transporter 1 reduces
gastrointestinal absorption of 5-aminosalicylate in mice. Biol Pharm Bull, 38: 774780, 2015.
12. Ishimoto T, Nakamichi N, Hosotani H, Masuo Y, Sugiura T, Kato Y※. Organic cationtransporter-mediated ergothioneine uptake in mouse neural progenitor cells
suppresses proliferation and promotes differentiation into neurons. PLoS One, 9:
e89434, 2014.
13. Nakamichi N, Shima H, Asano S, Ishimoto T, Sugiura T, Matsubara K, Kusuhara H,Sugiyama Y, Sai Y, Miyamoto K, Tsuji A, Kato Y※. Involvement of carnitine/organic
cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. JPharm Sci, 102: 3407-3417, 2013.
Publications (review articles):
1. Ishimoto T, Kato Y※. Ergothioneine in the brain. FEBS Lett, in press.
2. Ishimoto T, Kato Y※. Regulation of Neurogenesis by Organic Cation Transporters:
Potential Therapeutic Implications. Handb Exp Pharmacol 266: 281-300, 2021.
3. 石本尚大、加藤将夫※ 中枢神経系細胞に発現する薬物トランスポーターとその働き. 医学のあゆみ 271(1): 33-41, 2019.
4. 石本尚大、加藤将夫※ 薬物動態とは〜薬物の生体内動態と薬物速度論〜Clinical Calcium26(11)「骨粗鬆症治療薬の薬物動態と使用法〜薬物の生体内動態と薬物速度論〜」: 9-17,
2016.

Grants:2022 Mochida Memorial Foundation for Medical and Pharmaceutical Research2020 Grant-in-Aid for Scientific Research provided by the Ministry of Education,
Science and Culture of Japan (No. 20K15991)

2019

Grant-in-Aid for Scientific Research provided by the Ministry of Education,
Science and Culture of Japan (No. 19K23797)

2018“Overseas Postdoctoral Fellowship” from the Uehara Memorial
Foundation (April, 2018 ~ April, 2019)2015

Grant-in-Aid for Scientific Research provided by the Ministry of Education,
Science and Culture of Japan (No. 15J03940)

Awards:APSTJ , Global Education Seminar Presentation Award 2019