第 1 日目

12 月 1 日（水）シンポジウム第1日目12月1日（水）1AS-01Room 01 (Pacifico Yokohama Conference Center, 1F, Main Hall)

9:00-11:15【E】‘Messenger' RNA: Drug Target and Vaccine
Organizers：Akila Mayeda（Fujita Health University）
Adrian R. Krainer（Cold Spring Harbor Laboratory）

1AS-01-Introduction
Adrian Krainer（Cold Spring Harbor Lab.）

1AS-01-1

【9:00】【9:10】Development of new generation vaccines using nucleoside-modified mRNA
Norbert Pardi（Perelman Sch. of Med., Univ. of Pennsylvania）

1AS-01-2

【9:35】

Pyrrole-Imidazole Polyamides as artificial genetic switches

Hiroshi Sugiyama（Dept. of Chem., Grad. Sch. of Sci., Kyoto Univ.）

1AS-01-3

【9:50】

Boosted tumor immunogenicity by splicing modulation potentiates the response to immune checkpoint therapy

1 1
Shingo Matsushima1, Masahiko Ajiro1, Kenji Chamoto2, Tasuku Honjo2, Masatoshi Hagiwara（Dept. of Anat. & Dev. Biol., Grad. Sch.
2of Med., Kyoto Univ., Dept. of Immun. & Genomic Med., Grad. Sch. of Med., Kyoto Univ.）

1AS-01-4

【10:05】

Sequence-based design of small molecules targeting RNA structures to manipulate and study disease biology
Matthew D. Disney（Dept. of Chem., Scripps Research）

1AS-01-5

【10:30】A small molecule targeting UGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 31

Tomonori Shibata1, Konami Nagano2, Morio Ueyama3, Kensuke Ninomiya4, Tetsuro Hirose4, Yoshitaka Nagai3, Kinya Ishikawa5,
1 1
Gota Kawai2, Kazuhiko Nakatani（SANKEN, Osaka Univ., 2Fac. of Eng., Chiba Inst. of Tech., 3Sch. of Med., KINDAI Univ., 4FBS, Osaka
5
Univ., Tokyo Med. & Dent. Univ.）

1AS-01-6

【10:45】Splice-switching antisense oligonucleotide therapeutics for neurological conditions
Adrian R. Krainer（Cold Spring Harbor Lab.）

1AS-01-ConclusionAkila Mayeda（Fujita Health University）

1AS-02

Room 02 (Pacifico Yokohama Conference Center, 3F, 301)
Co-hosted by: A new foundation for primate developmental biology【11:10】
9:00-11:15【E】

Toward a new era for primate developmental biology
Organizers：Tomonori Nakamura（Kyoto University）
Yasuhiro Takashima（Kyoto University）

1AS-02-Introduction
Tomonori Nakamura（Kyoto University）

1AS-02-1

【9:00】【9:02】

A developmental coordinate of three-germ layer differentiation in primates
Tomonori Nakamura1,2（1WPI-ASHBi, Kyoto-U, 2Hakubi, Kyoto-U）

1AS-02-2

【9:20】

Cell Competition Constitutes a Barrier for Interspecies Chimerism

Jun Wu1,2（1Department of Molecular Biology, University of Texas Southwestern Medical Center, 2Hamon Center for Regenerative
Science and Medicine, University of Texas Southwestern Medical Center）

1AS-02-3

【9:50】

Generation of transgenic cynomolgus monkeys using piggyBac transposition

Tomoyuki Tsukiyama1,2（1Shiga Univ. of Medical Science, 2ASHBi, Kyoto University）

1AS-02-4

【10:08】

Genomic and epigenomic integrity controls during primate male germ cell development
Toshiaki Watanabe（CIEA・marmoset）

The 44th Annual Meeting of the Molecular Biology Society of Japan1

第 1 日目

1AS-02-5

12 月 1 日（水）【10:26】

Extrinsic factors promoting cortical expansion in primates

Jun Hatakeyama, Haruka Sato, Kenji Shimamura（IMEG, Kumamoto Univ.）

1AS-02-6

【10:56】

Modeling in vitro embryonic development using naive pluripotent stem cells
Yasuhiro Takashima（Kyoto Univ. CiRA）

1AS-02-Conclusion

【11:14】

Yasuhiro Takashima（Kyoto University）

1AS-03

9:00-11:15【E】

Room 03 (Pacifico Yokohama Conference Center, 3F, 302)

Mitochondria link higher-ordered biological functions and medical sciences
Organizers：Naotada Ishihara（Osaka University）
Kazuto Nakada（University of Tsukuba）

1AS-03-Introduction

【9:00】

Naotada Ishihara（Osaka University）

1AS-03-1

【9:05】

Mitochondrial dynamics in immunity, metabolism, differentiation, and ageing

Takaya Ishihara, Emi Ogasawara, Tatsuki Yasuda, Yuki Hanada, Naotada Ishihara（Dept. of Biol. Sci., Grad. Sch. of Sci. Osaka Univ.）

1AS-03-2

【9:30】

Mitochondrial tRNA modification and mitochondrial disease
Fanyan Wei（Dept. Modomics, IDAC, Tohoku Univ.）

1AS-03-3

【9:55】

Improvement of C. elegans sarcopenia and muscular dystrophy by suppressing mitochondrial Ca2+ influx

4 1
Atsushi Higashitani1, Mika Teranishi1, Takaaki Abe2, Yukihiko Kubota3, Takeshi Kobayashi（
Grad. Sch. of Life Sci., Tohoku Univ.,
23
4Grad. Sch. of Bioeng. / Med. Tohoku Univ., Coll. of Life Sci, Ritsumeikan Univ, Grad. Sch. of Med. Nagoya Univ.）

1AS-03-4

【10:20】Generation and characterization of novel trans -mitochondrial mice carrying a pathogenic mtDNA mutation

Haruna Tani1,2, Kaori Ishikawa1,3, Hiroaki Tamashiro1, Emi Ogasawara4, Fan-Yan Wei2, Takehiro Yasukawa5,6, Shigeru Matsuda2,5,
Akinori Shimizu7, Dongchon Kang5, Jun-Ichi Hayashi8, Kazuto Nakada1,3（1Grad. Sch. Life and Env. Sci., Univ. of Tsukuba, 2Dept.
Modomics, IDAC, Tohoku Univ., 3Faculty of Life and Env. Sci, Univ. of Tsukuba, 4Dept. of Biol. Sci., Grad. Sch. of Sci., Osaka Univ.,
5
Dept. CCLM, Kyushu Univ., 6Dept. of Path. and Onco., Facul. of Med., Juntendo Univ., 7Dept. of Microbiol. and Immunol., Sch. of Med.,
Fukuoka Univ. , 8TARA, Univ. of Tsukuba）

1AS-03-5

【10:45】Topics on therapeutics for mitochondrial diseases
Yu-ichi Goto（Nat. Cent. of Neurol. Psychiat. ）1AS-03-Conclusion
Kazuto Nakada（University of Tsukuba）

1AS-04

Room 04 (Pacifico Yokohama Conference Center, 3F, 303)

【11:10】
9:00-11:15【E】

The common mechanism for regulation of genome maintenance by DNA structural dynamics
Organizers：Kazutoshi Kasho（Kyushu University）
Tsutomu Katayama（Kyushu University）

1AS-04-Introduction
Kazutoshi Kasho（Kyushu University）

1AS-04-1

【9:00】【9:02】

Understanding eukaryotic DNA replication one molecule and one step at a time
Huilin Li（Van Andel Institute）

1AS-04-2

【9:26】

Dynamic nucleoprotein complexes and DNA structural changes supporting regulated replication initiation of the Escherichia
coli chromosome
Tsutomu Katayama1, Kenya Miyoshi1, Ryusei Yoshida1, Chuyuan Lu1, Lanyang Li1, Kazuma Korogi1, Yuka Tatsumoto1, Kosuke Ito1,
1 1
Hironori Kawakami1,2, Kazutoshi Kasho1, Shogo Ozaki（Dep. of Mol. Biol., Grad. Sch. of Pharm. Sci., Kyushu Univ., 2(Present) Fac. ofPharm. Sci., Sanyo-Onoda City Univ.）

2

第 44 回日本分子生物学会年会

第 1 日目

12 月 1 日（水）1AS-04-3

【9:47】

Association of Rif1 with nuclear membrane is essential for genome-wide replication timing regulation

Tomohiro Iguchi1, Sayuri Ito1, Naoko Kakusho1, Satoshi Yamazaki1, Asami Oji2, Rino Fukatsu1, Ichiro Hiratani2, Hiroyuki Sasanuma1,1 1
Hisao Masai（Genome Dynamics, Dept. of Basic Med. Sci., Tokyo Metro. Inst. Med. Sci., 2Lab. Develop. Epigen., RIKEN BDR)）

1AS-04-4

【10:08】

Mitochondrial DNA replication stalling enhances G-quadruplexes formation in cultured human cells
Sjoerd Wanrooij, Mara Doimo（Umeå University）

1AS-04-5

【10:32】

Possible mechanism of transcription-replication regulation at a replication origin of human mitochondrial DNA

Takehiro Yasukawa1, Shigeru Matsuda2, Masunari Nakayama3, Takashi Ishiuchi4, Yura Do3, Kazuto Nakada5, Kenji Ichiyanagi6,
3 1
Hiroyuki Sasaki4, Dongchon Kang（
Dept. Pathol. Oncol., Sch. Med., Juntendo Univ., 2IDAC, Tohoku Univ., 3Dept. CCLM, Grad. Sch.,
4Med., Kyushu Univ., Div. Epigen. Dev., Med. Inst. Bioreg, Kyushu Univ., 5Fac. Life Environ. Sci., Univ. of Tsukuba, 6Grad. Sch. Bioagri.
Sci., Nagoya Univ.）

1AS-04-6

【10:53】

A novel regulatory mechanism of PrimPol-dependent mitochondrial genome maintenance by an unique multi-functional
protein PolDIP2

Kazutoshi Kasho1,2, Anais Lamy1, Andreas Berner1, Tran Nguyen1, Gorazd Stojkovic1, Cristina Velazquez-Ruiz3,
Maria I. Martinez-Jimenez3, Mara Doimo1, Timothee Laurent1, Aldo E. Perez-Rivera3, Ronnie Berntsson1, Luis Blanco3,1 1
Sjoerd Wanrooij（Dept. of Med. Biochem. and Biophys., Umea Univ., 2Present address; Dept. of Mol. Biol., Grad. Sch. of Pharm. Sci.,
3Kyushu Univ. Centro de Biologia Molecular Severo Ochoa）

1AS-04-Conclusion
Tsutomu Katayama（Kyushu University）

1AS-05

Room 05 (Pacifico Yokohama Conference Center, 3F, 304)

【11:14】9:00-11:15【E】

Brain functions enhanced by intercellular communication: new-found reciprocity of astrocytes and neurons
Organizers：Nariko Arimura（National Center of Neurology and Psychiatry）
Tetsuya Takano（Keio University）

1AS-05-IntroductionNariko Arimura（National Center of Neurology and Psychiatry）

1AS-05-1

【9:00】【9:03】

Molecular Interactions between Astrocytes and Purkinje Cells: Regulation of Synaptic Localization of GLAST andSynaptogenesis
Nariko Arimura（Dept. of Biochem. & Cell. Biol., NCNP）

1AS-05-2

【9:23】

Manipulation tool developments to study behavioral consequences of astrocyte signaling in vivo
Jun Nagai（RIKEN Center for Brain Science, Lab for Glia-Neuron Circuit Dynamics）

1AS-05-3

【9:48】

Astrocyte regulation of neuronal synapses
Nicola J Allen（Salk Institute）

1AS-05-4【10:18】

A specific cell-type interface proteomic approach Split-TurboID reveals astrocytic control of inhibition in vivo
Tetsuya Takano（Department of Neurophysiology, Keio University School of Medicine）

1AS-05-5

【10:43】

Adult network remodeling by reactive astrocytes

Schuichi Koizumi1,2（1Dept Neuropharmacol, Interdisc Grad Sch Med, Univ Yamanashi, 2Yamanashi GLIA Center, Univ Yamanashi）

1AS-05-ConclusionTetsuya Takano（Keio University）

The 44th Annual Meeting of the Molecular Biology Society of Japan【11:13】3

第 1 日目

1AS-16

Room 16 (Pacifico Yokohama Conference Center, 5F, 502)
Co-hosted by: Grant-in Aid for Scientific Research on Innovative Area Replication of Non Genome

12 月 1 日（水）9:00-11:15【E】

Chromosome, chromatin, and nuclear dynamics in sexual reproduction
Organizers：Kei-ichiro Ishiguro（Kumamoto University）
Satoshi Namekawa（University of California, Davis）

1AS-16-1

【9:00】

Polycomb establishes the oocyte epigenome to produce ovarian reserve
Satoshi Namekawa（Dept. of Mol. Genet. & Microbiol.）

1AS-16-2

【9:19】

Novel mRNA recognition and stability control mechanism essential for germ cell development

Masashi Yamaji1, Masataka Suzawa2, Misaki Yamaji1, Alexis Jacob2, Wataru Horikawa1, Byungil Kim3, Ascano Manuel3,2 1
Markus Hafner（Div. Rep. Sci. & Human Gen., CCHMC, 2Lab. Mus. Stem Cells Gene Reg., NIH/NIAMS, 3Dept. Biochem., Sch. Med.,
Vanderbilt Univ.）

1AS-16-3

【9:38】

Identification of meiosis-required genes using CRISPR/Cas9 and their functional analysis

Seiya Oura1,2, Masahito Ikawa1,2,3（1Research Institute for Microbial Diseases, Osaka University, 2 Graduate School of PharmaceuticalSciences, Osaka University, 3The Institute of Medical Science, The University of Tokyo）

1AS-16-4

【9:57】

Sexually different mechanisms of meiotic cell cycle in mammalian germ cells

Kei-ichiro Ishiguro（Institute of Molecular Embryology and Genetics, Kumamoto University）

1AS-16-5

【10:16】

Investigation of human sperm chromatin heterogeneity and sperm quality using ATAC-seq

1 1
Yoshinori Makino1, Masashi Hada1, Satoshi Kaneko2, Yuki Okada（IQB, Univ. of Tokyo, 2Tokyo Dent. Col., Ichikawa Gen. Hosp.）

1AS-16-6

【10:35】NANOS2-mediated cell cycle arrest as a first step of germ cell masculinization

1 1
Yumiko Saga1, Ryuki Shimada2, Takamasa Hirano（Mammalian Development Laboratory, National Institute of Genetics, 2Departmentof Chromosome Biology, Kumamoto University,）

1AS-16-7

【10:55】

Molecular network regulating the epigenetic program of mammalian oocytes
Hiroyuki Sasaki（Med. Inst. Bioreg., Kyushu Univ.）

1AS-17

Room 17 (Pacifico Yokohama Conference Center, 5F, 503)

9:00-11:15【E】

Data science and machine learning: Tackling the Noise and Heterogeneity of the Real World
Organizers：Eiryo Kawakami（RIKEN）
Shinya Kuroda（The University of Tokyo ）1AS-17-Introduction

【9:00】

Eiryo Kawakami（RIKEN）1AS-17-1

【9:02】

Methods for 3D reconstruction of histology sections at single-cell resolution

Josephine Galipon1,2,3（1Grad. Sch. of Media and Governance, Keio Univ., 2Inst. for Adv. Biosciences, Keio Univ., 3Neurosc. Inst., Grad.
Sch. of Sci., Nagoya Univ.）

1AS-17-2

【9:24】

Introduction to tensor packages to handle heterogeneous and multi-dimensional data structures
Koki Tsuyuzaki（RIKEN）

1AS-17-3

【9:46】

Machine learning for molecular graph representations and geometries
Ichigaku Takigawa1,2（1RIKEN AIP, 2WPI-ICReDD, Hokkaido Univ.）

1AS-17-4

【10:08】

Towards an Integrated Use of Medical Knowledge Representation and Clinical Real-World Data
Takeshi Imai（CDBIM, Grad. Sch. of Med., Univ. of Tokyo）

4

第 44 回日本分子生物学会年会

第 1 日目

12 月 1 日（水）1AS-17-5

【10:30】Comparative transomic analysis of glucose-responsive regulation of liver metabolism in obese ob/ob and wild-type mice

Toshiya Kokaji1, Atsushi Hatano2, Yuki Ito3, Katsuyuki Yugi4,5, Miki Eto6, Keigo Morita6, Satoshi Ohno6, Masashi Fujii7,Ken-ichi Hironaka6, Riku Egami8, Akira Terakawa6, Takaho Tsuchiya9,10, Haruka Ozaki9,10, Hiroshi Inoue11, Shinsuke Uda3,Hiroyuki Kubota3, Yutaka Suzuki8, Kazutaka Ikeda12, Makoto Arita4,13,14, Masaki Matsumoto2, Keiichi I. Nakayama15, Akiyoshi Hirayama5,Tomoyoshi Soga5, Shinya Kuroda6,8（1Data Science Center, Nara Inst. of Sci. and Tech., 2Grad. Sch. of Med. and Dent., Niigata Univ.,
3
Center for Transomics Med., Med. Inst. of Bioreg., Kyusyu Univ., 4Div. of Disease Syst. Biol., RIKEN for Integrative Med. Sci., 5Inst.
for Adv. Biosci., Keio Univ., 6Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo, 7Dept. of Math. and Life Sci., Grad. Sch. of Integrated
Sci. for Life, Hiroshima Univ., 8Dept. of Comp. Biol. and Med. Sci., Grad. Sch. of Frontier Sci., Univ. of Tokyo, 9Faculty of Med., Univ.
of Tsukuba, 10Center for AI, Univ. of Tsukuba, 11Innov. Integ. Bio. Core, Inst. for Front. Sci. Init. Kanazawa Univ., 12Clinic. Omics Unit,Kazusa DNA Research Inst., 13Grad. Sch. of Med. Life Sci., Yokohama City Univ, 14Faculty of Pharm., Keio Univ., 15Dept. of Mol. andCell. Biol., Med. Inst. of Bioreg., Kyusyu Univ.）

1AS-17-6

【10:52】Mathematical methods and machine learning meet real-world data to stratify patients and predict disease onset andprognosis
Tetsuo Ishikawa1, Eiryo Kawakami1,2（1ADSP, R-IH, RIKEN, 2Dept. of AI Med., Grad. Sch. of Med., Chiba Univ.）

1AS-17-ConclusionShinya Kuroda（The University of Tokyo ）1PS-16

Room 16 (Pacifico Yokohama Conference Center, 5F, 502)

【11:14】
15:45-18:00【E】

Biodiversity for Exciting Discoveries
Organizer：Tetsuya Higashiyama（The University of Tokyo / Nagoya University）

1PS-16-Introduction
Tetsuya Higashiyama（The University of Tokyo / Nagoya University）

1PS-16-1

【15:45】【15:55】Investigation of the mechanisms underlying delayed aging and cancer-resistance in the longest-lived rodent, the naked
mole-rat
Kyoko Miura（Dept of Aging and Longevity Research, Faculty of Life Sci, Kumamoto Univ.）

1PS-16-2

【16:25】How do axolotls regenerate the right amount of tissue?
Elly Tanaka（Institute of Molecular Pathology）

1PS-16-3

【16:55】

Dark energy ecosystem predicted and not predicted by chemical disequilibrium
Ken Takai（X-STAR, JAMSTEC）

1PS-16-4

【17:25】A Role for Epigenetic Variation in Plant Ecology and Evolution

Rolf Baumberger, Ueli Grossniklaus（Dept. Plant and Microbial Biol. & Zürich-Basel Plant Science Center, University of Zürich）

1PS-16-Discussion
1PS-17

Room 17 (Pacifico Yokohama Conference Center, 5F, 503)

【17:55】
15:45-18:00【E】

RNA in Nuclear Architecture and Chromatin Organization
Organizers：Hitoshi Kurumizaka（The University of Tokyo）
Yuka Iwasaki（Keio University）

1PS-17-1

【15:45】

Nuclear Architectural Regulation by Piwi-piRNAs

Yuka Iwasaki（Dept. Mol. Biol., Keio Univ. Sch. of Med.）

1PS-17-2

【16:07】The endoribonuclease SCHLAFEN9 enforces retrotransposon silencing

Mathilde Gauchier, Jerome Dejardin（Institute of Human Genetics CNRS UMR9002）

1PS-17-3

【16:32】

Architectural roles of noncoding RNAs in formation and function of nuclear bodies

1 1
Tetsuro Hirose1,2, Tomohiro Yamazaki1, Kensuke Ninomiya（FBS, Osaka Univ., 2Grad. Sch. of Sci, Osaka Univ.）

The 44th Annual Meeting of the Molecular Biology Society of Japan5

第 1 日目

1PS-17-4

12 月 1 日（水）【16:54】

Biomolecular Condensates: from Genome Regulation to Disease Biology
Hiroshi I. Suzuki（Div. Mol. Onco., Nagoya Univ. Grad. Sch. of Med.）

1PS-17-5

【17:16】Chromatin accessibility and transcriptional activities
Yusuke Miyanari（NanoLSI, CRI, Kanazawa U.）

1PS-17-6

【17:38】Structural and biochemical studies of nucleosome transcription in the presence of nuclear co-factors
Hitoshi Kurumizaka（Lab. of Chromatin struct. funct., IQB, Univ. of Tokyo）

6

第 44 回日本分子生物学会年会