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Safety Data Sheet
1. Chemical product and company identification
Product name

: N-METHYL-2-PYRROLIDINONE

Company information
Name of manufacturer
Address
Name of section
Telephone number
Facsimile number
Mail address
Reference No： KANTO CHEMICAL CO., INC.
： 2-1, Nihonbashi, Muromachi 2-Chome, Chuo-Ku, Tokyo, 103-0022, Japan： Electronic materials division technical department： +81-3-6214-1080： +81-3-3241-1043： el-info@kanto.co.jp: GE00039 1.3

Recommended uses andrestrictions: Electronic chemicals

2. Hazards identification
GHS classification
Health hazards

Skin corrosion/irritation

Category 2

Serious eye damage/eyeirritation

Category 2A

Reproductive toxicity

Category 1BSpecific target organ toxicity(single exposure)

Category 3 (narcosis)

Specific target organ toxicity(repeated exposure)

Category 2 (nervous system, lung, liver, bonemarrow)

Hazardpictograms

Signal word:

DangerHazard statements:

Causes skin irritation
Causes serious eye irritation
May cause drowsiness or dizziness
May damage fertility or the unborn child
May cause damage to organs (nervous system, lung, liver, bonemarrow) through prolonged or repeated exposure

Prevention:

Do not handle until all safety precautions have been read andunderstood.
Do not breathe mist/vapors.
Wash hands, forearms and face thoroughly after handling.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/faceprotection.

Response:

IF ON SKIN: Wash with plenty of water.
IF INHALED: Remove person to fresh air and keep comfortable forbreathing.

Precautionary statements

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IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER or doctor if you feel unwell.
Get medical advice/attention if you feel unwell.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
Storage:

Store in a well-ventilated place. Keep container tightly closed.
Store locked up.

Disposal:

Dispose of contents/container to hazardous or special waste
collection point, in accordance with local, regional, national
and/or international regulation.

3. Composition/information on ingredients
Distinction of substance ormixture:

Substance

Synonyms:

NMP, 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone

Chemical name
N-Methyl-2pyrrolidinone

Concentration (%)
min. 99.5

FormulaCH3NC4H6O

TSCA
ListedEC-No.
212-828-1

CAS RN
872-50-4

4. First aid measures
First aid measures
First-aid measures afterinhalation:

Remove the victim to fresh air, and make him blow his nose andgargle.

First-aid measures after skincontact:

Wash the affected areas under running water.

First-aid measures after eye
contact:

Wash the affected areas under running water for at least 15
minutes. Get medical treatment.

First-aid measures afteringestion:

The chemical is volatile. Do not induce vomiting because it
increases the risk of aspiration into the lungs. Get medical
attention immediately. If necessary, rinse mouth with water.

Personal Protection in FirstAid and Measures:

Rescuers should wear proper protective equipment like rubber
gloves, goggles.

Suitable extinguishing media:

Water, dry chemical powder, carbon dioxide, dry sandUnsuitable extinguishing media

:

None

Firefighting instructions:

Move containers from fire area if it can be done without risk, if
not possible, apply water from a safe distance to cool andprotect surrounding area.

5. Fire fighting measures

Fight fire from windward.
Dry chemical powder, carbon dioxide or dry sand should be used
for small fires. Foam extinguisher is effective for a large scale
fire.
Personal protection (Emergency:

Wear breathing apparatus.

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response)

6. Accidental release measures
Personal Precautions, Protective Equipment and Emergency Procedures
General measures:

Wear proper protective equipment and avoid contact with skin andinhalation of vapor. Conduct operations from upwind and evacuate
people downwind. Remove all sources of ignition. Keep away
personnel except for authorized ones from spillage area bystretching ropes.

:

Attention should be given to avoid discharge of spilled productinto rivers and resulting environmental damage. When diluting
spill with large amounts of water, discharge of untreatedwastewater into the environment must be avoided.

Environmental precautions
Environmental precautions

Methods and Equipment for Containment and Cleaning up
For containment:

Absorb spill with inert material （e.g, diatomaceous earth,sand） and flush spillage area with copious amounts of water.

Prevention Measures for
Secondary Accidents:

Remove nearby sources of ignition and prepare extinguishingmedia.

Technical measures:

Wear proper protective equipment to avoid contact with skin or
inhalation of vapor. Fire is strictly prohibited.

Precautions for safe handling:

7. Handling and storage
Handling

Ventilate well at working places.
Use with an enclosed system or a local exhaust ventilation. Use
in well-ventilated areas.
Do not allow contact with oxidizing substances.
Storage
Storage conditions:

Store the bottle tightly closed in a cool, dark place because thesubstance is hygroscopic.

Material used inpackaging/containers:

Glass, stainless steel.
Do not use polyvinyl chloride resin, polystyrene.

8. Exposure controls / Personal protection equipment
ACGIH TWA

Not established

Appropriate engineering
controls
Protective equipment: Use with an enclosed system or a local exhaust ventilation.

Respiratory protection: If necessary, wear chemical cartridge respirator with an organic
vapor cartage

Hand protection: Impervious protective gloves

Eye protection: Safety goggles

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9. Physical and chemical properties
Physical state: LiquidColor: Colorless - pale yellow

Odor: Amine likepH: No data available

Melting point: -24.4 °C

Freezing point: No data available

Boiling point: 202 °C

Flash point: 95 °C

Auto-ignition temperature: 346 °C

Decomposition temperature: No data available

Flammability: Flammable

Vapor pressure: 0.32 hPa (20℃)

Relative density: No data available

Density: 1.027 g/cm³ (25℃)

Relative gas density: 3.4Solubility: Water: Miscible. Organic solvents: Readily soluble in ethanol,chloroform, diethylether, etc.
: -0.54

Partition coefficient noctanol/water (log Pow)
Explosive limits (vol %): 0.9 – 3.9 vol %Viscosity, kinematic:: 1.84 mm²/s (25℃)

Particle characteristics: No data available

10. Stability and reactivity
Reactivity: May react with oxidizing substances.

Chemical stability: Stable under normal conditions.

Possibility of hazardous
reactions: Stable under normal conditions of use.

Conditions to avoid: Light, heat.

Incompatible materials: Oxidizing substances.

Hazardous decomposition
products: Carbon monoxide, nitrogen oxides.

11. Toxicological information
Acute toxicity (oral)
Acute toxicity (dermal)
Acute toxicity (inhalation)

Acute toxicity (mist) Description: No classification
rat LD50=3500mg/kg: No classification
rabbit LD50=6000mg/kg: No classification (gas)Classification not possible (vapor)
No classification (dust, mist): In rats that underwent head-only inhalation exposure (4 hours),
mortality was not observed at 5.1mg/L. Based on the saturated vapor
pressure concentration of approximately 1.7mg/L, the tests were
thought to be conducted under the mist state. Thus, the substance
was not classified.

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Skin corrosion/irritation:

Serious eye damage/irritation:

Respiratory sensitization
Skin sensitization::

Germ cell mutagenicity:

Carcinogenicity:

Causes skin irritation
There was a description that in humans (n=50) who repeatedly
received 24-hour patch tests on scratched skin for 15 times, slightto moderate temporary irritation was induced, and similarly, thesubstance caused skin irritation and contact dermatitis in humans.
In rabbit Draize tests, slight erythema (Draize score=0.5
equivalent to Not classified) was observed and in topical tests inwhich guinea pigs were treated with an aqueous solution containing
the substance, slight erythema (shown in 2 out of 10 treated guineapigs) was observed only at 50% solution. However, application of
the substance to the skin of rabbits for 5 to 15 minutes caused
severe erythema. Taking the skin irritation potential to humans
into account, it was classified into category 2.
Causes serious eye irritation
The substance has been documented to have effects on humans in suchforms as severe eye irritation and chronic eye irritation. In
Draize tests on rabbits, corneal clouding, iritis, andconjunctivitis were observed, and these symptoms disappeared within
21 days. Also, in another test using rabbits, corneal clouding,redness, and swelling were observed, and these symptoms continued
even after 8 days. Furthermore, in other rabbit tests, thesubstance was documented to cause moderate eye irritation. Based onthese effects observed in animals and humans, it was classified
into category 2A.
Classification not possible
Classification not possible
In a guinea pig sensitization test, no sensitization was observed.
Fifty humans, who repeatedly received 24-hour patch tests on
scratched skin 15 times, showed no signs of sensitization. In bothcases, the details of test conditions are unknown. Meanwhile,
workers occupationally exposed to the substance developed contact
dermatitis and skin symptoms. Based on the above information, theclassification was not possible.
No classification
Negative results in micronuclei test using rats and chromosome
aberration test using Chinese hamster. Ames tests also yielded
negative results.
Classification not possible
There is no human data on carcinogenicity. Animal studies haveshown that in 2-year exposure tests of carcinogenicity byinhalation route and oral route (feeding administration) in rats,
no evidence of tumor induction was found. Meanwhile, in 18-month
exposure tests of carcinogenicity by oral route (feedingadministration) in mice, hepatocellular carcinoma or hepatocellularadenoma were noted in male mice, increase in liver foci of cellularalteration was noted in male and female mice, which suggests
increases in peroxisome proliferating action or cell proliferation
effect as mechanism of the liver tumor in mice. As mentioned above,
conflicting results among animal species were obtained. Moreover,there is no classification results on carcinogenicity byinternational organizations. Thus, the classification is notpossible because of insufficient data.

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Reproductive toxicity:

STOT-single exposure:May damage fertility or the unborn childIn reproductive toxicity tests by oral and inhalation routes inrats, there were no adverse effects on fertility of parent animals
even at dosing levels toxic to parent animals. However, indevelopmental toxicity tests by oral route in pregnant rats andrabbits during organogenesis, developmental effects including
skeleton malformation in fetuses were observed at dosing levels
toxic to dams. Skeleton malformation, which is also found in rats
on dermal route, is fetal evidence seen at doses that causesmaternal toxicity such as suppression of body weight gain. However,skeleton malformation induction was judged to be evidence tosuggest serious reproductive toxicity effects of the substance,
taking into account description that fetotoxicity and malformation
are not secondary effects of maternal toxicity. Thus, the substancewas classified into category 1B.
May cause drowsiness or dizziness
The substance causes respiratory tract irritation in animals. In
humans, the substance causes severe eye irritation and headache,but in inhalation tests using volunteers there is no report ofrespiratory tract irritation. Animal studies have shown that
inhalation exposure test in rats at 5,100 mg/m3 (5.1 mg/L) (mixtureof vapor and aerosol) caused no deaths. During exposure, tachypnea,irregular respiration, breathlessness, and decline in pain reflex
were noted, and tachypnea was noted after exposure. In oral
administration tests in rats and mice at 519 mg/kg, incoordination
was reported. Based on the above information, the substance wasjudged to have no respiratory tract irritation in humans. Decline
in pain reflex and incoordination in rats suggests anestheticactions. Thus, the substance was classified into category 3(narcosis).

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STOT-repeated exposure:May cause damage to organs (nervous system, lung, liver, bonemarrow) through prolonged or repeated exposure
There is no human data. Toxicity of inhalation exposure is strongly
affected by proportion of aerosol to vapor and exposure range(head-only exposure or whole-body exposure). Regarding experimental
animals, in 2-week inhalation toxicity test in rats, head-only
exposure at 1,000 mg/m3 (0.11 mg/L as guidance value) caused onlyslight nasal irritation, but whole-body exposure at the same
concentration (coarse droplets and high relative humidity) caused
massive mortality (8-9/10 subjects), apathy, irregular respiration,
convulsions, tremors, decreases in body weight/weight gain,
irritation in the nasal region, and in dead animals, severe adverse
effects on organs and tissues (congestion of almost all organs,
lymphocyte depletion and necrosis of spleen, panmyelophthisis,
gelatinous bone marrow, and cell depletion of bone marrow,pulmonary edema and multiple purulent pneumonia of lung, necrotic
degeneration of liver, ulcer of glandular stomach, and increased
adrenal gland weight) were noted. In a 4-week repeated inhalation
toxicity test in rats (exposure was cancelled on day 10 at highdosing levels due to massive mortality), at 1,000 mg/m3 (0.11 mg/L
as guidance value), death or sacrifice (13/30), lethargy, irregularrespiration, dyspnea, and in death animals, edema and congestion oflung, bone marrow hypoplasia, atrophy and/or necrosis of the thymus
gland, spleen, and lymph node (lymphoid tissue) were observed. The
maximum vapor phase at room temperature is 1318 mg/m3 in dry air(0% relative humidity), 412 mg/m3 at normal humidity (60% relativehumidity), and 0 mg/m3 in wet air (100% relative humidity). Because
it is considered that above-mentioned 1,000 mg/m3 is not vapor, but
contains mist, the substance was classified into category 2(nervous system, lung, liver, bone marrow) based on classificationof mist.

Aspiration hazard:

Classification not possible

12. Ecological information
Ecotoxicity
Aquatic acute
Aquatic chronic: No classification
Daphnia magna EC50>1000mg/L/24h: No classification

Persistence and degradability
Readily biodegradable
BOD : 73% (NO2), 94% (NH3)
Bioaccumulative potential
Low bioconcentrationlog Pow : -0.54
Mobility in soilHigh mobility
Koc : 4.6
Hazardous to the ozone layerOzone: Classification not possible

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13. Disposal considerations
Ecological waste information: Burn in a chemical incinerator equipped with an afterburnerand a scrubber. Or entrust approved waste disposal companies
with the disposal.

Contaminated container andpackaging: In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea(IMDG)
UN-No. (IMDG)
Proper Shipping Name (IMDG)
Packing group (IMDG)
Transport hazard class(es)(IMDG)Air transport(IATA)
UN-No. (IATA)
Proper Shipping Name (IATA)
Packing group (IATA)
Transport hazard class(es)(IATA)::::

Not applicableNot applicableNot applicableNot applicable::::

Not applicableNot applicableNot applicableNot applicable

Marine pollutant: Not applicable
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC CodePollutant category:Y

15. Regulatory information
Regulatory information with regard to this substance in your country or region should be examined byyour own responsibility.

16. Other information
Data sources: Dictionary of Organic Compounds, The society of Synthetic
Organic Chemistry, Kodansha Ltd.（1985）.
Solvents Handbook, T, Asahara el, Kodansha Scientific Ltd.
（1976）.
Dangerous Properties of Industrial Materials,6th ed.
N.I.Sax Van Nostrand Reinhold Company（1984）.
Handbook of 17322 Chemical Products, The Chemical Daily Co.
（2022）.
NITE Chemical Risk Information Platform (NITE-CHRIP), National
Institute of Technology and Evaluation.

The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully.The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements.The information herein is only provision of information, andit does not represent a guarantee the properties of the product.The Safety Data Sheet(SDS) isprepared based on JIS Z7253.