<< GE00029 CYCLOHEXANONE >>

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Issue date: 12/26/2007
Revision date: 6/18/2024

Safety Data Sheet
1. Chemical product and company identification
Product name

: CYCLOHEXANONE

Company information
Name of manufacturer
Address
Name of section
Telephone number
Facsimile number
Mail address
Reference No： KANTO CHEMICAL CO., INC.
： 2-1, Nihonbashi, Muromachi 2-Chome, Chuo-Ku, Tokyo, 103-0022, Japan： Electronic materials division technical department： +81-3-6214-1080： +81-3-3241-1043： el-info@kanto.co.jp: GE00029 1.2

Recommended uses andrestrictions: Electronic chemicals

2. Hazards identification
GHS classification
Physical hazards

Flammable liquids

Category 3

Health hazards

Acute toxicity (oral)

Category 4

Acute toxicity (dermal)

Category 3

Acute toxicity(inhalation:vapors)

Category 3

Skin corrosion/irritation

Category 2

Serious eye damage/eye
irritation

Category 2A

Skin sensitization

Category 1

Germ cell mutagenicity

Category 2

Reproductive toxicity

Category 2

Specific target organ toxicity(single exposure)

Category 1 (respiratory organs)

Specific target organ toxicity(single exposure)

Category 2 (central nervous system)

Specific target organ toxicity(single exposure)

Category 3 (narcosis)

Specific target organ toxicity(repeated exposure)

Category 1 (central nervous system, bone)

Hazardpictograms

Signal word:

DangerHazard statements:

Flammable liquid and vapor
Harmful if swallowed
Toxic in contact with skin or if inhaled
Causes skin irritation
May cause an allergic skin reaction

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Causes serious eye irritation
May cause drowsiness or dizziness
Suspected of causing genetic defects
Suspected of damaging fertility or the unborn childCauses damage to organs (respiratory organs)
May cause damage to organs (central nervous system)
Causes damage to organs (central nervous system, bone) throughprolonged or repeated exposure
Precautionary statements
Prevention:

Do not handle until all safety precautions have been read andunderstood.
Keep away from heat, hot surfaces, sparks, open flames and otherignition sources. No smoking.
Keep container tightly closed.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use only non-sparking tools.
Take action to prevent static discharges.
Do not breathe mist/vapors.
Wash hands, forearms and face thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Contaminated work clothing should not be allowed out of theworkplace.
Wear protective gloves/protective clothing/eye protection/faceprotection.

Response:

IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell.
IF ON SKIN: Wash with plenty of water.
IF ON SKIN (or hair): Take off immediately all contaminatedclothing. Rinse skin with water .
IF INHALED: Remove person to fresh air and keep comfortable forbreathing.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
IF exposed or concerned: Call a POISON CENTER or doctor.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER or doctor.
Call a POISON CENTER or doctor if you feel unwell.
Get medical advice/attention if you feel unwell.
Rinse mouth.
If skin irritation or rash occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Take off immediately all contaminated clothing and wash it before
reuse.
Take off contaminated clothing and wash it before reuse.

Storage:

Store in a well-ventilated place. Keep container tightly closed.
Store in a well-ventilated place. Keep cool.
Store locked up.

Disposal:

Dispose of contents/container to hazardous or special waste
collection point, in accordance with local, regional, national
and/or international regulation.

3. Composition/information on ingredients
Distinction of substance or:

Substance<< GE00029 CYCLOHEXANONE >>

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mixtureSynonyms
Chemical name
Cyclohexanone:

Ketocyclohexane

Concentration (%)
min. 99.0

FormulaC6H10O

TSCA
ListedEC-No.
203-631-1

CAS RN
108-94-1

4. First aid measures
First aid measures
First-aid measures after
inhalation:

Remove victim to fresh air and keep at rest in a position
comfortable for breathing. Immediately get medical treatment.

First-aid measures after skincontact:

Wash the affected areas under running water.

First-aid measures after eye
contact:

Wash the affected areas under running water for at least 15
minutes. If necessary, get medical treatment.

First-aid measures afteringestion:

The chemical is volatile. Do not induce vomiting because it
increases the risk of aspiration into the lungs. Get medical
attention immediately. If necessary, rinse mouth with water.

Personal Protection in FirstAid and Measures:

Rescuers should wear proper protective equipment like rubber
gloves, goggles.

Suitable extinguishing media:

Dry chemical, CO2, dry sand, or alcohol-resistant foam

Unsuitable extinguishing media:

Water spray, Foam extinguisher

Firefighting instructions:

Move containers from fire area if it can be done without risk, if
not possible, apply water from a safe distance to cool andprotect surrounding area.

5. Fire fighting measures

Fight fire from windward.
Dry chemical powder, carbon dioxide or dry sand should be used
for small fires. Alcohol-resistant foam extinguisher is effective
for a large scale fire.
Personal protection (Emergency
response):

Wear breathing apparatus.

6. Accidental release measures
Personal Precautions, Protective Equipment and Emergency Procedures
General measures:

Wear proper protective equipment and avoid contact with skin andinhalation of vapor. Conduct operations from upwind and evacuate
people downwind. Remove all sources of ignition. Keep away
personnel except for authorized ones from spillage area by
stretching ropes.

:

Attention should be given to avoid discharge of spilled productinto rivers and resulting environmental damage. When diluting
spill with large amounts of water, discharge of untreatedwastewater into the environment must be avoided.

Environmental precautions
Environmental precautions

Methods and Equipment for Containment and Cleaning up
For containment:

Absorb spill with inert material （e.g, diatomaceous earth,sand） and flush spillage area with copious amounts of water.

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Prevention Measures for
Secondary Accidents:

Remove nearby sources of ignition and prepare extinguishingmedia.

:

Wear proper protective equipment to avoid contact with skin or
inhalation of vapor. Fire is strictly prohibited.

7. Handling and storage
Handling
Technical measures

Ventilate well at working places.
Precautions for safe handling:

Use with an enclosed system or a local exhaust ventilation. Use
in well-ventilated areas.
Do not allow contact with oxidizing substances.

Storage
Storage conditions:

Store in a dark, cool place and tightly closed.
Keep out of direct sunlight in a place below 40℃.

Material used inpackaging/containers:

Glass, stainless steel.
Do not use vinyl chloride resin, acrylic resin, polystyrene etc.

8. Exposure controls / Personal protection equipment
ACGIH TWA

20 ppmACGIH STEL

50 ppmRemark (ACGIH)

Skin

Appropriate engineering
controls
Protective equipment: Use with an enclosed system or a local exhaust ventilation.

Respiratory protection: Chemical cartridge respirator with an organic vapor cartage orairline respirator

Hand protection: Impervious protective gloves

Eye protection: Safety goggles

Skin and body protection: Protective clothing, protective boots

9. Physical and chemical properties
Physical state: Liquid

Color: Colorless - pale yellow

Odor: Camphor like odor

pH

: No data available

Melting point: -45 °C

Freezing point: No data available

Boiling point: 155.65 °C

Flash point: 44 °C (C.C.)

Auto-ignition temperature: 420 °C

Decomposition temperature: No data available

Flammability: Flammable

Vapor pressure: 5.27 hPa (20℃)

Relative density: No data available

Density: 0.944 – 0.948 g/cm³ (20℃)

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Relative gas density: 3.4

Solubility: Organic solvents: Soluble in ethanol.
Water: 13 % (10℃): 0.81

Partition coefficient noctanol/water (log Pow)
Explosive limits (vol %): 1.1 – 8.1 vol %Viscosity, kinematic:: 2.3 mm²/s (25℃)

Particle characteristics: No data available

10. Stability and reactivity
Reactivity: Ring-opening when reacting with acid and oxidizing agent.

Chemical stability: Stable under normal conditions. Turns yellow after long-term
storage.

Possibility of hazardous
reactions: Stable under normal conditions of use.

Conditions to avoid: Light, heat.

Incompatible materials: Acids, oxidizing substances.

Hazardous decomposition
products: Carbon monoxide.

11. Toxicological information
Acute toxicity (oral)
Acute toxicity (dermal)
Acute toxicity (inhalation): Harmful if swallowed
rat LD50=1296mg/kg: Toxic in contact with skinrabbit LD50=947mg/kg: No classification (gas)Toxic if inhaled
No classification (dust, mist): rat LC50=2450ppm/4h

Acute toxicity (vapor) Description
Acute toxicity (mist) Description
Skin corrosion/irritation:

Serious eye damage/irritation:

Respiratory sensitization:: rat LC50=3.21mg/L/4h
Causes skin irritation
Although there is a report that in a rabbit test with 2 samples ofcyclohexanone, rabbits exhibited necrosis after occlusive
application of one sample, then the sample was classified as
corrosive, in an evaluation for corrosiveness in rabbits, nocorrosion occurred in any rabbit. Application of the undiluted
substance with open contact was non-irritating to rabbit skin.
Additionally, although application of a 99% solution for 24-hour
under occlusive conditions caused strong skin irritation, theeffects slowly resolved and disappeared during a seven day period
after application. Based on these evidences of non-corrosive, thesubstance was classified into category 2.
Causes serious eye irritation
The undiluted substance placed in the eyes of rabbits produced
marked irritation and corneal injury. When the undiluted substance
was applied to rabbit eyes, corneal injury with mild iritis andconjunctivitis was reversible, but the eyes still showed mild
corneal damage at 14 days. Based on these data, the substance wasclassified into category 2A.
Classification not possible

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Skin sensitization:

May cause an allergic skin reaction
Since the substance is on the Frosch contact allergen list, thesubstance was classified into category 1.

Germ cell mutagenicity:

Carcinogenicity:

Reproductive toxicity:

STOT-single exposure:

STOT-repeated exposure:

Suspected of causing genetic defects
Based on a positive result in a rat bone marrow chromosomal
aberration test by subcutaneous injection (in vivo somatic cellmutagenicity test), the substance was classified into category 2.
No classification
IARC classifies it as group 3(not classifiable as to its
carcinogenicity to humans).
Suspected of damaging fertility or the unborn childIn a two-generation reproduction test in rats by inhalation
exposure, toxic symptoms such as lacrimation, irregular breathing
and ataxia was observed in the high dose group. In this group,
there was a reduction in the number of offspring, which wasinterpreted by the authors as a decrease in male fertility, andreduced survival of the offspring. Based on the data, the substancewas classified into category 2.
Causes damage to organs (respiratory organs)
May cause damage to organs (central nervous system)
May cause drowsiness or dizziness
Following oral administration of the substance to rats and mice,
hypnotic signs appeared. As a symptom following inhalation exposure
to guinea pigs and oral administration to rabbits, anesthesia isreported. Based on the data, the substance was classified into
category 3 (narcosis). Since there are reports that a highconcentration exposure resulted in deaths and that symptoms notedat acute toxic doses were CNS depression, the substance wasclassified into category 2 (central nervous system). Based on thefindings of hemorrhage of lungs in rat by oral administration of475 - 3800 mg/kg and lesions such as congestion and edema of thelungs, focal to diffuse hemorrhage of the lung parenchyma, thesubstance was classified into category 1 (respiratory organs).
Causes damage to organs (central nervous system, bone) throughprolonged or repeated exposure
Neurotoxic effects were examined in a group of 75 workers from afurniture factory who were exposed while coating wood withcyclohexanone. The exposures were observed to cause an increase in
the percentage of reported neurotoxic symptoms (mood disorders,memory difficulties, sleep disturbances, etc.). There is a reportthat the substance depresses the central nervous system. Based onthese data, the substance was classified into category 1 (central
nervous system). In the above mentioned examination, an increase in
the percentage of reported rheumatic symptoms was observed. Out ofthese symptoms, bone pain was reported on another document.
Therefore, the substance was classified into category 1 (bone).

Aspiration hazard:

Classification not possible

12. Ecological information
Ecotoxicity
Aquatic acute
Aquatic chronic: No classification
Pimephales promelas LC50=527mg/L/96h: No classification

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Persistence and degradability
Readily biodegradable
BOD : 87%
Bioaccumulative potential
Low bioconcentaration
BCF : 2.4
Mobility in soilHigh mobility
Koc : 15
Hazardous to the ozone layer
Ozone: Classification not possible

13. Disposal considerations
Ecological waste information: Burn in a chemical incinerator equipped with an afterburnerand a scrubber. Or entrust approved waste disposal companies
with the disposal.

Contaminated container andpackaging: In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea(IMDG)
UN-No. (IMDG)
Proper Shipping Name (IMDG)
Packing group (IMDG)
Transport hazard class(es)(IMDG)Air transport(IATA)
UN-No. (IATA)
Proper Shipping Name (IATA)
Packing group (IATA)
Transport hazard class(es)(IATA)

:
:
:
:

1915
CYCLOHEXANONE
III
3

:
:
:
:

1915
Cyclohexanone
III
3

Marine pollutant: Not applicable
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Pollutant category:Z
MFAG-No:127

15. Regulatory information
Regulatory information with regard to this substance in your country or region should be examined byyour own responsibility.

16. Other information
Data sources: Solvents Handbook, T, Asahara el, Kodansha Scientific Ltd.
（1976）.
Handbook of Dangerous Substances Springer-Verlag Tokyo（1991）.
Handbook of 17322 Chemical Products, The Chemical Daily Co.
（2022）.

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NITE Chemical Risk Information Platform (NITE-CHRIP), National
Institute of Technology and Evaluation.
The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully.The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements.The information herein is only provision of information, andit does not represent a guarantee the properties of the product.The Safety Data Sheet(SDS) is
prepared based on JIS Z7253.