●1999年以前の業績集
原著（英文）
1. Sei Sasaki, Fumiaki Marumo. Mechanisms of inhibition of proximal acidiﬁcation by PTH. Am. J. Physiol. 260:F833‒F838,
1991.
2. Michio Kuwahara, Sei Sasaki, Fumiaki Marumo. Mineralocorticoids and acidosis regulate H/HCO3 transport ofintercalated cells. J. Clin. Invest. 89:1388‒1394, 1992.
3. Kiyohide Fushimi, Shinichi Uchida, Yukichi Hara, Yukio Hirata, Fumiaki Marumo, Sei Sasaki. Cloning and expression ofapical membrane water channel of rat kidney collecting tubule. Nature 361:549‒552, 1993.
4. Shinichi Uchida, Sei Sasaki, Tetsushi Furukawa, Masayasu Hiraoka, Taihei Imai, Yukio Hirata, Fumiaki Marumo. Molecularcloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. J. Biol.
Chem. 268:3821‒3824, 1993.
5. Sei Sasaki, Kiyohide Fushimi, Hideuki Saito, Fumiko Saito, Shinichi Uchida, Kenichi Ishibashi, Michio Kuwahara, Tatsuro
Ikeuchi, Ken‒ichi Inui, Kiichiro Nakajima, Takushi X. Watanabe, Fumiaki Marumo. Cloning, characterization, and chromosomal
mapping of human collecting duct aquaporin‒CD. J. Clin. Invest. 93:1250‒1256, 1994.
6. Masanobu Kawasaki, Shinichi Uchida, Toshiaki Monkawa, Atsushi Miyawaki, Katsuhiko Mikoshiba, Fumiaki Marumo, Sei
Sasaki. Cloning and expression of a protein kinase C‒regulated chloride channel abundantly expressed in rat brain neuronalcells. Neuron 12:597‒604, 1994.
7. Kenichi Ishibashi, Sei Sasaki, Kiyohide Fushimi, Shinichi Uchida, Michio Kuwahara, Hideyuki Saito, Tetsushi Furukawa,Kiichiro Nakajima, Yumi Yamaguchi, Takashi Gojobori, Fumiaki Marumo. Molecular cloning and expression of a member of
the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane ofkidney collecting duct cells. Proc. Natl. Acad. Sci. USA 91:6269‒6273, 1994.
8. Susumu Adachi, Shinichi Uchida, Hiroshi Ito, Mimi Hata, Michiaki Hiroe, Fumiaki Marumo, Sei Sasaki. Two isoforms of achloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney. J. Biol.
Chem. 269:17677‒17683, 1994.
9. Shinichi Uchida, Sei Sasaki, Kiyohide Fushimi, Fumiaki Marumo. The isolation of human Aquaporin‒CD gene. J. Biol. Chem.
269:23451‒23455, 1994.
10. Matsuhiko Hayashi, Sei Sasaki, Hirohiko Tsuganezawa, Toshiaki Monkawa, Waichi Kitajima, Kohnosuke Konishi, KiyohideFushimi, Fumiaki Marumo, Takao Saryta. Expression and distribution of aquaporin of collecting duct are regulated byvasopressin V2 receptor in rat kidney. J. Clin. Invest. 94:1778‒1783, 1994.
11. Yoshio Terada, Kimio Tomita, M.K. Homma, Hiroshi Nonoguchi, T. Yang, T. Yamada, Sei Sasaki, Y. Yuasa, E.G. Krebs, F.
Marumo. Sequential activation of raf‒1 kinase, MAP kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renalcell. J. Biol. Chem. 269:31296‒31301, 1994.
12. Shinichi Uchida, Sei Sasaki, Kosaku Nitta, Keiko Uchida, Shigeru Horita, Hiroshi Nihei, Fumiaki Marumo. ClC‒K1 chloride
channel mediates transepithelial chloride transport in the rat thin ascending limb of Henle's loop. J. Clin. Invest. 95:104‒113,
1995.
13. Michio Kuwahara, Kiyohide Fushimi, Yoshio Terada, Liqun Bai, Fumiaki Marumo, Sei Sasaki. cAMP‒dependent
phosphorylation stimulates water permeability of AQP‒CD water channel protein expressed in xenopus oocytes. J. Biol.
Chem. 270:10384‒10387, 1995.
14. Naohiko Inase, Kiyohide Fushimi, Kenichi Ishibashi, Shinichi Uchida, Masahiko Ichioka, Sei Sasaki, Fumiaki Marumo.
Isolation of human aquaporin 3 gene. J. Biol. Chem. 270:17913‒17916, 1995.
15. Kazuo Kanno, Sei Sasaki, Yukio Hirata, San‒e Ishikawa, Kiyohide Fushimi, Setsuko Nakanishi, Daniel G. Bichet, Fumiaki

Marumo. Urinary excretion of aquaporin‒2 in patients with diabetes insipidus. New Engl. J. Med. 332:1540‒1545, 1995.
16. Liqun Bai, Kiyohide Fushimi, Sei Sasaki, Fumiaki Marumo. Structure of aquaporin‒2 vasopressin water channel. J. Biol.
Chem. 271:5171‒5176, 1996.
17. Hiroyuki Tamura, Laurent Schild, Nobuyuki Enomoto, Noriaki Matsui, Bernard C. Rossier, Sei Sasaki. Liddle diseasecaused by a missense mutation of b‒subunit of the epithelial sodium channel gene. J. Clin. Invest. 97:1780‒1784, 1996.
18. Hisato Sakamoto, Masanobu Kawasaki, Shinichi Uchida, Sei Sasaki, Fumiaki Marumo. Identiﬁcation of a new outwardly
rectifying Cl channel that belongs to a subfamily of the ClC Cl channels. J. Biol. Chem. 271:10210‒10216, 1996.
19. Kiyohide Fushimi, Sei Sasaki, Fumiaki Marumo. Phosphorylation of serine 256 is required for camp‒dependent
regulatory exocytosis of the aquaporin‒2 water channel. J. Biol. Chem. 272:14800‒14804, 1997.
20. Michio Kuwahara, Yong Gu, Kenichi Ishibashi, Fumiaki Marumo, Sei Sasaki. Mercury‒sensitive residues and pore site in
AQP3 water channel. Biochemistry 36:13973‒13978, 1997.
21. Kenichi Ishibashi, Michio Kuwahara, Yong Gu, Yukio Kageyama, Akira Tohsaka, Fumiaki Marumo, Sei Sasaki. Cloning andfunctional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol and urea. J.
Biol. Chem. 272:20782‒20786, 1997.
22. Sei Sasaki, Shinichi Uchida, Michio Kuwahara, Kiyohide Fushimi, Fumiaki Marumo. Aquaporins and ion conductance.
Science 275:1490‒1491, 1997.
23. Katsumi Goji, Michio Kuwahara, Yong Gu, Masafumi Matsuo, Fumiaki Marumo, Sei Sasaki. Novel mutations in aquaporin‒
2 gene in female siblings with nephrogenic diabetes insipidus: Evidence of disrupted water channel function. J. Clin. Endocr.
Metab. 83: 3205‒3209, 1998.
24. Yoshihiro Matsumura, SHinichi Uchida, Yoshiaki Kondo, Hiroaki Miyazaki, Shigeru Ko, Atsushi Hayama, Tetuji Morimoto,Wen Liu, Mikio Arisawa, Sei Sasaki, Fumiaki Marumo. Overt nephrogenic diabetes insipidus in mice lacking the CLC‒K1chloride channel. Nature Genet. 21: 95‒98, 1999.
25. Momono Yoshikawa, Shinichi Uchida, Atsushi Yamauchi, Akiko Miyai, Yujiro Tanaka, Sei Sasaki, Fumiaki Marumo.
Lacalization of CLC‒K2 chloride channel mRNA in the kidney. Am. J. Physiol. 276:F552‒F558, 1999.
26. Osamu Nakashima, Yoshio Terada, Seiji Inashita, Michio Kuwahara, Sei Sasaki, Fumiaki Marumo. Inducible nitric oxide
synthase can be induced in the absence of active nuclear factor‒kB in rat measangial cells. J. Am. Soc. Nephrol. 10:721‒
729, 1999.
27. Kazushi Yamauchi, Kiyohide Fushimi, Yumi Yamashita, Itsuki Shinbo, Sei Sasaki, Fumiaki Marumo. The expression andfunction of four AQP2 mutants in LLC‒PK1 cells. Kidney Int. 56:164‒171, 1999
28.Yoshio Terada, Seiji Inoshita, Osamu Nakashima, Mimi Tamamori, Hiroshi Ito, Michio Kuwahara, Sei Sasaki, FumiakiMarumo. Cell cycle inhibitors (p27Kip1 and p21CIP1) cause hypertrophy in LLC‒PK1 cells. Kidney Int. 56:494‒501, 1999
29.Itsuki Shinbo, Kiyohide Fushimi, Michihiro Kasahara, Kazushi Yamauchi, Sei Sasaki, Fumiaki Marumo. Functional analysis
of aquaporin‒2 mutants associated nephrogenic diabetes insipidus by yeast expression. Am. J. Physiol. 277:F734‒F741,1999.
30.Takako Saito, San‒e Ishikawa, Sei Sasaki, Minori Higashiyama, Shoichiro Nagasaka, Nobuya Fujita, Kiyohide Fujita, FumiakiMarumo, Toshikazu Saito. Lack of vasopressin‒independent upregulation of AQP‒2 gene expression in homozygous
Brattleboro rats. Am. J. Physiol. 277:R427‒R433, 1999.
31.Yoshio Terada, Osamu Nakashima, Seiji Inoshita, Michio Kuwahara, Sei Sasaki, Fumiaki Marumo. TGF‒b‒acting kinase‒1inhibits cell cycle and expression of cyclin D1 and A in LLC‒PK1 cells. Kidney Int. 56:1378‒1390, 1999
32.Masanobu Kawasaki, Toshiko Fukuma, Kazushi Yamauchi, Hisato Sakamoto, Fumiaki Marumo, Sei Sasaki. Identiﬁcation ofan acid‒activated Cl channel from human skeletal muscles. Am. J. Physiol. 277:C948‒C954, 1999.

33.Seiji Inoshita, Yoshio Terada, Osamu Nakashima, Michio Kuwahara, Sei Sasaki, Fumiaki Marumo. Roles of E2F1 inmesangial cell proliferation in vitro. Kidney Int. 56:2085‒2095, 1999
34.Hisato Sakamoto, Yoshikazu Sado, Ichiro Naito, Tae‒Hwan Kwon, Shinichi Inoue, Kenichi Endo, Masanobu Kawasaki,Shinichi Uchida, Soren Nielsen, Sei Sasaki, Fumiaki Marumo. Celluar and subcellular immunolocalization of ClC‒5 channel inmouse kidney: colocalization with H‒ATPase. Am. J. Physiol. 277:F957‒F965, 1999.
35. Michio Kuwahara, Itsuki Shinbo, Kazunori Sato, Yoshio Terada, Fumiaki Marumo, Sei Sasaki. Transmembrane Helix 5 iscritical for the high water permeability of aquaporin. Biochemistry 38:16340‒16346, 1999.
総説、著書、Proceedings（英文）1. Sei Sasaki, Fumiaki Marumo. Regulation of intracellular potassium in the rabbit proximal straight tubule cells. In The
Frontiers of Nephrology ed. by R.W. Berliner. pp47‒54, Elsevier Science Publishers. 1990.
2. Michio Kuwahara, Sei Sasaki, Fumiaki Marumo. Cell pH regulation in collecting tubules. In Nephrology ed. by M. Hatano.
pp1429‒1437, Springer‒Verlag. 1991.
3. Sei Sasaki. Proximal renal tubular acidosis (RTA): Normal proximal tubule function and evidence for cellular defects. InNephrology ed. by M. Hatano. pp1164‒1171, Springer‒Verlag. 1991.
4. Peter Agre, Sei Sasaki, Maarten J. Chrispeels. Aquaporins: a family of water channel proteins. Am. J. Physiol. 265: F461,1993.
5. Sei Sasaki, Kiyohide Fushimi, Shinichi Uchida, Fumiaki Marumo. Cloning and expression of two renal transport proteins
which are involved in urinary concentrating mechanisms: collecting duct water channel and thin ascending limb chloridechannel. In Vasopressin ed. by P. Gross, D. Richter, G.L. Robertson. pp325‒335, John Libbey Eurotext. 1993.
6. Sei Sasaki, Fumiaki Marumo. Cloning of kidney membrane transport proteins and its clinical implications. Clin. Sci.
87:122‒123, 1994.
7. Sei Sasaki, Kiyohide Fushimi, Fumiaki Marumo. The apical membrane water channel of collecting ducts (AQP‒CD). Exp.
Nephrol. 2:269‒272, 1994.
8. Sei Sasaki, Shinichi Uchida, Masanobu Kawasaki, Susumu Adachi, Fumiaki Marumo. ClC family in the kidney. Jpn. J.
Physiol. 44:S3‒S8, 1994.
9. Shinichi Uchida, Sei Sasaki, Fumiaki Marumo. Chloride transport across kidney epithelia through ClC chloride channels.
Jpn. J. Nephrol. 38:285‒289, 1994.
10. Sei Sasaki, Kiyohide Fushimi, Kenichi Ishibashi, Fumiaki Marumo. Water channels in the kidney collecting duct. KidneyInt.48:1082‒1087, 1995.
11. Kenichi Ishibashi, Sei Sasaki. Aquaporin water channels in mammals. Clin. Exp. Nephrol. 1:247‒253, 1997.
12. Sei Sasaki, Kenichi Ishibashi, Fumiaki Marumo. Aquaporin‒2 and ‒3: Representatives of the two subgroups of theaquaporin colocalized in the kidney collecting duct. Annu. Rev. Physiol. 60:199‒220, 1998.
13. Kenichi Ishibashi, Sei Sasaki. The dichotomy of MIP family suggests two separate origins of water channels. NewsPhysiol. Sci. 13:137‒142, 1998.
14. Tadashi Yamamoto, Sei Sasaki. Aquaporins in the kidney: emerging new aspects. Kidney Int. 54: 1041‒1051, 1998.
15. Sei Sasaki. Aquaporins in the kidney. Korean. J. Pharmacol. 2:271‒277, 1998.
16. San‒e Ishikawa, Sei Sasaki, Takako Saito, Toshikazu Saito. Urinary excretion of aquaporin‒2 in disorders of watermetabolism. Nephrol. Dial. Transpl. 13:1615‒1616, 1998.
17. Yoshio Terada, Seiji Inoshita, Osamu Nakashima, Michio Kuwahara, Sei Sasaki, Fumiaki Marumo. Cyclin and cyclin‒kinasesystem‒their potential roles in nephrology. . Nephrol. Dial. Transplant. 13:1913‒1916, 1998.
18. San‒e Ishikawa, Takako Saito, Sei Sasaki, Toshikazu Saito. Prompt and sustained regulation of aquaporin‒2 by arginine
vasopressin in collecting duct cells and clinical implication of urinary excretion of aquaporin‒2. Adv. Exp. Med. Biol.
449:407‒414, 1998.
19. Yoshio Terada, Osamu Nakashima, Seiji Inoshita, Michio Kuwahara, Sei Sasaki, Fumiaki Marumo. Mitogen‒activatedprotein kinase cascade and transcription factors: the opposite role of MKK3/6‒p38K and MKK1‒MAPK. Nephrol. Dial.
Transplant. 14: 45‒47, 1999.
20. Sei Sasaki. Molecular basis of organic anion and cation transport. Kidney Int. 57:1772‒1773, 2000
21. Kenichi Ishibashi, Michio Kuwahara, Sei Sasaki. Molecular biology of aquaporins. Rev Physiol Biochem Pharmacol. 141:1‒
32, 2000.