↢๮⑼ቇ✚ว⎇ⓥᡰេ࠮ࡦ࠲࡯ ህ᳇ᕈ⩶⎇ⓥಽ㊁1㧚⎇ⓥߩ᭎ⷐ
 ᒰಽ㊁ߢߪ⥃ᐥᓸ↢‛ቇߩ┙႐߆ࠄህ᳇ᕈ⩶࡮ህ᳇ᕈ⩶ᗵᨴ∝ߦ㑐ߔࠆၮ␆⊛࡮⥃ᐥ⊛⎇ⓥࠍ
ㅴ߼ߡ޿ࠆ‫ౕޕ‬૕⊛ߦߪ⎕்㘑ࠟࠬუ∓ࡏ࠷࡝࠿ࠬ∝ߥߤᲥ⚛↥↢ᕈߩህ᳇ᕈ⩶ߦࠃࠆᄖ࿃ᕈߩ
ᗵᨴ∝߅߽ߦⴚᓟߦ⷗ࠄࠇࠆህ᳇ᕈ⩶ߣㅢᕈ⩶߇⋧ਸ਼⊛ߦ∛ේᕈࠍ⊒ើߔࠆౝ࿃ᕈߩⶄᢙ⩶ᗵᨴ∝⧘⢩ࠍ߽ߟህ᳇ᕈ⩶ߦࠃࠆ㒮ౝᗵᨴ∝ߥߤߩህ᳇ᕈ⩶߇㑐ଥߔࠆᄙ⒳ᄙ᭽ߩᗵᨴ∝ߩ⸻ᢿᴦ
≮ߘߒߡ੍㒐ߦᓎߛߟࠃ߁ߥ⎇ⓥࠍ⚦⩶ቇ⊛ߥ┙႐߆ࠄⴕߞߡ޿ࠆ‫ޕ‬ህ᳇ᕈ⩶ߩಽ㔌ၭ㙃หቯᴺߩ
ᡷ⦟ህ᳇ᕈ⩶ߩ∛ේ࿃ሶህ᳇ᕈ⩶ߩ᛫⩶⮎ᗵฃᕈߩ᷹ቯߣߘߩ᷹ቯᴺߩᡷ⦟᛫ህ᳇ᕈ⩶૞↪
ࠍ᦭ߔࠆ‛⾰ߩត⚝ߣߘࠇࠄߩ᛫⩶ജߩ⹏ଔህ᳇ᕈ⩶ߩ᛫⩶⮎ߦኻߔࠆ⠴ᕈ⃻⽎ߩ⸃᣿ߘߒߡ
ህ᳇ᕈ⩶߇ఝ൓ߥࡅ࠻࿕᦭⚦⩶ฌߩ⇣Ᏹൻ߇ේ࿃ߣߥߞߡ߅ߎࠆ⒳‫ ޟߩޘ‬਎♿∛‫⎇ߩߡ޿ߟߦޠ‬ⓥ
ߥߤࠍዷ㐿ߒߡ޿ࠆ‫ޕ‬2㧚ฬ★

ᢎ᝼㧦ᷰㆺ㇌෹
ಎᢎ᝼㧦
↰ਛ㚅߅㉿
ഥᢎ㧦
ᓟ⮮㓉ᰴ
⎇ⓥ⵬ഥຬ㧦 ਛᎹᦶሶKunitomo Watanabe
Kaori Tanaka
Takatsugu Goto
Akiko Nakagawa

3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕1㧕ᷰㆺ㇌෹(ಽᜂ), ᧻ᧄື຦⋙ୃ. ህ᳇ᕈ⩶ᗵᨴ∝㧦࿑⺑⥃ᐥ⋴⼔ቇකቇ ࠺ࠫ࠲࡞  8 ᗵᨴ∝, ᧲੩㧦ᩣᑼળ␠ࠛ࠺ࠖ࠲࡯ࠪ࠶ࡊ㧧2010 ᐕ2㧕 ↰ਛ㚅߅㉿, ᷰㆺ㇌෹(ಽᜂ), ৻ጊᥓ, ጊญᕺਃ ⋙ୃ, 㘵ᴧ↱༹, ⥪↰৻ඳ ✬. ⠴ᕈህ᳇ᕈ⩶㧦Bacteroides, C.difficile㧧ᗵᨴ∝⸻≮ߩၮ␆ߣ⥃ᐥ—⠴ᕈ⩶ߩ೙ᓮߦะߌߡ࡯ ᄢ㒋࡮᧲੩㧦ක⮎ࠫࡖ࡯࠽࡞␠;2010 ᐕ㧦64г70㧚✚⺑

1㧕 ᷰㆺ㇌෹, ᓟ⮮㓉ᰴ, ↰ਛ㚅߅㉿. ࠣ࡜ࡓ㓁ᕈህ᳇ᕈ⃿⩶⟲. ࡕ࠳ࡦࡔ࠺ࠖࠕ 2010
ᐕ㧧56(12)㧦320-328ේ⪺1㧕ᄢ㐷ᐽᔒ, ↰ਛ㚅߅㉿, ᷰㆺ㇌෹. ህ᳇ᕈࠣ࡜ࡓ㒶ᕈ᪝⩶ߣߒߡ⷗ㅏߐࠇ߿ߔ޿ࡈ࠶࠻ࡏ࡯࡞ဳClostridium ߩหቯߦ㑐ߔࠆᬌ⸛, ᣣᧄ⥃ᐥᓸ↢‛ቇ㔀⹹ 2010 ᐕ㧧20 Ꮞ㧔1 ภ㧕㧦9-19.
2㧕ᴡరብผ, ㊁᧛િᒾ, ḩጊ㗅৻, ጊጟ৻ᷡ, ᵻ㊁⵨ሶ, Ỉ᧛ᴦ᮸, ᧃ᧻ኡਯ, ኹ࿾⌀ᑿ, ᯅᷰᒾౖ,᧻Ꮉᵗሶ, ᧻ේ⨃ⷙ, ችㇱ㜞ౖ, ਃ㡞ᑝ❥, ᷰㆺ㇌෹. ⴊᶧ᧚ᢱࠃࠅಽ㔌ߐࠇߚ⢖Ἳ⃿⩶ߦኻߔࠆฦ⒳᛫⩶⮎ߩ᛫⩶ᵴᕈ෸߮ࡕࡦ࠹ࠞ࡞ࡠࠪࡒࡘ࡟࡯࡚ࠪࡦࠍ↪޿ߚ࡟ࠬࡇ࡜࠻࡝࡯ࠠࡁࡠࡦ⮎ߩ᦭ലᕈ⹏ଔ, The Japanese Journal of Antibiotics 2010 ᐕ㧧63 Ꮞ(1 ภ)㧦1-10.
3㧕㒙ਭỈ๺ᒾ, ጊ↰ℂᕺ, ᨐ 㐳ᥙ, ቯ਽⑲⾆, ᧻ේ੩ሶ, ࿯↰⵨ਃ, ᷰㆺ㇌෹, ੑࡁች⌀ਯ, ➚➓቞, ᧛ጊᰴ຦. ࠢࡑࠩࠨ฽᦭ᚑಽߦࠃࠆࡅ࠻ࠨࠗ࠻ࡔࠟࡠ࠙ࠗ࡞ࠬߩჇᱺᛥ೙ലᨐ, ᣣᧄ⵬ቢઍᦧක≮ቇળ㔀⹹ 2010 ᐕ㧧7 Ꮞ(1 ภ)㧦171-177.
4㧕ᧁ᧛࿖↵, ጊጯ↱૫, ኹ↰㆏ᓼ, ᄢᧁᕺ⟤ሶ, ↰ਛ㚅߅㉿, ᷰㆺ㇌෹, ਃ㡞ᑝ❥. Bifidobacterium߅ࠃ߮ Clostridium difficile ߦኻߔࠆ⚻ญࠠࡁࡠࡦ♽⮎ߩ᛫⩶ᵴᕈ, The Japanese Journal ofAntibiotics 2010 ᐕ㧧63 Ꮞ(2 ภ):171-177.
5㧕ጊጯ↱૫, ↰ਛ㚅߅㉿, ⮮Ꮞᗲ, ᫪⒤㜞, ᧁਅિ๋, ᷰㄝຬᡰ, ⧯ᮎ᣿ᒾ, ᷰㆺ㇌෹, ਃ㡞ᑝ❥. ෆᎽ≸ᧃᦼߩ≸ᕈ⣻⤑Ἳߦว૬ߒߚ Clostridium sordellii ߦࠃࠆ߹ࠇߥ⩶ⴊ∝ߩ৻଀ႎ๔߅ࠃ߮
ᢥ₂⊛⠨ኤ, ᣣᧄᄖ⑼ᗵᨴ∝ቇ㔀⹹ 2010 ᐕ㧧7 Ꮞ(2 ภ)㧦155-160.
6㧕᧻Ꮉᵗሶ, ጊጯ↱૫, ਃ㡞ᑝ❥, Ỉ᧛ᴦ᮸, ᧻ේ⨃ⷙ, ጊጟ৻ᷡ, ᵻ㊁⵨ሶ, ⍹ㇹầ⟤, ᧃ᧻ኡਯ,ᱞ⮮ᢅᒄ, ኹ࿾⌀ᑿ, ᯅᷰᒾౖ, ኹ↰ᶈผ, ૒ષᶈ๺, ችㇱ㜞ౖ, ↰ਛ㚅߅㉿, ᷰㆺ㇌෹, ⑺↰⨃᮸,ጟ↰㓷ሶ, ┻ᧄ㕏ᒾ, ૒ਭ㑆ቁ. ጘ㒂⋵ਅߦ߅ߌࠆ⢖Ἳ⃿⩶ߩ∉ቇ⸃ᨆ, The Japanese Journal of ̆1̆Antibiotics 2010 ᐕ㧧63 Ꮞ(3 ภ)㧦224-241.
7 㧕Ichiishi S, Tanaka K, Nakao K, Izumi K, Mikamo H, Watanabe K. First isolation of
Desulfovibrio from human vaginal flora. Anaerobe 2010;16:229-233.
8 㧕 Ninomiya M, Tanaka K, Tsuchida Y, Muto Y, Koketsu M, Watanabe K. Increased
bioavailability of tricin – Amino acid derivatives via a prodrug approach. Journal of MedicinalChemistry 2011; 54:1529-1536.

ቇળ‫ޣ‬࿖㓙ቇળ‫ޤ‬1) Yamagishi Y, Tanaka K, Watanabe K, Mikamo H. Bacteremia caused by Clostridium
sordellii : a case report and a review of the litereture. 10th Biennial Congress of theAnaerobe Society of the Americas. Philadelphia, USA, 2010.7.7-10.
‫ޣ‬࿖ౝቇળ࡮⎇ⓥળ৻⥸Ṷ㗴‫ޤ‬1) Ꮢ⍹ථ‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬ਃ㡞ᑝ❥‫ޔ‬ᷰㆺ㇌෹㧦↥ᇚੱ⑼㗔ၞߦ߅ߌࠆၭ㙃ᴺ෸߮ಽሶ↢‛ቇ⊛ᚻᴺߦࠃࠆ⎫㉄ㆶర⚦⩶ߩᬌ⚝‫ ╙ޔ‬84 ࿁ᣣᧄᗵᨴ∝ቇળ✚ળ‫ޔ‬੩ㇺ‫ޔ‬2010.4.5-62) ᓟ⮮㓉ᰴ‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬Tran Minh Chau‫ޔ‬ᷰㆺ㇌෹㧦Bacteroides fragilis ↱᧪䈱䉦䊦䊋䊕䊈䊛㜞ᐲ⠴ᕈવ㆐ᕈ䊒䊤䉴䊚䊄䈱ోႮၮ㈩೉᳿ቯ䈭䉌䈶䈮⩶ᩣ㑆䈪䈱ಽᏓ⸃ᨆ‫ ╙ޔ‬47 ࿁࿁ᣣᧄ⚦⩶ቇળਛㇱᡰㇱ✚ળ‫ޔ‬ᣂẟ‫ޔ‬2009.9.5.
3) ↰ਛ㚅߅㉿‫ޔ‬ખየ⾫৻‫ޔ‬Tran Minh Chau‫ޔ‬ᓟ⮮㓉ᰴ‫ޔ‬ਃ㡞ᑝ❥‫ޔ‬ᷰㆺ㇌෹㧦ኙᄤᐔ᧼Ꮧ㉼ᴺߦࠃࠅᬌ⸛ߒߚ Desulfovibrio ߩ⮎೷ᗵฃᕈ‫ ╙ޔ‬58 ࿁ᣣᧄൻቇ≮ᴺቇળ⷏ᣣᧄᡰㇱ✚ળ‫ޔ‬ᄢಽ‫ޔ‬2010.11.25-26.
4㧕ᚭญ┨ᒄ‫ޔ‬ᄢᬮᷡᢥ‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬ᄢႦ༑ੱ‫ޔ‬ᩙේ⌀Ẵ‫ޔ‬ጊ↰ᥓ‫ޔ‬㜞ᧁℂᕺ‫ޔ‬ฎ᧛⛗㉿‫ޔ‬ዊᩙ⼾ሶ‫⚦ޔ‬Ꮉ⋥ੱ‫ޔ‬Ⓑⷺ㤗⴩‫ޔ‬ᳯፒቁⴕ㧦ⴊᶧၭ㙃ࠃࠅᕆᕈ೨㛽㜑ᕈ⊕ⴊ∛߆ࠄᬌ಴ߐࠇߚᣂ
⩶⒳ Leptotrichia sp.‫ ╙ޔ‬22 ࿁ᣣᧄ⥃ᐥᓸ↢‛ቇળ✚ળ‫ޔ‬ጟጊ‫ޔ‬2011.1.8-95㧕ዊᨋਁ㉿ሶ‫↰ޔ‬ਛผሶ‫⮮ޔ‬ේᥓሶ‫ޔ‬࿖ᐢ⺈ሶ‫ޔ‬ᳯᚑඳ‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬ᷰㆺ㇌෹㧦ህ᳇ᕈ⩶↪
ඨᵹേ⏕⹺ၭ࿾ߩ⹏ଔ-⥃ᐥಽ㔌ᩣߢߩᚑ❣-‫ ╙ޔ‬22 ࿁ᣣᧄ⥃ᐥᓸ↢‛ቇળ✚ળ‫ޔ‬ጟጊ‫ޔ‬
2011.1.8-96㧕ᳯᚑඳ‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬ᷰㆺ㇌෹㧦ህ᳇ᕈ⩶↪ඨᵹേ⏕⹺ၭ࿾ߩ⹏ଔ-଻ሽ⩶ᩣߢߩᚑ❣‫╙ޔ‬
22 ࿁ᣣᧄ⥃ᐥᓸ↢‛ቇળ✚ળ‫ޔ‬ጟጊ‫ޔ‬2011.1.8-97㧕ጊጯ↱૫‫ޔ‬Ỉ᧛ᴦ᮸‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬ᷰㆺ㇌෹‫ޔ‬ਃ㡞ᑝ❥㧦Desulfovibrio fairfieldensis ⩶ⴊ∝ߩ 1 ଀‫ ╙ޔ‬41 ࿁ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળ‫౓ޔ‬ᐶ‫ޔ‬2011.3.128㧕ᓟ⮮㓉ᰴ‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬Tran Minh Chau‫ޔ‬ᷰㆺ㇌෹㧦Bacteroides fragilis ↱᧪䈱䉦䊦䊋䊕䊈䊛⠴ᕈ䊒䊤䉴䊚䊄䈱ోႮၮ㈩೉᳿ቯ䈭䉌䈶䈮⩶ᩣ㑆䈪䈱ಽᏓ⸃ᨆ‫ ╙ޔ‬41 ࿁ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળ‫౓ޔ‬ᐶ‫ޔ‬2011.3.12‫ޣ‬࿖ౝቇળ࡮⎇ⓥળ᜗ᓙ⻠Ṷ‫ޤ‬1㧕 ᷰㆺ㇌෹㧦․೎⻠Ṷ‫ޟ‬ህ᳇ᕈ⩶ߩ⮎೷⠴ᕈߩ⃻⁁‫ ╙ޠ‬84 ࿁ᣣᧄᗵᨴ∝ቇળ✚ળ‫ޔ‬੩ㇺ‫ޔ‬2010.4.5-62㧕 ᷰㆺ㇌෹㧦ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬㜞㦂⠪∔ᖚߦะߌߚᣂߒ޿ഃ⮎ࠪ࡯࠭ߣߒߡߩࠢࡑࠩࠨ‫ ╙ޠ‬10࿁ᣣᧄ⥃ᐥਛක⮎ቇળ‫ޔ‬ንጊ‫ޔ‬2010.9.
3㧕 ↰ਛ㚅߅㉿㧦ᗵᨴ∝࡟ࡆࡘ࡯‫ޟ‬ህ᳇ᕈ⩶ᗵᨴ∝࡟ࡆࡘ࡯‫ ╙ޠ‬84 ࿁ᣣᧄᗵᨴ∝ቇળ✚ળ‫ޔ‬੩ㇺ‫ޔ‬2010.4.5-64㧕 ↰ਛ㚅߅㉿㧦ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬ᗵᨴ∝ߩ⸻ᢿߣᴦ≮ߘߒߡ੍㒐 Up-to-Date㧦ህ᳇ᕈ⩶ᗵᨴ∝‫ޔޠ‬ጘ㒂‫ޔ‬2010.6.26

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‫ޣ‬࿖ౝቇળᐳ㐳࡮มળ‫ޤ‬1㧕ᷰㆺ㇌෹㧦৻⥸Ṷ㗴‫ ╙ޔ‬41 ࿁ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળ‫౓ޔ‬ᐶ‫ޔ‬2011.3.12.

4㧚⎇ⓥ⾌₪ᓧ⁁ᴫᅑቇነ㒝㊄ฃ౉

5ઙ

ฃ⸤⎇ⓥ

2ઙ

5㧚ቇળᵴേ

1㧕ቇળᓎຬ
ᷰㆺ㇌෹㧦
1㧕ᣣᧄᗵᨴ∝ቇળ⹏⼏ຬ࡮ਛᣣᧄ࿾ᣇળℂ੐
2㧕⥃ᐥᓸ↢‛ㄦㅦ⸻ᢿ⎇ⓥળᐙ੐
3㧕ᣣᧄൻቇ≮ᴺቇળ⹏⼏ຬ
4㧕ᣣᧄ⥃ᐥ⣺ౝᓸ↢‛ቇળℂ੐
5㧕ᣣᧄ⚦⩶ቇળਛㇱᡰㇱ⹏⼏ຬ6㧕ᣣᧄ⥃ᐥᓸ↢‛ቇળ⹏⼏ຬ
7㧕ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળㆇ༡ᆔຬ
8㧕ᣣᧄ⥃ᐥᓸ↢‛ቇળህ᳇ᕈ⩶ᬌᩏࡑ࠾ࡘࠕ࡞૞ᬺᆔຬળᆔຬ(ᐔᚑ 21 ᐕ 8 ᦬ޯ⃻࿷)↰ਛ㚅߅㉿㧦1) ᣣᧄൻቇ≮ᴺቇળ⹏⼏ຬ
2㧕ᣣᧄ⥃ᐥᓸ↢‛ቇળ⹏⼏ຬ
3㧕ᣣᧄ⚦⩶ቇળਛㇱᡰㇱ⹏⼏ຬ
4㧕ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળㆇ༡ᆔຬ
5㧕ᣣᧄ⥃ᐥᓸ↢‛ቇળ ህ᳇ᕈ⩶ᬌᩏࡑ࠾ࡘࠕ࡞૞ᬺᆔຬળᆔຬ(ᐔᚑ 21 ᐕ 8 ᦬ޯ⃻࿷)

2㧕ቇⴚ㔀⹹
ᷰㆺ㇌෹㧦1㧕 ⥃ᐥᓸ↢‛ㄦㅦ⸻ᢿ⎇ⓥળ㔀⹹㧧✬㓸ᆔຬ(㨪ᐔᚑ 24 ᐕ 5 ᦬)
2㧕 Anaerobe (Elsevier): Editorial board(2010.03~)

6㧚␠ળᵴേ
‫ޝ‬ህ᳇ᕈ⩶ᬌᩏ࠮ࡒ࠽࡯‫ޞ‬੹ᣣߩᄢቇකቇㇱߦ߅ߌࠆᗵᨴ∝ቇߩ⻠⟵߇ౝ⑼ቇߩ⻠⟵ో૕ߦභ߼ࠆഀวߪ‫ޔ‬ᭂ߼ߡዋߥ޿ߎߣ߇ࠊ߆ߞߡ޿ࠆ‫ޔߚ߹ޕ‬ᗵᨴ∝ቇߩਛߢ߽‫ޔ‬ህ᳇ᕈ⚦⩶ቇߦ㑐ߔࠆ⻠⟵ߩභ߼ࠆഀวߪߐࠄߦᭂ߼ߡዋߥߊ‫ߩߘޔ‬ᢎ⢒ߩ߶ߣࠎߤߪ‫ޔ‬තᓟᢎ⢒ߦଐሽߒߥߌࠇ߫ߥࠄߥ޿⃻⁁ߢ޽ࠆ‫ޕ‬ᬌᩏᛛᏧߩᢎ⢒ߦ㑐ߒߡ߽ห᭽ߩߎߣ߇⸒߃ࠆ‫ޕ‬ህ᳇ᕈ⚦⩶ቇߣህ᳇ᕈ⩶ᗵᨴ∝ߩතᓟᢎ⢒ߦ߅ߌࠆᧄᣉ⸳ߩᓎഀߪ‫߇ࠊޔ‬࿖ߦ߅޿ߡᭂ߼ߡᄢ߈޿ߣ⠨߃ࠄࠇࠆ‫ޕ‬
ህ᳇ᕈ⩶ᗵᨴ∝ߪ‫ޔ‬ౝ⑼‫ޔ‬ᄖ⑼‫ޔ‬ᢛᒻᄖ⑼‫↥ޔ‬ᇚੱ⑼‫ޔ‬⡊㥦ຜ༄⑼‫ޔ‬ᱤ⑼ญ⣧ᄖ⑼ߥߤ᏷ᐢ޿㗔ၞߢ⷗ࠄࠇ‫ޔ‬ህ᳇ᕈ⩶ߩ⥃ᐥᬌᩏߪᗵᨴ∝ߩ⸻ᢿ࡮ᴦ≮ߦ㊀ⷐߢ޽ࠆ‫ޔߪ࡯࠽ࡒ࠮ᧄޕ‬ህ᳇ᕈ⩶߅ࠃ߮ህ᳇ᕈ⩶ᗵᨴ∝ߦ⥝๧ߩ޽ࠆᣇ‫ᦨޔߦޘ‬ᣂߩᖱႎࠍ੤߃ߚో⥸⊛ߥ⍮⼂ߣᬌᩏߦ㑐ࠊࠆᛛⴚ㧔ᬌ૕ណข‫ޔ‬ಽ㔌‫ޔ‬ၭ㙃‫ޔ‬หቯ‫ޔ‬ㆮવሶᬌᩏߥߤ㧕ࠍ⠌ᓧߒߡ㗂ߊߎߣࠍ⋡⊛ߣߒߡታᣉߒ ̆3̆ߡ޿ࠆ‫ޕ‬ౝኈ㧦ህ᳇ᕈ⩶ߩขᛒ߿⥃ᐥህ᳇ᕈ⩶ቇߦᔅⷐߥ⍮⼂ࠍቇ߱⻠⟵ߣ⥃ᐥ᧚ᢱ߆ࠄಽ㔌ߐࠇࠆਥⷐ
ߥህ᳇ᕈ⩶ߩᒻᘒ࡮ᕈ⁁ⷰኤࠍਥ૕ߣߒߚታ⠌‫ޕ‬ታ⠌ߪ 2 ੱ 1 ⚵ߢታᣉߒ‫ޔ‬ታ⠌ࠍㅢߒߡህ᳇ᕈ
⩶ߩಽ㔌࡮หቯ߹ߢࠍᛠី಴᧪ࠆࠃ߁ߦߥࠆߎߣࠍ⋡ᮡߦߒߡ޿ࠆ‫ޕ‬ߎࠇ߹ߢߩ㐿௅࿁ᢙ㧦40 ࿁ ✚ෳടੱᢙ㧦⚂ 1602 ฬ‫ޝ‬ህ᳇ᕈ⩶ߩ⩶ᩣ଻ሽ⁁ᴫߣ⩶ᩣߩಽਈ‫ޞ‬ 1㧕ህ᳇ᕈ⩶଻ሽ⩶ᩣߩ଻᦭⁁ᴫa) ህ᳇ᕈ⩶ෳ⠨⩶ᩣ⚂ 190 ᩣb) ฦ⒳ᗵᨴ∝‫∛ޔ‬ᘒ↱᧪ߩህ᳇ᕈ⩶⥃ᐥಽ㔌ᩣ
⚂ 6,800 ᩣᗵᨴ∝೎ౝ⸶㧦⢙㆏ᗵᨴ∝ ‫ޔ‬⣻⣧ౝᗵᨴ∝‫↥ޔ‬ᇚੱ⑼ᗵᨴ∝‫ޔ‬⡊㥦ຜ༄⑼ᗵᨴ∝‫ޔ‬ᢛᒻᄖ⑼ᗵᨴ∝‫ޔ‬ญ⣧ᄖ⑼㗔ၞᗵᨴ∝‫ޔ‬๭ๆེ⑼㗔ၞᗵᨴ∝ ↱᧪⩶ᩣ
 2㧕⩶ᩣߩಽਈ
ᣣᧄ⚦⩶ቇળᢎ⢒↪⩶ᩣߩಽਈ
⎇ⓥ↪⩶ᩣߩಽਈ
㐿⊒⎇ⓥ↪⩶ᩣߩಽਈ

3 ⩶⒳ 3 ᩣ
3 ⩶⒳ 12 ᩣ
1 ⩶⒳ 12 ᩣ

7. ᡰេ

࡮㒮ౝᗵᨴ⺞ᩏߦߣ߽ߥ߁ಽ㔌⩶ߩPFGE⸃ᨆ㧔ଐ㗬㧕㧦ቇౝ 2ઙ㧔24ᬌ૕㧕㧦ቇᄖ 1ઙ㧔2ᬌ૕㧕࡮㒮ౝᗵᨴ⺞ᩏߦߣ߽ߥ߁㥦⣧ᬌᩏ㧔ଐ㗬㧕㧦ቇౝ 1ઙ㧔36ᬌ૕㧕࡮⥃ᐥ᧚ᢱ߆ࠄಽ㔌ߐࠇߚህ᳇ᕈ⩶ߩᕈ⁁⹜㛎‫ޔ‬หቯ㧔ଐ㗬㧕㧦ቇౝ 1ઙ㧔1ᩣ㧕㧦ቇᄖ 8ઙ㧔13ᩣ㧕࡮ᄙ೷⠴ᕈህ᳇ᕈ⩶ߩ♖ᩏ㧔ଐ㗬㧕㧦ቇᄖ 2ઙ࡮ේ࿃ਇ᣿∔ᖚߦ߅ߌࠆ⩶ᬌ⚝(ଐ㗬)㧦ቇᄖ 1ઙ࡮วᚑ᦭ᯏൻว‛ߩ᛫⩶ജ᷹ቯ㧔ᣉ⸳೑↪߅ࠃ߮ᛛⴚᜰዉ㧕ቇౝ 1ઙ
࡮C.difficileߩหቯߣᲥ⚛↥↢ߦߟ޿ߡ㧔ᖱႎឭଏ㧕㧦ቇᄖ 1ઙ࡮੃ఽࡏ࠷࡝࠿ࠬ∝ߦߟ޿ߡ(ᖱႎឭଏ)㧦ቇౝ1ઙ‫ޔ‬ቇᄖ1ઙ
࡮ህ᳇ᕈ⩶ߩหቯߦߟ޿ߡ㧔ᛛⴚ⋧⺣㧕㧦ቇౝ 2ઙ
࡮ህ᳇ᕈ⩶ߩಽ㔌࡮ၭ㙃ߦߟ޿ߡ㧔ᛛⴚ⋧⺣㧕㧦ቇᄖ 2ઙ࡮⥃ᐥ᧚ᢱ߆ࠄಽ㔌࡮หቯߐࠇߚህ᳇ᕈ⩶⒳ߦߟ޿ߡ㧔ᖱႎឭଏ㧕㧦ቇᄖ 2ઙ࡮⥃ᐥ᧚ᢱ߆ࠄಽ㔌ߐࠇߚህ᳇ᕈ⩶ߩ⥃ᐥ⊛ᗧ⟵‫ޔ‬᛫⩶⮎ᗵฃᕈߦߟ޿ߡ㧔ᖱႎឭଏ㧕㧦ቇౝ 2ઙ

 

̆4̆

㧦ቇᄖ 4ઙ࡮ߘߩઁ㧔⋧⺣㧕㧦ቇᄖ 20ઙ8. ᣉ⸳⸳஻ ጘ㒂ᄢቇ↢๮⑼ቇ✚ว⎇ⓥᡰេ࠮ࡦ࠲࡯ህ᳇ᕈ⩶⎇ⓥಽ㊁ߪ‫ޔ‬කቇㇱ᫟㧣㓏ߦ૏⟎ߔࠆ‫଻⛔♽ޕ‬ሽߩㇱደࠍ஻߃ߡ޿ࠆ‫ޕ‬ህ᳇ᕈࠣࡠ࡯ࡉࡏ࠶ࠢࠬ‫ޔ‬ህ᳇ᕈࡢ࡯ࠢࠬ࠹࡯࡚ࠪࡦ㧔ฦ 1 บ㧕ࠟࠬ⟎឵ⵝ⟎(1 บ)߰ࠄࠎེ‫ޔ‬὇㉄ࠟࠬࠗࡦࠠࡘࡌ࡯࠲࡯ࠢ࡝࡯ࡦࡌࡦ࠴቟ోࠠࡖࡆࡀ࠶࠻⥄േ⚦⩶หቯ‫ޔ‬ᗵฃᕈ᷹ቯࠪࠬ࠹ࡓ
DNA ࠪ࡯ࠢࠛࡦࠨ࡯
ࠨ࡯ࡑ࡞ࠨࠗࠢ࡜࡯

9. ⥃ᐥህ᳇ᕈ⩶ቇߩዷᦸߦߟ޿ߡ ህ᳇ᕈ⩶ߩၭ㙃ᴺߩᡷ⦟ߦࠃࠅή⧘⢩ህ᳇ᕈ⩶ࠍ⎇ⓥߩኻ⽎ߣߔࠆ⎇ⓥ⠪ߪჇടߒߚ‫ޔ߫߃଀ޕ‬ᱤ๟∛∛ේ૕ߩ৻ߟߢ޽ࠆ Porphyromonas gingivalis ߩࠃ߁ߦ․ቯߩή⧘⢩ህ᳇ᕈ⩶ߩ⩶⒳ߦߟ޿ߡ‫ޔ‬∛ේ࿃ሶߩ⎇ⓥߥߤ߇‫ޔ‬ಽሶ↢‛ቇ⊛ߥ࡟ࡌ࡞ߢ߆ߥࠅᅏᷓߊⴕࠊࠇߡ޿ࠆ‫ⶄޔߒ߆ߒޕ‬ᢙ⩶ᗵᨴ∝ߢ޽ࠆή⧘⢩ህ᳇ᕈ⩶ߦࠃࠆᗵᨴ∝ߪ‫ޔ‬ᗵᨴᎽ߆ࠄߩή⧘⢩ህ᳇ᕈ⩶ߩ⩶⒳ࠍ୘‫⸃ߦޘ‬ᨆߔࠆߎߩࠃ
߁ߥಽሶ↢‛ቇ⊛ࠕࡊࡠ࡯࠴ߩઁߦ‫ޔ‬ᗵᨴᎽߩή⧘⢩ህ᳇ᕈ⩶ࠍᅢ᳇ᕈ⩶ߣߩ㑐ࠊࠅߩਛߢ✚ว⊛ߦ⸃ᨆߔࠆᔅⷐ߇޽ࠆ‫ߩࡎ࠶ࠦޕ‬ේೣߦว⥌ߒߥ޿ህ᳇ᕈ⩶ᗵᨴ∝ߩ⊒↢ᯏ᭴ߩ⸃᣿ߦߪ‫⥃ޔ‬ᐥߣㅪ៤ߒߚ⹦⚦ߥࠕࡊࡠ࡯࠴߇ᔅⷐߢ޽ࠆ‫ޕ‬ ߹ߚ‫ޔ‬㜞㦂ൻ␠ળߩ೔᧪ߦࠃࠆක≮ࠦࠬ࠻ߩ਄᣹ߦኻߔࠆ޿ࠈ޿ࠈߥኻ╷߇⻠ߓࠄࠇࠆࠃ߁ߣߒߡ޿ࠆ‫ޔߦ․ޕ‬ᣂߒߊណ↪ߐࠇࠆᣇะߦ޽ࠆක≮೙ᐲߩ዁᧪ߩᄌ㕟ߩᣇะᕈߦࠃߞߡߪ‫⑼ޔ‬ቇ⊛ߥᕁ⠨ߣࠕࡊࡠ࡯࠴߇ᔅⷐߢ‫ޔ‬කቇ⊛ߦㆡᱜߥᬌᩏ⸘↹߇ᔅⷐߣߥࠆ‫ޕ‬ᗵᨴ∝ߩ⸻ᢿᴦ≮ߦ㊀ⷐߥၭ㙃߿หቯ߇ᾘ㔀ߥህ᳇ᕈ⩶ߦ㑐ߔࠆᬌᩏࠍߤߩࠃ߁ߦⴕߞߡ޿ߊ߆ߪᄢ߈ߥ㑐ᔃ੐ߢ޽ࠆ‫ޕ‬ಽሶ↢‛ቇ⊛ᚻᴺߦࠃࠆㄦㅦൻߪ‫ޔ‬ಽ㔌ߒߚ⩶ߩหቯᴺߣߒߡߪᄢ޿ߦᦼᓙߐࠇࠆ߇‫ޔ‬ᣥ᧪߆ࠄߩ↢‛ቇ⊛ᚻᴺ߽シⷞߔࠆߎߣߪߢ߈ߥ޿‫ߩࠄࠇߎޕ‬ᣇᴺ⺰ࠍⲢวߐߖߚᗵᨴ∝ߦኻߔࠆᬌᩏᴺߩࠟࠗ࠼࡜ࠗࡦࠍᢛ஻ߒ
ߡ޿ߊߎߣߪ⾰ߩ㜞޿ක≮ࠍⴕ߁਄ߢᭂ߼ߡ㊀ⷐߢ޽ࠆ‫ޔߦ․ޕ‬ህ᳇ᕈ⩶ᗵᨴ∝ߩਛߢ߽૕ౝᷓㇱߦ⊒↢ߔࠆ∛ᄌߢ‫ޔ‬ᬌ૕ណข߇࿎㔍ߥᗵᨴ∝ߦ߅ߌࠆህ᳇ᕈ⩶ߩ㑐ਈࠍᣧᦼߦᱜ⏕ߦ⍮ࠆߦߪ‫ޔ‬ಽሶ↢‛ቇ⊛ᚻᴺએᄖߩᣂߒ޿ᚻᴺߩ㐿⊒߇ᔅⷐߢ޽ࠆ‫ޕ‬ ᖡᕈ⣲≌߿♧ዩ∛‫ߪߦࠄߐޔ‬⒖ᬀ߿ᓟᄤᕈ఺∉ਇో∝୥⟲ߥߤ఺∉ਇోኋਥ߇῜⊒⊛ߦჇടߒߟߟ޽ࠆ੹‫ߦ⤑☼ߩੱޔ‬ఝ൓ߦሽ࿷ߔࠆẜ࿷⊛∛ේᕈࠍ᦭ߔࠆᣣ๺⷗∛ේ૕ߢ޽ࠆή⧘⢩ህ᳇ᕈ⩶ߩ㊀ⷐᕈߪ߹ߔ߹ߔ㜞ߊߥࠆߢ޽ࠈ߁‫੹ޕ‬ᓟ‫⥃ޔ‬ᐥߣߩኒធߥ౒ห⎇ⓥ߇ߢ߈ࠆࠃ߁ߥᣂߒ޿⚵❱ߠߊࠅࠍᮨ⚝ߒߡⴕߊ੍ቯߢ޽ࠆ‫ޕ‬

ઃ⴫. ⥃ᐥ᧚ᢱ࡮ᱜᏱ⚦⩶ฌߦߺࠄࠇࠆਥߥህ᳇ᕈ⩶Phylum BXIII FirmicutesClass㧔✁㧕 I
ClostridiaOrder (⋡) I Clostridiales
Family(⑼) I. Clostridiaceae ̆5̆Genus Clostridium
C. perfringens
C. bifermentans
C. novyi
C. sordellii
C. butyricum
C. coccoides
C. sphenoides
C. oroticum
C. innocuum
C. ramosumC. scindens
C. hylemonae
C. hiranonis
C. sporogenes
C. clostridiiforme
C. paraputrificum
C. putrificum
C. septicum
C. difficile
Family III. Peptostreptococaceae
Genus Peptostreptococcus
P. anaerobius
P. stomatis
Genus Finegoldia
F. magna
Genus Parvimonas
P. micra
Genus Peptoniphilus
P. asaccharolyticusP. harei
P. lacrimalis
P. ivorii
P. indolicus
Genus Anaercoccus
A. prevotii
A. hydrogenalis
A. tetradius
A. vaginalis
A. lactolyticus
Genus Filifactor
F. alocis (φFusobacterium alocis )Family IV. Eubacteriaceae
Genus Eubacterium
E. saphenum
E. nodatum
E. saburreum
E. sulci (φFusobacterium sulci ) ̆6̆

E. brachy
Genus Mogibacterium
M. timidum
Genus Pseudoramibacter
P. alactolyticus
Family V. Peptococcaceae
Genus Peptococcus
P. niger
FamilyVII. Acidaminococcaceae
Genus Dialister
D. pneumosintes
D.invisus
D.microaerophilusD.propionifaciens
Genus Selenomonas
S. sputigena
S. fluggei
S. infelix
S. noxia
S. dianae
S. artemidis
Genus Veillonella
V. parvula
V. atypica
Class II Mollicutes
Order V.
Incerta sedis
Family Erysiperotrichaceae
Genus Bulleidia
B. extructa
Genus Solobacterium
S. moorei
Class III “Bacilli”
Order I. Bacillales
Family VII. Staphylococcaceae
Genus Staphylococcus
S. saccharolyticus
Genus Gemella
G. haemolysans
G. morbillorum
Order II. Lactobacillales
Family I.
Lactobacillaceae
Genus Lactobacillus
L. salivarius
L. acidophilus
L. brevis
L. caseiL. fermentum
L. plantarum
L. reuteri ̆7̆Phylum BXII Proteobacteria
ClassII. Betaproteobacteria
Order I. Burkholderiales
Family III. Alcaligenaceae
Genus Sutterella
S. wadsworthensis
Order IV. Neisseriales
Family I. Neisseriaceae
Genus Eikenella
E. corrodens
Class IV. Deltaproteobacteria
Order II. Desulfovibrionales
Family I. Desulfovibrionaceae
Genus Desulfovibrio
D. pigerD. desulfuricans
Genus Bilophila
B. wadsworthia

ClassV. Epsilonproteobacteria
Order I. Campylobacterales
Family I. Campylobacteriaceae
Genus Campylobacter
C. gracilis
C. concisus
C. rectus
C. showae
Phylum BXX. Bacteroidetes
Class I. Bacteroidetes
Order I. Bacteroidales
Family I. Bacteroidaceae
Genus Bacteroides
B. fragilis
B. thetaiotaomicron
B. vulgatus
B. uniformis
B. ovatus
B. caccae
B. stercoris
B. nordii
B. salyersiae
B. finegoldii
B. nordii
B. eggerthii“B. ureolyticus”

 ̆8̆Genus Parabacteroides
P. distasonis
P. goldsteinii
P. johnsonii
P. merdae
Genus Megamonas
M. hypermegas
Family III. Porphyromonadaceae
Genus Porphyromonas
P. gingivalis
P. endodontalis
P.bennonis
P. cangingivalis
P. salivosa
P. gulaeP. gingivicanis
Family IV. Prevotella
Genus Prevotella
P. intermedia
P. nigrescens
P. denticola
P. loescheii
P. melannogenica
P. pallens
P. corporis
P. tannerae
P. buccae
P. orisP. oralis
P. veroralis
P. heparinolytica
Class III. Flavobacteria
Family I. Flavobacteriaceae
Genus Capnocytophaga
C. ochracea
Phylum BXXI. Fusobacteria
Class I. Fusobacteria
Order I. Fusobacteriales
Family Fusobacteriaceae
Genus Fusobacterium
F. nucleatum
F. necrophorum
F. varium
F. mortiferum
Genus Leptotrichia
L. buccalis ̆9̆Class I. Actinobacteria
Subclass III. Coriobacteridae
Order I. Coriobacteriales
Suborder I. Coriobacterinae
Family I. Coriobacteriaceae
Genus Atopobium
A. parvulum(φStreptococcus)
A. minutum(φLactobacillus)
A. vaginae
Genus Collinsella
C. aerofaciens
C. stercoris
C. intestinalis
Genus Cryptobacterium
C. curtum
Genus Eggerthella
E. lenta(φEubacterium)
Genus Slackia
S. exigua(φEubacterium )Subclass V. Actinobacteridae
Order I. Actinomycetales
Suborder I. Actinomycineae
Family I. Actinomycetaceae
Genus Actinomyces
A. naeslundii
A. turicensis
A. israelii
A. odontolyticus
A. radingae
Genus Mobiluncus
M. mullieris
M. curtis
Suborder IV. Propionibacterianeae
Family I. Propionibacteriaceae
Genus Propionibacterium
P. acnes
P. avidum
P. granulosum
Order II. Bifidobacteriales
Family I. Bifidobacteriaceae
Genus Bifidobacterium
B. breve
B. longum
B. adolescentis
B. bifidum
B. pseudolongum ̆10̆Genus Falcivibrio
Genus Gardnerella
G. vaginalis
Genus Parascardovia (φBifidobacterium)
P. denticolens
Genus Scardovia (φBifidobacterium)
S. inopinata ̆11̆