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Safety Data Sheet
1. Chemical product and company identification
Product name: TOLUENE

Company information
Name of manufacturer
Address
Name of section
Telephone number
Facsimile number
Mail address
Reference No： KANTO CHEMICAL CO., INC.
： 2-1, Nihonbashi, Muromachi 2-Chome, Chuo-Ku, Tokyo, 103-0022, Japan： Electronic materials division technical department： +81-3-6214-1080： +81-3-3241-1043： el-info@kanto.co.jp: GE00023 1.1

Recommended uses andrestrictions: Electronic chemicals

2. Hazards identification
GHS classification
Physical hazards

Flammable liquids

Category 2

Health hazards

Acute toxicity(inhalation:vapors)

Category 4

Skin corrosion/irritation

Category 2

Serious eye damage/eyeirritation

Category 2B

Environmental
hazards

Reproductive toxicity

Category 1A

Reproductive toxicity (effects
on or via lactation)

Additional category

Specific target organ toxicity(single exposure)

Category 1 (central nervous system)

Specific target organ toxicity(single exposure)

Category 3 (narcosis)

Specific target organ toxicity(single exposure)

Category 3 (respiratory tract irritation.)

Specific target organ toxicity(repeated exposure)

Category 1 (central nervous system, kidney)

Aspiration hazard

Category 1

Aquatic acuteCategory 2

Aquatic chronic

Category 3Hazard
pictograms

Signal word:

DangerHazard statements:

Highly flammable liquid and vapor
May be fatal if swallowed and enters airways
Causes skin and eye irritation

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Harmful if inhaled
May cause respiratory irritation
May cause drowsiness or dizziness
May damage fertility or the unborn child
May cause harm to breast-fed children
Causes damage to organs (central nervous system)
Causes damage to organs (central nervous system, kidney) throughprolonged or repeated exposure
Toxic to aquatic life
Harmful to aquatic life with long lasting effects
Precautionary statements
Prevention:

Do not handle until all safety precautions have been read andunderstood.
Keep away from heat, hot surfaces, sparks, open flames and otherignition sources. No smoking.
Keep container tightly closed.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use only non-sparking tools.
Take action to prevent static discharges.
Do not breathe mist/vapors.
Avoid contact during pregnancy and while nursing.
Wash hands, forearms and face thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Avoid release to the environment.
Wear protective gloves/protective clothing/eye protection/faceprotection.

Response:

IF SWALLOWED: Immediately call a POISON CENTER or doctor.
IF ON SKIN: Wash with plenty of water.
IF ON SKIN (or hair): Take off immediately all contaminatedclothing. Rinse skin with water .
IF INHALED: Remove person to fresh air and keep comfortable forbreathing.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
IF exposed or concerned: Call a POISON CENTER or doctor.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER or doctor if you feel unwell.
Get medical advice/attention if you feel unwell.
Do not induce vomiting.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.

Storage:

Store in a well-ventilated place. Keep container tightly closed.
Store in a well-ventilated place. Keep cool.
Store locked up.

Disposal:

Dispose of contents/container to hazardous or special waste
collection point, in accordance with local, regional, national
and/or international regulation.

3. Composition/information on ingredients
Distinction of substance ormixture:

Substance<< GE00023 TOLUENE >>

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Synonyms
Chemical name
Toluene:

Methylbenzene

Concentration (%)
min. 99.5

FormulaC6H5CH3

TSCA
ListedEC-No.
203-625-9

CAS RN
108-88-3

4. First aid measures
First aid measures
First-aid measures afterinhalation:

Remove the victim to fresh air, and make him blow his nose andgargle. If necessary, get medical treatment.

First-aid measures after skincontact:

Wash the affected areas under running water.

First-aid measures after eyecontact:

Wash the affected areas under running water for at least 15
minutes. If necessary, get medical treatment.

First-aid measures afteringestion:

The chemical is volatile. Do not induce vomiting because it
increases the risk of aspiration into the lungs. Get medical
attention immediately. If necessary, rinse mouth with water.

Personal Protection in FirstAid and Measures:

Rescuers should wear proper protective equipment like rubber
gloves, goggles.

Suitable extinguishing media:

Dry chemical powder, carbon dioxide, dry sand, foam

Unsuitable extinguishing media:

Water spray

Firefighting instructions:Move containers from fire area if it can be done without risk, if
not possible, apply water from a safe distance to cool andprotect surrounding area.

5. Fire fighting measures

Fight fire from windward.
Dry chemical powder, carbon dioxide or dry sand should be used
for small fires. Foam extinguisher is effective for a large scale
fire.
Personal protection (Emergencyresponse):

Wear breathing apparatus.

6. Accidental release measures
Personal Precautions, Protective Equipment and Emergency Procedures
General measures:

Wear proper protective equipment and avoid contact with skin andinhalation of vapor. Conduct operations from upwind and evacuate
people downwind. Remove all sources of ignition. Keep away
personnel except for authorized ones from spillage area by
stretching ropes.

:

Attention should be given to avoid damage to the environment byflowing of spillage to rivers.

Environmental precautions
Environmental precautions

Methods and Equipment for Containment and Cleaning up
For containment:

Absorb spill with inert material （e.g, diatomaceous earth,sand） and flush spillage area with copious amounts of water.

Prevention Measures for
Secondary Accidents:

Remove nearby sources of ignition and prepare extinguishingmedia.

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7. Handling and storage
Handling
Technical measures:

As toluene has easily static electricity, earth the pipes, hoses,
bottles when transporting.
Wear proper protective equipment to avoid contact with skin orinhalation of vapor. Fire is strictly prohibited.
Ventilate well at working places.

Precautions for safe handling:

Use with an enclosed system or a local exhaust ventilation. Usein well-ventilated areas.
Do not allow contact with oxidizing substances.

Storage
Storage conditions:Store in a dark, cool place and tightly closed.

Material used inpackaging/containers:Glass, SUS.
Do not use vinyl chloride resin, acrylic resin, polystyrene etc.

8. Exposure controls / Personal protection equipment
ACGIH TWA

20 ppmAppropriate engineering
controls
Protective equipment: Use with an enclosed system or a local exhaust ventilation.

Respiratory protection: Chemical cartridge respirator with an organic vapor cartage orairline respirator

Hand protection: Impervious protective gloves

Eye protection: Safety goggles

Skin and body protection: Protective clothing, protective boots

9. Physical and chemical properties
Physical state: LiquidColor: Colorless.

Odor: AromaticpH: No data available

Melting point: -95 °C

Freezing point: No data available

Boiling point: 110.6 °C

Flash point: 4.4 °C (C.C.)

Auto-ignition temperature: 536 °C

Decomposition temperature: No data available

Flammability: Flammable

Vapor pressure: 13.3 hPa (27℃)

Relative density: No data available

Density: 0.867 g/cm³ (20℃)

Relative gas density: 3.2Solubility: Organic solvents: Miscible with many kinds of organic solvents.
Water: 0.045 % (20℃): 2.69Partition coefficient n-<< GE00023 TOLUENE >>

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octanol/water (log Pow)
Explosive limits (vol %): 1.2 – 7.1 vol %Viscosity, kinematic:: 0.86 mm²/s (40℃)

Particle characteristics: No data available

10. Stability and reactivity
Reactivity: Oxidation with potassium dichromate or the like produces benzoicacid.
Reduction with a platinum catalyst or the like producesmethylcyclohexane.

Chemical stability: Stable under normal conditions.

Possibility of hazardous
reactions: May react violently when in contact with oxidaizing substance.

Conditions to avoid: Light, heat.

Incompatible materials: Oxidizing substances.

Hazardous decomposition
products: Carbon monoxide.

11. Toxicological information
Acute toxicity (oral)
Acute toxicity (dermal)
Acute toxicity (inhalation): No classification
rat LD50=5000mg/kg: No classification
rat LD50=12000mg/kg: No classification (gas)Harmful if inhaledClassification not possible (dust, mist): rat LC50=4000ppm/4h

Acute toxicity (vapor) Description
Skin corrosion/irritation:

Serious eye damage/irritation:

Respiratory sensitization
Skin sensitization::

Causes skin irritation
In a semi-occlusive application test in which the substance 0.5mL
was applied to seven rabbits for 4 hours, by 72 hours all animals
exhibited erythema, ranging from very slight to severe, and slightoedema. On day 7, erythema ranged from well-defined to severe for
all animals, and oedema ranged from very slight to slight for 5animals. Thus, the substance was classified into category 2 basedon evidence of moderate irritation.
Causes eye irritation
In an ocular irritation test in which the substance 0.1mL wasapplied to six rabbits, redness, chemosis, and discharge wereobserved in all six animals 1 hour after exposure, and the symptoms
persisted 24, 48 hours after exposure, and then irritation
decreased. Only redness was observed 72 hours after exposure, andall animals were free of ocular irritation on day 7. Thus, thesubstance was classified into category 2B based on evidence of mildirritation.
Classification not possible
No classification
No skin sensitization by maximization test with guinea pig.

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Germ cell mutagenicity:

Carcinogenicity:

Reproductive toxicity:

STOT-single exposure:

STOT-repeated exposure:

Aspiration hazard:

No classification
There are two negative data on dominant lethal studies in mice byoral or inhalation administration (germ cell mutagenicity tests invivo), five negative data on chromosome aberration tests in mouseor rat bone-marrow cells by oral, inhalation or intraperitonealadministration (somatic cell mutagenicity tests in vivo), and two
negative data on micronucleus examinations in mouse bone-marrowcells by oral or intraperitoneal administration (somatic cellmutagenicity tests in vivo).
No classification
IARC classifies it as group 3(not classifiable as to its
carcinogenicity to humans).
May damage fertility or the unborn child
May cause harm to breast-fed children
Human epidemiological studies suggest increased incidence of
natural abortion after toluene exposure, abnormal development andmalformation of newborns caused by prenatal toluene abuse anddecreased plasma concentrations of luteinizing hormone andtestosterone after toluene exposure. Based on the description that
"toluene easily crosses the placenta and is secreted into breast
milk", "Additional category: Effects on and via lactation" wasadded.
Causes damage to organs (central nervous system)
May cause drowsiness or dizziness
May cause respiratory irritation
Human studies have shown that following inhalation exposure to750mg/m3 for 8 hours, muscle weakness, confusion, dyssynergia, andmydriasis were noted, and at 3000ppm, severe fatigue, marked
nausea, and mental confusion were noted, and severe incidental
exposure resulted in coma. In addition, there are many reports thatthe substance adversely affects central nervous system. Thus, it
was classified into category 1 (central nervous system). Meanwhile,
it is well known that acute exposure of humans to highconcentrations of the substance easily causes anesthetic actions,and there are many cases of workers who lost consciousness due tothe substance vapor. Moreover, there is animal evidence ofanesthetic actions following inhalation exposure to mice or rats.
Thus, it was classified into category 3 (narcosis). Furthermore,human volunteers exposed to a low concentration (200ppm) developed
transient, mild upper respiratory irritation. Thus, it wasclassified into category 3 (respiratory tract irritation).
Causes damage to organs (central nervous system, kidney) throughprolonged or repeated exposure
Based on the human evidence including toluene induces drug
dependency, and inhalant abuse of toluene causes chronic central
nervous system damage including restricted vision, headache
associated with nystagmus and hearing loss, tremor, ataxia andamnesia. Futhermore renal dysfunction manifested as proteinuria andhematuria was also observed. Thus, it was classified into category
1 (central nervous system, kidney).
May be fatal if swallowed and enters airways
Since toluene is a hydrocarbon and its dynamic viscosity is
0.86mm2/S (40 ℃), it is classified into category 1.

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12. Ecological information
Ecotoxicity
Aquatic acute
Aquatic chronic: Toxic to aquatic life
Ceriodaphnia dubia EC50=3.78mg/L/48h: Harmful to aquatic life with long lasting effects
Ceriodaphnia dubia NOEC=0.74mg/L/7-day

Persistence and degradability
Readily biodegradable
BOD : 123%
Bioaccumulative potential
Low bioconcentrationlog Pow : 2.69
Mobility in soil
Moderate mobility
Koc : 270
Hazardous to the ozone layer
Ozone: Classification not possible

13. Disposal considerations
Ecological waste information: Burn in a chemical incinerator equipped with an afterburnerand a scrubber. Or entrust approved waste disposal companies
with the disposal.

Contaminated container andpackaging: In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea(IMDG)
UN-No. (IMDG)
Proper Shipping Name (IMDG)
Packing group (IMDG)
Transport hazard class(es)(IMDG)Air transport(IATA)
UN-No. (IATA)
Proper Shipping Name (IATA)
Packing group (IATA)
Transport hazard class(es)(IATA)::::

1294
TOLUENE
II
3:::
:

1294
TolueneII3

Marine pollutant: Not applicable
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Pollutant category:Y
MFAG-No:130

15. Regulatory information
Regulatory information with regard to this substance in your country or region should be examined byyour own responsibility.

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16. Other information
Data sources: Dictionary of Organic Compounds, The society of Synthetic
Organic Chemistry, Kodansha Ltd.（1985）.
Dangerous Properties of Industrial Materials,6th ed.
N.I.Sax Van Nostrand Reinhold Company（1984）.
Handbook of Dangerous Substances Springer-Verlag Tokyo（1991）.
Handbook of 17322 Chemical Products, The Chemical Daily Co.
（2022）.
NITE Chemical Risk Information Platform (NITE-CHRIP), National
Institute of Technology and Evaluation.

The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully.The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements.The information herein is only provision of information, andit does not represent a guarantee the properties of the product.The Safety Data Sheet(SDS) isprepared based on JIS Z7253.