病態分子イメージングセンターに係る業績
講座等名

外科学講座

事業推進者名海堀昌樹＜雑誌論文＞（著者名・論文標題・雑誌名・レフェリー有無・巻・ページ・発行年）
以下論文は全てレフェリー有り①
1.
Miki H, Tokuhara K, Oishi M, Tanaka Y, Nakatake R, Ueyama Y, Kaibori M, Nishizawa M, Okumura T,Kon M. Elental® amino acid component has protective effects on primary cultured hepatocytes and a rat
model of acute liver injury. Nutrition Research, in press (5-1-2017). Nutrition Research, 2017; 42: 71-84.
2.
Tsuda T, Kaibori M, Hishikawa H, Nakatake R, Okumura T, Ozeki E, Hara I, Morimoto Y, Yoshii, Kon M.
Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosome has
antineoplastic effects for hepatocellular carcinoma. PLoS One. 2017 Aug 31;12(8):e0183527.
3.
Fujii A, Okuyama T, Wakame K, Okumura T, Ikeya Y, Nishizawa M. Identification of anti-inflammatory
constituents in phellodendri cortex and coptidis rhizoma by monitoring the activity to suppression of nitricoxide production. J Nat Med. 2017; 71(4): 745-756.
4.
Nakatake R, Hishikawa H, Matushima H, Nakamura Y, Ishizaki M, Matsui K, Kaibori M, Nishizawa M,
Okumura T, Kon M. Curcumin protects liver inflammation by suppressing expression of inducible nitricoxide synthase in primary cultured rat hepatocytes. Functional Foods in Health and Disease, 2017; 7(9);716-734.
5.
Okuyama T, Nakatake R, Kaibori M, Okumura T, Kon M, Nishizaw M. A sense oligonucleotide to inducible
nitric oxide synthase mRNA increases the survival rate of rats in septic shock. Nitric Oxide, 2018; 72:
32-40.
6.
Nakatake R, Kaibori M, Nakamura Y, Tanaka Y, Matushima H, Okumura T, Murakami T, Ino Y, Todo T, Kon
M. A third-generation oncolytic herpes simplex virus inhibits the growth of liver tumors in mice. Cancer
Res. 2018; 109; 600-610.
7.
Nakatake R, Iida H, Ishizaki M, Matsui K, Nakamura Y, Kaibori M, Nishizawa M, Okumura T. Metformin
inhibits expression of the proinflammatory biomarker inducible nitric oxide synthase in hepatocytes.
Functional Foods in Health and Disease, 2018; 8(3): 175-192.
8.
Nakamura Y, Iida H, Nakatake R, Sakaguchi T, Kaibori M, Okumura T, Hamada Y, Doi T. L-Carnitine has aliver-protective effect through inhibition of inducible nitric oxide synthase induction in primary cultured rat
hepatocytes. Functional Foods in Health and Disease, 2018; 8(3): 212-227.
9.
Nakatake R, Kotsuka M, Hashimoto Y, Hatta M, Ishizaki M, Matsui K, Kaibori K, Nishizawa N, Okumura T.
Glutathione inhibits expression of the proinflammatory biomarker inducible nitric oxide synthase inhepatocytes. Functional Foods in Health and Disease, 2018; 8(10): 495-509.
10. Yamauchi Y, Okuyama T, Ishii T, T, Okumura T, Ikeya Y, Nishizawa M. Sakuranetin downregulates
inducible nitric oxide synthase expression by affecting interleukin-1 receptor and CCAAT/enhancer-binding
protein β. J Nat Med. 2019; 73(2): 353-368.
11. Dwijayanti DR, Okuyama T, Okumura T, Ikeya Y, Nishizawa M. The anti-inflammatory effects ofIndonesian and Japanese bitter melon (Momordica charantia L.) fruit extracts on interleukin-1β-treatedhepatocytes. Functional Foods in Health and Disease, 2019; 9(1): 16-33.
12. Sakaguchi T, Hashimoto Y, Matsushima H, Hishikawa H, Nishizawa N, Okumura T, Kaibori M.
Levosimendan pretreatment improves survival of septic rats after partial hepatectomy and suppresses iNOS
induction in cytokine-stimulated hepatocytes. Scientific Reports; accepted 1-9-2019.
13. Nishizawa M, Okumura T, Ikeya Y. Assessment of anti-inflammatory effects of Japanese Kampo medicine
versus functional foods. Functional Foods in Health and Disease, 2019; 9(2): 79-91.
14. Nakatake R, Hishikawa H, Kotsuka M, Ishizaki M, Matsui K, Nishizawa M, Yoshizawa K, Kaibori M,Okumura T. The proton pump inhibitor lansoprazole has hepatoprotective effects in in vitro and in vivo rat
models of acute liver injury. Digestive Diseases and Sciences, accepted 4-6-2019.
15. Ueyama Y, Tokuhara T, Miki H, Nakatake R, Sakaguchi T, Nishizawa M, Kaibori M, Okumura T. AHCC®
has protective effects in ischemia-reperfusion injury of the rat small intestine. J Surg Res, accepted
5-30-2019.
16. Hishikawa H, Kaibori M, Tsuda, T, Matsui K, Okumura T, Ozeki E, Yoshii K. Near-infrared fluorescenceimaging and photodynamic therapy with indocyanine green lactosomes has antineoplastic effects forgallbladder cancer. Oncotarget, accepted 6-16-2019.
②1.
Tsuda T, Kaibori M, Hishikawa H, et al. Near-infrared fluorescence imaging and photodynamic therapy withindocyanine green lactosome has antineoplastic effects for hepatocellular carcinoma. PLoS One. 2017; 31; 12(8):e0183527. doi:
＜図書＞（著者名・出版社・書名・発行年・総ページ数）無し＜学会発表＞（発表者名・発表標題・学会名・開催地（海外の場合は匡名と都市名）・発表年月）①2017 (H29)1.

Richi Nakatake, Hidehiko Hishikawa, Hideyuki Matushima, Yusuke Nakamura, Morihiko Ishizaki, KosukeMatsui, Masaki Kaibori, Mikio Nishizawa, Tadayoshi Okumura, A-Hon Kwon.
Curcumin protects liver inflammation by suppressing iNOS induction in rat hepatocytes.
39th ESPEN Congress on Clinical Nutrition and Metabolism (Hague, The Netherlands; September 9-12,2017)2.

Richi Nakatake, Yoshito Tanaka, Yousuke Ueyama, Hirokazu Miki, Morihiko Ishizaki, Kosuke Matsui,
Masaki Kaibori, Tadayoshi Okumura, Masanori Kon.
Alleviating effect of active hexose correlated compound prevents endotoxin-induced liver injury afterpartial hepatectomy in rats.
25th ICNIM (Internal Congress of Nutrition and Integrative Medicine) (Sapporo, Japan; July 8-9, 2017)3.

Yukinobu Ikeya, Sayuri Yokoyama, Yuka Yamamoto, Tetsuya Okuyama, Tadayoshi Okumura, Mikio
Nishizawa.
Constituents in perilla extract inhibit production of nitric oxide in rat hepatocytes.
25th ICNIM (Internal Congress of Nutrition and Integrative Medicine) (Sapporo, Japan; July 8-9, 2017)

4.

Dinia R. Dwijayanti, Tetsuya Okuyama, Tadayoshi Okumura, Yukinobu Ikeya, Mikio Nishizawa. Effects ofthe Extracts from Indonesian and Japanese Bitter Melons on the Nitric Oxide Production in Hepatocytes.
25th ICNIM (Internal Congress of Nutrition and Integrative Medicine) (Sapporo, Japan; July 8-9, 2017)5.

山内 優子, 奥山 哲矢, 奥村 忠芳, 池谷 幸信, 西澤 幹雄
ラット初代培養肝細胞におけるオウヒ成分の NF-κB シグナル伝達経路への影響
第 40 回分子生物学会（第 90 回日本生化学会）神戸、12 月 6−9 日、2017.

6.

石井 寿成, 奥山 哲矢, 奥村 忠芳, 池谷 幸信, 西澤 幹雄
ソウジュツ中に含まれる一酸化窒素産生誘導を抑制する成分の探索
第 40 回分子生物学会（第 90 回日本生化学会）神戸、12 月 6−9 日、2017.

2018 (H30)
7.

Dinia R. Dwijayanti, Tetsuya Okuyama, Tadayoshi Okumura , Yukinobu Ikeya, Mikio Nishizawa.

The anti-inflammatory effects of Indonesian and Japanese bitter melon (Momordica charantia L.)
extracts in interleukin-1β-treated hepatocytes.
25th International Conference of Functional Food Center (Ibaraki, Japan, October 27-28, 2018)8.

Mikio Nishizawa, Tadayoshi Okumura, Yukinobu Ikeya.
Assessment of anti-inflammatory effects of Japanese Kampo medicine and functional foods.
25th International Conference of Functional Food Center (Ibaraki, Japan, October 27-28, 2018)9.

Richi Nakatake, Masaya Kotsuka, Yuki Hashimoto, Masahiko Hatta, Morihiko Ishizaki, Kosuke Matsui,Masaki Kaibori, Mikio Nishizawa, Tadayoshi Okumura.
Glutathione inhibits the expression of proinflammatory biomarker inducible nitric oxide synthase inhepatocytes.
25th International Conference of Functional Food Center (Ibaraki, Japan, October 27-28, 2018)10.

Yusuke Nakamura, Hiroya Iida, Richi Nakatake, Tatsuma Sakaguchi, Masaki Kaibori, Tadayoshi Okumura,Yoshinori Hamada, Takashi Doi.
L-Carnitine inhibits induction of inducible nitric oxide synthase gene expression in hepatocytes.
25th International Conference of Functional Food Center (Ibaraki, Japan, October 27-28, 2018)11.

Richi Nakatake, Hidehiko Hishikawa, Hideyuki Matushima, Masaya Kotsuka, Morihiko Ishizaki, Kosuke
Matsui, Hiroaki Yanagimoto, Masaki Kaibori, Mikio Nishizawa, Tadayoshi Okumura.
Curcumin protects liver inflammation by suppressing iNOS induction in rat hepatocytes.
26th ICNIM (Internal Congress of Nutrition and Integrative Medicine) (Sapporo, Japan; July 21-22,2018)12.

Tetsuya Okuyama, Chisa Takakura, Takae Kamimoto, Tadayoshi Okumura, Yukinobu Ikeya, Mikio
Nishizawa.
Effects of the wolfberry (the fruits of Lycium barbarum) and their constituent on nitric oxideproduction in interleukin-1β treated rat hepatocytes.
26th ICNIM (Internal Congress of Nutrition and Integrative Medicine) (Sapporo, Japan; July 21-22,2018)13.

Yukinobu Ikeya, Sayuri Yokoyama2, Tetsuya Okuyama, Tadayoshi Okumura, Mikio Nishizawa.
Constituents in Perilla Extract Inhibit Production of Nitric Oxide in Rat Hepatocytes.
26th ICNIM (Internal Congress of Nutrition and Integrative Medicine) (Sapporo, Japan; July 21-22,2018)

14.

Masaya Kotsuka, Richi Nakatake, Yuki Hashimoto, Masaki Kaibori, Mikio Nishizawa, Tadayoshi Okumura.
Glutathione inhibits expression of the proinflammatory biomarker inducible nitric oxide synthase inhepatocytes.
40th ESPEN Congress on Clinical Nutrition and Metabolism (Madrid, Spain, 1-4 September, 2018)15.

Richi Nakatake, Hiroya Iida, Morihiko Ishizaki , Kosuke Matsui, Yusuke Nakamura, Masaki Kaibori, Mikio
Nishizawa , Tadayoshi Okumura.
Metformin has a protective effect through the inhibition of inducible nitric oxide synthase gene
expression in hepatocytes.
40th ESPEN Congress on Clinical Nutrition and Metabolism (Madrid, Spain, 1-4 September, 201②
1.菱川秀彦・高分子ミセル化 ICG を用いた胆嚢癌診断・治療の検討・蛍光 Navigation Surgery 研究会・
東京・2018 年 4 月
2.菱川秀彦・高分子ミセル化 ICG を用いた胆嚢癌診断・治療の検討・日本外科学会・大阪・2019 年 4月

＜特許申請・取得状況＞
無し