৴ᆢ་ॺ ஸ့ଞ੄ࢇ

ऎॺଞ੄ৰᄯ‫״بװ‬՛

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ˋԧ
ᇹᵏᵗӭ ˋԧᵒ࠰ᵑஉDĂƌĐŚ͕ ϮϬϮϮԙԺԶԵӨԢԳԺԵՂԳԵӨԡԵՇԵԱՆԳԸӨԍԵՂՈԵՆ
ԑԺԶՉӨԤՂԺՊԵՆՇԺՈՍ
ԸՈՈՄՇԄӹӹՋՋՋӻӸԷԺԶՉӷՉӸԱԳӸԻՄӹԾՀՇՆԳӹ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᖺሗ➨ 19 ྕ┠ḟᒱ㜧኱Ꮫࡢ◊✲ᇶ┙ࡢࡉࡽ࡞ࡿⓎᒎ࡟ᮇᚅࡋ࡚
ᒱ㜧኱Ꮫ㛗 ྜྷ⏣࿴ᘯ⛉Ꮫ◊✲ᇶ┙ࢆᥦ౪ࡍࡿඹྠ฼⏝᪋タࡢࡉࡽ࡞ࡿⓎᒎࢆ┠ᣦࡋ࡚⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗 ஧ୖⱥᶞࢭࣥࢱ࣮ࡢ⌮ᛕ࡜┠ⓗ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭
࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

ࢭࣥࢱ࣮ࡢ᠇❶࣭ᇶᮏᡓ␎
ࢭࣥࢱ࣮⤌⧊ᅗ
ࢭࣥࢱ࣮ἢ㠉

ࢭࣥࢱ࣮ྛศ㔝ᡤᅾᆅ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

 ᖺᗘάື≧ἣሗ࿌࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

 ᖺᗘᨭ᥼≧ἣ ᖺᗘᒱ㜧኱Ꮫබ㛤ㅮᗙ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ᒱ㜧኱Ꮫ㧗➼◊✲㝔つ⛬࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮⣽๎࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㐠Ⴀጤဨ఍せ㡯࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟せ㡯࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ศ㔝ࡈ࡜ࡢሗ࿌
‫✲◊࣒ࣀࢤ ی‬ศ㔝࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫≀ື ی‬ᐇ㦂ศ㔝࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫ ی‬ᶵჾศᯒศ㔝࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫ ی‬᎘Ẽᛶ⳦◊✲ศ㔝࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫ ی‬ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝‫ ی‬ᢠ㓟໬◊✲㒊㛛ᐊࡈ࡜ࡢሗ࿌‫ ە‬㧗➼◊✲㝔㑇ఏᏊ᳨ᰝᐊ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫✲◊ ە‬ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

‫࢕ࢸࣜࢩ࢓ࣇ࢔ࢥ ە‬ᶵჾඹ⏝㐃ᦠᐊ⦅㞟ᚋグᒱ㜧኱Ꮫࡢ◊✲ᇶ┙ࡢࡉࡽ࡞ࡿⓎᒎ࡟ᮇᚅࡋ࡚
ᒱ㜧኱Ꮫ㛗

ྜྷ⏣࿴ᘯ

ᡃ䛜ᅜ䛷䛿㧗㱋໬♫఍䜢㏄䛘䚸䝁䝻䝘᪂᫬௦䛷䛾᪂䛯䛺♫఍䛂Society 5.0䛃䛾ᐇ⌧䛻ྥ䛡䛶ᡓ␎䜢䛯䛶䚸䜰䜽䝅䝵䞁䝥䝷䞁䜢ᐇ⾜䛧䛶䛔䜎䛩䚹ᅜ❧኱Ꮫ䛷䛿䚸ᅜ㝿༟㉺◊✲኱Ꮫ䛸ᆅᇦ୰᰾኱Ꮫ䛸䛔䛖ᴫᛕ䜢᪂䛯䛻๰ฟ䛧䚸ᅜ❧኱Ꮫ◊✲ຊᙉ໬䛻ྥ䛡䛶⯦䜢䛝䜚䜎䛧䛯䚹ᒱ㜧኱Ꮫ䛿୰㒊ᆅ༊䛻䛚䛡䜛୰つᶍ⥲ྜ኱Ꮫ䛷䚸Ꮫෆ䛻ᕤᏛ㒊䚸ᛂ⏝⏕≀⛉Ꮫ㒊䞉⋇་Ꮫ⛉䚸་Ꮫ㒊䛺䛹䛾⮬↛⛉Ꮫ⣔䛾Ꮫ㒊䜢᭷䛧䛶䛚䜚䜎䛩䚹䛂䜒䛾䛵䛟䜚䛃䛂㣗䛵䛟䜚䛃䛂᪂䛯䛺་⒪䛵䛟䜚䛃䛭䛧䛶䚸䛂⏫䛵䛟䜚䛃䛂ே䛵䛟䜚䛃䛻㈉⊩ฟ᮶䜛ேᮦ䛾⫱ᡂ䜢ᚓព䛸䛧䛯ᆅᇦ୰᰾኱Ꮫ䛷䛩䚹ᩜᆅෆ䛻䛿ᒱ㜧ᕷ❧ᒱ㜧⸆⛉኱Ꮫ䚸ᒱ㜧┴୰ኸᐙ␆ಖ೺⾨⏕ᡤ䚸ᒱ㜧┴㣗ရ⛉Ꮫ◊✲ᡤ䛺䛹኱Ꮫእ䛾◊✲ᶵ㛵䜒ྠᒃ䛧䛶䛔䜎䛩䚹2020 ᖺ 4 ᭶䜘䜚䚸ྡྂᒇ኱Ꮫ䛸ἲே⤫ྜ䛧ᮾᾏᅜ❧኱Ꮫᶵᵓ䛸䛧䛶䚸ᡃ䛜ᅜ᪂䛯䛺኱Ꮫ䛾┠ᣦ䛩䝰䝕䝹䛸䛧䛶䚸⏕䜎䜜ኚ䜟䜚䜎䛧䛯䚹䛭䛧䛶䚸䛂ୡ⏺䜢䝸䞊䝗䛧ᆅᇦኚ㠉䜢≌ᘬ䛩䜛䛃䛣䛸䛷䚸䛂ୡ⏺䛸ః䛩䜛▱䛾ᣐ
Ⅼ䛃䛸䛧䛶ά㌍䛩䜛஦䜢┠ᣦ䛧䛶䛔䜎䛩䚹䛣䛾⤫ྜ䛻䜘䜚◊✲ຊ䛾ᙉ໬䛜ᮇᚅ䛥䜜䚸䛭䛾୍䛴䛸䛧䛶ྡྂᒇ኱Ꮫ䛸ྜྠ䛾⢾㙐⏕࿨䝁䜰◊✲ᡤ䜒Ⓨ㊊䛧䜎䛧䛯䚹⌧ᅾ䛾ᒱ㜧኱Ꮫ䛿䚸䛣䜜䜙ᵝ䚻䛺◊✲⤌⧊䛜䜻䝱䞁䝟䝇䛻㞟⣙䛧䚸┦஫䛻஺ὶ䛧◊✲䜢᥎㐍䛩䜛䛣䛸䛻䜘䜚䚸ᒱ㜧┴䛻䛚䛡䜛⏕࿨⛉Ꮫ◊✲䛾୍኱ᣐⅬ䛸䛺䛳䛶䛔䜎䛩䚹௨ୖ䛾䜘䛖䛺⛉Ꮫ䛾◊✲䛻䛿ከ኱䛺◊✲㈨㔠䛸㧗ᗘ䛺᭱᪂◊✲ᶵჾ䛜ᚲせ䛷䛩䛜䚸䛭䜜䛻ᛂ䛘䜛䜘䛖䛻䛧䛶᭱ඛ➃䛾ᶵჾ䛾⟶⌮㐠Ⴀ䜢⾜䛳䛶䛝䛯䛾䛜䚸⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊䛷䛩䚹䛣䛾䜘䛖䛺ඛ➃ⓗ䛺ᶵჾ䜢ඹྠ฼⏝䛩䜛௙⤌䜏䜢ᙉ໬䛩䜛ྲྀ䜚⤌䜏䜢䝁䜰䝣䜯䝅䝸䝔䜱໬䛸࿧䜃䜎䛩䛜䚸ᒱ㜧኱Ꮫ䛷䛿 2003 ᖺ䛻ඹྠ฼⏝᪋タ䛸䛧䛶ᮏ䝉䞁䝍䞊䜢タ⨨䛧䚸᪩䛟䛛䜙ྲྀ䜚⤌䜣䛷䛝䜎䛧䛯䚹䛣䜜䜎䛷㛗䛝䛻Ώ䜚䚸ᒱ㜧኱Ꮫ䛻䛚䛡䜛ྛ◊✲⪅䛾䝙䞊䝈䛻ᛂ䛘䚸⣲ᬕ䜙䛧䛔ᴗ⦼䛾ᇶ┙䜢ᥦ౪䛧䛶䛝䜎䛧䛯䚹䝉䞁䝍䞊䛻䛿䚸⟶⌮䛩䜛ᶵჾ䜔タഛ䚸ᥦ౪䛩䜛䝃䞊䝡䝇䛤䛸䛻ู䜜䛯䝀䝜䝮◊✲ศ㔝䚸᎘Ẽᛶ⳦◊✲ศ㔝䚸ື≀ᐇ㦂ศ㔝䚸ᶵჾศᯒศ
㔝䚸ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝䛜タ⨨䛥䜜䛶䛔䜎䛩䚹ᮏᇶ┙䝉䞁䝍䞊䛻䛿䚸⚾ಶே䜒◊✲⪅䛸䛧䛶䚸䛂⒴䛾䝀䝜䝮ゎᯒ䛃䜔䛂ᢠ䛜䜣๣⪏ᛶ䛻䛚䛡䜛 mRNA 䛾⥙⨶ⓗ䛺Ⓨ⌧ゎᯒ䛃䚸䛥䜙䛻䛿䛂᪂䛯䛺ᢠ䛜䜣స⏝䜢᭷䛩䜛ᑠศᏊ䛾᥈⣴䛃䛺䛹䛷䛚ୡヰ䛻䛺䜚䜎䛧䛯䚹2021
ᖺ 3 ᭶䛻㑇ఏᏊ᳨ᰝᐊ䛜Ⓩ㘓⾨⏕᳨ᰝᡤ䛻ㄆྍ䛥䜜䚸ᣦᐃ㞴⑓䛷䛒䜛๪⭈ⓑ㉁䝆䝇䝖䝻䝣䜱䞊䜔䝨䝹䜸䜻䝅䝋䞊䝮⑓䛾デ᩿ᣐⅬ䛸䛧䛶♫఍㈉⊩䜢୍ᒙຍ㏿䛷䛝䛯䛾䜒䚸ᙜ᫬⑓㝔㛗䛸䛧䛶኱ኚ㄂䜚䛷䛒䜚䜎䛧䛯䚹௒ᚋ䜒᭱᪂ᶵჾ䛾ᩚഛ䛻ດ䜑䚸ඛ➃ⓗ◊✲䜢ᨭ䛘䚸ᒱ㜧኱Ꮫ䛾⛉Ꮫ◊✲䛻୍ᒙ㈉⊩䛷䛝䜛䜘䛖䚸ᚰ䜘䜚ᮇᚅ䛧䛶䛔䜎䛩䚹

⛉Ꮫ◊✲ᇶ┙ࢆᥦ౪ࡍࡿඹྠ฼⏝᪋タࡢࡉࡽ࡞ࡿⓎᒎࢆ┠ᣦࡋ࡚⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗஧ୖⱥᶞᖹ⣲䛿⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊䛾ᴗົ䛻䛴䛝䜎䛧䛶䚸䛤⌮ゎ䛸䛤༠ຊ䜢䛔䛯䛰䛝䛒䜚䛜䛸䛖䛤䛦䛔䜎䛩䚹ᖺሗ 19 ྕ䠄௧࿴ 3 ᖺᗘ∧䠅䜢䛚ᒆ䛡䛧䜎䛩䚹ᙜ䝉䞁䝍䞊๓㌟䛿䚸2003 ᖺ䛻⏕࿨⛉Ꮫ⥲ྜᐇ㦂䝉䞁䝍䞊䠄ᚋ䛻⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼䝉䞁䝍䞊䠅䛸䛧䛶タ⨨䛥䜜䛯ඹྠ฼⏝᪋タ䛷䛩䚹䛭䜜䜎䛷䚸ྛ㒊ᒁ䛻ศᩓ䛥䜜⟶⌮䛥䜜䛶䛔䛯᪋タ䛜⤫ྜ䛥䜜䚸඲Ꮫⓗ䛺◊✲ᨭ᥼䛜ྍ⬟䛺䝉䞁䝍䞊䛸䛧䛶㐠⏝䜢㛤ጞ䛧䜎䛧䛯䚹2018 ᖺ䛻䛿䚸ᨵ⤌䛻䜘䜚◊✲᥎㐍ᨭ᥼ᣐⅬ䛾⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊䛸䛺䜚䜎䛧䛯䚹⌧ᅾ䛾䝉䞁䝍䞊䛿䚸䝀䝜䝮◊✲ศ㔝䚸᎘Ẽᛶ⳦ศ㔝䚸ື≀ᐇ㦂ศ㔝䚸ᶵჾศᯒศ㔝䚸ᨺᑕᛶྠ఩ඖ⣲䠄RI䠅ᐇ㦂ศ㔝䛾୺せ 5 ศ㔝䛻ຍ䛘䚸ᢠ㓟໬◊✲㒊㛛䠄ඹྠ◊✲ㅮᗙ䠅䚸◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊ䚸㧗➼◊✲㝔㑇ఏᏊ᳨ᰝᐊ䚸䝁䜰䝣䜯䝅䝸䝔䜱ᶵჾඹ⏝㐃ᦠᐊ䛛䜙ᵓᡂ䛥䜜䚸ᵝ䚻䛺ඹྠ฼⏝䝃䞊䝡䝇䜢Ꮫෆእ䛻ᥦ౪䛧䛶䛔䜎䛩䚹᫖௒䛾◊✲䛷䛿䚸◊✲䛻ᚲせ䛺ᶵჾ䛜㧗ᶵ⬟໬䚸㧗౯᱁໬䛧⟶⌮䛜㞴䛧䛟䛺䜛䛰䛡䛷䛺䛟䚸䛥䜎䛦䜎䛺ἲ௧䜔䜺䜲䝗䝷䜲䞁䛻䜘䜚䝁䞁䝥䝷䜲䜰䞁䝇㑂Ᏺ䛜ᙉ䛟ồ䜑䜙䜜䜛ᵝ䛻䛺䜚䜎䛧䛯䚹ྛศ㔝䞉ྛᐊ䛻䛚䛔䛶䛿䚸◊✲ୖ㛵㐃䛩䜛ἲ௧䜔䜺䜲䝗䝷䜲䞁䜢㑂Ᏺ䛧䛯㐠Ⴀ䛾䜒䛸䚸ᶵჾ䞉タഛ䛾ඹྠ฼⏝䛾䛝䜑⣽䛛䛔⟶⌮䛻䜘䜚䚸฼⏝䛧䜔䛩䛟Ᏻᐃᛶ䛾㧗䛔◊✲䞉ᩍ⫱ᇶ┙䛾ᥦ౪䛻ດ䜑䛶䛔䜎䛩䚹䜎䛯ᡤᒓᩍဨ䛿ᨭ᥼ᴗົ䜢ᢸ䛖䛸䛸䜒䛻⮬䜙䜒◊✲䜢⾜䛔䚸◊✲⪅どⅬ䛛䜙䛾◊✲ᨭ᥼䜢⪃䛘䜛䛺䛹䚸ከ㠃ⓗ䛺ᨭ᥼ᴗົ䛻ᙺ❧䛶䛶䛔䜎䛩䚹
2021 ᖺ䛛䜙䛿䚸඲ᅜඹྠ฼⏝䞉ඹྠ◊✲ᣐⅬ䛷䛒䜛⢾㙐⏕࿨䝁䜰◊✲ᡤ⢾㙐ศᏊ⛉Ꮫ◊✲䝉䞁䝍䞊䛾◊✲ᇶ┙㒊㛛䛸䛧䛶඲ᅜつᶍ䛾ඹྠ฼⏝䝃䞊䝡䝇䜒ᥦ౪䛩䜛䛣䛸䛻䛺䜚䜎䛧䛯䚹௒ᚋ䜒◊✲ᇶ┙䚸◊✲㈨※䜢㏻䛨䛯◊✲䛾άᛶ໬䚸㐃ᦠᙉ໬䛻㈉⊩䛷䛝䜛䝉䞁䝍䞊䛸䛧䛶ດຊ䛧䛶䜎䛔䜚䜎䛩䛾䛷䚸䛤⌮ゎ䛸䛤ᨭ᥼䛾䜋䛹䚸䜘䜝䛧䛟䛚㢪䛔䛧䜎䛩䚹ࢭࣥࢱ࣮ࡢ⌮ᛕ࡜┠ⓗ ᴫせᒱ㜧኱Ꮫ࡟࠾ࡅࡿ⏕࿨⛉Ꮫ◊✲ࢆ✚ᴟⓗ࡟᥎㐍ࡉࡏࡿࡓࡵ࡟ࠊᶵჾࡢඹྠ฼⏝ࡢ㧗ຠ⋡໬࡜㧗⢭ᗘ໬࡟ࡼࡾ⤫ྜⓗ࡞ၥ㢟ゎỴࡢࡓࡵࡢ◊✲ᇶ┙ࢆᩚഛࡋࠊ࠿ࡘேⓗ࣭▱ⓗ஺ὶࡶάⓎ໬ࡋ࡚Ꮫ㒊ࡸᆅᇦࢆ㉺࠼ࡓࣁࣈ࡜ࡋ࡚ࡢ
ᶵ⬟ࢆⓎ᥹࡛ࡁࡿࢭࣥࢱ࣮ࢆ┠ᣦࡍࠋ ◊✲ࡢࢧ࣏࣮ࢺ ඛ➃ⓗ◊✲ࢆᨭ࠼ࡿ኱ᆺᶵჾࡢඹྠ฼⏝㸦ᑟධ࣭⥔ᣢ࣭᭦᪂㸧  ≉ู⟶⌮ࡉࢀࡓᐇ㦂ᐊࡢඹྠ฼⏝ ᩍ⫱ࡢࢧ࣏࣮ࢺ  ᐇ㦂ᢏ⾡ࡢᬑཬ࡜ᩍ⫱◊✲ࡢࣞ࣋ࣝ࢔ࢵࣉ  Ᏻ඲⟶⌮࡜ᩍ⫱カ⦎ ♫఍࡬ࡢ㈉⊩  ᒱ㜧┴ࡢ⛉Ꮫᩍ⫱ࡢᨭ᥼࡜ᕷẸࡢၨⵚάື  ᆅᇦ࡜ࡢ㐃ᦠ࡜࣋ࣥࢳ࣮ࣕࣅࢪࢿࢫࡢ⫱ᡂ 㐠Ⴀ࡟ࡘ࠸࡚  ࢭࣥࢱ࣮άືࡢᏛෆእ࡬ࡢᗈሗ࡜฼⏝࣭ཷクࢧ࣮ࣅࢫࡢᣑ඘  ඹྠࣉࣟࢪ࢙ࢡࢺ࡟ࡼࡿ኱ᆺ◊✲㈝ࡢᑟධ࡜฼⏝㈇ᢸ㔠࣭ཷク◊✲㈝ࡢ᭷ຠ฼⏝ᒱ㜧኱Ꮫ⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮ࡢ᠇❶ࠊᇶᮏᡓ␎ᖹᡂ  ᖺ  ᭶  ᪥࠙᠇❶ࠚᒱ㜧኱Ꮫ࠾ࡼࡧᆅᇦ࡟࠾ࡅࡿ⏕࿨⛉Ꮫࡢᩍ⫱࣭◊✲ᇶ┙ᣐⅬ࡜ࡋ࡚ᶵ⬟ࡍࡿ⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮ࡣᒱ㜧኱Ꮫࡢ⌮ᛕ࡟ᇶ࡙ࡁࠊᏛෆእࡢඹྠ฼⏝᪋タ࡜ࡋ࡚⏕࿨⛉Ꮫศ㔝ࢆྵࡵࡓ⥲ྜⓗ࡞ᩍ⫱࣭◊✲ᇶ┙࡜࡞ࡿタഛࠊᶵჾࢆᩚഛࡋࠊ࠿ࡘேⓗ࣭▱ⓗ஺ὶࡶάⓎ໬ࡋ࡚Ꮫ㒊ࡸᏛෆእࡢᯟࢆ㉺࠼ࡓࠕᆅᇦࡢ▱ࡢᣐⅬࠖ࡜ࡋ࡚ࡢᶵ⬟ࢆ┠ᣦࡍࠋ ඲Ꮫࢆᑐ㇟࡟ࠊ⏕࿨⛉Ꮫࢆྵࡵࡓ⥲ྜⓗ࡞ᑓ㛛▱㆑ࠊᢏ⾡ࢆ⩦ᚓࡋࠊᏳ඲⟶⌮ࠊᩍ⫱カ⦎ࢆ㏻ࡌ࡚㧗ᗘ࡞೔⌮ほࢆ㌟࡟ࡘࡅࡓேᮦࢆ⫱ᡂࡍࡿࠋ࠙⏕࿨⛉Ꮫ࣭Ᏻ඲ᩍ⫱ࠚ ኱Ꮫ࡟࠾ࡅࡿ㧗ᗘ࡞ᩍ⫱࣭◊✲Ỉ‽ࢆ⥔ᣢࡍࡿࡓࡵࠊ⏕࿨⛉Ꮫࡢ◊✲ᇶ┙ࢆ✚ᴟⓗ࡟ᩚഛࡋࠊ඲Ꮫⓗ࡞฼⏝ࢆ᥎㐍ࡍࡿࠋ࠙◊✲ᇶ┙ᩚഛࠚ ⏕࿨⛉Ꮫࢆ㍈࡟Ꮫ㒊ࢆ㉸࠼ࡓ◊✲ࡢ⼥ྜࠊඹྠ◊✲ࡢᒎ㛤ࢆᅗࡾࠊ➇தⓗ◊✲㈨㔠ࡢ⋓ᚓࢆ┠ᣦࡍࠋ࠙඲Ꮫⓗඹྠ◊✲ࡢ᥎㐍ࠚ ኱Ꮫ㝔㐃ྜ࡟✚ᴟⓗ࡟ཧຍࡋࠊᆅᇦࡢ≉ᛶࢆά࠿ࡋࡓ⊂๰ⓗ◊✲ศ㔝ࢆ㛤ᣅࡋࠊ㉁ࡢ㧗࠸◊✲ࢆ᥎㐍ࡍࡿࠋ࠙኱Ꮫ㝔㐃ྜ࡟ࡼࡿඛ➃ᩍ⫱࣭◊✲ࡢ᥎㐍ࠚ ᆅᇦ࡟࠾ࡅࡿ⏕࿨⛉Ꮫศ㔝ࡢᩍ⫱ࠊ◊✲ᇶ┙᪋タ࡜ࡋ࡚ᆅᇦ⛉Ꮫ⏘ᴗࡢ᣺⯆࡟㈉⊩ࡋࠊ◊✲㈨※࣭኱ᆺタഛࡢᏛእ࡬ࡢゎᨺࠊඹྠ࣭ཷク◊✲ࡢᒎ㛤➼ࠊ⏘ᐁᏛࡢ⼥ྜࢆ✚ᴟⓗ࡟㐍ࡵࡿࠋ ࠙ᆅᇦࡢ▱ࡢᣐⅬᙧᡂࠚ ᆅᇦᩍ⫱࡜ᩥ໬࡬ࡢ㈉⊩ࢆ┠ᣦࡋࠊබ㛤ㅮᗙࡸᏛᰯᩍ⫱࡬ࡢ✚ᴟⓗᨭ᥼ࢆ㐍ࡵ࡚ࠊ⛉Ꮫ▱㆑ࡢᕷẸ࡬ࡢၨⵚࢆ
ᅗࡿࠋ࠙ᆅᇦ♫఍ᩍ⫱࣭ᩥ໬࡬ࡢ㈉⊩ࠚ ◊✲ᇶ┙ᩚഛࡢせồ࡟ຍ࠼ࠊ฼⏝⪅㈇ᢸࡸᏛእ฼⏝ࠊᶵჾࡢ෌⏕࣭฼⏝ᣑ኱ࢆ㐍ࡵࠊຠ⋡ⓗ࠿ࡘᡓ␎ⓗ࡞⤒Ⴀ࡜⟶⌮㐠Ⴀࢆ⾜࠺ࠋ࠙⮬ຓດຊ࣭࣮ࣜࣘࢫࡶ㋃ࡲ࠼ࡓᡓ␎ⓗ㐠Ⴀࠚ࠙ᇶᮏᡓ␎ࠚ
1 ᩍ⫱ᇶᮏᡓ␎
࣭⏕࿨⛉Ꮫศ㔝ࡢㅮ⩏࣭ᐇ⩦ࢆ㏻ࡋ࡚඲Ꮫⓗ࡞ᩍ⫱ᨭ᥼ࢆ⾜࠺ࠋ࣭ᩍ⫱┠ᶆ㐩ᡂ࡟ᚲせ࡞ᇶ┙⤒㈝ࢆ☜ಖࡋࠊ㓄ศࡍࡿࠋ࣭ᩍ⫱⎔ቃࢆᩚഛࡋࠊᣑ඘ࡍࡿࠋ
࣭ྛ኱Ꮫ㝔ࡢ࣒࢝ࣜ࢟ࣗࣛ࡟ῧࡗ࡚ࠊᑓ㛛ᩍ⫱ࢆ✚ᴟⓗ࡟༠ຊ࣭ᨭ᥼ࡋࠊ♫఍ࡢせㄳ࡟ᛂ࠼ࡿ㈨㉁⬟ຊࢆᣢࡗࡓᏛ⏕ࢆ⫱࡚ࡿࠋ
࣭ᒱ㜧⸆⛉኱Ꮫ࡜ࡢ㐃ྜ኱Ꮫ㝔ࡢ඘ᐇ࡟✚ᴟⓗ࡟ཧຍࡍࡿ࡜࡜ࡶ࡟ࠊ⏕࿨⛉Ꮫࢆྵࡵࡓ⥲ྜⓗ࡞ᩍ⫱⎔ቃࢆᥦ౪ࡍࡿࠋ

2 ◊✲ᇶᮏᡓ␎
࣭┠ᶆࢆ㧗ࡃࡶࡕࠊୡ⏺ࣞ࣋ࣝࡢ◊✲ࢆ⾜࠺ࠋ࣭◊✲ࡢάᛶ໬ࢆᅗࡾࠊୡ⏺ࢺࢵࣉࣞ࣋ࣝࡢ◊✲ࢆ⫱࡚ࡿࠋ࣭⊂⮬Ⰽࡢ࠶ࡿ◊✲ࢆ㔜どࡋࠊ⥅⥆ࡍࡿࠋ࣭ⱝᡭ◊✲⪅ࢆ㔜どࡋࡓ⤌⧊ᵓᡂ࡟㌿᥮ࢆᅗࡿࠋ
࣭ᡓ␎ⓗ࡟≉Ⰽ࠶ࡿ◊✲ࢆⓎᒎࡉࡏࡿࠋ
࣭ᒱ㜧⸆⛉኱Ꮫ࡜ࡢඹྠ◊✲ࠊ◊✲ᇶ┙ࡢඹྠ฼⏝ࢆ㐍ࡵࡿࠋ࣭㧗࠸ホ౯ࢆཷࡅ࡚࠸ࡿ◊✲ࠊᑗ᮶ᛶࡢ࠶ࡿ◊✲࡟㈨※ࢆ㔜Ⅼⓗ࡟㓄ศࡍࡿࠋ࣭➇தⓗ⎔ቃ࡟ࢳࣕࣞࣥࢪࡍࡿࠋ
࣭⛉Ꮫ◊✲㈝࡟඲ᩍဨࡀ⏦ㄳࡋࠊࡼࡾከࡃࠊࡼࡾ኱ᆺࡢ◊✲㈝ࢆ⋓ᚓࡍࡿࡼ࠺ົࡵࡿࠋ
࣭ᩥ㒊⛉Ꮫ┬௨እࡢࢼࢩࣙࢼࣝࣉࣟࢪ࢙ࢡࢺ࡟ࡶ✚ᴟⓗ࡟ᛂເࡋࠊ㈨㔠ࢆ⋓ᚓࡍࡿࠋ࣭እ㒊㈨㔠ࡢࡓࡵࡢ᝟ሗࢆ཰㞟ࡋࠊ᥎㐍࡟ᚲせ࡞᭱᪂ࡢタഛࢆᩚഛࡋ࡚ᥦ౪ࡍࡿࠋ
࣭඲Ꮫⓗ◊✲ᨭ᥼ࢭࣥࢱ࣮࡜ࡋ࡚ᩚഛࡍࡿࠋ
࣭ᡓ␎ⓗ࣭㛗ᮇⓗ࣭඲Ꮫⓗぢᆅ࠿ࡽ◊✲タഛᩚഛィ⏬㸦࣐ࢫࢱ࣮ࣉࣛࣥ㸧ࢆ❧࡚ࡿࠋ
3 ♫఍㈉⊩ᇶᮏᡓ␎
࣭ࢩ࣮ࢬࡢ㛤Ⓨࠊࢽ࣮ࢬ࡟ᑐᛂࡋ࡚◊✲㈨※ࢆᏛእ࡟ゎᨺࡋࠊ⏘ᴗ࡟㈉⊩ࡍࡿࠋ࣭⏕࿨⛉Ꮫศ㔝ࡢ◊✲ᇶ┙᪋タ࡜ࡋ࡚ᆅᇦࡢ⏘ᴗࡢ᣺⯆࡜Ⓨᒎ࡟㈉⊩ࡍࡿࠋ࣭ᩍ⫋ဨࡣ♫఍㈉⊩࡟✚ᴟⓗ࡟ཧ⏬ࡋࠊᗈ࠸ど㔝࠿ࡽᆅᇦ࡟㈉⊩ࡍࡿࠋ࣭ᆅᇦఫẸ࡟⏕࿨⛉Ꮫ▱㆑࡟ࡘ࠸࡚ࡢၨⵚάືࢆ⾜࠺ࠋ࣭኱Ꮫࡢㅮ⩏ࡸ᪋タ࣭タഛࢆᆅᇦఫẸ࡟㛤ᨺࡋࠊᆅᇦᩥ໬࡟㈉⊩ࡍࡿࠋ࣭ᆅᇦఫẸࡢᩥ໬άື࡜⏕ᾭᩍ⫱࡟ཧຍࡍࡿࠋ
࣭ྛ✀ࡢᏛᰯ࡬ࡢ⏕࿨⛉Ꮫศ㔝ࡢᩍ⫱ᨭ᥼ࢆ⾜࠺ࠋ4 㐠Ⴀᇶᮏᡓ␎
࣭୰ᮇ┠ᶆࠊ୰ᮇィ⏬ࢆ☜ᐇ࡟ᐇ⾜ࡍࡿࠋ࣭ホ౯ࢆ㐠Ⴀ࡟⏕࠿ࡍࠋ
࣭㏱᫂ࠊຠ⋡ⓗࠊ㎿㏿࡞㐠Ⴀࢆࡍࡿࠋ
࣭඲Ꮫⓗ࡞◊✲Ỉ‽ࡢ⥔ᣢࠊྥୖ࡟ᚲせ࡞ᇶ┙ᩚഛࢆせồࡍࡿ࡜࡜ࡶ࡟ࠊ฼⏝⪅㈇ᢸ➼࡟ࡼࡿ⮬ຓດຊࢆ㐍ࡵࠊຠ⋡ⓗ࡞⤒Ⴀࢆ⾜࠺ࠋ࣭᪤Ꮡࡢタഛ࣭ᶵჾࡢ෌⏕ࠊࢿࢵࢺ࣮࣡ࢡ➼࡟ࡼࡿ฼⏝ᣑ኱ࢆ㐍ࡵࠊ࣮ࣜࣘࢫࢆᅗࡿࠋ
࣭እ㒊㈨㔠ࢆ⋓ᚓࡍࡿࡓࡵ኱Ꮫ࡜ࡋ࡚ࡢᡓ␎ࢆᅗࡾࠊ◊✲ᇶ┙᪋タࢆᩚഛࡋᨭ᥼ࡍࡿࠋ
࣭⎔ቃ࡟㓄៖ࡋࡓ㐠Ⴀࢆࡍࡿࠋ

ࢭࣥࢱ࣮⤌⧊ᅗ㸦 㸧ෆࡣෆ⥺␒ྕ㸦௧࿴  ᖺ  ᭶  ᪥ࡲ࡛㸧㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤ ࣀ ࣒ ◊ ✲ ศ 㔝᎘ Ẽ ᛶ ⳦ ◊ ✲ ศ 㔝⏣୰ 㤶࠾㔛㸦㸧ື ≀ ᐇ 㦂 ศ㔝ᶵ ჾ ศ ᯒ ศ㔝ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝ᢠ 㓟 ໬ ◊ ✲ 㒊 㛛㸦ඹྠ◊✲ㅮᗙ㸧⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㐠Ⴀጤဨ༊           ศ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗
㸦ጤဨ㛗㸧
ᩍ⫱Ꮫ㒊
ᆅᇦ⛉Ꮫ㒊
་Ꮫ⣔◊✲⛉࣭་Ꮫ㒊་Ꮫ㒊㝃ᒓ⑓㝔ᕤᏛ㒊ᛂ⏝⏕≀⛉Ꮫ㒊ࢤࣀ࣒◊✲ศ㔝

⛉Ꮫ◊✲
ᇶ┙ࢭࣥ
ࢱ࣮

᎘Ẽᛶ⳦◊✲ศ㔝ື≀ᐇ㦂ศ㔝
ᶵჾศᯒศ㔝
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟௧࿴  ᖺᗘ㐠Ⴀጤဨ௧࿴  ᖺᗘᩍဨ㹙௵ᮇ㹛⏣୰ 㤶࠾㔛 㸦㸧 ⏣୰ 㤶࠾㔛 㸦㸧୕Ꮿ ᓫ 㸦㸧
㹙5㹼5㹛᠕ Ụ㯯 㸦㸧
㹙5㹼5㹛ᯇᑿ ᨻஅ㸦㸧
㹙5㹼5㹛➲஭ ⱥ㞝㸦㸧
㹙5㹼5㹛኱㔝 ᩄ 㸦㸧
㹙5㹼5㹛ᒣᮏ ⩏἞㸦㸧
㹙5㹼5㹛ୗ⃝ ఙ⾜ 㸦㸧 ୗ⃝ ఙ⾜  㸦㸧
㡲㈡ ᬕஂ  㸦㸧㧗ᓥ ⱱ㞝  㸦㸧⏣୰ 㤶࠾㔛 㸦㸧 ⏣୰ 㤶࠾㔛 㸦㸧ᚋ⸨ 㝯ḟ  㸦㸧ᯘ  ᑗ኱  㸦㸧஧ୖ ⱥᶞ㸦㸧 ஧ୖ ⱥᶞ  㸦㸧ᇼ஭ ᭷ᕼ  㸦㸧ᮌෆ ୍ኖ  㸦㸧 㙊㊊ 㞝ྖ 㸦㸧≟ሯ ಇᗣ  㸦㸧

◊✲᥎㐍㒊

ㄢ㛗

ᑠᯘ ฼ᡂ 㸦㸧

◊✲஦ᴗㄢ

ㄢ㛗⿵బ

ᑠ಴ ⨾✑ 㸦㸧◊✲ᣐⅬಀ㛗
◊✲ᣐⅬಀᒾ⏣ ⱥᏕ 㸦㸧ᒸᮏ ❳ኴ 㸦㸧ᮡᒣ ⣧Ꮚ㸦㸧㸦௧࿴  ᖺ  ᭶  ᪥࠿ࡽ㸧⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤ ࣀ ࣒ ◊ ✲ ศ 㔝᎘ Ẽ ᛶ ⳦ ◊ ✲ ศ 㔝஧ୖ ⱥᶞ㸦㸧ື ≀ ᐇ 㦂 ศ㔝ᶵ ჾ ศ ᯒ ศ㔝ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝ᢠ 㓟 ໬ ◊ ✲ 㒊 㛛㸦ඹྠ◊✲ㅮᗙ㸧⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㐠Ⴀጤဨ༊           ศ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗
㸦ጤဨ㛗㸧
ᩍ⫱Ꮫ㒊
ᆅᇦ⛉Ꮫ㒊
་Ꮫ⣔◊✲⛉࣭་Ꮫ㒊་Ꮫ㒊㝃ᒓ⑓㝔ᕤᏛ㒊ᛂ⏝⏕≀⛉Ꮫ㒊ࢤࣀ࣒◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝
⛉Ꮫ◊✲
ᇶ┙ࢭࣥ
ࢱ࣮

ື≀ᐇ㦂ศ㔝
ᶵჾศᯒศ㔝
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟௧࿴  ᖺᗘ㐠Ⴀጤဨ
௧࿴ 4 ᖺᗘᩍဨ
㹙௵ᮇ㹛
஧ୖ ⱥᶞ
㸦㸧 ஧ୖ ⱥᶞ㸦㸧ⴗཎ ᏹ᫂   
㹙5㹼5㹛᠕ Ụ㯯 㸦㸧
㹙5㹼5㹛ᒣཱྀ ▐ 㸦㸧
㹙5㹼5㹛➲஭ ⱥ㞝㸦㸧
㹙5㹼5㹛኱㔝 ᩄ㸦㸧
㹙5㹼5㹛ᒣᮏ ⩏἞㸦㸧
㹙5㹼5㹛㡲㈡ ᬕஂ㸦㸧 㡲㈡ ᬕஂ  㸦㸧㧗ᓥ ⱱ㞝  㸦㸧⏣୰ 㤶࠾㔛 㸦㸧 ⏣୰ 㤶࠾㔛 㸦㸧ᚋ⸨ 㝯ḟ  㸦㸧ᯘ  ᑗ኱  㸦㸧஧ୖ ⱥᶞ㸦㸧 ஧ୖ ⱥᶞ  㸦㸧ᇼ஭ ᭷ᕼ  㸦㸧㙊㊊ 㞝ྖ 㸦㸧≟ሯ ಇᗣ  㸦㸧 ≟ሯ ಇᗣ  㸦㸧

◊✲᥎㐍㒊

ㄢ㛗

ᑠ಴ ⨾✑ 㸦㸧

◊✲ᨭ᥼ㄢ

ㄢ㛗⿵బ

໭㔝 ᩔᏊ 㸦㸧◊✲ᨭ᥼ಀ㛗◊✲ᨭ᥼ಀ஭῝ ⥤㸦㸧ᒸᮏ ❳ኴ 㸦㸧ᮡᒣ ⣧Ꮚ㸦㸧ࢭࣥࢱ࣮ἢ㠉᫛࿴  ᖺ᫛࿴  ᖺ᫛࿴  ᖺ⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊ᖹᡂ  ᖺᖹᡂ  ᖺᖹᡂ  ᖺᖹᡂඖᖺ᫛࿴  ᖺᖹᡂ  ᖺᖹᡂ  ᖺ
㑇ఏᏊᐇ㦂᪋タタ⨨㸦┬௧᪋タ㸧᫛࿴  ᖺ་Ꮫ㒊㝃ᒓ᎘Ẽᛶ⳦ᐇ㦂᪋タタ⨨㸦┬௧᪋タ㸧䠄௧࿴  ᖺ䠅ࢤࣀ࣒◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝᫛࿴  ᖺ་Ꮫ㒊㝃ᒓ᎘Ẽᛶ⳦ᐇ㦂᪋タᩚഛᖹᡂ  ᖺ
་Ꮫ㒊㝃ᒓື≀ᐇ㦂᪋タࢆᏛෆᥐ⨨ື≀ᐇ㦂ศ㔝ᖹᡂ  ᖺ
་Ꮫ㒊㝃ᒓື≀ᐇ㦂᪋タタ⨨㸦┬௧᪋タ㸧᫛࿴  ᖺ᝟ሗ࣭ィ ࢭࣥࢱ࣮ࢆᏛෆᥐ⨨ᶵჾศᯒศ㔝᫛࿴  ᖺィ ࢭࣥࢱ࣮ࢆᏛෆᥐ⨨ᖹᡂ  ᖺ
ᶵჾศᯒࢭࣥࢱ࣮タ⨨㸦┬௧᪋タ㸧᫛࿴  ᖺᨺᑕᛶྠ఩ඖ⣲ඹྠ◊✲ᐊࢆᏛෆᥐ⨨ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝ᖹᡂ  ᖺ
ᨺᑕᛶྠ఩ඖ⣲ඹྠ◊✲᪋タ࡟ᨵ⛠ᢠ㓟໬◊✲㒊㛛
㸦ඹྠ◊✲ㅮᗙ㸧ᖹᡂ  ᖺ  ᭶㹼ᖹᡂ  ᖺ࣭⏕࿨⛉Ꮫ⥲ྜᐇ㦂ࢭࣥࢱ࣮タ⨨ࢤࣀ࣒◊✲ศ㔝ࠊ᎘Ẽᛶ⳦ᐇ㦂ศ㔝ࠊື≀ᐇ㦂ศ㔝ࠊᶵჾศᯒศ㔝ࡢ  ศ㔝ࢆタ⨨࣭ᨺᑕᛶྠ఩ඖ⣲ඹྠ◊✲᪋タ࡜㑇ఏᏊᐇ㦂᪋タࢆ⤫ྜࡋࢤࣀ࣒◊✲ศ㔝࡬࣭ึ௦ࢭࣥࢱ࣮㛗࡟Ώ㑓㑥཭ᩍᤵࡀᑵ௵ᖹᡂ  ᖺ࣭⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮࡬ᨵ⛠࣭᎘Ẽᛶ⳦ᐇ㦂ศ㔝ࢆ᎘Ẽᛶ⳦◊✲ศ㔝࡬ᨵ⛠࣭ࢤࣀ࣒◊✲ศ㔝ᨺᑕᛶྠ఩ඖ⣲⟶⌮ᐊ࡟ᨵ⛠ࡋࠊᰗᡞ᪋タ࡜་Ꮫ᪋タࡢ  ᪋タ✌ാᖹᡂ  ᖺ࣭ ௦ࢭࣥࢱ࣮㛗࡟ୗ⃝ఙ⾜ᩍᤵࡀᑵ௵ᖹᡂ  ᖺ࣭ ௦ࢭࣥࢱ࣮㛗࡟Ώ㑓㑥཭ᩍᤵࡀᑵ௵ᖹᡂ  ᖺ࣭ᶵჾศᯒศ㔝་Ꮫ᪋タ✌ാᖹᡂ  ᖺ[ࢸ࢟ࢫࢺࢆධຊ]࣭ ௦ࢭࣥࢱ࣮㛗࡟ୗ⃝ఙ⾜ᩍᤵࡀᑵ௵ᖹᡂ  ᖺ࣭ᨺᑕᛶྠ఩ඖ⣲⟶⌮ᐊ࡟ᨵ⛠ࡋࠊᢸᙜࢆࢤࣀ࣒◊✲ศ㔝࠿ࡽ᎘Ẽᛶ⳦◊✲ศ㔝࡬ኚ᭦࣭ᐤ㝃◊✲㒊㛛ࠕᢠ㓟໬◊✲㒊㛛ࠖタ⨨㸦 ᖺ㛫ࠊ ᖺᘏ㛗㸧ᖹᡂ  ᖺ࣭⥲ྜ◊✲Ჷϩ᏶ᡂᖹᡂ  ᖺ࣭ᶵჾศᯒศ㔝་Ꮫ᪋タࢆᗫṆࡋࠊ୍ඖ໬ᖹᡂ  ᖺ࣭ ௦ࢭࣥࢱ࣮㛗࡟⏣୰㤶࠾㔛ᩍᤵࡀᑵ௵
࣭5, ⟶⌮ᐊ་Ꮫ᪋タࢆᗫṆࡋࠊ୍ඖ໬
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝ࢆタ⨨ᖹᡂ  ᖺ࣭◊✲᥎㐍࣭♫఍㐃ᦠᶵᵓ ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࡬ᨵ⛠ᖹᡂ  ᖺ࣭ඹྠ◊✲ㅮᗙࠕᢠ㓟໬◊✲㒊㛛ࠖ㸦 ᖺ㛫㸧௧࿴  ᖺ
࣭ᅜ❧኱Ꮫἲேᮾᾏᅜ❧኱Ꮫᶵᵓ㧗➼◊✲㝔 ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࡬ᨵ⛠௧࿴  ᖺ  ᭶࣭ྡྂᒇ኱Ꮫ࣭ᒱ㜧኱Ꮫࡀඹྠ࡛⢾㙐⏕࿨ࢥ࢔◊✲ᡤタ⨨ ᖺᗘάື≧ἣሗ࿌➨  ᅇ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟㸦㸧⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮බ㛤ㅮᗙ㸦 ᭶௧࿴  ᖺ  ᭶  ᪥㸦Ỉ㸧 ᪥㛤ദ㸧࡟ࡘ࠸࡚㆟㢟㸦㸧ᒱ㜧኱Ꮫࢿࢵࢺ࣮࣡ࢡᆺඹ⏝ᶵჾ࡟ಀ➨  ᅇ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟ࡿ⏦ྜࡏ࡟ࡘ࠸࡚
㸦㸧වᴗ࡟ࡘ࠸࡚௧࿴  ᖺ  ᭶  ᪥㸦ᮌ㸧㸦㸧බ㛤ㅮᗙ࡟ࡘ࠸࡚

㆟㢟㸦㸧ᒱ㜧኱Ꮫࢿࢵࢺ࣮࣡ࢡᆺඹ⏝ᶵჾ࡟ಀࡿ⏦ྜࡏࡢᗫṆ࡟ࡘ࠸࡚➨  ᅇ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟㸦㸧ᒱ㜧኱Ꮫࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃௧࿴  ᖺ  ᭶  ᪥㸦Ỉ㸧ᦠᐊ࡟ಀࡿ⏦ྜࡏࡢไᐃ࡟ࡘ࠸࡚

㆟㢟㸦㸧වᴗ࡟ࡘ࠸࡚

㸦㸧ᒱ㜧኱Ꮫࢿࢵࢺ࣮࣡ࢡᆺඹ⏝ᶵჾࡢᗫṆ࡜ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ㸦㸧ࢤࣀ࣒◊✲ศ㔝ཷクヨ㦂㸪 ᐃཬࡧ᳨ࡢ᪂タ࡟ࡘ࠸࡚

ᰝ➼ྲྀᢅせ㡯ࡢไᐃ࡟ࡘ࠸࡚

➨  ᅇ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟➨  ᅇ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟௧࿴  ᖺ  ᭶  ᪥㸦ᮌ㸧௧࿴  ᖺ  ᭶  ᪥㸦ᮌ㸧㆟㢟㸦㸧≉ู༠ຊ◊✲ဨ࡟ࡘ࠸࡚

㆟㢟㸦㸧≉ู༠ຊ◊✲ဨࡢ⏦ㄳ࡟ࡘ࠸࡚
㸦㸧௧࿴  ᖺᗘබ㛤ㅮᗙᐇ᪋ィ⏬᭩࡟ࡘ࠸㸦㸧⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㐠Ⴀጤဨ఍ࡢ㛤
ദ࡟ࡘ࠸࡚

࡚



㸦㸧➨  ᮇ  ᖺࡢࢭࣥࢱ࣮άືィ⏬࡟ࡘ࠸㸦㸧වᴗ࡟ࡘ࠸࡚
㸦㸧බ㛤ㅮᗙ࡟ࡘ࠸࡚

࡚㸦㸧ື≀៘㟋⚍࡟ࡘ࠸࡚ ୰Ṇ➨  ᅇ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟➨  ᅇ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟௧࿴  ᖺ  ᭶  ᪥㸦ᮌ㸧௧࿴  ᖺ  ᭶  ᪥㸦ᮌ㸧㆟㢟㸦㸧≉ู༠ຊ◊✲ဨࡢཷධࢀ࡟ࡘ࠸࡚
㸦㸧௧࿴  ᖺᗘࢭࣥࢱ࣮ෆࡢᢸᙜ࣮ࣟࢸ࣮

㆟㢟㸦㸧≉ู༠ຊ◊✲ဨ࡟ࡘ࠸࡚

ࢩࣙࣥ࡟ࡘ࠸࡚

㸦㸧⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㐠Ⴀጤဨ఍࡟ࡘ

㸦㸧ྛ✀ጤဨ఍࡟ࡘ࠸࡚

࠸࡚㸦㸧➨  ᮇ୰ᮇ┠ᶆࠊ୰ᮇィ⏬࡟࠿࠿ࡿ࢔
ࢡࢩࣙࣥࣉࣛࣥ࡟ࡘ࠸࡚

➨  ᅇ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟௧࿴  ᖺ  ᭶  ᪥㸦ᮌ㸧㆟㢟㸦㸧㈉⊩ᗘᐇ⦼࣭⮬ᕫホ౯࡟ࡘ࠸࡚
㸦㸧ࢿࢵࢺ࣮࣡ࢡᆺඹ⏝ᨭ᥼ᐊ࡟ࡘ࠸࡚

ᖺᗘᨭ᥼≧ἣ

2021ᖺᗘⓏ㘓䜾䝹䞊䝥ᩘ䝀䝜䝮◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝ື≀ᐇ㦂ศ㔝
ᶵჾศᯒศ㔝
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝

ᩍ⫱ ᆅᇦ
4
1
0
0
1
0
5
0
6
0

ϭϬϬ
་䞉⑓
㝔

23
1
44
3
1

ᕤ
11
1
1
36
12

ᶵჾศᯒศ㔝ᛂ⏝⏕ 䛭䛾௚
Ꮫእ
≀
*

48
0
21
20
7

28
6
10
18
4

ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝

ϴϬ

5
2
12
0
0

ື≀ᐇ㦂ศ㔝
᎘Ẽᛶ⳦◊✲ศ㔝䝀䝜䝮◊✲ศ㔝ϲϬ䠆䛭䛾௚䠖ὶᇦ䚸⛉ᇶ䝉䚸⢾㙐䚸㐃㎰䚸㐃๰䚸㧗➼◊䚸⸆኱䚸ྡ኱䛺䛹

ϰϬ

ϮϬ

Ϭ
ᩍ⫱

ᆅᇦ

་䞉⑓㝔

ᛂ⏝⏕≀ 䛭䛾௚ΎᕤᏛእᖺᗘⓏ㘓ࢢ࣮ࣝࣉᩘ
2021ᖺᗘⓏ㘓⪅ᩘ䝀䝜䝮◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝ື≀ᐇ㦂ศ㔝
ᶵჾศᯒศ㔝
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝

ϯϰϬϬ

ᩍ⫱ ᆅᇦ
14
4
0
0
2
0
94
0
25
0

་䞉⑓
㝔

115
2
388
66
8

ᕤ
92
3
15
3173
86

ᛂ⏝⏕ 䛭䛾௚
Ꮫእ
≀
*

339
0
80
641
38

193
12
35
457
5

ϭϮϬϬ

5
4
156
0
3

ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝
ϭϬϬϬ
ϴϬϬ

䠆䛭䛾௚䠖ὶᇦ䚸⛉ᇶ䝉䚸⢾㙐䚸㐃㎰䚸㐃๰䚸㧗➼◊䚸⸆኱䚸ྡ኱䛺䛹ϲϬϬᶵჾศᯒศ㔝
ື≀ᐇ㦂ศ㔝
᎘Ẽᛶ⳦◊✲ศ㔝䝀䝜䝮◊✲ศ㔝ϰϬϬϮϬϬ䝉䞁䝍䞊䜢฼⏝䛧䛶Ⓨ⾲䛥䜜䛯ㄽᩥ䠄◊✲ᨭ᥼ㄽᩥ䠅ᩘ᥎⛣

Ϭ

ᩍ⫱

ᆅᇦ

་䞉⑓㝔

ᕤ

ᛂ⏝⏕≀

䚷ᖺ䚷ᗘ
2006 2007 2008 2009 2010 2011 2012
2013
2015
2016
ᖺᗘⓏ㘓⪅ᩘ38
73 103
63
53
0
5
5
4
1
59
58
63
73
42
ϲϬϬ
62
60
56
76
63
51
65
65
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝
12
17
11
15
17
4

䝀䝜䝮◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝ື≀ᐇ㦂ศ㔝
ᶵჾศᯒศ㔝
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝

2004 2005
69
69
29
2
0
33
52
80
12
10

䝀䝜䝮◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝ື≀ᐇ㦂ศ㔝
ᶵჾศᯒศ㔝
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝

2010 2011 2012 2013 2014 2015
53
73
95
97 134 103
1
3
1
2
0
2
42
50
66
68
39
62
63
70
51
65
65
53
17
11
13
4
4
3

䝀䝜䝮◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝ື≀ᐇ㦂ศ㔝
ᶵჾศᯒศ㔝
ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝

2016 2017 2018 2019 2020 2021
253 273 275 294 366 322
5
3
2
3
2
7
53
82
56
50
44
38
54
48
66
91
63
84
4
2
4
7
10
1

䛭䛾௚Ύ

Ꮫእ

ᶵჾศᯒศ㔝

ϱϬϬື≀ᐇ㦂ศ㔝

ϰϬϬ᎘Ẽᛶ⳦◊✲ศ㔝䝀䝜䝮◊✲ศ㔝

ϯϬϬ
ϮϬϬ
ϭϬϬ
Ϭ

ϮϬϬϰ ϮϬϬϱ ϮϬϬϲ ϮϬϬϳ ϮϬϬϴ ϮϬϬϵ ϮϬϭϬ ϮϬϭϭ ϮϬϭϮ ϮϬϭϯ ϮϬϭϰ ϮϬϭϱ ϮϬϭϲ ϮϬϭϳ ϮϬϭϴ ϮϬϭϵ ϮϬϮϬ ϮϬϮϭ◊✲ᨭ᥼ㄽᩥᩘ᥎⛣ ᖺᗘᒱ㜧኱Ꮫබ㛤ㅮᗙᒱ㜧኱Ꮫ㧗➼◊✲㝔つ⛬௧࿴  ᖺ  ᭶  ᪥ᒱ኱つ⛬➨  ྕᨵ ṇ ௧ ࿴  ᖺ  ᭶  ᪥ ᒱ኱ つ ⛬ ➨  ྕ ௧ ࿴  ᖺ  ᭶   ᪥ ᒱ ኱つ ⛬ ➨   ྕ㊃᪨➨᮲ࡇࡢつ⛬ࡣ㸪ᒱ㜧኱Ꮫ⤌⧊㐠Ⴀつ⛬㸦௧࿴  ᖺᗘᒱ኱つ⛬➨  ྕ㸧➨  ᮲࡟つᐃࡍࡿ㧗➼◊✲㝔㸦௨ୗࠕ◊✲㝔ࠖ࡜࠸࠺ࠋ㸧࡟㛵ࡋᚲせ࡞஦㡯ࢆᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ
┠ⓗ
➨  ᮲

◊✲㝔ࡣ㸪◊✲࡟ᑓᛕࡍࡿ⤌⧊࡜ࡋ࡚㸪ᮾᾏᅜ❧኱Ꮫᶵᵓࡢ≉Ⰽཬࡧᙉࡳࢆά࠿ࡋࡓ

࢖ࣀ࣮࣋ࢩࣙࣥࡢ※Ἠ࡜࡞ࡾᚓࡿ᭱ඛ➃ࡢ◊✲ࢆᒎ㛤ࡍࡿࡇ࡜࡟ࡼࡾ㸪Ꮫ⾡ࡢⓎᒎཬࡧ㧗ᗘேᮦࡢ⫱ᡂࢆᅗࡿ࡜࡜ࡶ࡟㸪ࡑࡢᡂᯝࢆ♫఍࡟㑏ඖࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ⫋ဨ➨᮲◊✲㝔࡟㸪㧗➼◊✲㝔㛗㸦௨ୗࠕ◊✲㝔㛗ࠖ࡜࠸࠺ࠋ㸧ࡢ࡯࠿㸪ḟࡢ⫋ဨࢆ⨨ࡃࠋ

୍

๪◊✲㝔㛗

஧

ᑓ௵ࡢ኱Ꮫᩍဨ

୕ව௵ࡢ኱Ꮫᩍဨ

ᅄࡑࡢ௚ࡢ⫋ဨ

๪◊✲㝔㛗
➨᮲


๪◊✲㝔㛗ࡣ㸪◊✲㝔࡟ᡤᒓࡍࡿ኱Ꮫᩍဨࡢ࠺ࡕ࠿ࡽ㸪◊✲㝔㛗ࡀᣦྡࡍࡿࠋ

๪◊✲㝔㛗ࡢ௵ᮇࡣ㸪 ᖺ࡜ࡋ㸪෌௵ࢆጉࡆ࡞࠸ࠋࡓࡔࡋ㸪ᣦྡࡍࡿ◊✲㝔㛗ࡢ௵ᮇࡢ⠊ᅖ
ෆ࡜ࡍࡿࠋ
㢳ၥ

➨᮲


◊✲㝔࡟㸪㢳ၥࢆ⨨ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ㢳 ၥ ࡣ 㸪◊ ✲ 㝔ࡢ ㅖ άື ࡟ 㛵 ࡍࡿ ஦ 㡯࡟ ࡘ ࠸࡚ 㸪 ◊ ✲㝔 㛗 ࡢㅎ ၥ ࡟ᛂ ࡌ ࡚ ពぢ ࢆ ㏙࡭ 㸪 ཪࡣຓゝࢆ⾜࠺ࠋ

㢳ၥࡣ㸪◊✲㝔ࡢㅖάື࡟ᚲせ࡞Ꮫ㆑⤒㦂ࢆ᭷ࡍࡿ⪅࡟ጤკࡍࡿࠋ

㢳ၥࡢ௵ᮇࡣ㸪ࡑࡢ௵ົࡢ㐙⾜࡟ᚲせ࡜ࡍࡿᮇ㛫࡜ࡍࡿࠋ
㐠Ⴀጤဨ఍

➨  ᮲

◊✲㝔࡟㸪◊✲㝔ࡢ㐠Ⴀ࡟㛵ࡍࡿ஦㡯ࢆᑂ㆟ࡍࡿࡓࡵ㸪㐠Ⴀጤဨ఍㸦௨ୗࠕጤဨ఍ࠖ

࡜࠸࠺ࠋ㸧ࢆ⨨ࡃࠋጤဨ఍ࡢ⤌⧊ཬࡧ㐠Ⴀ࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ጤဨ఍ࡢ㆟ࢆ⤒࡚㸪◊✲㝔㛗ࡀᐃࡵࡿࠋ
ᣐⅬ໬ᐇ⾜⤌⧊➨᮲◊✲㝔࡟ᮾᾏᅜ❧኱Ꮫᶵᵓᶵᵓᩍ⫱◊✲᥎㐍➼⤌⧊つ⛬㸦௧࿴  ᖺᗘᶵᵓつ⛬➨  ྕ㸧➨  ᮲➨  㡯➨  ྕ࡟つᐃࡍࡿᣐⅬࡢ▱ࡢᣐⅬ໬ࢆᐇ⾜ࡍࡿ⤌⧊࡜ࡋ࡚㸪⯟✵Ᏹᐂ⏕⏘ᢏ⾡
㛤Ⓨࢭࣥࢱ࣮ࢆ⨨ࡃࠋ๓㡯࡟つᐃࡍࡿࢭࣥࢱ࣮࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ู࡟ᐃࡵࡿࠋ
ࢭࣥࢱ࣮

➨᮲


◊✲㝔࡟◊✲ࢆᐇ᪋ཪࡣᨭ᥼ࡍࡿࢭࣥࢱ࣮ࢆ⨨ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ๓㡯࡟つᐃࡍࡿࢭࣥࢱ࣮࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ู࡟ᐃࡵࡿࠋ

ᑓ௵ࡢ኱Ꮫᩍဨ➨᮲➨  ᮲➨  ྕ࡟つᐃࡍࡿᑓ௵ࡢ኱Ꮫᩍဨࡢ㑅⪃࡟ࡘ࠸࡚ࡣ㸪ู࡟ᐃࡵࡿࠋ

ව௵ࡢ኱Ꮫᩍဨ
➨  ᮲➨  ᮲➨  ྕ࡟つᐃࡍࡿව௵ࡢ኱Ꮫᩍဨ࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ู࡟ᐃࡵࡿࠋ

≉ูᣍ⪸◊✲ဨ➨  ᮲

Ꮫ㛗ࡣ㸪ᅜ㝿ⓗ࡟ᴟࡵ࡚㢧ⴭ࡞ຌ⦼➼ࡀㄆࡵࡽࢀ㸪◊✲㝔ࡢⓎᒎ࡟㈉⊩ࡍࡿ࡜ㄆࡵࡽ

ࢀࡿ⪅ࢆ㸪≉ูᣍ⪸◊✲ဨ࡜ࡋ࡚ཷࡅධࢀࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
≉ูᣍ⪸◊✲ဨ࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪◊✲㝔㛗ࡀᐃࡵࡿࠋ
◊✲⛉࡬ࡢ༠ຊ

➨  ᮲

◊✲㝔ࡣ㸪◊✲⛉࡜༠㆟ࡢ࠺࠼㸪ࡑࡢᩍ⫱࡟༠ຊࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

ᐤ㝃◊✲㒊㛛➼➨  ᮲

◊✲㝔࡟ᐤ㝃◊✲㒊㛛㸪ඹྠ◊✲ㅮᗙཪࡣඹྠ◊✲㒊㛛ࢆ⨨ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ஦ົ➨  ᮲

◊✲㝔ࡢ஦ົࡣ㸪㛵ಀ㒊࣭ㄢࡢ༠ຊࢆᚓ࡚㸪◊✲᥎㐍㒊◊✲ᨭ᥼ㄢ࡟࠾࠸࡚ฎ⌮ࡍࡿࠋ㞧๎➨  ᮲㝃ࡇࡢつ⛬࡟ᐃࡵࡿࡶࡢࡢ࡯࠿㸪◊✲㝔࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪◊✲㝔㛗ࡀู࡟ᐃࡵࡿࠋ๎ࡇࡢつ⛬ࡣ㸪௧࿴  ᖺ  ᭶  ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ ௧࿴  ᖺ  ᭶  ᪥ᒱ኱つ⛬➨  ྕࡇࡢつ⛬ࡣ㸪௧࿴  ᖺ  ᭶  ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ ௧࿴  ᖺ  ᭶  ᪥ᒱ኱つ⛬➨  ྕࡇࡢつ⛬ࡣ㸪௧࿴  ᖺ  ᭶  ᪥࠿ࡽ᪋⾜ࡍࡿࠋᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮⣽๎ᖹᡂ  ᖺ  ᭶  ᪥⣽๎➨  ྕᨵ ṇ ௧ ࿴  ᖺ  ᭶  ᪥ ᒱ኱ ⣽ ๎ ➨  ྕ௧ ࿴  ᖺ  ᭶   ᪥ ᒱ ኱⣽ ๎ ➨   ྕ௧ ࿴  ᖺ   ᭶   ᪥ᒱ ኱ ⣽๎ ➨   ྕ

㊃᪨
➨  ᮲

ࡇࡢ⣽๎ࡣ㸪ᒱ㜧኱Ꮫ㧗➼◊✲㝔つ⛬㸦௧࿴  ᖺᗘᒱ኱つ⛬➨  ྕ㸧➨  ᮲➨  㡯ࡢつ ᐃ࡟ ᇶ࡙ ࡁ 㸪⛉ Ꮫ ◊✲ ᇶ┙ ࢭࣥ ࢱ࣮ ௨ୗ ࠕࢭ ࣥࢱ ࣮ࠖ ࡜࠸ ࠺ ࠋ ࡟㛵 ࡋᚲ せ࡞ ஦㡯 ࢆᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ┠ⓗ➨  ᮲ࢭࣥࢱ࣮ࡣ㸪ᒱ㜧኱Ꮫ ௨ୗࠕᮏᏛࠖ࡜࠸࠺ࠋ ࡢඹྠᩍ⫱◊✲ᇶ┙᪋タ࡜ࡋ࡚㸪⏕࿨ ⛉Ꮫ ࡟ 㛵 㐃 ࡍࡿ ඛ 㐍 ⓗ ศ㔝 ࡢ ᩍ ⫱ ◊✲ ࢆ ⾜ ࠺ ࡜࡜ ࡶ ࡟ ᨺ ᑕᛶ ྠ ఩ ඖ ⣲㸪 ᐇ 㦂 ື ≀㸪 ኱ ᆺศ ᯒᶵ ჾ ➼ ࡢ 㐺ษ ࡞ ⟶ ⌮ ࢆ⾜ ࠺ ࡇ ࡜ ࡟ࡼ ࡾ 㸪 ᮏ Ꮫ࡟ ࠾ ࡅ ࡿ ⏕࿨ ⛉ Ꮫ ศ 㔝ࡢ ᩍ ⫱ ◊ ✲ࡢ ⥲ ྜⓗ᥎㐍ࢆᅗࡿࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ⤌⧊➨᮲ࢭࣥࢱ࣮࡟ḟࡢศ㔝ࢆ⨨ࡁ㸪ྛศ㔝ࡢᴗົࡣ㸪ḟࡢ࡜࠾ࡾ࡜ࡍࡿࠋ
ศ㔝ࢤࣀ࣒◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝ᴗ  ົ
୍ࢤࣀ࣒ゎᯒࢆ୰ᚰ࡜ࡋࡓ⏕࿨⛉Ꮫศ㔝࡟࠾ࡅࡿ◊✲஧୕⏕యศᏊゎᯒ➼ࡢ◊✲ᇶ┙ᩚഛཬࡧ◊✲ᨭ᥼ࡑࡢ௚⏕࿨⛉Ꮫ◊✲࡟㛵ࡍࡿࡇ࡜ࠋ୍ ᎘Ẽᛶ⳦ឤᰁ⑕ཬࡧ᎘Ẽᛶ⳦⑕ࡢデ᩿㸪⑓ᅉ㸪἞⒪㸪ண㜵➼  ࡟㛵ࡍࡿᇶ♏ⓗ࣭⮫ᗋ⣽⳦Ꮫⓗ◊✲஧೫ᛶ᎘Ẽᛶ⳦ࢆ୰ᚰ࡜ࡋࡓᚤ⏕≀㑇ఏ㈨※ࡢ⣔⤫ಖᏑ୕ ᎘Ẽᛶ⳦ឤᰁ⑕ࡢデ᩿ᨭ᥼㸪᎘Ẽᛶ⳦ࡢᇵ㣴࣭ศ㞳࣭ྠᐃ㸪  ᎘Ẽᛶ⳦ࢆ⏝࠸ࡓ◊✲࡟㛵ࡍࡿᨭ᥼ື≀ᐇ㦂ศ㔝

ᶵჾศᯒศ㔝

ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝ᅄ୍ࡑࡢ௚᎘Ẽᛶ⳦ᐇ㦂࡟㛵ࡍࡿࡇ࡜ࠋ
ື≀ᐇ㦂ࣔࢹࣝཬࡧᐇ㦂⏝ື≀ࡢ㛤Ⓨ◊✲㸪㑇ఏ㈨※⟶⌮஧ᐇ㦂ື≀ࡢ㣫⫱⟶⌮ཬࡧᐇ㦂ື≀ࢆ⏝࠸ࡓᩍ⫱◊✲ࡢᨭ᥼

୕
୍
஧
୕
ᅄ

ࡑࡢ௚ື≀ᐇ㦂࡟㛵ࡍࡿࡇ࡜ࠋ
ࢼࣀࢫࢣ࣮ࣝ࡟࠾ࡅࡿ᪂つศᯒᢏ⾡ࡢ㛤Ⓨ◊✲⏕యヨᩱཬࡧᶵ⬟ᛶ໬ྜ≀ࡢศᏊᵓ㐀ゎᯒ࡟㛵ࡍࡿ◊✲ᨭ᥼ศᯒᶵჾࡢ⥔ᣢ⟶⌮ཬࡧศᯒᢏ⾡ࡢᣦᑟࡑࡢ௚ᶵჾศᯒ࡟㛵ࡍࡿࡇ࡜ࠋ୍ ᨺᑕᛶྠ఩ඖ⣲ࡢ⟶⌮ཬࡧᨺᑕᛶྠ఩ඖ⣲ࢆ⏝࠸ࡓᩍ⫱◊✲  ࡢᨭ᥼஧ ⮬↛ᨺᑕ⥺㸪⎔ቃᨺᑕ⥺࡟㛵ࡍࡿᩍ⫱◊✲ࡢᨭ᥼୕ࡑࡢ௚ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂࡟㛵ࡍࡿࡇ࡜ࠋ  ࢭࣥࢱ࣮࡟◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊࢆ⨨ࡁ㸪Ꮫෆእ࡬ࡢཷクゎᯒࢆ㛤Ⓨࡋ㸪ඹྠ฼⏝ࢆ᥎㐍ࡍࡿࠋࢤࣀ࣒◊✲ศ㔝࡟㧗➼◊✲㝔㑇ఏᏊ᳨ᰝᐊࢆ⨨ࡁ㸪Ꮫෆ◊✲ᡂᯝࡢ♫఍ᐇ⿦ࢆ᥎㐍ࡍࡿࠋᶵჾศᯒศ㔝࡟ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊࢆ⨨ࡁ㸪ࢭࣥࢱ࣮ࡀ⟶⌮ࡍࡿࢥ࢔ࣇ࢓ࢩ
ࣜࢸ࢕Ⓩ㘓ඹ⏝ᶵჾࡢ฼⏝ࢆ᥎㐍ࡍࡿࠋ⫋ဨ➨᮲ࢭࣥࢱ࣮࡟ḟࡢ⫋ဨࢆ⨨ࡃࠋ

୍

ࢭࣥࢱ࣮㛗

஧

ᖖ໅ࡢ኱Ꮫᩍဨ

୕ࡑࡢ௚ࡢ⫋ဨ

ࢭࣥࢱ࣮㛗
➨᮲


ࢭࣥࢱ࣮㛗ࡣ㸪ࢭࣥࢱ࣮ࡢᴗົࢆᤸ⌮ࡍࡿࠋࢭࣥࢱ࣮㛗ࡣ㸪㧗➼◊✲㝔㛗ࡢ᥎⸀࡟ᇶ࡙ࡁ㸪Ꮫ㛗ࡀ㑅⪃ࡍࡿࠋᖖ໅ࡢ኱Ꮫᩍဨࡢ㑅⪃➨᮲➨  ᮲➨  ྕ࡟つᐃࡍࡿᖖ໅ࡢ኱Ꮫᩍဨࡢ㑅⪃࡟ࡘ࠸࡚ࡣ㸪ู࡟ᐃࡵࡿࠋ

ศ㔝㛗
➨᮲


ྛศ㔝࡟ศ㔝㛗ࢆ⨨ࡁ㸪ᙜヱศ㔝ࡢᖖ໅ࡢᩍᤵ㸪෸ᩍᤵཪࡣㅮᖌࢆࡶࡗ࡚඘࡚ࡿࠋ

ศ㔝㛗ࡣ㸪ࢭࣥࢱ࣮㛗ࡢ࿨ࢆཷࡅ㸪ᙜヱศ㔝࡟࠾ࡅࡿᴗົࢆ⥲ᣓཬࡧᩚ⌮ࡍࡿࠋ
ᐊ㛗

➨᮲


ྛᐊ࡟ᐊ㛗ࢆ⨨ࡁ㸪ࢭࣥࢱ࣮ࡢᖖ໅ᩍဨࢆࡶࡗ࡚඘࡚ࡿࠋ

ྛᐊ㛗ࡣ㸪ࢭࣥࢱ࣮㛗ࡢ࿨ࢆཷࡅ㸪ྛᐊ࡟࠾ࡅࡿᴗົࢆ⥲ᣓཬࡧᩚ⌮ࡍࡿࠋᨺᑕ⥺ྲྀᢅ᪋タ⟶⌮㈐௵⪅➨  ᮲ᨺᑕ⥺ྲྀᢅ᪋タ࡟ᒱ㜧኱Ꮫᨺᑕ⥺㞀ᐖ㜵Ṇ⟶⌮つ⛬㸦ᖹᡂ  ᖺつ⛬➨  ྕ㸧➨ ᮲࡟つᐃࡍࡿ⟶⌮㈐௵⪅ࢆ⨨ࡁ㸪ࢭࣥࢱ࣮ࡢᖖ໅ࡢ኱Ꮫᩍဨ㸦ᑓ௵㸧ࢆࡶࡗ࡚඘࡚ࡿࠋ
ᩍဨ఍㆟➨  ᮲

ࢭࣥࢱ࣮࡟㸪⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟ ௨ୗࠕࢭࣥࢱ࣮ᩍဨ఍㆟ࠖ࡜࠸࠺ࠋ

ࢆ⨨ࡃࠋࢭࣥࢱ࣮ᩍဨ఍㆟࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ู࡟ᐃࡵࡿࠋ
㐠Ⴀጤဨ఍➨  ᮲

ࢭࣥࢱ࣮࡟㸪ࢭࣥࢱ࣮ࡢඹྠ฼⏝࡟㛵ࡍࡿ஦㡯㸪ࢭࣥࢱ࣮㛗 ࠿ࡽㅎၥࡉࢀࡓ஦㡯➼ࢆ༠ ㆟ࡍ ࡿࡓ ࡵ㸪 ⛉Ꮫ ◊✲ ᇶ┙ ࢭࣥ ࢱ࣮ 㐠Ⴀ ጤဨ ఍ ௨ୗ ࠕ㐠 Ⴀጤ ဨ ఍ࠖ ࡜࠸ ࠺ࠋ ࢆ ⨨ࡃ ࠋ㐠Ⴀጤဨ఍࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ู࡟ᐃࡵࡿࠋ
ᶵჾศᯒศ㔝༠ຊဨ➨  ᮲

ᶵჾศᯒศ㔝࡟㸪ᙜヱศ㔝ࡢᴗົ࡟༠ຊࡋ㸪฼⏝ཬࡧศᯒᢏ⾡ࡢ◊✲㸪㛤Ⓨ➼ࢆ⾜࠺ࡓࡵ㸪ᶵჾศᯒศ㔝༠ຊဨࢆ⨨ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ
ᶵჾศᯒศ㔝༠ຊဨࡣ㸪ᮏᏛࡢᑓ௵ࡢ኱Ꮫᩍဨࢆࡶࡗ࡚඘࡚ࡿࠋ๓㡯࡟つᐃࡍࡿࡶࡢࡢ࡯࠿㸪ᶵჾศᯒศ㔝༠ຊဨ࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ู࡟ᐃࡵࡿࠋᗢົ➨  ᮲

ࢭࣥࢱ࣮࡟㛵ࡍࡿᗢົࡣ㸪◊✲᥎㐍㒊◊✲஦ᴗㄢ࡟࠾࠸࡚ฎ⌮ࡍࡿࠋ㞧๎➨  ᮲

ࡇࡢ⣽๎࡟ᐃࡵࡿࡶࡢࡢ࡯࠿㸪ࢭࣥࢱ࣮࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ࢭࣥࢱ࣮ᩍဨ఍㆟ࡢពぢࢆ⫈࠸࡚㸪㧗➼◊✲㝔㛗ࡀᐃࡵࡿࠋ



㝃

๎



ࡇࡢ⣽๎ࡣ㸪ᖹᡂ  ᖺ  ᭶  ᪥࠿ࡽ᪋⾜ࡍࡿࠋᒱ㜧኱Ꮫ⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮つ⛬ ᖹᡂ  ᖺつ⛬➨  ྕ ࡣ㸪ᗫṆࡍࡿࠋ㝃๎ ௧࿴  ᖺ  ᭶  ᪥ᒱ኱⣽๎➨  ྕࡇࡢ⣽๎ࡣ㸪௧࿴  ᖺ  ᭶  ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ ௧࿴  ᖺ  ᭶  ᪥ᒱ኱⣽๎➨  ྕࡇࡢ⣽๎ࡣ㸪௧࿴  ᖺ  ᭶  ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ ௧࿴  ᖺ  ᭶  ᪥ᒱ኱⣽๎➨  ྕࡇࡢ⣽๎ࡣ㸪௧࿴  ᖺ  ᭶  ᪥࠿ࡽ᪋⾜ࡍࡿࠋᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㐠Ⴀጤဨ఍せ㡯   ᖹᡂ㸱㸮ᖺ㸲᭶㸯᪥    ไᐃ㸦㊃᪨㸧➨㸯᮲ ࡇࡢせ㡯ࡣ㸪ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮⣽๎➨㸯㸮᮲➨㸰㡯ࡢつᐃ࡟ᇶ࡙ࡁ㸪⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㸦௨ୗࠕࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ㸧࡟⨨ࡃ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㐠Ⴀጤဨ఍㸦௨ୗࠕጤဨ఍ࠖ࡜࠸࠺ࠋ㸧࡟㛵ࡋᚲせ࡞஦㡯ࢆᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ
㸦ᑂ㆟஦㡯㸧➨㸰᮲ ጤဨ఍ࡣ㸪ࢭࣥࢱ࣮࡟㛵ࡍࡿḟࡢྛྕ࡟ᥖࡆࡿ஦㡯ࢆᑂ㆟ࡍࡿࠋ୍ ඹྠ฼⏝࡟㛵ࡍࡿࡇ࡜ࠋ஧ ᐇ㦂᪋タ➼ࡢ฼⏝࡟ಀࡿᏳ඲⟶⌮࡟㛵ࡍࡿࡇ࡜ࠋ୕ ࢭࣥࢱ࣮㛗࠿ࡽㅎၥࡉࢀࡓ஦㡯ᅄ ࡑࡢ௚ጤဨ఍ࡀᚲせ࡜ㄆࡵࡿ஦㡯㸦⤌⧊㸧➨㸱᮲ ጤဨ఍ࡣ㸪ḟࡢྛྕ࡟ᥖࡆࡿጤဨࢆࡶࡗ࡚⤌⧊ࡍࡿࠋ୍ ࢭࣥࢱ࣮㛗஧ ࢭࣥࢱ࣮ࡢྛศ㔝ࡢ㛗ཬࡧᨺᑕ⥺ྲྀᢅ᪋タ⟶⌮㈐௵⪅୕ ྛᏛ㒊㸦་Ꮫ㒊ࢆ㝖ࡃࠋ㸧࠿ࡽ㑅ฟࡉࢀࡓᩍ⫱⫋ဨྛ㸯ேᅄ ་Ꮫ⣔◊✲⛉࣭་Ꮫ㒊࠿ࡽ㑅ฟࡉࢀࡓᩍ⫱⫋ဨ஬ ་Ꮫ㒊㝃ᒓ⑓㝔࠿ࡽ㑅ฟࡉࢀࡓᩍ⫱⫋ဨ㸯ே㸯ேභ ࡑࡢ௚ጤဨ఍ࡀᚲせ࡜ㄆࡵࡿ⪅㸰 ๓㡯➨㸴ྕ࡟つᐃࡍࡿጤဨ࡟ࡣ㸪እ㒊᭷㆑⪅ࢆྵࡵࡿࡇ࡜ࡀ࡛ࡁࡿࠋ㸱 ➨㸯㡯➨㸱ྕ࠿ࡽ➨㸴ྕࡲ࡛࡟つᐃࡍࡿጤဨࡣ㸪ࢭࣥࢱ࣮㛗ࡀጤკࡍࡿࠋ㸦௵ᮇ㸧➨㸲᮲ ๓᮲➨㸯㡯➨㸱ྕ࠿ࡽ➨㸴ྕࡲ࡛࡟つᐃࡍࡿጤဨࡢ௵ᮇࡣ㸪㸰ᖺ࡜ࡋ㸪෌௵ࢆጉࡆ࡞࠸ࠋࡓ
ࡔࡋ㸪ጤဨ࡟Ḟဨࡀ⏕ࡌࡓ࡜ࡁࡢ⿵Ḟጤဨࡢ௵ᮇࡣ㸪๓௵⪅ࡢṧ௵ᮇ㛫࡜ࡍࡿࠋ㸦ጤဨ㛗㸧➨㸳᮲ ጤဨ఍࡟ጤဨ㛗ࢆ⨨ࡃࠋ㸰 ጤဨ㛗ࡣ㸪ࢭࣥࢱ࣮㛗ࢆࡶࡗ࡚඘࡚ࡿࠋ㸱 ጤဨ㛗ࡣ㸪ጤဨ఍ࢆᣍ㞟ࡋ㸪ࡑࡢ㆟㛗࡜࡞ࡿࠋ㸲ጤဨ㛗࡟஦ᨾࡀ࠶ࡿ࡜ࡁࡣ㸪ጤဨ㛗ࡀ࠶ࡽ࠿ࡌࡵᣦྡࡍࡿጤဨࡀࡑࡢ⫋ົࢆ௦⌮ࡍࡿࠋ㸦఍㆟㸧➨㸴᮲ ጤဨ఍ࡣ㸪ጤဨࡢ㸱ศࡢ㸰௨ୖࡢฟᖍࢆࡶࡗ࡚ᡂ❧ࡍࡿࠋ㸰㆟஦ࡣ㸪ฟᖍጤဨࡢ㐣༙ᩘࡢྠពࢆࡶࡗ࡚Ỵࡋ㸪ྍྰྠᩘࡢ࡜ࡁࡣ㸪㆟㛗ࡢỴࡍࡿ࡜ࡇࢁ࡟ࡼࡿࠋ
㸦ጤဨ௨እࡢ⪅ࡢฟᖍ㸧➨㸵᮲ ጤဨ఍ࡀᚲせ࡜ㄆࡵࡿ࡜ࡁࡣ㸪ጤဨ௨እࡢ⪅ࡢฟᖍࢆồࡵ࡚㸪ࡑࡢពぢࢆ⫈ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ
㸦ᑓ㛛㒊఍㸧➨㸶᮲ ጤဨ఍ࡣ㸪ᚲせ࡟ᛂࡌ㸪≉ᐃࡢ஦㡯ࢆᑂ㆟ࡍࡿࡓࡵ㸪ᑓ㛛㒊఍ࢆ⨨ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ㸰 ᑓ㛛㒊఍࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ู࡟ᐃࡵࡿࠋ



㸦㆟Ỵ㸧
➨㸷᮲

ጤဨ఍ࡣ㸪ࡑࡢᐃࡵࡿ࡜ࡇࢁ࡟ࡼࡾ㸪ᑓ㛛㒊఍ࡢ㆟Ỵࢆࡶࡗ࡚ጤဨ఍ࡢ㆟Ỵ࡜ࡍࡿࡇ࡜ࡀ࡛

ࡁࡿࠋ
㸦㞧๎㸧
➨㸯㸮᮲

ࡇࡢせ㡯࡟ᐃࡵࡿࡶࡢࡢ࡯࠿㸪ጤဨ఍࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ጤဨ఍ࡢពぢࢆ⫈࠸࡚㸪ࢭࣥࢱ࣮㛗ࡀᐃࡵࡿࠋ㝃๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸱㸮ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ࡇࡢせ㡯ࡣ㸪௧࿴㸰ᖺ㸵᭶㸶᪥࠿ࡽ᪋⾜ࡋ㸪௧࿴㸰ᖺ㸲᭶㸯᪥࠿ࡽ㐺⏝ࡍࡿࠋᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟せ㡯ᖹᡂ㸱㸮ᖺ㸲᭶㸯᪥ไᐃ㸦㊃᪨㸧➨㸯᮲ ࡇࡢせ㡯ࡣ㸪ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮⣽๎➨㸷᮲➨㸰㡯ࡢつᐃ࡟ᇶ࡙ࡁ㸪⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㸦௨ୗࠕࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ㸧࡟⨨ࡃ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᩍဨ఍㆟㸦௨ୗࠕᩍဨ఍㆟ࠖ࡜࠸࠺ࠋ㸧࡟㛵ࡋᚲせ࡞஦㡯ࢆᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ
㸦ᑂ㆟஦㡯㸧➨㸰᮲ ᩍဨ఍㆟ࡣ㸪ࢭࣥࢱ࣮࡟㛵ࡍࡿḟࡢྛྕ࡟ᥖࡆࡿ஦㡯࡟ࡘ࠸࡚ᑂ㆟ࡍࡿࠋ୍ ࢭࣥࢱ࣮㛗ೃ⿵⪅ࡢ㑅⪃࡟㛵ࡍࡿ஦㡯஧ᩍ⫱⫋ဨࡢᩍ⫱◊✲ᴗ⦼ࡢᑂᰝ࡟㛵ࡍࡿ஦㡯୕ᩍ⫱◊✲ᡓ␎㸪ᩍ⫱◊✲᪉ἲཬࡧᩍ⫱◊✲⤌⧊࡟㛵ࡍࡿ஦㡯ᅄண⟬㓄ศཬࡧỴ⟬࡟㛵ࡍࡿ஦㡯஬ࡑࡢ௚ᩍ⫱㸪◊✲ཬࡧᴗົ࡟㛵ࡍࡿ㔜せ஦㡯

㸦⤌⧊㸧
➨㸱᮲

ᩍဨ఍㆟ࡣ㸪ḟࡢྛྕ࡟ᥖࡆࡿ⪅ࢆࡶࡗ࡚⤌⧊ࡍࡿࠋ୍ ࢭࣥࢱ࣮㛗஧ ࢭࣥࢱ࣮࡟ᡤᒓࡍࡿᑓ௵ࡢᩍ⫱⫋ဨ㸦㆟㛗㸧➨㸲᮲ ࢭࣥࢱ࣮㛗ࡣ㸪ᩍဨ఍㆟ࢆ୺ᐓࡋ㸪ࡑࡢ㆟㛗࡜࡞ࡿࠋ㸰 ࢭࣥࢱ࣮㛗࡟஦ᨾࡀ࠶ࡿ࡜ࡁࡣ㸪ࢭࣥࢱ࣮㛗ࡀ࠶ࡽ࠿ࡌࡵᣦྡࡍࡿᩍᤵࡀࡑࡢ⫋ົࢆ௦⌮ࡍࡿࠋ㸦఍㆟㸧➨㸳᮲ ᩍဨ఍㆟ࡣ㸪ࡑࡢᵓᡂဨࡢ㸱ศࡢ㸰௨ୖࡢฟᖍࢆࡶࡗ࡚ᡂ❧ࡍࡿࠋ㸰 ㆟஦ࡣ㸪ฟᖍ⪅ࡢ㐣༙ᩘࡢྠពࢆࡶࡗ࡚Ỵࡋ㸪ྍྰྠᩘࡢ࡜ࡁࡣ㸪㆟㛗ࡢỴࡍࡿ࡜ࡇࢁ࡟ࡼࡿࠋࡓ
ࡔࡋ㸪ᩍ⫱⫋ဨࡢᩍ⫱◊✲ᴗ⦼ࡢᑂᰝ࡟㛵ࡍࡿ஦㡯࡟ࡘ࠸࡚ࡢ㆟Ỵࡣ㸪ฟᖍ⪅ࡢ㸱ศࡢ㸰௨ୖࡢྠពࢆせࡍࡿࠋ
㸦ᵓᡂဨ௨እࡢ⪅ࡢฟᖍ㸧➨㸴᮲ᨺᑕ⥺ྲྀᢅ᪋タ⟶⌮㈐௵⪅ࡀࢭࣥࢱ࣮௨እࡢᩍ⫱⫋ဨࡢሙྜࡣ㸪ࡑࡢ⪅ࡣ㸪ᩍဨ఍㆟࡟ฟᖍࡋ㸪ពぢࢆ㏙࡭ࡿࡇ࡜ࡀ࡛ࡁࡿࠋ㸦㞧๎㸧➨㸵᮲ ࡇࡢせ㡯࡟ᐃࡵࡿࡶࡢࡢ࡯࠿㸪ᩍဨ఍㆟ࡢ㐠Ⴀࡑࡢ௚࡟㛵ࡍࡿ஦㡯ࡣ㸪ᩍဨ఍㆟ࡢពぢࢆ⫈࠸࡚㸪ࢭࣥࢱ࣮㛗ࡀᐃࡵࡿࠋ㝃๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸱㸮ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ࡇࡢせ㡯ࡣ㸪௧࿴㸰ᖺ㸵᭶㸶᪥࠿ࡽ᪋⾜ࡋ㸪௧࿴㸰ᖺ㸲᭶㸯᪥࠿ࡽ㐺⏝ࡍࡿࠋࢤࣀ࣒◊✲ศ㔝'LYLVLRQRI*HQRPLFV5HVHDUFK
ࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : mgrc@gifu-u.ac.jp
TEL : 058-293-3171
FAX : 058-293-3172

┠‫ ی‬ศ㔝㛗࠶࠸ࡉࡘḟ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

ࢤࣀ࣒◊✲ศ㔝⫋ဨྡ⡙࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭㸦㸧ᑓ௵ᩍဨ
㸦㸧㠀ᖖ໅⫋ဨ㸦㸧◊✲ဨ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

 ௧࿴  ᖺᗘ฼⏝Ⓩ㘓⪅ཬࡧ◊✲ࢸ࣮࣐ࢤࣀ࣒◊✲ศ㔝ඹྠ฼⏝ᶵჾ⤂௓฼⏝ࡢᡭᘬࡁ

௧࿴  ᖺᗘάື≧ἣሗ࿌࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

㸦㸧ㅮ⩦఍࣭ࢭ࣑ࢼ࣮➼㸦㸧ࢤࣀ࣒◊✲ศ㔝฼⏝≧ἣ㸦㸧ඹྠࢫ࣮࣌ࢫ฼⏝≧ἣ㸦㸧௧࿴  ᖺᗘᴗ⦼ㄽᩥ➼㸦㸧௧࿴  ᖺᗘእ㒊㈨㔠㈉⊩ᐇ⦼㸦㸧ࢤࣀ࣒◊✲ศ㔝ᩍဨࡢᩍ⫱◊✲άື➼㸦㸧⿵ຓ㔠㛵㐃᥇ᢥ≧ἣ㸦㸧᪂⪺ሗ㐨➼࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢデ⒪యไࢆ☜❧ࡍࡿࡲ࡛ࡢ◊✲άື ୗ⃝ఙ⾜࣒ࢥከ⢾ࣉࣟࢧ࢖ࢺྲྀᮦ࣏࣮ࣞࢺ

࣭࣭࣭࣭࣭࣭‫ ی‬ศ㔝㛗࠶࠸ࡉࡘࢤࣀ࣒◊✲ศ㔝㛗ᑵ௵࡟࠶ࡓࡾ
ࢤࣀ࣒◊✲ศ㔝㛗㡲㈡ᬕஂࡇࡢᗘࠊ௧࿴㸲ᖺ㸲᭶㸯᪥௜࡛ࢤࣀ࣒◊✲ศ㔝㛗࡟ᑵ௵࠸ࡓࡋࡲࡋࡓࠋᙜศ㔝ࡣࠊᏛෆඹྠ฼⏝᪋タ࡜ࡋ࡚Ⓨ㊊ࡋࡓ㑇ఏᏊᐇ㦂᪋タࡀ๓㌟࡛࠶ࡾࠊ⚾ࡣࡑࡢ❧ୖࡆᮇࡢᖹᡂ㸶ᖺᗘ࠿ࡽඹྠ฼⏝ᶵჾࡢᑟධ࣭⟶⌮ࠊ฼⏝ᣦᑟ࡞࡝ࡢྛ✀ᨭ᥼ᴗົ࡟ᦠࢃࡗ࡚ࡁࡲࡋࡓࠋᙜศ㔝ࢆ࡜ࡾࡲࡃ⎔ቃࡣࡇࢀࡲ้࡛ࠎ࡜ኚࢃࡗ࡚ࡁࡲࡋࡓࡀࠊᩍဨࠊᏛ⏕ࢆၥࢃࡎࠊᏛෆ⏕࿨⛉Ꮫ◊✲ࡢୗᨭ࠼ࢆࡍࡿ࡜࠸࠺࣑ࢵࢩࣙࣥ࡟ኚࢃࡾࡣ࠶ࡾࡲࡏࢇࠋ⏕࿨⛉Ꮫศ㔝㛵㐃ࡢศᯒ⿦⨨ࡣ㛤Ⓨࡸࣂ࣮ࢪࣙࣥ࢔ࢵࣉࡀ┠ࡲࡄࡿࡋࡃࠊࡲࡓࠊ◊✲ࡢࢺࣞࣥࢻࡶ᫬࡜ඹ࡟ኚ໬ࡍࡿࡓࡵ
᪤Ꮡศᯒ⿦⨨ࡢ᭦᪂ࡸ᪂つศᯒ⿦⨨ࡢᑟධࡀᚲせ࡜࡞ࡾࡲࡍࠋࢤࣀ࣒◊✲ศ㔝࡛ࡣ௧࿴㸱ᖺᗘᮎ࡟᪂ࡓ࡟࣐ࣝࢳ࣮ࣔࢻࣉ࣮ࣞࢺ࣮ࣜࢲ࣮㸦1LYR$OSKD6㸧ࢆᑟධ⮴ࡋࡲࡋࡓࠋࡲࡓࠊ᪂つཷクゎᯒࢧ࣮ࣅࢫࡢ㛤ᣅ࡟ࡶຊࢆධࢀ࡚ཧࡾࡲࡋࡓࠋ௧࿴㸲ᖺᗘ࠿ࡽࡣࠊࡇࢀࡲ࡛ࡢᩍဨ
㸱ྡࡀ㸰ྡࡢయไ࡟࡞ࡾࡲࡍࡀࠊࡇࢀࡲ࡛ྠᵝࠊྛ✀⏕࿨⛉Ꮫ◊✲ᨭ᥼ࡢせᮃ࡟ᛂ࠼ࡿ࡭ࡃ
ດࡵ࡚ཧࡾࡲࡍࠋ฼⏝⪅ࡢࡳ࡞ࡉࡲ᪉࡟࠾࠿ࢀࡲࡋ࡚ࡣᘬࡁ⥆ࡁࠊࡲࡔ฼⏝ࡉࢀࡓࡇ࡜ࡀ࡞࠸ ᪉ ࡟ ࠾ ࠿ ࢀ ࡲ ࡋ ࡚ ࡣ ୍ ᗘ ࣍ ࣮ ࣒ ࣌ ࣮ ࢪ

KWWSVZZZJLIXXDFMSaOVUFGJUSRUWDOLQGH[KWPO ࢆࡈぴࡢ࠺࠼ࠊࢤࣀ࣒◊✲ศ㔝ࢆ◊✲࡟ࡈά⏝࠸ࡓࡔࡁࡓࡃࠊ࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ

ࢤࣀ࣒◊✲ศ㔝⫋ဨྡ⡙㸦௧࿴  ᖺᗘ㸧㸦㸯㸧ᑓ௵ᩍဨ㸯 ᩍᤵ㸦ศ㔝㛗㸧     ୗ⃝ ఙ⾜㸰 ෸ᩍᤵ    㡲㈡ ᬕஂ㸱 ຓᩍ    㧗ᓥ ⱱ㞝㸦㸰㸧㠀ᖖ໅⫋ဨὀ㸸㸨͐ᩍဨಶேࡢ◊✲㈝࡛㞠⏝ࠊ㸨㸨͐⑓㝔᳨ᰝ㒊ࡢᡤᒓ㸯 ஦ົ⿵బဨ㸰 ᢏ⾡⿵బဨ
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3 ࢤࣀ࣒◊✲ศ㔝ඹྠ฼⏝ᶵჾ⤂௓(1) DNA 㛵㐃ᶵჾ

1-<2>-(1) ࣜ࢔ࣝࢱ࢖࣒ᐃ㔞 PCR
ABI Step One Plus࢔ࣉࣛ࢖ࢻࣂ࢖࢜ࢩࢫࢸ࣒♫1-<1>-(5) DNA 㓄ิゎᯒࢯࣇࢺ4 Ⰽ㸭96 ࢙࢘ࣝࣇ࢛࣮࣐ࢵࢺ࡛ࠊ⢭ᗘࡢ㧗࠸ᐃ㔞

SEQUENCHER

ࣜ࢔ࣝࢱ࢖࣒ PCR ࢆᐇ⌧ࠋFAM™/SYBR® GreenࠊGene Codes ♫VIC® /JOE™ࠊROX™ࠊTAMRA™࡞࡝ࡢ⺯ගⰍ⣲࢟ࣕࣆ࣮ࣛࣜࢩ࣮ࢣ

ࡀ᳨ฟ࡛ࡁࠊ㑇ఏᏊⓎ⌧ゎᯒࠊ⑓ཎ㑇ఏᏊࡢᐃࣥࢧ࣮ࠊḟୡ௦ࢩ࣮

㔞ࠊSNP ࢪ࢙ࣀࢱ࢖ࣆࣥࢢࠊࣉࣛࢫ/࣐࢖ࢼࢫ࣭࢔

ࢣࣥࢧ࣮(NGS)࠿ࡽ

ࢵࢭ࢖࡞࡝ࡢᐇ㦂ࡀ⏕ᡂࡉࢀࡓ DNA 㓄ฟ᮶ࡿࠋᚑ᮶ࡢಶయ

ิࢆゎᯒࡍࡿࢯࣇࢺ

࡝࠺ࡋࡢẚ㍑ࡢࡳ࡞࢙࢘࢔ࠋἼᙧࢆぢ࡞ࡀࡽࡢࢺ࣑ࣜࣥࢢࡸ࢔ࢵࢭࣥ

ࡽࡎࠊ㞟ᅋ㛫ࡢẚ㍑

ࣈࣝࠊ࣐ࣝࢳࣉࣝ࢔ࣛ࢖࣓ࣥࢺࡸ⣔⤫ᶞసᡂࡀྍ

ࢆ⾜࠺ࡇ࡜ࡀྍ⬟ࠋ⬟ࠋḟୡ௦ࢩ࣮ࢣࣥࢫࢹ࣮ࢱ࡟ࡘ࠸࡚ࡣ FastQC ࡟

2 ྎಖ᭷ࠋ

ࡼࡿ㓄ิṇ☜ᛶࡢ☜ㄆࡸ Velvet ࡟ࡼࡿ de novo ࢔ࢭࣥࣈࣜ࡞࡝ࡀྍ⬟ࠋ

1-<3>-(1) ᰾㓟⢭〇⿦⨨

1-<1>-(3) DNA ከᆺゎᯒࢯࣇࢺ

Maxwellࢪ࣮࣐ࣥࢵࣃ࣮

ࣉ࣓ࣟ࢞♫࢔ࣉࣛ࢖ࢻࣂ࢖࢜ࢩࢫࢸ࣒♫ᵝࠎ࡞ࢧࣥࣉࣝ࠿ࡽ Total RNA

DNA ࣇࣛࢢ࣓ࣥࢺ

ࡢᢳฟ⢭〇ࢆ⾜࠸ࡲࡍࠋࡢࢧ࢖ࢬࢥ࣮ࣝ࠿ࡽ

㧗ရ㉁ࡢ RNA ࢆ෌⌧ᛶⰋࡃᢳ࢔ࣞࣝࢥ࣮ࣝࢆ⾜࠺ฟ࡛ࡁࡲࡍࠋ

ࢪ࢙ࣀࢱ࢖ࣆࣥࢢࢯ
ࣇࢺ࢙࢘࢔ࠋ

ᖹᡂ 28 ᖺ 5 ᭶ᑟධࠋ1-<1>-(4) ࣐ࣝࢳ࢟ࣕࣆ࣮ࣛࣜ DNA ࢩ࣮ࢣࣥࢧ࣮

1-<3>-(2) ᰾㓟⢭〇⿦⨨

3500xL Genetic Analyzer

QuickGene-Auto12S

ࢧ࣮ࣔࣇ࢕ࢵࢩ࣮ࣕࢧ࢖࢚ࣥࢸ࢕ࣇ࢕ࢵࢡ♫ࢡࣛ࣎࢘♫㟁ẼὋື࢟ࣕࣆ࣮ࣛࣜࢆ

㧗⣧ᗘࠊ㧗཰㔞ࡢ DNA/RNA ᅇ཰

24 ᮏ⿦ഛࠋඛ㐍ⓗ࡞ ᗘྍ⬟ࠋ㧗࠸᰾㓟྾╔ᛶ࡜ᐜ᫆࡞⬺ไᚚᶵᵓ࡟ࡼࡾ ᗘࢥࣥࢺ╔ᛶࢆ᭷ࡍࡿ⊂⮬ࡢከᏍ㉁࣓ࣥࣈ

࣮ࣟࣝࡢ⢭ᗘࢆᨵၿࠋ

ࣞࣥࢆ౑⏝ࠋ

RFID㸦↓⥺ IC ࢱࢢ㸧ᢏ⾡࡛ᾘ⪖ရࡢࢹ࣮ࢱࡢ⟶⌮ࠋ
70 ศ࡛ 650 ሷᇶ×24 ヨᩱࡢศᯒࡀྍ⬟ࠋཷクゎᯒ࡟౑⏝ࠋ2 ྎಖ᭷ࠋ2016 ᖺࠊ2020 ᖺᑟධࠋ

1-<5>-(1) ࢚ࣞࢡࢺ࣏࣮ࣟࣞࢱ࣮

1-<3>-(5) ࣂ࢖࢜࢔ࢼࣛ࢖ࢨ࣮
2100 BioAnalyzer

Gene Pulser II࢔ࢪࣞࣥࢺࢸࢡࣀࣟࢪ࣮♫ࣂ࢖࢜ࣛࢵࢻ♫㏻ᖖࠊDNA ศᯒ࡛ࡣࢤࣝ㟁ẼὋືࠊࢱࣥࣃࢡ㉁ศ

࢚ࣞࢡࢺ࣏࣮ࣟࣞࢩࣙࣥ࡜ࡣࠊ㟁Ẽࣃࣝࢫ࡟ࡼࡾ▐ᯒ࡛ࡣ SDS-PAGE ࡛ᚓࡿ⤖ᯝࢆࠊᑓ⏝ࢳࢵࣉࢆ౑

㛫ⓗ࡟⣽⬊࡟✸Ꮝࡋ DNA ➼ࡢ㧗ศᏊࢆ⣽⬊࡟ᑟධ⏝ࡋ࡚▷᫬㛫ࠊ⡆༢࡟ᚓࡿࡓࡵࡢ⿦⨨(᭱኱ 12 ࢧࣥࡍࡿ᪉ἲࠋ኱⭠⳦ࢆࡣࣉࣝࡢᐃᛶ࠾ࡼࡧᐃ㔞ࡌࡵ࡜ࡍࡿ⣽⳦ࡢᙧ㉁ࡢࢹࢪࢱࣝࢹ࣮ࢱࢆ 30㌿᥮ࠊື᳜≀⣽⬊ࡢศ࡛ྲྀᚓྍ⬟)ࠋᢳฟࡋ

DNA ᑟධ࡟౑⏝ࠋࡓ RNA ࡢရ㉁ホ౯ࡶྍ⬟ࠋ

1-<5>-(2) 㑇ఏᏊᑟධ⿦⨨Neon Transfection System

1-<3>-(6) ࣁ࢖ࣈࣜࢲ࢖ࢮ࣮ࢩ࣮ࣙࣥ࢜ࣈࣥ
G2545A

Life Technologies – Invitrogen ♫࢔ࢪࣞࣥࢺࢸࢡࣀࣟࢪ࣮♫᰾㓟ࢆ့ங㢮⣽⬊࡬ᑟධࡍࡿ⿦⨨ࠋ ึ௦ᇵ㣴⣽⬊DNA ࣐࢖ࢡࣟ࢔ࣞ࢖ࡢࣁ࢖ࣈࣜࢲ࢖ࢮ࣮ࢩࣙࣥࡓ

ࡸᖿ⣽⬊࡜࠸ࡗࡓࢺࣛࣥࢫࣇ࢙ࢡࢩࣙࣥࡀ㞴ࡋ࠸ࡵࡢ࢖࣮ࣥ࢟ࣗ࣋ࢱࠋྲྀࡾእࡋྍ⬟࡞࣮ࣟࢱࣛࢵ

⣽⬊ࢆྵࡵࠊከࡃࡢ⣽⬊࡛᭱኱ 90%ࡢᑟධຠ⋡ࢆࢡࢆഛ࠼ࠊᅇ㌿㏿ᗘ࡜ࣁ࢖ᐇ⌧ࠋ 1 ᅇࡢ཯ᛂ࡛ 2×104 ಶ࠿ࡽ 6×106 ಶࡢ⣽⬊࡟ࣈࣜࢲ࢖ࢮ࣮ࢩࣙࣥ ᗘࡢࢺࣛࣥࢫࣇ࢙ࢡࢩࣙࣥྍ⬟ࠋ1 ✀㢮ࡢヨ⸆࡛࠶ࡽࡺタᐃࡀྍ⬟ࠋ᭱኱ 24 ಶࡢࡿࢱ࢖ࣉࡢ⣽⬊࡟౑࢜ࣜࢦ DNA ࣐࢖ࢡࣟ࢔ࣞ

⏝࡛ࡁࡿࠋ࢚ࣞࢡࢺ

࢖⏝ࣁ࢖ࣈࣜࢲ࢖ࢮ࣮ࢩࣙ

࣏࣮ࣟࣞࢩࣙࣥࡢ᮲

ࣥࢳࣕࣥࣂࢆᅛᐃྍ⬟ࠋ௳ࢆไ㝈࡞ࡃ᭱㐺໬ྍ⬟ࠋ
1-<6>-(1) ࣐ࣝࢳࣅ࣮ࢬࣂ࢖࢜࢔ࢵࢭ࢖⿦⨨1-<3>-(7) DNA ࣐࢖ࢡࣟ࢔ࣞ࢖ࢫ࢟ࣕࢼ࣮

Luminex

Array Scan࣑࣏ࣜ࢔♫࢔ࢪࣞࣥࢺࢸࢡࣀࣟࢪ࣮♫ᑡ㔞㸦㹼ȝ/㸧ࡢヨᩱࢆࡶ࡜࡟࣐࢖ࢡࣟࣅ࣮ࢬ࡜

Cy3ࠊCy5ࡢ஧Ⰽἲ࡜

ࣇ࣮ࣟࢧ࢖ࢺ࣓ࢺ࣮ࣜࢆ฼⏝ࡋ࡚᭱኱ 100 㡯┠ࡲ༢Ⰽἲ࡟ᑐᛂࡍࡿ㧗࡛ࢧ࢖ࢺ࢝࢖ࣥࡸࣜࣥ㓟໬ࢱࣥࣃࢡ㉁࡞࡝ࡢᐃ㔞ᶵ⬟ࢫ࢟ࣕࢼࠋゎീᐃࡀ࡛ࡁࡿᗘࡀ  ȝP࡛ 244K/ᯛ

SNPs ࡞࡝

࡞࡝ࡢ㧗ᐦᗘ࢔ࣞ࢖

DNAࠊmicroRNAࡢศᯒࡀྍ⬟ࠋࡢศᯒ࡞࡝࡟ࡶ฼⏝ྍ⬟ࠋ

1-<7>-(1) ࣃࣝࢫࣇ࢕࣮ࣝࢻࢤࣝ㟁ẼὋື⿦⨨(3) ගᏛ⣔ศᯒᶵჾCHEF-DRII
ࣂ࢖࢜ࣛࢵࢻ♫3-<1>-(1) ࣐ࣝࢳ⺯ගࢫ࢟ࣕࢼ࣮

ᩘⓒ࠿ࡽᩘ࣓࣮࢞࣋ࢫ௨ୖࡢ DNA ࡢࢩ࣮ࣕࣉ࡞ศ

Typhoon 9400

㞳ࡀྍ⬟ࠋࢡࣟࣔ

࢔࣐ࢩ࣒ࣕࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫ࢰ࣮࣒࣐ࢵࣆࣥ

ᨺᑕᛶྠ఩య࡜⺯ගࠊࢣ࣑࣑ࣝࢿࢵࢭࣥࢫࡢ 3 ࡘࡢ

ࢢࠊRFLP ศᯒࠊࢫ࣮࢟ࣕࣥࣔࢻ࡜ࠊ㧗࠸ឤᗘ࡜ゎീᗘ࡟ࡼࡿ࣐࢖ࢡ

ࢪ࣮࣐ࣥࢵࣆࣥࢢ

ࣟ࢔ࣞ࢖ゎᯒࠊࣇࣛ

➼࡟౑⏝ࠋࢢ࣓ࣥࢺゎᯒࡸࠊ஧
ḟඖ㟁ẼὋືゎᯒ

1-<8>-(1) UV ࢡࣟࢫ࣮ࣜࣥ࢝

➼࡟ᑐᛂࠋ

GS Gene Linker
BioRad ♫ࢼ࢖࣓ࣟࣥࣥࣈࣞࣥ࡟ࢺࣛࣥࢫࣇ࢓࣮ࡋࡓ

3-<2>-(1),(2) ࣐ࣝࢳࣛ࣋ࣝࣉ࣮ࣞࢺ࣮ࣜࢲ࣮

DNA/RNAࢆᅛᐃࡍࡿ

Wallac 1420 ARVOsx (1)⿦⨨ࠋDNAࢽࢵ࢟ࣥ

Wallac 1420 ARVO SX-DELFIA (2)ࢢࡸ UV⁛⳦ࡶྍ⬟ࠋࣃ࣮࢚࣐࣮࢟ࣥࣝࣛ࢖ࣇࢧ࢖࢚ࣥࢫ♫ẅ⳦ࣛࣥࣉࡣ8࣡ࢵ

1420 ARVOsx ࡣ 96 ࢙࢘ࣝࣉ࣮ࣞࢺࢆࡣࡌࡵࠊᵝࠎ

トᆺ࣭Ἴ㛗 253.7nmࠋࣉ࣮ࣞࢺࢆ⏝࠸࡚⺯ගࠊⓎගࠊ⺯ග೫ගࢆࣁ࢖ࢫࣝ
࣮ࣉࢵࢺ࡛ ᐃྍ⬟ࠋ96ࠊ384ࠊ1536 ࢙࢘ࣝᶆ‽ࣉ
࣮ࣞࢺࠊ6ࠊ12ࠊ24ࠊ48 ࢙࢘ࣝᇵ㣴ࣉ࣮ࣞࢺ࡟ᑐᛂࠋ
ARVOsx-DELFIA ࡣ᫬㛫ศゎ⺯ග ᐃࡀྍ⬟ࠋ(2) ࢱࣥࣃࢡ㉁࣭ࣉࣟࢸ࣮࣒࢜㛵㐃ᶵჾ
3-<2>-(4) ࣐࢖ࢡࣟࣉ࣮ࣞࢺࣇ࢛ࢺ࣓࣮ࢱ࣮

2-<1>-(2) ㉁㔞ศᯒ⿦⨨

Multiskan FC

UPLC-MSࢧ࣮ࣔࣇ࢕ࢵࢩ࣮ࣕࢧ࢖࢚ࣥࢸ࢕ࣇ࢕ࢵࢡ♫᪥ᮏ࢛࣮࢘ࢱ࣮ࢬ♫96 ࢙࢘ࣝ࠾ࡼࡧ 384 ࢙࢘ࣝࣉ࣮ࣞࢺࢆ⏝࠸࡚ 340-

⪏ᅽᛶ࡟ඃࢀࠊ2 ᾮ

850 nm ࡢἼ㛗⠊ᅖ࡛྾ගᗘ

࡟ࡼࡿࢢࣛࢹ࢕࢚ࢆ ᐃྍ⬟ࠋࡍ࡭࡚ࡢ࢙࢘

ࣥࢺศᯒࡀྍ⬟ࠋࣝࢆࡦ࡜ࡘࡢගᏛ⣔࡛ ᐃ

UV ᳨ฟჾࢆഛ࠼࡚

ࡋࡲࡍࠋࢩ࢙࢖࢟ࣥࢢ᧯స

࠸ࡿࠋESI ἲ࡟ࡼࡿࡀྍ⬟ࠋ㉁㔞ศᯒࡀྍ⬟ࠋ

3-<3>-(1) ෭༷ CCD ࣓࢝ࣛ
Ez-࢟ࣕࣉࢳ࣮ࣕAE-9150
ATTO ♫

3-<4>-(3) ศගගᗘィ෭༷ CCD ࣓࢝ࣛࢆ฼⏝ࡋ࡚

BioSpectrometerⓎගࢆ᳨ฟࡍࡿࠋ࢙࢘ࢫࢱ

࢚ࢵ࣌ࣥࢻࣝࣇ♫࣭ࣥࢧࢨ࣭ࣥࣀ࣮ࢨࣥࣈࣟࢵ

200㹼830 nm ⮬⏤㑅ᢥἼࢺ࡟࠾ࡅࡿࢣ᳨࣑࣑ࣝฟ࡞࡝㛗ྍ⬟ࠋ࡟฼⏝ྍ⬟ࠋ

⮬ືẚ⋡ィ⟬࡟ࡼࡗ࡚ࢫ
࣌ࢡࢺࣝࢢࣛࣇ࡟ヨᩱࡢ⣧ᗘࢆ⾲♧࡛ࡁࡿࠋ

3-<3>-(2) ⺯ගⓎග࢖࣓࣮ࢪࣥࢢࢩࢫࢸ࣒
AEQUORIA
὾ᯇ࣍ࢺࢽࢡࢫ♫㉸㧗ឤᗘ෭༷ CCD

3-<5>-(1) ࢖࣓࣮ࢪࣥࢢࢧ࢖ࢺ࣓࣮ࢱ࣮

࣓࢝ࣛ࡟ࡼࡾ⤌⧊ࣞ

IN Cell Analyzer 2200

࣋ࣝࡢ⺯ග࣭ⓎගࡢGE ࣊ࣝࢫࢣ࢔ࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫᳨ฟࡀྍ⬟ࠋ

࣐ࣝࢳ࢙࢘ࣝࣉ࣮ࣞࢺ࡬᧛✀ࡋࡓ⣽⬊➼ࡢ඲⮬ື᧜ᙳཬࡧ⤫ィᏛⓗゎᯒࡀ⾜࠼ࡿࠋ7 Ⰽࡢ༙ᑟయࣛ
ࣥࣉ࡟ࡼࡗ࡚ከⰍ࡛ࡢ⺯ගほᐹ࡜᧜ᙳࡀྍ⬟ࠋ඲

3-<4>-(1) ᚤ㔞ࢧࣥࣉࣝศගගᗘィ⮬ື࡛᧜ᙳࡉࢀࡓ⏬ീࢆ௜ᒓࡢࢯࣇࢺ࢙࢘࢔࡛⤫NanoVueィฎ⌮ࠋ⸆๣ࡢGE ࣊ࣝࢫࢣ࢔ࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫㔞ⓗホ౯ࡸᮍ▱࢟ࣗ࣋ࢵࢺࢆ౑⏝ࡏ⸆๣ࡢࢫࢡ࣮ࣜ

ࡎࠊᑡ㔞ヨᩱࡢ ᐃࡀࢽࣥࢢ࡞࡝࡟ࡶ

ྍ⬟ࠋCyDye ᶆ㆑ࠊ᰾౑⏝ྍ⬟ࠋ㓟⃰ᗘ࣭⣧ᗘࠊࢱࣥࣃ
ࢡ㉁⃰ᗘ࡞࡝ࡢ ᐃ࡟
3-<6>-(1) ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮

౑⏝ࠋࢭࣝ࢔ࢼࣛ࢖ࢨ࣮EC800ࢯࢽ࣮♫3-<4>-(2) ศගගᗘィ⺯ගᢠయ࡛ᶆ㆑ࡋࡓ⣽⬊ࢆ㧗㏿࡟ゎᯒࠋ࣮࢜ࢺࢧ

Ultrospec2100 pro

ࣥࣉ࣮ࣛ࡟ࡼࡿ 48 ࢧࣥࣉࣝ㐃⥆⮬ື ᐃࡀྍ⬟ࠋGE ࣊ࣝࢫࢣ࢔ࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫4 ᮏࡢ࣮ࣞࢨ࣮

⣸እ࠿ࡽྍど㡿ᇦ࡟࠾

㸦405, 488, 561, 642

ࡅࡿヨᩱࡢ྾ගᗘࡀ

nm㸧࡜ 6 ಶࡢ⺯ගᐃ࡛ࡁࡿ⿦⨨ࠋȝOࡢᚤ᳨ฟჾࢆᦚ㍕ࠋ㔞ヨᩱ࡟ᑐᛂࠋ᰾㓟ࡸ
ࢱࣥࣃࢡ㉁ࡢ⃰ᗘ ᐃ࡞࡝࡟฼⏝ࠋ



4-<3>-(1) ṇ❧ᆺ㢧ᚤ㙾

3-<6>-(2) ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮
ࢭࣝࢯ࣮ࢱ࣮SH800

Axioskopࢯࢽ࣮♫࣮࢝ࣝࢶ࢓࢖ࢫ♫⺯ගᢠయ࡛ᶆ㆑ࡋࡓ⣽⬊ࢆศྲྀ㸦ࢯ࣮ࢸ࢕ࣥࢢ㸧ᑐ≀ࣞࣥࢬࡣ 5 ಸࠊ10 ಸࠊ20ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ2 ᪉ྥྠ᫬ࢯ࣮ࢸ࢕ࣥࢢ࠾ࡼࡧ

ಸࠊ40 ಸࡢ 4 ࡘࡀࡘ࠸࡚࠾

96 ࢙࢘ࣝࣉ࣮ࣞࢺࡲ࡛ࡢ࣐ࣝࢳ࢙࢘ࣝࣉ࣮ࣞࢺ࡬ࡾࠊ ࣮࢝ࣛࡢ෗┿᧜ᙳࡶྍࡢࢯ࣮ࢸ࢕ࣥࢢࡀྍ

⬟ࠋࣉࣞࣃ࣮ࣛࢺࡢほᐹࡀྍ⬟ࠋ4 ᮏࡢ࣮ࣞࢨ࣮

⬟ࠋ

㸦405, 488, 561, 638
nm㸧࡜ 6 ಶࡢ⺯ග᳨ฟჾࢆᦚ㍕ࠋ

4-<4>-(1) ᐇయ㢧ᚤ㙾
Stemi 2000 +࣮࢝ࣝࢶ࢓࢖ࢫ♫1.9 ࠿ࡽ 225 ಸࡢಸ⋡࡛ࣂ࢖࢜(4) 㢧ᚤ㙾ࡸᮦᩱヨᩱ⏬ീࢆ࡜ࡽ࠼ࡿࡇ
4-<1>-(2) ඹ↔Ⅼ࣮ࣞࢨ࣮ࢫ࢟ࣕࣥ㢧ᚤ㙾࡜ࡀྍ⬟ࠋ

LSM710

7:1 ࢬ࣮࣒ᶵ⬟࡛ࠊ㐃⥆ྍኚಸ࣮࢝ࣝࢶ࢓࢖ࢫ♫⋡࠿ࡽಶูࡢಸ⋡ࢫࢸࢵࣉࡲ

458, 488, 514, 543, 633 nm ࡢ࣮ࣞࢨ࣮ࢆᦚ㍕ࠋࢱ࢖࡛ኚ᭦ྍ⬟ࠋ

࣒ࢩ࣮ࣜࢬࠊ
FRAPࠊFRET ࡢ௚࡟ࠊࢫ࣌ࢡࢺࣝ࢖
࣓࣮ࢪࣥࢢ㸦㏆᥋

4-<4>-(2) ᐇయ⺯ග㢧ᚤ㙾ࡋࡓ⺯ගࡢศ㞳ࠊ

LEICA MA10Fࢫ࣌ࢡࢺ࣮ࣝ࢝ࣈࣛ࢖࢝♫ࡢ ᐃ㸧ࡶྍ⬟ࠋ×8 ಸ㹼×80 ಸࡲ࡛ࡢ↓ẁ㝵ᣑ኱ほᐹ࡜෗┿᧜ᙳࡀྍ⬟ࠋ⺯ගࡣ⥳Ⰽ⺯ග㸦GFP,

4-<2>-(1) ಽ❧ᆺ⺯ග㢧ᚤ㙾

YFP㸧࡜㉥Ⰽ⺯ග㸦RFP,

Axiovert

DsRed ➼㸧ࢆぢࡿࡇ࡜ࡀ࣮࢝ࣝࢶ࢓࢖ࢫ♫ྍ⬟ࠋ᭱㧗 5 ✀㢮ࡢࣇ࢕ࣝࢱ࣮ࡀ
⿦╔࡛ࡁࡿࠋど㔝ᚄࡀ 23 mm

5-<3>-(1) ࣉࣟࢸ࣑࢜ࢡࢫᨭ᥼ࢩࢫࢸ࣒

(5) ࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ㛵㐃ᶵჾ

MASCOT
Matrix Science ♫5-<1>-(1) 㟁ẼὋືࢤࣝ⏬ീゎᯒ⿦⨨

ࢱࣥࣃࢡ㉁ࡢ㑇ఏᏊྠᐃࢆᨭ᥼ࡍࡿࢩࢫࢸ࣒ࠋࢹ

Image Master Platinum࣮ࢱ࣮࣋ࢫࢆࡶ࡜࡟௬᝿ୖࡢ࣌ࣉࢳࢻ᩿∦ࡢ ࢭ࢔࣐ࢩ࣒ࣕࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫ࢵࢺࢆⓎ⏕ࠊMALDI-TOF ࡟ࡼࡿ࣌ࣉࢳࢻ MS ࣇ࢕஧ḟඖ㟁ẼὋື࡛ศ㞳ࡉࢀࡓࢱࣥࣃࢡ㉁ࢫ࣏ࢵࢺ

࣮ࣥ࢞ࣉࣜࣥࢸ࢕ࣥࢢ

ࣃࢱ࣮ࣥࠊ➼㟁ⅬࠊศᏊ㔞ࠊ࣮࣒࣎ࣜࣗ➼ࢆゎᯒࠋ
ImageMaster 2D Eliteࠊ2D Database ࡣ 2 ✀㢮௨ୖࡢࢤࡸ TOF/TOF ゎᯒ࡛ᚓࡽࢀࡿヨᩱࡢࢹ࣮ࢱ࡜

ࣝࡢẚ㍑ゎᯒ࠿ࡽࢫ࣏ࢵࢺࡢ᭷↓ࠊቑῶࡢᩘ್໬ࡸ

↷ྜࡍࡿࡇ࡜࡟ࡼࡾ㑇ࢹ࣮ࢱ࣮࣋ࢫ໬ࢆࢧ࣏࣮ࢺࠋࢤࣝࠊࣈࣟࢵࢸ࢕ࣥࢢ

ఏᏊࢆྠᐃࠋ

࣓ࣥࣈࣞࣥࡢ⏬ീࡣࢹࢫࢡࢺࢵࣉࢫ࢟ࣕࢼ࣮
Image Scanner ࡲࡓࡣࣂ5-<3>-(2) ࣉࣟࢸ࣑࢜ࢡࢫᨭ᥼ࢩࢫࢸ࣒

ࣜ࢔ࣈࣝ࢖࣓࣮ࢪ࢔ࢼ

ProteinLynx Global SERVER 㸦PLGS㸧ࣛ࢖ࢨ࣮Typhoon ࡞࡝

Waters ♫ࡢ⏬ീゎᯒ⿦⨨࠿ࡽࡣ

Waters Xevo Qtof ࡢ⢭ᐦ㉁㔞ࢹ࣮ࢱࢆᇶ࡜ࡋ࡚ࠊ⊂TIFF ᙧᘧࡢྲྀࡾ㎸ࡳࡀ⮬ࡢࣇ࢕ࣝࢱࣜࣥࢢᶵ⬟ࡸィ⟬ᶵ⬟ࢆ⏝࠸࡚ゎᯒྍ⬟ࠋࢆ⾜࠺ࠊᐃ㔞ⓗ࠾ࡼࡧ୺せᶵ⬟ᐃᛶⓗࣉࣟࢸ࣑࢜ࢡࢫ࣭ ࢫ࣏ࢵࢺ᳨▱ࠊࣂࢵࢡࢢࣛ࢘ࣥࢻ๐㝖◊✲ࡢ MS ࢖ࣥࣇ࢛࣐

࣭ 100 ᯛࡲ࡛ࡢ⮬ືࢫ࣏ࢵࢺ࣐ࢵࢳࣥࢢ

ࢸ࢕ࢡࢫࣉࣛࢵࢺࣇ࢛࣭ ࣐࣮࣮࢝/࣐࣮࣮࢝ࢫ࣏ࢵࢺ࠿ࡽࡢศᏊ㔞࣭➼㟁

࣮࣒ࠋ

ⅬỴᐃ
࣭ ࣐ࢵࢳࣥࢢࢫ࣏ࢵࢺࡢ㔞ኚ໬ࡢ⾲♧5-<4>-(1) ศᏊ㛫ࢿࢵࢺ࣮࣡ࢡ/ࣃࢫ࢙࢘࢖ゎᯒ࣭ ࢖ࣥࢱ࣮ࢿࢵࢺࢹ࣮ࢱ࣮࣋ࢫࡢ᳨⣴ࢹ࣮ࢱ࣮࣋ࢫ

࣭ 2D DIGE ࡟ᑐᛂ

IPAࢺ࣑࣮ࢹࢪࢱࣝࣂ࢖࢜ࣟࢪ࣮♫5-<2>-(1) ⺮ⓑ㉁❧యᵓ㐀᝟ሗゎᯒ⿦⨨࣐࢖ࢡࣟ࢔ࣞ࢖ࡸ࣓ࢱ࣑࣎ࣟࢡࢫࠊࣉࣟࢸ࣑࢜ࢡ

DSModelingࢫࠊRNA-Seq ࡞࡝ࡢᐇ㦂ࡼࡾᚓࡽࢀࡓࢹ࣮ࢱࢆࡶ

Accelrys ♫࡜࡟ࡋ࡚⏕≀Ꮫⓗ࡞ᶵ⬟ࡢゎ㔘ࡸࣃࢫ࢙࢘࢖ゎᯒ

⺮ⓑ㉁࣭᰾㓟ࡢ❧యᵓ㐀ࢆ 3 ḟඖⓗ࡟ྍど໬ࡍࡿࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࢯࣇࢺ࢙࢘࢔ࠋ㇏ᐩ࡞┦஫స⿦⨨ࠋ࣍ࣔࣟࢪ࣮ࣔࢹࣜࣥࢢἲ࡜࣮ࣔࣞ࢟ࣗࣛࢲ

⏝᝟ሗࡸศᏊ᝟ሗࡀࢹ࣮ࢱ࣮࣋ࢫ໬ࡉࢀ࡚࠸ࡿࡓ

࢖ࢼ࣑ࢵࢡࢫἲ࡟

ࡵࠊศᏊ⏕≀Ꮫࡢ㎡᭩࡜ࡋ࡚ࡶ౑⏝ྍ⬟ࠋࡼࡾ㧗ศᏊࡢ❧యᵓ㐀ࢆண ࡍࡿࢩࢫࢸ࣒ࠋ

5-<5>-(1) ࣐࢖ࢡࣟ࢔ࣞ࢖⏝ࢹ࣮ࢱゎᯒ(7) 㐲ᚰศ㞳ᶵࢯࣇࢺ࢙࢘࢔
GeneSpring

7-<1>-(1) ㉸㐲ᚰศ㞳ᶵࢺ࣑࣮ࢹࢪࢱࣝࣂ࢖࢜ࣟࢪ࣮♫Optima L-70K

㑇ఏᏊⓎ⌧࢔ࣞ࢖࡞࡝ࡢᩘ್ゎᯒࠊ⏕≀Ꮫⓗゎᯒ࣋ࢵࢡ࣐ࣥࢥ࣮ࣝࢱ࣮♫࡞࡝ࠊࡉࡲࡊࡲ࡞ᶵ⬟ࢆᦚ㍕ࡋࡓࢹ࣮ࢱ࣐࢖ࢽࣥ

᭱㧗 70 kUSP ࠋ10 PO × 6 ᮏࢢࢯࣇࢺ࢙࢘࢔ࠋ㑇ఏᏊⓎ⌧ゎᯒᶵ⬟࡟ຍ࠼ࠊࡢ㉸㐲ᚰศ㞳ࡀྍ⬟ࠋ

miRNAࠊReal Time PCRࠊCNVࠊSNPࠊPathway ゎᯒ➼ࡶ⾜࠺஦ࡀྍ⬟ࠋ

7-<3>-(1) ෾⤖஝⇱ᶵ
FDU-810EYELA ♫
ᑡ㔞࠿ࡽẚ㍑ⓗከ㔞࡞ࡓࢇࡥࡃ㉁ࠊ㓝⣲➼ࡢ(6) ࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮࣭㟁ẼὋືᶵჾᕼ㔘Ỉ⁐ᾮࡢ⃰⦰ཬࡧ஝⇱ࠊ⏕యヨᩱࡢ⃰⦰ཬࡧ஝⇱ ࠋ

6-<2>-(1) ➼㟁Ⅼ㟁ẼὋືࢩࢫࢸ࣒
IPGphor + SE600 Ruby+Ettan Dalt6࢔࣐ࢩ࣒ࣕࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫➼㟁Ⅼ㟁ẼὋື࡜ SDS ࣏ࣜ࢔ࢡࣜࣝ࢔࣑ࢻࢤࣝ㟁ẼὋື࡟ࡼࡾࠊᩘ༓ಶࡢࢱࣥࣃࢡ㉁ࢆ 2 ḟඖ࡛ᒎ(8) ᇵ㣴ᶵ࣭⣽⬊◚○ᶵ㛤ࠋ
8-<4>-(1) ᐦ㛢ᆺ㉸㡢Ἴ◚○ᶵBiorupterࢥࢫࣔࣂ࢖࢜♫ᐦ㛢ᘧ࡛」ᩘヨᩱࡢྠ᫬㉸㡢Ἴฎ⌮ࡀྍ⬟ࠋ
10 ml ⏝ࢫࣆࢵࢶ࡞ࡽ᭱
኱ 24 ᮏࠊ1.5 ml ࣐࢖ࢡࣟࢳ࣮ࣗࣈ࡞ࡽ 24 ᮏࠊ50
ml ࢳ࣮ࣗࣈ࡞ࡽ 12 ᮏࠋ࣐ࣝࢳࢱ࢖࣐࣮࡟ࡼࡾ◚○᫬㛫ࡢࢭࢵࢺࡀྍ⬟ࠋ

8-<4>-(2) ᐦ㛢ᆺ㉸㡢Ἴ◚○ᶵ

8-<5>-(1) ᐦ㛢ᆺ㉸㡢Ἴ◚○ᶵࣅ࣮ࢬᘧ࣍ࣔࢪࢼ࢖ࢨ࣮

࣏ࣜࢺࣟࣥ࣍ࣔࢤࢼ࢖ࢨ࣮ PT-2100

࣐ࣝࢳࣅ࣮ࢬࢩࣙࢵ࣮࢝MB455GU(S)Kinematica ♫Ᏻ஭ჾᲔᰴᘧ఍♫ࢻࣛ࢖ࣈࢩࣕࣇࢺࡢඛ➃࡟࠶ヨᩱࢆ࢞ࣛࢫࣅ࣮ࢬࡸ࣓ࢱࣝࢥ࣮ࣥ࡜ඹ࡟᧠ᢾࡍࡿᅇ㌿ลࢆ㧗㏿࡛ᅇ㌿ࡉࡏࡿࡿࡇ࡜࡛◚○ࠋヨᩱ㛫ࡢࢡࡇ࡜࡛⏕ࡌࡿỈὶ࡜ࠊ࢟ࣕࣅ

ࣟࢫࢥࣥࢱ࣑ࢿ࣮ࢩࣙࣥࡸ

ࢸ࣮ࢩࣙࣥ࡟ࡼࡿ㉸㡢Ἴ࡛ヨRase ࡢΰධࢆ㜵Ṇࠋ㓝ᩱࢆ◚○ࠋື≀ࡸ᳜≀ࡢ⤌⧊ẕࠊࣂࢡࢸࣜ࢔ࠊ࢝ࣅࠊ

࠿ࡽࡢ RNA ᢳฟ➼࡟౑⏝ࠋᅛ ࠸ື≀⤌⧊ࠊ᳜≀⤌⧊ࢆᩘ ༑⛊ࠥᩘศ࡛◚○ࠋู⣬ ࢤࣀ࣒◊✲ศ㔝฼⏝ᩱ㔠⾲                      ௧࿴ 4.5.1 ⌧ᅾ஦     㡯ᩱ㔠ഛ⪃

1. Ⓩ㘓ᩱ
Ⓩ㘓ᩱ

1,000 ෇/ࢢ࣮ࣝࣉ࣭ᖺ

ͤᖺᗘẖࡢ᭦᪂
㸦4/1 㹼3/31㸧

200 ෇/ࢧࣥࣉࣝ
1~71 ࢧࣥࣉ
ࣝ
700 ෇/ࢧࣥࣉͤ96 ࢧࣥࣉࣝ௨ୖ   150 ෇/ࢧࣥࣉࣝࣝ
1~21 ࢧࣥࣉࣝ  ༢౯ኚື

2. ཷクᩱ㔠⾲ ͤ nn! n ࡣ⟶⌮␒ྕ
DNA ཷクゎᯒ! 

DNA ࢩ࣮ࢣࣥࢧ࣮㸦཯ᛂ῭㸧! 

DNA ࢩ࣮ࢣࣥࢧ࣮㸦཯ᛂ๓㸧ͤ22㹼29 ࢧࣥࣉࣝ
ͤ30㹼66 ࢧࣥࣉࣝ  500 ෇/ࢧࣥࣉࣝ
ͤ67㹼94 ࢧࣥࣉࣝ  ༢౯ኚື
ͤ95 ࢧࣥࣉࣝ௨ୖ
  350 ෇/ࢧࣥࣉࣝͤ኱㔞ࢧࣥࣉࣝᛂ┦ㄯ! 

DNA ࢩ࣮ࢣࣥࢧ࣮
㸦ࣇࣛࢢ࣓ࣥࢺゎᯒ㸧

200 ෇/ࢧࣥࣉࢩ࣮ࢣࣥࢫ࢜ࣉࢩࣙࣥࢧ࣮ࣅࢫ
㸦PCR ቑᖜ࣭PCR ⏘≀⢭〇࡞࡝㸧ಶู┦ㄯࣝ
1~71 ࢧࣥࣉࣝ!

ࣜ࢔ࣝࢱ࢖࣒ PCR ࢜ࣉࢩࣙࣥࢧ࣮ࣅࢫ  (ࣉࣛ࢖࣐࣮タィ࣭ቑᖜ☜ㄆ࡞࡝)ͤ96 ࢧࣥࣉࣝ௨ୖ
  150 ෇/ࢧࣥࣉࣝಶู┦ㄯRNA ཷクゎᯒ! 

Promega Maxwell㸦RNA ᢳฟ⢭〇ཷク㸧

! ࣂ࢖࢜࢔ࢼࣛ࢖ࢨ Agilent 2100
㸦RNA ཷクศᯒ㸧⣽⬊ 850 ෇/
1 ࢧࣥࣉࣝ
⤌⧊ 1200 ෇/
1 ࢧࣥࣉࣝͤ ⃰ᗘ⣧ᗘ ᐃྵࡴͤ BioAnalyzer ࡟ࡼࡿရ㉁ࢳ࢙ࢵࢡࡣูᩱ㔠5,000 ෇/ศᯒ
1~12 ࢧࣥࣉࣝͤ ヨ⸆࣭ࢳࢵࣉ௦ྵࡴͤ ࢳࢵࣉࡢࡳ 3,000 ෇

30,000/1 ࢧࣥࣉࣝ
ࢫࣛ࢖ࢻࡣᐇ㈝࢔ࣞ࢖ࢫࣛ࢖ࢻ௦㔠ࡢ┠

10,000 ෇/
1 ࢧࣥࣉࣝͤ ┦ྠᛶ᳨⣴ྵࡴ࣐࢖ࢡࣟ࢔ࣞ࢖ཷクゎᯒ! ࣐࢖ࢡࣟ࢔ࣞ࢖ࢫ࢟ࣕࢼᏳ        
࣭8 ࢔ࣞ࢖̿⣙ 25 ୓෇
࣭4 ࢔ࣞ࢖̿⣙ 13 ୓෇

16SrRNA 㓄ิゎᯒ
16SrRNA 㓄ิゎᯒ㸦⣽⳦ࡢྠᐃ㸧
ࢱࣥࣃࢡ㉁࣭ࣉࣟࢸ࣮࣒࢜㛵㐃ᶵჾ

2-<1>-(2)㉁㔞ศᯒ⿦⨨ UPLC-MSಶู┦ㄯ㉳ື࣭⤊஢ 3,000 ෇/1ᅇ࣮ࣝࢳࣥ ᐃ 1,000 ෇/1 ⎼᮲௳᳨ウ 8,000 ෇/1 ᑐ㇟≀ᵓ㐀ゎᯒ 5,000 ෇/1 ᑐ㇟≀◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊ࡟ࡼࡿཷクゎᯒࢤࣀ࣒⦅㞟⣽⬊సᡂ㸦CRISPR/Cas9

gRNA タィ࣭

࢜ࣉࢩࣙࣥ

౑⏝㸧

ㄪᩚࠊ⣽⬊࡟

96 ࢙࢘ࣝࣉ࣮ࣞࢺ࡬ࡢ

࠾ࡅࡿኚ␗ᑟ

⣽⬊ࡢ༢㞳:3,000 ෇/1

ධຠ⋡☜ㄆ

ࣉ࣮ࣞࢺ

50,000 ෇ኚ␗ᑟධ⣽⬊ࡢࢩ࣮ࢡ/1 ࢧࣥࣉࣝ

࢚ࣥࢫ:10,000 ෇/8 ࢡ࣮ࣟࣥ」ᩘࡢ࢞࢖ࢻ RNA ࡢ౑⏝:10,000 ෇/1 ࢧࣥࣉࣝࢤࣀ࣒⦅㞟࣐࢘ࢫసᡂ㸦CRISPR/Cas9

gRNA タィ࣭gRNA ㄪᩚᚋࡢཷ⢭༸౑⏝㸧ㄪᩚࠊ⣽⬊࡟

࡬ࡢ࢚ࣞࢡࢺ࣏࣮ࣟࣞ

࠾ࡅࡿࡢࢤࣀ

ࢩ࣭ࣙࣥ⬇⛣᳜ࡲ࡛ࡢ࣒⦅㞟ຠᯝࡢ

ሙྜࡣ 100,000 ෇☜ㄆࠊཷ⢭༸

/1 ࢧࣥࣉࣝ

࡬ࡢ࢚ࣞࢡࢺ
࣏࣮ࣟࣞࢩࣙ
࣭ࣥ⬇⛣᳜ࡲ
࡛
150,000 ෇/1 ࢧࣥࣉࣝ
㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾ほᐹ

1 ࢧࣥࣉࣝࡢ

2㹼4 ࢧࣥࣉࣝࡢሙྜࡢ

ࡳࡢሙྜ

1 ࢧࣥࣉࣝ࠶ࡓࡾ༢౯

ᚋᅛᐃ(1,000

ᚋᅛᐃ(500 ෇)ࠊ⬺Ỉ෇)ࠊ⬺Ỉ࣭ࣇ࣮ࣜࢬࢻࣛ࢖

࣭ࣇ࣮ࣜࢬࢻ

(1,000 ෇)ࠊ࢜ࢫ࣑࣒࢘

ࣛ࢖(2,000ࢥ࣮ࢸ࢕ࣥࢢ(1,000෇)ࠊ࢜ࢫ࣑෇)ࠊほᐹ࣭᧜ᙳ(1,000࣒࢘ࢥ࣮ࢸ࢕

෇)ࣥࢢ(2,000෇)ࠊほᐹ࣭
᧜ᙳ(1,000෇)ィ 6,000 ෇(࢜ࣉࢩࣙࣥ:⣽⬊ᇵ㣴
2,000 ෇/4 ࢧࣥࣉࣝࡲ࡛)
3. ඹྠ฼⏝ᶵჾᩱ㔠⾲ ͤn-<n>-(n)ࡣ⟶⌮␒ྕ
DNA 㛵㐃ᶵჾ! 

DNA ࢩ࣮ࢣࣥࢧ࣮3500

ཷクᩱ㔠⾲ཧͤ ┦クࡢࡳ↷! 

DNA ከᆺゎᯒࢯࣇࢺ ࢪ࣮࣐ࣥࢵࣃ࣮---! 

DNA 㓄ิゎᯒࢯࣇࢺ SEQUENCHER---

!  ࣜ࢔ࣝࢱ࢖࣒ᐃ㔞 PCR
ABI Step one plus! ࣂ࢖࢜࢔ࢼࣛ࢖ࢨ
Agilent 2100

! ࣁ࢖ࣈࣜࢲ࢖ࢮ࣮ࢩ࣮ࣙࣥ࢜ࣈࣥ
  Agilent G2545A

1,000 ෇/౑⏝! ࣐࢖ࢡࣟ࢔ࣞ࢖ࢫ࢟ࣕࢼ
  Agilent ArrayScan

1,000 ෇/ࢫ࢟ࣕࣥ! ࢚ࣞࢡࢺ࣏࣮ࣟࣞࢱ࣮
Gene Pulser II㈚ฟࡢሙྜ
100 ෇/㐌! 㑇ఏᏊᑟධ⿦⨨Neon Transfection system㈚ฟࡢሙྜ
100 ෇/᪥ͤ฼⏝ࡣせ┦ㄯ    
ͤ10 Pl ࢟ࢵࢺ 2,000 ෇/
1 ౑⏝

! ࣐ࣝࢳࣅ࣮ࢬࣂ࢖࢜࢔ࢵࢭ࢖⿦⨨Luminex

500 ෇/౑⏝ͤ฼⏝ࡣせ┦ㄯ! ࣃࣝࢫࣇ࢕࣮ࣝࢻࢤࣝ㟁ẼὋື⿦⨨
CHEF-DRII

500 ෇/Ὃືͤ฼⏝ࡣせ┦ㄯ! 

UV ࢡࣟࢫ࣮ࣜࣥ࢝ GS Gene Linker---

ͤ฼⏝ࡣせ┦ㄯ500 ෇/౑⏝---ࢱࣥࣃࢡ㉁࣭ࣉࣟࢸ࣮࣒࢜㛵㐃ᶵჾ! ㉁㔞ศᯒ⿦⨨ UPLC-MS

1,000 ෇/౑⏝ගᏛ⣔ศᯒᶵჾ
! ࣐ࣝࢳ⺯ගࢫ࢟ࣕࢼ Typhoon 9400

500 ෇/౑⏝! ࣐ࣝࢳࣛ࣋ࣝࣉ࣮ࣞࢺ࣮ࣜࢲ࣮
  Wallac1420 ARVO SX

300 ෇/᫬㛫! ࣐ࣝࢳࣛ࣋ࣝࣉ࣮ࣞࢺ࣮ࣜࢲ࣮
  Wallac1420 ARVO SX-DELFIA300 ෇/᫬㛫! ࣐ࣝࢳ࣮ࣔࢻࣉ࣮ࣞࢺ࣮ࣜࢲ࣮

300 ෇/᫬㛫  Nivo Alpha S! ࣐࢖ࢡࣟࣉ࣮ࣞࢺࣇ࢛ࢺ࣓࣮ࢱ࣮

---  Multiskan FC! ෭༷ CCD ࣓࢝ࣛ Ez-࢟ࣕࣉࢳ࣮ࣕ
AE-9150

250 ෇/᫬㛫ͤ 1 ౑⏝=3 ᫬㛫㎾㸦3 ᫬㛫௨ୖ౑⏝ =2 ౑⏝㹼㸧ͤ ࢳࢵࣉ 3,000 ෇/1 ᯛͤ ཷクศᯒࡣཷクᩱ㔠⾲ཧ↷! ⺯ගⓎග࢖࣓࣮ࢪࣥࢢࢩࢫࢸ࣒
AEQUORIA

500 ෇/౑⏝! ᚤ㔞ࢧࣥࣉࣝศගගᗘィ NanoVue---

! ศගගᗘィ Ultrospec2100 pro---

! ࢖࣓࣮ࢪࣥࢢࢧ࢖ࢺ࣓࣮ࢱ࣮
  IN Cell Analyzer㸦᧜ᙳ㸧

500 ෇/౑⏝! ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮ ࢭࣝ࢔ࢼࣛ࢖

500 ෇/౑⏝ͤ฼⏝ࡣせ┦ㄯͤゎᯒࢯࣇࢺࡢࡳࡢ
฼⏝ࡣ↓ᩱ

ࢨ࣮
EC800
! ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮ ࢭࣝࢯ࣮ࢱ࣮
SH800

500 ෇/౑⏝ඹ↔Ⅼ࣮ࣞࢨ࣮ࢫ࢟ࣕࣥ㢧ᚤ㙾 LSM

1,000 ෇/౑⏝ͤࢳࢵࣉ 3,000 ෇/1 ᯛ㢧ᚤ㙾! 710
! ಽ❧ᆺ⺯ග㢧ᚤ㙾 Axiovert

250 ෇/౑⏝! ᐇయ⺯ග㢧ᚤ㙾 LEICA MZ 10F

250 ෇/౑⏝! ṇ❧㢧ᚤ㙾 Axioskop---! ᐇయ㢧ᚤ㙾 Stemi 2000---ͤ⺯ග౑⏝᫬ࡢࡳ

ࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ㛵㐃ᶵჾ! ࣉࣟࢸ࣑࢜ࢡࢫᨭ᥼ࢩࢫࢸ࣒
MASCOT---! ࣉࣟࢸ࣑࢜ࢡࢫᨭ᥼ࢩࢫࢸ࣒
  ProteinLynx Global SERVER---! ศᏊ㛫ࢿࢵࢺ࣮࣡ࢡ/ࣃࢫ࢙࢘࢖ゎᯒࢹ࣮ࢱ࣮࣋ࢫ---! ࣐࢖ࢡࣟ࢔ࣞ࢖⏝ࢹ࣮ࢱゎᯒࢯࣇࢺ࢙࢘࢔
  GeneSpring

IPAͤ฼⏝ࡣせ┦ㄯ---ࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮࣭㟁ẼὋື㛵㐃ᶵჾ! ➼㟁Ⅼ㟁ẼὋືࢩࢫࢸ࣒
  IPGphor+SE600 Ruby+Ettan Dalt6

1,000 ෇/౑⏝㐲ᚰศ㞳ᶵ! ㉸㐲ᚰศ㞳ᶵ Optima L-70K

! ෾⤖஝⇱ᶵ FDU-810--500 ෇/24 ᫬㛫ᇵ㣴ᶵ࣭⣽⬊◚○ᶵ! ᐦ㛢ᆺ㉸㡢Ἴ◚○ᶵ Biorupter---! ࣅ࣮ࢬᘧ࣍ࣔࢪࢼ࢖ࢨ࣮  ࣐ࣝࢳࣅ࣮ࢬࢩࣙࢵ࣮࢝
MB455GU(S)100 ෇/౑⏝! ࣏ࣜࢺࣟࣥ࣍ࣔࢤࢼ࢖ࢨ࣮ PT-2100---

3.ᐇ㦂ᐊ࣭ᐇ㦂ྎᐇ㦂ྎ㸦1 ࢫ࣮࣌ࢫศ:୰ኸᐇ㦂ྎ༙ศ㸧

10,000 ෇/᭶ͤ฼⏝ࡣせ┦ㄯ

5,000 ෇/᭶᳜≀⏝ࢢ࣮ࣟࢫ࢟ࣕࣅࢿࢵࢺ
ࢥ࢖ࢺࢺࣟࣥ㸦401㸧᳜≀᱂ᇵᐊ

10,000 ෇/᭶



P1

ᐊ

50,000 ෇/᭶◊ಟࢭ࣑ࢼ࣮ᐊ

400 ෇/᫬㛫ͤᏛእࡢࡳㄢ㔠100 ෇㹼500 ෇㸨ᅵ᪥⚃᪥௚
ᙜศ㔝ࡀᐃࡵࡿఇ㤋᪥

4. ᫬㛫እ฼⏝ᩱ㔠᫬㛫እ฼⏝ᩱ㔠

/౑⏝





฼⏝ࡢᡭᘬࡁ฼⏝⪅㈨᱁࣭Ⓩ㘓ձ ฼⏝⪅㈨᱁
ᒱ㜧኱Ꮫ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝㸦௨ୗࠕࢤࣀ࣒◊✲ศ㔝ࠖ࡜࠸࠺ࠋ㸧ࢆ฼⏝࡛ࡁࡿ⪅ࡣࠊᒱ㜧኱Ꮫཬࡧᒱ㜧⸆⛉኱Ꮫࡢ⫋ဨࠊ኱Ꮫ㝔⏕ࠊᏛ⏕ཬࡧࢤࣀ࣒◊✲ศ㔝㛗㸦௨ୗࠕศ㔝㛗ࠖ࡜࠸࠺ࠋ㸧ࡀ㐺ᙜ࡜ㄆࡵࡓ⪅࡜ࡍࡿࠋղ ฼⏝⪅࣭฼⏝㈐௵⪅࣭⤒㈝㈇ᢸ㈐௵⪅฼⏝࡟㝿ࡋ࡚ࡣࠊ฼⏝㈐௵⪅ ฼⏝࡟ࡘ࠸࡚ࡢ㈐௵ࢆᣢࡘ⪅࡛ࠊᩍဨ࡟㝈ࡿ ࡼࡾࠊ⤒㈝㈇ᢸ㈐௵⪅฼⏝࡟ಀࡿ⤒㈝࡟ࡘ࠸࡚㈐௵ࢆᣢࡘ⪅࡛ࠊᩍဨ࡟㝈ࡿ ࡜฼⏝⪅ࢆ᫂グࡋࡓ฼⏝Ⓩ㘓⏦ㄳ᭩ࢆศ㔝㛗࡟ᥦฟࡋ࡚ᢎㄆࢆᚓ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋⓏ㘓ᮇ㛫ࡣ฼⏝㛤ጞ᪥࠿ࡽ฼⏝㛤ጞ᪥ࡢᒓࡍࡿᖺᗘᮎࡲ
࡛ࢆ㝈ᗘ࡜ࡍࡿࠋࡲࡓࠊඹྠ฼⏝ᶵჾࡢ฼⏝⪅࡟ࡘ࠸࡚ࡣࠊᢎㄆࢆᚓࡓ⪅ࡢ࠺ࡕヱᙜᶵჾࡢㅮ⩦఍ࡸࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫ࡟ཧຍࡋࡓ⪅ࠊ᧯స࡟⩦⇍ࡋࡓ⪅ཬࡧ᧯స࡟⩦⇍ࡋࡓ⪅ࡢୗ࡛฼⏝ࡍࡿࡶࡢ࡜
ࡍࡿࠋճ ฼⏝Ⓩ㘓⏦ㄳ᪉ἲ
฼⏝Ⓩ㘓⏦ㄳࡢ᪉ἲ࡟ࡘ࠸࡚ࡣࠊࢤࣀ࣒◊✲ศ㔝ࡢ࣮࣒࣮࣍࣌ࢪෆ ࠕ฼⏝Ⓩ㘓⏦ㄳࠖࡢ㡯ࢆཧ↷ࡋ࡚฼⏝㈐௵⪅ࡀ⏦ㄳࡍࡿࠋմ Ⓩ㘓ෆᐜࡢኚ᭦࣭฼⏝୰Ṇ
Ⓩ㘓⏦ㄳ᭩ࡢグ㍕஦㡯࡟ኚ᭦ࡀ⏕ࡌࡓ㝿ࠊཪࡣࢤࣀ࣒◊✲ศ㔝ࡢ฼⏝ࢆ୰Ṇࡋࡓ㝿ࠊ฼⏝㈐௵⪅ࡣ㏿ࡸ࠿࡟ࠊࡑࡢ᪨ࢆศ㔝㛗࡟ᒆࡅฟࡿ࡜ඹ࡟ࠊኚ᭦ࡢሙྜࡣᢎㄆࢆᚓ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋյ ฼⏝ᢎㄆࡢྲྀᾘࡋ
฼⏝⪅ࡀἲ௧ཬࡧᒱ㜧኱Ꮫつ๎ࢆ㑂Ᏺࡋ࡞࠸ሙྜࡸࢤࣀ࣒◊✲ศ㔝ࡢ㐠Ⴀ࡟ᨭ㞀ࢆ⏕ࡌࡉࡏࡿሙྜࠊ
ศ㔝㛗ࡣ฼⏝ᢎㄆࢆྲྀᾘࡍࡇ࡜ࠊཪࡣ୍ᐃᮇ㛫ࡑࡢ⪅ࡢ฼⏝ࢆ೵Ṇࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿࠋ฼⏝ᩱ฼⏝࡟ಀࡿᩱ㔠ࡣࠊู㡯ࡢᩱ㔠⾲࡟ᚑࡗ࡚⤒㈝㈇ᢸ㈐௵⪅ࡀ㈇࠺ࡶࡢ࡜ࡋࠊ㐠Ⴀ㈝஺௜㔠ࠊᐤ௜㔠ࠊཷク◊✲㈝ࠊ⛉Ꮫ◊✲㈝⿵ຓ㔠ࡢ᣺᭰࡟ࡼࡾ⾜࠺ࠋᴗ⦼ࡢᥦฟ࡟ࡘ࠸࡚฼⏝㈐௵⪅ࡣࠊḟᖺᗘ࡟฼⏝ࢆ⥅⥆ࡍࡿሙྜࡣ๓ᖺศ 㹼 ᭶ ࠊḟᖺᗘ࡟฼⏝ࢆ⥅⥆ࡋ࡞࠸ሙྜࡣ
ᙜヱᖺᗘࡢᴗ⦼ ㄽᩥ࣭ⴭ᭩ ࢆࠊ฼⏝Ⓩ㘓⏦ㄳ᭩࡟ᚑࡗ࡚ࢤࣀ࣒◊✲ศ㔝࡟ᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞
࠸ࠋఇᴗ᪥࣭฼⏝᫬㛫࣭᫬㛫እ฼⏝ձ ఇᴗ᪥ᅵ᭙ࠊ᪥᭙ࠊᅜẸࡢ⚃᪥࡟㛵ࡍࡿἲᚊ࡛つᐃࡉࢀࡓఇ᪥ࠊ ᭶  ᪥࠿ࡽ⩣ᖺ  ᭶  ᪥ࡲ࡛ࢆࢤࣀ
࣒ศ㔝ࡢఇᴗ᪥࡜ࡍࡿࠋࡓࡔࡋࠊศ㔝㛗ࡀᚲせ࡜ㄆࡵࡿሙྜࠊ⮫᫬࡟ఇᴗ᪥ࢆኚ᭦ࡋࠊཪࡣᐃࡵࡿ
ࡇ࡜ࡀࡁࡿࡇ࡜࡜ࡍࡿࠋղ ᖹ᪥฼⏝᫬㛫ᖹ᪥ ఇᴗ᪥௨እࡢ᪥ ࡢ฼⏝᫬㛫ࡣࠊ ᫬࠿ࡽ  ᫬ࡲ࡛࡜ࡍࡿࠋࡓࡔࡋࠊศ㔝㛗ࡀᚲせ࡜ㄆࡵࡿሙ
ྜࡣ฼⏝᫬㛫ࢆኚ᭦࡛ࡁࡿࡇ࡜࡜ࡍࡿࠋճ ᫬㛫እ฼⏝ᖹ᪥ࡢ฼⏝᫬㛫እ  ᫬㹼⩣ᮅ  ᫬ ࡟ࢤࣀ࣒ศ㔝࡛సᴗࢆ⾜࠺ሙྜࠊ฼⏝⪅ࡣཎ๎࡜ࡋ࡚ヱᙜ᪥ࡢ ᫬ࡲ࡛࡟ࢤࣀ࣒◊✲ศ㔝࡜฼⏝㈐௵⪅ࡢ୧᪉࡬᫬㛫እ฼⏝㢪࠸ࢆᥦฟࡍࡿࡶࡢ࡜ࡍࡿࠋࡲࡓࠊఇ
ᴗ᪥࡟ࢤࣀ࣒ศ㔝࡛సᴗࢆ⾜࠺ሙྜࠊ฼⏝⪅ࡣཎ๎࡜ࡋ࡚฼⏝๓ᖹ᪥ࡢ  ᫬ࡲ࡛࡟ࢤࣀ࣒◊✲ศ㔝࡜฼⏝㈐௵⪅ࡢ୧᪉࡬᫬㛫እ฼⏝㢪࠸ࢆᥦฟࡋࠊ ฼⏝ᶵ✀࡟ࡘࡁ  ෇ࡢ㏣ຍᩱ㔠ࢆ㈇ᢸࡍࡿ
ࡶࡢ࡜ࡍࡿࠋ
ඹྠ฼⏝ᶵჾ࣭ཷクゎᯒࡢ฼⏝ձ ฼⏝ᩱู㡯ࡢᩱ㔠⾲࡟ᚑ࠺ࡶࡢ࡜ࡍࡿࠋղ ฼⏝ᡭ⥆ࡁ฼⏝⪅ࡣࠊࢤࣀ࣒◊✲ศ㔝ࡢ࣮࣒࣮࣍࣌ࢪ࡟࡚ヱᙜᶵჾࡢண⣙ᡭ⥆ࡁࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋ
ண⣙ࡣ  ࣨ᭶ඛࡢ᭶ᮎࡲ࡛ࢆ㝈ᗘ࡜ࡋࠊ㸯ᅇศࡢண⣙ࡣཎ๎࡜ࡋ࡚  ᫬㛫௨ෆ࡜ࡍࡿࠋ
ྠ୍ࢢ࣮ࣝࣉࡢ㐃᪥ண⣙ࡣཎ๎  ᪥ࡲ࡛࡜ࡋࠊ᭦࡟㐃᪥ࡢ౑⏝ࢆᕼᮃࡍࡿሙྜࡣࢤࣀ࣒◊✲ศ㔝࡟┦ㄯࡍࡿࡇ࡜࡜ࡍࡿࠋճ ᶵჾ୙ㄪ࣭ᦆയ
ᶵჾ࡟୙ㄪ࣭ᦆയࡀぢࡽࢀࡓሙྜࠊ฼⏝⪅ࡣ┤ࡕ࡟⟶⌮ᐊ࡟㐃⤡ࡍࡿࡇ࡜࡜ࡋࠊࡑࡢࡲࡲ౑⏝ࡋ࡚ࡣ࡞ࡽ࡞࠸ࠋ
฼⏝⪅ࡢ୙ὀព࡟ࡼࡗ࡚ᶵჾࢆ୙ㄪ࡟ࡋࡓࡾࠊᦆയࡋࡓሙྜࡢಟ⌮㈝ࡣ⤒㈝㈇ᢸ㈐௵⪅ࡀ㈇࠺ࡶࡢ࡜ࡍࡿࠋմ ᶵჾࡢ฼⏝グ㘓౑⏝グ㘓⡙ࡀタ⨨ࡉࢀ࡚࠸ࡿᶵჾࢆ฼⏝ࡋࡓሙྜࡣࠊ฼⏝⪅ࡣࡑࡢ㒔ᗘᚲせ஦㡯ࢆグධࡋ࡞ࡅࢀࡤ
࡞ࡽ࡞࠸ࠋ



ᐇ㦂ᐊ➼ࡢ฼⏝ձ ฼⏝ᩱู㡯ࡢᩱ㔠⾲࡟ᚑ࠺ࡶࡢ࡜ࡍࡿࠋղ ฼⏝ᡭ⥆ࡁ᳜≀⏝ࢢ࣮ࣟࢫ࢟ࣕࣅࢿࢵࢺࠊᐇ㦂ྎࠊᐇ⩦ᐊࠊ◊ಟࢭ࣑ࢼ࣮ᐊࠊ3 ࣞ࣋ࣝᐇ㦂ᐊࠊ᳜≀᱂ᇵᐊࠊ3ᐊࢆ฼⏝ࡋࡼ࠺࡜ࡍࡿሙྜࠊ฼⏝㈐௵⪅ࡣࡑࢀࡒࢀࡢ฼⏝⏦㎸᭩ ู⣬ᵝᘧ➨  ྕ㹼➨  ྕ ࡟ࡼࡾᡭ⥆ࡁࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋճ ฼⏝⤊஢ࠊ୰Ṇࡢ㝿ࡢཎ≧᚟ᖐ฼⏝ࢆ⤊஢ࡲࡓࡣ୰Ṇࡋࡓ࡜ࡁࠊ฼⏝㈐௵⪅ࡣࠊ㏿ࡸ࠿࡟ᐇ㦂ᐊ➼ࢆཎ≧࡟᚟ᖐࡍࡿ࡜ඹ࡟ࠊ⟶⌮ᐊ࡟ࡑࡢ᪨ࢆሗ࿌ࡋ࡚ࢤࣀ࣒◊✲ศ㔝࡟ࡼࡿ฼⏝⤊஢☜ㄆࢆཷࡅ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋմ ࢤࣀ࣒◊✲ศ㔝ෆࡢ㣧㣗ࢤࣀ࣒◊✲ศ㔝ෆ࡛ࡢ㣧㣗ࡣࠊᡤᐃࡢሙᡤ࡛⾜࠺ࡇ࡜࡜ࡍࡿࠋյ ࢦ࣑ࡢฎ⌮ᐇ㦂➼࡛ฟࡓࢦ࣑ࡣࠊ࡛ࡁࡿ㝈ࡾྛ⮬࡛ᣢࡕᖐࡿࡇ࡜࡜ࡍࡿࠋ

ᶵჾࡢ㈚ฟࡋ
ࢤࣀ࣒◊✲ศ㔝ᡤ᭷ࡢᑠᆺᶵჾࡢ㈚ฟࡋࢆᕼᮃࡍࡿሙྜࠊ฼⏝㈐௵⪅ࡣᙜศ㔝࡟┦ㄯࡢୖࠊᶵჾ㈚ฟ
ࡋ⏦㎸᭩ ู⣬ᵝᘧ➨  ྕ ࡟ࡼࡾᡭ⥆ࡁࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋ

ᶵჾࡢᣢ㎸ࡳձ ᶵჾࡢᦙධ
฼⏝⪅ࡀࢤࣀ࣒◊✲ศ㔝࡟ᣢࡕ㎸ࡴᶵჾࡣᚲせ᭱ᑠ㝈ࡢᑠᆺᶵჾ࡜ࡋࠊ኱ᆺᶵჾࢆᦙධࡋ࡚ࡣ࡞ࡽ
࡞࠸ࠋᑠᆺᶵჾࢆࢤࣀ࣒◊✲ศ㔝࡟ᦙධࡍࡿሙྜࠊ฼⏝㈐௵⪅ࡣᙜศ㔝࡟┦ㄯࡢୖࠊᑠᆺᶵჾᦙධ⏦㎸᭩ู⣬ᵝᘧ➨  ྕ ࡟ࡼࡾᡭ⥆ࡁࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋղ ᦙධࡋࡓᑠᆺᶵჾࡢᡤᒓ⾲♧ࠊ⥔ᣢ࣭⟶⌮ᦙධࡋࡓᑠᆺᶵჾ࡟ࡣ฼⏝㈐௵⪅ࡢẶྡࠊ㐃⤡ඛࢆ᫂グࡍࡿࡇ࡜࡜ࡋࠊࡑࡢ⥔ᣢ࣭⟶⌮ࡣࠊ฼⏝㈐௵⪅ࡀ⾜࠺ࡶࡢ࡜ࡍࡿࠋճ ᦙධࡋࡓᑠᆺᶵჾࡢᦙฟ
ᢎㄆᮇ㛫ࡀ‶஢ࡋࡓ࡜ࡁࠊ฼⏝㈐௵⪅ࡣᦙධࡋࡓᑠᆺᶵჾࢆ㏿ࡸ࠿࡟ᦙฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

ࢤࣀ࣒◊✲Ჷฟධࡾࡢ᪉ἲ
ࢤࣀ࣒◊✲Ჷཬࡧࢤࣀ࣒◊✲Ჷ 5, ᐇ㦂ᐊ࡬ࡢฟධࡾࡣࠊ฼⏝Ⓩ㘓⏦ㄳ᭩ࢆᥦฟࡋㄆドⓏ㘓ࢆ᏶஢ࡋࡓ⫋ဨド࣮࢝ࢻࠊᏛ⏕ド࣮࢝ࢻࠊࡲࡓࡣ )HOLFD ᘧ᪋タ฼⏝ドࢆ౑⏝ࡍࡿࡶࡢ࡜ࡍࡿࠋ

⥭ᛴ஦ែⓎ⏕ࡢ㝿ࡢᥐ⨨⥭ᛴ஦ែࡀⓎ⏕ࡋࡓሙྜࠊ฼⏝⪅ࡣྛ㒊ᒇ࡟⾲♧ࡋ࡚࠶ࡿ⥭ᛴ㑊㞴⤒㊰ࠊ࢞ࢫࡢඖᰦࡢሙᡤࠊ㟁※ࡢ
ሙᡤࢆཧ↷ࡋ࡚㐺ษ࡟ᑐฎࡍࡿࡇ࡜ࠋ
฼⏝ୖࡢၥ㢟Ⅼࡢฎ⌮฼⏝⪅ࡀࢤࣀ࣒◊✲ศ㔝ࡢ฼⏝࡛ၥ㢟ࢆឤࡌࡓሙྜࠊࢤࣀ࣒◊✲ศ㔝ࡢᩍဨࢆ㏻ࡌ࡚ศ㔝㛗࡟⏦ࡋฟࡿࡇ࡜࡜ࡍࡿࠋศ㔝㛗ࡣࠊᚲせ࡟ᛂࡌ࡚ࢭࣥࢱ࣮㛗࡟ሗ࿌ࡍࡿ࡜ඹ࡟㐠Ⴀጤဨ఍࡛ᑂ㆟ࡢୖࠊᨵၿࢆ
ᅗࡿࡶࡢ࡜ࡍࡿࠋ௧࿴  ᖺᗘάື≧ἣሗ࿌ㅮ⩦఍࣭ࢭ࣑ࢼ࣮➼‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦Ỉ㸧ࠥ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ᶵჾㅮ⩦఍ >ඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾 &DUO =HLVV/60@ ཧຍ⪅  ྡ‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦ⅆ㸧ࠥ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ᶵჾㅮ⩦఍ >ඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾 &DUO =HLVV/60 ⱥㄒ∧@ ཧຍ⪅  ྡ‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦Ỉ㸧ࠥ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ࣂ࢖࢜ࢺࣞࣥࢻࢭ࣑ࢼ࣮
>㑇ఏᏊ㓄ิゎᯒࢯࣇࢺ &/&*HQRPLFV:RUNEHQFK@ ཧຍ⪅  ྡ‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦Ỉ㸧ࠥ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ࣂ࢖࢜ࢺࣞࣥࢻࢭ࣑ࢼ࣮
>ࢹࢪࢱࣝ 3&5@ཧຍ⪅  ྡ‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦ᅵ㸧㹼
>୰Ꮫ⏕ࡢࡓࡵࡢ⏕࿨⛉Ꮫయ㦂ࣉࣟࢢ࣒ࣛࠕྩ࡟ࡶ࡛ࡁࡿ '1$ 㚷ᐃࠖ@ཧຍ⪅  ྡ‫ ی‬௧࿴ᖺ᭶᪥㸦ᅵ㸧㹼ࠊ᪥㸦᪥㸧㹼
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㡲㈡ ᬕஂ㸦/6㸧㹎㸯 ᐊΎỈ ᑗᩥ㸦$*㸧㸦㸧௧࿴  ᖺᗘᴗ⦼ㄽᩥ➼ED-03[1] ґ౽

‫ݲ‬ʀ๼ଞ५Ҳʀ໼޳྆ଢʀௗଢ৵হʀ‫ݻ‬Բ߃ଉʤ2021ʥʁࢀ॑‫ݟ‬๼੐ஏҮͶ͕͜Ζࠅ಼֐པνϑϧ Acheilognathus tabira ྪ͹֮೟ͳҪఽదಝ௅.‫ࢿࡸָྪڗ‬ɾ68, 47–52.
[2] ‫ٳ‬ฯಲᏽʀґ౽ ‫ݲ‬ʀ໼޳྆ଢʀ๼ଞ५Ҳʀ‫ݻ‬Բ߃ଉʤ2021ʥʁࢀ॑‫ݟ‬Յໞઔਭ‫ܧ‬Ͷ͕͜ΖΏΕνψβ Tanakia lanceolata ͹ॵ‫ى‬࿧ɿਫ਼෼ஏཀྵָճճๅɾ76, 70–74.
RS-02[3] Maeda K., Kobayashi H., Palla H.P., Shinzato C., Koyanagi R., Montenegro J., Nagano A.J., Saeki T.,
Kunishima T., Mukai T., Tachihara K., Laudet V., Satoh N., Yamahira K. (2021) ,Do colour-morphs of anamphidromous goby represent different species? Taxonomy of Lentipes (Gobiiformes) from Japan and
Palawan, Philippines, with phylogenomic approaches, Systematics and Biodiversity 19 1080-1112[4] ஝಼߅ଢʀҬ৏ิࣰʀ‫ీݻ‬Ꮾथʀ߶໨կ‫ن‬ʀ޴Ҭ‫ي‬ඛ (2021) ࿪Րࢃ‫Ͳݟ‬൅‫͠ݡ‬ΗͪΠϩϑό͹
ιφΤογϱεϥΤΤΨ.ᗣமྈਖ਼ྪָճๅ, 2021: 189-191.
[5] ޴Ҭ‫ي‬ඛʀਁ෨҂࢜ʀ೉ీఫ࢞ʀీ৏ਜ਼ཾ (2021) ‫ز‬෠‫ݟ‬͹ಊ෼ ᄣ೗ྪʀᗣமྪʀྈਫ਼ྪʀॉ‫ٯ‬ྪɿ‫ز‬෠৿ซऀɾ268ppɿ
MD-06[6] Tomita H., Tanaka K., Hirata A., Okada H., Imai H., Shirakami Y., Ohnishi K., Sugie S., Aoki H., Hatano
Y., Noguchi K., Kanayama T., Niwa A., Suzui N., Miyazaki T., Tanaka T., Akiyama H., Shimizu M.,
Yoshida K., Hara A. (2021) ,Inhibition of FGF10-ERK signal activation suppresses intraductal papillary
neoplasm of the bile duct and its associated carcinomas, Cell Reports 34 108772[7] Enomoto T., Nakane K., Tomioka M., Nakai C., Kawase K., Kato D., Takai M., Iinuma K., Mizutani K.,
Tsuchiya T., Moriyama Y., Miwa K., Hatano Y., Miyazaki T., Koie T. (2021) ,Paraurethral Leiomyoma ina Female Patient who Had Clinical Symptoms with Increase of Tumor Volume: A Case Report, Hinyokika
kiyo. Acta urologica Japonica 67 339-342

[8] Tomioka M., Hishida S., Enomoto T., Kawase K., Nakai C., Kato D., Takai M., Iinuma K., Nakane K.,
Mizutani K., Tsuchiya T., Hatano Y., Miyazaki T., Goto T., Koie T. (2021) ,RENAL CELL CARCINOMA
in the LEFT PELVIC KIDNEY: A CASE REPORT, Acta Urologica Japonica 67 153-156[9] Kinoshita T., Tomita H., Okada H., Niwa A., Hyodo F., Kanayama T., Matsuo M., Imaizumi Y., Kuroda
T., Hatano Y., Miyai M., Egashira Y., Enomoto Y., Nakayama N., Sugie S., Matsumoto K., YamaguchiY., Matsuo M., Hara H., Iwama T., Hara A. (2021) ,Endothelial cell-specific reduction of heparan sulfate
suppresses glioma growth in mice, Discover Oncology 12 50[10] Hatano Y., Ideta T., Hirata A., Hatano K., Tomita H., Okada H., Shimizu M., Tanaka T., Hara A.
(2021) ,Virus-driven carcinogenesis, Cancers 13 2625
[11] Kanayama T., Taniguchi T., Tomita H., Niwa A., Noguchi K., Matsuo M., Imaizumi Y., Kuroda T., Hatano
Y., Okazaki I., Kato T., Hara A. (2021) ,Aldh1 and sall4 expression in cell block samples from patientswith lung adenocarcinoma and malignant pleural effusion, Diagnostics 11 1463
[12] Hatano Y., Tamada M., Shiga T., Niwa A., Kanayama T., Noguchi K., Morishige K.-I., Tomita H., Hara
A. (2021) ,Clinically relevant umbilical cord inflammation identified based on CD15-associated vasculitis
patterning, Placenta 108 39-46[13] Kawaguchi M., Kato H., Hatano Y., Tomita H., Hara A., Miyazaki T., Matsuo M. (2021) ,Magnetic
resonance imaging findings of extrauterine high-grade serous carcinoma based on new pathologic criteria
for primary site assignment, Acta Radiologica 62 687-694[14] Miyai M, Kanayama T, Hyodo F, Kinoshita T, Ishihara T, Okada H, Suzuki H, Takashima S, Wu Z, Hatano
Y, Egashira Y, Enomoto Y, Nakayama N, Soeda A, Yano H, Hirata A, Niwa M, Sugie S, Mori T, Maekawa
Y, Iwama T, Matsuo M, Hara A, Tomita H. (2021) ,Glucose transporter Glut1 controls diffuse invasion
phenotype with perineuronal satellitosis in diffuse glioma microenvironment, Neurooncol Adv. 2020 Oct
30;3(1):vdaa150
MD-08[15] Tanaka S., Abe C., Abbott S.B.G., Zheng S., Yamaoka Y., Lipsey J.E., Skrypnyk N.I., Yao J., Inoue T.,
Nash W.T., Stornetta D.S., Rosin D.L., Stornetta R.L., Guyenet P.G., Okusa M.D. (2021) ,Vagus nerve
stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice fromkidney injury, Proceedings of the National Academy of Sciences of the United States of America 118
e2021758118[16] Aoki H., Abe C., Hara A., Miyazaki T., Morita H., Kunisada T. (2021) ,Induced genetic ablation of Rest
leads to the alteration of stimulus-induced response of the vagal nerve, Genes to Cells 26 45-55

MD-09[17] Kimura A., Kato S., Takekoshi A., Yoshikura N., Yanagida N., Kitaguchi H., Akiyama D., Shimizu H.,
Kakita A., Shimohata T. (2021) ,Autoimmune glial fibrillary acidic protein astrocytopathy resembling
isolated central nervous system lymphomatoid granulomatosis, Journal of Neuroimmunology 361 577748[18] Nakamura S., Fujioka T., Kawashima S., Kawaguchi T., Mizuno M., Omura M., Okita K., Kimura A.,
Shimohata T., Matsukawa N. (2021) ,Self-remitting Elevation of Adenosine Deaminase Levels in the
Cerebrospinal Fluid with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report andReview of the Literature, Internal Medicine 60 3031-3036[19] Adachi H., Shiomi Y., Kimura A., Shimohata T., Yoneda Y., Kageyama Y. (2021) ,A case of autoimmune
glial fibrillary acidic protein (GFAP) astrocytopathy [ࣙ‫ހ‬໖Ӻ੓ glial fibrillary acidic proteinʤGFAPʥΠηφϫγ΢φϏοʖ͹ 1 ྭ], Clinical Neurology 61 401-404
MD-11[20] Shimamori Y., Pramono A.K., Kitao T., Suzuki T., Aizawa S.-I., Kubori T., Nagai H., Takeda S., Ando H.
(2021) ,Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical
Isolates from Patients with Atopic Dermatitis, Current Microbiology 78 1267-1276
MD-19[21] Takeuchi K., Ogawa H., Kuramitsu N., Akaike K., Goto A., Aoki H., Lassar A., Suehara Y., Hara A.,
Matsumoto K., Akiyama H. (2021) ,Colchicine protects against cartilage degeneration by inhibiting
MMP13 expression via PLC-ȖSKRVSKRU\ODWLRQ2VWHRDUWKULWLVDQG&DUWLODJH-1574
MD-20[22] Nishihira J., Nishimura M., Kurimoto M., Kagami-Katsuyama H., Hattori H., Nakagawa T., Muro T.,
Kobori M. (2021) ,The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive
decline in healthy elderly people: A randomized, double-blind, placebo-controlled, parallel-groupcomparative clinical trial, Journal of Clinical Biochemistry and Nutrition 69 203-215
MD-22[23] Muramatsu-Maekawa Y., Kawakami K., Fujita Y., Takai M., Kato D., Nakane K., Kato T., Tsuchiya T.,
Koie T., Miura Y., Ito M., Mizutani K. (2021) ,Profiling of serum extracellular vesicles reveals miRNA4525 as a potential biomarker for advanced renal cell carcinoma, Cancer Genomics and Proteomics 18 253259[24] Kawakami K., Fujita Y., Kato T., Horie K., Koie T., Umezawa K., Tsumoto H., Miura Y., Katagiri Y.,
Miyazaki T., Ohsawa I., Mizutani K., Ito M. (2021) ,Diagnostic potential of serum extracellular vesicles
expressing prostate-specific membrane antigen in urologic malignancies, Scientific Reports 11 15000

[25] Takai M., Kawakami K., Fujita Y., Kato T., Kato D., Iinuma K., Koie T., Ito M., Mizutani K.
(2021) ,Kartogenin inhibits prostate cancer cell growth through Smad2 activation and decreases androgen
receptor nuclear localization, Anticancer Research 41 4753-4759[26] Hishida S., Kawakami K., Fujita Y., Kato T., Takai M., Iinuma K., Nakane K., Tsuchiya T., Koie T., MiuraY., Ito M., Mizutani K. (2021) ,Proteomic analysis of extracellular vesicles identified PI3K pathway as apotential therapeutic target for cabazitaxel-resistant prostate cancer, Prostate 81 592-602[27] Iinuma K., Kawakami K., Mizutani K., Fujita Y., Yamaguchi T., Ito M., Kumano T., Matsuo M., Nakano
M., Koie T., Ito M., Kato T. (2021) ,MiRNA-93 in serum extracellular vesicles before and after low dose
rate prostate brachytherapy, Anticancer Research 41 2411-2418
MD-41[28] Le Coz M., Aktary Z., Watanabe N., Yajima I., Pouteaux M., Charoenchon N., Motohashi T., Kunisada T.,&RUYHOR$/DUXH/  7DUJHWHG.QRFNRXWRIȕ-Catenin in Adult Melanocyte Stem Cells Using a
Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects, Journalof Investigative Dermatology 141 1363-1366.e9.
MD-45[29] Takahashi T., Shiraishi A., Murata J., Matsubara S., Nakaoka S., Kirimoto S., Osawa M.
(2021) ,Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B
signaling, Life Science Alliance 4 e202000962
MD-46[30] Saigo C., Kito Y., Hasegawa M., Nomura S., Mikamo T., Hanamatsu Y., Mori R., Futamura M., YoshidaK., Takeuchi T. (2021) ,Incidental cytokeratin-positive interstitial reticulum cell tumor of the lymph nodeaccompanied by breast cancer: Status of YAP/TAZ expression in tumor cells, Human Pathology: Case
Reports 25 200526[31] Tanaka H., Saigo C., Iwata Y., Yasufuku I., Kito Y., Yoshida K., Takeuchi T. (2021) ,Human colorectal
cancer-associated carbohydrate antigen on annexin A2 protein, Journal of Molecular Medicine 99 11151123[32] Yasufuku I., Saigo C., Kito Y., Yoshida K., Takeuchi T. (2021) ,Prognostic significance of LDL receptorrelated protein 1B in patients with gastric cancer, Journal of Molecular Histology 52 165-172[33] Sakuratani T., Takeuchi T., Yasufuku I., Iwata Y., Saigo C., Kito Y., Yoshida K. (2021) ,Downregulationof ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakirimediated apoptosis pathway, Virchows Archiv 478 401-411[34] Iwata Y., Yasufuku I., Saigo C., Kito Y., Takeuchi T., Yoshida K. (2021) ,Anti-fibrotic properties of an
adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma,
Journal of Cancer 12 1161-1168

[35] Kawashima K., Kito Y., Tochii K., Kimura M., Takeda T., Sekino T., Ikeda T., Takeuchi T. (2021) ,A
unique case of splenic tumor exhibiting a serous carcinoma phenotype, SAGE Open Medical Case Reports
9MD-56[36] Hatakeyama S., Tojo A., Satonaka H., Yamada N.O., Senda T., Ishimitsu T. (2021) ,Decreased podocyte
vesicle transcytosis and albuminuria in apc c-terminal deficiency mice with puromycin-induced nephrotic
syndrome, International Journal of Molecular Sciences 22 13412[37] Yamada N.O., Senda T. (2021) ,Correction to: Circulating microRNA-92a-3p in colorectal cancer: a review(Medical Molecular Morphology, ('(2021)), 54, 3, (193-202), 10.1007/s00795-021-00282-w), Medical
Molecular Morphology 54 302-303[38] Yamada N.O., Senda T. (2021) ,Circulating microRNA-92a-3p in colorectal cancer: a review, Medical
Molecular Morphology 54 193-202[39] Wenduerma, Yamada N.O., Wang T., Senda T. (2021) ,A further study on a disturbance of intestinal
epithelial cell population and kinetics in APC1638T mice, Medical Molecular Morphology 54 203-215[40] Li C., Onouchi T., Hirayama M., Sakai K., Matsuda S., Yamada N.O., Senda T. (2021) ,Morphologicaland functional abnormalities of hippocampus in APC 1638T/1638T mice, Medical Molecular Morphology
54 31-40
MD-57[41] Tokumaru Y., Oshi M., Huyser M.R., Yan L., Fukada M., Matsuhashi N., Futamura M., Akao Y., YoshidaK., Takabe K. (2021) ,Low expression of miR-29a is associated with aggressive biology and worse survival
in gastric cancer, Scientific Reports 11 14134[42] Nonaka K., Saio M., Umemura N., Kikuchi A., Takahashi T., Osada S., Yoshida K. (2021) ,Th1
polarization in the tumor microenvironment upregulates the myeloid-derived suppressor-like function ofmacrophages, Cellular Immunology 369 104437[43] Tsuburaya A., Guan J., Yoshida K., Kobayashi M., Yoshino S., Tanabe K., Yoshikawa T., Oshima T.,
Miyashita Y., Sakamoto J., Tanaka S. (2021) ,Clinical biomarkers in adjuvant chemotherapy for gastriccancer after D2 dissection by a pooled analysis of individual patient data from large randomized controlled
trials, Gastric Cancer 24 1184-1193[44] Fukada M., Matsuhashi N., Takahashi T., Sugito N., Heishima K., Yoshida K., Akao Y.
(2021) ,Postoperative changes in plasma miR21-5p as a novel biomarker for colorectal cancer recurrence:
A prospective study, Cancer Science 112 4270-4280[45] Suetsugu T., Mori R., Futamura M., Fukada M., Tanaka H., Yasufuku I., Sato Y., Iwata Y., Imai T., Imai
H., Tanaka Y., Okumura N., Matsuhashi N., Takahashi T., Yoshida K. (2021) ,Mechanism of acquired5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer
cell lines, Oncology Reports 45 27[46] Tokumaru Y., Oshi M., Patel A., Tian W., Yan L., Matsuhashi N., Futamura M., Yoshida K., Takabe K.
(2021) ,Organoids are limited in modeling the colon adenoma– carcinoma sequence, Cells 10 1-15
[47] Le L., Tokumaru Y., Oshi M., Asaoka M., Yan L., Endo I., Ishikawa T., Futamura M., Yoshida K., Takabe
K. (2021) ,Th2 cell infiltrations predict neoadjuvant chemotherapy response of estrogen receptor-positive
breast cancer, Gland Surgery 10 154-165[48] Kato T., Matsuhashi N., Tomita H., Takahashi T., Iwata Y., Fukada M., Yasufuku I., Suetsugu T., Imai T.,
Mori R., Imai H., Tanaka Y., Okumura N., Hara A., Yoshida K. (2021) ,MYC Up-regulation is a usefulbiomarker for preoperative neoadjuvant chemotherapy combined with anti-EGFR in liver metastasis fromcolorectal cancer, In Vivo 35 203-213[49] Tomita H., Tanaka K., Hirata A., Okada H., Imai H., Shirakami Y., Ohnishi K., Sugie S., Aoki H., Hatano
Y., Noguchi K., Kanayama T., Niwa A., Suzui N., Miyazaki T., Tanaka T., Akiyama H., Shimizu M.,
Yoshida K., Hara A. (2021) ,Inhibition of FGF10-ERK signal activation suppresses intraductal papillary
neoplasm of the bile duct and its associated carcinomas, Cell Reports 34 108772[50] Yasufuku I., Saigo C., Kito Y., Yoshida K., Takeuchi T. (2021) ,Prognostic significance of LDL receptorrelated protein 1B in patients with gastric cancer, Journal of Molecular Histology 52 165-172[51] Sakuratani T., Takeuchi T., Yasufuku I., Iwata Y., Saigo C., Kito Y., Yoshida K. (2021) ,Downregulationof ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakirimediated apoptosis pathway, Virchows Archiv 478 401-411[52] Iwata Y., Yasufuku I., Saigo C., Kito Y., Takeuchi T., Yoshida K. (2021) ,Anti-fibrotic properties of an
adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma,
Journal of Cancer 12 1161-1168
MD-60[53] Sampei S., Okada H., Tomita H., Takada C., Suzuki K., Kinoshita T., Kobayashi R., Fukuda H., Kawasaki
Y., Nishio A., Yano H., Muraki I., Fukuda Y., Suzuki K., Miyazaki N., Watanabe T., Doi T., Yoshida T.,
Suzuki A., Yoshida S., Kushimoto S., Ogura S. (2021) ,Endothelial Glycocalyx Disorders May Be
Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model, Frontiers in
Cell and Developmental Biology 9 623582[54] Sampei S., Okada H., Tomita H., Suzuki A., Nawa T., Ogura S. (2021) ,Point of tangency between
coronavirus disease and endothelial injury, International Journal of Emergency Medicine 14 76[55] Yamada N., Kitagawa Y., Yoshida T., Nachi S., Okada H., Ogura S. (2021) ,Validity and risk factor
analysis for helicopter emergency medical services in Japan: a pilot study, BMC Emergency Medicine 2187[56] Matsubara T., Umemura Y., Ogura H., Matsuura H., Ebihara T., Matsumoto H., Yamakawa K., Shimizu
K., Okada H., Shimazu T. (2021) ,Bone Marrow-Derived Mononuclear Cell Transplantation Can Reduce
Systemic Inflammation and Endothelial Glycocalyx Damage in Sepsis, Shock (Augusta, Ga.) 56 260-267[57] Kamidani R., Okada H., Kato R., Nishihori T., Kuze B., Yoshida T., Yoshida S., Ogura S. (2021) ,Open
penetrating external laryngotracheal injury and abdominal trauma by suicide attempt successfully treatedwith immediate intervention: A case report, Trauma Case Reports 32 100435[58] Okada H., Yoshida S., Hara A., Ogura S., Tomita H. (2021) ,Vascular endothelial injury exacerbates
coronavirus disease 2019: The role of endothelial glycocalyx protection, Microcirculation 28 e12654[59] Kusuzawa K., Suzuki K., Okada H., Suzuki K., Takada C., Nagaya S., Yasuda R., Okamoto H., IshiharaT., Tomita H., Kawasaki Y., Minamiyama T., Nishio A., Fukuda H., Shimada T., Tamaoki Y., Yoshida T.,
Nakashima Y., Chiba N., Yoshimura G., Kamidani R., Miura T., Oiwa H., Yamaji F., Mizuno Y., Miyake
T., Kitagawa Y., Fukuta T., Doi T., Suzuki A., Yoshida T., Tetsuka N., Yoshida S., Ogura S.
(2021) ,Measuring the Concentration of Serum Syndecan-1 to Assess Vascular Endothelial Glycocalyx
Injury During Hemodialysis, Frontiers in Medicine 8 791309[60] Kitagawa Y., Kawamura I., Suzuki K., Okada H., Ishihara T., Tomita H., Suzuki K., Takada C., Sampei
S., Kano S., Kondo K., Asano H., Wakayama Y., Kamidani R., Kawasaki Y., Fukuda H., Nishio A., Miyake
T., Fukuta T., Yasuda R., Oiwa H., Kakino Y., Miyazaki N., Watanabe T., Yoshida T., Doi T., Suzuki A.,
Yoshida S., Matsuo H., Ogura S. (2021) ,Serum syndecan-1 concentration in hospitalized patients withheart failure may predict readmission-free survival, PLoS ONE 16 e0260350[61] Kamidani R., Miyake T., Okada H., Yoshimura G., Kusuzawa K., Miura T., Shimaoka R., Oiwa H., Yamaji
F., Mizuno Y., Yasuda R., Kitagawa Y., Fukuta T., Ishihara T., Shiga T., Okamoto H., Tachi M., Shiba M.,
Kanda N., Nachi S., Doi T., Yoshida T., Yoshida S., Morishige K., Ogura S. (2021) ,Effect of
cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study,
Scientific Reports 11 18458[62] Kamidani R., Kumada K., Okada H., Yoshimura G., Kanayama T., Tomita H., Miura T., Oiwa H., Mizuno
Y., Kitagawa Y., Yasuda R., Fukuta T., Miyake T., Doi T., Yoshida T., Yoshida S., Hara A., Ogura S.
(2021) ,Postmortem diagnosis of pulmonary tumor thrombotic microangiopathy with rapid exacerbation ina patient with gastric cancer: a case report, International Journal of Emergency Medicine 14 53[63] Suzuki K., Okada H., Sumi K., Tomita H., Kobayashi R., Ishihara T., Kakino Y., Suzuki K., YoshiyamaN., Yasuda R., Kitagawa Y., Fukuta T., Miyake T., Okamoto H., Doi T., Yoshida T., Yoshida S., Ogura
S., Suzuki A. (2021) ,Serum syndecan-1 reflects organ dysfunction in critically ill patients, Scientific
Reports 11 8864

[64] Suzuki K., Okada H., Tomita H., Sumi K., Kakino Y., Yasuda R., Kitagawa Y., Fukuta T., Miyake T.,
Yoshida S., Suzuki A., Ogura S. (2021) ,Possible involvement of Syndecan-1 in the state of COVID-19
related to endothelial injury, Thrombosis Journal 19 5[65] Kamidani R., Okada H., Kitagawa Y., Kusuzawa K., Ichihashi M., Kakino Y., Oiwa H., Yasuda R., Fukuta
T., Yoshiyama N., Miyake T., Okamoto H., Suzuki K., Yamada N., Doi T., Yoshida T., Ushikoshi H.,
Kumada K., Yoshida S., Ogura S. (2021) ,Severe heat stroke complicated by multiple cerebral infarctions:a case report, Journal of Medical Case Reports 15 24[66] Okamoto H., Muraki I., Okada H., Tomita H., Suzuki K., Takada C., Wakayama Y., Kuroda A., Fukuda
H., Kawasaki Y., Nishio A., Matsuo M., Tamaoki Y., Inagawa R., Takashima S., Taniguchi T., Suzuki A.,
Suzuki K., Miyazaki N., Kakino Y., Yasuda R., Fukuta T., Kitagawa Y., Miyake T., Doi T., Yoshida T.,
Yoshida S., Ogura S. (2021) ,Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome
in Experimental Endotoxemia, American Journal of Pathology 191 1526-1536[67] Tomita H., Tanaka K., Hirata A., Okada H., Imai H., Shirakami Y., Ohnishi K., Sugie S., Aoki H., Hatano
Y., Noguchi K., Kanayama T., Niwa A., Suzui N., Miyazaki T., Tanaka T., Akiyama H., Shimizu M.,
Yoshida K., Hara A. (2021) ,Inhibition of FGF10-ERK signal activation suppresses intraductal papillary
neoplasm of the bile duct and its associated carcinomas, Cell Reports 34 108772[68] Kinoshita T., Tomita H., Okada H., Niwa A., Hyodo F., Kanayama T., Matsuo M., Imaizumi Y., Kuroda
T., Hatano Y., Miyai M., Egashira Y., Enomoto Y., Nakayama N., Sugie S., Matsumoto K., YamaguchiY., Matsuo M., Hara H., Iwama T., Hara A. (2021) ,Endothelial cell-specific reduction of heparan sulfate
suppresses glioma growth in mice, Discover Oncology 12 50[69] Hatano Y., Ideta T., Hirata A., Hatano K., Tomita H., Okada H., Shimizu M., Tanaka T., Hara A.
(2021) ,Virus-driven carcinogenesis, Cancers 13 2625
MD-62[70] Shoda K., Enomoto Y., Egashira Y., Kinoshita T., Mizutani D., Iwama T. (2021) ,Long-term complications
after stent assist coiling dependent on clopidogrel response, BMC Neurology 21 247[71] Kinoshita T., Tomita H., Okada H., Niwa A., Hyodo F., Kanayama T., Matsuo M., Imaizumi Y., Kuroda
T., Hatano Y., Miyai M., Egashira Y., Enomoto Y., Nakayama N., Sugie S., Matsumoto K., YamaguchiY., Matsuo M., Hara H., Iwama T., Hara A. (2021) ,Endothelial cell-specific reduction of heparan sulfate
suppresses glioma growth in mice, Discover Oncology 12 50[72] Sampei S., Okada H., Tomita H., Takada C., Suzuki K., Kinoshita T., Kobayashi R., Fukuda H., Kawasaki
Y., Nishio A., Yano H., Muraki I., Fukuda Y., Suzuki K., Miyazaki N., Watanabe T., Doi T., Yoshida T.,
Suzuki A., Yoshida S., Kushimoto S., Ogura S. (2021) ,Endothelial Glycocalyx Disorders May Be
Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model, Frontiers in
Cell and Developmental Biology 9 623582

MD-63[73] Kitao T., Arasaki K., Nagai H., Kubori T. (2021) ,Protocol for imaging proteins associated with Legionellacontaining vacuoles in host cells, STAR Protocols 2 100410[74] Shimamori Y., Pramono A.K., Kitao T., Suzuki T., Aizawa S.-I., Kubori T., Nagai H., Takeda S., Ando H.
(2021) ,Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical
Isolates from Patients with Atopic Dermatitis, Current Microbiology 78 1267-1276[75] Kawabata M., Matsuo H., Koito T., Murata M., Kubori T., Nagai H., Tagaya M., Arasaki K.
(2021) ,Legionella hijacks the host Golgi-to-ER retrograde pathway for the association of Legionellacontaining vacuole with the ER, PLoS Pathogens 17 e1009437[76] Shimamori Y., Mitsunaka S., Yamashita H., Suzuki T., Kitao T., Kubori T., Nagai H., Takeda S., Ando H.
(2021) ,Staphylococcal phage in combination with staphylococcus epidermidis as a potential treatment forstaphylococcus aureus-associated atopic dermatitis and suppressor of phage-resistant mutants, Viruses 137[77] ๼ඎޮӵɼ‫ٳ‬ຉஒࢢɼӮҬ޼ध

(2021)

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ঘ๖༎ૻεητϞ͹૤ࡠ Journal of Japanese Biochemical Society 93(6): 835-839
EG-02[78] Tahara N., Tachibana I., Takeo K., Yamashita S., Shimada A., Hashimoto M., Ohno S., Yokogawa T.,
Nakagawa T., Suzuki F., Ebihara A. (2021) ,Boosting Auto-Induction of Recombinant Proteins inEscherichia coli with Glucose and Lactose Additives, Protein and peptide letters 28 1180-1190
EG-03[79] Sai M. (2021) ,A Tetraarylpyrrole-Based Phosphine Ligand for the Palladium-Catalyzed Amination of Aryl
Chlorides, Advanced Synthesis and Catalysis 363 5422-5428[80] Sai M. (2021) ,Potassium Base-Promoted Diastereoselective Synthesis of 1,3-Diols from Allylic Alcohols
and Aldehydes through a Tandem Allylic-Isomerization/Aldol–Tishchenko Reaction, Chemistry - An
Asian Journal 16 4053-4056[81] Sai M., Kurouchi H. (2021) ,Potassium Base-&DWDO\]HG 0LFKDHO $GGLWLRQV RI $OO\OLF $OFRKROV WR ĮȕUnsaturated Amides: Scope and Mechanistic Insights, Advanced Synthesis and Catalysis 363 3585-3591
EG-05[82] Kubota Y., Nakazawa M., Lee J., Naoi R., Tachikawa M., Inuzuka T., Funabiki K., Matsui M., Kim T.
(2021) ,Synthesis of near-infrared absorbing and fluorescent bis(pyrrol-2-yl)squaraines and their
halochromic properties, Organic Chemistry Frontiers 8 6226-6243[83] Funabiki K., Yamada K., Matsueda H., Arisawa Y., Agou T., Kubota Y., Inuzuka T., Wasada H.
(2021),Perfluorophenyl-Perfluorophenyl

Stacking-Promoted



Aggregation-Induced

EmissionEnhancement of Crystalline 5-Aryloxy-3H-Indole, European Journal of Organic Chemistry 2021 13441350[84] Funabiki K., Gotoh T., Kani R., Inuzuka T., Kubota Y. (2021) ,Highly diastereo- And enantioselective
organocatalytic synthesis of trifluoromethylated erythritols based on thein situgeneration of unstable
trifluoroacetaldehyde, Organic and Biomolecular Chemistry 19 1296-1304
EG-07[85] Shirakami N., Kawaki Y., Higashi S.L., Shibata A., Kitamura Y., Hanifah S.A., Wah L.L., Ikeda M.
(2021) ,Introduction of an Oxidation-responsive 4-Boronobenzyl Group into an Oligonucleotide through a
Postmodification Approach, Chemistry Letters 50 1412-1415[86] Shirakami N., Higashi S.L., Kawaki Y., Kitamura Y., Shibata A., Ikeda M. (2021) ,Construction of areduction-responsive oligonucleotide via a post-modification approach utilizing 4-nitrophenyl
diazomethane, Polymer Journal 53 741-746[87] Ohtomi T., Higashi S.L., Mori D., Shibata A., Kitamura Y., Ikeda M. (2021) ,Effect of side chain phenylgroup on the self-assembled morphology of dipeptide hydrazides, Peptide Science 113 e24200
EG-08[88] Fukawa Y., Mizuno Y., Kawade K., Mitsukura K., Yoshida T. (2021) ,Novel (S)-selective hydrolase fromarthrobacter sp. k5 for kinetic resolution of cyclic amines, Catalysts 11 809
EG-09[89] Heishima K., Sugito N., Soga T., Nishikawa M., Ito Y., Honda R., Kuranaga Y., Sakai H., Ito R., Nakagawa
T., Ueda H., Akao Y. (2021) ,Petasin potently inhibits mitochondrial complex I–based metabolism that
supports tumor growth and metastasis, Journal of Clinical Investigation 131 e139933[90] Nomura T.K., Heishima K., Sugito N., Sugawara R., Ueda H., Yukihiro A., Honda R. (2021) ,Specificinhibition of oncogenic RAS using cell-permeable RAS-binding domains, Cell Chemical Biology 28 15811589 e6EG-15[91] Sonawane A.D., Sonawane R.A., Ninomiya M., Koketsu M. (2021) ,Diorganyl diselenides: A powerfultool for the construction of selenium containing scaffolds, Dalton Transactions 50 12764-12790[92] Itoh T., Fujita S., Koketsu M., Hashizume T. (2021) ,Citrulluside H and citrulluside T from youngwatermelon fruit attenuate ultraviolet B radiation-induced matrix metalloproteinase expression through thescavenging of generated reactive oxygen species in human dermal fibroblasts, Photodermatology
Photoimmunology and Photomedicine 37 386-394[93] Ukiya M., Motegi K., Sato D., Kimura H., Satsu H., Koketsu M., Ninomiya M., Myint L.M., Nishina A.
(2021) ,Effect of Compounds from Moringa oleifera Lam. on in Vitro Non-Alcoholic Fatty Liver Disease(NAFLD) Model System, Chemistry and Biodiversity 18 e2100243

[94] Win

K.M.N.,

Sonawane

A.D.,

KoketsuM.

(2021),Synthesisofselenated

tetracyclic

indoloazulenesviaiodine and diorganyl diselenides, Organic and Biomolecular Chemistry 19 3199-3206[95] Mandela J., Trisunaryanti W., Triyono, Koketsu M., Fatmawati D.A. (2021) ,Hydrochloric acid and/or
sodium hydroxide-modified zeolite y for catalytic hydrotrHDWLQJRIĮ-cellulose bio-oil, Indonesian Journalof Chemistry 21 787-796[96] Sonawane A.D., Koketsu M. (2021) ,Organocatalysed synthesis of selenium containing scaffolds, Current
Organocatalysis 8 5-26
EG-17[97] Oka N., Hirabayashi H., Kumada K., Ando K. (2021) ,Synthesis of xanthosine 2-phosphate diesters via
phosphitylation of the carbonyl group, Bioorganic and Medicinal Chemistry Letters 54 128439[98] Oka N., Kanda M., Furuzawa M., Arai W., Ando K. (2021) ,Serendipitous One-Step Synthesis of
Cyclopentene DerivativeVIURP ƍ-Deoxy-ƍ-heteroarylsulfonylnucleosides as Nucleoside-Derived JuliaKocienski Reagents, Journal of Organic Chemistry 86 16684-16698[99] Oka N., Suzuki K., Mori A., Ando K. (2021) ,Stereoselective Synthesis of 1,2-cis-Glycosyl Sulfones andTheir Application in One-Pot Julia Olefination for the Synthesis of exo-Glycals, European Journal of
Organic Chemistry 2021 5922-5933[100]

Oka N., Mori A., Suzuki K., Ando K. (2021) ,Stereoselective Synthesis of Ribofuranoid exo-Glycals

by One-Pot Julia Olefination Using Ribofuranosyl Sulfones, Journal of Organic Chemistry 86 657-673
EG-21
[101]

Hirata Y., Tsunekawa Y., Takahashi M., Oh-hashi K., Kawaguchi K., Hayazaki M., Watanabe M.,

Koga K.-I., Hattori Y., Takemori H., Furuta K. (2021) ,Identification of novel neuroprotective N,Ndimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes,
Free Radical Biology and Medicine 174 225-235[102]

Hirata Y., Motoyama M., Kimura S., Takashima M., Ikawa T., Oh-hashi K., Kamatari Y.O.

(2021) ,Artepillin C, a major component of Brazilian green propolis, inhibits endoplasmic reticulum stressand protein aggregation, European Journal of Pharmacology 912 174572[103]

Oh-hashi K., Hasegawa T., Mizutani Y., Takahashi K., Hirata Y. (2021) ,Elucidation of brefeldin A-

induced ER and Golgi stress responses in Neuro2a cells, Molecular and Cellular Biochemistry 476 38693877[104]

Oh-hashi K., Hasegawa T., Naruse Y., Hirata Y. (2021) ,Molecular characterization of mouse CREB3

regulatory factor in Neuro2a cells, Molecular Biology Reports 48 5411-5420[105]

Ikawa T., Sato M., Oh-hashi K., Furuta K., Hirata Y. (2021) ,Oxindole–curcumin hybrid compoundHQKDQFHVWKHWUDQVFULSWLRQRIȖ-glutamylcysteine ligase, European Journal of Pharmacology 896 173898

[106]

Oh-hashi K., Kohno H., Hirata Y. (2021) ,Transcriptional regulation of the ER stress-inducible gene

Sec16B in Neuro2a cells, Molecular and Cellular Biochemistry 476 35-44
EG-22
[107]

Isogawa K., Asano M., Hayazaki M., Koga K., Watanabe M., Suzuki K., Kobayashi T., Kawaguchi

K., Ishizuka A., Kato S., Ito H., Hamamoto A., Koyama H., Furuta K., Takemori H.
(2021) ,Thioxothiazolidin derivative, 4-OST, inhibits melanogenesis by enhancing the specific recruitmentof tyrosinase-containing vesicles to lysosome, Journal of Cellular Biochemistry 122 667-678[108]

Yan H., Kanki H., Matsumura S., Kawano T., Nishiyama K., Sugiyama S., Takemori H., Mochizuki

H., Sasaki T. (2021) ,MiRNA-132/212 regulates tight junction stabilization in blood–brain barrier after
stroke, Cell Death Discovery 7 380[109]

Hayazaki M., Hatano O., Shimabayashi S., Akiyama T., Takemori H., Hamamoto A. (2021) ,Zebrafish

as a new model for rhododendrol-induced leukoderma, Pigment Cell and Melanoma Research 34 10291038[110]

Maeda M., Suzuki M., Takashima S., Sasaki T., Oh-Hashi K., Takemori H. (2021) ,The new live

imagers MitoMM1/2 for mitochondrial visualization, Biochemical and Biophysical ResearchCommunications 562 50-54[111]

Takahashi Y., Serada S., Ohkawara T., Fujimoto M., Hiramatsu K., Ueda Y., Kimura T., Takemori

H., Naka T. (2021) ,LSR promotes epithelial ovarian cancer cell survival under energy stress through the
LKB1-AMPK pathway, Biochemical and Biophysical Research Communications 537 93-99[112]

Hirata Y., Tsunekawa Y., Takahashi M., Oh-hashi K., Kawaguchi K., Hayazaki M., Watanabe M.,

Koga K.-I., Hattori Y., Takemori H., Furuta K. (2021) ,Identification of novel neuroprotective N,Ndimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes,
Free Radical Biology and Medicine 174 225-235
AG-04
[113]

Cai H.-L., Doi R., Shimada M., Hayakawa T., Nakagawa T. (2021) ,Metabolic regulation adapting tohigh methanol environment in the methylotrophic yeast Ogataea methanolica, Microbial Biotechnology 14
1512-1524[114]

Hibi M., Nakagawa T., Hayakawa T., Yanase E., Shimada M. (2021) ,Dietary supplementation with

myo-inositol reduces high-fructose diet-induced hepatic ChREBP binding and acetylation of histones H3and H4 on the Elovl6 gene in rats, Nutrition Research 88 28-33[115]

Tanaka T., Mizuno T., Nakagawa T., Hayakawa T., Shimada M. (2021) ,Effects of H3 and H4

Histones Acetylation and Bindings of CREB Binding Protein and p300 at the Promoter on Hepatic([SUHVVLRQ RI Ȗ-glutamyltransferase Gene in a Streptozotocin-Induced Moderate Hypoinsulinemic Rat
Model, Physiological Research 70 475-480

[116]

Hibi M., Sugiura S., Nakagawa T., Hayakawa T., Shimada M. (2021) ,Effects of dietary

supplementation with myo-inositol on hepatic expression of glycolytic and fructolytic enzyme genes in rats
fed a high-sucrose diet, Journal of Oleo Science 70 697-702[117]

Shimada M., Hibi M., Nakagawa T., Hayakawa T., Field C.J. (2021) ,High-fructose diet-induced

hepatic expression of the SCD1 gene is associated with increased acetylation of histones H3 and H4 andthe binding of chrebp at the SCD1 promoter in rats, Biomedical Research (Tokyo) 42 85-88
AG-06
[118]

Suzuki S. (2021) ,Carthamin Synthase Provides New Insight into Traditional 'Beni' Red Pigment

Production from Safflowers, Plant and Cell Physiology 62 1506-1508
AG-07
[119]

Tusi A., Shimazu T., Ochiai M., Suzuki K. (2021) ,Continuous measurement of greenhouse ventilation

rate in summer and autumn via heat and water vapor balance methods, Environmental Control in Biology
59 41-48[120]

Tusi A., Shimazu T., Ochiai M., Suzuki K. (2021) ,Comparison of three ventilation rate measurement

methods under different window apertures in winter and spring, Environmental Control in Biology 59[121]

Wu W., Ochiai M., Nakatsuka T., Yamada K., Fukui H. (2021) ,Evaluation of crown gall disease

UHVLVWDQFHLQK\EULGVRI5RVDµ3(.FRXJHO¶DQGWHWUDSORLGRI5PXOWLIORUDµPDWVXVKLPDQR¶+RUWLFXOWXUHJournal 90 122-129[122]

Nuraini L., Tatsuzawa F., Ochiai M., Suzuki K., Nakatsuka T. (2021) ,Two independent spontaneous

mutations related to anthocyanin-less flower coloration in matthiola incana cultivars, Horticulture Journal
90 85-96
AG-10
[123]

Akther J., Das A., Rahman M.A., Saha S.K., Hosen M.I., Ebihara A., Nakagawa T., Suzuki F., Nabi

A.H.M.N. (2021) ,Non-coding Single Nucleotide Variants of Renin and the (Pro)renin Receptor are
Associated with Polygenic Diseases in a Bangladeshi Population, Biochemical Genetics 59 1116-1145[124]

Hashimoto M., Kumabe A., Kim J.-D., Murata K., Sekizar S., Williams A., Lu W., Ishida J.,

Nakagawa T., Endo M., Minami Y., Fukamizu A. (2021) ,Loss of PRMT1 in the central nervous system(CNS) induces reactive astrocytes and microglia during postnatal brain development, Journal of
Neurochemistry 156 834-847[125]

Hashimoto M., Fukamizu A., Nakagawa T., Kizuka Y. (2021) ,Roles of protein arginine

methyltransferase 1 (PRMT1) in brain development and disease, Biochimica et Biophysica Acta - General
Subjects 1865 129776



AG-11[126]

Agrahari R.K., Enomoto T., Ito H., Nakano Y., Yanase E., Watanabe T., Sadhukhan A., Iuchi S.,

Kobayashi M., Panda S.K., Yamamoto Y.Y., Koyama H., Kobayashi Y. (2021) ,Expression GWAS of
PGIP1 Identifies STOP1-Dependent and STOP1-Independent Regulation of PGIP1 in Aluminum Stress
Signaling in Arabidopsis, Frontiers in Plant Science 12 774687[127]

Koyama H., Wu L., Agrahari R.K., Kobayashi Y. (2021) ,STOP1 regulatory system: Centered on

multiple stress tolerance and cellular nutrient management, Molecular plant 14 1615-1617[128]

Sadhukhan A., Kobayashi Y., Iuchi S., Koyama H. (2021) ,Synergistic and antagonistic pleiotropy of

STOP1 in stress tolerance, Trends in Plant Science 26 1014-1022[129]

Singh S., Koyama H., Bhati K.K., Alok A. (2021) ,The biotechnological importance of the plant-

specific NAC transcription factor family in crop improvement, Journal of Plant Research 134 475-495[130]

Awasthi J.P., Kusunoki K., Saha B., Kobayashi Y., Koyama H., Panda S.K. (2021) ,Comparative

RNA-Seq analysis of the root revealed transcriptional regulation system for aluminum tolerance incontrasting indica rice of North East India, Protoplasma 258 517-528[131]

Tokizawa M., Enomoto T., Ito H., Wu L., Kobayashi Y., Mora-Maciás J., Armenta-Medina D., Iuchi

S., Kobayashi M., Nomoto M., Tada Y., Fujita M., Shinozaki K., Yamamoto Y.Y., Kochian L.V., Koyama
H. (2021) , High affinity promoter binding of STOP1 is essential for the early aluminum-inducible
expression of novel Al resistance genes GDH1 and GDH2 in Arabidopsis, Journal of Experimental Botany
72 7
[132]

Agrahari R.K., Kobayashi Y., Tanaka T.S.T., Panda S.K., Koyama H. (2021) ,Smart fertilizer

management: the progress of imaging technologies and possible implementation of plant biomarkers inagriculture, Soil Science and Plant Nutrition 67 248-258[133]

Sadhukhan A., Agrahari R.K., Wu L., Watanabe T., Nakano Y., Panda S.K., Koyama H., Kobayashi

Y. (2021) ,Expression genome-wide association study identifies that phosphatidylinositol-derived
signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots ofArabidopsis thaliana, Plant Science 302 110711
AG-13
[134]

Tani A., Mitsui R., Nakagawa T. (2021) ,Discovery of lanthanide-dependent methylotrophy andscreening methods for lanthanide-dependent methylotrophs, Methods in Enzymology 650 1-18
[135]

Doi R., Wu Y., Kawai Y., Wang L., Zendo T., Nakamura K., Suzuki T., Shimada M., Hayakawa T.,

Nakagawa T. (2021) ,Transition and regulation mechanism of bacterial biota in Kishu saba-narezushi(mackerel narezushi) during its fermentation step, Journal of Bioscience and Bioengineering 132 606-612

[136]

Ma P., Takashima S., Fujita C., Yamada S., Oshima Y., Cai H.-L., Yurimoto H., Sakai Y., Hayakawa

T., Shimada M., Ning X., Wei B., Nakagawa T. (2021) ,Fatty acid composition of the methylotrophic yeast
Komagataella phaffii grown under low- and high-methanol conditions, Yeast 38 541-548[137]

Cai H.-L., Doi R., Shimada M., Hayakawa T., Nakagawa T. (2021) ,Metabolic regulation adapting tohigh methanol environment in the methylotrophic yeast Ogataea methanolica, Microbial Biotechnology 14
1512-1524
AG-15
[138]

Sheng X., Tanaka M., Katagihara R., Hashimoto M., Nagaoka S., Matsui T. (2021) ,Novel Approachfor Simultaneous Analysis of Peptide Metabolites from Orally Administered Glycinin in Rat Bloodstream
by Coumarin-Tagged MALDI-MS, Journal of Agricultural and Food Chemistry 69 14840-14848[139]

Mijiti M., Mori R., Huang B., Tsukamoto K., Kiriyama K., Sutoh K., Nagaoka S. (2021) ,Anti-obesityand hypocholesterolemic actions of protamine-derived peptide rpr (Arg-pro-arg) and protamine in high-fat
diet-induced c57bl/6j mice, Nutrients 13 2501
[140]

Nagaoka S., Takeuchi A., Banno A. (2021) ,Plant-derived peptides improving lipid and glucose

metabolism, Peptides 142 170577[141]

Sheng X., Nagaoka S., Hashimoto M., Amiya Y., Beppu M., Tsukamoto K., Yanase E., Tanaka M.,

0DWVXL 7   ,GHQWLILFDWLRQ RI SHSWLGHV LQ EORRG IROORZLQJ RUDO DGPLQLVWUDWLRQ RI ȕ-conglycinin to
Wistar rats, Food Chemistry 341 128197
[142]

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[143]

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ཤ, ࡖ໼৿ଢ (2021) ৱ඾‫ؽ‬೵੓ϘϕοχͳϘϕοχ༎ૻ୴ର, ੊ֆॵ͹ࢹ࣯େःր

વζϘϕοχ FPʤPhe-Proʥ͹ࡠ༽‫ߑؽ‬. Կָͳਫ਼෼ 59, 367-368ʤ૱ઈʥ
AG-17
[144]

Onishi-Sakamoto S., Makishi K., Takami K., Asahina R., Maeda S., Nagata M., Moore P.F., Ide K.,

Nishifuji K. (2021) ,Narrow-band ultraviolet B therapy attenuates cutaneous T-cell responses in hapteninduced, experimental contact dermatitis in beagles, Veterinary Dermatology 32 605-e161[145]

Kimura S., Nakata K., Nakano Y., Nozue Y., Konno N., Sugawara T., Maeda S., Kamishina H.

(2021) ,Case Report: Spinal Stabilization Surgery Using a Novel Custom-Made Titanium Fixation System
for the Spinal Instability Caused by Vertebral Malformation in a Dog, Frontiers in Veterinary Science 8755572[146]

Kamishina H., Nakano Y., Nozue Y., Nakata K., Kimura S., Drury A.G., Maeda S.

(2021) ,Microendoscopic mini-hemilaminectomy and discectomy in acute thoracolumbar disc extrusion
dogs: A pilot study, Veterinary Sciences 8 241

[147]

Kobatake Y., Nakata K., Sakai H., Sasaki J., Yamato O., Takashima S., Nishii N., Maeda S., Islam

M.S., Kamishina H. (2021) ,The long-term clinical course of canine degenerative myelopathy andtherapeutic potential of curcumin, Veterinary Sciences 8 192[148]

Tanaka N., Kimura S., Kamatari Y.O., Nakata K., Kobatake Y., Inden M., Yamato O., Urushitani M.,

Maeda S., Kamishina H. (2021) ,In vitro evidence of propagation of superoxide dismutase-1 protein
aggregation in canine degenerative myelopathy, Veterinary Journal 274 105710[149]

Naito E., Nakata K., Nakano Y., Nozue Y., Kimura S., Sakai H., Yamato O., Islam M.S., Maeda S.,

Kamishina H. (2021) ,Changes of dorsal root ganglion volume in dogs with clinical signs of degenerative
myelopathy detected by water-excitation magnetic resonance imaging, Animals 11 1702
[150]

Kuwahara Y., Yoshizaki K., Nishida H., Kamishina H., Maeda S., Takano K., Fujita N., Nishimura

R., Jo J.-I., Tabata Y., Akiyoshi H. (2021) ,Extracellular Vesicles Derived From Canine Mesenchymal
Stromal Cells in Serum Free Culture Medium Have Anti-inflammatory Effect on Microglial Cells,
Frontiers in Veterinary Science 8 633426[151]

Nakata K., Namiki M., Kobatake Y., Nishida H., Sakai H., Yamato O., Urushitani M., Maeda S.,

Kamishina H. (2021) ,Up-regulated spinal microRNAs induce aggregation of superoxide dismutase 1
protein in canine degenerative myelopathy, Research in Veterinary Science 135 479-485[152]

Hashimoto K., Kobatake Y., Asahina R., Yamato O., Islam M.S., Sakai H., Nishida H., Maeda S.,

Kamishina H. (2021) ,Up-regulated inflammatory signatures of the spinal cord in canine degenerative
myelopathy, Research in Veterinary Science 135 442-449[153]

Sakamoto K., Nozue Y., Murakami M., Nakata K., Nakano Y., Soga S., Maeda S., Kamishina H.

(2021) ,Minimally invasive spinal surgery in a young cat with vertebral hypertrophy, Journal of Feline
Medicine and Surgery Open Reports 7[154]

Tanaka N., Kanei T., Iwata M., Kawabe M., Kamishina H., Murakami M., Sakai H., Maeda S.

(2021) ,Detection of granzyme b in cd3-positive cells infiltrated in lesional skin of a dog with erythemamultiforme associated with zonisamide, Journal of Veterinary Medical Science 83 1559-1562
AG-22
[155]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Kitamura Y., Shimizu K., Okada A., Inoshima

Y. (2021) ,Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected
cattle, Scientific Reports 11 2951
[156]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Shimizu K., Okada A., Inoshima Y.

(2021) ,Putative internal control genes in bovine milk small extracellular vesicles suitable for normalizationin quantitative real time-polymerase chain reaction, Membranes 11 933

[157]

Rahman M.M., Takashima S., Kamatari Y.O., Shimizu K., Okada A., Inoshima Y.

(2021) ,Comprehensive proteomic analysis revealed a large number of newly identified proteins in thesmall extracellular vesicles of milk from late-stage lactating cows, Animals 11 2506
[158]

Kamiya S., Shimizu K., Okada A., Inoshima Y. (2021) ,Induction of serum amyloid a3 in mouse

mammary epithelial cells stimulated with lipopolysaccharide and lipoteichoic acid, Animals 11 1548
[159]

Okada A., Hotta A., Kimura M., Park E.-S., Morikawa S., Inoshima Y. (2021) ,A retrospective surveyof the seroprevalence of severe fever with thrombocytopenia syndrome virus in wild animals in Japan,
Veterinary Medicine and Science 7 600-605
AG-23
[160]

Watanabe M., Sumita Y., Azechi I., Ito K., Noda K. (2021) ,The value chain of locally grown japonica

rice in mwea, kenya, Agriculture (Switzerland) 11 974[161]

Watanabe M., Sumita Y., Azechi I., Ito K., Noda K. (2021) ,Production costs and benefits of japonica

rice in Mwea, Kenya, Agriculture (Switzerland) 11 629
AG-24
[162]

Shimaoka H., Shiina T., Suzuki H., Horii Y., Horii K., Shimizu Y. (2021) ,Successful induction ofdeep hypothermia by isoflurane anesthesia and cooling in a non-hibernator, the rat, Journal of Physiological
Sciences 71 10[163]

Horii K., Ehara Y., Shiina T., Naitou K., Nakamori H., Horii Y., Shimaoka H., Saito S., Shimizu Y.

(2021) ,Sexually dimorphic response of colorectal motility to noxious stimuli in the colorectum in rats,
Journal of Physiology 599 1421-1437
AG-25
[164]

Abe J., Iritani R., Tsuchida K., Kamimura Y., West S.A. (2021) ,A solution to a sex ratio puzzle in

Melittobia wasps, Proceedings of the National Academy of Sciences of the United States of America 118
e2024656118
AG-27
[165]

Takayama S., Kawanishi M., Yamauchi K., Tokumitsu D., Kojima H., Masutani T., Iddamalgoda A.,

Mitsunaga T., Tanaka H. (2021) ,Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8
production in human keratinocytes, Journal of Natural Medicines 75 623-632[166]

Kakumu Y., Nguyen T.M.T., Yamauchi K., Mitsunaga T. (2021) ,New benzoic acid and caffeoyl

derivatives with anti-inflammatory activities isolated from leaves of Ilex kaushue, Natural ProductResearch 12 1-9AG-29[167]

Horii K., Ehara Y., Shiina T., Naitou K., Nakamori H., Horii Y., Shimaoka H., Saito S., Shimizu Y.

(2021) ,Sexually dimorphic response of colorectal motility to noxious stimuli in the colorectum in rats,
Journal of Physiology 599 1421-1437[168]

Sarkar S., Homma T., Onouchi S., Shimizu Y., Shiina T., Nabeka H., Matsuda S., Saito S.

(2021) ,Expression of the g protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestivesystem, Journal of Veterinary Medical Science 83 1-8
AG-32
[169]

Yoshizaki K., Hirata A., Matsushita H., Nishii N., Kawabe M., Mori T., Sakai H. (2021) ,PCR-based

genotyping assays to detect germline APC variant associated with hereditary gastrointestinal polyposis in
Jack Russell terriers, BMC Veterinary Research 17 32[170]

Kobatake Y., Nakata K., Sakai H., Sasaki J., Yamato O., Takashima S., Nishii N., Maeda S., Islam

M.S., Kamishina H. (2021) ,The long-term clinical course of canine degenerative myelopathy andtherapeutic potential of curcumin, Veterinary Sciences 8 192[171]

Yoshizaki K., Hirata A., Nishii N., Kawabe M., Goto M., Mori T., Sakai H. (2021) ,Familial

adenomatous polyposis in dogs: Hereditary gastrointestinal polyposis in Jack Russell Terriers with
germline APC mutations, Carcinogenesis 42 70-79[172]

Heishima K., Sugito N., Soga T., Nishikawa M., Ito Y., Honda R., Kuranaga Y., Sakai H., Ito R.,

Nakagawa T., Ueda H., Akao Y. (2021) ,Petasin potently inhibits mitochondrial complex I–based
metabolism that supports tumor growth and metastasis, Journal of Clinical Investigation 131 e139933[173]

Goto S., Iwasaki R., Sakai H., Mori T. (2021) ,A retrospective analysis on the outcome of 18 dogs

with malignant ovarian tumours, Veterinary and Comparative Oncology 19 442-450[174]

Naito E., Nakata K., Nakano Y., Nozue Y., Kimura S., Sakai H., Yamato O., Islam M.S., Maeda S.,

Kamishina H. (2021) ,Changes of dorsal root ganglion volume in dogs with clinical signs of degenerative
myelopathy detected by water-excitation magnetic resonance imaging, Animals 11 1702
[175]

Morinaga Y., Igase M., Yanase T., Sakai Y., Sakai H., Fujiwara-Igarashi A., Tsujimoto H., Okuda M.,

Mizuno T. (2021) ,Expression of DEP Domain-Containing 1B in Canine Lymphoma and Other Types ofCanine Tumours, Journal of Comparative Pathology 185 55-65[176]

Nakata K., Namiki M., Kobatake Y., Nishida H., Sakai H., Yamato O., Urushitani M., Maeda S.,

Kamishina H. (2021) ,Up-regulated spinal microRNAs induce aggregation of superoxide dismutase 1
protein in canine degenerative myelopathy, Research in Veterinary Science 135 479-485[177]

Hashimoto K., Kobatake Y., Asahina R., Yamato O., Islam M.S., Sakai H., Nishida H., Maeda S.,

Kamishina H. (2021) ,Up-regulated inflammatory signatures of the spinal cord in canine degenerative
myelopathy, Research in Veterinary Science 135 442-449

[178]

Tanaka N., Kanei T., Iwata M., Kawabe M., Kamishina H., Murakami M., Sakai H., Maeda S.

(2021) ,Detection of granzyme b in cd3-positive cells infiltrated in lesional skin of a dog with erythemamultiforme associated with zonisamide, Journal of Veterinary Medical Science 83 1559-1562
AG-33
[179]

Nakagawa K., Kumano H., Kitamura Y., Kuwata K., Tanaka E., Fukushi H. (2021) ,Complete genome

sequence of bovine coronavirus in blood diarrhea from adult cattle that died from winter dysentery in Japan,
Microbiology Resource Announcements 10 e00807[180]

Nagai M., Okabayashi T., Akagami M., Matsuu A., Fujimoto Y., Hashem M.A., Mekata H., Nakao

R., Matsuno K., Katayama Y., Oba M., Omatsu T., Asai T., Nakagawa K., Ito H., Madarame H., Kawai
K., Ito T., Nonaka N., Tsukiyama-Kohara K., Inoshima Y., Mizutani T., Misawa N. (2021) ,Metagenomic
identification, sequencing, and genome analysis of porcine hepe-astroviruses (bastroviruses) in porcine
feces in Japan, Infection, Genetics and Evolution 88 104664[181]

Nakagawa K., Makino S. (2021) ,Mechanisms of coronavirus nsp1-mediated control of host and viralgene expression, Cells 10 1-18
AG-36
[182]

Nakagawa K., Kumano H., Kitamura Y., Kuwata K., Tanaka E., Fukushi H. (2021) ,Complete genome

sequence of bovine coronavirus in blood diarrhea from adult cattle that died from winter dysentery in Japan,
Microbiology Resource Announcements 10 e00807
AG-37
[183]

Takashima S., Nagamori Y., Ohata K., Oikawa T., Sugaya T., Kobatake Y., Nishii N. (2021) ,Clinicalevaluation of urinary liver-type fatty acid-binding protein for the diagnosis of renal diseases in dogs,
Journal of Veterinary Medical Science 83 1465-1471
AG-42
[184]

Brice A.M., Watts E., Hirst B., Jans D.A., Ito N., Moseley G.W. (2021) ,Implication of the nuclear

trafficking of rabies virus P3 protein in viral pathogenicity, Traffic 22 482-489[185]

Yumoto K., Arisaka T., Okada K., Aoki K., Ose T., Masatani T., Sugiyama M., Ito N., Fukuhara H.,

Maenaka K. (2021) ,Characterization of single-chain fv fragments of neutralizing antibodies to rabies virus
glycoprotein, Viruses 13 2311
[186]

Zhan J., Harrison A.R., Portelli S., Nguyen T.B., Kojima I., Zheng S., Yan F., Masatani T., Rawlinson

S.M., Sethi A., Ito N., Ascher D.B., Moseley G.W., Gooley P.R. (2021) ,Definition of the immune evasionreplication interface of rabies virus P protein, PLoS Pathogens 17 e1009729[187]

Kojima I., Izumi F., Ozawa M., Fujimoto Y., Okajima M., Ito N., Sugiyama M., Masatani T.

(2021) ,Analyses of cell death mechanisms related to amino acid substitution at position 95 in the rabies
virus matrix protein, Journal of General Virology 102 1594



AG-44[188]

Shamaev N.D., Shuralev E.A., Nikitin O.V., Mukminov M.N., Davidyuk Y.N., Belyaev A.N., Isaeva

G.S., Ziatdinov V.B., Khammadov N.I., Safina R.F., Salmanova G.R., Akhmedova G.M., Khaertynov K.S.,
Saito T., Kitoh K., Takashima Y. (2021) ,Prevalence of Toxoplasma gondii infection among small
mammals in Tatarstan, Russian Federation, Scientific Reports 11 22184[189]

Saito T., Kitamura Y., Tanaka E., Ishigami I., Taniguchi Y., Moribe J., Kitoh K., Takashima Y.

(2021) ,Spatial distribution of anti-Toxoplasma gondii antibody-positive wild boars in Gifu Prefecture,
Japan, Scientific Reports 11 17207[190]

Saito T., Masatani T., Kitoh K., Takashima Y. (2021) ,Releasing latent Toxoplasma gondii cysts fromhost cells to the extracellular environment induces excystation, International Journal for Parasitology 51
999-1006[191]

Saito T., Hayashi K., Hayashi K., Akita Y., Une Y., Kuroki T., Shibahara T., Takashima Y.

(2021) ,Morphological observation and first molecular characterization of Grassenema procaviae Petter,
1959 (Cosmocercoidea: Atractidae) in the stomach of Cape hyrax (Procavia capensis) raised in a zoo inJapan, Parasitology International 84 102385[192]

Hayashi K., Kitayama C., Saito T., Ohari Y., Hayashi K., Kondo S., Takashima Y., Kuroki T.,

Shibahara T., Itagaki T. (2021) ,Detection and molecular characteristics of Pyelosomum cochlear (Digenea:
Pronocephalidae) in the urinary bladder of the green sea turtle (Chelonia mydas) in the Northwest Pacific
Ocean, Infection, Genetics and Evolution 93 104962[193]

Kitayama C., Hayashi K., Hayashi K., Igarashi H., Kondo S., Ogawa R., Hashimoto T., Okubo S.,

Takashima Y., Itagaki T., Kuroki T., Shibahara T. (2021) ,Detection and molecular characteristics ofRhytidodoides sp. (Digenea: Rhytidodidae) from the gall bladder of green sea turtles (Chelonia mydas) in
the Ogasawara Islands, Japan, Parasitology International 83 102377[194]

Ohari Y., Hayashi K., Takashima Y., Itagaki T. (2021) ,Do aspermic (parthenogenetic) Fasciola forms

have the ability to reproduce their progeny via parthenogenesis?, Journal of helminthology 95 e36[195]

Waki T., Ohari Y., Hayashi K., Moribe J., Matsuo K., Takashima Y. (2021) ,The first detection of

Dicrocoelium chinensis sporocysts from the land snail Aegista vulgivaga in Gifu Prefecture, Japan, The
Journal of veterinary medical science 83 957-961[196]

Shoshi Y., Kazato K., Maeda T., Takashima Y., Watari Y., Matsumoto Y., Miyashita T., Sanjoba C.

(2021) ,Prevalence of serum antibodies to toxoplasma gondii in free-ranging cats on tokunoshima island,japan, Journal of Veterinary Medical Science 83 333-337
AG-51
[197]

Toda Y., Ko M.-C., Liang Q., Miller E.T., Rico-Guevara A., Nakagita T., Sakakibara A., Uemura K.,

Sackton T., Hayakawa T., Sin S.Y.W., Ishimaru Y., Misaka T., Oteiza P., Crall J., Edwards S.V., ButtemerW., Matsumura S., Baldwin M.W. (2021) ,Early origin of sweet perception in the songbird radiation,
Science 373 226-231
AG-52
[198]

Agrahari R.K., Enomoto T., Ito H., Nakano Y., Yanase E., Watanabe T., Sadhukhan A., Iuchi S.,

Kobayashi M., Panda S.K., Yamamoto Y.Y., Koyama H., Kobayashi Y. (2021) ,Expression GWAS of
PGIP1 Identifies STOP1-Dependent and STOP1-Independent Regulation of PGIP1 in Aluminum Stress
Signaling in Arabidopsis, Frontiers in Plant Science 12 774687[199]

Kudo H., Matsuo M., Satoh S., Hata T., Hachisu R., Nakamura M., Yamamoto Y.Y., Kimura H.,

Matsui M., Obokata J. (2021) ,Cryptic promoter activation occurs by at least two different mechanisms in
the Arabidopsis genome, Plant Journal 108 29-39[200]

Sharma P.K., Goud V.V., Yamamoto Y., Sahoo L. (2021) ,Efficient Agrobacterium tumefaciens-

mediated stable genetic transformation of green microalgae, Chlorella sorokiniana, 3 Biotech 11 196[201]

Tokizawa M., Enomoto T., Ito H., Wu L., Kobayashi Y., Mora-Maciás J., Armenta-Medina D., Iuchi

S., Kobayashi M., Nomoto M., Tada Y., Fujita M., Shinozaki K., Yamamoto Y.Y., Kochian L.V., Koyama
H. (2021) ,High affinity promoter binding of STOP1 is essential for early expression of novel aluminuminduced resistance genes GDH1 and GDH2 in Arabidopsis, Journal of Experimental Botany 72 2769-2789[202]

Hayami N., Yamamoto Y.Y. (2021) ,Primary metabolism and transcriptional regulation in higher

plants, Reviews in Agricultural Science 9 117-127[203]

Nomoto M., Skelly M.J., Itaya T., Mori T., Suzuki T., Matsushita T., Tokizawa M., Kuwata K., Mori

H., Yamamoto Y.Y., Higashiyama T., Tsukagoshi H., Spoel S.H., Tada Y. (2021) ,Suppression of MYC
transcription activators by the immune cofactor NPR1 fine-tunes plant immune responses, Cell Reports 37
110125
AG-55[204]

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gallate in aqueous solution under heating conditions, Tetrahedron Letters 73 153140[205]

Hibi M., Nakagawa T., Hayakawa T., Yanase E., Shimada M. (2021) ,Dietary supplementation with

myo-inositol reduces high-fructose diet-induced hepatic ChREBP binding and acetylation of histones H3and H4 on the Elovl6 gene in rats, Nutrition Research 88 28-33[206]

Sheng X., Nagaoka S., Hashimoto M., Amiya Y., Beppu M., Tsukamoto K., Yanase E., Tanaka M.,

0DWVXL 7   ,GHQWLILFDWLRQ RI SHSWLGHV LQ EORRG IROORZLQJ RUDO DGPLQLVWUDWLRQ RI ȕ-conglycinin to
Wistar rats, Food Chemistry 341 128197[207]

Altaib H., Nakamura K., Abe M., Badr Y., Yanase E., Nomura I., Suzuki T. (2021) ,Differences in theconcentration of the fecal neurotransmitters GABA and glutamate are associated with microbial
composition among healthy human subjects, Microorganisms 9 1-15

[208]

Agrahari R.K., Enomoto T., Ito H., Nakano Y., Yanase E., Watanabe T., Sadhukhan A., Iuchi S.,

Kobayashi M., Panda S.K., Yamamoto Y.Y., Koyama H., Kobayashi Y. (2021) ,Expression GWAS of
PGIP1 Identifies STOP1-Dependent and STOP1-Independent Regulation of PGIP1 in Aluminum Stress
Signaling in Arabidopsis, Frontiers in Plant Science 12 774687
AG-57
[209]

Kaneko A., Takasu M., Miyabe-Nishiwaki T., Nakamura K., Okamoto M. (2021) ,Physiologicalvariation in Japanese macaques (Macaca fuscata) housed in different outdoor cages evaluated using themetabolic profile test, Primates 62 609-615[210]

Tozaki T., Ohnuma A., Takasu M., Nakamura K., Kikuchi M., Ishige T., Kakoi H., Hirora K.-I.,

Tamura N., Kusano K., Nagata S.-I. (2021) ,Detection of non-targeted transgenes by whole-genome
resequencing for gene-doping control, Gene Therapy 28 199-205[211]

Fujishiro T., Aoyama T., Hano K., Takasu M., Takeuchi M., Hasegawa Y. (2021) ,Microinjection

System to Enable Real-Time 3D Image Presentation through Focal Position Adjustment, IEEE Robotics
and Automation Letters 6 4025-4031[212]

Imaeda N., Ando A., Matsubara T., Takasu M., Nishii N., Miyamoto A., Ohshima S., Kametani Y.,

Suzuki S., Shiina T., Ono T., Kulski J.K., Kitagawa H. (2021) ,Stillbirth rates and their association withswine leucocyte antigen class II haplotypes in Microminipigs, Animal Bioscience 34 1749-1756
AG-58
[213]

Tadano R, Mori M, Sakaoka K, Kurita M. (2021) , Characterization of microsatellite markers forpaternity analysis in captive loggerhead turtles (Caretta caretta), Japanese Journal of Zoo and Wildlife
Medicine 26 81-85
AG-62
[214]

Ueda H., Fukuta R., Ohno T., Moriyama A., Himaki T., Iwahashi H., Moritomi H. (2021) ,Assessmentof biological effects and harm to Japanese medaka due to carbonized carbon fibers generated by a pyrolysis
carbon fiber recycling process, Journal of Material Cycles and Waste Management 23 1071-1080[215]

Takahashi J., Nagasawa S., Doi M., Takahashi M., Narita Y., Yamamoto J., Ikemoto M.J., Iwahashi

H. (2021) ,In vivo study of the efficacy and safety of 5-aminolevulinic radiodynamic therapy forglioblastoma fractionated radiotherapy, International Journal of Molecular Sciences 22 9762
[216]

Hasegawa T., Hapsari D., Iwahashi H. (2021) ,RNase H-dependent amplification improves theaccuracy of rolling circle amplification combined with loop-mediated isothermal amplification (RCALAMP), PeerJ 9 e11851[217]

Ito F., Niwa R., Syaputri Y., Ikagawa Y., Mizuno T., Horie M., Iwahashi H. (2021) ,Draft genome

sequence of lactiplantibacillus pentosus AWA1501, isolated from Awa-bancha, Microbiology Resource
Announcements 10 e00518

[218]

Yu T., Kuwahara S., Ohno T., Iwahashi H. (2021) ,Recycling salmon meat by decontamination under

mild conditions using high-pressure carbon dioxide, Waste Management 124 102-109[219]

Ueda H., Moriyama A., Iwahashi H., Moritomi H. (2021) ,Organizational issues for disseminating

recycling technologies of carbon fiber-reinforced plastics in the Japanese industrial landscape, Journal of
Material Cycles and Waste Management 23 505-515[220]

Pumkaeo P., Takahashi J., Iwahashi H. (2021) ,Detection and monitoring of insect traces inbioaerosols, PeerJ 9 e10862[221]

Hasegawa T., Hapsari D., Iwahashi H. (2021) ,Challenges for accurate quantification of rna, Reviewsin Agricultural Science 9 1-19
[222]

Pumkaeo P. Lu, W. Endou Y., Mizuno, T., Takahashi, J., and Iwahashi H (2021) ,Biological Trace

Information Extracted from Bioaerosols Using NGS Analysis, Bioscience Journal 37 e37090[223]

Yolani, S., Parwi, and Iwahashi H (2021) ,Plantaricin A of Lactobacillus plantarum IYP1718 Plays aRole in Controlling Undesirable Organisms in Soil, Research Journal of Biotechnology 16 141-147[224]

Yolani, S., Niwa, R., & Iwahashi, H (2021) ,Effect of pH and Salinity on Lactic Acid Production andMultiplication of Plantaricin Plasmid Genes of Lactobacillus plantarum COY 2906 Isolated from Virgin
Coconut Oil, Research Journal of Biotechnology 16 1-8
AG-65
[225]

Odoi J.O., Yamamoto M., Sugiyama M., Asai T. (2021) ,Antimicrobial resistance inEnterobacteriaceae isolated from arthropods in Gifu City, Japan, Microbiology and Immunology 65 136141[226]

Aratani T., Koide N., Hayami K., Sugiyama M., Minamoto T., Asai T. (2021) ,Continuous prevalenceof VEB-3 extended-VSHFWUXPȕ-lactamase-producing Aeromonas hydrophila in a local river in gifu city,
Japan, Microbiology and Immunology 65 99-100[227]

Kitamura Y., Odoi J.O., Nagai M., Asai T. (2021) ,Prevalence of honeybee viruses in apis mellifera

in gifu prefecture of Japan, Journal of Veterinary Medical Science 83 1948-1951[228]

Odoi J.O., Sugiyama M., Kitamura Y., Sudo A., Omatsu T., Asai T. (2021) ,Prevalence ofantimicrobial resistance in bacteria isolated from great cormorants (Phalacrocorax carbo hanedae) in japan,
Journal of Veterinary Medical Science 83 1191-1195[229]

Yossapol M., Yamamoto M., Sugiyama M., Odoi J.O., Omatsu T., Mizutani T., Ohya K., Asai T.

(2021) ,Association between the blactx-m-14-harboring escherichia coli isolated from weasels anddomestic animals reared on a university campus, Antibiotics 10 432[230]

Ikushima S., Torii H., Asano M., Suzuki M., Asai T. (2021) ,Clonal spread of quinolone-resistantescherichia coli among sika deer (Cervus nippon) inhabiting an urban city park in Japan, Journal of Wildlife
Diseases 57 172-177



AG-67[231]

Uehara, S., Matsubara, Y., Taniguchi, T., Ozaki, T. and Tazawa, Y. (2021) ,Growth promotion andchanges in functional components of mycorrhizal Platycodon grandifloras, J. JSATM 28 37-43[232]

Hasib, A., Kobayashi, M. and Matsubara, Y. (2021) ,Changes in secondary metabolites and free aminoacid content in tomato with Lamiaceae herbs companion planting, Am. J. Plant Sci 11 1878-1889[233]

ন‫ݬ‬ཇҲʁ‫ز‬෠୉ָ COC ࣆ‫ۂ‬. ஏҮࢦ޴ָ‫ڂݜ‬ϕϫζΥέφʰ༂༽৪෼ΫΫϥΤ͹߶‫ؽ‬೵Կ‫ࢊ;ٶ‬ஏ‫ܙ‬੔ਬ਒ʱ. ྫ࿪ 2 ೧ౕஏҮࢦ޴ָϕϫζΥέφๅࠄ. ஏҮࢦ޴ָ‫ڂݜ‬. Vol.5:96-99,
2021.
AG-68
[234]

A.H.M. Nurun Nabi and Akio Ebihara (2021) ,Diabetes and Renin-Angiotensin-Aldosterone System:

Pathophysiology

andGenetics,

Pathophysiology

andGenetics.

IntechOpen

DOI:

10.5772/intechopen.97518[235]

Tahara, N., Tachibana, I., Takeo, K., Yamashita, S., Shimada, A., Hashimoto, M., Ohno, S.,

Yokogawa, T., Nakagawa, T., Suzuki, F., and Ebihara, A. (2021) ,Boosting Auto-induction of RecombinantProteins in Escherichia coli with Glucose and Lactose Additives, Protein and Peptide Letters 28 1180-1190
AG-72
[236]

Elsharkawy M.M., Khedr A.A., Mehiar F., El-Kady E.M., Baazeem A., Shimizu M.

(2021) ,Suppression of Pseudomonas syringae pv. tomato infection by rhizosphere fungi, Pest Management
Science 77 4350-4356[237]

Marian M., Fujikawa T., Shimizu M. (2021) ,Genome analysis provides insights into the biocontrol

ability of Mitsuaria sp. strain TWR114, Archives of Microbiology 203 3373-3388[238]

Ahsan N., Marian M., Suga H., Shimizu M. (2021) ,Lysinibacillus xylanilyticus strain gic41 as apotential plant biostimulant, Microbes and Environments 36 ME21047[239]

Ahsan N., Shimizu M. (2021) ,Lysinibacillus species: Their potential as effective bioremediation,biostimulant, and biocontrol agents, Reviews in Agricultural Science 9 103-116[240]

Sultana S., Bao W.X., Shimizu M., Kageyama K., Suga H. (2021) ,Frequency of three mutations in

the fumonisin biosynthetic gene cluster of Fusarium fujikuroi that are predicted to block fumonisin
production, World Mycotoxin Journal 14 49-59
AG-75
[241]

Kajino R., Ueno Y. (2021) ,(S)-ƍ-C-Aminopropyl-ƍ-O-methyl nucleosides enhance antisense activity

in cultured cells and binding affinity to complementary single-stranded RNA, Bioorganic and Medicinal
Chemistry 30 115925

[242]

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enhanced nuclease resistance of RNAs and improved thermal stability of RNA duplexes, Results in
Chemistry 3 100231[243]ׁ໼ ྐฑ,৏໼ٝਖ (2021) ֫࢐ҫ༂Νࢨ޴ͪ͢ΩοΨϱ੓ଈ࠱Ν༙ͤΖ৿‫و‬ਕ޽֫࢐͹߻੔, ༙‫߻ؽ‬੔Կָ‫ڢ‬ճࢿ. 79: 1102-1112,.
AG-77
[244]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Kitamura Y., Shimizu K., Okada A., Inoshima

Y. (2021) ,Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected
cattle, Scientific Reports 11 2951
[245]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Shimizu K., Okada A., Inoshima Y.

(2021) ,Putative internal control genes in bovine milk small extracellular vesicles suitable for normalizationin quantitative real time-polymerase chain reaction, Membranes 11 933[246]

Rahman M.M., Takashima S., Kamatari Y.O., Shimizu K., Okada A., Inoshima Y.

(2021) ,Comprehensive proteomic analysis revealed a large number of newly identified proteins in thesmall extracellular vesicles of milk from late-stage lactating cows, Animals 11 2506
[247]

Sahashi Y., Oshima M., Yamagishi J., Muramatsu C., Shimizu K., Inoshima Y. (2021) ,Bovine

leukemia virus genotype surveillance in cattle at a slaughterhouse in Aichi prefecture, Japan, in 2019 using
polymerase chain reaction combined with restriction fragment length polymorphism, Journal of Veterinary
Medical Science 83 1730-1734[248]

Kato M., Kawashima D., Ito Y., Yamamoto O., Nakajima H., Oizumi T., Shimizu K., Inoshima Y.

(2021) ,Successful measures to prevent the spread of bovine papular stomatitis in a dairy farm, Journal of
Veterinary Medical Science 83 304-308
AG-84
[249]

Zeng Y., Shinada K., Hano K., Sui L., Yang T., Li X., Himaki T. (2021) ,Effects of tris (2-carboxyethyl) phosphine hydrochloride treatment on porcine oocyte in vitro maturation and subsequent invitro fertilized embryo developmental capacity, Theriogenology 162 32-41
AG-85
[250]

Kobayashi C., Inagaki M., Nohara M., Fukuoka M., Xijier, Yabe T., Kanamarua Y. (2021) ,The effects

of denatured major bovine whey proteins on the digestive tract, assessed by Caco-2 cell differentiation andon viability of suckling mice, Journal of Dairy Research 88 221-225
DM-02
[251]

Nomura T.K., Heishima K., Sugito N., Sugawara R., Ueda H., Yukihiro A., Honda R. (2021) ,Specificinhibition of oncogenic RAS using cell-permeable RAS-binding domains, Cell Chemical Biology 28 15811589.e6

[252]Heishima K., Sugito N., Soga T., Nishikawa M., Ito Y., Honda R., Kuranaga Y., Sakai H., Ito R.,

Nakagawa T., Ueda H., Akao Y. (2021) ,Petasin potently inhibits mitochondrial complex I–based
metabolism that supports tumor growth and metastasis, Journal of Clinical Investigation 131 e139933[253]

Fukada M., Matsuhashi N., Takahashi T., Sugito N., Heishima K., Yoshida K., Akao Y.

(2021) ,Postoperative changes in plasma miR21-5p as a novel biomarker for colorectal cancer recurrence:
A prospective study, Cancer Science 112 4270-4280[254]

Weiss S.A., Zito C., Tran T., Heishima K., Neumeister V., McGuire J., Adeniran A., Kluger H.,

Jilaveanu L.B. (2021) ,Melanoma brain metastases have lower T-cell content and microvessel density
compared to matched extracranial metastases, Journal of Neuro-Oncology 152 15-25
DM-04
[255]

Nomura T.K., Heishima K., Sugito N., Sugawara R., Ueda H., Yukihiro A., Honda R. (2021) ,Specificinhibition of oncogenic RAS using cell-permeable RAS-binding domains, Cell Chemical Biology 28 15811589.e6[256]

Heishima K., Sugito N., Soga T., Nishikawa M., Ito Y., Honda R., Kuranaga Y., Sakai H., Ito R.,

Nakagawa T., Ueda H., Akao Y. (2021) ,Petasin potently inhibits mitochondrial complex I–based
metabolism that supports tumor growth and metastasis, Journal of Clinical Investigation 131 e139933
DM-05
[257]

Umetsu R., Tanaka M., Nakayama Y., Kato Y., Ueda N., Nishibata Y., Hasegawa S., Matsumoto K.,

Takeyama N., Iguchi K., Tanaka H., Hinoi E., Inagaki N., Inden M., Muto Y., Nakamura M.
(2021) ,Neuropsychiatric Adverse Events of Montelukast: An Analysis of Real-World Datasets and
GUXJíJHQH,QWHUDFWLRQ1HWZRUN)URQWLers in Pharmacology 12 764279[258]

Fukasawa K., Kadota T., Horie T., Tokumura K., Terada R., Kitaguchi Y., Park G., Ochiai S.,

Iwahashi S., Okayama Y., Hiraiwa M., Yamada T., Iezaki T., Kaneda K., Yamamoto M., Kitao T.,
Shirahase H., Hazawa M., Wong R.W., Todo T., Hirao A., Hinoi E. (2021) ,CDK8 maintains stemness andtumorigenicity of glioma stem cells by regulating the c-MYC pathway, Oncogene 40 2803-2815[259]

Ochiai S., Tokumura K., Park G., Ozaki K., Horie T., Yamada T., Iwahashi S., Ohta K., Fusawa H.,

Okayama Y., Kaneda K., Iezaki T., Hinoi E. (2021) ,Daily oral supplementation of Hochu-Ekki-To
prevents osteoclastic activation and bone loss in ovariectomized mice, Journal of Pharmacological Sciences
145 1-5
DM-06
[260]

Le P.Q., Awasthi S.P., Hatanaka N., Hinenoya A., Hassan J., Ombarak R.A., Iguchi A., Tran N.T.T.,

Dao K.V.T., Vien M.Q., Le H.X., Do H.T., Yamamoto Y., Yamasaki S. (2021) ,Prevalence of mobile
colistin resistance (mcr) genes in extended-VSHFWUXPȕ-lactamase-producing Escherichia coli isolated fromretail raw foods in Nha Trang, Vietnam, International Journal of Food Microbiology 346 109164

[261]

Kawahara R., Yamaguchi T., Yamamoto Y. (2021) ,Comparative genome analysis of livestock andhuman colistin-resistant escherichia coli isolates from the same household, Infection and Drug Resistance
14 841-847[262]

Nguyen T.N., Khong D.T., Le H.V., Tran H.T., Phan Q.N., Le H.T.T., Kawahara R., Yamamoto Y.

(2021) ,Quantitative Analysis of Colistin-Resistant Escherichia coli in Retail Meat from Local Vietnamese
Markets, BioMed Research International 2021 6678901
RY-01
[263]

Li M., Hieno A., Motohashi K., Suga H., Kageyama K. (2021) ,Pythium intermedium, a species

complex consisting of three phylogenetic species found in cool-temperate forest ecosystems, Fungal
Biology 125 1017-1025[264]

Afandi A., Subandiyah S., Wibowo A., Hieno A., Afandi, Loekito S., Suga H., Kageyama K.

(2021) ,Population genetics analysis of phytophthora nicotianae associated with heart rot in pineapple
revealed geneflow between population, Biodiversitas 22 3342-3348[265]

Hieno A., Li M., Otsubo K., Suga H., Kageyama K. (2021) ,Multiplex LAMP detection of the genus

phytophthora and four phytophthora species P. Ramorum, P. lateralis, P. kernoviae, and P. nicotianae,
with a plant internal control, Microbes and Environments 36 ME21018[266]

Jung T., Jung M.H., Webber J.F., Kageyama K., Hieno A., Masuya H., Uematsu S., Pérez-Sierra A.,+DUULV$5)RUVWHU-5HHV+6FDQX%3DWUD6.XGOiþHN7-DQRXãHN-&RUFREDGR70LOHQNRYLüI., Nagy Z., Csorba I., Bakonyi J., Brasier C.M. (2021) ,The destructive tree pathogen phytophthora
ramorum originates from the laurosilva forests of east asia, Journal of Fungi 7 226[267]૥໼‫ܡ‬୉ɾೖ‫ܛ‬໼҃ߵɾਤծ੘‫ٳ‬ɾ‫( ್߀ࢃܢ‬2021) Pythium aphanidermatum ͶΓΖϒʖϜϱࠞෙබʤ৿সʥɿೖຌ৪෼බཀྵָճๅ, 87(2): 80-83
RY-02
[268]

WenjiaoLi, JiefengLi, SartajAhmad Bhat, YongfenWei, ZhiyiDeng, FushengLi (2021) ,Eliminationof antibiotic resistance genes from excess activated sludge added for effective treatment of fruit andvegetable waste in a novel vermireactor, Bioresource Technology 325 124695[269]

Wenjiao Li, Haoning Su, Jiefeng Li, Sartaj Ahmad Bhat, Guangyu Cui, Zaw Min Han, Diva Sagita

Nadya, Yongfen Wei, Fusheng Li (2021) ,Distribution of extracellular and intracellular antibiotic resistancegenes in sludge fractionated in terms of settleability, Science of the Total Environment 760 143317
HA-01
[270]

Nagai R., Sugimachi A., Tanimoto Y., Suzuki K.G.N., Hayashi F., Weikert D., Gmeiner P., Kasai

R.S., Morigaki K. (2021) ,Functional Reconstitution of Dopamine D2 Receptor into a Supported Model
Membrane in a Nanometric Confinement, Advanced Biology 5 2100636



HA-02[271]

Kawade H., Morise J., Mishra S.K., Tsujioka S., Oka S., Kizuka Y. (2021) ,Tissue-specific regulationof hnk-1 biosynthesis by bisecting glcnac, Molecules 26 5176
[272]

Ohkawa Y., Kizuka Y., Takata M., Nakano M., Ito E., Mishra S.K., Akatsuka H., Harada Y.,

7DQLJXFKL1  3HSWLGHVHTXHQFHPDSSLQJDURXQGELVHFWLQJJOFQDFဨEHDULQJQဨJO\FDQVLQPRXVHEUDLQInternational Journal of Molecular Sciences 22 8579
[273]

Hirata T., Kizuka Y. (2021) ,N-Glycosylation, Advances in Experimental Medicine and Biology 1325

3-24
[274]

Kitano M., Kizuka Y., Sobajima T., Nakano M., Nakajima K., Misaki R., Itoyama S., Harada Y.,

Harada A., Miyoshi E., Taniguchi N. (2021) ,Rab11-mediated post-Golgi transport of the sialyltransferase
ST3GAL4 suggests a new mechanism for regulating glycosylation, Journal of Biological Chemistry 296
100354[275]

Hashimoto M., Fukamizu A., Nakagawa T., Kizuka Y. (2021) ,Roles of protein arginine

methyltransferase 1 (PRMT1) in brain development and disease, Biochimica et Biophysica Acta - General
Subjects 1865 129776
LS-02
[276]

Geiser D.M., Al-Hatmi A.M.S., Aoki T., Arie T., Balmas V., Barnes I., Bergstrom G.C.,

Bhattacharyya M.K., Blomquist C.L., Bowden R.L., Brankovics B., Brown D.W., Burgess L.W., Bushley
K., Busman M., Cano-Lira J.F., Carrillo J.D., Chang H.-X., Chen C.-Y., Chen W., Chilvers M., Chulze S.,
Coleman J.J., Cuomo C.A., Wilhelm de Beer Z., Sybren de Hoog G., Castillo-Munera J.D., Del Ponte E.M.,
Dieguez-Uribeondo J., Pietro A.D., Edel-Hermann V., Elmer W.H., Epstein L., Eskalen A., Esposto M.C.,
Everts K.L., Fernandez-3DYÕD63GD6LOYD*))RURXG1$)RXULH*)UDQGVHQ5-1)UHHPDQ6
Freitag M., Frenkel O., Fuller K.K., Gagkaeva T., Gardiner D.M., Glenn A.E., Gold S.E., Gordon T.R.,
Gregory N.F., Gryzenhout M., Guarro J., Gugino B.K., Gutierrez S., Hammond-Kosack K.E., Harris L.J.,
Homa M., Hong C.-F., Hornok L., Huang J.-W., Ilkit M., Jacobs A., Jacobs K., Jiang C., del Mar JimenezGasco M., Kang S., Kasson M.T., Kazan K., Kennell J.C., Kim H.-S., Corby Kistler H., Kuldau G.A.,
Kulik T., Kurzai O., Laraba I., Laurence M.H., Lee T., Lee Y.-W., Lee Y.-H., Leslie J.F., Liew E.C.Y.,
Lofton L.W., Logrieco A.F., Lopez-Berges M.S., Luque A.G., Lysøe E., Ma L.-J., Marra R.E., Martin F.N.,
May S.R., McCormick S.P., McGee C., Meis J.F., Migheli Q., Mohamed Nor N.M.I., Monod M., Moretti$0RVWHUW'0XOH*0XQDXW)0XQNYROG*31LFKROVRQ31XFFL02¶'RQQHOO.3DVTXDOL0
Pfenning L.H., Prigitano A., Proctor R.H., Ranque S., Rehner S.A., RHS05RGUÕJXH]-Alvarado G., Rose
L.J., Roth M.G., Ruiz-Roldan C., Saleh A.A., Salleh B., Sang H., Scandiani M.M., Scauflaire J., Schmale
D.G., Short D.P.G., Sisic A., Smith J.A., Smyth C.W., Son H., Spahr E., Stajich J.E., Steenkamp E.,
Steinberg C., Subramaniam R., Suga H., Summerell B.A., Susca A., Swett C.L., Toomajian C., Torres-Cruz T.J., Tortorano A.M., Urban M., Vaillancourt L.J., Vallad G.E., van der Lee T.A.J., Vanderpool D.,
van Diepeningen A.D., Vaughan M.M., Venter E., Vermeulen M., Verweij P.E., Viljoen A., Waalwijk C.,
Wallace E.C., Walther G., Wang J., Ward T.J., Wickes B.L., Wiederhold N.P., Wingfield M.J., Wood
A.K.M., Xu J.-R., Yang X.-B., Yli-Mattila T., Yun S.-H., Zakaria L., Zhang H., Zhang N., Zhang S.X.,
Zhang X. (2021) ,Phylogenomic analysis of a 55.1-kb 19-gene dataset resolves a monophyletic Fusarium
that includes the fusarium solani species complex, Phytopathology 111 1064-1079[277]

Ahsan N., Marian M., Suga H., Shimizu M. (2021) ,Lysinibacillus xylanilyticus strain gic41 as apotential plant biostimulant, Microbes and Environments 36 ME21047[278]

Li F.J., Suga H. (2021) ,Various methods for controlling the bakanae disease in rice, Reviews inAgricultural Science 9 195-205[279]

Sultana S., Bao W.X., Shimizu M., Kageyama K., Suga H. (2021) ,Frequency of three mutations in

the fumonisin biosynthetic gene cluster of Fusarium fujikuroi that are predicted to block fumonisin
production, World Mycotoxin Journal 14 49-59[280]

Li M., Hieno A., Motohashi K., Suga H., Kageyama K. (2021) ,Pythium intermedium, a species

complex consisting of three phylogenetic species found in cool-temperate forest ecosystems, Fungal
Biology 125 1017-1025[281]

Afandi A., Subandiyah S., Wibowo A., Hieno A., Afandi, Loekito S., Suga H., Kageyama K.

(2021) ,Population genetics analysis of Phytophthora nicotianae associated with heart rot in pineapple
revealed geneflow between population, Biodiversitas 22 3342-3348[282]

Hieno A., Li M., Otsubo K., Suga H., Kageyama K. (2021) ,Multiplex LAMP detection of the genus

Phytophthora and four Phytophthora species P. ramorum, P. lateralis, P. kernoviae, and P. nicotianae, witha plant internal control, Microbes and Environments 36 ME21019[283]

Bao W.X., Inagaki S.,Tatebayashi S., Sultana S., Shimizu M., Kageyama K., Suga H. (2021) ,Expression difference of P450–1 and P450–4 between G- and F-groups of Fusarium fujikuroi, European
Journal of Plant Pathology 159 27-36[284]

Bao W.X., Suga H. (2021) ,Genetic background of variable gibberellin production in the Fusarium

fujikuroi species complex, Reviews in Agricultural Science 9 32-42[285]

Sultana S., Suga H. (2021) ,Genetic background of variable fumonisin production in the Fusarium

fujikuroi species complex, Reviews in Agricultural Science 9 43-55[286]

૥໼‫ܡ‬୉, ೖ‫ܛ‬໼҃ߵ, ਤծ੘‫ٳ‬, ‫( ್߀ࢃܢ‬2021), Pythium aphanidermatum ͶΓΖϒʖϜϱࠞෙබ(৿স), ೖຌ৪෼බཀྵָճๅ 87 80-83

LS-03[287]

Shimozawa N., Takashima S., Kawai H., Kubota K., Sasai H., Orii K., Ogawa M., Ohnishi H.

(2021) ,Advanced diagnostic system and introduction of newborn screening of adrenoleukodystrophy andperoxisomal disorders in Japan, International Journal of Neonatal Screening 7 58
[288]

Takashima S., Takemoto S., Toyoshi K., Ohba A., Shimozawa N. (2021) ,Zebrafish model of human

Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene
expression changes, Molecular Genetics and Metabolism 133 307-323[289]

Kubota K., Kawai H., Takashima S., Shimohata T., Otsuki M., Ohnishi H., Shimozawa N.

(2021) ,Clinical evaluation of childhood cerebral adrenoleukodystrophy with balint's symptoms, Brain andDevelopment 43 396-401[290]

Fujiwara Y., Hama K., Shimozawa N., Yokoyama K. (2021) ,Glycosphingolipids with very long-

chain fatty acids accumulate in fibroblasts from adrenoleukodystrophy patients, International Journal of
Molecular Sciences 22 8645
[291]

Koto Y., Sakai N., Lee Y., Kakee N., Matsuda J., Tsuboi K., Shimozawa N., Okuyama T., Nakamura

K., Narita A., Kobayashi H., Uehara R., Nakamura Y., Kato K., Eto Y. (2021) ,Prevalence of patients withlysosomal storage disorders and peroxisomal disorders: A nationwide survey in Japan, Molecular Genetics
and Metabolism 133 277-288[292]

Morita M., Kaizawa T., Yoda T., Oyama T., Asakura R., Matsumoto S., Nagai Y., Watanabe Y.,

Watanabe S., Kobayashi H., Kawaguchi K., Yamamoto S., Shimozawa N., So T., Imanaka T. (2021) ,Bonemarrow transplantation into Abcd1-deficient mice: Distribution of donor derived-cells and biologicalcharacterization of the brain of the recipient mice, Journal of Inherited Metabolic Disease 44 718-727[293]

Kato K., Yabe H., Shimozawa N., Adachi S., Kurokawa M., Hashii Y., Sato A., Yoshida N., Kaga M.,

Onodera O., Kato S., Atsuta Y., Morio T. 2022 ,Stem cell transplantation for pediatric patients withadrenoleukodystrophy: A nationwide retrospective analysis in Japan, Pediatric Transplantation 26 e14125
LS-05
[294]

Shimaoka H., Shiina T., Suzuki H., Horii Y., Horii K., Shimizu Y. (2021) ,Successful induction ofdeep hypothermia by isoflurane anesthesia and cooling in a non-hibernator, the rat, Journal of Physiological
Sciences 71 10[295]

Horii K., Ehara Y., Shiina T., Naitou K., Nakamori H., Horii Y., Shimaoka H., Saito S., Shimizu Y.

(2021) ,Sexually dimorphic response of colorectal motility to noxious stimuli in the colorectum in rats,
Journal of Physiology 599 1421-1437

LS-06[296]

Sano H., Wakui A., Kawachi M., Washio J., Abiko Y., Mayanagi G., Yamaki K., Tanaka K.,

Takahashi N., Sato T. (2021) ,Profiling system of oral microbiota utilizing polymerase chain reactionrestriction fragment length polymorphism analysis, Journal of Oral Biosciences 63 292-297[297]

Wakui A., Sano H., Hirabuki Y., Kawachi M., Aida A., Washio J., Abiko Y., Mayanagi G., Yamaki

K., Tanaka K., Takahashi N., Sato T. (2021) ,Profiling of microbiota at the mouth of bottles and inremaining tea after drinking directly from plastic bottles of tea, Dentistry Journal 9 58
[298]

Wakui A., Sano H., Kawachi M., Aida A., Takenaka Y., Yonezawa A., Nakahata N., Moriyama S.,

Nishikata M., Washio J., Abiko Y., Mayanagi G., Yamaki K., Sakashita R., Tanaka K., Takahashi N., SatoT. (2021) ,Bacterial concentration and composition in liquid baby formula and a baby drink consumed withan artificial nipple, Journal of Oral Biosciences 63 161-168[299]

Tomida J., Akiyama-Miyoshi T., Tanaka K., Hayashi M., Kutsuna R., Fujiwara N., Kawamura Y.

(2021) ,Fusobacterium watanabei sp. nov. As additional species within the genus Fusobacerium, isolated
from human clinical specimens, Anaerobe 69 102323[300]

Vu H., Hayashi M., Nguyen T.N.,Kong D.T., Tran H.T., Yamamoto Y., Tanaka T. (2021) ,Comprisonof phenotypic and genotypic patterns of antimicrobial-resistant Bacteroides fragilis group isolated fromhealthy individual in Vietnam and Japan, Infection and Drug Resistance 14 5313
LS-07
[301]

Izawa S., Uchida K., Nakamura M., Fujimoto K., Roudin J., Lee J.-H., Inuzuka T., Nakamura T.,

Sakamoto M., Nakayama Y., Hiramoto M., Takahashi M. (2021) ,Influence of N-Substituents on
Photovoltaic Properties of Singly Bay-Linked Dimeric Perylene Diimides, Chemistry - A European Journal
27 14081-14091[302]

Sengoku T., Ogawa D., Iwama H., Inuzuka T., Yoda H. (2021) ,A heavy-metal-free desulfonylative

Giese-type reaction of benzothiazole sulfones under visible-light conditions, Chemical Communications
57 9858-9861[303]

Fujimoto K., Takimoto S., Masuda S., Inuzuka T., Sanada K., Sakamoto M., Takahashi M.

(2021) ,5,11-Diazadibenzo[hi,qr]tetracene: Synthesis, Properties, and Reactivity toward Nucleophilic
Reagents, Chemistry - A European Journal 27 8951-8955[304]

Kawazoe Y., Itakura Y., Inuzuka T., Omura S., Uemura D. (2021) ,Structure–activity relationshipstudy of the anti-obesity natural product yoshinone A, Chirality 33 226-232[305]

Fujimoto K., Izawa S., Takahashi A., Inuzuka T., Sanada K., Sakamoto M., Nakayama Y., Hiramoto

M., Takahashi M. (2021) ,Curved Perylene Diimides Fused with Seven-Membered Rings, Chemistry - An
Asian Journal 16 690-695

[306]

Funabiki K., Yamada K., Matsueda H., Arisawa Y., Agou T., Kubota Y., Inuzuka T., Wasada H.

(2021),Perfluorophenyl-Perfluorophenyl

Stacking-Promoted

Aggregation-Induced

Emission

Enhancement of Crystalline 5-Aryloxy-3H-Indole, European Journal of Organic Chemistry 2021 13441350[307]

Funabiki K., Gotoh T., Kani R., Inuzuka T., Kubota Y. (2021) ,Highly diastereo- And enantioselective

organocatalytic synthesis of trifluoromethylated erythritols based on thein situgeneration of unstable
trifluoroacetaldehyde, Organic and Biomolecular Chemistry 19 1296-1304
LS-08
[308]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Kitamura Y., Shimizu K., Okada A., Inoshima

Y. (2021) ,Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected
cattle, Scientific Reports 11 2951
[309]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Shimizu K., Okada A., Inoshima Y.

(2021) ,Putative internal control genes in bovine milk small extracellular vesicles suitable for normalizationin quantitative real time-polymerase chain reaction, Membranes 11 933[310]

Rahman M.M., Takashima S., Kamatari Y.O., Shimizu K., Okada A., Inoshima Y.

(2021) ,Comprehensive proteomic analysis revealed a large number of newly identified proteins in thesmall extracellular vesicles of milk from late-stage lactating cows, Animals 11 2506
[311]

Hirata Y., Motoyama M., Kimura S., Takashima M., Ikawa T., Oh-hashi K., Kamatari Y.O.

(2021) ,Artepillin C, a major component of Brazilian green propolis, inhibits endoplasmic reticulum stressand protein aggregation, European Journal of Pharmacology 912 174572[312]

Tanaka N., Kimura S., Kamatari Y.O., Nakata K., Kobatake Y., Inden M., Yamato O., Urushitani M.,

Maeda S., Kamishina H. (2021) ,In vitro evidence of propagation of superoxide dismutase-1 protein
aggregation in canine degenerative myelopathy, Veterinary Journal 274 105710
LS-09
[313]

Ma P., Takashima S., Fujita C., Yamada S., Oshima Y., Cai H.-L., Yurimoto H., Sakai Y., Hayakawa

T., Shimada M., Ning X., Wei B., Nakagawa T. (2021) ,Fatty acid composition of the methylotrophic yeast
Komagataella phaffii grown under low- and high-methanol conditions, Yeast 38 541-548[314]

Maeda M., Suzuki M., Takashima S., Sasaki T., Oh-Hashi K., Takemori H. (2021) ,The new live

imagers MitoMM1/2 for mitochondrial visualization, Biochemical and Biophysical ResearchCommunications 562 50-54[315]

Tanabe K., Takashima S., Iida H. (2021) ,Changes in the gene expression in mouse astrocytes inducedby pulsed radiofrequency: A preliminary study, Neuroscience Letters 742 135536

[316]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Kitamura Y., Shimizu K., Okada A., Inoshima

Y. (2021) ,Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected
cattle, Scientific Reports 11 2951
[317]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Shimizu K., Okada A., Inoshima Y.

(2021) ,Putative internal control genes in bovine milk small extracellular vesicles suitable for normalizationin quantitative real time-polymerase chain reaction, Membranes 11 933[318]

Rahman M.M., Takashima S., Kamatari Y.O., Shimizu K., Okada A., Inoshima Y.

(2021) ,Comprehensive proteomic analysis revealed a large number of newly identified proteins in thesmall extracellular vesicles of milk from late-stage lactating cows, Animals 11 2506
[319]

Shimozawa N., Takashima S., Kawai H., Kubota K., Sasai H., Orii K., Ogawa M., Ohnishi H.

(2021) ,Advanced diagnostic system and introduction of newborn screening of adrenoleukodystrophy andperoxisomal disorders in Japan, International Journal of Neonatal Screening 7 58
[320]

Takashima S., Takemoto S., Toyoshi K., Ohba A., Shimozawa N. (2021) ,Zebrafish model of human

Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene
expression changes, Molecular Genetics and Metabolism 133 307-323[321]

Kubota K., Kawai H., Takashima S., Shimohata T., Otsuki M., Ohnishi H., Shimozawa N.

(2021) ,Clinical evaluation of childhood cerebral adrenoleukodystrophy with balint's symptoms, Brain andDevelopment 43 396-401[322]

Okamoto H., Muraki I., Okada H., Tomita H., Suzuki K., Takada C., Wakayama Y., Kuroda A.,

Fukuda H., Kawasaki Y., Nishio A., Matsuo M., Tamaoki Y., Inagawa R., Takashima S., Taniguchi T.,
Suzuki A., Suzuki K., Miyazaki N., Kakino Y., Yasuda R., Fukuta T., Kitagawa Y., Miyake T., Doi T.,
Yoshida T., Yoshida S., Ogura S. (2021) ,Recombinant Antithrombin Attenuates Acute Respiratory
Distress Syndrome in Experimental Endotoxemia, American Journal of Pathology 191 1526-1536㸦㸧௧࿴  ᖺᗘእ㒊㈨㔠㈉⊩ᐇ⦼

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ઃৱϨθϞ͹੏‫ޜ‬ϟΩωθϞ͹մ໎0'୉ୖ‫ؿڣ‬‫خ‬൭‫& ڂݜ‬৿‫و‬ਚ৙੓പ൙ϠυϩϜΤη͹ࡠ੣ͳപ൙൅঳‫ؽ‬঄͹մ໎0'୉ୖ‫ؿڣ‬

γϱφϨʖਫ਼ໍՌָࡔ
஄αϨϱࡠಊ੓ߑ੔གྷોրรϜΤη͹ௐͶ͕͜Ζ‫ؽ‬೵մੵ

0'

घ௫݊Ҳ
৏Ԯ‫װ‬

Ռָ‫ڂݜ‬ඇঁ੔ࣆ‫ۂ‬ேકద‫ڂݜ‬ʤ๘լʥ೗ࣅࣅਹࡋ๖Ν༽͏ͪ +/$ ΰόϞրร L36 ࡋ๖ηφρέ͹ߑ஛

0'

઴ઔ༺Ҳ

‫خ‬൭‫ ڂݜ‬%߇ϜϧϨΠ༂ࡠ༽‫ؽ‬঄Ͷ͕͜Ζॕक໖Ӻ‫ߑؽ‬͹ༀׄ͹մ໎

0'

Ԯీӵࢦ

‫خ‬൭‫ ڂݜ‬%࣯ؔӹഋᔖ‫ߑؽ‬Ͷ͖͖ΚΖ݄؇಼ൿήϨαΩϨρέη͹‫ؽ‬೵մ
ੵ

0'

ӮҬ޼ध

‫خ‬൭‫ ڂݜ‬%7QVHT Ν‫ͪ͢༽׈‬ϪζΨϋϧබ‫ݬ‬੓‫ڂݜ‬͹৿ఴ֋

0'

ӮҬ޼ध

৿ָढ़྘Ү‫ڂݜ‬ʤ‫ݜ‬‫྘ڂ‬Ү఑Ҍ‫ܗ‬ʥΠϟʖώΝΌ͛Ζϛηφαρϙඏਫ਼෼ਫ਼ସָ

(*

ԥઔཾࢦ

Ռָ‫ڂݜ‬ඇึঁۜ‫خ‬൭‫& ڂݜ‬৙ԻͲਫ਼үͤΖϟνϱਫ਼੔ΠʖΫΠΝ‫ͪ͢༽׈‬ೋ߻੔νϱϏέ࣯ࢊਫ਼‫ܧ‬͹֋൅

(*

ቒ

Һ‫װ‬

(*

ቒ

Һ‫װ‬

ޮӻࡔ஄๑ਕෲ෨ๅޮճ ޽ָ‫ڂݜ‬ওྯԋঁۜޮӻࡔ஄๑ਕԗ౽੬
࣑࿗‫ى‬೨Ռָٗढ़৾
‫ࡔڷ‬஄ΩϨΤϞϙϠΦόϧʖφ౵ՃରΝཤ༽ͤΖ EϓϩΨϫίφϱ͹
৿‫߻و‬੔๑͹֋൅ΠϨϩΠϩαʖϩΝίφϱͶร‫ͤ׷‬Ζްིద͵ৰഖ‫ܧ‬͹֋൅



ౌ࿧൬ߺ

ࢱ໌

‫ڂݜ‬झ໪͵ʹ‫ڂݜ‬՟ୌ໌

Һ‫װ‬ޮӻࡔ஄๑ਕঘઔՌ
ָٗढ़ࡔ஄ΫϧϩΩϨΤϞԚ‫خ‬ৰഖΝ༽͏Ζ෈੬‫؂‬ԿൕԢ͹֋൅

(*

ቒ

(*

઩ӬҲਜ਼

‫خ‬൭‫& ڂݜ‬ॊཔາཤ༽͵੼֐ޭͲ൅ుͤΖಃ໎ଢཇుஓ͹߶੓೵Կ

(*

න կহ

ೖຌָढ़৾‫ڷ‬ճʀՌָ‫ڂݜ‬ඇঁ੔ࣆ‫ۂ‬‫خ‬൭‫& ڂݜ‬ঘ෾ࢢ͵‫ޭܮ‬੓Կ߻෼͹֋൅ͳࣅबබۗ͹‫ޭܮ‬ϕϫʖϔ૓੣

(*

઩ӬҲਜ਼

‫ڠ‬ಋ‫ڂݜ‬ʤ̐ऀʥ

(*

ࣴీ҃

‫خ‬൭‫& ڂݜ‬

PL51$ ͹ਫ਼ࡋ๖಼‫ݗ‬ड़Νࢨ޴ͪ͢ԿָൕԢϕϫʖϔ͹֋൅

(*

᠇᠃ग

ࠅࡏ‫ڠ‬ಋ‫ڂݜ‬Յଐ‫ۜخ‬ʤࠅࡏ‫ڠ‬ಋ‫کڂݜ‬Կ% ʥ഑Ԏ੏‫ޜ‬͹ͪΌ͹৿ોࡒ֋൅‫ڂݜ‬

(*

᠇᠃ग

‫ڠ‬ಋ‫ڂݜ‬ߜಀੁ͹੔෾෾ੵͳ༙ް੔෾͹Ԣ༽ Ͷ‫ͤؖ‬Ζ‫ڂݜ‬

(*

ԮՈԟ

‫خ‬൭‫& ڂݜ‬৿‫و‬χϝόൕԢΝ༽͏Ζଡ஖‫෈׷‬๠࿪‫؂‬য়୺Կਭો͹ཱིରમ୔ద߻੔๑͹֋൅

(*୉‫ݓڰ‬ଢ࿢

ேકద‫ڂݜ‬ʤ๘լʥ೶࿟ԿͶ‫ؖ‬ΚΖঘ๖ରમ୔దΨʖφϓΟζʖ‫࣯خ‬͹୵ࡩͳਈ‫ܨ‬࿟Կ੏‫΃ޜ‬͹Ԣ༽(*୉‫ݓڰ‬ଢ࿢

‫خ‬൭‫ ڂݜ‬%βϩζରηφϪηεήψϩͶ஥໪ͪ͢৿ͪ͵࿟೧බ൅঳ϟΩω
θϞ͹մੵ

$*

ౣీথ໷

‫خ‬൭‫& ڂݜ‬$*ਭ୫࿪ਕɼ৏
⁍‫ٳ‬ෆʤਁྜྷ
‫ॶڂݜ‬ʥɼྵ
໨࢛࿗ʤ‫ز‬෠୉ʥ،ଃࢹ࣯େः͹ΦϒΰόϞ੏‫ޜ‬Ͷ஥໪ͪ͢Վ౸༢಍੓ࢹ๳،ͳ
ͨ͹༩๹Ͷ‫ͤؖ‬Ζ‫خ‬൭‫ڂݜ‬‫ڠ‬ಋ‫ڂݜ‬‫ޫـ‬รಊ౵ͶଲԢͤΖͪΌ͹Ϋόαਫ਼ࢊ؇ཀྵٗढ़͹֋൅

$*

ཚ߻ਜ਼ध

ೖຌָढ़৾‫ڷ‬ճ
घ‫ڂݜ‬

$*

ཚ߻ਜ਼ध

ਁԾਖ୰‫ࣞה‬ճऀ‫ڠ‬ಋ‫ڂݜ‬

$*

஦ઔಬ

‫خ‬൭‫& ڂݜ‬Ն༻‫ܗ‬ʤϕϫʥϪωϱण༲ର‫ؽ‬೵͹ࡋ๖֐ϠζϣϪʖεϥϱ‫ؽ‬
ߑ͹մ໎

$*

‫ڰ‬ຌඔྍ

$*‫ڰ‬ຌඔྍ

$*‫ڰ‬ຌඔྍ

ೖຌָढ़৾‫ڷ‬ճՌ‫ݜ‬ඇ ऑघ‫ڂݜ‬$*‫ڰ‬ຌඔྍ

ޮӻࡔ஄๑ਕ Ҷ੟ࡔ஄  Ҷ੟‫ঁڂݜ‬੔

$*

ঘࢃദ೯

‫خ‬൭‫ ڂݜ‬%࢐੓ౖৗʀ‫ף‬૫ʀ‫ץ‬ਭଳ੓Νଡ໚੏‫ͤޜ‬Ζ 6723 εητϞ͹
਒Կଡ༹੓

$*

ௗԮཤ

‫خ‬൭‫ ڂݜ‬$ৱ඾νϱϏέ࣯༟པ͹ࢹ࣯େःրવϘϕοχ͹ຌ࣯దཀྵմͳַ
৿దԢ༽Ͷ‫ͤؖ‬Ζ‫خ‬൭‫ڂݜ‬ʤେනʥ$*৕ϴ‫يݬ‬௪ಢཱིߨ੕๑ਕ‫࠸ڧ؂‬ਫ਼ฯસ‫ߑؽ‬ʀ‫ڂݜڧ؂‬૱߻ਬ਒ඇ৷ྲྀద֐པᄣ೗ྪ͹๹ঈ੕ࡨ݀ఈϕϫιη͹ͪΌ͹ଲࡨٗढ़͹
߶ౕԿ

$*

ᕈ໼‫ݲ‬

Ռ‫ݜ‬ඇʀ‫خ‬൭‫& ڂݜ‬Πϧ΢ήϜͳϜϱήʖηΝϠυϩͶͪ͢৷ྲྀద֐པᄣ೗ྪࠞઊ
͹ͪΌ͹ඈೝϭέοϱ֋൅ऑྫ࿪̑೧ౕ࿊೸‫ڂݜ‬ήϩʖϕ‫ܙ‬੔ࢩԋࣆ‫ۂ‬ʤຌָʥ
ྫ࿪̑೧ౕ࿊߻೸ָ
‫ڂݜ‬Ռऑघ‫گ‬ҽү੔ࣆ‫ۂ‬ʤຌָʥ

ώϧިࡸॄ஄Ν༽͏ͪ՘঄͹෾ࢮ੓͹Ҫఽմੵঘ೶൅ୣΝۨಊͤΖΠϩάωϱϟοϩԿ‫࣯خ‬͹ಋఈʀ‫ؽ‬೵մੵ



ౌ࿧൬ߺ

ࢱ໌

‫ڂݜ‬झ໪͵ʹ‫ڂݜ‬՟ୌ໌

$*

઴ీఅय़

‫خ‬൭‫ ڂݜ‬%ίϠΩ΢ϱण༲ରΝඬదͳͪ͢‫ݚ‬͹ൿේ 7 ࡋ๖ϨϱϏञͶଲͤ
Ζַ৿ద࣑ྏ๑͹֋൅$*‫ٸ‬࿮৽‫ޙ‬‫خ‬൭‫ ڂݜ‬%ΰόϞฦॄϜΤηͶΓΖ‫ݚ‬͹Ҫఽ੓࣮‫ݬͳ׳‬ҾҪఽࢢʀଡ‫ܗ‬͹ҾՎ‫ܐؖ‬͹ࣰ‫ݩ‬దৄ໎$*‫ٸ‬࿮৽‫ޙ‬ேકద‫ڂݜ‬ʤ๘լʥௗ࠱ 51$ εʖίϱηͶΓΖ &U\SWLFH[RQ ͹୵ࡩ

$*

Ԯీ࠾Յ

޲ਫ਼࿓ಉՌָ‫ึڂݜ‬ঁۜʀৱ඾͹҈સ֮ฯਬ਒‫ۂࣆڂݜ‬৿‫و‬घ๑ͶΓΖৱ௙೓Ͷ͕͜ΖΩϱϒϫώένʖԜઝয়‫ڱ‬͹௒ࠬͶ‫ͤؖ‬Ζ‫ڂݜ‬

$*

Ԯీ࠾Յ

ޮӻࡔ஄๑ਕࢀౣք
Ӥ‫ى‬೨ࡔ஄

ৱ஦ಡ‫ݬ‬Ҿۗ &DPS\OREDFWHUMHMXQL ͹‫ٵ‬ເͶ‫ؖ‬ΚΖʰη΢ρ
οʱ͹ಋఈ

$*

Ԯీ࠾Յ

Ҳൢࡔ஄๑ਕ‫ظ‬Ӫճܴ೓Ͷ͕͜Ζਫ਼͘ͱ͏Ζ͗ക཈Ͳ͘͵͏Ωϱϒϫώένʖ͹‫ݗ‬ड़๏๑͹ཱི֮

$*

ࢦਭ଻෤

ேકద‫ ڂݜ‬๘լ౛ເಊ෼͹ಝ੓ΝҫྏԢ༽ͤΖͪΌ͹ਕ޽౛ເ༢൅Ͷ‫ͤؖ‬Ζ‫ݜ‬
‫ڂ‬

$*

ࢦਭ଻෤

‫خ‬൭‫ ڂݜ‬%஦਽ਈ‫ܨ‬ͶΓΖ୉ௐӣಊ੏‫ͳߑؽޜ‬ഋสҡ৙Ͷ೟ΌΔΗΖ੓ࠫ͹ϟΩωθϞմ໎

$*

ࢃ಼߅ਫ਼

ऑघ‫ڂݜ‬‫఺ؠ‬ҢΝ૏֒ͤΖϟοϩέΥϩιοϱ͹ࡠ༽‫ؽ‬঄͹մ໎$*஦ઔ‫ܡ‬ղ

ࢀౣքӤ‫ى‬೨ࡔ஄‫ݜ‬‫ঁڂ‬੔ਫ਼ϭέοϱ ֋൅Ν໪ࢨͪ͢‫ډ‬αϫψΤ΢ϩηҪఽࢢ૤ࡠ‫ܧ‬͹֮
ཱི

$*

஦ઔ‫ܡ‬ղ

ґ౽‫ى‬೨ࡔ஄‫ঁڂݜ‬੔΢όεεͶ͕͜Ζ಴αϫψΤ΢ϩηླྀߨࣰସ௒ࠬ

$*஦ઔ‫ܡ‬ղ

‫ز‬෠‫ݟ‬ʀҗ୙ࣆ‫ۂ‬‫ز‬෠‫ݟ‬Ͷ͕͜Ζܴఽઝ੓‫ـ‬؇ࢩԎ͹ਃ७௒ࠬ

$*

ෳ࢞ऴਕ

‫خ‬൭‫ ڂݜ‬%

$*

ෳ࢞ऴਕ

޲ਫ਼࿓ಉߨ੕ਬ਒௒
ࠬࣆ‫ۂ‬ඇึঁۜʤ৿
‫ڷ‬ʀ࠸‫״ڷ‬ઝ঳‫;ٶ‬༩๹ંझ੕ࡨਬ਒‫ݜ‬‫ۂࣆڂ‬ʥ

ϖϩϘηΤ΢ϩηͶΓΖ஗ࢰ੓೶Ԏ͹൅‫ߑؽݳ‬մ໎͕Γ;༩๹๑ཱི֮Ͷ޴ͪ͜‫ેخ‬ద‫ڂݜ‬

$*

ґ౽௜ਕ

‫خ‬൭‫ ڂݜ‬%

$*

ґ౽௜ਕ

ࠅࡏ‫ڠ‬ಋ‫ڂݜ‬Յଐ‫خ‬ۜ ࠅࡏ‫ڠ‬ಋ‫کڂݜ‬
Կ %

$*

߶ౣ߃߄

‫خ‬൭‫ ڂݜ‬%φΫλϕϧθϜɼϋΨηϛϧ͹ઞ෮͖Δ͹‫׈‬੓ԿΝ࢚Ζ෾ࢢϟΩωθϞ͹մ໎

$*

ࢃຌ࣑ٝ

‫خ‬൭‫& ڂݜ‬झ಼ψοϣϧϩώϨΦʖεϥϱΝ༽͏ͪ৪෼ϕϫϠʖνʖ͹਒Կదଈ໚͹մ໎

$*

༆ੋ঺ࢢ

‫خ‬൭‫& ڂݜ‬ߜண͹कགྷ͵‫ؽ‬೵੓Ν࢚ΖτΠϩϑζϱ͹ߑଆմ໎

$*

༆ੋ঺ࢢ

‫ڠ‬ಋ‫ڂݜ‬᷄޽৖‫ݬ‬ྋ༽๚ࢊ඾෯ࢊ෼͹༙ް‫༽׈‬Ͷ‫ͤؖ‬Ζ‫ڂݜ‬

$*

༆ੋ঺ࢢ

‫ڠ‬ಋ‫ ڂݜ‬Πϩϕη༂඾޽‫ה ۂ‬ϓϧϚό΢χ͹ϕϪώ΢ΨτΡέη‫ڂݜ‬

$*

༆ੋ঺ࢢ

‫ڠ‬ಋ‫ڂݜ‬Φϱη᷄ਫ਼ཀྵ‫׈‬੓ళષ෼͹ਫ਼෼༙‫ؽ‬Կָద‫ڂݜ‬

ೖ৿๚ຸ

ௗྒྷγ΢

Ѭ‫؟‬ಊ෼༟པ‫״‬ઝ঳੏‫ޜ‬͹ͪΌ͹ɼ‫״‬ઝ঳൅ਫ਼য়‫ڱ‬ɼ‫ݬ‬Ҿබ‫ݬ‬ର‫;ٶ‬ॕकಊ෼͹մੵͶ‫͚Ͱخ‬Ϩηέ඲Ճͳ‫ܔ‬൅Ͷ‫ͤؖ‬Ζ‫ڂݜ‬ʤ෾୴ʥ߶‫ౕ״‬͹‫״‬ઝࡋ๖‫ݗ‬ड़‫ܧ‬Ν༽͏ͪ‫ݚڲ‬බΤ΢ϩη͹຦঩‫״‬ઝಊସ͹մੵ࠹઎୼΢ϟʖζϱήٗढ़Ν‫ݚڲͪ͢༽׈‬බΤ΢ϩη໼֐‫ה‬͹຦঩‫״‬ઝ‫ؽ‬঄͹մ໎

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ౌ࿧൬ߺ

ࢱ໌

‫ڂݜ‬झ໪͵ʹ‫ڂݜ‬՟ୌ໌

$*

છҬర෋

‫خ‬൭‫ ڂݜ‬$ΰόϞմੵͳ਼ཀྵմੵΝ༽͏ͪಊ෼͹ऀճਫ਼‫׈‬ͶΓΖ༂ࡐଳ੓ۗ͹‫ڧ؂‬Ԝઝ͹մੵ$*ন‫ݬ‬ཇҲ

‫خ‬൭‫& ڂݜ‬ελՌ৪෼͹ࠠ৪ͶΓΖ৪෼ਫ਼ௗଇ਒‫ߑؽ‬մ໎‫و৿;ٶ‬৪෼੔ௗրવ๑΃͹Ԣ༽$*ন‫ݬ‬ཇҲޮࡔ Ӟ৏ৱ඾ʀৱ
ชԿ৾‫ࡔڷ‬஄ελՌύʖϔ  ࣏େः੔෾͹ϟνϚϫʖϞմੵ‫ؽ߶;ٶ‬೵ԿͶ‫ͤؖ‬Ζ‫ڂݜ‬$*ন‫ݬ‬ཇҲ

஦෨ుྙʤ‫ה‬ʥۗࠞۗ‫༽׈‬ͶΓΖ೸‫ڷ৾ۂ‬౵Ν௪ͣͪஏҮ߫‫ࡨݛ‬͹‫ݗ‬౾$*ք࿟‫ݬ‬হ࿢

$*ք࿟‫ݬ‬হ࿢

$*

ੜਭগช

‫خ‬൭‫ ڂݜ‬%༙༽ࠞ‫ॴۗࡋݏ‬ཀྵͶΓΕ৪෼Ͷ༢಍͠ΗΖ੪‫ޅ‬බۗഋঈ‫ݳ‬ে͹෾ࢢ‫ߑؽ‬մ໎

$*

஦ଞߔฑ

‫خ‬൭‫& ڂݜ‬੶་͹ϟνϱ൅߮ͶΓΖ੶་ଁ਒յफʷ&2 ϓϨʖਭો‫ݱڇڛ‬૓ड़͹Ն೵੓͹‫ৄݗ‬

$*

ஶౣ߃༦

‫خ‬൭‫ ڂݜ‬%ΦέλλʖϞ಼෾ࢢ͹‫ڏ‬ಊͳ‫ఽډ‬ઝ੓ϨϱϏञ൅঳ͳ͹‫ؖ‬࿊մ
໎

$*

୉੤݊෋

‫خ‬൭‫ ڂݜ‬%$*ೖ‫ת‬෤༡ྫ࿪  ೧ౕ ޮӻࡔ஄๑ਕ ґ౽‫ى‬೨ࡔ஄ ‫ঁڂݜ‬੔ࣆ‫ۂ‬ౖৗͶ͕͜Ζ࢐Կؒ‫ݫ‬ൕԢ͹௜ંద੏‫ޜ‬ͺՆ೵͖ʃʘͨ͹Ն೵੓ͳ‫ݸ‬ֆΝ୵Ζʘ߇࢐Կ෼࣯Νཤ༽ͪ͢Τεର֐ण੠ཝਫ਼ࢊٗढ़͹߶ౕԿͳͨΗΝԢ༽ͪ͢৿‫ و‬238,9)(7 ͶΓΖࢢ‫ډ‬ਫ਼ࢊεητϞ͹֋൅
ʤᶚʥ

'0

ฑౣҲٍ

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ฑౣҲٍ

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ஶౣ߃༦ʤେ
නʥ߶ౣໞ༦
ʤ෾୴ʥ୉‫ݓڰ‬ଢ࿢
ʤେනʥ߶ౣ
ໞ༦ʤ෾୴ʥ

޲ਫ਼࿓ಉՌָ‫ڂݜ‬ඇึঁۜʤೋ࣑੓࣮‫ࠂ׳‬ෲ‫ۂࣆڂݜ‬ʥʤ෾୴ʥ
ೖຌҫྏ‫֋ڂݜ‬൅‫ߑؽ‬੔ү࣮‫ࠂ׳‬ෲ౵૱߻‫ݜ‬‫ۂࣆڂ‬ʤ෾୴‫ंڂݜ‬ʥ಼౽‫ى‬೨Ռָ৾‫ࡔڷ‬஄ʀ಼౽‫ى‬೨ঃ੓‫ڂݜ‬ंঁ੔ۜεʖεʖΠ΢ϙʖϩυΡϱήη‫ࣞה‬ճऀʀεʖεʖΠ΢ϙʖϩυΡϱήη‫ঁڂݜ‬੔ϕϫήϧϞ‫ڂݜ‬՟ୌ໌

ϧ΢λμʖϞබɼϘϩΨΫελʖϞබʤ෯ਝപ࣯ζηφϫϓΡ
ʗΝ‫؜‬΋ʥͶ͕͜Ζྒྷ࣯͖ͯన઀͵ҫྏ͹ࣰ‫ݳ‬Ͷ޴ͪ͜ର੏͹ߑ஛ͳͨ͹ࣰૹͶ‫ͤؖ‬Ζ‫ڂݜ‬৿ਫ਼ࣉϜηηέϨʖωϱήଲে֨ै͹ͪΌ͹࣮‫׳‬મఈ‫خ‬६͹ཱི֮౛ເ༹Ҫఽࢢ൅‫ͳݳ‬উ֒ଳ੓Ͷ‫ͤؖ‬Ζ‫ڂݜ‬Ӗ佅໡૸ 6\PELRGLQLXPVS ͗ਫ਼ࢊͤΖಝҡ͵ߑଆΝ΍ͯ‫ؽ‬೵੓෼࣯͹୵ࡩ

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ࢤࣀ࣒◊✲ศ㔝ᩍဨࡢᩍ⫱◊✲άື➼ձ ᩍ⫱άື
኱Ꮫ㝔㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉㸦ୗ⃝㸧௦ㅰ⑓ែไᚚᏛ≉ㄽ་Ꮫ㒊㸦ୗ⃝㸧ࢸࣗࢺ࣮ࣜ࢔ࣝࠕᡂ⫱ࠖࢥ࣮ࢫᑠඣ⑓ែᏛ
㑇ఏᛶᑠඣ⚄⤒➽⑌ᝈ  ᫬㛫་Ꮫ㒊ࢸࣗࢺ࣮ࣜ࢔ࣝ㑅ᢥ㓄ᒓ㸦㧗ᓥࠊୗ⃝㸧㸰ྡࠊ 㐌㛫኱Ꮫ㝔㐃ྜ㎰Ꮫ◊✲⛉㸦㡲㈡㸧
୺࣭๪ᣦᑟᩍဨ
኱Ꮫ㝔⮬↛⛉Ꮫᢏ⾡◊✲⛉㸦㡲㈡㸧
ศᏊ᳜≀⑓Ꮫ≉ㄽ  ༢఩୺࣭๪ᣦᑟᩍဨ
ᛂ⏝⏕≀⛉Ꮫ㒊㸦㡲㈡㸧
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Ⓨ⏕㑇ఏᏛ  ᫬㛫኱Ꮫ㝔㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉㸦㧗ᓥ㸧
Ⓨ⏕㑇ఏᏛ≉ㄽ  ༢఩๪ᣦᑟᩍဨᏛእ࡛ࡢㅮ⩏࡞ࡋղ ◊✲άື
㸺Ꮫ⾡ㄽᩥ㸼
㸦࿴ᩥⴭ᭩㸧
࡞ࡋ㸦ⱥᩥཎⴭ㸧

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16. Morita M, Kaizawa T, Yoda T, Oyama T, Asakura R, Matsumoto S, Nagai Y, Watanabe Y, Watanabe S,
Kobayashi H, Kawaguchi K, Yamamoto S, Shimozawa N, So T, Imanaka T. Bone marrow transplantation
into Abcd1-deficient mice: Distribution of donor derived-cells and biological characterization of the brainof the recipient mice. J Inherit Metab Dis. 2021; 44(3): 718-727.
17. Kubota K, Kawai H, Takashima S, Shimohata T, Otsuki M, Ohnishi H, Shimozawa N. Clinical evaluationof childhood cerebral adrenoleukodystrophy with balint's symptoms. Brain Dev. 2021; 43(3): 396-401.
18. Takashima S, Takemoto S, Toyoshi K, Ohba A, Shimozawa N. Zebrafish model of human Zellweger
syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene
expression changes. Mol Genet Metab. 2021 May 8:S1096-7192(21)00703-4.
19. Koji Kato, Hiromasa Yabe, Nobuyuki Shimozawa, Souichi Adachi, Mineo Kurokawa, Yoshiko Hashii,
Atsushi Sato, Nao Yoshida, Makiko Kaga, Osamu Onodera, Shunichi Kato, Yoshiko Atsuta, and Tomohiro
Morio. Stem Cell Transplantation for Pediatric Patients with Adrenoleukodystrophy: A nationwide
retrospective analysis in Japan. Pediatric Transplantation. 2021 Oct 18;e14125.
㸦ⱥᩥ⥲ㄝ㸧

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㸦࿴ᩥ⥲ㄝ㸧
1.

ᕝྜ⿱つࠊஂಖ⏣୍⏕ࠊୗ⃝ఙ⾜. 㧗ḟ⬻ᶵ⬟㞀ᐖ࡛Ⓨ⑕ࡋࡓᑠඣ኱⬻ᆺ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡢ
᪩ᮇデ᩿ࡢࡓࡵࡢ⮫ᗋᏛⓗ᳨ウ. ᑠඣࡢ⢭⚄࡜⚄⤒ 61 (1) 35-41, 2021 ᖺ 4 ᭶2.

ୗ⃝ఙ⾜. 㑇ఏ⏕໬Ꮫ ⮫ᗋ㑇ఏᑓ㛛་ࢸ࢟ࢫࢺ㸯 ⮫ᗋ㑇ఏᏛ⥲ㄽ デ᩿࡜἞⒪♫. ᮾி. 2021 ᖺ7᭶

3.

ୗ⃝ఙ⾜. ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢᅜෆᑟධ࡟ྥࡅ࡚ࡢ⌧≧࡜ㄢ㢟. ≉㞟 ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ࡜἞⒪ࡢ᭱๓⥺. 㑇ఏᏊ་Ꮫ 11 (3) 80-87, 2021 ᖺ 7 ᭶4.

㧗ᓥⱱ㞝ࠊୗ⃝ఙ⾜. ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓࡟࠾ࡅࡿ⬡㉁௦ㅰ࡜἞⒪. The Lipid ≉㞟 ࢜ࣝ࢞ࢿࣛ࡜⬡㉁ Ѹᇶ♏࡜⮫ᗋ࠿ࡽѸ 32 (2) 76-84, 2021 ᖺ 10 ᭶

5.

ୗ⃝ఙ⾜. ABCD1㸦㛵㐃⑌ᝈ㸸๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮㸧 ᑠඣ⛉デ⒪ ≉㞟 ᑠඣ㑇ఏᏊ⑌ᝈ㎡඾ 84(11) 1511-1513, 2021 ᖺ 11 ᭶

6.

ୗ⃝ఙ⾜. ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ ⬻⚄⤒ෆ⛉デ᩿ࣁࣥࢻࣈࢵࢡ ୗ⏿஽Ⰻ⦅୰እ་Ꮫ♫. ᮾி.

2022 ᖺ 1 ᭶
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1.

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㎰ᯘỈ⏘┬ጤクࣉࣟࢪ࢙ࢡࢺ◊✲ ᅜ⏘㎰⏘≀୰ࡢ࠿ࡧẘཬࡧ࠿ࡧẘ㢮⦕యࡢືែゎ᫂୪ࡧ࡟ởᰁࡢ㜵Ṇཬࡧపῶ࡟㛵ࡍࡿ◊✲  ㄢ㢟㈐௵⪅ ࠕ'1$ ࢫࢺࣜࢵࣉ࡟ࡼࡿ㯏㢮㉥࠿ࡧ⑓⳦ࡢࢺࣜ
ࢥࢸࢭࣥẘ⣲ᆺ⡆ุ᫆ᐃἲࡢ㛤Ⓨࠖ  ༓෇㧗ᓥⱱ㞝௧࿴ඖᖺ̺ ᖺᗘ ⛉Ꮫ◊✲㈝⿵ຓ㔠ᇶ┙◊✲㸦&㸧 ◊✲௦⾲⪅ ࠕ⑌ᝈࣔࢹࣝࢆ⏝࠸ࡓ࣌ࣝ࢜࢟
ࢩࢯ࣮࣒ᙧᡂ␗ᖖ⑕Ⓨ⑕ᅉᏊࡢ≉ᐃࠖ㸦㸧᪂⪺ሗ㐨➼࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢデ⒪యไࢆ☜❧ࡍࡿࡲ࡛ࡢ◊✲άື ୗ⃝ఙ⾜࣒ࢥከ⢾ࣉࣟࢧ࢖ࢺྲྀᮦ࣏࣮ࣞࢺ
KWWSVPSVSURMFUMSUHSRUWUHSRUWBSKS
௨ୗ࡟ᥖ㍕ࠋ

࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢデ⒪యไࢆ☜❧ࡍࡿࡲ࡛ࡢ◊✲άືᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ࢤࣀ࣒◊✲ศ㔝ᩍᤵ

ୗ⃝ఙ⾜

ඛ⏕

࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡣ  ᖺ௦௨㝆࡟ཎᅉࡀ᫂ࡽ࠿࡟࡞ࡗࡓẚ㍑ⓗࠊ◊✲ࡢṔྐࡀὸ࠸⑌ᝈ࡛࠶ࡿࠋ
ᒱ㜧኱Ꮫࡢ◊✲ࢢ࣮ࣝࣉࡣୡ⏺࡟ඛ㥑ࡅ࡚ࡇࡢ⑌ᝈࡢ⑓ែゎ᫂ࢆ㐍ࡵ࡚ࡁࡓࡇ࡜࡛▱ࡽࢀ࡚࠸ࡿࠋྠࢢ
࣮ࣝࣉࡢ◊✲࡟ࡼࡾ⑌ᝈࡀㄆ▱ࡉࢀࠊ ᖺ࠿ࡽࡣ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡶጞࡲࡗࡓࠋ
ྠ኱Ꮫࡢୗ⃝ఙ⾜ඛ⏕࡟ୡ⏺ึࡢ⑓ᅉ㑇ఏᏊⓎぢ࠿ࡽデ⒪యไࡢ☜❧ࡲ࡛ࡢάືࢆ⪺ࡃࠋୗ⃝ఙ⾜ඛ⏕㸦᧜ᙳ㸸㉺㔝㱟ᙪࠊ௨ୗྠࡌ㸧ୗ⃝ඛ⏕ࡀ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ◊✲࡟╔ᡭࡋࡓࡢࡣ࠾ࡼࡑ  ᖺ๓ࡢ  ᖺࡢࡇ࡜ࡔࡗࡓࠋᒱ㜧኱Ꮫᑠඣ⛉࡟࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀḞᦆࡍࡿ =HOOZHJHU ⑕ೃ⩌㸦⬻⫢⭈⑕ೃ⩌ࠊࢶ࢙࣮ࣝ࣋࢞⑕ೃ⩌㸧ࡢ᪂⏕ඣࡀධ㝔ࡋࡓࡢࡀࡁࡗ࠿ࡅ࡛࠶ࡿࠋ
ᙜ᫬ࡣ⑌ᝈ⮬యࡀ࠶ࡲࡾ▱ࡽࢀ࡚࠾ࡽࡎࠊᙜึデ᩿ࡀ௜࠿࡞࠿ࡗࡓࡀࠊࡇࢀࢆዎᶵ࡟ୗ⃝ඛ⏕ࡢඛ㍮
ࡢ㕥ᮌᗣஅඛ⏕ࡀ⮫ᗋ◊✲ࢆࢫࢱ࣮ࢺࡋࠊୗ⃝ඛ⏕ࡶඹ࡟◊✲࡟ྲྀࡾ⤌ࡴࡇ࡜࡟࡞ࡗࡓࠋ
ࠕᙜ᫬ࡢᒱ㜧኱Ꮫᑠඣ⛉ࡢᩍᤵ࡛࠶ࡗࡓᢡᒃᛅኵඛ⏕ࡀඛኳ௦ㅰ␗ᖖࢆ୺࡞◊✲ࢸ࣮࣐࡜ࡋ࡚࠾ࡾࠊ
ࡑࡢ୰࡛ࡶࣛ࢖ࢯࢰ࣮࣒⑓࡛࠶ࡿ࣒ࢥከ⢾⑕ࡢ◊✲ࢆ㐍ࡵ࡚࠸ࡲࡋࡓࠋࡑࡢࡼ࠺࡞⫼ᬒ࠿ࡽࠊ࣌ࣝ࢜࢟

ࢩࢯ࣮࣒⑓ࡢ◊✲࡟ࡶ๓ྥࡁ࡟ྲྀࡾ㎸ࡳࡸࡍ࠸⎔ቃࡀ࠶ࡾࡲࡋࡓࠋࡉࡽ࡟ಙᕞ኱Ꮫࡢᶫᮏ㝯ඛ⏕ࡀ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢᇶ♏◊✲࡟ྲྀࡾ⤌ࢇ࡛࠾ࡾࠊᒱ㜧኱Ꮫࡀඹྠ◊✲ࢆጞࡵࡿࡇ࡜࡟࡞ࡾࡲࡋࡓࠖ࡜ୗ⃝ඛ⏕ࡣ᣺ࡾ㏉ࡿࠋࡑࡶࡑࡶ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡣ  ᖺ࡟࣑ࢡࣟ࣎ࢹ࢕࣮࡜࠸࠺ᙧ࡛Ⓨぢࡉࢀࠊ ᖺ࡟࣌ࣝ࢜࢟ࢩࢯ࣮
࣒࡜ྡ௜ࡅࡽࢀ࡚࠸ࡓࠋ
ࠕ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡣ⣽⬊ෆ࢜ࣝ࢞ࢿࣛ࡜࿧ࡤࢀࡿ⣽⬊ෆᑠჾᐁࡢ୍ࡘ࡛ࡍࠋࣛ࢖ࢯࢰ࣮࣒ࡸ࣑ࢺࢥ
ࣥࢻࣜ࢔࡜ẚ࡭ࡿ࡜◊✲ࡢṔྐࡀὸ࠸ࡓࡵ࡟⌧ᅾ࡟⮳ࡗ࡚ࡶ༑ศ࡟▱ࢀࢃࡓࡗ࡚࠸ࡲࡏࢇࠖ࡜ୗ⃝ඛ⏕ࡣㄝ᫂ࡍࡿࠋ
◊✲ࡢࡁࡗ࠿ࡅ࡟࡞ࡗࡓ =HOOZHJHU ⑕ೃ⩌ࡣ  ᖺ࡟ࠊ⬻ࠊ⫢⮚ࠊ⭈⮚࡟㞀ᐖࢆᣢࡘཎᅉ୙᫂ࡢᐙ᪘
ᛶ⑕ೃ⩌࡜ࡋ࡚ሗ࿌ࡉࢀࠊ⬻⫢⭈⑕ೃ⩌࡜ࡶ࿧ࡤࢀࡓࠋ
 ᖺ࡟ =HOOZHJHU ⑕ೃ⩌ࡢᝈඣࡢ⫢⣽⬊࡛࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀḞᦆࡋ࡚࠸ࡿ࡜ุ᫂ࡍࡿࠋࡓࡔࡋࠊ
ࡇࡢ࡜ࡁ࡟ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀ༑ศ࡟⌮ゎࡉࢀ࡚࠾ࡽࡎὀ┠ࡉࢀ࡞࠿ࡗࡓࠋ

㹺⛉Ꮫㄅࠕ6FLHQFH࡛ࠖୡ⏺ึࡢሗ࿌ ᖺࠊୗ⃝ඛ⏕ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊࡀ =HOOZHJHU ⑕ೃ⩌ࡢ⑓ᅉ㑇ఏᏊ࡛࠶ࡿࡇ࡜ࢆ✺ࡁṆࡵࠊ⛉Ꮫㄅࠕ6FLHQFH࡛ࠖୡ⏺ึࡢⓎ⾲ࢆࡋࡓࠋࡇࡢ◊✲⤖ᯝࡣୡ⏺ⓗ࡟ࡶ⏬ᮇⓗ࡞Ⓨぢ࡛࠶ࡾࠊᅜ
ෆእࡢ་⒪࡟࢖ࣥࣃࢡࢺࢆ୚࠼ࡓࠋ
ୗ⃝ඛ⏕ࡣࠊ
ࠕ ᖺ࡟࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀ࣑ࢺࢥࣥࢻࣜ࢔࡜ࡣ␗࡞ࡿș㓟໬⣔ࡢ௦ㅰࢆᢸ࠺Ꮡᅾ࡛
࠶ࡿ࡜ุ᫂ࡋࡓࡇ࡜ࡀ㌿ᶵ࡜࡞ࡾࠊࡑࢀ࠿ࡽಂ↛ὀ┠ࡉࢀࡿࡼ࠺࡟࡞ࡾࡲࡋࡓࠖ࡜ゎㄝࡍࡿࠋࡑࡢᚋࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒Ḟᦆࢆㄪ࡭ࡿࡇ࡜࡛࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢᶵ⬟ࡣᚎࠎ࡟ゎ᫂ࡉࢀ࡚࠸ࡃࡇ࡜
࡟࡞ࡿࠋ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢ௦ㅰᶵ⬟ࡸඛኳᛶ༢⊂㓝⣲Ḟᦆ⑕ࡀሗ࿌ࡉࢀࠊ ᖺ௦ᚋ༙࡟࣌ࣝ࢜࢟ࢯ
ࢩ࣮࣒⑓ࡢᴫᛕࡀ☜❧ࡉࢀ࡚࠸ࡗࡓࠋ
࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢ୺࡞ᙺ๭ࡣ⬡㉁ࡢ௦ㅰ࡛࠶ࡾࠊ≉࡟⬡⫫㓟ࡢș㓟໬ࢆᢸ࠺ࡇ࡜࡛࠶ࡿࠋᴟ㛗㙐⬡⫫㓟࡞࡝ࡢศゎ࡟㛵ࢃࡾࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒࡟㛵㐃ࡋࡓ㓝⣲Ḟᦆ࡟ࡼࡿ⑌ᝈࡀᚎࠎ࡟᫂ࡽ࠿࡟࡞ࡗ࡚ࡣ
࠸ࡓࡶࡢࡢࠊ=HOOZHJHU ⑕ೃ⩌ࡢཎᅉࡣศ࠿ࡽ࡞࠿ࡗࡓࠋ㓝⣲ࡢḞᦆ࡜ࡣูࡢ␗ᖖࡀ⪃࠼ࡽࢀ࡚࠸ࡓࠋ
ࡑ࠺ࡋࡓ୰࡛ࠕ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊ 3(;ࠖࡀ㓝ẕ࡛ぢࡘ࠿ࡾࠊ᪥ᮏู࡛ࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒
ᙧᡂ㑇ఏᏊࡀࣛࢵࢺ࡛ぢࡘ࠿ࡿ࡜࠸࠺◊✲ᡂᯝࡀሗ࿌ࡉࢀ࡚࠸ࡓࠋ
ୗ⃝ඛ⏕ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊ࡜ =HOOZHJHU ⑕ೃ⩌ࢆࡘ࡞ࡄᙜ᫬ࡣぢ࠼࡚࠸࡞࠸㛵㐃ᛶ࡟╔┠ࡋࠊ᪥ᮏ࡛ࣛࢵࢺࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊࢆⓎぢࡋࡓ◊✲ࢢ࣮ࣝࣉ࡜ඹྠ◊✲ࢆ㐍ࡵࡿࡇ࡜࡟
࡞ࡿࠋࡇࡢ୰࡛ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢḞᦆࡋࡓᝈ⪅⣽⬊࡟ࢡ࣮ࣟࢽࣥࢢࡋࡓࣄࢺࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧ
ᡂ㑇ఏᏊࢆᑟධࡍࡿࡇ࡜࡟ࡼࡾࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࢆᅇ᚟ࡉࡏࡿࡇ࡜࡟ᡂຌࡋࡓࠋ
ࡉࡽ࡟ =HOOZHJHU ⑕ೃ⩌ࡢᝈඣ࡜୧ぶࡢ㑇ఏᏊゎᯒࢆ⾜ࡗ࡚ࠊᝈඣࡀ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊ࡟ኚ␗ࢆᣢࡕࠊ୧ぶࡶᑐࡢ㑇ఏᏊࡢ∦᪉࡟ኚ␗ࢆᣢࡘࡇ࡜ࢆ☜ㄆࡋࡓࠋࡇࢀ࡟ࡼࡾ୧ぶ࠿ࡽཷࡅ⥅ࡀࢀࡓ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊࡢ㑇ఏᏊኚ␗࡟ࡼࡗ࡚ᝈඣࡢ =HOOZHJHU ⑕ೃ⩌ࡀᖖᰁⰍయຎໃ㑇ఏᙧᘧ࡛Ⓨ⑕ࡋ࡚࠸ࡿ࡜✺ࡁṆࡵࡓࠋࠕࡇ࠺ࡋ࡚ࠊ=HOOZHJHU ⑕ೃ⩌ࡢ⑓ᅉ㑇ఏᏊࢆୡ⏺࡛ึࡵ࡚ሗ࿌ࡍࡿࡇ࡜࡟࡞ࡾࡲࡋࡓࠋࡑࢀࡲ࡛㑇ఏᛶ⑌ᝈ࡜࠸࠺࡜༢⊂㓝⣲Ḟᦆࡀ▱ࡽࢀ࡚࠸ࡲࡋࡓࡀࠊࡇࡢ⑕ೃ⩌࡛ࡣ㑇ఏᏊኚ␗࡟ࡼࡗ࡚㓝⣲Ḟᦆࡍࡿࡢ࡛ࡣ࡞ࡃࠊ࢜ࣝ࢞ࢿࣛࢆᙧసࡿࡇ࡜ࡀ࡛ࡁ࡞ࡃ࡞ࡿ࡜࠸࠺࣓࢝ࢽࢬ࣒࡛࠶ࡾᮍ▱ࡢࡶࡢ࡛ࡋࡓࠋࡑ
ࡇ࡟ࡣࠊ⑌ᝈࢆᘬࡁ㉳ࡇࡍཎᅉ࡟኱ࡁ࡞㐪࠸ࡀᏑᅾࡋ࡚࠸ࡲࡋࡓࠋ࡞࠾ࠊࡇࡢ⑓ែゎ᫂ࡣ =HOOZHJHU ⑕ೃ⩌ࡢᝈඣࢆ◊✲ࡍࡿᶵ఍࡟ᕠࡾྜࡗࡓ࠿ࡽࡇࡑᡂຌࡋࡓࡶࡢ࡛ࡍࠋ⑌ᝈࡢⓎ⑕࡟㛵ࢃࡿ࣓࢝ࢽࢬ࣒ࡢ
ゎ᫂ࢆྵࡵ࡚ࠊ་⒪ࡢᴫᛕࢆኚ࠼ࠊ᪂ࡋ࠸ᡬࢆ㛤࠸ࡓ◊✲࡜࡞ࡾࡲࡋࡓࠖ࡜ୗ⃝ඛ⏕ࡣ᣺ࡾ㏉ࡿࠋ㹺๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮デ⒪࢞࢖ࢻࣛ࢖ࣥࢆࡲ࡜ࡵࡿ
ୗ⃝ඛ⏕ࢆ୰ᚰ࡜ࡍࡿᒱ㜧኱Ꮫࡢ◊✲ࢢ࣮ࣝࣉࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ␗ᖖ⑕ࡢ⑓ᅉ㑇ఏᏊࢆḟࠎ࡜ゎ᫂ࡋࠊ ᖺ࡟  ␒┠ࡢ㑇ఏᏊࢆ≉ᐃࡋࡓࠋ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ⑓ែࡶᚎࠎ࡟᫂ࡽ࠿࡟࡞ࡾࠊ኱ࡁࡃ  ࡘࡢࢱ࢖ࣉ࡟ศ࠿ࢀࡿࡇ࡜ࡶ᫂☜࡟࡞ࡗࡓࠋ
୍ࡘࡣୗ⃝ඛ⏕ࡀゎ᫂ࡋࡓ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊ࡟㛵ࢃࡿ␗ᖖ࡛ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࢆᙧసࢀ
࡞࠸ࡓࡵ࡟㉳ࡇࡿ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ␗ᖖ⑕࡛࠶ࡿࠋ
ࡶ࠺୍ࡘࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒࡟ྵࡲࢀࡿ㓝⣲ࡸ⭷ࢱࣥࣃࢡࡢ༢⊂Ḟᦆ࡟ࡼࡿ⑌ᝈ࡛࠶ࡿࠋ࣌ࣝ࢜࢟ࢩ
ࢯ࣮࣒⑓࡛᭱ࡶከ࠸๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮㸦$/'㸧࡞࡝ࡀྵࡲࢀࡿࠋ
࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ⑓ែゎ᫂ࡀ㐍ࡳࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊࡢᙺ๭ࡶ඲యീࡀ᫂ࡽ࠿࡟࡞ࡗ
ࡓࡀࠊࠕࡑࢀ࡛ࡶ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ⑓ែ࡟㛵ࡋ࡚ࡣࡲࡔࡲࡔᮍ▱ࡢ㒊ศࡀᑡ࡞ࡃࡣ࠶ࡾࡲࡏࢇࠖ࡜
ୗ⃝ඛ⏕ࡣゎㄝࡍࡿࠋ౛࠼ࡤࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ୺࡞⑓ែ࡜ࡋ࡚⚄⤒ኚᛶࡀ࠶ࡿࡀࠊ⬡㉁ࡢ௦ㅰ࡟␗ᖖࡀ㉳ࡁࡓሙྜ࡟
࡞ࡐ⚄⤒ኚᛶࡀ㉳ࡁࡿࡢ࠿ࡣᮍゎ࡛᫂ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ◊✲ࡣ⌧ᅾ㐍⾜ᙧ࡛ྲྀࡾ⤌ࡲࢀ࡚࠸ࡿࠋ
ࡑ࠺ࡋࡓୗ⃝ඛ⏕ࢆࡣࡌࡵୡ⏺ࡢ◊✲ࢢ࣮ࣝࣉࡢ◊✲ᡂᯝ࡟ࡼࡗ࡚࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢㄆ▱ᗘࡀ╔ᐇ࡟㧗ࡲࡗ࡚ࡁࡓࡢࡶ஦ᐇ࡛࠶ࡿࠋ
ᅜෆ࡛ࡣᣦᐃ㞴⑓࡜ࡋ࡚࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ୍ࡘࠊ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡀ  ᖺ  ᭶࡟ᣦᐃࡉࢀࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓㸦๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࢆ㝖ࡃ㸧ࡀྠᖺ  ᭶࡟ᣦᐃࡉࢀࡿࡇ࡜࡟࡞ࡿࠋ
ୗ⃝ඛ⏕ࡣཌປ⛉◊㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ࡛๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮デ⒪࢞࢖ࢻࣛ࢖ࣥࢆసᡂጤဨ

㛗࡜ࡋ࡚ᦠࢃࡾࠊ ᖺ࡟Ⓨหࠊ⌧ᅾࡶᨵゞ∧ࢆ⦅㞟୰࡛࠶ࡿࠋᾏእ࡟࠾࠸࡚ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ
ᩍ⛉᭩ࢆ  ᖺ  ᭶࡟Ⓨ⾜ࡋࠊᅜෆእࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓デ⒪ࢆᨭ᥼ࡍࡿࠋ
ᒱ㜧኱Ꮫ࡛ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢデ᩿ࢩࢫࢸ࣒ࡢᵓ⠏ࡶ㐍ࡵࡓࠋ඲ᅜࡢ་⒪ᶵ㛵࠿ࡽ࣌ࣝ࢜࢟ࢩࢯ
࣮࣒⑓ࡢ␲࠸ࠊ࠶ࡿ࠸ࡣཎᅉ୙᫂ࡢ⚄⤒ኚᛶ⑌ᝈࡢデ᩿౫㢗ࢆཷࡅ௜ࡅࠊ὾ᯇ་⛉኱Ꮫ࡜ࡶ༠ຊࡋ࡚㑇ఏᏊኚ␗ࢆ≉ᐃࡍࡿ࡞࡝ࡋ࡚ṇ☜࡞デ᩿࡜἞⒪᝟ሗࢆᥦ౪࡛ࡁࡿࡼ࠺࡟ࡋ࡚࠸ࡿࠋࡉࡽ࡟⑌ᝈ᝟ሗࡸᝈ
⪅᳨యࢆ཰㞟ࡋࠊ⑓ែゎ᫂࡜἞⒪ἲࡢ㛤Ⓨࡶ㐍ࡵ࡚࠸ࡿࠋ◊✲ᐊࡢ㧗ᓥⱱ㞝ඛ⏕ࢆ୰ᚰ࡟࣌ࣝ࢜࢟ࢩࢯ
࣮࣒Ḟᦆࢮࣈࣛࣇ࢕ࢵࢩࣗࢆస〇ࠊ⮚ჾࡈ࡜ࡢⓎ⑕ᶵᗎࡢゎ᫂࠿ࡽࠊ⛶㨶ࡢὋࡂࡢ␗ᖖࡸయ⾲ࡀ㏱࡛᫂
࠶ࡿࡇ࡜ࢆ⏕࠿ࡋࡓ๰⸆ࢫࢡ࣮ࣜࢽࣥࢢࡢ㛤Ⓨ◊✲࡟ࡶྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ

㹺᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࢆᐇ⌧ୗ⃝ඛ⏕ࡣ◊✲ࡢᡂᯝࢆ⮫ᗋ࡟⤖ࡧࡘࡅࠊデ⒪యไࡢᩚഛࡲ࡛άືࢆ῝ࡵ࡚࠸ࡿࠋ
୍ࡘࡣ⮬ࡽࡢ◊✲ᐊ࡛デ⒪࡟ࡶᑐᛂྍ⬟࡞⮫ᗋ᳨ᰝయไࢆᩚ࠼ࡓࡇ࡜࡛࠶ࡿࠋ
ୗ⃝ඛ⏕ࡢ◊✲ᐊ࡛ࡣࡶ࡜ࡶ࡜◊✲࡜ࡋ࡚࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ᝈ⪅ࡢ㑇ఏᏊゎᯒ࡞࡝ࢆ⾜ࡗ࡚࠸ࡓࡶ
ࡢࡢࠊ◊✲࡜ࡋ࡚ᑐᛂࡍࡿ㝈ࡾࡣ୺἞་࡟⤖ᯝࢆ㏉ࡍ㝿࡟ࠕ┤᥋ࠊデ᩿ࡢ⏝ࢆ࡞ࡉ࡞࠸ࠖ࡜࠸࠺ὀ㔘ࢆ௜ࡅࡿᚲせࡀ࠶ࡗࡓࠋ
ࠕࡑࢀ࡛ࡣᥦ౪ࡍࡿゎᯒ⤖ᯝ࡟ᑐࡋ࡚୺἞་ࡸᝈ⪅ࡉࢇࡣ୙Ᏻ࡟ᛮ࠺ࠖ࡜ୗ⃝ඛ⏕ࡣ⪃࠼ࠊ᳨ᰝᡭ㡰ࡢ⢭ᗘ⟶⌮ࢆᩚഛࡋࡓୖ࡛ࠊᴟ㛗㙐⬡⫫㓟᳨ᰝ࡟ࡘ࠸࡚ࡣ㞴⑓᳨ᰝ㒊㛛ࢆ㛤タࡋ࡚⑓㝔᳨ᰝ㒊ࡢ⟶⌮ୗ࡛⾜࠺࡜࡜ࡶ࡟ࠊ㑇ఏᏊ᳨ᰝ࡟ࡘ࠸࡚ࡣ⮬ࡽࡢ◊✲Ჷෆ࡟⾨⏕᳨ᰝᡤࢆタ⨨ࡍࡿ⾜ᨻᡭ⥆ࡁࢆ㐍ࡵࡓࠋࡑࡢ⤖ᯝ࡜ࡋ࡚ಖ㝤デ⒪࡟ࡶᑐᛂࡋࡓ⮫ᗋ᳨ᰝࡀྍ⬟࡜࡞ࡾࠊデ᳨᩿ᰝ⤖ᯝࡢಙ㢗ᛶࢆ㧗ࡵࡿࡇ࡜࡟࡞ࡗࡓࠋ

◊✲Ჷෆ࡟⑓㝔᳨ᰝ㒊㞴⑓᳨ᰝᐊࢆタ⨨ࡉࡽ࡟ࠊ᭱ࡶ⑕౛ࡀከ࠸๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡢ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡶᐇ⌧ࡋࡓࠋ ᖺ ᭶࠿ࡽᒱ㜧┴࡛බⓗ࡟⾜ࢃࢀ࡚࠸ࡿ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ࡟๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮࡞࡝ࡢ᳨ᰝࡶ



㏣ຍࡋ࡚ࠊᕼᮃ⪅ࡣ᭷ൾ᳨࡛ᰝࢆཷࡅࡽࢀࡿࡼ࠺࡟࡞ࡗࡓࠋࡑࡢ⤖ᯝࠊ ᭶࡟ࡣ┴ෆฟ⏕ࡢ 㸣㏆ࡃࡢ᪂⏕ඣࡀཷ᳨ࡋ࡚࠸ࡿࠋ
࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ୰࡛ࡶ᭱ࡶከ࠸๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢ⭷ࢱࣥࣃࢡ㉁ࡢ
୍ࡘ $%&' ࡢ㑇ఏᏊ␗ᖖ࡟ࡼࡾⓎ⑕ࡍࡿࡇ࡜ࡀศ࠿ࡗ࡚࠸ࡿࠋࡇࡢ⑌ᝈࡣ ; 㐃㙐ᛶ㑇ఏᙧᘧ࡛࠶ࡾࠊ⏨ᛶ࡟࠾࠸࡚୰ᯡ⚄⤒ࡢⓑ㉁ࡸ⬨㧊ࠊ๪⭈࡟㞀ᐖࢆ㉳ࡇࡍ࡯࠿ࠊዪᛶ࡛ࡶຍ㱋࡜ඹ࡟⬨㧊⑕ࢆ㉳ࡇࡍࡇ࡜ࡀ࠶ࡿࠋ㑇ఏᏊᆺ࡟୍⮴ࡋ࡞࠸」ᩘࡢ⮫ᗋᆺࢆ᭷ࡍࡿࡢࡀ≉ᚩ࡛ࠊከᙬ࡞⑕≧࡛Ⓨ⑕ࡍࡿࡓࡵ࡟⮫ᗋⓗ࡞᪩ᮇデ᩿ࡀ㞴ࡋ࠸ࡇ࡜ࡀၥ㢟࡟࡞ࡿࠋ⮫ᗋ⑓ᆺࡣ኱⬻ᆺ࡜࿧ࡤࢀࡿⓎ㐩㞀ᐖࡸ⾜ື㞀ᐖ࠿ࡽᩘᖺ࡛ᐷࡓࡁࡾ
࡟࡞ࡿ㔜⠜࡞⑓ᆺࡢ࡯࠿ࠊ⬨㧊⑕≧ࢆࡁࡓࡍ๪⭈⬨㧊ࢽ࣮ࣗࣟࣃࢳ࣮ࠊᑠ⬻ኻㄪ࡞࡝ࡀ㉳ࡇࡿᑠ⬻࣭⬻ᖿᆺࠊ๪⭈ᶵ⬟ࡀపୗࡍࡿ࢔ࢪࢯࣥᆺࡀ࠶ࡿࠋ኱⬻ᆺ࡟ᑐࡋ࡚၏୍ࡢ἞⒪ࡀⓎ⑕᪩ᮇࡢ㐀⾑ᖿ⣽⬊⛣᳜࡛࠶ࡾࠊ᪩ᮇデ᩿࡜᪩ᮇ἞⒪ࡀ㔜せ࡟࡞ࡿࠋⓎ⑕๓࠿ࡽᴟ㛗㙐⬡⫫㓟ࡀቑຍࡋ࡚࠸ࡿࡓࡵࠊᐙ⣔ෆゎᯒࡸ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡢᑟධࡀ᪩ᮇデ᩿࡟ࡘ࡞ࡀࡿࠋ
ᒱ㜧኱Ꮫ࡛ࡣ  ᖺ࡟ᐙ⣔ゎᯒ࡟ࡼࡿⓎ⑕๓デ᩿࡟ࡼࡗ࡚᪩ᮇ௓ධࡀྍ⬟࡜࡞ࡾⓎ⑕ࢆ㜵࠸ࡔ஦౛ࡀ࠶ࡾࠊࡇࢀࡀ㌿ᶵ࡟࡞ࡗࡓࠋⓎ⑕๓デ᩿ࡢព⩏ࡀㄆ㆑ࡉࢀ࡚ࠊ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ᥎㐍࡟ࡘ࡞ࡀࡗࡓࠋୗ⃝ඛ⏕ࡣ  ᖺ࠿ࡽ」ᩘࡢᅜࡢࣉࣟࢪ࢙ࢡࢺ◊✲࡟ࡶཧຍࡋ࡚ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ᪂
⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡢ㛤Ⓨࠊయไᩚഛࢆ㐍ࡵࠊ๓㏙ࡢ㏻ࡾ  ᖺ㸲᭶࠿ࡽ᪩ᮇデ᩿࡟ࡘ࡞ࡀࡿ᳨
ᰝࡀጞࡲࡗࡓࠋ
ࡇࡢ᳨ᰝࡣࠊࡲࡎ᪂⏕ඣࡢ⾑ᾮ࠿ࡽᴟ㛗㙐⬡⫫㓟ࢆ᳨ฟࡋࠊ㝧ᛶ౛࡟ࡘ࠸࡚ࡣ⤖ᯝ࡜デ⒪᝟ሗࢆ୺἞
་࡟㏻▱ࡍࡿࠋࡑࡢୖ࡛ಖㆤ⪅࠿ࡽࡢྠពࢆᚓ࡚⢭ᐦデ᩿᪋タ࡟᳨యࢆ㏦ࡾࠊಖ㝤デ⒪᳨࡛ᰝࢆᐇ᪋ࡍ
ࡿࠋࡑࡢ⤖ᯝ࡟ᇶ࡙࠸࡚୺἞་ࡸ඲ᅜࡢ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢᐇ᪋᪋タࡀ㑇ఏ࢝࢘ࣥࢭࣜࣥࢢ࠿ࡽ
ᐙ⣔ෆゎᯒࠊ㛗ᮇணᚋ㏣㊧ࢆ⾜࠺࡜࠸࠺௙⤌ࡳ࡛࠶ࡿࠋࡓࡔ⌧≧࡛ࡣⓎ⑕๓࡟デ᩿ࡋ࡚ࡶ⑓ᆺண ࡣ㞴ࡋࡃࠊࢫࢡ࣮ࣜࢽࣥࢢ᳨ᰝࢆࡼࡾᝈ⪅ࡢ฼┈࡟ࡘ࡞ࡆࡿࡓࡵ࡟ࡣ⑓ᆺࢆつᐃࡍࡿせᅉࡢゎ᫂ࡀୡ⏺୰࡛ᮇᚅࡉࢀ࡚࠸ࡿࠋ
୍᪉ࠊ኱⬻ᆺࢆ᪤࡟Ⓨ⑕ࡋࡓᝈ⪅࡛ࡣ࡛ࡁࡿࡔࡅ᪩ᮇࡢデ᩿ࡀ㔜せ࡛ࠊ
ࠕⓎ⑕᪩ᮇࡣከᙬ࡞⑕≧ࢆ♧ࡍࡓࡵ࡟ᢸᙜ་ࡸᏛᰯࠊ♫఍ࡢၨⓎࡣḞ࠿ࡏࡲࡏࢇࠋ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡢࣃࣥࣇࣞࢵࢺࢆタࡅ࡚ၨⓎ࡟ᙜࡓࡗ࡚࠸ࡲࡍࠋᗂඣᮇ࠿ࡽᛮ᫓ᮇࡲ࡛ࡢ㛫࡟ึᮇ⑕≧ࡸేⓎ⑕≧࡜ࡋ࡚ከ࠸ࡶࡢࡣࠊぢ࡙ࡽࡑ࠺࡟ࡋ࡚࠸ࡿࡶࡢࡢどຊ᳨ᰝ࡛␗ᖖࡀ࡞࠸ࠊᩳどࡀẼ࡟࡞ࡿࠊ▱ⓗ㞀ᐖࡸ⮬㛢⑕ࠊⴠࡕ╔ࡁࡢ࡞ࡉࠊᏛ
⩦ᅔ㞴࡞࡝࡟ὀពࡀᚲせ࡛ࡍࠋデ᩿ࡢయไࢆ☜❧ࡍࡿࡇ࡜ࡶ㔜せ࡟࡞ࡾࡲࡍࠋデ᩿ᚋࡣࠊ࡛ࡁࡿࡔࡅ㎿㏿࡟㦵㧊ࣂࣥࢡࡸ⮖ᖏ⾑ࣂࣥࢡ࠿ࡽ +/$ ࡢᆺࡀ୍⮴ࡋࡓ㐀⾑ᖿ⣽⬊⛣᳜࡟ࡘ࡞ࡆࡿࡇ࡜ࡀ㔜せ࡟࡞ࡾࡲࡍࠖ࡜ୗ⃝ඛ⏕ࡣヰࡍࠋୗ⃝ඛ⏕ࡣࡇࢀ࠿ࡽࡶ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ◊✲ᡂᯝࢆ⮫ᗋ࡟ࡘ࡞ࡆࠊ ே࡛ࡶከࡃࡢ㞴⑓ᝈ⪅ࡢணᚋᨵၿࢆ┠ᣦࡍάືࢆ⥅⥆ࡍࡿࠋୗ⃝ඛ⏕ࡢ⟶⌮ࡍࡿ㑇ఏᏊ᳨ᰝᐊࡀⓏ㘓⾨⏕᳨ᰝᡤ࡛࠶ࡿࡇ࡜ࢆᥖ♧ࡋ࡚࠸ࡿୗ⃝ఙ⾜㸦ࡋࡶࡊࢃ࣭ࡢࡪࡺࡁ㸧ඛ⏕ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ࢤࣀ࣒◊✲ศ㔝ᩍᤵ ᖺࠊᒱ㜧኱Ꮫ་Ꮫ㒊ࢆ༞ᴗࠋ㫽ྲྀ኱Ꮫࠊᒱ㜧┴❧ᒱ㜧⑓㝔࡞࡝ࢆ⤒࡚ࠊ ᖺᒱ㜧኱Ꮫᑠඣ⛉ㅮᖌࠊ ᖺࢺࣟࣥࢺᑠඣ⑓㝔ࠊ ᖺᒱ㜧኱Ꮫᑠඣ⛉ຓᩍᤵࠊ ᖺ࡟ྠ኱Ꮫ⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ᩍᤵࠊ࠾ࡼࡧᑠඣ⛉ే௵ᩍᤵࠋ ᖺࡼࡾྠ኱Ꮫ኱Ꮫ㝔㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉་⒪᝟ሗᏛᑓᨷᩍᤵࠋ ᖺࡼࡾྠ኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ࢤࣀ࣒◊✲ศ㔝ᩍᤵࠋ ᖺࡼࡾྠ኱Ꮫ⢾㙐⏕࿨ࢥ࢔◊✲ᡤ⢾㙐ศᏊ⛉Ꮫ◊✲ࢭࣥࢱ࣮ᩍᤵࠋ
࣒ࢥከ⢾ࣉࣟࢧ࢖ࢺྲྀᮦ࣏࣮ࣞࢺ 

᎘Ẽᛶ⳦◊✲ศ㔝
Division of Anaerobe Researchࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : kenki@gifu-u.ac.jp
TEL : 058-230-6554, 6555
FAX : 058-230-6551

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࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫ ی‬᎘Ẽᛶ⳦◊✲ศ㔝
1. ἢ㠉

ḟ

2. ⫋ဨᵓᡂ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

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3. ◊✲࡜άືࡢ᪉㔪ࠕ ࡘࡢᰕࠖ4. ศ㔝᪋タ࡜୺࡞タഛ

5. ᎘Ẽᛶ⳦ಖᏑ⳦ᰴࡢಖ᭷≧ἣ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭



6. ศ㔝ࡢᴗົ࡜ᨭ᥼
7. ᨭ᥼ࡢᐇ⦼

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8. ᩍဨࡢ◊✲㺃ᩍ⫱㺃♫఍άື࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫ ی‬᎘Ẽᛶ⳦◊✲ศ㔝᎘Ẽᛶ⳦◊✲ศ㔝ࡣ୺࡟ࣄࢺ࣭ື≀࡟⏤᮶ࡍࡿ೫ᛶ᎘Ẽᛶ⳦㸦㓟⣲Ꮡᅾࡀ⏕Ꮡ࡟୙฼࡟ാࡃ⣽⳦㸧ࢆᖜᗈࡃᢅࡗ࡚࠸ࡿᅜෆ࡛၏୍ࡢ◊✲᪋タ࡛࠶ࡿࠋጞࡲࡾࡣࠊᡃࡀᅜ࡟࠾ࡅࡿ⮫ᗋ᎘Ẽᛶ⳦◊✲ࡢࣃ࢖࢜ࢽ࢔࡛࠶ࡿᨾ㕥ᮌ㷋୍㑻ࠊᨾୖ㔝୍᝴ࡢ୧ᒱ㜧኱Ꮫྡ㄃ᩍᤵࡢᴗ⦼࡟ᑐࡋ࡚ 1978 ᖺ㸦᫛࿴ 53 ᖺ㸧࡟タ⨨ࡉࢀࡓ་Ꮫ㒊㝃ᒓ᎘Ẽᛶ⳦ᐇ㦂᪋タ࡛࠶ࡿࠋ௨᮶ࠊᒱ㜧኱Ꮫࡢ≉Ⰽ࠶ࡿ᪋タ࡜ࡋ࡚ࠊᡃࡀᅜ࡟࠾ࡅࡿ
⮫ᗋ᎘Ẽᛶ⳦ᏛࡢⓎᒎ࡟ᐤ୚ࡋ࡚ࡁࡓࠋ⌧ᅾ࡛ࡣࠊ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࡢ㸯ศ㔝࡜ࡋ࡚ࠊ⮫ᗋ⣽⳦ࡢࡳ࡟࠿࠿ࢃࡽࡎࠊ᎘Ẽⓗ⎔ቃ࡛ࡢᐇ㦂࡟ࡘ࠸࡚ࡢࢥࣥࢧࣝࢸ࣮ࢩࣙࣥࠊᶵჾࡢ౪୚ࠊ೫ᛶ᎘Ẽᛶ⳦ࡢศㆡ➼ࡢᨭ᥼ࢆ⾜ࡗ࡚࠸ࡿࠋ᪋タࡢᡂࡾ❧ࡕ࡜ᛶ㉁ୖࠊ௚ศ㔝࡜␗࡞ࡾࠊᏛෆඹྠ฼⏝᪋タ࡛ࡣ↓ࡃࠊឤᰁ⑕㡿ᇦ࡜ࣛ࢖ࣇࢧ࢖࢚ࣥࢫ◊✲࡟㛵ࢃࡿ᎘Ẽᛶ⳦ࡢࣞࣇ࢓ࣞࣥࢫࢭࣥࢱ࣮ᶵ⬟ࢆᣢࡘ᪋タ࡜ࡋ࡚ࠊ඲
ᅜⓗ࡞ᨭ᥼ࢆ⾜ࡗ࡚࠸ࡿࠋ

᎘Ẽᛶ⳦ศ㞳ቑ⳦⏝ᇵᆅ
GAMᇵᆅ䠄Gifu Anaerobic Medium䠅 䛸)XVREDFWHULXPᒓ䛾㚷ูᇵ㣴䛾䛯䜑䛾ᒱ኱ᘧ᎘Ẽᇵ㣴䝆䝱䞊䠄㯪᫂ᮇ䛻㛤Ⓨ䛥䜜䛯᎘Ẽ䝆䝱䞊1960ࠥ70㡭䠛䠅ኚἲFMᇵᆅ

1. ἢ㠉
᫛࿴53ᖺ10᭶་Ꮫ㒊㝃ᒓ᎘Ẽᛶ⳦ᐇ㦂᪋タ㛤タࡉࢀࡿ᪋タ㛗㕥ᮌ⚈୍㑻㸦ే௵㸧ࠊᑓ௵ᩍᤵ ୖ㔝୍᝴

᫛࿴54ᖺ4᭶᪋タ㛗ୖ㔝୍᝴ ╔௵

ᖹᡂ5ᖺ 3᭶᪋タ㛗ୖ㔝୍᝴ ㏥௵

ᖹᡂ5ᖺ 4᭶᪋タ㛗Ώ㑓㑥཭ ╔௵

ᖹᡂ15ᖺ4᭶ᨵ⤌࡟ࡼࡾ⏕࿨⛉Ꮫ⥲ྜᐇ㦂ࢭࣥࢱ࣮᎘Ẽᛶ⳦ᐇ㦂ศ㔝ศ㔝㛗 Ώ㑓㑥཭

ᖹᡂ17ᖺ4᭶ᨵ⛠࡟ࡼࡾ⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮᎘Ẽᛶ⳦◊✲ศ㔝ศ㔝㛗 Ώ㑓㑥཭㸦ᖹᡂ25ᖺ3᭶ࡲ࡛㸧⏣୰㤶࠾㔛㸦ᖹᡂ25ᖺ4᭶㹼㸧ᖹᡂ30ᖺ4᭶ᨵ⤌࣭ᨵ⛠࡟ࡼࡾ◊✲᥎㐍㺃♫఍㐃ᦠᶵᵓ ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮᎘Ẽᛶ⳦◊✲ศ㔝ศ㔝㛗 ⏣୰㤶࠾㔛

௧࿴2ᖺ4᭶

ᨵ⤌࣭ᨵ⛠࡟ࡼࡾ㧗➼◊✲㝔 ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮᎘Ẽᛶ⳦◊✲ศ㔝ศ㔝㛗 ⏣୰㤶࠾㔛

2. ⫋ဨᵓᡂ

ᩍᤵ㸸⏣୰㤶࠾㔛ᢏ⾡⿵బဨ㸸୰ᕝᮁᏊ

3. ◊✲࡜άືࡢ᪉㔪ຓᩍ㸸ᚋ⸨㝯ḟᯘᑗ኱ᇼ஭⨾⣖

ࠕ4ࡘࡢᰕࠖ

1㸧᎘Ẽᛶ⳦ឤᰁ⑕࡟ࡘ࠸࡚ࡢᇶ♏ⓗ⮫ᗋ⣽⳦Ꮫⓗ࡞◊✲ࢆ⾜࠺ࠋࡇࡢ◊✲ᡂᯝ࡟ࡼࡾࠊࡇࢀࡲ࡛ࡶ⮫ᗋ᎘Ẽᛶ⳦ᏛࡢⓎᒎ࡟㈉⊩ࡋ࡚ࡁࡓࠋศ㞳㺃ᇵ㣴㺃ྠᐃࢶ࣮ࣝࡢ
Ⓨᒎ࡟ࡼࡾࠊ⮫ᗋ᎘Ẽᛶ⳦ࡢ␿Ꮫࡶ㐣Ώᮇ࡟࠶ࡾࠊࡲࡓࠊᚤ⏕≀ࡣࠊ♫఍᝟ໃࠊ⏕ά⩦័➼࡛ࡶࡓࡽࡉࢀࡿ⎔ቃኚ໬࡟ࡼࡾኚ໬ࡋ࠺ࡿࡓࡵࠊ᝟ሗࡢUp Dateࡀᚲせ࡛࠶ࡿࠋ␿Ꮫ᝟ሗࡢ඘ᐇࡀࠊṇࡋ࠸デ᩿ἲ࡟ᇶ࡙ࡃ㐺ษ࡞἞⒪ἲࡢ㑅ᢥࢆྍ⬟࡟ࡋࠊ἞⒪ἲࡢᨵⰋࡸ᪂ࡋ࠸἞⒪ἲࡢ㛤Ⓨ࡟⧅ࡀࡿ࡜࡜ࡶ࡟ࠊ
ண㜵་Ꮫ࡟ࡶ⧅ࡀࡿࠋ

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2㸧◊✲ᡂᯝࡢᛂ⏝ࠊ᎘Ẽᛶ⳦ឤᰁ⑕ࡢデ᩿ἲࡢᇶ‽໬ࡸ࣐ࢽࣗ࢔ࣝ໬ࠊࡑࡋ࡚ࡑࡢᩍ⫱ᬑཬࢆ⾜࠺ࠋᙜ᪋タ࡛ẖᖺ㸯ᅇ1㐌㛫ࡢ᪥⛬࡛⾜࠺᎘Ẽᛶ⳦᳨ᰝᢏ⾡ኟᮇࢭ࣑ࢼ࣮ࡣࠊࡍ࡛࡟40ᖺ௨ୖࡢṔྐࡀ࠶ࡾࠊ᎘Ẽᛶ⳦ឤᰁ⑕デ᩿ࡢࡓࡵࡢᢏ⾡ᣦᑟ࡜᝟ሗᥦ౪ࡢሙ࡛࠶ࡾ⥆ࡅ࡚࠸ࡿࠋࡉࡽ࡟ࠊཷㅮ⪅࡟ᑐࡍࡿㅮ⩦఍⤊஢ᚋࡢᨭ᥼άືࡣࠊ㟁ヰࡸe-mail࡛ࡢࢥࣥࢧࣝࢸ࣮ࢩࣙࣥࠊ᳨య࠿ࡽࡢ⑓ཎ⳦ࡢ⣽⳦Ꮫⓗ᳨ᰝࢧ࣏࣮ࢺࡢᙧ࡛ᐇ᪋ࡋ࡚࠸ࡿࠋࡲࡓࠊ◊✲ᡂᯝࢆᑟධࡋࡓࠊ⳦ឤᰁ⑕ࡢデ᩿ἲࡢᶆ‽໬ࠊ࣐ࢽࣗ࢔ࣝ໬࡟ດࡵࡿࠋ

3㸧⮫ᗋ⌧ሙ࠿ࡽࡢ᎘Ẽᛶ⑓ཎ⳦ࡢ཰㞟࡜ಖᏑ࠾ࡼࡧࡑࡢศ୚ࢆ⾜࠺ࠋࡑࡢᛶ㉁ୖࠊᝈ⪅࠿ࡽࡢ᎘Ẽᛶ⑓ཎ⳦ࡢ཰㞟ࡣ㏻ᛶ⳦࡟ẚ࡭࡚ࠊᴟࡵ࡚㞴ࡋ࠸௙஦࡛࠶ࡿࠋᙜศ㔝࡛ࡣࠊ᎘Ẽᛶ⳦ࡢཧ⪃⳦ᰴࡸ඲ᅜྛᆅࡢ⑓㝔࠿ࡽࡢデ᩿ᨭ᥼౫㢗ࢆ㏻ࡋ࡚ศ㞳ࠊྠᐃࡋࡓ⳦ᰴࢆಖᏑ
ࡋ࡚࠸ࡿࠋ⌧ᅾࡢ࡜ࡇࢁࠊಖᏑᰴᩘࡣ7,000ᰴ௨ୖ࡛ࠊከᵝ࡞⮫ᗋศ㞳ࡢ೫ᛶ᎘Ẽᛶ⳦ࢆྵࡴࢥࣞࢡࢩࣙࣥ࡜
ࡋ࡚ࠊᅜෆ࡟㢮ࢆぢ࡞࠸ࠋࡇࢀࡽࡢ⳦ᰴ࡟ࡘ࠸࡚ࡣᙜ᪋タࡢ㔜せ࡞◊✲ᮦᩱ࡜ࡋ࡚⏝࠸ࡽࢀ࡚࠸ࡿ௚ࠊ
ᅜෆእࡢ኱Ꮫࠊ◊✲ᡤ࡞࡝◊✲ᩍ⫱᪋タࡸࠊ〇⸆࠶ࡿ࠸ࡣヨ⸆ࡢ㛤Ⓨ࡟㛵ಀࡋ࡚࠸ࡿẸ㛫ࡢ◊✲ᡤ࡟ศ୚ࡉࢀ࡚࠾ࡾࠊ◊✲ࠊᩍ⫱ࠊ⏘ᴗ⫱ᡂ࡟᭷ຠ฼⏝ࡉࢀ࡚࠸ࡿࠋ

4㸧་⒪㛵ಀ⪅࡟ᑐࡍࡿ᎘Ẽᛶ⳦࡜᎘Ẽᛶ⳦ឤᰁ⑕࡟㛵ࡍࡿၨⵚάືࢆ✚ᴟⓗ࡟⾜࠺ࠋ௒᪥ࡢ኱Ꮫ་Ꮫ㒊࡟࠾ࡅࡿឤᰁ⑕Ꮫࡢㅮ⩏ࡀෆ⛉Ꮫࡢㅮ⩏඲య࡟༨ࡵࡿ๭ྜࡣࠊᴟࡵ࡚ᑡ࡞࠸ࡇ࡜
ࡀࢃ࠿ࡗ࡚࠸ࡿࠋឤᰁ⑕Ꮫࡢ୰࡛ࡶࠊ᎘Ẽᛶ⣽⳦Ꮫ࡟㛵ࡍࡿㅮ⩏ࡢ༨ࡵࡿ๭ྜࡣࡉࡽ࡟ᴟࡵ࡚ᑡ࡞ࡃࠊ
ࡑࡢᩍ⫱ࡢ࡯࡜ࢇ࡝ࡣࠊ༞ᚋᩍ⫱࡟౫Ꮡࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸⌧≧࡛࠶ࡿࠋ᎘Ẽᛶ⣽⳦Ꮫ࡜᎘Ẽᛶ⳦ឤᰁ⑕ࡢ⋡ᚋᩍ⫱ࡢࡓࡵࡢࠊᮏ᪋タࡢᙺ๭ࡣࢃࡀᅜ࡟࠾࠸࡚ᴟࡵ࡚኱ࡁࡃࠊᖖ࡟᪂ࡋ࠸᝟ሗࡢ཰㞟࡟ດࡵࠊồࡵ࡟ᛂࡌ࡚ᑐᛂ࡛ࡁࡿែໃࢆᩚ࠼࡚࠸ࡿࠋ



4. ศ㔝᪋タ࡜୺࡞タഛ᎘Ẽᛶ⳦◊✲ศ㔝ࡣࠊ་Ꮫ㒊Ჷ㸵㝵࡟఩⨨ࡍࡿࠋP2 ࣞ࣋ࣝࡢᚤ⏕≀ᐇ㦂ᐊ࡜⣔⤫ಖᏑᐊࢆഛ࠼࡚࠸ࡿࠋ

I. ᎘Ẽᛶࢢ࣮ࣟࣈ࣎ࢵࢡࢫ㸦1 ྎ㸧ࠊ᎘Ẽᛶ࣮࣡ࢡࢫࢸ࣮ࢩࣙࣥ㸦1 ྎ㸧㓟⣲ࢆྵࡲ࡞࠸ΰྜ࢞ࢫ⎔ቃ㸦❅⣲ 82㸣⛬ᗘࠊⅣ㓟࢞ࢫ 8㸣⛬ᗘࠊỈ⣲ 10㸣⛬ᗘ㸧ୗ࡛ࡢసᴗࠊ
ᇵ㣴ࡀྍ⬟ࢸ࣮ࣁ࣮ᘧ࢔ࢼ࢚ࣟ࣎ࢵࢡࢫ ANX-1W ࠙ᖹἑ〇సᡤࠚ௚ 1ྎ

II. ࢞ࢫ⨨᥮⿦⨨(1 ྎ)㧗ᗘ࡞᎘Ẽ≧ែࢆᚲせ࡜ࡍࡿᇵᆅ➼ࡢㄪᩚ࡟౑⏝ࡍࡿჾᶵ࢞ࢫ⨨᥮⿦⨨(GR-8 ᆺ)࠙୕⤀ᕤᴗࠚ



III. ᚤ⏕≀ྠᐃࢩࢫࢸ࣒(MALDI TOF MS)

MALDI TOF MS ࡟ࡼࡿ⣽⳦࣭┿⳦ࡢྠᐃ⿦⨨ࢹ࣮ࢱ࣮࣋ࢫࡀ࠶ࢀࡤࠊ
㎿㏿࡛㧗⢭ᗘ࡞ྠᐃࡀྍ⬟VITEK MS Plus ࠙ࣅ࣓࣮࢜ࣜࣗࠚ

VI. ⳦ᰴಖᏑ⏝㉸ప ࣇ࣮ࣜࢨ࣮(3 ྎ)5. ᎘Ẽᛶ⳦ಖᏑ⳦ᰴࡢಖ᭷≧ἣa) ᎘Ẽᛶ⳦ࣞࣇ࢓ࣞࣥࢫ⳦ᰴ

⣙290ᰴ

ಖ᭷⳦ᰴᴫせ㸦ᒓ㸧࢔ࢡࢳࣀࣂࢡࢸࣜ࢔㛛I.

Actinobacteria࢔ࢡࢳࣀ࣐࢖ࢭࢫᒓ Actinomycesࣔࣅࣝࣥ࢝ࢫᒓ

Mobiluncus࢟ࣗࢸ࢕ࣂࢡࢸ࣒ࣜ࢘ᒓ Cutibacterium
II. ࣅࣇ࢕ࢻࣂࢡࢸ࣒ࣜ࢘ᒓ Bifidobacterium
III. ࢔ࢺ࣏ࣅ࣒࢘ᒓ

Atopobiumࢥࣜࣥࢭࣛᒓ Collinsella࢜ࣝࢭࢿࣛᒓ Olsenella
IV. ࢚࣮࢞ࢭࣛᒓ Eggerthellaࢫࣛࢵ࢟࢔ᒓ Slackiaࣇ࢓࣮࣑࣮࢟ࣗࢸࢫ㛛

Firmicutesࢡࣟࢫࢺࣜࢪ࣒࢘ᒓ Clostridium࣌ࣉࢺࢫࢺࣞࣉࢺࢥࢵ࢝ࢫᒓ Peptostreptococcusࣇ࢕ࢿࢦࣝࢹ࢕࢔ᒓ Finegoldiaࣃࣝࣅࣔࢼࢫᒓ Parvimonas࣌ࣉࢺࢽࣇ࢕ࣝࢫᒓ Peptoniphilus࢔ࢿࣟࢥࢵ࢝ࢫᒓ Anaercoccusࣇ࢕ࣜࣇ࢓ࢡࢱ࣮ᒓ Filifactor࣮ࣘࣂࢡࢸ࣒ࣜ࢘ᒓ Eubacteriumࣔࢠࣂࢡࢸ࣒ࣜ࢘ᒓ Mogibacteriumࢩ࣮ࣗࢻ࣑ࣛࢽࣂࢡࢱ࣮ᒓ Pseudoramibacterࢩ࣮ࣗࢻࣇࣛ࣎ࢽࣇࣛࢡࢱᒓ Pseudoflavonifracterࢹ࢕࢔ࣜࢫࢱ࣮ᒓ Dialister࣋࢖ࣚࢿࣛᒓ Veillonellaࣈࣞ࢖ࢹ࢕࢔ᒓ Bulleidiaࢯࣟࣂࢡࢸ࣒ࣜ࢘ᒓ Solobacteriumࢫࢱࣇ࢕ࣟࢥࢵ࢝ࢫᒓ Staphylococcusࢤ࣓ࣛᒓ Gemellaࣛࢡࢺࣂࢳࣛࢫᒓ Lactobacillusࣉࣟࢸ࢜ࣂࢡࢸࣜ࢔㛛Proteobacteriașࣉࣟࢸ࢜ࣂࢡࢸࣜ࢔⥘ Betaproteobacteriaࢧࢵࢸࣞࣛᒓ Sutterellațࣉࣟࢸ࢜ࣂࢡࢸࣜ࢔⥘Deltaproteobacteriaࢹࢫࣝࣇ࢛ࣅࣈࣜ࢜ᒓ Desulfovibrioࣂ࢖࢜ࣇ࢕ࣛᒓ BilophilaȜࣉࣟࢸ࢜ࣂࢡࢸࣜ࢔⥘ Epsilonproteobacteria࢝ࣥࣆࣟࣂࢡࢱ࣮ᒓ Campylobacterࣂࢡࢸࣟ࢖ࢹࢫ㛛

Bacteroidetesࣂࢡࢸࣟ࢖ࢹࢫᒓ Bacteroides࣏ࣝࣇ࢕ࣟࣔࢼࢫᒓ Porphyromonasࣉࣞ࣎ࢵࢸࣛᒓ Prevotella࢝ࣉࣀࢧ࢖ࢺࣇ࢓࣮࢞ᒓ Capnocytophagaࣇࢰࣂࢡࢸࣜ࢔㛛 Fusobacteriaࣇࢰࣂࢡࢸ࣒ࣜ࢘ᒓ Fusobacteriumࣞࣉࢺࢺࣜ࢟࢔ᒓ Leptotrichiab) ྛ✀ឤᰁ⑕ࠊ⑓ែ⏤᮶ࡢ᎘Ẽᛶ⳦⮫ᗋศ㞳ᰴ

⣙9,000ᰴ⳦ᰴ⏤᮶ᴫせ⫹㐨ឤᰁ⑕ ࠊ⭡⭍ෆឤᰁ⑕ࠊ⭠⟶ឤᰁ⑕ࠊ⬻⮋⒆ࠊ⳦⾑⑕ࠊ⓶⭵㌾㒊⤌⧊ឤᰁ⑕ࠊࡑࡢ௚ࡢ
⏘፬ே⛉ឤᰁ⑕ࠊ⪥㰯ဗႃ⛉ឤᰁ⑕ࠊཱྀ⭍እ⛉㡿ᇦឤᰁ⑕ࠊ࿧྾ჾ⛉㡿ᇦឤᰁ⑕ࠊᩚᙧእ⛉ឤᰁ⑕ࠊ౽ࠊ㰯⭍ࢧࣥࣉࣝࠊ㝔ෆ⎔ቃಖ᭷⳦ᰴᴫせ㸦ᒓ㸧࢔ࢡࢳࣀࣂࢡࢸࣜ࢔㛛I.

Actinobacteria࢔ࢡࢳࣀ࣐࢖ࢭࢫᒓ

Actinomycesࣔࣅࣝࣥ࢝ࢫᒓ Mobiluncus࢟ࣗࢸ࢕ࣂࢡࢸ࣒ࣜ࢘ᒓ CutibacteriumII.

ࣅࣇ࢕ࢻࣂࢡࢸ࣒ࣜ࢘ᒓ Bifidobacterium࣮࢞ࢻࢿࣞࣛᒓ Gardnerellaࣃࣛࢫ࢝ࣝࢻࣅ࢔ᒓ

Parascardoviaࢫ࢝ࣝࢻࣅ࢔ᒓ Scardovia



III.

IV.

࢔ࢺ࣏ࣅ࣒࢘ᒓ AtopobiumࢥࣜࣥࢭࣛᒓCollinsella࢜ࣝࢭࢿࣛᒓ

Olsenella࢚࣮࢞ࢭࣛᒓ

Eggerthellaࢫࣛࢵ࢟࢔ᒓ

Slackiaࣇ࢓࣮࣑࣮࢟ࣗࢸࢫ㛛

Firmicutesࢡࣟࢫࢺࣜࢪ࣒࢘ᒓ Clostridium࣌ࣉࢺࢫࢺࣞࣉࢺࢥࢵ࢝ࢫᒓ Peptostreptococcusࣇ࢕ࢿࢦࣝࢹ࢕࢔ᒓ Finegoldiaࣃࣝࣅࣔࢼࢫᒓ Parvimonas࣌ࣉࢺࢽࣇ࢕ࣝࢫᒓ Peptoniphilus࢔ࢿࣟࢥࢵ࢝ࢫᒓ Anaercoccusࣇ࢕ࣜࣇ࢓ࢡࢱ࣮ᒓ Filifactor࣮ࣘࣂࢡࢸ࣒ࣜ࢘ᒓ Eubacteriumࣔࢠࣂࢡࢸ࣒ࣜ࢘ᒓ Mogibacteriumࢩ࣮ࣗࢻ࣑ࣛࢽࣂࢡࢱ࣮ᒓ

Pseudoramibacterࢩ࣮ࣗࢻࣇࣛ࣎ࢽࣇࣛࢡࢱᒓ Pseudoflavonifracterࢹ࢕࢔ࣜࢫࢱ࣮ᒓ Dialister࣋࢖ࣚࢿࣛᒓ Veillonellaࣈࣞ࢖ࢹ࢕࢔ᒓ Bulleidiaࣈࣛ࢘ࢸ࢕࢔ᒓ Blautiaࢯࣟࣂࢡࢸ࣒ࣜ࢘ᒓ Solobacteriumࢫࢱࣇ࢕ࣟࢥࢵ࢝ࢫᒓ Staphylococcusࢤ࣓ࣛᒓ Gemellaࣛࢡࢺࣂࢳࣛࢫᒓ Lactobacillusࣉࣟࢸ࢜ࣂࢡࢸࣜ࢔㛛Proteobacteriașࣉࣟࢸ࢜ࣂࢡࢸࣜ࢔⥘Betaproteobacteriaࢧࢵࢸࣞࣛᒓ Sutterella࢚࢖ࢣࢿࣛᒓ Eikenellațࣉࣟࢸ࢜ࣂࢡࢸࣜ࢔⥘Deltaproteobacteriaࢹࢫࣝࣇ࢛ࣅࣈࣜ࢜ᒓ Desulfovibrioࣂ࢖ࣟࣇ࢕ࣛᒓ BilophilaȜࣉࣟࢸ࢜ࣂࢡࢸࣜ࢔⥘Epsilonproteobacteria࢝ࣥࣆࣟࣂࢡࢱ࣮ᒓ Campylobacterࣂࢡࢸࣟ࢖ࢹࢫ㛛

Bacteroidetesࣂࢡࢸࣟ࢖ࢹࢫᒓ Bacteroides࣏ࣝࣇ࢕ࣟࣔࢼࢫᒓ Porphyromonasࣉࣞ࣎ࢵࢸࣛᒓ Prevotella࢝ࣉࣀࢧ࢖ࢺࣇ࢓࣮࢞ᒓ Capnocytophagaࣇࢰࣂࢡࢸࣜ࢔㛛 Fusobacteriaࣇࢰࣂࢡࢸ࣒ࣜ࢘ᒓ Fusobacteriumࣞࣉࢺࢺࣜ࢟࢔ᒓ Leptotrichiaࢫࣆࣟࢣ࣮ࢱ㛛 Spirochaetesࣈࣛ࢟ࢫࣆࣛᒓ Brachyspiraࢩࢿࣝࢠࢫࢸࢫ㛛 Synergistetesࢩࢿࣝࢠࢫࢸࢫᒓ Synergistes

ᖺᗘูෆヂ
ᖺ

GAI No.

཰㞟ᰴᩘ1991ࠥ2008(# 91000㹼08503)

7119

2009

(# 09001㹼09209)

209

2010

(# 10001㹼10202)

202

2011

(# 11001㹼11207)

207

2012

(# 12001㹼12149)

149

2013

(# 13001㹼13107)

107

2014

(# 14001㹼14227)

227

2015

(# 15001㹼15240)

240

2016

(# 16001㹼16135)

135

2017

(# 17001㹼17313)

313

2018

(# 18001㹼18160)

160

2019

(# 19001㹼19029)

29

2020

(# 20001㹼20216)

216

2021

(# 21001㹼21144)

144



6. ศ㔝ࡢᴗົ࡜ᨭ᥼

1) ⳦ᰴ⥔ᣢ࣭⣔⤫ಖᏑ2) ᎘Ẽᛶ⳦ࡢ⏕ែ࡞࡝࡟㛵ࡍࡿၥ࠸ྜࢃࡏ࡬ࡢᑐᛂ3) ᇵ㣴ἲ࡞࡝◊✲ୖࡢᢏ⾡ⓗ࡞┦ㄯ࡬ࡢᑐᛂ4) ᎘Ẽ⎔ቃࢆᚲせ࡜ࡍࡿ◊✲ࡢᨭ᥼5) ᎘Ẽᛶ⳦ࢆ୰ᚰ࡜ࡋࡓ⣽⳦ྠᐃࠊឤཷᛶ ᐃ6) ᎘Ẽᛶ⳦ࡢᅜෆእࡢ◊✲⪅࡟ᑐࡍࡿศㆡ
㸦⟶⌮యไ࣭タഛࡀᩚࡗ࡚࠸ࡿ◊✲ᐊᑐ㇟㸧᪥ᮏ⣽⳦Ꮫ఍ᩍ⫱⏝⳦ᰴࡢศ୚
᪥ᮏ໬Ꮫ⒪ἲᏛ఍MIC ᐃጤဨ఍ᣦᐃࢥࣥࢺ࣮ࣟࣝ⳦ᰴࡢศ୚
ྛ✀ྠᐃ⏝࢟ࢵࢺࡢ⢭ᗘ⟶⌮⏝⳦ᰴࡢศ୚
ᢠ⳦⸆ࠊヨ⸆㛤Ⓨࡢࡓࡵࡢ⳦ᰴࡢศ୚
7) ⮫ᗋ᎘Ẽᛶ⳦࡟ࡘ࠸࡚ࡢㅮ⩦఍㛤ദ᎘Ẽᛶ⳦᳨ᰝᢏ⾡ࢭ࣑ࢼ࣮

7. ᨭ᥼ࡢᐇ⦼

㸦1㸧┦ㄯ࣭ၥྜࡏ᳨࣭ᰝ౫㢗௧࿴ 3 ᖺᗘ
࣭⮫ᗋᮦᩱ࠿ࡽศ㞳ࡉࢀࡓ᎘Ẽᛶ⳦ࡢヲ⣽ྠᐃ࡜⸆๣ឤཷᛶヨ㦂㸸 1௳2ᰴ(┴እ་⒪ᶵ㛵)࣭⮫ᗋᮦᩱ࠿ࡽศ㞳ࡉࢀࡓ᎘Ẽᛶ⳦ࡢヲ⣽ྠᐃ㸸⾑ᾮᇵ㣴ศ㞳⳦ 1௳㸦┴ෆ་⒪ᶵ㛵㸧࣭┦ㄯ࠙◊✲ᡭἲࠊᇵ㣴ࠊྠᐃࠊឤཷᛶ ᐃἲ࡞࡝ᐇ㦂ୖࡢᢏ⾡ⓗ࡞┦ㄯ࡬ࡢᑐᛂࠚ㸸Ꮫෆ 1 ௳ࠊ┴እ኱Ꮫ㸦་⒪⣔㸧1 ௳ࠊ┴እ኱Ꮫ 1 ௳࣭ၥ࠸ྜࢃࡏ ࠙⑓ཎ⳦ࡢ⏕ែ࡟ࡘ࠸࡚ࠚ┴እ኱Ꮫ

1 ௳ࠊ┴እ⮬἞య 2 ௳࠙᎘Ẽᛶ⳦ࡢྠᐃ࡟ࡘ࠸࡚ࠚ┴እ኱Ꮫ 1 ௳࠙⳦✀ྡ࡟ࡘ࠸࡚ࠚ┴እ௻ᴗ 1 ௳࣭⳦ᰴࡢ⥔ᣢ Ꮫෆ 1 ௳࣭ᢏ⾡ᥦ౪ 2 ௳ ┴ෆ௻ᴗ

㸦2㸧᪂つಖᏑᩘ 114 ᰴ
㸦3㸧⳦ᰴศㆡ ྛ✀᎘Ẽᛶ⳦ 6 ᰴ
㸦4㸧⮫ᗋ᎘Ẽᛶ⳦࡟ࡘ࠸࡚ࡢㅮ⩦఍㛤ദ௒᪥ࡢ኱Ꮫ་Ꮫ㒊࡟࠾ࡅࡿឤᰁ⑕Ꮫࡢㅮ⩏ࡀෆ⛉Ꮫࡢㅮ⩏඲య࡟༨ࡵࡿ๭ྜࡣࠊᴟࡵ࡚ᑡ࡞࠸ࡇ࡜ࡀ
ࢃ࠿ࡗ࡚࠸ࡿࠋࡲࡓࠊឤᰁ⑕Ꮫࡢ୰࡛ࡶࠊ᎘Ẽᛶ⣽⳦Ꮫ࡟㛵ࡍࡿㅮ⩏ࡢ༨ࡵࡿ๭ྜࡣࡉࡽ࡟ᴟࡵ࡚ᑡ࡞
ࡃࠊࡑࡢᩍ⫱ࡢ࡯࡜ࢇ࡝ࡣࠊ༞ᚋᩍ⫱࡟౫Ꮡࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸⌧≧࡛࠶ࡿࠋ᳨ᰝᢏᖌࡢᩍ⫱࡟㛵ࡋ࡚ࡶྠᵝࡢࡇ࡜ࡀゝ࠼ࡿࠋ᎘Ẽᛶ⣽⳦Ꮫ࡜᎘Ẽᛶ⳦ឤᰁ⑕ࡢ༞ᚋᩍ⫱࡟࠾ࡅࡿᮏ᪋タࡢᙺ๭ࡣࠊࢃࡀᅜ࡟
࠾࠸࡚ᴟࡵ࡚኱ࡁ࠸࡜⪃࠼ࡽࢀࡿࠋ
᎘Ẽᛶ⳦ឤᰁ⑕ࡣࠊෆ⛉ࠊእ⛉ࠊᩚᙧእ⛉ࠊ⏘፬ே⛉ࠊ⪥㰯ဗႃ⛉ࠊṑ⛉ཱྀ⭍እ⛉࡞࡝ᖜᗈ࠸㡿ᇦ࡛ぢࡽࢀࠊ᎘Ẽᛶ⳦ࡢ⮫ᗋ᳨ᰝࡣឤᰁ⑕ࡢデ᩿࣭἞⒪࡟㔜せ࡛࠶ࡿࠋᮏࢭ࣑ࢼ࣮ࡣࠊ᎘Ẽᛶ⳦࠾ࡼࡧ᎘Ẽᛶ⳦ឤᰁ⑕࡟⯆࿡ࡢ࠶ࡿ᪉ࠎ࡟ࠊ᭱᪂ࡢ᝟ሗࢆ஺࠼ࡓ඲⯡ⓗ࡞▱㆑࡜᳨ᰝ࡟㛵ࢃࡿᢏ⾡ࢆ⩦ᚓࡋ࡚㡬ࡃࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚ㅮ⩏࡜ᐇ⩦ࢆᐇ᪋ࡋ࡚࠸ࡿࠋ

ࠓ➨ 49 ᅇ᎘Ẽᛶ⳦᳨ᰝࢭ࣑ࢼ࣮ࠔࡲ࡛ࠊ⥲ཧຍேᩘ㸸⣙ 1747 ྡࠓ➨ 50 ᅇ᎘Ẽᛶ⳦᳨ᰝࢭ࣑ࢼ࣮ࠔ
㛤ദᮇ㛫㸸௧࿴ 3 ᖺ 7 ᭶ 30 ᪥㸦㔠㸧㹼8 ᭶ 1 ᪥㸦᪥㸧 㸦ᐃဨ 20 ྡ㸧ཧຍ⪅㸸22 ྡ㸦་⒪ᶵ㛵 19ࠊ᳨ᰝࢭࣥࢱ࣮2ࠊ௻ᴗ 1㸹⮫ᗋ᳨ᰝ㛵ಀ 20 ྡࠊ⸆๣ᖌ 1 ྡࠊ◊✲⪅ 1㸹9 㒔㐨ᗓ┴㸧

8. ᩍဨࡢ◊✲࣭ᩍ⫱࣭♫఍άື࠙ㄽᩥ➼ࠚཎⴭ㸦Ḣᩥ㸧
1.

Vu H, Hayashi H, Nguyenn TN, Kong DT, Tran HT, Yamamoto Y, Tanaka K. Comparison ofphenotypic and genotypic patterns of antimicrobial-resistant Bacteroides fragilis group isolatedfrom healthy individual in Vietnam and Japan. Infection and Drug Resistance, 14:5313-5323,(2021)
2.

KimuraI,

Vu

H,

TanakaK.

Multiplicity

of

antimicrobial anti-inflammatory andanti-proliferative effects with a combined formulation of extracts of Bamboo Leaf, Red Pine
Needle Leaf and Ginseng Root. Pharmacometrics,101(3/4);37-44,(2021)
3.

Sano H, Waku A, Hirabuki Y, Kawachi M, Washino J, Abiko Y, Mayanagi G, Yamaki K, Tanaka
K, Takahashi N, Sato T. Profiling system of oral microbiota utilizing polymerase chain
reaction-restriction fragment length polymorphism analysis. Journal of Oral Biosciences.
63(3):292-297,(2021)

4.

Wakui A, Sano H, Kawachi M, Aida A, Takenaka Y, Yonezawa A, Nakahata N, Moriyama S,
Nishikatab M, Washio J, Abiko Y, Mayanagi G, Yamaki K, Sakashita R, Tanaka K, Takahashi
N, Sato T. Bacterial concentration and composition in liquid baby formula and a baby drink
consumed with an artificial nipple. Journal of Oral Biosciences. 63:161-168,(2021)

5.

Wakui A, Sano H, Hirabuki , Kawachi M, Aida A, Washio J, Abiko Y, Mayanagi G, Yamaki K,
Tanaka K, Takahashi and Sato T. Profiling of Microbiota at the Mouth of Bottles and in
Remaining Tea after Drinking Directly from Plastic Bottles of Tea. Dentistry journal. 9(6),58,(2021)

6.

Tanaka K, Vu H, Hayashi M. In vitro activities and spectrum of lascufloxacin㸦KRP-AM1977㸧
against anaerobes. Journal of Infection and Chemotherapy. 27:1265-1269,(2021)

࠙Ꮫ఍ࠚ
ᅜ㝿Ꮫ఍
1. World Microbe Forum 2021㸦௧࿴ 3 ᖺ 6 ᭶ 20㹼24 ᪥, WEB, ࣏ࢫࢱ࣮ࢭࢵࢩࣙࣥࠕCharacterizationof cODVV'ǃ-lactamase from Bacteroides fragilis GAI92214, a strain intermediately resistant tocarbapenemsࠖ₇⪅㸧Goto T, Hayashi M, Morita Y, Tanaka K.

ᅜෆᏛ఍
1. ➨ 50 ᅇ᪥ᮏ᎘Ẽᛶ⳦ឤᰁ⑕Ꮫ఍⥲఍㸦௧࿴ 3 ᖺ 5 ᭶ 29 ᪥㸪WEB㸪ࢩ࣏ࣥࢪ࣒࢘ ࠕ᎘Ẽᛶ⳦◊✲ࡢ᭱๓⥺ࠖྖ఍㸧⏣୰㤶࠾㔛
2. ➨ 50 ᅇ᪥ᮏ᎘Ẽᛶ⳦ឤᰁ⑕Ꮫ఍⥲఍㸦௧࿴ 3 ᖺ 5 ᭶ 29 ᪥㸪WEB㸪ࢩ࣏ࣥࢪ࣒࢘ ࠕ᎘Ẽᛶ⳦◊✲ࡢ᭱๓⥺ࠖ-ࠕMALDI-TOF MS ࢆ⏝࠸ࡓ Fusobacterium ᒓࡢள✀ྠᐃ࡟㛵ࡍࡿ᳨ウࠖ₇⪅㸧ᯘᑗ኱

3. ➨ 69 ᅇ᪥ᮏ໬Ꮫ⒪ἲᏛ఍す᪥ᮏᨭ㒊⥲఍࣭➨ 64 ᅇ᪥ᮏឤᰁ⑕Ꮫ఍୰᪥ᮏᆅ᪉఍Ꮫ⾡㞟఍࣭➨ 91ᅇ᪥ᮏឤᰁ⑕Ꮫ఍す᪥ᮏᆅ᪉఍Ꮫ⾡㞟఍㸦௧࿴ 3 ᖺ 11 ᭶㸪ᒱ㜧ᕷ㸪ᩍ⫱ㅮ₇ 11ࠕᚤ⏕≀ศ㔝࡟࠾ࡅࡿḟୡ௦ࢩ࣮ࢡ࢚ࣥࢫࡢά⏝ࠖྖ఍ࠊࢫ࢖࣮ࢶࢭ࣑ࢼ࣮3ࠕ࿧྾ჾឤᰁ⑕ࠊ⪥㰯ဗႃ⛉ឤᰁ⑕᳨࡛ฟࡉࢀࡿ᎘Ẽᛶ⳦ࠖ ₇⪅㸧⏣୰㤶࠾㔛
4. ➨ 33 ᅇ᪥ᮏ⮫ᗋᚤ⏕≀Ꮫ఍⥲఍(௧࿴ 4 ᖺ 1 ᭶ 29 ᪥ࠥ3 ᭶ 31 ᪥, ௝ྎᕷ, ᩍ⫱ㅮ₇ 11ࠕ࡝ࡇࡀ࣏
࢖ࣥࢺ㸽 ᎘Ẽᛶ⳦ 㸫ຠ⋡ࡼࡃ⮫ᗋ࡟ά࠿ࡍࡓࡵ࡟㸫ࠖ₇⪅ࠊࢩ࣏ࣥࢪ࣒࢘ 7ࠕ᎘Ẽᛶ⳦᳨ᰝࡢ
ὀពⅬ࡜ឤᰁ⑕ࠖྖ఍) ⏣୰㤶࠾㔛
5. ➨ 33 ᅇ᪥ᮏ⮫ᗋᚤ⏕≀Ꮫ఍⥲఍(௧࿴ 4 ᖺ 1 ᭶ 29 ᪥ࠥ3 ᭶ 31 ᪥, ௝ྎᕷ,ࢩ࣏ࣥࢪ࣒࢘ 7ࠕ᎘Ẽᛶ⳦᳨ᰝࡢὀពⅬ࡜ឤᰁ⑕ࠖ₇⪅) ᯘᑗ኱ཷ㈹᪥ᮏ᎘Ẽᛶ⳦ឤᰁ⑕Ꮫ఍ ᴟᮾ〇⸆㈹ࠕMALDI-TOF MS ࢆ⏝࠸ࡓ Fusobacterium ᒓࡢள✀ྠᐃ࡟㛵ࡍࡿ᳨ウࠖ ᯘᑗ኱࠙ඹྠ◊✲ࠚ1 ௳ ᎘Ẽᛶ⳦ಖᏑ㍺㏦ᐜჾࡢホ౯ヨ㦂 㸦┴እ௻ᴗ㸧௧࿴ 3 ᖺ 12 ᭶㹼௧࿴ 4 ᖺ 5 ᭶࠙ᩍ⫱ศᢸࠚ
⏣୰㤶࠾㔛㸸㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉㸦ే௵㸧་Ꮫ㒊་Ꮫ⛉ ࢸ࣮ࣗࢺࣜ࢔ࣝ ࢸ࣮ࣗࢱ࣮
་Ꮫ㒊་Ꮫ⛉ 㑅ᢥࢸ࣮ࣗࢺࣜ࢔ࣝ
඲Ꮫඹ㏻ᩍ⫱

ㅮ⩏་Ꮫ㒊┳ㆤᏛ⛉ ㅮ⩏ᚋ⸨ 㝯ḟ㸸་Ꮫ㒊་Ꮫ⛉ࢸ࣮ࣗࢺࣜ࢔ࣝ ࢸ࣮ࣗࢱ࣮

་Ꮫ㒊་Ꮫ⛉ 㑅ᢥࢸ࣮ࣗࢺࣜ࢔ࣝᯘ ᑗ኱㸸་Ꮫ㒊་Ꮫ⛉ࢸ࣮ࣗࢺࣜ࢔ࣝ ࢸ࣮ࣗࢱ࣮

་Ꮫ㒊་Ꮫ⛉ 㑅ᢥࢸ࣮ࣗࢺࣜ࢔ࣝ

ື≀ᐇ㦂ศ㔝
Division of Animal Experimentࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : lsrcanim@gifu-u.ac.jp
TEL : 058-230-6608
FAX : 058-230-6044

┠‫ ی‬ศ㔝㛗ᣵᣜḟ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ື≀ᐇ㦂ศ㔝⤌⧊࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭




 ື≀ᐇ㦂ศ㔝⫋ဨ ື≀ᐇ㦂ศ㔝ἢ㠉 ື≀ᐇ㦂ศ㔝⤂௓࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

 ື≀ᐇ㦂ศ㔝άື⤂௓ ᡤ᭷タഛ㸦ື≀ᐇ㦂᪋タ㸧⤂௓ ฼⏝ࡢᡭᘬࡁ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

 ື≀ᐇ㦂᪋タࢆ౑࠺࡟ࡣ
 ື≀ᐇ㦂チྍ␒ྕࡢྲྀᚓ
 ື≀ᐇ㦂᪋タ฼⏝⪅ㅮ⩦఍ࡢཷㅮ ື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩ࡢᥦฟ
 ື≀ᐇ㦂᪋タ౑⏝ᚰᚓ ᒱ㜧኱Ꮫື≀ᐇ㦂ྲྀᢅつ⛬ ௧࿴  ᖺᗘάືሗ࿌

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

 ฼⏝≧ἣ動物ᐇ㦂᪋タ฼⏝⪅≧ἣᐇ㦂ື≀㣫⫱≧ἣࠉࠉ⾜஦࣭ദ஦ື≀ᐇ㦂᪋タぢᏛ⪅ ㅮ⩦఍࣭ㅮ₇఍࡞࡝฼⏝⪅ㅮ⩦఍ ᴗ⦼ㄽᩥ㞟 ື≀ᐇ㦂᪋タ฼⏝⪅ᴗ⦼ㄽᩥ
 ື≀ᐇ㦂ศ㔝ᩍဨࡢᩍ⫱◊✲άື‫ ی‬ศ㔝㛗ᣵᣜື≀ᐇ㦂ศ㔝㛗 ஧ୖⱥᶞᙜศ㔝ࡀ⟶⌮ࡍࡿື≀ᐇ㦂᪋タࡣࠊࡇࡢ୍ᖺࠊ኱ࡁ࡞ࢺࣛࣈࣝ࡟ぢ⯙ࢃࢀࡿࡇ࡜࡞ࡃ㐠⏝ࡍࡿࡇ࡜ࡀ࡛
ࡁࡲࡋࡓࠋࡇࢀࡶࡦ࡜࠼࡟฼⏝⪅ࡢⓙᵝ᪉ࡢࡈ༠ຊ࡜ࠊᮏ᪋タࢫࢱࢵࣇ㐩ࡢࡀࢇࡤࡾࡢ࠾࠿ࡆ࡛࠶ࡾࡲ
ࡍࠋ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ
௧࿴ 3 ᖺࡣࠊ
୍᫖ᖺ࠿ࡽᘬࡁ⥆ࡁ᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕ࡢᙳ㡪ࢆ኱ࡁࡃཷࡅࡓ୍ᖺ࡜࡞ࡾࡲࡋࡓࠋ
࣡ࢡࢳࣥ࡞࡝ࡢຠᯝࡶ࠶ࡾ᭱㏆࡛ࡣⴠࡕ╔࠸࡚ࡁ࡚࠸ࡲࡍࡀࠊឤᰁࡢἼࡀᐃᮇⓗ࡟᮶࡚࠸ࡿࡇ࡜ࡶ࠶ࡾࠊ
ࡲࡓࠊឤᰁຊࡢ㧗࠸ᰴࡀⓏሙࡋ࡚࠸ࡿࡇ࡜ࡶ࠶ࡾࠊ௧࿴ 4 ᖺ࡟࡞ࡗࡓ⌧ᅾ࡛ࡶ኱ࡁ࡞⊛ጾࢆ㦫␗࡜࡞ࡾࡘ࡙ࡅ࡚࠸ࡲࡍࠋື≀ᐇ㦂᪋タࡶ౛እ࡛ࡣ࡞ࡃࠊ᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕⥭ᛴ஦ែᐉゝࡸࠊࡲࢇᘏ㜵Ṇ➼㔜Ⅼᥐ⨨࡞࡝࡟ࡼࡾࠊ3 ᐦࢆ㑊ࡅࡿࡓࡵࡢᑐ⟇ࢆㅮࡌࡿᚲせࡀ࠶ࡗࡓࡾ࡜ࠊ኱ࡁ࡞ᙳ㡪ࢆཷࡅࡲࡋࡓࠋ
ࡇ࠺ࡋࡓ≧ἣୗ࡟࠶ࡗ࡚ࠊᙜศ㔝࡜ࡋ࡚ࡣࠊ㣫⫱୰ࡢື≀ࡢ⥅⥆ⓗ࡞⥔ᣢࢆ➨୍࡟⪃࠼ࡓ㐠⏝ࢆ┠ᣦࡋ࡚ࡁࡲࡋࡓࠋࡉ࠸ࢃ࠸᪋タ㛢㙐࡞࡝኱ࡁ࡞⿕ᐖࡀฟࡿࡇ࡜ࡶ࡞ࡃ୍ᖺࢆ㐣ࡈࡏࡓࡇ࡜࡟࡯ࡗ࡜ࡋ࡚࠸ࡲࡍࠋ
᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕ࡢ⊛ጾࡣண᩿ࢆチࡋࡲࡏࢇࡀࠊᘬࡁ⥆ࡁࠊ⥭ᙇឤࢆᣢࡗࡓ᪋タࡢ⟶⌮㐠Ⴀ࡟࠶ࡓࡾࡓ࠸࡜ᛮ࠸ࡲࡍࠋ
௒ᚋࡶື≀ᐇ㦂᪋タࡢ㐠Ⴀࢆࢫࢱࢵࣇ୍ྠ㡹ᙇࡿᡤᏑ࡛ࡍࡢ࡛ࡼࢁࡋࡃ࠾㢪࠸ࡋࡲࡍࠋ
௧࿴ 4 ᖺ 4 ᭶1. ື≀ᐇ㦂ศ㔝⤌⧊
1-1㸬ື≀ᐇ㦂ศ㔝⫋ဨ㸦௧࿴ 3 ᖺᗘ㸧(1㸧ᑓ௵ᩍᐁ
1. ᩍᤵ㸦ศ㔝㛗㸧 ஧ୖⱥᶞ
2. ຓᩍ ᇼ஭᭷ᕼ(2㸧ᑓ௵⫋ဨ
1. ᢏᖌ ኱ᒣ㈗அ2. ๪ᢏᖌ ௒ᗘ໷♸(3㸧㠀ᖖ໅⫋ဨ
1. ᢏ⾡⿵బဨ ᯇᒃ࿴⨾2. ᢏ⾡⿵బဨ ᅵᒱ┿⏤⨾3. ஦ົ⿵బဨ ᯇཎ࠿࠾ࡿ
4. ஦ົ⿵బဨ ᚋ⸨⪷Ꮚ

1-2㸬ື≀ᐇ㦂ศ㔝ἢ㠉
ᖹᡂ 5 ᖺ 4 ᭶་Ꮫ㒊௜ᒓື≀ᐇ㦂᪋タタ⨨㸦Ꮫ㒊ෆฎ⨨㸧་Ꮫ㒊ᇶ♏Ჷᒇୖ୰ື≀㣫⫱ᐊ㸦221 ᖹ⡿㸧ᖹᡂ 7 ᖺ 4 ᭶་Ꮫ㒊௜ᒓື≀ᐇ㦂᪋タタ⨨㸦┬௧᪋タ㸧

ᖹᡂ 12 ᖺ㑇ఏᏊ᧯సື≀㣫⫱ᐊ㸦16 ᖹ⡿㸧㐠⏝㛤ጞ

ᖹᡂ 15 ᖺ 4 ᭶⏕࿨⛉Ꮫ⥲ྜᐇ㦂ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝࡟ᨵ⤌

ᖹᡂ 16 ᖺ 12 ᭶་Ꮫ㒊⏕࿨⛉ᏛᲷ᏶ᡂ㸦3 㹼5 㝵㒊ศ࡟᪂ື≀ᐇ㦂᪋タࢆ㓄⨨㸧ᖹᡂ 17 ᖺ 3 ᭶ᪧ་Ꮫ㒊㸦ྖ⏫㸧ᇶ♏Ჷᒇୖ୰ື≀㣫⫱ᐊ㛢㙐ᪧ་Ꮫ㒊㸦ྖ⏫㸧㑇ఏᏊ᧯సື≀㣫⫱ᐊ㛢㙐ᰗᡞᆅ༊࡬⛣㌿

ᖹᡂ 17 ᖺ 4 ᭶⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝࡬ᨵ⛠᪂ື≀ᐇ㦂᪋タ㐠⏝㛤ጞᖹᡂ 30 ᖺ 4 ᭶◊✲᥎㐍࣭♫఍㐃ᦠᶵᵓ ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝࡬ᨵ⛠

௧࿴ 2 ᖺ 4 ᭶㧗➼◊✲㝔 ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝࡬ᨵ⛠

௧࿴ 3 ᖺ 1 ᭶⢾㙐⏕࿨ࢥ࢔◊✲ᡤ ⢾㙐ศᏊ⛉Ꮫ◊✲ࢭࣥࢱ࣮◊✲ᇶ┙㒊㛛ື≀ᐇ㦂ศ㔝ࢆే⛠

2. ື≀ᐇ㦂ศ㔝⤂௓
2-1㸬ື≀ᐇ㦂ศ㔝άື⤂௓ື≀ᐇ㦂ศ㔝࡛ࡣࠊ௨ୗࡢࡼ࠺࡞άືࢆ⾜ࡗ࡚࠸ࡲࡍࠋ
㸦㸯㸧ື≀ᐇ㦂ࡢࡓࡵࡢ᪋タࡢᥦ౪࡜ᢏ⾡ⓗࢧ࣏࣮ࢺ⏕࿨⛉Ꮫࡢ◊✲࡟࠾࠸࡚ࠊື≀ᐇ㦂ࡣᚲせ୙ྍḞ࡛ࡍࠋ◊✲ࡢᚲせ࡟ᛂࡌ࡚ࠊ࣐࢘ࢫࠊࣛࢵࢺࠊ
࢘ࢧࢠࠊࣅ࣮ࢢࣝ≟ࠊࣈࢱ࡞࡝ᵝࠎ࡞ື≀ࡀ◊✲࡟⏝࠸ࡽࢀࡲࡍࠋ㏆ᖺࠊࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐࢘
ࢫࡸࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫ࡟௦⾲ࡉࢀࡿࠊ㑇ఏᏊᨵኚື≀ࡀ኱ኚὀ┠ࡉࢀ࡚࠸ࡲࡍࠋື≀ᐇ㦂࠿ࡽಙ㢗࡛ࡁࡿࢹ࣮ࢱࢆᚓࡿࡓࡵ࡟ࡣࠊᐇ㦂ື≀ࡀᏳᐃࡋࡓ⎔ቃ࡛Ⰻࡃ⟶⌮ࡉࢀ࡚࠸ࡿࡇ࡜ࡀᚲせ࡛ࡍࠋࡲࡓࠊே㛫࡟ᑐࡍࡿᏳ඲࡬ࡢ㓄៖ࡸ⏕࿨೔⌮ࡢ❧ሙ࠿ࡽࠊ࣮ࣝࣝ࡟ᇶ࡙࠸ࡓᐇ㦂ࢆ⾜࠺ࡇ࡜ࡀồࡵࡽࢀࡲࡍࠋᮏࢭࣥࢱ࣮ࡢື≀ᐇ㦂ศ㔝ࡣࠊື≀ᐇ㦂࡟㛵ࡍࡿ᪋タࢆᥦ౪ࡍࡿ࡜࡜ࡶ࡟ື≀ᐇ㦂ࡢィ⏬❧᱌ࠊື≀ࡢ⥔ᣢ⟶⌮࡟㛵ࡍࡿ⥲ྜⓗ࡞ࢧ࣏࣮ࢺࢆ⾜࠸ࡲࡍࠋ㸦㸰㸧ື≀ᐇ㦂࡟ࡘ࠸࡚ࡢᩍ⫱ᣦᑟື≀ᐇ㦂ࢆ⾜࠺ࡓࡵ࡟ࡣࠊᐇ㦂࡟ඛ❧ࡕከࡃࡢᑓ㛛ⓗ▱㆑ࡸᡭᢏ➼ࢆ࣐ࢫࢱ࣮ࡍࡿࡇ࡜ࡀᚲせ࡛ࡍࠋື≀ᐇ㦂ศ㔝࡛ࡣᏛෆࡢ◊✲⪅࡟ᑐࡋື≀ᐇ㦂࡟ࡘ࠸࡚ࡢㅮ⩦఍ࢆ⾜ࡗ࡚࠸ࡲࡍࠋࡲࡓࠊᐇ㦂ィ⏬᭩ᑂᰝ࡞࡝ࢆ㏻ࡋࠊື≀ᐇ㦂࡟࠾ࡅࡿᐇ㦂ィ⏬సᡂࠊᐇ㦂ື≀ࡢ㑅ᢥ࠿ࡽື≀ࡢྲྀࡾᢅ࠸᪉ࠊ
㣫⫱⎔ቃࠊ㣫⫱᪉ἲࠊᏳᴦṚἲ➼࡟ࡘ࠸࡚ࡢᩍ⫱࡜ࢥࣥࢧࣝࢸ࢕ࣥࢢࢆ⾜࠸ࡲࡍࠋ㸦㸱㸧ᐇ㦂ື≀Ꮫⓗ◊✲ࠊⓎ⏕ᕤᏛⓗᡭἲࢆ⏝࠸ࡓື≀ᐇ㦂ࡢࢧ࣏࣮ࢺ
⑓ࡢⱞࡋࡳ࠿ࡽ㏨ࢀ೺ᗣ࡛࠶ࡾࡓ࠸࡜ࡢ㢪࠸࡜ࠊ⏕࿨ᶵ⬟ࢆ▱ࡾࡓ࠸࡜࠸࠺ᛮ࠸ࡀࣛ࢖ࣇࢧ࢖࢚
ࣥࢫࡢⓎᒎࢆಁࡋࠊ௒᪥ࡢ་Ꮫ࣭⏕࿨⛉Ꮫࢆ⠏࠸࡚ࡁࡲࡋࡓࠋࡋ࠿ࡋࠊ⏕࿨⌧㇟ࡢㅦࡣ࡜࡚ࡘࡶ࡞ࡃ῝ࡃࠊ࠸ࡲࡔከࡃࡢ㞴ၥࡀṧࡉࢀ࡚࠸ࡲࡍࠋࣛ࢖ࣇࢧ࢖࢚ࣥࢫࢆᨭ࠼࡚ࡁࡓື≀ᐇ㦂ࡶከᵝ໬ࡋࠊ㧗ᗘ࡞ᑓ㛛ᛶࡀồࡵࡽࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁࡲࡋࡓࠋࡇࡢࡼ࠺࡞㞴ၥ࡟ᣮᡓࡍࡿࡓࡵ࡟ࠊ㑇ఏᏊᨵኚື≀㸦ࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐࢘ࢫࡸࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫ㸧ࡢసฟࠊ⬇ᛶᖿ⣽⬊࠿ࡽࡢ≉ᐃ⣽⬊࡬ࡢ
ศ໬࡞࡝Ⓨ⏕ᕤᏛⓗᡭἲࢆ⏝࠸ࡓ◊✲ࢆ┠ᣦࡋ࡚࠸ࡲࡍࠋ



2-2㸬ᡤ᭷タഛ㸦ື≀ᐇ㦂᪋タ㸧⤂௓ᮏື≀ᐇ㦂᪋タࡣࠊᖹᡂ 17 ᖺ᫓ࡼࡾ㐠⏝ࢆ㛤ጞࡋࡓࠊẚ㍑ⓗ᪂ࡋ࠸᪋タ࡛ࡍࠋᖹᡂ 16 ᖺ࡟་Ꮫ㒊࡜኱Ꮫ⑓㝔ࡀࠊྖ⏫࢟ࣕࣥࣃࢫ࠿ࡽ኱Ꮫᮏ㒊ࡢ࠶ࡿᰗᡞ࢟ࣕࣥࣃࢫ࡬⛣㌿ࡋࡓᢡࡾ࡟ࠊࡇࢀࡽࡢᘓ≀࡟㞄᥋ࡋ࡚་Ꮫ㒊⏕࿨⛉ᏛᲷࡀᘓタࡉࢀࠊࡑࡢ୰࡟タ⨨ࡉࢀࡲࡋࡓࠋ་Ꮫ㒊⏕࿨⛉ᏛᲷࡣ」ᩘࡢ㒊ᒁࡀධᒃࡍࡿྜྠ᪋タ࡛ࠊᖹᡂ 16 ᖺ 12 ᭶ 20 ᪥࡟❹ᕤࡋࡓᘓ≀ࡣࠊ5 㝵ᘓ࡚ࠊᘏ࡭ᗋ㠃✚⣙ 6582.16 ᖹ⡿ࢆ᭷ࡋࡲࡍࠋࡇࡢ୰࡟ࠊ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࡜་Ꮫ㒊ࡢ኱ᆺᶵჾ୪ࡧ࡟タഛࡀタ⨨ࡉࢀࠊᒱ㜧኱Ꮫ࡟࠾ࡅࡿ
⏕࿨⛉Ꮫศ㔝ࡢ◊✲άື࡟኱ࡁࡃᐤ୚ࡍࡿࡇ࡜ࡀᮇ
ᚅࡉࢀ࡚࠸ࡲࡍࠋ
ࡇࡢᲷࡢ 3 㝵࠿ࡽ 5 㝵࡟ࡣྠࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝ື≀ᐇ㦂᪋タࡀධᒃࡋ࡚࠸ࡲࡍࠋᒱ㜧኱Ꮫ࡜ࡋ࡚
ࡣึࡵ࡚࡜࡞ࡿࣂࣜ࢔ࢩࢫࢸ࣒ࢆ⿦ഛࡋࡓ㏆௦ᆺࡢ኱ᆺື≀ᐇ㦂᪋タ࡛ࡍࠋື≀᪋タ࡜ࡋ࡚ࡇࢀࡲ࡛࡟ẚ࡭ࠊᪧ࢟ࣕࣥࣃࢫ་
Ꮫ㒊Ჷෆ࡟ᩓᅾࡋ࡚࠸ࡓ㣫⫱タഛࡀ୰ኸ㞟⣙໬ࡉࢀ୍ඖ⟶⌮ࡉࢀࡿ࡜࡜ࡶ࡟ࠊ㣫⫱ᐊࢫ࣮࣌ࢫࡶ኱ᖜ࡟
ᣑ኱ࡋࡲࡋࡓࠋ᪂ື≀ᐇ㦂᪋タࡣࠊ4 ࡘ࡟ศ࠿ࢀࡓ
㣫⫱ᐊ࢚ࣜ࢔ࢆ᭷ࡋ࡚࠾ࡾࠊSPF ᑠື≀㣫⫱ᐊࠊࢡ࣮ࣜࣥᑠື≀㣫⫱ᐊࠊ୰ື≀㣫⫱ᐊࠊឤᰁື≀㣫⫱ᐊ࠿ࡽᵓᡂࡉࢀ࡚࠸ࡲࡍࠋࡑࡋ࡚ࡇࢀࡽࡢ㣫⫱ᐊ࡟ຍ࠼ࠊྛᐇ㦂ᐊࠊ୰ື≀⏝ᡭ⾡ᐊ࡞࡝ࢆಖ᭷ࡋ࡚࠸
ࡲࡍࠋࡲࡓ඲ᐊ P1A ࡟ࡣᑐᛂࡋ࡚࠸ࡿࡢ࡛ࠊ㑇ఏᏊ⤌᥮࠼ື≀ࡢ㣫⫱㠃✚ࡶቑ࠼ࡲࡋࡓࠋࡇࢀࡲ࡛ࡢ᪋
タ࡟ẚ࡭ࠊ᪂ࡓ࡟ SPF ື≀ࢆ⏝࠸ࡓᐇ㦂ࠊP2/P3 ࢡࣛࢫࡢឤᰁື≀ᐇ㦂ࠊ㑇ఏᏊ⤌᥮࠼ື≀ࡢసᡂ࡞࡝
ࡀ࡛ࡁࡿࡼ࠺࡟࡞ࡾࡲࡋࡓࠋ
ࡲࡓࠊᑠື≀㣫⫱ᐊ࡟ࡣࠊ඲ᐊࠊಶู᥮Ẽᆺࢣ࣮ࢪࣥࢢࢩࢫࢸ࣒ࢆᑟධࡋࡓࡢࡶࠊᮏ᪋タࡢ≉ᚩ࡛ࡍࠋࡇࢀ࡟ࡼࡾࠊ1 㣫⫱ᐊ࠶ࡓࡾࡢ཰ᐜྍ⬟㢌ᩘࡣ኱ࡁࡃቑ࠼ࠊື≀ᐇ㦂᪋タ࡛ၥ㢟࡜࡞ࡾࡸࡍ࠸୙㊊Ẽ࿡ࡢ㣫⫱ᐊ㠃✚࡟ࡶᑐᛂ࡛ࡁࡿࡼ࠺࡟࡞ࡾࡲࡋࡓࠋ
ື≀ᐇ㦂᪋タࡣࠊᖹᡂ 15 ᖺ࡟ᨵ⤌ࡉࢀࠊ་Ꮫ㒊ࡢ㝃ᒓ᪋タ࠿ࡽࠊᒱ㜧኱Ꮫࡢඹྠ฼⏝᪋タ࡜ࡋ࡚ࢭࣥࢱ࣮໬ࡉࢀࡲࡋࡓࠋ⌧ᅾࡲ࡛ࡢᡤࠊᒱ㜧኱Ꮫෆࡢ⪅࡛࠶ࢀࡤࠊ➼ࡋࡃ౑࠺ࡇ࡜ࡀ࡛ࡁࡲࡍࠋ
ື≀ᐇ㦂᪋タࡢ฼⏝ࢆᕼᮃࡉࢀࡿ᪉ࡣࠊ❶ᮎࠕ฼⏝ࡢᡭᘬࡁࠖࢆཧ↷࡟ࡋ࡚ࡃࡔࡉ࠸ࠋࡲࡓࠊྠᵝࡢෆᐜࡢࡇ࡜ࡀ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝࣮࣒࣮࣍࣌ࢪ㸦http://www1.gifu-u.ac.jp/~lsrc/㸧࡟ࡶᥖ㍕ࡉࢀ࡚࠸ࡲࡍࠋ

㸦ື≀ᐇ㦂ศ㔝ᡤ᭷タഛ㸧ື≀ᐇ㦂᪋タ㸦་Ꮫ㒊⏕࿨⛉ᏛᲷෆ㸧཰ᐜ⬟ຊ

1. SPF ᑠື≀㣫⫱࢚ࣜ࢔(࢔) ࣐࢘ࢫ⏝ࢣ࣮ࢪ㸭1728(࢖) ࣛࢵࢺ⏝ࢣ࣮ࢪ㸭192
2. ࢡ࣮ࣜࣥᑠື≀㣫⫱࢚ࣜ࢔(࢘) ࣐࢘ࢫ⏝ࢣ࣮ࢪ㸭2304(࢚) ࣛࢵࢺ⏝ࢣ࣮ࢪ㸭256୰ື≀㣫⫱࢚ࣜ࢔(࢜) ᡭ⾡ᐊ 4(࢝) ࢘ࢧࢠ㣫⫱ᐊձ ࢘ࢧࢠ⏝ࢣ࣮ࢪ㸭60(࢟) ࣑ࢽࣈࢱ㣫⫱ᐊձ ࣑ࢽࣈࢱ⏝ࢣ࣮ࢪ㸭6(ࢡ) ࢖ࢾ㣫⫱ᐊձ ࢖ࢾ⏝ࢣ࣮ࢪ㸭7(ࢣ) ࢧࣝ㣫⫱ᐊձ ࢧࣝ⏝ࢣ࣮ࢪ㸭3ឤᰁື≀㣫⫱࢚ࣜ࢔(ࢥ) P2 ឤᰁື≀ᐇ㦂ᐊձ ࢔࢖ࢯ࣮ࣞࢩࣙࣥ BOX㸭64(ࢧ) P3 ឤᰁື≀ᐇ㦂ᐊձ ࢔࢖ࢯ࣮ࣞࢩࣙࣥ BOX㸭643. ฼⏝ࡢᡭᘬࡁ3-1. ື≀ᐇ㦂᪋タࢆ౑࠺࡟ࡣ
ື≀ᐇ㦂᪋タࢆ⟶㎄ࡍࡿື≀ᐇ㦂ศ㔝ࡣࠊᖹᡂ 15 ᖺᗘࡼࡾ඲Ꮫࡢඹ㏻฼⏝᪋タ࡜࡞ࡾࡲࡋࡓࠋᰗᡞ
࢟ࣕࣥࣃࢫ་Ꮫ㒊⏕࿨⛉ᏛᲷ࡟᪂ࡋࡃ࡛ࡁࡓື≀ᐇ㦂᪋タࡶࠊᏛෆࡢ⪅࡞ࡽࡤࠊ➼ࡋࡃ౑⏝ࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋ
ࡋ࠿ࡋ࡞ࡀࡽࠊື≀ᐇ㦂᪋タ࡛ᐇ㦂ࢆ⾜࠺࡟ࡣࠊ࠶ࡽ࠿ࡌࡵỴࡵࡽࢀࡓᡭ⥆ࡁࢆ⤒ࡿᚲせࡀ࠶ࡾࡲࡍࠋ࠸ࡁ࡞ࡾࠊື≀ࢆᣢࡗ࡚ࡇࡽࢀ࡚ࡶᐇ㦂ࡣ࡛ࡁࡲࡏࢇࠋᒱ㜧኱Ꮫ࡟࠾ࡅࡿື≀ᐇ㦂ࡣࠊᅜࡢ㛵㐃ἲつࠊᣦ㔪࡟ຍ࠼ࠊ
ࠕᒱ㜧኱Ꮫື≀ᐇ㦂ྲྀᢅつ⛬ࠖ࡟ᚑࢃ࡞ࡅࢀࡤ࡞ࡾࡲࡏࢇࠋࡉࡽ࡟ࠊྛ㒊ᒁ࡟ᐇ㦂ྲྀᢅつ๎ࡀ࠶ࡿሙྜࡣࡑࢀ࡟ᚑ࠺ᚲせࡀ࠶ࡾࡲࡍࠋ

ື≀ᐇ㦂᪋タࢆ౑࠺࡟ࡣࠊ஦๓࡟ࠊᚲࡎ௨ୗࡢ 3 ࡘࡢ㡯┠ࡣ‶ࡓࡋ࡚࠸ࡿᚲせࡀ࠶ࡾࡲࡍࠋձ ື≀ᐇ㦂チྍ␒ྕࡢྲྀᚓ㸸ᒱ㜧኱Ꮫ࡛ື≀ᐇ㦂ࢆ⾜࠺ሙྜ࡟ᚲせղ ື≀ᐇ㦂᪋タ฼⏝⪅ㅮ⩦఍ࡢཷㅮ㸸ື≀ᐇ㦂᪋タࢆ฼⏝ࡋ࡚ᐇ㦂ࢆ⾜࠺ணᐃࡢே࡟ᚲせճ ື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩ࡢᥦฟ㸸ᐇ㝿࡟ື≀ᐇ㦂᪋タ࡟ື≀ࢆᦙධࡍࡿணᐃࡢே࡟ᚲせ㸬ື≀ᐇ㦂チྍ␒ྕࡢྲྀᚓ
ᒱ㜧኱Ꮫ࡟࠾࠸࡚ື≀ᐇ㦂ࢆ⾜࠺㝿࡟ࡣࠊ௨ୗࡢࡼ࠺࡞Ỵࡵࡽࢀࡓᡭ㡰ࢆ⤒ࡿᚲせࡀ࠶ࡾࡲࡍࠋ
ྛ✀᭩㢮ࡢᥦฟࠊᑂᰝ➼ࡀᚲせ࡛ࡍࠋࠝື≀ᐇ㦂ᑂᰝ⏦ㄳ᭩ࠊィ⏬᭩➼ࡢᥦฟ࠿ࡽᐇ㦂㛤ጞ㎾ࡢὶࢀ୍ࠞ⯡ⓗ࡞ὶࢀࡣࠊᅗࡢᕥഃ࡜࡞ࡾࡲࡍࠋྛ㒊ᒁࡢື≀ᐇ㦂ጤဨ఍࡬ື≀ᐇ㦂ィ⏬᭩ࢆᥦฟࠊᑂᰝᚋࠊ
ື≀ᐇ㦂チྍ␒ྕࢆᚓࡿᚲせࡀ࠶ࡾࡲࡍࠋጤဨ఍࡛ࡣࠊື≀ឡㆤἲ࡞࡝࡟ᐃࡵࡽࢀࡓෆᐜ࡟ᇶ࡙ࡁࠊ
ᐇ㦂ࡢ㐺ṇࡉࡀᑂᰝࡉࢀࡲࡍࠋ
ࡲࡓࠊ㑇ఏᏊ⤌ࡳ᥮࠼ື≀ࡸࠊ⑓ཎయࡢື≀࡬ࡢ᥋✀ᐇ㦂㸦ឤᰁື≀ᐇ㦂㸧ࢆ⾜࠺ࡇ࡜ࢆணᐃࡋ࡚
࠸ࡿ◊✲⪅ࡣࠊᒱ㜧኱Ꮫࡢ⤌᥮࠼ DNA Ᏻ඲ጤဨ఍ࡸ⑓ཎయ➼Ᏻ඲⟶⌮ဨ఍࡬㛵㐃᭩㢮ࡢ஦๓ࡢᥦฟࡀᚲせ࡟࡞ࡾࡲࡍࠋࡇࡕࡽࡢጤဨ఍࡛ࡣࠊ࢝ࣝࢱ࣊ࢼἲ㸦㑇ఏᏊ⤌᥮࠼⏕≀ἲ㸧ࡸឤᰁ⑕ண㜵ἲ࡞࡝ࠊ㛵㐃ἲつ࡟ᇶ࡙࠸ࡓᑂᰝࡀ⾜ࢃࢀࡲࡍࠋ

 ື≀ᐇ㦂᪋タ฼⏝⪅ㅮ⩦఍ࡢཷㅮື≀ᐇ㦂ࢆ⾜࠺ሙྜ࡟ࠊྛ㒊ᒁ୺ദࡢື≀ᐇ㦂ᚑ஦⪅ㅮ⩦఍ࢆཷࡅࡿᚲせࡀ࠶ࡾࡲࡍࠋࡉࡽ࡟ࠊື
≀ᐇ㦂ࢆ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࡢື≀ᐇ㦂᪋タࢆ౑ࡗ࡚⾜࠺ሙྜ࡟ࡣࠊ஦๓࡟᪋タࡢ฼⏝࢞࢖ࢲࣥࢫ
࡟࠶ࡓࡿㅮ⩦఍ࢆཷㅮࡍࡿᚲせࡀ࠶ࡾࡲࡍࠋㅮ⩦఍࡟ࡣࠊ౑⏝ࡍࡿ㣫⫱ᐇ㦂ᐊ࡟ᛂࡌ࡚ࠊࠕື≀ᐇ㦂᪋タ฼⏝⪅ㅮ⩦఍ࠖࠕື≀ᐇ㦂᪋タ SPF ື≀࢚ࣜ࢔฼⏝⪅ㅮ⩦఍ࠖࠕື≀ᐇ㦂᪋タឤᰁᐇ㦂࢚ࣜ࢔฼⏝⪅ㅮ⩦఍ࠖࡢ୕ࡘࡀ⏝ពࡉࢀ࡚࠸ࡲࡍࠋ
ࡇࡢ࠺ࡕࠊࠕື≀ᐇ㦂᪋タ฼⏝⪅ㅮ⩦఍ࠖࡣ඲ဨᚲಟ࡛ࡍࠋࡉࡽ࡟ᚲせ࡟ᛂࡌ࡚ࠊ
ࠕື≀ᐇ㦂᪋タ SPF
ື≀࢚ࣜ࢔฼⏝⪅ㅮ⩦఍ࠖࠕື≀ᐇ㦂᪋タឤᰁᐇ㦂࢚ࣜ࢔฼⏝⪅ㅮ⩦఍ࠖࢆཷㅮࡍࡿࡇ࡜࡟࡞ࡾࡲࡍࠋ
ࡇࢀࡽࡢㅮ⩦఍ࢆཷㅮࡍࡿࡇ࡜࡟ࡼࡾࠊື≀ᐇ㦂᪋タࡢ฼⏝ࡀྍ⬟࡜࡞ࡿ࡜ྠ᫬࡟ࠊධ㤋ド㸦IC ࣮࢝ࢻ㸧ࡢⓎ⾜⏦ㄳࡀ⾜࠼ࡿࡼ࠺࡟࡞ࡾࡲࡍࠋ

 ື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩ࡢᥦฟ
3-1-1 ࡢࣉࣟࢭࢫࢆ⤒࡚ᐇ㦂チྍ␒ྕࢆ஺௜ࡉࢀࡿ࡜ࠊື≀ᐇ㦂ࡀྍ⬟࡜࡞ࡾࡲࡍࠋື≀ᐇ㦂᪋タࢆ฼⏝ࡍࡿ㝿࡟ࡣࠊࡇࡢᐇ㦂チྍ␒ྕࢆグධࡋࡓື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩ࢆᥦฟࡋ࡚ࡶࡽ࠸ࡲࡍࠋ
ື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩ࡣࠊ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝࣮࣒࣮࣍࣌ࢪ㸦http://www1.gifuu.ac.jp/~lsrc/dae/㸧ࡼࡾࠊPDF ࣇ࢓࢖ࣝࡢᙧ࡛ࢲ࣮࢘ࣥࣟࢻࡀྍ⬟࡛ࡍࡢ࡛ࠊࡈ฼⏝ୗࡉ࠸ࠋ

3-2. ື≀ᐇ㦂᪋タ౑⏝ᚰᚓࡇࡢ౑⏝ᚰᚓࡣ㸪ᒱ㜧኱Ꮫື≀ᐇ㦂ྲྀᢅつ⛬㸦௨ୗࠕつ⛬ࠖ࡜࠸࠺ࠋ㸧࡟๎ࡾ㸪ྛ㒊ᒁ࡛ᑂᰝ஢ᢎࡉࢀ
ࡓື≀ᐇ㦂ࢆ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝ື≀ᐇ㦂᪋タ㸦௨ୗࠕື≀ᐇ㦂᪋タࠖ࡜࠸࠺ࠋ㸧࡟࠾࠸࡚⾜࠺ሙྜࡢලయⓗ஦㡯ࢆᐃࡵࡿࡶࡢ࡛࠶ࡿࠋᐇ㦂ᐇ᪋⪅㸪ᐇ㦂ᐇ᪋⿵ຓ⪅㸦௨ୗࠕᐇ㦂ᐇ᪋⪅ࠖ࡜࠸࠺ࠋ㸧ཬࡧ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮⫋ဨ㸦௨ୗࠕࢭࣥࢱ࣮⫋ဨࠖ࡜࠸࠺ࠋ
㸧ࡣ㸪㐺ṇ࡞ື≀ᐇ㦂ࡀ࡛ࡁࡿࡼ
࠺࡟ࡍࡿ࡜࡜ࡶ࡟㸪᪋タࡢ෇⁥࡞⟶⌮࣭㐠Ⴀࢆᅗࡾ㸪ేࡏ࡚ᐇ㦂ᐇ᪋⪅┦஫ࡢ౽ᐅࡢࡓࡵ࡟㸪ᐇ㦂ᐇ᪋⪅ࡣື≀ᐇ㦂ࡢィ⏬❧᱌ࡢẁ㝵࠿ࡽつ⛬ཬࡧࡇࡢ౑⏝ᚰᚓࢆ㑂Ᏺࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
1 ື≀ᐇ㦂᪋タࡢ౑⏝⪅1㸧ື≀ᐇ㦂᪋タࢆ౑⏝࡛ࡁࡿ⪅ࡣ㸪ᒱ㜧኱Ꮫࡢᩍ⫋ဨ࡞ࡽࡧ࡟Ꮫ⏕㸪ࡑࡢ௚ື≀ᐇ㦂ศ㔝㛗ࡀ౑⏝ࢆㄆࡵࡓ⪅㸦௨ୗࠕ౑⏝⪅ࠖ࡜࠸࠺ࠋ㸧࡛ணࡵື≀ᐇ㦂᪋タࡢ᪋タ฼⏝ㅮ⩦఍ࢆཷㅮࡋⓏ㘓ࡋࡓ⪅
࡜ࡍࡿࠋ
2 ㅮ⩦఍
1㸧ࡍ࡭࡚ࡢ᪋タ฼⏝⪅ࡣࠊ஦๓࡟ࠕື≀ᐇ㦂᪋タ฼⏝⪅ㅮ⩦఍ࠖࢆཷㅮࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋࡇࢀ࡟
ࡼࡾࠊ3 㝵୰ື≀࢚ࣜ࢔ࠊ4 㝵ᑠື≀࢚ࣜ࢔ࡢ฼⏝ࡀྍ⬟࡜࡞ࡿࠋ2㸧5 㝵 SPF ື≀࢚ࣜ࢔ࢆ౑⏝ࡍࡿࡶࡢࡣࠊ2-1㸧ࡢㅮ⩦఍࡟ຍ࠼ࠊ஦๓࡟ࠕື≀ᐇ㦂᪋タ SPF ື≀࢚ࣜ࢔฼⏝⪅ㅮ⩦఍ࠖࢆཷㅮࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
3㸧3 㝵ឤᰁື≀ᐇ㦂࢚ࣜ࢔ࢆ౑⏝ࡍࡿࡶࡢࡣࠊ2-1㸧ࡢㅮ⩦఍࡟ຍ࠼ࠊ஦๓࡟ࠕື≀ᐇ㦂᪋タឤᰁᐇ㦂࢚ࣜ࢔฼⏝⪅ㅮ⩦఍ࠖࢆཷㅮࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
4㸧௨ୖࡢື≀ᐇ㦂᪋タ฼⏝⪅ㅮ⩦఍ࢆཷㅮࡍࡿࡇ࡜࡟ࡼࡾࠊ
ࠕ་Ꮫ㒊⏕࿨⛉ᏛᲷ฼⏝⪅࣮࢝ࢻⓏ㘓⏦ㄳ᭩㸦ᵝᘧ 2㸧ࠖࠕື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩㸦ᵝᘧ 3㸧ࠖࢆ⏦ㄳ࡛ࡁࡿࠋ
5㸧௨ୖࡢㅮ⩦఍ࡣࠊᐃᮇⓗ࡟᪋タ࡟࡚㛤ദࡉࢀ࡚࠸ࡿࠋ
3 ⏕࿨⛉ᏛᲷ฼⏝⪅࣮࢝ࢻ1㸧་Ꮫ㒊⏕࿨⛉ᏛᲷࡢධ㏥ฟࡣࠊࢭ࢟ࣗࣜࢸ࢕ࡢࡓࡵ࣮࢝ࢻࢩࢫࢸ࣒࡟ࡼࡾไ㝈ࡉࢀ࡚࠸ࡿࠋᮏ᪋タ฼⏝⪅࡟㝈ࡽࡎࠊ⏕࿨⛉ᏛᲷࢆ฼⏝ࡍࡿࡶࡢࡣࠊ⏕࿨⛉ᏛᲷ฼⏝⪅࣮࢝ࢻࢆᚲせ࡜ࡍࡿࠋ࣮࢝ࢻ
ࢆྲྀᚓࡍࡿࡓࡵ࡟ࡣࠊ
ࠕ་Ꮫ㒊⏕࿨⛉ᏛᲷ฼⏝⪅࣮࢝ࢻⓏ㘓⏦ㄳ᭩㸦ᵝᘧ 2㸧ࠖࢆ⟶⌮ᐊ࡬ᥦฟࡍࡿࠋ
2㸧⏕࿨⛉ᏛᲷ฼⏝⪅࣮࢝ࢻࡣࠊⓎ⾜⏦ㄳ᭩ࢆᥦฟࡍࡿࡇ࡜࡟ࡼࡾᐇ㈝࡟࡚Ⓨ⾜ࡉࢀࡿࠋ࡞࠾ࠊࡇࡢ
࣮࢝ࢻ࡟࡚ື≀ᐇ㦂᪋タࢆ฼⏝ࡍࡿሙྜ࡟ࡣࠊୖグࠕ2㸬ㅮ⩦఍ࠖࡢཷㅮࡀᚲせ࡜࡞ࡿࠋ฼⏝⪅࣮࢝ࢻࡣ୍ே୍ᯛ࡜ࡋࠊỴࡋ࡚㈚ࡋ೉ࡾࢆࡋ࡚ࡣ࡞ࡽ࡞࠸ࠋ
4 ౑⏝⏦㎸ࡳ࡜౑⏝チྍ
1㸧᪋タ࡟࠾࠸࡚ື≀ᐇ㦂ࢆᐇ᪋ࡋࡼ࠺࡜ࡍࡿ⪅ࡣ㸪ཎ๎࡜ࡋ࡚౑⏝㛤ጞ᪥ࡢ 1 㐌㛫๓ࡲ࡛࡟㸪ྛ㒊ᒁ࡛ᢎㄆࡉࢀࡓࠕື≀ᐇ㦂ィ⏬᭩ࠖࡢチㄆྍ␒ྕ࠾ࡼࡧᚲせ஦㡯ࢆグධࡋࡓࠕື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩ࠖ㸦ᵝᘧ 3㸧ࢆ⟶⌮ᐊ࡟ᥦฟࡍࡿࠋ
2㸧ศ㔝㛗࠶ࡿ࠸ࡣື≀ᐇ㦂⟶⌮⪅࡟ࡼࡾ᪋タࡢ౑⏝チྍࡀ୚࠼ࡽࢀࡓᐇ㦂ᐇ᪋⪅ࡣ㸪⫋ဨࡢᣦ♧࡟ᚑࡗ࡚౑⏝ࡍࡿࠋ
3㸧ᚤ⏕≀ࢆ⏝࠸ࡓឤᰁື≀ᐇ㦂㸪࠶ࡿ࠸ࡣ㑇ఏᏊࢆ⏝࠸ࡓᐇ㦂ཬࡧ㑇ఏᏊᨵኚື≀ᐇ㦂ࡣ㸪Ꮫෆつ⛬ࠊ㛵ಀἲつࡢつไࢆᙉࡃཷࡅࡿࡢ࡛ࠊᚲࡎ㑂Ᏺࡍࡿࠋ
4㸧ேయ࡟༴㝤࡞໬Ꮫ≀㉁➼ࢆ౑⏝ࡍࡿᐇ㦂ࡣ㸪஦๓࡟⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝㛗࡜༑ศ࡟ᡴྜࡏࢆ⾜ࡗࡓୖ࡛⏦ࡋ㎸ࡴࠋ࡞࠾ࠊ⾲ 1 ࡛ᐃࡵࡿ໬Ꮫ≀㉁ࡢ౑⏝ࡣᮏ᪋タ࡛ࡣ࡛ࡁ࡞࠸ࠋ
5㸧ᨺᑕᛶྠ఩ඖ⣲㸦RI㸧ࢆྲྀࡾᢅ࠺ᐇ㦂ࡣ㸪ᮏ᪋タ࡛ࡣᐇ᪋ࡍࡿࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋᏛෆࡢ RI ᪋タ࡟࡚⾜࠺ࡇ࡜ࠋ
⾲1㸦㸯㸧࢝ࢻ࣑࣒࢘ཬࡧࡑࡢ໬ྜ≀㸦㸰㸧ࢩ࢔ࣥ໬ྜ≀㸦㸱㸧᭷ᶵ⇥໬ྜ≀㸦ࣃࣛࢳ࢜ࣥࠊ࣓ࢳࣝࣃࣛࢳ࢜ࣥࠊ࣓ࢳࣝࢪ࣓ࢺࣥཬࡧEPN➼㸧㸦㸲㸧㖄ཬࡧࡑࡢ໬ྜ≀㸦㸳㸧භ౯ࢡ࣒ࣟ໬ྜ≀㸦㸴㸧◉⣲ཬࡧࡑࡢ໬ྜ≀㸦㸵㸧Ỉ㖟ཬࡧ࢔ࣝ࢟ࣝỈ㖟ࠊࡑࡢ௚ࡢỈ㖟໬ྜ≀㸦㸶㸧࣏ࣜࢡࣟࣜࢿ࢖ࢸࢵࢻࣅࣇ࢙ࢽࣝ㸦ูྡ PCB㸧
5 ᪋タ࡬ࡢฟධࡾ
1㸧౑⏝⪅ࡣ㸪⏕࿨⛉ᏛᲷ฼⏝⪅࣮࢝ࢻࢆᚲࡎᦠᖏࡋࠊ᪋タṇ㠃⋞㛵㸦ᮾഃ 2 㝵㸧࠿ࡽฟධࡾࡍࡿࠋ
2㸧᪋タෆ࡛ࡣ㸪⋞㛵࡛ഛ࠼௜ࡅࡢୖᒚࡁ࡟ᒚࡁ᭰࠼㸪ྛ࢚ࣜ࢔ࡢ᭦⾰ᐊ࡛ᑓ⏝ࡢᐇ㦂⾰࡜ᒚࡁ≀࡟᭦⾰ࡍࡿ࡜࡜ࡶ࡟㸪ᾘẘᾮ࡛ᡭᣦࢆᾘẘࡢ࠺࠼㸪࣐ࢫࢡ㸪ᡭ⿄㸪ᖗᏊࢆ╔⏝ࡋ࡚㣫⫱ᐊ࡟ධࡿࠋ
3㸧3 㝵ࠊ4 㝵ࠊ5 㝵ࡢື≀ᐇ㦂࣭㣫⫱࢚ࣜ࢔࡬ࡢධᐊࡣチྍࡉࢀࡓ⪅ࡢࡳྍ⬟࡜࡞ࡿࠋ
6 ࢚࣮ࣞ࣋ࢱ࣮➼ࡢ౑⏝1㸧᪋タࡢ฼⏝⪅ࡣࠊ໭ഃ࢚࣮ࣞ࣋ࢱ࣮ࡢࡳ౑⏝ࡍࡿࠋ2㸧4㸪5 㝵࢚ࣜ࢔ࡢ฼⏝⪅ࡣ༡ഃࡢ࢚࣮ࣞ࣋ࢱ࣮ࡣࠊ౑⏝ࡋ࡚ࡣ࡞ࡽ࡞࠸ࠋ
3㸧3 㝵࢚ࣜ࢔ࡢ฼⏝⪅ࡣࠊື≀ࡢᦙධࠊṚయ㐠ᦙ࡟ࡢࡳ౑⏝ࡍࡿࡇ࡜ࡀྍ⬟࡜ࡍࡿࠋ
7 ື≀ࡢ㉎ධ1㸧ࡇࡢ᪋タ࡛ࡣࠊᐇ㦂ື≀࡜ࡋ࡚⦾Ṫ࣭⏕⏘ࡉࢀࡓື≀ࡋ࠿౑⏝࡛ࡁ࡞࠸ࠋ
2㸧ᕼᮃ⪅ࡣධⲴᕼᮃ᪥ࡢ㸯㐌㛫๓ࡲ࡛࡟ࠕື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩ࠖ㸦ᵝᘧ 3㸧࡟ᚲせ஦㡯ࢆグධࡋࠊ᪋タ࡬ᥦฟࡍࡿࠋ࠾ࡾ࠿࠼ࡋࠊ᪋タ฼⏝チྍࡢྍྰࡀ㐃⤡ࡉࢀࡿࡢ࡛ࠋࡑࢀࢆཷࡅ࡚ᐇ㦂ᐇ᪋⪅ࡣࠊ㉎ධ౫㢗ࢆᴗ⪅࡟⾜࠺ࠋ㉎ධື≀ࡣࠊ┤᥋᪋タ࡬ᦙධࡍࡿࡇ࡜࡜ࡍࡿࠋ
3㸧᪋タ࡛ྲྀࡾᢅ࠺ࡇ࡜ࡢ࡛ࡁࡿື≀ࡣ㸪ື≀ࡢᚤ⏕≀ࢥࣥࢺ࣮ࣟࣝࡢ㠃࠿ࡽḟࡢື≀࡜ࡍࡿࠋձ ᪥ᮏࡢື≀⏕⏘ᴗ⪅࠿ࡽᑟධࡍࡿࣛࢵࢺ㸪࣐࢘ࢫࡣ SPF㸦specific pathogen free㸧ື≀࡜ࡋ㸪ࣛࢵࢺ࡟ࡘ࠸࡚ࡣᖺ 1 ᅇ௨ୖ⭈⑕ೃᛶฟ⾑⇕㸦HFRS㸸Hemorrhagic fever with renal syndrome㸧ᢠయ᳨ᰝࢆᐇ᪋ࡋ㸪HFRS 㝜ᛶࡢື≀࡜ࡍࡿࠋղ ᪥ᮏࡢື≀⏕⏘ᴗ⪅௨እ࠿ࡽᑟධࡍࡿື≀ࡣ㸪ᑟධඖࡢ㈐௵࡟࠾࠸࡚㸪᪥ᮏࡢື≀⏕⏘ᴗ⪅࡟‽ࡎࡿ SPF ື≀࡛࠶ࡾ㸪ࡲࡓ㸪ࣛࢵࢺ࡟ࡘ࠸࡚ࡣ HFRS 㝜ᛶࡢື≀࡛࠶ࡿࡇ࡜ࢆド᫂ࡍࡿ᭩㢮ࢆᥦฟࡉࢀࡓື≀࡜ࡍࡿࠋճ ື≀⏕⏘ᴗ⪅௨እ࠿ࡽ࣐࢘ࢫࠊࣛࢵࢺࢆᑟධࡍࡿሙྜࠊᅜ❧኱Ꮫື≀ᐇ㦂᪋タ༠㆟఍ࡢࠕᐇ㦂ື≀ࡢᤵཷ࡟㛵ࡍࡿ࢞࢖ࢻࣛ࢖ࣥࠖ࡟ᇶ࡙࠸ࡓ SPF ື≀࡛࡞ࡃ࡚ࡣ࡞ࡽ࡞࠸ࠋմ ࡑࡢ௚ࡢࡆࡗࡋ㢮࡟ࡘ࠸࡚ࡣ㸪ࣛࢵࢺ㸪࣐࢘ࢫ࡟‽ࡎࡿ SPF ື≀࠶ࡿ࠸ࡣእぢୖ␗ᖖࡀㄆࡵࡽࢀ
ࡎ㸪೺ᗣ≧ែࡀⰋዲ࡛㸪᳨␿ᮇ㛫୰␗ᖖࡀㄆࡵࡽࢀ࡞࠿ࡗࡓື≀࡜ࡍࡿࠋյ ࢘ࢧࢠ࡟ࡘ࠸࡚ࡣ㸪ࣛࢵࢺ㸪࣐࢘ࢫ࡟‽ࡎࡿ SPF ື≀㸦ࢡ࣮ࣜࣥ㸭࣊ࣝࢩ࣮ື≀㸧࠶ࡿ࠸ࡣእぢୖ␗ᖖࡀㄆࡵࡽࢀࡎ㸪೺ᗣ≧ែࡀⰋዲ࡛㸪᳨␿ᮇ㛫୰␗ᖖࡀㄆࡵࡽࢀ࡞࠿ࡗࡓື≀࡜ࡍࡿࠋն ࢖ࢾ㸪ࣈࢱ㸪ࢧࣝ㢮ࡣື≀⏕⏘ᴗ⪅࡟ࡼࡗ࡚⦾Ṫ࣭⏕⏘ࡉࢀࡓື≀࡜ࡋ㸪ᆅ᪉⮬἞య➼࠿ࡽㆡΏࡉࢀࡓື≀ࡣྵࡲ࡞࠸ࠋշ ࡑࡢ௚ࡢື≀࡟ࡘ࠸࡚ࡣ㸪⟶⌮ᐊ࡟ၥ࠸ྜࢃࡏࡿࠋ
4㸧≉Ṧ࡞ື≀㸪⣔⤫㸪ᖺ㱋࠶ࡿ࠸ࡣᚤ⏕≀Ꮫⓗ࡟ရ㉁ࡢ㧗࠸ື≀࡟ࡘ࠸࡚ࡣ㸪ᑟධࡲ࡛࡟࠿࡞ࡾࡢ
᪥ᩘࡸ≉ู࡞㓄៖ࢆᚲせ࡜ࡍࡿሙྜࡀ࠶ࡿࡓࡵ㸪⫋ဨ࡜༑ศ࡞ᡴྜࡏࢆ⾜ࡗࡓ࠺࠼࡛⏦ࡋ㎸ࡲࡡࡤ࡞ࡽ࡞࠸ࠋ5㸧ࣈ࣮ࣜࢲ࣮࠿ࡽ㉎ධ࡛ࡁ࡞࠸㑇ఏᏊᨵኚື≀㸪ࣔࢹࣝື≀࡞࡝≉Ṧ࡞ື≀࡟ࡘ࠸࡚ࡣ㸪⫋ဨ࡜ᡴࡕྜࡏࡓ࠺࠼࡛㸪ᐇ㦂ᐇ᪋⪅ࡀື≀ࢆ㉎ධࡋ㸪ᑟධࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
8 ື≀ࡢᦙධ࣭ᦙฟ
1㸧᪋タ࡟ᑟධࡉࢀࡓ୰ື≀㸦࢘ࢧࢠ㸪ࣈࢱࠊ࢖ࢾ➼㸧ࡣཎ๎࡜ࡋ᳨࡚␿ᚋ࡟⫋ဨࡀ㣫⫱ᐊ࡟⛣ືࡍࡿࡀ㸪࣐࢘ࢫ㸪ࣛࢵࢺࡑࡢ௚ࡢື≀ࡣ᳨␿ᚋ⫋ဨࡢᣦ♧࡟ࡼࡾᐇ㦂ᐇ᪋⪅ࡀỴࡵࡽࢀࡓ㣫⫱ᐊ࡟⛣ືࡉࡏࡿࠋ2㸧㣫⫱୰ࡢື≀࡟ࡘ࠸࡚ࡣ㣫⫱࣮࢝ࢻ࡟ᚲせ஦㡯ࢆグ㍕ࡋ཰ᐜࢣ࣮ࢪ࡟᫂♧ࡍࡿࠋ3㸧᪋タእ࡟ᣢࡕฟࡉࢀࡓື≀ࢆ෌ᗘ᪋タෆ࡟ᣢࡕ㎸ࡴࡇ࡜ࡣ⚗Ṇࡍࡿࠋ4㸧᪋タ࡟ᦙධࡋࡓ඲࡚ࡢື≀ࡢ✀㸪⣔⤫㸦ཪࡣရ✀㸧㸪ᑟධ᫬ࡢᖺ㱋㸪ᑟධඛ࡟ࡘ࠸࡚グ㘓ࡋ⟶⌮ᐊ࡟ᥦฟࡋಖᏑࡍࡿࠋࡇࡢグ㘓ࡣࠊࠕື≀ᐇ㦂᪋タ฼⏝⏦ㄳ᭩ࠖ㸦ᵝᘧ 3㸧ࢆᣢࡗ࡚⾜࠺ࠋ9 ື≀ࡢ᳨␿
1㸧ື≀ࡣᦙධ᫬࡟ᡤᐃࡢ᳨␿ࢆ⾜࠺ࠋࡲࡓ㸪ᦙධ᫬ཬࡧᐇ㦂୰࡟୙㐺࡜ุᐃࡉࢀࡓື≀࡟ࡘ࠸࡚ࡣ㸪ᐇ㦂ᐇ᪋⪅ࡣ⫋ဨ࡜༠㆟ࡢ࠺࠼ࡋ࠿ࡿ࡭ࡁฎ⨨ࢆྲྀࡽ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋᐇ㦂ᐇ᪋⪅ࡣࡑࡢ⤒⦋ࢆグ㘓ࡋ⟶⌮ᐊ࡟ᥦฟࡍࡿࠋ
2㸧ື≀ࡢ᳨␿グ㘓ࡣ⟶⌮ᐊ࡛ಖᏑࡍࡿࠋ
3㸧᳨␿୰ࡢື≀ࡣཎ๎࡜ࡋ࡚ᐇ㦂࡟౑⏝࡛ࡁ࡞࠸ࠋ
10 ື≀ࡢ㣫⫱⎔ቃ
1㸧ື≀ࡢ㣫⫱ᐊࡣ ᗘ㸰㸮㹼㸰㸴ႏ㸪‵ᗘ㸲㸮㹼㸵㸮㸣࡟ไᚚࡍࡿࠋ
2㸧↷᫂᫬㛫ࡣ༗๓ 8 ᫬࡟Ⅼⅉ㸪༗ᚋ 8 ᫬࡟ᾘⅉࡍࡿࡼ࠺ไᚚࡍࡿࠋᾘⅉ᫬㛫ᖏ࡟ධᐊࡍࡿሙྜ࡟ࡣ㸪సᴗ⏝ࡢ㟁ⅉࢆⅬࡅ㸪㏥ᐊ᫬࡟ࡣᚲࡎᾘⅉࡍࡿࠋ11 㣫⫱ჾල࣭ᶵᮦ
1㸧㏻ᖖࡢ㣫⫱࡟ᚲせ࡞ࢣ࣮ࢪ㸪⤥㣵ჾ㸪⤥Ỉࣅࣥ࠾ࡼࡧᗋᩜ➼ࡣ㸪⫋ဨࡀὙί࣭⁛⳦ࡋ࡚㸪‽ഛᐊ࡟ᖖഛࡍࡿࠋ≉࡟ᚲせ࡞≀ရ㸦౛࠼ࡤ⁛⳦ࡋࡓᐇ㦂ᶵᮦ➼㸧ࡀ࠶ࡿሙྜ࡟ࡣ㸪ணࡵ⟶⌮ᐊ࡟㐃⤡ࡍࡿࠋ
2㸧᪋タእ࡟㣫⫱⏝ჾල࠾ࡼࡧᶵᮦࡣࠊᣢࡕฟࡋ࡚ࡣ࡞ࡽ࡞࠸ࠋᣢࡕฟࡍ㝿ࡣࠊᑓ⏝ࡢᐜჾࢆ⏝ពࡍࡿࡢ࡛ࠊࡑࢀࢆ฼⏝ࡍࡿࠋᐇ㦂ᚋࡣ㏿ࡸ࠿࡟⟶⌮ᐊ࡟㐃⤡ࡋ㸪⫋ဨࡢᣦ♧࡟ࡼࡾᡤᐃ࡟఩⨨࡟㏉༷
ࡍࡿࠋ
12 㣫ᩱ
1㸧㣫ᩱࡣཎ๎࡜ࡋ࡚᪋タ୍࡛ᣓ㉎ධࡋ‽ഛᐊ࡟ᖖഛࡍࡿࠋ
2㸧≉Ṧ࡞㣫ᩱࡣᐇ㦂ᐇ᪋⪅ࡀ‽ഛࡍࡿࡇ࡜࡜ࡍࡿࠋ
13 㣫⫱⟶⌮ࡢศᢸ1㸧࣐࢘ࢫ㸪ࣛࢵࢺ㸪ࣁ࣒ࢫࢱ࣮➼ࡢᑠື≀ࡢ⤥㣵㸪⤥Ỉ㸪ࢣ࣮ࢪ஺᥮㸪ᐊෆΎᤲࡣཎ๎࡜ࡋ࡚ᐇ㦂ᐇ᪋⪅ࡀ⾜࠺ࠋࡓࡔࡋཷク㣫⫱ࢆࡋ࡚࠸ࡿࡶࡢࡣࡢࡒࡃࠋ
2㸧࢖ࢾ㸪ࢧࣝ㸪࢘ࢧࢠ➼ࡢ୰࣭኱ື≀ࡢ⤥㣵㸪⤥Ỉ㸪ࢣ࣮ࢪ஺᥮㸪㣫⫱Ჴ㸪ᐊෆΎᤲࡣཎ๎࡜ࡋ࡚⫋ဨࡀ⾜࠺ࠋ3㸧ឤᰁᐇ㦂࠶ࡿ࠸ࡣ≉Ṧ࡞ᐇ㦂୰ࡢື≀ࡢ㣫⫱⟶⌮ࡣᐇ㦂ᐇ᪋⪅࡛⾜࠺ࠋ
14 㣫⫱⟶⌮ࡢ᪉ἲ1㸧࣐࢘ࢫ㸪ࣛࢵࢺ➼ࡢᑠື≀ࡢὙί῭ࡳ⁛⳦ࢣ࣮ࢪ㢮㸪⤥Ỉࣅࣥ㸪㣫ᩱ➼ࡣ‽ഛᐊ࡟ᖖഛࡍࡿࠋ
2㸧ᗋᩜ౑⏝ࡢࢣ࣮ࢪࡣ㐌 1 ᅇ㸪Ὑί῭ࡳ⁛⳦ࢣ࣮ࢪ࡟஺᥮ࡍࡿࠋ
3㸧⤥Ỉࣅࣥ࡟ࡼࡿឤᰁࢆ㜵Ṇࡍࡿࡓࡵ㸪୍᪦౑⏝ࡋࡓ⤥Ỉࣅࣥࢆ௚ࡢࢣ࣮ࢪ࡟౑⏝ࡋ࡚ࡣ࠸ࡅ࡞࠸ࠋ
4㸧౑⏝ࡋࡓ㣫⫱ჾල࠾ࡼࡧᶵᮦ㢮ࡣᐇ㦂⪅ࡀᡤᐃࡢ఩⨨࡟㐠ᦙࡍࡿࠋ
15 㣫⫱⤒㈝➼
ື≀ูࡢ㣫⫱⤒㈝㸦ᗋᩜ௦㸪⟶⌮㈝㸪✵ㄪ㈝㸪ჾලᦆᩱ➼ࢆྵࡴࠋ㸧ࡣ⾲ 2 ࡢ࡜࠾ࡾ࡜ࡍࡿࠋ
⾲ 2 㣫⫱⤒㈝
ື≀✀ู㣫⫱⤒㈝㸦෇㸭ࢣ࣮ࢪ࣭5 ༉࣭᪥㸧࣐࢘ࢫ 4 㝵28

࣐࢘ࢫ 5 㝵 SPF

40㸦෇㸭ࢣ࣮ࢪ࣭4 ༉࣭᪥㸧ࣛࢵࢺ 4 㝵75

ࣛࢵࢺ 5 㝵 SPF

86㸦෇㸭ࢣ࣮ࢪ࣭5 ༉࣭᪥㸧ཷク㣫⫱ ࣐࢘ࢫ 4 㝵78

ཷク㣫⫱ ࣐࢘ࢫ 5 㝵 SPF

90㸦෇㸭ࢣ࣮ࢪ࣭4 ༉࣭᪥㸧ཷク㣫⫱ ࣛࢵࢺ 4 㝵125ཷク㣫⫱ ࣛࢵࢺ 5 㝵 SPF

136
㸦෇㸭ࢣ࣮ࢪ࣭1 ༉࣭᪥㸧

࢘ࢧࢠ

130

࢖ࢾ

255

ࣈࢱ

255
㸦෇㸭1 ࢔࢖ࢯ࣮ࣞࢩࣙࣥ BOX࣭᪥㸧

P2㸦࢔࢖ࢯ࣮ࣞࢩࣙࣥ BOX㸧

130

P3㸦࢔࢖ࢯ࣮ࣞࢩࣙࣥ BOX㸧

195

2㸧ࣅࢽ࣮ࣝ࢔࢖ࢯ࣮ࣞࢱࢆ౑⏝ࡍࡿሙྜࡢ౑⏝⤒㈝ࡣ㸪ࣇ࢕ࣝࢱ࣮஺᥮㈝ཬࡧ㟁Ẽᩱ࡜ࡋ࡚㸪100 ෇㸭ྎ࣭᪥࡜ࡍࡿࠋ
3㸧㣫⫱ᐊࡢ୍㒊࠶ࡿ࠸ࡣ๓ᐊࢆᐇ㦂ᐊ࡜ࡋ࡚౑⏝ࡍࡿሙྜࡢ౑⏝⤒㈝ࡣ㸪✵ㄪ㈝࡜ࡋ࡚ᑓ᭷ࡍࡿ㠃✚࡟ࡼࡾ⟬ฟࡍࡿࠋ1500 ෇㸭ᖹ⡿࣭᭶
4㸧ື≀ࡢṚయฎ⌮࡟ಀࢃࡿ⤒㈝ࡣ⾲ 3 ࡟ᐃࡵࡿࠋ
⾲ 3 Ṛయฎ⌮⤒㈝㸦ᐇ㈝࡜࡞ࡾࡲࡍ㸧ᖹᡂ 31࣭௧࿴ඖᖺᗘᩱ㔠✀㢮᝿ᐃ㔜㔞㸦g㸧

༢౯㸭༉

࣐࢘ࢫ

40

26

ࣛࢵࢺ

400

255

ࣔࣝࣔࢵࢺ

500

319

ࢫࢼࢿࢬ࣑

60

38

ࣁ࣒ࢫࢱ࣮

150

96

࢘ࢧࢠ

2,000

1,600

࢖ࢾ

ᐇ㈝

ࣈࢱ

ᐇ㈝

ᒈయฎ⌮⤒㈝ࡣ 637.2 ෇㸭kg㸦ᖺᗘ࡟ࡼࡾኚ᭦ࡢྍ⬟ᛶ᭷ࡾ㸧࡛ィ⟬ࠋࡓࡔࡋࠊࡼࡃ౑ࢃ
ࢀࡿ㱎ṑ㢮࡟㛵ࡋ࡚ࡣࠊಶయࡈ࡜࡟య㔜ࢆ ᐃࡍࡿࡢࡀᅔ㞴࡞ࡢ࡛ࠊ᝿ᐃ㔜㔞࡟ࡼࡾỴࡵࡓᩱ㔠୍࡛ᚊㄢ㔠ࠋ5㸧ୖグࡢ⤒㈝ࡣ㸪ཷ┈⪅㈇ᢸศ࡜ࡋ࡚ཷ┈⪅࡟ࡣẖ᭶ሗ࿌ࡋ㸪ண⟬ࡣ 3 ࣨ᭶ࡈ࡜࡟㟁⟬ฎ⌮ࡋཷ┈⪅ㅮᗙ➼࠿ࡽ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ண⟬࡟᣺᭰࠼ࡿࠋ
16 ᐇ㦂᧯స
1㸧ᐇ㦂ᐇ᪋⪅ࡣ㸪ື≀ᐇ㦂ࢆ⾜࠺㝿࡟ࡣ㸪⾲ 4 ࡟♧ࡍࡼ࠺࡞Ⅼ࡟㓄៖ࡋ㸪ᐇ㦂ື≀࡟↓⏝ࡢⱞ③ࢆ୚࠼࡞࠸ࡼ࠺㓄៖ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ⾲ 4㸬೔ᇙᇶ‽࡟ࡼࡿ་Ꮫ⏕≀Ꮫᐇ㦂ἲ࡟㛵ࡍࡿศ㢮㸦Laboratory Animal Science ∧㸧࢝ࢸࢦ࣮ࣜฎ⨨౛࠾ࡼࡧᑐฎἲ

࢝ࢸࢦࣜ A⏕໬Ꮫⓗࠊ᳜≀Ꮫⓗ◊✲ࠊ⣽⳦Ꮫⓗ◊✲ࠊᚤ⏕≀Ꮫⓗ◊✲ࠊ↓⬨᳝ື≀ࢆ⏝࠸ࡓ◊✲ࠊ⤌⧊ᇵ㣴ࠊ๗᳨࡟ࡼࡾᚓࡽࢀࡓ⤌⧊ࢆ⏝࠸ࡓ◊✲ࠊᒕሙ࠿ࡽ

⏕≀ಶయࢆ⏝࠸࡞࠸ᐇ㦂࠶ࡿ࠸ࡣ᳜≀ࠊ⣽⳦ࠊᚓࡽࢀࡓ⤌⧊ࢆ⏝࠸ࡓ◊✲ࠋⓎ⫱㭜༸ࢆ⏝࠸ࡓ◊ཎ⹸ࠊཪࡣ↓⬨᳝ື≀ࢆ⏝࠸ࡓᐇ㦂✲ࠋ↓⬨᳝ື≀ࡶ⚄⤒⣔ࢆᣢࡗ࡚࠾ࡾࠊ่⃭࡟཯ᛂࡍࡿࠋᚑࡗ࡚↓⬨᳝ື≀ࡶே㐨ⓗ࡟ᢅࢃࢀ࡞ࡅࢀࡤ
࡞ࡽ࡞࠸ࠋ࢝ࢸࢦࣜ Bᐇ㦂ࡢ┠ⓗࡢࡓࡵ࡟ື≀ࢆࡘ࠿ࢇ࡛ಖᐃࡍࡿࡇ
࡜ࠋ࠶ࡲࡾ᭷ᐖ࡛࡞࠸≀㉁ࢆὀᑕࡋࡓࡾࠊ࠶ࡿ࠸
ࡣ᥇⾑ࡋࡓࡾࡍࡿࡼ࠺࡞⡆༢࡞ฎ⨨ࠋື≀ࡢయࢆ⬨᳝ື≀ࢆ⏝࠸ࡓ◊✲࡛ࠊື≀࡟ᑐࡋ࡚࡯࡜ࢇ ᳨ᰝࡍࡿࡇ࡜ࠋ῝㯞㓉࡟ࡼࡾព㆑ࢆᅇ᚟ࡍࡿࡇ࡜
࡝ࠊ࠶ࡿ࠸ࡣࡲࡗࡓࡃ୙ᛌឤࢆ୚࠼࡞࠸࡜ᛮࢃ ࡢ࡞࠸ື≀ࢆ⏝࠸ࡓᐇ㦂ࠋ▷᫬㛫㸦㸰ࠥ㸱᫬㛫㸧ࢀࡿᐇ㦂᧯స

ࡢ⤯㣗⤯Ỉࠋᛴ㏿࡟ព㆑ࢆᾘኻࡉࡏࡿᶆ‽ⓗ࡞ᏳᴦṚἲࠋ౛࠼ࡤࠊ኱㔞ࡢ㯞㓉⸆ࡢᢞ୚ࡸ㍍ࡃ㯞㓉ࢆ࠿ࡅࡿ࡞࡝ࡋ࡚㙠㟼ࡉࡏࡓື≀ࢆ᩿㤳ࡍࡿࡇ࡜࡞࡝ࠋ࢝ࢸࢦࣜ C㯞㓉ୗ࡛⾑⟶ࢆ㟢ฟࡉࡏࠊ࢝ࢸ࣮ࢸࣝࢆ㛗᫬㛫ᤄධࡍࡿࡇ࡜ࠋ⾜ືᏛⓗᐇ㦂࡟࠾࠸࡚ࠊព㆑࠶ࡿື
≀࡟ᑐࡋ࡚▷᫬㛫ࢫࢺࣞࢫࢆక࠺ಖᐃ㸦ᣊ᮰㸧ࢆ⬨᳝ື≀ࢆ⏝࠸ࡓᐇ㦂࡛ࠊື≀࡟ᑐࡋ࡚㍍ᚤ࡞ ⾜࠺ࡇ࡜ࠋࣇࣟ࢖ࣥࢺࡢ࢔ࢪࣗࣂࣥࢺࢆ⏝࠸ࡓචࢫࢺࣞࢫ࠶ࡿ࠸ࡣ③ࡳ㸦▷᫬㛫ᣢ⥆ࡍࡿ③ࡳ㸧 ␿ࠋⱞ③ࢆక࠺ࡀࠊࡑࢀ࠿ࡽ㏨ࢀࡽࢀࡿ่⃭ࠋ㯞ࢆక࠺ᐇ㦂ࠋ

㓉ୗ࡟࠾ࡅࡿእ⛉ⓗฎ⨨࡛ࠊฎ⨨ᚋࡶከᑡࡢ୙ᛌ
ឤࢆక࠺ࡶࡢࠋ
࢝ࢸࢦࣜ C ࡢฎ⨨ࡣࠊࢫࢺࣞࢫࡸ③ࡳࡢ⛬ᗘࠊᣢ⥆᫬㛫࡟ࡼࡗ࡚࠸ࢁ࠸ࢁ࡞㓄៖࠿ᚲせ࡟࡞ࡿࠋ࢝ࢸࢦࣜ D⾜ືᏛⓗᐇ㦂࡟࠾࠸࡚ᨾព࡟ࢫࢺࣞࢫࢆຍ࠼ࡿ
ࡇ࡜ࠋ㯞㓉ୗ࡟࠾ࡅࡿእ⛉ⓗฎ⨨࡛ࠊฎ⨨ᚋ࡟ⴭࡋ࠸୙ᛌឤࢆక࠺ࡶࡢࠋⱞ③ࢆక࠺ゎ๗Ꮫⓗ⬨᳝ື≀ࢆ⏝࠸ࡓᐇ㦂࡛ࠊ㑊ࡅࡿࡇ࡜ࡢ࡛ࡁ࡞ ࠶ࡿ࠸ࡣ⏕⌮Ꮫⓗฎ⨨ࠋⱞ③ࢆక࠺่⃭ࢆ୚࠼ࡿᐇ㦂࡛ࠊື≀ࡀࡑࡢ่⃭࠿ࡽ㏨ࢀࡽࢀ࡞࠸ሙ

࠸㔜ᗘࡢࢫࢺࣞࢫࡸ③ࡳࢆక࠺ᐇ㦂ࠋྜࠋ㛗᫬㛫㸦ᩘ᫬㛫࠶ࡿ࠸ࡣࡑࢀ௨ୖ㸧࡟ࢃࡓࡗ࡚ື≀ࡢ㌟యࢆಖᐃ㸦ᣊ᮰㸧ࡍࡿࡇ࡜ࠋᨷᧁⓗ࡞⾜ືࢆ࡜ࡽࡏࠊ⮬ศ⮬㌟࠶ࡿ࠸ࡣྠ✀௚ಶయࢆᦆയࡉࡏࡿࡇ࡜ࠋ㯞㓉⸆ࢆ౑⏝ࡋ࡞࠸࡛③ࡳࢆ୚࠼ࡿࡇ࡜ࠋ౛࠼ࡤࠊẘᛶヨ㦂࡟࠾࠸࡚ࠊື≀ࡀ⪏࠼ࡿࡇ࡜ࡢ࡛ࡁࡿ᭱኱ࡢ③ࡳ࡟㏆࠸③ࡳࢆ୚࠼ࡿࡇ࡜ࠋࡘࡲࡾື≀ࡀ⃭ࡋ࠸ⱞ᝖ࡢ⾲᝟ࢆ♧ࡍሙྜࠋᨺᑕ⥺㞀ᐖࢆࡦࡁ࠾ࡇࡍࡇ࡜ࠋ࠶ࡿ✀ࡢὀᑕࠊࢫࢺࣞࢫࡸࢩࣙࢵࢡࡢ◊✲࡞࡝ࠋ࢝ࢸࢦࣜ D ࡟ᒓࡍࡿᐇ㦂ࢆ⾜࠺ሙྜ࡟ࡣࠊ◊✲⪅ࡣࠊື≀࡟ᑐࡍࡿⱞ③ࢆ᭱ᑠ㝈ࡢࡶࡢ࡟ࡍࡿ
ࡓࡵ࡟ࠊ࠶ࡿ࠸ࡣⱞ③ࢆ᤼㝖ࡍࡿࡓࡵ࡟ࠊูࡢ
᪉ἲࡀ࡞࠸࠿᳨ウࡍࡿ㈐௵ࡀ࠶ࡿࠋ
࢝ࢸࢦࣜ Eᡭ⾡ࡍࡿ㝿࡟㯞㓉⸆ࢆ౑ࢃࡎࠊ༢࡟ື≀ࢆື࠿࡞ࡃࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚➽ᘱ⦆⸆࠶ࡿ࠸ࡣ㯞⑷ᛶ⸆๣ࠊ౛࠼ࡤࢧࢡࢩࢽࣝࢥࣜࣥ࠶ࡿ࠸ࡣࡑࡢ௚

㯞㓉ࡋ࡚࠸࡞࠸ព㆑ࡢ࠶ࡿື≀ࢆ⏝࠸࡚ࠊື≀ ࡢࢡ࣮ࣛࣞᵝస⏝ࢆᣢࡘ⸆๣ࢆ౑࠺ࡇ࡜ࠋ㯞㓉ࡋࡀ⪏࠼ࡿࡇ࡜ࡢ࡛ࡁࡿ᭱኱ࡢ③ࡳࠊ࠶ࡿ࠸ࡣࡑ ࡚࠸࡞࠸ື≀࡟㔜ᗘࡢⅆയࡸእയࢆࡦࡁ࠾ࡇࡍ
ࡇ࡜ࠋ⢭⚄⑓ࡢࡼ࠺࡞⾜ືࢆ࠾ࡇࡉࡏࡿࡇ࡜ࠋᐙ

ࢀ௨ୖࡢ③ࡳࢆ୚࠼ࡿࡼ࠺࡞ฎ⨨ࠋᗞ⏝ࡢ㟁Ꮚࣞࣥࢪ࠶ࡿ࠸ࡣࢫࢺࣜ࢟ࢽ࣮ࢿࢆ⏝࠸࡚ẅࡍࡇ࡜ࠋ㑊ࡅࡿࡇ࡜ࡢ࡛ࡁ࡞࠸㔜ᗘࡢࢫࢺࣞࢫࢆ୚࠼ࡿࡇ࡜ࠋࢫࢺࣞࢫࢆ୚࠼࡚ẅࡍࡇ࡜ࠋ࢝ࢸࢦࣜ E ࡢᐇ㦂ࡣࠊࡑࢀ࡟ࡼࡗ࡚ᚓࡽࢀࡿ⤖ᯝࡀ㔜せ࡞ࡶࡢ࡛࠶ࡗ࡚ࡶࠊỴࡋ࡚⾜ࡗ࡚ࡣ࡞ࡽ࡞
࠸ࠋ࢝ࢸࢦࣜ E ࡟ᒓࡍࡿ኱㒊ศࡢฎ⨨ࡣࠊᅜࡢἲᚊ࡟
ࡼࡗ࡚⚗Ṇࡉࢀ࡚࠾ࡾࠊࡋࡓࡀࡗ࡚ࠊࡇࢀࢆ⾜ࡗࡓሙྜࡣࠊᅜ࠿ࡽࡢ◊✲㈝ࡣἐ཰ࡉࢀࠊࡑࡋ࡚㸦ࡲࡓࡣ㸧ࡑࡢ◊✲᪋タࡢ㎰ົ┬࡬ࡢⓏ㘓ࡣྲྀࡾᾘࡉ
ࢀࡿࡇ࡜ࡀ࠶ࡿ㸬
Laboratory Animal Science. Special Issue : 11-13, 1987 ࡟ࡼࡿ
2㸧ᐇ㦂ᐇ᪋⪅ࡣ㸪ື≀ᐇ㦂ࢆ⤊஢ࡋ㸪ཪࡣ୰᩿ࡋࡓᐇ㦂ື≀ࢆฎศࡍࡿሙྜ࡟ࡣ㸪⾲ 5 ࡟♧ࡍࡼ࠺࡞᪉ἲ࡟ࡼࡾ㸪ᐇ㦂ື≀࡟࡛ࡁࡿ㝈ࡾⱞ③ࢆ୚࠼࡞࠸᪉ἲ࡛⾜࠸㸪ࡑࡢṚࢆ☜ㄆࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
⾲ 5 ື≀࡟ⱞ③ࢆ୚࠼࡞࠸᪉ἲ㸦ᏳᴦṚࡢ᪉ἲ㸧
ື≀✀
࣐࢘ࢫ
ࣛࢵࢺ
ࣔࣝࣔࢵࢺ
ᑠᆺ㱎ṑ㢮
࢘ࢧࢠ
ࢿࢥ
࢖ࢾ
ࢧࣝ㢮
ࢺࣜ㢮
ᐙ␆㢮
ୗ➼⬨᳝ື≀↓⬨᳝ື≀ࣂࣝࣅࢶࣞ࢖ࢺ
㟼⬦ὀᑕ
㸩 *1
㸩 *1
㸩 *2
㸩 *1
㸩 *2
+
+
+
㸩 *2
+

Ⅳ㓟࢞ࢫ྾ධ

㢕᳝⬺⮻

᩿㤳

+
+
+
+
+
+
+
+
+
+

+
+

+
+

+

+

+
+

ト㸧*1㸸⭡⭍ෆ࡛ࡶࡼ࠸ࠋ*2㸸ᚰ⮚ෆ࡛ࡶࡼ࠸ࠋ



↻Ἓ

+
+

17 Ṛయࡢฎ⌮1㸧ᐇ㦂ᐇ᪋⪅ࡣ㸪ື≀ᐇ㦂࡟ࡼࡾ㛤⬚࣭㛤⭡ࡋࡓᑠື≀௨እࡢᐇ㦂ື≀ࡣ㸪⦭ྜ࣭ᩚ᚟ࡍࡿࠋ
2㸧ᐇ㦂ᐇ᪋⪅ࡣ㸪ᐇ㦂ື≀ࡢṚయࢆྛ㝵࡟ᖖഛࡋࡓࣅࢽ࣮ࣝ⿄➼࡟ධࢀ࡚㸪ᣦᐃࡉࢀࡓ㈓ⶶᡤࡲ࡛
⛣ືࡋ㸪ಖᏑࡍࡿࠋ
3㸧ᐇ㦂ື≀ࡢಖᏑᒈయࡣࠊᒈయฎศᴗ⪅࡟౫クࡍࡿࠋ18 ở≀࣭ሻᇕࡢฎ⌮1㸧ᐇ㦂ᐇ᪋⪅ࡣ㸪ᐇ㦂࣭ฎ⨨➼࡟ࡼࡗ࡚⏕ࡌࡓở≀࣭ሻᇕࢆฎ⨨ᐊ࡟タ⨨ࡉࢀࡓᡤᐃࡢᐜჾ࡟ᗫᲠ
༊ศ࡟ᚑ࠸ฎ⌮ࡍࡿࠋ
2㸧ὀᑕ㔪࠾ࡼࡧ࢞ࣛࢫჾල㢮ࡢฎ⌮ࡣ㸪஦ᨾ㜵Ṇࡢࡓࡵ୍⯡ሻᇕ࡟⤯ᑐ࡟ΰධࡋ࡚ࡣ࠸ࡅ࡞࠸ࠋ
3㸧ᡤᐃࡢᐜჾෆ࡟ฎ⌮ࡉࢀࡓở≀࣭ሻᇕࡣ⫋ဨࡀ᭱⤊ฎ⌮ࡍࡿࠋ
19 ᐇ㦂ᐊ➼㸦ᐇ㦂ᐊ㸪๓ᐊ㸪ᡭ⾡ᐊ㸧ࡢ౑⏝1㸧ᐇ㦂ᐊ➼ࡢ౑⏝ࢆᕼᮃࡍࡿ࡜ࡁࡣ㸪᭶ᮎࡲ࡛࡟⩣᭶ࡢ౑⏝ணᐃࢆࠕື≀ᐇ㦂᪋タᐇ㦂ᐊ౑⏝㢪ࠖ㸦ᵝᘧ 4-1ࠊ4-2㸧࡟グධࡢ࠺࠼⟶⌮ᐊ࡟⏦ࡋ㎸ࡴࠋ
2㸧ᐇ㦂ᐇ᪋⪅ࡣ㸪ᐇ㦂ᐊ➼࡛ࡢ‽ഛ㸪ᐇ㦂⿵ຓࢆ⾜࠸㸪⫋ဨࡢᣦᑟ࡟ࡼࡾΎᤲ㸪ᩚ⌮ᩚ㡻ࢆ⾜࠺ࠋ3㸧ᡭ⾡ჾල➼ࡢ⁛⳦ࢆᚲせ࡜ࡍࡿᐇ㦂ᐇ᪋⪅ࡣ㸪⟶⌮ᐊ࡟㐃⤡ࡋ㧗ᅽ⵨Ẽ࣭࢞ࢫ⁛⳦ࡢ࠸ࡎࢀ࠿ࢆ
グධࡋࡓ⏝⣬࡜࡜ࡶ࡟ᡭ⾡ჾල➼ࢆ౑⏝ணᐃࡢ 2 ᪥๓ࡲ࡛࡟ᡤᐃࡢሙᡤ࡟⨨ࡃࠋ⫋ဨࡣ㸪⁛⳦ᚋࡢᡭ⾡ჾල➼ࢆ౑⏝ணᐃ᪥ࡲ࡛࡟ᡤᐃࡢሙᡤ࡟‽ഛࡍࡿࠋ
4㸧ᑠື≀ࡢฎ⨨㸦᥇⾑࣭እ⛉ᡭ⾡࣭ゎ๗➼㸧ࡣཎ๎࡜ࡋ࡚ᐇ㦂ᐊ࡛⾜࠺ࡶࡢ࡜ࡍࡿࠋ
5㸧ᐇ㦂ᐊ➼ࡢ౑⏝⤒㈝࡞ࡽࡧ࡟㈚ࡋฟࡋ⤒㈝ࡣ⾲ 6 ࡟ᐃࡵࡿࠋ
⾲6ᖹ⡿༢౯ 1,650 ෇㸭᭶࡛ィ⟬ࠋ

㸲Fࠥ㸱F ᐇ㦂ᐊ㸦㈚ࡋฟࡋ㸧㸦32 ᖹ⡿㸸330ࠊ405ࠊ406㸪407㸪408㸪409㸧 ୍㒊ᒇ 32 ᖹ⡿࠶ࡿࡢ࡛ࠊ52,800 ෇㸭᭶㸦16 ᖹ⡿㸸402㸧㸲F ᐇ㦂ᐊᮘ㸦㈚ࡋฟࡋ㸧

11,000 ෇ࠥ12,000 ෇㸭᭶࣭㸯ᮘ㸱F ᡭ⾡ᐊ

2,200 ෇㸭୍᪥୍࣭㒊ᒇ

20 ᐇ㦂ᐊ➼㸦ᐇ㦂ᐊ㸪๓ᐊ㸪ᡭ⾡ᐊ㸧࡬ࡢᶵჾ㢮ࡢᣢࡕ㎸ࡳ
1㸧ᐇ㦂ᐇ᪋⪅ࡀᐇ㦂ᐊ➼࡬ᶵჾ㢮ࡣᚲせ᭱ᑠ㝈ࡢࡶࡢ࡜ࡍࡿࠋ
2㸧ᐇ㦂ᐇ᪋⪅ࡣ㸪ᣢࡕ㎸ࡴ࣭ჾල㢮ࡣഛ࠼௜ࡅࡢᾘẘ⏝࢔ࣝࢥ࣮ࣝ㸦ᾘẘ⸆㸧࡛ᄇ㟝ᾘẘࡍࡿࠋ
3㸧ᐇ㦂ᐊ➼࡬ࡢᶵჾ㢮ࡢᣢࡕ㎸ࡳ㸪⥔ᣢ⟶⌮㸪ᦙฟࡣᐇ㦂ᐇ᪋⪅ࡢ㈐௵࡟࠾࠸࡚⾜࠺ࠋ࡞࠾㸪ᦙฟࡣື≀ᐇ㦂⤊஢ᚋ㏿ࡸ࠿࡟⾜࠺ࠋ4㸧ᡭ⾡ᐊ➼ࡢ་⒪㓄⟶࡟᥋⥆ࡍࡿ࢞ࢫ࣎ࣥ࣋ࡢ⟶⌮ࡣ⫋ဨࡀ⾜࠺ࠋ21 ᐇ㦂ჾල࣭ᶵᮦࡢ㈚୚
1㸧ື≀ᐇ㦂࡟౑⏝ࡍࡿჾල㸪ᶵᮦࡢ࠺ࡕ᪋タࡀᡤ᭷ࡍࡿࡶࡢࡣ㈚୚ࡍࡿࠋ
2㸧᪋タࡀᡤ᭷ࡋ࡞࠸≀ရࡸ≉Ṧ࡞ჾල㸪ᶵᮦ㢮ࡣᐇ㦂ᐇ᪋⪅ࡀ‽ഛࡍࡿࠋ

22 ᫬㛫እࡢ౑⏝1㸧᫬㛫እ࡜ࡣ㸪ᖹ᪥ࡢ༗๓㸷᫬࠿ࡽ㸯㸵᫬ࢆ㝖ࡃ᫬㛫㸪ᅵ᭙᪥㸪᪥᭙᪥㸪ࠕᅜẸࡢ⚃᪥࡟㛵ࡍࡿἲᚊ࡟つᐃࡍࡿఇ᪥࠾ࡼࡧ㸯㸰᭶㸰㸶᪥࠿ࡽ⩣ᖺ㸯᭶㸲᪥ࡲ࡛࡜ࡍࡿࠋ
2㸧᪋タࡢฟධࡾࡣධ㏥㤋ࢩࢫࢸ࣒࡟ࡼࡾ⟶⌮ࡉࢀ࡚࠸ࡿࡓࡵ㸪Ⓩ㘓⪅௨እࡢ౑⏝ࡣ࡛ࡁ࡞࠸ࠋ᪋タࡢฟධࡾࡣ㸪ᐇ㦂ᐇ᪋⪅ࡢ⏕࿨⛉ᏛᲷ฼⏝⪅࣮࢝ࢻ࡟ࡼࡗ࡚᫬㛫እ࡟౑⏝ࡍࡿ࡜ࡁࡣ㸪౑⏝ᚋࡢᐊෆࡢᾘⅉ㸪ⅆẼࡢጞᮎࡢ☜ㄆࢆ༑ศ࡟⾜࠺ࠋ23 ஦ᨾⓎ⏕᫬ࡢᑐᛂ୙៖ࡢ஦ᨾࡀⓎ⏕ࡋࡓሙྜࡣ㸪ࡓࡔࡕ࡟⟶⌮ᐊཬࡧ㛵ಀ⪅࡟㐃⤡ࡋ㐺ษ࡞ᥐ⨨ࢆㅮࡌࡿࠋᐇ㦂ᐇ᪋⪅ࡣ஦ᚋ࡟ࡑࡢሗ࿌᭩ࢆసᡂࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ᫬㛫እࡢ⥭ᛴ㐃⤡ඛࡣ⾲㸵ࡢ࡜࠾ࡾ࡛࠶ࡿࠋ
⾲7⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ື≀ᐇ㦂ศ㔝⟶⌮ᐊᖹᖖ᫬ࠊ⥭ᛴ᫬୰ኸ┘ど㸦24 ᫬㛫㸧᫬㛫እࠊ⥭ᛴ᫬
㜵⅏ࢭࣥࢱ࣮㸦24 ᫬㛫㸧ෆ⥺ 6608058-230-6608
ෆ⥺ 7026058-230-7026
ෆ⥺ 7098058-230-7098

24 ᪋タෆ㟁ヰཬࡧ࿧ࡧฟࡋ᪉ἲ
1㸧᪋タෆࡢ㟁ヰࡣ⾲ 8 ࡢ࡜࠾ࡾ࡛࠶ࡿࠋ
㸦ࢲ࢖ࣖࣝ࢖ࣥ㸧௨እࡢ㟁ヰࡣࠊᏛእ࡬ࡘ࡞ࡀࡽ࡞࠸ࠋ
⾲8་Ꮫ㒊⏕࿨⛉ᏛᲷ2㝵་Ꮫ㒊⏕࿨⛉ᏛᲷ3㝵་Ꮫ㒊⏕࿨⛉ᏛᲷ4㝵་Ꮫ㒊⏕࿨⛉ᏛᲷ5㝵⟶⌮ᐊ㸦ࢲ࢖ࣖࣝ࢖ࣥ㸧ᩍဨᐊ㸦ࢲ࢖ࣖࣝ࢖ࣥ㸧ࢭ࣑ࢼ࣮ᐊᐇ 㦂 ᐊ 31㸦 ඹ ㏻ ᐇ 㦂 ᐊ 㸧
P2 ᐇ 㦂 ᐊὙί⁛⳦ᐊ
P3 ᐇ 㦂 ᐊᡭ⾡‽ഛᐊᐇ 㦂 ᐊ 41ᐇ 㦂 ᐊ 43㸦 ㈚ ฟ ᐇ 㦂 ᐊ 㸧㣫ᩱ㈓ⶶᐊ㸦Ὑί‽ഛᐊ㸧ᐇ 㦂 ᐊ 44㸦 ᐇ 㦂 ᮘ ㈚ ฟ ᐊ 㸧ᐇ 㦂 ᐊ 45ᐇ 㦂 ᐊ 46㸦 ඹ ㏻ ᐇ 㦂 ᐊ 㸧ᐇ 㦂 ᐊ 47㸦 ᐇ 㦂 ᮘ ㈚ ฟ ᐊ 㸧ᐇ 㦂 ᐊ 51㸦 ࢭ ࣑ SPF ඹ ㏻ ᐇ 㦂 ᐊ 㸧
SPF 㣫 ᩱ ᐊ
SPF ᐇ 㦂 ᐊ 㸦 ඹ ㏻ ᐇ 㦂 ᐊ 㸧Ὑί⁛⳦ᐊ㸦ࢲ࣮ࢸ࢕ࢧ࢖ࢻ㸧Ὑί⁛⳦ᐊ㸦ࢡ࣮ࣜࣥࢧ࢖ࢻ㸧



6608
6609
8909
8913
8916
8917
8918
8922
8924
8927
8928
8929
8930
8931
8932
8933
8934
8935
8936
8935

25 ౑⏝ࡢไ㝈ཪࡣ⚗Ṇ౑⏝ᚰᚓࢆ㑂Ᏺࡏࡎ㸪௚࡟ⴭࡋࡃ㏞ᝨࢆཬࡰࡋࡓሙྜࡸᒱ㜧኱Ꮫື≀ᐇ㦂ྲྀᢅつ⛬࠿ࡽ㐓⬺ࡍࡿࡼ࠺࡞ᐇ㦂ࢆ⾜ࡗࡓሙྜ࡟ࡣ㸪᪋タ౑⏝ࡢไ㝈ཪࡣ⚗Ṇࡢᥐ⨨ࢆㅮࡌࡿࡇ࡜ࡀ࠶ࡿࠋ
26 ື≀ᐇ㦂ᑓ㛛㒊఍⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㐠Ⴀጤဨ఍つ๎➨㸶᮲ࡢつᐃ࡟ࡼࡾ㸪᪋タࡢ㐠Ⴀ࡟ಀࡿ≉ᐃ஦㡯ࢆᑂ㆟ࡍࡿࡓࡵ㸪ື≀ᐇ㦂᪋タᑓ㛛㒊఍ࢆ⨨ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ



3-3. ᅜ❧኱Ꮫἲேᒱ㜧኱Ꮫື≀ᐇ㦂ྲྀᢅつ⛬ᖹᡂ㸰㸮ᖺ㸱᭶㸯㸯᪥ つ⛬➨㸰㸶ྕ
㸦㊃᪨➼㸧
➨ 1 ᮲ ᮾᾏᅜ❧኱Ꮫᶵᵓື≀ᐇ㦂ྲྀᢅつ⛬㸦௧࿴ 2 ᖺᗘᶵᵓつ⛬➨ 74 ྕ㸧➨ 2 ᮲➨ 2 㡯ࡢつᐃ࡟ᇶ࡙ࡁ㸪ᒱ㜧኱Ꮫ㸦௨ୗࠕᮏᏛࠖ࡜࠸࠺ࠋ㸧࡟࠾ࡅࡿື≀ᐇ㦂➼ࡢ㐺ṇ࠿ࡘᏳ඲࡞ᐇ᪋࡟㛵ࡋᚲせ࡞஦㡯ࡣࡇࡢつ⛬ࡢᐃࡵࡿ࡜ࡇࢁ࡟ࡼࡿࠋ
㸦ᇶᮏཎ๎㸧
➨ 1 ᮲ࡢ 2 ື≀ᐇ㦂➼ࢆ⾜࠺⪅ࡣ㸪ື≀ࡢឡㆤཬࡧ⟶⌮࡟㛵ࡍࡿἲᚊ㸦᫛࿴ 48 ᖺἲᚊ➨ 105 ྕࠋ௨ୗࠕື≀ឡㆤἲࠖ࡜࠸࠺ࠋ㸧ཬࡧᐇ㦂ື≀ࡢ㣫㣴ཬࡧಖ⟶୪ࡧ࡟ⱞ③ࡢ㍍ῶ࡟㛵ࡍࡿᇶ‽㸦ᖹᡂ 18ᖺ⎔ቃ┬࿌♧➨ 88 ྕࠋ௨ୗࠕ㣫㣴ಖ⟶ᇶ‽ࠖ࡜࠸࠺ࠋ㸧࡟๎ࡋ㸪ື≀ᐇ㦂➼ࡢཎ๎࡛࠶ࡿ௦᭰ἲ
ࡢ฼⏝㸦⛉Ꮫୖࡢ฼⏝ࡢ┠ⓗࢆ㐩ࡍࡿࡇ࡜ࡀ࡛ࡁࡿ⠊ᅖ࡟࠾࠸࡚㸪࡛ࡁࡿ㝈ࡾື≀ࢆ౪ࡍࡿ᪉ἲ࡟
௦ࢃࡾᚓࡿࡶࡢࢆ฼⏝ࡍࡿࡇ࡜ࢆ࠸࠺ࠋ㸧㸪౑⏝ᩘࡢ๐ῶ㸦⛉Ꮫୖࡢ฼⏝ࡢ┠ⓗࢆ㐩ࡍࡿࡇ࡜ࡀ࡛
ࡁࡿ⠊ᅖ࡟࠾࠸࡚㸪࡛ࡁࡿ㝈ࡾࡑࡢ฼⏝࡟౪ࡉࢀࡿື≀ࡢᩘࢆᑡ࡞ࡃࡍࡿࡇ࡜➼࡟ࡼࡾᐇ㦂ື≀ࢆ㐺ษ࡟฼⏝ࡍࡿࡇ࡜࡟㓄៖ࡍࡿࡇ࡜ࢆ࠸࠺ࠋ㸧ཬࡧⱞ③ࡢ㍍ῶ㸦⛉Ꮫୖࡢ฼⏝࡟ᚲせ࡞㝈ᗘ࡟࠾࠸࡚㸪࡛ࡁࡿ㝈ࡾື≀࡟ⱞ③ࢆ୚࠼࡞࠸᪉ἲ࡟ࡼࡗ࡚ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࡇ࡜ࢆ࠸࠺ࠋ㸧ࡢ 3R
㸦Replacement㸪Reduction㸪Refinement㸧࡟ᇶ࡙ࡁ㸪㐺ṇ࡟ᐇ᪋ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ㸦ᐃ⩏㸧
➨ 2 ᮲ ࡇࡢつ⛬࡟࠾࠸࡚㸪ḟࡢྛྕ࡟ᥖࡆࡿ⏝ㄒࡢព⩏ࡣ㸪ࡑࢀࡒࢀᙜヱྛྕ࡟ᐃࡵࡿ࡜ࡇࢁ࡟ࡼࡿࠋ୍ࠕ㒊ᒁ➼ࠖ࡜ࡣ㸪Ꮫ㒊㸪◊✲⛉㸪㧗➼◊✲㝔㸪ὶᇦᅪ⛉Ꮫ◊✲ࢭࣥࢱ࣮ཬࡧ་Ꮫ㒊㝃ᒓ⑓㝔ࢆ࠸࠺ࠋ஧ࠕ㒊ᒁ㛗ࠖ࡜ࡣ㸪๓ྕ࡟つᐃࡍࡿ㒊ᒁ➼ࡢ㛗ࢆ࠸࠺ࠋ୕ࠕື≀ᐇ㦂➼ࠖ࡜ࡣ㸪ḟྕ࡟つᐃࡍࡿᐇ㦂ື≀ࢆᩍ⫱㸪ヨ㦂◊✲ཪࡣ⏕≀Ꮫⓗ〇๣ࡢ〇㐀ࡢ⏝ࡑࡢ௚ࡢ⛉Ꮫୖࡢ฼⏝࡟౪ࡍࡿࡇ࡜ࢆ࠸࠺ࠋ

ᅄࠕᐇ㦂ື≀ࠖ࡜ࡣ㸪ື≀ᐇ㦂➼ࡢ฼⏝࡟౪ࡍࡿࡓࡵ㸪᪋タ➼࡛㣫㣴ཪࡣಖ⟶ࡋ࡚࠸ࡿ့ங㢮㸪㫽㢮ཪࡣ∐⹸㢮࡟ᒓࡍࡿື≀㸦᪋タ➼࡟ᑟධࡍࡿࡓࡵ࡟㍺㏦୰ࡢࡶࡢࢆྵࡴࠋ)ࢆ࠸࠺ࠋ

஬ࠕ᪋タ➼ࠖ࡜ࡣ㸪㣫㣴ಖ⟶᪋タཬࡧᐇ㦂ᐊࢆ࠸࠺ࠋ

භࠕ㣫㣴ಖ⟶᪋タࠖ࡜ࡣ㸪ᐇ㦂ື≀ࢆᜏᖖⓗ࡟㣫㣴ⱝࡋࡃࡣಖ⟶ཪࡣື≀ᐇ㦂➼ࢆ⾜࠺᪋タ࣭タ
ഛࢆ࠸࠺ࠋ

୐

ࠕᐇ㦂ᐊࠖ࡜ࡣ㸪ᐇ㦂ື≀࡟ᐇ㦂᧯స㸦48 ᫬㛫௨ෆࡢ୍᫬ⓗಖ⟶ࢆྵࡴࠋ㸧ࢆ⾜࠺ື≀ᐇ㦂
ᐊࢆ࠸࠺ࠋ

ඵ

ࠕື≀ᐇ㦂ィ⏬ࠖ࡜ࡣ㸪ື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿィ⏬ࢆ࠸࠺ࠋ஑ࠕ⟶⌮⪅ࠖ࡜ࡣ㸪Ꮫ㛗ࡢ࿨ࢆཷࡅ㸪ᐇ㦂ື≀ཬࡧ᪋タ➼ࢆ⟶⌮ࡍࡿ㒊ᒁ㛗ࢆ࠸࠺ࠋ༑ࠕᐇ㦂ື≀⟶⌮⪅ࠖ࡜ࡣ㸪㒊ᒁ㛗ࢆ⿵బࡋ㸪ᐇ㦂ື≀࡟㛵ࡍࡿ▱㆑ཬࡧ⤒㦂ࢆ᭷ࡍࡿᐇ㦂ື≀ࡢ⟶⌮ࢆᢸᙜࡍࡿ⪅ࢆ࠸࠺ࠋ༑୍ ࠕື≀ᐇ㦂ᐇ᪋⪅ࠖ࡜ࡣ㸪ື≀ᐇ㦂➼ࢆᐇ᪋ࡍࡿ⪅ࢆ࠸࠺ࠋ༑஧ ࠕື≀ᐇ㦂㈐௵⪅ࠖ࡜ࡣ㸪ື≀ᐇ㦂ᐇ᪋⪅ࡢ࠺ࡕ㸪ື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿᴗົࢆ⤫ᣓࡍࡿ⪅ࢆ࠸࠺ࠋ༑୕ ࠕ㣫㣴⪅ࠖ࡜ࡣ㸪ᐇ㦂ື≀⟶⌮⪅ཪࡣື≀ᐇ㦂ᐇ᪋⪅ࡢୗ࡛ᐇ㦂ື≀ࡢ㣫㣴ཪࡣಖ⟶࡟ᚑ஦ࡍࡿ⪅ࢆ࠸࠺ࠋ༑ᅄ ࠕ⟶⌮⪅➼ࠖ࡜ࡣ㸪Ꮫ㛗㸪⟶⌮⪅㸪ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࢆ࠸࠺ࠋ༑஬ ࠕᣦ㔪➼ࠖ࡜ࡣ㸪◊✲ᶵ㛵➼࡟࠾ࡅࡿື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿᇶᮏᣦ㔪㸦ᖹᡂ 18 ᖺᩥ㒊⛉Ꮫ┬࿌♧➨ 71 ྕࠋ௨ୗࠕᇶᮏᣦ㔪ࠖ࡜࠸࠺ࠋ㸧㸪ື≀ᐇ㦂➼࡟㛵ࡋ࡚⾜ᨻᶵ㛵ࡢᐃࡵࡿᇶᮏ
ᣦ㔪ཬࡧ᪥ᮏᏛ⾡఍㆟ࡀసᡂࡋࡓࠕື≀ᐇ㦂ࡢ㐺ṇ࡞ᐇ᪋࡟ྥࡅࡓ࢞࢖ࢻࣛ࢖ࣥ㸦ᖹᡂ 18 ᖺ 6᭶㸧ࠖࢆ࠸࠺ࠋ
㸦㐺⏝⠊ᅖ㸧
➨ 3 ᮲ ࡇࡢつ⛬ࡣ㸪ᮏᏛ࡟࠾࠸࡚ᐇ᪋ࡉࢀࡿ့ங㢮㸪㫽㢮㸪∐⹸㢮ࡢ⏕యࢆ⏝࠸ࡿ඲࡚ࡢື≀ᐇ㦂➼࡟㐺⏝ࡍࡿࠋ
2ື≀ᐇ㦂㈐௵⪅ࡣ㸪ື≀ᐇ㦂➼ࡢᐇ᪋ࢆᮏᏛ௨እࡢᶵ㛵࡟ጤク➼ࡍࡿሙྜ㸪ጤクඛ࡟࠾࠸࡚ࡶ㸪ᇶᮏᣦ㔪ཪࡣ௚┬ᗇࡢᐃࡵࡿື≀ᐇ㦂➼࡟㛵ࡍࡿᇶᮏᣦ㔪࡟ᇶ࡙ࡁ㸪ື≀ᐇ㦂➼ࡀᐇ᪋ࡉࢀࡿࡇ࡜
ࢆ☜ㄆࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸦Ꮫ㛗ࡢ㈐ົ㸧➨ 4 ᮲ Ꮫ㛗ࡣ㸪ᮏᏛ࡟࠾ࡅࡿື≀ᐇ㦂➼ࡢ㐺ṇ࡞ᐇ᪋୪ࡧ࡟ᐇ㦂ື≀ࡢ㣫㣴ཬࡧಖ⟶ࡢ᭱⤊ⓗ࡞㈐௵⪅࡜ࡋ࡚⥲ᣓࡍࡿࠋ2ື≀ᐇ㦂ィ⏬ࡢᢎㄆ㸪ᐇ᪋≧ἣཬࡧ⤖ᯝࡢᢕᥱ㸪㣫㣴ಖ⟶᪋タཬࡧᐇ㦂ᐊࡢᢎㄆ㸪ᩍ⫱カ⦎㸪⮬ᕫⅬ᳨࣭ホ౯㸪᝟ሗබ㛤㸪ࡑࡢ௚ື≀ᐇ㦂➼࡟㛵ࡍࡿᴗົࡣ㸪Ꮫ㛗ࡢጤ௵࡟ࡼࡾḟ᮲࡟ᐃࡵࡿື≀ᐇ㦂ጤဨ఍ࡀ⾜࠺ࠋ㸦ື≀ᐇ㦂ጤဨ఍㸧➨ 5 ᮲ ື≀ᐇ㦂ጤဨ఍㸦௨ୗࠕጤဨ఍ࠖ࡜࠸࠺ࠋ㸧ࡣ㸪ḟࡢྛྕ࡟ᥖࡆࡿ஦㡯ࢆᑂ㆟ཪࡣㄪᰝࡋ㸪Ꮫ㛗࡟ሗ࿌ཪࡣຓゝࢆ⾜࠺ࠋ୍ື≀ᐇ㦂ィ⏬ࡀᣦ㔪➼ཬࡧࡇࡢつ⛬࡟㐺ྜࡋ࡚࠸ࡿࡇ࡜ࠋ

஧ື≀ᐇ㦂ィ⏬ࡢᐇ᪋≧ἣཬࡧ⤖ᯝ࡟㛵ࡍࡿࡇ࡜ࠋ୕᪋タ➼ཬࡧᐇ㦂ື≀ࡢ㣫⫱ಖ⟶≧ἣ࡟㛵ࡍࡿࡇ࡜ࠋ

ᅄື≀ᐇ㦂ཬࡧᐇ㦂ື≀ࡢ㐺ṇ࡞ྲྀᢅ࠸୪ࡧ࡟㛵ಀἲ௧➼࡟㛵ࡍࡿᩍ⫱カ⦎ࡢෆᐜཪࡣయไ࡟㛵
ࡍࡿࡇ࡜ࠋ

஬

⮬ᕫⅬ᳨࣭ホ౯࡟㛵ࡍࡿࡇ࡜ࠋභ᪋タ➼ࡢ฼⏝࡟㛵ࡍࡿࡇ࡜ࠋ୐᪋タ➼ࡢ⎔ቃಖ඲࡟㛵ࡍࡿࡇ࡜ࠋ

ඵࡑࡢ௚㸪ື≀ᐇ㦂➼ࡢ㐺ṇ࡞ᐇ᪋ࡢࡓࡵࡢᚲせ஦㡯࡟㛵ࡍࡿࡇ࡜ࠋ㸦⤌⧊㸧
➨ 6 ᮲ ጤဨ఍ࡣ㸪ḟࡢྛྕ࡟ᥖࡆࡿ⪅ࢆࡶࡗ࡚⤌⧊ࡍࡿࠋ୍་Ꮫ⣔◊✲⛉ཬࡧᛂ⏝⏕≀⛉Ꮫ㒊࠿ࡽ㑅ฟࡉࢀࡓື≀ᐇ㦂➼ཪࡣᐇ㦂ື≀࡟㛵ࡋ࡚ඃࢀࡓ㆑ぢࢆ᭷ࡍࡿ኱Ꮫᩍဨ ྛ 2 ே



஧

ᩍ⫱Ꮫ㒊ཬࡧᆅᇦ⛉Ꮫ㒊࠿ࡽ㑅ฟࡉࢀࡓࡑࡢ௚Ꮫ㆑⤒㦂ࢆ᭷ࡍࡿ኱Ꮫᩍဨ㸦ேᩥ࣭♫఍⛉Ꮫ⣔ࢆᑓᨷࡍࡿ኱Ꮫᩍဨ࡟㝈ࡿࠋ㸧 ྛ 1 ே୕ᕤᏛ㒊࠿ࡽ㑅ฟࡉࢀࡓື≀ᐇ㦂➼ⱝࡋࡃࡣᐇ㦂ື≀࡟㛵ࡋ࡚ඃࢀࡓ㆑ぢࢆ᭷ࡍࡿ኱Ꮫᩍဨཪࡣ
ࡑࡢ௚Ꮫ㆑⤒㦂ࢆ᭷ࡍࡿ኱Ꮫᩍဨ 1 ேᅄື≀ᐇ㦂ࢆᐇ᪋ࡋ࡚࠸ࡿ㒊ᒁ➼ࡢື≀ᐇ㦂࡟ᦠࢃࡿ኱Ꮫᩍဨࡢ࠺ࡕ࠿ࡽ㑅ฟࡉࢀࡓື≀ᐇ㦂➼ཪࡣᐇ㦂ື≀࡟㛵ࡋ࡚ඃࢀࡓ㆑ぢࢆ᭷ࡍࡿ⪅ 1 ே2஬◊✲௻⏬ㄢ㛗

භࡑࡢ௚ጤဨ఍ࡀᚲせ࡜ㄆࡵࡿ⪅๓㡯➨ 1 ྕ࠿ࡽ➨ 4 ྕࡲ࡛ཬࡧ➨ 6 ྕ࡟つᐃࡍࡿጤဨࡣ㸪Ꮫ㛗ࡀጤკࡍࡿࠋ㸦௵ᮇ㸧

➨ 7 ᮲ ๓᮲➨ 1 㡯➨ 1 ྕ࠿ࡽ➨ 4 ྕࡲ࡛ཬࡧ➨ 6 ྕ࡟つᐃࡍࡿጤဨࡢ௵ᮇࡣ 2 ᖺ࡜ࡋ㸪෌௵ࢆጉࡆ
࡞࠸ࠋࡓࡔࡋ㸪ጤဨ࡟Ḟဨࡀ⏕ࡌࡓ࡜ࡁࡢ⿵Ḟጤဨࡢ௵ᮇࡣ㸪๓௵⪅ࡢṧ௵ᮇ㛫࡜ࡍࡿࠋ㸦ጤဨ㛗➼㸧
➨ 8 ᮲ ጤဨ఍࡟ጤဨ㛗ཬࡧ๪ጤဨ㛗ࢆ⨨ࡃࠋ
2ጤဨ㛗ࡣ㸪◊✲ࢆᢸᙜࡍࡿ๪Ꮫ㛗ࡀᣦྡࡍࡿጤဨࢆࡶࡗ࡚඘࡚ࡿࠋ

3ጤဨ㛗ࡣ㸪ጤဨ఍ࢆᣍ㞟ࡋ㸪ࡑࡢ㆟㛗࡜࡞ࡿࠋ4๪ጤဨ㛗ࡣ㸪ጤဨ㛗ࢆ⿵బࡋ㸪ጤဨ㛗࡟஦ᨾࡀ࠶ࡿ࡜ࡁࡣ㸪ࡑࡢ⫋ົࢆ௦⌮ࡍࡿࠋ

5๪ጤဨ㛗ࡣ㸪ḟࡢྛྕ࡟ᥖࡆࡿ⪅ࢆࡶࡗ࡚඘࡚ࡿࠋ
୍ ➨ 6 ᮲➨ 1 㡯➨ 1 ྕཪࡣ➨ 4 ྕࡢつᐃ࡟ࡼࡾ㑅ฟࡉࢀࡓጤဨ࡛ጤဨ㛗ࡀᣦྡࡍࡿࡶࡢ 2 ே
㸦఍㆟㸧➨ 9 ᮲ ጤဨ఍ࡣ㸪ጤဨࡢ 3 ศࡢ 2 ௨ୖࡢฟᖍࢆࡶࡗ࡚ᡂ❧ࡍࡿࠋ
2㆟஦ࡣ㸪ฟᖍጤဨࡢ㐣༙ᩘࡢྠពࢆࡶࡗ࡚Ỵࡋ㸪ྍྰྠᩘࡢ࡜ࡁࡣ㸪㆟㛗ࡢỴࡍࡿ࡜ࡇࢁ࡟ࡼࡿࠋ3ື≀ᐇ㦂ィ⏬ࡢᑂᰝ࡟ࡘ࠸࡚ࡣ㸪ḟࡢุᐃ࡟ࡼࡾ⾜࠺ࡶࡢ࡜ࡍࡿࠋ୍ᢎㄆ஧ ᮲௳௜ࡁᢎㄆ
୕ ୙ᢎㄆ
ᅄ 㠀ヱᙜ
4

ጤဨࡣ㸪⮬ࡽࡀື≀ᐇ㦂㈐௵⪅࡜࡞ࡿື≀ᐇ㦂ィ⏬ࡢᑂ㆟࡟ຍࢃࡿࡇ࡜ࡣ࡛ࡁ࡞࠸ࠋ

5ᑂᰝࡢᑐ㇟࡜࡞ࡿື≀ᐇ㦂ᐇ᪋⪅ࡣ㸪ጤဨ఍ࡢせㄳࡀ࠶ࡗࡓሙྜ࡟ࡣ㸪ጤဨ఍࡛ᙜヱᐇ㦂ィ⏬ࢆㄝ᫂ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦Ᏺ⛎⩏ົ㸧

➨ 10 ᮲ ጤဨࡣ㸪ື≀ᐇ㦂ィ⏬࡟㛵ࡋ࡚▱ࡾᚓࡓ᝟ሗࢆ➨୕⪅࡟₃࠼࠸ࡋ࡚ࡣ࡞ࡽ࡞࠸ࠋ
㸦ጤဨ௨እࡢ⪅ࡢฟᖍ㸧➨ 11 ᮲ ጤဨ఍ࡀᚲせ࡜ㄆࡵࡿ࡜ࡁࡣ㸪ጤဨ௨እࡢ⪅ࡢฟᖍࢆồࡵ࡚㸪ࡑࡢពぢࢆ⫈ࡃࡇ࡜ࡀ࡛ࡁ
ࡿࠋ➨ 12 ᮲ ๐㝖
㸦ᗢົ㸧



➨ 13 ᮲ ጤဨ఍ࡢᗢົࡣ㸪་Ꮫ⣔◊✲⛉࣭་Ꮫ㒊஦ົ㒊ཬࡧᛂ⏝⏕≀⛉Ꮫ㒊஦ົ㒊ࡢ༠ຊࢆᚓ࡚㸪◊✲᥎㐍㒊◊✲௻⏬ㄢ࡟࠾࠸࡚ฎ⌮ࡍࡿࠋ
2◊✲᥎㐍㒊◊✲௻⏬ㄢࡣ㸪ጤဨ఍㛤ദ࡟㛵ࡍࡿ㆟஦㘓➼ࡢసᡂཬࡧಖᏑ➼ࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞
࠸ࠋ㸦ᐇ㦂ື≀⟶⌮⪅㸧➨ 14 ᮲ ື≀ᐇ㦂ࢆ⾜࠺㒊ᒁ࡟㸪ᐇ㦂ື≀⟶⌮⪅ࢆᑡ࡞ࡃ࡜ࡶ 1 ே⨨ࡃࡶࡢ࡜ࡍࡿࠋ
2 ᐇ㦂ື≀⟶⌮⪅ࡣ㸪ᐇ㦂ື≀࡟㛵ࡍࡿ▱㆑ཬࡧ⤒㦂ࢆ᭷ࡍࡿ⪅ࡢ࠺ࡕ࠿ࡽ㸪ᙜヱ㒊ᒁ㛗ࡀ௵࿨ࡍࡿࠋ
3 ᐇ㦂ື≀⟶⌮⪅ࡣ㸪㒊ᒁ㛗ࢆ⿵బࡋ㸪ᐇ㦂ື≀ཬࡧ᪋タ➼ࡢ⟶⌮ࢆ⾜࠺ࠋ㸦ື≀ᐇ㦂ィ⏬ࡢ❧᱌㸪ᑂᰝ㸪ᡭ⥆ࡁ㸧
➨ 15 ᮲ ື≀ᐇ㦂㈐௵⪅ࡣ㸪ື≀ᐇ㦂➼࡟ࡼࡾྲྀᚓࡉࢀࡿࢹ࣮ࢱࡢಙ㢗ᛶࢆ☜ಖࡍࡿほⅬ࠿ࡽ㸪ḟ࡟ᥖࡆࡿ஦㡯ࢆ㋃ࡲ࠼࡚ື≀ᐇ㦂ィ⏬ࢆ❧᱌ࡋ㸪ື≀ᐇ㦂ィ⏬᭩㸦ู⣬ᵝᘧ➨ 1 ྕ㸧ࢆᏛ㛗࡟ᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
୍◊✲ࡢ┠ⓗ㸪ព⩏ཬࡧᚲせᛶ஧௦᭰ἲࢆ⪃៖ࡋ࡚㸪ᐇ㦂ື≀ࢆ㐺ษ࡟฼⏝ࡍࡿࡇ࡜ࠋ

୕ᐇ㦂ື≀ࡢ౑⏝ᩘ๐ῶࡢࡓࡵ㸪ື≀ᐇ㦂➼ࡢ┠ⓗ࡟㐺ࡋࡓᐇ㦂ື≀✀ࡢ㑅ᐃ㸪ື≀ᐇ㦂ᡂ⦼ࡢ⢭ᗘ࡜෌⌧ᛶࢆᕥྑࡍࡿᐇ㦂ື≀ࡢᩘ㸪㑇ఏᏛⓗཬࡧᚤ⏕≀Ꮫⓗရ㉁୪ࡧ࡟㣫㣴᮲௳ࢆ⪃៖ࡍࡿࡇ࡜ࠋᅄ

ⱞ③ࡢ㍍ῶ࡟ࡼࡾື≀ᐇ㦂➼ࢆ㐺ษ࡟⾜࠺ࡇ࡜ࠋ஬ⱞ③ᗘࡢ㧗࠸ື≀ᐇ㦂➼㸪౛࠼ࡤ㸪⮴Ṛⓗ࡞ẘᛶヨ㦂㸪ឤᰁᐇ㦂㸪ᨺᑕ⥺↷ᑕᐇ㦂➼ࢆ⾜࠺ሙྜࡣ㸪ື≀ᐇ㦂➼ࢆィ⏬ࡍࡿẁ㝵࡛ே㐨ⓗ࢚ࣥࢻ࣏࢖ࣥࢺ㸦ᐇ㦂ື≀ࢆ⃭ࡋ࠸ⱞ③࠿ࡽゎᨺࡍࡿࡓࡵࡢᐇ㦂ࢆᡴࡕษࡿࢱ࢖࣑ࣥࢢ㸧ࡢタᐃࢆ᳨ウࡍࡿࡇ࡜ࠋ

2๓㡯ࡢື≀ᐇ㦂ィ⏬᭩࡟࠾࠸࡚⏦ㄳྍ⬟࡞ᐇ㦂ᐇ᪋ᮇ㛫ࡣ㸪ື≀ᐇ㦂ィ⏬ࡢᢎㄆࢆᚓ࡚࠿ࡽ᭱㛗 3ᖺ㛫࡜ࡍࡿࠋ

3ື≀ᐇ㦂㈐௵⪅ࡣ㸪ື≀ᐇ㦂➼ࡢ㛤ጞᚋ࡟࠾࠸࡚㸪ᙜヱᐇ㦂ィ⏬ࡢෆᐜࢆኚ᭦ཪࡣ㏣ຍࡍࡿᚲせࡀ࠶ࡿሙྜࡣ㸪ື≀ᐇ㦂ィ⏬㸦ኚ᭦࣭㏣ຍ㸧ᢎㄆ⏦ㄳ᭩㸦ู⣬ᵝᘧ➨ 2 ྕ㸧ࢆᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

4Ꮫ㛗ࡣ㸪ື≀ᐇ㦂㈐௵⪅࠿ࡽ➨ 1 㡯ཬࡧ๓㡯࡟つᐃࡍࡿ᭩㢮ࡢᥦฟࢆཷࡅࡓ࡜ࡁࡣ㸪ጤဨ఍࡟ᑂ
ᰝࢆ௜㆟ࡋ㸪ࡑࡢ⤖ᯝࢆᙜヱື≀ᐇ㦂㈐௵⪅࡟㏻▱ࡍࡿࠋ5ື≀ᐇ㦂㈐௵⪅ࡣ㸪ື≀ᐇ㦂ィ⏬࡟ࡘ࠸࡚Ꮫ㛗ࡢᢎㄆࢆᚓࡓᚋ࡛࡞ࡅࢀࡤ㸪ື≀ᐇ㦂➼ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋ
㸦ື≀ᐇ㦂ࡢᐇ᪋㸧➨ 16 ᮲ ື≀ᐇ㦂ᐇ᪋⪅ࡣ㸪ື≀ᐇ㦂➼ࡢᐇ᪋࡟ᙜࡓࡗ࡚㸪ື≀ឡㆤἲ㸪㣫㣴ಖ⟶ᇶ‽㸪ᣦ㔪➼࡟๎ࡍࡿ࡜࡜ࡶ࡟㸪≉࡟ḟ࡟ᥖࡆࡿ஦㡯ࢆ㑂Ᏺࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
୍㐺ษ࡟⥔ᣢ⟶⌮ࡉࢀࡓ᪋タ➼࡟࠾࠸࡚ື≀ᐇ㦂➼ࢆ⾜࠺ࡇ࡜ࠋ஧ື≀ᐇ㦂ィ⏬᭩࡟グ㍕ࡉࢀࡓ஦㡯ཬࡧḟ࡟ᥖࡆࡿ஦㡯ࢆ㑂Ᏺࡍࡿࡇ࡜ࠋ
࢖㐺ษ࡞㯞㓉⸆㸪㙠③⸆➼ࡢ฼⏝ࣟᐇ㦂ࡢ⤊஢ࡢ᫬ᮇ㸦ே㐨ⓗ࢚ࣥࢻ࣏࢖ࣥࢺࢆྵࡴࠋ㸧ࡢ㓄៖

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ࣁ

㐺ษ࡞⾡ᚋ⟶⌮

ࢽ㐺ษ࡞ᏳᴦṚࡢ㑅ᢥ୕Ᏻ඲⟶⌮࡟ὀពࢆᡶ࠺࡭ࡁᐇ㦂㸦≀⌮ⓗ㸪໬Ꮫⓗ࡟༴㝤࡞ᮦᩱ㸪⑓ཎయ㸪㑇ఏᏊ⤌᥮࠼ື≀➼ࢆ⏝࠸ࡿᐇ㦂㸧࡟ࡘ࠸࡚ࡣ㸪㛵ಀἲ௧➼ཬࡧᮏᏛ࡟࠾ࡅࡿ㛵㐃ࡍࡿつ⛬➼࡟ᚑ࠺ࡇ࡜ࠋ

ᅄ≀⌮ⓗ㸪໬Ꮫⓗ࡟༴㝤࡞ᮦᩱཪࡣ⑓ཎయ➼ࢆᢅ࠺ື≀ᐇ㦂➼࡟ࡘ࠸࡚㸪Ᏻ඲ࡢࡓࡵࡢ㐺ษ࡞᪋タࡸタഛࢆ☜ಖࡍࡿࡇ࡜ࠋ

2஬ᐇ㦂ᐇ᪋࡟ඛ❧ࡕᚲせ࡞ᐇ㦂ᡭᢏ➼ࡢ⩦ᚓ࡟ດࡵࡿࡇ࡜ࠋභ౵くᛶࡢ㧗࠸኱つᶍ࡞Ꮡ࿨ᡭ⾡࡟ᙜࡓࡗ࡚ࡣ㸪⤒㦂➼ࢆ᭷ࡍࡿ⪅ࡢᣦᑟୗ࡛⾜࠺ࡇ࡜ࠋື≀ᐇ㦂㈐௵⪅ࡣ㸪ື≀ᐇ㦂ィ⏬ࢆᐇ᪋ࡋᙜヱィ⏬ࢆ⤊஢ཪࡣᙜヱィ⏬ࢆ㏵୰࡛୰Ṇࡋࡓ࡜ࡁ࡟
ࡣ㸪ື≀ᐇ㦂ᡂᯝሗ࿌᭩㸦ู⣬ᵝᘧ➨ 3 ྕ㸧࡟ࡼࡾ౑⏝ື≀ᩘ㸪ィ⏬࠿ࡽࡢኚ᭦ࡢ᭷↓㸪ᡂᯝ➼࡟ࡘ࠸࡚Ꮫ㛗࡟ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

3๓㡯࡟つᐃࡍࡿሗ࿌᭩ࡣ㸪ື≀ᐇ㦂ィ⏬ࢆ⤊஢ࡋࡓ࡜ࡁ࡟࠶ࡗ࡚ࡣᙜヱᐇ㦂⤊஢᪥ࡢᒓࡍࡿᖺᗘ
ࡢ 3 ᭶ᮎࡲ࡛࡟㸪୰Ṇࡋࡓ࡜ࡁ࡟࠶ࡗ࡚ࡣ୰Ṇᚋ㏿ࡸ࠿࡟ᥦฟࡍࡿࡶࡢ࡜ࡍࡿࠋ

4ື≀ᐇ㦂㈐௵⪅ࡣ㸪ື≀ᐇ㦂➼ࡢᐇ᪋≧ἣ࡟ࡘ࠸࡚㸪ẖᖺ 1 ᅇ௨ୖ㸪⮬ᕫⅬ᳨ࢆ⾜࠸㸪ື≀ᐇ㦂ࡢ⮬ᕫⅬ᳨⚊㸦ู⣬ᵝᘧ➨ 4 ྕ㸧࡟ࡼࡾᏛ㛗࡬ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦㣫㣴ಖ⟶᪋タࡢタ⨨㸧➨ 17 ᮲ 㣫㣴ಖ⟶᪋タࢆタ⨨ࡍࡿሙྜࡣ㸪⟶⌮⪅ࡀ㣫㣴ಖ⟶᪋タタ⨨ᢎㄆ⏦ㄳ᭩㸦ู⣬ᵝᘧ➨ 5ྕ㸧ࢆᥦฟࡋ㸪Ꮫ㛗ࡢᢎㄆࢆᚓ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2㣫㣴ಖ⟶᪋タ⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣ㸪Ꮫ㛗ࡢᢎㄆࢆᚓࡓ㣫㣴ಖ⟶᪋タ࡛࡞ࡅࢀࡤ㸪ᙜヱ㣫㣴ಖ⟶᪋タ࡛ࡢ㣫㣴ⱝࡋࡃࡣಖ⟶ཪࡣື≀ᐇ㦂➼ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋ

3Ꮫ㛗ࡣ㸪⏦ㄳࡉࢀࡓ㣫㣴ಖ⟶᪋タࢆጤဨ఍࡟ㄪᰝࡉࡏ㸪ࡑࡢຓゝ࡟ࡼࡾ㸪ᢎㄆཪࡣ㠀ᢎㄆࢆỴᐃࡍࡿࠋ4㣫㣴ಖ⟶᪋タࡢ⟶⌮⪅ࡣ㸪㣫㣴ಖ⟶≧ἣ࡟ࡘ࠸࡚㸪ẖᖺ 1 ᅇ௨ୖ㸪⮬ᕫⅬ᳨ࢆ⾜࠸㸪ᐇ㦂ື≀㣫㣴ಖ⟶≧ἣࡢ⮬ᕫⅬ᳨⚊㸦ู⣬ᵝᘧ➨ 6 ྕ㸧࡟ࡼࡾᏛ㛗࡬ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦㣫㣴ಖ⟶᪋タࡢせ௳㸧➨ 18 ᮲ 㣫㣴ಖ⟶᪋タࡣ㸪ḟ࡟ᥖࡆࡿせ௳ࢆ‶ࡓࡉ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ୍㐺ษ࡞ ᗘ㸪‵ᗘ㸪᥮Ẽ㸪᫂ࡿࡉ➼ࢆಖࡘࡇ࡜ࡀ࡛ࡁࡿᵓ㐀➼࡛࠶ࡿࡇ࡜ࠋ

஧ᐇ㦂ື≀ࡢ✀㢮ࡸ㣫㣴ཪࡣಖ⟶ࡍࡿᩘ➼࡟ᛂࡌࡓ㣫⫱タഛࢆ᭷ࡍࡿࡇ࡜ࠋ

୕ᗋࡸෆቨ࡞࡝ࡢΎᤲ㸪ᾘẘ➼ࡀᐜ᫆࡞ᵓ㐀࡛㸪ჾᮦࡢὙίࡸᾘẘ➼ࢆ⾜࠺⾨⏕タഛࢆ᭷ࡍࡿࡇ࡜ࠋᅄᐇ㦂ື≀ࡀ㐓㉮ࡋ࡞࠸ᵓ㐀ཬࡧᙉᗘࢆ᭷ࡍࡿࡇ࡜ࠋ

஬⮯Ẽ㸪㦁㡢㸪ᗫᲠ≀➼࡟ࡼࡿ࿘㎶⎔ቃ࡬ࡢᝏᙳ㡪ࢆ㜵Ṇࡍࡿᥐ⨨ࡀ࡜ࡽࢀ࡚࠸ࡿࡇ࡜ࠋ

භᐇ㦂ື≀⟶⌮⪅ࡀ࠾࠿ࢀ࡚࠸ࡿࡇ࡜ࠋ

㸦ᐇ㦂ᐊࡢタ⨨㸧➨ 19 ᮲ 㣫㣴ಖ⟶᪋タ௨እ࡟࠾࠸࡚㸪ᐇ㦂ᐊࢆタ⨨ࡍࡿሙྜࡣ㸪⟶⌮⪅ࡀᐇ㦂ᐊタ⨨ᢎㄆ⏦ㄳ᭩㸦ู⣬ᵝᘧ➨ 7 ྕ㸧ࢆᥦฟࡋ㸪Ꮫ㛗ࡢᢎㄆࢆᚓ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2 Ꮫ㛗ࡣ㸪⏦ㄳࡉࢀࡓᐇ㦂ᐊࢆጤဨ఍࡟ㄪᰝࡉࡏ㸪ࡑࡢຓゝ࡟ࡼࡾ㸪ᢎㄆཪࡣ㠀ᢎㄆࢆỴᐃࡍࡿࠋ

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3

ᐇ㦂ᐊ⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣ㸪Ꮫ㛗ࡢᢎㄆࢆᚓࡓᐇ㦂ᐊ࡛࡞ࡅࢀࡤ㸪ᙜヱᐇ㦂ᐊ࡛ࡢື≀ᐇ㦂➼㸦48 ᫬㛫௨ෆࡢ୍᫬ⓗಖ⟶ࢆྵࡴࠋ㸧ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋ
㸦ᐇ㦂ᐊࡢせ௳㸧➨ 20 ᮲ ᐇ㦂ᐊࡣ㸪ḟ࡟ᥖࡆࡿせ௳ࢆ‶ࡓࡉ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
୍ᐇ㦂ື≀ࡀ㐓㉮ࡋ࡞࠸ᵓ㐀ཬࡧᙉᗘࢆ᭷ࡋ㸪ᐇ㦂ື≀ࡀᐊෆ࡛㐓㉮ࡋ࡚ࡶᤕ⋓ࡋࡸࡍ࠸⎔ቃࡀ⥔ᣢࡉࢀ࡚࠸ࡿࡇ࡜ࠋ

஧᤼ἥ≀ࡸ⾑ᾮ➼࡟ࡼࡿởᰁ࡟ᑐࡋ࡚Ύᤲࡸᾘẘࡀᐜ᫆࡞ᵓ㐀࡛࠶ࡿࡇ࡜ࠋ

୕ᖖ࡟Ύ₩࡞≧ែࢆಖࡕ㸪⮯Ẽ㸪㦁㡢㸪ᗫᲠ≀➼࡟ࡼࡿ࿘㎶⎔ቃ࡬ࡢᝏᙳ㡪ࢆ㜵Ṇࡍࡿᥐ⨨ࡀ࡜ࡽࢀ࡚࠸ࡿࡇ࡜ࠋ㸦᪋タ➼ࡢ⥔ᣢ⟶⌮ཬࡧᨵၿ㸧➨ 21 ᮲ ⟶⌮⪅ࡣ㸪ᐇ㦂ື≀ࡢ㐺ṇ࡞⟶⌮୪ࡧ࡟ື≀ᐇ㦂➼ࡢ㐙⾜࡟ᚲせ࡞᪋タ➼ࡢ⥔ᣢ⟶⌮ཬࡧᨵၿ࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2⟶⌮⪅ࡣ㸪ᐇ㦂ື≀ࡢ✀㢮㸪⩦ᛶ➼ࢆ⪃៖ࡋࡓ㣫㣴ཪࡣಖ⟶ࢆ⾜࠺ࡓࡵࡢ⎔ቃࡢ☜ಖࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ㸦᪋タ➼ࡢኚ᭦➼㸧➨ 21 ᮲ࡢ 2 ᪋タ➼ࡢタ⨨ᚋ㸪ᙜヱ᪋タ➼ࡢタ⨨ᢎㄆ⏦ㄳ᭩ࡢෆᐜࢆኚ᭦ཪࡣ㏣ຍࡍࡿሙྜࡣ㸪⟶⌮⪅ࡀ᪋タ➼㸦㣫㣴ಖ⟶᪋タ࣭ື≀ᐇ㦂ᐊ㸧ኚ᭦➼ᢎㄆ⏦ㄳ᭩㸦ู⣬ᵝᘧ➨ 8 ྕ㸧ࢆᥦฟࡋ㸪Ꮫ㛗ࡢᢎㄆࢆᚓ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ㸦᪋タ➼ࡢᗫṆ㸧➨ 22 ᮲ ᪋タ➼ࢆᗫṆࡍࡿሙྜࡣ㸪⟶⌮⪅ࡀ᪋タ➼㸦㣫㣴ಖ⟶᪋タ࣭ື≀ᐇ㦂ᐊ㸧ᗫṆᒆ㸦ู⣬ᵝᘧ➨ 9 ྕ㸧࡟ࡼࡾ㸪Ꮫ㛗࡟ᒆࡅฟ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2⟶⌮⪅ࡣ㸪ᚲせ࡟ᛂࡌ࡚㸪ື≀ᐇ㦂㈐௵⪅࡜༠ຊࡋ㸪㣫㣴ཪࡣಖ⟶୰ࡢᐇ㦂ື≀ࢆ௚ࡢ㣫㣴ಖ⟶᪋タ࡟ㆡࡾΏࡍࡼ࠺ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦㣫㣴ಖ⟶࣐ࢽࣗ࢔ࣝࡢసᡂ࡜࿘▱㸧➨ 23 ᮲ ⟶⌮⪅ཬࡧᐇ㦂ື≀⟶⌮⪅ࡣ㸪㣫㣴ಖ⟶ࡢ࣐ࢽࣗ࢔ࣝࢆᐃࡵ㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅࡟࿘▱ࡋ㑂Ᏺࡉࡏ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦ᐇ㦂ື≀ࡢ೺ᗣཬࡧᏳ඲ࡢಖᣢ㸧➨ 24 ᮲ ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅㸪㣫㣴⪅ࡣ㸪㣫㣴ಖ⟶ᇶ‽ࢆ㑂Ᏺࡋ㸪ᐇ㦂ື≀ࡢ೺ᗣཬࡧᏳ඲ࡢಖᣢ࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦ᐇ㦂ື≀ࡢᑟධ㸧➨ 25 ᮲ ⟶⌮⪅ࡣ㸪ᐇ㦂ື≀ࡢᑟධ࡟ᙜࡓࡾ㸪㛵㐃ἲ௧ࡸᣦ㔪➼࡟ᇶ࡙ࡁ㐺ṇ࡟⟶⌮ࡉࢀ࡚࠸ࡿᶵ
㛵ࡼࡾᑟධࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2ᐇ㦂ື≀⟶⌮⪅ࡣ㸪ᐇ㦂ື≀ࡢᑟධ࡟ᙜࡓࡾ㸪㐺ษ࡞᳨␿㸪㝸㞳㣫⫱➼ࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋ

3ᐇ㦂ື≀⟶⌮⪅ࡣ㸪ᐇ㦂ື≀ࡢ㣫㣴⎔ቃ࡬ࡢ㡰໬࣭㡰ᛂࢆᅗࡿࡓࡵࡢᚲせ࡞ᥐ⨨ࢆㅮࡌࡿࡶࡢ࡜
ࡍࡿࠋ㸦ᐇ㦂ື≀ࡢ㣫⫱࣭⟶⌮㸧

➨ 26 ᮲ ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣ㸪ᐇ㦂ື≀ࡢ⏕⌮㸪⏕ែ㸪⩦ᛶ➼࡟ᛂࡌ࡚㸪㐺ษ࡟⤥㣵࣭⤥Ỉࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

㸦೺ᗣ⟶⌮㸧➨ 27 ᮲ ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣ㸪ᐇ㦂┠ⓗ௨እࡢയᐖࡸ⑌⑓ࢆண㜵ࡍࡿࡓࡵ㸪ᐇ㦂ື≀࡟ᚲせ࡞೺ᗣ⟶⌮࡟㓄៖ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣ㸪ᐇ㦂ື≀ࡢ✀㢮㸪⩦ᛶ➼ࢆ⪃៖ࡋࡓ㣫⫱ཪࡣಖ⟶ࢆ⾜࠺ࡓࡵࡢ⎔ቃࡢ☜ಖࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

3ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣ㸪ᐇ㦂┠ⓗ௨እࡢയᐖࡸ⑌⑓࡟࠿࠿ࡗࡓሙྜ㸪ᐇ㦂ື≀࡟㐺ษ࡞἞⒪➼ࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦␗✀ཪࡣ」ᩘື≀ࡢ㣫⫱㸧

➨ 28 ᮲ ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣ㸪␗✀ཪࡣ」ᩘࡢᐇ㦂ື≀ࢆྠ୍᪋タෆ࡛㣫㣴ཪࡣಖ⟶ࡍࡿሙྜ㸪ࡑࡢ⤌ࡳྜࢃࡏࢆ⪃៖ࡋ㸪཰ᐜࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦グ㘓ࡢಖᏑཬࡧሗ࿌㸧➨ 29 ᮲ ⟶⌮⪅➼ࡣ㸪ᐇ㦂ື≀ࡢධᡭඛ㸪㣫⫱ᒚṔ㸪⑓Ṕ➼࡟㛵ࡍࡿグ㘓ࢆᩚഛཬࡧಖᏑࡋ࡞ࡅࢀ
ࡤ࡞ࡽ࡞࠸ࠋ
2⟶⌮⪅ࡣ㸪ᖺᗘࡈ࡜࡟㣫㣴ಖ⟶ࡋࡓᐇ㦂ື≀ࡢ✀㢮࡜ᩘ➼࡟ࡘ࠸࡚㸪Ꮫ㛗࡟ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ
࡞࠸ࠋ㸦ᐇ㦂ື≀ࡢㆡΏ㸧➨ 30 ᮲ ⟶⌮⪅➼ࡣ㸪ᐇ㦂ື≀ࡢㆡΏ࡟ᙜࡓࡾ㸪ࡑࡢ≉ᛶ㸪㣫㣴ཪࡣಖ⟶ࡢ᪉ἲ㸪ឤᰁᛶ⑌⑓➼࡟㛵ࡍࡿ᝟ሗࢆᥦ౪ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦ᐇ㦂ື≀ࡢ㍺㏦㸧
➨ 31 ᮲ ⟶⌮⪅➼ࡣ㸪ᐇ㦂ື≀ࡢ㍺㏦࡟ᙜࡓࡾ㸪㣫㣴ಖ⟶ᇶ‽ࢆ㑂Ᏺࡋ㸪ᐇ㦂ື≀ࡢ೺ᗣཬࡧᏳ඲
ࡢ☜ಖ㸪ே࡬ࡢ༴ᐖ㜵Ṇ࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦༴ᐖ㜵Ṇ㸧
➨ 32 ᮲ ⟶⌮⪅ࡣ㸪㐓㉮ࡋࡓᐇ㦂ື≀ࡢᤕ⋓ࡢ᪉ἲ➼ࢆᐃࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2⟶⌮⪅ࡣ㸪ே࡟༴ᐖࢆຍ࠼ࡿ➼ࡢᜍࢀࡢ࠶ࡿᐇ㦂ື≀ࡀ᪋タ➼እ࡟㐓㉮ࡋࡓሙྜ࡟ࡣ㸪㏿ࡸ࠿࡟◊✲᥎㐍㒊◊✲᥎㐍ㄢ࡬㐃⤡ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

3⟶⌮⪅ࡣ㸪ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡀ㸪ᐇ㦂ື≀⏤᮶ࡢឤᰁ⑕ཬࡧᐇ㦂ື≀࡟ࡼࡿညയ㸪࢔ࣞࣝࢠ࣮➼࡟ᑐࡋ࡚㸪ண㜵ཬࡧⓎ⏕᫬ࡢᚲせ࡞ᥐ⨨ࢆㅮࡌ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

4⟶⌮⪅ࡣ㸪ẘ࡬ࡧ➼ࡢ᭷ẘື≀ࡢ㣫㣴ཪࡣಖ⟶ࢆࡍࡿሙྜࡣ㸪ே࡬ࡢ༴ᐖࡢⓎ⏕ࡢ㜵Ṇࡢࡓࡵ㸪㣫㣴ಖ⟶ᇶ‽࡟ᇶ࡙ࡁᚲせ࡞஦㡯ࢆู㏵ᐃࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

5⟶⌮⪅➼ࡣ㸪ᐇ㦂ື≀ࡢ㣫㣴ཬࡧಖ⟶୪ࡧ࡟ື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ಀࡢ࡞࠸⪅ࡀᐇ㦂ື≀➼࡟᥋ࡍࡿࡇ࡜ࡢ࡞࠸ࡼ࠺㸪ᚲせ࡞ᥐ⨨ࢆㅮࡌ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦⥭ᛴ᫬ࡢᑐᛂ㸧➨ 33 ᮲ ⟶⌮⪅ࡣ㸪ᆅ㟈㸪ⅆ⅏㸪ே࡜ື≀ࡢඹ㏻ឤᰁ⑕ࡢⓎ⏕᫬➼ࡢ⥭ᛴ᫬࡟ᇳࡿ࡭ࡁᥐ⨨ࡢィ⏬
ࢆ࠶ࡽ࠿ࡌࡵసᡂࡋ㸪㛵ಀ⪅࡟ᑐࡋ࡚࿘▱ࢆᅗࡽ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2⟶⌮⪅➼ࡣ㸪⥭ᛴ஦ែⓎ⏕᫬࡟࠾࠸࡚㸪ᐇ㦂ື≀ࡢಖㆤ㸪ᐇ㦂ື≀ࡢ㐓㉮࡟ࡼࡿ༴ᐖ㜵Ṇ࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦ᩍ⫱カ⦎㸧

➨ 34 ᮲ ᐇ㦂ື≀⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣ㸪ḟ࡟ᥖࡆࡿ஦㡯࡟㛵ࡋ࡚㸪ጤဨ఍ࡀᐇ᪋ࡍࡿᩍ⫱カ⦎ࢆཷࡅ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ୍ 㛵㐃ἲ௧㸪ᣦ㔪㸪ᮏᏛࡢᐃࡵࡿつ⛬➼஧ ື≀ᐇ㦂➼ࡢ᪉ἲ࡟㛵ࡍࡿᇶᮏⓗ஦㡯୕ᐇ㦂ື≀ࡢ㣫㣴ཪࡣಖ⟶࡟㛵ࡍࡿᇶᮏⓗ஦㡯ᅄ Ᏻ඲☜ಖ㸪Ᏻ඲⟶⌮࡟㛵ࡍࡿ஦㡯஬ ࡑࡢ௚㸪㐺ษ࡞ື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿ஦㡯2ᩍ⫱カ⦎ࡢᐇ᪋᪥㸪ᩍ⫱ෆᐜ㸪ㅮᖌཬࡧཷㅮ⪅ྡࡣ㸪◊✲᥎㐍㒊◊✲௻⏬ㄢࡀグ㘓ࡋಖᏑࡍࡿࠋ
㸦⮬ᕫⅬ᳨㸧

➨ 35 ᮲ ጤဨ఍ࡣ㸪㣫㣴ಖ⟶ᇶ‽ཬࡧᇶᮏᣦ㔪࡬ࡢ㐺ྜᛶ࡟㛵ࡋ㸪⮬ᕫⅬ᳨࣭ホ౯ࢆ⾜ࢃ࡞ࡅࢀࡤ
࡞ࡽ࡞࠸ࠋ
2ጤဨ఍ࡣ㸪ື≀ᐇ㦂➼ࡢᐇ᪋≧ἣ➼࡟㛵ࡍࡿ⮬ᕫⅬ᳨࣭ホ౯ࢆ⾜࠸㸪ࡑࡢ⤖ᯝࢆᏛ㛗࡟ሗ࿌ࡋ࡞
ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

3ጤဨ఍ࡣ㸪⟶⌮⪅㸪ື≀ᐇ㦂ᐇ᪋⪅㸪ື≀ᐇ㦂㈐௵⪅㸪ᐇ㦂ື≀⟶⌮⪅୪ࡧ࡟㣫㣴⪅➼࡟㸪⮬ᕫⅬ᳨࣭ホ౯ࡢࡓࡵࡢ㈨ᩱࢆᥦฟࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

4Ꮫ㛗ࡣ㸪⮬ᕫⅬ᳨࣭ホ౯ࡢ⤖ᯝ࡟ࡘ࠸࡚㸪Ꮫእࡢ⪅࡟ࡼࡿ᳨ドࢆཷࡅࡿࡼ࠺ດࡵࡿࡶࡢ࡜ࡍࡿࠋ
㸦᝟ሗࡢබ㛤㸧

➨ 36 ᮲ ᮏᏛ࡟࠾ࡅࡿ㸪ື≀ᐇ㦂➼࡟㛵ࡍࡿ᝟ሗ㸦ࡇࡢつ⛬㸪ᐇ㦂ື≀ࡢ㣫㣴ཪࡣಖ⟶ࡢ≧ἣ㸪⮬ᕫⅬ᳨࣭ホ౯㸪᳨ドࡢ⤖ᯝ㸪ື≀ᐇ㦂ጤဨ఍ࡢᵓᡂ➼ࡢ᝟ሗ㸧ࢆẖᖺ 1 ᅇ⛬ᗘ㸪࢖ࣥࢱ࣮ࢿࢵࢺࡢ
฼⏝ࡑࡢ௚ࡢ㐺ษ࡞᪉ἲ࡟ࡼࡾබ⾲ࡍࡿࠋ㸦‽⏝㸧
➨ 37 ᮲ ➨ 2 ᮲➨ 4 ྕ࡟ᐃࡵࡿᐇ㦂ື≀௨እࡢື≀ࢆ౑⏝ࡍࡿື≀ᐇ㦂➼࡟ࡘ࠸࡚ࡣ㸪㣫㣴ಖ⟶ᇶ‽ࡢ㊃᪨࡟ἢࡗ࡚⾜࡞࠺ࡼ࠺ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦㐺⏝㝖እ㸧
➨ 38 ᮲ ␆⏘࡟㛵ࡍࡿ㣫㣴⟶⌮ࡢᩍ⫱ⱝࡋࡃࡣヨ㦂◊✲ཪࡣ␆⏘࡟㛵ࡍࡿ⫱✀ᨵⰋࢆ┠ⓗ࡜ࡋࡓᐇ㦂ື≀㸦୍⯡࡟㸪⏘ᴗ⏝ᐙ␆࡜ぢ࡞ࡉࢀࡿື≀✀࡟㝈ࡿࠋ㸧ࡢ㣫㣴ཪࡣಖ⟶ཬࡧ⏕ែࡢほᐹࢆ⾜࠺ࡇ࡜ࢆ┠ⓗ࡜ࡋࡓᐇ㦂ື≀ࡢ㣫㣴ཪࡣಖ⟶࡟ࡘ࠸࡚ࡣ㸪ࡇࡢつ⛬ࢆ㐺⏝ࡋ࡞࠸ࠋࡇࡢሙྜ࡟࠾࠸
࡚㸪␆⏘ື≀࡟ࡘ࠸࡚ࡣ㸪⏘ᴗື≀ࡢ㣫㣴ཬࡧಖ⟶࡟㛵ࡍࡿᇶ‽㸦᫛࿴ 62 ᖺ⥲⌮ᗓ࿌♧➨ 22ྕ㸧㸪⏕ែࡢほᐹ࡟ࡘ࠸࡚ࡣ㸪ᐙᗞື≀➼ࡢ㣫㣴ཬࡧಖ⟶࡟㛵ࡍࡿᇶ‽㸦ᖹᡂ 14 ᖺ⎔ቃ┬࿌♧➨37 ྕ㸧࡟‽ࡌ࡚⾜࠺ࡶࡢ࡜ࡍࡿࠋ
2 ๓㡯ࡢつᐃ࡟࠿࠿ࢃࡽࡎ㸪እ⛉ⓗᥐ⨨ࢆ᪋ࡋ࡚◊✲ࢆ⾜࠺ሙྜ㸪⸆⌮Ꮫᐇ㦂࡟ࡼࡿ◊✲ࢆ⾜࠺ሙྜ୪ࡧ࡟ゎ๗Ꮫ㸪⏕⌮Ꮫ㸪⑓⌮Ꮫ➼ࡢᇶ♏⛉Ꮫཬࡧᛂ⏝⋇་Ꮫ㸪⮫ᗋ⋇་Ꮫ➼ࡢᩍ⫱ཬࡧᐇ⩦࡟౪ࡍࡿሙྜ࡟ࡣ㸪ࡇࡢつ⛬ࡢ㐺⏝ࢆཷࡅࡿࡶࡢ࡜ࡍࡿࠋ
㸦㞧๎㸧➨ 39 ᮲ ࡇࡢつ⛬࡟ᐃࡵࡿࡶࡢࡢ࡯࠿㸪ື≀ᐇ㦂࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ู࡟ᐃࡵࡿࠋ
㝃๎

1 ࡇࡢつ⛬ࡣ㸪ᖹᡂ 20 ᖺ 3 ᭶ 11 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ



2

ᒱ㜧኱Ꮫື≀ᐇ㦂つ⛬㸦ᖹᡂ 19 ᖺつ⛬➨ 57 ྕ㸧ཬࡧᒱ㜧኱Ꮫື≀ᐇ㦂ጤဨ఍⣽๎㸦ᖹᡂ 19 ᖺ⣽๎➨ 55 ྕ㸧ࡣ㸪ᗫṆࡍࡿࠋ㝃 ๎㸦ᖹᡂ 21 ᖺ 5 ᭶ 1 ᪥㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 21 ᖺ 5 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃 ๎㸦ᖹᡂ 22 ᖺ 4 ᭶ 1 ᪥㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 22 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎㸦ᖹᡂ 23 ᖺ 4 ᭶ 1 ᪥㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 23 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃 ๎㸦ᖹᡂ 24 ᖺ 8 ᭶ 1 ᪥㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 24 ᖺ 8 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃 ๎㸦ᖹᡂ 27 ᖺ 4 ᭶ 1 ᪥㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 27 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎㸦ᖹᡂ 29 ᖺ 4 ᭶ 1 ᪥㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 29 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃 ๎㸦ᖹᡂ 29 ᖺ 6 ᭶ 21 ᪥㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 29 ᖺ 6 ᭶ 21 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃 ๎㸦ᖹᡂ 30 ᖺ 5 ᭶ 1 ᪥㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 30 ᖺ 5 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃 ๎㸦ᖹᡂ 31 ᖺ 4 ᭶ 1 ᪥ᒱ㜧኱Ꮫつ⛬➨ 27 ྕ㸧ࡇࡢつ⛬ࡣ㸪ᖹᡂ 31 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃 ๎㸦௧࿴ 2 ᖺ 4 ᭶ 1 ᪥ᒱ኱つ⛬➨ 40 ྕ㸧ࡇࡢつ⛬ࡣ㸪௧࿴ 2 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎㸦௧࿴ 2 ᖺ 5 ᭶ 8 ᪥ᒱ኱つ⛬➨ 99 ྕ㸧ࡇࡢつ⛬ࡣ㸪௧࿴ 2 ᖺ 5 ᭶ 8 ᪥࠿ࡽ᪋⾜ࡋ㸪௧࿴ 2 ᖺ 4 ᭶ 1 ᪥࠿ࡽ㐺⏝ࡍࡿࠋ

4. άືሗ࿌
4-1. ฼⏝≧ἣ ື≀ᐇ㦂᪋タ฼⏝⪅≧ἣ㸦฼⏝⪅ᩘ㸧
ᖺ㛫ᘏ࡭฼⏝⪅ᩘⓏ㘓฼⏝⪅ᩘ

5 㝵 SPF ᑠື≀༊⏬

5,081

502

4 㝵ᑠື≀༊⏬

14,605676

3 㝵୰ື≀༊⏬

6,012

676

3 㝵 P2 ឤᰁᐇ㦂ᐊ

1,723

192

3 㝵 P3 ឤᰁᐇ㦂ᐊ

218

13

⥲ィ

27,639676ဵ ᖺ㛫ᘏ࡭฼⏝⪅ᩘ㸸ධ㏥ฟ࣮࢝ࢻࢩࢫࢸ࣒࡟࡚࢝࢘ࣥࢺࡋࡓධ㏥ฟ⪅ᩘ㸦᪋タ⟶⌮࣭⥔ᣢࢫࢱࢵࣇධ㏥ฟᩘࡣ㝖࠸࡚࠶ࡿ㸧ဵ Ⓩ㘓฼⏝⪅ᩘ㸸ධ㏥ฟ࣮࢝ࢻࡢⓎ⾜ᩘࠋ」ᩘࡢ༊⏬ࡢධ㏥ฟࡀྍ⬟࡞฼⏝⪅ࡀ࠸ࡿࡓࡵࠊ⥲ィࡣⓎ⾜࣮࢝ࢻᩘ㸦Ⓩ㘓฼⏝⪅ᩘෆヂ㸧㒊ᒁⓏ㘓฼⏝⪅ᩘ

Ⓩ㘓ࢢ࣮ࣝࣉᩘ

་Ꮫ㒊࣭⑓㝔

388

44ᛂ⏝⏕≀⛉Ꮫ㒊

80

21

ᕤᏛ㒊

15

1

ᩍ⫱Ꮫ㒊

2

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4-3. ᴗ⦼ㄽᩥ㞟ື≀ᐇ㦂᪋タ฼⏝⪅ᴗ⦼ㄽᩥ㸦2021
 ᖺⓎ⾲ศ㸧㸦㡰୙ྠ㸧㸦␎ㄒ㸧་㸸኱Ꮫ㝔་Ꮫ◊✲⛉ࠊᛂ㸸ᛂ⏝⏕≀⛉Ꮫ㒊ࠊ㐃๰㸸኱Ꮫ㝔㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉ࠊ⢾㙐㸸⢾㙐⏕࿨ࢥ࢔◊✲ᡤࠊ⛉ᇶࢭ㸸⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࠊ⸆኱㸸ᒱ㜧⸆⛉኱Ꮫ[་㸸ゎ๗Ꮫ]㹙1㹛 Li C, Onouchi T, Hirayama M, Sakai K, Matsuda S, Yamada NO, Senda T, Morphological andfunctional abnormalities of hippocampus in APC1638T/1638T mice, Med Mol Morphol, 54(1):31-40,
2021
㹙2㹛 Wenduerma, Yamada NO, Wang T, Senda T, A further study on a disturbance of intestinal
epithelial cell population and kinetics in APC1638T mice, Med Mol Morphol, 54(3):203-215, 2021
㹙3㹛 Hatakeyama S, Tojo A, Satonaka H, Yamada NO, Senda T, Ishimitsu T, Decreased Podocyte
Vesicle Transcytosis and Albuminuria in APC C-Terminal Deficiency Mice with Puromycin-Induced
Nephrotic Syndrome, Int J Mol Sci, 22(24):13412, 2021[་㸸ᐤ⏕⹸Ꮫ࣭ឤᰁᏛ]ʨ4ʩ Qingming Kong 1, Xunhui Zhuo 1, Xiaodi Yang 2, Haojie Ding 1, Jianzu Ding 1, Di Lou 1, Qunbo
Tong 1, Zhiliang Wu 3, Shaohong Lu 1, Early Detection of Trichinella spiralis DNA in Rat Feces
Based on Tracing Phosphate Ions Generated During Loop-Mediated Isothermal Amplification, J
Parasitol, 107,pp141-146, 10.1645/19-137
ʨ5ʩ Atchara Artchayasawat 1 2, Parichart Boueroy 3, Thidarut Boonmars 1 2, Benjamabhorn
Pumhirunroj 4, Pranee Sriraj 5, Ratchadawan Aukkanimart 5, Sirintip Boonjaraspinyo 6, Opal
Pitaksakulrat 1, Panaratana Ratanasuwan 7, Apiporn Suwannatrai 1 2, Chatanun Eamudomkarn
1 2, Porntip Laummaunwai 1, Wu Zhiliang 8, Efficacy of Dipterocarpus alatus oil combination with
Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis, Vet
World, 14,pp2919-2928, 10.14202/vetworld.2021.2919-2928
ʨ 6 ʩ Zhiliang Wu, Isao Nagano, Sukhonthip Khueangchiangkhwang and Yoichi Maekawa,
Trichinella and Trichinelosis-- Proteomics of Trichinella, London, Academic Press,pp103-184[་㸸ᩆᛴ࣭⅏ᐖ]ʨ7ʩ Endothelial Glycocalyx Disorders May Be Associated With Extended Inflammation During
Endotoxemia in a Diabetic Mouse Model; Sampei S, Okada H, Tomita H, Takada C, Suzuki K,
Kinoshita , Kobayashi R, Fukuda H, Kawasaki Y, Nishio A, Yano H, Muraki I, Fukuda Y, Suzuki K,
Miyazaki N, Watanabe T, Doi T, Yoshida T, Suzuki A, Yoshida S, Kushimoto S , Ogura S; frontiersin cell and developmental biology, 9, Article number 623582, 2021
ʨ8ʩ Recombinant antithrombin attenuates acute respiratory distress syndrome in experimental
endotoxemia; Okamoto H, Muraki I, Okada H, Tomita H, Suzuki K, Takada C, Wakayama Y,
Kuroda A, Fukuda H, Kawasaki Y, Nishio A, Matsuo M, Tamaoki Y, Inagawa R, Takashima S,
Taniguchi T, Suzuki A, Suzuki K, Miyazaki N, Kakino Y, Yasuda R, Fukuta T, Kitagawa Y, Miyake
T, Doi T, Yoshida T, Yoshida S, Ogura S; The American Journal of Pathology 191(9), 1526-1536, 2021
ʨ9ʩ≉㞟 จᅛ࡜⅖⑕ࡢࢫࢺ࣮ࣟࢡ ឤᰁ⑕㸦ᩋ⾑⑕ᛶ㸧⮚ჾ㞀ᐖ࡜ࢢࣜࢥ࢝ࣜࢵࢡࢫ; 囊ᮧ⤋ᕼࠊᒸ⏣ⱥᚿ; Br ICU ࡜ CCU, 45(6), 329-339, 2021

[་㸸⭘⒆⑓⌮Ꮫ]
ʨ10ʩ Kinoshita T, Tomita H, Okada H, Niwa A, Hyodo F, Kanayama T, Matsuo M, Imaizumi Y,
Kuroda T, Hatano Y, Miyai M, Egashira Y, Enomoto Y, Nakayama N, Sugie S, Matsumoto K,
Yamaguchi Y, Matsuo M, Hara H, Iwama T, Hara A. Endothelial cell-specific reduction of heparansulfate suppresses glioma growth in mice. Discov Oncol 2021; 12: 50.12.
ʨ11ʩ Miyai M, Kanayama T, Hyodo F, Kinoshita T, Ishihara T, Okada H, Suzuki H, Takashima S,
Wu Z, Hatano Y, Egashira Y, Enomoto Y, Nakayama N, Soeda A, Yano H, Hirata A, Niwa M, Sugie
S, Mori T, Maekawa Y, Iwama T, Matsuo M, Hara A, Tomita H. Glucose transporter Glut1 controls
diffuse invasion phenotype with perineuronal satellitosis in diffuse glioma microenvironment.
Neurooncol Adv 2021; 3: vdaa150.
ʨ12ʩ Mogi K, Yoshihara M, Iyoshi S, Kitami K, Uno K, Tano S, Koya Y, Sugiyama M, Yamakita Y,
Nawa A, Tomita H, Kajiyama H. Ovarian Cancer-Associated Mesothelial Cells: Transdifferentiation
to Minions of Cancer and Orchestrate Developing Peritoneal Dissemination. Cancers (Basel) 2021;13.
ʨ13ʩ Tomita H, Tanaka K, Hirata A, Okada H, Imai H, Shirakami Y, Ohnishi K, Sugie S, Aoki H,
Hatano Y, Noguchi K, Kanayama T, Niwa A, Suzui N, Miyazaki T, Tanaka T, Akiyama H, Shimizu
M, Yoshida K, Hara A. Inhibition of FGF10-ERK signal activation suppresses intraductal papillaryneoplasm of the bile duct and its associated carcinomas. Cell Rep 2021; 34: 108772.

[་㸸ᾘ໬ჾෆ⛉]ʨ14ʩ Shirakami Y, Nakanishi T, Ozawa N, Ideta T, Kochi T, Kubota M, Sakai H, Ibuka T, Tanaka
T, Shimizu M. Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on
inflammation-related colon tumorigenesis in APC-mutant rats. PLoS One 2021;16:e0251942.
ʨ15ʩ Miyazaki T, Shirakami Y, Mizutani T, Maruta A, Ideta T, Kubota M, Sakai H, Ibuka T,
Genovese S, Fiorito S, Taddeo VA, Epifano F, Tanaka T, Shimizu M. Novel FXR agonist nelumal A
suppresses colitis and inflammation-related colorectal carcinogenesis. Sci Rep 2021;11:492.
ʨ16ʩ Ichikawa H, Suetsugu A, Satake T, Aoki H, Kunisada T, Shimizu M, Robert M. Hoffman.
Exosome Transfer between pancreatic-cancer cells is associated with metastasis in a nude-mousemodel. Anticancer Res 2021;41:2829-2834.
ʨ17ʩ Ito D, Ito H, Ideta T, Kanbe A, Ninomiya S, Shimizu M. Systemic and topical administrationof spermidine accelerates skin wound healing. Cell Commun Signal 2021;19:36[་㸸ᩚᙧእ⛉Ꮫ]
ʨ18ʩ Takeuchi K, Ogawa H, Kuramitsu N, Akaike K, Goto A, Aoki H, Lassar A, Suehara Y, Hara A,
Matsumoto K, Akiyama H. Colchicine protects against cartilage degeneration by inhibiting MMP13
expression via PLC-ǄSKRVSKRU\ODWLRQ2VWHRDUWKULWLVDQG&DUWLODJH1RY  -1574.

[་㸸⏕࿨ᶵ⬟ศᏊタィ]ʨ 19 ʩ Takahashi T., Shiraishi A., Murata J., Matsubara S., Nakaoka S., Kirimoto S., Osawa
M.(2021),Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrinB signaling, Life Science Alliance 4e202000962[་㸸෌⏕ᶵ⬟་Ꮫ]
ʨ20ʩ Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of thevagal nerve. Aoki H, Abe C, Hara A, Miyazaki T, Morita H, Kunisada T. Genes Cells. 2021
Feb;26(2):45-55. doi: 10.1111/gtc.12819. Epub 2021 Jan 13.PMID: 33211397 SciSCO:3.1
ʨ21ʩ Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of thebile duct and its associated carcinomas. Tomita H, Tanaka K, Hirata A, Okada H, Imai H,Shirakami Y, Ohnishi K, Sugie S, Aoki H, Hatano Y, Noguchi K, Kanayama T, Niwa A, Suzui N,
Miyazaki T, Tanaka T, Akiyama H, Shimizu M, Yoshida K, Hara A. Cell Rep. 2021 Feb
23;34(8):108772. doi: 10.1016/j.celrep.2021.108772.PMID: 33626352 SciSCO:13.6
ʨ22ʩ Exosome Transfer Between Pancreatic-cancer Cells Is Associated With Metastasis in a Nudemouse Model. Ichikawa H, Suetsugu A, Satake T, Aoki H, Kunisada T, Shimizu M, Hoffman RM.
Anticancer Res. 2021 Jun;41(6):2829-2834. doi: 10.21873/anticanres.15063. SciSCO:3.8
ʨ23ʩ Colchicine protects against cartilage degeneration by inhibiting MMP13 expression via PLCȚ1 phosphorylation. Takeuchi K, Ogawa H, Kuramitsu N, Akaike K, Goto A, Aoki H, Lassar A,
Suehara Y, Hara A, Matsumoto K, Akiyama H. Osteoarthritis Cartilage. 2021 Nov;29(11):15641574. doi: 10.1016/j.joca.2021.08.001. Epub 2021 Aug 20. SciSCO:9.0[་㸸⬻⚄⤒እ⛉]
ʨ24ʩ Sampei S, Okada H, Tomita H, Takada C, Suzuki K, Kinoshita T, Kobayashi R, Fukuda H,
Kawasaki Y, Nishio A, Yano H, Muraki I, Fukuda Y, Suzuki K, Miyazaki N, Watanabe T, Doi T,
Yoshida T, Suzuki A, Yoshida S, Kushimoto S, Ogura S : Endothelial Glycocalyx Disorders May Be
Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model. Front
Cell Dev Biol. 2021; 9: 623582.
ʨ25ʩ Kinoshita T, Tomita H, Okada H, Niwa A, Hyodo F, Kanayama T, Matsuo M, Imaizumi Y,
Kuroda T, Hatano Y, Miyai M, Egashira Y, Enomoto Y, Nakayama N, Sugie S, Matsumoto K,
Yamaguchi Y, Matsuo M, Hara H, Iwama T, Hara AʁEndothelial cell-specific reduction of heparansulfate suppresses glioma growth in mice. Discov Oncol. volume 12, Article number: 50 (2021)[་㸸⮫ᗋ᳨ᰝ་Ꮫ]ʨ26ʩ Ito D, Ito H, Ideta T, Kanbe A, Ninomiya S, Shimizu M. Systemic and topical administrationof spermidine accelerates skin wound healing. Cell Commun Signal. 2021 Mar 22;19(1):36.

[㐃๰㸸⏕࿨ศᏊ⛉Ꮫ◊✲㡿ᇦ]
ʨ27ʩ Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor
growth and metastasis. Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y,
Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y.J Clin Invest. 2021 Sep 1;131(17):e139933. doi:
10.1172/ JCI139933.

ʨ28ʩ Teiko K Nomura, Kazuki Heishima, Nobuhiko Sugito, Ryota Sugawara, Hiroshi Ueda, Akao
Yukihiro, and *Ryo Honda: Specific inhibition of oncogenic RAS using cell-permeable RAS-binding
domains, Cell Chemical Biology 28(18), 1581-1589, 2021 (IF 8.12, CiteScore 12.9)[⢾㙐㸸⢾㙐ไᚚศ㔝]ʨ29ʩ Kawade H., Morise J., Mishra S.K., Tsujioka S., Oka S., Kizuka Y. (2021) Tissue-specificregulation

of

HNK-1

biosynthesisbybisecting

GlcNAc.

Molecules,

26,

5176.

doi:

10.3390/molecules26175176.
ʨ30ʩ #Ohkawa Y., #Kizuka Y., Takata M., Ito E., Mishra S.K., Akatsuka H., Harada Y., Taniguchi N.
(2021) Peptide sequence mapping around bisecting GlcNAc-bearing N-glycans in mouse brain. Int.
J. Mol. Sci., 22, 8579. doi: 10.3390/ijms22168579. #equal contribution[⛉ᇶࢭ㸸ᢠ㓟໬◊✲㒊㛛]
ʨ31ʩ ≟ᡣ᫓ᙪ. ✲ᴟࡢ࢔ࣥࢳ࢚࢖ࢪࣥࢢ. බ┈㈈ᅋἲே ῰ἑᰤ୍グᛕ㈈ᅋࠕ㟷ῡࠖ➨ 863 ྕ 2 ᭶ྕ,
2021 ᖺ 2 ᭶Ⓨ⾜.

[⸆኱㸸⾨⏕Ꮫ]ʨ32ʩ Ma H, Ishida K, Xu C, Takahashi K, Li Y, Zhang C, Kang Q, Jia Y, Hu W, Matsumaru D,
Nakanishi T, Hu J*, Triphenyl phosphate delayed pubertal timing and induced decline of ovarian
reserve in mice as an estrogen receptor antagonist. Environ. Pollut. 290. 118096 (2021)
ʨ34ʩ Shiraishi E, Ishida K, Matsumaru D, Ido A, Hiromori Y, Nagase H, Nakanishi T*, Evaluationof the skin-sensitizing potential of Brazilian green propolis. Int. J. Mol. Sci. 22, 13538 (2021).

[⸆኱㸸ឤᰁไᚚᏛ]ʨ 35 ʩ Intimate Adhesion Is Essential for the Pathogen-Specific Inflammatory and Immune
Responses in the Gut of Mice Infected with Citrobacter rodentium. Takahashi K, Sugiyama T,
Tokunoh N, Tsurumi S, Koshizuka T and Inoue N. Immuno Horizons 5(10)870-883 2021[⸆኱㸸⸆ຠゎᯒᏛ]
ʨ36ʩ Kinoshita T., Tomita H., Okada H., Niwa A., Hyodo F., Kanayama T., Matsuo M., Imaizumi Y.,
Kuroda T., Hatano Y., Miyai M., Egashira Y., Enomoto Y., Nakayama N., Sugie S., Matsumoto K.,
Yamaguchi Y., Matsuo M., Hara H., Iwama T. and Hara A. Endothelial cell-specific reduction of
heparan sulfate suppresses glioma growth in mice. Discover Oncology, 12:50 (2021).

ʨ37ʩ Takahashi K., Nakamura S., Shimazawa M. and Hara H. Retinal degeneration and microglial
dynamics in mature progranulin-deficient mice. International Journal of Molecular Sciences, 22,
21 (2021).
ʨ38ʩ Takahashi K., Nakamura S., Otsu W., Shimazawa M. and Hara H. Progranulin deficiency in
Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function
and abnormal inflammation. Journal of Neuroinflammation, 25;18(1):164 (2021).
ʨ39ʩ Tsuji S, Nakamura S, Yamada T, Susana de Vega, Okada Y, Inoue S, Shimazawa M and Hara
H. HYBID derived from tumor cells and tumor-associated macrophages contribute to glioblastoma
growth. Brain Research., 1764, 1 (2021)

4-4. ື≀ᐇ㦂ศ㔝ᩍဨࡢᩍ⫱࣭◊✲άື㸦ᩍ⫱㸧࣭኱Ꮫ㝔㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉࣭⏕࿨⛉Ꮫ࡜ື≀ឡㆤ㞟୰ㅮ⩏㸦㸯༢఩ࠊ๓ᮇ㸧㸦஧ୖ㸧࣭ᛂ⏝⏕≀⛉Ꮫ㒊࣭ᐇ㦂ື≀Ꮫㅮ⩏㸦㸰༢఩ࠊ㑅ᢥ⛉┠ࠊ⏕⏘⎔ቃᏛㄢ⛬㸱ᖺᚋᮇ㸧㸦஧ୖ㸧࣭ᐇ㦂ື≀Ꮫᐇ⩦㸦㸯༢఩ࠊ⋇་Ꮫㄢ⛬㸱ᖺ๓ᮇࠊศᢸ㸧㸦஧ୖࠊᇼ஭㸧࣭ᐇ㦂ື≀Ꮫᐇ⩦㸦㸯༢఩ࠊ⋇་Ꮫㄢ⛬㸰ᖺᚋᮇࠊศᢸ㸧㸦஧ୖࠊᇼ஭㸧࣭ඛ➃ᇶ♏⋇་Ꮫ≉ูㅮ⩏㸦1 ༢఩ࠊ㑅ᢥ⛉┠ࠊ⋇་Ꮫㄢ⛬㸳ᖺᚋᮇࠊศᢸ㸧㸦ᇼ஭㸧
㸦ㄽᩥ㸧
[ⱥᩥ]
1.

Horii Y, Okadera K, Miyawaki S, Shiina T, Shimizu Y. Suncus murinus as a novel model animal that is suitablefor elucidating the mechanism of daily torpor. Biomed Res. 43(2):53-57, 2022.

㸦ᅜෆᏛ఍㸧
1. ᇼ஭᭷ᕼࠊⓑ▼ⱱ⳯ᐇࠊ᳝ྡ㈗ᙪࠊᚿỈὈṊࠊ෤╀ᵝ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢࡢኚ໬࡟࠾ࡅࡿ Coldinducible RNA-binding protein ㌿෗≀ࡢᐃ㔞ⓗゎᯒࠊ➨ 164 ᅇ᪥ᮏ⋇་Ꮫ఍Ꮫ⾡㞟఍ࠊ2021 ᖺ 9 ᭶
2. ⓑ▼ⱱ⳯ᐇࠊᇼ஭᭷ᕼࠊ᳝ྡ㈗ᙪࠊᚿỈὈṊࠊ࣐࢘ࢫࡢ᪥ෆఇ╀᫬࡟࠾ࡅࡿ Cold-inducible RNA-binding
protein 㑇ఏᏊࡢ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢࡢኚ໬ࠊ➨ 164 ᅇ᪥ᮏ⋇་Ꮫ఍Ꮫ⾡㞟఍ࠊ2021 ᖺ 9 ᭶
3. ⓑ▼ⱱ⳯ᐇࠊᇼ஭᭷ᕼࠊ᳝ྡ㈗ᙪࠊᚿỈὈṊࠊ᪥ෆఇ╀࡟ࡼࡾᘬࡁ㉳ࡇࡉࢀࡿ Cold-inducible RNAbinding protein 㑇ఏᏊࡢ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢࡢ෤╀ᵝኚ໬ࠊ➨ 68 ᅇ୰㒊᪥ᮏ⏕⌮Ꮫ఍ࠊ2022 ᖺ 10
᭶4. ᇼ஭᭷ᕼࠊⓑ▼ⱱ⳯ᐇࠊ᳝ྡ㈗ᙪࠊᚿỈὈṊࠊ෤╀ᵝ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢ࡟ࡼࡿ Cold-inducible RNAbinding protein ㌿෗≀ࡢⓎ⌧㔞ࡢኚ໬ࠊ➨ 68 ᅇ୰㒊᪥ᮏ⏕⌮Ꮫ఍ࠊ2022 ᖺ 10 ᭶
5. ᇼ஭᭷ᕼࠊⓑ▼ⱱ⳯ᐇࠊ᳝ྡ㈗ᙪࠊᚿỈὈṊࠊCold-inducible RNA-binding protein ࡟࠾ࡅࡿ෤╀ᵝ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢࡢኚ໬࡟࠾ࡅࡿ㌿෗≀ࡢᐃ㔞ⓗゎᯒࠊ➨ 99 ᅇ᪥ᮏ⏕⌮Ꮫ఍኱఍ࠊ2022 ᖺ 3 ᭶㸦⿵ຓ㔠㛵㐃᥇ᢥ≧ἣ㸧㸯㸬௧࿴ 3Ѹ5 ᖺᗘ ᅜ❧◊✲㛤Ⓨἲே ⛉Ꮫᢏ⾡᣺⯆ᶵᵓ ᡓ␎ⓗ๰㐀◊✲᥎㐍஦ᴗ㸦ACT-X㸧ࠕ⏕࿨࡜໬Ꮫࠖ㡿ᇦ ࠕ෤╀ᵝ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢᶵᵓࡢᛂ⏝ἲࡢ㛤Ⓨࠖ◊✲௦⾲⪅㸦ᇼ஭㸧㸰㸬௧࿴ 3Ѹ5 ᖺᗘ බ┈㈈ᅋἲே ෆ⸨グᛕ⛉Ꮫ᣺⯆㈈ᅋ ෆ⸨グᛕዪᛶ◊✲⪅◊✲ຓᡂ㔠ࠕప ࢩࣙࢵࢡࢱࣥࣃࢡ㉁ࡢ෤╀ᵝⓎ⌧࡟ࡼࡿയᐖ⪏ᛶᶵᵓࡢゎ᫂࡜ᛂ⏝࡟㛵ࡍࡿ◊✲ࠖ◊✲௦⾲⪅㸦ᇼ஭㸧㸦఍㆟㸧࣭➨ 47 ᅇ ᅜ❧኱Ꮫἲேື≀ᐇ㦂᪋タ༠㆟఍⥲఍㸸2021 ᖺ 6 ᭶ 11 ᪥ࠊ୺ദᰯ㸸ዉⰋඛ➃⛉Ꮫᢏ⾡኱Ꮫࠊ఍ሙ㸸࣮ࣜࣔࢺࠊศ㔝㛗஧ୖⱥᶞࠊᇼ஭᭷ᕼࠊ኱ᒣ㈗அࠊ௒ᗘ໷♸ฟᖍ㸦♫఍άື㸧
࣭ᅜ❧኱Ꮫἲேື≀ᐇ㦂᪋タ༠㆟఍ㄪᰝጤဨ఍ጤဨ㸦஧ୖ㸧࣭ᅜ❧኱Ꮫἲேື≀ᐇ㦂᪋タ༠㆟఍Ꮫ⾡᝟ሗ࣭ᗈሗጤဨ఍ጤဨ㸦஧ୖ㸧࣭ᅜ❧኱Ꮫἲேື≀ᐇ㦂᪋タ༠㆟఍ື≀ᐇ㦂㐺ṇ໬ጤဨ఍ጤဨ㸦஧ୖ㸧࣭᪥ᮏᐇ㦂ື≀Ꮫ఍ホ㆟ဨ㸦஧ୖ㸧࣭᪥ᮏᐇ㦂ື≀་Ꮫ఍ᐇ㦂ື≀ἲつ➼᳨ウጤဨ఍ጤဨ㸦஧ୖ㸧࣭ᮾᾏᐇ㦂ື≀◊✲఍ ఍㛗ࠊ஦ົᒁ㸦஧ୖ㸧ᶵჾศᯒศ㔝
Division of Instrumental Analysis
ࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : kiki@gifu-u.ac.jp
TEL : 058-293-2035
FAX : 058-293-2036

┠࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫ ی‬ศ㔝㛗௦⾜ᣵᣜ
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 ἢ㠉
 ᶵჾศᯒศ㔝⫋ဨ ༠ຊဨ࠾ࡼࡧ༠ຊ⿵ຓဨ
ᶵჾศᯒศ㔝༠ຊဨ࡟㛵ࡍࡿ⏦ࡋྜࢃࡏ⾲  ༠ຊဨྡ⡙2 ᶵჾ⤂௓

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ᶵჾ୍ぴ࠙ᰗᡞᆅ༊ࠚ⾲ ࠊ࠙་Ꮫᆅ༊ࠚ⾲ ᶵჾ㓄⨨ሙᡤ࠙ᰗᡞᆅ༊ࠚ⾲ ࠊ࠙་Ꮫᆅ༊ࠚ⾲

ඹ⏝ᶵჾࡢᴫせ࠙ᰗᡞᆅ༊ࠚ
ࠊ࠙་Ꮫᆅ༊ࠚ
3 ฼⏝ࡢᡭᘬࡁ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ᶵჾศᯒศ㔝฼⏝ࡢᡭ㡰 ィ ᶵჾࡢ฼⏝࡟㛵ࡍࡿ⏦ࡋྜࢃࡏู⾲  ฼⏝⪅㈨᱁࠙ᰗᡞᆅ༊ࠚ
ࠊ࠙་Ꮫᆅ༊ࠚู⾲  ᶵჾศᯒศ㔝฼⏝⏦ㄳ᭩ู⾲  ᫬㛫እ฼⏝ᒆ㸦ᰗᡞᆅ༊㸧ࠊ㸦་Ꮫᆅ༊㸧 ཷクヨ㦂࡟ࡘ࠸࡚㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝 ཷクヨ㦂㸪 ᐃཬࡧ᳨ᰝ➼ྲྀᢅせ㡯ู⾲ ヨ㦂➼ࡢᇶᮏ฼⏝ᩱ㔠 ཷクヨ㦂➼ࡢᡭ⥆ࡁู⣬ᵝᘧ➨  ྕ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ཷクヨ㦂౫㢗᭩ู⣬ᵝᘧ➨  ྕ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾ➼౑⏝⏦ㄳ᭩
4 άືሗ࿌

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭   ᖺᗘᶵჾࡢ฼⏝≧ἣ
Ⓩ㘓ேᩘࠊᘏ฼⏝ேᩘࠊᘏ᳨యᩘࠊᘏ౑⏝᫬㛫࠙ᰗᡞᆅ༊ࠚ⾲ ࠊ
࠙་Ꮫᆅ༊ࠚ⾲  άື≧ἣሗ࿌  ᖺᗘᶵჾศᯒศ㔝༠ຊဨ఍㆟  ᖺᗘᅜ❧኱Ꮫᶵჾ࣭ศᯒࢭࣥࢱ࣮༠㆟఍  ྛ✀ㅮ⩦఍ཬࡧࢭ࣑ࢼ࣮  ᶵჾศᯒศ㔝ཷクヨ㦂➼౫㢗ᐇ⦼  ࢭࣥࢱ࣮ぢᏛ  ᶵჾศᯒศ㔝ᶵ㛵ㄅࡢཎ✏సᡂ➼ ฼⏝⪅◊✲ㄽᩥ୍ぴ ᶵჾศᯒศ㔝ᩍဨࡢᩍ⫱࣭◊✲άື➼‫ ی‬ศ㔝㛗௦⾜ᣵᣜᶵჾศᯒศ㔝㛗௦⾜ 㙊㊊㞝ྖᏛෆእࡢ◊✲⪅ࡢⓙᵝ࡟ࡣ᪥㡭ࡼࡾᶵჾศᯒศ㔝ࡢ◊✲ᇶ┙ࠊཷクヨ㦂ࢆ฼⏝㡬ࡁ࠶ࡾࡀ࡜࠺ࡈࡊ
࠸ࡲࡍࠋᶵჾศᯒศ㔝ࡣࠊ⛉Ꮫ◊✲ࡢᇶ┙ࢆᨭ࠼ࡿࢭࣥࢱ࣮ࡢ୍ศ㔝࡜ࡋ࡚ࠊ㟁Ꮚ㢧ᚤ㙾ࠊ᰾☢Ẽඹ㬆ศග⿦⨨ (NMR)ࠊ㉁㔞ศᯒ⿦⨨࡞࡝ࡢ኱Ꮫࡢ◊✲ຊࢆᨭ࠼ࡿ኱ᆺࡢྛ✀ ᐃᶵჾ࡜ ᐃᢏ⾡ࢆ◊✲⪅࡟ᥦ౪ࡍࡿࡇ࡜࡛ࠊ◊✲࡜ᩍ⫱࡟㈉⊩ࡋࠊᮾᾏᅜ❧኱Ꮫᶵᵓࡢ୰ᮇ┠ᶆ࡛࠶ࡿࠕᅜ㝿ⓗ࡞➇தຊྥୖ࡜ᆅ
ᇦ๰⏕࡬ࡢ㈉⊩ࢆ୧㍯࡜ࡋࡓⓎᒎࠖ㐩ᡂࢆ┠ᣦࡋ࡚࠸ࡲࡍࠋࡲࡓࠊᏛእྥࡅࡢཷクヨ㦂ࡸබ㛤ࢭ࣑ࢼ
࣮ࢆ㏻ࡌ࡚ࠊ♫఍࡟㈉⊩ࡋ࡚࠸ࡲࡍࠋࡇࡇᩘᖺ╔ᐇ࡟ཷクヨ㦂ࡢ౫㢗ࡶቑ࠼ࠊ᫖ᖺᗘࡣ 106 ௳ࡢࡈ฼⏝ࢆ㡬ࡁࡲࡋࡓࠋ
ࡇࢀ࠿ࡽࡶࠊ฼⏝⪅ⓙᵝࡢ◊✲ࡢⓎᒎ࡟ᐤ୚࡛ࡁࡲࡍࡼ࠺ࠊ༠ຊဨࡢඛ⏕᪉ࡢࡈᨭ᥼ࢆ㈷ࡾ࡞ࡀ
ࡽࠊᙜศ㔝ࢆ㐠Ⴀࡋ࡚࠸ࡃᡤᏑ࡛ࡍࠋ௒ᚋ࡜ࡶ࡝࠺ࡒࡼࢁࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ



㸯

⤌⧊

1. ἢ㠉
᫛࿴ 55 ᖺᗘ ᒱ㜧኱Ꮫ⤫ྜ⛣㌿࡟క࠸ࠊᏛෆඹྠᒱ㜧኱Ꮫ᝟ሗ࣭ィ ࢭࣥࢱ࣮ࢆタ⨨ࠋ᫛࿴ 58 ᖺᗘ ᒱ㜧኱Ꮫィ ࢭࣥࢱ࣮ཬࡧᒱ㜧኱Ꮫ᝟ሗฎ⌮ࢭࣥࢱ࣮࡟ᨵ⤌ࠋ
ᖹᡂ 9 ᖺᗘ ┬௧໬࡟క࠸ࠊᒱ㜧኱Ꮫᶵჾศᯒࢭࣥࢱ࣮࡜ࡋ࡚᪂ࡓ࡟Ⓨ㊊ࠋ
ᖹᡂ 15 ᖺᗘ ࢭࣥࢱ࣮⤫ྜ࡟ࡼࡾ⏕࿨⛉Ꮫ⥲ྜᐇ㦂ࢭࣥࢱ࣮ᶵჾศᯒศ㔝࡟ᨵྡࠋᖹᡂ 16 ᖺᗘ ኱ᆺ⢭ᐦᶵჾ㧗ᗘ฼⏝බ㛤ࢭ࣑ࢼ࣮㛤ጞࠋᏛእྥࡅࡢཷクヨ㦂ไᗘࢆᩚഛࠋ
ᖹᡂ 17 ᖺᗘ ⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮࡬ྡ⛠ኚ᭦ࠋ
ᖹᡂ 23 ᖺᗘ ே⋇ឤᰁ㜵ᚚࢭࣥࢱ࣮࠿ࡽᶵჾ⛣⟶࡟ࡼࡾࠊ་Ꮫ᪋タࢆタ⨨ࠋᖹᡂ 26 ᖺᗘ ་Ꮫ᪋タࢆ⤫ྜࠋᖹᡂ 30 ᖺᗘ ◊✲᥎㐍࣭♫఍㐃ᦠᶵᵓࡢചୗ࡟ධࡾ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࡬ྡ⛠ኚ᭦ࠋ
௧࿴ 2 ᖺᗘ ᮾᾏᅜ❧኱ᏛᶵᵓࡢⓎ㊊࡟క࠸ࠊᒱ㜧኱Ꮫ㧗➼◊✲㝔࡟ᡤᒓࠋ௧࿴ 3 ᖺᗘ ⢾㙐⏕࿨ࢥ࢔◊✲ᡤ࡟ᡤᒓࠋ

2. ᶵჾศᯒศ㔝⫋ဨ㸦㸧ෆࡣෆ⥺␒ྕ

(1) ᑓ௵ᩍဨຓᩍ

㙊㊊ 㞝ྖ㸦3900㸧

(2) ⫋ဨ๪ᢏᖌἑ⏣ ⩏἞㸦2035㸧

ᢏ⾡⫋ဨ஧ࣀᐑ ┿அ㸦2035㸧

ᢏ⾡⿵బဨ⚄㇂ ဴ஧㸦2035㸧

ᢏ⾡⿵బဨ㧗ᑎ ⤱௦㸦2035㸧

3. ༠ຊဨ࠾ࡼࡧ༠ຊ⿵ຓဨ
ᶵჾศᯒศ㔝༠ຊဨ࡟㛵ࡍࡿ⏦ࡋྜࢃࡏ㸦㊃᪨㸧➨㸯᮲ ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㸦௨ୗࠕࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ
㸧࡟⨨ࡃᶵჾศᯒศ㔝༠ຊဨ㸦௨ୗࠕ༠ຊဨࠖ࡜࠸࠺ࠋ㸧࡟㛵ࡋࠊᚲせ࡞஦㡯ࢆᐃࡵࡿࠋ㸦ᐃ⩏㸧➨㸰᮲ ༠ຊဨࡣࠊࢭࣥࢱ࣮ࡢᶵჾศᯒศ㔝ࡀᡤ᭷ࡍࡿᶵჾཬࡧタഛ㸦௨ୗࠕᶵჾ➼ࠖ࡜࠸࠺ࠋ㸧ࢆࠊ㈐௵ࢆࡶࡗ࡚ྲྀᢅ࠺ࡇ࡜ࡀ࡛ࡁࡿ⪅࡜ࡍࡿࠋ㸦⤌⧊㸧➨㸱᮲ ༠ຊဨࡣࠊᶵჾࡈ࡜࡟⨨ࡁࠊࢭࣥࢱ࣮㛗ࡀ᥎⸀ࡍࡿᒱ㜧኱Ꮫࡢᑓ௵ࡢᩍဨࢆࡶࡗ࡚඘࡚ࠊᏛ
㛗ࡀጤკࡍࡿࠋ

㸦㈐௵⪅㸧➨㸲᮲ ༠ຊဨࡢ஫㑅࡟ࡼࡾᢸᙜࡍࡿᶵჾࡈ࡜ࡢ㈐௵⪅㸦௨ୗࠕ㈐௵⪅ࠖ࡜࠸࠺ࠋ
㸧ࢆ㑅ฟࡍࡿࠋ㸦௵ົ㸧➨㸳᮲ ༠ຊဨࡣࠊࢭࣥࢱ࣮ࡢᩍ⫋ဨ࡜༠ຊࡋ࡚ḟࡢෆᐜࢆ༠㆟ࡋࠊᴗົࢆ⾜࠺ࠋձᶵჾ➼ࡢཎ⌮࣭౑⏝ἲ࡟㛵ࡍࡿㅮ⩦఍➼࡟㛵ࡍࡿࡇ࡜ࠋ

ղᶵჾ➼ࡢ⥔ᣢ⟶⌮࡟㛵ࡍࡿࡇ࡜ࠋ

ճᶵჾ➼ࡢ౑⏝ἲ➼┦ㄯ࡟㛵ࡍࡿࡇ࡜ࠋ

մࡑࡢ௚ࠊᶵჾ➼ࡢ෇⁥࡞㐠⏝࡟㛵ࡍࡿࡇ࡜ࠋ㸦௵ᮇ㸧➨㸴᮲ ༠ຊဨࡢ௵ᮇࡣ஧ᖺ࡜ࡋࠊ෌௵ࢆጉࡆ࡞࠸ࠋ㸦⿵ຓဨ㸧➨㸵᮲ ༠ຊဨࡢᴗົࢆ⿵ຓࡍࡿࡓࡵ࡟ࠊ༠ຊဨ⿵ຓဨ㸦௨ୗࠕ⿵ຓဨࠖ࡜࠸࠺ࠋ
㸧ࢆ⨨ࡃࡇ࡜ࡀ࡛ࡁ
ࡿࠋ㸰⿵ຓဨࡣࠊ༠ຊဨࡢᴗົ࡬ࡢ⿵ຓࡀᚲせ࡞ᶵჾࡈ࡜࡟⨨ࡁࠊࢭࣥࢱ࣮㛗ࡀ᥎⸀ࡍࡿ⪅ࢆࡶࡗ࡚඘
࡚ࠊᏛ㛗ࡀጤკࡍࡿࠋ

㸱⿵ຓဨࡢ௵ᮇࡣ஧ᖺ࡜ࡋࠊ෌௵ࢆጉࡆ࡞࠸ࠋ⾲  ༠ຊဨྡ⡙ 㸦‫۔‬㸸ᶵჾྲྀᢅ㈐௵⪅ࠊ*㸸༠ຊ⿵ຓဨ㸧
ᶵ

ჾ

ྡ

Ặ

R2. 4. 1
ྡ

㟁ヰ␒ྕ

㝯
ᑗ
㇏
ಟ
ᆂྐ
Ꮫ
㐨அ
ὒᶞ
㕲ᖹ
㑣჆Ꮚ
ṇஅ*
೔Ꮚ*

2590
2639
2589
2574
2514
2588
2566
2957
2930
2869
2500
5531

㒊

ᒁ

࠙ᰗᡞᆅ༊ࠚ
኱ᆺ㟁Ꮚ㢧ᚤ㙾
㸦㏱㐣ᆺ H-7000 ᙧ࣭TEM࣭᪥❧㸧
㸦㏱㐣ᆺ JEM-2100 ᙧ࣭TEM࣭᪥ᮏ㟁ᏊࠊEDX㸧㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾
㸦S-3000N࣭SEM㸧㟁⏺ᨺฟᆺ㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾㸦S-4300࣭SEMࠊEDX㸧㧗ศゎ⬟㟁⏺ᨺฟᆺ㉮ᰝ㟁Ꮚ㢧ᚤ㙾㸦S-4800࣭SEMࠊEDX㸧
ࢹࢪࢱ࣐ࣝ࢖ࢡࣟࢫࢥ࣮ࣉ㸦ࣛ࢖࢝ DVM㸫5000㸧┿✵⵨╔⿦⨨
࢖࢜ࣥࢫࣃࢵࢱ࣭࢚࢔࣏࣮ࣞࢩࣙࣥࣘࢽࢵࢺ
㸦࣮࢝࣎ࣥᑓ⏝㸧ࢹ࢕ࣥࣉࣝࢢࣛ࢖ࣥࢲ࣮
࢞ࣛࢫࢼ࢖ࣇసᡂჾ
㉸࣑ࢡࣟษ∦స〇ࢩࢫࢸ࣒ࢿ࢜࢜ࢫ࣑࣒࢘ࢥ࣮ࢱ࣮
࢖࣑࢜ࣥࣜࣥࢢ
⢭ᐦ࢖࣏࢜ࣥࣜࢵࢩࣥࢢ⿦⨨ග◳໬ᛶᶞ⬡ໟᇙ⿦⨨



‫۔‬ᮡᾆ
ụ⏣
኱▮
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ෆ⸨
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຾㔝
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▮㔝

ᕤᏛ㒊
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ᛂ⏝⏕≀⛉Ꮫ㒊ࠌࠌᕤᏛ㒊ᛂ⏝⏕≀⛉Ꮫ㒊࠙ᰗᡞᆅ༊ࠚ
㉮ᰝᆺࣉ࣮ࣟࣈ㢧ᚤ㙾ࢩࢫࢸ࣒
㸦AFM5300E, AFM5400L㸧

࠙ᰗᡞᆅ༊ࠚ
㉮ᰝᆺ X ⥺ග㟁Ꮚศගศᯒ⿦⨨㸦Quantera SXM-GS㸧

‫۔‬Ṋ㔝
኱▮
኱࿴
す⏣
ෆ⸨
௒Ἠ

᫂⩏
㇏
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ဴ
ᆂྐ
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2629
2589
2682
2538
2514
2930

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ࠌ
ᛂ⏝⏕≀⛉Ꮫ㒊

‫۔‬㧗ᶫ
ୖᆏ
Ḉ⏣
す⏣
኱ᶫ
ᒣ⏣
㡲⥙

⤀▮
⿱அ
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2631
2511
2574
2538
2686
2819
2509

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୕༤
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୍ᗈ
ᩥ฼
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➗Ꮚ
㑣჆Ꮚ
ᜏ⏕
ಇᗣ

2251
2619
2561
2616
2645
2596
2914
2869
2897
3901

ᩍ⫱Ꮫ㒊
ᕤᏛ㒊
ࠌ
ࠌ
ࠌ
ࠌ
ᛂ⏝⏕≀⛉Ꮫ㒊
ࠌ
ࠌ

‫‶۔‬಴
ྜྷᯇ
⧴⧭
Ⱚཎ
ᑠᮧ
❑⏣
ᰗ℩
ᒣෆ
≟ሯ

ᾈ୍
୕༤
Ᏺ
ᩥ฼
㈼୍
⿱኱
➗Ꮚ
ᜏ⏕
ಇᗣ

2649
2251
2619
2616
2600
2596
2914
2897
3901

⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮

‫୕۔‬㍯
኱ᶫ
ᒣᐙ

ὒᖹ
ྐ㝯
ග⏨*

2565
2686
3902

ᕤᏛ㒊
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≉ู༠ຊ◊✲ဨ࠙ᰗᡞᆅ༊ࠚ‫ྜྷ۔‬ᯇ⧴⧭㧗ศゎ⬟㉁㔞ศᯒ⿦⨨᳜ᮧ
㸦GCmate II, JMS-700, AMSUN200,JMS-T100LP, AXIMA㸧Ⱚཎᾮయࢡ࣐ࣟࢺࢢࣛࣇ
኱㔝
㸦Agilent1100-MS-52011LC, nano LC, EXTREMA㸧
❑⏣
ᰗ℩
຾㔝
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≟ሯ

࠙ᰗᡞᆅ༊ࠚ
ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦JNM-ECA500ࠊJNM-ECX400PࠊJNM-ECZ600R/M1㸧
࠙་Ꮫᆅ༊ࠚ
ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨
㸦AVANCE III 600ࠊAVANCE III 800㸧

࠙ᰗᡞᆅ༊ࠚ
㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦JES-FA100㸧
࠙་Ꮫᆅ༊ࠚ
㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦EMX Micro-6/1㸧⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮

ᕤᏛ㒊
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ᕤᏛ㒊
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ㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ⿦⨨㸦ULTIMA2 ᇼሙ㸧⺯ග X ⥺ศᯒ⿦⨨
㸦S8-TIGER㸧᭷ᶵᚤ㔞ඖ⣲ศᯒ⿦⨨
㸦CHN JM-10ࠊJHA102ࠊJMSU10㸧

2574
2251
2256
2253
2572
3080
2588
2802
2418
2815
2975
5530

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ࠌ

࿘ᖹ
Ṋᚿ
⪽
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ⰾᡂ
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2539
2523
2520
2525
2533
2888

ᕤᏛ㒊
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ࠌ
ࠌ
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ᒣෆ
ᒣᐙ

⚈୍
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➗Ꮚ
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2573
2251
2253
2589
2629
2681
2706
2616
2588
2607
2596
2686
2924
2888
2914
2897
3903

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ᛂ⏝⏕≀⛉Ꮫ㒊ࠌࠌࠌ≉ู༠ຊ◊✲ဨ࠙ᰗᡞᆅ༊ࠚ
‫۔‬ᒾᮏࣇ࣮ࣟᘧ⢏Ꮚീศᯒ⿦⨨㸦FPIA-3000㸧Ḉ⏣⢏Ꮚᚄ࣭ࢮ࣮ࢱ㟁఩࣭ศᏊ㔞 ᐃ⿦⨨㸦Zetasizer Nano ZS㸧 Ṋ㔝࣓࣮ࣞ࢜ࢱ࣮㸦AR-*ჟ.*㸧୕㍯ືⓗ⢓ᙎᛶ ᐃ⿦⨨㸦'0$4.*㸧
すὠ

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2565
2888

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2572
2924
2889
2930
2707

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ྜྷᯇ ୕༤
຾⏣ 㛗㈗
ⴗཎ ᏹ᫂
ᾏ⪁ཎ ᫀᘯ
኱㇂ ලᖾ
ᐑᮏ Ꮫ
᪩ᕝ ᖾ⏨
ᑠᓥ ᝆ᥹
࣒ࣜ ࣮ࣜ࣡⏣୰ ㈗ྂᕝ ┿୍*

࠙ᰗᡞᆅ༊ࠚ‫۔‬㧗ᶫ㉸㧗㏿ᗘ⌧㇟ゎᯒࢩࢫࢸ࣒
㉸㧗㏿ᗘ᧜ᙳ⿦⨨㸦NAC FS501ࠊHyperVision HPV-2A㸧
ᐑᆏỗ⏝㧗㏿ᗘ᧜ᙳ⿦⨨㸦NAC MEMECAM㸧⳥ᆅ㧗㏿ᗘ㉥እ⥺࣓࢝ࣛ㸦FLIR SC7500TEC㸧ᮅཎỗ⏝㉥እ⥺࣓࢝ࣛ㸦LAIRD 3ASH㸧ᑠᯘࣃࣝࢫࢪ࢙ࢿ࣮ࣞࢱ㸦DG-535㸧
すὠPIV ࢩࢫࢸ࣒㸦ES1.0-NI1422ࠊTwinsUltra120ࠊVPP-2D㸧
࠙ᰗᡞᆅ༊ࠚ
‫۔‬ἅỈ
ᑠᆺᶵჾ
ྜྷᯇ
㸦UV-Vis࣭FT-IR࣭㢧ᚤ FT-IR࣭ReactIR࣭IlluminatIR࣭CD࣭ ⴗཎ᪕ගᗘィ㸧኱▮⺯ගศගගᗘィ㸦O950㸧
Ṋ㔝⺯ගᑑ࿨ ᐃ⿦⨨㸦Quantaurus-Tau㸧ஂ⡿⤯ᑐ PL 㔞Ꮚ཰⋡ ᐃ⿦⨨㸦Quantaurus-QY㸧ྜྷ⏣ศග⺯ගගᗘィ㸦FP-8600㸧
Ⱚཎࣇ࢙࣒ࢺ⛊ࣇ࢓࢖ࣂ࣮࣮ࣞࢨ࣮㸦BS-60-YS㸧ᐑᮏࢸࣛ࣊ࣝࢶศග㉮ᰝᆺ㢧ᚤ㙾㸦THz-TDS㸧▼㯮㢧ᚤ࣮ࣞࢨ࣮࣐ࣛࣥศගࢩࢫࢸ࣒❑⏣㸦NRS-1000㸧኱ᶫ⇕ศᯒࢩࢫࢸ࣒
ᒾᮏ
㸦DSC࣭TMA࣭TG-DTA࣭TG-DSC㸧
すὠ
㸦EXSTAR-6000, NEXTA㸧ᰗ℩࠙ᰗᡞᆅ༊ࠚ
X ⥺࣐࢖ࢡࣟ CT ࢫ࢟ࣕࢼ࣮㸦Skyscan1172㸧
࠙་Ꮫᆅ༊ࠚ
㉸㧗㍤ᗘ X ⥺ᅇᢡ⿦⨨㸦FR-E Super Bright㸧‫۔‬すὠ ㈗ஂᾏ⪁ཎ ᫀᘯ
ᒾᮏ ᝅᚿ
ᓥ⏣ ᩔᗈ
௒Ἠ 㕲ᖹ
୸ᒣ ದྐ*



2

ᶵჾ⤂௓

1. ᶵჾ୍ぴ࠙ᰗᡞᆅ༊ࠚ ⾲ 2-1-1. ⣡ධᖺᗘ࡜つ᱁
ရ
1.

ྡ

⣡ධᖺᗘ

つ

᱁

኱ᆺ㟁Ꮚ㢧ᚤ㙾࣭ࢹࢪࢱࣝ㢧ᚤ㙾኱ᆺ㟁Ꮚ㢧ᚤ㙾㸦TEM㸧኱ᆺ㟁Ꮚ㢧ᚤ㙾㸦TEM㸧STEM, EDX ௜

H21 ᖺᗘ
ࠌ᪥❧〇సᡤ H-7000
᪥ᮏ㟁Ꮚ JEM-2100㸪ᇼሙ࢞ࣛࢫࢼ࢖ࣇస〇ჾࠌ㉸࣑ࢡࣟࢺ࣮࣒
┿✵⵨╔⿦⨨
ࢹ࢕ࣥࣉࣝࢢࣛ࢖ࣥࢲ࣮
࢖࢜ࣥࢫࣃࢵࢱࠊ࣮࢝࣎ࣥࢥ࣮ࢱ࣮
ࢿ࢜࢜ࢫ࣑࣒࢘ࢥ࣮ࢱ࣮
࢖࣑࢜ࣥࣜࣥࢢ⿦⨨⢭ᐦ࢖࣏࢜ࣥࣜࢵࢩࣥࢢ⿦⨨㉸㡢Ἴࢹ࢕ࢫࢡ࢝ࢵࢱ࣮
ࢲ࢖ࣖࣔࣥࢻ࣡࢖࣮ࣖࢯ࣮
ࢫࣃࢵࢱࢥ࣮ࢱ࣮
࣮࢝࣎ࣥࢥ࣮ࢱ࣮
ග◳໬ᛶᶞ⬡ໟᇙ⿦⨨

S60 ᖺᗘ
H9 ᖺᗘ
ࠌ
S59 ᖺᗘ
H5 ᖺᗘ
H8 ᖺᗘ
H17 ᖺᗘ
H19 ᖺᗘ
H21 ᖺᗘ
H22 ᖺᗘࠌࠌࠌ
R3 ᖺᗘ୕៞⛉Ꮫ ࣓ࢵࢧ࣮Cࣛ࢖࢝ ࢞ࣛࢫࢼ࢖ࣇ࣓࣮࣮࢝ (0.05
ࣛ࢖࢝
ULTRACUT-UCT
᪥❧〇సᡤ HUS-5GB
࢞ࢱࣥ
MODEL 656 N᪥❧〇సᡤ E-102㸪E-201
࣓࢖࣡ࣇ࢛࣮ࢩࢫ Neoc-ST᪥❧〇సᡤ E-3500 ᙧ࢞ࢱࣥ
MODEL 691
࢞ࢱࣥ
MODEL 601࣓࢖࣡ࣇ࢛࣮ࢩࢫ DWS3242
࣓࢖࣡ࣇ࢛࣮ࢩࢫ SC200
࣓࢖࣡ࣇ࢛࣮ࢩࢫ CADE-EHS
࣓࢖࣡ࣇ࢛࣮ࢩࢫ CT-UVBox㟁⏺ᨺฟᆺ㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾 (FE-SEM) EDX ௜㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾 (N-SEM)㧗ศゎ⬟㟁⏺ᨺฟᆺ㉮ᰝ㟁Ꮚ㢧ᚤ㙾 (FE-SEM)
࢚ࢿࣝࢠ࣮ศᩓᆺ X ⥺ศᯒ⿦⨨

H14 ᖺᗘ
H15 ᖺᗘ
H19 ᖺᗘ
R2 ᖺᗘ

᪥❧〇సᡤ S-4300㸪ᇼሙ〇సᡤ EX-220
᪥❧〇సᡤ S-3000N
᪥❧〇సᡤ S-4800
OXFORD Instruments Ultim MAX100ࢹࢪࢱ࣐ࣝ࢖ࢡࣟࢫࢥ࣮ࣉ

H22 ᖺᗘ

ࣛ࢖࣐࢝࢖ࢡࣟࢩࢫࢸ࣒ࢬ

EX-220

DVM50002.

㉮ᰝᆺࣉ࣮ࣟࣈ㢧ᚤ㙾ࢩࢫࢸ࣒㸦SPM㸧

H25 ᖺᗘ

᪥❧ࣁ࢖ࢸࢡࢧ࢖࢚ࣥࢫ
኱ᆺࣘࢽࢵࢺ
AFM5400L⎔ቃไᚚࣘࢽࢵࢺ AFM5300E

3.

㉮ᰝᆺ X ⥺ග㟁Ꮚศගศᯒ⿦⨨ (XPS/ESCA)

H19 ᖺᗘ

࢔ࣝࣂࢵࢡ࣭ࣇ࢓࢖

H13 ᖺᗘ
H15 ᖺᗘ
ࠌ
H23 ᖺᗘ
H26 ᖺᗘ
H15 ᖺᗘ
H26 ᖺᗘ
R3 ᖺᗘ

᪥ᮏ㟁Ꮚ GC-Mate II᪥ᮏ㟁Ꮚ JMS-700
᪥ᮏ㟁Ꮚ $0681 .
᪥ᮏ㟁Ꮚ JMS-T100LP
ᓥὠ〇సᡤ AXIMA-Resonance࢔ࢪࣞࣥࢺ 1100 MS-52011LC
ᓥὠ〇సᡤ LC-20ADnano᪥ᮏศග EXTREMAࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦FT-NMR㸧
ෆヂ㸸500 MHz
ᅛయ ᐃ⿵ຓ⿦⨨400 MHz
600 MHzH14 ᖺᗘ
H18 ᖺᗘ
ࠌ
R3 ᖺᗘ

᪥ᮏ㟁Ꮚ
᪥ᮏ㟁Ꮚ
᪥ᮏ㟁Ꮚ
᪥ᮏ㟁Ꮚ

JNM ECA500
NM-93030CPM
JNM ECX400PJNM ECZ600R/M1

㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦ESR㸧

H14 ᖺᗘ

᪥ᮏ㟁Ꮚ

JES

4.

5.

6.

㧗ศゎ⬟㉁㔞ศᯒ⿦⨨㸦MS㸧ࠌࠌࠌࠌᾮయࢡ࣐ࣟࢺࢢࣛࣇ㸦HPLC㸧
ࠌ㸦nanoLC㸧ࠌ㸦HPLC㸧



Quantera SXM-GS

FA100

7.

ࢪࣙࣂࣥ࢖࣎ࣥ ULTIMA2㸦ᇼሙ〇సᡤ㸧ㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ⿦⨨㸦ICP-AES㸧࣐࢖ࢡࣟἼศᯒ๓ฎ⌮⿦⨨

H20 ᖺᗘ
H30 ᖺᗘ

CEM ࢪࣕࣃࣥ

8.

Ἴ㛗ศᩓᆺ⺯ග X ⥺ศᯒ⿦⨨㸦XRF㸧
ࣅ࣮ࢻసᡂ⿦⨨⢊○ᶵ

H23 ᖺᗘ
ࠌࠌBrukerAXS S8 TIGER 1kW.DWDQD[ .3ULPH(OHFWULF)OX[HUఀ⸨〇సᡤ MC-4A

9.

᭷ᶵᚤ㔞ඖ⣲ศᯒࢩࢫࢸ࣒㸦OEA㸧᭷ᶵᚤ㔞ඖ⣲ศᯒ⿦⨨࣮࢜ࢺࢧࣥࣉ࣮ࣛ
◲㯤ศᯒࣘࢽࢵࢺ

H23 ᖺᗘ
ࠌࠌJ㺃Science㺃Lab
J㺃Science㺃Lab
J㺃Science㺃Lab

10. ㉸㧗㏿ᗘ⌧㇟ゎᯒࢩࢫࢸ࣒
ෆヂ㸸㉸㧗㏿ᗘ᧜ᙳ⿦⨨ࠌỗ⏝㧗㏿ᗘ᧜ᙳ⿦⨨㧗㏿ᗘ㉥እ⥺࣓࢝ࣛỗ⏝㉥እ⥺࣓࢝ࣛ
ࣃࣝࢫࢪ࢙ࢿ࣮ࣞࢱ
PIV

H10 ᖺᗘ
H23 ᖺᗘ
ࠌࠌ
H10 ᖺᗘ
ࠌ
H16 ᖺᗘ

NAC
FS501
ᓥὠ〇సᡤ HyperVision HPV-2A
NAC
MEMECAM GX-8
FLIR SC7500TEC
ࢽࢥࣥ
LAIRD 3ASH
NAC
DG-535࢜ࢵࢡࢫࣇ࢛࣮ࢻ࣮ࣞࢨ࣮ES1.0-NI1422

11. ⣸እྍどศගගᗘィ㸦UV-Vis㸧ࣇ࣮࢚ࣜኚ᥮ᆺ㉥እศගගᗘィ㸦FT-IR㸧ࣇ࣮࢚ࣜኚ᥮ᆺ㉥እศගගᗘィ㸦FT-IR㸧㢧ᚤ࣭཯ᑕᆺ㉥እศගගᗘィ㸦㢧ᚤ IR㸧
In Situ ࣇ࣮࢚ࣜኚ᥮㉥እศගගᗘィ㸦FT-IR㸧᪕ගィ

H22 ᖺᗘ
ࠌ
R1 ᖺᗘ
H14 ᖺᗘ
H15 ᖺᗘ
H22 ᖺᗘ

ࣃ㸫࢚࣐࣮࢟ࣥࣝ O950
ࣃ࣮࢚࣐࣮࢟ࣥࣝ Spectrum100
᪥ᮏศග FT/IR-4700
᪥ᮏศග 460Plus࣓ࢺ࣮࣭ࣛࢺࣞࢻ ReactIR 4000᪥ᮏศග P-2300

12. ෇஧Ⰽᛶศᩓィ㸦CD㸧

H13 ᖺᗘ

᪥ᮏศග

13. ࣇ࢛ࢺ࣑ࣝࢿࢵࢭࣥࢫศᯒࢩࢫࢸ࣒
⺯ගᑑ࿨ ᐃ⿦⨨㸦Tau㸧⤯ᑐ PL 㔞Ꮚ཰⋡ ᐃ⿦⨨㸦QY㸧
ศග⺯ගගᗘィ㸦FL㸧

H23 ᖺᗘ
ࠌࠌ὾ᯇ࣍ࢺࢽࢡࢫ Quantaurus-Tau὾ᯇ࣍ࢺࢽࢡࢫ Quantaurus-QY
᪥ᮏศග FP-8600

14. ࢸࣛ࣊ࣝࢶ࢖࣓࣮ࢪࣥࢢࢩࢫࢸ࣒
ࣇ࢙࣒ࢺ⛊ࣇ࢓࢖ࣂ࣮࣮ࣞࢨ࣮
ࢸࣛ࣊ࣝࢶศග㉮ᰝᆺ㢧ᚤ㙾

H17 ᖺᗘ
H19 ᖺᗘ

࢔࢖ࢩࣥ⢭ᶵ ࣇ࢙࣒ࢺࣛ࢖ࢺ BS-60-YS
࢜ࢨ࣡
THz-TDS15. 㢧ᚤ࣮ࣞࢨ࣮࣐ࣛࣥศගࢩࢫࢸ࣒

H14 ᖺᗘ

᪥ᮏศග

16. ⇕ศᯒࢩࢫࢸ࣒
♧ᕪ⇕㔞ィ㸦DSC㸧
⇕㔜㔞࣭♧ᕪ⇕ྠ᫬ ᐃ⿦⨨㸦TG/DTA㸧⇕ᶵᲔศᯒ⿦⨨㸦TMA㸧
⇕㔜㔞࣭♧ᕪ⇕ྠ᫬ ᐃ⿦⨨㸦TG/DSC㸧

H15 ᖺᗘࠌࠌ
R2 ᖺᗘ࢚ࢫ࢔࢖࢔࢖ EXSTAR-6000 Series
DSC6200, DSC6100,
TG/DTA6300
TMA/SS6100, TMA/SS6300
᪥❧ࣁ࢖ࢸࢡࠊNEXTA Series STA300

17. ⢏Ꮚゎᯒࢩࢫࢸ࣒
ࣇ࣮ࣟᘧ⢏Ꮚീศᯒ⿦⨨⢏Ꮚᚄ࣭ࢮ࣮ࢱ㟁఩࣭ศᏊ㔞

H22 ᖺᗘ
ࠌ࣐ࣝࣂ࣮ࣥ FPIA-3000
࣐ࣝࣂ࣮ࣥ Zetasizer Nano ZS

18. ⢓ᙎᛶゎᯒࢩࢫࢸ࣒
࣓࣮ࣞ࢜ࢱ࣮
ືⓗ⢓ᙎᛶ ᐃ⿦⨨H22 ᖺᗘ
ࠌ

TA࣭࢖ࣥࢫࢶ࣓ࣝࣥࢺ
TA࣭࢖ࣥࢫࢶ࣓ࣝࣥࢺ

19. ≀㉁ᚤ⣽ᵓ㐀ゎᯒࢩࢫࢸ࣒
X ⥺࣐࢖ࢡࣟ CT ࢫ࢟ࣕࢼX ⥺ᅇᢡ⿦⨨*H22 ᖺᗘ
H30 ᖺᗘ

Bruker 6.<6&$1-GU
ࣜ࢞ࢡ SmartLab㸦9 kW㸧

ᐃ⿦⨨



MARS6

JM10
JMA102JMSU10J-820P

NRS-1000

AR-GII .G'0$4.*20. ࡑࡢ௚
࣑ࢡࣟኳ⛗

H19 ᖺᗘ

ࢨࣝࢺࣜ࢘ࢫ MC5࠙་Ꮫᆅ༊ࠚ⾲ 2-1-2. ⣡ධᖺᗘ࡜つ᱁
ရ

ྡ

⣡ධᖺᗘ

つ

1. ᰾☢Ẽඹ㬆ศග⿦⨨㸦NMR㸧ෆヂ㸸800MHz
600MHzH21 ᖺᗘ
ࠌBruker BioSpin
Bruker BioSpin

2.

㉸㧗㍤ᗘ X ⥺ᅇᢡ⿦⨨

H17 ᖺᗘ

Rigaku3.

㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦ESR㸧

H21 ᖺᗘ

Bruker BioSpin

᱁
AVANCE III 800
AVANCE III 600

FR-E SuperBright
EMXmicro2. ᶵჾ㓄⨨ሙᡤ࠙ᰗᡞᆅ༊ࠚ⾲ 2-2-1. ⥲ྜ◊✲Ჷჟ 㝵ᶵჾྡ࣓࣮࣮࣭࢝ᆺ␒

㉁㔞ศᯒ⿦⨨ (MS)ᾮయࢡ࣐ࣟࢺࢢࣛࣇAXIMA Resonance

A

᪥ᮏ㟁Ꮚ

JMS-T100LP (AccuTOF LC-plus)

B

᪥ᮏ㟁Ꮚ

JMS-700C᪥ᮏ㟁Ꮚ*&PDWHჟ᪥ᮏ㟁Ꮚ

JMS-$0681 .-9)

ᓥὠnanoLCEXTREMAE᪥ᮏ㟁Ꮚ

JMN ECX-400p

F

᪥ᮏ㟁Ꮚ

JMN ECA-500࣭NM-93030CPM᪥ᮏ㟁Ꮚ

JMN ECZ600R/M1

TA࣭࢖ࣥࢫࢶ࣓ࣝࣥࢺ

'0$4.*㢧ᚤࣇ࣮࢚ࣜኚ᥮㉥እศගගᗘィ㸦㢧ᚤ IR㸧 ᪥ᮏศග2

I

460Plus, IRT-30

Jࣃ࣮࢚࣐࣮࢟ࣥࣝ Spectrum100
࢚ࢫ࢔࢖࢔࢖ EXSTAR-6000 Series:
DSC, TG/DTA, TMA
᪥ᮏศග

.
L

J-820P

In Situ ࣇ࣮࢚ࣜኚ᥮㉥እศගගᗘィ㸦FT-IR㸧 ࣓ࢺ࣮ࣛࢺࣞࢻ

G
H

ືⓗ⢓ᙎᛶ

෇஧Ⰽᛶศᩓィ㸦CD㸧

E

᪥ᮏศග

AR-*.*⇕ศᯒࢩࢫࢸ࣒

D

B

MS-52011LC

TA࣭࢖ࣥࢫࢶ࣓ࣝࣥࢺ

ࣇ࣮࢚ࣜኚ᥮㉥እศගගᗘィ㸦FT-IR㸧㸯

A࣓࣮ࣞ࢜ࢱ࣮
ᐃ⿦⨨

ሙᡤ

ᓥὠ

࢔ࢪࣞࣥࢺ

ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦FT-NMR㸧ᐊྡReactIR

4000

M

FT/IR-4700

ࣇ࣮࢚ࣜኚ᥮㉥እศගගᗘィ㸦FT-IR㸧᪥ᮏศග⣸እྍどศගගᗘィ㸦UV-Vis㸧ࣃ㸫࢚࣐࣮࢟ࣥࣝ

ศග⺯ගගᗘィ㸦FL㸧᪥ᮏศග⤯ᑐ PL 㔞Ꮚ཰⋡὾ᯇ࣍ࢺࢽࢡࢫ

Quantaurus-QY

P὾ᯇ࣍ࢺࢽࢡࢫ

Quantaurus-Tau

Q

⺯ගᑑ࿨

ᐃ⿦⨨㸦QY㸧ᐃ⿦⨨㸦Tau㸧

LAMBDA 950

FP-8600ࣇ࣮ࣟᘧ⢏Ꮚീศᯒ⿦⨨࣐ࣝࣂ࣮ࣥ

FPIA-3000⢭ᐦኳ⛗ࢨࣝࢺࣜ࢘ࢫ

MC5
Zetasizer Nano ZS

᪕ගィ

᪥ᮏศග

P-2300㢧ᚤ࣮ࣞࢨ࣮࣐ࣛࣥศගࢩࢫࢸ࣒

᪥ᮏศග
NRS-1000
J-Science Lab
CHN JM10/JAM102/JMSU10/JMR10ᐃ⿦⨨᭷ᶵᚤ㔞ඖ⣲ศᯒ⿦⨨㸦OEA㸧
㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾㸦TEM㸧

N
O

R

࣐ࣝࣂ࣮ࣥ

⢏Ꮚᚄ࣭ࢮ࣮ࢱ㟁఩࣭ศᏊ㔞

3

S
T
U

᪥ᮏ㟁Ꮚ

JEM-2100

4

V

᪥❧〇సᡤ

H-70005Wࢹࢪࢱ࣐ࣝ࢖ࢡࣟࢫࢥ࣮ࣉ

ࣛ࢖࣐࢝࢖ࢡࣟࢩࢫࢸ࣒ࢬ

࢞ࣛࢫࢼ࢖ࣇస〇ჾ୕៞⛉Ꮫ

DVM-5000

࣓ࢵࢧ࣮Cࣛ࢖࢝ ࢞ࣛࢫࢼ࢖ࣇ࣓࣮࣮࢝ EM

X
6㉸࣑ࢡࣟࢺ࣮࣒ࣛ࢖࢝ULTRACUT-UCT㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾㸦N-SEM㸧᪥❧〇సᡤ

S-3000NY㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾㸦FE-SEM㸧᪥❧〇సᡤ

S-4300Z࢚ࢿࣝࢠ࣮ศᩓᆺ X ⥺ศᯒ⿦⨨ᇼሙ〇సᡤ

EX-220㧗ศゎ⬟㟁⏺ᨺฟᆺ㉮ᰝ㟁Ꮚ㢧ᚤ㙾᪥❧〇సᡤ

S-4800࢚ࢿࣝࢠ࣮ศᩓᆺ X ⥺ศᯒ⿦⨨ᇼሙ〇సᡤ

EX-250 X-actࢿ࢜࢜ࢫ࣑࣒࢘ࢥ࣮ࢱ࣮

࣓࢖࣡ࣇ࢛࣮ࢩࢫ

Neoc-STග◳໬ᛶᶞ⬡ໟᇙ⿦⨨࣓࢖࣡ࣇ࢛࣮ࢩࢫ

CT-UVBoxࢲ࢖ࣖࣔࣥࢻ࣡࢖࣮ࣖࢯ࣮

࣓࢖࣡ࣇ࢛࣮ࢩࢫ

DWS3242࢖࢜ࣥࢫࣃࢵࢱ

᪥❧〇సᡤE-102, E-201

ࢫࣃࢵࢱࢥ࣮ࢱ࣮

POLARON

SC7640࢖࣑࢜ࣥࣜࣥࢢ⿦⨨᪥❧〇సᡤ

E-3500ࢹ࢕ࣥࣉࣝࢢࣛ࢖ࣥࢲ࣮

࢞ࢱࣥ

MODEL 656N

⢭ᐦ࢖࣏࢜ࣥࣜࢵࢩࣥࢢ⿦⨨࢞ࢱࣥ

MODEL 691㉸㡢Ἴࢹ࢕ࢫࢡ࢝ࢵࢱ࣮

࢞ࢱࣥ

MODEL 601┿✵⵨╔⿦⨨

᪥❧〇సᡤࢫࣃࢵࢱࢥ࣮ࢱ࣮

࣓࢖࣡ࣇ࢛࣮ࢩࢫ

a

b

c
6
d

HUS-5GBSC200

e࣓࢖࣡ࣇ࢛࣮ࢩࢫ CADE-EHS
᪥❧ࣁ࢖ࢸࢡࢧ࢖࢚ࣥࢫ
㉮ᰝᆺࣉ࣮ࣟࣈ㢧ᚤ㙾ࢩࢫࢸ࣒㸦SPM/AFM㸧
AFM5400L, AFM5300E
࣮࢝࣎ࣥࢥ࣮ࢱ࣮

fㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ⿦⨨㸦ICP-AES㸧 ࢪࣙࣂࣥ࢖࣎ࣥ ULTIMA2㸦ᇼሙ〇సᡤ㸧࣐࢖ࢡࣟἼศᯒ๓ฎ⌮⿦⨨

CEM Japan

X ⥺ᅇᢡ⿦⨨*ࣜ࢞ࢡ㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦ESR㸧᪥ᮏ㟁ᏊἼ㛗ศᩓᆺ⺯ග X ⥺ศᯒ⿦⨨㸦XRF㸧

BrukerAXS S8 TIGER-MA 1kW

ࣅ࣮ࢻసᡂ⿦⨨.DWDQD[.3ULPH(OHFWULF)OX[HU⢊○ᶵ㉮ᰝᆺ X ⥺ග㟁Ꮚศගศᯒ⿦⨨㸦XPS/ESCA㸧ఀ⸨〇సᡤ MC-4Ah

SmartLab㸦9 kW㸧

i

JES-FA100

࢔ࣝࣂࢵࢡ࣭ࣇ࢓࢖

7

Bruker

6.<6&$1-GUࢸࣛ࣊ࣝࢶศග㉮ᰝᆺ㢧ᚤ㙾࢜ࢨ࣡

THz-TDSࣇ࢙࣒ࢺ⛊ࣇ࢓࢖ࣂ࣮࣮ࣞࢨ࣮

࢔࢖ࢩࣥ⢭ᶵ

㉸㧗㏿ᗘ᧜ᙳ⿦⨨NAC⇕⏬ീゎᯒ⿦⨨FLIR SC7500STECjk

Quantera SXM-GS

X ⥺࣐࢖ࢡࣟ CT ࢫ࢟ࣕࢼ࣮

㉸㧗㏿ᗘ᧜ᙳ⿦⨨

g

MARS6

l

ࣇ࢙࣒ࢺࣛ࢖ࢺ BS-60-YS

8

m

ࢭ࣑
ࢼ࣮
ᐊ

n

FS501
HyperVision HPV-2A

ᓥὠ〇సᡤ
NAC

HS-4540-2㉸㧗㏿ᗘ᧜ᙳ⿦⨨NAC

MEMRCAM GX-8⇕⏬ീゎᯒ⿦⨨ࢽࢥࣥࣃࣝࢫࢪ࢙ࢿ࣮ࣞࢱ

NAC

PIV

࢜ࢵࢡࢫࣇ࢛࣮ࢻ࣮ࣞࢨ࣮ ES1.0-NI1422

ࢲࣈࣝࣃࣝࢫ࣮ࣞࢨ࣮

࢝ࣥࢸࣝ

ࣉࣟࢭࢵࢧ

᪥ᮏ࣮ࣞࢨ࣮

ࢧ࣮࣐ࣝࣅࢪࣙࣥ

LAIRD 3ASH

DG-535
TwinsUltra120
VPP-2Dࡑࡢ௚㸸࣮ࣞࢨ࣮↷᫂⿦⨨ࠊ㘄๣ᡂᆺᶵࠊἜᅽࣉࣞࢫࠊ㉸㡢ἼὙίᶵࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊࡀ⟶⌮ࡍࡿඹ⏝ᶵჾ࡜ࡋ࡚ࠊᶵჾศᯒᐊ  ࡟タ⨨ࠋᅗ 2-1. ⥲ྜ◊✲Ჷϩ 1 㝵 ᶵჾ㓄⨨ᅗ࠙་Ꮫᆅ༊ࠚ⾲ 2-2-2. ⏕࿨⛉ᏛᲷ 1 㝵ᶵჾྡ࣓࣮࣮࣭࢝ᆺ␒ሙ ᡤ

Bruker BioSpin AVANCE III 600

A

Bruker BioSpin AVANCE III 800

B㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦ESR㸧

Bruker BioSpin EMXmicroC㉸㧗㍤ᗘ X ⥺ᅇᢡ⿦⨨

Rigaku FR-E SuperBrightD᰾☢Ẽඹ㬆ศග⿦⨨㸦NMR㸧ᅗ 2-2. ⏕࿨⛉ᏛᲷ 1 㝵 ᶵჾ㓄⨨ᅗ

3. ඹ⏝ᶵჾࡢᴫせ࠙ᰗᡞᆅ༊ࠚ
1. ኱ᆺ㟁Ꮚ㢧ᚤ㙾࣭ࢹࢪࢱࣝ㢧ᚤ㙾࠙ᶵჾศᯒᐊ 4, 5, 6ࠚ㟁Ꮚ㢧ᚤ㙾࡟࠾ࡅࡿ㟁Ꮚ⥺ࡢἼ㛗ࡣྍどග⥺ࡢࡶࡢࡼࡾࡶ࠿࡞ࡾ▷ࡃࠊ㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾ࡢሙྜࠊ⌮ㄽⓗ࡟ࡣ 1 Å ⛬ᗘࡢศゎ⬟ࡀ࠶ࡿࠋᙜศ㔝࡟ࡣࠊ2 ྎࡢ㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾㸦H-7000㺂 JEM-2100㸧ࠊ࠾ࡼࡧࠊ3 ྎࡢ㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾㸦S-4300㺂 S-3000N㺂 S-4800㸧ࡀタ⨨ࡉࢀ࡚࠸ࡿࠋ
H-7000 ࡣࢱࣥࢢࢫࢸࣥ㸦W㸧㟁Ꮚ㖠ࢆᦚ㍕ࡋ࡚࠾ࡾࠊ125 kV ࡲ࡛ 6 ẁ㝵ࡢຍ㏿㟁ᅽ࡟ࡼࡾపಸ⋡࠿ࡽ⏬ീࢆほᐹࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ⏕≀ᮦᩱ࠾ࡼࡧ㠀⏕≀ᮦᩱࡢ㉸ⷧษ∦ࢆ 50 ಸ࠿ࡽ 60 ୓ಸ࡟ᣑ኱ࡋࠊෆ㒊ࡢᚤ⣽ᵓ㐀ࡢほᐹࡀྍ⬟࡛࠶ࡿࠋ᱁Ꮚീࡢศゎ⬟ࡣ 2.04 Å ࡛࠶ࡿࠋᚓࡽࢀࡓ⏬
ീࢆ CCD ࣓࢝ࣛ࡟ྲྀࡾ㎸ࡳゎᯒࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

JEM-2100 ࡣ㧗ฟຊ࣭㧗⢭ᗘࡢ LaB6 㟁Ꮚ㖠ࢆᦚ㍕ࡋ࡚࠾ࡾࠊ5 ẁ㝵࡛ຍ㏿㟁ᅽࢆ 200 kV ࡲ࡛ୖࡆࡿࡇ࡜ࡀ࡛ࡁࡿࠋ⏕≀࣭㠀⏕≀ᮦᩱࡢ㉸ⷧษ∦ࢆ 2,000 ಸ࠿ࡽ 150 ୓ಸ࡟ᣑ኱ࡋࠊෆ㒊ࡢᚤ⣽ᵓ㐀ࢆほᐹ࡛ࡁࡿࠋ᱁
Ꮚീࡢศゎ⬟ࡣ 1.4 Å ࡛࠶ࡿࠋࢹ࣮ࢱࡣ CCD ࣓࢝ࣛ࡟ྲྀࡾ㎸ࡳゎᯒࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋࡲࡓࠊSTEM ᶵ⬟ࡀ࠶ࡾࠊᑐ㇟ࢆ 3 ḟඖ࡛ほᐹࡋࡓ
3D ࢺࣔࢢࣛࣇࢆᚓࡿࡇ࡜ࡶ࡛ࡁࡿࠋຍ࠼࡚ࠊ᥋⥆ࡋࡓ X ⥺ศᯒ⿦⨨
㸦EDX㸧࡟ࡼࡿ࣍࢘⣲ࡼࡾ㔜࠸ඖ⣲ࡢศᕸゎᯒࡶྍ⬟࡛࠶ࡿࠋS-4300 ࡣ㟁⏺ᨺฟᆺ㟁Ꮚ㖠㸦FEG㸧ࢆഛ࠼ࡓ⿦⨨࡛ࠊຍ㏿㟁ᅽࡣ 0.5 ~30 kV ࡢ⠊ᅖ࡛ྍኚࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡾࠊಸ⋡ࡣ 20 - 500,000 ಸࠊศゎ⬟ࡣ 1.5 nm㸦15 kV㸧࠾ࡼࡧ 5.0 nm㸦1 kV㸧࡛࠶ࡿࠋ㧗㍤ᗘ࡞㟁Ꮚ㖠࡟ࡼࡾࠊపຍ㏿㟁ᅽࠊ౛࠼ࡤࠊ1 kV ࡛ࡶ㧗ศゎീࢆᚓࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋࡲࡓࠊపຍ㏿㟁ᅽ࡟࡚ࠊ↓⵨╔ほᐹ࡛ࡁࡿヨᩱࡶ࠶ࡿࠋ⿦ഛࡉࢀࡓ
X ⥺ศᯒ⿦⨨ EX-220 ࡣⅣ⣲࡞࡝ࡢඖ⣲ศᯒࡀ࡛ࡁࡿࠋ

S-3000N ࡣ㏻ᖖࡢࢱࣥࢢࢫࢸࣥ࣊࢔ࣆࣥᆺ㸦⇕㟁Ꮚᨺฟᆺ㸧㟁Ꮚ㖠ࢆഛ࠼ࡓ⿦⨨࡛࠶ࡾࠊຍ㏿㟁ᅽࡀ 0.3 ~ 30 kV ࡢ⠊ᅖ࡛౑⏝ࡍࡿࠋಸ⋡ࡣ 5 ~300,000 ಸ࡛ࠊ஧ḟ㟁Ꮚീศゎ⬟ࡣ 3.0 nm㸦㧗┿✵࣮ࣔࢻࠊຍ㏿㟁ᅽ 25kV㸧ࠊ཯ᑕ㟁Ꮚീศゎ⬟ࡣ 4.0 nm㸦ప┿✵࣮ࣔࢻࠊຍ㏿㟁ᅽ 25 kV㸧࡛࠶ࡿࠋࡇࡢ SEM ࡢ≉ᚩࡣࠊప┿✵ 270 Pa㸦⣙ 2 torr㸧࡛ヨᩱࡢほᐹࡀྍ⬟࡞ࡇ࡜࡛࠶ࡿɽ
S-4800 ࡣ㟁⏺ᨺฟᆺ㟁Ꮚ㖠㸦FEG㸧ࢆഛ࠼ࡓ⿦⨨࡛ࠊS-4300 ࡼࡾᛶ⬟࡜౑࠸຾ᡭࡀྥୖࡋ࡚࠸ࡿࠋヨᩱࡢ X-Y ⛣ື࠾ࡼࡧᅇ㌿ࡢ 3 ㍈ࡀ㟁ື࡛ㄪᩚ࡛ࡁࡿࠋຍ㏿㟁ᅽࡀ 15 kV ࡛ 1.0 nmࠊ1 kV ࡛ࡶ 2 nm ࡢ㧗ศゎ⬟ࢆ᭷ࡍࡿࠋヨᩱࢫࢸ࣮ࢪ࡟࣐࢖ࢼࢫࡢ㟁ᅽࢆ࠿ࡅࠊධᑕ㟁Ꮚࢆῶ㏿ࡍࡿࣜࢱ࣮ࢹ࢕ࣥࢢᶵ⬟ࢆ⏝࠸ࡿ࡜ 1 kV ࡛ 1.4 nm ࡢศゎ⬟ࡀᚓࡽࢀࡿࠋX ⥺ศᯒ⿦⨨(EDS)Ultim MAX100 ࡀ᥋⥆ࡉࢀ࡚࠾ࡾࠊSEM ീ࡟ྜࢃࡏ࡚ඖ⣲ศᯒࡀྍ⬟࡛࠶ࡿࠋ

ࢿ࢜࢜ࢫ࣑࣒࢘ࢥ࣮ࢱ Neoc Pro ࡣࣉࣛࢬ࣐ CVD ᡂ⭷ࢆ᥇⏝ࡋࡓ࢜ࢫ࣑
࣒࢘㔠ᒓ⿕⭷ࢆ〇⭷ࡍࡿࡓࡵࡢᶵჾࠋ┿✵ࢳࣕࣥࣂ࣮ෆ࡟ᅄ㓟໬࢜ࢫ࣑࣒࢘᪼⳹࢞ࢫࢆᑟධࡋࠊ┤ὶࢢ࣮ࣟᨺ㟁࡟ࡼࡾࣉࣛࢬ࣐໬ࡉࡏ࡚㔠ᒓ⿕⭷ࢆస〇ࡍࡿࠋNeoc 㟁ᴟࡣ≉ṦᨵⰋࡉࢀࡓᖹ⾜ᖹᯈ㟁ᴟࢆ౑⏝ࡋ࡚࠾ࡾࠊヨᩱࢫࢸ࣮ࢪ඲ᇦ࡛㈇ࢢ࣮ࣟ┦㡿ᇦࡢ㧗ࡉࡀᆒ୍࡜࡞ࡾࠊ࢜ࢫ࣑࢘
࣒ࢆ࢔ࣔࣝࣇ࢓ࢫ㸦㠀ᬗ㉁㸧ࢥ࣮ࢸ࢕ࣥࢢ࡛ࡁࡿࠋࡑࡢ⤖ᯝࠊᙧᡂࡉࢀ
ࡓᑟ㟁⿕⭷࡟ࡼࡾࠊᴟⷧ⭷࡛ࡶヨᩱࡣ㟁Ꮚ⥺ࢲ࣓࣮ࢪࢆཷࡅ࡞ࡃ࡞ࡿࠋ
࢖࣑࢜ࣥࣜࣥࢢ⿦⨨ E-3500 ࡣࠊSEM ヨᩱ࡞࡝࡟ Ar ࢖࢜ࣥࣅ࣮࣒ࢆ↷ᑕࡋ࡚ࠊヨᩱ⾲㠃ࡢཎᏊࢆᙎࡁ㣕ࡤࡍࡇ࡜࡟ࡼࡾࠊᚤ⣽࡞യࡸởࢀࢆ㝖ཤࡋ࡚ከᒙ⭷ࡢ᩿㠃ࢆᚓࡿ࡜ࡁ࡟⏝࠸ࡿᶵჾࠋᛂຊࣞࢫຍᕤࢆ≉㛗࡜ࡍࡿ࢖࢜ࣥࢫࣃࢵࢱࣜࣥࢢ⌧㇟ࢆ⏝࠸ࡿࡇ࡜࡟ࡼࡾࠊヨᩱ⾲㠃ࡢᖹᆠຍᕤ
ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࠋᛂ⏝⠊ᅖࡣᗈࡃࠊ༙ᑟయࢹࣂ࢖ࢫศ㔝ࡸᶵ⬟ᮦᩱศ㔝ࢆጞࡵࠊ࠶ࡽࡺࡿ⏘ᴗศ㔝ࡢ◊✲࣭㛤Ⓨ࠿ࡽရ㉁⟶⌮࡞࡝ከ᪉㠃࡛ά⏝ࡉࢀ࡚࠸ࡿࠋ
⢭ᐦ࢖࣏࢜ࣥࣜࢵࢩࣥࢢ⿦⨨ࡣࠊ࢔ࣝࢦࣥ࢖࢜ࣥࣅ࣮࣒ࢆヨᩱ⾲㠃࡟↷ᑕࡋࠊ࢚ࢵࢳࣥࢢ࡟ࡼࡿྛ✀ヨᩱࡢⷧ⭷໬ࡍࡿ⿦⨨ࠋ࢖࣑࢜ࣥࣜࣥࢢࡸ
㟁ゎ◊☻࡛࢝ࣂ࣮ࡋࡁࢀ࡞࠸㔠ᒓࠊ᭷ᶵ ELࠊ໬ྜ≀༙ᑟయ࡞࡝ࡢ TEM
ほᐹ⏝ⷧ⭷ヨᩱࡢస〇࡟౑⏝ࡉࢀࡿࠋ㉸㡢Ἴࢹ࢕ࢫࢡ࢝ࢵࢱ࣮ࡣ 3 mm ࡢ TEM ࢹ࢕ࢫࢡ࡟཰ࡲࡽ࡞࠸⬤ᛶᮦᩱ࠿ࡽࠊࢹ࢕ࢫࢡ≧ࡲࡓࡣ࢜ࣜࢪࢼࣝᙧ≧࡟ษࡾฟࡍ⿦⨨ࠋᅽ㟁ᛶ⤖ᬗయࢆ฼⏝ࡋ࡚⟄≧ࡢษ᩿ࢶ࣮ࣝࢆ㥑ືࡋࠊ⣽⢏ᗘࡢⅣ໬࣍࢘⣲ࢫ࣮ࣛࣜࢆ฼⏝ࡋ࡚ࠊ40 µm ᮍ‶࠿ࡽ 5 mm ࡲ࡛ࡢཌࡳࡢᮦᩱࢆษࡾᢤࡃࡇ࡜ࡀ
ྍ⬟ࠋᑓ⏝ࡢ཮║ᐇయ㢧ᚤ㙾࡜ X-Y ࢸ࣮ࣈࣝࢆ౑⏝ࡍࡿࡇ࡜࡟ࡼࡾࠊ
┠ⓗࡢ⟠ᡤࢆど㔝ࡢ୰ኸ࡟ࠊ⢭ᐦ࡟఩⨨ྜࢃࡏࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋࢭࣛ
࣑ࢵࢡࢫࡸ༙ᑟయ≀㉁ࡢ࢙࢘ࣁ࣮࠿ࡽ TEM ⏝ࢹ࢕ࢫࢡࢆ⢭ᐦ࡟ᡴࡕᢤ
ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ
ࢲ࢖ࣖࣔࣥࢻ࣡࢖࣮ࣖࢯ࣮ DWS3242 ࡣヨᩱࡢ᩿㠃ほᐹࡸ࢖࣑࢜ࣥࣜࣥ
ࢢࡢ๓ฎ⌮࡜ࡋ࡚⏝࠸ࡽࢀࡿ⿦⨨ࠋヨᩱࡢ⢭ᐦ࡞఩⨨ྜࢃࡏࡀ࡛ࡁࠊษ
᩿㒊఩ࢆ☜ㄆࡍࡿࡇ࡜ࡀྍ⬟ࠋࡘ࡞ࡂ┠ࡢ࡞࠸࣡࢖࣮ࣖࢆ౑⏝ࡋࠊษ᩿᫬ࡢ⇕ࢆỈࡢ౑⏝࡞ࡋ࡛ᨺฟࡋࠊษ᩿ᒌࡶࡓࡲࡾ࡟ࡃ࠸ࡢ࡛ࠊከᒙ⭷ヨᩱࠊ◳ࡉࡢ␗࡞ࡿヨᩱ࡞࡝ࡢ」ྜᮦᩱ࡛ࡶ๭ࢀࡸࢡࣛࢵࢡ࡞ࡃษ᩿࡛ࡁ
ࡿࠋࢹࢪࢱ࣐ࣝ࢖ࢡࣟࢫࢥ࣮ࣉ DVM5000 ࡣ㧗ゎീࣔࢽࢱ࣮ࡀᦚ㍕ࡉࢀࠊ㧗⏬㉁ࣛ࢖ࣈ⾲♧࡛ほᐹࡀ࡛ࡁࡿ⿦⨨࡛࠶ࡿࠋ᭱㐺࡞ほᐹಸ⋡࡟ྍኚ࡛ࡁ
ࡿࢬ࣮࣒ᶵᵓ࡛ࠊᚑ᮶ࡢ㢧ᚤ㙾࡛ࡣ㞴ࡋ࠿ࡗࡓࠊ኱ࡁ࡞ᑐ㇟≀ࡢ㠀◚ቯ᳨ᰝࠊ⾲㠃ほᐹࡶᐜ᫆࡟⾜࠼ࡿࠋࣛ࢖࢝ఏ⤫࡜ᐇ⦼ࡢ㧗࠸ගᏛᶵ⬟࡟ࠊከᶵ⬟࡞ィ ࣭ゎᯒࣔࢪ࣮ࣗࣝࢆᶆ‽ᦚ㍕ࡋࡓ࣮࢜ࣝ࢖ࣥ࣡ࣥࢩࢫࢸ࣒
࡟ࡼࡾࠊ2D ゎᯒࡣࡶࡕࢁࢇࠊ㧗ᗘ࡞ 3D ゎᯒࡶྍ⬟࡛࠶ࡿࠋ

2. ㉮ᰝᆺࣉ࣮ࣟࣈ㢧ᚤ㙾ࢩࢫࢸ࣒㸦SPM㸧࠙ᶵჾศᯒᐊ 6ࠚ㉮ᰝᆺࣉ࣮ࣟࣈ㢧ᚤ㙾㸦SPM㸧ࡣࠊ ᐃヨᩱ࡜᥈㔪㛫࡟ാࡃཎᏊ㛫ຊࡲࡓࡣࢺࣥࢿࣝ㟁ὶࢆ᳨ฟࡍࡿࡇ࡜࡟ࡼࡾࠊヨᩱࡢ⾲㠃ࡢ࣑ࢡࣟ࡞㒊ศࡢᙧ≧ࠊᦶ᧿࡞࡝ࡢ᝟ሗࢆᚓࡿ⿦⨨࡛࠶ࡿࠋࣘࢽࢵࢺ
ࡢ஺᥮࡟ࡼࡾࠊཎᏊ㛫ຊ㢧ᚤ㙾㸦AFM㸧ࠊ㉮ᰝᆺࢺࣥࢿࣝ㢧ᚤ㙾㸦STM㸧ࠊᦶ᧿ຊ㢧ᚤ㙾ࠊ㟁Ẽ໬Ꮫ
AFM࣭STMࠊ࣐࢖ࢡࣟ⢓ᙎᛶ AFM ࡞࡝ࡢ ᐃࡀྍ⬟࡛࠶ࡿࠋ㧗⢭ᗘ኱ᆺࣉ࣮ࣟࣈ㢧ᚤ㙾ࣘࢽࢵࢺ AFM5400L ࡣ 8 ࢖ࣥࢳ(20.32 cm) I
×22 mm㸦ཌࡉ㸧⛬ᗘࡢ኱ࡁࡉࡢヨᩱࡲ࡛ᑐᛂྍ⬟࡛࠶ࡿࠋගᏛ㢧ᚤ㙾ࢆഛ࠼ࠊ⿦⨨ࡢㄪᩚࠊヨᩱࡢ఩⨨ྜࢃࡏࡀᐜ᫆࡟࡛ࡁࡿࠋࢹ࣮ࢱฎ⌮㒊ࡣ㧗㏿ࣇ࣮࢚ࣜኚ᥮㸦FFT㸧ࢆጞࡵ࡜ࡍࡿྛ✀ࡢࣇ࢕ࣝࢱ࣮࠾ࡼࡧ⏬ീゎᯒࣉࣟࢢ࣒ࣛࢆ᭷ࡋࠊどぬ࡟ッ࠼ࡿ 3 ḟඖ⏬ീࢆసᡂࡍࡿࡇ࡜ࡀ࡛ࡁ
ࡿࠋ⎔ቃไᚚᆺࣘࢽࢵࢺ AFM5300E ࡣ 20 mm I ×10 mm㸦ཌࡉ㸧ࡲ࡛ࡢ኱ࡁ
ࡉࡢヨᩱ࡟ᑐᛂྍ⬟࡛ࠊᗘྍኚ㸦-aႏ㸧࠾ࡼࡧ┿✵ୗ࡛ᐃྍ⬟࡞タഛࢆഛ࠼࡚࠸ࡿࠋගᏛ㢧ᚤ㙾ࢆഛ࠼ࠊ⿦⨨ࡢㄪᩚࠊヨᩱࡢ఩⨨ྜࢃࡏࡀᐜ࡛᫆࠶ࡿࠋ㟁Ẽ໬Ꮫ AFM࣭STMࠊ┿✵୰࠾ࡼࡧᗘไᚚศᯒ࡟ࡣ AFM5300E ࢆ⏝࠸ࡿࠋࢹ࣮ࢱฎ⌮㒊ࡣ FFT ࢆጞࡵ࡜ࡍࡿྛ✀ࡢࣇ࢕ࣝࢱ࣮࠾ࡼࡧ⏬ീゎᯒࣉࣟࢢ࣒ࣛࢆ᭷ࡋࠊどぬ࡟ッ࠼ࡿ 3 ḟඖ⏬ീࢆసᡂࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

3. X ⥺ග㟁Ꮚศගศᯒ⿦⨨㸦XPS, ESCA㸧࠙ᶵჾศᯒᐊ 7ࠚ
X ⥺ග㟁Ꮚศගศᯒ㸦XPS㸧ࡣ≀㉁⾲㠃ࡢඖ⣲⤌ᡂࡸ໬Ꮫ⤖ྜ≧ែࡢศᯒ࡜ࡋ࡚᭱ࡶᗈࡃ౑⏝ࡉࢀ࡚࠸ࡿࠋ㉸㧗┿✵୰࡛ࠊບ㉳※࡜ࡋ࡚ AlKDࠊMgKD ࡞࡝ࡢ㌾ X ⥺ࢆヨᩱ࡟↷ᑕࡋࠊᴟ⾲㠃࡟࠶ࡿඖ⣲㸦Li ~ U㸧ࡢ࢖࢜ࣥ໬࡟క࠸ᨺฟࡉࢀࡿග㟁Ꮚࢆ⿵㊊ࡋ࡚ࠊ࢚ࢿࣝࢠ࣮࣭࢔ࢼࣛ࢖ࢨ࣮࡛ ᐃࡍࡿࠋ
Quantera-SXM-GS ࡣᅛయᴟ⾲㠃ࡢᩘཎᏊᒙ࡛ࡢඖ⣲⤌ᡂࡸ໬Ꮫ⤖ྜ≧ែࡢศᯒࡀྍ⬟࡛࠶ࡿࠋศᯒ࡛ࡁࡿヨᩱ⾲㠃࠿ࡽࡢ῝ࡉࡣ 0.5 ~ 5 nm ࡯࡝࡛ࠊ㉮ᰝ㟁Ꮚ㢧ᚤ㙾ࡢ࢚ࢿࣝࢠ࣮ศᩓᆺ X ⥺ศᯒ⿦⨨㸦SEM-EDX㸧࡞࡝࡜ẚ࡭࡚ࠊ≀㉁ࡢᴟ⾲㠃ࡢศᯒ࡟㐺ࡋ࡚࠸ࡿࠋඖ⣲⏤᮶ࡢග㟁Ꮚࢫ࣌ࢡࢺ࡛ࣝ♧ࡉࢀࡿ㟁ᏊࡢཎᏊ᰾࡟ᑐࡍࡿ⤖ྜ࢚ࢿࣝࢠ࣮࡜ᨺฟࡉࢀࡓ
ග㟁Ꮚࡢᙉᗘ࠿ࡽࠊඖ⣲ࡢྠᐃࠊᐃ㔞ศᯒࡀ࡛ࡁࡿ࡯࠿ࠊග㟁Ꮚࣆ࣮ࢡࡢᚤጁ࡞໬Ꮫࢩࣇࢺ࠿ࡽࠊ┠ⓗ࡜ࡍࡿཎᏊࡢ໬Ꮫ⤖ྜ≧ែࡶồࡵࡿࡇ࡜
ࡀ࡛ࡁࡿࠋ



4. 㧗ศゎ⬟㉁㔞ศᯒࢩࢫࢸ࣒࠙ᶵჾศᯒᐊ 1ࠚ㉁㔞ศᯒ㸦Mass Spectrometry㸧࡛ࡣࠊ┠ⓗ࡟ᛂࡌࡓ࢖࢜ࣥ໬ἲ࡟ࡼࡾヨᩱศᏊࢆ࢖࢜ࣥ໬ࡉࡏࠊ⏕ࡌࡓศᏊ࢖࢜ࣥࡸࣇࣛࢢ࣓ࣥࢺ࢖࢜ࣥࡣࠊศᯒ㒊ࡢᵝࠎ࡞௙⤌ࡳ࡟ࡼࡾ㉁㔞ࡀỴᐃࡉࢀࡿࠋศᯒ㒊࡜ࡋ࡚ࡣࠊ஧㔜཰᮰ᆺ㸦Double-focusing㸧ࠊᅄ㔜ᴟᆺ㸦Quadrupole, Q㸧ࠊ㣕⾜᫬㛫ᆺ㸦Time-of-Flight, TOF㸧࡞࡝ࡀ࠶ࡿࠋ5 ✀㢮ࡢ⿦⨨ࡀタ⨨ࡉࢀ࡚࠾ࡾࠊ໬ྜ≀ࡢ✀㢮ࡸ ᐃࡢ┠ⓗู࡟ᶵ✀ࢆ㑅ᢥࡍࡿࡇ࡜ࡀ
࡛ࡁࡿࠋ
ᶵ✀ྡ

㏻⛠

JMS-MSation 700

700

JMS-AMSUN200/GI

.

௙ᵝ
MS
GC/MS
(LC/MS)
GC/MS

GC-Mate II

GC-MateGC/MS

JMS-T100LP

AccuTOFAXIMA-Resonance

AXIMA

MS
LC/MS
MS
MS/MS

࢖࢜ࣥ໬ἲ
EI/CI
FAB
ESI
EI/CI
EI/CI
FAB
ESI
DART
MALDI

᳨ฟἲ

ᐃྍ⬟⠊ᅖ

ศゎ⬟

஧㔜཰᮰

1 ~ 2,400

60,000ᅄ㔜ᴟ

1 ~ 1,000஧㔜཰᮰

1 ~ 1,000> 2,000
5,000ɼ3,000
1,000ɼ500

TOF

1 ~ 1,200

6,000

TOF

100 ~ 12,000
100 ~ 5,000> 8,000

JMS-MSation 700 ࡣ඲࡚ࢥࣥࣆ࣮ࣗࢱไᚚࡉࢀ࡚࠾ࡾࠊ࢖࢜ࣥ※࡞࡝ࡢྛ✀ࣃ࣓࣮ࣛࢱࡢ࣮࢜ࢺࢳ࣮ࣗࢽࣥࢢᶵ⬟ࡀ࠶ࡿࠋヨᩱࡣ㟁Ꮚ࢖࢜ࣥ໬
(electron ionization, EI) ἲࠊ໬Ꮫ࢖࢜ࣥ໬ (chemical ionization, CI) ἲ➼࡛ヨᩱࡀ࢖࢜ࣥ໬ࡉࢀࡿࠋ᳨ฟჾࡣ☢ሙࢭࢡࢱ࣮࡜㟁ሙࢭࢡࢱ࣮ࢆ㓄⨨ࡋࡓ஧㔜཰᮰ᆺ࡛࠶ࡿࠋ㧗ຍ㏿࢖࢜ࣥ※࡜㧗㟁ᅽ༳ຍࢥࣥࣂ࣮ࢪࣙࣥࢲ࢖
ࣀ࣮ࢻᆺ࢖᳨࢜ࣥฟჾ࡟ࡼࡾࠊṇ㈇࢖࢜ࣥࡢ㧗ឤᗘᐃࡀྍ⬟࡛ࠊ㧗㉁㔞㡿ᇦ࡟࠾࠸࡚ࡶṇ☜࡟㉁㔞ࢆỴᐃ࡛ࡁࡿࠋ
Gcmate II ࡣᯒ㒊࡟஧㔜཰᮰ගᏛ⣔ࢆࡶࡘࠊ඲⮬ືไᚚࡢ࣮ࣝࢸ࢕ࣥศ
ᯒࢆᑐ㇟࡜ࡋࡓ༟ୖᆺࡢ GC/MS ⿦⨨࡛࠶ࡿࠋᐃ㔞ศᯒ࣭ᐃᛶศᯒࡢࡳ
࡞ࡽࡎࠊ⢭ᐦ㉁㔞

ᐃࢆ⾜࠼ࡿᛶ⬟ࢆഛ࠼࡚࠸ࡿࠋ㏿㟁ᅽ 2.5 kV ࡛

1 ~ 1,000 ࢲࣝࢺࣥࠊ 1.25 kV ࡛ 1 ~ 2,000 ࢲࣝࢺࣥᐃ㉁㔞⠊ᅖࡣࠊຍ

࡛ࠊศゎ⬟ࡣ 4 ẁษࡾ᭰࠼࡛࠶ࡿࠋ࢖࢜ࣥ※ࡣ EI, CI, FAB ࡛࠶ࡿࠋAMSUN200 (K9) ࡣ࢞ࢫࢡ࣐ࣟࢺࢢࣛࣇ㸦GC㸧ࡀヨᩱᑟධ㒊࡜ࡋ࡚┤⤖ࡉࢀࡓࠊᅄ㔜ᴟᆺࡢ༟ୖ GC/MS ⿦⨨࡛࠶ࡿࠋᅄ㔜ᴟᆺࡢศᯒ㒊ࡣ 4ᮏࡢ㟁ᴟࣟࢵࢻ࠿ࡽ࡞ࡾࠊ┤ὶ㟁ᅽ࡜஺ὶ㟁ᅽࢆ࠿ࡅࡿࡇ࡜࡟ࡼࡾࠊ≉ᐃࡢ m/z ್ࡢ࢖࢜ࣥࡔࡅࢆ㏻㐣ࡉࡏࡿ㟁ሙࢆᙧᡂࡍࡿࠋᐃྍ⬟࡞㉁㔞⠊ᅖࡣ஺ὶ㟁ᅽ࡛Ỵࡲࡿࡢ࡛ࠊ┤ὶ㟁ᅽ࡜஺ὶ㟁ᅽࡢẚࢆ୍ᐃ࡟ಖ
ࡕࠊ஺ὶ㟁ᅽࢆ┤⥺ⓗ࡟ኚ໬ࡉࡏࡿࡇ࡜࡟ࡼࡾࠊ≉ᐃࡢ࢖࢜ࣥࢆ㏻㐣ࡉࡏศ㞳ࡍࡿࠋ

JMS-T100LP (AccuTOF LC-plus) ࡛ࡣࠊESI ἲ࡟ࡼࡾ㧗ศᏊࢆࣇࣛࢢ࣓
ࣥࢺ໬ࡍࡿࡇ࡜࡞ࡃ࢖࢜ࣥ໬ࡋศᯒ࡛ࡁࡿࠋ୍᪉ࠊDART ἲࢆ⏝࠸ࡿ࡜ࠊపᴟᛶ࠿ࡽ㧗ᴟᛶࡲ࡛ࡢᖜᗈ࠸ヨᩱࢆ๓ฎ⌮ࡍࡿࡇ࡜࡞ࡋ࡟ศᯒࡀ
ྍ⬟࡛࠶ࡿࠋDART ࡟ࡼࡿ࢖࢜ࣥ໬ࡣບ㉳≧ែࡢ࣒࣊ࣜ࢘ࡀ኱Ẽ࢞ࢫ࠾ࡼࡧヨᩱ࡜┦஫స⏝ࡍࡿࡇ࡜࡟ᇶ࡙࠸࡚࠾ࡾࠊ㏻ᖖࡢศᯒᶵჾ࡛ࡣᢅ࠺
ࡇ࡜ࡢ࡛ࡁ࡞࠸ࠊ୙ᐃᙧࡢヨᩱࡸởࢀࡓヨᩱࡶࡑࡢࡲࡲศᯒ࡛ࡁࡿࡇ࡜
ࡀ≉ᚩ࡛࠶ࡿࠋAXIMA-Resonance ࡛⏝࠸ࡿ MALDI ἲࡣ௦⾲ⓗ࡞ࢯࣇࢺ࢖࢜ࣥ໬ἲ
࡛ࠊ⏕య㧗ศᏊ㸦࣌ࣉࢳࢻࡸ⢾㉁㸧ࡢ㉁㔞ศᯒࡀ࡛ࡁࡿࠋ࣐ࢺࣜࢵࢡࢫ
ヨᩱࡣࠊἼ㛗 337 nm ࡢ❅⣲࣮ࣞࢨ࣮ග࡟ࡼࡾࠊࡑࡢ᭱⾲㠃㸦~ 100nm㸧ࡀᩘ nsec ࡛ᛴ㏿ຍ⇕ࡉࢀࠊẼ໬ࡉࢀࡿࠋᅄ㔜ᴟ࢖࢜ࣥࢺࣛࢵࣉ
㸦QIT㸧ࢆ౑⏝ࡋ࡚࠾ࡾࠊ࢖࢜ࣥ໬᫬࡛ࡢึᮇ࢚ࢿࣝࢠ࣮ࡢࡤࡽࡘࡁ࡟
ࡼࡿ⢭ᗘࡢపୗࢆ㜵࠸࡛࠸ࡿࠋࡲࡓࠊQIT ࡟ࡼࡾヨᩱࡢ㐃⥆ⓗ࡞㛤⿣ࡀྍ⬟࡜࡞ࡾࠊ⢾㉁࡞࡝ࡢᵓ㐀ゎᯒ࡟ᚲせ࡞ከẁ㝵 MS ࢫ࣌ࢡࢺࣝࡀᚓࡽ
ࢀࡿࠋ
Agilent 1100 series ࡢ MS-52011LC ࡣࠊ᳨ฟჾ࡜ࡋ࡚ࠊ⣸እྍどගศග᳨ฟჾ㸦190 ~ 600 nm㸧ࠊ⺯ග᳨ฟჾ㸦280 ~ 900 nm㸧ࠊ♧ᕪᒅᢡ⋡᳨ฟჾ㸦ᒅᢡ⋡ 1.00 ~ 1.75ࠊᐊ

㸩5 ~ 55ºC ࡢ⠊ᅖ୍࡛ᐃ࡟タᐃྍ㸧ࢆഛ࠼࡚࠾ࡾࠊ࡯࡜ࢇ࡝ࡢ᭷ᶵ໬ྜ≀ࡣ㧗ឤᗘ᳨࡛ฟ࡛ࡁࡿࠋࡲࡓࠊAccuTOF࡟᥋⥆ࡋ LC/MS ࡜ࡋ࡚ࠊ㉁㔞ศᯒࡢࡓࡵࡢ┠ⓗ≀㉁ࡢศ㞳ࡀྍ⬟࡛࠶ࡿࠋ

AXIMA-Resonance ࡜࣌࢔࡛౑⏝ࡍࡿࡓࡵࠊnanoLC ⮬యࡣ᳨ฟჾࢆᣢࡓ
࡞࠸ࠋAXIMA-nanoLC ࡢศᯒᑐ㇟࡜࡞ࡿࢱࣥࣃࢡ㉁ࡸ࣌ࣉࢳࢻ᳨యࡣࠊ
ᴟࡵ࡚ᚤ㔞࡞ࡇ࡜ࡀከࡃࠊMS ࡛ࡢឤᗘྥୖࡢࡓࡵࠊᚤ㔞ὶ㔞ࡀ⢭ᐦ࡟ไᚚࡉࢀࡓࣁ࢖࢚ࣥࢻ HPLC ࡛࠶ࡿࠋὶ㔞⠊ᅖࡣ 0 ~ 5,000 nL/min㸦1 nL
step㸧࡛ࠊ㧗ᅽࢢࣛࢪ࢚ࣥࢺ࣮ࣔࢻ㸦ࢫࢸࢵࣉࠊࣜࢽ࢔㸧ࡣከẁ࡛タᐃࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
JASCO EXTREMA ࡣࠊ࣏ࣥࣉ࡟పᅽࢢࣛࢪ࢚ࣥࢺ࣏ࣥࣉࠊ᳨ฟჾ࡜ࡋ࡚ PDA ᳨ฟჾ㸦190 ~ 900 nm㸧ࠊ⺯ග᳨ฟჾ㸦200 ~ 900 nm㸧ࢆഛ࠼࡚࠾ࡾࠊ㧗ឤᗘ࡞᳨ฟࡀ࡛ࡁࡿࠋࡲࡓࠊ࣮࢜ࢺࢧࣥࣉ࣮ࣛࢆ౑⏝ࡋࡓ⮬ືᐃࡀྍ⬟࡛࠶ࡿࠋ᭦࡟㐲㝸⏝ࡢࢯࣇࢺ࢙࢘࢔࡟ࡼࡾ

ᐃ≧ἣࢆ㐲㝸ᆅ࠿ࡽ☜ㄆࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋ

5. ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦FT-NMR㸧࠙ᶵჾศᯒᐊ 2ࠚ᰾☢Ẽඹ㬆㸦nuclear magnetic resonance, NMR㸧ࡣศᏊࡢᵓ㐀ࡸ≀ᛶࢆ▱ࡿ᭱ࡶ㔜せ࡞ศᯒἲࡢ୍ࡘ
࡛ࠊ㉸㟁ᑟ☢▼࡟ࡼࡿ㧗☢ሙࡀᐇ⌧ࡉࢀࠊࣇ࣮࢚ࣜኚ᥮ἲ࠾ࡼࡧࢥࣥࣆ࣮ࣗࢱ࡞࡝ࡢ㐍Ṍ࡟ࡼࡾࠊ✀ࠎࡢศᏊࢆᐜ᫆࡟࠿ࡘ㧗⢭ᗘ࡟ศᯒࡍࡿࡇ࡜ࡀྍ⬟࡟࡞ࡗࡓࠋᰗᡞᆅ༊࡟ࡣ 3 ྎࡢ FT-NMR ࡀタ⨨ࡉࢀ࡚࠸ࡿࠋ࠸ࡎࢀࡢᶵ✀ࡶ࣮࢜ࢺࢳ࣮ࣗࣥࣘࢽࢵࢺࢆࢹࣇ࢛ࣝࢺ࡜ࡋ࡚タᐃࡋ࡚࠾ࡾࠊ᰾✀ࡢษ᭰࠼ࠊ୪ࡧ࡟ࠊ ᗘࡸ⁐፹ࡢ㐪࠸࡟ࡼࡾᚲせ࡜࡞ࡿࣉ࣮ࣟࣈࡢࢳ࣮ࣗࢽࣥࢢࡸ࣐ࢵࢳࣥࢢࡢ᧯స

ࡀࢥࣥࣆ࣮ࣗࢱ࡟ࡼࡾ⮬ືⓗ࡟ᐇ⾜ࡉࢀࡿࠋࡲࡓࠊECA500 ࡣ࣮࢜ࢺࢳࣗࣥࣉ࣮ࣟࣈࡔࡅ࡛ࡣ࡞ࡃ࢖
ࣥࣂ࣮ࢫࣉ࣮ࣟࣈ࡜ᅛయࣉ࣮ࣟࣈࢆ⿦ഛࡋ࡚࠸ࡿࡓࡵࠊᅛయࢧࣥࣉࣝࡢ ᐃࡀྍ⬟࡛࠶ࡿࠋ
ECA500 ࡛ࡣࠊ㏻ᖖ

ᐃ㸦1H㸪13C㸪DEPT㸪COSY㸧ࡢࡳ࡞ࡽࡎࠊࣃ

ࣝࢫ☢ሙ໙㓄ἲ㸦Pulsed Field Gradient, PFG㸧ࢆ⏝࠸࡚ࠊຠ⋡ⓗ࡞ 2
ḟඖ NMRᵝࠎ࡞ᐃࠊ୪ࡧ࡟ࠊHMBCࠊHMQCࠊTOCSYࠊDOSY ࢆྵࡴᐃᡭἲࢆᐇ᪋ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋᮏ⿦⨨ࡣ࢖ࣥࣂ࣮ࢫࣉࣟ

࣮ࣈࢆ⿦ഛࡋ࡚࠾ࡾࠊ1H ࡟≉໬ࡋࡓឤᗘࡢ㧗࠸ࡉࡽ࡟ࠊᅛయ NMRᐃࡶྍ⬟࡛࠶ࡿࠋ

ᐃࣘࢽࢵࢺ NM-93030CPM ࡀ⿦ഛ࡛ࡁࠊᅛయ໬

Ꮫࠊ⏕య㧗ศᏊศ㔝࡟ࡶᛂ⏝ྍ⬟࡛࠶ࡿࠋ㉸ఏᑟ࣐ࢢࢿࢵࢺᇶ‽☢
ሙࡣ 11.74 T ࡛࠶ࡿࠋECZ600R/M1 ࡣ㧗ឤᗘࠊ㧗ศゎ⬟ࢆ᭷ࡋ㉸ఏᑟ࣐ࢢࢿࢵࢺᇶ‽☢ሙ
ࡣ 14.09 T ࡛࠶ࡿࠋᮏᏛࡢ NMR ࡟࠾࠸࡚ึࡵ࡚㐲㝸⮬ືᐃ࡟ᑐᛂࡋࡓᅛᾮව⏝ NMR ࡛࠶ࡿࠋࡇࡢᵓᡂ࡟ࡼࡾᏛෆࡢྛᏛ㒊ࡢㅮ⩏ᐇ⩦࡟ά⏝ࡉࢀ࡚࠸ࡿࠋᾮయࣉ࣮ࣟࣈ; ROYAL ࣉ࣮ࣟࣈ HFX ࡣ ECA,ECX ࣮࢜ࢺࢳ࣮ࣗࢽࣥࢢࣉ࣮ࣟࣈ࡟ᑐࡋ⣙ 2 ಸࡢឤᗘࢆ᭷ࡋࠊ2 㔜ඹ㬆࡜ 3 㔜ඹ㬆ࢆ⮬ືⓗ࡟ษ᭰࠼ྍ⬟࡞ࣉ࣮ࣟࣈ࡛࠶ࡿࠋ౛࠼ࡤ 13C
ᐃ᫬࡟ 1H, 19F ᰾ࢆྠ᫬↷ᑕࡋࢹ࢝ࢵࣉࣜࣥࢢࡋࡓ

ᐃࡀྍ⬟࡛࠶

ࡿࠋࡲࡓࠊ3.2 mm ᅛయ࣮࢜ࢺ MAS ࣉ࣮ࣟࣈࡣ࣮࢜ࢺࢧࣥࣉࣝࢳ࢙ࣥ ࢪ࣮ࣕ࡜࣮࢜ࢺࢳ࣮ࣗࢽࣥࢢࠊ࣮࢜ࢺ MAS ࡟ࡼࡿ⮬ືⓗ࡞ᐃࡀྍ ⬟࡛࠶ࡿࠋ
ECX-400P ࡛ࡣࠊ㏻ᖖ

ᐃ㸦1H㸪13C㸪DEPT㸪COSY㸧ࡢࡳ࡞ࡽࡎࠊ

ࣃࣝࢫ☢ሙ໙㓄ἲ㸦Pulsed Field Gradient, PFG㸧ࢆ⏝࠸࡚ࠊຠ⋡ⓗ࡞ 2
ḟඖ NMRᵝࠎ࡞ᐃࠊ୪ࡧ࡟ࠊHMBCࠊHMQCࠊTOCSYࠊDOSY ࢆྵࡴᐃᡭἲࢆᐇ᪋ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ㉸ఏᑟ࣐ࢢࢿࢵࢺࡢᇶ‽☢ሙࡸ☢ሙࡢㄪᩚ⢭ᗘࡣ␗࡞ࡿࡀࠊECA-600 ࡜ྠᵝ࡟ࠊᵝࠎ࡞ᐃᡭἲࢆᐇ᪋ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ㉸ఏᑟ࣐ࢢࢿࢵࢺᇶ‽☢ሙࡣ 9.39 T࡛࠶ࡿࠋ

6. 㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦ESR㸧࠙ᶵჾศᯒᐊ 7ࠚ㟁Ꮚࢫࣆࣥඹ㬆㸦Electron Spin Resonance㸹ESR㸧 ⿦⨨ࡣࠊヨᩱࡢᙧ≧㸦ᾮయࠊẼయࠊᅛయ㸧࡟ᙳ㡪ࡉࢀࡿࡇ࡜࡞ࡃࠊ㠀◚ቯ࡛ࠊ㑅ᢥⓗ࡟ࣇࣜ㸫ࣛࢪ࢝ࣝࢆ ᐃ࡛ࡁࡿ၏୍ࡢᡭẁ࡛࠶ࡿࠋESR ࡢᐃᑐ㇟ࡣࠊ୙ᑐ㟁Ꮚ㸦unpaired electron㸧࡛࠶ࡿࡓࡵࠊ୙ᑐ㟁Ꮚࢆᣢࡘ≀㉁ࡣࡍ࡭࡚ ᐃྍ⬟࡛࠶ࡿࠋ㕲ࡸ㖡࡞࡝ࡢ㔠ᒓ࢖࢜ࣥࡣࠊྂࡃ࠿ࡽࡑࢀࡽࢆྵࡴ㘒యࡢᵓ㐀ゎᯒࡀ⾜ࢃࢀ࡚ࡁࡓࡀࠊࡇࢀࡽ
ࡢ㔠ᒓ࢖࢜ࣥࢆྵࡴࢱࣥࣃࢡ㉁ࡶ ᐃྍ⬟࡛࠶ࡾࠊ㓝⣲࡞࡝ࡢ⏕యヨᩱࡢᵓ㐀ᶵ⬟ゎᯒ࡟ಀࡿ◊✲࡟ࡶᗈࡃ⏝࠸ࡽࢀࡿࡼ࠺࡟࡞ࡗࡓࠋ

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JES-FA100 ࡣࠊࣇࣝࢥࣥࣆ࣮ࣗࢱࢥࣥࢺ࣮ࣟࣝ㸭Windows ࣮࢜࣌ࣞࢩࣙ
ࣥࡀྍ⬟࡛ࠊࡇࢀࡲ࡛ࡣࠊඹ᣺࿘Ἴᩘࢆ᥈ࡋࠊࣇ࢙࣮ࢬ࡜࢝ࢵࣉࣜࣥࢢ
࢔࢖ࣜࢫࢆ࣐࢖ࢡࣟἼࡢࣃ࣮࣡ࢆኚ࠼࡞ࡀࡽㄪᩚࡋ࡚࠸ࡓࡀࠊᮏ⿦⨨࡛ࡣࢪࣕࢫࢺ࢝ࢵࣉࣜࣥࢢࡢࡓࡵࡢ࣐࢖ࢡࣟἼㄪᩚࡣ "AUTOTUNE" ࣎ࢱ୍ࣥࡘ࡛᏶஢࡛ࡁࡿࠋ࣮࢜࣌ࣞࢩࣙࣥ⏬㠃ࡣࢫ࣌ࢡࢺࣝྲྀࡾࡇࡳ⏬㠃࡜ࢹ࣮ࢱฎ⌮⏬㠃ࡢ 2 ࡘ࡛ᵓᡂࡉࢀ࡚࠸ࡿࠋESRᐃ㸫⮬ືಖᏑࠊ

ᐃᐃ᮲௳ࡢ࡯࠿ࠊ㐃⥆ᗘタᐃࠊࡑࡢ௚ࡢ᮲௳ࢆྛ࢘࢕ࣥࢻ࢘࠿ࡽタᐃ࡛ࡁࡿࠋ

7. ㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ⿦⨨㸦ICP-AES㸧࠙ᶵჾศᯒᐊ 7ࠚ㟁Ꮚᮦᩱࠊࢭ࣑ࣛࢵࢡࢫࠊ㉸ఏᑟᮦᩱ➼ࡢඛ➃ᮦᩱࡸ⏕యヨᩱ୰࡟Ꮡᅾࡍࡿᚤ㔞ඖ⣲ࠊỈࠊᅵተࠊ኱Ẽ࡞࡝⎔ቃ୰࡟Ꮡᅾࡍࡿඖ⣲ࢆゎ᫂ࡍࡿࡇ࡜ࡀࠊ≀㉁ࡢㅖᛶ㉁ࢆ◊✲ࡍࡿୖ࡛ࡋࡤࡋࡤᚲせ࡜࡞ࡿࠋㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ㸦Inductively Coupled Plasma-Atomic Emission Spectrometry, ICPAES㸧ࡣࠊࡇࡢࡼ࠺࡞┠ⓗ࡟ᑐࡋ࡚᭷⏝࡛࠶ࡾࠊከඖ⣲㸦Ṥ࡝ࡢ㔠ᒓඖ⣲ࠊ୪ࡧ࡟ࠊ࣍࢘⣲ࠊⅣ⣲ࠊࢣ࢖⣲ࠊࣜࣥࠊ◲㯤࡞࡝ࡢᗄࡘ࠿ࡢ㠀㔠ᒓඖ⣲ࢆྵࡵࡓ 70 ௨ୖࡢඖ⣲㸧ࢆྠ᫬࡟ᴟᚤ㔞࠿ࡽ㧗⃰ᗘࡲ࡛ࡢᗈ࠸⃰ᗘ⠊ᅖ࡟Ώࡗ࡚ࠊᐃᛶⓗ࠿ࡘᐃ㔞ⓗ࡟ศᯒࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋICP ࡜ࡣࠊAr ࡞࡝ࡢᕼ࢞ࢫ࡟㧗㟁ᅽࢆ࠿ࡅ࡚ࣉࣛࢬ࣐໬ࡋࠊ㧗࿘Ἴᩘࡢኚື☢ሙ࡟ࡼࡾࣉࣛࢬ࣐ෆ㒊࡟㐣㟁ὶࢆ⏕ࡌࡉࡏ࡚ᚓࡽࢀࡿ㧗 ࣉࣛࢬ࣐ࡢࡇ࡜࡛࠶ࡿࠋULTIMA2 ࡣ Ar ࡢ㧗࿘Ἴㄏᑟ⤖ྜࣉࣛࢬ࣐ࢆບ㉳※࡜ࡋ࡚࠾ࡾࠊ↓ᶵ≀ࡸ᭷ᶵ≀୰ࡢ 75 ඖ⣲ࢆྠ᫬࡟ᐃ࡛ࡁࡿ㉸㧗ឤᗘඖ⣲ศᯒ⿦⨨࡛࠶ࡿࠋ⮬ᕫ྾཰ࡀṤ࡝࡞ࡃࠊࢲ࢖ࢼ࣑ࢵࢡࣞࣥࢪࡣ 106 ࡜ᗈ࠸ࡢ࡛ࠊヨᩱ୰ࡢ୺ᡂศ࠿ࡽᴟᚤ㔞ᡂศࡲ࡛ศᯒࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋヨᩱࡶᑡ࡞ࡃ࡚ࡍࡳࠊ1 ศ㛫ᙜࡓࡾ 1 ml ࡢὀධ㔞࡟࡚ 2 ศ⛬ᗘ࡛ࠊඖ⣲ࡢ✀㢮࡜ྛࠎࡢྵ᭷㔞ࢆศᯒ࡛ࡁࡿࠋᮏ⿦⨨࡟ࡣࠊ㉸⣧Ỉ〇㐀⿦⨨㸦Advantec
RFD250NB㸧࡜࣐࢖ࢡࣟἼศᯒ๓ฎ⌮⿦⨨㸦MARS6㸧ࡀ௜ᒓࡋ࡚࠸ࡿࠋMARS6 ࡣ࣐࢖ࢡࣟἼࢆ฼⏝ࡋࠊᐦ㛢ᐜჾෆ࡛ᅛయヨᩱࢆ㓟ศゎࡋࡓࡾࠊ㧗࣭㧗ᅽୗ࡛᭷ᶵྜᡂࡋࡓࡾࡍࡿࡓࡵࡢᶵჾ࡛࠶ࡿࠋᮏ⿦⨨࡟ࡣ㠀᥋ゐ 

ᗘࢭࣥࢧ࣮ࡀᦚ㍕ࡉࢀ࡚࠾ࡾࠊ࣡࢖ࣖࣞࢫ iWave ࢸࢡࣀࣟࢪ࣮ࢆ⏝࠸ࡿࡇ࡜࡛ࠊᐜჾ࡛ࡣ࡞ࡃࠊヨᩱ⁐ᾮࡢࡿࡇ࡜ࡀ࡛ࡁࡿࠋṇ☜࡞ィ

ᗘࢆ┤᥋ィ

ࡍ

࡟ࡼࡾࠊ㓟ศゎࣉࣟࢭࢫࡸ᭷ᶵྜᡂ཯ᛂࢆ

⢭ᐦ࡟ไᚚࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋ

8. Ἴ㛗ศᩓᆺ⺯ග㹖⥺ศᯒ⿦⨨㸦XRF㸧࠙ᶵჾศᯒᐊ 7ࠚ
ヨᩱ࡟ X ⥺ࢆ↷ᑕࡍࡿ࡜ࠊࡑࡢ≀㉁ࢆᵓᡂࡍࡿඖ⣲ࡢෆẆࡢ㟁Ꮚࡣ୍ᐃ௨ୖࡢ࢚ࢿࣝࢠ࣮ࢆࡶࡘ X⥺࡟ࡼࡾບ㉳ࡉࢀࠊ㌶㐨࡟✵Ꮝࡀ⏕ࡌࡿࠋ⺯ග X ⥺㸦X-ray Fluorescence, XRF㸧࡜ࡣࠊࡑࡢ㌶㐨࡬እẆࡢ㟁Ꮚࡀ㑄⛣ࡍࡿ㝿࡟ᨺฟࡉࢀࡿ≉ᛶ X ⥺ࡢࡇ࡜ࢆ࠸࠺ࠋࡑࡢἼ㛗ࡣඖ⣲≉᭷ࡢෆẆ࡜እẆࡢ࢚ࢿࣝࢠ࣮ᕪ࡟ᑐᛂࡋ࡚࠸ࡿࠋἼ㛗ศᩓᆺ XRF ⿦⨨࡛ࡣࠊ」ᩘࡢศග⤖ᬗࢆษࡾ᭰࠼ࡽࢀࡿ᳨ฟჾࢆ⏝࠸࡚ࠊ≉ᐃἼ㛗ࡢ⺯ගࢆศᯒࡍࡿࠋ㏻ᖖࠊ ᐃྍ⬟ඖ⣲ࡣ B ࠿ࡽ U ࡛࠶ࡾࠊ10 eV ⛬ᗘࡢ࢚ࢿࣝࢠ࣮ศ
ゎ⬟ࢆ᭷ࡍࡿࠋ

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S8 TIGER ࡣࠊ⢊ᮎࠊⷧ⭷ࠊᶵ⬟ᮦᩱ࡞࡝࡟ X ⥺ࢆ↷ᑕࡋ࡚ࠊ≀㉁࠿ࡽ
ᨺฟࡉࢀࡿ⺯ග X ⥺ࢆᐃࡋࠊྵࡲࢀࡿඖ⣲࡟ࡘ࠸࡚ᐃᛶ࣭ᐃ㔞ࢆ⾜࠺⿦⨨࡛࠶ࡿࠋ㍍ඖ⣲࠿ࡽ㔜ඖ⣲ࡲ࡛ࠊᅛయ࣭ᾮయ࣭⢊యࡢ≧ែ࡛ࠊppbࣞ࣋ࣝࡲ࡛ᐃࡀྍ⬟࡛࠶ࡿࠋࢦࢽ࣓࣮࢜ࢱࡢゅᗘ෌⌧ᛶ㸦± 0.0001º㸧ࡀⰋࡃࠊ࠿ࡘ㧗㏿࡛࠶ࡾ㸦ࢫ࢟ࣕࣥࢫࣆ࣮ࢻ 1,2000º/min㸧ࠊඃࢀࡓศᯒ
⢭ᗘࢆ᭷ࡍࡿࠋ᳨㔞⥺ࡀ࡞࠸ᮍ▱ヨᩱࡢศᯒ࡟ࡣࠊࣇ࢓ࣥࢲ࣓ࣥࢱࣝࣃ
࣓࣮ࣛࢱ࣮ࢯࣇࢺ࢙࢘࢔࡟ࡼࡿ᭱㏿ 2 ศࡢࢹࢪࢱࣝࢫ࢟ࣕࣥࢫࢡ࣮ࣜ
ࢽࣥࢢࡀ࡛ࡁࡿࠋ

9. ᭷ᶵᚤ㔞ඖ⣲ศᯒࢩࢫࢸ࣒㸦OEA㸧࠙ᶵჾศᯒᐊ 3ࠚ᭷ᶵ≀ࡣ᏶඲࡟⇞↝ศゎࡋ࡚㑏ඖ㖡ࢆ㏻㐣ࡍࡿ࡜ࠊH2OࠊCO2ࠊN2 ࢞ࢫ࡜࡞ࡿࠋ᭷ᶵᚤ㔞ඖ⣲ศᯒ⿦⨨㸦Organic Element Analyzer, OEA㸧ࡣࠊ᏶඲⇞↝࡟ࡼࡾ⏕ᡂࡋࡓ H2OࠊCO2ࠊN2 ࢞ࢫࢆࡑࢀࡒࢀ⇕ఏᑟᗘ᳨ฟჾ࡛ᐃ㔞ࡋ࡚ࠊヨᩱࡢᵓᡂඖ⣲ C࣭H࣭N 㔞ࢆ ᐃࡍࡿ⿦⨨࡛࠶ࡿࠋࡑࡢศᯒ⤖ᯝ࠿ࡽ໬ྜ≀ࡢ⣧ᗘࡸ⤌ᡂ࡞࡝ࢆồࡵࠊ໬ྜ≀ࡢྠᐃࢆ⾜࠺ࠋᚤ㔞ඖ⣲ศᯒࡣ໬Ꮫࠊ་Ꮫࠊ⸆Ꮫཬࡧ㎰Ꮫ࡞࡝࡛ᗈࡃ฼⏝ࡉࢀ࡚࠸ࡿࠋ
ᮏࢩࢫࢸ࣒ࡣ CHN Analyzer MICRO CORDER JM-10ࠊ◲㯤ศᯒࣘࢽࢵ
ࢺ JMSU10 ࠾ࡼࡧ࣮࢜ࢺࢧࣥࣉ࣮ࣛ JMA102 ࠿ࡽ࡞ࡿࠋJM-10 ࡣᅛయ࠿ࡽᾮయࡲ࡛ࠊᖜᗈ࠸ศ㔝࡛౑⏝ྍ⬟࡞⿦⨨࡛ࠊ᏶඲⇞↝࡟ࡼࡾ⏕ᡂࡋࡓ H2OࠊCO2ࠊN2 ࢞ࢫࢆࠊࡑࢀࡒࢀ⊂❧ࡋࡓ⇕ఏᑟᗘ᳨ฟჾ࡛ᐃ㔞ࡋ࡚ࠊヨᩱࡢᵓᡂඖ⣲ CࠊHࠊN ࡢẚ⋡ࢆỴᐃࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ◲㯤ࡣᑓ⏝ࡢ JMSU10 ࡢ⇞↝⟶࡜㑏ඖ⟶ࢆ⏝࠸࡚ᐃࡍࡿࠋJMA102 ࡟ࡼࡾ 20᳨యࡢ㐃⥆ศᯒࡀྍ⬟࡛࠶ࡿࠋ10. ㉸㧗㏿ᗘ⌧㇟ゎᯒࢩࢫࢸ࣒࠙ࢭ࣑ࢼ࣮ᐊࠚ
ᮏࢩࢫࢸ࣒࡛ࡣࠊࢼࣀ⛊㸦ns㸧࣮࢜ࢲ࣮ࡲ࡛ࡢ⮬↛⏺ࡢᵝࠎ࡞㉸㧗㏿ᗘ⌧㇟ࠊࡓ࡜࠼ࡤ✄ጔࡢఏ᧛㐣⛬ࠊᮦᩱࡢ◚ቯ㐣⛬ࠊ஘ὶࡢⓎ⏕㐣⛬ࠊࡉࡽ࡟ࡣ࣑ࢡࣟ࡞࡛ࣞ࣋ࣝࡢ༙ᑟయ୰ࡢ㟁Ꮚ-ṇᏍ཯ᛂ࡞࡝
ࢆࠊගࡶࡋࡃࡣ⇕࡟ࡼࡗ࡚ࠊ࠶ࡿ࠸ࡣࣇ࢛ࢺ࣑ࣝࢿࢭࣥࢫ⌧㇟ࢆ㏻ࡋ࡚ࣜ࢔ࣝࢱ࢖࣒࡛㏣㊧ࡋࠊゎᯒࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ኱ࡁࡃศࡅ࡚㧗㏿ᗘ᧜ᙳ࣓࣭࢝ࣛࣅࢹ࢜ࢩࢫࢸ࣒࡜㧗㏿ᗘ㉥እ⥺࣓࢝ࣛࡢ 2 ࡘࡢࢩࢫࢸ࣒࠿ࡽᵓᡂࡉࢀ࡚࠸ࡿࠋᙜศ㔝࡟ࡣࠊ㉸㧗㏿ᗘ᧜ᙳ⿦⨨ HyperVision HPV-2Aࠊỗ⏝㧗㏿ᗘ᧜ᙳ⿦⨨ MEMECAM GX-8ࠊ㧗㏿ᗘ㉥እ⥺࣓࢝ࣛ SC7500TEC ࡞࡝ࡀ࠶ࡾࠊᚲせ࡟ᛂࡌ࡚ࠊ1 ᪥༢఩࡛᧜ᙳ
ᶵჾ࡜୕⬮ࢆ㈚ࡋฟࡋ࡚࠸ࡿࠋ

㧗㏿ᗘ᧜ᙳ࣓࣭࢝ࣛࣅࢹ࢜ࢩࢫࢸ࣒ HyperVision HPV-2A ࡣ᭱኱᧜ᙳ㏿
ᗘ 100 ୓ࢥ࣐/⛊ࡢ᫬㛫ศゎ⬟ࢆᣢࡕࠊ᭱኱ 100 ᯛࡢ⏬ീࢆグ㘓ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋゎീᗘࡣ 312 × 260 ࡢ 8.1 ୓⏬⣲ࠋࣔࣀࢡࣟ 10 bitࠋ᧜ീࢹ࣮ࢱ
ࡣ USB ࢆ㏻ࡋ࡚ࠊBMPࠊAVIࠊJPEGࠊTIFF format ࡛ฟຊ࡛ࡁࡿࠋ௵ពࡢ
ࣇ࣮࣒ࣞ࡟ࢺ࣮ࣜ࢞ಙྕࢆධࢀࡿࡇ࡜ࡀ࡛ࡁࠊ㉸㧗㏿ࡢ⌧㇟ࡢ᧜ീ࡟㐺
ࡋ࡚࠸ࡿࠋ



MEMECAM GX-8 ࡣࠊ1280 × 1024 ࡢゎീᗘ࡛ 2916 ࢥ࣐/⛊ࡢ᧜ᙳࡀྍ
⬟ࠋ1024×768 ࡢゎീᗘ࡛ 4628 ࢥ࣐/⛊ࠊ᭱኱࡛ 60 ୓ࢥ࣐/⛊ࡲ࡛᧜ᙳྍ
⬟㸦16 × 4 ࣆࢡࢭࣝ㸧ࠋࣔࣀࢡ࡛ࣟឤᗘࡣ ISO20000ࠋࣇࣝࣇ࣮࣒࡛ࣞࡢ
᭱኱᧜ീࢥ࣐ᩘࡣ⣙ 5000 ᯛࠋF ࣐࢘ࣥࢺ࠾ࡼࡧ C ࣐࢘ࣥࢺࡢࣞࣥࢬࡀ
⿦╔ྍ⬟ࠋࢺ࣮࣮ࣜ࢞ࣔࢻࢆ㐺ษ࡟タᐃࡍࡿࡇ࡜࡛ࠊࣅࢹ࣓࢜࢝ࣛឤぬ࡛⡆༢࡟㧗㏿⌧㇟ࢆᤊ࠼ࡿࡇ࡜ࡀ࡛ࡁࡿࠋPC ࡞ࡋ࡛ࡢࣜࣔࢥࣥ᧯సࡶ
ྍ⬟࡛ࠊእ㒊ࢺ࣮ࣜ࢞࡜㐃ືࡉࡏ࡚ࠊ㉸㧗㏿ᗘ⌧㇟ࡢ᧜ᙳࡶ࡛ࡁࡿࠋ

FLIR SC7500TEC ࡣ 1.5 µm ~ 5. 1 µm ࡢ୰㉥እᇦࢆ᳨ฟࡍࡿ InSb ⣲Ꮚࢆᦚ㍕ࡋࡓ㉸㏿ᗘ㉥እ⥺࣓࢝ࣛࠋ3.5 µm ~ 5.0 µm ࢆ㏱㐣ࡍࡿ㉥እ⥺ࣞࣥࢬࢆᶆ‽⿦ഛࠋ320 × 256 ࡢゎീᗘ࡛ 380 ࢥ࣐/⛊ࡢ᧜ᙳࡀྍ⬟ࠋ᭱኱
᧜ീ㏿ᗘࡣ 20000 ࢥ࣐/⛊㸦64 × 4 ࣆࢡࢭࣝ㸧ࠋእ㒊ࢺ࣮ࣜ࢞࡜㐃ືࡉࡏ࡚ࠊ㧗㏿ᗘ⌧㇟ࢆ୰㉥እἼ㛗࡛ᤊ࠼ࡿࡇ࡜ࡀ࡛ࡁࡿࠋࡩࡃᑕ⋡ࡀ᪤▱࡛࠶ࢀࡤࠊ≀య⾲㠃ࡢ

ᗘศᕸࡢィ

ࡀྍ⬟ࠋ

ࢧ࣮࣐ࣝࣅࢪࣙࣥ LAIRD 3ASH ࡣ 1280×1024 ࡢゎീᗘ࡛ 2916 ࢥ࣐/⛊ࡢ᧜ᙳࡀྍ⬟ࠋ1024 × 768 ࡢゎീᗘ࡛ 4628 ࢥ࣐/⛊ࠊ᭱኱࡛ 60 ୓ࢥ࣐/⛊ࡲ࡛᧜ᙳྍ⬟㸦16 × 4 ࣆࢡࢭࣝ㸧ࠋࣔࣀࢡ࡛ࣟឤᗘࡣ ISO20000ࠋࣇࣝࣇ࣮࣒࡛ࣞࡢ᭱኱᧜ീࢥ࣐ᩘࡣ⣙ 5000 ᯛ࡛࠶ࡿࠋࢺ࣮࣮ࣜ࢞ࣔࢻࢆ㐺ษ࡟タᐃࡍࢀࡤࠊࣅࢹ࣓࢜࢝ࣛឤぬ࡛⡆༢࡟㧗㏿⌧㇟ࢆᤊ࠼ࡿࡇ࡜ࡀ࡛ࡁ
ࡿࠋPC ࡞ࡋ࡛ࡢࣜࣔࢥࣥ᧯సࡶྍ⬟࡛ࠊእ㒊ࢺ࣮ࣜ࢞࡜㐃ືࡉࡏ࡚ࠊ
㉸㧗㏿ᗘ⌧㇟ࡢ᧜ᙳࡶ࡛ࡁࡿࠋ
ࣃࣝࢫࢪ࢙ࢿ࣮ࣞࢱ DG-535 ࡣ 4 ࢳࣕࣥࢿࣝ㐜ᘏฟຊࠊ2 ⣔⤫ࣃࣝࢫฟຊࢆഛ࠼ࡓ㐜ᘏࣃࣝࢫⓎ⏕ჾ࡛࠶ࡿࠋ᫬㛫ศゎ⬟ 5 psࠊࢺ࣮ࣜ࢞ฟຊࡢ
ࢪࢵࢱ࣮ࡣ 50 ps ௨ୗࠋ」ᩘࡢ

ᐃᶵჾ࠾ࡼࡧᐇ㦂⿦⨨ࡢྠᮇࢆᚲせ࡜ࡍࡿ㝿࡟᭷⏝࡛࠶ࡿࠋ

11. ศගගᗘィ㸦⣸እྍど࣭㉥እ㸧࣭᪕ගィ࠙ᶵჾศᯒᐊ 3ࠚპ㸧⣸እྍどศගගᗘィ㸦UV-Vis㸧≀㉁࡟ࡼࡿ⣸እཬࡧྍど㡿ᇦ㸦⣙ 200 ~ 700 nm㸧ࡢගࡢ྾཰ࡣࡑࡢศᏊෆࡢ㟁Ꮚᵓ㐀࡟౫Ꮡࡋ࡚࠾
ࡾࠊ㟁Ꮚࡀᇶᗏ≧ែ࡟࠾ࡅࡿ㌶㐨࠿ࡽ㧗࠸࢚ࢿࣝࢠ࣮ࡢ㌶㐨࡬㑄⛣ࡍࡿࡇ࡜࡟ࡼࡾ࠾ࡇࡿࠋ౛࡜ࡋ
࡚ࠊ㑄⛣㔠ᒓ໬ྜ≀࡟࠾ࡅࡿ d-d 㑄⛣ࡸ஧㔜⤖ྜࢆ᭷ࡍࡿ᭷ᶵ໬ྜ≀ࡢ S-S* ࡀ࠶ࡆࡽࢀࡿࠋࡑࡢࡓ
ࡵࠊ⣸እྍど྾཰ࢫ࣌ࢡࢺࣝ࠿ࡽࡑࡢࡼ࠺࡞໬ྜ≀ࡢྠᐃࡸᐃ㔞ࡀࠊࡉࡽ࡟ࡣᮍ▱໬ྜ≀ࡢ㟁Ꮚ≧ែࡢ᳨ウࡀྍ⬟࡛࠶ࡿࠋLambda950 ࡣගᏛ⣔඲యࢆ❅⣲ࣃ࣮ࢪࡍࡿࡇ࡜࡟ࡼࡾࠊ⣸እഃࡣ 175 nmࡢἼ㛗⠊ᅖࡲ࡛

ᐃ࡛ࡁࡿࠋ࢚ࢿࣝࢠ࣮ࢆ᭱㐺໬ࡋࡓගᏛ⣔ࡣࠊ⣸እྍ

ど㏆㉥እࡢ඲㡿ᇦ࡛ࠊඃࢀࡓ SN ẚ㸦500 nm ࡛ 0.00005 Abs ௨ୗ㸧ࢆ᭷ࡍ
ࡿࠋUV WinLab ࢯࣇࢺ࢙࢘࢔࡟ࡼࡾࠊࢫ࢟ࣕࣥࠊ᫬㛫ࠊከἼ㛗ࠊ⃰ᗘᐃࡀ⡆༢࡟᧯స࡛ࡁࠊ㏻ᖖࡢ྾཰ࢫ࣌ࢡࢺࣝ࡟ຍ࠼ࠊᣑᩓ཯ᑕࡸṇ཯ᑕࡢࢫ࣌ࢡࢺࣝࡢ

ᐃࡶ࡛ࡁࡿࠋ

ჟ㸧ࣇ࣮࢚ࣜኚ᥮ᆺ㉥እศගගᗘィ㸦FT-IR㸧㉥እศගἲ㸦Infrared spectroscopy, IR㸧࡛ࡣࠊ≀㉁࡟ࡼࡿ㉥እ⥺㸦⣙ 5,000㹼300 cm-1㸧ࡢ྾཰ࡣࡑ
ࡢศᏊࡢ᣺ືᵓ㐀࡟౫Ꮡࡋ࡚࠾ࡾࠊ㸯ಶࡢ᣺ື࢚ࢿࣝࢠ࣮ࡢኚ໬࡟కࡗ࡚ከᩘࡢᅇ㌿࢚ࢿࣝࢠ࣮ኚ
໬ࡀ㉳ࡇࡿࡢ࡛ࠊ᣺ືࢫ࣌ࢡࢺࣝࡣ᣺ື྾཰ᖏ࡜ࡋ࡚⌧ࢀࡿࠋ྾཰ࡢ᣺ືᩘ࠶ࡿ࠸ࡣἼ㛗ࡣࠊ᣺ື㒊ศࡢ᥮⟬㉁㔞ࠊ໬Ꮫ⤖ྜࡢຊࡢᐃᩘ࠾ࡼࡧཎᏊࡢᗄఱᏛⓗ㓄⨨࡟౫Ꮡࡍࡿࡢ࡛ࠊ㉥እࢫ࣌ࢡࢺࣝ
࠿ࡽศᏊᵓ㐀ࢆゎᯒࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋࣇ࣮࢚ࣜኚ᥮ᆺ IR㸦FT-IR㸧࡛ࡣࠊ㉥እගࢆࣅ࣮࣒ࢫࣉࣜ
ࢵࢱ࡟ࡼࡾ 2 ࡘࡢග㊰࡟ศࡅࠊᅛᐃ㙾࡜⛣ື㙾࡛཯ᑕࡉࢀࡓගࡢග㊰ᕪ࡟ࡼࡾᖸ΅Ἴࡀ࡛ࡁࡿࠋヨᩱࢆ㏱㐣ࡋࡓᖸ΅Ἴ࠿ࡽࠊ᳨ฟჾ࡛ࣇ࣮࢚ࣜኚ᥮࡟ࡼࡾἼᩘᡂศ࡟ศ㞳ࡉࢀࡓ IR ࢫ࣌ࢡࢺࣝࡀᚓ
ࡽࢀࡿࠋSpectrum100 ࡣ࣐࢖ࢣࣝࢯࣥᆺᖸ΅ィࢆഛ࠼ࡓ㧗ศゎ⬟ࠊ㧗Ἴᩘ⢭ᗘࠊ㧗ឤᗘࡢࣇ࣮࢚ࣜኚ᥮ᆺ㉥እศගගᗘィ࡛࠶ࡿࠋࢫ࣌ࢡࢺࣝࡢ✚⟬ࡸ㧗㏿ᐃᐃࡀྍ⬟࡛ࠊࢫ࣌ࢡࢺࣝࡢᩘᏛⓗ࡞ฎ⌮㸦ຍῶ஌㝖㸪ᚤศ✚ศ࡞࡝㸧ࡀᐜ᫆࡟⾜࠼ࡿࠋࡲࡓࠊHATR㸦Ỉᖹᆺෆ㒊ከ㔜཯ᑕࡢ౑⏝࡟ࡼࡾࠊᚑ᮶ࡢ㉥እศගගᗘィ࡛ࡣᐃ⿦⨨㸧ᐃࡀ㞴ࡋ࠸࡜ࡉࢀࡓỈ⁐ᾮࠊ࣮࣌ࢫࢺ➼࡟ࡘ࠸࡚ࡶࢫ࣌ࢡࢺࣝࢆᚓࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

㢧ᚤ IR 460Plus ࡣࠊᚤᑠࠊᚤ㔞ࢧࣥࣉࣝࡔࡅ࡛࡞ࡃࠊᚑ᮶ࠊ࣐ࢡࣟศᯒ
ࡉࢀ࡚࠸ࡓヨᩱࡶ㢧ᚤ㙾ࢆ౑⏝ࡋ࡚ᐜ᫆࡟ィ࡛ࡁࠊᛂ⏝⠊ᅖࡀᗈ࠸ࠋ

౛࠼ࡤࠊᩘ༑ µm ⛬ᗘࡢᚤᑠ࣭ᚤ㔞ࢧࣥࣉࣝࠊ࠶ࡿ࠸ࡣ୙ᆒ୍ヨᩱ୰ࡢ≉ᐃ㒊఩ࡢ㠀◚ቯᐃࡀྍ⬟࡛࠶ࡾࠊ᪂⣲ᮦࠊ᪂ࡋ࠸ᚤ⣽ࢹࣂ࢖ࢫࡢ⾲㠃ศᯒ࡟ጾຊࢆⓎ᥹࡛ࡁࡿࠋࡉࡽ࡟ࠊᮏࢩࢫࢸ࣒ࡣ㟁ሙ ATR㸦඲཯ᑕ㸧ࣘࢽࢵࢺࢆഛ࠼࡚࠾ࡾࠊᚤᑠ཯ᛂሙ࡟࠾ࡅࡿࣜ࢔ࣝࢱ࢖࣒࡛ࡢィ

ࡀྍ

⬟࡛࠶ࡿࠋ
ReactIR 4000 ࡣᲬ≧ࡢࣉ࣮ࣟࣈ㸦6 mm㸧ࢆ⁐ᾮ୰࡟┤᥋ᕪ㎸ࢇ࡛㉥እ྾཰ࢫ࣌ࢡࢺࣝࢆ

ᐃࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋ㐃⥆ⓗ࡞ᐃ࡟ࡼࡾᐇ㝿

ࡢ཯ᛂ᮲௳࡟࠾ࡅࡿศᏊࡢࣜ࢔ࣝࢱ࢖࣒࡞ືⓗ໬Ꮫኚ໬ࢆᐃ㔞ⓗ࡟ྍど໬࡛ࡁࡿࠋ౛࠼ࡤࠊ໬Ꮫ཯ᛂ୰࡟ࡢࡳᏑᅾࡍࡿᚤ㔞ࡢ཯ᛂ୰㛫యࡢྠᐃࡀྍ⬟࡛ࠊཎᩱࡢᾘኻ㏿ᗘࠊ⏕ᡂ≀ࡢ⏕ᡂ㏿ᗘࢆࣆ࣮ࢡᙉᗘࡢኚ໬࠿ࡽ
ᐃ㔞ⓗ࡟ほᐹࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡓࡵࠊ໬Ꮫ཯ᛂᶵᵓࠊḟᩘࡢゎᯒ࡟ከ࠸
࡟ᙺ❧ࡘࠋ



RT/IR-4700 ࡣ SN ẚࡢ㧗࠸ࠊࢥࣥࣃࢡࢺ࡞ࣇ࣮࢚ࣜኚ᥮ᆺศගගᗘィ࡛ࠊ࣮ࣝࢸ࢕ࣥࡢศᯒ࡟㐺ࡋ࡚࠸ࡿࠋ࣐ࣝࢳࢳࣕࣥࢿࣝ㉥እ㢧ᚤ㙾࡟ᑐᛂࡋ࡚࠾ࡾࠊࣛࣆࢵࢻࢫ࢟ࣕࣥ
7800㹼350 cm

í1ᐃࡀྍ⬟࡛࠶ࡿࠋ

ᐃἼᩘ⠊ᅖࡣ

࡛ࠊ SN ẚࡣ 25000:1 ࡛࠶ࡿࠋࣅ࣮࣒ࢫࣉࣜࢵࢱ࡟ࡣ

.%U ࡟⵨╔ࡉࢀࡓ Ge ࡀ⏝࠸ࡽࢀ࡚࠸ࡿࠋ㧗㍤ᗘࢭ࣑ࣛࢵࢡࢆග※࡜ࡋࠊ࣮࢜ࢺ࢔ࣛ࢖࣓ࣥࢺᶵᵓࢆ᭷ࡍࡿᐦ㛢ᆺࡢ 45º ධᑕ࣐࢖ࢣࣝࢯࣥᖸ΅ィࡀഛ࠼ࡽࢀ࡚࠸ࡿࠋ

III㸧᪕ගィ㸦Polarimeter㸧᪕ග㸦optical rotation㸧࡜ࡣࠊ┤⥺೫ගࡀ⢾࡞࡝ࡢගᏛάᛶࢆ᭷ࡍࡿ≀㉁୰ࢆ㏻㐣ࡋࡓ㝿࡟ᅇ㌿ࡍࡿ⌧㇟࡛࠶ࡿࠋ୍⯡ⓗ࡟ࠊ᭷ᶵศᏊ࡜ࡑࡢᑐᤸయࡣගᏛ␗ᛶయᑐࢆ࡞ࡋࠊ୍᪉ࡢ❧య㓄⨨ࡀ㹐㓄⨨࡞ࡽࡤࠊࡶ࠺୍᪉ࡢ㓄⨨ࡣ㹑㓄⨨࡜࿧ࡤࢀࡿࠋࢹ࢟ࢫࢺ࣮ࣟࢫ㸦dextrose㸸ྑ᪕⢾ࠊࣈࢻ࢘⢾㸧ࡢྡ⛠ࡣ┤⥺೫ගࢆྑ㸦dexter㸧ഃ࡟ࠊࣞࣈ࣮ࣟࢫ㸦levulose㸸ᕥ᪕⢾ࠊࣇࣝࢡࢺ࣮ࢫ㸧ࡣᕥ㸦levo㸧ഃ࡟ᅇ㌿ࡉࡏࡿ⌧㇟࠿ࡽ࿨ྡࡉࢀࡓࠋ⣧≀㉁ࡢ⁐ᾮࡢሙྜࠊⰍ࡜⤒㊰㛗ࡀ୍ᐃ࡛ẚ᪕ගᗘࡀศ࠿ࢀࡤࠊほ ࡉࢀࡓ᪕ගᗘ࠿ࡽ⃰ᗘࢆồࡵࡿࡇ࡜ࡀ࡛ࡁࡿࠋ౛࠼ࡤࠊ୙ᩧྜᡂ࡟ࡼࡾᚓࡽࢀࡓ⏕ᡂ≀ࡢගᏛ⣧ᗘࢆỴᐃࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
P-2300 ࡣࠊࢼࢺ࣒ࣜ࢘-Ỉ㖟ࣛࣥࣉࡢࢹࣗ࢔ࣝග※࡜ࠊ஧ࡘࡢ」ᒅᢡ
ࣉࣜࢬ࣒࡛ᵓᡂࡉࢀࡓഃ㠃࡟࢚ࢫࢣ࣮ࣉ❆ࡢ↓࠸ࢢࣛࣥࢸ࢖࣮ࣛ೫
ගᏊࢆ᭷ࡍࡿ᪕ගィ࡛ࠊ㍤⥺ࢆ⏝࠸ࡓ㧗⢭ᗘ࡞ ᐃࡀྍ⬟࡛࠶ࡿࠋ
ග※࡜ࡋ࡚ࡣỗ⏝ⓗ࡟ࣁࣟࢤࣥࣛࣥࣉࡀ౑⏝࡛ࡁࠊග※࡜ࡋ࡚ྠ᫬
࡟ 2 ✀㢮ࡲ࡛ᮏయ࡟ᦚ㍕࡛ࡁࡿࠋ ᐃἼ㛗ࡣ 589, 578, 546, 436, 365m㸦࢜ࣉࢩࣙࣥἼ㛗ᑐᛂ㸧࡛ࠊ ᐃ᪉ᘧ࡜ࡋ࡚ࠊᑐ⛠ゅ᣺ື᪉ᘧග
Ꮫ㞽఩ἲࢆ⏝࠸࡚࠸ࡿࠋ

12. ෇஧Ⰽᛶศᩓィ㸦CD spectrometer㸧࠙ᶵჾศᯒᐊ 3ࠚ᭷ᶵศᏊࡀᑐᤸయ࡜㔜ࡡྜࢃࡍࡇ࡜ࡀ࡛ࡁ࡞࠸❧య㓄⨨ࢆࡶࡘ࡜ࡁࠊࡑࡢᛶ㉁ࢆ࢟ࣛࣜࢸ࢕࣮࡜
࠸࠸ࠊᕥᅇࡾ෇೫ග࡜ྑᅇࡾ෇೫ගࢆ␗࡞ࡗࡓᙉᗘ࡛྾཰ࡍࡿࠋࡇࡢᛶ㉁ࢆ෇೫ග஧Ⰽᛶ㸦Circular
Dichroism, CD㸧࡜࠸࠺ࠋ୍⯡ⓗ࡟ࠊ᭷ᶵศᏊ࡜ࡑࡢᑐᤸయࡣගᏛ␗ᛶయᑐࢆ࡞ࡋࠊ୍᪉ࡢ❧య㓄⨨ࡀ㹐㓄⨨࡞ࡽࡤࠊࡶ࠺୍᪉ࡢ㓄⨨ࡣ㹑㓄⨨࡜࿧ࡤࢀࡿࠋ⏕య࡛ࡣගᏛ␗ᛶయᑐࡢ୍᪉ࡢࡳࡀᏑᅾࡋ
࡚࠾ࡾࠊᵓᡂࡉࢀࡿ㧗ศᏊࡀ❧యⓗ࡟࠺ࡲࡃᢡࡾ␚ࡲࢀࡓ≧ែ㸦㧗ḟᵓ㐀㸧࡛ࠊࡑࡢ⊂⮬ࡢᶵ⬟ࡣⓎ⌧ࡍࡿࡼ࠺࡟࡞ࡿࠋᕥᅇࡾ෇೫ග࡜ྑᅇࡾ෇೫ග࡟ᑐࡍࡿ྾ගᗘࡢᕪࢆἼ㛗࡟ᑐࡋ࡚ࣉࣟࢵࢺࡋ
ࡓࡶࡢࡀ CD ࢫ࣌ࢡࢺ࡛ࣝ࠶ࡿࡀࠊࡇࢀࡣࡑࡢศᏊࡢ⤯ᑐ㓄⨨࡟ᅛ᭷ࡢࣃࢱ࣮ࣥࢆ♧ࡍࠋJ-820P ࡣගᏛάᛶ࡞≀㉁ࡢ෇೫ගࢆ

ᐃࡍࡿ⿦⨨࡛࠶ࡾࠊࢱࣥࣃࢡ㉁ࡢ

2 ḟᵓ㐀ྵ㔞࡞࡝ࠊගᏛάᛶ࡞≀㉁ࢆྵࡴ⏕య㧗ศᏊࡢᵓ㐀ゎᯒ࡟⏝࠸ࡽࢀࡿࠋ⏕యศᏊࡢ㧗ḟᵓ㐀ࡢゎᯒ࡛ࡣࠊᑐᤸయࡢ࠺ࡕࡢ࠸ࡎࢀࡀᏑᅾ
ࡍࡿ࠿ࢆỴᐃࡍࡿࡇ࡜ࡣ㔜せ࡛࠶ࡿࠋCD ࢫ࣌ࢡࢺࣝࡣ⏕య㧗ศᏊࡢ⤯ᑐ㓄⨨࡟ᅛ᭷ࡢࣃࢱ࣮ࣥࢆ♧ࡍࡢ࡛ࠊᚓࡽࢀࡓ CD ࢫ࣌ࢡࢺࣝࢆ㧗ḟᵓ㐀ࡀ᪤▱ࡢࢫ࣌ࢡࢺࣝ࡜ẚ㍑᳨ウࡍࡿࡇ࡜࡟ࡼࡾࠊ⏕య࠿ࡽᚓࡽࢀࡓᮍ
▱≀㉁ࡢ⤯ᑐ㓄⨨ࡢỴᐃࡀྍ⬟࡜࡞ࡿࠋ

13. ࣇ࢛ࢺ࣑ࣝࢿࢵࢭࣥࢫศᯒࢩࢫࢸ࣒࠙ᶵჾศᯒᐊ 3ࠚࣇ࢛ࢺ࣑ࣝࢿࢵࢭࣥࢫ㸦Photoluminescence, PL㸧ศᯒ࡛ࡣࠊ≀㉁࡟㟁☢Ἴࢆ↷ᑕࡋࠊບ㉳ࡉࢀࡓ㟁Ꮚࡀᇶᗏ≧ែ࡟ᡠࡿ㝿࡟ᨺฟࡍࡿ⺯ග㸦fluorescence㸧ࡸࡾࢇග㸦phosphorescence㸧ࢆ ᐃࡋ࡚ࠊⓎගࢫ࣌ࢡࢺࣝࢆゎᯒࡍࡿࠋⓎගࢫ࣌ࢡࢺࣝࡣ≀㉁୰ࡢ୙⣧≀ࡸ⤖ᬗ୰ࡢḞ㝗࡟ࡼࡾᙳ㡪ࢆཷࡅࡿࡢ
࡛ࠊࡇࢀࡽࡢ᝟ሗࡀᚓࡽࢀࡿࠋ౛࠼ࡤࠊ༙ᑟయᮦᩱ࡟࠾ࡅࡿ୙⣧≀✀ࡸ⤖ᬗᛶࠊΰᬗ⤌ᡂẚ࡞࡝ࡢศᯒ࡟⏝࠸ࡽࢀࡿࠋᶵ✀࡟ࡼࡾࠊ⺯ගᮦᩱࡸⓎගࢹࣂ࢖ࢫࡢホ౯ࡀ࡛ࡁࡿ
Quantaurus-Tau ࡣࠊࢧࣈࢼࣀ⛊ ~ ࣑ࣜ⛊ࡢ⺯ගᑑ࿨ࢆᐃࡍࡿ⿦⨨࡛

࠶ࡿࠋ⡆༢࡞᧯స࡟࡚㧗⢭ᗘ࡞⺯ගᑑ࿨࣭PL ࢫ࣌ࢡࢺࣝࢆ▷᫬㛫࡛ィ࡛ࡁࡿࠋ⺯ගᑑ࿨ࡢᛂ⏝౛ࡣከᒱ࡟Ώࡾࠊ᭷ᶵ㔠ᒓ㘒యࡢศᏊෆ࣭ศ
Ꮚ㛫㟁Ꮚ⛣ືࡸ࢚ࢿࣝࢠ࣮⛣ື཯ᛂࠊ᭷ᶵ EL ⣲Ꮚ㛤Ⓨ࡟ᚲせ࡞ᮦᩱࡢ⺯ගࡸࡾࢇගᑑ࿨ィࠊ⺯ග⺮ⓑ㉁ࡢ FRET㸦࢚ࢿࣝࢠ࣮⛣ື㸧ࠊLED⏝ࡢ໬ྜ≀༙ᑟయࡢⰋྰุᐃ࡞࡝ࡀ࠶ࡿࠋྠࡌἼ㛗࡛ࡶ⺯ගᑑ࿨ࡢ␗࡞
ࡿ≀㉁ࡀ」ᩘᏑᅾࡍࡿሙྜࠊᏑᅾẚ⋡ࡼࡾከࡃࡢ᝟ሗࡀᚓࡽࢀࡿࠋ
Quantaurus-QY ࡣࠊࣇ࢛ࢺ࣑ࣝࢿࢵࢭࣥࢫἲ࡟ࡼࡾࠊⓎග㔞Ꮚ཰⋡ࡢ⤯ᑐ್ࢆ▐᫬࡟

ᐃࡍࡿ⿦⨨࡛࠶ࡿࠋィࢯࣇࢺ࢙࢘࢔࡟ᩘ㡯┠ࢆᣦ♧ࡍࡿࡔࡅ࡛ࠊⓎග㔞Ꮚ཰⋡ࡸບ㉳Ἴ㛗౫ᏑᛶࠊPL ບ㉳ࢫ࣌ࢡࢺࣝ࡞࡝ࢆ
▷᫬㛫࡛ィ࡛ࡁࡿࠋ1 ศ࡯࡝࡛ゎᯒ⤖ᯝࢆᑟࡁฟࡍࡇ࡜ࡶྍ⬟࡛ࠊ㛤

Ⓨ࠿ࡽᛂ⏝◊✲ࡲ࡛ࡢᵝࠎ࡞ศ㔝࡛⏝࠸ࡽࢀ࡚࠸ࡿࠋ⁐ᾮࠊ⢊ᮎࠊᅛయࠊⷧ⭷࡟ᑐᛂࡋࠊ⁐ᾮヨᩱࢆᾮయ❅⣲ᗘ࡟෭༷ࡍࡿࡇ࡜ࡶ࡛ࡁࡿࠋ

PF-8600 ࡣගࢆヨᩱ࡟↷ᑕࡋ࢚ࢿࣝࢠ࣮ࢆ྾཰ࡋࠊⓎගࡍࡿࣇ࢛ࢺ࣑ࣝ
ࢿࢵࢭࣥࢫ㸦⺯ග࣭⇥ග㸧ࢆᐃࡍࡿ⺯ගศගගᗘィ࡛࠶ࡿࠋࡲࡓࠊ᳨

ฟឤᗘࢆ⮬ືⓗ࡟ㄪᩚࡍࡿ࣮࢜ࢺࢤ࢖ࣥࠊ࣮࢜ࢺ SCS ᶵ⬟ࠊ⮬ື㧗ḟග࢝ࢵࢺࣇ࢕ࣝࢱ࣮ࢆ⿦ഛࡋࠊᚑ᮶ࡢ⇥ගᑑ࿨࡟ຍ࠼ࠊ⇥ග࡟ࡼࡿᅛᐃἼ㛗ᐃࠊ ᐃ㔞ᐃ࡜⇥ගࢫ࣌ࢡࢺࣝ

ᐃࠊ᫬㛫ኚ໬ᐃᐃࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࠋ⁐ᾮࠊ⢊ᮎࠊᅛయࠊⷧ⭷࡟ᑐᛂࡀྍ⬟࡛ࠊ⁐ᾮヨᩱࢆᾮయ❅⣲ᗘ࡟෭༷ࡍࡿࡇ࡜ࡶ࡛ࡁࡿࠋ

14. ࢸࣛ࣊ࣝࢶ࢖࣓࣮ࢪࣥࢢࢩࢫࢸ࣒࠙ᶵჾศᯒᐊ 8ࠚࢸࣛ࣊ࣝࢶ㸦THz㸧㡿ᇦ࡟ࡣࠊ㍍࠸ศᏊࡢᅇ㌿㐠ືࡸศᏊ᣺ືࡢప࿘ἼᩘᡂศࠊỈ⣲⤖ྜࡢࡼ࠺࡞
ศᏊ㛫᣺ືࠊศᏊෆࡢෆ㒊ᅇ㌿㐠ືࡢ࿘Ἴᩘ࡞࡝ࡀ࠶ࡿࠋ㏆ᖺࠊࣇ࢙࣒ࢺ⛊࣮ࣞࢨ࣮ࡢᬑཬ࡟࡜ࡶ࡞



࠸ࠊTHz ᫬㛫㡿ᇦศගἲࢆ⏝࠸ࡓゎᯒࡀᛴ㏿࡟ⓎᒎࡋࠊศᏊࡢᵓ㐀ࡸ㐠ື≧ែ࡟ࡘ࠸࡚ࡢከࡃࡢ᝟ሗ
ࡀᚓࡽࢀࡿࡼ࠺࡟࡞ࡗࡓࠋ
THz-TDS ࡛Ⓨ⏕᳨࣭ฟࡍࡿ㟁☢Ἴࡢ࿘Ἴᩘᖏᇦࡣ THz ࡛࠶ࡿࠋࢸࣛ࣊ࣝ
ࢶගࡣ㐲㉥እග࡜ࡶ࿧ࡤࢀࠊࡑࡢἼ㛗ࡣ㟁Ἴ࡜㉥እ⥺࡜ࡢ୰㛫࡟࠶ࡾࠊ཮᪉ࡢ≉ᚩࢆᣢࡕྜࢃࡏ࡚࠸ࡿࠋศගᏛⓗ࡟ࡣỈ⣲⤖ྜࡸࣇ࢓ࣥࢹࣝ࣡
࣮ࣝࢫຊ࡟ᨭ㓄ࡉࢀࡿᙅ࠸┦஫స⏝ࡢ᣺ື࣮ࣔࢻࡀྵࡲࢀࡿࠋගᏛ⣔ࡢ㓄⨨࡜ไᚚࢯࣇࢺ࢙࢘࢔࡟ࡼࡾࠊ✵㛫ศゎࡋ࡞࠸ 2 ḟඖ㉮ᰝ㸭3 ḟඖ㉮ᰝ࡜㏱㐣㸭཯ᑕࡢ㑅ᢥࡀ࡛ࡁࡿࠋ࣮ࣞࢨ࣮ࡢ࢔ࣛ࢖࣓ࣥࢺࣔࢪ࣮ࣗࣝࡀ
⏝ពࡉࢀ࡚࠾ࡾࠊ⢭ᐦ࡞ㄪᩚ㸦< 10 µm㸧ࡀ࡛ࡁࡿࠋ
BS-60YSAISIN ࡣࠊࢡࣛࢫ 3B ࡢࣇ࢙࣒ࢺ⛊ࣇ࢓࢖ࣂ࣮࣮ࣞࢨ࣮࡛࠶ࡾࠊ
Ἴ㛗 780 nmࠊ1,560 nm ࡢ 2 Ἴ㛗ྠ᫬ฟຊࡀ࡛ࡁࡿࠋࣃࣝࢫ≧࣮ࣞࢨ࣮ࡣࠊ
࡜ࡶ࡟ࠊࣃࣝࢫᖜ < 100 fsࠊᖹᆒฟຊ > 20 mWࠊ⧞ࡾ㏉ࡋ࿘Ἴᩘ 50 ± 2
MHz ࡛࠶ࡿࠋࣅ࣮࣒ࡣ⦪೫ග࡛ࠊࣅ࣮࣒ᚄࡣࡑࢀࡒࢀ 2.5 ± 0.5 mm 㸦780
nm㸧
ࠊ4.0 ± 1.0 mm㸦1,560 nm㸧࡛࠶ࡿࠋ෭༷Ỉ➼ࡣ୙せ࡛ࠊ࣮ࣞࢨ࣮࣊ࢵ
ࢻ࡜ไᚚ⿦⨨ࡢࡳ࡛ືసࡍࡿࠋྠᮇಙྕฟຊ➃Ꮚ㸦SMA㸧ࡼࡾࠊ࣮ࣞࢨ
࣮⧞ࡾ㏉ࡋ࿘Ἴᩘ࡟ྠᮇࡋࡓ㟁Ẽࣃࣝࢫಙྕࡀฟຊࡉࢀࡿࠋ

15. ࣮ࣞࢨ࣮࣐ࣛࣥศගࢩࢫࢸ࣒㸦LRS㸧࠙ᶵჾศᯒᐊ 3ࠚ࣮ࣞࢨ࣮࣐ࣛࣥศගἲ㸦Laser Raman Spectroscopy, LRS㸧ࡣ᭱ࡶỗ⏝ᛶࡢ࠶ࡿศගศᯒἲࡢ୍ࡘ࡜
ࡋ࡚฼⏝ࡉࢀ࡚࠸ࡿࠋࡇࡢศගἲ࡛ࡣࠊ↷ᑕࡉࢀࡓ࣮ࣞࢨ࣮ග࡜≀㉁࡜ࡢ┦஫స⏝࡟ࡼࡾᩓ஘ࡉࢀ
ࡿ࣐ࣛࣥගࢆ ᐃࡍࡿࡇ࡜࡟ࡼࡾࠊ໬ྜ≀ࡢศᏊ✀ࠊཎᏊᅋࡢ✀㢮ࠊ⤖ྜ⤖ᬗᵓ㐀ࠊศᏊࡢ㓄ྥ≉ᛶ࡞࡝ࡢ᝟ሗࡀᚓࡽࢀࡿࠋ࣐ࣛࣥศගἲࡣࠊ㉥እ࡞࡝௚ࡢศගἲ࡟ẚ࡭࡚ࢧࣥࣉࣜࣥࢢࡀᐜ࡛᫆ࠊ
ᅛయࠊᾮయࠊẼయ࡞࡝ࢆၥࢃࡎ࡟㠀◚ቯศᯒࡀྍ⬟࡛ࠊࡉࡽ࡟ࠊin-situ ศᯒࡀ࡛ࡁࡿ࡞࡝ࡢ≉㛗ࢆ᭷ࡍࡿࠋࡑࢀᨾࠊ༙ᑟయࠊࢼࣀᮦᩱࠊᶵ⬟ᛶ᭷ᶵ㧗ศᏊࡢᵓ㐀ゎᯒ࡟୙ྍḞ࡞ᡭẁ࡜࡞ࡗ࡚࠸ࡿࠋ᭱
㏆࡛ࡣࠊࢱࣥࣃࢡ㉁࡞࡝ࡢ⏕య㧗ศᏊࡢᶵ⬟Ⓨ⌧࣓࢝ࢽࢬ࣒࡟㛵ࡍࡿ◊✲࡟ጾຊࢆⓎ᥹ࡋ࡚࠸ࡿࠋ
NRS-1000 ࡢບ㉳࣮ࣞࢨ࣮Ἴ㛗ࡣ 532 nm ࡛ࠊᏳᐃⓗ࡟౑⏝࡛ࡁࡿࡼ࠺࡟
⿦⨨ࡣ✵෭ࡉࢀ࡚࠸ࡿࠋ࣮ࣞࢨ࣮ග࡟ᑐࡍࡿᏳ඲ᑐ⟇࡜ࡋ࡚ࠊࢡࣛࢫ I
㸦JIS つ᱁㸧┦ᙜ࡛࢖ࣥࢱ࣮ࣟࢵࢡࢩࢫࢸ࣒࡟ᑐᛂࡍࡿ㧗ឤᗘ෭༷ᆺ
CCD ᳨ฟჾࡀᦚ㍕ࡉࢀ࡚࠸ࡿࠋ532 nm ບ㉳࡛࣐ࣛࣥࢩࣇࢺ್ࡣ 100 ~
8,000 cm-1 ࡢ⠊ᅖ࡛ᐃྍ⬟࡛࠶ࡿࠋ┿✵ࠊ㧗ᅽ࡞࡝ࡢ᮲௳ࢆᚲせ࡜ࡏࡎࠊ࣑ࢡࣟศᯒ࠿ࡽ࣐ࢡࣟศᯒࡲ࡛ᑐᛂ࡛ࡁࠊඹ↔ⅬගᏛ⣔࡟ࡼࡾ᭱ᑠ
1 µm ࡲ࡛ࡢヨᩱࢆᐃࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

16. ⇕ศᯒࢩࢫࢸ࣒㸦EXSTAR-6000 Series㸧࠙ᶵჾศᯒᐊ 3ࠚ⇕ศᯒࡣࠊ ᗘኚ໬࡟࡜ࡶ࡞࠺≀㉁࣭ᮦᩱࡢᵓ㐀ኚ໬ࢆㄪ࡭ࡿ᪉ἲ࡛࠶ࡿࠋ໬ྜ≀ࡸᮦᩱࡢࡉࡲࡊ
ࡲ࡞⇕⌧㇟㸦⼥ゎࠊ࢞ࣛࢫ㌿⛣ࠊ⤖ᬗ໬ࠊ◳໬ࡸ㔜ྜ➼ࡢ཯ᛂࠊ᪼⳹࣭⵨Ⓨࠊ⇕ศゎ࣭⬺Ỉࠊ⇕⭾ᙇ࣭⇕཰⦰ࠊ⇕ᒚṔ࡞࡝㸧ࡢゎ᫂࡜࠸࠺ᇶ♏◊✲ࡸࠊ᪂つ㛤Ⓨᮦᩱࡢ⇕≉ᛶࡢホ౯ࠊ⏕⏘㒊㛛࡛ࡢရ㉁⟶⌮࡞࡝ࡢᛂ⏝◊✲ࡲ࡛ᖜᗈࡃ฼⏝ࡉࢀ࡚࠸ࡿࠋ ᐃᑐ㇟࡜ࡋ࡚ࡣࠊ᭷ᶵ≀࠿↓ᶵ≀࡛࠶ࡿ࠿ࢆၥࢃࡎࠊ
పศᏊ໬ྜ≀࠿ࡽ㧗ศᏊᮦᩱࡲ࡛ࠊ࠶ࡽࡺࡿศ㔝ࡢ໬ྜ≀࣭ᮦᩱࢆ࢝ࣂ࣮ࡋ࡚࠸ࡿࠋ
ᙜศ㔝࡟ࡣࠊ⇕ศᯒࢩࢫࢸ࣒ EXSTAR-6000 Series㸦࢚ࢫ࢔࢖࢔࢖࣭ࢼࣀࢸࢡࣀࣟࢪ࣮〇㸧࡜ࡋ࡚ࠊձ♧ᕪ㉮ᰝ⇕㔞ィ㸦differential scanning calorimetry, DSC㸧 ղ⇕㔜㔞࣭♧ᕪ⇕ྠ᫬ᐃ⿦⨨㸦thermo-

gravimetry/differential thermo-analysis, TG/DTA㸧 ճ⇕ᶵᲔศᯒ⿦⨨㸦thermomechanical analyzer, TMA㸧ࡀタ⨨ࡉࢀ࡚࠸ࡿࠋ

♧ᕪ㉮ᰝ⇕㔞ィ㸦DSC㸧ࡣࠊヨᩱࡢ≧ែኚ໬࡟ࡼࡿ྾⇕཯ᛂࡸⓎ⇕཯ᛂࢆᐃࡍࡿ⿦⨨࡛࠶ࡿࠋDSC6100㸦ᕥࠊᗘ⠊ᅖ㸸-150 ~ 500ºC㸧ࡣ⏕࿨⛉Ꮫ࡟࠾ࡅࡿࢱࣥࣃࢡ㉁⁐ᾮ࡞࡝ࡢ㧗ឤᗘᐃ⏝࡛࠶ࡿࠋ෭༷ࡣᾮయ

❅⣲⁀ࡵࢡ࣮ࣜࣥࢢ࢝ࣥࢆ౑⏝ࡍࡿࠋヨᩱࡢ྾⇕࣭Ⓨ⇕࡟క࠺⇕ὶࡢኚ໬ࢆ᳨▱ࡋࠊ⇕ᐜ㔞ࠊ཯ᛂᗘ࡞࡝ࡀᐃ࡛ࡁࡿࠋDSC6200㸦ྑࠊ⠊ᅖ㸸-150 ~ 725ºC㸧ࡣᅛయ௨እ࡟ᾮయࡶ
࡟୍ᐃࡢ⇕ࢆຍ࠼࡚୧⪅ࡢᗘᐃྍ⬟࡛ࠊヨᩱ࡜ᇶ‽≀㉁ᗘᕪࢆᤊ࠼ࠊヨᩱࡢ≧ែኚ໬ࡸ⤖ᬗ໬࡞࡝ࡀศᯒ࡛ࡁࡿࠋ
⇕㔜㔞࣭♧ᕪ⇕ྠ᫬ᐃ⿦⨨㸦TG/DSC㸧ࡣࠊヨᩱࡢຍ⇕࡟క࠺㔜㔞ኚ໬ࢆ᳨ฟࡋࠊᇶ‽≀㉁࡜ࡢ
ࡿࠋNEXTA STA300 ࡣᗘᕪࢆᗘ㛵ᩘ࡜ࡋ࡚

ᐃࡍࡿ⿦⨨࡛࠶

ᗘࢆࣉࣟࢢ࣒ࣛ࡟ᚑࡗ࡚ኚ໬ࡉࡏ࡞ࡀࡽࠊヨᩱࡢ㔜㔞ኚ໬࡜྾⇕࣭Ⓨ⇕ࢆᐃࡍࡿࡇ࡜ࡀ࡛ࡁࡿ⿦⨨࡛࠶ࡿࠋᏳᐃᛶ

࡟ඃࢀ࠿ࡘ㧗ឤᗘ࡞Ỉᖹᕪື᪉ᘧࢆ᥇⏝ࡋ࡚࠾ࡾࠊ

ᐃ⠊ᅖࡣᐊ

࠿ࡽ

ႏࡲ࡛ࠊTG ࣮࣋ࢫࣛ࢖ࣥᛶ⬟ࡣ 10 µg ௨ୗ࡛࠶ࡿࠋ⇕Ᏻᐃᛶࡸ⇕ศゎᣲືࢆホ౯ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
⇕ᶵᲔศᯒ⿦⨨㸦TMA㸧ࡣࠊࣉࣟࢢ࣒ࣛ࡟ᚑࡗ࡚ヨᩱࡢࡏࠊࡑࡢ㐣⛬࡛ࠊヨᩱ࡟୍ᐃⲴ㔜ࢆຍ࠼࡞ࡀࡽࠊ

ᗘࢆኚ໬ࡉᗘ࡟ᑐࡍࡿኚᙧࢆ

ᐃࡍࡿ⿦⨨࡛࠶ࡿࠋTMA/SS6100 ࡜ TMA/SS6300 ࡛ࡣࠊ⅔య࡜ࣉ࣮ࣟࣈ
ࡣ␗࡞ࡿࡀࠊඹ㏻ࡢ

ᐃࣘࢽࢵࢺࢆ౑⏝ࡍࡿࠋ

ᐃ⠊ᅖࡣᐊ

࠿ࡽ

ႏࡲ࡛ࠊ┠ⓗ࡟ࡼࡾࠊ⭾ᙇ࣭ᅽ⦰ࠊ㔪ධࠊᘬᙇࡾࣉ࣮ࣟࣈࢆ౑⏝ࡍࡿࠋᗘኚ໬࡟ᑐࡋ࡚ࠊヨᩱࡢ⇕⭾ᙇࡸ㌾໬➼ࡢኚᙧࡀ㉳ࡇࡿ࡜ࠊࡑࢀ

࡟క࠺ኚ఩㔞ࡀࣉ࣮ࣟࣈࡢ఩⨨ኚ໬㔞࡜ࡋ࡚ィࡉࢀࡿࠋ

17. ⢏Ꮚゎᯒࢩࢫࢸ࣒࠙ᶵჾศᯒᐊ 3ࠚᙜศ㔝࡟ࡣࠊ⢏Ꮚࡢᙧ≧ࡸ≉ᛶࢆゎᯒࡍࡿࡓࡵࡢ⿦⨨࡜ࡋ࡚ࠊ࣐ࣝࣂ࣮ࣥࡢࣇ࣮ࣟᘧ⢏Ꮚゎᯒ⿦⨨FPIA-3000 ࡜⢏Ꮚᚄ࣭ࢮ࣮ࢱ㟁఩࣭ศᏊ㔞 ᐃ⿦⨨ Zetasizer Nano ZS ࡀタ⨨ࡋ࡚࠶ࡿࠋ



FPIA-3000 ࡣ⢏Ꮚ⏬ീ࠿ࡽ⢏Ꮚᙧ≧ࡸᚄ࡟㛵ࡍࡿ᝟ሗࢆฟࡍ⿦⨨࡛࠶ࡿࠋ኱ࡁࡉ࡜ᙧࡢ᝟ሗࢆ஧ḟඖ࡛ゎᯒࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋࡲࡓࠊಶࠎࡢ
⢏Ꮚࡢ᝟ሗࢆィࡍࡿࡢࡳ࡞ࡽࡎࠊከ㔞ࡢ⢏Ꮚࢆ୍ᗘ࡟

ྍ⬟࡛ࠊ⤫ィⓗಙ㢗ᛶࢆ☜ಖ࡛ࡁࡿࠋ

ᐃࡍࡿࡇ࡜ࡀ

ᐃ⠊ᅖࡣ 0.5 µm ~ 160 µm ࡛ࠊࣞࣥࢬ஺᥮࡟ࡼࡾ 0.25 µm ~ 300 µm ࡢ⠊ᅖࡢ⢏Ꮚࢆᐃ࡛ࡁࠊᬯど㔝ࢥࣥࢹࣥࢧ࣮ࢆ౑⏝ࡍࡿࡇ࡜࡛㍯㒌ࡀ୙᫂☜࡞⏬ീ࡬ࡶᑐᛂ࡛ࡁࡿࠋ㸯ᅇࡢᐃ࡛ࠊ᭱኱⣙ 36 ୓ಶࡢ⢏Ꮚࢆ▷᫬㛫㸦⣙ 2 ศ㸧࡛ᐃࡋࠊ㐃⥆ᐃࡶྍ⬟࡛࠶ࡿࠋ
Zetasizer Nano ZS ࡣ࣮ࣞࢨ࣮ᩓ஘ගࢆ⏝࠸࡚⢏Ꮚᚄࢆᐃࡍࡿࠊ㠀᥋ゐᚋ᪉ᩓ஘㸦non-invasive backscatter, NIBS㸧ගᏛ⣔ࢆ฼⏝ࡋࡓ㧗ᛶ⬟࡞ 2ゅᗘ᳨ฟ⣔ࡢศᯒ⿦⨨࡛࠶ࡿࠋ1 ྎ࡛ࢼࣀࢧ࢖ࢬ⢏Ꮚࡢ⢏ᏊᚄࠊศᏊ
㔞ࠊᣑᩓಀᩘࠊࢮ࣮ࢱ㟁఩ࠊ⢓ᙎᛶ࡞࡝ࡀ

ᐃྍ⬟࡛࠶ࡿࠋ౛࠼ࡤࠊࢮ

࣮ࢱ㟁఩࡟ࡼࡾࠊࢥࣟ࢖ࢻ⢏Ꮚࡢศᩓ࣭จ㞟ᛶࡸ┦஫స⏝࡞࡝ࠊ⏺㠃ࡢᛶ㉁ࢆホ౯ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋྛ

ᐃࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡟ࡼࡾࠊ⢏Ꮚࡢᵓ㐀ࡸศᏊ࡛ࣞ࣋ࣝࡢಟ㣭࡟ࡘ࠸࡚ゎᯒࡍࡿࡇ࡜ࡶྍ⬟࡛࠶ࡿࠋ18. ⢓ᙎᛶ ᐃࢩࢫࢸ࣒࠙ᶵჾศᯒᐊ 3ࠚᙜศ㔝࡟ࡣࠊ⢓ᙎᛶࢆ ᐃࡍࡿࡓࡵࡢ࣓࣮ࣞ࢜ࢱ࣮㸦Rheometrics㸧AR-*.* ࡜ືⓗ⢓ᙎᛶ ᐃ⿦⨨㸦Dynamic viscoelasticity Measuring Apparatus, DMA㸧Q800 KG ࡀタ⨨ࡉࢀ࡚࠾ࡾࠊከ✀ከᵝ࡞⢓ᙎᛶᐃ࡟ᑐᛂ࡛ࡁࡿࠋ

࣓࣮ࣞ࢜ࢱ࣮ࡣᛂຊࢆไᚚࡋ࡚ࠊ୺࡟ᾮయࢧࣥࣉࣝࡢ⢓ᙎᛶ≉ᛶࢆᐃࡍࡿ⿦⨨࡛࠶ࡿࠋAR-G2 KG ࡣࠊ㉸పࢼࣀࢺࣝࢡࢥࣥࢺ࣮ࣟࣝࢆྍ⬟࡟ࡍࡿࠊ☢Ẽᾋୖ᪉ᘧ࣋࢔ࣜࣥࢢࢸࢡࣀࣟࢪ࣮ࢆୡ⏺࡛ึࡵ࡚᥇⏝ࡋࡓ࣓࣮ࣞ࢜ࢱ࣮࡛࠶ࡿࠋࢻࣛࢵࢢ࢝ࢵࣉ࣮ࣔࢱ࣮ࠊࢫ࣐࣮ࢺࢫ࣡ࢵࣉࢪ࣓࢜
ࢺࣜࠊ࢖࣮ࢧࢿࢵࢺࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ࡞࡝ࢆ᭷ࡍࡿࠋᖜᗈ࠸ࢺࣝࢡ⠊ᅖࠊඃࢀࡓṍศゎ⬟ࠊᗈ⠊ᅖ࡞࿘Ἴᩘ࡞࡝ࡢ≉ᚩࢆᣢࡕࠊᅛయࠊప⢓ᗘ⁐ᾮࠊ⁐⼥࣏࣐࣮ࣜࠊ཯ᛂ≀㉁࡞࡝࡟㐺⏝࡛ࡁࠊࡑࡢᛂ⏝⠊ᅖࡣᗈ࠸ࠋDMA Q800 KG ࡣ㠀᥋ゐᘧ࡛ࠊᛂຊࢆṇ☜࡟ࢥࣥࢺ࣮ࣟࣝࡍࡿࣜࢽ࢔ࢻ
ࣛ࢖ࣈࢸࢡࣀࣟࢪ࣮ࡸపᦶ᧿࡛࠶ࡿ࢚࢔࣋࢔ࣜࣥࢢ➼ࡢ᭱ඛ➃ᢏ⾡ࢆᦚ
㍕ࡋ࡚࠸ࡿࠋᮦᩱࡢᙎᛶ࡜⢓ᛶࡢ୧᪉ࡢᛶ㉁ࡣࠊ2 ࡘࡢṍࡣឤᗘ࡜ศゎ⬟ࡢ㧗࠸࢜ࣉࢸ࢕࢚࢝ࣝࣥࢥ࣮ࢲࢸࢡࣀࣟࢪ࣮ࢆ౑ࡗ࡚

ᐃࡍࡿࠋṇᘻἼ

㸦ධຊ࡜ฟຊ㸧㛫ࡢ఩┦ᕪ࡛ࠊṇᘻἼࡢṍ㸦ᛂຊ㸧࡜ṇᘻἼࡢᛂຊ㸦ṍ㸧ࢆㄢࡋ࡚ㄪ࡭ࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋᮏ⿦⨨ࡣ୍ẁ࡜㧗࠸ᛶ⬟ࢆ᭷ࡋࠊ≉࡟」ྜᮦᩱࡢࡼ࠺࡞ᅛ࠸ᮦᩱ࡟᭱㐺࡛࠶ࡿࠋ

19. ≀㉁ᚤ⣽ᵓ㐀ゎᯒࢩࢫࢸ࣒࠙ᶵჾศᯒᐊ 7ࠚᙜศ㔝࡟ࡣࠊ≀㉁ࡢᚤ⣽ᵓ㐀ࢆヲ⣽࡟ゎᯒࡍࡿ X ⥺࣐࢖ࢡࣟ CT ࢫ࢟ࣕࣥ࡜ X ⥺ᅇᢡ⿦⨨ࡀタ⨨ࡉࢀ࡚࠸ࡿࠋX ⥺࣐࢖ࢡࣟ CT ࢫ࢟ࣕࣥ 6.<6&$1-GU ࡣࠊᕤᴗᮦᩱ࣭㣗ရ࣭⏕యヨᩱ࣭᭷ᶵᮦᩱ࣭㍍㔠ᒓ➼ࡢࢧࣥࣉࣝࡢ୕ḟඖෆ㒊ᵓ㐀ࢆ㠀◚ቯ࣭㧗ศゎ⬟࡛ほᐹ࡛ࡁࡿࠋ୍᪉ࠊX ⥺ᅇᢡ⿦⨨ SmartLab ࡣヨᩱ࡟ᛂࡌ࡚࢔ࣉࣜࢣ࣮ࢩࣙࣥࢆኚ࠼ࠊⷧ⭷ホ౯ࠊᾮయศᩓࢼࣀ⢏Ꮚศᯒࠊ⤖ᬗ໬ᗘホ౯࡞࡝ࡀ࡛ࡁࡿࠋ
SKYSCAN 1172-GU ࡣヨᩱࡢ୕ḟඖෆ㒊ᵓ㐀ࢆ㠀◚ቯ࣭㧗ศゎ⬟࡟࡚ほᐹࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡾࠊ᧜ീࡢᣑ኱ࣉࣟࢭࢫ࡛ࡣࢧࣥࣉࣝࢫࢸ࣮ࢪ࡜
X ⥺࣓࢝ࣛࡀྠ᫬࡟⛣ືࡍࡿ᭱᪂ࡢタィ࢔࣮࢟ࢸࢡࢳࣕࡀ᥇⏝ࡉࢀࡓࢩࢫࢸ࣒࡛࠶ࡿࠋᚑ᮶ࡢ X ⥺ CT ࡜ẚ㍑ࡋ࡚ࠊᩘಸࡢ㏿ࡉ࡛ࢫ࢟ࣕࣥࢆᐇ
⾜࡛ࡁࠊ᭱㧗✵㛫ศゎ⬟ࡣ 1 µm ௨ୗ࡛࠶ࡿࠋࢹ࣮ࢱࡢ෌ᵓᡂࡣࠊᶆ‽⿦ഛࡢ NRecon ࢯࣇࢺ࢙࢘࢔࠿ࠊ㧗㏿෌ᵓᡂࢯࣇࢺ࢙࢘࢔ࡢ Instarecon࡟ࡼࡾ▷᫬㛫࡛⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࠋ
SmartLab ࡣⓎᩓࣅ࣮࣒࣭ᖹ⾜ࣅ࣮࣒࣭㞟ගࣅ࣮࣒ࡢษࡾ᭰࠼ࡀᐜ࡛᫆
࠶ࡾࠊ᥋ゐᆺࢥࢿࢡࢱ᪉ᘧ᥇⏝࡟ࡼࡾࠊᐃ┠ⓗ࡟ᛂࡌ࡚ࣘࢽࢵࢺࢆ஺

᥮ࡍࡿࡔࡅ࡛ࠊࢧࣥࣉࣝ᝟ሗ࡟ᇶ࡙ࡁගᏛ⣲Ꮚࡸィᐃ᮲௳ࡀタᐃࡉࢀࠊ

ࡲ࡛ࡢ୍㐃ࡢࣉࣟࢭࢫࡀࢲ࢖࢔ࣟࢢ࣎ࢵࢡࢫ࡟ࡼࡾᥦ♧ࡉࢀࡿࠋ౛

࠼ࡤࠊᑐᛂⷧ⭷ホ౯࢔ࣉࣜࢣ࣮ࢩ࡛ࣙࣥࡣࠊ⤌ᡂศᯒࠊ᪉఩࣭㓄ྥศᯒࠊ⤖ᬗᛶホ౯ࠊ᱁Ꮚ⦆࿴ホ౯ࠊ᱁Ꮚṍ࣭ṧ␃ᛂຊホ౯ࠊ⭷ཌศᯒࠊ⏺
㠃ࣛࣇࢿࢫศᯒࠊᐦᗘศᯒࠊ㠃ෆᆒ୍ᛶホ౯࡞࡝ࡀࠊ✀⢊ᮎ࢔ࣉࣜࢣ࣮
ࢩ࡛ࣙࣥࡣᐃᛶศᯒࠊᐃ㔞ศᯒࠊ⤖ᬗ໬ᗘホ౯ࠊ⤖ᬗᏊࢧ࢖ࢬ/᱁Ꮚṍホ౯ࠊ᱁Ꮚᐃᩘࡢ⢭ᐦ໬ࠊRietveld ゎᯒ࡞࡝ࡀ⾜࠼ࡿࠋ࠙་Ꮫᆅ༊ࠚ
m1. ☢Ẽඹ㬆ศග⿦⨨㸦NMR㸧እ㒊㟼☢ሙ࡟⨨࠿ࢀࡓཎᏊ᰾ࡀᅛ᭷ࡢ࿘Ἴᩘࡢ㟁☢Ἴ࡜┦஫స⏝ࡍࡿ⌧㇟㸦᰾☢Ẽඹ㬆㸧ࢆ⏝࠸≀㉁ࢆศᯒࡍࡿ⿦⨨ࠋ⁐ᾮ≧ែ࡛ ᐃࡀฟ᮶ࠊཎᏊࣞ࣋ࣝࡢศゎ⬟ࢆᣢࡘࠋ་Ꮫᆅ༊࡟ࡣ 2 ྎࡢ NMR
ࡀタ⨨ࡉࢀ࡚࠸ࡿࠋ
AVANCE III 800 ࡣ୺࡟ࢱࣥࣃࢡ㉁ࢆࡣࡌࡵ࡜ࡍࡿ⏕య㧗ศᏊࡢ❧యᵓ㐀ゎᯒ࣭㐠ືᛶࡢゎᯒࠊ┦஫స⏝㒊఩ࡢྠᐃ➼࡟౑⏝ྍ⬟࡛࠶ࡿࠋࢡࣛ
࢖࢜ࣉ࣮ࣟࣈ࡟ࡼࡿ

ᐃឤᗘࡢ㣕㌍ⓗ࡞ྥୖ࡟ࡼࡾࠊ

ᐃ࡟࠿࠿ࡿ᫬㛫ࢆ㣕㌍ⓗ࡟▷⦰ࡉࢀࠊ16 ಸࡢࢧࣥࣉࣝࢫ࣮ࣝࣉࢵࢺࢆᐇ⌧ࡋ࡚࠸ࡿࠋ☢
ሙᙉᗘࡣ 18.8 T㸦Ỉ⣲ࡢඹ㬆࿘Ἴᩘ 800 MHz㸧࡛ࠊ1Hࠊ13Cࠊ15Nࠊ2H ᰾ࢆ↷ᑕࡋࠊ1H ࡛㧗ឤᗘࡢᐃࢆ⾜࠺ከ㔜ඹ㬆ᐃࡀྍ⬟࡛࠶ࡿࠋ



AVANCE III 600 ࡣ୺࡟ࢱࣥࣃࢡ㉁ࢆࡣࡌࡵ࡜ࡍࡿ⏕య㧗ศᏊࡢ❧యᵓ㐀ゎᯒ࣭㐠ືᛶࡢゎᯒࠊ┦஫స⏝㒊఩ࡢྠᐃ➼࡟౑⏝ྍ⬟࡛࠶ࡿࠋࢡࣛ
࢖࢜ࣉ࣮ࣟࣈ࡟ࡼࡿ

ᐃឤᗘࡢ㣕㌍ⓗ࡟ྥୖࡋ࡚࠸ࡿࠋ☢ሙᙉᗘࡣ 14.0

T㸦Ỉ⣲ࡢඹ㬆࿘Ἴᩘ 600 MHz㸧࡛ࠊ1Hࠊ13Cࠊ15Nࠊ31Pࠊ2H ᰾ࢆ↷ᑕ
ࡋࠊ1H ࡛㧗ឤᗘࡢᐃࢆ⾜࠺ከ㔜ඹ㬆ᐃࡀྍ⬟࡛࠶ࡿࠋ

m2. X ⥺ᅇᢡ㸦XRD㸧
ཎᏊࡀつ๎ⓗ࡟୪ࡪ⤖ᬗ࡟ X ⥺ࢆධᑕࡉࡏࡿ࡜ࠊ
ᩓ஘ࡉࢀࡓ X ⥺ࡢග㊰ᕪࡀἼ㛗ࡢᩚᩘಸࡢ࡜ࡁࠊ
㟁☢Ἴࡢ఩┦ࡀ୍⮴ࡋ࡚᣺ᖜࡀ኱ࡁࡃ࡞ࡾࠊᙉ࠸ X ⥺ࡀ≉ᐃࡢ᪉ྥ࡛ほᐹ࡛ࡁࡿࠋࡇࢀࢆ X ⥺ᅇᢡ㸦;ဨUD\GLIIUDFWLRQ, XRD㸧࡜࠸࠺ࠋXRD ࡣ X ⥺ࡀ⤖ᬗ᱁Ꮚ࡛ᅇᢡࡍࡿ⌧㇟ࡢࡇ࡜࡛࠶ࡾࠊ≀㉁ࡣࡑࢀ
ࡒࢀ࡟≉᭷࡞つ๎ᛶࢆᣢࡘ⤖ᬗࢆࡘࡃࡿࡇ࡜࠿ࡽࠊX ⥺ᅇᢡ࡛ࡣ≀㉁ࡢ⤖ᬗᵓ㐀ࡸ໬ྜ≀ࡢ✀㢮ࢆศᯒࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
FR-E SuperBright ࡣ≀㉁ࡢ⤖ᬗᵓ㐀ࡸ໬ྜ≀ࡢ✀㢮ࢆศᯒࡍࡿ⿦⨨࡛࠶ࡾࠊᅇ㌿ᑐ㝜ᴟᘧ &X.D ⥺ග※㸦Ἴ㛗 Ⴒ㸧ࢆ᭷ࡋࠊ࢖࣓࣮ࢪࣥࢢ
ࣉ࣮ࣞࢺ࡟ࡼࡿࢹࢪࢱࣝࢹ࣮ࢱྲྀᚓࡀྍ⬟࡛࠶ࡿࠋ㧗㍤ᗘග※࡜㧗ឤᗘ᳨ฟჾࡢ⤌ࡳྜࢃࡏ࡟ࡼࡾࠊᐇ㦂ᐊෆᶵ࡛࠶ࡾ࡞ࡀࡽ ~ 0.5 mm ゅࢧ࢖ࢬࡢࢱࣥࣃࢡ㉁⤖ᬗ࡟ᑐࡋ࡚ Ⴒ ⛬ᗘ௨ୖࡢ㧗ศゎ⬟ࢫ࣏ࢵࢺࢆྲྀᚓ
࡛ࡁࡿࠋ෭༷❅⣲࢞ࢫᄇࡁ௜ࡅᶵᵓ࡟ࡼࡾࠊࢹ࣮ࢱྲྀᚓ୰ࡢヨᩱ෭༷ࡀྍ⬟࡛࠶ࡿࠋࢱࣥࣃࢡ㉁⤖ᬗ࡟᭱㐺໬ࡉࢀࡓࢹ࣮ࢱ༙⮬ືྲྀᚓࢯࣇࢺࢆ
ᦚ㍕ࡋ࡚࠸ࡿࠋ

m3. 㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦ESR㸧☢ሙࡢᙳ㡪ୗ࡟⨨࠿ࢀࡓヨᩱ୰ࡢ୙ᑐ㟁Ꮚࡣࠊ࠶ࡿ≉ᐃࡢ࢚ࢿࣝࢠ࣮ࢆᣢࡘ㸦࿘Ἴᩘࡢ㸧࣐࢖ࢡࣟἼࢆ྾཰ࡋࠊ㧗࠸࢚ࢿࣝࢠ࣮‽఩࡬࡜㑄⛣ࡍࡿࠋࡇࡢ⌧㇟ࢆ฼⏝ࡍࡿࡇ࡜࡛୙ᑐ㟁Ꮚࡢ᳨ฟࢆ⾜࠺ࡢࡀ㟁Ꮚࢫࣆࣥඹ㬆࡛࠶ࡿࠋESR ࡣ㑅ᢥⓗ࡟ࣇࣜ㸫ࣛࢪ࢝ࣝࢆ ᐃ࡛ࡁࡿ၏୍ࡢᡭẁ࡛࠶ࡿࠋ
EMXmicro ࡣヨᩱࡢᙧ≧㸦ᾮయࠊẼయࠊᅛయ㸧࡟ᙳ㡪ࡉࢀࡎࠊ㠀◚ቯⓗ࡟ࠊ㑄⛣㔠ᒓ࢖࢜ࣥࡶࡋࡃࡣ᭷ᶵ໬ྜ≀୰ࡢࣇ࣮ࣜࣛࢪ࢝ࣝࢆ᳨ฟࡍࡿ
ࡇ࡜ࡀ࡛ࡁࡿ

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3฼⏝ࡢᡭᘬࡁ

1. ᶵჾศᯒศ㔝฼⏝ࡢᡭ㡰฼⏝⪅Ⓩ㘓฼⏝ணᐃ⪅㸦฼⏝⪅㈨᱁࡟ࡘ࠸࡚ࡣ 2. ࡢู⾲ 1 ࢆࡈཧ↷ୗࡉ࠸ࠋ㸧࡟ᶵჾ฼⏝ㅮ⩦఍ཧຍ⏦ࡋ㎸ࡳ᭩ཬࡧᶵჾ฼⏝⏦ㄳ᭩㸦2. ࡢู⾲ 2㸧ࢆᥦฟࡋ࡚࠸ࡓࡔࡁࡲࡍࠋ
Ў฼⏝⪅ㅮ⩦఍
ᐃᶵჾࢆึࡵ࡚౑ࢃࢀࡿ᪉࡟ࡣ୺࡟ 4 ᭶࠿ࡽ 6 ᭶࡟࠿ࡅ࡚⾜࠺฼⏝⪅ㅮ⩦఍ࢆཷㅮࡋ࡚㡬ࡁࡲࡍࠋЎ฼⏝ࡢ⏦ࡋ㎸ࡳ᪥᫬ࢆᶵჾศᯒศ㔝⫋ဨ࡟┦ㄯࡢ࠺࠼ࠊ

ᐃᕼᮃ᪥ࢆỴᐃ࠸ࡓࡋࡲࡍࠋ
Ў⿦⨨ࡢ฼⏝ཎ๎࡜ࡋ࡚฼⏝⪅ࡀ⮬ࡽᐃᶵჾࢆ㐠㌿࣭᧯సࡋ࡚࠸ࡓࡔࡁࡲࡍࠋ᫬㛫እࡢ฼⏝㸦ኪ㛫࠾ࡼࡧᅵ᪥㸧ࢆᕼᮃࡍࡿேࡣ᫬㛫እ฼⏝ᒆࢆࡈᥦฟࡃࡔࡉ࠸ࠋЎ㐠㌿᪥ㄅ฼⏝⪅ࡀᐇ㝿ࡢ฼⏝᫬㛫ࠊ฼⏝≧ἣࢆᐃᶵჾ࡟ഛ࠼௜ࡅࡢグ㘓⡙࡟グධࡋ࡚ࡃࡔࡉ࠸ࠋ୓୍ࠊ ᐃᶵჾࢆ◚ᦆࡋࡓሙྜࠊ࠶ࡿ࠸ࡣࠊ␗ᖖࢆㄆࡵࡓሙྜࡣࡓࡔࡕ࡟ᶵჾศᯒศ㔝⫋ဨ࡟㐃⤡ࡋ࡚ࡃࡔࡉ࠸ࠋ

‫⏦ࡢࢀࡒࢀࡑ ۍ‬㎸ࡳ⏝⣬ࡣᶵჾศᯒศ㔝ࡢ࣮࣒࣮࣍࣌ࢪ࡟ᥖ㍕ࡋ࡚࠶ࡾࡲࡍࠋ‫ྛ ۍ‬ᶵჾࡢ౑⏝ࡢ㝿ࡣࠊ⿦⨨࡟ഛ࠼௜ࡅࡢ⡆࣐᫆ࢽࣗ࢔ࣝࢆࡈཧ↷ୗࡉ࠸ࠋ‫ྛ ۍ‬ᶵჾࡢ౑⏝ᚋࠊᶵჾࡢ≧ែ࡟ࡘ࠸࡚Ẽࡀ௜࠸ࡓࡇ࡜ࡀ࠶ࡾࡲࡋࡓࡽࠊᶵჾࣀ࣮ࢺ࡟グ㍕ࡋ࡚ࡃࡔࡉ࠸ࠋ‫ ۍ‬ၥ࠸ྜࢃࡏ
ᶵჾศᯒศ㔝ࡢ฼⏝ᡭ㡰࡟㛵ࡍࡿ㉁ၥ

ĺ ᶵჾศᯒศ㔝ᑓ௵ᩍဨ࠾ࡼࡧ⫋ဨ࡟ࡈ┦ㄯୗࡉ࠸ࠋ

ᶵჾศᯒศ㔝ࡢᶵჾ࡟㛵ࡍࡿ㉁ၥ㸦඲⯡㸧ĺ ᶵჾศᯒศ㔝ᑓ௵ᩍဨ࠾ࡼࡧ⫋ဨ࡟ࡈ┦ㄯୗࡉ࠸ࠋ࡞࠾ࠊ
฼⏝⪅ࡀᶵჾศᯒศ㔝ࡢ࡝ࡢᶵჾࢆ฼⏝ࡋ࡚࡝ࡢࡼ࠺࡞
◊✲ࢆ⾜ࡗ࡚࠸ࡿ࠿࡟ࡘ࠸࡚ࡣᕳᮎࡢ฼⏝⪅◊✲ㄽᩥ୍ぴ㸦2021㸧ࢆࡈཧ↷ࡃࡔࡉ࠸ࠋ

ᶵჾศᯒศ㔝ࡢᶵჾࡢ⣽࠿࠸ᐃࡢࣀ࢘ࣁ࣭࢘౑⏝ᡭ㡰➼Ѝ ᶵჾศᯒศ㔝ᑓ௵ᩍဨࠊ⫋ဨ࠾ࡼࡧ༠ຊဨࡀ┦ㄯ࡟ᛂࡌࡲࡍࠋᶵჾศᯒศ㔝ࡢ㐠Ⴀ࡟㛵ࡍࡿࡈពぢ࣭ࡈ㉁ၥ➼Ѝ ᶵჾศᯒศ㔝ᑓ௵ᩍဨࠊ⫋ဨ࠶ࡿ࠸ࡣྛ㒊ᒁࡢ㐠Ⴀጤဨ࡟ࡈ㐃⤡ୗࡉ࠸ࠋ



2. ィ

ᶵჾࡢ฼⏝࡟㛵ࡍࡿ⏦ࡋྜࢃࡏᶵჾศᯒศ㔝

㸦㊃᪨㸧
➨ 1 ᮲ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝㸦௨ୗࠕᶵჾศᯒࠖ࡜࠸࠺ࠋ㸧࡟タ⨨ࡉࢀࠊู⾲ 1 ࡟ᐃࡵࡽࢀࡓィᶵჾ㸦㝃ᒓရࢆྵࡴࠋ௨ୗࠕィ ᶵჾࠖ࡜࠸࠺ࠋ㸧ࡢ฼⏝࡟ࡘ࠸࡚ࡣࠊ

ࡇࡢ⏦ࡋྜࢃࡏࡢᐃࡵࡿ࡜ࡇࢁ࡟ࡼࡿࡶࡢ࡜ࡍࡿࠋ㸦⟶⌮㸧
➨ 2 ᮲ ィ ᶵჾ࡜ࡑࡢ ᐃᐊཬࡧ ᐃ‽ഛᐊࡢ⟶⌮ࡣࠊศ㔝㛗ࡢ࿨࡟ࡼࡾᶵჾศᯒ⫋ဨཬࡧィ ᶵჾẖ࡟ᐃࡵࡽࢀࡓ༠ຊဨࡀ⾜࠺ࠋ㸦฼⏝⪅ࡢ㈨᱁㸧➨ 3 ᮲ ィ ᶵჾࢆ฼⏝࡛ࡁࡿ⪅ࡣࠊู⾲㸯࡟ᥖࡆࡓ฼⏝⪅ࡢ㈨᱁࡟ヱᙜࡍࡿ⪅࡜ࡍࡿࠋࡓࡔࡋࠊᶵჾ
ศᯒࡀ⾜࠺ㅮ⩦఍ࢆཷㅮࡋࡓ⪅࡟㝈ࡿࠋ㸦฼⏝ࡢ⏦ㄳ㸧➨ 4 ᮲ ィ ᶵჾࢆ฼⏝ࡋࡼ࠺࡜ࡍࡿ⪅ࡣᶵჾ฼⏝ㅮ⩦఍ཧຍ⏦ࡋ㎸ࡳཬࡧᶵჾ฼⏝⏦ㄳ᭩㸦ู⾲ 2㸧ࢆศ㔝㛗࡟ᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦฼⏝ࡢᢎㄆ㸧➨ 5 ᮲ ศ㔝㛗ࡣࠊ๓᮲ࡢ⏦ㄳࡀ㐺ᙜ࡛࠶ࡿ࡜ㄆࡵࡓ࡜ࡁ࡟ࡣࠊࡇࢀࢆᢎㄆࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸦ኚ᭦ࡢᒆฟ㸧➨ 6 ᮲ ๓᮲ࡢᢎㄆࢆᚓࡓ⪅ࡣࠊᶵჾ฼⏝ㅮ⩦఍ཧຍ⏦ࡋ㎸ࡳཬࡧᶵჾ฼⏝⏦ㄳ᭩ࡢグ㍕஦㡯࡟ኚ᭦ࡀ⏕ࡌࡓ࡜ࡁࡣࠊ㏿ࡸ࠿࡟ࡑࡢ᪨ࢆศ㔝㛗࡟ᒆࡅฟ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦฼⏝ᡭ⥆㸧➨㸵᮲ ฼⏝࡟ඛ❧ࡗ࡚ࠊ฼⏝⪅ࡣࠊ࠶ࡽ࠿ࡌࡵ฼⏝᪥᫬ࢆᶵჾศᯒ⫋ဨ࡟┦ㄯࡢ࠺࠼ࠊ ᐃ⏦㎸⡙࡟グධࡋண⣙ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2 ๓㡯ࡢண⣙ࢆኚ᭦ࠊⱝࡋࡃࡣ୰Ṇࡍࡿሙྜࡣ㐜⁫࡞ࡃᶵჾศᯒ⫋ဨ࡟ᒆࡅฟ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
3 ฼⏝⪅ࡣࠊ ᐃ⤊஢ᚋࠊ┤ࡕ࡟ᡤᐃࡢグ㘓⡙࡟฼⏝ࡢ㡯┠ࢆグධࡋࠊᐊෆࡢΎᤲᚋᶵჾศᯒ⫋ဨ࡟㐃⤡ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦ὀព⩏ົ㸧
➨ 8 ᮲ ฼⏝⪅ࡣࠊィ ᶵჾࡢṇᖖ㐠⏝ࡀ⥔ᣢࡉࢀࡿࡼ࠺୓඲ࡢὀពࢆᡶ࠸ࠊ࠿ࡘ ᐃ࡟㛵ࡍࡿᡤᐃࡢ
᧯సἲࢆཝᏲࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ୓୍ࠊ␗ᖖࢆㄆࡵࡓ࡜ࡁࡣࠊ┤ࡕ࡟ᶵჾศᯒ⫋ဨཪࡣ༠ຊဨ࡟
㐃⤡ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦⤒㈝ࡢ㈇ᢸ㸧➨9᮲ᐃ⤒㈝ࡣู⾲ 3 ࡟ᐃࡵࡿィ ᶵჾࡢ ᐃᩱ㔠࡟ࡼࡿࡶࡢ࡜ࡍࡿࠋ࡞࠾ண⣙᫬㛫ࢆࡶࡗ࡚౑⏝᫬㛫࡜ࡋࠊ㉸㐣ࡋࡓሙྜࡣ㉸㐣᫬㛫ࢆຍ⟬ࡍࡿࡶࡢ࡜ࡍࡿࠋ



2

฼⏝⪅ࡀࠊᨾពཪࡣ㐣ኻ࡟ࡼࡾࠊ⿦⨨ཬࡧ ᐃᐊ➼࡟㞀ᐖ࣭◚ᦆ➼ࢆᘬࡁ㉳ࡇࡋࡓሙྜࡣࠊ⌧≧࡟᚟ࡍࡿ㈝⏝ࢆ㈇ᢸࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

㸦฼⏝᫬㛫㸧
➨ 10 ᮲ ィᶵჾࡢ฼⏝᫬㛫ࡣཎ๎࡜ࡋ࡚ᶵჾศᯒࡢఇᴗ᪥௨እࡢู⾲ 1 ࡟ᐃࡵࡿ᫬㛫࡜ࡍࡿࠋࡓࡔࡋࠊᚲせ࡜ㄆࡵࡽࢀࡿሙྜࡣࡇࡢ㝈ࡾ࡛ࡣ࡞࠸ࠋ
2฼⏝⪅ࡀࠊ༗ᚋ㸳᫬࠿ࡽ⩣ᮅ༗๓㸷᫬ࡲ࡛ࡢ㛫࡟฼⏝ࢆᕼᮃࡍࡿሙྜࡣࠊ฼⏝ᙜ᪥ࡢ༗ᚋ 4 ᫬ࡲ࡛࡟ᚲࡎᶵჾศᯒ⫋ဨ࡟᫬㛫እ฼⏝ᒆ㸦ู⾲ 4㸧ࢆᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

㸦฼⏝ࡢྲྀᾘ➼㸧➨ 11 ᮲

฼⏝⪅ࡀࠊࡇࡢ⏦ࡋྜࢃࡏ࡟㐪཯ࡋࠊཪࡣ ᐃᶵჾࡢṇᖖ㐠⏝ࡢ⥔ᣢ࡟㔜኱࡞ᨭ㞀ࢆ⏕ࡌࡉࡏࡓሙྜࠊཪࡣࡑࡢ࠾ࡑࢀࡢ࠶ࡿሙྜࡣࠊศ㔝㛗ࡣ฼⏝ࡢᢎㄆࢆྲྀᾘࡋࠊཪࡣ୍ᐃᮇ㛫ࡢ฼⏝ࢆ೵Ṇࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
㸦㞧๎㸧
➨ 12 ᮲ ࡇࡢ⏦ࡋྜࢃࡏࡢᐇ᪋࡟㛵ࡋࠊᚲせ࡞஦㡯ࡣศ㔝㛗ࡀᐃࡵࡿࠋ
㝃๎ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᖹᡂ 16 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᖹᡂ 17 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᖹᡂ 18 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᖹᡂ 20 ᖺ 5 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᖹᡂ 22 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᖹᡂ 22 ᖺ 11 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃๎ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᖹᡂ 30 ᖺ 4 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋู⾲ 1 ฼⏝⪅㈨᱁
࠙ᰗᡞᆅ༊ࠚ
ィᶵჾྡ฼⏝⪅ࡢ㈨᱁㸦ὀ 1, 2, 3, 4㸧㸦␎⛠㸧฼⏝᫬㛫࠾ࡼࡧ㈚ฟࡋ
㸦ὀ 5, 6㸧⫋ဨ

㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾

JEM-2100◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕᭶᭙᪥㹼㔠᭙᪥

(STEM ྍ, EDX ௜)

㸦㈨᱁ࢆ᭷ࡍࡿᩍဨࡲࡓࡣ

9:00 㹼16:30

኱Ꮫ㝔⏕㸦ᩍ⫱Ꮫ㒊࠾ࡼࡧ㔠᭙᪥ࡢ 17:00 ࠿ࡽ᭶᭙(TEM)

ᆅᇦ⛉Ꮫ㒊ࡢሙྜࠊᏛ㒊⏕㸧 ᪥ࡢ 9:00 ㎾ࡣཎ๎࡜ࡋ࡚
H-7000ࡢ❧ࡕ఍࠸ࡢࡶ࡜࡛ 3 ࣨ᭶฼⏝࡛ࡁ࡞࠸ࠋ

௨ୖ౑⏝ࡋࡓ⪅㸧⫋ဨ◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕S-4300 (EDX ௜)㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾

S-4800 (EDX ௜)(SEM)

㸦㈨᱁ࢆ᭷ࡍࡿᩍဨࡲࡓࡣ
኱Ꮫ㝔⏕㸦ᩍ⫱Ꮫ㒊࠾ࡼࡧᆅᇦ⛉Ꮫ㒊ࡢሙྜࠊᏛ㒊⏕㸧ࡢ❧ࡕ఍࠸ࡢࡶ࡜࡛ 3 ࣨ᭶᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00

௨ୖ౑⏝ࡋࡓ⪅㸧
SEM-3000N (N-SEM)⫋ဨ◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕┿✵⵨╔⿦⨨㺂㺔㺼㺵㺛㺣㺐㺪స〇ჾ㺂㉸㺮㺖㺹㺢㺎㺯㺂㺡㺼㺆㺻㺪㺽㺷㺖㺼㺵㺐㺻㺞㺼㺎㺂㺐㺓㺻㺛㺨㺽㺍㺞㺂㺔㺎㺬㺼㺻㺘㺎㺞㺎㺂㺐㺓㺻㺮㺶㺻㺖㺼⿦⨨㺂⢭ᐦ㺐㺓㺻㺬㺽㺶㺍㺚㺻㺖㺼⿦⨨㺂㉸㡢Ἴ㺡㺼㺆㺛㺖㺔㺍㺞㺎㺂⫋ဨ◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕㺞㺼㺐㺏㺱㺻㺢㺼㺺㺐㺲㺎㺝㺎㺂㟁Ꮚ㢧ᚤ㙾㛵㐃
ᑠᆺᶵჾᑠᆺ㺛㺨㺽㺍㺞㺘㺎㺞㺎㺂㺪㺽㺵㺛㺼㺭᭶᭙᪥㹼㔠᭙᪥

㺖㺶㺎㺤㺻㺖㺼㺃㺔㺎㺬㺼㺻㺘㺎㺞㺎

9:00 㹼17:00

CT-UVBox⫋ဨ◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕㸦㈨᱁ࢆ᭷ࡍࡿᩍဨࡲࡓࡣ
㺦㺓㺓㺛㺮㺑㺯㺘㺎㺞㺎኱Ꮫ㝔⏕㸦ᩍ⫱Ꮫ㒊࠾ࡼࡧᆅᇦ⛉Ꮫ㒊ࡢሙྜࠊᏛ㒊⏕㸧ࡢ❧ࡕ఍࠸ࡢࡶ࡜࡛ 3 ࣨ᭶௨ୖ౑⏝ࡋࡓ⪅㸧ࢹࢪࢱ࣐ࣝ࢖ࢡࣟ
ࢫࢥ࣮ࣉ㉮ᰝᆺࣉ࣮ࣟࣈ
㢧ᚤ㙾ࢩࢫࢸ࣒
(SPM)⫋ဨ᭶᭙᪥㹼㔠᭙᪥

◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ
AFM5400L
AFM5300E⫋ဨ◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊
⏕௨ୖ



9:00 㹼17:00
᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00

⫋ဨX ⥺ග㟁Ꮚศᯒ⿦⨨◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕㸦㈨᱁ࢆ᭷ࡍࡿᩍဨࡲࡓࡣ

᭶᭙᪥㹼㔠᭙᪥

(XPS)

኱Ꮫ㝔⏕㸦ᩍ⫱Ꮫ㒊࠾ࡼࡧᆅᇦ⛉Ꮫ㒊ࡢሙྜࠊᏛ㒊⏕㸧

9:00 㹼17:00

ࡢ❧ࡕ఍࠸ࡢࡶ࡜࡛ 3 ࣨ᭶௨ୖ౑⏝ࡋࡓ⪅㸧
GC-MDWHჟ㧗ศゎ⬟㉁㔞ศᯒ⿦⨨ (MS)

JMS-700.
AccuTOFAXIMAᾮయࢡ࣐ࣟࢺࢢࣛࣇ
(HPLC)

Agilent1100

᭶᭙᪥㹼㔠᭙᪥㈨᱁ࢆ᭷ࡍࡿᩍဨࡀㄆࡵࡓ
኱Ꮫ㝔ࡢᏛ⏕࠾ࡼࡧᏛ㒊⏕᭶᭙᪥㹼㔠᭙᪥

nanoLC

9:00 㹼20:00

EXTREMAJNM ECA 500⫋ဨࠊJNM ECX400P◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊ඹ㬆⿦⨨

JNM ECZ600R/M1⏕௨ୖ(FT-NMR)JNM ECA 500⫋ဨࠊ

NM-93030CPM㸦ᅛయ㸧኱Ꮫ㝔ࡢᏛ⏕

ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽ㟁Ꮚࢫࣆࣥඹ㬆⿦⨨ (ESR)

9:00 㹼17:00⫋ဨࠊ᭶᭙᪥㹼㔠᭙᪥
9:00 㹼20:00⫋ဨ◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ⿦⨨ (ICP-AES)࣐࢖ࢡࣟἼศᯒ๓ฎ⌮⿦⨨ (MARS6)Ἴ㛗ศᩓᆺ⺯ග X ⥺ศᯒ⿦⨨ (XRF)⫋ဨࠊ◊✲ᐊ࡟ᡤᒓࡋ࡚࠸
ࡿᏛ㒊⏕௨ୖ
᭶᭙᪥㹼㔠᭙᪥
⫋ဨࠊ኱Ꮫ㝔ࡢᏛ⏕᭷ᶵᚤ㔞ඖ⣲ศᯒ⿦⨨ (OEA)

9:00 㹼17:00◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕ࡣࠊᣦᑟᩍဨࡀ≉࡟チྍࡋࡓ⪅᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00㉸㧗㏿ᗘ᧜ᙳ⿦⨨㈚ฟࡋ㸸1 ᪥࠾ࡼࡧ 1 㐌㛫

(UHC)༢఩࡛᭱኱ 2 㐌㛫ࡲ࡛ᘏ㛗ྍ㉸㧗㏿ᗘ⌧㇟

ỗ⏝㧗㏿ᗘ᧜ᙳ⿦⨨⫋ဨࠊ኱Ꮫ㝔ࡢᏛ⏕࠾ࡼࡧ

(HV)ᮏᏛ⫋ဨ❧ࡕ఍࠸ࡢࡶ࡜ࠊ

ゎᯒࢩࢫࢸ࣒ᪧ⿦⨨㈚ฟࡋ㸸᭱㛗 2 ࣨ᭶(4 ᭶㹼9 ᭶)ࠊ
᭱㛗 1 ࠿᭶(10 ᭶㹼3 ᭶)◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊᭶᭙᪥㹼㔠᭙᪥

⏕9:00 㹼17:00㈚ฟࡋ㸸1 ᪥࠾ࡼࡧ 1 㐌㛫ࣃࣝࢫࢪ࢙ࢿ࣮ࣞࢱ

༢఩࡛᭱኱ 2 㐌㛫ࡲ࡛ᘏ㛗

(PG)

ྍཎ๎࡜ࡋ࡚ PG ༢⊂ࡢ㈚ฟ
ࡋࡣ⾜ࢃ࡞࠸ࠋ

᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00㈚ฟࡋ㸸1 ᪥࠾ࡼࡧ 1 㐌㛫㉥እ⥺࣓࢝ࣛ

༢఩࡛᭱኱ 2 㐌㛫ࡲ࡛ᘏ㛗(TC)ྍᪧ⿦⨨㈚ฟࡋ㸸᭱㛗 2 ࣨ᭶(4 ᭶㹼9 ᭶)ࠊ
᭱㛗 1 ࠿᭶(10 ᭶㹼3 ᭶)⣸እྍどศග
ගᗘィ (UV-Vis)⫋ဨ᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ
㏱㐣ᆺࣇ࣮࢚ࣜኚ᥮ᆺ
㉥እศගගᗘィ(FT-IR)⫋ဨ㢧ᚤ࣭཯ᑕᆺ

᭶᭙᪥㹼㔠᭙᪥

◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊

In Situ ࣉ࣮ࣟࣈᘧ

9:00 㹼17:00⏕௨ୖ㢧ᚤ࣭᥋ゐᆺ
᪕ගィ෇஧Ⰽᛶศᩓィ(CD)⫋ဨ᭶᭙᪥㹼㔠᭙᪥

⫋ဨ᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ
⺯ගᑑ࿨

ᐃ⿦⨨

㸦Tau㸧
⺯ගศගගᗘィ

9:00 㹼17:00◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ⫋ဨ⤯ᑐ PL 㔞Ꮚ཰⋡ᐃ⿦⨨㸦QY㸧

᭶᭙᪥㹼㔠᭙᪥

◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕

9:00 㹼17:00

௨ୖศග⺯ගගᗘィ㸦FL㸧
᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00

ࣇ࢙࣒ࢺ⛊

⫋ဨ

ࣇ࢓࢖ࣂ࣮࣮ࣞࢨ࣮

◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ㈚ฟࡋ㸸1 ᪥࠾ࡼࡧ 1 㐌㛫༢఩࡛᭱኱ 2 㐌㛫ࡲ࡛ᘏ㛗ྍࢸࣛ࣊ࣝࢶศග

⫋ဨ㉮ᰝᆺ㢧ᚤ㙾

◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ㢧ᚤ࣮ࣞࢨ࣮࣐ࣛࣥ

᭶᭙᪥㹼㔠᭙᪥

⫋ဨ

9:00 㹼17:00
᭶᭙᪥㹼㔠᭙᪥

ศගࢩࢫࢸ࣒

◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ⇕ศᯒࢩࢫࢸ࣒

⫋ဨࠊ኱Ꮫ㝔ࡢᏛ⏕(DSC, TMA,◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕ࡣࠊᣦᑟᩍဨࡀ≉࡟チྍ

TG/DTA)ࡋࡓ⪅

9:00 㹼17:00
᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00

ࣇ࣮ࣟᘧ⢏Ꮚീศᯒ
⿦⨨⢏Ꮚ࣭⢓ᙎᛶ

⢏Ꮚᚄ࣭ࢮ࣮ࢱ㟁⫋ဨゎᯒࢩࢫࢸ࣒

఩࣭ศᏊ㔞◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊

ᐃ⿦⨨

⏕௨ୖ
࣓࣮ࣞ࢜ࢱ࣮
ືⓗ⢓ᙎᛶ

ᐃ⿦⨨



᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00

⫋ဨ༤ኈㄢ⛬(ᕤᏛ㒊࡟᪊࠸࡚ࡣ༤ኈᚋᮇㄢ⛬)ࡢᏛ⏕X ⥺࣐࢖ࢡࣟ

ಟኈ(༤ኈㄢ⛬๓ᮇ)ㄢ⛬ࡣᣦᑟᩍဨࡀ௵࿨ࡋࡓ◊✲ᐊCT ࢫ࢟ࣕࢼ࣮

௦⾲⪅㸧᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕㸦3 ࣨ᭶௨ୖ౑⏝ࡋࡓ⪅࡛ࠊ㈨᱁ࢆ᭷ࡍࡿᩍဨࡀㄆࡵࡓࡶࡢ㸧ὀ 1㸸฼⏝⪅ࡣࠊศ㔝㛗ࡀ≉࡟㐺ᙜ࡜ㄆࡵࡓ⪅ࢆ฼⏝ྍ⬟࡜ࡍࡿࠋὀ 2㸸࠸ࡎࢀࡶ኱Ꮫ㝔ࡢᏛ⏕࡟ࡣࠊ6 ᖺㄢ⛬ࡢᏛ㒊࠾ࡼࡧᏛ⛉࡟ᡤᒓࡍࡿ 5ࠊ6 ᖺ⏕ࢆྵࡴࠋὀ 3㸸ᮏ኱Ꮫ࡜ࢭࣥࢱ࣮ࡢ฼⏝࡟㛵ࡋ࡚ྲྀࡾỴࡵࢆ⾜ࡗ࡚࠸ࡿ኱Ꮫ➼ࡢᶵ㛵ࡢᩍဨ࠾ࡼࡧᏛ⏕࡟ࡘ࠸࡚ࡶࠊ
ᮏᏛࡢ฼⏝㈨᱁࡟‽ࡎࡿ
ὀ 4㸸㈨᱁⪅࡜ࡣࠊ3 ࠿᭶௨ୖࡢ౑⏝⤒㦂ࢆᣢࡕࠊᩍဨ࠿ࡽ༢⊂౑⏝ࢆㄆࡵࡽࢀࡓࡶࡢ࡜ࡍࡿࠋ
ὀ 5㸸17:00 ௨㝆ࡢ฼⏝ᕼᮃ⪅ࡣࠕ᫬㛫እ฼⏝ᒆࠖࢆ 16:00 ㎾࡟ᥦฟୗࡉ࠸ࠋ
ὀ 6㸸㈚ฟࡋ࡟㝿ࡋ࡚ࡣᮏᏛ⫋ဨࡢ❧ࡕ఍࠸ࡢࡶ࡜࡟⾜࠺ࡇ࡜ࠋ2 㐌㛫ࢆ㉺࠼࡚ࡉࡽ࡟㈚ฟࡋ฼⏝ࢆᕼᮃࡍࡿሙྜࡣᨵࡵ࡚⏦ㄳࡍࡿࡇ࡜ࠋ

࠙་Ꮫᆅ༊ࠚ
ィᶵჾྡ฼⏝⪅ࡢ㈨᱁㸦ὀ 1, 2, 3㸧㸦␎⛠㸧ࣇ࣮࢚ࣜኚ᥮
᰾☢Ẽඹ㬆⿦⨨(FT-NMR)㟁Ꮚࢫࣆࣥඹ㬆⿦⨨ (ESR)$9$1&(რ
$9$1&(რ

ᮏᏛ⫋ဨࠊࢭࣥࢱ࣮ᩍဨ࠾
ࡼࡧᣦᑟᩍဨࡀチྍࡋࡓ኱Ꮫ㝔⏕⫋ဨ฼⏝᫬㛫㸦ὀ 4㸧᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00
᭶᭙᪥㹼㔠᭙᪥

◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ

9:00 㹼17:00

ᮏᏛࡢ⫋ဨ༤ኈㄢ⛬(ᕤᏛ㒊࡟᪊࠸࡚ࡣ༤ኈᚋᮇㄢ⛬)ࡢᏛ⏕ಟኈ㉸㧗㍤ᗘ X ⥺ᅇᢡ⿦⨨ (XRD)(༤ኈㄢ⛬๓ᮇ)ㄢ⛬ࡣᣦᑟᩍဨࡀ௵࿨ࡋࡓ◊✲ᐊ௦⾲᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00⪅㸧฼⏝ࡍࡿ๓࡟ࠊᨺᑕ⥺సᴗᚑ஦⪅ࡢㅮ⩦఍ࢆཷㅮࡍࡿࡇ࡜ὀ 1㸸฼⏝⪅ࡣࠊศ㔝㛗ࡀ≉࡟㐺ᙜ࡜ㄆࡵࡓ⪅ࢆ฼⏝ྍ⬟࡜ࡍࡿࠋὀ 2㸸࠸ࡎࢀࡶ኱Ꮫ㝔ࡢᏛ⏕࡟ࡣࠊ6 ᖺㄢ⛬ࡢᏛ㒊࠾ࡼࡧᏛ⛉࡟ᡤᒓࡍࡿ 5ࠊ6 ᖺ⏕ࢆྵࡴࠋὀ 3㸸ᮏ኱Ꮫ࡜ࢭࣥࢱ࣮ࡢ฼⏝࡟㛵ࡋ࡚ྲྀࡾỴࡵࢆ⾜ࡗ࡚࠸ࡿ኱Ꮫ➼ࡢᶵ㛵ࡢᩍဨ࠾ࡼࡧᏛ⏕࡟ࡘ࠸࡚ࡶࠊ
ᮏᏛࡢ฼⏝㈨᱁࡟‽ࡎࡿࠋὀ 4㸸17:00 ௨㝆ࡢ฼⏝ᕼᮃ⪅ࡣࠕ᫬㛫እ฼⏝ᒆࠖࢆ 16:00 ㎾࡟ᥦฟୗࡉ࠸ࠋ



ู⾲ 2

௧࿴㻠ᖺᗘ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊ᶵჾศᯒศ㔝ᶵჾ฼⏝⏦ㄳ᭩ཬ䜃ᶵჾ฼⏝ㅮ⩦఍ཧຍ⏦䛧㎸䜏ᒱ㜧኱Ꮫ䚷㧗➼◊✲㝔䚷⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊ᶵჾศᯒศ㔝㛗䚷Ẋୗグ䛾㏻䜚ᶵჾศᯒศ㔝ᶵჾ䜢฼⏝䛧䛯䛔䛾䛷䚸ㅮ⩦఍䛻ཧຍ䛧䛯ᚋ䚸ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊ᶵჾศᯒศ㔝฼⏝つ๎䜢㑂Ᏺ䛧䚸⏦ㄳ䛧䜎䛩䚹

䠄Ặྡ䠅
䠄ᡤᒓ䠅

䠄⫋ྡ䠅
Ꮫ㒊

Ꮫ⛉

ㅮᗙ䞉䝁䞊䝇ྡᣦᑟᩍဨ䠄㐃⤡㈐௵⪅䠅㼀㻱㻸䠖㟁Ꮚ䝯䞊䝹䜰䝗䝺䝇

䠄

䠅

䠄Ặྡ䠅

⤒㈝㈇ᢸ

䠄ᡤᒓ䠅

䠄⫋ྡ䠅
Ꮫ㒊

Ꮫ⛉

ㅮᗙ䞉䝁䞊䝇ྡ

㈐䚷௵䚷⪅
㼀㻱㻸䠖

฼ ⏝㻌ᕼ㻌ᮃ
ᶵ ჾ䚷ྡ
Ặ䚷䚷䚷ྡ

⫋ྡ䠄Ꮫᖺ䠅

ෆ⥺㟁Ꮚ䝯䞊䝹䜰䝗䝺䝇 ㅮ⩦఍ཧຍᕼᮃ䛚䜘䜃ཷㅮ῭⪅

ഛ⪃

⏦䚷ㄳ䚷⪅

ᶵჾศᯒศ㔝グධḍ

ཷ௜␒ྕ

ཷ௜᪥

䛚㢪䛔
䛺䛚䚸ᮏ◊✲䛻㛵䛧䛶Ⓨ⾲䛧䛯ㄽᩥ䛻䛿౑⏝䛧䛯ᶵჾศᯒศ㔝䛾ᶵჾྡ䜢᫂グ䛩䜛䛣䛸䛸䛧䚸ㄽᩥูๅ䜚㻝㒊䜎䛯䛿㟁Ꮚ䝣䜯䜲䝹䜢ᶵჾศᯒศ㔝䛻ᥦฟ䛻䛤༠ຊ䜢䛚㢪䛔䛔䛯䛧䜎䛩䚹ᒱ㜧኱Ꮫ䚷㧗➼◊✲㝔䚷⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊䚷ᶵჾศᯒศ㔝㛗ὀព

1 ᶵჾ䛾౑⏝䛻ᙜ䛯䛳䛶䛿䠈ᶵჾ䛤䛸䛾౑⏝⏦㎸᭩䜢ู㏵ᥦฟ䛧䛶䛟䛰䛥䛔䚹䠄㻺㻹㻾㻠㻜㻜䞉㻡㻜㻜䞉ᅛయ䞉㻢㻜㻜㻹㻴㼦㻠ྎ฼⏝䛩䜛䛸䛔䛳䛯ሙྜ䚸䛭䜜䛮䜜ู䛻ᥦฟ䛧䛶ୗ䛥䛔䠅
2 䛣䛾⏦ㄳ᭩䛻Ⓩ㘓䠄Ặྡ䠅䛾↓䛔᪉䛿฼⏝䛷䛝䜎䛫䜣䚹䜎䛯䠈ᶵჾ౑⏝䛩䜛䛻䛿ᩍဨ䛜ㅮ⩦఍῭䜏䜎䛯䛿ཧຍᕼᮃ䛩䜛䛣䛸䜢ཎ๎䛸䛧䜎䛩䚹ㅮ⩦఍䛾᪥⛬䛿㐃⤡㈐௵⪅ᐄ䛻㼑㻙㼙㼍㼕㼘䛷㐃⤡䛧䜎䛩䚹
3 䝉䞁䝍䞊䛾฼⏝ᮇ㛫䛿ᙜヱᖺᗘෆ䛸䛧䛶䛟䛰䛥䛔䚹4 ᪂つ฼⏝⪅ཪ䛿䝟䝇䝽䞊䝗ኚ᭦ᕼᮃ⪅䛿ୗ䛾ḍ䜢グධ䛧䛶䛟䛰䛥䛔䚹䠄⿦⨨䛾ண⣙䛻䝻䜾䜲䞁㻵㻰䛸䝟䝇䝽䞊䝗䛜ᚲせ䛷䛩䚹ⱥᩘᏐ㻢ᩥᏐ௨ୖ䛷タᐃ䛧䛶䛟䛰䛥䛔䚹䠅䝻䜾䜲䞁㻵㻰

䝟䝇䝽䞊䝗



ู⣬
Ặ䚷䚷䚷ྡ

⫋ྡ䠄Ꮫᖺ䠅

ෆ⥺㟁Ꮚ䝯䞊䝹䜰䝗䝺䝇 ㅮ⩦఍ཧຍᕼᮃ䛚䜘䜃ཷㅮ῭⪅

⏦䚷ㄳ䚷⪅



ഛ⪃

ู⾲ 4.

ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝㸦ᰗᡞᆅ༊㸧᫬㛫እ฼⏝ᒆ
ᣦᑟᩍဨྡ
ᅾ

༳

Ꮫ㒊
Ꮫ⛉

ᐊ
⪅

ㅮᗙ
ෆ⥺

㌟ศ㸦Ꮫᖺ㸧

Ặྡ㸯㸬㉁㔞ศᯒ⿦⨨㸦JMS-700, JMS-.*&PDWHჟ㸪AccuTOF, ᾮࢡࣟ, AXIMA, NanoLC㸧㸰㸬ࣇ࣮࢚ࣜኚ᥮㉸ఏᑟ᰾☢Ẽඹ㬆⿦⨨㸦FT-NMRࣇ࣮࢚ࣜኚ᥮㉸ఏᑟ᰾☢Ẽඹ㬆⿦⨨㸦FT-NMR

౑⏝ࡍࡿᶵ
ჾࡢ␒ྕ࡟
ࠐࢆࡘࡅ࡚
ࡃࡔࡉ࠸ࠋ

400࣭600 MHz㸧500 MHz࣭ᅛయ㸧㸱㸬㢧ᚤ࣮ࣞࢨ࣮࣐ࣛࣥศගࢩࢫࢸ࣒
㸲㸬᭷ᶵᚤ㔞ඖ⣲ศᯒ⿦⨨㸳㸬⣸እྍどศගගᗘィ㸦UV㸧㸴㸬㉥እศගගᗘィ㸦ࣃ࣮࢟ࣥ,᪥ᮏศග㸧㸵㸬෇஧Ⰽᛶศᩓィ㸦CD㸧㸶㸬⇕ศᯒࢩࢫࢸ࣒㸦DSC㸪TG/DTA㸪TMA㸧
㸷㸬⢏Ꮚᚄ࣭ࢮ࣮ࢱ㟁఩࣭ศᏊ㔞 ᐃ⿦⨨㸯㸮㸬ࣇ࣮ࣟᘧ⢏Ꮚീศᯒ⿦⨨㸯㸯㸬᪕ගィ
㸯㸰㸬࣓࣮ࣞ࢜ࢱ࣮࣭ືⓗ⢓ᙎᛶ ᐃ⿦⨨㸯㸱㸬㉥እศගගᗘィ㸦Illuminat IR, React IR㸧㸯㸲㸬PL 㔞Ꮚ཰⋡࣭⺯ගᑑ࿨ ᐃ⿦⨨㸯㸳㸬ศග⺯ගගᗘィ㸯㸴㸬⢭ᐦኳ⛗㸯㸵㸬㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾㸦TEM ᪥ᮏ㟁Ꮚ㸧
㸯㸶㸬㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾㸦TEM ᪥❧㸧㸯㸷㸬㟁Ꮚ㢧ᚤ㙾㸦SEM4800, SEM4300, SEM3000㸧㸰㸮㸬⵨╔⿦⨨࣭࢖࢜ࣥࢫࣃࢵࢱ࣮࣭ࢹ࢕ࣥࣉࣝࢢࣛ࢖ࣥࢲ࣮࣭࢖࣑࢜ࣥࣜࣥࢢ⿦⨨࣭⢭ᐦ࢖࣏࢜ࣥࣜࢵࢩࣥࢢ࣭ࢿ࢜࢜ࢫ࣑࣒࢘ࢥ࣮ࢱ࣮࣭࢖࢜ࣥࢥ࣮ࢱ࣮࣭࣮࢝࣎ࣥ
ࢥ࣮ࢱ࣮࣭ࢲ࢖ࣖࣔࣥࢻ࣡࢖࣮ࣖࢯ࣮
㸰㸯㸬㉮ᰝᆺࣉ࣮ࣟࣈ㢧ᚤ㙾㸦SPM㸧
㸰㸰㸬࣑ࢡࣟࢺ࣮࣒࣭࣓ࢵࢧ࣮
㸰㸱㸬ࢹࢪࢱ࣐ࣝ࢖ࢡࣟࢫࢥ࣮ࣉ
㸰㸲㸬㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦ESR㸧㸰㸳㸬X ⥺ග㟁Ꮚศᯒ⿦⨨㸦Quantera㸧㸰㸴㸬ㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ⿦⨨㸦ICP-AES㸧㸰㸵㸬࣐࢖ࢡࣟἼศᯒ๓ฎ⌮⿦⨨㸦MARS6㸧㸰㸶㸬X ⥺࣐࢖ࢡࣟ CT ࢫ࢟ࣕࢼ࣮
㸰㸷㸬⺯ග X ⥺ศᯒ ⿦⨨㸦XRF㸧
㸱㸮㸬X ⥺ᅇᢡ⿦⨨㸦SmartLab㸧㸱㸯㸬ࢸࣛ࣊ࣝࢶศග㉮ᰝᆺ㢧ᚤ㙾㸱㸰㸬ࣇ࢙࣒ࢺ⛊ࣇ࢓࢖ࣂ࣮࣮ࣞࢨ࣮

฼⏝᪥᫬

᭶

᪥㸦

㸧

᫬

ศ

᭶

᪥㸦

㸧

᫬

ศ



㹼

ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝㸦་Ꮫᆅ༊㸧᫬㛫እ฼⏝ᒆ
ᣦᑟᩍဨྡ

༳

Ꮫ
㒊
ᅾ
ᐊ
⪅

Ꮫ
⛉
ㅮ
ᗙ
ෆ
⥺

㌟ศ㸦Ꮫᖺ㸧

Ặྡ㸯㸬ࣇ࣮࢚ࣜኚ᥮㉸ఏᑟ᰾☢Ẽඹ㬆⿦⨨㸦FT-NMR

600 MHz㸧㸰㸬ࣇ࣮࢚ࣜኚ᥮㉸ఏᑟ᰾☢Ẽඹ㬆⿦⨨㸦FT-NMR

800 MHz㸧㸱㸬㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦ESR㸧

౑⏝ࡍࡿᶵ
ჾࡢ␒ྕ࡟
‫࡚ࡅࡘࢆۑ‬ࡃࡔࡉ࠸ࠋ㸲㸬㉸㧗㍤ᗘ X ⥺ᅇᢡ⿦⨨

᭶

᪥㸦

㸧

᫬

ศ

᭶

᪥㸦

㸧

᫬

ศ

฼⏝᪥᫬



㹼

3. ཷクヨ㦂࡟ࡘ࠸࡚ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝ཷクヨ㦂㸪 ᐃཬࡧ᳨ᰝ➼ྲྀᢅせ㡯
䠄㊃᪨㸧➨㸯᮲ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㸦௨ୗࠕࢭࣥࢱ࣮㺁࡜࠸࠺ࠋ㸧࡟࠾࠸࡚㸪ᮾᾏᅜ❧኱Ꮫᶵᵓཷク◊✲つ⛬➨㸰㸲᮲➨㸲㡯࡟ᇶ࡙ࡁ⾜࠺ᐃᆺⓗ࡞ヨ㦂㸪 ᐃཬࡧ᳨ᰝ➼ࡢཷク◊✲㸦௨ୗࠕヨ㦂➼ࠖ࡜࠸࠺ࠋ
㸧ࡢྲྀᢅ࠸࡟ࡘ࠸࡚ࡣ㸪ࡇࡢせ㡯ࡢᐃࡵࡿ࡜ࡇࢁ࡟ࡼࡿࠋ
㸦⏦㎸ࡳࡢ᪉ἲ㸧➨㸰᮲ ヨ㦂➼ࡢ⏦㎸ࡳࡣ㸪ู⣬ᵝᘧ➨㸯ྕ࡟ࡼࡾ⾜࠺ࡶࡢ࡜ࡍࡿࠋ
㸦ཷධ᮲௳㸧
➨㸱᮲ ヨ㦂➼ࡢཷධࢀࡢ᮲௳ࡣ㸪ḟࡢྛྕ࡟ᥖࡆࡿࡶࡢ࡜ࡍࡿࠋ୍ ➨㸴᮲࡟ᐃࡵࡿヨ㦂➼ࡢᩱ㔠ࡣཎ๎࡜ࡋ࡚๓⣡ࡍࡿࡶࡢ࡜ࡍࡿࠋࡓࡔࡋ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗㸦௨ୗࠕࢭࣥࢱ࣮㛗ࠖ࡜࠸࠺ࠋ㸧ࡀ≉ูࡢ஦⏤ࡀ࠶ࡿ࡜ㄆࡵࡓሙྜ࡟ࡣᚋ⣡࡜ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ஧ ጤク⪅࠿ࡽࡢ⏦ࡋฟ࡟ࡼࡾヨ㦂➼ࢆ୰Ṇࡋࡓሙྜ࡟࠾࠸࡚ࡶᩱ㔠ࡣ㏉㑏ࡋ࡞࠸ࠋࡓࡔࡋ㸪≉ูࡢ஦᝟ࡀ࠶ࡿሙྜ࡟ࡣ㸪ࡑࡢ඲㒊ࡲࡓࡣ୍㒊ࢆ㏉㑏ࡍࡿࡇ࡜ࡀ࠶ࡿࠋ
ḟ࡟ᥖࡆࡿሙྜ࡟ࡣ㸪ጤク⪅ࡢཷࡅࡿᦆᐖ࡟ᑐࡋ࡚ࢭࣥࢱ࣮ࡣࡑࡢ㈐௵ࢆ㈇ࢃ࡞࠸ࠋ
࢖ ࡸࡴࢆᚓ࡞࠸஦⏤࡟ࡼࡗ࡚ヨ㦂➼ࢆ୰Ṇࡋࡓࡓࡵᦆᐖࡀ⏕ࡌࡓ࡜ࡁࠋࣟ ヨ㦂➼ࢆ⾜࠺ࡓࡵ࡟ᥦฟࡉࢀࡓᮦᩱ➼㸦௨ୗࠕᮦᩱ➼ࠖ࡜࠸࠺ࠋ
㸧࡟ᦆᐖࡀ⏕ࡌࡓ࡜ࡁࠋࣁ ➨භྕࡢሙྜ࡟࠾࠸࡚㸪ࢭࣥࢱ࣮ࡢᶵჾ➼ࢆ౑⏝ࡍࡿ⪅ࡢ㈐࡟ࡼࡿ஦⏤࡟ࡼࡗ࡚ᦆᐖࡀ⏕ࡌࡓ࡜ࡁࠋ୕ ヨ㦂➼ࡢᐇ᪋ୖࢭࣥࢱ࣮㛗ࡀᚲせ࡜ㄆࡵࡓ࡜ࡁࡣ㸪ᮦᩱ➼ࡢ෌ᥦฟࢆồࡵࡿࡇ࡜ࡀ࡛ࡁࡿࠋᅄ ᮦᩱ➼ࡢᦙධཬࡧᦙฟࡣ㸪ࡍ࡭࡚ጤク⪅ࡀ⾜࠺ࡶࡢ࡜ࡍࡿࠋ஬ ࢭࣥࢱ࣮㛗ࡀཷධࢀ࡛ࡁ࡞࠸࡜ุ᩿ࡋࡓᮦᩱ➼࡟ಀࡿヨ㦂➼࡟ࡘ࠸࡚ࡣ㸪ཷධࢀࢆࡋ࡞࠸ࡇ
࡜ࡀ࡛ࡁࡿࠋභ ጤク⪅ࡀᏛෆᢸᙜ⪅ࡢᣦᑟ࣭❧఍ࡢୗ࡛┤᥋ࢭࣥࢱ࣮ࡢᶵჾ➼ࢆ౑⏝ࡍࡿሙྜࡣ㸪ู⣬ᵝᘧ➨㸰ྕࡢ౑⏝⏦ㄳ᭩ࢆᥦฟࡋ㸪ྠ᭩ࡢ☜ㄆ஦㡯ࢆ㑂Ᏺࡋヨ㦂➼ࢆ⾜࠺ࡇ࡜࡜ࡍࡿࠋࡓࡔࡋࠊ౑
⏝⪅ࡣࠊࢭࣥࢱ࣮ࡀ⾜࠺ᶵჾศᯒࡢ౑⏝࡟㛵ࡍࡿㅮ⩦఍ࢆཷㅮࡋࡓ⪅࡟㝈ࡿࠋ㸦ཷධࢀཬࡧ⤖ᯝࡢ㏻▱)➨㸲᮲ ヨ㦂➼ࡢཷධࢀཬࡧࡑࡢ⤖ᯝࡢ㏻▱ࡣ㸪ࢭࣥࢱ࣮㛗ࡢᐃࡵࡿᡭ⥆ࢆ⤒࡚⾜࠺ࡶࡢ࡜ࡍࡿࠋ
㸦⛎ᐦࡢಖᣢ➼㸧➨㸳᮲ ࢭࣥࢱ࣮ཬࡧጤク⪅ࡣࠊヨ㦂➼ࡢᐇ᪋࡛▱ࡾᚓࡓ┦ᡭ᪉ࡢ⛎ᐦ㸪▱ⓗ㈈⏘➼ࢆ┦ᡭ᪉ࡢ᭩㠃࡟ࡼࡿྠព࡞ࡋ࡟බ㛤ࡋ࡚ࡣ࡞ࡽ࡞࠸ࠋ
㸰ᐃ࡛ᚓࡽࢀࡓࢹ࣮ࢱࢆጤク⪅ࡀබ⾲ࡍࡿሙྜ㸪ཎ๎࡜ࡋ࡚ᒱ㜧኱Ꮫྡࢆ౑⏝ࡍࡿࡇ࡜ࡣ࡛ࡁ
࡞࠸ࠋࡲࡓࠊᒱ㜧኱Ꮫࢆ≉ᐃ࡛ࡁࡿ⾲⌧ࡶྠᵝ࡜ࡍࡿࠋࡓࡔࡋࠊࢭࣥࢱ࣮㛗ࡀ኱Ꮫྡࡢ౑⏝ࢆチྍࡋࡓሙྜ࡟ࡣࡇࡢ㝈ࡾ࡛ࡣ࡞࠸ࠋ
㸦ヨ㦂➼ࡢᩱ㔠㸧➨㸴᮲ ヨ㦂➼ࡢᩱ㔠ࡣ㸪ู⾲ࡢ࡜࠾ࡾ࡜ࡍࡿࠋࡓࡔࡋ㸪◊✲ᩍ⫱ୖࢭࣥࢱ࣮㛗ࡀᚲせ࡜ㄆࡵࡓヨ㦂➼ࡢࡓࡵࡢᮦᩱ➼ࡢᥦ౪ࢆせㄳࡋࡓሙྜ࡟ࡣᩱ㔠ࢆ཰⣡ࡋ࡞࠸ࡇ࡜ࡀ࡛ࡁࡿࠋ㸰 ヨ㦂➼ࡢᩱ㔠ࡣ㸪ᮾᾏᅜ❧኱ᏛᶵᵓࡀⓎ⾜ࡍࡿㄳồ᭩࡟ࡼࡾ཰⣡ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸯㸴ᖺ㸲᭶㸯᪥࠿ࡽᐇ᪋ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸰㸮ᖺ㸲᭶㸯᪥࠿ࡽᐇ᪋ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸰㸮ᖺ㸯㸯᭶㸰㸴᪥࠿ࡽᐇ᪋ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸰㸰ᖺ㸯㸯᭶㸰㸲᪥࠿ࡽᐇ᪋ࡍࡿࠋ



㝃 ๎
ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸰㸱ᖺ㸵᭶ 1 ᪥࠿ࡽᐇ᪋ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸰㸴ᖺ㸲᭶㸰㸶᪥࠿ࡽᐇ᪋ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸰㸵ᖺ㸯᭶㸰㸱᪥࠿ࡽᐇ᪋ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸰㸵ᖺ㸵᭶㸰㸰᪥࠿ࡽᐇ᪋ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪ᖹᡂ㸱㸮ᖺ㸳᭶㸷᪥࠿ࡽ᪋⾜ࡋ㸪ᖹᡂ㸱㸮ᖺ㸲᭶㸯᪥࠿ࡽ㐺⏝ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪௧࿴㸰ᖺ㸵᭶㸶᪥࠿ࡽ᪋⾜ࡋ㸪௧࿴㸰ᖺ㸲᭶㸯᪥࠿ࡽ㐺⏝ࡍࡿࠋ㝃 ๎ࡇࡢせ㡯ࡣ㸪௧࿴㸱ᖺ㸳᭶㸯㸰᪥࠿ࡽᐇ᪋ࡍࡿࠋ

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ู⾲

ヨ㦂➼ࡢᇶᮏ฼⏝ᩱ㔠㸦ὀ 1, 2㸧࠙ᰗᡞᆅ༊ࠚ
ᶵ

ჾ

ྡ

ᩘ

㔞

ᩱ

㔠 㸦෇㸧

㟁Ꮚ㢧ᚤ㙾
㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾 㸦TEM㸧㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾 㸦SEM㸧

ᇶᮏ

1 ᳨య

42,000

ᐃ1௳

20,000ࡑࡢ௚≉Ṧࢹࢪࢱ࣐ࣝ࢖ࢡࣟࢫࢥ࣮ࣉ

ᐃ

ᛂ┦ㄯ

ᐃ1௳

21,000ᐃ 1 ᳨య

10,000ᇶᮏ㉮ᰝᆺࣉ࣮ࣟࣈ㢧ᚤ㙾 㸦SPM㸧

ᇶᮏ

ࡑࡢ௚≉Ṧ

ᐃ

ᛂ┦ㄯ

㉮ᰝᆺ X ⥺ග㟁Ꮚศගศᯒ⿦⨨ Quantera-SXM
40,000㸦࣡࢖ࢻࢫ࢟ࣕࣥࢆྵࡴ㸪4 ඖ⣲ࡲ࡛㸧ࡑࡢ௚ࡢ≉Ṧᐃᛂ┦ㄯ㉁㔞ศᯒ⿦⨨
పศゎ⬟

ᐃ

1 ᳨య

21,000

㧗ศゎ⬟

ᐃ

1 ᳨య

30,00024 ᫬㛫ࡈ࡜

30,000

H-NMR

1 ᳨య

22,000

C-NMR

1 ᳨య

30,000

2D NMR 㸦COSY㸧

1 ᳨య

43,000㉁㔞ศᯒ⿦⨨⏝ᾮయࢡ࣐ࣟࢺࢢࣛࣇ
㉸ఏᑟ㧗ศゎ⬟ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨

ࡑࡢ௚≉Ṧ

ᐃ

㟁Ꮚࢫࣆࣥඹ㬆⿦⨨ 㸦ESR㸧ᛂ┦ㄯ
ᐃ 1 ᳨యᇶᮏࡑࡢ௚≉Ṧ

10,000ᐃᛂ┦ㄯ

1 ᳨య(5 ඖ⣲ࡲ࡛)

20,0001 ඖ⣲㏣ຍࡈ࡜

4,000

⺯ග X ⥺ศᯒ⿦⨨ 㸦XRF㸧

1 ᳨య

21,000᭷ᶵᚤ㔞ඖ⣲ศᯒ⿦⨨ 㸦OEA㸧

1 ᳨య㉸㧗㏿ᗘ⌧㇟ゎᯒࢩࢫࢸ࣒

1 ᳨య

21,0000,000
31,000ᇶᮏ

ᐃ1௳

21,000㏱㐣ᆺศගィ

ᇶᮏ

ᐃ1௳

21,000㢧ᚤ࣭཯ᑕᆺศගィᇶᮏ

ᐃ1௳

21,00024 ᫬㛫ࡈ࡜

33,000ㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ⿦⨨ 㸦ICP㸧⣸እྍどศගගᗘィࣇ࣮࢚ࣜኚ᥮㉥እศගගᗘィࣉ࣮ࣟࣈᘧศගィ
᪕ගᗘィ

ᇶᮏ

ᐃ1௳

19,000෇஧Ⰽᛶศᩓィᇶᮏ

ᐃ1௳

21,000

⺯ගᑑ࿨

ᇶᮏ

ᐃ1௳

21,000ᇶᮏ

ᐃ1௳

21,000ศග⺯ගගᗘィᇶᮏ

ᐃ1௳

21,000㢧ᚤ࣮ࣞࢨ࣮࣐ࣛࣥศගィ

ᇶᮏ

ᐃ1௳

21,0001 ᳨య

21,000ᐃ⿦⨨ 㸦Tau㸧⤯ᑐ PL 㔞Ꮚ཰⋡ᐃ⿦⨨ 㸦QY㸧

⇕ศᯒ⿦⨨



ᇶᮏ

ᐃ1௳

20,000ᇶᮏ

ᐃ1௳

20,000࣓࣮ࣞ࢜ࢱ࣮

ᇶᮏ

ᐃ1௳

14,000

ືⓗ⢓ᙎᛶ

ᇶᮏ

ᐃ1௳

14,0001 ᳨య

41,000ࣇ࣮ࣟᘧ⢏Ꮚീศᯒ⿦⨨⢏Ꮚᚄ࣭ࢮ࣮ࢱ㟁఩࣭ศᏊ㔞

ᐃ⿦⨨

ᐃ⿦⨨

X ⥺࣐࢖ࢡࣟ CT ࢫ࢟ࣕࢼ࣮
࠙་Ꮫᆅ༊ࠚ
ᶵ

ჾ

ྡ

ᩘ

㔞

ᩱ

㔠 㸦෇㸧

᰾☢Ẽඹ㬆⿦⨨ 㸦AVANCE III 800 ᆺ㸧
H- NMR1 ᳨య

53,000C-NMR/2D NMR

1 ᳨య

77,000

3D NMR1 ᳨య

204,000

H- NMR1 ᳨య

32,000C-NMR/2D NMR

1 ᳨య

46,000

3D NMR1 ᳨య

135,000ᐃ 1 ᳨య

10,000᰾☢Ẽඹ㬆⿦⨨ 㸦AVANCE III 600 ᆺ㸧㟁Ꮚࢫࣆࣥඹ㬆⿦⨨ 㸦ESR㸧

ᇶᮏ

ࡑࡢ௚≉Ṧ
(ὀ 1)
(ὀ 2)

ᾘ㈝⛯ࡣᩱ㔠࡟ࡣྵࡲࢀ࡚࠾ࡽࡎ㸪ู㏵ㄳồࡍࡿࠋ

ᐃ

ᛂ┦ㄯ
ㄯ

๓ฎ⌮࣭ᾘ⪖ရ➼ࡀᚲせ࡞ሙྜ࡟ࡘ࠸࡚ࡣ㸪ู㏵┦ㄯࡢୖ㸪☜ᐃࡍࡿࠋ







4. ཷクヨ㦂➼䛾ᡭ⥆䛝(1) ཷクヨ㦂➼ࡢࡈ┦ㄯཷクヨ㦂ࡸศᯒࡢࡈ┦ㄯࡀ࠶ࡾࡲࡋࡓࡽࠊ㟁ヰ➼࡟࡚ࡈ㐃⤡ࡃࡔࡉ࠸ࠋᶵჾศᯒศ㔝ࡢ⫋ဨࡀ㐺ษ࡞ᶵჾᢸᙜ⪅ࢆࡈ⤂௓࠸ࡓࡋࡲࡍࠋ
(2) ᡴྜࡏ᪥ࡢỴᐃᢸᙜ⫋ဨ࡜ヨ㦂࡟ࡘ࠸࡚ᡴྜࡏࢆ⾜࠺᪥⛬ࢆㄪᩚࡋ࡚ࡃࡔࡉ࠸ࠋ
(3) ヨ㦂ᡴྜࡏᶵჾศᯒศ㔝࡟࠾㉺ࡋ࠸ࡓࡔࡁࠊᢸᙜࡢ⫋ဨ࡜ヨ㦂ෆᐜࠊᐇ᪋᪥➼ࡢᡴྜࡏࢆ⾜࡞࠸ࡲࡍࠋ
ࡑࡢ᫬࡟ヨ㦂ࢧࣥࣉࣝࡸヨ㦂࡟㛵ࡍࡿ㈨ᩱࡀࡈࡊ࠸ࡲࡋࡓࡽࠊ୍⥴࡟࠾ᣢࡕࡃࡔࡉ࠸ࠋ ࡞࠾ࠊヨ㦂ࡢෆᐜࡸヨ㦂ࢧࣥࣉࣝࡢᙧ≧࡟ࡼࡗ࡚ࡣࠊヨ㦂ࡀ⾜࡞࠼࡞࠸ሙྜࡶ࠶ࡾࡲࡍࠋ
(4) ཷクヨ㦂ࡢ࠾⏦ࡋ㎸ࡳཷクヨ㦂ࢆ⏦ࡋ㎸ࡲࢀࡿ᫬ࡣࠊ౫㢗᭩࡟ࡈグධ࠸ࡓࡔࡁࠊ฼⏝ᩱ㔠ࢆ࠾ᨭᡶ࠸ࡓࡔࡁࡲࡍࠋ
(5) ヨ㦂➼ࡢᐇ᪋
ヨ㦂➼ᐇ᪋᪥࡟ࡣ㸪ヨ㦂ࢧࣥࣉࣝࢆ࠾ᣢࡕ㎸ࡳ࠸ࡓࡔࡁ ᐃ࡟ྠᖍࡋ࡚ࡃࡔࡉ࠸ࠋ
(6) ࢹ࣮ࢱࡢཷ㡿ྠᖍࡋ࡚࠸ࡓࡔࡁ࡞ࡀࡽᚓࡽࢀࡓࢹ࣮ࢱࢆᇶ࡟ᢸᙜࡢᩍ⫋ဨ࡜ෆᐜ࡟ࡘ࠸࡚༠㆟ࡋࠊࢹ࣮ࢱ
ࢆ࠾ᣢࡕᖐࡾୗࡉ࠸ࠋู⣬ᵝᘧ➨㸯ྕ
ศ㔝㛗

ࢭࣥࢱ࣮㛗

ᶵჾศᯒศ㔝

◊✲┤㎄ᣐⅬㄢ㛗⿵బᣐⅬᨭ᥼ࢢ࣮ࣝࣉ

ͤ஦ົᢸᙜ⪅☜ㄆ⏝ཷ௜␒ྕྕᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝 ཷクヨ㦂➼౫㢗᭩
௧࿴

ᖺ

᭶

᪥

ᅜ❧኱Ꮫἲேᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗 Ẋఫᡤཪࡣᡤᅾᆅ
௻ᴗ➼ྡཬࡧ௦⾲⪅ྡ㸦㐃⤡ඛ㸧ᢸᙜ⪅㸦ᡤᒓ࣭Ặྡ㸧㟁ヰ␒ྕ
FAX ␒ྕ
㟁Ꮚ࣓࣮ࣝᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ཷクヨ㦂ࠊ ᐃཬࡧ᳨ᰝ➼ྲྀᢅせ㡯㸦௨ୗࠊࠕྲྀᢅせ㡯ࠖ
㸧ࡢෆᐜࢆ⇍▱ࡢୖࠊḟࡢ࡜࠾ࡾヨ㦂➼ࢆ౫㢗ࡋࡲࡍࠋရ౪ ヨ ≀ ရ ྡྡᩘ㔞ཬ ࡧ ᩘ 㔞౫ 㢗 ஦ 㡯㸦౑⏝ࡍࡿᶵჾྡ➼ࢆࡈグධୗࡉ࠸ࠋ㸧┦ ㄯ ᕼ ᮃ ᪥

௧࿴

ᖺ

᭶

᪥

ヨ㦂➼ᐇ᪋ᕼᮃ᪥

௧࿴

ᖺ

᭶
ࢭࣥࢱ࣮㛗

ୖグࡢෆᐜ࡟ࡘ࠸࡚ࠊྲྀᢅせ㡯➨㸱᮲୍㡯ࡢࡓࡔࡋ᭩ࡁ࡟ࡼࡿࠊྲྀᢅࢆㄆࡵࡿࠋ

ヨ㦂➼ᩱ㔠ྜィᩱ㔠ձู⾲ᩱ㔠⾲࡟ࡼࡿ

࠙౑⏝ᶵჾ㸦ヨ㦂➼✀ู㸧㸸ᩘ㔞㸦௳ᩘ㸧×༢౯㸻෇ࠚヨ㦂➼ࡢᩱ㔠ෆヂෆղ┦ㄯ➼࡟ࡼࡾタᐃヂࡋࡓ㸦ࡑࡢ௚≉Ṧ

࠙✚⟬➼ࠚ

ᐃ

෇

➼㸧ᩱ㔠ෆヂ
ヨ㦂➼ᢸᙜ⪅ͤὀ ኴ⥺ᯟෆࢆグධࡋ࡚ࡃࡔࡉ࠸ࠋྲྀᢅせ㡯ࡢෆᐜࢆཷࡅධࢀࡽࢀ࡞࠸ሙྜࠊ౫㢗ᐃࡣ⾜ࢃࢀࡲࡏࢇࠋ

᪥ู⣬ᵝᘧ➨ 2 ྕ
䝉䞁䝍䞊㛗

ศ㔝㛗

ᶵჾศᯒศ㔝

◊✲┤㎄ᣐⅬㄢ㛗⿵బᣐⅬᨭ᥼䜾䝹䞊䝥

䈜஦ົᢸᙜ⪅☜ㄆ⏝ᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ศᯒᶵჾ➼౑⏝⏦ㄳ᭩
௧࿴

ᖺ

᭶

᪥

ᅜ❧኱Ꮫἲேᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗Ẋᡤᒓᶵ㛵㸦఍♫㸧ఫᡤᡤᒓᶵ㛵㸦఍♫㸧ྡ
౑⏝⪅Ặྡ
ᡤᒓ㒊⨫
㟁ヰ␒ྕ

ୗグࡢ☜ㄆ᮲㡯࡟ྠពࡋ㸪ศᯒᶵჾ➼ࡢ౑⏝࡟ࡘ࠸࡚⏦ㄳࡋࡲࡍࠋ㸯 ศᯒᶵჾ౑⏝࣭ ᐃ࡟ࡘ࠸࡚ࡣࠊ⏦㎸᫬࡟౑⏝⪅ࡀᒱ㜧኱Ꮫࡢᢸᙜ⪅࡜༑ศ࡞┦ㄯࢆࡋ࡚ࠊࠕᮾᾏᅜ
❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ཷクヨ㦂➼౫㢗᭩ࠖࢆᥦฟࡍࡿࠋ㸰 ౑⏝࣭ ᐃࡢᩱ㔠ࡣ౑⏝๓࡟⣡ධࡍࡿࡶࡢ࡜ࡍࡿࠋ౑⏝࣭ ᐃࢆ୰Ṇࡋࡓሙྜ࡟࠾࠸࡚ࡶᩱ㔠ࡣ౑⏝⪅࡟㏉㑏ࡋ࡞࠸ࠋ㸱 ศᯒ⿦⨨ࡢᨾ㞀࡞࡝࡛ ᐃ࡛ࡁ࡞ࡃ࡞ࡗࡓሙྜ࡟ࡣࠊ ᐃࢆᘏᮇࡍࡿࡇ࡜ࡀ࠶ࡿࡀࠊࡑࢀ࡟㛵ࢃࡿᦆᐖࢆ౑⏝⪅ࡣㄳồ࡛ࡁ࡞࠸ࠋ㸲 ࢭࣥࢱ࣮㛗ཬࡧᢸᙜ⪅ࡣࠊ౑⏝⪅ࡀᶵჾࢆྲྀࡾᢅ࠺ࡢ࡟༑ศ࡞㈨㉁ࢆ᭷ࡋ࡚࠸࡞࠸࡜ุ᩿ࡋࡓ࡜ࡁ
࡟ࡣࠊ࠸࠿࡞ࡿ᫬Ⅼ࡟࠾࠸࡚ࡶసᴗࢆไṆ࡛ࡁࡿࠋࡲࡓࠊẘ≀ࡸἲᚊ➼࡟ゐࢀࡿࡶࡢࠊࡉࡽ࡟ࠊᶵ
ჾࢆ◚ᦆࡍࡿᜍࢀࡢ࠶ࡿࡶࡢ࡞࡝ࢭࣥࢱ࣮㛗ཬࡧᢸᙜ⪅ࡀཷධࢀ࡛ࡁ࡞࠸࡜ุ᩿ࡋࡓࡶࡢ࡟ࡘ࠸࡚ࡣࠊ ᐃࢆᣄྰࡍࡿࠋ㸳 ౑⏝࣭ ᐃ࡟ࡘ࠸࡚ࡣࠊ౑⏝⪅ࡣ༢⊂࡛ࡍࡿࡢ࡛ࡣ࡞ࡃࠊᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࡢᢸᙜ⪅ࡀྠᖍࡋ࡚ࠊᢸᙜ⪅ࡢᣦᑟ࣭❧఍࠸ࡢୗ࡛౑⏝⪅ࡀసᴗࡍࡿࠋ౑⏝⪅ࡢ㈐௵࡛ᶵჾࢆᲠᦆࡲࡓࡣ⁛ኻࡋࡓ࡜ࡁ࡟ࡣࠊ౑⏝⪅ࡀࡇࢀࢆཎᙧ࡟᚟ࡋࠊࡲࡓᦆᐖࢆ㈺ൾࡍࡿࠋ㸴 ౑⏝⪅ࡣࠊᶵჾࡢ฼⏝࡟ᙜࡓࡗ࡚ࠊ㛵ಀἲᚊࢆᏲࡾࠊᏳ඲⾨⏕ᑐ⟇ࠊ஦ᨾ㜵Ṇ࡟༑ศὀពࢆᡶ࠺ࡶ
ࡢ࡜ࡍࡿࠋࡲࡓࠊ౑⏝⪅ࡣࠊᣦᐃࡉࢀࡓሙᡤ௨እ࡟チྍ࡞ࡃฟධࡾࡍࡿࡇ࡜ࡣ࡛ࡁ࡞࠸ࠋ㸵 ๓グ 6 ࡢ㡯┠࡟཯ࡋ࡚ࠊ౑⏝⪅ࡢ㐣ኻ࡟ࡼࡾᮏேࡀ᛹ᡃࡲࡓࡣ⑓Ẽࢆࡋࡓሙྜࡣࠊᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࡣ୍ษ㈐௵ࢆ㈇ࢃ࡞࠸ࡶࡢ࡜ࡍࡿࠋ㸶 ౑⏝⪅ࡣࠊᢎㄆࡉࢀࡓ᫬㛫ෆ࡟Ύᤲࢆྵࡵ࡚ࡍ࡭࡚ࡢసᴗࢆ⤊஢ࡍࡿࠋ㸷ᐃ࡛ᚓࡽࢀࡓࢹ࣮ࢱࡣࠊᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࡀಖ㞀ࡍࡿࡶࡢ࡛ࡣ࡞࠸ࠋࡑࡢࡓࡵࠊࢹ࣮ࢱ
ࡢእ㒊࡬ࡢබ⾲࡟࠾࠸࡚ࠊ࠸࠿࡞ࡿሙྜ࡟࠾࠸࡚ࡶᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫྡࢆ౑࠺ࡇ࡜ࡣ࡛ࡁ
࡞࠸ࠋࡲࡓࠊࡑࡢ㝿࡟ᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࢆ≉ᐃ࡛ࡁࡿ⾲⌧ࡶ౑࠼࡞࠸ࠋࡓࡔࡋࠊࢭࣥࢱ࣮
㛗ࡀ኱Ꮫྡࡢ౑⏝ࢆチྍࡋࡓሙྜ࡟ࡣࡇࡢ㝈ࡾ࡛ࡣ࡞࠸ࠋ
10 ๓グ 9 ࡢ㡯┠࡟཯ࡋ࡚ࠊእ㒊࡟බ⾲ࡋࡓࡇ࡜࡛ᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࡀཷࡅࡓ⿕ᐖཬࡧᦆᐖ࡟
ࡘ࠸࡚ࡣࠊ౑⏝⪅ཬࡧࡑࡢ఍♫ࡀ㈺ൾࡍࡿࡶࡢ࡜ࡍࡿࠋ



4

άືሗ࿌

1. 2021 ᖺᗘᶵჾࡢ฼⏝≧ἣ
⾲ 4-1-1. ࠙ᰗᡞᆅ༊ࠚⓏ㘓ேᩘࠊᘏ฼⏝ேᩘࠊᘏ᳨యᩘࠊᘏ౑⏝᫬㛫
1-1኱ᆺ㟁Ꮚ㢧ᚤ㙾㸦㏱㐣ᆺ JEM-2100
㡯

┠

ᩍ⫱

ᆅᇦ

་

᪥ᮏ㟁Ꮚ〇㸧
ᕤ

ᖹᡂ 22 ᖺ 2 ᭶ 26 ᪥

⣡ධᖺ᭶᪥

ᛂ⏕

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⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

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ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

1

0

0

50

0

0

0

3

0

2

0

56

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

140

0

0

0

0

0

0

0

140

ᘏ᳨యᩘ㸦௳㸧

0

0

0

363

0

0

0

0

0

0

0

363

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

595.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

595.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

1-2

኱ᆺ㟁Ꮚ㢧ᚤ㙾㸦㏱㐣ᆺ H-7000
㡯

┠

ᩍ⫱

ᆅᇦ

᪥❧〇సᡤ〇㸧་ᕤᖹᡂ 21 ᖺ 5 ᭶ 12 ᪥

⣡ධᖺ᭶᪥

ᛂ⏕

ὶᇦ

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

10

39

5

0

0

0

0

0

35

89

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

10

3

0

0

0

0

0

9

22

ᘏ᳨యᩘ㸦௳㸧

0

0

0

19

4

0

0

0

0

0

24

47

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

29.5

12.0

0.0

0.0

0.0

0.0

0.0

56.5

98.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

1-3

㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾㸦S-4300 ᆺ
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┠

ᩍ⫱

ᆅᇦ

᪥❧ࣁ࢖ࢸࢡࣀࣟࢪ㸫ࢬ〇㸧

་

ᕤ

ᛂ⏕

ὶᇦ

ᖹᡂ 15 ᖺ 3 ᭶ 5 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

8

0

0

239

13

1

0

5

0

9

11

286

ᘏ฼⏝ேᩘ㸦ே㸧

1

0

0

372

40

0

0

0

0

3

1

417

ᘏ᳨యᩘ㸦௳㸧

1

0

0

1195

95

0

0

0

0

10

1

1,302

ᘏ౑⏝᫬㛫㸦㹆㸧

1.0

0.0

0.0

1239.5

85.0

0.0

0.0

0.0

0.0

15.0

2.0

1,342.5

⛉ᇶࢭ

⢾㙐ࢥ࢔

1-4

㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾㸦S-4800 ᆺ
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┠

ᩍ⫱

ᆅᇦ

᪥❧ࣁ࢖ࢸࢡࣀࣟࢪ㸫ࢬ〇㸧

་

ᕤ

ᛂ⏕

ὶᇦ

ᖹᡂ 20 ᖺ 3 ᭶ 27 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

1

0

10

226

11

0

0

5

0

7

11

271

ᘏ฼⏝ேᩘ㸦ே㸧

1

0

51

651

4

0

24

1

0

83

0

815

ᘏ᳨యᩘ㸦௳㸧

1

0

152

2534

23

0

97

3

0

332

0

3,142

ᘏ౑⏝᫬㛫㸦㹆㸧

3.0

0.0

169.5

2382.5

11.5

0.0

70.5

2.5

0.0

202.0

0.0

2,841.5

⛉ᇶࢭ

⢾㙐ࢥ࢔

1-5

㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾㸦S-3000N ᆺ
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┠

ᩍ⫱

ᆅᇦ

᪥❧ࣁ࢖ࢸࢡࣀࣟࢪ㸫ࢬ〇㸧

་

ᕤ

ᛂ⏕

ὶᇦ

ᖹᡂ 16 ᖺ 3 ᭶ 2 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

1

0

0

135

6

0

0

3

0

0

0

145

ᘏ฼⏝ேᩘ㸦ே㸧

3

0

0

17

4

0

0

0

0

0

0

24

ᘏ᳨యᩘ㸦௳㸧

9

0

0

59

15

0

0

0

0

0

0

83

ᘏ౑⏝᫬㛫㸦㹆㸧

9.5

0.0

0.0

89.0

11.0

0.0

0.0

0.0

0.0

0.0

0.0

109.5

1-6

ࢹࢪࢱ࣐ࣝ࢖ࢡࣟࢫࢥ࣮ࣉ 㸦DVM5000
㡯

┠

ᩍ⫱

ᆅᇦ

་

ࣛ࢖࢝〇㸧

ᕤ

ᛂ⏕

ᖹᡂ 22 ᖺ 11 ᭶ 10 ᪥

⣡ධᖺ᭶᪥
ὶᇦ

㐃๰

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

1

0

0

66

0

0

0

3

0

0

0

70

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

107

2

0

0

0

0

0

0

109

ᘏ᳨యᩘ㸦௳㸧

0

0

0

481

9

0

0

0

0

0

0

490

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

142.5

2.0

0.0

0.0

0.0

0.0

0.0

0.0

144.5



2

㉮ᰝᆺࣉ࣮ࣟࣈ㢧ᚤ㙾ࢩࢫࢸ࣒㸦AFM-5300, AFM5400

᪥❧ࣁ࢖ࢸࢡࢧ࢖࢚ࣥࢫ〇㸧

㡯

ὶᇦ

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ᛂ⏕

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ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

1

0

0

117

5

0

0

2

0

0

21

146

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

84

123

0

0

5

0

0

8

220

ᘏ᳨యᩘ㸦௳㸧

0

0

0

203

361

0

0

5

0

0

17

586

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

343.0

528.5

0.0

0.0

14.0

0.0

0.0

29.0

914.5

3

⣡ධᖺ᭶᪥ ᖹᡂ 26 ᖺ 3 ᭶ 27 ᪥࢔ࣝࣂࢵࢡ࣭ࣇ࢓࢖〇㸧 ⣡ධᖺ᭶᪥ ᖹᡂ 19 ᖺ 12 ᭶ 21 ᪥㉮ᰝᆺ X ⥺ග㟁Ꮚศගศᯒ⿦⨨㸦Quantera SXM-GS
㡯

┠

ᩍ⫱

ᆅᇦ

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ᕤ

ᛂ⏕

ὶᇦ

⛉ᇶࢭ

⢾㙐ࢥ࢔

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ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

162

0

0

0

0

0

2

8

172

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

274

0

0

0

0

0

0

0

274

ᘏ᳨యᩘ㸦௳㸧

0

0

0

981

0

0

0

0

0

0

0

981

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

3696.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

3,696.0

ὶᇦ

⛉ᇶࢭ

⢾㙐ࢥ࢔

4-1
㡯

㧗ศゎ⬟㉁㔞ศᯒ⿦⨨㸦JMS-700
┠

ᩍ⫱

ᆅᇦ

་

ᕤ

7

0

0

ᘏ฼⏝ேᩘ㸦ே㸧

440ᘏ᳨యᩘ㸦௳㸧3800ᘏ౑⏝᫬㛫㸦㹆㸧

28.5

0.0

Ⓩ㘓ேᩘ㸦ே㸧4-2

᪥ᮏ㟁Ꮚ〇㸧

┠

ᩍ⫱

ᆅᇦ

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ᒱ⸆

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40

19

0

5

0

0

0

0

71

0

58

0

0

1

0

0

0

0

103

0

435

0

0

1

0

0

0

0

816

0.0

112.5

0.0

0.0

1.0

0.0

0.0

0.0

0.0

142.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

ᅄ㔜ᴟᆺ㉁㔞ศᯒ⿦⨨㸦JMS-$0681*,.
㡯ᖹᡂ 16 ᖺ 1 ᭶ 19 ᪥

⣡ධᖺ᭶᪥

ᛂ⏕

་

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᪥ᮏ㟁Ꮚ〇㸧ᛂ⏕ὶᇦ

ᖹᡂ 16 ᖺ 1 ᭶ 19 ᪥

⣡ධᖺ᭶᪥
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ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

10

28

11

0

0

0

0

2

0

51

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

2

42

0

0

0

0

0

0

44

ᘏ᳨యᩘ㸦௳㸧

0

0

0

2

63

0

0

0

0

0

0

65

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

7.5

181.5

0.0

0.0

0.0

0.0

0.0

0.0

189.0

4-3

࢞ࢫࢡ࣐ࣟࢺࢢࣛࣇ㉁㔞ศᯒࢩࢫࢸ࣒㸦GC-mateϩ ᪥ᮏ㟁Ꮚ〇㸧
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┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ᛂ⏕

ὶᇦ

ᖹᡂ 16 ᖺ 3 ᭶ 31 ᪥⟶⌮᥮ᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

2

4

0

0

0

0

0

0

6

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ᳨యᩘ㸦௳㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

4-4

ᾮయࢡ࣐ࣟࢺࢢࣛࣇ㸦Agilent1100
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┠

ᩍ⫱

ᆅᇦ

་

࢔ࢪࣞࣥࢺ♫〇㸧ᕤᛂ⏕

ᖹᡂ 16 ᖺ 3 ᭶ 22 ᪥

⣡ධᖺ᭶᪥
ὶᇦ

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௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

5

0

10

0

17

0

5

0

0

0

0

37

ᘏ฼⏝ேᩘ㸦ே㸧

10

0

0

0

80

0

0

0

0

0

0

90

ᘏ᳨యᩘ㸦௳㸧

319

0

0

0

940

0

0

0

0

0

0

1,259

ᘏ౑⏝᫬㛫㸦㹆㸧

80.0

0.0

0.0

0.0

906.0

0.0

0.0

0.0

0.0

0.0

0.0

986.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

4-5

AccuTOF㸦LC-PLUS JMS-T100LP
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┠

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ᆅᇦ

་

᪥ᮏ㟁Ꮚ〇㸧
ᕤ

ᖹᡂ 23 ᖺ 6 ᭶ 29 ᪥

⣡ධᖺ᭶᪥

ᛂ⏕

ὶᇦ

㐃๰

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ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

3

0

0

65

47

0

5

3

2

0

0

125

ᘏ฼⏝ேᩘ㸦ே㸧

1

0

0

146

108

0

1

0

0

0

0

256

ᘏ᳨యᩘ㸦௳㸧

11

0

0

662

255

0

2

0

0

0

0

930

ᘏ౑⏝᫬㛫㸦㹆㸧

2.0

0.0

0.0

257.5

239.0

0.0

1.0

0.0

0.0

0.0

0.0

499.5



4-6

㣕⾜᫬㛫ᆺ㉁㔞ศᯒ⿦⨨㸦AXIMA-Resonance
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┠

ᩍ⫱

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⟶⌮᥮ᖺ᭶᪥ ᖹᡂ 26 ᖺ 9 ᭶ 1 ᪥

ᓥὠ〇㸧

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⢾㙐ࢥ࢔

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Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

52

47

0

5

3

0

0

0

107

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

62

194

0

7

0

0

0

0

263

ᘏ᳨యᩘ㸦௳㸧

0

0

0

203

1325

0

19

0

0

0

0

1,547

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

76.0

306.0

0.0

9.0

0.0

0.0

0.0

0.0

391.0

4-7 nanoLC 㸦LC-20ADnano ᓥὠ〇㸧
㡯

┠

ᩍ⫱

ᆅᇦ

་

⟶⌮᥮ᖺ᭶᪥ ᖹᡂ 26 ᖺ 9 ᭶ 1 ᪥
ᕤ

ᛂ⏕

ὶᇦ

㐃๰

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

3

0

0

5

0

0

0

0

8

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ᳨యᩘ㸦௳㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

5-1

ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦JNM-ECX400P ᆺ
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

᪥ᮏ㟁Ꮚ〇㸧

ᛂ⏕ὶᇦᖹᡂ 19 ᖺ 3 ᭶ 28 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

7

0

0

109

46

0

5

3

0

2

0

172

ᘏ฼⏝ேᩘ㸦ே㸧

250

0

0

995

428

0

35

0

0

0

0

1708

ᘏ᳨యᩘ㸦௳㸧

2105

0

0

1634

750

0

41

0

0

0

0

4,530

ᘏ౑⏝᫬㛫㸦㹆㸧

271.5

0.0

0.0

1018.0

430.0

0.0

19.0

0.0

0.0

0.0

0.0

1,738.5

⛉ᇶࢭ

⢾㙐ࢥ࢔

5-2

ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦JNM-ECA600 ᆺ
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

᪥ᮏ㟁Ꮚ〇㸧

ᛂ⏕ὶᇦᖹᡂ 19 ᖺ 3 ᭶ 28 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

10

0

0

104

44

0

5

3

0

2

0

168

ᘏ฼⏝ேᩘ㸦ே㸧

112

0

0

190

460

0

18

0

0

0

0

780

ᘏ᳨యᩘ㸦௳㸧

353

0

0

333

868

0

73

0

0

0

0

1,627

ᘏ౑⏝᫬㛫㸦㹆㸧

79.5

0.0

0.0

239.5

1583.0

0.0

79.0

0.0

0.0

0.0

0.0

1,981.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

5

3

5-4

ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦JNM-ESA500 ᆺ
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

᪥ᮏ㟁Ꮚ〇㸧

ᛂ⏕

44

㐃๰

௚

0

ᘏ฼⏝ேᩘ㸦ே㸧

140

0

0

707

292

0

0

0

0

0

0

1139

ᘏ᳨యᩘ㸦௳㸧

508

0

0

1839

568

0

0

0

0

0

0

2,915

ᘏ౑⏝᫬㛫㸦㹆㸧

107.5

0.0

0.0

415.5

360.5

0.0

0.0

0.0

0.0

0.0

0.0

883.5

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ᅛయ ᪥ᮏ㟁Ꮚ〇㸧

ᛂ⏕

ὶᇦ

0

ィ

0

ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦JNM-ESA500 ᆺ

0

ᒱ⸆

10

㡯

0

ᖹᡂ 16 ᖺ 2 ᭶ 27 ᪥⟶⌮᥮ᖺ᭶᪥

Ⓩ㘓ேᩘ㸦ே㸧

5-5

110

ὶᇦ

⢾㙐ࢥ࢔

㐃๰

172

ᖹᡂ 16 ᖺ 2 ᭶ 27 ᪥⟶⌮᥮ᖺ᭶᪥

⛉ᇶࢭ

0

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

7

2

0

0

0

0

2

0

11

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ᳨యᩘ㸦௳㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

6

㟁Ꮚࢫࣆࣥඹ㬆⿦⨨㸦JES-FA100
㡯

┠

ᩍ⫱

ᆅᇦ

᪥ᮏ㟁Ꮚ〇㸧་ᕤ

ᖹᡂ 16 ᖺ 2 ᭶ 27 ᪥⟶⌮᥮ᖺ᭶᪥
ᛂ⏕

ὶᇦ

㐃๰

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

97

3

0

0

0

0

0

0

100

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

24

0

0

0

0

0

0

0

24

ᘏ᳨యᩘ㸦௳㸧

0

0

0

54

0

0

0

0

0

0

0

54

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

119.5

0.0

0.0

0.0

0.0

0.0

0.0

0.0

119.5



7

ㄏᑟ⤖ྜࣉࣛࢬ࣐Ⓨගศᯒ⿦⨨㸦ULTIMA2
㡯

┠

ᩍ⫱

ᆅᇦ

་

⣡ධᖺ᭶᪥ ᖹᡂ 20 ᖺ 10 ᭶ 15 ᪥ᇼሙ〇సᡤ〇㸧

ᕤ

ᛂ⏕

ὶᇦ

㐃๰

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

8

0

0

28

23

0

0

3

0

5

12

79

ᘏ฼⏝ேᩘ㸦ே㸧

35

0

0

61

34

0

0

0

0

0

13

143

ᘏ᳨యᩘ㸦௳㸧

1286

0

0

2012

2299

0

0

0

0

0

216

5,813

ᘏ౑⏝᫬㛫㸦㹆㸧

250.0

0.0

0.0

288.0

258.5

0.0

0.0

0.0

0.0

0.0

100.5

897.0

8-1

Ἴ㛗ศᩓᆺ⺯ග X ⥺ศᯒ⿦⨨
㡯

┠

ᩍ⫱

ᆅᇦ

㸦S8 TIGER་ᕤᛂ⏕Ⓩ㘓ேᩘ㸦ே㸧100ᘏ฼⏝ேᩘ㸦ே㸧000ᘏ᳨యᩘ㸦௳㸧000ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

115.5

8-2

ࣅ࣮ࢻ࣐ࢩ࣮ࣥ
㡯┠

㸦.Dtanax-.

ᩍ⫱ᆅᇦࣈ࣮ࣝ࢝AXS ♫〇㸧

97

ὶᇦ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

0

0

0

0

0

7

0

79

1

0

0

0

0

0

0

80

218

1

0

0

0

0

0

0

219

2.0

0.0

0.0

0.0

0.0

0.0

0.0

117.5

ࣈ࣮ࣝ࢝AXS ♫〇㸧་ᖹᡂ 24 ᖺ 3 ᭶ 30 ᪥

⣡ධᖺ᭶᪥

⛉ᇶࢭ

ᕤ

ᛂ⏕

ᖹᡂ 24 ᖺ 3 ᭶ 30 ᪥

⣡ධᖺ᭶᪥
ὶᇦ

㐃๰

105

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

1

0

0

97

0

0

0

0

0

7

0

105

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ᳨యᩘ㸦௳㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

8-3
㡯

⢊○ᶵ

㸦MC-4A┠ᩍ⫱ࣈ࣮ࣝ࢝AXS ♫〇㸧ᆅᇦ་ᖹᡂ 24 ᖺ 3 ᭶ 30 ᪥

⣡ධᖺ᭶᪥

ᕤ

ᛂ⏕

ὶᇦ

㐃๰

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

1

0

0

97

0

0

0

0

0

7

0

105

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

2

0

0

0

0

0

0

0

2

ᘏ᳨యᩘ㸦௳㸧

0

0

0

160

0

0

0

0

0

0

0

160

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

384.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

384.0

9

᭷ᶵᚤ㔞ඖ⣲ศᯒ⿦⨨㸦CHN JM10
㡯

┠

ᩍ⫱

ᆅᇦ

་

ࢪ࢙࢖࣭ࢧ࢖࢚ࣥࢫ࣭ࣛ࣎〇㸧
ᕤ

ᛂ⏕

ὶᇦ

ᖹᡂ 23 ᖺ 8 ᭶ 4 ᪥

⣡ධᖺ᭶᪥

⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

12

0

0

56

2

0

5

0

0

0

0

75

ᘏ฼⏝ேᩘ㸦ே㸧

14

0

0

15

10

0

0

0

0

0

0

39

ᘏ᳨యᩘ㸦௳㸧

363

0

0

216

99

0

0

0

0

0

0

678

ᘏ౑⏝᫬㛫㸦㹆㸧

159.0

0.0

0.0

155.0

56.5

0.0

0.0

0.0

0.0

0.0

0.0

370.5

10

㉸㧗㏿ᗘ⌧㇟ゎᯒࢩࢫࢸ࣒㸦㈚ฟ㸧㉸㧗㏿ᗘᗘ᧜ᙳ⿦⨨㸪㧗㏿ᗘࣅࢹ࢜⿦⨨㸪ගቑᖜ⿦⨨㸪⇕⏬ീゎᯒ⿦⨨㸪ࣃࣝࢫࢪ࢙ࢿ࣮ࣞࢱ㸪࣮ࣞࢨ࣮↷᫂⿦⨨㸪
PIV ࢩࢫࢸ࣒

⣡ධᖺ᭶᪥ ᖹᡂ 11 ᖺ 3 ᭶ 19 ᪥ࣁ࢖ࣃ࣮ࣅࢪࣙࣥ㸪㧗㏿ᗘࣅࢹ࣓࢜࢝ࣛࢩࢫࢸ࣒㸪ࢧ࣮࣓ࣔ࢝ࣛ
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

Ⓩ㘓ேᩘ㸦ே㸧000ᘏ฼⏝ேᩘ㸦ே㸧00ᘏ᳨యᩘ㸦௳㸧00ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

ᛂ⏕

ὶᇦ

⣡ධᖺ᭶᪥

⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

ᖹᡂ 23 ᖺ 7 ᭶ 1 ᪥

௚

ᒱ⸆

ィ

47

1

0

0

0

0

0

0

0

30

0

0

0

0

0

0

0

30

0

6570

0

0

0

0

0

0

0

6,570

0.0

15768.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

15,768.0



48

11-1

⣸እྍどศගගᗘィ 㸦O950 UV/VIS/NIR

㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ࣃ࣮࢚࣐࣮࢟ࣥࣝ〇㸧ᛂ⏕ὶᇦᖹᡂ 23 ᖺ 4 ᭶ 6 ᪥

⣡ධᖺ᭶᪥

⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

2

0

0

126

12

0

5

3

0

2

0

150

ᘏ฼⏝ேᩘ㸦ே㸧

2

0

0

51

10

0

0

0

0

0

0

63

ᘏ᳨యᩘ㸦௳㸧

3

0

0

226

48

0

0

0

0

0

0

277

ᘏ౑⏝᫬㛫㸦㹆㸧

4.0

0.0

0.0

138.5

12.5

0.0

0.0

0.0

0.0

0.0

0.0

155.0

11-2

㸦Spectrum100 FT-IR ࣃ࣮࢚࣐࣮࢟ࣥࣝ♫〇㸧 ⣡ධᖺ᭶᪥ࣇ࣮࢚ࣜኚ᥮㉥እศගගᗘィ

㡯

┠

ᩍ⫱

ᆅᇦ

6

Ⓩ㘓ேᩘ㸦ே㸧

་

0

ᕤ

0

ᛂ⏕

132

ὶᇦ

⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

ᖹᡂ 23 ᖺ 3 ᭶ 22 ᪥

௚

ᒱ⸆

ィ

14

0

5

3

0

0

0

160

ᘏ฼⏝ேᩘ㸦ே㸧

1

0

0

32

2

0

0

4

0

0

0

39

ᘏ᳨యᩘ㸦௳㸧

14

0

0

141

13

0

0

4

0

0

0

172

ᘏ౑⏝᫬㛫㸦㹆㸧

1.5

0.0

0.0

45.0

5.0

0.0

0.0

75.0

0.0

0.0

0.0

126.5

⛉ᇶࢭ

⢾㙐ࢥ࢔

11-3

㢧ᚤ࣭཯ᑕᆺ㉥እศගගᗘィ㸦㢧ᚤ-IR 460PLUS

㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

4

0

0

ᘏ฼⏝ேᩘ㸦ே㸧

47

0ᘏ᳨యᩘ㸦௳㸧4050ᘏ౑⏝᫬㛫㸦㹆㸧

73.0

0.0

Ⓩ㘓ேᩘ㸦ே㸧

11-4

᪥ᮏศග〇㸧

ᛂ⏕ὶᇦ

ᖹᡂ 15 ᖺ 1 ᭶ 10 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

60

2

0

5

0

0

0

0

71

0

8

0

0

3

0

0

0

0

58

0

12

0

0

6

0

0

0

0

423

0.0

13.5

0.0

0.0

2.5

0.0

0.0

0.0

0.0

89.0

In Situ ࣇ࣮࢚ࣜኚ᥮㉥እศගගᗘィ㸦ReactIR 4100 F-GU 㺜㺻㺙㺎㺡㺖㺧㺹㺚㺼㺎♫〇㸧 ⣡ධᖺ᭶᪥ ᖹᡂ 16 ᖺ 3 ᭶ 24 ᪥

㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ᛂ⏕

ὶᇦ

㐃๰

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

0

2

0

0

0

0

0

0

2

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ᳨యᩘ㸦௳㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

11-5

᪕ගィ 㸦P-2300

㡯

┠

ᩍ⫱

᪥ᮏศග〇㸧
ᆅᇦ་

ᖹᡂ 23 ᖺ 3 ᭶ 1 ᪥

⣡ධᖺ᭶᪥
ᕤ

ᛂ⏕

ὶᇦ

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

11

19

0

5

0

0

0

0

35

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

16

23

0

1

0

0

0

0

40

ᘏ᳨యᩘ㸦௳㸧

0

0

0

53

67

0

3

0

0

0

0

123

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

22.5

59.0

0.0

1.0

0.0

0.0

0.0

0.0

82.5

ᕤ

ᛂ⏕

⛉ᇶࢭ

⢾㙐ࢥ࢔

0

3

11-6 FT_IR (FT-IR4700
㡯

┠

ᩍ⫱

⣡ධᖺ᭶᪥ ᖹᡂ 31 ᖺ 10 ᭶ 1 ᪥᪥ᮏศග〇)

ᆅᇦ་

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

28

ᘏ฼⏝ேᩘ㸦ே㸧000ᘏ᳨యᩘ㸦௳㸧000ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

12

෇஧Ⰽᛶศᩓィ㸦CD J-820P
㡯

┠

ᩍ⫱

ᆅᇦ

ὶᇦ

௚

15

52

11

0

0

0

0

0

78

61

2096

0

0

0

0

0

0

2,157

34.5

152.5

36.0

0.0

0.0

0.0

0.0

0.0

223.0

ᛂ⏕

ὶᇦ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

0

0

6

30

ᘏ฼⏝ேᩘ㸦ே㸧000ᘏ᳨యᩘ㸦௳㸧000ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

0

ィ

1

ᕤ

0

ᒱ⸆

20

᪥ᮏศග〇㸧
་㐃๰

52

ᖹᡂ 14 ᖺ 3 ᭶ 18 ᪥

⣡ධᖺ᭶᪥
㐃๰

0

௚

ᒱ⸆

43

0

0

3

0

0

23

22

0

0

0

0

0

16

61

64

113

0

0

0

0

0

80

257

164.5

95.5

0.0

0.0

0.0

0.0

0.0

67.0

327.0



11

ィ

93

13-1

⺯ගᑑ࿨

㡯

┠

ᐃ⿦⨨㸦Quantaurus-Tau὾ᯇ࣍ࢺࢽࢡࢫ〇㸧

ᩍ⫱

ᕤ

ᆅᇦ

་

ᛂ⏕

ᖹᡂ 23 ᖺ 8 ᭶ 26 ᪥

⣡ධᖺ᭶᪥

ὶᇦ

⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

74

0

0

0

0

0

0

5

79

ᘏ฼⏝ேᩘ㸦ே㸧

2

0

0

59

0

0

2

0

0

0

0

63

ᘏ᳨యᩘ㸦௳㸧

3

0

0

193

0

0

2

0

0

0

0

198

ᘏ౑⏝᫬㛫㸦㹆㸧

4.0

0.0

0.0

155.0

0.0

0.0

8.0

0.0

0.0

0.0

0.0

167.0

13-2

⤯ᑐ PL 㔞Ꮚ཰⋡

㡯

┠

ᩍ⫱

ᐃ⿦⨨

㸦Quantaurus-QY

ᆅᇦ

་

ᕤ

Ⓩ㘓ேᩘ㸦ே㸧000ᘏ฼⏝ேᩘ㸦ே㸧

10ᘏ᳨యᩘ㸦௳㸧20ᘏ౑⏝᫬㛫㸦㹆㸧

0.5

0.0

13-3

ศග⺯ගගᗘィ㡯┠ᩍ⫱

㸦FP-8600
ᆅᇦ

὾ᯇ࣍ࢺࢽࢡࢫ〇㸧ᛂ⏕ὶᇦᖹᡂ 23 ᖺ 8 ᭶ 26 ᪥

⣡ධᖺ᭶᪥

⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

74

0

0

0

0

0

0

5

0

66

0

0

1

0

0

0

1

69

0

230

0

0

0

0

0

0

1

233

0.0

159.0

0.0

0.0

0.5

0.0

0.0

0.0

3.0

163.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

᪥ᮏศග〇㸧
་

ᖹᡂ 23 ᖺ 8 ᭶ 2 ᪥

⣡ධᖺ᭶᪥

ᕤ

ᛂ⏕

ὶᇦ

㐃๰

79

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

69

0

0

5

3

0

0

0

77

ᘏ฼⏝ேᩘ㸦ே㸧

2

0

0

168

0

0

1

0

0

0

0

171

ᘏ᳨యᩘ㸦௳㸧

3

0

0

642

0

0

1

0

0

0

0

646

ᘏ౑⏝᫬㛫㸦㹆㸧

4.0

0.0

0.0

272.0

0.0

0.0

2.5

0.0

0.0

0.0

0.0

278.5

14-1
㡯

ࣇ࢙࣒ࢺ⛊ࣇ࢓࢖ࣂ࣮࣮ࣞࢨ࣮㸦BS-60-YS

࢔࢖ࢩࣥ⢭ᶵ〇㸧

┠

ᛂ⏕

ᩍ⫱

ᆅᇦ

་

ᕤ

ὶᇦ

ᖹᡂ 18 ᖺ 3 ᭶ 3 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

⛉ᇶࢭ

⢾㙐ࢥ࢔

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ᳨యᩘ㸦௳㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

14-2

ࢸࣛ࣊ࣝࢶศග㉮ᰝᆺ㢧ᚤ㙾 㸦THz-TDS

㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

࢜ࢨ࣡⛉Ꮫ〇㸧ᛂ⏕ὶᇦᖹᡂ 18 ᖺ 3 ᭶ 3 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

2

0

0

0

0

0

0

0

2

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ᳨యᩘ㸦௳㸧

0

0

0

0

0

0

0

0

0

0

0

0

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

15

㢧ᚤ࣮ࣞࢨ࣮࣐ࣛࣥศගࢩࢫࢸ࣒㸦NRS-1000
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

᪥ᮏศග〇㸧
ᛂ⏕ὶᇦ

ᖹᡂ 15 ᖺ 3 ᭶ 25 ᪥

⣡ධᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

110

0

0

0

0

0

0

0

110

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

97

0

0

1

0

0

0

0

98

ᘏ᳨యᩘ㸦௳㸧

0

0

0

280

0

0

2

0

0

0

0

282

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

185.5

0.0

0.0

1.5

0.0

0.0

0.0

0.0

187.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

0

0

16

⇕ศᯒࢩࢫࢸ࣒㸦EXSTAR-6000
㡯┠Ⓩ㘓ேᩘ㸦ே㸧ᩍ⫱ᆅᇦ3࢚ࢫ࢔࢖࢔࢖〇㸧

་

0

ᕤ

0

80

ᖹᡂ 16 ᖺ 3 ᭶ 19 ᪥

⣡ධᖺ᭶᪥

ᛂ⏕

ὶᇦ

15

0

㐃๰

௚

0

ᒱ⸆

7

ィ

5

110

ᘏ฼⏝ேᩘ㸦ே㸧

4

0

0

143

87

0

0

0

0

0

3

237

ᘏ᳨యᩘ㸦௳㸧

27

0

0

221

224

0

0

0

0

0

7

479

ᘏ౑⏝᫬㛫㸦㹆㸧

18.5

0.0

0.0

965.5

444.0

0.0

0.0

0.0

0.0

0.0

18.5

1,446.5



17-1

ࣇ࣮ࣟᘧ⢏Ꮚീศᯒ⿦⨨ 㸦FPIA ࣐ࣝࣂ࣮ࣥ♫〇㸧

㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ᛂ⏕

ᖹᡂ 22 ᖺ 9 ᭶ 30 ᪥

⣡ධᖺ᭶᪥
ὶᇦ

⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

23

2

0

0

0

0

2

0

27

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

8

102

0

0

0

0

0

0

110

ᘏ᳨యᩘ㸦௳㸧

0

0

0

35

923

0

0

0

0

0

0

958

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

28.5

321.5

0.0

0.0

0.0

0.0

0.0

0.0

350.0

17-2

ᐃ⿦⨨ 㸦Zetasizer Nano ZS⢏Ꮚᚄ࣭ࢮ࣮ࢱ㟁఩࣭ศᏊ㔞

㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ὶᇦ

28

0

ᖹᡂ 22 ᖺ 9 ᭶ 30 ᪥࣐ࣝࣂ࣮ࣥ♫〇㸧 ⣡ධᖺ᭶᪥
⛉ᇶࢭ

⢾㙐ࢥ࢔

0

0

㐃๰

௚

0

0

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

45

46

0

0

0

0

ᘏ᳨యᩘ㸦௳㸧

0

0

0

144

267

0

0

0

0

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

158.0

105.5

0.0

0.0

0.0

0.0

0.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

0

0

0

6

0

࣓࣮ࣞ࢜ࢱ࣮ 㸦AR-*.G TA࣭࢖ࣥࢫࢶ࣓ࣝࣥࢺ♫〇㸧
┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ᛂ⏕

53

144

189

600

158.5

422.0

௚

ᒱ⸆

ィ

0

0

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

45

134

0

0

0

0

0

0

179

ᘏ᳨యᩘ㸦௳㸧

0

0

0

153

872

0

0

0

0

0

0

1,025

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

132.5

523.5

0.0

0.0

0.0

0.0

0.0

0.0

656.0

ᐃ⿦⨨ 㸦'0$4.G TA࣭࢖ࣥࢫࢶ࣓ࣝࣥࢺ♫〇㸧

ືⓗ⢓ᙎᛶ
┠

0

0
0

0

㡯

7

111

ᖹᡂ 23 ᖺ 3 ᭶ 31 ᪥

⣡ධᖺ᭶᪥
㐃๰

21

Ⓩ㘓ேᩘ㸦ே㸧

18-2

62

ὶᇦ

2

ィ

0

㡯

0

ᒱ⸆

Ⓩ㘓ேᩘ㸦ே㸧

18-1

60

ᛂ⏕

ᩍ⫱

ᆅᇦ

་

ᕤ

ᛂ⏕

ὶᇦ

⛉ᇶࢭ

ᖹᡂ 23 ᖺ 3 ᭶ 31 ᪥

⣡ධᖺ᭶᪥

⢾㙐ࢥ࢔

㐃๰

75

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

62

7

0

0

0

0

6

0

75

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

41

3

0

0

0

0

9

0

53

ᘏ᳨యᩘ㸦௳㸧

0

0

0

108

12

0

0

0

0

40

0

160

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

286.0

14.0

0.0

0.0

0.0

0.0

96.0

0.0

396.0

19

X ⥺࣐࢖ࢡࣟ CT ࢫ࢟ࣕࢼ࣮ 㸦S.<6&$1-GU ᮾ㝧ࢸࢡࢽ࢝〇㸧
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ᛂ⏕

ὶᇦ

ᖹᡂ 22 ᖺ 11 ᭶ 5 ᪥

⣡ධᖺ᭶᪥

⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

1

0

5

59

22

0

0

5

0

6

2

100

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

0

122

416

0

0

3

0

24

0

565

ᘏ᳨యᩘ㸦௳㸧

0

0

0

118

1409

0

0

3

0

72

0

1,602

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

0.0

519.0

1812.0

0.0

0.0

7.0

0.0

218.5

0.0

2,556.5* ࢹ࣮ࢱฎ⌮ࡢࡳࡢ฼⏝⪅ࡶྵࡴト㸧ᩍ⫱㸸ᩍ⫱Ꮫ㒊㸪ᆅᇦ㸸ᆅᇦ⛉Ꮫ㒊㸪་㸸་Ꮫ㒊㸪ᕤ㸸ᕤᏛ㒊㸪ᛂ⏕㸸ᛂ⏝⏕≀⛉Ꮫ㒊㸪ὶᇦ㸸ὶᇦᅪ⛉Ꮫ◊✲ࢭࣥࢱ࣮㸪⛉ᇶࢭ㸸⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㸪⢾㙐ࢥ࢔㸸⢾㙐⏕࿨ࢥ࢔◊✲ᡤ 㐃๰㸸㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉㸪௚㸸㐃ྜ㎰Ꮫ◊✲⛉࣭㧗➼◊✲㝔(⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㝖ࡃ)࣭ྡྂᒇ኱Ꮫ⾲ 4-1-2. ࠙་Ꮫᆅ༊ࠚⓏ㘓ேᩘࠊᘏ฼⏝ேᩘࠊᘏ᳨యᩘࠊᘏ౑⏝᫬㛫
1-1ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦Bruker Biospin AVANCEϪ 600
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ᛂ⏕

ὶᇦ

ᖹᡂ 23 ᖺ 4 ᭶ 1 ᪥ࣈ࣮ࣝ࢝〇㸧 ⟶⌮᥮ᖺ᭶᪥
⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

5

0

41

0

5

3

2

0

37

93

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

1

0

80

0

41

0

0

0

0

122

ᘏ᳨యᩘ㸦௳㸧

0

0

1

0

84

0

34

0

0

0

0

119

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

9.0

0.0

809.0

0.0

604.5

0.0

0.0

0.0

0.0

1,422.5

1-2ࣇ࣮࢚ࣜኚ᥮᰾☢Ẽඹ㬆⿦⨨㸦Bruker Biospin AVANCEϪ 800
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ᛂ⏕

ὶᇦ

ᖹᡂ 23 ᖺ 4 ᭶ 1 ᪥ࣈ࣮ࣝ࢝〇㸧 ⟶⌮᥮ᖺ᭶᪥
⛉ᇶࢭ

⢾㙐ࢥ࢔

㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

5

0

40

0

5

10

2

0

21

83

ᘏ฼⏝ேᩘ㸦ே㸧

0

0

36

1

48

0

26

34

0

0

22

167

ᘏ᳨యᩘ㸦௳㸧

0

0

173

1

104

0

65

48

0

0

35

426

ᘏ౑⏝᫬㛫㸦㹆㸧

0.0

0.0

243.0

1.5

472.0

0.0

407.0

384.5

0.0

0.0

38.0

1,546.0

⛉ᇶࢭ

⢾㙐ࢥ࢔

2

㉸㧗㍤ᗘ X ⥺ᅇᢡ⿦⨨ 㸦Rigaku FR-E SuperBright
㡯

┠

ᩍ⫱

ᆅᇦ

་

ᕤ

ࣜ࢞ࢡ〇)

ᛂ⏕

ὶᇦ

ᖹᡂ 23 ᖺ 4 ᭶ 1 ᪥⟶⌮᥮ᖺ᭶᪥
㐃๰

௚

ᒱ⸆

ィ

Ⓩ㘓ேᩘ㸦ே㸧

0

0

0

8

12

3

0

3

0

0

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1. N. Oka.6X]XNL$0RUL.$QGR, Stereoselective synthesis of 1,2-cis-glycosyl sulfones and theirapplication in one-pot Julia olefination for the synthesis of exo-glycals, Eur. J. Org. Chem., 2021, 59225933 (2021)䠖(MS, NMR)
2. N. Oka + +LUDED\DVKL . .XPDGD . $QGR, Synthesis of xanthosine 2-phosphate diesters via
phosphitylation of the carbonyl group, Bioorg. Med. Chem. Lett., 54, 128439 (2021)䠖(MS, NMR)
3. N. Oka0.DQGD0)XUX]DZD:$UDL.$QGR, Serendipitous one-step synthesis of cyclopentene
derivatives from 5ƍ-deoxy-5ƍ-heteroarylsulfonylnucleosides as nucleoside-derived Julia-.RFLHQVNL
reagents, J. Org. Chem., 86, 16684 (2021)䠖(MS, NMR)
4. . $QGR, H. Watanabe, X. Zhu, One-pot preparation of (E)-DE-unsaturated aldehydes by a Julia.RFLHQVNL reaction of 2,2-dimethoxyethy PT sulfone followed by acid hydrolysis, J. Org. Chem., 86,
6969-6973 (2021)䠖(MS, NMR)
5. S.W. Hyun, A. Imamura, H. Ishida.+3LHSHQEULQN6(*ROGEOXP(3/LOOHKRM, The sialidase NEU1
directly interacts with the juxta membranous segment of the cytoplasmic domain of mucin-1 to inhibit
GRZQVWUHDP3,.-Akt signaling, J. Biol. Chem., 297, 101337 (2021)䠖(NMR)
6. M. Sai, Potassium base-promoted diastereoselective synthesis of 1,3-diols from allylic alcohols andaldehydes through a tandem allylic-isomerization/aldol–tishchenko reaction, Chem. Asian. J., 16, 40534056 (2021)䠖(NMR)
7. M. Sai, +.XURXFKL3RWDVVLXPEDVH-catalyzed michael additions of allylic alcohols to DE-unsaturated
amides: scope and mechanistic insight, Adv. Synth. Catal., 363, 3585-3591 (2021)䠖(NMR)
8. M. Sai, A tetraarylpyrrole-based phosphine ligand for the palladium-catalyzed amination of aryl chlorides,
Adv. Synth. Catal., 363, 5422-5428 (2021)䠖(NMR)
9. H. Fukuo, T. Suzuki, J. Shimabukuro, 1 .RPXUD, H.-N. Tanaka, A. Imamura, H. Ishida, H. Ando,
Synthesis of diverse seleno-glycolipids via the transacetalization of selenoacetals, Eur. J. Org. Chem., 40,
5455-5467 (2021)䠖(NMR)
10. A. Alborzian Deh Sheikh, C. Akatsu, H.H.M. Abdu-Allah, Y. Suganuma, A. Imamura, H. Ando, H.
Takematsu, H. Ishida, T. Tsubata, The protein tyrosine phosphatase SHP-1 (PTPN6) but not CD45
(PTPRC) is essential for the ligand-Mediated regulation of CD22 in BCR-ligated B cells, J. Immunol.,206, 2544-2551 (2021)䠖(NMR)
11. 01DNDQR6+DQDVKLPD7+DUD..DED\DPD<$VDKLQD++RMR1.omura, H. Ando7.0
Nyholm, J.P. Slotte, M. Murata, FRET detects lateral interaction between transmembrane domain of EGF
receptor and ganglioside GM3 in lipid bilayers, Biochim. Biophys. Acta. Biomembr., 1863, 183623(2021)䠖(NMR)
12. 01DJDWD.7R\RQDJD E. Ishikawa, S. Haji, N. Okahashi, M. Takahashi, Y. Izumi, A. Imamura.
Takato, H. Ishida, S. Nagai, P. Illarionov, B.L. Stocker, M.S.M. Timmer, D.G. M. Smith, S.J. Williams,
T. Bamba, T. Miyamoto, M. Arita, B.J. Appelmelk, S. Yamasaki, Helicobacter pylori metabolites
exacerbate gastritis through C-type lectin receptors, J. Exp. Med., 218, 1 (2021)䠖(NMR)
13. 01DNDWR16KLUDQDJD07RPLRND+:DWDQDEH-.XULVX0.HQJDNX1.RPXUD, H. Ando, Y.
.LPXUD1.LRND.8HGD$%&$G\VIXQFWLRQDVVRFLDWHG with psychiatric disorders causes impairedcholesterol trafficking, J. Biol. Chem., 296, 100166 (2021)䠖(NMR)
14. ,*/X]LQD(3/LOOHKRM9/RFNDWHOO6:+\XQ.1/XJNH\A. Imamura, H. Ishida, C.W. Cairo, S.P.
Atamas, S.E. Goldblum, Therapeutic effect of neuraminidase-1–selective inhibition in mouse models of
bleomycin-induced pulmonary inflammation and fibrosis, J. Pharmacol. Exp. Ther., 376, 136-146(2021)䠖(NMR)
15. A.M. Vibhute, 1 .RPXUD, H.-N. Tanaka, A. Imamura, H. Ando, Advanced chemical methods forstereoselective sialylation and their applications in sialoglycan syntheses, Chem. Rec., 21, 1-31 (2021)䠖
(NMR)
16. P.-Y. Wong, A. Takeno, S. Takahashi, S.-W. Phang, A. Baharum, Crazing effect on the bio-based
conducting polymer film, Polymers, 13, 10.3390/polym13193425 (2021)䠖(SEM)
17. Y. Ikeda, H. Hamano, Y. Horinouchi, L. Miyamoto, T. Hirayama, H. Nagasawa, T. Tamaki, .
Tsuchiya, Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice, J. Trace Elem. Med.
Biol., 67, 126798 (2021)䠖(PL 㔞Ꮚ཰⋡䞉⺯ග⇥ගᑑ࿨ ᐃ⿦⨨)18. A. Mukaimine, T. Hirayama, H. Nagasawa, Asymmetric bismuth-rhodamines as an activatable

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fluorogenic photosensitizer, Org. Biomol. Chem., 19, 3611-3619 (2021)䠖(PL 㔞Ꮚ཰⋡䞉⺯ග⇥ගᑑ࿨ᐃ⿦⨨)..3 3DPXQJNDV, S. Hattori, T. Maruyama, M. Ebihara, T. Murai, Synthesis of 5-H thiazoles via
thioamide dianions and thioformamides: pyridylmethyl group on the nitrogen atom of thiazole promotes
the formation of 5-H thiazoles. Heterocycles, 103, 258-266 (2021)ʁ(MS, NMR)
..33DPXQJNDVT. Maruyama, T. Murai, Boron complexes of thiazole-bridged 1,5-bidentate nitrogen ligands:
synthesis and acid-responsive photophysical properties, Org. Biomol. Chem., 19, 6804-6811 (2021)ʁ(MS, NMR)
T. Murai, R. Wada, K. Iwata, Y. Maekawa, K. Kuwabara, M. Minoura, Primary phosphines andphosphine oxides with a stereogenic carbon center adjacent to the phosphorus atom: synthesis and antiMarkovnikov radical addition to alkenes, Organics, 2, 395-403 (2021)ʁ(MS, NMR)
<.XERWD, M. Nakazawa, J. Lee, R. Naoi, M. Tachikawa, T. Inuzuka, .)XQDELNL00DWVXL7.LP,
Synthesis of near-infrared absorbing and fluorescent bis(pyrrol-2-yl)squaraines and their halochromic
properties, Org. Chem. Front. 8, 6226-6243 (2021)ʁ(NMR, ෾ޭ‫ܯౕޭޭܮ‬, PL ྖࢢफི, ‫ྟޭܮ‬ޭथໍ଎ఈૹ஖, MS)
23. . )XQDELNL . <DPDGD + 0DWVXHGD < $ULVDZD 7 $JRX < .XERWD, T. Inuzuka, H. Wasada,
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24.

25.

26.

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28.
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30.

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PL ྖࢢफི, ‫ޭྟޭܮ‬थໍ଎ఈૹ஖). )XQDELNL, 7 *RWRK 5 .DQL T. Inuzuka, < .XERWD, Highly diastereo- and enantioselective
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properties of singly bay-linked dimeric perylene diimides, Chem. Eur. J., 27, 14081-14091 (2021)ʁ(MS)T. Sengoku, D. Ogawa, H. Iwama, T. Inuzuka, H. Yoda, A heavy-metal-free desulfonylative Giese-type
reaction of benzothiazole sulfones under visible-light conditions, Chem. Commun., 57, 9858-9861(2021)ʁ(MS). )XMLPRWR 6 7DNLPRWR 6 0DVXGD T. Inuzuka . 6DQDGD 0 Sakamoto, M. Takahashi, 5,11Diazadibenzo[hi,qr]tetracene: synthesis, properties, and reactivity toward nucleophilic reagents, Chem.
Eur. J., 27, 8951-8955 (2021)ʁ(MS)<.DZD]RH<,WDNXUDT. Inuzuka, S. Omura, D. Uemura, Structure–activity relationship study of theanti䇲obesity natural product yoshinone A, Chirality, 33, 226-232 (2021)ʁ(NMR).)XMLPRWR6,]DZD$7DNDKDVKLT. Inuzuka.6DQDGD06DNDPRWR<1DND\DPD0+LUDPRWR
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Mitsunaga, H. Tanaka, Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production
in human keratinocytes, J. Nat. Med., 75, 623-632 (2021)ʁ(NMR)<.DNXPX7071JX\HQ.<DPDXFKL, T. Mitsunaga, New benzoic acid and caffeoyl derivatives with
anti-inflammatory activities isolated from leaves of Ilex kaushue, Nat. Prod. Res., 12,1-9 (2021)ʁ(NMR).1DLWR, M. Yoshida<$GDFKL..DZDLO. Sakurada, .<DVKLUR, Tensile properties of cristobalitefilled epoxy resin, J. Appl. Polym. Sci., 138, app.50410(1-12) (2021)䠖(SEM, TG)
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associated with extended inflammation during endotoxemia in a diabetic mouse model. Front Cell. Dev.



Biol., 9, 623582 (2021)䠖(SEM)
35. S. Kutsumizu, A. Kawafuchi, Y. Yamamura, T. Udagawa, T. Otaki, M. Masuda, Y. Miwa, and K. Saito,
Stabilization of bicontinuous cubic phase and its two-sided nature produced by use of siloxane tails andintroduction of molecular nonsymmetry, Chem. Eur. J., 27, 10293-10302 (2021)䠖(CHO)
36. H. Ueda, R. Fukuta, T. Ohno, A. Moriyama, T. Himaki, H. Iwahashi, H. Moritomi, Assessment of
biological effects and harm to Japanese medaka due to carbonized carbon fibers generated by a pyrolysis
carbon fiber recycling process, J. Mater. Cycles Waste Manag., 23, 1071-1080 (2021)䠖䠄NGS䠅
37. F. Ito, R. Niwa, Y. Syaputri, Y. Ikagawa, T. Mizuno, M. Horie, H. Iwahashi, Draft genome sequence of
Lactiplantibacillus pentosus AWA1501, isolated from Awa-bancha, Microbiol. Resour. Announc., 10,e00518 (2021)䠖(NGS)
38. P. Pumkaeo, J. Takahashi, H. Iwahashi, Detection and monitoring of insect traces in bioaerosols, PeerJ,9, e10862H (2021)䠖䠄NGS䠅
39. S. Yolani, R. Niwa, H. Iwahashi, Effect of pH and salinity on lactic acid production and multiplication ofplantaricin plasmid genes of Lactobacillus plantarum COY 2906 isolated from virgin coconut oil. Res. J.
Biotechnol., 16, 1-8 (2021)䠖(NGS)
40. Y. Fukawa, Y. Mizuno, . .DZDGH, . 0LWVXNXUD, T. Yoshida, Novel (S)-selective hydrolase from
Arthrobacter VS.IRUNLQHWLFUHVROXWLRQRIF\FOLFDPLQHV Catalysts, 11, 809 (2021)䠖(NMR)
41. M.M. Rahman, S. Takashima, <2 .DPDWDUL< %DGU . 6KLPL]X$ 2NDGD Y. Inoshima, Putativeinternal control genes in bovine milk small extracellular vesicles suitable for normalization in quantitative
real time-polymerase chain reaction, Membranes, 11, 933 (2021)䠖(TEM)
42. M.M. Rahman, S. Takashima, <2 .DPDWDUL . 6KLPL]X $ 2NDGD Y. Inoshima, Comprehensive
proteomic analysis revealed a large number of newly identified proteins in the small extracellular vesiclesof milk from late-stage lactating cows, Animals, 11, 2506 (2021)䠖(TEM)
43. M.M. Rahman, S. Takashima, <2.DPDWDUL<%DGU<.LWDPXUD.6KLPL]X$2NDGDY. Inoshima,
3URWHRPLFSURILOLQJRIPLONVPDOOH[WUDFHOOXODUYHVLFOHVIURPERYLQHOHXNHPLDYLUXVဩLQIHFWHGFDWWOHSci.
Rep, 11, 2951 (2021)䠖(TEM)
44. M. Jason, T. Wega, Triyono, 0.RNHWVX, F.D. Ayu, Hydrochloric acid and/or sodium hydroxide-modified
zeolite y for catalytic hydrotreating of D-cellulose bio-oil, Indones. J. Chem., 21, 787-796 (2021)䠖(SEM,
IR, CHO)45. .01:LQ$'6RQDZDQHM. .RNHWVX, Synthesis of selenated tetracyclic indoloazulenes via iodine
and diorganyl diselenides, Org. Biomol. Chem., 19, 3199-3206 (2021)䠖(MS, NMR, IR)
46. T. Itoh, S. Fujita, 0.RNHWVX, T. Hashizume, Citrulluside H and citrulluside T from young watermelon
fruit attenuate ultraviolet B radiation-induced matrix metalloproteinase expression through thescavenging of generated reactive oxygen species in human dermal fibroblasts, Photodermatol.
Photoimmunol. Photomed., 37, 386-394 (2021)䠖(MS, NMR, IR)
47. 0 8NL\D . 0RWHJL ' 6DWR + .LPXUD + 6DWVX 0 .RNHWVX, M. Ninomiya, L.M.M. Myint, A.
Nishina, Effect of compounds from Moringa oleifera Lam. on in vitro non-alcoholic fatty liver disease(NAFLD) model system, Chem. Biodivers., 18, e2100243 (2021)䠖(MS, NMR, IR)
48. A.D. Sonawane, 0 .RNHWVX, Organocatalysed synthesis of selenium containing scaffolds, Curr.
Organocatalysis, 8, 5-26 (2021)䠖(MS, NMR, IR)
49. A.D. Sonawane, R.A. Sonawane, M. Ninomiya, 0.RNHWVX, Diorganyl diselenides: a powerful tool forthe construction of selenium containing scaffolds, Dalton Trans., 50, 12764-12790 (2021)䠖(MS, NMR,
IR)
50. M. ,WR$<DPDJXFKL'2VKLPD7.DWR06KLPD.<DPDGD, Enhancement of spin–orbit torques bychange in uniaxial in-plane magnetic anisotropy of Py/Pt bilayers on single crystal 128ƕ Y-Cut LiNbO3
substrate, Appl. Phys. Lett., 119, 152407 (2021)䠖(SEM, SPM)
51. <2KQR.+D\DVKL.<DPDGD, M. Shima, Textured growth of Co-Fe-Ga alloy films via topotactictransformation from highly oriented precursor and spinel oxide, Mater. Lett., 302, 130306 (2021)䠖(SEM,
SPM, XPS)
52. .+D\DVKL.<DPDGD, M. Shima, Estimation of the cation distribution in Co3-XNiXO4 X  synthesized from crystallized Co1-YNiY(OH)2 (X = 3Y) prepared by the uniform precipitation method, J.
Magn. Magn. Mater., 519, 167479 (2021)䠖(SEM)
53. .. Yamada60DVDNL0<DPDPRWR..RQGR<.XURNDZD<6KLRWD70RUL\DPD72QR+Yuasa,
M. Shima, Change of longitudinal spin Seebeck voltage with annealing in Y3Fe5O12 films formed bydensely packed nanocrystals, J. Magn. Magn. Mater., 535, 168093 (2021)䠖(SEM, SPM, XPS)

54. S.L. Higashi, M. Ikeda, Development of an amino sugar-based supramolecular hydrogelator with
reduction responsiveness, JACS Au, 1, 1639-1646 (2021)䠖䠄NMR, TEM, CD, 䝺䜸䝯䞊䝍䞊䠅
55. 1 6KLUDNDPL< .DZDNL 6/ +LJDVKL$ 6KLEDWD< .LWDPXUD 6$ +DQLIDK L.L. Wah, M. Ikeda,
Introduction of an oxidation-responsive 4-boronobenzyl group into an oligonucleotide through a
postmodification approach, Chem. Lett., 50, 1412-1415 (2021)䠖䠄NMR䠅
56. 16KLUDNDPL6/+LJDVKL<.DZDNL<.LWDPXUD$6KLEDWDM. Ikeda, Construction of a reductionresponsive oligonucleotide via a post-modification approach utilizing 4-nitrophenyl diazomethane,
Polymer J., 53, 741-746 (2021)䠖䠄NMR䠅
57. . ,VRJDZD0$VDQR0+\D]DNL..RJD0:DWDQDEH.6X]XNL7.RED\DVKL..DZDJXFhi, A.
,VKL]XND 6 .DWR + ,WR $ +DPDPRWR + .R\DPD . )XUXWD + 7DNHPRUL 7KLR[RWKLD]ROLGLQ
derivative, 4-OST, inhibits melanogenesis by enhancing the specific recruitment of tyrosinase-containing
vesicles to lysosome, J. Cell. Biochem., 112, 667-678 (2021)䠖䠄NMR䠅
58. 1.DPH\DPD<+LURNL)+LWRVKL<.RWDUR)0LWVXWDND7KLQ-film processing of polypropylene andpolystyrene sheets by a continuous wave CO2 laser with the Cu cooling base, Polymers, 13, 1448 (2021)䠖
(FTIR)
59. <2FKLDL.2JDZD<. Sawada, E. Yanase, Chemical transformation of oolongtheanin 3’-O-gallate inaqueous solution under heating conditions. Tetrahedron Lett., 73, 153140 (2021)䠖(MS, NMR, IR)
60. 5.$JUDKDUL 7 (QRPRWR + ,WR< 1DNDQR E. Yanase, T. Watanabe, A. Sadhukhan, S. Iuchi, M.
.RED\DVKL6. 3DQGD<<<DPDPRWR+.R\DPD([SUHVVLRQ*:$6RI 3*,3 LGHQWLILHV 6723dependent and STOP1-independent regulation of PGIP1 in aluminum stress signaling in Arabidopsis.
Front. Plant Sci., 774687 (2021)ʁ(NMR)
61. + $OWDLE . 1DNDPXUD 0 $EH < %DGU E. Yanase, I. Nomura, T. Suzuki, Differences in theconcentration of the fecal neurotransmitters GABA and glutamate are associated with microbial
composition among healthy human subjects. Microorganisms, 9, 1-15 (2021)䠖(HPLC)
62. H. Tange, D. Ishibashi, T. Nakagaki, Y. Taguchi, <2.DPDWDUL, H. Ozawa, N. Nishida, Liquid-liquid
phase separation of full-length prion protein initiates conformational conversion in vitro. J. Biol. Chem.,
296, 100367 (2021)ʁ(FTIR)
63. S. Yamashita, <2 .DPDWDUL 5 +RQGD$ 1LZD + 7RPLDWD$ +DUD . .XZDWD 0RQRPHULF Dsynuclein (aS) inhibits amyloidogenesis of human prion protein (hPrP) by forming a stable aS-hPrP
hetero-dimer. Prion, 15, 37-43 (2021)ʁ(NMR)
64. ..XPDEH, M. Chishima, H. Moritomi, Physico-chemical characterization of biomass, coal, and theirchars using kinetics and electrochemistry, Energy Rep., 7, 4437-4444 (2021)䠖䠄CHO, IR䠅
65. 5.XPDU<+D]DPD)2KDVKL+6-KD7.XPH, A fabrication method for type-II Ge clathrate filmby annealing of Ge film covered with Na layer, Thin Solid Films, 734, 138859/1-4 (2021)䠖(SEM, FTIR)
66. 5,LRND.<RUR]X<6DNDL5.DZDL1+DWDH.7DNDVKLPD*7DQDEH+:DVDGDM. Yoshimatsu,
Synthesis of azepino[1,2-a]indole-10-amines via [6+1] annulation of ynenitriles with reformatsky reagent,
Eur. J. Org. Chem., 2021, 1553-1558 (2021)ʁ(MS, NMR, IR, CHO)
67. S. Vafaei, A. Wolosz, C. Ethridge, U. Schnupf, N. Hattori, T. Sugiura, .0DQVHNL, Elucidation of thecrystal growth characteristics of SnO2 nanoaggregates formed by sequential low-temperature sol-gel
reaction and freeze drying, Nanomaterials, 11, 1738 (2021)䠖(TEM)
68. R.Z. Putra, M. Yoshida, A. Mitani, - .DWR, Preliminary investigation of flash sintering of
Li1.5Al0.5Ge1.5(PO4)3 solid electrolyte, J. Jpn. Soc. Powder Metall., 68, 494-499 (2021)䠖(SEM)
69. 7,\DVX0.XUDWDQL,,NHGD17DQDND<<DPDGDO. Sakurada, Simple measurement of carbon films
on copper tubes and their effect on corrosion, Open J. Compos. Mater., 11, 12-22 (2021)䠖(SEM, XPS,䝕䝆䝍䝹䝬䜲䜽䝻䝇䝁䞊䝥)
70. M. .XUDWDQL.<DPDNDZD5.XURQR<.DQR76DVDNL<<DPDGDO. Sakurada, Effect of repainting
process on atmospheric corrosion behavior of perforated panels, Mater. Sci. Appl., 12, 534-541 (2021)䠖
(SEM, XPS, 䝕䝆䝍䝹䝬䜲䜽䝻䝇䝁䞊䝥)
71. .8HPXUD, E. Yasuda, Y. Sugiyama, Improving the solubility of hexanuclear heterometallic extended
metal atom chain compounds in nonpolar solvents by introducing alkyl amine moieties, ACS Omega, 6,
18487-18503 (2021)䠖䠄NMR䠅
72. 16$EG5DKPDQ.0DWVXL6<DPDGDT. Itoh, Evaluation of hydrogenated amorphous silicon oxide
photo-absorber from quantum efficiency in thin-film solar cell by fourier transform photocurrent
spectroscopy, Mater. Trans., 62, 1263-1269 (2021) : (XPS)73. 5 .DMLQR Y. Ueno, (S)-5'-C-Aminopropyl-2'-O-methyl nucleosides enhance antisense activity incultured cells and binding affinity to complementary single-stranded RNA, Bioorg. Med. Chem., 30,
115925 (2021)䠖䠄NMR䠅
74. H. Ando, T. Imaizumi, Changes in electrical properties and void distribution of mung bean sprout during
hot water heating. Food Sci. Technol. Res., 27, 311-318 (2021)䠖䠄X ⥺ CT 䝇䜻䝱䞁䠅
75. T. Aoyagi, T. Oshima, T. Imaizumi, Quantitative characterization of individual starch grain morphology
using a particle flow analyzer. LWT-Food Science and Technology, 139, 110589 (2021)䠖䠄SEM, 䝣䝻䞊ᘧ⢏Ꮚീศᯒ⿦⨨䠅
76. T. 2VKLPD . .DWR T. Imaizumi, Effects of blanching on drying characteristics, quality, and pectin
nanostructures of dried cut-persimmons. LWT-Food Science and Technology, 143, 111094 (2021)䠖䠄SPM䠅
77. R.D.Y. Away, C. Takai-Yamashita, T. Ban, Y. Ohya, Photocatalytic properties of TiO2-SiO2 sandwich
multilayer films prepared by sol-gel dip-coating, Thin Solid Films, 720, 138522-138522 (2021)䠖(TEM,
SEM)
78. Y. Ohya+.DQDRND6,ZDWD&7DNDL-Yamashita, T. Ban, Dependence of electrical conductivity of ȕGa2O3 ceramics on oxygen partial pressure and formation of dislocations, J. Ceram. Soc. JAPAN, 129,254-260 (2021)䠖(TEM, SEM)
79. ⸝㇂ඖ⣖䠈ᒃᏳ㝯ᚿ䠈⏣୰ἲᖾ䠈ᒣ⏣ ㇏䠈Ḉ⏣ ಟ, 䜚䜣⬺㓟㖡㌾㉁⟶䜹䞊䝪䞁⓶⭷䛾 XPS ศᯒホ౯, ศᯒ໬Ꮫ䠈70䠈267-270 (2021)䠖(SEM, XPS, 䝕䝆䝍䝹䝬䜲䜽䝻䝇䝁䞊䝥)80. బ䚻ᮌၨே䠈⸝㇂ඖ⣖䠈ᒃᏳ㝯ᚿ䠈ຍ⣡భ┿䠈⏣୰ἲᖾ䠈ᒣ⏣ ㇏䠈Ḉ⏣ ಟ, 㖡⟶䛾䜹䞊䝪䞁⓶⭷䛾 XPS ศᯒ䛸⭉㣗ᣲື䛻䛚䜘䜌䛩ᙳ㡪, 㖡䛸㖡ྜ㔠䠈60䠈135-139 (2021)䠖(SEM, XPS, 䝕䝆䝍䝹䝬䜲䜽䝻䝇䝁䞊䝥)81. ຍ⣡భ┿䠈ᒃᏳ㝯ᚿ䠈⸝㇂ඖ⣖䠈బ䚻ᮌၨே䠈⏣୰ἲᖾ䠈ᒣ⏣ ㇏䠈Ḉ⏣ ಟ, 㖡⟶䛾䜹䞊䝪䞁⓶⭷౫ᏑᆺᏍ㣗ホ౯ヨ㦂ᾮ䛻䛚䛡䜛⭉㣗ᅉᏊ䛾ᙳ㡪, 㖡䛸㖡ྜ㔠䠈60䠈140-143 (2021)䠖(SEM, 䝕䝆䝍䝹䝬䜲䜽䝻䝇䝁䞊䝥)82. ⸝㇂ඖ⣖䠈ụ⏣ 㐩䠈ᒃᏳ㝯ᚿ䠈⏣୰ἲᖾ䠈᱇ᕝ᭸ஓ䠈ᯇᮧಇ♸䠈ᒣ⏣ ㇏䠈Ḉ⏣ ಟ, Ỉ㉁䝟䝍䞊
䞁䝎䜲䜰䜾䝷䝮䛻䜘䜛㓄⟶ᮦᩱ䛾⭉㣗஦౛ゎᯒ, 㖡䛸㖡ྜ㔠䠈60䠈144-149 (2021)䠖(SEM, XPS, 䝕䝆䝍䝹䝬䜲䜽䝻䝇䝁䞊䝥)83. ᇼ⏣ ⩧ྖ, ෆ⏣ ⿱ᕷ䠈⧄⥔⿵ᙉ䝁䞁䜽䝸䞊䝖䛻䛚䛡䜛⧄⥔䛾㓄ྥ䛜䜂䜃๭䜜㠃䛾䛫䜣᩿ᣲື䛻ཬ䜌䛩ᙳ㡪䠈䝁䞁䜽䝸䞊䝖ᕤᏛᖺḟㄽᩥ㞟䠈43䠈215-220 (2021)䠖䠄X ⥺ CT 䝇䜻䝱䞁䠅84. ኴ⏣ ㈗அ, ኱୵ 㝣ே, ᑠ⏣ ᫛⣖, ୖᆏ ⿱அ䠈኱㟁ຊ䝟䝹䝇䝇䝟䝑䝍䝸䞁䜾䜢⏝䛔䛯᭷ᶵᇶᯈ䜈䛾䝎䜲䝲䝰䞁䝗䝷䜲䜽䜹䞊䝪䞁ᡂ⭷, ⾲㠃ᢏ⾡, 73, 47-52 (2021)䠖䠄䝷䝬䞁ศග䠅‫≉ ۑ‬チ㸸
1. ᒸ ኟኸ, Ᏻ⸨ 㤶⧊, 䝅䜽䝻䝨䞁䝔䞁ㄏᑟయ䜎䛯䛿䝅䜽䝻䝦䜻䝉䞁ㄏᑟయཬ䜃䛭䛾〇㐀᪉ἲ, ≉㢪
2021-166543, 2021䠖(MS, NMR)
2. டᒣ ᒎ࿴, ྜྷ⏣ ᘯᶞ, ⚟⏣ ‶Ꮥ, ᒣ⏣ ⪔ኴ㑻, ῝ᕝ ோ䠈䝺䞊䝄䞊䛻䜘䜛ⷧ⭷㒊䛾ᙧᡂ᪉ἲ䠈≉㢪 2021-089806䠖(FTIR)‫ⴭ ۑ‬᭩㸸
1. Ọ⃝ ⚽Ꮚ, 䛜䜣ᚤᑠ⎔ቃ䜢ᶆⓗ䛸䛧䛯἞⒪⸆䛸⪏ᛶ 8.⭘⒆ෆ䛾ప㓟⣲䞉పᰤ㣴⎔ቃ䜢฼⏝䛧䛯⸆๣䛾㛤Ⓨ, ᐇ㦂་Ꮫ, 39, (2021) 䠖 (෇஧Ⰽᛶศᩓィ CD, ㄏᑟ⤖ྜ䝥䝷䝈䝬Ⓨගศᯒ⿦⨨ ICP)
2. ྜྷᮧ ⤋ᕼ, ᒸ⏣ ⱥᚿ 䛆จᅛ䛸⅖⑕䛾䜽䝻䝇䝖䞊䜽䛇ឤᰁᛶ䠄ᩋ⾑⑕ᛶ䠅⮚ჾ㞀ᐖ䛸䜾䝸䝁䜹䝸䝑䜽䝇,
ICU 䛸 CCU, 329-339, ་Ꮫᅗ᭩ฟ∧, 2021: (SEM)
3. ୖ㇂ 㑈, ᒸ⏣ ⱥᚿ, 䛆䝅䝵䝑䜽⟶⌮ 2021-'22-䜺䜲䝗䝷䜲䞁䚸䝇䝍䞁䝎䞊䝗䚸ㄽⅬ䛭䛧䛶⚾ぢ-䛇䝅䝵䝑䜽䛾⑓ែ⏕⌮ 䝅䝵䝑䜽䛻క䛖⾑⟶ෆ⓶യᐖ, ᩆᛴ䞉㞟୰἞⒪, 679-687, ⥲ྜ་Ꮫ♫, 2021: (SEM)‫ ۑ‬ཧ⪃㈨ᩱ㸸
1. 㝰㒊 ࿴ᘯ䠈ᗫᲠ≀⣔ᮌ㉁䝞䜲䜸䝬䝇䛛䜙䛾ప䝁䝇䝖ᾮయ⇞ᩱ〇㐀ᢏ⾡䠈໬Ꮫᕤᴗ䠈72䠈581-588䠈
2021䠖䠄CHO, ICP䠅

4. ᶵჾศᯒศ㔝ᩍဨࡢᩍ⫱࣭◊✲άື➼1) ᩍ⫱άື
1. ࠕ㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉๰⸆ேᮦ⫱ᡂᩍ⫱ࣉࣟࢢ࣒ࣛࠖ2 ༢఩㸦15 ᅇࡢ࠺ࡕ 1 ᅇࢆᢸᙜ㸧2) ◊✲άື
ࠑཎⴭㄽᩥ࣭ⴭ᭩➼ࠒ
1. Rahman MM, Takashima S, Kamatari YO, Badr Y, Shimizu K, Okada A, Inoshima Y. Putative Internal
Control Genes in Bovine Milk Small Extracellular Vesicles Suitable for Normalization in Quantitative
Real Time-Polymerase Chain Reaction. Membranes (Basel). 11, 933 (2021).
2. Inden M, Takagi A, Kitai H, Ito T, Kurita H, Honda R, Kamatari YO, Nozaki S, Wen X, Hijioka M,
Kitamura Y, Hozumi I. Kaempferol Has Potent Protective and Antifibrillogenic Effects for ĮSynuclein Neurotoxicity In Vitro. Int J Mol Sci. 22, 11484 (2021).
3. Hirata Y, Motoyama M, Kimura S, Takashima M, Ikawa T, Oh-Hashi K, Kamatari YO. Artepillin C,
a major component of Brazilian green propolis, inhibits endoplasmic reticulum stress and protein
aggregation. Eur J Pharmacol. 912, 174572 (2021).
4. Rahman MM, Takashima S, Kamatari YO, Shimizu K, Okada A, Inoshima Y. Comprehensive
Proteomic Analysis Revealed a Large Number of Newly Identified Proteins in the Small Extracellular
Vesicles of Milk from Late-Stage Lactating Cows. Animals (Basel). 11, 2506 (2021).
5. Hayashi T, Kawasaki M, Kamatari YO, Oda M. Protein structure and analysis single-chain Fv
antibody covalently linked to antigen peptides and its structural evaluation. Anal Biochem. 629,
114312, (2021).
6. Tanaka N, Kimura S, Kamatari YO, Nakata K, Kobatake Y, Inden M, Yamato O, Urushitani M, Maeda
S, Kamishina H. In vitro evidence of propagation of superoxide dismutase-1 protein aggregation incanine degenerative myelopathy. Vet J. 274, 105710, (2021).
7. Tange H, Ishibashi D, Nakagaki T, Taguchi Y, Kamatari YO, Ozawa H, Nishida N. Liquid-liquid
phase separation of full-length prion protein initiates conformational conversion in vitro. J Biol Chem.
296, 100367, (2021).
8. Rahman MM, Takashima S, Kamatari YO, Badr Y, Kitamura Y, Shimizu K, Okada A, Inoshima Y.
Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected cattle.
Sci Rep. 11, 2951, (2021).
ࠑᏛ఍Ⓨ⾲ࠒ
㸦ᅜ㝿Ꮫ఍㸧
1. Y. O. Kamatari, S. Yamashita, R. Honda, & K. Kuwata, Monomeric D-synuclein (DS) inhibits
amyloidogenesis of human prion protein (hPrP) by forming a stable DS-hPrP hetero-dimer, 22ndInternational Society of Magnetic Resonance Conference (ISMAR), 2021/8/24, Online.
3) ⿵ຓ㔠㛵㐃᥇ᢥ≧ἣ
1. 2020㹼2022 ᖺᗘ ⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲(B) (୍⯡) (ศᢸ)ࠕࣇ࢓࣮࣐ࢥࣇ࢛࢔ࣔࢹࣝࢆ
Ỵᐃࡍࡿィ⟬⛉Ꮫᢏ⾡ࡢ☜❧࡜ᢠࣉࣜ࢜ࣥ໬ྜ≀ࡢ㛤Ⓨࠖ㸦㙊㊊㸧
2. 2020㹼2022 ᖺᗘ ⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲(C) (୍⯡) (ศᢸ)ࠕ᪕ẟ⹸ศἪࢱࣥࣃࢡ㉁࡟ࡼ
ࡿᐟ୺➽⫗⣽⬊ኚ␗ࡢศᏊ⏕≀Ꮫⓗ࠾ࡼࡧᵓ㐀⏕≀Ꮫⓗゎᯒࠖ㸦㙊㊊㸧
3. 2020㹼2021 ᖺᗘ ⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲(C) (୍⯡) (ศᢸ)ࠕ≟ࡢኚᛶᛶ⬨㧊⑕ࢆ㉳ࡇࡍ
ኚ␗ SOD1 ⺮ⓑ㉁ࡢ❧యᵓ㐀ゎᯒ࡜἞ ⒪ᇶ┙ࡢᵓ⠏ࠖ㸦㙊㊊㸧㸦ᙺဨ➼㸧
1. ᪥ᮏ⏕≀≀⌮Ꮫ఍ศ㔝ูᑓ㛛ጤဨ㸦㙊㊊㸧
2. ᒱ㜧ᵓ㐀⏕≀Ꮫ࣭་Ꮫ࣭ㄽ⌮ⓗ๰⸆◊✲఍஦ົᒁ㸦㙊㊊㸧
3. Molecules Editorial Board㸦㙊㊊㸧ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝
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TEL : 058-293-2055
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࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ฼⏝ࡢᡭᘬࡁ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

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࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ௧࿴  ᖺᗘᩍ⫱カ⦎ཷㅮ⪅ᩘ࣭≉Ṧ೺ᗣデ᩿㸦㟁㞳㸧ཷデ⪅ᩘ ௧࿴  ᖺᗘ᪋タ฼⏝≧ἣ ᨺᑕ⥺ᴗົᚑ஦⪅ࡢᴗ⦼ㄽᩥ➼㸦㸧 ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝ᩍဨࡢᩍ⫱࣭◊✲άື➼‫ ی‬ศ㔝㛗ᣵᣜᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝㛗 ≟ሯಇᗣᨺᑕᛶྠ఩ඖ⣲㸦RI㸧ᐇ㦂ศ㔝ࡣࠊ2016 ᖺ 4 ᭶ࡼࡾࢭࣥࢱ࣮ࡢศ㔝ෆ⤌⧊࠿ࡽ⊂❧ࡋࡓ୍ศ㔝࡜࡞ࡾࠊ⌧ᅾ࡟⮳ࡗ࡚࠸ࡲࡍࠋⓎ㊊࠿ࡽ 6 ᖺࡣࠊᮌෆྡ㄃ᩍᤵࢆศ㔝㛗࡜ࡋ࡚ࠊ඲Ꮫᨭ᥼᪋タ࡜ࡋ࡚ࡢᶵ⬟ᙉ໬࡟ࡘ࡞ࡀࡿᵝࠎ࡞᪋⟇ࢆ⾜ࡗ࡚ࡁࡲࡋࡓࠋ౛࠼ࡤࠊ2017 ᖺᗘ࡟ࡣᨺᑕ⥺ᴗົᚑ஦⪅ࡢⓏ㘓ไᗘࢆᨵᐃࡋࠊᏛ
ෆእࡢᨺᑕ⥺᪋タ฼⏝⪅ࡀࡼࡾ฼⏝ࡋࡸࡍ࠸ไᗘ࡜ࡋࡲࡋࡓࠋࡲࡓࠊ2021 ᖺᗘ࡟ࡣᏛእ࠿ࡽࡢ᪋タ฼⏝ᕼᮃ⪅࡟ᑐࡍࡿཷクヨ㦂ไᗘࢆᩚഛࡋࠊᆅᇦ㈉⊩ࡢ㠃࡛ࡶせᮃ࡟ᛂ࠼ࡽࢀࡿศ㔝࡜࡞ࡾࡲࡋࡓࠋ
୍᪉ࠊ᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕ᑐ⟇࡜ࡋ࡚ࠊ2020 ᖺᗘ࠿ࡽᨺᑕ⥺ᴗົᚑ஦⪅ࡢᩍ⫱カ⦎ࡢᐇ᪋᪉ἲࢆ
኱ࡁࡃኚ㠉ࡋࡲࡋࡓࠋึࡵ࡚⟶⌮༊ᇦ࡟ධࡿ᪂つⓏ㘓⪅࡟ᑐࡋ࡚ࡣࠊᮾி኱Ꮫ࡜ྡྂᒇ኱Ꮫࡢ࢔࢖ࢯࢺ࣮
ࣉ⥲ྜࢭࣥࢱ࣮ࡀᥦ౪ࡍࡿࠕe-learning RI ㅮ⩦఍ࠖࢆ฼⏝ࡋࡓᩍ⫱カ⦎ࢆᐇ᪋ࡋࠊཷㅮ⪅ࡢᏳ඲࡟㓄៖ࡋࡘࡘᩍ⫱カ⦎ࢆᐇ᪋ࡍࡿయไࢆ㠀ᖖ᫬ୗ࡛ࡶ⥔ᣢࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋࡑࡋ࡚ࠊ2020 ᖺᗘࡼࡾᮾᾏᅜ
❧኱ᏛᶵᵓⓎ㊊ࢆዎᶵ࡜ࡋ࡚ྡྂᒇ኱Ꮫ࡜ࡢ㐃ᦠࡀᵝࠎ࡞㠃࡛ጞࡲࡗࡓࡇ࡜ࡶ࠶ࡾࠊ2021 ᖺᗘࡣྡྂᒇ኱
Ꮫࡢ e-learning ࢩࢫࢸ࣒ࢆά⏝ࡋࡓᩍ⫱カ⦎ࢆᣑ඘ࡋ࡚ᘬࡁ⥆ࡁᐇ᪋ࡍࡿࡇ࡜࡜ࡋࡲࡋࡓࠋ2022 ᗘ௨㝆ࡶᮾᾏᅜ❧኱Ꮫᶵᵓࡢᯟ⤌ࡳࢆά⏝ࡋ࡞ࡀࡽᏛෆእࡢᨺᑕ⥺᪋タ฼⏝⪅ࡢ౽ᐅࢆᅗࡗ࡚࠸ࡁࡲࡍࠋ
㏆ᖺࠊ⏕࿨⛉Ꮫ㡿ᇦࡢ◊✲࡛ࡣࠊ ᐃᢏ⾡ࡸᶆ㆑ἲ㛤Ⓨࡢⴭࡋ࠸㐍Ṍ࡟ࡼࡾࠊ㠀ᐦᑒ RI ᶆ㆑≀ࢆ⏝࠸࡞࠸᪂ࡓ࡞ศᯒ᪉ἲࢆ฼⏝ࡍࡿᶵ఍ࡀᅽಽⓗ࡟ቑ࠼࡚࠸ࡲࡍࠋࡋ࠿ࡋࠊ๰⸆࡟࠾ࡅࡿ᪂つ໬ྜ≀ࡢࣔࢹࣝື
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ࡍࠋࡇࡢࡇ࡜ࢆ㋃ࡲ࠼ࠊRI

ᐃࡸ࢖࣓࣮ࢪࣥࢢタഛࡢಖᏲ࣭ᩚഛࠊ࠾ࡼࡧࠊRI ࢖࣓࣮ࢪࣥࢢᢏ⾡࡜㉁㔞ศᯒᢏ⾡࡜ࢆ⤌ࡳྜࢃࡏࡓ᪂ࡓ࡞ゎᯒࡀ࡛ࡁࡿタഛࡢᩚഛ➼ࢆ࡛ࡁࢀࡤ࡜⪃࠼࡚࠸ࡲࡍࠋ
௚᪉ࠊ⮬↛ᨺᑕ⥺ࡢ ᐃࡣᆅ⌫⎔ቃࡢኚ㑄ࡸ⌧ᅾࡢ≧ἣࢆ▱ࡿ㔜せ࡞ศᯒࢹ࣮ࢱ࡜࡞ࡾࡲࡍࠋᮏ᪋タ࡟ࡣ⮬↛ᨺᑕ⥺ ᐃࡢࡓࡵࡢ Ge ༙ᑟయ᳨ฟჾࢆ 2 ྎタ⨨ࡋ࡚࠾ࡾࠊᴟᆅ◊࡜ࡢඹྠ◊✲࡛ά⏝ࡍࡿ࡜ඹ࡟ࠊ
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≉௵ᩍᤵ(ศ㔝㛗)ຓᩍ(2) ᑓ௵⫋ဨ
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ᾮయࢩࣥࢳ࣮ࣞࢩࣙࣥ࢝࢘ࣥࢱ࣮

Tri-Carb2900TR

ࣃࢵ࣮࢝ࢻᾮయࢩࣥࢳ࣮ࣞࢩࣙࣥ࢝࢘ࣥࢱ࣮

LSC-6101B

࢔ࣟ࢝J࢝࢘ࣥࢱ࣮

1480WIZARDࣃ࣮࢚࣐࣮࢟ࣥࣝ

ࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ࢔ࢼࣛ࢖ࢨ࣮

BAS-2500ᐩኈࣇ࢕࣒ࣝ

࣐࢖ࢡࣟࣉ࣮ࣞࢺ࣮ࣜࢲ࣮

1450 Microbeta TRILUXࣃ࣮࢚࣐࣮࢟ࣥࣝ

ࢭࣝࣁ࣮࣋ࢫࢱ࣮

FilterMate-96ࣃ࣮࢚࣐࣮࢟ࣥࣝ

Ge ༙ᑟయ᳨ฟჾ

GEM20, MCA-7700

SEIKO EG&G(ORTEC)

AlphaGUARD

PQ2000Genitron

GM ࢧ࣮࣋࢖࣓࣮ࢱ

TGS-133, TGS-136, TGS-146, TGS-121

࢔ࣟ࢝ࢩࣥࢳ࣮ࣞࢩࣙࣥࢧ࣮࣋࢖࣓࣮ࢱ

ICS-311, TCS-171, TCS-172, TCS-163

࢔ࣟ࢝

3H/ C ࢧ࣮࣋࢖࣓࣮ࢱ

TPS-303࢔ࣟ࢝E⥺⏝ࢧ࣮࣋࢖࣓࣮ࢱ LucrestTCS-1319H

᪥❧࢔࣓ࣟ࢝ࢹ࢕࢝ࣝ

ș⥺ࡢ྾཰ᐇ㦂ᶵ

GMB㸫1ᓥὠ⌮໬ჾᲔ

J⥺ࢫ࣌ࢡࢺ࣓࣮ࣟࢱ

JSM-102࢔࣮ࣟ࢝࣋ࢩࢵࢡࢫࢣ࣮࣮ࣛ

TDC-105, GM-5004

࢔ࣟ࢝⎔ቃᨺᑕ⥺ࣔࢽࢱ Radi

PA-1100ᇼሙಶே⿕ࡤࡃ⥺㔞ィ࣐࢖ࢻ࣮ࢬ࣑ࢽ

PDM-101, PDM-102, PDM-111, PDM-117

࢔ࣟ࢝

14

✵Ẽ୰ H ă C ᤕ㞟⿦⨨HCM-101B

࢔ࣟ࢝ྍᦙᆺࢲࢫࢺࢧࣥࣉ࣮ࣛ

DSM-361B

࢔ࣟ࢝ࣁ࢖࣒࢚࣎ࣜ࢘࢔ࢧࣥࣉ࣮ࣛ

HV-500F, HV-500R

ᰘ⏣⛉Ꮫࢩࢫࢸ࣒⺯ග㢧ᚤ㙾

BX51/U-HGLGPS࢜ࣜࣥࣃࢫ㢧ᚤ㙾᧜ᙳ⏝ࢹࢪࢱ࣓ࣝ࢝ࣛDIGITAL SIGHT DS-Fi1

ࢽࢥࣥ

14

3

3

ࢡ࣮ࣜࣥ࣋ࣥࢳ

MCV-91BNS-PJ

ࣃࢼࢯࢽࢵࢡ

CO2 ࢖࣮ࣥ࢟ࣗ࣋ࢱ࣮

4020

ᮅ᪥ࣛ࢖ࣇ

༟ୖᆺ㉸㐲ᚰᶵ

Optima TLX

࣋ࢵࢡ࣐࣐ࣥ࢖ࢡࣟ෭༷㐲ᚰᶵ

3700

ࢡ࣎ࢱ

෭༷㐲ᚰᶵ

CF15D2᪥❧෭༷㐲ᚰᶵ

S500FRࢡ࣎ࢱ㐲ᚰ⃰⦰ᶵ㸩ప ࢺࣛࢵࣉVC-12S, VA-120

ࢱ࢖ࢸࢵࢡ

⣧Ỉ/㉸⣧Ỉ〇㐀⿦⨨

EQA-3S࣑࣏ࣜ࢓ࣂ࢖࢜ࣁࢨ࣮ࢻ࢟ࣕࣅࢿࢵࢺ

MHE-91AB3-PJ

ࣃࢼࢯࢽࢵࢡ

࣮࢜ࢺࢡ࣮ࣞࣈ

SX-500

TOMY

༟ୖ㐲ᚰᶵ

2370T

࣡ࢣࣥ

ᑠᆺ㐲ᚰᶵ DISKBOY

FB-8000

KURABOࣁ࢖ࣈ࣮ࣜ࢜ࣈࣥ

HB-80

ࢱ࢖ࢸࢵࢡ

ࣄ࣮ࢺࢩ࣮࣮ࣛ

PC-300

FUSࣂ࢖࢜ࢩ࢙࣮࣮࢝

Wave-PRࢱ࢖ࢸࢵࢡࣃ࣮࣡ࢧࣉࣛ࢖

164-5052

Bio-Radࢺࣛࣥࢫ࢖࣑ࣝࢿ࣮ࢱ

LM-26Eࣅ࣮࢚࣒ᶵჾGFP ࢥࣥࣂ࣮ࢺࣉ࣮ࣞࢺ

38-0242-01

ࣅ࣮࢚࣒ᶵჾ

ⓑⰍගࢥࣥࣂ࣮ࢺࣉ࣮ࣞࢺ

38-0191-01

ࣅ࣮࢚࣒ᶵჾ㟁Ꮚኳ⛗PB303-SDR/21

࣓ࢺ࣮ࣛpH ࣓࣮ࢱ࣮

S20KIT࣓ࢺ࣮ࣛ࣎ࣝࢸࢵࢡࢫ࣑࢟ࢧ࣮

G560

࢚࣒࢚ࢫ

࣎ࣝࢸࢵࢡࢫ࣑࢟ࢧ࣮

VORTEX GENIE2

࢚࣒࢚ࢫ

HD-200N࢔ࢬ࣡ࣥᜏ ᣺┞Ỉᵴ㸦ࣘࢽࢧ࣮ࣔࢩ࢙࣮࣮࢝㸧㢼ᚠ⎔஝⇱ᶵ

NTS-1300ᮾி⌮໬ჾᲔ

࢛࣮࢘ࢱ࣮ࣂࢫ࢖࣮ࣥ࢟ࣗ࣋ࢱ

ࣃ࣮ࢯࢼࣝ 11ࢱ࢖ࢸࢵࢡࣃ࣮ࢯࢼࣝ࢖࣮ࣥ࢟ࣗ࣋ࢱ࣮

LTI-2000ᮾி⌮໬ჾᲔ

࢖࣮ࣥ࢟ࣗ࣋ࢱ࣮

IS600

࣐ࣖࢺ⛉Ꮫ

ࢤࣝࢻࣛ࢖࣮ࣖ

AE-3750+1426

࢔ࢺ࣮࣍ࢵࢺࣉ࣮ࣞࢺ

PC-400Dࢥ࣮ࢽࣥࢢ㉸㡢ἼὙίᶵ

AU-301U࢔࢖࣡་⛉ᕤᴗ

㉸㡢ἼὙίჾ

UT-305ࢩ࣮ࣕࣉ඲⮬ື〇ịჾ

FM-120D࣍ࢩࢨ࢟㟁ᶵ

ື≀㣫⫱ࣇ࣮ࢻ

TH-2300༓௦⏣ಖᏳ⏝ရ

RI ởᰁᐇ㦂ື≀஝⇱⿦⨨

68100

᱓࿴㈠᫆

Ⓨ㟁ᶵ

EU28is

HONDAࢤࣀ࣒◊✲Ჷ RI ᐇ㦂ᐊ
ᶵჾྡ

ᆺᘧ

࣓࣮࣮࢝

ᾮయࢩࣥࢳ࣮ࣞࢩࣙࣥ࢝࢘ࣥࢱ࣮

LSC-7200࢔ࣟ࢝

J ࢝࢘ࣥࢱ࣮

ARC-7001࢔ࣟ࢝Ge ༙ᑟయ᳨ฟჾ

GEM25 MCA7SEIKO EG&G(ORTEC)

GM ࢧ࣮࣋࢖࣓࣮ࢱ

TGS-146࢔ࣟ࢝ࣂ࢖࢜ࣁࢨ࣮ࢻ࢟ࣕࣅࢿࢵࢺ

NSC-ϩA-1200

ࢲࣝࢺ࣮ࣥ࢜ࢺࢡ࣮ࣞࣈ

ES-315ࢺ࣑࣮⢭ᕤᑠᆺᚤ㔞㧗㏿㐲ᚰᶵ

Microfuge 20R࣋ࢵࢡ࣐࣭ࣥࢥ࣮ࣝࢱ࣮

࣐࢖ࢡࣟ෭༷㐲ᚰᶵ

3700

ࢡ࣎ࢱ

ᚤ㔞⏝㐲ᚰ⃰⦰ᶵ

MV-100ࢺ࣑࣮⢭ᕤᜏ ᣺┞Ỉᵴ㸦ࣘࢽࢧ࣮ࣔࢩ࢙࣮࣮࢝㸧NTS-1300ᮾி⌮໬ჾᲔ

඲⮬ື〇ịჾ

FM-120D࣍ࢩࢨ࢟3 ฼⏝ࡢᡭᘬࡁ
1. ᪋タࡢᴫせྠ᪋タࡣᒱ㜧኱Ꮫᰗᡞᆅ༊ࡢ༡ᮾ࡟఩⨨ࡋ࡚࠸ࡿࠋ᫛࿴ 57 ᖺࠊᰗᡞ࢟ࣕࣥࣃࢫ࡟ 352 m2 ࡢᨺᑕᛶྠ
఩ඖ⣲◊✲᪋タ㸦⌧ᅾࡢ RI ◊✲Ჷ㸧ࡀ᪂⠏ࡉࢀࠊࡑࡢᖺࡢ 10 ᭶࡟౑⏝ࢆ㛤ጞࡋࡓࠋ୍᪉ࠊᖹᡂ 8 ᖺᗘ࡟ࡣ㑇ఏᏊᐇ㦂᪋タ㸦⌧ᅾࡢࢤࣀ࣒◊✲Ჷ㸧ࡀ᪂⠏ࡉࢀࠊ᪋タෆ㸯㝵࡟ 99 m2 ࡢ RI ᐇ㦂ᐊ㸦P2㸧ࡀタ⨨ࡉࢀࡓࠋᨺᑕ⥺⥲ྜ⟶⌮ࢩࢫࢸ࣒ࡶࡇࡢ᫬࡟ᑟධࡋࠊRI ◊✲Ჷ࡜ࢤࣀ࣒◊✲Ჷ RI ᐇ㦂ᐊࡢ୍ᣓ⟶⌮ࢆ⾜ࡗ࡚࠸ࡿࠋ

ࠑRI ◊✲Ჷࠒࠑࢤࣀ࣒◊✲Ჷ RI ᐇ㦂ᐊࠒ୺࡟ࠊᚤ㔞࡞⏕యศᏊࡢᣲືࢆ㏣㊧ࡍࡿࡓࡵࠊ㠀ᐦᑒࡢ RI ヨ⸆ࢆ⏝࠸ࡓᐇ㦂◊✲ࢆ⾜ࡗ࡚࠸ࡿ᪋タ࡛࠶ࡾࠊᨺᑕ⥺ྲྀᢅ୺௵⪅ࡢ┘╩ࡢࡶ࡜ࠊᏳ඲⟶⌮ࢆ⾜ࡗ࡚࠸ࡿࠋࡲࡓࠊᖹᡂ 23 ᖺ⚟ᓥ➨୍ཎᏊຊⓎ㟁ᡤ஦ᨾ௨㝆ࠊ⎔ቃᨺᑕ⥺ィ ࡢタഛ࣭ᢏ⾡࡟ࡶຊࢆධࢀ࡚࠸ࡿࠋ᪋タ⤒ᖺ࡟ࡼࡾᖹᡂ 23 ᖺᗘࡣ RI ◊✲Ჷࡢእᅇࡾ RI ᤼Ỉ⟶ࢆ᭦᪂ࡋࠊᖹᡂ 24 ᖺᗘ࡟ࡣ RI ◊✲Ჷᒇ
ෆ RI ᤼Ỉ⟶ཬࡧ㈓␃ᵴ➼኱つᶍ࡞᪋タᨵಟࢆᐇ᪋ࡋࡓࠋᖹᡂ 28 ᖺ 2 ᭶࡟ᨺᑕᛶྠ఩ඖ⣲⟶⌮ᐊ་Ꮫ᪋タࡀᗫṆࡉࢀࠊᖹᡂ 28 ᖺᗘࡼࡾᨺᑕᛶྠ఩ඖ⣲⟶⌮ᐊᰗᡞ᪋タࡀࠊRI ᐇ㦂ศ㔝࡜࡞ࡗࡓࠋ
୺࡞฼⏝ᑐ㇟⪅ࡣࠊ඲Ꮫࡢᩍဨ࣭Ꮫ⏕➼࡛࠶ࡿࠋຍ࠼࡚ࠊ௧࿴ 3 ᖺᗘࡼࡾཷクヨ㦂ไᗘࡶᩚഛࡋࠊᏛ
እ࠿ࡽࡢ᪋タ฼⏝ࡶཷࡅධࢀࡿែໃࢆᩚ࠼ࡓࠋᏛእࡢ㧗࢚ࢿࣝࢠ࣮ຍ㏿ჾ◊✲ᶵᵓ࣭SPring-8࣭ASRC ➼ࡢຍ㏿ჾ᪋タࡢ฼⏝⪅࡟ࡘ࠸࡚ࡶࠊἲ௧ୖࠊ஦๓࡟ᨺᑕ⥺ᴗົᚑ஦࡟㛵ࡍࡿᩍ⫱カ⦎ࡸ೺ᗣデ᩿ࡀᚲせ࡟࡞ࡿࡓࡵࠊᏛእࡢᨺᑕ⥺㛵㐃᪋タ฼⏝ᕼᮃ⪅ࡢ❆ཱྀ࡜ࡋ࡚ᑐᛂࡋ࡚࠸ࡿࠋ



2. Ⓩ㘓ࡢᡭ⥆ࡁᨺᑕᛶྠඖ⣲➼ࡢྲྀᢅ࠸ࠊ⟶⌮ཪࡣࡇࢀ࡟௜㝶ࡍࡿᴗົ࡟

ྛᏛ㒊࣭ࢭࣥࢱ࣮➼࠿ࡽⓏ㘓⪅ࡢ⏦ㄳᚑ஦ࡍࡿࡓࡵࠊ⟶⌮༊ᇦ࡟❧ࡕධࡿࡓࡵ࡟ࡣࠊᩍ⫱カ⦎࡜೺ᗣデ᩿ࢆཷࡅࡓᚋ࡟ࠊᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝㛗ࡢᢎㄆࢆᚓ

ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝࡚ࠊᴗົᚑ஦⪅࡜࡞ࡿᚲせࡀ࠶ࡿࠋⓏ㘓⪅ࡢᩍ⫱カ⦎࣭೺ᗣデ᩿‫ ۔‬ᩍ⫱カ⦎4㹼11 ᭶㡭ึᚰ⪅ᩍ⫱ࠊᖺḟᩍ⫱ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝㛗ᢎㄆ᪂つⓏ㘓⪅ཬࡧ⥅⥆Ⓩ㘓⪅ࡣୖࡢᮇ㛫୰࡟ཷㅮࠋ
ᨺᑕ⥺ᴗົᚑ஦⪅Ⓩ㘓‫ ۔‬೺ᗣデ᩿
4 ᭶ࠊ10 ᭶㡭Ꮫ⏕

6 ᭶ࠊ12 ᭶㡭⫋ဨ⟶⌮༊ᇦ࡬ࡢ❧ධ᪋タ࡬❧ධࡿ๓࡜❧ධࡗࡓᚋ࡟࠾࠸࡚ࡣࠊᏛ⏕ࡣ 1 ᖺࢆ㉸࠼࡞࠸ᮇ㛫ࡈ࡜ࠊ⫋ဨࡣ 6 ࣨ᭶ࢆ㉸࠼࡞࠸ᮇ㛫ࡈ࡜࡟ཷデࠋ

3. ᢎㄆ౑⏝᰾✀࠾ࡼࡧᩘ㔞
RI ◊✲Ჷ

༢఩㸸MBqࢤࣀ࣒◊✲Ჷ RI ᐇ㦂ᐊ༢఩㸸MBq

ᖺ㛫
౑⏝ᩘ㔞

3 ᭶㛫
౑⏝ᩘ㔞

1 ᪥᭱኱
౑⏝ᩘ㔞

᰾✀

ᖺ㛫
౑⏝ᩘ㔞

3 ᭶㛫
౑⏝ᩘ㔞

1 ᪥᭱኱
౑⏝ᩘ㔞

45

555

555

18.5

32

3700

3700

148

36

37

37

3.7

33

1850

1850

148

3.7

35

S

5920

5920

148

1.85

3

H

7400

7400

185

᰾✀
Ca
Cl

40

K

110m

Ag

109

37
11.1

37
11.1

P
P

37

37

3.7

14

C

3700

3700

74

125

I

2960

1480

74

90

Sr

9.25

9.25

0.185

203

Hg

185

148

1.85

51

185

185

37

22

Na

Cd

74

74

3.7

32

2590

2590

74

33

1850

1850

74

35

S

1850

1850

74

99m

Tc

11100

11100

370

59

Fe

3.7

P
P

74

74

131

I

740

333

3.7

86

Rb

185

185

5.55

3

H

7400

7400

259

14

C

4440

4440

74

51

Cr

370

370

74

90

9.25

9.25

0.185

Sr

Cr

* ➨ 4 ࢺ࣮ࣞࢧ࣮ᐇ㦂ᐊ㸦୺࡟ື≀ᐇ㦂㸧࡛౑⏝࡛ࡁࡿᩘ㔞ࡣୖグࡢ 1/10 ࢆ㝈ᗘ࡜ࡋෆᩘ
࡜ࡍࡿࠋࡲࡓࠊ14C ࡜ 35S ࡢ 3 ᭶㛫౑⏝ᩘ㔞ࡣୖグࡢ 1/20 ࡜ࡋෆᩘ࡜ࡍࡿࠋ



4. ฼⏝⪅㈇ᢸ㔠ᩱ㔠⾲
Ⓩ㘓ᩱ➼
㡯┠

༢఩

༢౯(෇)

ಶேⓏ㘓ᩱ

ಶே࣭ᖺ

2,500

࢞ࣛࢫࣂࢵࢪ FS ᆺ

ே࣭᭶

400

࢞ࣛࢫࣂࢵࢪ NS ᆺ

ே࣭᭶

1,800

ᐇ㦂ᐊ౑⏝ᩱ

ศ㔝➼࣭᭶

7,000

ື≀ᐇ㦂ᐊ౑⏝ᩱ

ศ㔝➼࣭᪥

1,000

᫬㛫እ౑⏝ᩱ(ᖹ᪥)

ே࣭᪥

500

᫬㛫እ౑⏝ᩱ(ᅵ࣭᪥࣭⚍᪥)

ே࣭᪥

1,000

ᶵჾ౑⏝ᩱ
ྡ⛠

タ⨨ሙᡤ

ᾮయࢩࣥࢳ࣮ࣞࢩࣙࣥ
࢝࢘ࣥࢱ࣮࣓࣮࣮࢝ࠊᆺ␒

RI ◊✲Ჷ

ࣃࢵ࣮࢝ࢻ㸪Tri-Carb2900TR

RI ◊✲Ჷ

࢔ࣟ࢝㸪LSC-6100

ࢤࣀ࣒ RI ᐇ㦂ᐊ࢔ࣟ࢝㸪LSC-7200

༢఩

༢౯(෇)

ࢧࣥࣉࣝ

25

ࣉ࣮ࣞࢺ࢝࢘ࣥࢱ࣮

RI ◊✲Ჷ

ࣃ࣮࢚࣐࣮࢟ࣥࣝ㸪
1450 MicroBeta TRILUX

ࣉ࣮ࣞࢺ

500

ࢭࣝࣁ࣮࣋ࢫࢱ࣮

RI ◊✲Ჷ

ࣃ࣮࢚࣐࣮࢟ࣥࣝ㸪FilterMate-96

ࣉ࣮ࣞࢺ

1,500

RI ◊✲Ჷ

ࣃ࣮࢚࣐࣮࢟ࣥࣝ㸪1480 WIZARD3
ࢧࣥࣉࣝ

25

ศ

50

᫬㛫

250

J࢝࢘ࣥࢱ࣮

ࢤࣀ࣒ RI ᐇ㦂ᐊࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ
࢔ࢼࣛ࢖ࢨ࣮
Ge ༙ᑟయ᳨ฟჾ

࢔ࣟ࢝㸪ARC-7001

RI ◊✲Ჷ

ᐩኈࣇ࢕࣒ࣝ㸪BAS̺2500

RI ◊✲ᲷSEIKO EG&G ORTEC㸪GEM20/MCA7700

ࢤࣀ࣒ RI ᐇ㦂ᐊ

SEIKO EG&G ORTEC㸪GEM25/MCA7

ト㸧฼⏝⪅ࡀᨾពࡲࡓࡣ㐣ኻ࡟ࡼࡗ࡚ RI ᐇ㦂ศ㔝ࡢ⿦⨨ཬࡧタഛ➼࡟ᦆᐖࢆ୚࠼ࡓሙྜࡣࠊㄢ㢟㈐௵⪅ࢆ㏻ࡋ࡚ࡑࡢᦆᐖࡢ඲㒊ཪࡣ୍㒊ࢆ㈺ൾࡉࡏࡿࡶࡢ࡜ࡍࡿࠋ

ᗫᲠ≀ᩱ㔠
✀㢮

༢఩

༢౯(෇)

ື≀ฎ⌮㈝

kg

2,000

ᅛయᗫᲠ≀(ྍ⇞࣭㞴⇞࣭୙⇞➼)

⿄

2,000

ࢩࣥࢳ࣮ࣞࢱᗫᾮ

ࣜࢵࢺࣝ

5,000

↓ᶵᗫᾮ

ࣜࢵࢺࣝ

1,800



4 άືሗ࿌
1. ௧࿴3 ᖺᗘᩍ⫱カ⦎ཷㅮ⪅ᩘ≉Ṧ೺ᗣデ᩿㸦㟁㞳㸧ཷデ⪅ᩘ࣭ᩍ⫱カ⦎ཷㅮ⪅ᩘ᪂ᆺࢥࣟࢼ࡟క࠸ࠊ௚஦ᴗᡤ e-leaning ࡶే⏝ࡋࡓࠋ
ᐇ᪋᪥

༊ศ

ෆᐜ

ேᩘ

ᐇ᪋ᶵ㛵㸦ㅮᖌ㸧

2021/5/6

᪂つㅮ⩏

ே 30ࠊᏳ 60ࠊἲண 303ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦≟ሯ㸧

2021/5/6

᪂つ

ᐇ⩦

Ᏻ 90

3

ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦୕㍯㸧

2021/5/18㹼6/8⥅⥆

e-learningே 15ࠊᏳ 15ࠊἲண 30ࠊㄢ㢟

93ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦ᮌෆࠊ≟ሯ㸧

2021/6/14㹼16

᪂つe-learningே 40ࠊᏳ 180ࠊἲண 40

31ྡྂᒇ኱Ꮫ࢔࢖ࢯࢺ࣮ࣉ⥲ྜࢭࣥࢱ࣮

2021/6/14㹼16

᪂つe-learningே 40ࠊᏳ 120ࠊἲண 40

20ྡྂᒇ኱Ꮫ࢔࢖ࢯࢺ࣮ࣉ⥲ྜࢭࣥࢱ࣮

2021/6/24⥅⥆

e-learningே 15ࠊᏳ 15ࠊἲண 30ࠊㄢ㢟

1ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦ᮌෆࠊ≟ሯ㸧

2021/7/6㹼8

᪂つe-learningே 40ࠊᏳ 120ࠊἲண 401ྡྂᒇ኱Ꮫ࢔࢖ࢯࢺ࣮ࣉ⥲ྜࢭࣥࢱ࣮

2021/7/9

᪂つᐇ⩦

ண 30ࠊᏳ 602ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦≟ሯࠊ୕㍯㸧

2021/7/19

᪂つᐇ⩦ண 30ࠊᏳ 604ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦≟ሯࠊ୕㍯㸧

2021/9/9

᪂つᐇ⩦

ண 30ࠊᏳ 601ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦୕㍯㸧

2021/10/13㹼15

᪂つe-learningே 40ࠊᏳ 180ࠊἲண 40

3ྡྂᒇ኱Ꮫ࢔࢖ࢯࢺ࣮ࣉ⥲ྜࢭࣥࢱ࣮

2021/10/21

᪂つᐇ⩦

ண 30ࠊᏳ 601ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦୕㍯㸧

2021/11/1

᪂つㅮ⩏

ே 30ࠊᏳ 60ࠊἲண 303ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦≟ሯ㸧

2021/11/30

᪂つㅮ⩏

ே 30ࠊᏳ 60ࠊἲண 301ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦≟ሯ㸧

2022/1/12

᪂つ

ᐇ⩦

Ᏻ 90

3

ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦୕㍯㸧

2022/1/28

᪂つㅮ⩏ே 30ࠊᏳ 60ࠊἲண 301ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦≟ሯ㸧

2022/1/28

᪂つ

ᐇ⩦

Ᏻ 90

1

ᒱ㜧኱Ꮫ RI ᐇ㦂ศ㔝㸦୕㍯㸧ே㸸ᨺᑕ⥺ࡢேయ࡟୚࠼ࡿᙳ㡪Ᏻ㸸ᨺᑕᛶྠ఩ඖ⣲➼ཪࡣᨺᑕ⥺Ⓨ⏕⿦⨨ࡢᏳ඲ྲྀᢅ࠸
ἲண㸸ᨺᑕ⥺㞀ᐖࡢ㜵Ṇ࡟㛵ࡍࡿἲ௧ཬࡧᨺᑕ⥺㞀ᐖண㜵つ⛬ᩘᏐࡣࠊྛ㡯┠ෆᐜࡢ᫬㛫ᩘ㸦ศ㸧ㄢ㢟㸸ᑠࢸࢫࢺࢆᐇ᪋

࣭≉Ṧ೺ᗣデ᩿(㟁㞳)ཷデ⪅ᩘ
㌟ศ

๓ᮇ

ᚋᮇ

⫋ဨ➼

43

42

Ꮫ⏕➼

106

4



2. ௧࿴ 3 ᖺᗘ᪋タ฼⏝≧ἣᏛ㒊ูⓏ㘓⪅ᩘ 㸨ᩍ⫱Ꮫ㒊࣭◊✲⛉ࡢᏛෆእ᪋タ฼⏝Ⓩ㘓⪅ 8 ྡ㒊ᒁ࣭኱Ꮫྡ➼

Ꮫෆ᪋タ

Ꮫእ᪋タ

ᩍ⫱Ꮫ㒊࣭◊✲⛉ 㸨

8

25

་Ꮫ◊✲⛉

8

0

ᕤᏛ㒊࣭◊✲⛉

1868ᛂ⏝⏕≀⛉Ꮫ㒊࣭◊✲⛉

18

20⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮

40ᒱ㜧⸆⛉኱Ꮫ

10

ࡑࡢ௚(ཷク)

3

0

52

105

ྜ ィ

ᨺᑕ⥺ᴗົᚑ஦⪅ᩘ 㸨ࡇࡢෆࠊᏛෆእᨺᑕ⥺ᴗົᚑ஦⪅ 2 ྡ
Ꮫෆ᪋タ

Ꮫእ᪋タ

26

50

Ꮫෆ⟶⌮༊ᇦ࡬ࡢᘏ࡭❧ධ௳ᩘཬࡧᘏ࡭❧ධ᫬㛫ᘏ࡭❧ධ௳ᩘ

ᘏ࡭❧ධ᫬㛫

RI ◊✲Ჷ

1970

906

ࢤࣀ࣒◊✲Ჷ RI ᐇ㦂ᐊ

122

13

ேᩘ

ᘏ࡭ᅇᩘ

SPring-82656㧗࢚ࢿࣝࢠ࣮ຍ㏿ჾ◊✲ᶵᵓ

1017࠶࠸ࡕࢩࣥࢡࢺࣟࣥගࢭࣥࢱ࣮

720

ศᏊ⛉Ꮫ◊✲ᡤ

415ᅜ❧㛗ᑑ་⒪◊✲ࢭࣥࢱ࣮

2

24

භࢣᡤ᰾⼥ྜ◊✲ᡤ11

ࢻ࢖ࢶ 㔜࢖࢜ࣥ◊✲ᡤ(GSI)

1

4

⟶⌮༊ᇦ

Ꮫእ᪋タ฼⏝ேᩘཬࡧᘏ࡭฼⏝ᅇᩘ฼⏝ሙᡤྛᨺᑕ⥺ ᐃჾ➼ࡢ฼⏝ᐇ⦼ 㸨ཷクヨ㦂ศࡣ㝖ࡃ
ᶵჾ

ᆺ␒

฼⏝ᐇ⦼

ᾮయࢩࣥࢳ࣮ࣞࢩࣙࣥ࢝࢘ࣥࢱ࣮

ࣃࢵ࣮࢝ࢻ㸪Tri-Carb2900TR

388 ᮏࣉ࣮ࣞࢺ࢝࢘ࣥࢱ࣮

ࣃ࣮࢚࣐࣮࢟ࣥࣝ㸪1450 MicroBeta TRILUX

9ᯛ

Ge ༙ᑟయ᳨ฟჾSEIKO EG&G ORTEC㸪GEM20/MCA7700

1090 ᫬㛫ཷクヨ㦂➼౫㢗ᐇ⦼௳ᩘ࣭ᮇ㛫

1 ௳࣭2021/5㹼2022/2౑⏝ᶵჾᾮయࢩࣥࢳ࣮ࣞࢩࣙࣥ࢝࢘ࣥࢱ࣮ࠊ࣐࢖ࢡࣟࣉ࣮ࣞࢺ࣮ࣜࢲ࣮ࠊࢭࣝࣁ࣮࣋ࢫࢱ࣮

6

3. ᨺᑕ⥺ᴗົᚑ஦⪅ࡢᴗ⦼ㄽᩥ➼㸦2021 ᖺ㸧ཎⴭㄽᩥ
1. Isogawa, K.; Asano, M.; Hyazaki, M.; Koga, K.; Watanabe, M.; Suzuki, K.; Kobayashi, T.; Kawaguchi, K.;
Ishizuka, A.; Kato, S.; Ito, H.; Hamamoto, A.; Koyama, H.; Furuta, K.; Takemori, H. Thioxothiazolidin Derivative,
4-OST, Inhibits Melanogenesis by Enhancing the Specific Recruitment of Tyrosinase-containing Vesicles to
Lysosome, J. Cell. Biol. , 122, 1-12.

4. ᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝ᩍဨࡢᩍ⫱࣭◊✲άື➼1㸧ᩍ⫱άື
᭷ᶵ໬Ꮫ IIa㸦ࢥ࣮ࢫ⛉┠ࠊᑐ㇟Ꮫ⏕㸸≀㉁໬Ꮫࢥ࣮ࢫࠊ2 ༢఩㸧㸦≟ሯ㸧≀㉁໬Ꮫᐇ㦂 II㸦ࢥ࣮ࢫ⛉┠ࠊᑐ㇟Ꮫ⏕㸸≀㉁໬Ꮫࢥ࣮ࢫࠊ3 ༢఩㸧㸦≟ሯ㸧ᇶ♏໬Ꮫᐇ㦂㸦Ꮫ⛉ඹ㏻⛉┠ࠊᑐ㇟Ꮫ⏕㸸໬Ꮫ࣭⏕࿨ᕤᏛ⛉ࠊ2 ༢఩㸧㸦≟ሯ㸧ᕤᏛᇶ♏ᐇ㦂㸦ᇶ♏⛉┠ࠊᑐ㇟Ꮫ⏕㸸ᕤᏛ㒊ࠊ1 ༢఩㸧㸦≟ሯ㸧༞ᴗ◊✲㸦Ꮫ⛉ඹ㏻⛉┠ࠊᑐ㇟Ꮫ⏕㸸໬Ꮫ࣭⏕࿨ᕤᏛ⛉ࠊ8 ༢఩㸧㸦≟ሯ㸧᭷ᶵྜᡂ໬Ꮫ≉ㄽ㸦ᑓ㛛⛉┠ࠊᑐ㇟Ꮫ⏕㸸⮬↛⛉Ꮫᢏ⾡◊✲⛉ࠊ1 ༢఩㸧㸦≟ሯ㸧
2㸧◊✲άື
ࠑཎⴭㄽᩥ࣭ⴭ᭩➼ࠒ
1. Kubota, Y.; Nakazawa, M.; Lee, J.; Naoi, R.; Tachikawa, M.; Inuzuka, T.; Funabiki, K.; Matsui, M.; Kim, T.
Synthesis of near-infrared absorbing and fluorescent bis(pyrrol-2-yl)squaraines and their halochromic properties,
Organic Chemistry Frontiers 2021, 8, 6226-6243.
2. Izawa, S.; Uchida, K.; Nakamura, M.; Fujimoto, K.; Roudin, J.; Lee, J.-H.; Inuzuka, T.; Nakamura, T.; Sakamoto,M.; Nakayama, Y.; Hiramoto, M.; Takahashi, M. Influence of N-substituents on photovoltaic properties of singly
bay-linked dimeric perylene diimides, Chemistry A European Journal 2021, 27, 14081-14091.
3. Sengoku, T.; Ogawa, D.; Iwama, H.; Inuzuka, T.; Yoda, H. A heavy-metal-free desulfonylative Giese-type reactionof benzothiazole sulfones under visible-light conditions, Chemical Communications 2021, 57, 9858-9861.
4. Fujimoto, K.; Takimoto, S.; Masuda, S.; Inuzuka, T.; Sanada, K.; Sakamoto, M.; Takahashi, M. 5,11Diazadibenzo[hi,qr]tetracene: synthesis, properties, and reactivity toward nucleophilic reagents, Chemistry A
European Journal 2021, 27, 8951-8955.
5. Kawazoe, Y.; Itakura, Y.; Inuzuka, T.; Omura, S.; Uemura, D. Structure–activity relationship study of the antiဨ
obesity natural product yoshinone A Chirality, , 1-7.
6. Funabiki, K.; Yamada, K.; Matsueda, H.; Arisawa, Y.; Agou, T.; Kubota, Y.; Inuzuka, T.; Wasada, H.
Perfluorophenyl-perfluorophenyl stacking-promoted aggregation-induced emission enhancement of crystalline 5aryloxy-3H-indole European Journal of Organic Chemistry, , 1344-1350.
7. Fujimoto, K.; Izawa, S.; Takahashi, A.; Inuzuka, T.; Sanada, K.; Sakamoto, M. Nakayama, Y.; Hiramoto, M.;
Takahashi, M. Curved perylene diimides fused with sven-membered rings Chemistry An Asian Journal , 16,
690-695.

7

8. Funabiki, K.; Gotoh, T.; Kani, R.; Inuzuka, T.; Kubota, Y. Highly diastereo- and enantioselective organocatalytic
synthesis of trifluoromethylated erythritols based on the in situ generation of unstable trifluoroacetaldehyde, Organic
and Biomolecular Chemistry , 19, 1296-1304.
9. Uemura, D.; Kawazoe, Y.; Inuzuka, T.; Itakura, Y.; Kawamata, C.; Abe, T. Drug leads derived from Japanesemarine organisms, Current Medicinal Chemistry 2021, 28, 196-210.
ࠑᏛ఍Ⓨ⾲ࠒ
1. ୖᶫ⿱㍤࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭࿃㒓཭ᏹ࣭⯪᭥୍ṇ㸪ྵࣇࢵ⣲」⣲⎔ࡲࡓࡣྵࣇࢵ⣲ᑐ࢔ࢽ࢜ࣥࢆ
᭷ࡍࡿࢫࢡ࢔࣒ࣜࣜ࢘Ⰽ⣲ࡢඃࢀࡓ⪏ගᛶ㸪➨ 44 ᅇࣇࢵ⣲໬Ꮫウㄽ఍㸪2021 ᖺ 11 ᭶
2. ྍඣ㱟அ௓࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪➨୍⣭࢔࣑ࣥ࡟ᛂ⟅ࡍࡿⰾ㤶⎔ࣇࢵ⣲໬Ⰽ⣲ࡢ⁐፹౫Ꮡⓗ࡞࣓࢝ࣛࣜࢺࣜࢵࢡ≉ᛶ㸪➨ 44 ᅇࣇࢵ⣲໬Ꮫウㄽ఍㸪2021 ᖺ 11 ᭶
3. ᭷⃝♸ኴ࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪᪂つ࡞࢔ࢽ࢜ࣥᛶ࣊ࣉࢱ࣓ࢳࣥࢩ࢔ࢽࣥⰍ⣲ࡢ㛤Ⓨ࡜ࡑࡢ≉ᛶ㸪➨ 52 ᅇ ୰㒊໬Ꮫ㛵ಀᏛ༠఍ᨭ㒊㐃ྜ⛅Ꮨ኱఍㸪2021 ᖺ 10 ᭶
4. ୖᶫ⿱㍤࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭࿃㒓཭ᏹ࣭⯪᭥୍ṇ㸪ྵࣇࢵ⣲ᑐ࢔ࢽ࢜ࣥࡢ᭷↓࡟ࡼࡿࢫࢡ࢔ࣜࣜ
࣒࢘Ⰽ⣲ࡢ≉ᛶኚ໬㸪➨ 52 ᅇ ୰㒊໬Ꮫ㛵ಀᏛ༠఍ᨭ㒊㐃ྜ⛅Ꮨ኱఍㸪2021 ᖺ 10 ᭶
5. ୰⃝ㄔே࣭┤஭Ⰻ☻࣭≟ሯಇᗣ࣭⯪᭥୍ṇ࣭❑⏣⿱኱㸪㏆㉥እ㡿ᇦ࡟྾཰ࢆ᭷ࡍࡿࢫࢡ࢔࣒ࣜࣜ࢘Ⰽ
⣲࠾ࡼࡧࢡࣟࢥࢽ࣒࢘Ⰽ⣲ࡢྜᡂ㸪➨ 52 ᅇ ୰㒊໬Ꮫ㛵ಀᏛ༠఍ᨭ㒊㐃ྜ⛅Ꮨ኱఍㸪2021 ᖺ 10 ᭶
6. ≟ሯಇᗣ࣭኱἟Ⳁ⥴࣭ୖᮧ኱㍜㸪㧗▱┴⏘࢝࢖࣓ࣥ⏤᮶⣽⬊ẘᛶ≀㉁ࢫࢡࣔࣛ࢖ࢻ㢮ࡢ༢㞳࣭ᵓ㐀ゎᯒ㸪➨ 63 ᅇኳ↛᭷ᶵ໬ྜ≀ウㄽ఍㸪2021 ᖺ 9 ᭶
7. ᭷⃝♸ኴ࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪ࣇࢵ⣲໬࢔ࢽ࢜ࣥᛶ࣊ࣉࢱ࣓ࢳࣥࢩ࢔ࢽࣥⰍ⣲ྵ᭷」ྜ
ᮦᩱࡢ㓟࡟ᑐࡍࡿࢭࣥࢧ࣮≉ᛶ㸪➨ 10 ᅇࣇࢵ⣲໬Ꮫⱝᡭࡢ఍㸪2021 ᖺ 9 ᭶
8. ୰⃝ㄔே࣭┤஭Ⰻ☻࣭≟ሯಇᗣ࣭⯪᭥୍ṇ࣭❑⏣⿱኱㸪ࣆ࣮ࣟࣝࢆẕయ࡜ࡋࡓࢫࢡ࢔࣒ࣜࣜ࢘Ⰽ⣲࠾ࡼࡧࢡࣟࢥࢽ࣒࢘Ⰽ⣲ࡢྜᡂ࡜ගᏛ≉ᛶ㸪2021 ᖺᗘⰍᮦ◊✲Ⓨ⾲఍㸪2021 ᖺ 9 ᭶
9. ᒣᮏၨ㝧࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪㏆㉥እ㡿ᇦ࡟྾཰࣭⺯ගࢆᣢࡘࣉࢵࢩࣗ-ࣉࣝᆺⰍ⣲ࡢ㛤
Ⓨ㸪2021 ᖺᗘⰍᮦ◊✲Ⓨ⾲఍ 㸪2021 ᖺ 9 ᭶
10. ୖᶫ⿱㍤࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪ⰾ㤶⎔ࣇࢵ⣲໬࢖ࣥࢻࣞࢽࣥ⎔ࢆ᭷ࡍࡿࢫࢡ࢔࣒ࣜࣜ࢘
Ⰽ⣲ࡢගᏛ≉ᛶ㸪2021 ᖺᗘⰍᮦ◊✲Ⓨ⾲఍㸪2021 ᖺ 9 ᭶
11. ᭷⃝♸ኴ࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪࢔ࢽ࢜ࣥᛶ࣊ࣉࢱ࣓ࢳࣥࢩ࢔ࢽࣥⰍ⣲ࢆ྾╔ࡉࡏࡓ↓ᶵᮦᩱࡢ㓟ᛂ⟅ᛶ㸪2021 ᖺᗘⰍᮦ◊✲Ⓨ⾲఍㸪2021 ᖺ 9 ᭶
12. ྍඣ㱟அ௓࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪ࢢࣜࢽ࣮ࣕࣝ཯ᛂ๣ࡢࢹࣗ࢔ࣝ࡞཯ᛂࢆ one-pot ฼⏝ࡋࡓ 1-ࢺࣜࣇ࣓ࣝ࢜ࣟࢳࣝࣉࣟࣃࣝࢠࣝ࢔ࣝࢥ࣮ࣝ㢮ࡢ⡆౽ྜᡂ㸪2021 ᖺᗘ᭷ᶵྜᡂ໬Ꮫ໭㝣ࢭ࣑ࢼ࣮㸪2021 ᖺ 9 ᭶
13. ୖᶫ⿱㍤࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪ⰾ㤶᪘ࣇࢵ⣲໬」⣲⎔ࢆ᭷ࡍࡿ᪂つ NIR Ⰽ⣲ࡢྜᡂ࡜ࡑࡢ≉ᛶ㸪᪥ᮏ໬Ꮫ఍➨ 101 ᫓Ꮨᖺ఍㸪2021 ᖺ 3 ᭶
14. ᭷⃝♸ኴ࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪࢔ࢽ࢜ࣥᛶ࣊ࣉࢱ࣓ࢳࣥࢩ࢔ࢽࣥⰍ⣲ࡢ≉ᛶ࡟࠾ࡅࡿ⨨᥮ᇶࡢຠᯝ㸪᪥ᮏ໬Ꮫ఍➨ 101 ᫓Ꮨᖺ఍㸪2021 ᖺ 3 ᭶
15. ྍඣ㱟அ௓࣭≟ሯಇᗣ࣭❑⏣⿱኱࣭⯪᭥୍ṇ㸪ྛ✀⨨᥮ᇶࢆ᭷ࡍࡿྵࣇࢵ⣲ 1,4-ࢪࣄࢻࣟ-2H-࣋ࣥࢰ
[d][1,3]࢜࢟ࢧࢪࣥ-2-࢜ࣥ㢮ࡢ⡆౽ྜᡂ㸪᪥ᮏ໬Ꮫ఍➨ 101 ᫓Ꮨᖺ఍㸪2021 ᖺ 3 ᭶
16. ⚄㇂⣪ᕼ࣭❑⏣⿱኱࣭≟ሯಇᗣ࣭⯪᭥୍ṇ㸪ྛ✀⁐፹୰࡛ࡢⰾ㤶⎔ࣇࢵ⣲໬࣌ࣥࢱ࣓ࢳࣥࢩ࢔ࢽࣥⰍ

⣲ࡢ≉ᛶ㸪᪥ᮏ໬Ꮫ఍➨ 101 ᫓Ꮨᖺ఍㸪2021 ᖺ 3 ᭶
17. ୰⃝ㄔே࣭≟ሯಇᗣ࣭⯪᭥୍ṇ࣭❑⏣⿱኱㸪㏆㉥እ㡿ᇦ࡟྾཰ࢆ᭷ࡍࡿࢡࣟࢥࢽ࣒࢘Ⰽ⣲ࡢྜᡂ࡜ග
Ꮫ≉ᛶ㸪᪥ᮏ໬Ꮫ఍➨ 101 ᫓Ꮨᖺ఍㸪2021 ᖺ 3 ᭶3㸧⿵ຓ㔠㛵㐃᥇ᢥ≧ἣࢩ࣮ࢩ࣮࢔࢖◊✲ຓᡂࣉࣟࢢ࣒ࣛ㸪௧࿴ 3 ᖺᗘ㠴ẟ⸴ Symbiodinium sp. ࡀ⏕⏘ࡍࡿ≉␗࡞ᵓ㐀ࢆࡶࡘᶵ⬟ᛶ≀㉁ࡢ᥈⣴┤᥋⤒㈝:1,000,000 ෇㸦≟ሯ㸧㉺ᒣ⛉Ꮫᢏ⾡᣺⯆㈈ᅋ◊✲ຓᡂ㸪௧࿴ 2 ᖺᗘ-௧࿴ 3 ᖺᗘᢠ⭘⒆స⏝ࢆ♧ࡍ᪂つ໬ྜ≀ࢫࢡࣔࢽࣥࡢ฼ά⏝࡟ྥࡅࡓ඲ྜᡂ◊✲┤᥋⤒㈝:1,000,000 ෇ (⥲㢠)㸦≟ሯ㸧ᢠ㓟໬◊✲㒊㛛'LYLVLRQRIDQWL2[LGDQW5HVHDUFK
ࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : info@antioxidantres.jp
TEL : 058-230-6548
FAX : 058-230-6549

┠ḟ‫ ی‬㒊㛛㛗࠶࠸ࡉࡘ ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭  ⤌⧊ ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ 㸦㸧ᑓ௵ᩍဨ
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㸯㸬⤌⧊
≉௵ᩍᤵ

≟ᡣ

᫓ᙪ

≉௵ຓᩍ

᳿

㤼⳹

≉௵ຓᩍ

ᒸ⏣

┤⨾

◊✲ဨ

ཎᕝ

⩏ဴ

㸰㸬ᩍဨࡢ◊✲άື࠙Ꮫ఍ࠚ㸦ᅜෆᏛ఍㸧
1. ≟ᡣ᫓ᙪ. ࢚ࣅࢹࣥࢫ๰ฟጤဨ఍ሗ࿌

Twendee X ࡢᢠ㓟໬స⏝࡟ࡼࡿㄆ▱⑕ண㜵ຠᯝ. ➨ 10 ᅇ᪥ᮏㄆ▱⑕ண㜵Ꮫ఍Ꮫ⾡㞟఍, ᶓ὾, 2021 ᖺ 6 ᭶.
2. ᳿㤼⳹, ≟ᡣ᫓ᙪ. ᢠ㓟໬㓄ྜ๣ Twendee X ࡢ㓟໬ࢫࢺࣞࢫ⑓࡬ࡢᨵၿ࡜
⭠ෆ⣽⳦ྀ࡜ࡢ㛵ࢃࡾ. ➨ 10 ᅇ᪥ᮏㄆ▱⑕ண㜵Ꮫ఍Ꮫ⾡㞟఍, ᶓ὾, 2021
ᖺ 6 ᭶.
3. ≟ᡣ᫓ᙪ. ㄆ▱⑕ண㜵ࡢ᭱ඛ➃

Twendee X ࡢᢠ㓟໬స⏝࡟ࡼࡿㄆ▱⑕ண㜵ຠᯝ. ➨ 10 ᅇ᪥ᮏㄆ▱⑕ண㜵Ꮫ఍Ꮫ⾡㞟఍, ᶓ὾, 2021 ᖺ 6 ᭶.
4. ᒸ⏣┤⨾. ࡀࢇ἞⒪࡟࠾ࡅࡿᢠ㓟໬๣ࡢᙺ๭㸸㢌㢁㒊ࡢ⒴࡞ࡢ࡟⭠ࡢ⣽⳦ྀࡀ኱஦࡞ࡢ㸽 ᪥ᮏᢠຍ㱋་Ꮫ఍Ꮫ⾡㞟఍, ி㒔, 2021 ᖺ 6 ᭶.
5. ≟ᡣ᫓ᙪ. ᪥ᮏㄆ▱⑕ண㜵Ꮫ఍࣭࢚ࣅࢹࣥࢫ A ㄆᐃࢧࣉ࣓ࣜࣥࢺ㸸Twendee
X ࡜ࣛࢡࢺࣜࣥウㄽ. ➨ 3 ᅇ᪥ᮏ⬻ࢧࣉ࣓ࣜࣥࢺᏛ఍, ᮾி, 2021 ᖺ 10 ᭶.
6. ᒸ⏣┤⨾. 㐍Ṍⴭࡋ࠸ࡀࢇ἞⒪㸸⬻ࢧࣉ࣓ࣜࣥࢺ࡜ᢠࡀࢇస⏝ 㹼ᢠ㓟໬๣
TwendeeX ࢆ஦౛࡜ࡋ࡚㹼. ➨ 3 ᅇ᪥ᮏ⬻ࢧࣉ࣓ࣜࣥࢺᏛ఍, ᮾி, 2021 ᖺ
10 ᭶.
࠙㞧ㄅᐤ✏࣭ㄽᩥࠚ
㸦࿴ᩥⴭ᭩㸧
1. ᳿㤼⳹, ⏣୰⩧, ࣐࣮࢝ࢫ࣭࣐ࢳ࣮ࣗࢩ࣭࢝ࢢࣛࣇ࢙ࣥࢡࣛ࢘, ྜྷᕝᩄ୍, ᒸ⏣┤⨾, ≟ᡣ᫓ᙪ.

ᢠ㓟໬๣ Twendee X ࡀ㧗㱋⪅἞⒪࡟ᣮࡴ ̿ୡ⏺ึࡢㄆ▱⑕ண㜵ࡢᐇ⌧࠿ࡽぢࡿ௒ᚋࡢண㜵἞⒪̿. Precision Medicine ➨ 4 ᕳ➨ 5 ྕ, 2021 ᖺ 5 ᭶ 25 ᪥Ⓨ⾜.



2. ≟ᡣ᫓ᙪ. Ꮫ఍࣏࣮ࣞࢺ ➨ 3 ᅇ᪥ᮏ⬻ࢧࣉ࣓ࣜࣥࢺᏛ఍. ་࡜㣗 Vol. 13,
No.6, 2021 ᖺ 12 ᭶Ⓨ⾜.
3. ᳿㤼⳹, ཎᕝ⩏ဴ, ᖹ㔝⁠, ྜྷᕝᩄ୍, ≟ᡣ᫓ᙪ. 㧗㱋⪅་⒪࡟࠾ࡅࡿᢠ㓟໬ࢧࣉ࣓ࣜࣥࢺࡢᙺ๭. ⪁ᖺ⛉ ➨ 5 ᕳ➨ 1 ྕ, 2022 ᖺ 1 ᭶Ⓨ⾜.
࠙ᩍ⫱ࠊࢭ࣑ࢼ࣮➼ࠚ
1. ≟ᡣ᫓ᙪ. ᪂ᆺࢥࣟࢼឤᰁ⑕ࡣ㓟໬ࢫࢺࣞࢫ⑓

㓟໬ࢫࢺࣞࢫࡗ࡚ఱ㸽 ୰᪥ᩥ໬ࢭࣥࢱ࣮, ྡྂᒇ, 2021 ᖺ 4 ᭶.
2. ≟ᡣ᫓ᙪ. ⢾ᒀ⑓ࠊㄆ▱⑕ࠊ㧗⾑ᅽࡶ㓟໬ࢫࢺࣞࢫ⑓

㣗⏕ά࡛ண㜵࡛ࡁࡿࡢ࠿㸽 ୰᪥ᩥ໬ࢭࣥࢱ࣮, ྡྂᒇ, 2021 ᖺ 5 ᭶.
3. ≟ᡣ᫓ᙪ. ᑑ࿨ࢆ⦰ࡵࡿࡀࢇࡶண㜵࡛ࡁࡿࡢ࠿㸽 ୰᪥ᩥ໬ࢭࣥࢱ࣮, ྡྂᒇ,2021 ᖺ 6 ᭶.

㸱㸬Ꮫእ࡛ࡢඹྠ◊✲⪅බ┈㈈ᅋἲேࣝ࢖࣭ࣃࢫࢺ࣮ࢗࣝ་Ꮫ◊✲ᡤி㒔ᗓ❧་⛉኱Ꮫ⪥㰯ဗႃ⛉࣭㢌㢕㒊እ⛉ᩍᐊᗈᓥ኱Ꮫ኱Ꮫ㝔ศᏊෆ⛉Ꮫ

୰ᓥ

ྜྷᕝ

ᩄ୍⌮஦㛗

ᖹ㔝

⁠ᩍᤵ

ᣅඛ⏕

Ⱚᾆᕤᴗ኱Ꮫࢩࢫࢸ࣒⌮ᕤᏛ㒊⏕࿨⛉Ꮫ⛉⏕⌮໬Ꮫᩍᐊࣇࣛࣥࢫ⛉Ꮫ࢔࢝ࢹ࣑࣮

⚟஭

ᾈ஧ᩍᤵ

ࢡࣜࢫࢳࣕࣥ㺃࢔࣐ࢺ࣮ࣞᩍᤵ

࣮ࣞࢤࣥࢫࣈࣝࢢ኱Ꮫ㸦ࢻ࢖ࢶ㸧࣒࣮࣊ࣝࢺ㺃ࢹࣗࣝࢩ࣮ࣗࣛࢢ༤ኈ

LYSANDO㸦ࢻ࢖ࢶ࣭࣮ࣞࢤࣥࢫࣈࣝࢡ㸧
ICDD (ࣇࣛࣥࢫ࣭ࢪ࢙࣓ࣀࢫ)ࢧ࢖࢔࣒ࢭ࣓ࣥࢺࢢ࣮ࣝࣉ㸦SCG ࢱ࢖࣭ࣂࣥࢥࢡ㸧

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ࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : mgrc@gifu-u.ac.jp
TEL : 058-293-3171
FAX : 058-293-3172

┠‫ ی‬㧗➼◊✲㝔㑇ఏᏊ᳨ᰝᐊ㛗ᣵᣜḟ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㑇ఏᏊ᳨ᰝᐊ
ᒱ㜧኱Ꮫ≉௵ᩍᤵ࣭ྡ㄃ᩍᤵࠊⓏ㘓⾨⏕᳨ᰝᡤᒱ㜧኱Ꮫ㧗➼◊✲㝔㑇ఏᏊ᳨ᰝᐊ⟶⌮⪅୍⯡♫ᅋἲேᮾᾏ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ᥎㐍༠఍⌮஦㛗ୗ⃝ఙ⾜ᒱ㜧኱Ꮫ㧗➼◊✲㝔䛸་Ꮫ㒊㝃ᒓ⑓㝔䛾䛤ᨭ᥼䛻䛶䝀䝜䝮◊✲Ჷෆ䛻㧗➼◊✲㝔㑇ఏᏊ᳨ᰝᐊ䜢タ⨨䛧䚸2021 ᖺ 3 ᭶ 1 ᪥௜䛷⾨⏕᳨ᰝᡤ䛻Ⓩ㘓䛜ㄆྍ䛥䜜䚸4 ᭶ 1 ᪥䜘䜚඲ᅜ་⒪ᶵ㛵䛻ᑐ䛧䛶䚸ᣦᐃ㞴⑓䛂๪⭈ⓑ㉁䝆䝇䝖䝻䝣䜱䞊䠄ALD䠅䛃䛾㑇ఏᏛⓗ᳨ᰝ䛾ಖ㝤デ⒪䛻䜘䜛ཷクゎᯒ䜢⾜䛺䛳䛶䛔䜎䛩䚹䛭䜜䛻క䛔௧࿴ 3 ᖺᗘ䜘䜚㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊⤌⧊ෆ䛻㑇ఏᏊ᳨ᰝᐊ䜢タ⨨䛧䛶䛔䜎䛩䚹ᮏᏛ䛷䛿㛗ᖺ䛻䜟䛯䜚 ALD 䛸䝨䝹䜸䜻䝅䝋䞊䝮⑓䛾ᅜෆデ᩿ᣐⅬ䛸䛧䛶ᶵ⬟䛧䛶䛝䜎䛧䛯䛜䚸◊✲ᡂᯝ䛾♫఍ᐇ⿦䜢┠ⓗ䛻 2019 ᖺ 7 ᭶䛻་Ꮫ㒊㝃ᒓ⑓㝔᳨ᰝ㒊䛻㞴⑓᳨ᰝ㒊㛛䜢᪂タ䛧䝀䝜䝮◊✲Ჷෆ䛻㞴⑓᳨ᰝᐊ䜢タ⨨䚸䛥䜙䛻௒ᅇ䛾㑇ఏᏊ᳨ᰝᐊ䛾タ⨨䛻䜘䜛♫఍ᐇ⿦䛻⧅䛢䛶䛔䜎䛩䚹ᒱ㜧┴䛷䛿 2021 ᖺᗘ䜘䜚୍⯡♫ᅋἲேᮾᾏ䝬䝇䝇䜽䝸䞊䝙䞁䜾᥎㐍༠఍䛜୺ᑟ䛧䛶┴ෆ䛷ฟ⏕䛧䛯ඣ䜢ᑐ㇟䛻 ALD 䜢ྵ䜑䛯 7 䛴䛾⑌ᝈ䜢㏣ຍ䛧䛯᪂䛯䛺᪂⏕ඣ䝇䜽䝸䞊䝙䞁䜾᳨ᰝ䛜㛤ጞ䛥䜜䚸௧࿴ 4 ᖺ௨㝆䛿ẖ᭶䚸ᒱ㜧┴ෆฟ⏕䛾 80%㏆䛟䛾㉥䛱䜓䜣䛜ཷ᳨䛧䛶䛔䜎䛩䠄http://www.tokai-mass.jp䠅䚹䜎䛯ឡ▱┴䛷䜒ᚑ᮶䛾㏣ຍ᳨ᰝ䛻 ALD 䛜ຍ䜟䜚䚸୧┴䛷඲ᅜ䛻ඛ㥑䛡䛶 ALD 䛾᪂⏕ඣ䝇䜽䝸䞊䝙䞁䜾᳨ᰝ䛜ᐇ᪋䛥䜜䚸㝧ᛶ⪅䛾⢭ᐦデ᩿䛿඲䛶㞴⑓᳨ᰝᐊཬ䜃䚸㑇ఏᏊ᳨ᰝᐊ䛷⾜䜟䜜䛶䛔䜎䛩䚹㑇ఏᏊ᳨ᰝᐊ㛤タ᫬䛾ෆぴ఍䛷䛿ྜྷ⏣⑓㝔㛗䠄⌧䚸Ꮫ㛗䠅䜔⋤๪Ꮫ㛗䞉㧗➼◊✲㝔㛗䛛䜙䚸䛂඲ᅜ㞴⑓ᝈ⪅䛾デ᩿ᐇ⦼䜢✚䜏㔜䛽䛶䚸♫఍㈉⊩䛛䜙኱Ꮫ䛾䝥䝺䝊䞁䝇ྥୖ䛻ᐤ୚䛩䜛䛣䛸䜢ᮇᚅ䛧䛶䛔䜎䛩䛃䛸⃭ບ䛥䜜䜎䛧䛯䠄෗┿䠅䚹ึᖺᗘ䛸䛺䜛௧࿴ 3 ᖺᗘ䛾㑇ఏᏊ᳨ᰝᐊ䛻䛚䛡䜛 ALD 㑇ఏᏛⓗ᳨ᰝ䛾ཷクゎᯒᐇ⦼䛸䛧䛶䛿㝔ෆ 20௳䚸㝔እ 58 ௳䚸䛣䛾䛖䛱ྡྂᒇ኱Ꮫ⑓㝔䜘䜚 24 ௳䛾ゎᯒ౫㢗䛜䛒䜚䚸デ᩿⤖ᯝ䜢㎿㏿䛻ᥦ౪䛧䚸ᒱ㜧኱Ꮫ䛾་⒪ᐇ⿦䛸䛧䛶♫఍䛻㈉⊩䛧䛶䛔䜎䛩䚹ᘬ䛝⥆䛝䚸඲ᅜ䛾ᑐ㇟㞴⑓ᝈ⪅䛾᪩ᮇデ᩿䛛䜙⑌ᝈඞ᭹䛻ྲྀ䜚⤌䜐䛸䛸䜒䛻䚸Ꮫෆ䛻䛚䛡䜛デ᩿㛤Ⓨ◊✲䛾⮫ᗋᐇ⿦䜢ᨭ᥼䛧䛯䛔䛸⪃䛘䛶䛔䜎䛩䚹ෆぴ఍෗┿ 2021 ᖺ 4 ᭶䠄ᕥ䛛䜙䠅 ྜྷ⏣⑓㝔㛗䠄⌧Ꮫ㛗䠅䚸㧗ᓥຓᩍ䠄⌧෸ᩍᤵ䠅䚸ୗ⃝ศ㔝㛗䠄⌧≉௵ᩍᤵ䠅䚸Ώ㑓᳨ᰝ㒊๪㒊㛗䚸⋤๪Ꮫ㛗䠈⏣୰䝉䞁䝍䞊㛗䠄⌧᎘Ẽᛶ⳦◊✲ศ㔝㛗䠅

5
ࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : mgrc@gifu-u.ac.jp
TEL : 058-293-3171
FAX : 058-293-3172

┠࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭‫✲◊ ی‬ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊ㛗࠶࠸ࡉࡘ


ἢ㠉

 ᩍ⫋ဨ


ḟ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

άື⤂௓࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭




 ཷクゎᯒࢧ࣮ࣅࢫ฼⏝᱌ෆ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

‫⦅࣒ࣀࢤ ە‬㞟࣐࢘ࢫసᡂཷクࢧ࣮ࣅࢫ‫⦅࣒ࣀࢤ ە‬㞟⣽⬊స〇ཷクࢧ࣮ࣅࢫ‫ ە‬㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾ཷクศᯒࢧ࣮ࣅࢫ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊ◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊ㛗࣭ᐊဨ㧗ᓥ ⱱ㞝ࠊᇼ஭ ᭷ᕼ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࡛ࡣᵝࠎ࡞ཷクゎᯒࢧ࣮ࣅࢫࢆᥦ౪ࡍࡿࡇ࡜࡛ࠊᏛෆࡢ◊✲άືࢆᨭ᥼ࡋ࡚࠸ࡲࡍࠋࡉࡽ࡟ከᙬ࡞ཷクゎᯒࢧ࣮ࣅࢫࢆ」ᩘࡢศ㔝࡛༠ຊࡋ࡚⾜࠺ࡓࡵ࡟ࠊ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࡛ࡣ௧࿴ 3 ᖺᗘ࠿ࡽࠕ◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊࠖࢆ❧ࡕୖࡆࡲࡋࡓࠋ
ᮏ⤫ᣓᐊ࡟ࡣࢤࣀ࣒◊✲ศ㔝ࡢ㧗ᓥ࡜ື≀ᐇ㦂ศ㔝ࡢᇼ஭ࡀᅾ⡠ࡋࠊ᪂ࡓ࡞ཷクゎᯒࢧ࣮ࣅࢫࡢᵓ᝿࣭㛤Ⓨ࣭ᐇ⿦໬ࢆ㐍ࡵ࡚࠸ࡲࡍࠋ
ࡇࢀࡲ࡛࡟㑇ఏᏊ⦅㞟࣐࢘ࢫసᡂཷクࢧ࣮ࣅࢫࠊ㑇ఏᏊ⦅㞟⣽⬊ཷクసᡂࢧ࣮ࣅࢫࠊ㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾ཷクゎᯒࢧ࣮ࣅࢫࡢ3 ࡘࡢࢧ࣮ࣅࢫࡢᐇ⿦໬ࢆ⾜࠸ࠊࡍ࡛࡟Ꮫෆ࣭Ꮫࡢ
୧᪉࠿ࡽࡈ౫㢗ࢆ࠸ࡓࡔ࠸࡚࠸ࡲࡍࠋࢧ࣮ࣅࢫࡢヲ⣽ࡣୗグࠊ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࣮࣍
࣒࣮࣌ࢪ࠿ࡽࡈぴ࠸ࡓࡔࡅࡲࡍࠋ௒ᚋࡶ᪂ࡓ࡞ཷクゎᯒࢧ࣮ࣅࢫࢆ㛤Ⓨ࣭ᥦ౪ࡍࡿࡇ࡜࡛
ࠊ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࡢࢧ࣮ࣅࢫࢆᣑ඘ࡋࠊᏛෆࡢ◊✲ຊᙉ໬ࢆ㐍ࡵ࡚࠸ࡁࡲࡍࠋ

⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮+3 ࡼࡾ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࣮࣒࣮࣍࣌ࢪ 85/㸸KWWSVZZZJLIXXDFMSaOVUFLQGH[KWPO

6

1. 
௧࿴ 3 ᖺ 4 ᭶㧗➼◊✲㝔 ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ෆ࡟◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊࢆタ⨨

2. ᩍ⫋ဨ෸ᩍᤵ 㧗ᓥ ⱱ㞝 (ࢤࣀ࣒◊✲ศ㔝)ຓᩍᇼ஭ ᭷ᕼ㸦ື≀ᐇ㦂ศ㔝㸧

3. άື⤂௓㸦㸯㸧άືෆᐜ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࡢ」ᩘࡢศ㔝ࡀඹྠ࡛⾜࠺ࠊ᪂ࡓ࡞ཷクゎᯒࢧ࣮ࣅࢫࡢᵓ᝿࣭
㛤Ⓨ࣭ᐇ⿦㸦㸰㸧ᙜᐊ࡛㛤Ⓨࡋࡓཷクゎᯒࢧ࣮ࣅࢫ
‫⦅࣒ࣀࢤ ە‬㞟࣐࢘ࢫసᡂཷクࢧ࣮ࣅࢫ
CRISPR/Cas9 ࢆ⏝࠸ࡓ㑇ఏᏊ◚ቯ࣐࢘ࢫࡢసᡂࢆ⾜࠺ࢧ࣮ࣅࢫ࡛ࡍࠋgRNA ࡢࢹࢨ࢖ࣥ࠿ࡽࠊ⬇࡬ࡢ gRNA/Cas9 ࡢ࢚ࣞࢡࢺ࣏࣮ࣟࣞࢩࣙࣥࠊ⏘௘ࡢࢪ࢙ࣀࢱ࢖
ࣆࣥࢢࡲ࡛ࢆ⾜࠸ࡲࡍࠋ‫⦅࣒ࣀࢤ ە‬㞟⣽⬊స〇ཷクࢧ࣮ࣅࢫ
CRISPR/Cas9 ࢆ⏝࠸ࡓ㑇ఏᏊ◚ቯ࣐࢘ࢫࡢసᡂࢆ⾜࠺ࢧ࣮ࣅࢫ࡛ࡍࠋgRNA ࡢࢹࢨ࢖ࣥ࠿ࡽࠊ⣽⬊࡬ࡢ gRNA/Cas9 ࡢ࢚ࣞࢡࢺ࣏࣮ࣟࣞࢩࣙࣥࠊ1 ⣽⬊ࢡ࣮ࣟࣥࡢ༢㞳࡜ࢪ࢙ࣀࢱ࢖ࣆࣥࢢࡲ࡛ࢆ⾜࠸ࡲࡍࠋ‫ ە‬㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾ཷクศᯒࢧ࣮ࣅࢫ
⣽⬊ࡸ⤌⧊ࡢᅛᐃࠊ⬺Ỉࠊࣇ࣮ࣜࢬࢻࣛ࢖ฎ⌮ࠊ࢜ࢫ࣑࣒࢘ࢥ࣮ࢸ࢕ࣥࢢࡲ࡛ࡢ๓ฎ⌮࠿ࡽࠊ㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾ࢆ⏝࠸ࡓほᐹ࡜෗┿᧜ᙳࡲ࡛ࢆ⾜࠺ࢧ࣮ࣅࢫ࡛ࡍࠋ࣮ࣜࣔࢺほᐹࡶྍ⬟࡛ࡍࠋ㠀⏕≀ヨᩱ࡟ࡶᑐᛂࠋ

7

4

ว໣প৾ ৈಉଢ଼஢੹

ఐ৾ଢ଼஢੦ೕ७থॱ‫ ش‬ଢ଼஢੦ೕ৫৅௓ਤଁฐ஼

१‫ش‬অ५໪ਏ

ম१‫ش‬অ५म‫ؚ‬।ঀ঒ౣૐঐक़५भ੿ਛभञीप૑ਏऩफ़ॖॻ RNA भ੿ਛ‫ؚ‬ঐक़५ਭಖຼ
पৌघॊ।ঀ঒ౣૐ૪઼‫ؚ‬ᶦ୎೘఺ल৿੟भ༩୘॑৻ষघॊ१‫ش‬অ५दघ‫؛‬‫پ‬ਓᐺऋ੭ैोऩःৃ়‫ؚ‬ଈಝखञৃ়‫ؚ‬৯৓भ।ঀ঒ଦഔऋ੭ैोऩःৃ়पउःथु‫ؚ‬મসऋ৅েखऽघ‫؛‬१‫ش‬অ५৔ઍ

ःङोऊभউছথ॑उ৭लऎटऔः‫؛‬x੦মউছথ
फ़ॖॻ RNA भਝੑफ़ॖॻ RNA भିધ಍ཝपउऐॊभ।ঀ঒ౣૐ஍ટभનੳ
ਭಖຼभ૆૟
ग़ঞॡॺটএঞ‫ش‬३ঙথपेॊ।ঀ঒ౣૐ૪઼
ෘ஡षभᶦ୎೘
150,000 ৞x৿੟੿ਛ੿঵উছথ

‫پ‬फ़ॖॻ RNA भਝੑ‫ିؚ‬ધ‫ؚ‬નੳ‫ؚ‬෯২৹ତ॑ൂ౅঻भ੔েपষढथः

ञटऎউছথदघ‫؛‬ਭಖຼभ૆૟
ग़ঞॡॺটএঞ‫ش‬३ঙথपेॊ।ঀ঒ౣૐ૪઼
ෘ஡षभᶦ୎೘
100,000 ৞ड़উ३ঙথ੿঵

঱੶উছথधभ७ॵॺदभड़উ३ঙথ੿঵॑ষअऒधऋदऌऽघ‫؛‬হ৐भउணख੢ाध୯ਸમসऋ૑ਏदघ‫؛‬



x
x
x

ളਯभफ़ॖॻ RNA भઞ৷๦௝જ৫भ৻ষ
F0 ঐक़५ DNA ३‫ش‬ॡग़থ५ੰෲ

१‫ش‬অ५भ૴ो

x੦মউছথ‫؝ڭ‬হ৐ৼ୥ண੢છ‫ق‬஘ૄ‫كڭ‬भ઀ল‫ڀ঻౅ൂق‬७থॱ‫كش‬‫؝ڮ‬হ৐ৼ୥
‫ڀ঻౅ൂق‬७থॱ‫كش‬‫؝گ‬মண੢છ‫ق‬஘ૄ‫كڮ‬भ઀ল‫؝ڰ‬फ़ॖॻ RNA भਝੑ‫؝ڱ‬फ़ॖॻ RNA भିધ‫؝ڲ‬಍ཝदभ஍ટभનੳ
‫৾؝ڳ‬৔੻৩ভपेॊഅੳभનੳછ‫ق‬஘ૄ‫كگ‬भ઀ল ‫ڀ঻౅ൂق‬७থॱ‫كش‬‫৿؝ڴ‬੟੿ਛ੿঵঩ங਀‫ق‬஘ૄ‫كڰ‬भଛહ‫ق‬७থॱ‫ك঻౅ൂڀش‬‫؝ڵ‬ਭಖຼभ૆૟
‫؝ڬڭ‬।ঀ঒ౣૐ૪઼
‫؝ڭڭ‬ෘ஡षभᶦ୎೘
‫؝ڮڭ‬ਬऌநख

x৿੟੿ਛ੿঵উছথ
‫؝ڭ‬হ৐ৼ୥ண੢છ‫ق‬஘ૄ‫كڭ‬भ઀ল‫؝ڮ‬হ৐ৼ୥
‫؝گ‬মண੢છ‫ق‬஘ૄ‫كڮ‬भ઀ল‫৾؝ڰ‬৔੻৩ভपेॊഅੳभનੳછ‫ق‬஘ૄ‫كگ‬भ઀ল‫৿؝ڱ‬੟੿ਛ੿঵঩ங਀‫ق‬஘ૄ‫كڰ‬भଛહ‫؝ڲ‬ਭಖຼभ૆૟
‫؝ڳ‬।ঀ঒ౣૐ૪઼
‫؝ڴ‬ෘ஡षभᶦ୎೘
‫؝ڵ‬ਬऌநख

‫ڀ঻౅ൂق‬७থॱ‫كش‬‫ڀ঻౅ൂق‬७থॱ‫كش‬‫ڀ঻౅ൂق‬७থॱ‫كش‬‫ق‬७থॱ‫ك঻౅ൂڀش‬‫پ‬७থॱ‫ ؟ش‬ว໣প৾ ৈಉଢ଼஢੹ ఐ৾ଢ଼஢੦ೕ७থॱ‫ ش‬ଢ଼஢੦ೕ৫৅௓ਤଁฐ஼

80उணख੢ा

ओହ৥॑उഭाःञटऌ‫ؚ‬হ৐ৼ୥ண੢છ॑ओ੶োभअइ‫ؚ‬ৈಉଢ଼஢੹ ఐ৾ଢ଼஢੦ೕ७থॱ‫ ش‬ଢ଼஢੦ೕ৫৅௓ਤଁฐ஼
૿ਊ൘੩‫ق‬yhorii‫ٯ‬gifu-u.ac.jp‫ك‬षओ઀লऎटऔः‫؛‬उਖः়ॎच੔

‫৿؞‬੟੿ਛ੿঵‫ؚ‬ম१‫ش‬অ५৸ಹपणःथ
৿੟ৰୡী৙
൘੩થൌ‫؞‬gRNA भਝੑಉपणःथ
।ঀ঒ଢ଼஢ী৙

ৈਣൄ௟

81

mail: yhorii‫ٯ‬gifu-u.ac.jp
৔଍: 6610

mail: staka‫ٯ‬gifu-u.ac.jp
৔଍: 3174ΰόϞฦॄϜΤηࡠ੔ण୙γʖϑη ࣆ઴૮஌ਅࠒॽ

ʤ༹ࣞ̏ʥ

఑ड़ೖ

೧

࿰಼Ν͟೘ྙ͹৏ɼϟʖϩశ෉Ͷͱ͟఑ड़͚ͫ͠͏ɽ
ᶅ

ॶ଒

ғབं

ࢱ໌
࿊ཙ઎

Tel

Mail

ᶆ

Ҫఽࢢ໌Ήͪͺ gene symbol

ଲেҪఽࢢ

NCBI gene ID໪ద˚όρέΠΤφ ˚ͨ͹ଠʤʥᶇʤ͏ͥΗ͖̏ͯΝમ୔͢ͱ͚ͫ͠͏ɽʥ

ғབϕϧϱ

˚

‫خ‬ຌϕϧϱʤΪ΢χ RNA ͹અ‫ܯ‬ʛಊ෼ࡠ੔ࡠ‫ۂ‬ʥ˚ಊ෼ࡠ੔ࡠ‫ۂ‬ϕϧϱʤΪ΢χ RNA Ν͟༽қ͏͚ͪͫ৖߻ʥ

ᶈʤࣆ઴Ͷ૮஌ͪ͢͏಼༲͍͗Ηͻ͟‫ى‬೘͚ͫ͠͏ɽ
ʥ࣯͟໲౵‫خڂݜ‬൭ιϱνʖ

ғབ൬ߺ

‫ى‬೘ཟ

ࣆ઴૮஌ೖఖ

ʌʌʌʌʌʌʌʌ
೧ຌਅࠒΊ ໃ ʀ༙ ʤ

݆
೧

82

݆

ೖ ʤ୴౲
ೖʥ

ʥ

݆

ೖ

ΰόϞฦॄϜΤηࡠ੔ण୙γʖϑη ࣆ઴૮஌ਅࠒॽ

ʤ༹ࣞ̏ʥ‫ى‬೘ྭͳ͟ઈ໎
఑ड़ೖ೧࿰಼Ν͟೘ྙ͹৏ɼϟʖϩశ෉Ͷͱ͟఑ड़͚ͫ͠͏ɽ
ᶅॶ଒˕˕‫ڂݜ‬Ռ ʕʕ‫࣪ڂݜ‬

ғབं

ࢱ໌

ΰόϞ ଢ࿢

࿊ཙ઎

Tel

̗̗̗̗

Mail ˕˕˕@˕˕˕˕ᶆҪఽࢢ໌Ήͪͺ gene symbol

AAAA

ଲেҪఽࢢ

NCBI gene ID

aa00000໪ద˛όρέΠΤφ ˚ͨ͹ଠʤʥᶇʤ͏ͥΗ͖̏ͯΝમ୔͢ͱ͚ͫ͠͏ɽʥ

ғབϕϧϱ

˚

‫خ‬ຌϕϧϱʤΪ΢χ RNA ͹અ‫ܯ‬ʛಊ෼ࡠ੔ࡠ‫ۂ‬ʥ˚ಊ෼ࡠ੔ࡠ‫ۂ‬ϕϧϱʤΪ΢χ RNA Ν͟༽қ͏͚ͪͫ৖߻ʥ

ᶈʤࣆ઴Ͷ૮஌ͪ͢͏಼༲͍͗Ηͻ͟‫ى‬೘͚ͫ͠͏ɽ
ʥ࣯͟໲౵‫خڂݜ‬൭ιϱνʖ

ғབ൬ߺ

‫ى‬೘ཟ

ࣆ઴૮஌ೖఖ

ʌʌʌʌʌʌʌʌ
೧ຌਅࠒΊ ໃ ʀ༙ ʤ

݆
೧

83

݆

ೖ ʤ୴౲
ೖʥ

ʥ

݆

ೖ

ࣆ઴ਅࠒॽ͟‫ى‬೘Ͷ͍ͪͮͱ͹͟ઈ໎γʖϑη֕གྷ
ຌγʖϑηͺɼΰόϞฦॄ࣎Ͷචགྷͳ͵ΖΪ΢χ RNA ͹ࡠ੔ɼϜΤηण੠ཝͶଲͤΖΰόϞฦॄॴ஖ɼ
ᡤҢ৪‫;ٶ‬ಊ෼͹ࣄүΝେߨͤΖγʖϑηͲͤɽˠࢊ࢖͗ಚΔΗ͵͏৖߻ɼࢰ๤ͪ͢৖߻‫;ٶ‬໪ద͹ΰόϞഓ྽͹ࢊ࢖͗ಚΔΗ͵͏৖߻΍ɼྋۜ͗൅ਫ਼͢Ήͤɽγʖϑη಼༲
‫خ‬ຌϕϧϱ

ʤ150,000 ԃˠ̐յͶ෾͜ͱ͹͕ࢩ෹͏Ͷ͵ΕΉͤʥʀΪ΢χ RNA ͹અ‫ܯ‬ʀΪ΢χ RNA ͹஭ชʀin vitro Ͳ͹ްՎ͹֮೟

ʤ50,000 ԃ͕ࢩ෹͏ʥ

ʀण੠ཝ͹६ඍ
ʀΦϪέφϫϛϪʖεϥϱͶΓΖΰόϞฦॄॴ஖ʀՀ਎΃͹ᡤҢ৪ಊ෼ࡠ੔ࡠ‫ۂ‬ϕϧϱ

ʤ100,000 ԃ͕ࢩ෹͏ʥ

ʤ100,000 ԃʥʀण੠ཝ͹६ඍ
ʀΦϪέφϫϛϪʖεϥϱͶΓΖΰόϞฦॄॴ஖ʀՀ਎΃͹ᡤҢ৪ˠΪ΢χ RNA ͹અ‫ܯ‬ɼ஭ชɼೳౕ௒੖Νғབं͹઎ਫ਼Ͷߨͮͱ͏͚ͪͫϕϧϱͲͤɽ͕໲͏߻Κͦ઎ʀਅࠒॽૻ෉઎
‫ز‬෠୉ָ ߶౵‫ڂݜ‬ӅՌָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ׇ࣪‬ຉҬ༙‫س‬

mail: yhorii@gifu-u.ac.jp
಼ત: 66108ΰόϞฦॄϜΤηࡠ੔ण୙γʖϑη ຌਅࠒॽʤ༹ࣞ̐ʥՌָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ా ׇ࣪‬ҐԾ͹಼༲Ͷͱࡠ‫ۂ‬ण୙Νਅ͢ࠒΊΉͤɽ೧ᶅॶ଒ࣰ‫੻ݩ‬೜ं

ࢱ໌
࿊ཙ઎

Tel

Mail

ᶆ

˚ࣰ‫੻ݩ‬೜ंͳಋͣ ʤࣰ‫੻ݩ‬೜ंͳҡ͵Ζ৖߻ͺҐԾͶ‫ى‬೘ʥ‫ܨ‬ඇෝ୴ं

ॶ଒
ࢱ໌
࿊ཙ઎

Tel

Mail

ᶇ

˚ࣰ‫੻ݩ‬೜ंͳಋͣ ˚‫ܨ‬ඇෝ୴ंͳಋͣ (ҡ͵Ζ৖߻ҐԾͶ‫ى‬೘)

ࣄү୴౲ं

ॶ଒
ࢱ໌
࿊ཙ઎

Tel

Mail

ᶈ

ʤ͏ͥΗ͖̏ͯΝમ୔͢ͱ͚ͫ͠͏ɽʥ

ғབϕϧϱ

˚

‫خ‬ຌϕϧϱʤΪ΢χ RNA ͹અ‫ܯ‬ʛಊ෼ࡠ੔ࡠ‫ۂ‬ʥ˚ಊ෼ࡠ੔ࡠ‫ۂ‬ϕϧϱʤΪ΢χ RNA Ν͟༽қ͏͚ͪͫ৖߻ʥ

ᶉҪఽࢢ໌Ήͪͺ gene symbol

ଲেҪఽࢢ

NCBI gene IDᶊʤ͏ͥΗ͖̏ͯΝમ୔͢ͱ͚ͫ͠͏ɽʥಊ෼͹˚͕ో࣎͢‫غ‬˚ ৿ਫ਼ࣉʤ཯೗઴ʥ ˠՀ਎ͳҲॻͶ͕ో͢͢Ήͤɽ৿ਫ਼ࣉʤ཯೗‫ޛ‬ʥ ˠ̑ुྺͲ͕ో͢͢Ήͤɽ˚ ᡤҢ৪‫ޛ‬ʛೝ৹஦ ˠՀ਎Ν͕ో͢͢Ήͤᶋ˚ ෵਼͹ gRNA ౵͹࢘༽

Ψϕεϥϱ

˚

ʤ௧Յྋۜʥ ˚ఉԨ઀֋͹େߨʤ౲γʖϑηͲ͹ᡤҢ৪‫ݺ‬ର͹Ίʥ
F0 ϜΤη DNA εʖέΦϱηմੵγʖϑη‫خڂݜ‬൭ιϱνʖғབ൬ߺʌʌʌʌʌʌʌ‫ى‬೘ཟૌΊ‫ ͓׷‬DNA ࣰ‫ܯݩ‬ժॽ ট೟൬ߺʌʌʌʌʌʌʌʌʌʌ
ಊ෼ࣰ‫ܯݩ‬ժॽӀో͢༩ఈೖ

ট೟൬ߺʌʌʌʌʌʌʌʌʌʌ
೧

݆

5

ೖ

୴౲ʌʌʌʌʌʌʌ

݆ೖΰόϞฦॄϜΤηࡠ੔ण୙γʖϑη ຌਅࠒॽʀ‫ى‬೘ྭʤ༹ࣞ̐ʥՌָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ా ׇ࣪‬ҐԾ͹಼༲Ͷͱࡠ‫ۂ‬ण୙Νਅ͢ࠒΊΉͤɽ೧ᶅॶ଒˕˕‫ڂݜ‬Ռ ʕʕ‫࣪ڂݜ‬ࣰ‫੻ݩ‬೜ं

ࢱ໌ΰόϞ ଢ࿢

࿊ཙ઎

Tel

̗̗̗̗

Mail ˕˕@˕˕˕˕ᶆ˛ࣰ‫੻ݩ‬೜ंͳಋͣ ʤࣰ‫੻ݩ‬೜ंͳҡ͵Ζ৖߻ͺҐԾͶ‫ى‬೘ʥ‫ܨ‬ඇෝ୴ं

ॶ଒
ࢱ໌
࿊ཙ઎

Tel

Mail

ᶇ

˚ࣰ‫੻ݩ‬೜ंͳಋͣ ˚‫ܨ‬ඇෝ୴ंͳಋͣ (ҡ͵Ζ৖߻ҐԾͶ‫ى‬೘)

ࣄү୴౲ं

ॶ଒

˕˕‫ڂݜ‬Ռ ˕˕‫࣪ڂݜ‬ࢱ໌ΰόϞ ՘ࢢ

࿊ཙ઎

Tel

̎̎̎̎

Mail ˜˜@˜˜˜˜ᶈʤ͏ͥΗ͖̏ͯΝમ୔͢ͱ͚ͫ͠͏ɽʥ

ғབϕϧϱ

˛

‫خ‬ຌϕϧϱʤΪ΢χ RNA ͹અ‫ܯ‬ʛಊ෼ࡠ੔ࡠ‫ۂ‬ʥ˚ಊ෼ࡠ੔ࡠ‫ۂ‬ϕϧϱʤΪ΢χ RNA Ν͟༽қ͏͚ͪͫ৖߻ʥ

ᶉҪఽࢢ໌Ήͪͺ gene symbol

ଲেҪఽࢢ

NCBI gene IDᶊʤ͏ͥΗ͖̏ͯΝમ୔͢ͱ͚ͫ͠͏ɽʥಊ෼͹˛͕ో࣎͢‫غ‬˚ ৿ਫ਼ࣉʤ཯೗઴ʥ ˠՀ਎ͳҲॻͶ͕ో͢͢Ήͤɽ৿ਫ਼ࣉʤ཯೗‫ޛ‬ʥ ˠ̑ुྺͲ͕ో͢͢Ήͤɽ˚ ᡤҢ৪‫ޛ‬ʛೝ৹஦ ˠՀ਎Ν͕ో͢͢Ήͤᶋ˛ ෵਼͹ gRNA ౵͹࢘༽

Ψϕεϥϱ

˚

ʤ௧Յྋۜʥ ˚ఉԨ઀֋͹େߨʤ౲γʖϑηͲ͹ᡤҢ৪‫ݺ‬ର͹Ίʥ
F0 ϜΤη DNA εʖέΦϱηմੵγʖϑη‫خڂݜ‬൭ιϱνʖғབ൬ߺʌʌʌʌʌʌʌ‫ى‬೘ཟૌΊ‫ ͓׷‬DNA ࣰ‫ܯݩ‬ժॽ ট೟൬ߺʌʌʌʌʌʌʌʌʌʌ
ಊ෼ࣰ‫ܯݩ‬ժॽӀో͢༩ఈೖ

ট೟൬ߺʌʌʌʌʌʌʌʌʌʌ
೧

݆



ೖ

୴౲ʌʌʌʌʌʌʌ

݆ೖ಼ָҗҽճট೟֮೟ॽʤ༹ࣞ̑ʥ

೧Ռָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ׇ࣪‬ௗ

݆

ೖ

ా

ΰόϞฦॄϜΤηࡠ੔ण୙γʖϑηͶͯ͘Ή͢ͱɼԾ‫ى‬͹௪Ε಼ָҗҽճ΃͹ਅ੧͗ট೟͠ΗΉͪ͢͹Ͳɼಊ෼ࡠ੔ࡠ‫ۂ‬͹֋࢟Νғབ͢Ήͤɽᶅॶ଒ࣰ‫੻ݩ‬೜ं

ࢱ໌
࿊ཙ઎

Tel

ᶆ

Ҫఽࢢ໌Ήͪͺ gene symbol

ଲেҪఽࢢ

NCBI gene ID

Mail

ᶇ
ট೟൬ߺ

ૌΊ‫ ͓׷‬DNA ࣰ‫ܯݩ‬ժॽ ট೟൬ߺʌʌʌʌʌʌʌʌʌʌʌʌʌʌʌ
ಊ෼ࣰ‫ܯݩ‬ժॽট೟൬ߺʌʌʌʌʌʌʌʌʌʌʌʌʌʌʌ

6ಊ෼ࡠ੔ࡠ‫ۂ‬ೖఖනʤ༹ࣞ̒ʥʌʌʌʌʌʌ‫࣪ڂݜ‬ʌʌʌʌʌʌ઎ਫ਼

ΰόϞฦॄϜΤηࡠ੔ण୙γʖϑηʰಊ෼ࡠ੔ࡠ‫ۂ‬ʱͶͯ͘Ή͢ͱ಼ָҗҽճ΃͹ট೟֮͗೟͠ΗΉͪ͢͹Ͳɼಊ෼ࡠ੔ࡠ‫ۂ‬Ν֋࢟͏ͪ͢ΉͤɽԾ‫ى‬͹ೖఖͶͱࡠ‫ۂ‬Νߨ͏Ήͤ͹Ͳɼࣄү͹͟६ඍΝ͕‫ͪ͢͏͏ب‬Ήͤɽࡠ‫ۂ‬஦இ͹͟‫س‬๮͗͟͡͏Ήͪ͢Δɼ͕૥ΌͶ͟࿊ཙ͚ͫ͠͏ɽ͵͕ɼ੧‫ֻٽ‬Ν‫͘Ͳֻݰ‬ΖՆ೵੓͍͗
ΕΉͤɽण੠ཝ͹ࡠ੔ʁ݆ೖΰόϞฦॄࡠ‫ ۂ‬ʁ݆ೖՀ਎΃͹Ң৪

ʁ

݆

ೖ

ड़ࢊ༩ఈೖ

ʁ

݆

ೖ

Ӏ͘ో͢‫ݸغ‬ʁ݆ೖ࢓ఈӀ͘ో͢ೖ ʁ݆ೖ‫ز‬෠୉ָ ߶౵‫ڂݜ‬Ӆ Ռָ‫خڂݜ‬൭ιϱνʖ‫خڂݜ‬൭֋൅ਬ਒౹‫ׇ࣪‬ಊ෼ࣰ‫ݩ‬෾໼୴౲ʁຉҬ
mail: yhorii@gifu-u.ac.jp

7ΰόϞฦॄϜΤηࡠ੔ण୙γʖϑη͹घӀ̏͘ɿγʖϑη֕གྷຌγʖϑηͺɼΰόϞฦॄ࣎Ͷචགྷͳ͵ΖΪ΢χ RNA ͹ࡠ੔ɼϜΤηण੠ཝͶଲͤΖΰόϞฦॄॴ஖ɼ
ᡤҢ৪‫;ٶ‬ಊ෼͹ࣄүΝେߨͤΖγʖϑηͲͤɽˠࢊ࢖͗ಚΔΗ͵͏৖߻ɼࢰ๤ͪ͢৖߻‫;ٶ‬໪ద͹ΰόϞഓ྽͹ࢊ࢖͗ಚΔΗ͵͏৖߻΍ɼྋۜ͗൅ਫ਼͢Ήͤɽ̐ɿγʖϑη಼༲‫خ‬ຌϕϧϱ

ʤ150,000 ԃˠ̐յͶ෾͜ͱ͹͕ࢩ෹͏Ͷ͵ΕΉͤʥʀΪ΢χ RNA ͹અ‫ܯ‬ʀΪ΢χ RNA ͹஭ชʀin vitro Ͳ͹ްՎ͹֮೟

ʤ50,000 ԃ͕ࢩ෹͏ʥ

ʀण੠ཝ͹६ඍ
ʀΦϪέφϫϛϪʖεϥϱͶΓΖΰόϞฦॄॴ஖ʀՀ਎΃͹ᡤҢ৪ಊ෼ࡠ੔ࡠ‫ۂ‬ϕϧϱ

ʤ100,000 ԃ͕ࢩ෹͏ʥ

ʤ100,000 ԃʥʀण੠ཝ͹६ඍ
ʀΦϪέφϫϛϪʖεϥϱͶΓΖΰόϞฦॄॴ஖ʀՀ਎΃͹ᡤҢ৪ˠΪ΢χ RNA ͹અ‫ܯ‬ɼ஭ชɼ֮೟ɼೳౕ௒੖Νғབं͹઎ਫ਼Ͷߨͮͱ͏͚ͪͫ
ϕϧϱͲͤɽ
̑ɿण୙γʖϑη͹ླྀΗʤ‫خ‬ຌϕϧϱʥᶅ ࣆ઴૮஌ਅࠒॽʤ༹ࣞ̏ʥ͹఑ड़ʤғབंˢιϱνʖˠʥᶆ ࣆ઴૮஌ᶇ ຌਅࠒॽʤ༹ࣞ̐ʥ͹఑ड़ᶈ Ϊ΢χ RNA ͹અ‫ܯ‬ᶉ Ϊ΢χ RNA ͹஭ชᶊ ࡋ๖Ͳ͹ްՎ͹֮೟ʤғབंˢιϱνʖʥғབं͹઎ਫ਼ࣙ͟ਐͲߨ͑৖߻ɼ
ʰಊ෼ࡠ੔ࡠ‫ۂ‬ϕϧϱʱΝ͕મ;͚ͫ͠͏ɽ ʤ-50,000 ԃʥᶋ ಼ָҗҽճͶΓΖট೟͹֮೟ॽʤ༹ࣞ̑ʥ͹఑ड़ʤғབंˢιϱνʖʥᶌ ಊ෼ࡠ੔ࡠ‫ۂ‬ೖఖනʤ༹ࣞ̒ʥ͹ૻ෉ʤιϱνʖˢғབंʥᶍ ण੠ཝ͹६ඍᶎ ΰόϞฦॄॴ஖ᶏ Հ਎΃͹ᡤҢ৪ᶐ Ӏ͘ో͢
ˠιϱνʖʤ֦झॽྪૻ෉઎ʥʁ ‫ز‬෠୉ָ ߶౵‫ڂݜ‬Ӆ Ռָ‫خڂݜ‬൭ιϱνʖ‫خڂݜ‬൭֋൅ਬ਒౹‫ ׇ࣪‬ಊ෼ࣰ‫ݩ‬෾໼ʤ୴౲ຉҬʥyhorii@gifu-u.ac.jp̑ɿʰ̐ɿण୙γʖϑη͹ླྀΗʱ͹৆ࡋઈ໎ᶅ ࣆ઴૮஌ਅࠒॽʤ༹ࣞ̏ʥ͹఑ड़ࢱ໌ɼଲেҪఽࢢɼғབϕϧϱ౵Ͷͯ͏ͱ೘ྙ͢ɼՌָ‫خڂݜ‬൭ιϱνʖʤ7.ૻ෉઎ʥΉͲ͟఑ड़͚
ͫ͠͏ɽᶆ ࣆ઴૮஌
ೖఖ௒੖͹৏ɼ৆͚͢͟ઈ໎ͦ͠ͱ͏ͪͫ͘Ήͤɽᶇ ຌਅࠒॽʤ༹ࣞ̐ʥ͹఑ड़ࣰ‫੻ݩ‬೜ंɼ‫ܨ‬ඇෝ୴ंɼࣄү୴౲ंࢱ໌ɼਅ͢ࠒΊϕϧϱɼΨϕεϥϱ͹‫س‬๮౵Ν೘ྙ͢ɼ͟఑
ड़͚ͫ͠͏ɽ
͵͕ɼΰόϞฦॄϜΤηΝ༽͏ࣰͪ‫ݩ‬Ͷͺʰಊ෼ࣰ‫ܯݩ‬ժॽʱ‫;ٶ‬ʰૌΊ‫ ͓׷‬DNA ࣰ‫ܯݩ‬ժॽʱΝ಼ָҗҽճͶͱট೟͠ΗΖචགྷ͍͗ΕΉͤɽғབंࣙ͟ਐͶͱ಼ָ͹֦җҽճ΃֦झࣰ‫ܯݩ‬ժॽΝ఑ड़͢ɼট೟Νಚͱ͕͏ͱ͚ͫ͠͏ɽ
‫ܯ‬ժॽ͹ࡠ੔Ͷͯ͘Ή͢ͱ͟෈໎͵఼͗͟͡͏Ήͪ͢Δ͟૮஌͚ͫ͠͏ɽᶈ Ϊ΢χ RNA ͹અ‫ܯ‬ࢨఈ͠Ηͪ DNA ഓ྽Ͷଲ͢ͱɼΪ΢χ RNAʤgRNAʥΝઅ‫͢ܯ‬Ήͤɽઅ‫ ͪ͢ܯ‬gRNA ͹ഓ྽Νๅࠄ͢Ήͤɽᶉ Ϊ΢χ RNA ͹஭ชғབंࣙਐͲഓ྽Ν֮೟͢ͱ͚ͫ͠͏ɽ֮೟͗‫׮‬྅࣏୊ɼgRNA Ν஭ช͢Ήͤɽᶊ ࡋ๖Ͳ͹ްՎ͹֮೟ࡋ๖΃ΦϪέφϫϛϪʖεϥϱ๑ͶΓΖΰόϞฦॄॴ஖‫ ;ٶ‬PCR մੵΝߨ͏ɼ஭ชͪ͢Ϊ΢χ RNA

50͹ഓ྽ͲΰόϞฦॄްՎ͗ಚΔΗΖ͖ʹ͖֮͑೟͢Ήͤɽ֮೟಼ͪ͢༲Νๅࠄ͢ΉͤɽʰՌָ‫خڂݜ‬൭ιϱνʖΰόϞ‫ڂݜ‬෾໼ʱΓΕ 50,000 ԃΝ੧‫͏ͱͦ͠ٽ‬ͪͫ͘Ήͤɽᶋ ಼ָҗҽճ͹ট೟֮೟ॽʤ༹ࣞ̑ʥ͹఑ड़ʰಊ෼ࣰ‫ܯݩ‬ժॽʱ‫;ٶ‬ʰૌΊ‫ ͓׷‬DNA ࣰ‫ܯݩ‬ժॽʱΝ఑ड़͢ɼ಼ָ͹֦җҽճ͖Δ͹ট೟͗ಚΔ
ΗΉͪ͢Δɼғབं͖ΔՌָ‫خڂݜ‬൭ιϱνʖʤ7.ૻ෉઎ʥ΃ɼʰ಼ָҗҽճট೟֮೟ॽʤ༹ࣞ̑ʥʱ
Ν͕ૻΕ͚ͫ͠͏ɽᶌ ಊ෼ࡠ੔ࡠ‫ۂ‬ೖఖනʤ༹ࣞ̒ʥ͹ૻ෉಼ָҗҽճ΃͹ট೟֮͗೟͠Η࣏୊ɼಊ෼ࡠ੔Ͷ‫ܐ‬ΖೖఖΝ݀ఈ͢Ήͤɽೖఖ͗݀ఈ͏ͪ͢Ήͪ͢Δɼ
Ռָ‫خڂݜ‬൭ιϱνʖ͖Δғབं΃ɼʰಊ෼ࡠ੔ࡠ‫ۂ‬ೖఖනʤ༹ࣞ̒ʥʱΝ͟ૻ෉͏ͪ͢Ήͤɽಊ෼͹Ӏ͘ో͢Ͷ޴͜ɼࣄү‫ܯ‬ժ͹௒੖Ν͕‫ͪ͢͏͏ب‬Ήͤɽᶍ ण੠ཝ͹६ඍϜΤηʤC57BL/6J ‫ܧ‬౹ʥ͹ण੠ཝ 100 ‫ݺ‬Ґ৏ΝࡀखͤΖ͞ͳΝฯৄ͢Ήͤɽᶎ ΰόϞฦॄॴ஖
ΦϪέφϫϛϪʖεϥϱ๑ͶΓΖΰόϞฦॄॴ஖Νߨ͵͏Ήͤʤˠ̏ʥɽᶏ Հ਎΃͹ᡤҢ৪࠹୉̒඘͹Հ਎ʤْೝ৹ͦͪ͠ ICR ‫ܧ‬౹ϜΤηʥ͹ཝ؇಼΃ण੠ཝΝҢ৪͢Ήͤɽ͵͕ɼҢ৪඘਼ͺण੠ཝ͹য়ସͶΓͮͱรΚΕΉͤɽࡠ‫ۂ‬͹श྅‫ޛ‬ɼๅࠄॽΝ೴඾͢ΉͤɽʰՌָ‫خڂݜ‬൭ιϱνʖಊ෼ࣰ‫ݩ‬෾໼ʱΓΕ 100,000 ԃΝ੧‫ٽ‬ͦ͠ͱ͏ͪͫ͘Ήͤʤˠ̐ʥɽᶐ Ӏ͘ో͢
ฦॄ͠ΗͪҪఽࢢͶΓΖ஗ໍద͵ҡ৙͗͵͏৖߻ɼण੠ཝ͹Ң৪͖Δ 20 ೖ‫ޛ‬Ͷ࢖͗ਫ਼ΉΗΉͤɽ̑ुྺΉͲಊ෼ࣄүࢬઅͶͱࣄүࡠ‫ۂ‬ʤίʖζި‫׷‬ʀ‫ڇ‬ਭʀ‫ڇ‬㕔౵͹ΊʥΝߨ͏Ήͤɽ͞͹ࡏɼන‫ݳ‬‫ܗ‬͹؏ࡱɼࣃ༦൓พɼ‫ݺ‬ରࣟพɼ౦༂౵ͺߨ͵͏ΉͦΞɽ̑ुྺҐ߳ͺғབंͶͱࣄүΝ͕‫ͪ͢͏͏ب‬Ήͤɽ‫س‬๮͍͗Ηͻण੠ཝҢ৪‫ޛ‬͹ೝ৹஦͹Հ਎
ʤICR ‫ܧ‬౹ϜΤηʥΏɼ̑ुྺາຮ͹ࢊ࢖͹Ӏ͘ో͗͢Ն೵Ͳͤɽ
ຬ͗Ҳɼ̑ुྺΝգ͙ͱ΍Ӏ͘ో͗͢ड़པ͵͏৖߻ɼ̓඘/1 ίʖζͶ෾ͪ͜৏ɼण୙ࣄүେʤ90
ԃ/ίʖζ/ೖʥ͗௧Յྋۜͳ͵ΕΉͤɽ̓ɿ஭қࣆߴˠ̏ ΦϪέφϫϛϪʖεϥϱࡠ‫ۂ‬Ͷͯ͏ͱਅࠒΊ͍̏݇ͪΕɼΦϪέφϫϛϪʖεϥϱॴ஖Ͷ༽͏Ζࢾ༂ʤCas νϱϏέ࣯ɼ໪ద͹ഓ྽Ͷಝ51ҡద͵ gRNAʥ͹ૌ੔‫;ٶ‬ೳౕͺɼ‫ݬ‬ଉ̏झྪͳ͵ΕΉͤɽˠ̐ ಊ෼ࡠ੔ࡠ‫ۂ‬Ͷͯ͏ͱ͟‫س‬๮͹ഓ྽͹Γͮͱɼࢊ࢖͗ಚΔΗ͵͏৖߻Ώɼ໪ద͹ഓ྽ͳ͵Ζི֮͗ఁ͏৖߻͍͗ΕΉͤɽ໪ద͹ࢊ࢖͗ಚΔΗ͵͏৖߻Ͷ΍େۜ͗൅ਫ਼͢Ήͤɽ6ɿΨϕεϥϱʤགྷʀࣆ઴ਅ͢ࠒΊʀ௧Յྋۜʥ
ʀ෵਼͹ gRNA ౵͹࢘༽ʤࣰඇʥ
໪ద͹ฦॄ಼༲ͶΓͮͱͺɼ෵਼͹ gRNA ౵͹࢘༽Ν͟఑Ҍͦ͠ͱ͏͚ͪͫ͞ͳ͍͗ΕΉͤɽʀఉԨ઀֋͹େߨʤ12,000 ԃʥ౲γʖϑηͶͱᡤҢ৪ΝߨͮͪՀ਎Ͷଲ͢ɼೝ৹ 20 ೖ໪ͶఉԨ઀֋Νߨ͵͏Ήͤɽ཮਎ʤಋ
ೖͶड़ࢊ༩ఈ͹ ICR ‫ܧ‬౹ϜΤηʥΝ߬೘͢ɼ৿ਫ਼ࣉΝ཯೗ΉͲಋ‫ͦ͠ڋ‬Ήͤɽ
ʀF0 ϜΤη DNA εʖέΦϱηմੵγʖϑη౲γʖϑηͲࡠ੔͠ΗͪϜΤη͹Ӏ͘ో͢‫ޛ‬ɼ࢖ϜΤη͹ΰόϞഓ྽͹մੵΝ͕घఽ͏͢Ήͤɽʤૌ৭͹ࡀख౵ͺғབंࣙ͟ਐͲߨͮͱ͚ͫ͠͏ɽ
ʥ
7ɿ֦झॽྪૻ෉઎
‫ز‬෠୉ָ ߶౵‫ڂݜ‬Ӆ Ռָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ׇ࣪‬ಊ෼ࣰ‫ݩ‬෾໼୴౲ʁຉҬ

mail: yhorii@gifu-u.ac.jp8ɿ͕໲͏߻Κͦ઎ʀΪ΢χ RNA ͹અ‫ܯ‬ɼࡋ๖Ͳ͹֮೟౵Ͷͯ͏ͱΰόϞ‫ڂݜ‬෾໼ ߶ౣໞ༦ mail: staka@gifu-u.ac.jp
಼ત: 3174ʀण੠ཝ͹६ඍɼᡤҢ৪౵ɼຌγʖϑηસൢͶͯ͏ͱಊ෼ࣰ‫ݩ‬෾໼ ຉҬ༙‫س‬

mail: yhorii@gifu-u.ac.jp
಼ત: 6610

9. ϙʖϞϘʖζ‫ز‬෠୉ָ ߶౵‫ڂݜ‬Ӆ Ռָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ׇ࣪‬ΰόϞฦॄϜΤηࡠ੔γʖϑη
https://www1.gifu-u.ac.jp/~lsrc/kst/kstgea/index.html
֦झ༹ࣞͺϙʖϞϘʖζ͖ΔξΤϱϫʖχͲ͘Ήͤɽ

52ว໣প৾ ৈಉଢ଼஢੹

ఐ৾ଢ଼஢੦ೕ७থॱ‫ ش‬ଢ଼஢੦ೕ৫৅௓ਤଁฐ஼

।ঀ঒ౣૐ಍ཝ੿ଲਭ౏१‫ش‬অ५१‫ش‬অ५໪ਏ

ম१‫ش‬অ५म‫ؚ‬।ঀ঒ౣૐ಍ཝ੿ਛभञीप૑ਏऩफ़ॖॻ RNA भ੿ਛ‫ؚ‬಍ཝषभ଑ো॑
ষअ१‫ش‬অ५दघ‫؛‬ड़উ३ঙথधखथ 96 क़ख़ঝউঞ‫ॺش‬षभ಍ཝभ౐௞ृ૗౮಍ཝभ५ॡজ‫ॽش‬থॢुষःऽघ‫؛‬१‫ش‬অ५৔ઍउेलમস
x੦মউছথफ़ॖॻ RNA भਝੑफ़ॖॻ RNA भିધ಍ཝषभफ़ॖॻ RNA-Cas9 ള়৬भ଑ো
૗౮଑ো஍૨भનੳ
Total 50,000 ৞xड़উ३ঙথউছথ
96 क़ख़ঝউঞ‫ॺش‬षभ಍ཝभ౐௞ 3,000 ৞ / 1 উঞ‫ॺش‬૗౮଑ো಍ཝभ३‫ش‬ॡग़থ५ 10,000 ৞ / 8 ॡট‫ش‬থളਯभफ़ॖॻ RNA भઞ৷ 10,000 ৞१‫ش‬অ५भ૴ो
x੦মউছথ‫؝ڭ‬হ৐ৼ୥
‫؝ڮ‬ண੢છ‫ق‬஘ૄ‫كڭ‬भ઀ল‫؝گ‬फ़ॖॻ RNA भਝੑ‫ିؚ‬ધ ‫ିق‬ધ৐पଦഔ॑નੳखथःञटऌऽघ‫ك‬‫؝ڰ‬ग़ঞॡॺটএঞ‫ش‬३ঙথपेॊफ़ॖॻ RNA Cas9 भ಍ཝषभ଑ো
‫؝ڱ‬ংঝॡ३‫ش‬ॡग़থ५पेॊ૗౮଑ো஍ટभનੳ
‫؝ڲ‬಍ཝभਬऌநख

53

x

ड़উ३ঙথউছথ‫ ڭ‬96 क़ख़ঝউঞ‫ॺش‬षभ౐௞‫ق‬੦মউছথप୯ਸघॊड़উ३ঙথदघ‫ك؛‬‫؞‬७ঝ९‫॑شॱش‬৷ःथ 1 ಍ཝङण 96 क़ख़ঝউঞ‫ॺش‬ष౐௞खသു‫ؚ‬ॡট‫ش‬থ৲‫؛‬಍ཝ॑౐௞खञউঞ‫॑ॺش‬उநखखऽघ‫؛‬xड़উ३ঙথউছথ‫ ڮ‬ॡট‫ش‬থभ३‫ش‬ॡग़থ५‫ق‬੦মউছথधड़উ३ঙথউছথ 1 प୯ਸघॊड़উ३ঙথदघ‫ك؛‬‫؞‬૚ॡট‫ش‬থभ૗౮भથ૮॑३‫ش‬ॡग़থ५पेॉનੳखऽघ‫؛‬૗౮॑੅णॡট‫ش‬থ॑उநखखऽघ‫؛‬xड़উ३ঙথউছথ‫ گ‬ളਯभफ़ॖॻ RNA भઞ৷‫ق‬੦মউছথप୯ਸघॊड़উ३ঙথदघ‫ك؛‬‫؞‬૗౮଑ো஍૨॑঱ऑॊञीपളਯ‫ق‬3 णऽद‫ك‬भफ़ॖॻ RNA ॑৊ৎपઞ৷खऽघ‫؛‬उணख੢ाऽङमৣ੶उਖः়ॎच੔ऽदओ৴൪ऎटऔः‫ैँ؛‬ऊगी৯৓भ఩஫৕ౣૐऋ૭ચऊ
नअऊਫ਼ୈःञखऽघ‫؛‬जभ৏‫ؚ‬ண੢છ॑ओ੶োभअइ‫ؚ‬ว໣প৾ ৈಉଢ଼஢੹ ఐ৾ଢ଼஢੦ೕ७থॱ‫ش‬૿ਊ ෍ਉ ‫ق‬wakihara‫ٯ‬gifu-u.ac.jp‫ك‬षओଛહऎटऔः‫؛‬उਖः়ॎच੔

‫؞‬ম१‫ش‬অ५৸ಹपणःथ
।ঀ঒ଢ଼஢ী৙

ৈਣൄ௟

8

mail: staka‫ٯ‬gifu-u.ac.jp
৔଍: 3174ΰόϞฦॄࡋ๖ࡠ੔ण୙γʖϑη ਅࠒॽʤ༹ࣞ̏ʥՌָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ా ׇ࣪‬ҐԾ͹಼༲Ͷͱࡠ‫ۂ‬ण୙Νਅ͢ࠒΊΉͤɽ೧ᶅॶ଒ࣰ‫੻ݩ‬೜ं
ࢱ໌
࿊ཙ઎

Tel

Mail

ᶆ

˚ࣰ‫੻ݩ‬೜ंͳಋͣ ʤࣰ‫੻ݩ‬೜ंͳҡ͵Ζ৖߻ͺҐԾͶ‫ى‬೘ʥ‫ܨ‬ඇෝ୴ं

ॶ଒
ࢱ໌
࿊ཙ઎

Tel

Mail

ᶈ

ʤҐԾ͖Δમ୔͢ͱ͚ͫ͠͏ɽʥ

ғབϕϧϱ

˚

‫خ‬ຌϕϧϱ (಼༲ͺ 3 Ϙʖζ໪Ν͟ལ͚ͫ͠͏)˚௧ՅΨϕεϥϱ̏ʤιϩλʖνʖΝ࢘ͮͪ 1 ࡋ๖͟ͳ͹ୱ཯ʥ˚௧ՅΨϕεϥϱ̐ʤDNA εʖέΦϱηͶΓΖ֮೟ʥᶉҪఽࢢ໌Ήͪͺ gene symbol

ଲেҪఽࢢ
NCBI gene IDՌָ‫خڂݜ‬൭ιϱνʖғབ൬ߺʌʌʌʌʌʌʌ

‫ى‬೘ཟӀో͢༩ఈೖ

೧

5

݆

ೖ

୴౲ʌʌʌʌʌʌʌ

݆ೖΰόϞฦॄࡋ๖ࡠ੔ण୙γʖϑη ຌਅࠒॽʀ‫ى‬೘ྭ

ʤ༹ࣞ 1ʥ

Ռָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ా ׇ࣪‬ҐԾ͹಼༲Ͷͱࡠ‫ۂ‬ण୙Νਅ͢ࠒΊΉͤɽ೧ᶅॶ଒˕˕‫ڂݜ‬Ռ ʕʕ‫࣪ڂݜ‬ࢱ໌ΰόϞ ଢ࿢

ࣰ‫੻ݩ‬೜ं

࿊ཙ઎

Tel

̗̗̗̗

Mail ˕˕@˕˕˕˕ᶆ˛ࣰ‫੻ݩ‬೜ंͳಋͣ ʤࣰ‫੻ݩ‬೜ंͳҡ͵Ζ৖߻ͺҐԾͶ‫ى‬೘ʥ‫ܨ‬ඇෝ୴ं

ॶ଒
ࢱ໌
࿊ཙ઎

Tel

Mail

ᶈ

ʤҐԾ͖Δમ୔͢ͱ͚ͫ͠͏ɽʥ

ғབϕϧϱ

˛

‫خ‬ຌϕϧϱ (಼༲ͺ 3 Ϙʖζ໪Ν͟ལ͚ͫ͠͏)˚௧ՅΨϕεϥϱ̏ʤιϩλʖνʖΝ࢘ͮͪ 1 ࡋ๖͟ͳ͹ୱ཯ʥ˚௧ՅΨϕεϥϱ̐ʤDNA εʖέΦϱηͶΓΖ֮೟ʥᶉҪఽࢢ໌Ήͪͺ gene symbol

ଲেҪఽࢢ
NCBI gene IDՌָ‫خڂݜ‬൭ιϱνʖғབ൬ߺʌʌʌʌʌʌʌ

‫ى‬೘ཟӀో͢༩ఈೖ

೧

݆



ೖ

୴౲ʌʌʌʌʌʌʌ

݆ೖΰόϞฦॄࡋ๖ࡠ੔ण୙γʖϑηͶͯ͏ͱγʖϑη֕གྷ
ຌण୙γʖϑηͺ CRISPR/Cas9 ๑Ν༽͏ͪҪఽࢢฦॄࡋ๖͹ࡠ੣Νߨ͑γʖϑηͲͤɽΪ΢χ RNA
ʤgRNAʥ͹υδ΢ϱɼࡋ๖΃͹ gRNA, Cas9 ͹಍೘Νߨ͏ΉͤɽΉͪΨϕεϥϱγʖϑηͳ͢ͱࡋ๖͹έϫʖϱԿͳ DNA εʖέΦϱηͶΓΖรҡ͹ಋఈ΍ߨ͏Ήͤɽຌγʖϑη͹ྋۜͶͺ gRNA Ώ Cas9 ͵ʹ͹ࢾ༂ྪ΍ͤ΄ͱ‫؜‬ΊΉͤɽγʖϑη಼༲
‫خ‬ຌϕϧϱ

ʤ50,000 ԃʥʀ ਅ͢ࠒΊंͳ૮஌͹৏ɼΪ΢χ RNAʤ̸RNAʥ͹અ‫ܯ‬Νߨ͏Ήͤɽʀ ΦϪέφϫϛϪʖεϥϱ๑Ν࢘ͮͱ gRNA ͳ Cas9 Νࡋ๖಼Ͷ಍೘͢Ήͤɽʀ 1ʛ2 ೖ‫ޛ‬ͶҲ෨ࡋ๖ॄ஄͹ώϩέεʖέΦϱηΝߨ͏ҪఽࢢฦॄްՎΝ֮೟͢Ήͤɽʀ ೴඾෼ͺ gRNA ͳ Cas9 Ν಍೘ͪ͢ࡋ๖Ͳͤɽ‫خ‬ຌదͶͺക཈Ծ͹ࡋ๖ΝϓϧηαͶ೘Ηͱ͕ో͢͢
Ήͤɽ͟‫س‬๮ͶԢͣͱྮ౜ฯଚͪ͢΍͹Ν͕ో͢͢Ήͤʤ+500 ԃʥɽΨϕεϥϱγʖϑηΨϕεϥϱγʖϑη̏ʁࡋ๖͹έϫʖϱԿ

ʤ3,000 ԃʥʀ ιϩλʖνʖΝ࢘ͮͱ 96 ΤΥϩϕϪʖφ΃ 1 ࡋ๖/ΤΥϩͲୱ཯͢Ήͤɽʀ ೴඾෼ͺ 96 ΤΥϩϕϪʖφʤ‫س‬๮ͶΓΕ 1 ທΉͪͺ 2 ທʥͳ࢔Ε͹ࡋ๖Ͳͤɽʀ ࢔Ε͹ࡋ๖Ͷͯ͏ͱͺക཈Ծ͹΍͹ΝϓϧηαͶ೘Ηͱ͕ో͢͢Ήͤɽ͟‫س‬๮ͶԢͣͱྮ౜ฯଚͪ͢
΍͹Ν͕ో͢͢Ήͤʤ+500 ԃʥɽΨϕεϥϱγʖϑη̐ʁέϫʖϱԿࡋ๖͹ DNA εʖέΦϱη

ʤ10,000 ԃʥʀ έϫʖϱԿͪ͢ࡋ๖Ν 8 έϫʖϱࡀख͢ DNA εʖέΦϱηͶΓΕഓ྽Νಋఈ͢Ήͤɽʀ ೴඾෼ͺ֦έϫʖϱࡋ๖Ͳͤʤʹ͹έϫʖϱ͖Ν͟ࢨఈԾ͠͏ʥ
ɽʀ ക཈Ծ͹΍͹ΝϓϧηαͶ೘Ηͱ͕ో͢͢Ήͤɽ͟‫س‬๮ͶԢͣͱྮ౜ฯଚͪ͢΍͹Ν͕ో͢͢Ήͤ
ʤ+500 ԃ/έϫʖϱʥɽʀ ຌΨϕεϥϱͶͺΨϕεϥϱγʖϑη̏͹ਅ͢ࠒΊ͗චਤͲͤɽ

͕໲͏߻Κͦ઎ʀਅࠒॽૻ෉઎
‫ز‬෠୉ָ ߶౵‫ڂݜ‬ӅՌָ‫خڂݜ‬൭ιϱνʖ ‫خڂݜ‬൭֋൅ਬ਒౹‫ׇ࣪‬߶ౣໞ༦ mail: stakaˑgifu-u.ac.jp
಼ત: 31746ว໣প৾ ৈಉଢ଼஢੹

ఐ৾ଢ଼஢੦ೕ७থॱ‫ ش‬ଢ଼஢੦ೕ৫৅௓ਤଁฐ஼

௒ਪ஑ਗ਼৕ႀ๶ྰ ਭ౏ীෲ१‫ش‬অ५१‫ش‬অ५໪ਏ

௒ਪ஑ਗ਼৕ႀ๶ྰ௴௄भਭ౏ীෲ१‫ش‬অ५॑ষःऽघ‫௴؛‬௄৷૥મभ੿ਛऊैਗ਼৕ႀ๶ྰद
भ઺൸਄੭ऽद঳৴भੵங॑ओൂ౅ःञटऐऽघ‫؛‬಍ཝृੌ௶ऩनभে৬१থউঝमपणः
थम૑ਏपૢगथಕ৒‫ؚ‬൓਷ಉभ৐૪৶॑ষःऽघ‫؛‬ে৬૥મਰਗभ१থউঝु૑ਏऩੵங
भाभમসदउਭऐःञखऽघ‫؛‬‫پ‬૥ఇभභোमਂਏदघ‫؛‬ड़উ३ঙথधखथ಍ཝသുृজঔ‫௴ॺش‬௄ुओൂ౅ःञटऐऽघ‫؛‬१‫ش‬অ५৔ઍ
x੦মউছথ ੵஙउेलમস (1 १থউঝभाभৃ়)१থউঝभ৐ಕ৒ ‫ق‬੦ম৓पऒभ૾ଙद१থউঝ॑उநखऎटऔः‫ك‬৏ಕ৒ (٧1000)ग़ॱঀ‫ش‬ঝ௺ഔपेॊ൓਷, t-ঈॱঀ‫ش‬ঝ࿠კ, ইজ‫ش‬६ॻছॖ૪৶ (٧2000)
ड़५঑क़঒॥‫ॸش‬ॕথॢ (٧2000)
௒ਪ஑ਗ਼৕ႀ๶ྰपेॊ௴௄‫୼؞‬ઌ๡୶ (٧1000)
Total 6000 ৞‫્ٮ‬৒भੵஙभाभओൂ౅ु૭ચदघ‫؛‬

7

x

મসถ಍
ᩱ㔠 2*

ᕤ⛬

ᩱ㔠 1

ᚋᅛᐃ

䢠1,000 (1 䝃䞁䝥䝹┠) 䢠500 (2䡚4 䝃䞁䝥䝹┠)⬺Ỉ䞉䝣䝸䞊䝈䝗䝷䜲ฎ⌮ 䢠2,000 (1 䝃䞁䝥䝹┠) 䢠1,000 (2䡚4 䝃䞁䝥䝹┠)䜸䝇䝭䜴䝮䝁䞊䝔䜱䞁䜾

䢠2,000 (1 䝃䞁䝥䝹┠) 䢠1,000 (2䡚4 䝃䞁䝥䝹┠)ほᐹ䢠1,000 (䝃䞁䝥䝹)‫௴ٮ‬௄ਰਗभੵஙमਈপ 4 १থউঝङण૪৶घॊञी१থউঝਯदમসऋ౮ऩॉऽघ‫؛‬xड़উ३ঙথ
಍ཝသു(٧2000/4 १থউঝऽद৊঳મস)জঔ‫௴ॺش‬௄‫ق‬૮મ‫ك‬
WebEX ॑ઞढञজঔ‫ॺش‬भজ॔ঝॱॖ঒௴௄ऋ૭ચदघ‫؛‬जभ౎્શऩ૪৶ऋ૑ਏऩৃ়मৣ੶उਖः়ॎच੔ऊैओৼ୥ऎटऔः‫؛‬१‫ش‬অ५भ૴ो

੦মউছথ‫؝ڭ‬ও‫ش‬ঝ, HP ऽञमउਗ਼ਵदभओൂ౅‫؛‬‫ ڀ ঻౅ൂق‬७থॱ‫كپش‬‫؝ڮ‬१থউঝ఺लੵஙभનੳ
‫঻౅ൂق‬, ७থॱ‫كش‬‫؝گ‬ண੢છ‫ق‬஘ૄ 1‫ك‬भ઀ল‫ ڀ ঻౅ൂق‬७থॱ‫كش‬‫؝ڰ‬१থউঝਭऐநख঩ஙभ৹ତ
‫঻౅ൂق‬, ७থॱ‫كش‬‫ق؝ڱ‬१থউঝऋ಍ཝभৃ়भा‫ك‬သു৷ீ஑ढ़ং‫ॢش‬ছ५, သുউঞ‫ॺش‬भଛહ૑ਏपૢगथ৐ಕ৒ัभଛહ
‫ق‬७থॱ‫ك঻౅ൂ ڀ ش‬‫؝ڲ‬१থউঝभಕ৒
‫঻౅ൂق‬ऽञम७থॱ‫كش‬‫؝ڳ‬१থউঝभਭऐநख‫ ڀ ঻౅ൂق‬७থॱ‫كش‬‫؝ڴ‬৏ಕ৒‫ؚ‬൓਷‫ؚ‬ইজ‫ش‬६ॻছॖಉभ૪৶
‫ق‬७থॱ‫ك঻౅ൂ ڀ ش‬‫௴؝ڵ‬௄঩ஙभ৹ତ
‫঻౅ൂق‬, ७থॱ‫كش‬‫؝ڬڭ‬ड़५঑क़঒॥‫ॸش‬ॕথॢ‫ق‬७থॱ‫كش‬‫௴؝ڭڭ‬௄‫୼؞‬ઌ๡୶७থॱ‫ش‬, ૑ਏपૢगथൂ౅঻৊ఆ, ऽञमজঔ‫௴ॺش‬௄‫ك‬‫ॱشॹ؝ڮڭ‬ध१থউঝभଛહ
‫ق‬७থॱ‫ك঻౅ൂ ڀ ش‬‫پ‬७থॱ‫ ؟ش‬ว໣প৾ ৈಉଢ଼஢੹ ఐ৾ଢ଼஢੦ೕ७থॱ‫ ش‬ଢ଼஢੦ೕ৫৅௓ਤଁฐ஼



ணख੢ा

ऽङमৣ੶उਖः়ॎच੔पओ৴൪ःञटऌ‫ؚ‬१থউঝभถ಍॑उੴैचऎटऔः‫؛‬ম१‫ش‬অ५ऋి৷૭ચऊनअऊ॑ਫ਼ୈखञखऽघ‫؛‬जभ৏ਰৣभண੢છ॑ओ੶োभअइ‫ؚ‬ว໣প৾ ৈಉଢ଼஢੹ ఐ৾ଢ଼஢੦ೕ७থॱ‫ش‬૿ਊ ૕ি ‫ق‬y_sawada@gifu-u.ac.jp‫ك‬षओଛહऎटऔः‫؛‬उਖः়ॎच੔

‫؞‬ম१‫ش‬অ५৸ಹपणःथ
ఐ৾ଢ଼஢੦ೕ७থॱ‫ش‬ਃஓীෲী৙ ૕ি mail: y_sawada@gifu-u.ac.jp
৔଍: 2035‫؞‬ে੟૥મभ૪৶ಉपणःथ
ఐ৾ଢ଼஢੦ೕ७থॱ‫ش‬।ঀ঒ଢ଼஢ী৙ ৈਣ mail: staka@gifu-u.ac.jp
৔଍: 3174

 0㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾ཷクศᯒࢧ࣮ࣅࢫ
⏦㎸᭩ 㸦ᵝᘧ 1㸧౫㢗⪅グධ᪥䠄すᬺ䛷䛚㢪䛔䛧䜎䛩䠅䠖Ặྡ䠖ᡤᒓᏛ㒊䞉Ꮫ⛉➼䠖㐃⤡ඛ㟁ヰ␒ྕ䠖㐃⤡ඛ e-mail 䜰䝗䝺䝇䠖⤒ ㈝ ㈇ ᢸ ⪅ 䠄 ⏦ ㎸ ⪅ 䛸ྠ 䛨ሙ ྜ 䛿௨ ୗ グ ධ ୙ せ 䠅Ặྡ䠖ᡤᒓᏛ㒊䞉Ꮫ⛉➼䠖㐃⤡ඛ㟁ヰ␒ྕ䠖㐃⤡ඛ e-mail 䜰䝗䝺䝇䠖ᥦ ฟ 䝃䞁䝥䝹䛻䛴䛔䛶䝃䞁䝥䝹䛾⡆༢䛺ㄝ᫂䜢䛚᭩䛝䛟䛰䛥䛔䚹䝃䞁䝥䝹䛾≧ែ 䠄䠅䠍. ᅛᐃ䛜ᚲせ䛺⏕≀⤌⧊䞉⣽⬊䠄౛䠖ᇵ㣴⣽⬊䚸ゎ๗⤌⧊䠅䠎. ᅛᐃ୙せ䛾⏕≀⤌⧊䞉⣽⬊䠄౛䠖᪻⹸䚸ⴥ䚸ᮌ∦䚸㧥䛾ẟ䠅䠏䠊㠀⏕≀ 䠄䜾䝷䝇䝣䜯䜲䝞䞊䚸ᶞ⬡䚸㔠ᒓ䚸㖔≀ ➼䠅
ಶᩘ (

)

 1

ᕼ ᮃ 䝃䞊䝡䝇ෆ ᐜ 䠄 ᚲ せ 䛺䜒䛾䛻䚽䠅ᚋᅛᐃ⬺Ỉ䞉䝣䝸䞊䝈
䝗䝷䜲ฎ⌮(䜾䝹䝍䞊䝹䜰䝹䝕䝠䝗)䜸䝇䝭䜴䝮䝁䞊䝔䜱䞁䜾ほᐹほ ᐹ 䛸෗ ┿ ᧜ ᙳ 䛻䛴䛔䛶㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾䛷䛾ほᐹ䛸෗┿᧜ᙳ䛻㛵䛩䜛䛤ᕼᮃ䜢䛤グධ䛟䛰䛥䛔䚹䛤ᕼᮃෆᐜ 䠄䠅䠍䠊⿦⨨⬥䛻ྠᖍ䛧ほᐹ䛸෗┿᧜ᙳ䛾ᣦ♧䜢⾜䛖䚹
䠎䠊Web 䝭䞊䝔䜱䞁䜾䝅䝇䝔䝮䛷䛾䝸䝰䞊䝖ほᐹ䛸᧜ᙳ䛾ᣦ♧䜢⾜䛖䚹䠏䠊ほᐹ䛸෗┿᧜ᙳ䛿䝉䞁䝍䞊ഃ䛾᧯స⪅䛻௵䛫䜛䚹ഛ⪃䛭䛾௚㐃⤡஦㡯䛜䛒䜚䜎䛧䛯䜙䚸䛤グධ䛟䛰䛥䛔䚹ᥦฟඛ⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊 ᶵჾศᯒศ㔝 ᢸᙜ䠖ἑ⏣E-mail: y_sawada䠜gifu-u.ac.jp

ෆ⥺: 2035 2
ࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : @gifu-u.ac.jp
TEL : 058-293-┠࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

‫࢕ࢸࣜࢩ࢓ࣇ࢔ࢥ ی‬ᶵჾඹ⏝㐃ᦠᐊ㛗ᣵᣜ


⤌⧊

ḟ

 ἢ㠉
 ᩍ⫋ဨ ༠ຊဨ࣭༠ຊ⿵ຓဨ
ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ༠ຊဨ࡟㛵ࡍࡿ⏦ࡋྜࢃࡏ⾲  ༠ຊဨྡ⡙ᶵჾ⤂௓࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ᶵჾ୍ぴ ᶵჾᴫせ฼⏝ࡢᡭᘬࡁ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

 ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ฼⏝ࡢᡭ㡰 ィ ᶵჾࡢ฼⏝࡟㛵ࡍࡿ⏦ࡋྜࢃࡏู⾲  ฼⏝⪅㈨᱁
ู⾲  ᶵჾ฼⏝⏦ㄳ᭩ู⾲  ᫬㛫እ฼⏝ᒆ ཷクヨ㦂࡟ࡘ࠸࡚ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾ
ඹ⏝㐃ᦠᐊཷクヨ㦂ࠊ ᐃཬࡧ᳨ᰝ➼ྲྀᢅせ㡿ู⾲ ཷクヨ㦂➼ࡢᇶᮏ฼⏝ᩱ㔠ཷクヨ㦂➼ࡢᡭ⥆ࡁู⣬ᵝᘧ➨  ྕ ཷクヨ㦂౫㢗᭩ู⣬ᵝᘧ➨  ྕ ᶵჾ➼౑⏝⏦ㄳ᭩άືሗ࿌࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭ ฼⏝⪅◊✲ㄽᩥ୍ぴ ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊᩍဨࡢᩍ⫱࣭◊✲άື➼‫࢕ࢸࣜࢩ࢓ࣇ࢔ࢥ ی‬ᶵჾඹ⏝㐃ᦠᐊ㛗ᣵᣜࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ㛗㙊㊊ 㞝ྖᏛෆእ䛾◊✲⪅䛾ⓙᵝ䛻䛿᪥㡭䜘䜚ᶵჾศᯒศ㔝䝁䜰䝣䜯䝅䝸䝔䜱ᶵჾඹ⏝㐃ᦠᐊ䛾◊✲ᇶ┙䚸ཷクゎᯒ䜢䛤฼⏝㡬䛝䛒䜚䛜䛸䛖䛤䛦䛔䜎䛩䚹ᨻᗓ䛾◊✲㛤Ⓨᢞ㈨䛾ఙ䜃䛜೵⁫䛧䛶䛔䜛୰䚸◊✲㛤Ⓨᢞ㈨䛾ຠᯝ䜢᭱኱໬䛧䚸᭱ඛ➃䛾◊✲⌧ሙ䛻䛚䛔䛶◊✲ᡂᯝ䜢ᣢ⥆ⓗ䛻๰ฟ䛧䚸」㞧໬䛩䜛᪂䛯䛺Ꮫၥ㡿ᇦ䛺䛹䛻ᑐᛂ䛧䛶䛔䛟䛯䜑䛻䛿䚸◊✲タഛ䞉ᶵჾ䛾ඹ⏝໬䜢᭦䛻ಁ㐍䛧䛶䛔䛟䛣䛸䛜୙ྍḞ䛷䛩䚹䛣䛾䛯䜑䛾஦ᴗ䚸ඛ➃◊✲ᇶ┙ඹ⏝ಁ㐍஦ᴗ䠄᪂䛯䛺ඹ⏝䝅䝇䝔䝮ᑟධᨭ᥼䝥䝻䜾䝷䝮䠅䛻䚸ᒱ㜧኱Ꮫ䛿ᖹᡂ 30 ᖺᗘ᥇ᢥ䛥䜜ඹ⏝᥎㐍ᨭ᥼䝉䞁䝍䞊䛜Ⓨ㊊䛧䜎䛧䛯䚹஦ᴗ⤊஢ᚋ䚸ඹ⏝᥎㐍ᨭ᥼䝉䞁䝍䞊䛾୺せ䛺ᶵჾ䛿䚸䝛䝑䝖䝽䞊䜽ᆺඹ⏝ᨭ᥼ᐊ䜢⤒䛶䚸⌧ᅾᶵჾศᯒศ㔝䝁䜰䝣䜯䝅䝸䝔䜱ᶵჾඹ⏝㐃ᦠᐊ䜈ᘬ䛝⥅䛜䜜䛶䛔䜎䛩䚹䝁䜰䝣䜯䝅䝸䝔䜱ᶵჾඹ⏝㐃ᦠᐊ䛿䚸Ꮫෆ䛾ඛ➃◊✲タഛ䜢ඹྠ฼⏝䝛䝑䝖䝽䞊䜽䛸䛧䛶⤌⧊䛧䚸Ꮫෆእ䛾ᩍ⫱䞉◊✲䛻ᥦ౪䛩䜛⤌⧊䛷䛩䚹䜎䛯䚸ཷクヨ㦂ไᗘ䜔ඹྠ◊✲䝥䝻䝆䜵䜽䝖䛾᥎㐍䜢㏻䛨䚸ᆅᇦ䛻ᗈ䛟㈉⊩䛧䜎䛩䚹䛣䜜䛛䜙䜒䚸฼⏝⪅䛾ⓙᵝ䛾◊✲䛾Ⓨᒎ䛻ᐤ୚䛷䛝䜎䛩䜘䛖䚸༠ຊဨ䛾ඛ⏕᪉䛾䛤ᨭ᥼䜢㈷䜚䛺䛜䜙䚸ᙜᐊ䜢㐠Ⴀ䛧䛶䛔䛟ᡤᏑ䛷䛩䚹௒ᚋ䛸䜒䛹䛖䛮䜘䜝䛧䛟䛚㢪䛔⏦䛧ୖ䛢䜎䛩䚹

 3

㸯

⤌⧊

1. ἢ㠉
ᖹᡂ 30 ᖺᗘ ඛ➃◊✲ᇶ┙ඹ⏝ಁ㐍஦ᴗ㸦᪂ࡓ࡞ඹ⏝ࢩࢫࢸ࣒ᑟධᨭ᥼ࣉࣟࢢ࣒ࣛ㸧᥇ᢥ࡟క࠸ࠊ
ඹ⏝᥎㐍ᨭ᥼ࢭࣥࢱ࣮Ⓨ㊊ࠋ
௧࿴ 2 ᖺᗘ ᮾᾏᅜ❧኱ᏛᶵᵓࡢⓎ㊊࡟క࠸ࠊᒱ㜧኱Ꮫ㧗➼◊✲㝔࡟ᡤᒓࠋ௧࿴ 3 ᖺᗘ ඹ⏝᥎㐍ᨭ᥼ࢭࣥࢱ࣮࠿ࡽ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࡬⛣⟶࡟ࡼࡾࠊࢿࢵࢺ࣮࣡ࢡᆺඹ⏝ᨭ᥼ᐊࢆタ⨨ࠋ௧࿴ 4 ᖺᗘ ࢿࢵࢺ࣮࣡ࢡᆺඹ⏝ᨭ᥼ᐊ࠿ࡽᶵჾศᯒศ㔝ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ࡬⛣⟶ࠋ

2. ᩍ⫋ဨ

㸦㸧ෆࡣෆ⥺␒ྕ

(1) ᑓ௵ᩍဨຓᩍ

㙊㊊ 㞝ྖ㸦3900㸧

3. ༠ຊဨ࣭༠ຊ⿵ຓဨ
ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ༠ຊဨ࡟㛵ࡍࡿ⏦ࡋྜࢃࡏ㸦㊃᪨㸧➨㸯᮲ ࡇࡢ⏦ࡋྜࢃࡏࡣࠊᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㸦௨ୗࠕࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ
㸧ᶵჾศᯒศ㔝࡟⨨ࡃࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ༠ຊဨ㸦௨ୗࠕ༠ຊဨࠖ࡜࠸࠺ࠋ㸧࡟㛵ࡋࠊᚲせ࡞஦㡯ࢆᐃࡵࡿࠋ㸦ᐃ⩏㸧➨㸰᮲ ༠ຊဨࡣࠊࢭࣥࢱ࣮ࡢࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊࡀ⟶⌮ࡍࡿᶵჾཬࡧタഛ㸦௨ୗࠕᶵჾ➼ࠖ࡜࠸࠺ࠋ
㸧ࢆࠊ㈐௵ࢆࡶࡗ࡚⟶⌮ࠊ㐠⏝ࠊࡲࡓࡣࠊྲྀᢅ࡟࠶ࡓࡿࡇ࡜ࡀ࡛ࡁࡿ⪅࡜ࡍࡿࠋ㸦⤌⧊㸧➨㸱᮲ ༠ຊဨࡣࠊᶵჾࡈ࡜࡟⨨ࡁࠊࢭࣥࢱ࣮㛗ࡀ᥎⸀ࡍࡿᒱ㜧኱Ꮫࡢᑓ௵ࡢᩍဨࢆࡶࡗ࡚඘࡚ࠊᏛ
㛗ࡀጤკࡍࡿࠋ
㸦㈐௵⪅㸧➨㸲᮲ ༠ຊဨࡢ஫㑅࡟ࡼࡾᢸᙜࡍࡿᶵჾࡈ࡜ࡢ㈐௵⪅㸦௨ୗࠕ㈐௵⪅ࠖ࡜࠸࠺ࠋ㸧ࢆ㑅ฟࡍࡿࠋ㸦௵ົ㸧➨㸳᮲ ༠ຊဨࡣࠊࢭࣥࢱ࣮ࡢᩍ⫋ဨ࡜༠ຊࡋ࡚ḟࡢෆᐜࢆ༠㆟ࡋࠊᴗົࢆ⾜࠺ࠋձᶵჾ➼ࡢཎ⌮࣭౑⏝ἲ࡟㛵ࡍࡿㅮ⩦఍➼࡟㛵ࡍࡿࡇ࡜ࠋ

ղᶵჾ➼ࡢ⥔ᣢ⟶⌮࡟㛵ࡍࡿࡇ࡜ࠋ

ճᶵჾ➼ࡢ౑⏝ἲ➼┦ㄯ࡟㛵ࡍࡿࡇ࡜ࠋ

մࡑࡢ௚ࠊᶵჾ➼ࡢ෇⁥࡞㐠⏝࡟㛵ࡍࡿࡇ࡜ࠋ

8

㸦௵ᮇ㸧
➨㸴᮲ ༠ຊဨࡢ௵ᮇࡣ஧ᖺ࡜ࡋࠊ෌௵ࢆጉࡆ࡞࠸ࠋ㸦⿵ຓဨ㸧➨㸵᮲ ༠ຊဨࡢᴗົࢆ⿵ຓࡍࡿࡓࡵ࡟ࠊ༠ຊဨ⿵ຓဨ㸦௨ୗࠕ⿵ຓဨࠖ࡜࠸࠺ࠋ
㸧ࢆ⨨ࡃࡇ࡜ࡀ࡛ࡁ
ࡿࠋ㸰⿵ຓဨࡣࠊ༠ຊဨࡢᴗົ࡬ࡢ⿵ຓࡀᚲせ࡞ᶵჾࡈ࡜࡟⨨ࡁࠊࢭࣥࢱ࣮㛗ࡀ᥎⸀ࡍࡿ⪅ࢆࡶࡗ࡚඘
࡚ࠊᏛ㛗ࡀጤკࡍࡿࠋ

㸱⿵ຓဨࡢ௵ᮇࡣ஧ᖺ࡜ࡋࠊ෌௵ࢆጉࡆ࡞࠸ࠋ

⾲ 1. ༠ຊဨྡ⡙ 㸦‫۔‬㸸ᶵჾྲྀᢅ㈐௵⪅ࠊ*㸸༠ຊ⿵ຓဨ㸧
ᶵ

ჾ

ྡ

Ặ

㧗㍤ᗘ㹖⥺ᅇᢡ⿦⨨ (XRD)
SmartLab 9kW㟁⏺ᨺᑕᆺ㏱㐣㟁Ꮚ㢧ᚤ㙾 (TEM)
JEM2100FGK⏕యศᏊ㛫┦஫స⏝ゎᯒࢩࢫࢸ࣒ (SPR)
Biacore T200

5

R4. 5. 1
ྡ

㟁ヰ␒ྕ

㒊

ᒁ

‫۔‬኱ᶫ ྐ㝯
ྜྷ⏣ ᠇඘
ᒣ⏣ ၨ௓
すὠ ㈗ஂ

2686
2683
2819
2888

ᕤᏛ㒊
ᕤᏛ㒊
ᕤᏛ㒊
ᛂ⏝⏕≀⛉Ꮫ㒊‫۔‬኱▮ ㇏
⸨⃝ ဴ㑻
ụ⏣ ᑗ
༓⏣ 㝯ኵ

2589
2595
2639
6294

ᕤᏛ㒊
ᕤᏛ㒊
ᕤᏛ㒊
་Ꮫ◊✲⛉

‫۔‬ᒣෆ ᜏ⏕ᾏ⪁ཎ ❶㑻
஧ᮧ Ꮫ
ᶓᕝ 㝯ᚿ

2897
2907
7858
2644

ᛂ⏝⏕≀⛉Ꮫ㒊ᛂ⏝⏕≀⛉Ꮫ㒊
་Ꮫ◊✲⛉
ᕤᏛ㒊

2

ᶵჾ⤂௓

1.

ᶵჾ୍ぴ

⾲ 2-1-2. ᶵჾ㓄⨨ሙᡤࠊ⣡ධᖺᗘࠊつ᱁ᶵჾྡࠊ࠾ࡼࡧࠊᶵჾ㓄⨨ሙᡤ
㧗㍤ᗘ㹖⥺ᅇᢡ⿦⨨ (XRD)⥲ྜ◊✲Ჷϩ 1 㝵 ᶵჾศᯒᐊ(7)㟁⏺ᨺᑕᆺ㏱㐣㟁Ꮚ㢧ᚤ㙾 (TEM)་Ꮫ㒊⥲ྜᲷ 7 㝵 7N16
⏕యศᏊ㛫┦஫స⏝ゎᯒࢩࢫࢸ࣒ (SPR)⥲ྜ◊✲Ჷϩ 1 㝵 ᶵჾศᯒᐊ(3)

2.

⣡ධᖺᗘ

つ

H30 ᖺᗘ

ࣜ࢞ࢡ SmartLab 9kW

H20 ᖺᗘ

JEOL JEM2100FGK

H18 ᖺᗘ

Cytiva Biacore T200ᶵჾᴫせ

㧗㍤ᗘ㹖⥺ᅇᢡ⿦⨨ (XRD) SmartLab ࡣࠊⓎᩓࣅ࣮࣒࣭ᖹ⾜ࣅ࣮࣒࣭㞟ගࣅ࣮࣒ࡢษࡾ᭰࠼ࡀᐜ࡛᫆࠶ࡾࠊ᥋ゐᆺࢥࢿࢡࢱ᪉ᘧ᥇⏝࡟ࡼࡾࠊᐃ┠ⓗ࡟ᛂࡌ࡚ࣘࢽࢵࢺࢆ஺᥮ࡍࡿࡔࡅ࡛ࠊࢧࣥࣉࣝ᝟

ሗ࡟ᇶ࡙ࡁගᏛ⣲Ꮚࡸᐃ᮲௳ࡀタᐃࡉࢀࠊィࡲ࡛ࡢ୍㐃ࡢࣉࣟ

ࢭࢫࡀࢲ࢖࢔ࣟࢢ࣎ࢵࢡࢫ࡟ࡼࡾᥦ♧ࡉࢀࡿࠋ౛࠼ࡤࠊᑐᛂⷧ⭷ホ౯࢔ࣉࣜࢣ࣮ࢩ࡛ࣙࣥࡣࠊ⤌ᡂศᯒࠊ᪉఩࣭㓄ྥศᯒࠊ⤖ᬗᛶホ౯ࠊ᱁Ꮚ⦆࿴ホ౯ࠊ᱁Ꮚṍ࣭ṧ␃ᛂຊホ౯ࠊ⭷ཌศᯒࠊ⏺㠃ࣛࣇࢿࢫศᯒࠊᐦᗘศᯒࠊ㠃ෆᆒ୍ᛶホ౯࡞࡝ࡀࠊ✀⢊ᮎ࢔ࣉࣜࢣ࣮ࢩࣙ
࡛ࣥࡣᐃᛶศᯒࠊᐃ㔞ศᯒࠊ⤖ᬗ໬ᗘホ౯ࠊ⤖ᬗᏊࢧ࢖ࢬ/᱁Ꮚṍホ౯ࠊ᱁Ꮚᐃᩘࡢ⢭ᐦ໬ࠊRietveld ゎᯒ࡞࡝ࡀ⾜࠼ࡿࠋ㟁⏺ᨺᑕᆺ㏱㐣㟁Ꮚ㢧ᚤ㙾 (TEM) JEM2100FGK ࡣࠊࢩࣙࢵࢺ࢞
ࣥࢱ࢖ࣉ㟁⏺ᨺᑕᆺ㟁Ꮚ㖠ࢆᦚ㍕ࠋຍ㏿㟁ᅽࡣࠊ80, 100, 120, 160,
200kV ࡟ྍኚ(㏻ᖖࡣ 200kV ࡛㐠⏝)ࠋᾮయ❅⣲ᗘ(<-196Υ)ࡢ෭༷

ヨᩱࢫࢸ࣮ࢪࢆ౑⏝ྍ⬟ࠋࢱࣥࣃࢡ㉁ࡢịໟᇙヨᩱ࡟᭱㐺໬ࡉࢀࡓᑐ≀ࣞࣥࢬࢆᦚ㍕ࠋ୍⯡ⓗ࡞⏕య㛵㐃ヨᩱ࡟ࡶᑐᛂࠋගᏛ⣔ࡣ࢜ࣥࢢࢫࢺ࣮࣒࣮ࣟ࢜ࢲ࣮ࡢศゎ⬟ࠋᣑ኱ቑࡢ࡯࠿ࠊ㟁Ꮚ⥺ᅇᢡീࡶ᧜
ᙳྍ⬟ࠋ㟁Ꮚ⥺⏝ CCD ࣓࢝ࣛ࡟ࡼࡾࠊ᧜ᙳ⏬ീࢆࢹࢪࢱࣝࢹ࣮ࢱ
࡜ࡋ࡚ྲྀᚓࠋྲྀᚓ⏬ീࢹ࣮ࢱ࡟ᑐࡋࠊ஧ḟඖࣇ࣮࢚ࣜኚ᥮࡞࡝ྛ✀ゎᯒฎ⌮ࡀྍ⬟ࠋ᭱኱±80°ࡲ࡛ࡢヨᩱഴᩳ࡟ᑐᛂࡋࠊ㟁Ꮚ⥺ࢺࣔࢢࣛࣇ࢕࣮ࢩࢫࢸ࣒ࢆᦚ㍕ࠋ୕ḟඖ෌ᵓᡂࠊࢧ࣮ࣇ࢙ࢫࣞࣥࢲࣜࣥ
ࢢࠊ࣮࣒࣎ࣜࣗࣞࣥࢲࣜࣥࢢ࡟ᑐᛂࠋ

᱁⏕యศᏊ㛫┦஫స⏝ゎᯒࢩࢫࢸ࣒ (SPR) Biacore T200 ࡣࠊศᏊ㛫┦஫స⏝ࢆ฼⏝ࡋࡓ

ᐃࡢ All-in-one ࢩࢫࢸ࣒࡛ࠊࣇࣞ࢟ࢩࣈࣝ࠿

ࡘከᵝ࡞࢔ࣉࣜࢣ࣮ࢩࣙࣥ࡟ᑐᛂࡋ࡚࠸ࡿࠋ㧗࠸ឤᗘ࡜ࡉࡲࡊࡲ࡞
௜ຍᶵ⬟ࢆ᭷ࡋ࡚࠾ࡾࠊ㸯ྎ࡛ศᏊ㛫┦஫స⏝ࡢ≉␗ᛶࠊ࢔ࣇ࢕ࢽ
ࢸ࢕࣮ࠊ࢝࢖ࢿࢸ࢕ࢡࢫࠊ⃰ᗘᐃࠊపศᏊ໬ྜ≀ᐃ࠾ࡼࡧච␿

ཎᛶヨ㦂ࡀྍ⬟ࠋ┦஫స⏝࣓࢝ࢽࢬ࣒ࡢゎ᫂࡟ᚲせ࡞ࢧ࣮ࣔࢲ࢖ࢼ
࣑ࢡࢫࣃ࣓࣮ࣛࢱ࣮ࡶᚓࡿࡇ࡜ࡀ࡛ࡁࡿࠋ



3

฼⏝ࡢᡭᘬࡁ

1. ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ฼⏝ࡢᡭ㡰฼⏝⪅Ⓩ㘓฼⏝ணᐃ⪅㸦฼⏝⪅㈨᱁࡟ࡘ࠸࡚ࡣ  ࡢู⾲ 1 ࢆࡈཧ↷ୗࡉ࠸ࠋ㸧࡟ᶵჾ฼⏝ㅮ⩦఍ཧຍ⏦ࡋ㎸ࡳ᭩ཬࡧᶵჾ฼⏝⏦ㄳ᭩㸦 ࡢู⾲ 2㸧ࢆᥦฟࡋ࡚࠸ࡓࡔࡁࡲࡍࠋ
Ў฼⏝⪅ㅮ⩦఍
ᐃᶵჾࢆึࡵ࡚౑ࢃࢀࡿ᪉࡟ࡣ୺࡟ 4 ᭶࠿ࡽ 6 ᭶࡟࠿ࡅ࡚⾜࠺฼⏝⪅ㅮ⩦఍ࢆཷㅮࡋ࡚㡬ࡁࡲࡍࠋЎ฼⏝ࡢ⏦ࡋ㎸ࡳ᪥᫬ࢆࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ⫋ဨ࡟┦ㄯࡢ࠺࠼ࠊ

ᐃᕼᮃ᪥ࢆỴᐃ࠸ࡓࡋࡲࡍࠋ

Ў⿦⨨ࡢ฼⏝ཎ๎࡜ࡋ࡚฼⏝⪅ࡀ⮬ࡽᐃᶵჾࢆ㐠㌿࣭᧯సࡋ࡚࠸ࡓࡔࡁࡲࡍࠋ᫬㛫እࡢ฼⏝㸦ኪ㛫࠾ࡼࡧᅵ᪥㸧ࢆᕼᮃࡍࡿேࡣ᫬㛫እ฼⏝ᒆࢆࡈᥦฟࡃࡔࡉ࠸ࠋЎ㐠㌿᪥ㄅ฼⏝⪅ࡀᐇ㝿ࡢ฼⏝᫬㛫ࠊ฼⏝≧ἣࢆᐃᶵჾ࡟ഛ࠼௜ࡅࡢグ㘓⡙࡟グධࡋ࡚ࡃࡔࡉ࠸ࠋ୓୍ࠊ ᐃᶵჾࢆ◚ᦆࡋࡓሙྜࠊ࠶ࡿ࠸ࡣࠊ␗ᖖࢆㄆࡵࡓሙྜࡣࡓࡔࡕ࡟ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ⫋ဨ࡟㐃⤡ࡋ࡚ࡃࡔࡉ࠸ࠋ

‫⏦ࡢࢀࡒࢀࡑ ۍ‬㎸ࡳ⏝⣬ࡣࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ࣮࣒࣮࣍࣌ࢪ࡟ᥖ㍕ࡋ࡚࠶ࡾࡲࡍࠋ‫ྛ ۍ‬ᶵჾࡢ౑⏝ࡢ㝿ࡣࠊ⿦⨨࡟ഛ࠼௜ࡅࡢ⡆࣐᫆ࢽࣗ࢔ࣝࢆࡈཧ↷ୗࡉ࠸ࠋ‫ྛ ۍ‬ᶵჾࡢ౑⏝ᚋࠊᶵჾࡢ≧ែ࡟ࡘ࠸࡚Ẽࡀ௜࠸ࡓࡇ࡜ࡀ࠶ࡾࡲࡋࡓࡽࠊᶵჾࣀ࣮ࢺ࡟グ㍕ࡋ࡚ࡃࡔࡉ࠸ࠋ‫ ۍ‬ၥ࠸ྜࢃࡏ
ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊࡢ฼⏝ᡭ㡰࡟㛵ࡍࡿ㉁ၥ
ĺࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊᩍဨ࠾ࡼࡧ⫋ဨ࡟ࡈ┦ㄯୗࡉ࠸ࠋ

ᶵჾ࡟㛵ࡍࡿ㉁ၥ㸦඲⯡㸧ĺࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊᩍဨ࠾ࡼࡧ⫋ဨ࡟ࡈ┦ㄯୗࡉ࠸ࠋ

ᶵჾࡢ⣽࠿࠸ ᐃࡢࣀ࢘ࣁ࣭࢘౑⏝ᡭ㡰➼ Ѝࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊᩍဨࠊ⫋ဨࠊ࠾ࡼ㐠Ⴀ࡟㛵ࡍࡿࡈពぢ࣭ࡈ㉁ၥ➼ࡧ༠ຊဨࡀ┦ㄯ࡟ᛂࡌࡲࡍࠋ
ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊᩍဨࠊ⫋ဨࠊ࠶ࡿ࠸ࡣྛ㒊ᒁࡢ㐠Ⴀጤဨ࡟ࡈ㐃⤡ୗࡉ࠸ࠋ

Ѝ

7

2. ィ

ᶵჾࡢ฼⏝࡟㛵ࡍࡿ⏦ࡋྜࢃࡏࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ

㸦㊃᪨㸧
➨ 1 ᮲ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊࡢ⟶⌮ࡍࡿࠊู⾲ 1 ࡟ᐃࡵࡽࢀࡓィ ᶵჾ㸦㝃ᒓရࢆྵࡴࠋ௨ୗࠕィ ᶵჾࠖ࡜࠸࠺ࠋ㸧ࡢ฼⏝࡟ࡘ࠸࡚ࡣࠊࡇࡢ⏦ࡋྜࢃࡏࡢᐃࡵࡿ࡜ࡇࢁ࡟ࡼࡿࡶࡢ࡜ࡍࡿࠋ㸦⟶⌮㸧
➨ 2 ᮲ ィ ᶵჾ࡜ࡑࡢ ᐃᐊཬࡧ ᐃ‽ഛᐊࡢ⟶⌮ࡣࠊᐊ㛗ࡢ࿨࡟ࡼࡾࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ⫋ဨཬࡧィ ᶵჾẖ࡟ᐃࡵࡽࢀࡓ༠ຊဨࡀ⾜࠺ࠋ㸦฼⏝⪅ࡢ㈨᱁㸧➨ 3 ᮲ ィ ᶵჾࢆ฼⏝࡛ࡁࡿ⪅ࡣࠊู⾲ 1 ࡟ᥖࡆࡓ฼⏝⪅ࡢ㈨᱁࡟ヱᙜࡍࡿ⪅࡜ࡍࡿࠋࡓࡔࡋࠊࢥ࢔
ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊࡀ⾜࠺ㅮ⩦఍ࢆཷㅮࡋࡓ⪅࡟㝈ࡿࠋ㸦฼⏝ࡢ⏦ㄳ㸧➨ 4 ᮲ ィ ᶵჾࢆ฼⏝ࡋࡼ࠺࡜ࡍࡿ⪅ࡣᶵჾ฼⏝ㅮ⩦఍ཧຍ⏦ࡋ㎸ࡳཬࡧᶵჾ฼⏝⏦ㄳ᭩㸦ู⾲ 2㸧ࢆᐊ㛗࡟ᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦฼⏝ࡢᢎㄆ㸧➨ 5 ᮲ ᐊ㛗ࡣࠊ๓᮲ࡢ⏦ㄳࡀ㐺ᙜ࡛࠶ࡿ࡜ㄆࡵࡓ࡜ࡁ࡟ࡣࠊࡇࢀࢆᢎㄆࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸦ኚ᭦ࡢᒆฟ㸧➨ 6 ᮲ ๓᮲ࡢᢎㄆࢆᚓࡓ⪅ࡣࠊᶵჾ฼⏝ㅮ⩦఍ཧຍ⏦ࡋ㎸ࡳཬࡧᶵჾ฼⏝⏦ㄳ᭩ࡢグ㍕஦㡯࡟ኚ᭦ࡀ⏕ࡌࡓ࡜ࡁࡣࠊ㏿ࡸ࠿࡟ࡑࡢ᪨ࢆᐊ㛗࡟ᒆࡅฟ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦฼⏝ᡭ⥆㸧
➨ 7 ᮲ ฼⏝࡟ඛ❧ࡗ࡚ࠊ฼⏝⪅ࡣࠊ࠶ࡽ࠿ࡌࡵ฼⏝᪥᫬ࢆࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ⫋ဨ࡟┦ㄯࡢ࠺࠼ࠊ ᐃ⏦㎸⡙࡟グධࡋண⣙ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
2๓㡯ࡢண⣙ࢆኚ᭦ࠊⱝࡋࡃࡣ୰Ṇࡍࡿሙྜࡣ㐜⁫࡞ࡃࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ⫋ဨ࡟ᒆࡅฟ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

3฼⏝⪅ࡣࠊ ᐃ⤊஢ᚋࠊ┤ࡕ࡟ᡤᐃࡢグ㘓⡙࡟฼⏝ࡢ㡯┠ࢆグධࡋࠊᶵჾᐊෆࡢΎᤲࡋ࡞ࡅࢀࡤ࡞
ࡽ࡞࠸ࠋ㸦ὀព⩏ົ㸧
➨ 8 ᮲ ฼⏝⪅ࡣࠊィ ᶵჾࡢṇᖖ㐠⏝ࡀ⥔ᣢࡉࢀࡿࡼ࠺୓඲ࡢὀពࢆᡶ࠸ࠊ࠿ࡘ ᐃ࡟㛵ࡍࡿᡤᐃࡢ
᧯సἲࢆཝᏲࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ୓୍ࠊ␗ᖖࢆㄆࡵࡓ࡜ࡁࡣࠊ┤ࡕ࡟ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ⫋ဨཪࡣ༠ຊဨ࡟㐃⤡ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦⤒㈝ࡢ㈇ᢸ㸧➨9᮲ᐃ⤒㈝ࡣู⾲ 3 ࡟ᐃࡵࡿィ ᶵჾࡢ ᐃᩱ㔠࡟ࡼࡿࡶࡢ࡜ࡍࡿࠋ࡞࠾ண⣙᫬㛫ࢆࡶࡗ࡚౑⏝᫬㛫࡜ࡋࠊ㉸㐣ࡋࡓሙྜࡣ㉸㐣᫬㛫ࢆຍ⟬ࡍࡿࡶࡢ࡜ࡍࡿࠋ



2

฼⏝⪅ࡀࠊᨾពཪࡣ㐣ኻ࡟ࡼࡾࠊ⿦⨨ཬࡧ ᐃᐊ➼࡟㞀ᐖ࣭◚ᦆ➼ࢆᘬࡁ㉳ࡇࡋࡓሙྜࡣࠊ⌧≧࡟᚟ࡍࡿ㈝⏝ࢆ㈇ᢸࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

㸦฼⏝᫬㛫㸧
➨ 10 ᮲ ィᶵჾࡢ฼⏝᫬㛫ࡣཎ๎࡜ࡋ࡚ᶵჾศᯒࡢఇᴗ᪥௨እࡢู⾲ 1 ࡟ᐃࡵࡿ᫬㛫࡜ࡍࡿࠋࡓࡔࡋࠊᚲせ࡜ㄆࡵࡽࢀࡿሙྜࡣࡇࡢ㝈ࡾ࡛ࡣ࡞࠸ࠋ
2฼⏝⪅ࡀࠊ༗ᚋ 5 ᫬࠿ࡽ⩣ᮅ༗๓ 9 ᫬ࡲ࡛ࡢ㛫࡟฼⏝ࢆᕼᮃࡍࡿሙྜࡣࠊ฼⏝ᙜ᪥ࡢ༗ᚋ 4 ᫬ࡲ࡛࡟ᚲࡎࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ⫋ဨ࡟᫬㛫እ฼⏝ᒆ㸦ู⾲ 4㸧ࢆᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞
࠸ࠋ㸦฼⏝ࡢྲྀᾘ➼㸧➨ 11 ᮲

฼⏝⪅ࡀࠊࡇࡢ⏦ࡋྜࢃࡏ࡟㐪཯ࡋࠊཪࡣ ᐃᶵჾࡢṇᖖ㐠⏝ࡢ⥔ᣢ࡟㔜኱࡞ᨭ㞀ࢆ⏕ࡌࡉࡏࡓሙྜࠊཪࡣࡑࡢ࠾ࡑࢀࡢ࠶ࡿሙྜࡣࠊᐊ㛗ࡣ฼⏝ࡢᢎㄆࢆྲྀᾘࡋࠊཪࡣ୍ᐃᮇ㛫ࡢ฼⏝ࢆ೵Ṇࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
㸦㞧๎㸧
➨ 12 ᮲ ࡇࡢ⏦ࡋྜࢃࡏࡢᐇ᪋࡟㛵ࡋࠊᚲせ࡞஦㡯ࡣᐊ㛗ࡀᐃࡵࡿࠋ
㝃๎ࡇࡢ⏦ࡋྜࢃࡏࡣࠊ௧࿴ 4 ᖺ 5 ᭶ 1 ᪥࠿ࡽ᪋⾜ࡍࡿࠋ60ู⾲ 1 ฼⏝⪅㈨᱁
ィᶵჾྡ฼⏝⪅ࡢ㈨᱁㸦ὀ 1, 2, 3㸧㸦␎⛠㸧
㧗㍤ᗘ㹖⥺ᅇᢡ⿦
⨨ SmartLab 9kW(XRD)฼⏝᫬㛫㸦ὀ 4㸧⫋ဨ◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ㒊⏕௨ୖ฼⏝ࡍࡿ๓࡟ࠊᨺᑕ⥺సᴗᚑ஦⪅ࡢㅮ⩦఍ࢆཷㅮࡍࡿ

᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00

ࡇ࡜⫋ဨ㟁⏺ᨺᑕᆺ㏱㐣㟁
Ꮚ㢧ᚤ㙾
JEM2100FGK (TEM)◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕ (㈨᱁ࢆ᭷ࡍࡿᩍဨࡲࡓࡣ ኱Ꮫ㝔⏕(ᩍ⫱Ꮫ㒊࠾ࡼࡧᆅᇦ⛉Ꮫ㒊ࡢሙྜࠊᏛ㒊⏕) ࡢ❧ࡕ఍࠸ࡢࡶ࡜࡛ 3 ࣨ᭶௨ୖ౑⏝ࡋࡓ⪅)᭶᭙᪥㹼㔠᭙᪥
9:00 㹼17:00

฼⏝ࡍࡿ๓࡟ࠊᨺᑕ⥺సᴗᚑ஦⪅ࡢㅮ⩦఍ࢆཷㅮࡍࡿ
ࡇ࡜⏕యศᏊ㛫┦஫స⫋ဨ⏝ゎᯒࢩࢫࢸ࣒

◊✲ᐊ࡟ᡤᒓࡋ࡚࠸ࡿᏛ⏕ (㈨᱁ࢆ᭷ࡍࡿᩍဨࡲࡓ

᭶᭙᪥㹼㔠᭙᪥

Biacore T200ࡣ ኱Ꮫ㝔⏕(ᩍ⫱Ꮫ㒊࠾ࡼࡧᆅᇦ⛉Ꮫ㒊ࡢሙྜࠊᏛ㒊

9:00 㹼17:00(SPR)⏕) ࡢ❧ࡕ఍࠸ࡢࡶ࡜࡛ 3 ࣨ᭶௨ୖ౑⏝ࡋࡓ⪅)ὀ 1㸸฼⏝⪅ࡣࠊᐊ㛗ࡀ≉࡟㐺ᙜ࡜ㄆࡵࡓ⪅ࢆ฼⏝ྍ⬟࡜ࡍࡿࠋὀ 2㸸࠸ࡎࢀࡶ኱Ꮫ㝔ࡢᏛ⏕࡟ࡣࠊ6 ᖺㄢ⛬ࡢᏛ㒊࠾ࡼࡧᏛ⛉࡟ᡤᒓࡍࡿ 5ࠊ6 ᖺ⏕ࢆྵࡴࠋὀ 3㸸ᮏ኱Ꮫ࡜ࢭࣥࢱ࣮ࡢ฼⏝࡟㛵ࡋ࡚ྲྀࡾỴࡵࢆ⾜ࡗ࡚࠸ࡿ኱Ꮫ➼ࡢᶵ㛵ࡢᩍဨ࠾ࡼࡧᏛ⏕࡟ࡘ࠸࡚ࡶࠊ
ᮏᏛࡢ฼⏝㈨᱁࡟‽ࡎࡿࠋὀ 4㸸17:00 ௨㝆ࡢ฼⏝ᕼᮃ⪅ࡣࠕ᫬㛫እ฼⏝ᒆࠖࢆ 16:00 ㎾࡟ᥦฟୗࡉ࠸ࠋ

61

ู⾲ 2

௧࿴ 4 ᖺᗘ

㧗➼◊✲㝔 ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ᶵჾศᯒศ㔝ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊᶵჾ฼⏝⏦ㄳ᭩ཬࡧᶵჾ฼⏝ㅮ⩦఍ཧຍ⏦ࡋ㎸ࡳᒱ㜧኱Ꮫ 㧗➼◊✲㝔 ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ᶵჾศᯒศ㔝 ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ㛗Ẋୗグࡢ㏻ࡾᶵჾࢆ฼⏝ࡋࡓ࠸ࡢ࡛ࠊㅮ⩦఍࡟ཧຍࡋࡓᚋࠊᒱ㜧኱Ꮫ 㧗➼◊✲㝔 ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ᶵჾศᯒศ㔝ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊࠊ࠾ࡼࡧࠊᶵჾศᯒศ㔝฼⏝つ๎ࢆ㑂Ᏺࡋࠊ⏦ㄳࡋࡲࡍࠋ㸦Ặྡ㸧ᣦ ᑟ ᩍ ဨ㸦㐃⤡㈐௵⪅㸧

㸦⫋ྡ㸧

㸦ᡤᒓ㸧

Ꮫ㒊

Ꮫ⛉

ㅮᗙ࣭ࢥ࣮ࢫྡ

TEL㸸
㟁Ꮚ࣓࣮ࣝ࢔ࢻࣞࢫ㸸
㸦Ặྡ㸧
⤒

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㈐

㈇
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㸦⫋ྡ㸧

㸦ᡤᒓ㸧

Ꮫ㒊

Ꮫ⛉

ㅮᗙ࣭ࢥ࣮ࢫྡ

⪅
TEL㸸

฼

⏝
ᶵ

ᕼ
ჾ

ᮃ
ྡ

⏦ ㄳ ⪅

Ặ

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⫋ྡ (Ꮫᖺ)ෆ⥺㟁Ꮚ࣓࣮ࣝ࢔ࢻࣞࢫ

ㅮ⩦఍ཧຍᕼᮃ࠾ࡼࡧ
ཷㅮ῭⪅

ഛ⪃

ᶵჾศᯒศ㔝 ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ グධḍ
ཷ௜␒ྕ

ཷ௜᪥

࠾㢪࠸
࡞࠾ࠊᮏ◊✲࡟㛵ࡋ࡚ࡈⓎ⾲ࡢㄽᩥ࡟ࡣ౑⏝ࡋࡓᶵჾྡࢆ᫂グࡋ࡚࠸ࡓࡔࡁࠊㄽᩥูๅࡾ 1 㒊ࡲࡓࡣ㟁Ꮚࣇ࢓࢖ࣝࢆࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ࡟ࡈᥦฟࡃࡔࡉ࠸ࠋࡈ༠ຊࢆ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ

ᒱ㜧኱Ꮫ 㧗➼◊✲㝔 ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ᶵჾศᯒศ㔝 ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ㛗ὀព

1 ᶵჾࡢ౑⏝࡟ᙜࡓࡗ࡚ࡣ㸪ᶵჾࡈ࡜ࡢ౑⏝⏦㎸᭩ࢆู㏵ᥦฟࡋ࡚ࡃࡔࡉ࠸ࠋ
2 ࡇࡢ⏦ㄳ᭩࡟Ⓩ㘓㸦Ặྡ㸧ࡢ↓࠸᪉ࡣ฼⏝࡛ࡁࡲࡏࢇࠋࡲࡓ㸪ᶵჾ౑⏝ࡍࡿ࡟ࡣᩍဨࡀㅮ⩦఍῭ࡳࡲࡓࡣཧ
ຍᕼᮃࡍࡿࡇ࡜ࢆཎ๎࡜ࡋࡲࡍࠋㅮ⩦఍ࡢ᪥⛬ࡣ㐃⤡㈐௵⪅ᐄ࡟ e-mail ࡛㐃⤡ࡋࡲࡍࠋ
3 ࢭࣥࢱ࣮ࡢ฼⏝ᮇ㛫ࡣᙜヱᖺᗘෆ࡜ࡋ࡚ࡃࡔࡉ࠸ࠋ
4 ᪂つ฼⏝⪅ཪࡣࣃࢫ࣮࣡ࢻኚ᭦ᕼᮃ⪅ࡣୗࡢḍࢆグධࡋ࡚ࡃࡔࡉ࠸ࠋ
㸦⿦⨨ࡢண⣙࡟ࣟࢢ࢖ࣥ ID ࡜ࣃࢫ࣮࣡ࢻࡀᚲせ࡛ࡍࠋⱥᩘᏐ 6 ᩥᏐ௨ୖ࡛タᐃࡋ࡚ࡃࡔࡉ࠸ࠋ
㸧ࣟࢢ࢖ࣥ ID

ࣃࢫ࣮࣡ࢻ

62

ู⣬
⏦ ㄳ ⪅

Ặ

ྡ

⫋ྡ (Ꮫᖺ)ෆ⥺

63㟁Ꮚ࣓࣮ࣝ࢔ࢻࣞࢫ

ㅮ⩦఍ཧຍᕼᮃ࠾ࡼࡧ
ཷㅮ῭⪅

ഛ⪃

ู⾲ 4.
ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝 ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ᫬㛫እ฼⏝ᒆ
ᣦᑟᩍဨྡ
ᅾ

Ꮫ㒊
Ꮫ⛉

ᐊ
⪅

ㅮᗙ
ෆ⥺

㌟ศ㸦Ꮫᖺ㸧

Ặྡ

౑⏝ࡍࡿᶵ

1.

㧗㍤ᗘ㹖⥺ᅇᢡ⿦⨨ (XRD) SmartLab 9kW

ჾࡢ␒ྕ࡟

2.

㟁⏺ᨺᑕᆺ㏱㐣㟁Ꮚ㢧ᚤ㙾 (TEM) JEM-2100FGK

3.

⏕యศᏊ㛫┦஫స⏝ゎᯒࢩࢫࢸ࣒ (SPR) Biacore T200

ࠐࢆࡘࡅ࡚
ࡃࡔࡉ࠸ࠋ

฼⏝᪥᫬

᭶

᪥㸦

㸧

᫬

ศ

᭶

᪥㸦

㸧

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ศ

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3. ཷクヨ㦂࡟ࡘ࠸࡚㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝 ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊཷクヨ㦂㸪 ᐃཬࡧ᳨ᰝ➼ྲྀᢅせ㡯
䠄㊃᪨䠅➨䠍᮲ ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊䠄௨ୗ䛂䝉䞁䝍䞊䡟䛸䛔䛖䚹䠅䛻䛚䛔䛶䠈ᮾᾏᅜ❧኱Ꮫᶵᵓཷク◊✲つ⛬➨䠎䠐᮲➨䠐㡯䛻ᇶ䛵䛝⾜䛖ᐃᆺⓗ䛺ヨ㦂䠈 ᐃཬ䜃᳨ᰝ➼䛾ཷク◊✲䠄௨ୗ䛂ヨ㦂➼䛃䛸䛔䛖䚹䠅䛾ྲྀᢅ䛔䛻䛴䛔䛶䛿䠈䛣䛾せ㡯䛾ᐃ䜑䜛䛸䛣䜝䛻䜘䜛䚹䠄⏦㎸䜏䛾᪉ἲ䠅➨䠎᮲ ヨ㦂➼䛾⏦㎸䜏䛿䠈ู⣬ᵝᘧ➨䠍ྕ䛻䜘䜚⾜䛖䜒䛾䛸䛩䜛䚹䠄ཷධ᮲௳䠅
➨䠏᮲ ヨ㦂➼䛾ཷධ䜜䛾᮲௳䛿䠈ḟ䛾ྛྕ䛻ᥖ䛢䜛䜒䛾䛸䛩䜛䚹୍ ➨䠒᮲䛻ᐃ䜑䜛ヨ㦂➼䛾ᩱ㔠䛿ཎ๎䛸䛧䛶๓⣡䛩䜛䜒䛾䛸䛩䜛䚹䛯䛰䛧㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙䝉䞁䝍䞊㛗䠄௨ୗ䛂䝉䞁䝍䞊㛗䛃䛸䛔䛖䚹䠅䛜≉ู䛾஦⏤䛜䛒䜛䛸ㄆ䜑䛯ሙྜ䛻䛿ᚋ⣡䛸䛩䜛䛣䛸䛜䛷䛝䜛䚹஧ ጤク⪅䛛䜙䛾⏦䛧ฟ䛻䜘䜚ヨ㦂➼䜢୰Ṇ䛧䛯ሙྜ䛻䛚䛔䛶䜒ᩱ㔠䛿㏉㑏䛧䛺䛔䚹䛯䛰䛧䠈≉ู䛾஦᝟䛜䛒䜛ሙྜ䛻䛿䠈䛭䛾඲㒊䜎䛯䛿୍㒊䜢㏉㑏䛩䜛䛣䛸䛜䛒䜛䚹ḟ䛻ᥖ䛢䜛ሙྜ䛻䛿䠈ጤク⪅䛾ཷ䛡䜛ᦆᐖ䛻ᑐ䛧䛶䝉䞁䝍䞊䛿䛭䛾㈐௵䜢㈇䜟䛺䛔䚹䜲 䜔䜐䜢ᚓ䛺䛔஦⏤䛻䜘䛳䛶ヨ㦂➼䜢୰Ṇ䛧䛯䛯䜑ᦆᐖ䛜⏕䛨䛯䛸䛝䚹䝻 ヨ㦂➼䜢⾜䛖䛯䜑䛻ᥦฟ䛥䜜䛯ᮦᩱ➼䠄௨ୗ䛂ᮦᩱ➼䛃䛸䛔䛖䚹䠅䛻ᦆᐖ䛜⏕䛨䛯䛸䛝䚹䝝 ➨භྕ䛾ሙྜ䛻䛚䛔䛶䠈䝉䞁䝍䞊䛾ᶵჾ➼䜢౑⏝䛩䜛⪅䛾㈐䛻䜘䜛஦⏤䛻䜘䛳䛶ᦆᐖ䛜⏕䛨䛯䛸䛝䚹୕ ヨ㦂➼䛾ᐇ᪋ୖ䝉䞁䝍䞊㛗䛜ᚲせ䛸ㄆ䜑䛯䛸䛝䛿䠈ᮦᩱ➼䛾෌ᥦฟ䜢ồ䜑䜛䛣䛸䛜䛷䛝䜛䚹ᅄ ᮦᩱ➼䛾ᦙධཬ䜃ᦙฟ䛿䠈䛩䜉䛶ጤク⪅䛜⾜䛖䜒䛾䛸䛩䜛䚹஬ 䝉䞁䝍䞊㛗䛜ཷධ䜜䛷䛝䛺䛔䛸ุ᩿䛧䛯ᮦᩱ➼䛻ಀ䜛ヨ㦂➼䛻䛴䛔䛶䛿䠈ཷධ䜜䜢䛧䛺䛔䛣䛸䛜䛷䛝䜛䚹භ ጤク⪅䛜Ꮫෆᢸᙜ⪅䛾ᣦᑟ䞉❧఍䛾ୗ䛷┤᥋䝉䞁䝍䞊䛾ᶵჾ➼䜢౑⏝䛩䜛ሙྜ䛿䠈ู⣬ᵝᘧ➨䠎ྕ䛾౑⏝⏦ㄳ᭩䜢ᥦฟ䛧䠈ྠ᭩䛾☜ㄆ஦㡯䜢㑂Ᏺ䛧ヨ㦂➼䜢⾜䛖䛣䛸䛸䛩䜛䚹䛯䛰䛧䚸౑⏝⪅䛿䚸䝉䞁䝍䞊䛜⾜䛖ᶵჾศᯒ䛾౑⏝䛻㛵䛩䜛ㅮ⩦఍䜢ཷㅮ䛧䛯⪅䛻㝈䜛䚹䠄ཷධ䜜ཬ䜃⤖ᯝ䛾㏻▱)➨䠐᮲ ヨ㦂➼䛾ཷධ䜜ཬ䜃䛭䛾⤖ᯝ䛾㏻▱䛿䠈䝉䞁䝍䞊㛗䛾ᐃ䜑䜛ᡭ⥆䜢⤒䛶⾜䛖䜒䛾䛸䛩䜛䚹䠄⛎ᐦ䛾ಖᣢ➼䠅➨䠑᮲ 䝉䞁䝍䞊ཬ䜃ጤク⪅䛿䚸ヨ㦂➼䛾ᐇ᪋䛷▱䜚ᚓ䛯┦ᡭ᪉䛾⛎ᐦ䠈▱ⓗ㈈⏘➼䜢┦ᡭ᪉䛾᭩㠃䛻䜘䜛ྠព䛺䛧䛻බ㛤䛧䛶䛿䛺䜙䛺䛔䚹䠎ᐃ䛷ᚓ䜙䜜䛯䝕䞊䝍䜢ጤク⪅䛜බ⾲䛩䜛ሙྜ䠈ཎ๎䛸䛧䛶ᒱ㜧኱Ꮫྡ䜢౑⏝䛩䜛䛣䛸䛿䛷䛝䛺䛔䚹䜎䛯䚸ᒱ㜧኱Ꮫ䜢≉ᐃ䛷䛝䜛⾲⌧䜒ྠᵝ䛸䛩䜛䚹䛯䛰䛧䚸䝉䞁䝍䞊㛗䛜኱Ꮫྡ䛾౑⏝䜢チྍ䛧䛯ሙྜ䛻䛿䛣䛾㝈䜚䛷䛿䛺䛔䚹䠄ヨ㦂➼䛾ᩱ㔠䠅➨䠒᮲ ヨ㦂➼䛾ᩱ㔠䛿䠈ู⾲䛾䛸䛚䜚䛸䛩䜛䚹䛯䛰䛧䠈◊✲ᩍ⫱ୖ䝉䞁䝍䞊㛗䛜ᚲせ䛸ㄆ䜑䛯ヨ㦂➼䛾䛯䜑䛾ᮦᩱ➼䛾ᥦ౪䜢せㄳ䛧䛯ሙྜ䛻䛿ᩱ㔠䜢཰⣡䛧䛺䛔䛣䛸䛜䛷䛝䜛䚹䠎 ヨ㦂➼䛾ᩱ㔠䛿䠈ᮾᾏᅜ❧኱Ꮫᶵᵓ䛜Ⓨ⾜䛩䜛ㄳồ᭩䛻䜘䜚཰⣡䛩䜛䚹㝃 ๎䛣䛾せ㡯䛿䠈௧࿴ 4 ᖺ 5 ᭶䠍᪥䛛䜙ᐇ᪋䛩䜛䚹

5

ู⾲

ヨ㦂➼ࡢᇶᮏ฼⏝ᩱ㔠㸦ὀ 1, 2㸧
ᶵ

ჾ

ྡ

ᩘ

㔞

ᩱ

㔠 㸦෇㸧

ᇶᮏ ᐃ 1 ᳨యࡑࡢ௚≉Ṧ ᐃ31,000ᛂ┦ㄯ㟁⏺ᨺᑕᆺ㏱㐣㟁Ꮚ㢧ᚤ㙾 (TEM) JEM-2100FGK

1 ᳨య

42,000⏕యศᏊ㛫┦஫స⏝ゎᯒࢩࢫࢸ࣒ (SPR) Biacore T200

1 ᳨య

42,000㧗㍤ᗘ㹖⥺ᅇᢡ⿦⨨ (XRD) SmartLab 9kW

(ὀ 1)
(ὀ 2)

ᾘ㈝⛯ࡣᩱ㔠࡟ࡣྵࡲࢀ࡚࠾ࡽࡎ㸪ู㏵ㄳồࡍࡿࠋ๓ฎ⌮࣭ᾘ⪖ရ➼ࡀᚲせ࡞ሙྜ࡟ࡘ࠸࡚ࡣ㸪ู㏵┦ㄯࡢୖ㸪☜ᐃࡍࡿࠋཷクヨ㦂➼䛾ᡭ⥆䛝(1) ཷクヨ㦂➼ࡢࡈ┦ㄯཷクヨ㦂ࡸศᯒࡢࡈ┦ㄯࡀ࠶ࡾࡲࡋࡓࡽࠊ㟁ヰ➼࡟࡚ࡈ㐃⤡ࡃࡔࡉ࠸ࠋࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ
⏝㐃ᦠᐊࡢ⫋ဨࡀ㐺ษ࡞ᶵჾᢸᙜ⪅ࢆࡈ⤂௓࠸ࡓࡋࡲࡍࠋ
(2) ᡴྜࡏ᪥ࡢỴᐃᢸᙜ⫋ဨ࡜ヨ㦂࡟ࡘ࠸࡚ᡴྜࡏࢆ⾜࠺᪥⛬ࢆㄪᩚࡋ࡚ࡃࡔࡉ࠸ࠋ
(3) ヨ㦂ᡴྜࡏࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ࡟࠾㉺ࡋ࠸ࡓࡔࡁࠊࡲࡓࡣࠊ࢜ࣥࣛ࢖࡛ࣥࠊᢸᙜࡢ⫋ဨ࡜ヨ㦂ෆᐜࠊᐇ᪋᪥➼ࡢᡴྜࡏࢆ⾜࡞࠸ࡲࡍࠋࡑࡢ᫬࡟ヨ㦂ࢧࣥࣉࣝࡸヨ㦂࡟㛵ࡍࡿ㈨ᩱࡀࡈࡊ࠸ࡲࡋ
ࡓࡽࠊ୍⥴࡟࠾ᣢࡕࡃࡔࡉ࠸ࠋ ࡞࠾ࠊヨ㦂ࡢෆᐜࡸヨ㦂ࢧࣥࣉࣝࡢᙧ≧࡟ࡼࡗ࡚ࡣࠊヨ㦂ࡀ⾜࡞࠼࡞࠸ሙྜࡶ࠶ࡾࡲࡍࠋ
(4) ཷクヨ㦂ࡢ࠾⏦ࡋ㎸ࡳཷクヨ㦂ࢆ⏦ࡋ㎸ࡲࢀࡿ᫬ࡣࠊ౫㢗᭩࡟ࡈグධ࠸ࡓࡔࡁࠊ฼⏝ᩱ㔠ࢆ࠾ᨭᡶ࠸ࡓࡔࡁࡲࡍࠋ
(5) ヨ㦂➼ࡢᐇ᪋
ヨ㦂➼ᐇ᪋᪥࡟ࡣ㸪ヨ㦂ࢧࣥࣉࣝࢆ࠾ᣢࡕ㎸ࡳ࠸ࡓࡔࡁ ᐃ࡟ྠᖍࡋ࡚ࡃࡔࡉ࠸ࠋ
(6) ࢹ࣮ࢱࡢཷ㡿ྠᖍࡋ࡚࠸ࡓࡔࡁ࡞ࡀࡽᚓࡽࢀࡓࢹ࣮ࢱࢆᇶ࡟ᢸᙜࡢᩍ⫋ဨ࡜ෆᐜ࡟ࡘ࠸࡚༠㆟ࡋࠊࢹ࣮ࢱࢆ࠾
ᣢࡕᖐࡾୗࡉ࠸ࠋ

6ู⣬ᵝᘧ➨㸯ྕࢭࣥࢱ࣮㛗ᶵჾศᯒศ㔝ࢥ࢔ࣇ࢓ࢩࣜࢸ
࢕ᶵჾඹ⏝㐃ᦠᐊศ㔝㛗◊✲┤㎄ᣐⅬㄢ㛗⿵బᣐⅬᨭ᥼ࢢ࣮ࣝࣉ

ͤ஦ົᢸᙜ⪅☜ㄆ⏝ཷ௜␒ྕྕᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ᶵჾศᯒศ㔝ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ ཷクヨ㦂➼౫㢗᭩௧࿴ᖺ᭶ᅜ❧኱Ꮫἲேᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗 Ẋ᪥ఫᡤཪࡣᡤᅾᆅ
௻ᴗ➼ྡཬࡧ௦⾲⪅ྡ㸦㐃⤡ඛ㸧ᢸᙜ⪅㸦ᡤᒓ࣭Ặྡ㸧㟁ヰ␒ྕ
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᪥

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ᖺ

᭶
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7ᐃࡣ⾜ࢃࢀࡲࡏࢇࠋ

᪥ู⣬ᵝᘧ➨ 2 ྕ
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◊✲┤㎄ᣐⅬㄢ㛗⿵బᣐⅬᨭ᥼ࢢ࣮ࣝࣉ

ͤ஦ົᢸᙜ⪅☜ㄆ⏝ᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ศᯒᶵჾ➼౑⏝⏦ㄳ᭩
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ᅜ❧኱Ꮫἲேᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮㛗Ẋᡤᒓᶵ㛵㸦఍♫㸧ఫᡤᡤᒓᶵ㛵㸦఍♫㸧ྡ
౑⏝⪅Ặྡ
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ୗグࡢ☜ㄆ᮲㡯࡟ྠពࡋ㸪ศᯒᶵჾ➼ࡢ౑⏝࡟ࡘ࠸࡚⏦ㄳࡋࡲࡍࠋ㸯 ศᯒᶵჾ౑⏝࣭ ᐃ࡟ࡘ࠸࡚ࡣࠊ⏦㎸᫬࡟౑⏝⪅ࡀᒱ㜧኱Ꮫࡢᢸᙜ⪅࡜༑ศ࡞┦ㄯࢆࡋ࡚ࠊࠕᮾᾏᅜ
❧኱Ꮫᶵᵓᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ཷクヨ㦂➼౫㢗᭩ࠖࢆᥦฟࡍࡿࠋ㸰 ౑⏝࣭ ᐃࡢᩱ㔠ࡣ౑⏝๓࡟⣡ධࡍࡿࡶࡢ࡜ࡍࡿࠋ౑⏝࣭ ᐃࢆ୰Ṇࡋࡓሙྜ࡟࠾࠸࡚ࡶᩱ㔠ࡣ౑⏝⪅࡟㏉㑏ࡋ࡞࠸ࠋ㸱 ศᯒ⿦⨨ࡢᨾ㞀࡞࡝࡛ ᐃ࡛ࡁ࡞ࡃ࡞ࡗࡓሙྜ࡟ࡣࠊ ᐃࢆᘏᮇࡍࡿࡇ࡜ࡀ࠶ࡿࡀࠊࡑࢀ࡟㛵ࢃࡿᦆᐖࢆ౑⏝⪅ࡣㄳồ࡛ࡁ࡞࠸ࠋ㸲 ࢭࣥࢱ࣮㛗ཬࡧᢸᙜ⪅ࡣࠊ౑⏝⪅ࡀᶵჾࢆྲྀࡾᢅ࠺ࡢ࡟༑ศ࡞㈨㉁ࢆ᭷ࡋ࡚࠸࡞࠸࡜ุ᩿ࡋࡓ࡜ࡁ
࡟ࡣࠊ࠸࠿࡞ࡿ᫬Ⅼ࡟࠾࠸࡚ࡶసᴗࢆไṆ࡛ࡁࡿࠋࡲࡓࠊẘ≀ࡸἲᚊ➼࡟ゐࢀࡿࡶࡢࠊࡉࡽ࡟ࠊᶵ
ჾࢆ◚ᦆࡍࡿᜍࢀࡢ࠶ࡿࡶࡢ࡞࡝ࢭࣥࢱ࣮㛗ཬࡧᢸᙜ⪅ࡀཷධࢀ࡛ࡁ࡞࠸࡜ุ᩿ࡋࡓࡶࡢ࡟ࡘ࠸࡚ࡣࠊ ᐃࢆᣄྰࡍࡿࠋ㸳 ౑⏝࣭ ᐃ࡟ࡘ࠸࡚ࡣࠊ౑⏝⪅ࡣ༢⊂࡛ࡍࡿࡢ࡛ࡣ࡞ࡃࠊᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࡢᢸᙜ⪅ࡀྠᖍࡋ࡚ࠊᢸᙜ⪅ࡢᣦᑟ࣭❧఍࠸ࡢୗ࡛౑⏝⪅ࡀసᴗࡍࡿࠋ౑⏝⪅ࡢ㈐௵࡛ᶵჾࢆᲠᦆࡲࡓࡣ⁛ኻࡋࡓ࡜ࡁ࡟ࡣࠊ౑⏝⪅ࡀࡇࢀࢆཎᙧ࡟᚟ࡋࠊࡲࡓᦆᐖࢆ㈺ൾࡍࡿࠋ㸴 ౑⏝⪅ࡣࠊᶵჾࡢ฼⏝࡟ᙜࡓࡗ࡚ࠊ㛵ಀἲᚊࢆᏲࡾࠊᏳ඲⾨⏕ᑐ⟇ࠊ஦ᨾ㜵Ṇ࡟༑ศὀពࢆᡶ࠺ࡶ
ࡢ࡜ࡍࡿࠋࡲࡓࠊ౑⏝⪅ࡣࠊᣦᐃࡉࢀࡓሙᡤ௨እ࡟チྍ࡞ࡃฟධࡾࡍࡿࡇ࡜ࡣ࡛ࡁ࡞࠸ࠋ㸵 ๓グ 6 ࡢ㡯┠࡟཯ࡋ࡚ࠊ౑⏝⪅ࡢ㐣ኻ࡟ࡼࡾᮏேࡀ᛹ᡃࡲࡓࡣ⑓Ẽࢆࡋࡓሙྜࡣࠊᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࡣ୍ษ㈐௵ࢆ㈇ࢃ࡞࠸ࡶࡢ࡜ࡍࡿࠋ㸶 ౑⏝⪅ࡣࠊᢎㄆࡉࢀࡓ᫬㛫ෆ࡟Ύᤲࢆྵࡵ࡚ࡍ࡭࡚ࡢసᴗࢆ⤊஢ࡍࡿࠋ㸷ᐃ࡛ᚓࡽࢀࡓࢹ࣮ࢱࡣࠊᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࡀಖ㞀ࡍࡿࡶࡢ࡛ࡣ࡞࠸ࠋࡑࡢࡓࡵࠊࢹ࣮ࢱ
ࡢእ㒊࡬ࡢබ⾲࡟࠾࠸࡚ࠊ࠸࠿࡞ࡿሙྜ࡟࠾࠸࡚ࡶᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫྡࢆ౑࠺ࡇ࡜ࡣ࡛ࡁ
࡞࠸ࠋࡲࡓࠊࡑࡢ㝿࡟ᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࢆ≉ᐃ࡛ࡁࡿ⾲⌧ࡶ౑࠼࡞࠸ࠋࡓࡔࡋࠊࢭࣥࢱ࣮
㛗ࡀ኱Ꮫྡࡢ౑⏝ࢆチྍࡋࡓሙྜ࡟ࡣࡇࡢ㝈ࡾ࡛ࡣ࡞࠸ࠋ
10 ๓グ 9 ࡢ㡯┠࡟཯ࡋ࡚ࠊእ㒊࡟බ⾲ࡋࡓࡇ࡜࡛ᮾᾏᅜ❧኱Ꮫᶵᵓᒱ㜧኱Ꮫࡀཷࡅࡓ⿕ᐖཬࡧᦆᐖ࡟
ࡘ࠸࡚ࡣࠊ౑⏝⪅ཬࡧࡑࡢ఍♫ࡀ㈺ൾࡍࡿࡶࡢ࡜ࡍࡿࠋ

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άືሗ࿌

1. ฼⏝⪅◊✲ㄽᩥ୍ぴ䕿 ཎⴭㄽᩥ䠖
1. R. Kumar, Y. Hazama, F. Ohashi, H. S. Jha, T. Kume, A fabrication method for type-II Ge clathrate
film by annealing of Ge film covered with Na layer, Thin Solid Films, 734, 138859/1-4 (2021)䠖
(;5')
2. S. L. Higashi, Masato Ikeda, Development of an amino sugar-based supramolecular hydrogelator
with reduction responsiveness, JACS Au, 1 (10), pp.1639-1646 (2021): 䠄7(0䠅
3. Rahman MM, Takashima S, Kamatari YO, Badr Y, Shimizu K, Okada A, Inoshima Y, Putativeinternal control genes in bovine milk small extracellular vesicles suitable for normalization inquantitative real time-polymerase chain reaction, Membranes 11, 933 (2021) 䠖 (7(0)
4. Rahman MM, Takashima S, Kamatari YO, Shimizu K, Okada A, Inoshima, Y, Comprehensive
proteomic analysis revealed a large number of newly identified proteins in the small extracellular
vesicles of milk from late-stage lactating cows, Animals, 11: 2506, (2021) 䠖 (7(0)
5. Rahman MM, Takashima S, Kamatari YO, BadrY, Kitamura Y, Shimizu K, Okada A, Inoshima Y,
3URWHRPLFSURILOLQJRIPLONVPDOOH[WUDFHOOXODUYHVLFOHVIURPERYLQHOHXNHPLDYLUXVဩLQIHFWHGFDWWOH
Sci. Rep, 11, 2951, (2021) 䠖 (7(0)
6. Inden M, Takagi A, Kitai H, Ito T, Kurita H, Honda R, Kamatari YO, Nozaki S, Wen X, Hijioka M,
Kitamura Y, Hozumi I. Kaempferol has potent protective and antifibrillogenic effects for Į-synuclein
neurotoxicity in vitro. Int J Mol Sci. 22, 11484 (2021) 䠖 (7(0)

2. ࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊᩍဨࡢᩍ⫱࣭◊✲άື➼1) ᩍ⫱άື
1. ࠕ㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉๰⸆ேᮦ⫱ᡂᩍ⫱ࣉࣟࢢ࣒ࣛࠖ2 ༢఩㸦15 ᅇࡢ࠺ࡕ 1 ᅇࢆᢸᙜ㸧2) ◊✲άື
ࠑཎⴭㄽᩥ࣭ⴭ᭩➼ࠒ
1. Rahman MM, Takashima S, Kamatari YO, Badr Y, Shimizu K, Okada A, Inoshima Y. Putative Internal
Control Genes in Bovine Milk Small Extracellular Vesicles Suitable for Normalization in Quantitative
Real Time-Polymerase Chain Reaction. Membranes (Basel). 11, 933 (2021).
2. Inden M, Takagi A, Kitai H, Ito T, Kurita H, Honda R, Kamatari YO, Nozaki S, Wen X, Hijioka M,
Kitamura Y, Hozumi I. Kaempferol Has Potent Protective and Antifibrillogenic Effects for ĮSynuclein Neurotoxicity In Vitro. Int J Mol Sci. 22, 11484 (2021).
3. Hirata Y, Motoyama M, Kimura S, Takashima M, Ikawa T, Oh-Hashi K, Kamatari YO. Artepillin C,
a major component of Brazilian green propolis, inhibits endoplasmic reticulum stress and protein
aggregation. Eur J Pharmacol. 912, 174572 (2021).
4. Rahman MM, Takashima S, Kamatari YO, Shimizu K, Okada A, Inoshima Y. Comprehensive
Proteomic Analysis Revealed a Large Number of Newly Identified Proteins in the Small Extracellular
Vesicles of Milk from Late-Stage Lactating Cows. Animals (Basel). 11, 2506 (2021).
5. Hayashi T, Kawasaki M, Kamatari YO, Oda M. Protein structure and analysis single-chain Fv
antibody covalently linked to antigen peptides and its structural evaluation. Anal Biochem. 629,
114312, (2021).
6. Tanaka N, Kimura S, Kamatari YO, Nakata K, Kobatake Y, Inden M, Yamato O, Urushitani M, Maeda
S, Kamishina H. In vitro evidence of propagation of superoxide dismutase-1 protein aggregation incanine degenerative myelopathy. Vet J. 274, 105710, (2021).
7. Tange H, Ishibashi D, Nakagaki T, Taguchi Y, Kamatari YO, Ozawa H, Nishida N. Liquid-liquid
phase separation of full-length prion protein initiates conformational conversion in vitro. J Biol Chem.
296, 100367, (2021).
8. Rahman MM, Takashima S, Kamatari YO, Badr Y, Kitamura Y, Shimizu K, Okada A, Inoshima Y.
Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected cattle.

70

Sci Rep. 11, 2951, (2021).
ࠑᏛ఍Ⓨ⾲ࠒ
㸦ᅜ㝿Ꮫ఍㸧
1. Y. O. Kamatari, S. Yamashita, R. Honda, & K. Kuwata, Monomeric D-synuclein (DS) inhibits
amyloidogenesis of human prion protein (hPrP) by forming a stable DS-hPrP hetero-dimer, 22ndInternational Society of Magnetic Resonance Conference (ISMAR), 2021/8/24, Online.
3) ⿵ຓ㔠㛵㐃᥇ᢥ≧ἣ
1. 2020㹼2022 ᖺᗘ ⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲(B) (୍⯡) (ศᢸ)ࠕࣇ࢓࣮࣐ࢥࣇ࢛࢔ࣔࢹࣝࢆ
Ỵᐃࡍࡿィ⟬⛉Ꮫᢏ⾡ࡢ☜❧࡜ᢠࣉࣜ࢜ࣥ໬ྜ≀ࡢ㛤Ⓨࠖ㸦㙊㊊㸧
2. 2020㹼2022 ᖺᗘ ⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲(C) (୍⯡) (ศᢸ)ࠕ᪕ẟ⹸ศἪࢱࣥࣃࢡ㉁࡟ࡼ
ࡿᐟ୺➽⫗⣽⬊ኚ␗ࡢศᏊ⏕≀Ꮫⓗ࠾ࡼࡧᵓ㐀⏕≀Ꮫⓗゎᯒࠖ㸦㙊㊊㸧
3. 2020㹼2021 ᖺᗘ ⛉Ꮫ◊✲㈝⿵ຓ㔠 ᇶ┙◊✲(C) (୍⯡) (ศᢸ)ࠕ≟ࡢኚᛶᛶ⬨㧊⑕ࢆ㉳ࡇࡍ
ኚ␗ SOD1 ⺮ⓑ㉁ࡢ❧యᵓ㐀ゎᯒ࡜἞⒪ᇶ┙ࡢᵓ⠏ࠖ㸦㙊㊊㸧㸦ᙺဨ➼㸧
1. ᪥ᮏ⏕≀≀⌮Ꮫ఍ศ㔝ูᑓ㛛ጤဨ㸦㙊㊊㸧
2. ᒱ㜧ᵓ㐀⏕≀Ꮫ࣭་Ꮫ࣭ㄽ⌮ⓗ๰⸆◊✲఍஦ົᒁ㸦㙊㊊㸧
3. Molecules Editorial Board㸦㙊㊊㸧71‫ ە‬
ᖹᡂ 16 ᖺ࡟ᖺሗ➨ 1 ྕࡀⓎหࡉࢀ࡚௨㝆ࠊ௒ᅇ࡛➨ 19 ྕࢆ㏄࠼ࡿࡇ࡜࡜࡞ࡾࡲࡋࡓࠋ
ࡇࡢ㛫ࠊඹྠ฼⏝᪋タ࡜ࡋ࡚タ❧ࡉࢀࡓ⏕࿨⛉Ꮫ⥲ྜᐇ㦂ᨭ᥼ࢭࣥࢱ࣮ࡣࠊ⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮ࠊ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮࡬࡜ᨵ⛠࣭ᨵ⤌ࢆ⤒࡚ࠊᏛෆእࡢᩘከࡃࡢ᪉ࠎ
࡟ࡈ฼⏝࠸ࡓࡔ࠸ࡓ⤖ᯝࠊ╔ᐇ࡟ᡂᯝࢆୖࡆࡿࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋ
ᮏྕ࠿ࡽࠊࡇࢀࡲ࡛ࡢ 5 ศ㔝 1 㒊㛛㸦ࢤࣀ࣒◊✲ศ㔝ࠊ᎘Ẽᛶ⳦◊✲ศ㔝ࠊື≀ᐇ㦂ศ㔝ࠊᶵჾศᯒศ㔝ࠊᨺᑕᛶྠ఩ඖ⣲ᐇ㦂ศ㔝ࠊᢠ㓟໬◊✲㒊㛛㸧࡟ຍ࠼ࠊ᪂ࡓ࡟ 3 ᐊ㸦㧗➼◊✲㝔㑇ఏᏊ᳨ᰝᐊࠊ◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊࠊࢥ࢔ࣇ࢓ࢩࣜࢸ࢕ᶵჾඹ⏝㐃ᦠᐊ㸧ࡢάືሗ࿌ࢆຍ࠼ࡲࡋࡓࠋࡇࢀ࡟ࡼࡾࠊᮏࢭࣥࢱ࣮ࡀ㏆ᖺ࡟Ꮫෆእࡢ฼⏝࡜ཷクゎᯒࡢᣑ඘ࢆᅗࡾࠊ᭦࡞ࡿᏛෆ࣭ᆅᇦ㈉⊩ࢆ┠ᣦࡋ࡚࠸ࡿࡇ࡜ࢆ▱ࡿ୍ᶵ఍࡜࡞ࢀࡤᖾ࠸࡛ࡍࠋ
᭱ᚋ࡟࡞ࡾࡲࡋࡓࡀࠊᮏྕⓎห࡟࠶ࡓࡾࠊཎ✏సᡂ࡟ࡈ༠ຊ࠸ࡓࡔࡁࡲࡋࡓᩍ⫋ဨࡢ᪉ࠎࠊ
ᮏࢭࣥࢱ࣮ࡢ฼⏝ᐇ⦼➼ࡢ᝟ሗࢆᥦ౪࠸ࡓࡔࡁࡲࡋࡓ฼⏝⪅ࡢⓙᵝ࡟ࠊឤㅰࡢពࢆ⾲ࡋࠊ⦅㞟ᚋグ࡜ࡉࡏ࡚࠸ࡓࡔࡁࡲࡍࠋ
௧࿴ 4 ᖺ 8 ᭶⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮᎘Ẽᛶ⳦◊✲ศ㔝ᚋ⸨ 㝯ḟ72