ࠬ‫ס‬൫ଢ଼ۛ৪ͅచ̳ͥ΃σΣΙϋ༞ਰၷ༹͈ႉ઄ບ‫ث‬઀ႅု໹Ȃෝഴࢤ࢕Ȃऑُ͘͠ঊȂऎș࿐ဇ๼Ȃऎ൥߼ঊȂऎș࿐‫ج‬ජȂ߄࿤ဉٚȂ२‫ཻ׆‬ဇ๼Ȃऎ൥‫׫‬Ȃ൬࿥୆Ȃऎș࿐၉Ȃऎ൥ఱ༟ȂෝഴदȂෝഴໍ֓ၷ༹૽ਝന๥ෂ‫·شܕ‬ςΣΛ·ńŭŪůŪŤŢŭ ŦŷŢŭŶŢŵŪŰů Űŧ ŵũŦ ŤŢųůŪŵŪůŦ ųŦűŭŢŤŦŮŦůŵŵũŦųŢűź ŧŰų ŵũŦ ũŦŮŰťŪŢŭźŴŪŴ űŢŵŪŦůŵŚŰũŦŪ ŌŰţŢźŢŴũŪĭ ŉŪųŰŮŪŵŴŶ ŏŰŵŰȄŎŢźŶŬŰ ŔŢŨŢĭ ŚŶŮŪ ŔŢŴŢŬŪĭ ŌŦŪŬŰ ŔŢŵŰĭŌŢůŢ ŔŢŴŢŬŪĭ ŚŶŴŶŬŦ ŌŰůůŰĭ ŎŢźŶŮŪ ŎŪŶųŢĭ ŎŢťŰŬŢ ŔŢŵŰĭ ŚŢźŰŪ łţŶŮŪĭłŪ ŔŢŴŢŬŪĭ ŅŢŪŴŶŬŦ ŔŢŵŰĭ łźŢ ŏŰŵŰĭ ŎŢŪ ŏŰŵŰłŬŪŵŢ ŖųŰŭŰŨŪŤ ńŭŪůŪŤɃ੣࡞Ʉࠬ‫ס‬൫ଢ଼ۛ৪͉΃σΣΙϋȪŤŢųůŪŵŪůŦȫࠧཋ̈́ͤͅօ̩Ȃࡔ֦̱͉͂̀Ȃӱଅ͈́΃σΣΙϋॲ୆೩‫ئ‬ȂӲ૙ম̥͈ͣ୫৾ະ௷Ȃӳ൫ଢ଼‫ס‬ಎ͈͒Ⴣ੄Ȃ̦̈́̓‫ˍ̬ͥͦͣݷ‬Īȃ΃σΣΙϋࠧཋ͉Ȃ൫ଢ଼ۛ৪අခ͈Ȃ̭͚ͣ༐ͤȂ޼ႁ೩‫ئ‬Ȃޭഽ͈࠱టۜȂ૤๬ఱȂ૤޼છȂ૤‫ܥ‬ෝ೩‫ئ‬ȂະାྤȂ൫ଢ଼ಎ͈೩ࠬգȂඏடঘ͈̈́̓อછࡔ֦͈̜֚̾́ͥ͂ࣉ̢̤ͣͦ̀ͤ ˍĪ Ȃ΀ςΑυε΀ΙϋȪņőŐȫ೷ࢯ଻ຫࠬȂ΍σ΋βΣͺȆέτͼσȂ൲ྤࣁ‫͜߸۾͈͂̓̈́ا‬ঐഊ̯̞ͦ̀ͥ㸯㸲 ȃজ̹̻͉Ȃ·ςΣΛ·̤̫ͥͅྕ଻ࠬ‫ס‬൫ଢ଼ۛ৪ͅచ̳ͥȂ΃σΣΙϋ༞ਰၷ༹͈ႉ઄࢘‫ͬض‬Ȃࢃ༷ণഎͅ࠿൦̱̹͈́༭̳࣬ͥȃɃచય༹༷͂Ʉచય͉Ȃࠬ‫ס‬൫ଢ଼‫ٳ‬ই̥ͣ˒ώ࠮ոષࠐً̱̹ۛ৪ĶĲྴȪ౳଻ĴĴྴȂ੫଻ĲĹྴȫȂාႢ͉ĶĳȡĹĺȂĸĲįĳȾĹįĵȪŮŦŢůȾŔįŅįȫपȂ൫ଢ଼‫͉ۼܢ‬ಎ؇౵ķıώ࠮Ȫ˔ȡĴĹĸώ࠮ȫ̜̹́̽ȃ
಺औ͉ĳıĳıාĲı࠮࣐̹̦̽ͅȂĳıĲĹා˕࠮́͘ஸͤ಺औ̱̹ȃ΃σΣΙϋ༞ਰၷ༹͈஖఼‫ܖ‬੔͉ȂņőŐୋस͞ഘसൎဓ́͜Ȃຫ͈ࠬ٨஝̦՛̞છ႕́Ḁ̑̾Ȃ඾ུ઀঱‫ڠش‬͈ٛঐૻˍȫͅ‫̧̿ܖ‬ȂŇųŦŦ ŤŢųůŪŵŪůŦ ĩŇńĪɃĳıЂŮŰŭŦİō ĩ΃σΣΙϋࠧཋ͂૷౯Ī ̥ƥĳıɅŇńɃĴķ̹͉͘łŤźŭŤŢųůŪŵŪůŦ ĩłńĪ İ ŇńɄıįĵ ĩ΃σΣΙϋࠧཋછ̦อ୆̳ͥ‫خ‬ෝ଻̦ޭ̞͛̀ࣞȫ͈႕̱̹͂ȃ΃σΣΙϋ༞ਰ͉ȂōĮńŢųŵŪů ĲĭıııŮŨͬ਩ˏٝȂ൫ଢ଼ਞၭশͅ୓ྤඤൎဓ̱̹ȃ࠿൦༹༷͉Ȃ΃σΣΙϋͬ˒ώ࠮ոષൎဓ̱̞̀ͥĲĶ႕͂Ȃ๱ൎဓĴķ႕́Ȃࠬ‫࠿ס‬औȂఘ଼໦໦ଢ଼࠿औȂ൲ྤࣁ‫࠿ا‬औȪńłŗŊļ ńŢųťŪŰ łůŬŭŦ ŗŢŴŤŶŭŢų ŊůťŦŹȂłŃŊļ łůŬŭŦ ŃųŢŤũŪŢŭ őųŦŴŴŶųŦŊůťŦŹȂŕŃŊļ ŕŪţŪŢŭ ŃųŢŤũŪŢŭ őųŦŴŴŶųŦ ŊůťŦŹȫ൝଼͈ୡͬ๤‫࠿ڛ‬൦̱̹ȃఘ଼໦໦ଢ଼͉ͅȂŊůŃŰťźŔĮĳıȪΨͼ΂ΑβȜΑ২ୋȫͬဥ̞Ȃ൲ྤࣁ‫࠿ا‬औ͉ͅȂŗŔĮĳıııȪέ·Θഩঊ২ୋȫͬဥ̞̹ȃൡٜࠗଢ଼͉ͅņśœˑȫĩŷŦųŴŪŰů ĲįĶĴȫͬঀဥ̱Ȃခփ‫ږ‬ၚ͉ˑĦྚྖ̱̹͂ȃɃࠫ‫ض‬ɄōĮńŢųŵŪůൎဓ͈ခྫ͂ۛ৪෸ࠊȪນˍȫ䐳౳੫๤ȂාႢȂ൫ଢ଼‫ۼܢ‬Ȃൠෂພ͞ෞࠬ‫ۯ‬વ‫଻ࠬݹ͉̹͘ٺ‬૤৖ۛ൝͈ࣣ໵৖͈ۛခྫͅခփओ͉̥̹̈́̽ȃ௙΃σΣΙϋȪŕŰŵŢŭ ŤŢųůŪŵŪůŦļ ŕńȫȂŇń̤͍͢łń͉ȂōĮńŢųŵŪůൎဓ߲̦ခփࣞͅ౵̜̹́̽ȃນˍ

/&DUWLQൎဓ͈ခྫ͂ۛ৪෸ࠊ

㠀ᢞ୚⩌ (n=36)ᢞ୚⩌ (n=15)ᢞ୚ᮇ㛫: 12 [6, 18]

P-value⏨ᛶ㻌/ ዪᛶ26 / 10

7 / 80.112

ᖺ㱋 (year䠅

71.92 ± 8.41

69.33 ± 8.32

0.321
0.118

51.0 [8.0, 277.0]

101.0 [10.0, 387.0]⢾ᒀ⑓䚷䚷䚷䚷䚷䚷䚷䠄䠉䠅㏱ᯒᮇ㛫 (month䠅

178⢾ᒀ⑓䚷䚷䚷䚷䚷䚷䚷䠄䠇䠅

197⬻⾑⟶㞀ᐖ䚷䚷䚷䚷䠄䠉䠅2813⬻⾑⟶㞀ᐖ䚷䚷䚷䚷䠄䠇䠅82⹫⾑ᛶᚰ⑌ᝈ䚷䚷㻌䠄䠉䠅

3113

⹫⾑ᛶᚰ⑌ᝈ䚷䚷㻌䠄䠇䠅

5

2

0.764
0.703
1

Dry Weight (kg)55.55 [31.60, 122.60]

48.10 [32.90, 78.00]

0.084

BMI

21.05 [15.00, 41.80]

20.20 [16.50, 27.40]

0.312

Total Carnitine (Ǎmol/L䠅

34.98 ± 9.30

324.87 ± 101.79

1.21E-21Free Carnitine (Ǎmol/L䠅

21.24 ± 6.01

193.77 ± 54.77

2.33E-23

Acylcarnitine (Ǎmol/L䠅

12.70 [7.50, 26.90]

138.95 [21.80, 210.40]

7.06E-08

0.665 ± 0.174

0.659 ± 0.153

0.917

AC/FC

ນˎ

/&DUWLQൎဓ͈ခྫ͂࠿औ଼ୡ

㠀ᢞ୚⩌ (n=36)ᢞ୚⩌ (n=15)ᢞ୚ᮇ㛫: 12 [6, 18]

P-valueHb (g/dl)

10.95 [9.50, 12.50]

10.60 [8.10, 11.90]

Fe (Ǎg/ml䠅

60.0 [28.0, 189.0]

63.0 [33.0, 8.0]

0.82

Ferritin (ng/ml䠅

87.5 [8.00, 521.0]

111.0 [16.0, 478.0]

0.733

TSAT (%)

23.65 [7.50, 86.70]

22.40 [11.80, 57.40]0.489

Alb (g/dl䠅

3.90 [3.20, 4.40]

3.80 [1.90, 4.30]

0.257

LDL-Cholesterol (mg/dl䠅

0.203

80.3 ± 28.9

90.1 ± 26.8

0.263

TG (mg/dl䠅

95.0 [29.0, 462.0]

89.0 [37.0, 236.0]

0.584

CK (IU/L)

90.0 [22.0, 580.0]

55.0 [37.0, 122.0]

0.001

Creatinine (mg/dl䠅

8.46 [5.22, 15.61]

9.11 [4.38, 13.99]

0.861

Ca(corrected) (mg/dl䠅

9.04 ± 0.70

9.18 ± 0.59

0.506

P (mg/dl䠅

5.02 ± 1.00

5.42 ± 1.63

0.288

PTH (pg/ml䠅

118.8 ± 61.6

123.7 ± 62.80.798

ǃ2MG (mg/dl䠅

24.96 ± 5.31

27.95 ± 5.37

0.074

CRP (mg/dl䠅

0.075 [0.030, 2.58]

0.070 [0.030, 0.7500]

16.631 ± 1.392

5.681 ± 1.158

0.034

2SMI (kg/m 䠅ɻɻɻɻɻɻɻɻSMI: Skeletal Muscle Index䐴ōĮńŢųŵŪůൎဓ͈ခྫ͂࠿औ଼ୡȪນˎȫōĮńŢųŵŪůൎဓ߲͉๱ൎဓ߲ͅ๤͓̀ȂńŌ͂অঠࣸ‫޼ڒ‬ၾঊତȪŔŬŦŭŦŵŢŭ ŎŶŴŤŭŦ ŎŢŴŴ ŊůťŦŹļŔŎŊȫȪŔŎŊɁঅঠࣸ‫޼ڒ‬ၾɀ૸ಿˎȫ̦ခփȪ̌ɁıįııĲȂ̌ɁıįıĴĵȫͅ೩౵̜̹̦́̽Ȃ̷͈ఈ͈࠿औ଼ୡͅခփ̈́ओ͉̥̹̈́̽ȃ䐵ōĮńŢųŵŪůൎဓ͈ခྫ͂ఘ଼໦໦ଢ଼ࠫ‫ض‬Ȫ଎ˍȫΗϋΩ·ȂηΥρσȂࣸ‫޼ڒ‬ၾ‫͍ݞ‬ŔŎŊ͉ȂōĮńŢųŵŪůൎဓ߲̦ခփȪ̌Ɂıįıĳĵƥ ̌Ɂıįıĳĵƥ ̌ɁıįıĳĴȂ̌ɁıįıĴĵȫͅ೩౵̜̹̦́̽Ȃఘডཛၾ͂ņńŘİŕŃŘȪ຾ਆ͈ঐດȫ͉Ȃၰ߲‫ͅۼ‬ခփओ͉̥̹̈́̽ȃ଎ˍ/&DUWLQൎဓ͈ခྫ͂ఘ଼໦໦ଢ଼

଎ˎ /&DUWLQൎဓ͈ခྫ͂&$9,Ȃ$%,Ȃ7%,䐶ōĮńŢųŵŪů͈ခྫ͂൲ྤࣁ‫࠿ا‬औȪńłŗŊȂłŃŊ‫͍ݞ‬ŕŃŊȫࠫ‫ض‬Ȫ଎ˎȫ൲ྤࣁ‫͈ا‬ঐດ̜́ͥńłŗŊ͉ȂōĮńŢųŵŪůൎဓ߲̦ခփ ĩ̌ɁıįııĸĪ ͅ೩౵́Ȃ൲ྤࣁ‫࣐ૺ͈ا‬͉ઁ̥̹͈̈́̽ͅచ̱Ȃ൲ྤ໾णȆ‫ޛ‬ॏ͈ঐດ̜́ͥłŃŊ͂ŕŃŊ͉Ȃၰ߲‫ͅۼ‬ခփ̈́ओ̦̥̹̈́̽ȃ䐷ōĮńŢųŵŪůൎဓ͈ຫࠬͅచ̳ͥ࢘‫ض‬Ȫ଎ˏȫōĮńŢųŵŪůൎဓஜ͈ŉţ౵͉ȂĺįĳıȾıįĺĹŨİťŭ͂೩౵̜̹̦́̽Ȃˏώ࠮ࢃ͉ͅĲĲįĲıȾĲįĳĴŨİťŭ͒͂ခփȪ̌ɃıįııĶȫͅષઌ̱Ȃ˒ώ࠮ࢃ͜ĲĲįĲĶȾĲįĲĺ̷͂ͦͬ֋঵̱̞̹̀ȃņőŐঀဥၾ͉ȂൎဓஜķĹĶıįıȾĴĵĲķįĲ࣭षౙպȪŊŖȫȂˏώ࠮ࢃķıııįıȾĵĴĳıįĶŊŖȂ˒ώ࠮ࢃĶķııįıȾĵĳĶĵįĵŊŖ͂੭șͅࡘઁ̱̹̦Ȃခփ͉̥̹́̈́̽ȃ΀ςΑυεͼ΀Ιϋ೷ࢯঐତȪņœŊȈņųźŵũųŰűŰŪŦŵŪŤœŦŴŪŴŵŢůŤŦ ŊůťŦŹȫ͉ȂōĮńŢųŵŪůൎဓஜ͉ȂĲĵįĸĺȾĹįıĴ͂ࣞ౵̜̹̦́̽ȂōĮńŢųŵŪůൎဓˏώ࠮ࢃ͉ĲĲįĵĵȾĹįĲĺƥ ˒ώ࠮ࢃ͉ĲıįĴĹȾĸįĸĹ͂೩‫̱ئ‬ƥ ˒ώ࠮ࢃ͉ခփȪ̌ɃıįııĶȫ̈́೩‫̹̜̽́ئ‬ȃ଎ˏ଎ː/&DUWLQൎဓ͈ຫࠬͅచ̳ͥ࢘‫ض‬/&DUWLQൎဓ͈60,Ȃ*ULSȂ&.ͅచ̳ͥ࢘‫ض‬ōĮńŢųŵŪůൎဓ͈ŔŎŊȂ՜ႁȪňųŪűȫ‫͍ݞ‬ńŌͅచ̳ͥ࢘‫ض‬Ȫ଎ːȫ䐸ōĮńŢųŵŪůൎဓஜࢃ́ȂŔŎŊȂňųŪű‫͍ݞ‬ńŌͅခփ̈́་‫̹̥͉̽̈́ا‬ȃ䐹ōĮńŢųŵŪůൎဓ͈ńłŗŊȂłŃŊ‫͍ݞ‬ŕŃŊͅచ̳ͥ࢘‫ض‬Ȫ଎ˑȫĳıĲĹා͂ĳıĳıා͈࠿औࠫ‫ͬض‬๤‫̹̱ڛ‬ȃ‫ۼܢ‬ඤ̤̫ͥͅōĮńŢųŵŪů͈ൎဓ͉Ȃ˒ȡĲĹώ࠮Ȫಎ؇౵Ĳĳώ࠮ȫ̜̹́̽ȃńłŗŊ͉ˎාஜ͂๤͓̀་‫͈̹̥̦̽̈́ͅا‬చ̱ȂłŃŊ͉ˎා‫́ۼ‬ခփȪ̌ɁıįıĴĵĹȫͅ೩‫̱ئ‬̞̹̀ȃŕŃŊ͜೩‫̦̹̞̱̀ئ‬ခփ͉̥̹́̈́̽ȃ଎ˑ

/&DUWLQൎဓ͈&$9,Ȃ$%,Ȃ7%,ͅచ̳ͥ࢘‫ض‬ນˏ/&DUWLQൎဓခྫ༆͈ĳıĲĹා͈࠿औ଼ୡL - Cartin

AgeAlbumin (g/dl㸧
Creatinine (mg/dl㸧
Ca (corrected) (mg/dl㸧
P (mg/dl㸧LDL Cholesterol (mg/dl㸧
TG (mg/dl㸧
CK (IU/L)CRP (mg/dl㸧
B2MG (mg/dl㸧
PTH (pg/ml㸧Hb (g/dl㸧
Ferritin (ng/ml㸧
TSAT (%)
Total Carnitine (Ǎmol/L㸧Free Carnitine (Ǎmol/L㸧
Acylcarnitine (Ǎmol/L㸧
AC/FCBMI
SMI (kg/m2䠅
Grip (kg㸧CAVI (ABIӌ0.91)
ABI
TBI( - ) n = 24
71.42 (8.20)
3.78 (0.37)
9.52 (2.87)
8.98 (0.67)
5.04 (1.46)
83.21 (34.27)
107.33 (36.73)
81.00 [28.00, 194.00]
0.03 [0.03, 2.01]
24.18 (6.47)
115.50 [23.00, 358.00]
10.70 (1.26)
63.50 [11.00, 271.00]
24.58 (9.77)
42.30 [30.50, 68.70]
28.57 (5.47)
15.05 [9.30, 33.50]
0.50 [0.40, 1.00]
20.62 (3.60)
6.21 (1.25)
26.46 (10.03)
9.24 (2.15)
1.03 [0.70, 1.17]
0.60 (0.19)( + ) n = 1065.80 (6.66)
3.77 (0.40)
10.55 (2.42)
8.98 (0.43)
5.62 (1.12)
74.40 (25.62)
83.20 (51.34)
49.50 [26.00, 137.00]
0.11 [0.03, 2.95]
27.32 (4.74)
105.00 [60.00, 155.00]
10.45 (1.19)
87.50 [11.00, 222.00]
24.30 (9.12)
39.90 [33.20, 58.30]
26.82 (5.09)
15.05 [8.80, 26.90]
0.60 [0.30, 0.90]
21.10 (3.66)
5.95 (0.89)
23.70 (9.64)
7.86 (2.19)
0.90 [0.60, 1.14]
0.57 (0.16)

P value
0.065
0.95
0.327
0.989
0.269
0.471
0.131
0.039
0.231
0.178
0.354
0.597
0.748
0.938
0.748
0.392
0.940.15
0.727
0.556
0.465
0.226
0.364
0.7

mean (S.D.), median [min, max]ōĮńŢųŵŪůൎဓခྫ༆͈ĳıĲĹා͈࠿औ଼ୡȪນˏȫ䐺ōĮńŢųŵŪůൎဓ߲͂๱ൎဓ߲͈ˎාஜȪĳıĲĹාȫ͈࠿औ଼ୡͬ๤‫̦̹̱ڛ‬Ȃၰ߲‫ͅۼ‬ခփ̈́ओ̦̜̹͈͉̽ȂńŌȪ̌ɁıįıĴĺȫ̺̫̜̹́̽ȃņőŐൎဓၾ͂ņœŊ͜ၰ߲‫ͅۼ‬ओ͉̥̹̈́̽ȃ䐻ōĮńŢųŵŪůൎဓ߲͈ĳıĲĹා͂ൎဓஜ͈ŇńȂŉţ‫͍ݞ‬ņœŊ͈๤‫ڛ‬Ȫ଎˒ȫŇń͉ȂĳıĲĹාͅĳķįĹĳȾĶįıĺ̜̹̦́̽Ȅൎဓஜ͉ĳıįĴĹȾĵįĹĸ͂ခփȪ̌ɁıįıĲĲȫͅ೩‫̱ئ‬̞̹̀ȃŉţ͉ĲıįĵĶȾĲįĲĺ̦ĺįĳıȾıįĺĹ͂೩‫࢜߹ئ‬Ȫ̌ɁıįıĶķȫͬȂņœŊ͉ĸįĵĸȾĸįĲĺ̦ĲĵįĸĺȾĹįıĴ͂ષઌ߹࢜Ȫ̌ɁıįıĶĹȫͬা̱̹ȃ଎˒

/&DUWLQൎဓஜ͈)&Ȃ+EȂ(5,Ƀࣉख़ɄōĮńŢųŵŪůൎဓ߲͉ȂൎဓஜͅŇń̦ĳĴįĲıȾĺįĶĲ ĩЂŮŰŭİōĪ ͂೩‫̤̱ͤ̀ئ‬ȂłńİŇń๤̦ıįķĸȾıįĲĸ͂ࣞ౵̜̹́̽ȃŉţ౵͉ōĮńŢųŵŪůൎဓஜȂņőŐୋस໹޳ķĭĹĶıŊŖ͈ൎဓ͜ͅ‫̴ͣͩ۾‬ĺįĳȾıįĺĹ͂೩౵́ȂņœŊ͉ĲĵįĸĺȾĹįıĴ͂ņőŐ೷ࢯ଻ͬা̱̞̹̀ȃ΃σΣΙϋ༞ਰၷ༹ͤ͢ͅȂ΃σΣΙϋ໦ْ͈ࠬಎෛഽ͉ࡐಠͅષઌ̱Ȃŉţෛഽ͉ˏώ࠮ࢃ͉ͅခփȪ̌ɃıįııĶȫͅષઌ̱̀ຫ͈ࠬ٨஝̦෇͛ͣͦȂņœŊ͉˒ώ࠮ࢃ͉ͅခփȪ̌ɃıįııĶȫͅ೩‫̱̀ئ‬ņőŐ೷ࢯ଻͈٨஝̦෇̹͛ͣͦȃ̹͘ȂņőŐঀဥၾ͜໹޳ķĭĹĶıŊŖ̥ͣ˒ώ࠮ࢃ͉ͅĶĭķııŊŖ͒͂ࡘઁ߹࢜ͬা̱̹ȃŎŢųŶźŢŮŢͣ˒ȫ͉Ȃτδ΃σΙϋĲĳώ࠮‫ۼ‬ൎဓ́Ȃŉţ౵͂ŉŵ౵͉ͅȂൎဓ߲͂๱ൎဓ߲͈͂‫́ۼ‬ओ͉ྫ̥̹̦̽Ȃ̭͈ŉţ౵͂ŉŵ౵ͬ֋঵̳͈ͥͅຈါ̈́ņŔłൎဓၾ͉Ȃൎဓ߲́ခփͅࡘઁ̱ȂņœŊ͜ခփͅࡘઁ̱̹͂༭̱̞࣬̀ͥȃ͈ࣽٝ࠿൦́͜ȂōĮńŢųŵŪůൎဓ͉ȂņőŐୋसঀဥၾͬ௩̳̭̩͂̈́͞Ȃ೩‫̹̱ئ‬ŉţ౵ͬષઌ̵̯̭̦ͥ͂া̯̹ͦȃ̹͘ȂŐŬŢŻŢŬŪͣ˓ȫ͉֋঵൫ଢ଼ۛ৪́ȂņœŊ̦Ĳıոષ̺͂୆ྵထࢃະၻ̜̭́ͥ͂ͬা̱̤̀ͤȂņųŪŨŶŤũŪͣ˔ȫࠬ͜‫ס‬൫ଢ଼൵ව‫͈ܢ‬ņœŊ̦ĺįĵĵոષ̺͂Ȃထࢃະၻ̜́ͥ͂༭̱̞࣬̀ͥȃ͈ࣽٝ࠿൦͉́ȂōĮńŢųŵŪůൎဓஜ͈ņœŊ͉Ĳĵįĸĺ͂ࣞ౵̜̹̦́̽Ȃൎဓ˒ώ࠮ࢃ͉ͅĲıįĴĹ͂೩‫̱ئ‬Ȃ΃σΣΙϋ༞ਰၷ༹͈ခဥ଻̦াऐ̯̹ͦȃ༷֚Ȃ໌ඤͣ˕ȫ͉Ȃτδ΃σΙϋ༞ਰၷ༹̦൫ଢ଼‫۾‬Ⴒ޼රછેȪྫႁછ͂޼ជᓕȫ͈٨஝ͅခ̜̹࢘́̽͂༭̱̤࣬̀ͤȂŎŢųŶźŢŮŢͣĲıȫ͉ȂōĮńŢųůŪŵŪůŦൎဓ̦՜ႁ೩‫͞ئ‬ષუ޼࿂ୟ͈ࡘઁͬཡ̬̹͂੆͓̞̀ͥȃ͈ࣽٝ࠿൦͉́ȂōĮńŢųůŪŵŪůൎဓ͉ŔŎŊȂ՜ႁȂńŌͅచ̱̀ခփ̈́࢘‫ض‬̦̥̹̈́̽ȃ̱̥̱ȂōĮńŢųŵŪůൎဓ́޼රၾ͞޼ႁ̦ခփͅࡘઁ̴̱̤̀ͣȂ΃σΣΙϋൎဓͤ͢ͅȂ޼රၾ௩‫޼͞ح‬ႁ௩‫ܢ͉ض࢘ޑ‬ఞ̧̞͈͈́̈́͜Ȃࣸ‫޼ڒ‬ၾࡘઁ͞޼ႁ೩‫ဲͬئ‬ଷ̧́ͥ‫خ‬ෝ଻̦াऐ̯̹ͦȃτδ΃σΙϋ༞ਰၷ༹͂൲ྤࣁ‫̱̀۾ͅ߸۾͈͂ا‬ȂŉŪŨŶŤũŪͣĲĲȫ͉Ȃ൫ଢ଼ۛ৪͈͒ōĮŤŢųůŪŵŪůŦȪĳıŮŨİŬŨİťŢźȫൎဓͤ͢ͅȂષუ௷ਉ‫ྤۼ‬෨ഥ෥௸ഽȪţųŢŤũŪŢŭĮŢůŬŭŦ őŶŭŴŦ ŘŢŷŦ ŗŦŭŰŤŪŵźļţŢőŘŗȫ̦Ĳĳώ࠮ࢃͅခփͅ೩‫̥̭̹̱ͣ͂ئ‬ȂōĮŤŢųůŪŵŪůŦൎဓ̦൲ྤࣁ‫͈࣐ૺا‬ထཡ̈́ͥͅ‫خ‬ෝ଻ͬাऐ̱̞̀ͥȃఆષͣĲĳȫ͉Ȃ‫ॸ؂‬τδ΃σΙΣϋȪĺııŮŨİťŢźȫͬˏώ࠮‫ۼ‬Ⴒ඾ൎဓ̱̹ࠫ‫ض‬ȂłŃŊ͂ŕŃŊ͉ͅ་‫̦̹̥̦̽̈́ا‬ȂţŢőŘŗ͉೩‫ͬ࢜߹ئ‬া̱̹͂༭̱̞࣬̀ͥȃ͈ࣽٝ࠿൦͉́ȂōĮńŢųŵŪů͈ൎဓ͉˒ȡĲĹΉ࠮Ȫಎ؇౵Ĳĳώ࠮ȫ͈ൎဓ̜̹̦́̽Ȃˎා‫ۼ‬Ȃ൲ྤ͈ࣁ̯͈ঐດ̜́ͥńłŗŊͅ་‫̥̭̹̥̦ͣ͂̽̈́ا‬Ȃ൲ྤࣁ‫خ̢̹̞̀ဲ࣐ͬૺ͈ا‬ෝ଻̦াऐ̯̹ͦȃ̱̥̱Ȃ൲ྤ͈໾णȆ‫ޛ‬ॏ͈ঐດ̜́ͥłŃŊ͉೩‫̤̱ͤ̀ئ‬Ȃ൲ྤ‫ޛ‬ॏ͞໾ण͈ૺ࣐ဲଷ͉́͘Ȃ‫ܢ‬ఞ̧̞͈͉̞̥́̈́́̈́͂ࣉ̢̹ͣͦȃɃࠫࢊɄ䐳ōĮńŢųŵŪůൎဓͤ͢ͅȂņőŐୋस͈௩ၾ̱̈́ͅŉţ̦ષઌ̱ȂņőŐ೷ࢯ଻̦٨஝̱̹ȃ䐴ŉţ̦೩‫̱̀ئ‬ņőŐ೷ࢯ଻͈̜ͥۛ৪ͅచ̱ȂōĮńŢųŵŪůൎဓ࣐ͬ̽̀͜Ȃ೩‫̹̱ئ‬ŔŎŊ͞՜ႁͬ٨஝̵̯ͥ࢘‫̹̥͉̽̈́ض‬ȃōĮńŢųŵŪůൎဓͤ͢ͅȂńłŗŊ౵͉ˎා‫ۼ‬་‫̹̥̦̽̈́ا‬ȃ䐵Ƀ၌‫ף‬௖฽͈‫ٳ‬াɄಠ৪ུͅა໲ͅ‫ٳ̱̀۾‬া̧̳͓၌‫ף‬௖฽ેఠ͉̞̈́ȃɃ໲ࡃɄˍȫպനෆȂ‫ॄ܊‬ဉহȂඤനࠃ֚Ȃఈȇȸ΃σΣΙϋࠧཋછ͈૷౯Ȇহၷঐૻ ĳıĲĹȹ٨ୃŘňȂ඾ུ઀঱‫ڠش‬ٛγȜθβȜΐȂŸŸŸįūűŦťŴįŰųįūűİŶűŭŰŢťŴİŧŪŭŦŴİĳıĲĹĲĳıĸŠŴũŪŴũŪůįűťŧˎȫऎಎ঒ȇ΃σΣΙϋȽ൫ଢ଼ۛ৪̤̫ͥͅ΍σ΋βΣͺȆέτͼσ͈อછͅஆहഎͅ‫۾‬ဓ̳ͥ൫ଢ଼΃σΣΙϋࠧཋછȂଅ͂൫ଢ଼ ĹıȇĸĴĲ㻙ĸĴĵȂĳıĲķȅˏȫŌŢŮŢťŢ Śĭ ŎŢŴŶťŢ ŕĭ ŌŰŵŢůŪ Ōĭ Ŧŵ ŢŭįĻ ŅŦŤųŦŢŴŦť ŭŦŷŦŭ Űŧ ŴŦųŶŮ ŤŢųůŪŵŪůŦ ŮŪŨũŵ
ŭŦŢť ŵŰ ŢųŵŦųŪŰŴŤŭŦųŰŴŪŴ űųŰŨųŦŴŴŪŰů ŷŪŢ ŵũŦ ŢŤŤŶŮŶŭŢŵŪŰů Űŧ ŢťŷŢůŤŦť ŨŭźŤŢŵŪŰů ŦůťűųŰťŶŤŵŴ Ūů ŮŢŪůŵŦůŢůŤŦ ũŦŮŰťŪŢŭźŴŪŴ űŢŵŪŦůŵŴį œŦůŢŭ œŦűŭŢŤŦŮŦůŵ ŕũŦųŢűź ĴĻ ĶĸĭŅŐŊ ĲıįĲĲĹķİŴĵĲĲııĮıĲĸĮıĲĴĶĮķĭ ĳıĲĸįːȫෝഴࢤ࢕ȂෝഴदȂෝഴໍȂఈȇࠬ‫ס‬൫ଢ଼ۛ৪͈΃σΣΙῧέτͼσȂ΍σ΋βΣͺ‫ݞ‬͍൲ྤࣁ‫࠿̳ͥ۾ͅا‬൦Ȃਝനଅະ஠ࡄ‫ݪ‬ٛধ ĳĴȇĲĳĹ㻙ĲĴĶȂĳıĳıȅˑȫŌŢůťŢ ŚĻ ŊůŷŦŴŵŪŨŢŵŪŰů Űŧ ŵũŦ ŧųŦŦŭź ŢŷŢŪŭŢţŭŦ ŦŢŴźĮŵŰĮŶŴŦ ŴŰŧŵŸŢųŦ 䇺ņśœ䇻 ŧŰųŮŦťŪŤŢŭ ŴŵŢŵŪŴŵŪŤŴį ŃŰůŦ ŎŢųųŰŸ ŕųŢůŴűŭŢůŵŢŵŪŰů ĵĹĻ ĵĶĳ㻙ĵĶĹĭ ĳıĲĴį˒ȫŎŢųŶźŢŮŢ ŕĭ ŉŪŨŶŤũŪ ŕĭ ŚŢŮŢŻŢŬŪ ŕĭ Ŧŵ ŢŭįĻ ōŦŷŰŤŢųůŪŵŪůŦ ŊůūŦŤŵŪŰůŴ ŅŦŤųŦŢŴŦ ŵũŦŏŦŦť ŧŰų ņųźŵũųŰűŰŪŦŴŪŴĮŔŵŪŮŶŭŢŵŪůŨ łŨŦůŵŴ Ūů ŉŦŮŰťŪŢŭźŴŪŴ őŢŵŪŦůŵŴ ŸŪŵũ œŦůŢŭłůŦŮŪŢį ńŢųťŪŰųŦůŢŭ ŎŦťį ĸĻ ĲĹĹ㻙Ĳĺĸĭ ĳıĲĸį
˓ȫŐŬŢŻŢŬŪ Ŏĭ ŌŰŮŢŵŴŶ Ŏĭ ŌŢŸŢŨŶŤũŪ ŉĭ Ŧŵ ŢŭįĻ ņųźŵũųŰűŰŪŦŵŪů ųŦŴŪŴŵŢůŤŦ ŪůťŦŹ ŢůťŵũŦ ŢŭŭĮŤŢŶŴŦ ŮŰųŵŢŭŪŵź Űŧ ŤũųŰůŪŤ ũŦŮŰťŪŢŭźŴŪŴ űŢŵŪŦůŵŴį ŃŭŰŰť őŶųŪŧ ĴĸĻĲıķ㻙ĲĲĳĭĳıĲĵȅ˔ȫņųŪŨŶŤũŪ œĭ ŕŢůŪŨŶŤũŪ Ŏĭ ŏŪůŰŮŪźŢ ŕĭ Ŧŵ ŢŭįĻ ŉźűŰųŦŴűŰůŴŪŷŦůŦŴŴ ŵŰ ŦųźŵũųŰűŰŪŦŴŪŴĮ
ŴŵŪŮŶŭŢŵŪůŨ ŢŨŦůŵ ŢŴ Ţ űųŰŨůŰŴŵŪŤ ŧŢŤŵŰų Ūů ŋŢűŢůŦŴŦ ũŦŮŰťŪŢŭźŴŪŴ űŢŵŪŦůŵŴĻ ŵũŦ ŒĮńŰũŰųŵ ŴŵŶťźį ŋ ŏŦűũųŰŭ ĳĹĻ ĳĲĸ㻙ĳĳĶĭ ĳıĲĶį˕ȫ໌ඤௌȂୄࡔ৘୷యȂ಴നฎ໲Ȃఈȇࠬ‫ס‬൫ଢ଼ۛ৪ͅచ̳ͥτδ΃σΣΙϋ༞ਰၷ༹Ȃ൫ଢ଼ٛধ ĵĶȇĺĶĶ㻙ĺķĴȂĳıĲĳįĲıĪ ŎŢųŶźŢŮŢ ŕĭ ŎŢųŶźŢŮŢ ŏĭ ŉŪŨŶŤũŪ ŕĭ Ŧŵ ŢŭįĻ ņŧŧŪŤŢŤź Űŧ ōĮŤŢųůŪŵŪůŦ ŴŶűűŭŦŮŦůŵŢŵŪŰůŧŰų ŪŮűųŰŷŪůŨ ŭŦŢů ţŰťź ŮŢŴŴ Ţůť űũźŴŪŤŢŭ ŧŶůŤŵŪŰů Ūů űŢŵŪŦůŵŴ Űů ũŦŮŰťŪŢŭźŴŪŴĻ ŢųŢůťŰŮŪŻŦť ŤŰůŵųŰŭŭŦť ŵųŪŢŭį ņŶų ŋ ńŭŪů ŏŶŵų ĸĴĻ ĳĺĴ㻙ĴıĲĭ ĳıĲĺįĲĲĪ ŉŪŨŶŤũŪ ŕĭ łţŦ Ŏĭ ŚŢŮŢŻŢŬŪ ŕĭ Ŧŵ ŢŭįĻ ņŧŧŦŤŵŴ Űŧ ōŦŷŰŤŢųůŪŵŪůŦ Űů ŃųŢŤũŪŢŭĮłůŬŭŦ
őŶŭŴŦ ŘŢŷŦ ŗŦŭŰŤŪŵź Ūů ŉŦŮŰťŪŢŭźŴŪŴ őŢŵŪŦůŵŴĻ ł œŢůťŰŮŪŻŦť ńŰůŵųŰŭŭŦť ŕųŪŢŭįŏŶŵųŪŦůŵŴ ķĻ Ķĺĺĳ㻙ķııĵĭ ĳıĲĵįĲĳĪ ఆષ࢚໲Ȃ൸࢛ഓȂ‫ح‬൥େ૽ȇ໾ण଻൲ྤࣁ‫ا‬છۛ৪̤̫ͥͅōĮ΃σΣΙϋ༞ਰၷ༹͈࠿൦Ȃྤ‫ ڠۯ‬ĶĶȇĲĲĸ㻙ĲĳĴȂĳıĲĶį