HEALTH - FOOD

N AT U R A L A C H E R E L I E FMITIDOLZINGIBER AND ACMELLAS TA N D A R D I Z E D E X T R A C T S C O M B I N AT I O NPlease note this documentation is available for various countries all over the world and hence it may containstatements or product classification not applicable to your country. The claims made are in reference to ingredients
only, hence they do not refer to finished products and they may not comply with Regulation EC n. 1924/2006.
The marketer of any finished product containing any ingredient is responsible for assuring that thedestination of the product and the claims made for the finished product are lawful and comply withall applicable laws and regulations of the country or countries in which the product is to be sold.

®

Zingiber officinale and Acmella oleracea
effective as natural adjuvant in achemanagement.

SPECIFICATIONSMITIDOL® is standardized to contain:
9.6-11.8% Zingiber officinale CO2 extract(2.4-3.9% total gingerols and shogaols by HPLC)
1.9-2.4% Acmella oleracea st. extract(0.30-0.60% spilanthol by HPLC)SCIENTIFIC EVIDENCE
MITIDOL® is supported by a human efficacy
study, and two in vitro mechanistic studies.

SUGGESTED USE AND DOSEMITIDOL® is a yellowish fine powder withgood technological properties (e.g. density,flowability), easy to formulate and mainly
suitable for capsules and tablets.
Suggested dose: 350 mg twice a day

References
1International patent application WO2018/108549
2
Dugasani, Swarnalatha, et al. Journal of ethnopharmacology 127.2 (2010): 515-520.
3
Dedov, Vadim N., et al. British journal of pharmacology 137.6 (2002): 793-798.
4
Grzanna et al. Journal of medicinal food 8.2 (2005): 125-132.
5Kiuchi, Fumiyuki, et al. Chemical and Pharmaceutical Bulletin 40.2 (1992): 387-391.
6
Tjendraputra, Effie, et al. Bioorganic chemistry 29.3 (2001): 156-163.
7Dubey, Suchita, et al. Advances in pharmacological sciences 2013 (2013).
8
Rondanelli, Mariangela, et al. Fitoterapia (2019): 104419.
9
Wu L-C et al. J Agric Food Chem. 2008;56(7):2341-2349
10Bakondi, Edina, et al. International journal of molecular sciences 20.17 (2019): 4308.
11
Rondanelli M., et al. Pain Medicine (2019)12Indena manuscript in preparation
13
Indena manuscript in preparation

MITIDOL® is a proprietary1 association of two
standardized botanical extracts able to supportache management.
The innovative composition exploits the propertiesof two traditionally used plants:• Zingiber officinale- gignerols and shogaols are the main extract
components;- traditionally used, the plant has a vast scientific
literature, with studies documenting their ability
to modulate many enzymes involved in thehealthy inflammatory response;2-6

DPR0299 - 12/2019

standardized botanical extracts, namely• Acmella oleracea- Indena proprietary organic plantations in Sardinia;- fully sustainable source of alkylamides;- compliant to main worldwide regulations;- the main component, spilanthol, is effective
at low dosages and in literature has shown aplethora of beneficial effects.7-10
A one-month human efficay study on joint
challenges on MITIDOL® showed:11• optimization of knee functionality confirmed in
two different tests: Lhysolm and Womac scale• effective on knee ache intensity
already after 10 days of supplementation• improvement in Quality of Life score(SF-36 questionnaire)• improvement in physical activity• healthy oxidative response control,
possibly causing inflammation:-12.7% Erythrocyte Sedimentation Rate
-36.4% high sensitivity CRP
Two mechanistic studies suggested that, ,MITIDOL® could selectively act on cannabinoid
CB2 receptors compared to competitors
like Piper nigrum, Commiphora mhirra andpalmitoylethanolamide, and as a possible FAAH
inhibitor.12,13

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trademarks of Indena S.p.A. © 2019, Indena S.p.A.

is a formulation of two

WHAT MAKES MITIDOL® UNIQUE?

,MITIDOL®

® TM

WHAT IS MITIDOL®?