“The 1st International Symposium on Mucosal Immunityand Vaccine Development 2014”

Kick-Off Lecture by Nobel Laureate in Physiology orMedicine -Prof. Bruce A. Beutler
Date:

October 17 (Fri), 2014

Place: First Building Auditorium, Institute of Medical Science, The University ofTokyo
Organizer: International Research and Development Center for Mucosal Vaccines,
Institute of Medical Science, The University of Tokyo (IMSUT)
Chair:

Hiroshi Kiyono (IMSUT)

Committee members: Satoshi Uematsu (IMSUT), Koji Hase (IMSUT), Shintaro Sato(IMSUT)
Sponsor: MEDICAL & BIOLOGICAL LABORATORIES CO.,LTD. (MBL)
Program:

October 17 (Fri)13:30-13:35 Welcome remarks	 

Hiroshi Kiyono (Dean, IMSUT)

13:35-13:40 Opening remarks

Naoki Kimura (Director, Scientific Research Institutes
Division, Research Promotion, Bureau, Ministry ofEducation, Culture, Sports, Science and Technology)

13:45-13:50 Sponsor announcement Jun Sasaki (CEO, MBL)
13:50-15:20 Lecture

Prof. Bruce A. Beutler

15:20-15:33 Coffee Break
15:33-16:05 Q&A Session
16:05-16:15 Closing Remarks

1Prof. Bruce A. Beutler
Director, Center for the Genetics of Host Defense, Univerity ofTexas Southwestern(Biography)
Bruce Beutler, MD, discovered an important family of receptors that allow mammals tosense infections when they occur, triggering a powerful inflammatory response. For thiswork he received the 2011 Nobel Prize in Physiology or Medicine.
Beutler received his undergraduate degree from the University of California at San
Diego in 1976, and his MD degree from the University of Chicago in 1981. After twoyears of residency at the University of Texas Southwestern Medical Center, he became
a postdoctoral fellow and then an Assistant Professor at the Rockefeller University(1983-1986), where he isolated mouse tumor necrosis factor (TNF), and was the first torecognize TNF as a key executor of the inflammatory response. Returning to Dallas in1986 as an HHMI investigator, he designed recombinant inhibitors of TNF that arewidely used in the treatment of rheumatoid arthritis and other inflammatory diseases.
He also used TNF as a biological endpoint in order to identify the receptor for bacterial
lipopolysaccharide (LPS). This he achieved by positionally cloning the Lps mutation ofmice, known to prevent all biological responses to LPS, including TNF production. Hethus concluded that Toll-like receptor 4 (TLR4) acts as the signaling core of the LPS
receptor and proposed that other TLRs might also recognize conserved molecularsignatures of infection.
Moving in 2000 to the Scripps Research Institute, Beutler developed the largest mouse
mutagenesis program in the world, and applied a forward genetic approach to decipher
the signaling pathways activated by TLRs. He also identified many other moleculeswith non-redundant function in the immune response.

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Beutler is currently a Regental Professor and Director of the Center for Genetics of Host
Defense at the University of Texas Southwestern Medical Center. He also holds theRaymond and Ellen Willie Distinguished Chair in Cancer Research in honor of Laverne
and Raymond Willie, Sr. He has authored or co-authored more than 300 papers, whichhave been cited more than 46,000 times. Before he received the Nobel Prize, his work
was recognized by the Shaw Prize (2011), the Albany Medical Center Prize in Medicineand Biomedical Research (2009), election to the National Academy of Sciences andInstitute of Medicine (2008), the Frederik B. Bang Award (2008), the Balzan Prize(2007), the Gran Prix Charles-Leopold-Mayer (2006), the William B. Coley Award(2005), the Robert-Koch-Prize (2004), and other honors.
(Educations)
Undergraduate University of California-San Diego (1976)
Medical School University of Chicago (1981), Medicine(Honors/Awards)
Nobel Prize in Physiology or Medicine (2011)
Shaw Prize (2011)
National Academy of Science (2008)
Balzan Prize (2007)
Gran Prix Charles-Leopold Mayer from the Academie des Sciences in France (2006)

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Ito International Research Center (IIRC) Symposium,
The University of Tokyo“The 1st International Symposium on Mucosal Immunity
and Vaccine Development 2014”
Date: October 20 (Mon) -21 (Tue), 2014
Place: Lecture: Ito Hall, Ito International Research Center, The University of Tokyo
Mixer: Event Space, Ito International Research Center, The University ofTokyoOrganizer: International Research and Development Center for Mucosal Vaccines,
Institute of Medical Science, The University of Tokyo (IMSUT)
Chair: Hiroshi Kiyono (IMSUT)
Committee members:
Satoshi Uematsu (IMSUT)
Koji Hase (IMSUT)
Shintaro Sato (IMSUT)
Program:

Day 1: October 20 (Mon)13:30 Opening remarks	  Hiroshi Kiyono

Session I: Immune response and Barrier functions on Mucosal Surface
Chairs: Hiroshi Ohno (RIKEN IMS)
Satoshi Uematsu (IMSUT)
13:40-17:40
1.

Sidonia Fagarasan
RIKEN Center for Integrative Medical Sciences (IMS), Yokohama,
Kanagawa, Japan

2.

Gregory SonnenbergDivision of Gastroenterology, Department of Medicine, Perelman School ofMedicine, University of Pennsylvania, Philadelphia, PA, USA

3.

Kiyoshi Takeda
Laboratory of Immune Regulation, Department of Microbiology andImmunology, Graduate School of Medicine, Osaka University, Suita, Osaka,Japan(15:10-15:30 Coffee brake)4

4.

Ken Cadwell
Kimmel Center for Biology and Medicine at the Skirball Institute, New York
University School of Medicine, New York, NY, USA

5.

Won-Jae LEE
School of Biological Science, Seoul National University, Seoul, South Korea

6.

Satoshi Uematsu
Division of Innate immune regulation, International Research andDevelopment Center for Mucosal Vaccine, IMSUT, Minato-ku, Tokyo,Japan

7.

(*Short talk#1) Naoko Satoh-Takayama
Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris,France

8.

(*Short talk#2) Tomokazu OHTAWPI Immunology Fontier Research Center, Osaka University, Japan

18:00

Mixer

Day 2: October 21 (Tue)

Session II: Host-microbe interaction on Health and Diseases
Chairs: Toshinori Nakayama (Chiba Univ.)
Masahira Hattori (Univ. of Tokyo)
9:00-12:00
1.

Julie K. Pfeiffer
Department of Microbiology, University of Texas Southwestern MedicalCenter, Dallas, Texas, USA2.

Kenya Honda
RIKEN IMS-RCAI, Yokohama, Kanagawa, Japan

3.

Naoko Ohtani
Foundation for Cancer Research Division of Cancer Biology, Cancer
Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan(10:30-10:50 Coffee brake)
4.

Takuji Yamada
Department of Biological Information, Tokyo Institute of Technology Graduate
School of Bioscience and Biotechnology

5.

Koji Hase
Division of Mucosal Barriology, International Research and Development
5Center for Mucosal Vaccine, IMSUT, Minato-ku, Tokyo, Japan

6.

(*Short Talk#3 ) Lena Takayasu
Graduate School of Frontier Sciences, The University of Tokyo, Japan

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(*Short Talk#4) Mitsuharu Matsumoto
Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd. Tokyo,Japan

12:30 Lunch BreakSession III: New Strategy for Mucosal Vaccine Development
Chairs: Kiyoshi Takatsu (Toyama Univ.)
Tetsuro Matano (IMSUT)
13:30-17:30
1.

Mi-Na Kweon
Department of Convergence Medicine, University of Ulsan College ofMedicine/Asan Medical Center, Seoul, Korea

2.

Ken Ishii
Laboratory of Adjuvant Innovation, National Institute of Biomedical
Innovation, Ibaraki, Osaka, Japan

3.

(*Short Talk#5) Akiko Yonekawa
Division of Molecular Immunology, Medical Institute of Bioregulation,Kyushu University, Japan4.

(*Short Talk#6) Shinichiro Sawa
Department of Immunology Graduate School of Medicine and Faculty ofMedicine, The University of Tokyo(15:30-15:50 Coffee Brake)
5.

Hiroshi Kiyono
Division of Mucosal Immunology, IMSUT, Minato-ku, Tokyo, Japan

6.

David W. Pascual
Department of Infectious Diseases and Pathology, College of Veterinary
Medicine, University of Florida, FL, USA

7.

Jun Kunisawa
Laboratory of Vaccine Materials, National Institute of Biomedical
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Innovation, Ibaraki, Osaka, Japan
17:30 Nature Immunology Award** ceremony
17:45 Closing remarks* Short talk (20 min) speakers will be selected from submitted abstracts.
** Nature Immunology Award will be awarded by courtesy of Nature Immunology. Thewinner will be selected from the short talk speakers.

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