Press Release
September 12, 2019SANGI'S APAPRO® REMINERALIZING PROFESSIONAL TREATMENT PASTE& APAGARD RIN-SU® ORAL RINSE TO LAUNCH IN THE EU
Following the successful entry of its premium brand toothpastes APAGARD and APADENT into the EU market
in 2018, SANGI Co., Ltd. of Japan, pioneer of the world's first hydroxyapatite remineralizing toothpastes in the1980s, is now launching its professional-use enamel restorative treatment paste APAPRO, starting this month, andits newly developed oral rinse APAGARD RIN-SU, starting in November, in the EU.
Both products contain SANGI's original hydroxyapatite ingredient <mHAP®>, which was approved as ananti-caries agent by Japanese health authorities as early as 1993, and has been used in toothpastes in Japanfor almost 40 years, with over 130 million tubes sold. Both will be available in the EU through SANGI's Europeansubsidiary, SANGI Europe GmbH, located in Eppertshausen, Germany.
APAPRO remineralizing treatment paste is designed for use in dental clinics and has a high concentration of
the ingredient <mHAP>. The paste may be applied to the teeth with a rubber cup fitted to a dental handpiece,
or in a retainer tray, including for home use by the patient under the clinician's direction, and is used to supply
mineral to the teeth and restore microscopically damaged or demineralized tooth enamel, for example after
dental procedures such as scaling, bleaching or debonding, all of which can cause microscopic damage to theteeth. APAPRO is also useful for general maintenance, by supplying mineral, and over time has been shown toreduce white spot lesions (areas of demineralization below the tooth surface) and to help protect against root
caries in highly exposed teeth.
SANGI's APAGARD RIN-SU oral rinse is a hydroxyapatite mouthwash, which can be used at any time to help
maintain a healthy oral bacterial flora, by adhering to and reducing the level of harmful bacteria such as
Streptococcus mutans and other oral pathogens, protecting against caries and leaving the mouth feelingrefreshingly clean.
Established in 1974, SANGI conceived the idea of remineralizing toothpaste using hydroxyapatite – the same
substance as our teeth – after acquiring a patent from the US National Aeronautics and Space Authority (NASA),
which was seeking ways to replace mineral lost from the bones and teeth of astronauts during space missions ina gravity-free environment. SANGI launched the first hydroxyapatite-containing toothpaste, APADENT, in 1980,
followed by a second brand, APAGARD, in 1985. Its remineralizing toothpastes are high-end, premium products,occupying just on 7% of the total toothpaste market in Japan, and over the past 10 years have enjoyed growing
export sales in markets in Russia, Canada, China and Southeast Asia, and now more recently in the EU.
<mHAP's> approval in Japan as an anti-caries agent came as a result of early laboratory research in the1970s and 80s, as well as field trials conducted over a number of years in Japanese schools. Children using thehydroxyapatite toothpaste once daily over a period of 1-3 years showed a reduction in new caries of up to 3656% in some groups, compared with placebo toothpaste controls. The ingredient was named Medical
Hydroxyapatite by Japanese health authorities to distinguish it from other forms of hydroxyapatite such as dental
abrasives, and three anti-caries functions were officially recognized: (1) adsorption of plaque and plaquebacteria during toothbrushing, (2) filling and repair of microfissures on the tooth surface, and (3) remineralizationof demineralized areas below the surface of the teeth, i.e. of incipient caries lesions, the precursor of tooth decay.
Subsequent laboratory and clinical research has shown that <mHAP> also occludes and forms a coating over
exposed dentinal tubules, alleviating and protecting against painful hypersensitivity.

SANGI Co., Ltd.

SANGI Europe GmbH

3-11-6 Tsukiji, Chuo-ku
Tokyo 104-8440, JAPAN
Tel.+81-3-3545-5700
www.sangi-co.com www.apagard.com
Dominik Demel
Overseas Relations Manager
dominik@sangi-j.co.jp

Im Niederfeld 6
D-64859 Eppertshausen, GERMANY
Tel.+49-6071-39 36 35 2
www.sangi-eu.com
Jochen FreibertMarket Development & Regulatory Affairs
jfreibert@sangi-eu.com

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By supplying mineral to the teeth – just as our saliva constantly does – <mHAP> also improves the density andtranslucency of tooth enamel, so that over time, the natural gloss and whiteness of the user's teeth can be steadily
restored. In Japan and other countries <mHAP> is provided in nanoparticle form, but SANGI's products in the EU
are currently supplied with the non-nano variety.
SANGI's original hydroxyapatite oral care products are currently available in Europe via PROFIMED s.r.o. in
Czech, supplying Eastern Europe, Sanacorp Pharmahandel GmbH and Hageda-Stumpf GmbH & Co. KG in
Germany, for supply exclusively to German pharmacies, and PC Pack&Carry GmbH in Germany, supplying inparticular the dental professional route. The APAGARD range comprises APAGARD M-plus, a standard version
for family use; APAGARD SMOKIN,' containing additional ingredients for removal of stains caused by tobacco,etc.; and APAGARD PREMIO, the most popular product in SANGI's line-up, containing a higher concentration of<mHAP> than its sister products. SANGI'S APADENT range comprises APADENT TOTAL CARE, providing all-roundprotection not only from caries but also from periodontal disease; APADENT SENSITIVE, offering the same benefits,
but with the addition of hypersensitivity relief; and APADENT KIDS, also containing a higher concentration of<mHAP>, but with fewer additional ingredients and less foaming action than adult toothpastes, and including thenon-acid-producing sweetener xylitol, specifically designed for children's anti-caries use.
All SANGI's hydroxyapatite oral care products offer an alternative approach to tooth remineralization, andtherefore no fluoride is contained.
Announcing the new product launch, SANGI's president and the managing director of its EU subsidiary Roslyn
Hayman said "We are excited to be extending SANGI's EU product range, and in close collaboration with our EU
sales partners, we look forward to achieving the same customer satisfaction in Europe with our high quality
products as we currently enjoy in Japan."

APAPRO (55g)
Available from September 2019

APAGARD RIN-SU (380ml)
Available from November 2019

For further information, please contact Jochen Freibert (Germany) or Dominik Demel (Japan)
in either English or German, by telephone or email , at the addresses below, or email
info@sangi-eu.com.

SANGI Co., Ltd.

SANGI Europe GmbH

3-11-6 Tsukiji, Chuo-ku
Tokyo 104-8440, JAPAN
Tel.+81-3-3545-5700
www.sangi-co.com www.apagard.com
Dominik Demel
Overseas Relations Manager
dominik@sangi-j.co.jp

Im Niederfeld 6D-64859 Eppertshausen, GERMANY
Tel.+49-6071-39 36 35 2
www.sangi-eu.com
Jochen FreibertMarket Development & Regulatory Affairs
jfreibert@sangi-eu.com

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PRODUCT LINE-UP
Sangi produces a wide range of toothpastes, including for professional and OEM use, all of which containits proprietary anticaries remineralizing agent <mHAP>, and either zero or minimal abrasives. Most havea mild mint flavor. Tubes are made from content-protecting aluminum laminate, in most cases with a twoway screw-on / one-touch cap.
Sangi’s product line up in the EU, under the ‘APAGARD, APADENT and APAPRO brands, includes thefollowing products.
APAGARD® : Anticaries & Restorative Whitening (Cosmetic)
These products also contain a pearl ingredient, liquid conchiolin, for added luster and gloss.

NEWAPAGARD M-plus 125g
Classic standard type.
Higher volume for familyuse.
Mild mint flavor.

APAGARD PREMIO 100g
Premium type.
Higher <mHAP> content
than the others, forgreater natural whitening
and anticaries effect.
Double mint flavor.

APAGARD SMOKIN’ 100g
Stain care type.
Added ingredients (PEGand PVP) for extra
protection against stains(wine, coffee, tobacco etc).
Mild mint flavor.

APADENT® : Anticaries, Antigingivitis, Antisensitivity

APAGARD RIN-SU 380ml
Oral Rinse.
Helps to reduce plaqueand plaque-bacteria.
For healthy teeth, fresh
breath and an ultraclean feeling in the mouth.
Mild mint flavor

APAPRO®
Professional Treatment PasteNEWAPADENT TOTAL CARE 60g
For total care of the teethand gums, protecting
against caries andperiodontal disease.
Mild mint flavor.

APADENT SENSITIVE 60g
Contains both <mHAP>
and potassium nitrate fordouble relief fromhypersensitivity.
Japanese citrus mint flavor.

APADENT KIDS 60g
Adjusted for kids’
anticaries use. Contains<mHAP>, but no SLS orfluoride. Low foaming type,also containing the natural
sweetener xylitol.
Strawberry grape flavor.

APAPRO 55g
For professional use.
High concentration of<mHAP>. Repairs andremineralizes tooth enamel.
Applied with a rubber cup
or retainer tray.
Peach flavor.

SANGI Co., Ltd.

SANGI Europe GmbH

3-11-6 Tsukiji, Chuo-ku
Tokyo 104-8440, JAPANTel.+81-3-3545-5700
www.sangi-co.com www.apagard.com
Dominik DemelOverseas Relations Manager
dominik@sangi-j.co.jp

Im Niederfeld 6D-64859 Eppertshausen, GERMANY
Tel.+49-6071-39 36 35 2
www.sangi-eu.com
Jochen FreibertMarket Development & Regulatory Affairs
jfreibert@sangi-eu.com

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