Lien Se Lankstaanskoene The Full
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Other videos in collection References External links Lien se lankstaanskoene (in Afrikaans) Lien se lankstaanskoene (inAfrikaans) Lien se lankstaanskoene (in Afrikaans) Category:1994 books Category:South African poetry Category:Afrikaans
poetry Category:Afrikaans-language literatureRegulation of Tumor Necrosis Factor (TNF) and other cytokine and chemokine
networks is of great importance for normal inflammatory responses and for the survival of neoplastic cells in the context ofmalignant tumors. Recent studies have also established a role for cytokines in the pathophysiology of disorders of the CNS. Thisis true in the context of many CNS lesions, including multiple sclerosis, AIDS encephalopathy, ischemia, trauma andmalignancy. This program project focuses on the regulation of tumor necrosis factor (TNF) and other cytokine and chemokine
networks in pathologic conditions of the CNS, and the roles of these molecules in malignancy. The major goals are to define thebiologic characteristics of TNF, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), and cytokines, chemokines,
and related receptors that may help to define their roles in tumor biology, and the pathophysiology of diseases of the nervoussystem. The program is supported by four core laboratories which will permit the centralization of technical and administrative
functions, as well as the technical support required for conducting the scientific projects. Dr. Emil "Tom" Apfel (core A) will
direct a grant to study acute and chronic inflammatory responses, particularly with respect to the appearance of reactive glial
cells and glial cytokines. Dr. Werner Parrino (core B) will direct a grant to study TNF, IL-1, TGFB and other cytokines,chemokines, and related receptors, particularly in the context of malignant gliomas. Dr. Eva Boras (core C) will direct a grant tostudy the role of cytokines and chemokines in infection and immunity, particularly with respect to their ability to regulate theexpression and secretion of class I MHC proteins, antigen processing and presentation to T cells. Dr. Gail R. Brown (core D)
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