HEALTH - FOOD

H E A LT H Y C A R D I O V A S C U L A R F U N C T I O N

LEUCOSELECTPHYTOSOMEG R A P E

S E E DE X T R A C T

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only, hence they do not refer to finished products and they may not comply with Regulation EC n. 1924/2006.
The marketer of any finished product containing any ingredient is responsible for assuring that thedestination of the product and the claims made for the finished product are lawful and comply withall applicable laws and regulations of the country or countries in which the product is to be sold.

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WHAT IS LEUCOSELECT® PHYTOSOME®?
LEUCOSELECT®

PHYTOSOME®

isa

standardized grape seed extract richin oligomeric proanthocyanidins (OPC),
specificallydesignedfor

WHAT MAKES LEUCOSELECT® PHYTOSOME® UNIQUE?

supporting

LEUCOSELECT® is extracted only from Vitis
vinifera L. seeds and has well-defined chemicalcomposition1:

protection from oxidative stress relatedchallenges.
SPECIFICATIONSLEUCOSELECT®

PHYTOSOME®

isan association between grape seed
standardized extract and lecithin (fromnon-GMO soy). It is characterized by a very
specific HPLC profile, a very high content
of smaller size OPCs, and is standardized
to contain:≥25% ≤36% of proanthocyanidins (OPC)
by GPCRECOMMENDED USE AND DOSELEUCOSELECT® PHYTOSOME® is a darkbrown powder and may be utilized in avariety of supplement formulations.

• 15% (+)-catechin, (-)-epicatechin• 80% (-)-epicatechin gallate, dimers, trimers,
tetramers and their gallates• 5% pentamers, hexamers, heptamers andtheir gallates

DPR 0228 - 11/2013*10/2019

healthy cardiovascular function, andThe high content (80%) of smaller size OPCs
is critical for bioactivity, since the absorption ofprocyanidins decreases with the oligomerization
degree. It is formulated with Phytosome®
technology for optimized bioavailability,
creating LEUCOSELECT® PHYTOSOME®.
LEUCOSELECT® PHYTOSOME® is useful for
cardiovascular health particularly due to theincrease of antioxidant defenses. The humanstudies show that this ingredient can:trademarks of Indena S.p.A.

References
1Gabetta B., Fuzzati N., Griffini A., Lolla E., Pace R., Ruffilli T.,
Peterlongo F., Fitoterapia Apr 71(2): 162-75 (2000).
2Nuttal S.L., Kendall M.J., Bombardelli E., Morazzoni P., J. Clin. Pharm.
Ther. 23, 385 (1998).
3
Natella F., Belelli F., Gentili V., Ursini F., Scaccini C., J. Agric. Food
Chem. 50, 7720 (2002).
4
Vigna G.B., Costantini F., Aldini G., Carini M., Catapano A., SchenaF., Tangerini A., Zanca R., Bombardelli E., Morazzoni P., Mezzetti
A., Fellin R., Maffei Facini R., Metabolism 52, 1250 (2003).
5Indena S.p.A., data on file.
6Magrone T.; Pugliese V.; Fontana S.; Jirillo E., Curr. Pharm. Des.
(2014) (in press)

phytosomes.info
indena.com,LEUCOSELECT® and PHYTOSOME® are• improve total antioxidant capacity ofplasma in healthy volunteers2• improve plasma oxidative status in healthy
volunteers after a fatty meal3• reduce LDL susceptibility to oxidative
stress in heavy smokers4• improve oxidative stress in humans with
impaired glucose homeostasis5• improve life conditions and immune
function in elderly people challenged byvarious conditions linked to the aging
processes6® TM

TRADEMARKS

trademarks of Indena S.p.A. © 2014, Indena S.p.A.

Recommended dose: 300 mg/day