SAFETY DATA SHEET
Invivoscribe® Gel Assays

Catalog Number

Descrip�on11000010

IGH + IGK B-Cell Clonality Assay for Gel Detec�on11010020

IGH Gene Clonality Assay for Gel Detec�on11020020

IGK Gene Clonality Assay for Gel Detec�on11030010

IGL Gene Clonality Assay for Gel Detec�on12050010

TCRB Gene Clonality Assay for Gel Detec�on12050020

TCRB Gene Clonality Assay MegaKit for Gel Detec�on12060010

TCRD Gene Clonality Assay for Gel Detec�on13080010

BCL1/JH Transloca�on Assay for Gel Detec�on13080020

BCL1/JH Transloca�on Assay MegaKit for Gel Detec�on13090010

BCL2/JH t(14;18) Transloca�on Assay for Gel Detec�on13090020

BCL2/JH Transloca�on Assay for Gel Detec�on13090040

BCL2/JH Transloca�on Assay MegaKit for Gel Detec�on13100010

BCR/ABL t(9;22) Transloca�on Assay for Gel Detec�on14120010

FLT3 Muta�on Assay for Gel Detec�on51010030

IGH Soma�c Hypermuta�on Assay v2.0 - Gel Detec�on51010040

IGH Soma�c Hypermuta�on Assay MegaKit v2.0 - Gel Detec�on

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SAFETY DATA SHEETThis safety data sheet was created pursuant to the requirements of:Regula�on (EC) No. 1907/2006 as amended by Commission Regula�on (EU)2020/878 and Regula�on (EC) No. 1272/2008
Issuing Date 27-Apr-2023

Revision Date 27-Apr-2023

Revision Number 1

SECTION 1: Iden�ﬁca�on of the substance/mixture and of the company/undertaking
1.1.

Product iden�ﬁer
Product Code(s)Product Name

Synonyms

40880190

IVS-0004 Clonal Control DNA

None

40880370

IVS-0007 Clonal Control DNA

None

40880430

IVS-0008 Clonal Control DNA

None

40880490

IVS-0009 Clonal Control DNA

None

40880550

IVS-0010 Clonal Control DNA

None

40880730

IVS-0013 Clonal Control DNA

None

40880970

IVS-0017 Clonal Control DNA

None

40881090

IVS-0019 Clonal Control DNA

None

40881210

IVS-0021 Clonal Control DNA

None

40881390

IVS-0024 Clonal Control DNA

None

40881690

IVS-0029 Clonal Control DNA

None

40881750

IVS-0030 Clonal Control DNA

None

40881810

IVS-0031 Clonal Control DNA

None

40890190

IVS-0003 Clonal Control RNA

None40890910

IVS-0011 Clonal Control RNA

None

40892800

IVS-0032 Clonal Control RNA

None

40893070

IVS-0035 Clonal Control RNA

None

40900010

IVS-P001 Clonal Control DNA

None

40900070

IVS-P002 Clonal Control DNA

None

40920010

IVS-0000 Polyclonal Control DNA

None

Pure substance/mixture

Mixture1.2.

Relevant iden�ﬁed uses of the substance or mixture and uses advised against
Recommended use
Assay reagent
Uses advised against
For professional use only

1.3.

Details of the supplier of the safety data sheet
Importer
Invivoscribe Technologies
Zeppelinstrasse 185399 Hallbergmoos
Germany
Phone: +49 89 904 299 800

Supplier
Invivoscribe, Inc.
10222 Barnes Canyon Rd
Bldg. 1San Diego, CA 92121
Phone: +1 858-224-6600

Distributor
Invivoscribe Technologies, SARL
c/o Ficorec Domicilia�on Services
132, Boulevard Michelet
Hall Nord – 5ème étage
13008 Marseille
FRANCE
Tel: +33 (0)4 42 01 78 10

For further informa�on, please contact
E-mail address
customerservice@invivoscribe.com
1.4.

Emergency telephone number

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Invivoscribe® Gel Assays

SECTION 1: Iden�ﬁca�on of the substance/mixture and of the company/undertaking
Emergency telephone+49 89 904 299 800 (M-F 8:00 – 16:30 CET)Emergency telephone - §45 - (EC)1272/2008
Europe112

SECTION 2: Hazards iden�ﬁca�on
2.1.

Classiﬁca�on of the substance or mixture
Classiﬁcation according to Regulation (EC) No. 1272/2008 [CLP]This substance is classiﬁed as not hazardous according to regula�on (EC) 1272/2008 [CLP].

2.2.

Label elements
Hazard statements
Not classiﬁed.
Unknown aqua�c toxicity

2.3.

Other hazards
No informa�on available.
Endocrine Disruptor
Informa�on

Contains 0 % of components with unknown hazards to the aqua�c environment.

This product does not contain any known or suspected endocrine disruptors.

SECTION 3: Composi�on/informa�on on ingredients
3.1

Substances
The product contains no substances which at their given concentra�on, are considered to be hazardous to health.
Full text of H- and EUH-phrases: see sec�on 16
Acute Toxicity Estimate
If LD50/LC50 data is not available or does not correspond to the classiﬁcation category, then the appropriate conversion value
from CLP Annex I, Table 3.1.2, is used to calculate the acute toxicity estimate (ATEmix) for classifying a mixture based on its
components
This product does not contain candidate substances of very high concern at a concentra�on >=0.1% (Regula�on (EC) No. 1907/2006(REACH), Ar�cle 59)

SECTION 4: First aid measures
4.1.

Descrip�on of ﬁrst aid measures
Inhala�on
Remove to fresh air. Get medical aten�on if symptoms occur.
Eye contact
Rinse thoroughly with plenty of water for at least 15 minutes, li�ing lower and upper eyelids.
Consult a physician.
Skin contact
Wash skin with soap and water. Get medical aten�on if symptoms occur.
Inges�on
Do NOT induce vomi�ng. Never give anything by mouth to an unconscious person. Rinse mouth.
Get medical aten�on if symptoms occur.

4.2.

Most important symptoms and eﬀects, both acute and delayed
Symptoms
None known.
Eﬀects of Exposure
No informa�on available.

4.3.

Indica�on of any immediate medical aten�on and special treatment needed
Note to physicians
Treat symptoma�cally.

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Invivoscribe® Gel Assays

SECTION 5: Fireﬁgh�ng measures
5.1.

Ex�nguishing media
Suitable Ex�nguishing MediaUse ex�nguishing measures that are appropriate to local circumstances and thesurrounding environment.
No informa�on available.

Unsuitable ex�nguishing media
5.2.

Special hazards arising from the substance or mixture
Speciﬁc hazards arising from the chemical
No informa�on available.

5.3.

Advice for ﬁreﬁghters
Special protec�ve equipment andprecau�ons for ﬁre-ﬁghters

Fireﬁghters should wear self-contained breathing apparatus and full ﬁreﬁgh�ng
turnout gear. Use personal protec�on equipment.

SECTION 6: Accidental release measures
6.1.

Personal precau�ons, protec�ve equipment and emergency procedures
Personal precau�ons
Ensure adequate ven�la�on.
For emergency responders
Use personal protec�on recommended in Sec�on 8.

6.2.

Environmental precau�ons
Environmental precau�ons

See Sec�on 12 for addi�onal Ecological Informa�on.

6.3.

Methods and material for containment and cleaning up
Methods for containment
Prevent further leakage or spillage if safe to do so.
Methods for cleaning up
Dam up. Soak up with inert absorbent material. Take up mechanically, placing in appropriate
containers for disposal.
Preven�on of secondary hazards
Clean contaminated objects and areas thoroughly observing environmental regula�ons.

6.4.

Reference to other sec�ons
Reference to other sec�ons

See sec�on 8 for more informa�on See sec�on 13 for more informa�on

SECTION 7: Handling and storage
7.1.

Precau�ons for safe handling
Advice on safe handling
General hygiene
considera�ons

Handle in accordance with good industrial hygiene and safety prac�ce.
Handle in accordance with good industrial hygiene and safety prac�ce.

7.2.

Condi�ons for safe storage, including any incompa�bili�esStorage Condi�ons
Keep containers �ghtly closed in a dry, cool and well-ven�lated place.
Storage class (TRGS 510)
Storage class 10.

7.3.

Speciﬁc end use(s)Speciﬁc use(s)The iden�ﬁed uses for this product are detailed in Sec�on 1.2.

SECTION 8: Exposure controls/personal protec�on
8.1.

Control parameters
Exposure Limits

This product, as supplied, does not contain any hazardous materials with occupa�onal exposure
limits established by the region speciﬁc regulatory bodies.

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Invivoscribe® Gel Assays

SECTION 8: Exposure controls/personal protec�onBiological occupa�onal exposure limits
This product, as supplied, does not contain any hazardous materials with biological limits established by the region-speciﬁc
regulatory bodies.
Derived No Eﬀect Level (DNEL) - Workers
No informa�on available.
Derived No Eﬀect Level (DNEL) - General Public
No informa�on available.
Predicted No Eﬀect Concentra�on (PNEC)
No informa�on available.
8.2.

Exposure controls
Engineering controls

Personal protec�ve equipment
Eye/face protec�on
Hand protec�on
Skin and body protec�on
Respiratory protec�onGeneral hygiene considera�ons
Environmental exposure controls

Showers
Eyewash sta�ons
Ven�la�on systems.

Wear safety glasses with side shields (or goggles). Eye protec�on must conform to standard
EN 166.
Wear suitable gloves. Gloves must conform to standard EN 374.
Wear suitable protec�ve clothing. (EN ISO 6529).
No protec�ve equipment is needed under normal use condi�ons. If exposure limits are
exceeded or irrita�on is experienced, ven�la�on and evacua�on may be required.
Handle in accordance with good industrial hygiene and safety prac�ce.
No informa�on available.

SECTION 9: Physical and chemical proper�es
9.1.

Informa�on on basic physical and chemical proper�es
Appearance
Physical state
LiquidColor
Colorless
Odor
Odorless
Odor thresholdNo informa�on available
PropertyMel�ng point / freezing pointIni�al boiling point and boiling range
Flammability
Flammability Limit in Air
Upper ﬂammability or explosive limits
Lower ﬂammability or explosive limits
Flash point
Autoigni�on temperature
Decomposi�on temperaturepH
pH (as aqueous solu�on)
Kinema�c viscosity
Dynamic viscosity
Water solubility
Solubility(ies)Par��on coeﬃcient
Vapor pressure
Rela�ve density
Bulk density
Liquid density

SDS – Invivoscribe Gel Assays (CLP)-EN Rev. A | January 2024

ValuesRemarks • Method
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
No data available
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Invivoscribe® Gel Assays

SECTION 9: Physical and chemical proper�esRela�ve vapor densityPar�cle characteris�cs
Par�cle sizePar�cle size distribu�on
9.2.

No data available
No data available
No data available
No data available

Other informa�on
9.2.1.
9.2.2.

Information with regard to physical hazard classes
Not applicable
Other safety characteristics
No informa�on available

SECTION 10: Stability and reac�vity
10.1. Reac�vity
Reac�vity

None under normal use condi�ons.

10.2. Chemical stability
Stability
Explosion data

Stable under normal condi�ons.

Sensi�vity to mechanical impact

None.

Sensi�vity to sta�c discharge

None.

10.3. Possibility of hazardous reac�ons
Possibility of hazardous reac�ons

None under normal processing.

10.4. Condi�ons to avoid
Condi�ons to avoid

None known based on informa�on supplied.

10.5. Incompa�ble materials
Incompa�ble materials

None known based on informa�on supplied.

10.6. Hazardous decomposi�on products
Hazardous decomposi�on products

None known based on informa�on supplied.

SECTION 11: Toxicological informa�on
11.1. Informa�on on hazard classes as deﬁned in Regula�on (EC) No 1272/2008
Informa�on on likely routes of exposure
Product Informa�on
Inhala�on
Speciﬁc test data for the substance or mixture is not available.
Eye contact

Speciﬁc test data for the substance or mixture is not available. Contact with eyes may cause irrita�on.

Skin contact

Speciﬁc test data for the substance or mixture is not available.

Inges�on

Speciﬁc test data for the substance or mixture is not available.

Symptoms related to the physical, chemical and toxicological characteris�cs
Symptoms
None known.
Acute toxicity
Numerical measures of toxicity
Based on available data, the classiﬁca�on criteria are not met.

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Invivoscribe® Gel Assays

SECTION 11: Toxicological informa�onComponent Informa�on
Delayed and immediate eﬀects as well as chronic eﬀects from short and long-term exposure
Skin corrosion/irrita�on
Based on available data, the classiﬁca�on criteria are not met.
Serious eye damage/eye irrita�on
Based on available data, the classiﬁca�on criteria are not met.
Respiratory or skin sensi�za�on
Based on available data, the classiﬁca�on criteria are not met.
Germ cell mutagenicity
Based on available data, the classiﬁca�on criteria are not met.
Carcinogenicity
Based on available data, the classiﬁca�on criteria are not met.
Reproduc�ve toxicity
Based on available data, the classiﬁca�on criteria are not met.
STOT - single exposure
Based on available data, the classiﬁca�on criteria are not met.
STOT - repeated exposure
Based on available data, the classiﬁca�on criteria are not met.
Aspira�on hazard
Based on available data, the classiﬁca�on criteria are not met.
11.2. Informa�on on other hazards
11.2.1.
Endocrine disrupting properties
Endocrine disrup�ng proper�es
11.2.2.
Other information
Other adverse eﬀects

This product does not contain any known or suspected endocrine disruptors.
No informa�on available.

SECTION 12: Ecological informa�on
12.1. Toxicity
Ecotoxicity
Unknown aqua�c toxicity

Based on available data, the classiﬁca�on criteria are not met. Based on available data, theclassiﬁca�on criteria are not met.
Contains 0 % of components with unknown hazards to the aqua�c environment.

12.2. Persistence and degradability
Persistence and degradability

No informa�on available.

12.3. Bioaccumula�ve poten�al
Bioaccumula�on

No informa�on available.

12.4. Mobility in soil
Mobility in soil

No informa�on available.

12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment
The product does not contain any substance(s) classiﬁed as PBT or vPvB.
12.6. Endocrine disrup�ng proper�es
Endocrine disrup�ng
proper�es
12.7. Other adverse eﬀects
Other adverse eﬀects

This product does not contain any known or suspected endocrine disruptors.

No informa�on available.

SECTION 13: Disposal considera�ons
13.1. Waste treatment methods

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Invivoscribe® Gel Assays

SECTION 13: Disposal considera�ons
Waste from residues/unused
products
Contaminated packaging
Waste codes / waste
designa�ons according to EWC/ AVV

Dispose of in accordance with local regula�ons. Dispose of waste in accordance withenvironmental legisla�on.
Do not reuse empty containers.
According to the European Waste Catalog, Waste Codes are not product speciﬁc, but applica�on
speciﬁc. Waste codes should be assigned by the user based on the applica�on for which the
product was used.

SECTION 14: Transport informa�on
IMDG
14.1
14.2
14.3
14.4
14.5
14.6

RID

ADR

IATA

Not regulated
UN number or ID number
UN proper shipping name
Transport hazard class(es)Packing group
Environmental hazards
Special Precau�ons for Users
Special Provisions

Not regulated
Not regulated
Not regulated
Not applicableNot applicable

14.7

Mari�me transport in bulk according
to IMO instruments

No informa�on available

14.1
14.2
14.3
14.4
14.5
14.6

UN numberUN proper shipping name
Transport hazard class(es)Packing group
Environmental hazards
Special Precau�ons for Users
Special Provisions

14.1
14.2
14.3
14.4
14.5
14.6

UN number or ID number
UN proper shipping name
Transport hazard class(es)Packing group
Environmental hazards
Special Precau�ons for Users
Special Provisions

14.1
14.2
14.3
14.4
14.5
14.6

UN number or ID number
UN proper shipping name
Transport hazard class(es)Packing group
Environmental hazards
Special Precau�ons for Users
Special Provisions
Note:

None

Not regulated
Not regulated
Not regulated
Not regulated
Not applicableNot applicableNone
Not regulated
Not regulated
Not regulated
Not regulated
Not applicableNot applicableNone
Not regulated
Not regulated
Not regulated
Not regulated
Not applicableNot applicable
None
None

SECTION 15: Regulatory informa�on
15.1. Safety, health and environmental regula�ons/legisla�on speciﬁc for the substance or mixture
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Invivoscribe® Gel Assays

SECTION 15: Regulatory informa�on
Na�onal regula�ons
Germany
Water hazard class (WGK)

non-hazardous to water (nwg)

European Union
Take note of Direc�ve 98/24/EC on the protec�on of the health and safety of workers from the risks related to chemical agents at
work.
Authoriza�ons and/or restric�ons on use:
This product does not contain substances subject to authoriza�on (Regula�on (EC) No. 1907/2006 (REACH), Annex XIV) This productdoes not contain substances subject to restric�on (Regula�on (EC) No. 1907/2006 (REACH), Annex XVII)Persistent Organic Pollutants
Not applicable
Ozone-deple�ng substances (ODS) regula�on (EC) 1005/2009
Not applicable
Interna�onal Inventories
Contact supplier for inventory compliance status
15.2. Chemical safety assessment
Chemical Safety Report

No informa�on available

SECTION 16: Other informa�on
Key or legend to abbrevia�ons and acronyms used in the safety data sheet
Legend
ATE: Acute Toxicity Es�mate
SVHC: Substances of Very High Concern for Authoriza�on:
PBT: Persistent, Bioaccumula�ve, and Toxic (PBT) Substances
vPvB: Very Persistent and very Bioaccumula�ve (vPvB) Substances
Legend Sec�on 8: Exposure controls/personal protec�on
TWA
TWA (�me-weighted average)
Ceiling
Maximum limit value
SCBA
Self-contained breathing apparatus
Classiﬁca�on procedure
Classiﬁca�on according to Regula�on (EC) No. 1272/2008 [CLP]
Acute oral toxicity
Acute dermal toxicity
Acute inhala�on toxicity - gas
Acute inhala�on toxicity - vapor
Acute inhala�on toxicity - dust/mist
Skin corrosion/irrita�on
Serious eye damage/eye irrita�on
Respiratory sensi�za�on
Skin sensi�za�on
Mutagenicity
Carcinogenicity
Reproduc�ve toxicity
STOT - single exposure
SDS – Invivoscribe Gel Assays (CLP)-EN Rev. A | January 2024

STEL*

STEL (Short Term Exposure Limit)
Skin designa�on

Method Used
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
On basis of test data
Calcula�on method
Calcula�on method
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Invivoscribe® Gel Assays

SECTION 16: Other informa�on
STOT - repeated exposure
Acute aqua�c toxicity
Chronic aqua�c toxicity
Aspira�on hazard
Ozone

Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method

Key literature references and sources for data used to compile the SDS
Agency for Toxic Substances and Disease Registry (ATSDR)
U.S. Environmental Protec�on Agency ChemView Database
European Food Safety Authority (EFSA)
European Chemicals Agency (ECHA) Commitee for Risk Assessment (ECHA_RAC)
European Chemicals Agency (ECHA) (ECHA_API)
EPA (Environmental Protec�on Agency)
Acute Exposure Guideline Level(s) (AEGL(s))
U.S. Environmental Protec�on Agency Federal Insec�cide, Fungicide, and Roden�cide Act
U.S. Environmental Protec�on Agency High Produc�on Volume Chemicals
Food Research Journal
Hazardous Substance Database
Interna�onal Uniform Chemical Informa�on Database (IUCLID)
Japan GHS Classiﬁca�onAustralia Na�onal Industrial Chemicals No�ﬁca�on and Assessment Scheme (NICNAS)
NIOSH (Na�onal Ins�tute for Occupa�onal Safety and Health)Na�onal Library of Medicine's ChemID Plus (NLM CIP)
Na�onal Library of Medicine’s PubMed database (NLM PUBMED)
United States of America Na�onal Toxicology Program (NTP)New Zealand's Chemical Classiﬁca�on and Informa�on Database (CCID)
Organiza�on for Economic Co-opera�on and Development Environment, Health, and Safety Publica�ons
Organiza�on for Economic Co-opera�on and Development High Produc�on Volume Chemicals Program
Organiza�on for Economic Co-opera�on and Development Screening Informa�on Data Set
World Health Organiza�on
Issuing Date
Revision Date
Revision Note

27-Apr-2023
27-Apr-2023
Ini�al Release.

This safety data sheet complies with the requirements of Commission Regula�on (EU) 2020/878 of 18 June 2020 amending Regula�on(EC) No. 1907/2006
Disclaimer
The informa�on provided in this Safety Data Sheet is correct to the best of our knowledge, informa�on and belief at the date of its
publica�on. The informa�on given is designed only as a guidance for safe handling, use, processing, storage, transporta�on, disposal
and release and is not to be considered a warranty or quality speciﬁca�on. The informa�on relates only to the speciﬁc material
designated and may not be valid for such material used in combina�on with any other materials or in any process, unless speciﬁed in
the text.

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SAFETY DATA SHEETThis safety data sheet was created pursuant to the requirements of:Regula�on (EC) No. 1907/2006 as amended by Commission Regula�on (EU)2020/878 and Regula�on (EC) No. 1272/2008
Issuing Date 27-Apr-2023

Revision Date 27-Apr-2023

Revision Number 1

SECTION 1: Iden�ﬁca�on of the substance/mixture and of the company/undertaking
1.1.

Product iden�ﬁer
Product Code(s)20960010
20960020
21010010
21010020
21010030
21010040
21010050
21010170
21010180
21020010
21020020
21030010
22050010
22050020
22050030
22060010
23080010
23090010
23090020
23090030
23090040
23090050
23090060
23090070
23100010
23100020
23100030
23100040
23100050
23100060
23100070
23100080
23100090
24120010
24120020
30000000
31010380
Pure substance/mixture

1.2.

Product Name
Ampliﬁca�on Control - Unlabeled for Gel Detec�onSpecimen Control Size Ladder - Unlabeled for Gel Detec�on
IGH Tube A - Unlabeled for Gel Detec�on
IGH Tube B - Unlabeled for Gel Detec�on
IGH Tube C - Unlabeled for Gel Detec�on
IGH Tube D - Unlabeled for Gel Detec�on
IGH Tube E - Unlabeled for Gel Detec�onHypermuta�on Mix 1 v2.0 - Unlabeled for Gel Detec�onHypermuta�on Mix 2 v2.0 Unlabeled for Gel Detec�on
IGK Tube A - Unlabeled for Gel Detec�on
IGK Tube B - Unlabeled for Gel Detec�on
IGL Tube - Unlabeled for Gel Detec�on
TCRB Tube A - Unlabeled for Gel Detec�on
TCRB Tube B - Unlabeled for Gel Detec�on
TCRB Tube C - Unlabeled for Gel Detec�on
TCRD Tube - Unlabeled for Gel Detec�on
BCL1/JH Tube - Unlabeled for Gel Detec�on
BCL2/JH t(14;18) (Mbr) Mix 1b - Unlabeled for Gel Detec�on
BCL2/JH t(14;18) (mcr) Mix 2b - Unlabeled for Gel Detec�on
BCL2/JH t(14;18) (Mbr) Mix 1a - Unlabeled for Gel Detec�on
BCL2/JH t(14;18) (mcr) Mix 2a - Unlabeled for Gel Detec�on
BCL2/JH Tube A - Unlabeled for Gel Detec�on
BCL2/JH Tube B - Unlabeled for Gel Detec�on
BCL2/JH Tube C - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 1a - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 2a - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 3a - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 1b - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 2b - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 2c - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 3b - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 3c - Unlabeled for Gel Detec�on
BCR/ABL t(9;22) Mix 3d - Unlabeled for Gel Detec�on
FLT3 ITD Master Mix for Gel Detec�on
FLT3 D835 Master Mix for Gel Detec�onPrimer Hypermuta�on 100 μM - Unlabeled
IGH JH Primer 100 μM - Unlabeled

Synonyms
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None
None

MixtureRelevant iden�ﬁed uses of the substance or mixture and uses advised against

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SECTION 1: Iden�ﬁca�on of the substance/mixture and of the company/undertaking
Recommended use
Uses advised against
1.3.

Assay reagent
For professional use only

Details of the supplier of the safety data sheet
Importer
Invivoscribe Technologies
Zeppelinstrasse 185399 Hallbergmoos
Germany
Phone: +49 89 904 299 800

1.4.

Supplier
Invivoscribe, Inc.
10222 Barnes Canyon Rd
Bldg. 1San Diego, CA 92121
Phone: +1 858-224-6600

Distributor
Invivoscribe Technologies, SARL
c/o Ficorec Domicilia�on Services
132, Boulevard Michelet
Hall Nord – 5ème étage
13008 Marseille
FRANCE
Tel: +33 (0)4 42 01 78 10

For further informa�on, please contact
E-mail address

customerservice@invivoscribe.com

Emergency telephone number
Emergency telephone+49 89 904 299 800 (M-F 8:00 – 16:30 CET)Emergency telephone - §45 - (EC)1272/2008
Europe112

SECTION 2: Hazards iden�ﬁca�on
2.1.

Classiﬁca�on of the substance or mixture
Classiﬁcation according to Regulation (EC) No. 1272/2008 [CLP]This mixture is classiﬁed as not hazardous according to regula�on (EC) 1272/2008 [CLP]

2.2.

Label elements
Hazard statements

2.3.

Not classiﬁed.
Unknown aqua�c toxicity

Contains 0 % of components with unknown hazards to the aqua�c environment.

Other hazards
Endocrine Disruptor Informa�on

This product does not contain any known or suspected endocrine disruptors.

SECTION 3: Composi�on/informa�on on ingredients
3.1

Substances
Not applicable

3.2

Mixtures
Chemical name

Weight%REACH
registra�onnumberEC No (EU
Index No)Classiﬁca�onaccording toRegula�on (EC) No.
1272/2008 [CLP][C]

Speciﬁcconcentra�onlimit (SCL)

MFactor

M-Factor(long-term)

Dimethyl sulfoxide
1-5
No data
200-664-3
67-68-5
available
Classiﬁcation according to Regulation (EC) No. 1272/2008 [CLP] - Notes[C] - Components with occupational exposure limits and/or biological occupational exposure limits requiring monitoring

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SECTION 3: Composi�on/informa�on on ingredients
Full text of H- and EUH-phrases: see sec�on 16
Acute Toxicity Estimate
If LD50/LC50 data is not available or does not correspond to the classiﬁcation category, then the appropriate conversion value
from CLP Annex I, Table 3.1.2, is used to calculate the acute toxicity estimate (ATEmix) for classifying a mixture based on its
components
Chemical name
Oral LD50 mg/kg
Dermal LD50
Inhala�on LC50 - 4
Inhala�on LC50 - 4 Inhala�on LC50 - 4
mg/kg
hour - dust/mist hour - vapor hour - gas - ppm
mg/L
mg/L
Dimethyl sulfoxide
28300
40000
5.3353No data available
No data available
67-68-5This product does not contain candidate substances of very high concern at a concentra�on >=0.1% (Regula�on (EC) No. 1907/2006(REACH), Ar�cle 59)

SECTION 4: First aid measures
4.1.

Descrip�on of ﬁrst aid measures
Inhala�on
Remove to fresh air. Get medical aten�on if symptoms occur.
Eye contact
Rinse thoroughly with plenty of water, also under the eyelids. Get medical aten�on if symptoms occur.
Skin contact
Wash skin with soap and water. Get medical aten�on if symptoms occur.
Inges�on
Do NOT induce vomi�ng. Never give anything by mouth to an unconscious person. Rinse mouth. Get medicalaten�on if symptoms occur.

4.2.

Most important symptoms and eﬀects, both acute and delayed
Symptoms
None known.
Eﬀects of Exposure
No informa�on available.

4.3.

Indica�on of any immediate medical aten�on and special treatment needed
Note to physicians
Treat symptoma�cally.

SECTION 5: Fireﬁgh�ng measures
5.1.

Ex�nguishing media
Suitable Ex�nguishing MediaUse ex�nguishing measures that are appropriate to local circumstances and thesurrounding environment.
No informa�on available.

Unsuitable ex�nguishing media
5.2.

Special hazards arising from the substance or mixture
Speciﬁc hazards arising from the chemical
No informa�on available.

5.3.

Advice for ﬁreﬁghters
Special protec�ve equipment andprecau�ons for ﬁre-ﬁghters

Fireﬁghters should wear self-contained breathing apparatus and full ﬁreﬁgh�ng
turnout gear. Use personal protec�on equipment.

SECTION 6: Accidental release measures
6.1.

Personal precau�ons, protec�ve equipment and emergency procedures
Personal precau�ons
Ensure adequate ven�la�on.
For emergency responders
Use personal protec�on recommended in Sec�on 8.

6.2.

Environmental precau�ons
Environmental precau�ons

See Sec�on 12 for addi�onal Ecological Informa�on.

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SECTION 6: Accidental release measures
6.3.

Methods and material for containment and cleaning up
Methods for containment
Prevent further leakage or spillage if safe to do so.
Methods for cleaning up
Dam up. Soak up with inert absorbent material. Take up mechanically, placing inappropriate containers for disposal.
Preven�on of secondary hazards
Clean contaminated objects and areas thoroughly observing environmental regula�ons.

6.4.

Reference to other sec�ons
Reference to other sec�ons

See sec�on 8 for more informa�on See sec�on 13 for more informa�on

SECTION 7: Handling and storage
7.1.

Precau�ons for safe handling
Advice on safe handling
General hygiene considera�ons

7.2.

Condi�ons for safe storage, including any incompa�bili�esStorage Condi�ons
Keep containers �ghtly closed in a dry, cool and well-ven�lated place.
Storage class (TRGS 510)
Storage class 10.

7.3.

Speciﬁc end use(s)Speciﬁc use(s)Handle in accordance with good industrial hygiene and safety prac�ce.
Handle in accordance with good industrial hygiene and safety prac�ce.

The iden�ﬁed uses for this product are detailed in Sec�on 1.2.

SECTION 8: Exposure controls/personal protec�on
8.1.

Control parameters
Exposure Limits
Chemical name
Dimethyl sulfoxide
67-68-5

European Union-

Austria
TWA: 50 ppm
TWA: 160 mg/m3
H*
Czech Republic-

Belgium-

Bulgaria-

Croa�a-Denmark
TWA: 50 ppm
TWA: 160 mg/m3
STEL: 100 ppm
STEL: 320 mg/m3

Estonia
TWA: 50 ppm
TWA: 150 mg/m3
STEL: 150 ppm
STEL: 500 mg/m3
A*
Greece-Finland
TWA: 50 ppm
iho*

Latvia-Lithuania
O*
TWA: 50 ppm
TWA: 150 mg/m3
STEL: 150 ppm
STEL: 500 mg/m3
Spain-

Chemical name
Dimethyl sulfoxide
67-68-5

Cyprus-Chemical name
Dimethyl sulfoxide
67-68-5

France-Germany TRGS
TWA: 50 ppm
TWA: 160 mg/m3
H*

Chemical name
Dimethyl sulfoxide
67-68-5

Ireland-

Italy MDLPS-

Germany DFG
TWA: 50 ppm
TWA: 160 mg/m3
Peak: 100 ppm
Peak: 320 mg/m3*
Italy AIDII-

Chemical name
Dimethyl sulfoxide
67-68-5

Portugal-

Romania-

Slovakia-

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Slovenia
TWA: 160 mg/m3
TWA: 50 ppm

Hungary-

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SECTION 8: Exposure controls/personal protec�on

Chemical name
Dimethyl sulfoxide
67-68-5

SwedenNGV: 50 ppm
NGV: 150 mg/m3
Vägledande KGV: 150 ppm
Vägledande KGV: 500 mg/m3
H*

Switzerland
TWA: 50 ppm
TWA: 160 mg/m3
STEL: 100 ppm
STEL: 320 mg/m3
H*

STEL: 100 ppm
STEL: 320 mg/m3
K*
United Kingdom-

Biological occupa�onal exposure limits
This product, as supplied, does not contain any hazardous materials with biological limits established by the region speciﬁc
regulatory bodies.
Derived No Eﬀect Level (DNEL) - Workers
Chemical name
Dimethyl sulfoxide
67-68-5
Notes
[4]
[5]
[6]
[7]
Derived No Eﬀect Level (DNEL) - General Public
Chemical name
Dimethyl sulfoxide
67-68-5
Notes
[4]
[5]
[6]
[7]
Predicted No Eﬀect Concentra�on (PNEC)
Chemical nameFreshwater

Dimethyl sulfoxide
67-68-5

17 mg/L

Chemical nameFreshwater
sediment
13.4 mg/kg
sediment dw

Dimethyl sulfoxide
67-68-5
8.2.

Exposure controls
Engineering controls

Oral-

Dermal200 mg/kg bw/day [4] [6]Inhala�on
484 mg/m3 [4] [6]265 mg/m3 [5] [6]

Systemic health eﬀects.
Local health eﬀects.
Long term.
Short term.

Oral
60 mg/kg
bw/day [4] [6]Dermal-Inhala�on
120 mg/m3 [4] [6]47 mg/m3 [5] [6]

Systemic health eﬀects.
Local health eﬀects.
Long term.
Short term.

Freshwater(intermitent
release)-Marine waterAir

1.7 mg/L

Marine water(intermitent
release)-Marine sediment

Sewage treatment

Soil

Food chain-

11 mg/L

3.02 mg/kg soil dw

0.7 g/kg food-Showers
Eyewash sta�ons
Ven�la�on systems.

Personal protec�ve equipment
Eye/face protec�on

Wear safety glasses with side shields (or goggles). Eye protec�on must conform tostandard EN 166.

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SECTION 8: Exposure controls/personal protec�on
Hand protec�on
Skin and body protec�on
Respiratory protec�on

Wear suitable gloves. Gloves must conform to standard EN 374.
Wear suitable protec�ve clothing (EN ISO 6529).
No protec�ve equipment is needed under normal use condi�ons. If exposure
limits are exceeded or irrita�on is experienced, ven�la�on and evacua�on may berequired.
Handle in accordance with good industrial hygiene and safety prac�ce.
No informa�on available.

General hygiene considera�ons
Environmental exposure controls

SECTION 9: Physical and chemical proper�es
9.1.

Informa�on on basic physical and chemical proper�es
Appearance
Clear liquid
Physical state
LiquidColor
Colorless. Light blue, light yellow, light pink. or light orange
Odor
Odorless
Odor thresholdNo informa�on available
PropertyMel�ng point / freezing point

ValuesRemarks • Method
No data available

Ini�al boiling point and boiling range

No data available

Flammability

No data available

Flammability Limit in Air
Upper ﬂammability or explosive limits

No data available

Lower ﬂammability or explosive limits

No data available

Flash point

No data available

Autoigni�on temperature

No data available

Decomposi�on temperaturepH
pH (as aqueous solu�on)

No data available
7

-

9.5

Kinema�c viscosity

No data available

Dynamic viscosity

No data available

Water solubility
Solubility(ies)

No data available
No data available

Par��on coeﬃcient

No data available

Vapor pressure

No data available

Rela�ve density

No data available

Bulk density

No data available

Liquid Density

No data available

Rela�ve vapor density

No data availablePar�cle characteris�cs
Par�cle Size

No data availablePar�cle Size Distribu�on
9.2.

No data available
No data available

No data available

Other informa�on
9.2.1.
9.2.2.

Information with regard to physical hazard classes
Not applicable
Other safety characteristics
No informa�on available

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SECTION 10: Stability and reac�vity
10.1. Reac�vity
Reac�vity

None under normal use condi�ons.

10.2. Chemical stability
Stability
Explosion data

Stable under normal condi�ons.

Sensi�vity to mechanical impact

None.

Sensi�vity to sta�c discharge

None.

10.3. Possibility of hazardous reac�ons
Possibility of hazardous reac�ons

None under normal processing.

10.4. Condi�ons to avoid
Condi�ons to avoid

None known based on informa�on supplied.

10.5. Incompa�ble materials
Incompa�ble materials

None known based on informa�on supplied.

10.6. Hazardous decomposi�on products
Hazardous decomposi�on products

None known based on informa�on supplied.

SECTION 11: Toxicological informa�on
11.1. Informa�on on hazard classes as deﬁned in Regula�on (EC) No 1272/2008
Informa�on on likely routes of exposure
Product Informa�on
Inhala�on

Speciﬁc test data for the substance or mixture is not available.

Eye contact

Speciﬁc test data for the substance or mixture is not available. Contact with eyes may cause irrita�on.

Skin contact

Speciﬁc test data for the substance or mixture is not available.

Inges�on

Speciﬁc test data for the substance or mixture is not available.

Symptoms related to the physical, chemical and toxicological characteris�cs
Symptoms
None known.
Acute toxicity
Numerical measures of toxicity
Based on available data, the classiﬁca�on criteria are not met.
Component Informa�on
Chemical name
Dimethyl sulfoxide

Oral LD50= 28300 mg/kg( Rat )

Dermal LD50
= 40000 mg/kg ( Rat )Inhala�on LC50
> 5.33 mg/L ( Rat ) 4 h

Delayed and immediate eﬀects as well as chronic eﬀects from short and long-term exposure
Skin corrosion/irrita�on
Based on available data, the classiﬁca�on criteria are not met.
Serious eye damage/eye irrita�on
Based on available data, the classiﬁca�on criteria are not met.
Respiratory or skin sensi�za�on
Based on available data, the classiﬁca�on criteria are not met.
Germ cell mutagenicity
Based on available data, the classiﬁca�on criteria are not met.
Carcinogenicity
Based on available data, the classiﬁca�on criteria are not met.
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SECTION 11: Toxicological informa�on
Reproduc�ve toxicity
STOT - single exposure
STOT - repeated exposure
Aspira�on hazard

Based on available data, the classiﬁca�on criteria are not met.
Based on available data, the classiﬁca�on criteria are not met.
Based on available data, the classiﬁca�on criteria are not met.
Based on available data, the classiﬁca�on criteria are not met.

11.2. Informa�on on other hazards
11.2.1.
Endocrine disrupting properties
Endocrine disrup�ng proper�es
11.2.2.
Other information
Other adverse eﬀects

This product does not contain any known or suspected endocrine disruptors.
No informa�on available.

SECTION 12: Ecological informa�on
12.1. Toxicity
Ecotoxicity
Unknown aqua�c toxicity
Chemical name
Dimethyl sulfoxide
67-68-5

Based on available data, the classiﬁca�on criteria are not met. Based on available data, theclassiﬁca�on criteria are not met.
Contains 0 % of components with unknown hazards to the aqua�c environment.

Algae/aqua�cplants
-12.2. Persistence and degradability
Persistence and degradability

Fish
LC50: =34000mg/L (96h, Pimephales promelas)
LC50: 33 - 37g/L (96h, Oncorhynchus mykiss)
LC50: >40g/L (96h, Lepomis macrochirus)
LC50: =41.7g/L (96h, Cyprinus carpio)

Toxicity to
microorganisms-

Crustacea-

No informa�on available.

12.3. Bioaccumula�ve poten�al
Bioaccumula�onComponent Informa�on
Chemical name
Dimethyl sulfoxide
12.4. Mobility in soil
Mobility in soilPar��on coeﬃcient-1.35

No informa�on available.

12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment
The product does not contain any substance(s) classiﬁed as PBT or vPvB.
Chemical name
Dimethyl sulfoxide
67-68-5

PBT and vPvB assessment
The substance is not PBT / vPvB

12.6. Endocrine disrup�ng proper�es
Endocrine disrup�ng proper�esThis product does not contain any known or suspected endocrine disruptors.

12.7. Other adverse eﬀects
Other adverse eﬀects

No informa�on available.

SECTION 13: Disposal considera�ons
13.1. Waste treatment methods
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SECTION 13: Disposal considera�ons
Waste from residues/unused productsContaminated packaging
Waste codes / waste designa�ons
according to EWC / AVV

Dispose of in accordance with local regula�ons. Dispose of waste in accordance withenvironmental legisla�on.
Do not reuse empty containers.
According to the European Waste Catalog, Waste Codes are not product speciﬁc, but
applica�on speciﬁc. Waste codes should be assigned by the user based on theapplica�on for which the product was used.

SECTION 14: Transport informa�on
IMDG
14.1
14.2
14.3
14.4
14.5
14.6
14.7
RID

Not regulated
Not regulated
Not regulated
Not regulated
Not applicableNot applicable

UN number or ID number
UN proper shipping name
Transport hazard class(es)Packing group
Environmental hazards
Special Precau�ons for Users
Special Provisions

None

Mari�me transport in bulk according
to IMO instruments

Not regulated
Not regulated
Not regulated
Not regulated
Not applicableNot applicable

14.1 UN number
14.2 UN proper shipping name14.3 Transport hazard class(es)14.4 Packing group
14.5 Environmental hazards
14.6 Special Precau�ons for Users
Special Provisions

ADR

14.1
14.2
14.3
14.4
14.5
14.6

IATA
14.1
14.2
14.3
14.4
14.5
14.6
Note:

No informa�on available

None
Not regulated
Not regulated
Not regulated
Not regulated
Not applicableNot applicable

UN number or ID number
UN proper shipping name
Transport hazard class(es)Packing group
Environmental hazards
Special Precau�ons for Users
Special Provisions

None
Not regulated
Not regulated
Not regulated
Not regulated
Not applicableNot applicable

UN number or ID number
UN proper shipping name
Transport hazard class(es)Packing group
Environmental hazards
Special Precau�ons for Users
Special Provisions

None
None

SECTION 15: Regulatory informa�on
15.1. Safety, health and environmental regula�ons/legisla�on speciﬁc for the substance or mixture
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SECTION 15: Regulatory informa�on
Na�onal regula�ons
FranceOccupa�onal Illnesses (R-463-3, France)
Chemical name
Dimethyl sulfoxide
67-68-5
Germany
Water hazard class (WGK)

French RG number
RG 84

non-hazardous to water (nwg)

European Union
Take note of Direc�ve 98/24/EC on the protec�on of the health and safety of workers from the risks related to chemical agents at
work.
Authoriza�ons and/or restric�ons on use:
This product contains one or more substance(s) subject to restric�on (Regula�on (EC) No. 1907/2006 (REACH), Annex XVII)
Chemical nameRestricted substance per REACH
Substance subject to authoriza�on per
Annex XVIIREACH Annex XIV
Dimethyl sulfoxide - 67-68-5
75.
Persistent Organic Pollutants
Not applicable
Ozone-deple�ng substances (ODS) regula�on (EC) 1005/2009
Not applicable
Interna�onal Inventories
Contact supplier for inventory compliance status
15.2. Chemical safety assessment
Chemical Safety Report

No informa�on available

SECTION 16: Other informa�on
Key or legend to abbrevia�ons and acronyms used in the safety data sheet
Legend
ATE: Acute Toxicity Es�mate
SVHC: Substances of Very High Concern for Authoriza�on:
PBT: Persistent, Bioaccumula�ve, and Toxic (PBT) Substances
vPvB: Very Persistent and very Bioaccumula�ve (vPvB) Substances
Legend Sec�on 8: Exposure controls/personal protec�on
TWA
TWA (�me-weighted average)
Ceiling
Maximum limit value
SCBA
Self-contained breathing apparatus
Classiﬁca�on procedure
Classiﬁca�on according to Regula�on (EC) No. 1272/2008 [CLP]
Acute oral toxicity
Acute dermal toxicity
Acute inhala�on toxicity - gas

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STEL*

STEL (Short Term Exposure Limit)
Skin designa�on

Method Used
Calcula�on method
Calcula�on method
Calcula�on method

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SECTION 16: Other informa�on
Acute inhala�on toxicity - vapor
Acute inhala�on toxicity - dust/mist
Skin corrosion/irrita�on
Serious eye damage/eye irrita�on
Respiratory sensi�za�on
Skin sensi�za�on
Mutagenicity
Carcinogenicity
Reproduc�ve toxicity
STOT - single exposure
STOT - repeated exposure
Acute aqua�c toxicity
Chronic aqua�c toxicity
Aspira�on hazard
Ozone

Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
On basis of test data
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method
Calcula�on method

Key literature references and sources for data used to compile the SDS
Agency for Toxic Substances and Disease Registry (ATSDR)
U.S. Environmental Protec�on Agency ChemView Database
European Food Safety Authority (EFSA)
European Chemicals Agency (ECHA) Commitee for Risk Assessment (ECHA_RAC)
European Chemicals Agency (ECHA) (ECHA_API)
EPA (Environmental Protec�on Agency)
Acute Exposure Guideline Level(s) (AEGL(s))
U.S. Environmental Protec�on Agency Federal Insec�cide, Fungicide, and Roden�cide Act
U.S. Environmental Protec�on Agency High Produc�on Volume Chemicals
Food Research Journal
Hazardous Substance Database
Interna�onal Uniform Chemical Informa�on Database (IUCLID)
Japan GHS Classiﬁca�onAustralia Na�onal Industrial Chemicals No�ﬁca�on and Assessment Scheme (NICNAS)
NIOSH (Na�onal Ins�tute for Occupa�onal Safety and Health)Na�onal Library of Medicine's ChemID Plus (NLM CIP)
Na�onal Library of Medicine’s PubMed database (NLM PUBMED)
United States of America Na�onal Toxicology Program (NTP)New Zealand's Chemical Classiﬁca�on and Informa�on Database (CCID)
Organiza�on for Economic Co-opera�on and Development Environment, Health, and Safety Publica�ons
Organiza�on for Economic Co-opera�on and Development High Produc�on Volume Chemicals Program
Organiza�on for Economic Co-opera�on and Development Screening Informa�on Data Set
World Health Organiza�on
Issuing Date

27-Apr-2023

Revision Date

27-Apr-2023

Revision Note

Ini�al Release.

This safety data sheet complies with the requirements of Commission Regula�on (EU) 2020/878 of 18 June 2020 amending Regula�on(EC) No. 1907/2006
Disclaimer
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SECTION 16: Other informa�on
The informa�on provided in this Safety Data Sheet is correct to the best of our knowledge, informa�on and belief at the date of its
publica�on. The informa�on given is designed only as a guidance for safe handling, use, processing, storage, transporta�on, disposal
and release and is not to be considered a warranty or quality speciﬁca�on. The informa�on relates only to the speciﬁc material
designated and may not be valid for such material used in combina�on with any other materials or in any process, unless speciﬁed in
the text.
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