Last day to submit your abstract May 18th.
Oxygen Club of California World Congress, Alba, Italy, June 20-23, 2012
The 2012 OCC Oxidants and Antioxidants in Biology congress will focus on Cell Signaling andNutrient-Gene Interactions. In keeping with our tradition, a unique cadre of scientists will present
cutting-edge program covering transcriptional regulation of antioxidant defenses, the interaction ofnutrients with genes and epigenetics, novel roles of micronutrients with emphasis on flavonoids and theMediterranean diet, lipid oxidation and signaling, and the role of epigenetics and metabolism in aging (seebelow speakers and themes).
The scientific atmosphere will be complimented by poster viewing in the San Domenico church, a XIV thcentury gothic monument. A medley of famous opera arias will be performed in the Teatro Sociale, animpressive XIXth century building. At the Gala Dinner, awards and prizes will be presented to young
investigators and distinguished scholars: the Science and Humanity Award, Aging Research Award, and theHealth Sciences Prize.
Please visit the Congress website for complete information.
Conference Organizers: GIUSEPPE POLI & MARET TRABER
Honorary President: LESTER PACKER

Speakers and Topics
Keynote Lecture
Richard Weindruch

Metabolic reprogramming, caloric restriction, and aging

I – NRF2-Driven Regulation of Antioxidant Defenses
Masayuki Yamamoto

Molecular mechanisms of Keap1-Nrf2 pathway in stress response and cancerevolution

Thomas Kensler

Keap1-Nrf2 signaling: targets for disease prevention

Giovanni Mann

Nrf2-mediated redox signaling in endothelial cells: consequences for
cardiovascular disease

Young-Joon Surh

Adaptive survival response mediated by the Nrf2-induced HO1 upregulation

Regina Brigelius-FlohéNrf2 target genes are induced under marginal selenium deficiency

II – Nutrient-Gene Interactions and Epigenetics
Ben van Ommen

Micronutrient genomics: an overview

Steven Zeisel

Functional genetic polymorphisms in genes of choline metabolism

Frederick E. Domann

The redox basis of epigenetic control

Emily Ho

Dietary histone deacetylase inhibitors for cancer prevention

Bharat B. Aggarwal

Epigenetic changes induced by curcumin

Irfan Rahman

Redox epigenetic modifications by dietary bioactive compounds ininflammation

III – Novel Roles of Micronutrients
Vittorio CalabreseRedox regulation of cellular stress response in aging and neurodegenerative
disorders: role of hormesis and vitagens

Helen McNulty

MTHFR genotype and riboflavin: a novel gene-nutrient interaction affecting
blood pressure

David Heber

Biomedical action of pomegranate ellagitannins

Louis Casteilla

Redox metabolism, coenzyme Q, and obesity

David Carlson

Redox modulation of cell signaling by lipoic acid and derivatives. Simultaneous
analysis of the effects of chirality and neutral versus charged amide substitution
in forty-five pathways

Andrew Levy

Pharmacogenomic interactions between vitamin E and the haptoglobin genotype
in the prevention of diabetic vascular disease

Patricia Oteiza

Zinc and redox signaling in the developing brain

IV – Lipid Oxidation and Signaling
Etsuo Niki

Physiological and unregulated membrane lipid oxidation

Laszlo Nagy

Transcriptional interactions involving hormone nuclear receptors shaping
macrophage polarity and activity

Gabriella Leonarduzzi

Lipid oxidation-mediated mechanisms of destabilization of the atherosclerotic
plaqueLuigi Iuliano

Oxysterols in the pathogenesis of inflammatory-based disease

Francisco Schopfer

Electrophilic nitro-fatty acids as anti-inflammatory mediators in the vascularcompartment

Oren Tirosh

High cholesterol diet-induced impairment of glucose homeostasis in mice withfatty liver: role of inducible NOS

Gaetano Serviddio

Non-alcoholic fatty liver disease, oxidative stress, and mitochondria

Corinne M. Spickett

Lipid-protein adducts as biomarkers of inflammatory-based diseases in humans

Tilman Grune

Lipid protein interactions in cell signaling and toxicity

V – Epigenetics, Metabolism, and Aging
Mario Fraga

Epigenetic regulation of aging

Gregory Brewer

Epigenetic redox shift, nutrients, aging, and insulinSilvia Gravina

Role of random changes to epigenetic marks in aging

Ana Maria Cuervo

Autophagy and aging

José Viña

Modulation of aging genes: importance in longevity and age-associated frailty

Matthew O’Connor

Relocation of mtDNA to the nucleus: implications for mitochondrial mutations

Suresh Rattan

Molecular gerontology: from molecules to hormesis

Kelvin J. A. Davies

Proteolytic signaling dysfunction in aging

Malcolm Jackson

Reactive oxygen species in muscle wasting during aging

Leo Rodriguez-Mañas

Frailty: a basic and clinical challenge for the future

Maria Cristina Polidori

Oxidative stress and the link of pathophysiology of Alzheimer's disease with
vascular pathology