The 14th International Symposium of the Institute Network for Biomedical Sciences

Frontier in Medical Science and Microbial Diseases
Research Institute for Microbial Diseases, Osaka University

October 2 - 3, 2019
Hankyu Corporation-Sanwa Bank Hall, Icho-Kaikan, Osaka University, Osaka, Japan

Wednesday, October 2, 201909:20 -Registration

10:00 - 10:05

Opening Remarks
Yoshiharu Matsuura (Director of Research Institute for Microbial Diseases,Osaka University)

Session 1:

Advanced Technologies in Medical Science

Chairs:Daron M. Standley (Research Institute for Microbial Diseases/ Immunology Frontier Research Center,Osaka University)
Kenji Mizuguchi (Institute for Protein Research, Osaka University)

10:05-10:30

S-01: Ken J. Ishii (The Institute of Medical Science, The University ofTokyo)
Application of Machine Learning to Vaccine Adjuvants: Deep Learning
versus Classic Immunology

10:30-10:55

S-02: Yasuyuki Taki (Institute of Development, Aging and Cancer, Tohoku
University)
Brain development and aging using large brain MRI database

10:55-11:20

S-03: Kenji Mizuguchi (Institute for Protein Research, Osaka University)
Data integration as a basis for artificial intelligence in drug discovery

11:20-11:35

Coffee Break

11:35-11:50

Y-01(P-01): Daisuke Kamimura (Institute for Genetic Medicine, HokkaidoUniversity)
Characterization of the Gateway Reflex in space by the world's first diseasemodel experiment in ISS

11:50-12:05

Y-02(P-05): Yoh Matsuki (Institute for Protein Research, Osaka University)
Hybrid Structural Analysis of 𝛽2-Microglobulin Amyloid Fibril fromAmyloidosis Patient using Solid-State NMR and Cryo-EM

12:05-12:20

Group Photo at 1F Entrance Hall

12:20-13:50

Luncheon Poster Session at 3F Main conference room
(Complimentary light meal and soft drinks)

Keynote Lecture
Chair:

Sho Yamasaki (Research Institute for Microbial Diseases/ Immunology Frontier Research Center, OsakaUniversity)

13:50-14:30

Andre Veillette (University of Montréal and McGill University, Canada)
Innate immune cells in normal and anti-tumor immunity
614:30-14:50

Coffee BreakSession 2:

Novel in vivo approaches in Medical Science

Chairs:Masahito Ikawa (Research Institute for Microbial Diseases, Osaka University)
Junji Takeda (Research Institute for Microbial Diseases, Osaka University)

14:50-15:15

S-04: Kosuke Yusa (Institute for Frontier Life and Medical Sciences, Kyoto
University)
Development and application of genome-wide CRISPR-KO screening

15:15-15:40

S-05: Masahiro Sonoshita (Institute for Genetic Medicine, Hokkaido
University)
A whole animal platform for discovering novel anti-cancer drugs

15:40-15:55

Y-03(P-28): Takuro Horii (Institute for Molecular and Cellular Regulation,Gunma University)
Generation of epigenetic disease model mice by dCas9-SunTag epigenome
editing system

15:55-16:10

Y-04(P-04): Keisuke Shimada (Research Institute for Microbial Diseases,Osaka University)
Molecular mechanism of mitochondrial sheath formation revealed throughgene-edited mice

16:10-16:30

Coffee BreakSession 3:

Cancer Biology and Regulation

Chairs:Eiji Hara (Research Institute for Microbial Diseases/ Immunology Frontier Research Center, OsakaUniversity)
Yusuke Maeda (Research Institute for Microbial Diseases, Osaka University)

16:30-16:55

S-06: Kunio Matsumoto (Cancer Research Institute of Kanazawa
University)
Macrocyclic Peptide-Based Inhibition and Nano-Imaging of HGF

16:55-17:10

Y-05(P-10): Masanori Ikeda (Institute of Development, Aging and Cancer,Tohoku University)
Dysregulation of kinetochore structure related to chromosomal instability incancer cells

17:10-17:25

Y-06(P-12): Takeharu Sakamoto (The Institute of Medical Science, The
University of Tokyo)
Mint3 in stromal cells promotes metastatic niche formation

17:25-17:40

Y-07(P-13): Tatsunori Nishimura (Cancer Research Institute of KanazawaUniversity)
Cancer treatments targeting mitochondrial enzymes of one-carbon
metabolism

17:40-17:55

Y-08(P-16): Shinpei Kawaoka (Institute for Frontier Life and MedicalSciences, Kyoto University)
Utilizing enhancer genetics to understand the mechanisms underlying cancerdependent physiological alteration in host organs

18:00-20:00

Welcome Reception at 2F Restaurant Minerva
7Thursday, October 3, 2019
Session 4:
Chairs:Cellular Signaling and Development

Tohru Ishitani (Research Institute for Microbial Diseases, Osaka University/ Institute for Molecularand Cellular regulation, Gunma University)
Daisuke Yamazaki (Research Institute for Microbial Diseases, Osaka University)

09:00-09:25

S-07: Takehiko Sasaki (Medical Research Institute, Tokyo Medical andDental University)
Molecular dissection of phosphoinositides

09:25-09:50

S-08: Tohru Ishitani (Research Institute for Microbial Diseases, Osaka
University/ Institute for Molecular and Cellular regulation, GunmaUniversity)
Cell competition corrects noisy Wnt morphogen gradients to achieve robust
patterning

09:50-10:15

S-09: Yusuke Ono (Institute of Molecular Embryology and Genetics,
Kumamoto University)
Positional memory governs stem cell function in adult skeletal muscle

10:15-10:35

Coffee break

10:35-10:50

Y-09(P-24): Taku Sato (Medical Research Institute, Tokyo Medical andDental University)
Regulated IFN-signal preserves stemness of intestinal stem cells

Special Lecture
Chair:

Taroh Kinoshita (Research Institute for Microbial Diseases, Osaka University)

10:50-11:30

Yasu S. Morita (University of Massachusetts Amherst, USA)
Where Do You Build the Wall? Membrane Domains for SpatiotemporallyCoordinated Cell Envelope Biogenesis in Mycobacterium tuberculosis

11:30-12:30

Luncheon Poster Session at 3F Main conference room
(Complimentary light meal and soft drinks)

Session 5:Immune Regulation and DiseasesChairs: Kazuhiro Suzuki (Immunology Frontier Research Center & Research Institute for Microbial Diseases,Osaka University)
Hisamichi Naito (Research Institute for Microbial Diseases, Osaka University)

12:30-12:55

S-10: Shinichiro Sawa (Medical Institute of Bioregulation, Kyushu University)
RANKL+ mesenchymal cell is the genuine lymphoid tissue organizer cell inthe developing lymph node8

12:55-13:20

S-11: Seiji Fukumoto (Institute of Advanced Medical Sciences, TokushimaUniversity)
FGF receptor 1 works as a phosphate sensor to regulate serum phosphate level

13:20-13:35

Y-10(P-21): Daisuke Sugiura (Institute of Advanced Medical Sciences,Tokushima University)
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for
optimal T cell response

13:35-13:50

Y-11(P-34): Shinjiro Hino (Institute of Molecular Embryology and Genetics,Kumamoto University)
The roles of flavin-dependent demethylases in metabolic reprogramming

13:50-14:05

Y-12(P-23): Motoko Unoki (Medical Institute of Bioregulation, KyushuUniversity)
Relationship between the CDCA7/HELLS chromatin remodeling complex
and NHEJ in molecular pathogenesis of ICF syndrome

14:05-14:15

Poster Awards Ceremony
Yoshiharu Matsuura (Director of Research Institute for Microbial Diseases,Osaka University)

14:15-14:20

Closing Remarks
Sho Yamasaki (Research Institute for Microbial Diseases/ Immunology
Frontier Research Center, Osaka University)

9