HEALTH - FOOD

H E A LT H Y I N F L A M M AT O R Y R E S P O N S E

B I O A V A I L A B L E

CASPEROMEB O S W E L L I C

A C I D S

Please note this documentation is available for various countries all over the world and hence it may containstatements or product classification not applicable to your country. The claims made are in reference to ingredients
only, hence they do not refer to finished products and they may not comply with Regulation EC n. 1924/2006.
The marketer of any finished product containing any ingredient is responsible for assuring that thedestination of the product and the claims made for the finished product are lawful and comply withall applicable laws and regulations of the country or countries in which the product is to be sold.

®

SPECIFICATIONSCASPEROME® is standardized to contain:≥25% of triterpenoid acids by HPLC
RECOMMENDED USE AND DOSE
CASPEROME® is a yellow powder andmay be utilized in a variety of supplement
formulations.
Recommended dose: 250-500 mg/day
TRADEMARKSCASPEROME® is a trademark of Indena
S.p.A. and its logo and usage guidelines areavailable from Indena.
References
1Buechele B. et al. J Chromatogr B 2003; 795: 355-62
2Riva, A., et al. Eur Rev Med Pharmacol Sci 21.22 (2017): 5258-5263.
3Lazzaro F. GIOT 2014;40:141-150
4Lazzaro F., Loiero M. GIOT 2014;40:249-257
5Safayhi H. et al. J Pharmacol Exp Ther 1992; 261: 1143-6
6Tausch L. et al. J Immunol 2009; 183: 3433-42
7Fahmi H. Curr Opin Rheumatol 2004; 16 (5): 623-7
8Gupta I. et al. Eur J Med Res 1997; 2 (1): 37-43
9Gupta I. et al. Planta Med 2001; 67 (5): 391-5
10Khajuria A. et al. Vaccine 2007; 25 (23): 4586-94
11Gerhardt H. et al. Z Gastroenterol 2001; 39: 11-7
12Sengupta K. et al. Arthritis Res Ther 2008; 10 (4): R85
13Hüsch J. et al. Fitoterapia 84 (2013) 89-98
14Gerbeth K. et al. Fitoterapia 84 (2013) 99-106
15Riva, A., et al. Phytomedicine 23.12 (2016): 1375-1382.
16
Pellegrini, L., et al. Eur Rev Med Pharmacol Sci 20.12 (2016): 2695-2700.
17
Belcaro G. et al. Eur Rev Med Pharmacol Sci 21(9), 2249-54. 5 201718Riva, A., et al. Minerva gastroenterologica e dietologica 65.1 (2019): 30-35.

is formulated with Phytosome® technology to achieve
optimized absorption.

muscoskeletal health.2 Furthermore, in combination
with sodium hyaluronate, collagene and glucosamine,has been shown to be supportive against elbow andtendon challenges;3,4

DPR0173 - 04/2012*04/2019

CASPEROME® has been shown to support

CASPEROME® has been shown to support gut
health, significantly alleviating the most common
gut discomforts, compared to the best available
managements.16-18
Furthermore in literature is is reported that:
KBA and AKBA are selective 5-lipoxygenase
inhibitor and then capable to manage theinflammatory response function throughleukotriene inhibition.5 Recent findings haveshifted the focus on β-boswellic acid, the majortriterpenoid from the gum-resin, and its capability
to modulate the inflammatory response enzymes
cathepsin (catG)6 and microsomal prostglandin E
synthase (mPGES)-1,7 suggesting that β-boswellicacid plays a major role while the whole bouquet oftriterpenoid acids is important for the beneficial
effects of boswellia;
Boswellia extracts have been
demonstrated to be useful for bowel
related inflammatory responses,8-11 and to
improve physical function in subjects withjoint and tendon challenges.12

trademarks of Indena S.p.A. © 2019, Indena S.p.A.

SCIENTIFIC EVIDENCE
CASPEROME®
issupportedbyover 10 human studies, including
pharmacokinetics.

CASPEROME®, highly standardized in boswellic acids,

Boswellia extracts have been demonstrated
to be effective in the management ofvarious inflammatory response functions
including those that occur in the bowel,
joints, bones, respiratory airways andin the brain, with a mechanism of actionthat involves the modulation of thenatural inflammatory response bothacting on prostanoid synthesis (mPGE2S)
and protein degradation (caspases), andtranscription factors (Nf-κB).

WHAT MAKES CASPEROME® UNIQUE?

® TM

WHAT IS CASPEROME®?
CASPEROME® is a purified mixture oftriterpenoid acids from the gum resinof Boswellia serrata. Given the poorbioavailability of these compounds,1 Indena
has formulated the extract with Phytosome®
technology to optimize their absorption.

The bioavailability of boswellic acids fromCASPEROME® is greatly optimized both at the plasma
and at the tissue level.13-15

casperome.info
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