PharmaceuticalPureFlo® Z-SeriesMid-Size CapsuleFilters

Typical Uses
Applications
Prefiltration
Bioburden Reduction
Sterile Filtration

PureFlo® Z-Series Mid-sized Capsule Filters are gammastable and ideally suited for integration into single-use
applications. These filter capsules feature an asymmetrichydrophilic PES membrane that demonstrates exceptional
capacity and flow performance in liquid applications. The
Z-Series Mid-Size Capsule Filters offer mid-scale filtration ina variety of applications in the biopharmaceutical industry.
The Z-Series product family has been designed for easy
pre- and post-use integrity testing, assuring easy wetting for
quick and accurate integrity test results.

Process Fluids*
WFI
BufferCell culture medium
Bulk drug substance
Final drug product*Chemical compatibility information available upon request.

The compact design and available inlet and outlet fittings
allow efficient integration of Z-Series Mid-sized Capsules
Filters into a wide range of single-use systems. Z-Series
Mid-sized Capsule Filters provide biopharmaceuticalmanufacturers with a filtration solution configured to meettheir process needs.

Materials of Construction

Media:Polyethersulfone (PES)Media Supports:
PolyesterCage, Core, and Shell: Polypropylene
End Caps:
Nylon
O-Rings:
Silicone

Fitting Connections

See ordering guide for availability. (Custom adaptors available upon request)

Nominal Dimensions

Body Length: 52 mm (1.5”) to 257 mm (10”) (See ordering guide for details) Diameter: 70 mm (2.75”)

Effective Filtration Area(Single-layer)

1.5”: 710 cm2 (0.76 ft2); 2.5”: 1400 cm2 (1.51 ft2); 5.0”: 2700 cm2 (2.91 ft2); 7.5”: 4100 cm2 (4.41 ft2); 10”: 5400 cm2 (5.81 ft2)

Operating ConditionsIntegrity Testing*

Maximum Operating Pressure

Liquid: 5.5 bar (80 psi) at 22°C (72°F)

Maximum Forward Differential Pressure

5 bar (72 psi) at 22°C (72°F)

Maximum Reverse Differential Pressure

3 bar (44 psi) at 22°C (72°F)

Maximum Operating Temperature

80°C (176°F)

0.1 μm (see ordering guide for grades)

60% isopropyl alcohol bubble point ≥ 1.6 bar (23 psi) using air at 22°C

0.2 μm (see ordering guide for grades)

Water bubble point ≥ 3.5 bar (50 psi) using air at 22°C

USP Class VI

All components or raw materials used in this product conform to the requirements of USP Class VI
Biological Reactivity Tests for Plastics.

USP Cleanliness

Effluent from this product meets the requirements for a “non-fiber releasing” filter as defined by 21 CFR 210.3 (b) (6) and theharmonized requirements set forth by the USP <788>, EP, and JP for Particulate Matter in Injections.

Bacterial Endotoxins

An aqueous extraction of this product contains <0.25 EU/ml as determined by the Limulus Amebocyte
Lysate (LAL) Test.

Bacterial Retention

0.1 μm and 0.2 μm grades are quantitatively retentive towards Brevundimonas diminuta (ATCC #19146) at a minimum challenge
level of 107 CFU per cm2 of filtration area, consistent with ASTM F838-05.

Sterilization

This product can be autoclaved up to 25 cycles at 125 °C (257 °F) for 30 minutes. This product is compatible with gamma
irradiation up to 50 kGy.

*All filters are 100% integrity tested.

FILTRATION TECHNOLOGIESPureFlo® Z-Series Mid-size Capsule Filters
PureFlo Z-Series Mid-size Capsule Filters Ordering Guide

Filtration Media Grades
SINGLE LAYERPES (S)
S004 = 0.04 μm
S010 = 0.1 μm
S020 = 0.2 μm
S045 = 0.45 μm
S065 = 0.65 μm
S080 = 0.8 μm
S120 = 1.2 μm

DUAL LAYER
PES with built-in (fine) PES
prefilter (ZS)
ZS010 = 0.1 μm
ZS020 = 0.2 μm
ZS045 = 0.45 μm

PES with built-in (coarse) PES
prefilter (XS)
XS010 = 0.1 μm
XS020 = 0.2 μm

Uniform particle size distribution

Wide particle size distribution

Lowest contaminant load

Highest contaminant load

PureFloCapsuleFilterSZV =Z-Series
CapsuleInternal
Inlet
FilterLength Fitting

Filter Media Grade
Select from Filtration Media
Grades (above)

H = 1.5”
S = 2.5”
L = 5”
E = 7.5”
K = 10”

1H
1Q
2H
2N
2Q
2QP
2QF
3H
4H
4Q
5H
MTSTTC

Outlet Fitting
1H = 1/8” hose barb
1Q = 1/8” male quick coupling
2H = 1/4” hose barb
2H-FB = 1/4” hose barb with filling bell
2H-FC = 1/4’’ hose barb with filling bell with cap
2N = 1/4” MNPT
2Q = 1/4” male quick coupling
2QP = 1/4” male quick coupling (for plastic latch)
2QF = 1/4” female quick coupling with metal latch
3H = 3/8” hose barb
3H-FB = 3/8” hose barb with filling bell
3H-FC = 3/8’’ hose barb with filling bell with cap
4H = 1/2” hose barb
4Q = 1/2” male quick coupling (for plastic latch)
5H = 9/16” hose barb
MT = 1/2” tri-clamp
ST = 1.5’’ tri-clamp (high temperature PP) with SS insert
TC = 1.5’’ tri-clamp

Options
Vent & Drain- N = No vent/drain- NI = No vent/drainnear inlet- NO = No vent/drainnear outlet(Leave blank for onevent/drain near inlet
and one vent/drain nearoutlet)

Example: SZVZS020STCTC (SZV Z-Series Pharma Grade Capsule, 0.2 μm PES final membrane with built-in (fine) PES prefilter, 2.5” internalfilter, 1.5” tri-clamp fittings inlet/outlet)
Custom adapters are available upon request.

Saint-Gobain Performance Plastics
Filtration Technologies
50 W. Watkins Mill Rd
Gaithersburg, MD 20878 USA
Tel: (301) 407-2720
Fax: (240) 566-5774
www.filtration-fls.saint-gobain.com

IMPORTANT: It is the user’s responsibility to ensure the suitability and safety of Saint-Gobain Performance Plastics
products for all intended uses and that the materials to be used comply with all applicable regulatory requirements.
This product is not intended for use in or with a medical device or to diagnose, treat, cure, or prevent any disease.
Saint-Gobain Performance Plastics assumes no responsibility for any product failures that occur due to misuseof the materials it provides arising out of the design, fabrication or application of the products into which thematerials are incorporated.
WARRANTY: Except for products which have a specific written warranty, Saint-Gobain Performance Plastics
products are sold without any guaranty and/or warranty. The only obligation under any applicable productwarranty will be to replace any portion proving defective, or at our option, to refund the purchase price thereof.
SAINT-GOBAIN PERFORMANCE PLASTICS DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND
FITNESS FOR A PARTICULAR PURPOSE.

PureFlo, C-Flex, Pure-Fit, and SIB are registered trademarks of Saint-Gobain Corporationor an affiliated company.
Copyright 2017 Saint-Gobain. All rights reserved.

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