ISSN 0914-9198

Journal ofTOXICOLOGICPATHOLOGY
http://www.japantoxpath.org/en/publication/jtp/

Vol. 28
No. 3Summer2015
Published by
The Japanese Society of Toxicologic Pathology
The Journal of Toxicologic Pathology has been selected for coverage in Thomson Reuters
products and services. Beginning with volume 21, number 1, year 2008, the journal isindexed and abstracted in:Ƈ Science Citation Index Expanded (also known as SciSearch ®)Ƈ Journal Citation Reports/Science Edition
Ƈ Biological Abstracts
Ƈ BIOSIS Previews

Description
The Journal of Toxicologic PathologyLVDQRI¿FLDOSHULRGLFDOMRXUQDORIWKH-DSDQHVH6RFLHW\RI7R[LFRORJLF3DWKRORJ\7KHMRXUQDODFFHSWV RULJLQDO SDSHUV VKRUW FRPPXQLFDWLRQV FDVH UHSRUWV DQG UHYLHZ DUWLFOHV  2QH YROXPH SXEOLVKHG HDFK \HDU LV FRPSRVHG RIIRXUQXPEHUV0HPEHUVRIWKH6RFLHW\DUHHQWLWOHGWRUHFHLYHDOOSXEOLFDWLRQVLQH[FKDQJHIRUKLVRUKHUPHPEHUVKLSIHH$OODUWLFOHVSXEOLVKHGLQWKH-RXUQDORI7R[LFRORJLF3DWKRORJ\UHSUHVHQWWKHRSLQLRQ V RIWKHDXWKRUV V DQGVKRXOGQRWEHFRQVWUXHGWRUHÀHFWWKH
RSLQLRQRIWKH6RFLHW\The Journal of Toxicologic PathologyKDVEHHQVHOHFWHGIRUFRYHUDJHLQ7KRPVRQ5HXWHUVSURGXFWVDQGVHUYLFHV%HJLQQLQJZLWKYROXPHQXPEHU\HDUWKHMRXUQDOLVLQGH[HGDQGDEVWUDFWHGLQ6FLHQFH&LWDWLRQ,QGH[([SDQGHG DOVRNQRZQDV6FL6HDUFK®
-RXUQDO&LWDWLRQ5HSRUWV6FLHQFH(GLWLRQ
%LRORJLFDO$EVWUDFWV
%,26,63UHYLHZV
Mailing address 0DVDPL6X]XNL'903K'(GLWRULQ&KLHI
(GLWRULDO2I¿FH-RXUQDORI7R[LFRORJLF3DWKRORJ\FR3XEOLFDWLRQ&HQWHU,3(&,QF6XJDPR7RVKLPD
7RN\R-DSDQ
Journal of Toxicologic PathologyKRPHSDJHKWWSZZZMDSDQWR[SDWKRUJHQSXEOLFDWLRQMWS)UHHDFFHVVWRIXOOSDSHUVRI:KROHLVVXHKWWSVZZZMVWDJHMVWJRMSEURZVHWR[9RO  WRSUHVHQWKWWSZZZQFELQOPQLKJRYSPFMRXUQDOVNotice for photocopying
,I\RXZLVKWRSKRWRFRS\DQ\ZRUNRIWKLVSXEOLFDWLRQ\RXKDYHWRJHWSHUPLVVLRQIURPWKHIROORZLQJRUJDQL]DWLRQWRZKLFKOLFHQVLQJRIFRS\ULJKWFOHDUDQFHLVGHOHJDWHGE\WKHFRS\ULJKWRZQHU
$OOXVHUVH[FHSWWKRVHLQ86$! -DSDQ$FDGHPLF$VVRFLDWLRQIRU&RS\ULJKW&OHDUDQFH,QF -$$&&
$NDVDNDFKRPH0LQDWRNX7RN\R-DSDQ
3KRQH)$;(PDLOLQIR#MDDFFMS8VHUVLQ86$! &RS\ULJKW&OHDUDQFH&HQWHU,QF5RVHZRRG'ULYH'DQYHUV0$86$
3KRQH)$;
2QOLQH,661;

Cover:

D 7KHPDVVDOPRVWUHSODFHGWKHSLWXLWDU\JODQGZLWKLQYDVLRQWRWKHVSKHQRLGERQH 6% EXWGLGQRWLQ¿OWUDWHWKHWULJHPLQDOQHUYHV 71 DQGW\PSDQLFFDYLWLHV 7&  î  E 7XPRUFHOOVLQYDGHGWKHVSKHQRLGERQH F 7XPRUFHOOVLQYDGHGWKHPHQLQ[RIWKHFHUHEUXP 0& EXWQRWWKHSDUHQFK\PDRIWKHFHUHEUXP &%  G 6PDOOQHVWVRIQDWLYHDQWHULRUFHOOVZHUHREVHUYHGLQWKHWXPRU DUURZV ZLWKFRQJHVWLRQDQGWKURPERVLV  î 1DWLYHDQWHULRUWLVVXHVZHUHSRVLWLYHIRU&. îLQVHUWHGLOOXVWUDWLRQ  H 7KHWXPRUZDVFRPSRVHGRIVKHHWVRIIXVLIRUPFHOOVZLWKVSLQGOHRU
SOHRPRUSKLFVKDSHGQXFOHLDQGDEXQGDQWHRVLQRSKLOLFF\WRSODVPV0DQ\PLWRWLF¿JXUHVZHUHVHHQLQWKHWXPRUFHOOVDUURZV  î  I %L]DUUHPXOWLQXFOHDWHGJLDQWFHOOVZLWKHRVLQRSKLOLFK\DOLQHGURSOHWVZHUHREVHUYHG DUURZ  î + (VWDLQLQJ 6HH70RURNLet al. S± 