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Cholesterol oxidase(COO-321）
First issue : Apr. 13. 2015
Revised: May. 31. 2022
SDS No.1028F

Safety Data Sheet
1 Chemical Product and Company Identification
Identification of the productProduct CodeSupplier
NameAddress
Department
Phone
Fax
Recommended use and restrictions on use

Cholesterol oxidase
COO-321TOYOBO CO.,LTD.
Osaka Umeda Twin Towers South,
1-13-1 Umeda Kita-ku, Osaka 530-0001, Japan
Biotechnology Overseas Sales and Marketing Department+81-6-6348-3846+81-6-6348-3833
diagnostic product2 Hazard Identification
Most Important Hazards and Effects
GHS classification3

Composition/Information on Ingredients
Substance/Mixture
Chemical Nature
CAS#Concentration or concentration range
Stabilizer, etc
Ingredients Contributing to the Hazard
Common Chemical nameConcentration or concentration range
Chemical formula
CAS#4

The product might cause allergic reactions upon inhaling or skincontact because of the protein contained.
Classification not possible

MixtureCholesterol oxidase9028-76-6
ca. 40% (W/W)
ca. 60% (W/W)
Boric acidca 0.07% (W/W)
H3BO3
10043-35-3

First Aid Measures
Inhalation

Remove to fresh air. Consult a physician when unpleasantness occurs.

Skin Contact

Wash off with plenty of water. Consult a physician when inflammation on
the skin occurs.
Rinse cautiously with water for several minutes. Remove contact lenses,
if present and easy to do. Continue rinsing.
Swill plentiful amount of water or milk for immediate vomiting, consult
a physician.

Eye Contact
Ingestion

5 Fire Fighting Measures
Extinguishing Media
Protection of Firefighters

Water spray, dry chemical powder, or carbon dioxide etc.
Avoid working at leeward.

6 Accidental Release Measures
Personal Precautions
Environmental Precautions
Methods for Cleaning up

Wear protective gear to avoid eye/skin contact and inhalation. Do notwork at leeward.
High concentrated waste fluid should not be directly discharged into
Take up under vacuum using dust collecting filter, wash residual spillwith copious amounts of water. Use cloth, paper or anything similar tosoak up the solution leaking out of the container.

7 Handling and Storage
Handling
Technical Measures
Precautions
StorageTechnical Measures
Incompatible substances and mixtures
Storage Conditions
Packaging Materials

Wear protective gear to avoid eye/skin contact and inhalation. Do notdrop the container to prevent the content popping out.
None specified.
Keep sealed container in freezer.
None specified.
Store under -20℃ to avoid deactivating.
Use the initial container of the product.

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Cholesterol oxidase(COO-321）
First issue : Apr. 13. 2015
Revised: May. 31. 2022
SDS No.1028F

Safety Data Sheet
8 Exposure Controls/Personal Protection
Engineering Measures
Personal Protective Equipment
Respiratory Protection
Hand Protection
Eye Protection
Skin and Body Protection

Provide shower and eye washing apparatus nearby.
Protecting mask.
Protecting gloves(rubbers or plastic gloves etc.).
Safety goggles.
Long sleeve working wear.

9 Physical and Chemical Properties
Physical State
Colour/Odour
pHDecomposition Temperature
Flash PointDensity
Solubility

PowderYellow/No odour
ca. pH7.0 in the case of 10 mg/ml in water.
No information available.
No information available.
No information available.
Easily soluble in water.

10 Stability and Reactivity
Stability

Possible hazard reactions at specificcondition
Conditions to avoid
Materials to avoid
Hazardous Decomposition Products

Stable at temperatures below -20℃.When left for long at room
temperature,proteins might be degraded, which does not cause any
hazardous reaction.
Not specified.
Prolonged storage at temperatures higher than room temperature and highhumidity.
Any materials which dissolve or destroy proteins such as strong acid oralkali.
No information available.

11 Toxicological Information
Acute Toxicity
Skin corrosion/irritation
Eye damage/irritation
Sensitization

No information available.
No information available.
No information available.
Might cause allergic reactions upon inhaling or skin contact because of
the protein contained.
No information available.
No information available.
No information available.
No information available.

Germ cell mutagenicity
Carcinogenicity
Toxic to reproduction
Specific target organ toxicity(Single exposure)Specific target organ systemic
No information available.
(Repeated exposure)
Aspiration toxicity
No information available.
The information on the boric acid is shown below.
Acute Toxicity (Oral)
LD50 2660mg/kg(Rat)
Skin corrosion/irritation

Guinea pig skin irritation tests (exposure duration unknown) : At 24
and 72 hours, moderate irritation

Serious eye damage/irritation

Irritates the human eye (though the severity of the effects andrecovery period are not presented).
in vivo: Mouse bone marrow cell mutagenicity tests (micronucleustests): Negativein vitro: Reverse mutation test using bacteria, gene mutation test andchromosome aberration test using mammalian cultured cells: Negative

Germ cell mutagenicity

Carcinogenicity
Toxic to reproduction

ACGIH classified as Category A4 (as inorganic borate compounds)
Mouse:Reproductive Assessment by Continuous Breeding, Rat:3 generation
reproductive toxicity study: Adverse effects on reproduction
Rat:Developmental toxicity:Teratogenicity is observed.

Specific target organ systemic toxicity Human: Nausea, vomiting, abdominal pain and diarrhea, central nervous
system depression, convulsion and respiratory irritation.
Animal studies: Slight respiratory irritation was observed.
(Single exposure)3/3

Cholesterol oxidase(COO-321）
First issue : Apr. 13. 2015
Revised: May. 31. 2022
SDS No.1028F

Safety Data Sheet
Specific target organ systemic toxicity Human: No information available. Animal studies:Oral administration,
adverse effects were observed at over the guidance dose for category 2.
(Repeated exposure)Though this corresponds to "not classified" in oral route, noinformation of the effects via the other routes of administration.

12 Ecological Information
Acute hazards to the aquatic environment No information available.
Protein and other organic ingredients are biodegradable and does not
Persistence /Degradability
remain on the environment for long.

13 Disposal Considerations
Waste from Residues
Contaminated packaging

Dispose of in accordance with all applicable local and national lawsand regulations.
Wash with copious amounts of water and waste conforming to local
regulations depending on the type of the material.

14 Transport Information
International Regulations
Domestic Regulations
Specific Precautions

None specified (Not classified as hazardous material as per the UN
recommendation).
None specified.
Keep at temperatures below -20℃.

15 Regulatory Information
REACH(EU)Regulations

SVHC：Boric acid
Follow all of laws and regulations in your country.

16 Other Information
Notice

The contents specified here is made based on the documents, information
or data which are currently available and subject to revision in thefuture. TOYOBO makes no warranty and assumes no liability whatsoever inconnection with any use of this information.