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Unlock the worldof 3D cell culture

BIO ONE

Unlock the world of 3D cell culture

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BIO ONE

Embark on ajourney of scientificinnovation with 3Dbioprinting

Traditional methods like 2D cell culture or animal experiments havetheir limitations, leading to a growing need for more precise in vitro
models in the field of life sciences. 3D bioprinting is a technology thatempowers researchers to construct more physiologically relevant
models, all while reducing costs and ensuring the delivery of moreaccurate data.

Unlock the world of 3D cell culture

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Unlock the world of3D cell culture withBIO ONEWith exceptional cooling capabilities, precision syringe-based
extrusion and an intuitive, easy-to-use desktop software in DNA
Studio Core, the BIO ONE brings a new level of ease in the transition to 3D cell culture. Designed for printing temperature-sensitive materials like collagen, the BIO ONE enables scientists todevelop 3D models that replicate in vivo environments, contributing to accelerated discoveries.

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Construct flexibility

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Robust, reliable, and small enough to fit in your biosafety cabinet oron the benchtop, the BIO ONE is perfect for printing droplets, droplet arrays and lattices, allowing easy production of organoids, spheroids and tissue constructs to accelerate your research.

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Eliminate the barriers to 3D cell culture withthese essential features

COOLING CAPABILITIESMATERIAL FLEXIBILITY

PRECISION EXTRUSION

Rapidly cool the BIO ONE printhead down to0 °C and maintain the temperature throughout the print. With a novel design, ensure
temperature stability till the tip of the nozzle
from start to finish.

The BIO ONE is designed to be an open
material platform, meaning that users canload any material into a syringe and dispense it, including temperature sensitive
materials like collagen.

Enable total control over your print with thehigh-precision mechanical extrusion of theBIO ONE. The mechanism boasts an impressive 0.1 μL volume step.

HEATED PRINTBEDMAXIMIZED REPRODUCIBILITY

POWERED BY DNA STUDIO

Extend construct stability and cell viability
for heat-responsive materials through thermal crosslinking, using the built-in printbed
heating ranging from RT – 65 °C.

Enable highly reproducible structures withlimited print-to-print variation and humanerror, by leveraging both the precision extrusion and saved protocols in the software.

Powered by DNA Studio Core, the BIO ONE
has ease-of-use as its core principle, whichmakes it easier than ever to enter the worldof 3D cell culture.

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6PRECISION IN EVERY PRINT

The BIO ONE
Printhead
Combining the syringe-based
mechanism with tight temperature control, the BIO ONE printhead ensures high precision inprinting. The technology enables
not only accurate printing ofboth low and high viscous materials, but it also maintains consistent flow rates of temperaturesensitive materials, ensuringconsistency across every print.

The motor’s rapid and precise
control features an impressive 0.1
μL volume step, allowing you todecide the exact volume deposited into the well-plate or petri
dish.
The autocalibration capabilitiesof the instrument enable increased workflow efficiency andwalkaway capabilities once theprints are defined.

Unlock the world of 3D cell culture

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CORE
With DNA Studio Core, users have an easy-to-use
desktop software, which guides them throughthe entire bioprinting journey.

FEATURE HIGHLIGHTS̶Multiple printing modes facilitating droplet
or 3D construct printing̶Compatible with multiple file types

̶User-friendly UI for an intuitive experience8CELLINKBioinks andBiomaterials
AN OPEN MATERIAL
PLATFORMBIO ONE is built from theground up with flexibility inmind, with the intent thatusers can add any biomaterial and dispense it. Thisis achieved through DNA
Studio Core, where users
can easily modify printing
parameters like retraction
volume and extrusion rate.
Couple this with printheadcooling capabilities and aheated printbed to further
the system’s biomaterialflexibility.
Take full control of yourbiomaterial composition
with our bioink components and build the perfect bioink or leverage
our ready to print bioinks,
which are specially optimized for printing fidelity
and maintaining cell viability.

Explore CELLINK’sbiomaterial portfolio.

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9Unlock the world of 3D cell culture

Unlock the advantages of 3D cell culture andreap the benefits of reproducibility for greater
insights across applications

01. TISSUE ENGINEERING

02. MATERIAL SCIENCE

03. DRUG DISCOVERYEngineering tissuemodels

Developing the next generation ofbiomaterialsAccelerating the drug
discovery process

Bioprinting has become an essential toolin tissue engineering. With its user-friendly
interface, BIO ONE is the ideal stepping stone
to start creating 3D tissue models. Easily
develop tissue models like skin and cartilage
to study regenerative properties or develop
alternatives to animals for cosmetic testing.

The open platform of BIO ONE allows users
to freely develop and readily use their own
materials, without any workarounds or fees.
Relying on non-proprietary syringes andnozzles, it is possible to print with any bioink.
The software allows fine tuning of various
printing parameters, including volume andflow, which means you can create protocols
of your choice. This ensures the system canbe used in multiple areas of material sciences, from bioink development and soft robotics to smart materials.

With compatibility for printing on up to 384well plates, BIO ONE enables researchers
within the field of drug discovery to easily
increase the number of replicates and gain amore accurate understanding of compound
activity. This accelerates drug discovery processes by ensuring only the best candidates
are carried along to clinical trials. Simply
print an array of droplets to investigate drugdelivery in easily reproducible in vitro models.

10CELLINKJoin the ever-expanding community of scientists
embracing 3D bioprinting for transformative
breakthroughs in biomedical research.
“Having access to their amazing
products and exceptional service
has been helpful, and we wantto continue the relationship withCELLINK.”“We have a lot of fun working
with CELLINK. We’ve presented
them with problems, and they’veworked with us to fix them, like acollaboration.”– CARCINOTECH, UK– RONAWK, USAChoosing CELLINK
as your bioprinting
partner“Although the technology is aneasy-to-use, plug-and-play, thereal value is in the CELLINK
team’s support and expertise.”– DR. JOSHUA CHOU,UNIVERSITY OF TECHNOLOGYSYDNEY, AUSTRALIACELLINK’s global team of application specialists are ready toprovide support when you need
it. With multiple support packages available to meet your needs,
rest assured you are not alone
on this journey. A member of our“The access to a bioprinter has
allowed us to ask more interesting research questions, and has
enabled us to be able to do ourcurrent research.”– DR. DANIEL AILI, LINKÖPING
UNIVERSITY, SWEDEN

team can reach out within hours
of recieving your request. We are
happy to work by phone, overemail, through video chat andon-site to perform installations,repairs and preventive maintenance or application support.

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CELLINK

Unrivaled portfolio foryour research needs
As the bioprinting leader, wetake pride in providing the mostextensive portfolio of bioprinting solutions to meet the diverse
needs of laboratories worldwide.
Our portfolio of light-based andextrusion-based bioprinters andbiodispensers, is designed tocater to a spectrum of needs,
ensuring that you have the righttools to achieve your project’s
goals.

Whether you are a newcomer tobioprinting and looking to produce simple and straightforward
models or if you are advancing
into high throughput or complex
model printing, we have the solution for you.

Explore our diverse range ofbioprinters and revolutionize
your research.

Learn more on
how the BIO ONE
can support yourresearch.

Application
Technicalnote
specifications

WEBEMAIL

PHONE

www.cellink.com

sales@cellink.com

US: +1 (833) CELLINK
EU: +46 311 287 00