ISSN 0914-9198

Journal ofTOXICOLOGICPATHOLOGY
http://wwwsoc.nii.ac.jp/jstp3/english/Journal.html

Vol. 23
No. 1
Spring2010

Published by
The Japanese Society of Toxicologic Pathology

Editor-in-Chief
Dai Nakae, Tokyo
Editor Emeritus
Eisei Ishikawa (1988–1997)
Former Editors-in-Chief
Kunio Doi (1998–2003)
Kunitoshi Mitsumori (2003-2007)
Editorial Board (Editors)
Wijit Banlunara, Bangkok
Satoshi Furukawa, Saitama
Paul-Georg Germann, Barsbüttel
Katsumi Imaida, Kagawa
Keisuke Izumi, Tokushima
Hijiri Iwata, Itingen
Jong-Koo Kang, Cheongju
Osamu Katsuda, Nara
Wolfgang Kaufmann, Ludwigshafen
Yuji Oishi, Osaka
Kumiko Ogawa, TokyoJin Ren, Shanghai
Hiroshi Satoh, TokyoJohn Curtis Seely, North Carolina
Makoto Shibutani, Tokyo
Kazumoto Shibuya, Tokyo
Masami Suzuki, Shizuoka
James Swenberg, North Carolina
Kazutoshi Tamura, Shizuoka
Leander Tryphonas, Ontario
Tetsuya Tsukamoto, Aichi
Masahiro Tsutsumi, Nara
Klaus Weber, Itingen
Midori Yoshida, Tokyo
Naomi Yoshimi, Okinawa
Katsuhiko Yoshizawa, Osaka

Description
The Journal of Toxicologic Pathology is an official periodical journal of the Japanese Society ofToxicologic Pathology. The Journal accepts original papers, short communications, case reports andreview articles. One volume published each year is composed of four numbers. Members of the Society
are entitled to receive all publications in exchange for his or her membership fee. All articles publishedin the Journal of Toxicologic Pathology represent the opinion(s) of the author(s) and should not be
construed to reflect the opinion of the Society.
Dai Nakae, M.D., Ph.D., Editor-in-Chief
Editorial Office, Journal of Toxicologic Pathology
c/o Publication Center, IPEC, Inc.
1-24-12 Sugamo, Toshima, Tokyo 170-0002, Japan
Journal of Toxicologic Pathology homepage: http://wwwsoc.nii.ac.jp/jstp3/english/Journal.html
Free access to full papers ofVols. 1 (1988)-10 (1997): http://www.journalarchive.jst.go.jp/japanese/jnltop_ja.php?cdjournal=tox1988

Mailing address:

Vol. 11 (1998) or later: http://www.jstage.jst.go.jp/browse/tox/-char/en
Notice for photocopying
If you wish to photocopy any work of this publication, you have to get permission from the following organization towhich licensing of copyright clearance is delegated by the copyright owner.
<All users except those in USA> Japan Academic Association for Copyright Clearance, Inc. (JAACC)
6-41 Akasaka 9-chome, Minato-ku, Tokyo 107-0052, Japan
Phone 81-3-3475-5618 FAX 81-3-3475-5619 E-mail: info@jaacc.jp<Users in USA>

Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA
Phone 1-978-750-8400 FAX 1-978-646-8600

Online ISSN 1881-915X

Cover: Keratoconus in a Cynomolgus Monkey. a) Macroscopic appearance of the left eye in the normal monkey. b) Macroscopic appearance of the right eye in the present case. The cornea becomes conical and protrudes from the center. c) Macroscopic appearance ofthe left eye in the present case. Severe edema with opacity covers the corneal surface. d) Macroscopic appearance of the face in thepresent case. The upper eyelid and forehead have wide-ranging erythema. Both corneas become conical and protrude from thecenter. Acute edema occurred in the left eye. (See Kodama R, et al. p53–60)