THE FUTURE OF
MEDICINE IS HERE

What is Bioink? A bioink is a biomaterial that is suitable for bioprinting

with cells and provides a temporary or permanent support to the cells while they produce theirown extracellular matrix. Bioinks based on biopolymers, such as collagen, gelatin, hyaluronan,silk, alginate and nanocellulose, are known for their favorable biocompatible properties and are
attractive biomaterials for cell encapsulation and 3D bioprinting. These bioinks provide anaqueous 3D environment with biologically relevant chemical and physical signals, mimicking
the natural extracellular matrix environment. Signiﬁcant advances in 3D bioprinting technology as well as the development of new bioinks have made it possible to bioprint complex 3D
tissue structures.

Why Bioprinting? The innovative methods for engineering humantissues and organs can have a profound eﬀect on the future of medicine. 3D bioprinting isconsidered a revolutionary technology for advancing and accelerating progress in the ﬁeld oftissue engineering and regenerative medicine, and thus, the future of medicine. We believethat we can create this future through a collaborative spirit and by putting our combined
expertise to the service of humanity.
The future is created in the present and it belongs to the doers, those who continue moving
forward in order to see their vision come to realization. It’s not that we see the future and thenmove towards it. We move in order to see it.

WELCOMETO THE WORLD OF
BIOPRINTINGWE ARE CELLINKWe are a team of entrepreneurs, scientists, engineers and pioneers,pushing the limits for what’s possible, paving the way for the futureof regenerative medicine.
With our 3D bioprinters and bioinks, we will open the possibility formore extensive medical research. Together with our collaborators, inhundreds of labs in over 45 countries, we work side by side toensure quality and support.
Our compassion for humans and drive to create an impact will pave
the way for continued growth.

“There was a clear diﬀerence in CELLINK's customer approach, productrobustness, and conﬁdence in their products, all of which made CELLINK
stand alone in the market of 3D bioprinting. We trusted the company andnow looking back we think it was not a wrong decision to go withCELLINK.”- Dr.Nath, Harvard Medical School“Thanks CELLINK for engaging the students and holding this successful
workshop on bioprinting”- Ric Levato, UMC Utrecht“CELLINK has taken our feedback and adapted their system while being
actively engaged in the process”- Dr. Grande, The Feinstein Institute for Medical Research

THE FUTURE OF 3D BIOPRINTING
Robust, reliable and small enough to ﬁt on your benchtop, the powerful INKREDIBLE+ 3D bioprinter is perfect for today’s advanced research
applications. Pair this with the beneﬁt of unrivalled CELLINK customer support and you will see a dramatic increase in your research
productivity in a wide range of applications.
The innovative INKREDIBLE+ oﬀers a pneumatic-based extrusion system with dual print heads and built-in UV LED curing that allows for quick
and easy bioprinting of living tissues. Thanks to our patented Clean Chamber Technology, INKREDIBLE+ oﬀers a sterile internal environment
right on your benchtop. The two heated print heads allow for the use of a wide range of materials and diﬀerent cell types in the same construct.
All of this can be found in a compact, precise and user-friendly system with the INKREDIBLE+.

STERILITY ON YOUR BENCHTOPCELLINK’s Clean Chamber Technology provides a sterile
printing environment without the need for a biological hood.

DIFFERENT CELL TYPES
Two printheads allows the user to print with diﬀerent cell types
in the same structure.

WIDE RANGE OF MATERIALS
Operating at temperatures up to 130 degrees Celsius, heatedprintheads allow you to print with a wide range of materials.

EASY CROSSLINKING
The built-in UV Crosslinking System with wavelengths of 365
nm and 405 nm provides a quick and convenient way to initiate
photo crosslinking.

SPACE ECONOMY
Powerful and compact, the small footprint of the INKREDIBLE+ﬁts easily on your benchtop.

PRECISE, ACCURATE AND REPRODUCIBLE
Pneumatic micro-extrusion printheads with high XYZ resolution.

STANDALONE UNIT
The LCD display and manual pressure regulators provide aneasy-to-use standalone unit while retaining the option ofmonitoring the bioprinting process through a computer.

DUAL HEATED PRINTHEADSThe INKREDIBLE+ comes equipped with dual heated printheads, allowing you to bioprint with diﬀerent cell types
and bioinks in the same structure without switching cartridges or pausing the process. As a result, complex, stablestructures can be achieved precisely how you want them and in less time. The INKREDIBLE+ comes with a built-in
system to operate the printheads at temperatures up to 130 degrees Celsius. As a result, a wide range ofbiomaterials can be used, including those that may be too viscous at room temperature.

CLEAN CHAMBER TECHNOLOGYThe INKREDIBLE+ features our patented Clean Chamber Technology, providing a sterile internal environment
without the use of a biological hood. A powerful fan creates a positive air pressure inside the chamber of theINKREDIBLE+. Unﬁltered air is passed through a high-eﬃciency H13 HEPA ﬁlter with a retention rate greater than
99.95% that captures unwanted particles. The chamber is ﬁlled only with ﬁltered air, providing a clean environmentfor 3D bioprinting and cell culturing right on your benchtop.

UV-CROSSLINKING SYSTEMINKREDIBLE+ comes equipped with a built-in UV Crosslinking System that hardens your structure andallows it to be moved without losing its integrity. A wide range of bioinks can be cross linked using the 365
nm LED or 405 nm option. These ideal crosslinking wavelengths are conveniently accessible within thesterile environment of the INKREDIBLE+.

SPACE ECONOMY
We know how valuable lab space is, which is why we packed as much functionality as possible into thecompact bioprinter of the INKREDIBLE+. Dual heated printheads, Clean Chamber Technology, LCD display,built-in UV Crosslinking System, manual pressure regulators and more can all be found within the small
footprint of INKREDIBLE+.

PURPOSEFUL DESIGNINKREDIBLE+ was intentionally engineered to be user-friendly. The
intuitive LCD controller allows you to set up and modify your bioprinting
experiments. Manual pressure regulators provide precise regulation of thedispensing process. The built-in UV Crosslinking System oﬀers a quick andeasy way to strengthen your 3D-printed construct with the touch of abutton.
Together, these features make the INKREDIBLE+ a standalone unit while still retaining the ability to be monitored through a computer withaccompanied software. As always, CELLINK’s incredible customer support
team is also here to help!

EASY PRINTING PROCESSCELL MIXINGBIOPRINTINGCROSSLINKING

Before printing, the cells need to be mixed withthe bioink. We have developed the easiest andmost homogenous way of doing this using ourinnovative CELLMIXER. Put the bioink in a 3
mL syringe and add your cells to suspension
media in a 1 mL syringe. Clip each syringe tothe dispensing unit, connect the mixing unit tothe tip of each syringe and then connect theﬁlling cartridge. Screw all connections so there
is no leakage. Fill the cartridge by gently injecting the ink and cells through the mixing unit.
Your ﬁlling cartridge is now ready for bioprinting and can be disconnected from the mixing
unit.

When cell mixing is done and your cartridge is
ﬁlled, you’re ready to start printing. Screw a
nozzle on to the cartridge and place it in theprinthead after connecting it to the air system.
Conﬁgure the desired print settings using theLCD display. Pressure can also be adjusted
easily during the bioprinting process using thepressure regulator knobs. Follow the procedure to quickly home the XYZ axes, thenchoose the design ﬁle you would like to use
and start printing.

Depending on the material you are printing, you may need to crosslink the printed construct. For UV crosslinking, youcan use the built-in LED with wavelengths of 365 or 405 nm. For othertypes of crosslinking, you can also add
the crosslinking agent directly to yourconstruct.

1 2 3

OUR BIOINKSBIOINKSOURAPPLICATIONS
BioinkCELLINK is the ﬁrst bioink company in the world and isalso the creator of the world’s ﬁrst universal bioink. This
opens the opportunity for scientists to bioprint using anytype of cells.
Today we provide more than 40 diﬀerent sterile andready-to-use bioinks for various applications, from printing cancer models to skin models. Moreover, it is compatible with any 3D bioprinting system.
You can also check out our diﬀerent kits for special applications and needs. The Support kit will enable the fabrication of your 3D constructs from otherwise unprintablematerials and revolutionize your research!

CELLINK A
CELLINK A - RGD
CELLINKCELLINK BONE
CELLINK FIBRINOGENCELLINK FIBRINCELLINK RGD
CELLINK SKIN
CELLINK SKIN+CELLINK LAMININK 111
CELLINK LAMININK 121
CELLINK LAMININK 411
CELLINK LAMININK 521
CELLINK LAMININK+Coll1
CollMAGelMAGelMA A
GelMA C
GelMA HA
GelMA high C
GelXA
GelXA-BoneGelXA-Fibrin
GelXA-Skin
GelXA-LN111
GelXA-LN121
GelXA-LN411
GelXA-LN521
GelXA-LN+GelXG
CELLINK PCL
PLAPLGA
CELLINK Pluronics
CELLINK STARTCELLINK START X
CELLINK Support
CELLINK Xplore
HAMA Kit

CartilageSkin√√BoneMuscle√√√√√√√√√√√√√√√√√

MSCs√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√√

Other Cell
Types

Sacriﬁcial
Material

Thermoplastic
Scaﬀolds√√√√√√√√√√√√√√√√√√√√√√√√√√√√√

BIOVERSE.COBIOVERSE.COEXTENDINGDEVELOPMENTDEVELOPMENTBEYOND
BEYONDYOURYOURLABLAB
EXTENDINGCOLLABORATETOTOACCELERATEACCELERATEPROGRESSPROGRESSCOLLABORATE

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Quickly download 3D models, project ﬁles and printing
protocols to easily set up your next bioprinting projectwith the CELLINK+.

FEATURES
BIOPRINTING
Bioprinting Technology: Pneumatic-based microextrusion system
Printheads: 2 heated, pneumatic-based extrusion printheadsUV Crosslinking System: 1 UV LED curing system 365 nm (405 nm optional)
Printhead Temperature Max: 130° Celsius
Build Volume: 130 x 80 x 100 mm. Printbed has insets for P100 petri dish and multi-well plates.
Positioning Precision: XY: 10 µm [0.0004 in]; Z: 2.5 µm [0.0001 in]Layer Resolution: 100 µm [0.0039 in]Hydrogel’s viscosity range: 0.001 to 250 Pa.S [1 to 250,000 cP]
Max. Operating Pressure: 700 kPa
Set Pressure Range: 5 to 400 kPa
Sensitivity: Within 0.2% F.S. (0.8 kPa)
Repeatability: Within ±1% F.S. (4 kPa)
Minimum Unit Setting: 1 kPa
Pressure Display Units: kPa, MPa, kgf/cm2, bar, psi, inHg and mmHg
Printhead’s Response Time: 5 ms or less (ON), 4 ms or less (OFF)Nozzle Length: Auto-calibration, 6.35 mm [0.25 in] to 38.1 mm [1.5 in]Nozzle Diameter: User dependent, 50 to 1540 µm

SOFTWARE
Software Bundle: Slic3r, Repetier-Host
File Types: STL/OBJ/AMF
Supports: Windows (XP 32 bit/7+), Mac OS X (10.6 64 bit/10.7+) and Ubuntu Linux (12.04+)
Connectivity: USB, SD-card
PHYSICAL SPECIFICATIONS
Frame: Chemically resistant, powder-coated high-grade steel
D x W x H: 330 x 370 x 430 mm (19.1 x 16.5 x 14.7 in)
Shipping Box: 59 x 55 x 43 cm (23 x 21.5 x 17 in)
Shipping Weight: 20 kg (44.5 lbs)
ELECTRICAL
Power Supply Adapter:
Input: 100-240VAC, 50/60Hz, 2.0A
Output: 24VDC, 6.67A, 160W Max
Portable, Oil-free Air Compressor:
EU/UK/AU/CH: 230VAC, 50Hz
US/MEX/CA/JAP/Taiwan: 110VAC, 60Hz
INKREDIBLE+ 3D Bioprinter:
Input: 24 VDC, 6 A
IP-classiﬁcation: IP10
ADDITIONAL FEATURESClean Chamber Technology
Manual pressure regulators
LCD display

WWW.CELLINK.COM+1 (833) CELLINKBoston, USAGothenburg, Sweden

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Arvid Wallgrens Backe 20,

Boston, MA 02110

Gothenburg, 41346

Virginia, USA
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