ISSN 0914-9198

Journal ofTOXICOLOGICPATHOLOGY
http://www.japantoxpath.org/en/publication/jtp/

Vol. 24
No. 4Winter2011
Published by
The Japanese Society of Toxicologic Pathology
The Journal of Toxicologic Pathology has been selected for coverage in Thomson Reuters
products and services. Beginning with volume 21, number 1, year 2008, the journal isindexed and abstracted in:
Science Citation Index Expanded (also known as SciSearch R )Journal Citation Reports/Science Edition
Biological Abstracts
BIOSIS Previews

Editor-in-Chief
Dai Nakae, Tokyo
Editor Emeritus
Eisei Ishikawa (1988–1997)
Former Editors-in-Chief
Kunio Doi (1998–2003)
Kunitoshi Mitsumori (2003-2007)
Editorial Board (Editors)
Wijit Banlunara, Bangkok
Satoshi Furukawa, Saitama
Paul-Georg Germann, Barsbüttel
Katsumi Imaida, Kagawa
Keisuke Izumi, Tokushima
Hijiri Iwata, Itingen
Jong-Koo Kang, Cheongju
Osamu Katsuda, Nara
Wolfgang Kaufmann, Ludwigshafen

Yuji Oishi, Osaka
Kumiko Ogawa, Tokyo
Jin Ren, Shanghai
Hiroshi Satoh, Kanagawa
John Curtis Seely, North Carolina
Makoto Shibutani, Tokyo
Kazumoto Shibuya, Tokyo
Masami Suzuki, Shizuoka
James Swenberg, North Carolina

Kazutoshi Tamura, Shizuoka
Leander Tryphonas, Ontario
Tetsuya Tsukamoto, Aichi
Masahiro Tsutsumi, Nara
Klaus Weber, Itingen
Midori Yoshida, Tokyo
Naomi Yoshimi, Okinawa
Katsuhiko Yoshizawa, Osaka

Description
The Journal of Toxicologic Pathology is an official periodical journal of the Japanese Society of Toxicologic Pathology. The journal
accepts original papers, short communications, case reports and review articles. One volume published each year is composed of fournumbers. Members of the Society are entitled to receive all publications in exchange for his or her membership fee. All articles
published in the Journal of Toxicologic Pathology represent the opinion(s) of the authors(s) and should not be construed to reflect theopinion of the Society.
The Journal of Toxicologic Pathology has been selected for coverage in Thomson Reuters products and services. Beginning withvolume 21, number 1, year 2008, the journal is indexed and abstracted in:◆ Science Citation Index Expanded (also known as SciSearch®)◆ Journal Citation Reports/Science Edition◆ Biological Abstracts◆ BIOSIS Previews
Mailing address: Dai Nakae, M.D., Ph.D., Editor-in-Chief
Editorial Office, Journal of Toxicologic Pathology, c/o Publication Center, IPEC, Inc., 1-24-12 Sugamo, Toshima,
Tokyo 170-0002, Japan
Journal of Toxicologic Pathology homepage: http://www.japantoxpath.org/en/publication/jtp/
Free access to full papers ofVols.1(1988)–10(1997): http://www.journalarchive.jst.go.jp/english/jnltop_en.php?cdjournal=tox1988
Vol. 11 (1998) or later: http://www.jstage.jst.go.jp/browse/tox/-char/en
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Online ISSN 1881-915X
Cover: 1) Histology of nephrogenesis in a neonate on day 1. Developing renal tubules (arrows) and maturing glomeruli (arrowhead) arepresent. HE stain. Bar=100 μm. 2) Immunohistochemical findings for cyclooxygenase (COX)-2 in fetuses on gestation days (GDs)
18 (A) and 21 (B). COX-2 expressions are observed in developing renal tubules (arrowhead) and S-shaped bodies (arrow, A) on
GD18 and in the macula densa (arrowhead) of juxtamedullary nephrons on GD 21 (B). Immunohistochemical staining, counterstained with hematoxylin. Bar=100 μm. 3) Immunohistochemical findings for microsomal PGE2 synthetase (mPGES)-1 in a neonate on day 1. Expressions of mPGES-1 are observed in the developing tubules (arrowheads), but not in S-shaped bodies (inset:
Bar=20 μm). Immunohistochemical staining, counterstained with hematoxylin. Bar=100 μm. 4) Immunohistochemical findings for
PGE2 receptor (EP) 4 in a fetus on GD 18. EP4 expressions are observed in the developing renal tubules (arrowheads) and S-shaped
bodies (arrow), as well as occasional interstitial mesenchymal cells. Immunohistochemical staining, counterstained with hematoxylin. Bar=100 μm. 5) Immunohistochemical findings for cyclin D1 in a neonate on day 1. Cyclin D1 expressions are observed in boththe nucleus and cytoplasm of the developing renal tubule (arrowheads) and S-shaped bodies (arrow), as well as mesenchymal cells.
Immunohistochemical staining, counterstained with hematoxylin. Bar=100 μm. (See Yamamoto E, et al., p. 257–261)