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Product Name : Creatine amidinohydrolase (CRH-211)

First issue : Sep. 1, 2014
Revised: May. 31. 2022
SDS No.864F

Safety Data Sheet
1 Chemical Product and Company Identification
Identification of the productProduct CodeSupplier
NameAddress

Creatine amidinohydrolase
CRH-211TOYOBO CO.,LTD.
Osaka Umeda Twin Towers South,
1-13-1 Umeda Kita-ku, Osaka 530-0001, Japan

Department

Biotechnology Overseas Sales and Marketing Department

Phone
Fax

+81-6-6348-3846+81-6-6348-3833
diagnostic product

Recommended use and restrictions on use

2 Hazard Identification

34

Most Important Hazards and Effects

The product might cause allergic reactions uponinhaling or skin contact because of the protein
contained.

GHS classification

Classification not possible

Composition/Information on Ingredients
Substance/Mixture
Chemical Nature
CAS#
Chemical specificity
Concentration or concentration range

MixtureCreatine amidinohydrolase
37340-58-2Freeze and drying powder including enzyme
ca. 56%(W/W)

Stabilizer, etc
Ingredients Contributing to the Hazard

ca. 44%The ingredients known as hazardous are not included.

First Aid Measures
Inhalation
Skin Contact

Remove to fresh air. Consult a physician whenunpleasantness occurs.
Wash off with plenty of water. Consult a physician when
inflammation on the skin occurs.

Eye Contact

Rinse cautiously with water for several minutes. Remove
contact lenses,if present and easy to do. Continue
rinsing.

Ingestion

Rinse mouth. Swill plentiful amount of water or milk for
immediate vomiting. Consult a physician.

5 Fire Fighting Measures
Specific extinguishing methods
Precautions for fire-fighters

Water spray,dry chemical powder,or carbon dioxide etc.
Firefighter should work from the windward side.

6 Accidental Release Measures
Personal Precautions, protective equipment
and emergency procedure.
Environmental Precautions
Methods and materials for containment andcleaning up.

Wear protective gear to avoid eye/skin contact andinhalation. Do not work at leeward.
High concentrated waste fluid should not be directly
discharged into rivers.
Take up under vacuum using dust collecting filter, wash
residual spill with copious amounts of water. Use
cloth, paper or anything similar to soak up thesolution leaking out of the container.
(Waste water should be treated with activated sludge oradsorbed with activated carbon etc.)

2/3Product Name : Creatine amidinohydrolase (CRH-211)

First issue : Sep. 1, 2014
Revised: May. 31. 2022
SDS No.864F

Safety Data Sheet
7 Handling and Storage
Handling
Technical Measures
Precautions

Wear protective gear to avoid eye/skin contact andinhalation.
Do not drop the container to prevent the content poppingout.

StorageTechnical Measures
Incompatible substances and mixtures
Storage Conditions
Packaging Materials

Keep sealed container in freezer.
None specified.
Store under -20℃ to avoid deactivating.
Use the initial container of the product.

8 Exposure Controls/Personal Protection
Engineering controls
Occupational exposure limit,biological limit
Personal Protective Equipment
Respiratory Protection
Hand Protection
Eye Protection
Skin and Body Protection

Provide shower and eye washing apparatus nearby.
Not applicable.
Protecting mask
Protecting gloves
Safety goggles
Long sleeve working wear

9 Physical and Chemical Properties
Physical State, form and colorOdour
pH
Flash Point
Explosiveness
Density
Solubility

Powder / White
No odourca. pH 6.0 (1% W/V)
No information available.
No information available.
No information available.
Freely soluble in water.

10 Stability and Reactivity
Stable at temperatures below -20℃.When left for long at
Possible hazard reactions at room temperature,proteins might be degraded, which does
not cause any hazardous reaction.
specific condition
StabilityConditions to avoid
Materials to avoid
Hazardous Decomposition Products

Prolonged storage under higher temperature than room
temperature and high humidity.
May react with strong oxidizing compound.
No information available.

11 Toxicological Information
Acute Toxicity
Skin corrosion/irritation
Eye damage/irritation
Sensitization

No information available.
No information available.
No information available.
Might cause allergic reactions upon inhaling or skincontact because of the protein contained.

Germ cell mutagenicity
Carcinogenicity
Toxic to reproduction
Specific target organ toxicity(Single exposure)Specific target organ systemic toxicity(Repeated exposure)
Aspiration toxicity

No information available.
No information available.
No information available.
No information available.

12 Ecological Information

No information available.
No information available.

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Product Name : Creatine amidinohydrolase (CRH-211)

First issue : Sep. 1, 2014
Revised: May. 31. 2022
SDS No.864F

Safety Data Sheet
Persistence/Degradability

This product is biodegradable and does not remain on theenvironment for long.

13 Disposal Considerations
Residues
A pollution container and packing

Dispose of in accordance with all applicable local andWash with copious amounts of water and waste conforming
to local regulations depending on the type of thematerial.

14 Transport Information
International regulations
IMO information
IATA information
Domestic regulations
Rail and road transportation information
Marine transportation information
Aviation transportation information
Specific precautions transport measures andconditions

Not applicableNot applicableNot applicableNot applicableNot applicable
Avoid direct sunshine and check the container and loading
to prevent leakage or turnover,fall and damage.Transportin accordance with regulations.Do not load with foods andfeed. Keep at temperatures below -20℃.

15 Regulatory Information
Regulations

Follow all of laws and regulations in your country.

16 Other Information
Notice

The information shall not be taken as being all inclusive
and is to be used only a guide.All materials and mixtures
may be present unknown hazards and should be used withcaution.The SDS is subject to revision as new information
becomes available.The information in this SDS,to the bestof our knowledge, is accurate and correct. However,TOYOBO
makes no warranty and assumes no liability whatsoever inconnection with any use of this information.