CONFIDENTIAL

Safe

ient
d
e
r
Ing
d
e
v
i
r
ells
y De
h
l
l
S
a
r
allop
Natu
c
S
100%

& Re
liabl

e, Fo

od R

evol
ution

!

Proposal for Calcined Shell Calcium
PANACEA FXPANACEA INC.

2016

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Concept●Concept

Safe & Reliable, Food Revolution!

Retains Freshness!
Prolongs Shelf-life!

Removes Pesticides& Wax Residue!

Eliminates
Bacteria & Viruses!

Copyright © 2016 PANACEA. INC., All Rights Reserved.

What is PANACEA FX?
【Word Origin】
The word “Panacea” is an ancient Greek word that means a “cure-all” and “a solution
for all difﬁculties.” FX is a coined acronym for “FOOD” and “EXCELLENCE.”

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Product Lineup

120 gHandy SizeFor use in households.

1 kg
Large 1 kg Size
Wide range of uses fromhouseholds to businesses.

10 kg
For Professional Use
Perfect for use in large quantities.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Special Features of Panacea®FX

Soak food in 0.1% solution for 3 〜 5 min. to disinfect,
prevent spoiling and remove pesticide❶ Disinfecting Effects

Effective in killing E. coli O157, Campylobacter, Salmonella, Staphylococcus aureus, Enterococcus,
Serratia, Vibrio parahaemolyticus, Pseudomonas aeruginosa, Pseudomonas ﬂuorescens, etc.

❷ Removes Fruit Wax

Removes wax coating on fruits such as apples and oranges. Eating fruits whole with the skinbecomes much safer.

❸ Removes Preservatives
from Food Surfaces

Because of its effectiveness in removing putrefactive bacteria and other bacteria, it is also highly
useful in retaining the freshness of food (much more effective compared to food preservatives).
Since it lowers the level of Redox Potential, it is useful in preventing oxidation of food.

❹ Removes Agricultural
Chemicals

Helps in removing agricultural chemicals from the surface of fruits and vegetables.

❺ Removes Chemical
Fertilizers

Removes chemicals such as nitrate nitrogen, which are hazardous to the human body.

❻ Preserves Freshness ofFood

Effective in prolonging the shelf-life of fruits and vegetables and also in eliminating harsh ﬂavors.

❼ Safe - Made from Natural
Ingredients

Panacea®FX is made from 100% natural ingredients - shells found in the nutrient rich deep sea of the
Hokkaido and Tohoku regions - which is made into a ﬁne powder by using a special method of heating
to over 1,000℃.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

PANACEA FX ‒ Effects / Instructions
When dissolved into water, it becomes a strong alkaline electrolyte (alkaline ionized water) with a pH value of approx. 13.
The alkalinity removes pesticide and wax residues and kills unwanted bacteria found on the surface of your food.

Add 1 g of PANACEA FX to 1 L of water to make a solution.
Soak food in the solution for about 3~5 minutes.

after
3~5 minutes

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Antibacterial Effects (E. coli/ Staphylococcus aureus/ Salmonella)

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Antibacterial Effects(E. coli/ Staphylococcus aureus/ Salmonella/ Tinea fungus / Streptococcus mutans/ MRSA)

Antibacterial testing was performed on E. coli, Staphylococcus aureus, salmonella, tinea fungus, Streptococcus mutans and MRSA.
Antibacterial effects were observed in each test, and immediate effects were found in all tests except for MRSA.

vi ability

100
80
60
40

Mean

した。この培地は、生理食塩水 100ml にホタテ貝殻セラ
ミックス 1g を入れ、約 24 時間攪拌した。これを、東洋
ろ紙 No.5C でろ過し、ろ過した溶液を使用した。水虫菌の抗菌試験には、次の 3 種類の菌を用いた。① 白癬菌( Arthroderma vanbreuseghemii )、 ②
白 癬 菌 (
Arthroderma benhamiae)、 ③ 酵 母 菌 (Saccharomyces
cerevisiae)である。酵母菌は比較のために実験を行った。
ミュータンス菌の抗菌試験は、試験液 0.9ml に培養したミュータンス菌 0.1ml を入れ、30 ℃の水槽で保温した。
これを 48 時間後に取り出し、抗菌性を確認した。

20( a)生理食塩水

005Incubation( b) ホタテ貝殻セラミックス
水溶液添加

10

time（ mi n）

図4

水虫菌の抗菌試験結果、48 時間後

図１ホタテ貝殻セラミックス水溶液添加の場合の大腸菌

2.4 MRSA の抗菌試験の生菌率

MRSA の抗菌試験に用いた菌は、メチシリン耐性黄色ブドウ球菌の臨床分離株 2 種類(No.60905,No.951121)である。 実験に用いた試験液は、ホタテ貝殻セラミックス
を生理食塩水に溶かしたものを用いた。なお、ホタテ貝
殻セラミックスの主成分は Ca(OH)2 であり、この水溶液の pH は 12.7 である。実験に用いた試験液の組成は、水溶液：培養した細菌＝ 0.9ml：0.1ml で行い、これを 30℃で保温し経過時間ごとに各生菌数を計測した。なお、
生理食塩水の場合は細菌に対し負荷を加えない場合の値として計測し、生理食塩水 0 分の生菌数を 100%として各生菌率を求めた。MRSA 抗菌試験終了後、大腸菌を鑑別する培地により鑑別を行った。生理食塩水とホタテ貝
殻セラミックス水溶液の他、比較のため、同じ pH 値に調整した試薬の NaOH を添加した場合の抗菌試験も行った。ホタテ貝殻セラミックス水溶液と試薬 NaOH の希釈
度は、10 －３である。

( a)生理食塩水( b) ホタテ貝殻セラミックス
水溶液添加

図２大腸菌の抗菌試験結果、培養時間 5 分

3.2 サルモネラ菌の抗菌試験結果
サルモネラ菌の抗菌試験の結果を表 2、図 3 に示す。
大腸菌と黄色ブドウ球菌の結果と同様にホタテ貝殻セラ
ミックス水溶液は強い抗菌効果を示した。

３．結果および考察
表 2 サルモネラ菌の生菌率(%)
培

3.1 大腸菌と黄色ブドウ球菌の抗菌試験結果
大腸菌培養液にホタテ貝殻セラミックス水溶液を加えて培養し、生菌率を調べた結果を表 1 と図 1 に示す。濃度が高い場合は、１時間で生菌率がほぼ 10-4%以下となる
4)
結果を報告 したが、本実験においては、ホタテ貝殻セ
ラミックス水溶液を加えた瞬間に、生菌率、35%(大腸菌)
52%(黄色ブドウ球菌)となり、約 1 分で生菌率がほぼ 0.4～ 0.5%の強力な抗菌結果を得ている(図 2)。この水溶液は強アルカリ性( pH12.7)であるが、この水溶液を中和した培養液中でも、即効性は落ちるものの 36 時間後に生菌率は 5%に達した。

養

液

0min

1min

5min

生 理 食 塩 水

100

-

-

-

ホタテ貝殻セラミックス

22

<10-2

<10-4

<10-4

（① Arthroderma vanbreuseghemii、 ② Arthroderma
benhamiae）は菌が生えず、抗菌効果がある。
ミュータンス菌は他の細菌に比べ、繁殖が遅く、死滅しやすい細菌であるため、今回の実験では、生菌率の計
測はできなかった。しかし、試験管での実験結果、 1 時
間後にミュータンス菌の沈殿現象が確認された。これは、ホタテ貝殻セラミックス水溶液により細菌が死滅したときに見られる特徴的な現象であり、大腸菌や黄色ブドウ球菌などでは確認している。そのため、今回の沈殿現象
もミュータンス菌が死滅しているものと判断でき、即効効果があると判断できる。
水虫菌の抗菌試験において、酵母菌に対しては影響がないようである。データが少なく、判断できないが、生体材料には、悪玉菌に対して抗菌作用があり、善玉菌に対しては影響がないと言うことが期待される。
3.4

MRSA の抗菌試験

メチシリン耐性黄色ブドウ球菌の抗菌試験結果を図 5と表 3 に示す。ホタテ貝殻セラミックス水溶液を培養液に添加した場合(60905)、培養時間 5 分で、生菌率 7.9%、

10min(b) ホタテ貝殻セラミックス(a)生理食塩水

水溶液添加の場合，15 分の培養試験
図5(a)生理食塩水

表１大腸菌と黄色ブドウ球菌の生菌率(%)( b)

ホタテ貝殻セラミックス

メチシリン耐性黄色ブドウ球菌(MRSA,No.60905)の抗菌試験結果

水溶液添加
図3

供 試 菌

0 min

1 min

5 min

10 min

大腸菌

36

0.4

-3

<10

-4

<10

黄色ブドウ球菌

62

0.6

<10

-4

<10

サルモネラ菌の抗菌試験結果、培養時間 5 分

3.3 水虫菌とミュータンス菌の抗菌試験

表 3 メチシリン耐性黄色ブドウ球菌の培養時間(min)と生菌率(%)の結果
供試菌-4

図4 (a)， (b)に培養試験終了後( 48 時間 )の写真を示す。実験の結果 、「ホタテ貝殻セラミックス水溶液添加のマルツエキス寒天平板培地」の場合、 2 種類の白癬菌- 118 -

大腸菌
黄色ブドウ球菌MRSA(60905)

培養時間(min)
0

1

5

10

15

30

36

0.4

<10-3

<10-4

－

－

0.6

-4

-4

－

62
59

44

<10

7.9

<10

0.7

<10

-2

15 分で 10-2%未満、30 分で 10-4%未満の結果を得た。同
じ pH12.7 に調整した試薬の NaOH 添加の場合は、30分で 10-2%未満となり、抗菌作用を示すが、ホタテ貝殻
セラミックス水溶液ほどの即効性はなく、単なるアルカ
リ性が影響しているだけではないことがわかる。
アルカリ水溶液中での抗菌機構として、細胞内への栄養の取り込み (物質透過 )の理論がある。細胞内からプロトン (H+)を排出し、これを再び細胞内に取り込むときにア
ミノ酸等の栄養素を取り込むが、水溶液中に(OH-)基が存在することにより、プロトン(H+)は反応し、水(H2O)になるために栄養素を取り込むことが不可能になり死滅する機構である。しかし、ホタテ貝殻セラミックス水溶液を中和した場合、即効性は劣るものの抗菌機能は見られ、単なるアルカリ性だけが影響しているのではないことが
わかる。
４．まとめ
ホタテ貝殻セラミックスの大腸菌、黄色ブドウ球菌、サルモネラ菌、水虫菌、ミュータンス菌、MRSA に対する抗菌試験を行った。いずれも、抗菌効果を示し、MRSA
以外は、即効性があると判断できる。
大腸菌等に対する抗菌効果の即効性の結果から、野菜、卵、台所用品を洗浄する自然素材で人体に優しい洗浄剤、「チャフクリーン」を実用化した。さらに、スポンジ、ファンなどの除菌、消臭に使用できる。この洗浄剤はホ
タテ貝殻セラミックスを主成分とし、100%天然素材である。ある食品メーカーの製品のカルシュウム添加剤としてホタテ貝殻が使用されているように、口の中に入っても安全な洗浄剤である。また、化学物質軽減・分解、消臭、防虫機能を併せ持つ洗浄剤である。また、水溶液として、種々のものにスプレーすることにより、応用範囲は広がる。例えば、カーペットの消臭、家具やカーテンに施し、室内の化学物質軽減、シックハウス対策の住居改善のためのリフォームとしても幅広く使用できる。
水虫菌に対する抗菌効果の結果から、水虫治療薬開発のための臨床試験が、2002 年 7 月より、病院にて臨床試験が行われ、 2 年後に治療薬が実用化される見込みである。MRSA 対策の洗浄剤も実用化のための技術開発が行われており、治療薬に関しては米国の薬品企業において技術開発が進行中である。
ホタテ貝殻の機能性を応用した研究開発は、人間の健
康と安全の確保につながり、持に、MRSA に対しては、解決不可能とされている問題を解決する可能性がある。
さらに、東北、北海道で産出される年間約 21 万トンの貝殻の廃棄物処理問題も解決が迫られている問題であり、製品開発の結果として、未利用資源の廃棄物を資源化し、高度利用循環型技術開発となり、地域活性化と産業の育5)
成と雇用創出が可能である 。

－
<10-4

- 119 -

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Testing of the Effects of Panacea®FX on Food ①
1: Bean Sprouts (0.1% Panacea®FX Solution)*Tokyo Metropolitan Food Technology Research Center・Mold Growthless then 1%

・Germination Rate

99%

・Hypocotyl Length

272mm

The growth and harvest of bean sprouts
increased. The calcium and mineral content
increased. Achieved even hypocotyl length andimproved in crispness.
Harmless: healthy and safe.

2: Sliced Cucumber Disinfecting Test (0.1% Panacea®FX Solution)*National Food Research Institute・Immersion Time

5 min.

・Common Bacteria

2.8 x 105 → 680

・E. coli880→ Negative

Prevents odor and discoloring.
Retains crispness.
Prolongs freshness and shelf-life.

3: Shredded Cabbage Disinfecting Test (0.1% Panacea®FX Solution)*National Food Research Institute・Immersion Time

5 min.

・Common Bacteria

1.3 x 105 → 200

・E. coli70→ Negative

Disinfects, prevents molds and retains
freshness of packaged vegetables, by using
Panacea®FX during the cleansing process.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Testing of the Effects of Panacea®FX on Food ②
4: Chinese Noodles Disinfecting Test *Panacea®FX used as a replacement for Kansui
Type

Start

3rd Day

5th Day

7th Day

14th Day

Uncooked Noodles
w/ Kansui

2.53 x 103

2.74 x 103

1.49 x 103

5.06 x 103

1.79 x 103

Uncooked Noodles
w/ Panacea®FX

＜300

＜300

＜300

＜300

＜300

When made with Panacea®FX, the shelf-life of noodles can be prolonged while retaining their freshness.

5: Defrosted Squid Disinfecting Test *National Food Research Institute

Treatment

Bacteria

Common Bacteria

E. coli

Time

Start

24 Hours

48 Hours

Start

24 Hours

48 Hours

Tap Water

3.4 x 104

4.2 x 104

8.0 x 104

5.1 x 104

3.0 x 104

7.0 x 104

Panacea®FX

＜300

＜300

＜300

(ー)

(ー)

(ー)

6: Red Bean Paste Mold Inhibition Test (kept at a temperature of 25℃)
*National Food Research InstituteRed bean paste without PANACEA FXStartRed bean paste with PANACEA FX

StartMold found after 7 days
Mold found after 10 days・With the use of PANACEA FX, evidence of mold inhibition and syneresis prevention was found.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Testing of the Effects of Panacea®FX on Food ③
7: Red Bean Jelly Mold Inhibition Test * National Food Research InstituteRed bean jelly without PANACEA FXStartRed bean Jelly with PANACEA FX

StartMold found after 3 days
Mold found after 10 days

8: Raw Chicken Thigh Post-Treatment Observations(preserved at 5℃)*National Food Research Institute
Solution

Bacteria Type

1st Day

2nd Day

3rd Day

4th Day

5th Day

0.85% Common
Hypochlorous
Acid Solution

Common Bacteria

3.0 x 103

6.0 x 103

1.3 x 104

1.3 x 105

2.0 x 105

E. coli

7.0 x 101

7.9 x 102

2.1 x 103

2.7 x 103

3.6 x 103

Common Bacteria

＜300

＜300

＜300

＜300

＜300

E. coli

(ー)

(ー)

(ー)

(ー)

(ー)

0.5% Panacea®FX
Solution

9: Raw Chicken Thigh Post-Cooking Observations(preserved at 25℃)
*National Food Research Institute
Solution

Bacteria Type

Immediately After

1st Day

2nd Day

0.85% Common
Hypochlorous Acid
Solution

Common Bacteria＜300

2.5 x 104

1.4 x 107

E. coli

(ー)

(ー)

(ー)

0.5% Panacea®FX
Solution

Common Bacteria＜300

3.0 x 1033

1.0 x 1033

E. coli

(ー)

(ー)

(ー)

4

＊Also effective with beef, pork, roast beef, processed meat, etc.
＊Prolongs shelf-life, enhances juiciness, tenderizes meat, provides binding effects and prevents dripping.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

7

PANACEA FX Food Immersion Testing
Cherry Tomatoes
PANACEA FX solution removes
pesticide, wax and preservative
residue and eliminates the viruses
and bacteria found on the surfaceof the tomatoes, making them safeto eat while also enhancing theirﬂavor. After soaking the tomatoes
in the solution, the solution turns
yellow. This is because theoxidized polyphenol of thetomatoes reacts to the calcium ion
and the nitrogen found in the air.

Rice
The oxidized bran and starch of
the rice react to the alkali・calcium
ion, immediately changing the colorof the solution to yellow. Throughthis reaction, the residual
pesticides and preservatives are
removed from the rice. Stir therice for 10~15 seconds as you
would when cleaning, and thenfollow the usual process of rinsing
and cooking the rice. The rice will
become tastier with enhanced
ﬂufﬁness and springiness.

Tea Leaves
Briskly wash the tea leaves with
PANACEA FX solution for 5 seconds
and rinse with water. Any residue,
such as pesticides and wax, will be
removed from the leaves, bringing
out their natural ﬂavor and making
them tastier. As it is apparent in thephotos, with the effects of the alkaliions, the residue found on thesurface of the leaves is immediately
removed and dissolved. ※Be careful
not to soak the leaves in the solution
for more than 5 seconds.

PANACEA®FX Solution(0.1%)
Soaked for 5 minutes.

Tap Water
Soaked for 5 minutes.

PANACEA®FX Solution(0.1%)
Soaked for 10 seconds.

Tap Water
Soaked for 10 seconds.

Shiitake Mushrooms
Agricultural chemicals, pesticides,
preservatives and bacteria areremoved from the shiitake
mushrooms, regaining the aroma
and freshness. It is obvious to see
how much contamination can befound on imported shiitake
mushrooms.

Asari(Japanese Carpet Shell) Clams

PANACEA®FX Solution(0.1%)
Soaked for 5 minutes.

Tap Water
Soaked for 5 minutes.

PANACEA®FX Solution(0.1%)
Soaked for 2 hours.

Tap Water
Soaked for 2 hours.

PANACEA®FX Solution(0.1%)
Soaked for 10 minutes.

Tap Water
Soaked for 10 minutes.

Clean the clams by soaking them ina solution of water with 1 % salt and
0.1% of PANACEA®FX for 2 hours.
This will remove the viruses andbacteria found on the clams, which
will revive the freshness, making
them tastier and safer to eat.

PANACEA®FX Solution
Soaked for 5 seconds.

Tap Water
Soaked for 5 seconds.

Fish
By soaking ﬁsh in the PANACEA FX
0.1% solution for 10 minutes, they
become fresher and tastier after
the removal of viruses, bacteria andoxidized fat. They also keep theirshape even after grilling or boilingand wonʼt crumble or break aparteasily. By soaking in the solution
before refrigerating, the ﬁsh stay
fresh longer.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Rice Taste Analysis (Satake Rice Taste Analyzer)

Although the score given to the rice does not usually change very often, the rice washed for 10
seconds with PANACEA FX solution gained 3 whole points! It even scored 0.8 higher in the“stickiness” category.

By washing with PANACEA FX, pesticides and oxidized bran residue are removed from the rice.
This also accelerates the gelatinization, creating tasty rice that is ﬂuffy and springy.

Using Tap Water

Using PANACEA FX 0.1% Solution

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Reduction Effect of Panacea®FX on Pesticide Residue
In this pesticide reduction testing, a solution made with food additive, Panacea®FX, calcined scallop shells, was used to test its
effects on breaking down pesticides. As a result, a reduction (breakdown )of pesticide levels in vegetables was found. The main
ingredient of Panacea®FX is calcium oxide, which, when it reacts to water, produces a solution high in alkalinity. It is commonly known
that alkalinity has a breakdown effect especially on organic phosphorous based pesticides. Because many of the pesticides are
relatively insoluble, washing food with water alone will not remove most of the pesticides found on the surface of the food.
Therefore, having found proof of pesticide reduction when using this approved food additive, it can be conclude that Panacea®FX isa safe and effective product for pesticide removal.
①StartConcentration (unit:ppm)

Concentration Reduction Graph②10min of soaking

Methamidophos

Triazophos

Pirimiphos-methyl

Pesticide Types

Phosphamidon

Fosthiazate

EthionEPN

Chlorpyrifos-methyl

Chlorpyrifos③30min of soaking

Examined by Techno Science Co., Ltd Environmental Analysis Department
Has the power to breakdown 99% of even Methamidophos

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Effects on Radiation
機能性Voice of the Panacea®FX User

The effect of scallop shells in decontamination
has been reported by the Yomiuri Newspaper!!

I was impressed by your companyʼs powder (scallop
shells).
Originally, I bought this item to get rid of the body odor I
was experiencing, which comes with aging, and it wasvery effective.

"Scallop shells, which can be obtained cheaply even in thedisaster areas, have countless micro sized pores which
are said to be effective in absorbing radioactive cesium.

I saw on TV that the shell powder is used in experiments
for radiation decontamination.

Because it does not contain any chemical substances, it isalso environmentally friendly. Its ability to kill three birds

I live in Ichikawa-City, Chiba and the radiation level isquite high in my neighborhood.

with one stone is highly promising.
According to Hiroki Ohtani, associate professor of Tokyo

It shocked me to discover that the soil under the rain
gutter emitted 5.45 becquerel.

Metropolitan University and the creator of the study, themineral 'Zeolite' is microporous and is commonly used for

So I tried the powder on the soil right away. After waitingfor 2 weeks, the radiation

removing radioactive cesium. However, the number ofpores on the scallop shells exceeds that of zeolite, whichlevel was down to 0.715 becquerel.

he believes will be highly effective in absorbing cesium."

I am truly amazed by your product and wanted to reportyour productʼs impressive

Source: Yomiuri Newspaper

effect on radiation.
(comment received from Suwada, Ichikawa-City)

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Corrosion Control Testing / Mold & Die Cleaning Water Testing

Corrosion Control Testing
The nail immersed in 0.1% PANACEA® FX solution does not rust even after 3 months, while the nail immersed in tap watershows clear signs of oxidation progression as the water turns murky.

Tap Water PanaceaFX

Tap Water PanaceaFX

Die / Mold Machinery Cleaning Water Testing
When using underground water for cleaning molds and dies, the water became contaminated with pollutants and oil,producing bacteria and causing putrefactions, leading to the emission of malodor. With the use of PANACEA® FX, the odor
level was greatly reduced.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Food Additive Speciﬁcations and Standards Compliance Test
“PANACEA FX” is approved as a safe food additive by the Japanese government.
It is identiﬁed by the mark “PF.”Copyright © 2016 PANACEA. INC., All Rights Reserved.

Safety (LD50 Value ‒ Lethal Dose, 50%)

The LD50 is an abbreviation for median lethal dose. It is the amount of substance that causes thedeath of one half of a group of test animals (rats, guinea pigs, etc.) after a speciﬁed test duration.
The amount of substance required to kill 50% of the test population is expressed as the weight ofchemical administered per unit mass of test subject (mg/kg). It is often used as a generalindicator of a substanceʼs acute toxicity. The value of LD50 is calculated by creating a graph using
the test data on substance amount and the death rate of the test animals. 50% lethality waschosen as it was statistically reliable with less potential for making measurements in the extreme.
It is generally considered safe when the LD50 ﬁgure is over 1500mg/kg.

※PANACEA FX was observed to be signiﬁcantly safer than common salt inacute oral toxicity testing in rats.

LD50
PANACEA FX®

6,600mg / kg

Salt

4,000mg / kg

Sodium Hypochlorite

5mg / kg

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Uses and Effects of Panacea®FX（Fruits & Vegetables）
Fruits & Vegetables
Intended Use・For disinfecting, removing pesticides, wax and retaining freshness of food
Instructions
・Stir in 1g of Panacea®FX into 1L of water. Soak fruits and vegetables for 3〜5 min. Rinse with tap water. The solution
can be used consecutively up to 3 times.
・Place a strainer or other type of weight on top to keep fruit and vegetables completely submerged in the solution.
If not, use a bubbling device and stir. Make sure to let all surfaces of food soak in the solution, especially leafy vegetables.
・For dried beans, soak in 0.1% solution for 8 hours during summer and 12 hours during winter.
*A 0.3~0.5% concentration is sometimes preferred in commercial use.
(0.3%: To mix in the dough for pastas and other noodles / 0.5%: For cleaning large amount of vegetables)
Effects
・Depending on the oxidized level, green vegetables may or may not change color. However, the discoloration is not related to the disinfecting or
pesticide removal effects.
Compared to the general data of the effect of tap water on pesticide removal, the effect of Panacea®FX solution is 2.7 times higher.
・The alkalinity in the solution and the organic matter (polyphenol, etc.) in tomatoes react to each other and cause the solution to turn yellow.
This helps to disinfect, remove pesticide and retain freshness.
・The Panacea®FX solution helps in suppressing bioactivity in vegetables, which prevents the release of ethylene gas. This will keep food fresheven in room temperature. It also removes putrefactive bacteria and other germs from food and prevents oxidation by lowering the level ofRedox Potential.
・Useful in removing lye from wild vegetables with strong bitter taste. It enhances the natural taste of food.
・Highly effective in removing pesticide from parsley, grapes and broccoli.
・Its anti-bacterial effect on lettuce are equal to hypochlorous acid up to 2 days but surpasses the effects of hypochlorous acid beyond 2 days
・No molds or damages were found on blueberries after 12 days of refrigeration. Excellent results were reported in Organoleptic Testing and
Visual Inspection.
・The solution turns milky white because Panacea®FX reacts with the dirt, chemical fertilizer, endocrine disrupters, pesticide residue, etc. found on
food and with nitrogen in the air.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Uses and Effects of Panacea®FX (Beef/ Pork/ Poultry）
Beef/ Pork/ Poultry
Intended Use
For disinfecting and creating an anti-bacterial condition, preventing discoloring & retaining freshness.
Instructions＜Beef/ Pork/ Poultry＞
・Add 1g of Panacea®FX into 1L of water.
Submerge the meat completely and soak for 20 min.
Rinse with running water.
When using frozen meat, make sure to thaw out before the procedure.
・It is effective for all purposes (grilling, frying, stewing).
*When preparing large amounts of meat, use a 0.3~0.5% concentration.

＜Effects＞
・It enhances the ﬂavor of meat and tenderizes.
＜Q&A＞
Q：Wouldnʼt the meat lose its ﬂavor by soaking it in the solution?
A：It may seem hard to believe but the meat soaked in Panacea®FX solution actually becomes tastier.
With its deoxidizing power, it restores the ﬂavor of meat and makes it very tender.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Uses and Effects of Panacea®FX（Noodles）
Noodles
Intended Use and Effects
・By adding Panacea®FX, the initial bacterial count can be reduced and with the effect of pH control, retaining the freshness of noodles is possible.
It also enhances the springiness in noodles.
・It can be used to replace or reduce the amount of kansui (alkaline water) when making ramen noodles.
・The water left after boiling noodles becomes less mirky.
・Depending on the added amount, the noodles can be labeled as a “ Calcium-Enriched” product.
・After boiling or steaming, cool the noodles with 0.3% Panacea®FX solution to keep the noodles fresh and improve shine and silkiness.
・It can also be used for dim-sum wrappers and stufﬁng.
Instructions
・Make the solution for the dough by adding Panacea®FX (0.3% the amount of ﬂour) to water. Adjust the amount to achieve ideal springiness andcolor of the noodles and according to the amount of kansui (alkaline water) when using together.
・Make sure to create required amount of Panacea®FX solution to make dough. Mix the solution well with ﬂour. Panacea®FX can be directly
added to ﬂour but the powder needs to be distributed evenly.
※Add a little more Panacea®FX solution than the usual amount of water used when making dough. When making the solution, it isrecommended to use chilled water to achieve higher solubility and effects.
※By adding Panacea®FX, the noodlesʼ springiness, color and ﬁrmness changes. Adjust the time for kneading accordingly.
Precautions
・Test before using.
・As a general rule, avoid using Panacea®FX with a pH adjuster or other shelf-life prolonging agents. It may reduce the effects and cause odor
and discoloring.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Uses and Effects of Panacea®FX（Rice)Intended Use・For enhancing ﬂavor, preventing discoloration and removing odor from old rice.

Rice

Instructions and Effects
・Add Panacea®FX ＜1g per 3〜5 go of rice (1go = 180ml/150g)＞ and stir for about 10 sec. ( *1 longer than 10 sec. could cause discoloring).
If discoloring occurs, rinse thoroughly in a strainer. Wash rice as usual and cook.
・Freshly cooked rice will become tastier and even cold rice retains its deliciousness.
It decomposes and removes the cause of odor in old rice, oxidized gluten and fatty acids, and enhances the natural ﬂavor of rice.
＊1＊2

Soaking the rice in the solution for 1~10 minutes can enhance the ﬂufﬁness and springiness of the rice. Testing different soaking times isrecommended to achieve the desired result.
The discoloration of rice, turning yellow, is caused when the Panacea®FX reacts with gluten and fatty acids contained in rice. Factory washedrice does not often produce discoloring effects.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Uses and Effects of Panacea®FX (Seafood & Seaweed)
Seafood (ﬁsh/octopus/squid/shellﬁsh)
Intended Use・For disinfecting and creating an anti-bacterial condition, preventing discoloring, retaining freshness and preventing drip loss when frozen.
Instructions and Effects＜Fish/Octopus/Squid/Shrimp＞
・Stir 1 g of Panacea®FX into 1 L of 1% saline water. Soak seafood for 20 min. and rinse with tap water.
For refrigerating, refrigerate without rinsing with tap water to retain the freshness 2〜3 days longer.
(The total viable bacterial count of 300 and under after 2 days of refrigerating)・With the use of Calcine Calcium, it is possible to suppress the raw smell of seafood up to 5 days.
・Also effective with imported shrimp＜Shellﬁsh＞
・Soak clams in 0.1% Panacea®FX solution for 20 min. Remove dirt and scum ﬂoating in the water and rinse the clams before cooking.
・Can be used for preventing SRSV(Norovirus) in oysters.

SeaweedIntended Use・For disinfecting and creating an anti-bacterial condition and retaining freshness.
Instructions and Effects
・Soak dried or raw seaweed in 0.1% Panacea®FX solution for 5 min, drain and keep refrigerated.
Rinse out the solution before eating or cooking.
Typically, seaweed becomes slimy after 2〜3 days of storing but seaweed soaked in Panacea®FX solution retains its freshness up to 5〜6 days.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Retaining Freshness of Seafood for Commercial Use
Retaining Freshness of Seafood for Commercial Use
Present Condition
Generally, seafood is caught in ﬁshing boats, passed through ﬁsh markets and end up in places like factories where it is cleaned of dirt and other excesses
with tap water, seawater, a hydrogen peroxide solution or something akin to chlorine bleach.
However, this process is unable to suppress discoloration and the spread of germs and can only retain the freshness of seafood for a short period of time.
The Purpose of Using Panacea®FX
By putting the seafood through the process of freshness retention (by washing and icing) using Panacea®FX, its shelf-life, in raw and edible state, will be
extended by 1〜2 days longer.
With this, it is possible to reduce the amount of wasted seafood and cut expenses.
Instructions①Before shipping, the seafood is cleaned with seawater. Add 1g of Panacea®FX into 1L of the seawater (0.1% solution.) Shower the solution over seafood
or soak the seafood in the solution for 3〜５ min.
②After cleaning with Panacea®FX solution, pack the seafood with ice made from 0.1% Panacea®FX solution in the container. Once the Panacea®FX ice starts
to dissolve, compared to normal ice, it signiﬁcantly reduces the amount of germs and assists in retaining the freshness.
＜For Reference＞
The cost of the total amount of seafood wasted a month in Hachinohe Fishing Port amounts to over 100 million yen. By using Panacea®FX, this waste canbe reduced signiﬁcantly.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Uses and Effects of Panacea®FX（Sushi Restaurants & Salad Bars)[1]Sushi Restaurants & Salad Bars
Instructions and Effects
Concentration of Solution
・Use 0.1% or 0.3% solution according to purpose.
・Use 0.1% solution for soaking and 0.3% solution for spraying.
Shellﬁsh (clams and other shells)
・Soak them while alive in 0.1% solution for 2〜3 hours. Use saline water (10g of salt/ 1L of water) when making the solution. After the clams
expel all the dirt, rinse thoroughly and keep refrigerated in a show case or refrigerator.
・This will enhance the ﬂavor and prolong the freshness of cooked and raw clams.
・For frozen clams, spray the 0.3% solution evenly after thawing. The freshness can be prolonged even to the next day. Use any spray bottle
found in stores.
Fish and other SeafoodsSquid▶︎ Spray evenly.

Octopus▶︎ Soak boiled octopus for 10 min.

Mackerel, Kohada & Hamachi▶︎ Fillet in 3 pieces and spray evenly.

Tuna ▶︎ Spray the tuna in ﬁllet size.
Uni (sea urchin)▶︎ Gently soak in 0.1% solution made with saline water for 5 min.

Tai (sea bream), Aji (horse mackerel) & Salmon▶︎ Fillet in 3 pieces and spray evenly.

Shrimp ▶︎ Soak raw shrimp in 0.1% solution made with saline water for 5 min. Spray for boiled shrimp.
Flounder ▶︎ Spray.
Seaweed▶︎ Soak in 1% solution for 5 min. Drain well and refrigerate. Highly effective in inhibiting germs.

Tuma (shredded radish) ▶︎ Soak shredded daikon (Japanese radish) for 5 min. Rinse and drain well. Wrap and store in refrigerator.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Uses and Effects of Panacea®FX（Sushi Restaurants & Salad Bars)[2]Sushi Restaurants & Salad Bars
Salad
・Soak cut vegetables for 3〜5 min. Rinse and drain well. Wrap and store in refrigerator.
Important Points
・After spraying or soaking ﬁsh and vegetables, make sure to drain and wrap them in plastic wrap to prevent drying out.
・Be cautious of any dripping.
・Use chilled water or tap water. Do not use lukewarm water.
・Make sure the food is completely submerged in the solution. Do not allow the food to ﬂoat.
・By spraying or soaking, inhibition of germs can be achieved and it is possible to prolong the shelf-life by 2〜3 days. However, to ensure safety,
shelf-life should be considered to be extended by only 1 day.
◎ Do not reuse the solution after 24 hours of ﬁrst use.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Uses and Effects of Panacea®FX (Others)

Omelets

Add 4cc(4ml) of 0.1% PANACEA®FX solution for 2 eggs (small/medium).
and reduces food poisoning bacteria.

Boiling/Stewing

Soak cut ingredients (meat, vegetables, etc.) in 0.1% solution for 20 min. and rinse. Helps tokeep food intact and brings out its natural ﬂavor.

Sushi Toppings

Spray 0.1% solution on to sushi toppings.
day longer.

Pickles

Soak ingredients in 0.1% solution for 5 min. Not only does it disinfect but also enhances
crunchiness and color and helps to preserve longer.

SaladsSoak in 0.1% solution for 5 min. Disinfects and prevents discoloring (more effective thanhypochlorous acid) and helps to preserve longer.

Processed Meats

Helps in prolonging the standard value of the antibacterial effect 2 days longer than whenusing sorbic acid.

Dish Washing

Cleans and disinfects dishes, cutting boards and baby bottles by soaking them in 0.1%
solution.

Tofu Production

Helps in producing more soy milk and helps tofu to last longer.

Enhances texture

Disinfects, reduces odor and retains freshness 1

Copyright © 2016 PANACEA. INC., All Rights Reserved.

For Use in Laundry
機能性For your laundry…
While many people use sodium bicarbonate (baking soda) for washing clothes, PANACEA FX is much more effective, as it has astronger alkalinity. It is useful for eliminating the damp odor often found when drying clothes indoors.

Instructions
Add PANACEA FX (3~5 g / 1~2 tablespoons for 20 L of water) with clothes and detergent and proceed with the usual process of
washing clothes.
★The alkalinity of PANACEA FX enhances the cleansing effects of laundry detergent. Less detergent than usual is needed toachieve the effective results, contributing to a reduction in the amount of detergent used.
★Alkalinity is still effective even at a water temperature of 20~30℃. Boiling water is not necessary to achieve higher cleaning
effects.

Effects
・Strong alkalinity enhances the effects of laundry detergent.
・Eliminates damp odor / disinfecting effects of strong alkalinity / prevents yellowing caused by rust and other factors /removes black mold found inside the washing machine.
・Disinfects trichophton fungus (ringworm), E. coli. etc. / removes slime and malodor from water pipes and drains.
※It does not have any bleaching effect. It is not effective when used together with chlorine bleach.
※Can also be used in fully automatic washing & drying machines and in dry cleaning.
※Occasionally a white powder may be left on clothes, which is calcium and is harmless.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

For Disinfecting Kitchenware! Deodorizing! And Much More![1]機能性For Disinfecting Kitchenware and Preventing Food Poisoning…
Adding PANACEA FX in water creates strong alkaline water. This alkaline water has antibacterial and disinfecting effects(bacteria can not grow in alkaline water). It is effective to use PANACEA FX solution on cookware such as cutting boards,
dishcloths and sponges and also for cleaning sinks and ﬂoors.

Instructions
Create strong alkaline water by adding 1~1.5 tablespoons of PANACEA FX in 20 L of water. Use to wash cookware.
★Although there are other antibacterial spray products that use alkaline water, about 1.5~2 tons of alkaline water can beproduced with only 1 kg of PANACEA FX.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

For Disinfecting Kitchenware! Deodorizing! And Much More![2]機能性Deodorizing Effect・ Spraying alkaline water (made from PanaceaFX) onto curtains, carpets, inside shoe racks and around entrances will help toeliminate odors.
※ Use with caution when spraying on dark colored material and shoes as it may leave white powdery residue after drying.
※ The white residue found in the bottom of the container is calcium and is harmless.

For Other Use
・Drain openings and other places that produce odors!
※PANACEA FX does not have the ability to dissolve hair.
・For kitchen ﬂoors and drains※Immediate effects may not be achieved, depending on the condition of the place and the strength of odor.
The odor can be reduced with the continual use of PANACEA FX.
・Washing feet in a basin full of alkaline water can help to eliminate odor (about 2 g of PANACEA FX in 2 L of water).
Calcined shell calcium is classiﬁed as a food additive by the government of Japan (Ministry of Health, Labour and Health
Notiﬁcation No. 120 Food Additive under the Food Sanitation Act 128). It is a calcined and powdered shell, which is additivefree and pure clacined calcium that is approved by the government as a safe and natural food additive.
When using this product, please follow the instructions and use the speciﬁed amounts.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Panacea®FX Users①Disinfects and retains freshness of vegetables such as lettuce, cucumbers and cabbage. Received well
Cut Vegetables Manufacturer

for their enhanced ﬂavor.

Supplies to major convenient stores②Assists in enhancing ﬂavor of Tsuma, shredded Japanese radish served next to sashimi, andretaining its freshness longer than using hypochlorous acid.

Cut Fruits Manufacturer
Supplies to major supermarkets and convenient
storesCan be used for all cut fruits such as strawberries and pineapples. Drastically extends shelf life ofstrawberries.
Replacing sorbic acids with Panacea®FX made it possible to supply their products to major

Processed Meat Manufacturer

supermarkets.

Helps in retaining freshness of seafood commonly found in the ocean near Japan like Aji (Horse

Fish Market

Mackerel), Saba (Chub Mackerel), squid, wakame seaweed and frozen ﬁsh.

Fishing port in Fukuoka

Helps to prolong the freshness of sashimi up to 4〜5 days, which usually lasts only 2 days.

Mill Factory
Used in ﬂour for making bread, pizza, etc.

Prevents food poisoning, enhances ﬂavor, improves the look of products and supplements calcium.

Ice Manufacturer

Ice made from Strong Alkaline Water with a pH value of 12 aids in retaining freshness of ﬁsh.

Used in ice for ﬁsh markets

Enables the production of edible ice with a pH value of around 9〜10.

Noodle Manufacturer

Perfect for retaining the freshness of noodles. Lasts 2〜3 days longer when refrigerated.

Used in more restaurants

Washed Rice/Bento Lunch Manufacturer①Prevents decay. Rice regains its newly harvested freshness.

Used in Bento lunches②Rice stays delicious even when itʼs cold.

Dried Wakame Seaweed Manufacturer
Supplies to supermarket as seaweed salad

The usual 2〜3 day shelf life of dried seaweeds can be doubled when soaked in Panacea®FX solution.

General Food Service Industries

Enables raw meat, ﬁsh and vegetables to retain freshness and helps to signiﬁcantly reduce waste

Used in ﬁsh/meat/vegetables

and expenses.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

The Mechanisms of PANACEA FXDisinfecting/ Cleansing/ Deodorizing/ Retaining Freshness / Improving Taste

PANACEA®FX
Ingredient: 100% Scallop Shells
Burning Temperature: 1,200℃→pH13.2＊Generally: 700℃→pH 12
LD 50 approx. 400 g / 60 kg

Food<vegetables / fruits / rice /ﬁsh / meat / etc.>

pesticide / wax / dirt
/ hormone mimicking
chemicals / etc.

Food becomes safe
and worry-free

Improves Taste.
Tastier food that is
crisper and ﬁrmer.

Exfoliated and removed
with effects of strong
alkalinity

Hydroxide ions help to
extract umami
components (aminoacid and glutamic acid /speeds up
sacchariﬁcation(conversion to sugar) /gelatinization of
starch / water
absorption / increases
mineralsumami (ﬂavor)
component &mineral component

PANACEA®FX Solution（0.1%〜0.5%）
Alkaline Ionized-Reduced Water pH13.2
Oxidation-Reduction Potential -200 mV~-400 mV* Tap Water 400 mV~500 mV
Overwhelming amount ofhydroxide ions (OH-) and hydrogen ions (H+)

Viruses & Bacteria
Norovirus / E. coli /Salmonella / etc.

putrefactive
bacteria / anaerobic
bacteria / bacteriathat causes discoloringof food stored inrefrigerators*

odor & oxidative
component

PANACEA®FX Food Revolution
Tastier food that is safe and worry-freewith long lasting freshness.

Disinfects food(surface /inside) withthe effects of strong
alkalinity (pH13.2)
Viruses and bacteria
undergo hydrolysis withthe effects ofhydroxide ions (OH-)

・Same as above. Food
becomes less prone tooxidation.
*Pseudomonas
ﬂuorescensWith the effects of H+& OH-, odor andoxidative components
become odorlesscompounds

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Disinfects while
inhibiting the growthof viruses andbacteria

Controls theoxidation in food /retains freshness

Eliminates odors infoodSummary“Calcined Scallop Shell Powder PANACEA FX” is all-natural, made of 100% scallop shell. Calcium
hydroxide, created by calcinating the shells at a temperature of over 1,200℃, has excellent
disinfecting and cleansing powers and is also highly effective on odors such as putrid odor andammonia.
As the ingredient is 100% natural, PANACEA FX is safe and reliable. The solution made with
PANACEA FX can be sprayed directly onto food. Food can be disinfected and retains its
freshness, when soaked in the solution.
The basic use of PANACEA FX is for soaking food. The solution can be created by adding 1 g of
the PANACEA FX into 1 L of water. By soaking food in this solution for about 5 minutes, you caneliminate pesticide residue, preservatives, waxes, chemical fertilizers and coliform group bacteria
and as a byproduct, it can also help to retain freshness and prolong shelf life of food. Vegetables
will become crisper and rice will become ﬂufﬁer and springier, bringing out the natural ﬂavor andtexture of food.
With just 1 bottle of PANACEA FX, food can become tastier and stay fresh longer and by using it inyour kitchen, you can obtain a safer, worry-free and clean environment.
We are conﬁdent of PANACEA®FXʼs potential as a product that will be widely sought after, not only
domestically but also in Mainland China, Hong Kong, Taiwan, Singapore and in other East Asian
countries.

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Product Flyer

Copyright © 2016 PANACEA. INC., All Rights Reserved.

Lastly…

We thank you forconsidering PANACEA FX.

Copyright © 2016 PANACEA. INC., All Rights Reserved.