PRINCESS TAKAMATSU CANCER RESEARCH FUND
PRINCESS TAKAMATSU CANCER RESEARCH FUND PRIZES

1st (1968)

Masaru Kuru
Studies of Premalignant Changes in Gastric Cancer
Waro Nakahara
Discovery of Toxohormone and a Carcinogenic Property of 4-nitroquinoline
N-oxide2nd (1969)

Takashi Sugimura
Experimental Induction of Gastric Cancer

3rd (1970)

Takeo Kakunaga, Juntaro Kamahora, Toshio Kuroki and Haruo Sato
In vitro Carcinogenesis in Hamster Cells Using 4-nitroquinoline N-oxide
Mitsuru Furusawa, Motoo Hozumi, Yasuo Ichikawa, Yoji Ikawa and Haruo Sugano
Redifferentiation of Leukemia Cells

4th (1974)
5th (1975)

Hiroto Shimojo and Kumao Toyoshima
Analysis of the Carcinogenesis of Mutant Strains of Tumor Virus

6th (1976)

Sajiro Makino
Chromosome Analysis and Cancer Cells
Hamao Umezawa
Secondary Metabolites of Microorganisms and Cancer

7th (1977)

Hiroshi Hasegawa
Surgery for Hepatic Carcinoma

8th (1978)

Yuichi Yamamura
Biochemistry of Cancer Hosts and Cell Interactions

9th (1979)

Shigeto Ikeda
Development of the Bronchoscope for Lung Cancer
Yorio Hinuma and Shiro KatoHerpes Virus and Cancer

10th (1980) Iwao Hirono, Takashi Kawachi, Taijiro Matsushima, Minako Nagao, Shigeyoshi
Odashima and Shozo Takayama
Naturally Occurring Carcinogens
11th (1981) Hirota Fujiki and Sohei Kondo
Initiators and Promoters in Carcinogenesis
12th (1982) Ryo Sato
Discovery of Cytochrome P-450
Ryuichi Kato
Pharmacology and Cytochrome P-450
13th (1983) Yorio Hinuma, Isao Miyoshi, Kiyoshi Takatsuki and Mitsuaki Yoshida
Etiology and Molecular Biology of Adalt T-cell Leukemia
14th (1984) Yoshiyuki Hashimoto, Nobuyuki Ito, Tadao Kakizoe, Masashi Okada and Osamu
YoshidaExperimental Bladder Cancer

15th (1985) Yukio Shimosato
Pathology and Biology of Human Lung Cancer
16th (1986) Kenichi Matsubara, Masaaki Terada and Tadashi Yamamoto
Molecular Biological Studies on Novel Oncogenes
17th (1987) Tamaki Kajitani and Keiichi Suemasu
Contribution to the Improvement of Surgical Treatment for Cancer
18th (1988) Toju Hata and Shigetoshi WakakiStudies on Anti-cancer Agent Mitomycin
Prize of the Princess Takamatsu Cancer Research Fund for Special Occasion of the 20thAnniversary (1988)
Susumu Nishimura, Eiko Ohtsuka and Sung-Hou Kim
Determination of Three-dimensional Structure of c-Ha-ras Oncogene Product, P21
Protein19th (1989) Keishi Matsumoto
Molecular Mechanisms Involved in Sex Hormone-induced Growth of Cancer Cells
Sadaaki Kawai
Genetic and Molecular Biology of Avian Retroviruses
20th (1990) Yoshio Sakurai and Takashi Tsuruo
Molecular Mechanisms of Anti-cancer Drug Resistance in Cells and Implicationsof Therapy
Toshio Takahashi
Improved End-results among Cancer Patients Using Selective Cancer Treatments
21st (1991)

Akira Ichihara and Toshikazu Nakamura
Hepatocyte Growth Factor in Relation to Liver Regeneration and Carcinogenesis
Mitsuyuki Abe and Yoichiro Umegaki
Contribution to Development in the Field of Radiation Therapy, Including Direct
View Intraoperative Irradiation

22nd (1992) Yusuke Nakamura, Makoto Noda, Mitsuo Oshimura, Takao Sekiya and Jun Yokota
New Approaches to Studies on Tumor-suppressor Genes in Cancers
Tetsuichiro Muto and Kyosuke Ushio
Natural History of Colorectal Cancer and Its Clinical Significance23rd (1993) Yoshiaki Ito and Misao Ohki
The Gene and Its Product Responsible for Acute Myclocytic Leukemia with T(8:21)
Hikoo Shirakabe and Heizaburo IchikawaDevelopment of Double Contrast Radiography for Gastrointestinal Cancers
24th (1994) Masatoshi Takeichi, Setsuo Hirohashi and Shoichiro Tsukita
Discovery of Cadherin-catenin System for Cell Adhesion and Its Abnormality
in Cancer
Isaburo Fujimoto and Aya Hanai
Establishment of Population based Cancer Registry and Its Use for EpidemiologicalStudies on Cancer
25th (1995) Tadatsugu TaniguchiInterferon Regulatory Factors and Molecular Mechanism of Carcinogenesis
Kazuyuki Ishihara
Treatment of Melanoma among Japanese26th (1996) Hiroshi Maeda
Tumor Selective Drug Targeting with Macromolecular Anticancer AgentsTsuguo Naruke
The Improvement of Survival and Quality of Life in Lung Cancer Patients
27th (1997) Shigekazu Nagata and Shin Yonehara
Discovery of Fas Antigen and Elucidation of Molecular Mechanism of Apoptosis
Yuji Nimura
Establishment of Radical Operation for Hilar Cholangiocarcinoma
28th (1998) Yukihiko Kitamura
Role of C-kit in Growth, Differentiation and Malignancy of Mast Cells
and Interstitial Cells of Cajal
Satoshi Ebihara
Development of Surgical Treatment with Preservation of Function for Headand Neck Cancers
29th (1999) Kohei Miyazono
Mechanisms of Cell Growth Regulation and Transformation by TGF-Ken Yamaguchi
Development of Tumor Marker "ProGRP" for Small Cell Lung Carcinoma
30th (2000) Yoichi Konishi
Studies on Experimental Pancreatic Cancer
Masanori ShimoyamaContribution to the Establishment of High-quality Clinical Cancer Chemotherapy
31st (2001)

Yoichi TayaThe Biological Significance of Phosphorylation of the Tumor Suppressor RB
Protein and p53
Kazuo Tajima, Shigeo Hino and Shunro Sonoda
Prevention of Mother-to-Child Transmission of Adult T-cell Leukemia Virus(HTLV-1) by Avoiding Breast Feeding

32nd (2002) Okio Hiono
Molecular Mechanism of Hereditary Rat Renal Cancer
Tetsuhiko Shirasaka
A Novel Cancer Chemotherapy by Biochemical Modulation of 5-Fluorouracil
33rd (2003) Shizuo Akira
Rols of Toll-like Receptors in Cancer Immunotherapy
Akihiro Kaneko
Eye-preservation Therapy for Ophthalmic Malignant Tumors
34th (2004) Yoshiro Niitsu, Hideki Mori and Keiji Wakabayashi
The Studies of Colon Cancer Causative and Preventive Agents
Yasuo Hirao and Hirohiko Tsujii
Development of Heavy Iron Therapy Facility for Cancer Treatment and Its
Clinical Application
35th (2005) Tetsuya Kamataki and Yoshiaki Fujii
Role of Cytochrome P450 in Chemical Carcinogenesis and Its Gene Regulation
Noriyuki Moriyama
The Studies of Development of Helical Computed Tomography

36th (2006) Hiroyasu Esumi
Discovery of Novel Anti-cancer Agents Focusing on Cancer Cell Adaptation toOxygen and Nutrient Deprived Microenvironment
Masae Tatematsu and Fumihiro Hirayama
Experimental Studies on Gastric Carcinogenesis and Prevention using
Helicobacter Pylori Infected Mongolian Gerbils
37th (2007) Masabumi Shibuya
Isolation of Angiogenic Factor Receptor and Research on the Molecular Basis ofTumor Growth and Metastasis
Kazumasa Miki
Development of the Effective Gastric Cancer Screening System Using the Serum
Pepsinogen Level
38th (2008) Akira Nakagawara
Unveiling Molecular Mechanisms of Carcinogenesis, Aggressive Behavior andSpontaneous Regression as Well as Construction of Novel Systems for Predicting
Prognosis in Neuroblastoma
Naomi Uemura and Masahiro Asaka
A Study on Prevention of Secondary Gastric Cancer by Eradication of Helicobacter
Pylori39th (2009) Hiroyuki Mano
Discovery and Clinical Application of a Novel Lung Cancer Oncogene
Hisao Tajiri and Manabu Muto
Innovative Development of Endoscopic Technology for Diagnosis of Early Cancerand Clinical Research
40th (2010) Hiroyuki Tsuda and Tomoyuki ShiraiTransgenic Rat Models for Prevention, Early Diagnosis and Treatment ofPancreatic and Prostate Cancer
Haruo Sugiyama
Development of a Clinical Test for the Detection of Minimal Residual Disease of
Leukemia with High Sensitivity
41st (2011)

Tohru Tokunaga
Studies on Anti-tumor Activities of Single-stranded DNA Having CG-motifs
Ryuzo Ueda
Translational Research of Anti-CCR4 Antibody Therapy for Adult T-cell
Leukemia/Lymphoma

42nd (2012) Yoshinori Murakami
Analysis of a Novel Signaling Cascade Involved in Cell Adhesion andTumor Progression
Masaki Mori
Cancer Stem Cell Research of Digestive Organs
43rd (2013) Motoharu Seiki
Discovery and Ingenious Study of a Membrane Protease MT1-MMP in Cancer
Mitsuru Sasako
Clinical Studies in Surgical Oncology and Establishment of Standard Surgery for
Gastric Cancer in Europe

44th (2014) Hikoya Hayatsu
Discovery of Bisufite-mediated Deamination of Cytosine, the Reaction Essential for
Determining the Sites of 5-methylcytosines in the Sequencing of Epigenomes
Shoichiro Tsugane
Providing Evidence from a Large-scale Cohort Study and Proposing Cancer
Prevention Methods for Japanese
45th (2015) Seigo Kitano
Prospective Multi-center Trials for Laparoscopic Gastrointestinal Cancer Treatments
Kunitada Shimotohno
Prevention of Chronic Hepatitis and Hepatic Cancer Caused by HCV Infection
46th (2016) Seishi Ogawa
Studies on the Molecular Basis of Myelodysplastic Syndromes
Minoru Yoshida
Chemical Biology on Cancer Therapy Targeting Regulatory Molecules ofEpigenetics
47th (2017) Kazunori Kataoka
Creation of Polymeric Micellar-type Delivery Systems of Anti-cancer Drugs forClinical Application
Toshiyuki Sakai
Discovery of a First-in-class MEK Inhibitor Trametinib
48th (2018) Toshikazu UshijimaEpigenetic Field Cancerization-from Its Concept toward Clinical Translation
Tomoki Todo
Clinical Development of Oncolytic Virus Therapy Using GeneticallyEngineered Herpes Virus
49th (2019) Takahiro Ochiya
Early Detection of Cancer by Circulating microRNAs
Masahide Takahashi
Discovery of Girdin family proteins and their roles in cancer invasion andmetastasis
50th(2020)

Hara Eiji
Roles and mechanism of cellular senescence in the control of carcinogenesis
Kengo Takeuchi
Discovery of fusion kinase genes and development of diagnostic tools basedon immunohistopathology→Discovery of fusion kinase genes throughhistopathology and its application in cancer diagnosis

51st(2021)

Tatsuhiro Shibata
Comprehensive genomic analyses of intractable gastrointestinal cancers
towards precise diagnosis, treatment, and prevention
Masanori Hatakeyama

Elucidation of molecular mechanisms underlying gastriccarcinogenesis mediated by the Helicobacter pylori oncoprotein
CagA

52nd(2022) Hiroyoshi Nishikawa

Elucidation of immunosuppressive mechanisms in the tumor
microenvironment and clinical application
Yosuke Uchitomi
Development of Supportive, Palliative, and Psychosocial Care for Cancer Distress