ポスター

Poster

1 日目（9 月 24 日（火））／Day 1（Sep. 24 Tue.）
4F 天瑞・ホワイエ／4F TENZUI・Foyer
蛋⽩質：構造／Protein: Structure
1Pos001* HDX-MS を用いた Fc 断片と IgG1 全長の Fc 領域における構造解析
Structural analysis of IgG Fc region in Fc fragment and IgG1 full-body by HDX-MS
Yuki Yamaguchi1, Tesuo Torisu1, Susumu Uchiyama1,2 (1Grad. Sch., Eng., Univ. Osaka, 2ExCELLS)
1Pos002* 呼吸鎖における拡張型超複合体の Cryo-EM による構造の解明
Elucidation of the structure of extended super-complex in the respiratory chain by cryo-EM
Kasumi Hirakawa, Wataru Ishibashi, Tomoichirou Kusumoto, Junshi Sakamoto, Takuo Yasunaga (Grad.
Sch Comp. Sci. and Sys. Eng, Kyushu Inst. Tech.)
1Pos003* シゾロドプシンのプロトン輸送の構造基盤
Structural basis of proton transport in Schizorhodopsin
Akimitsu Higuchi1, Wataru Shihoya1, Keiichi Inoue2,3,4,5, Masae Konno2, Hideki Kandori2,3,
Osamu Nureki1 (1Department of Biological Sciences, Graduate School of science, University of Tokyo,
2Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, 3OptoBioTechnology
Research Center, Nagoya Institute of Technology, 4The Institute for Solid State Physics, The University ofTokyo, 5PRESTO, Japan Science and Technology Agency)
1Pos004* カチオン性抗菌ペプチド Hymenochirin-1Pa および変異体 D9K の細菌膜結合構造と膜選択性の解析
Membrane-bound structure and membrane selectivity of cationic antimicrobial peptide
Hymenochirin-1Pa and its analog D9K
Akifumi Ohyama1, Batsaikhan Mijiddorj2,3, Kazuyoshi Ueda2, Akira Naito2, Izuru Kawamura1,2 (1Grad.
Sch. Eng. Sci., Yokohama Natl. Univ, 2Grad. Sch. Eng., Yokohama Natl. Univ, 3Sch. Eng. Appl. Sci., Natl.
Univ. Mongolia)
1Pos005 (1SCP-5) The role of C-terminal carboxylation in α-conotoxin LsIA interactions with human α7nicotinic acetylcholine receptor in silico
Jierong Wen, Andrew Hung (Sch. Sci., RMIT Univ.)
1Pos006 分子動力学法を用いた Hras-GTP/GDP 複合体の各部の構造変化と各部の水素結合との同時緩和
モードの研究Molecular dynamics study of simultaneous relaxation modes between structures and thehydrogen bonds in the Hras-GTP/GDP complexes
Takeshi Miyakawa1, Ryota Morikawa1, Masako Takasu1,2, Kimikazu Sugimori2, Kazutomo Kawaguchi3,
Hidemi Nagao3 (1Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 2Inst. of Liberal Arts. & Sci.,
Kanazawa Univ., 3Coll. of Sci. and Eng., Kanazawa Univ.)
1Pos007 自動デザイン：分子シミュレーションデータを用いた自動ドラッグデザイン
AutoDesign - an automated drug design by using protein-ligand simulation data
Hironori Kokubo, Naoki Miyamoto, Yoshi Nara (Axcelead, Inc.)
1Pos008 Simulating large-amplitude transitions in proteins with a coarse-grained modelAi Shinobu1, Chigusa Kobayashi1, Yasuhiro Matsunaga2, Yuji Sugita1,3,4 (1RIKEN Center for
Computational Science, 2Saitama Univ., Grad. Sch. Sci. Eng., 3RIKEN Cluster for Pioneering Research,
4RIKEN Center for Biosystems Dynamics Research)
1Pos009 Dynamics and interdomain interactions in a Drosophila adapter protein (Drk) and theircorrelation to the unfolding of the N-SH3 domain
Hisham Dokainish1, Yusuke Suemoto2, Teppei Ikeya2, Takuma Kasai3, Takanori Kigawa3, Yutaka Ito2,
Yuji Sugita1 (1Riken, Theoretical Molecular Science Laboratory, 2Department of Chemistry, Tokyo
Metropolitan University, 3RIKEN, Center for Biosystems Dynamics Research)– S96 –

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微小管内タンパク質によるチューブリン格子構造の内側からの制御
Microtubule inner proteins regulate the tubulin lattice architecture from the inside
Muneyoshi Ichikawa1, Ahmad Khalifa2, Shintaroh Kubo3, Kaustuv Basu2, Daniel Dai2, Amin Maghrebi2,
Javier Vargas2, Khanh-Huy Bui2 (1Dept. of Systems Biol., NAIST, 2McGill Univ., 3Dept. Biophysics, Kyoto
Univ.)
小角散乱によるアミロイド線維中のヒト α-シヌクレインの構造解析
Structural analysis of human α-synuclein within amyloid fibrils by small-angle scattering
Satoru Fujiwara1, Tatsuhito Matsuo1, Yasunobu Sugimoto2 (1Inst. Quantum Life Science, QST, 2Nagoya
Univ.)
共溶媒の構造類似度を利用した共溶媒分子動力学法における密度マップの類似度の推定
Estimation of the probability map (Pmap) similarity of cosolvent MD (CMD) from structuralsimilarities of cosolvents
Keisuke Yanagisawa1, Yoshitaka Moriwaki1, Tohru Terada2,3, Kentaro Shimizu1,2 (1Grad. Sch. Agr. Life
Sci., Univ. Tokyo, 2III, Univ. Tokyo, 3Agr. Bioinfo. Res. Unit., Grad. Sch. Agr. Life Sci., Univ. Tokyo)
単量体タンパク質の長時間シミュレーションのフォールディングパスウェイの動的解析
Dynamical analysis on the folding pathways of long simulations of a single protein
Ayori Mitsutake1, Hiroshi Takano2 (1Meiji Univ., 2Keio Univ.)
Targeting the cryptic sites: NMR-based strategy to improve the draggability of proteins bycontrolling the conformational equilibrium
Koh Takeuchi1, Yumiko Mizukoshi2, Yuji Tokunaga1, Hitomi Matsuo2, Ichio Shimada3 (1AIST, molprof,
2JBiC, 3The Univ. Tokyo, Grad Sch Pharm Sci)
ヘリオロドプシンの構造と生物物理学的解析
Structure and biophysical characterization of the heliorhodopsin
Wataru Shihoya1, Keiichi Inoue2,3,4,5, Singh Manish2, Masae Konno2, Shoko Hososhima2,
Keitaro Yamashita1, Kento Ikeda6, Akimitsu Higuchi1, Sae Okazaki1, Izume Tamaki1,
Masanori Hashimoto2, Ritsu Mizutori2, Sahoko Tomida2, Yumeka Yamauchi2, Rei Abe-Yoshizumi2,
Kota Katayama2,3, P. Satoshi Tsunoda2, Mikihiro Shibata7,8, Yuji Furutani2,9,10, Alina Pushkarev11,
Oded Beja11, Takayuki Uchihashi12,13, Hideki Kandori2,3, Osamu Nureki1 (1Department of Biological
Sciences, Graduate School of Science, The University of Tokyo, 2Department of Life Science and Applied
Chemistry, Nagoya Institute of Technology, 3OptoBioTechnology Research Center, Nagoya Institute ofTechnology, 4The Institute for Solid State Physics, The University of Tokyo, 5RESTO, Japan Science andTechnology Agency, 6School of Mathematical and Physical Sciences, Graduate School of Natural Science& Technology, Kanazawa University, 7Nano Life Science Institute (WPI-NanoLSI), Kanazawa University,
8High-speed AFM for Biological Application Unit, Institute for Frontier Science Initiative, Kanazawa
University, 9Department of Life and Coordination-Complex Molecular Science, Institute for Molecular
Science, National Institutes of Natural Sciences, 10Department of Structural Molecular Science, The
Graduate University for Advanced Studies (SOKENDAI), 11Israel Institute of Technology, 12Department of
Physics, Nagoya University, 13Structural Biology Research Center, Graduate School of Science, Nagoya
University)
クロストリジウム属 2 成分毒素輸送チャネル Ib ポアのクライオ電子顕微鏡構造解析
Cryo-EM structure of clostridial binary toxin translocation channel Ib-pore
Tomohito Yamada1, Toru Yoshida1, Akira Kawamoto2, Kaoru Mitsuoka3, Kenji Iwasaki4, Hideaki Tsuge1(1Sch. Life Sci., Univ. Kyoto-sangyo, 2Protein inst., Univ. Osaka, 3Research Center for Ultra-High Voltage
Electron Microscopy, Univ. Osaka, 4Life Science Center for Survival Dynamics, Tsukuba Advanced
Research Alliance, Univ. of Tsukuba)
藍色細菌 Anabaena variabilis 由来 RNA 結合タンパク質の二次構造
Secondary structure of cyanobacterial RNA-binding protein, RbpD, from Anabaena variabilis
Hayato Morita1, Toshihiko Sugiki2, Chojiro Kojima2,3, Hidenori Hayashi4, Naoki Sato5 (1Fac. Sci., Josai.
Univ., 2Inst. Prot. Res., Osaka Univ., 3Fac. Eng. Yokohama. Nat. Univ., 4Grad. Sch. Sci. Eng., Ehime Univ.,
5Grad. Sch. Arts. Sci., Univ. Tokyo)– S97 –

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Hydrogen bond donors and acceptors are generally depolarized in α-helices as revealed by anegative fragmentation approach
Yu Takano1,2, Hiroko X. Kondo1,3, Ayumi Kusaka2, Shusuke Yamanaka4, Nakamura Haruki2 (1Grad. Sch.
Info. Sci., Hiroshima City U., 2IPR, Osaka U., 3Faculty Eng. Kitami Inst. Tech., 4Grad. Sch. Sci., Osaka U.)
Full atomistic model building of EhV-ATPase using homology modeling/molecular dynamics
simulation based on the low resolution cryoEM map
Yu Yamamori1, Jun Tsunoda2,3, Ray Burton-Smith3, Chihong Song3, Ryouta Iino2,4, Kazuyoshi Murata2,3,
Kentaro Tomii1 (1AIST, 2SOKENDAI, 3NIPS, 4IMS)
2 次元テンプレートマッチング法によるクロマチン構造多型解析への挑戦
Challenging for multi-conformational analysis of chromatin using the two-dimensional templatematching method
Atushi Tokuhisa1,2,3, Ryo Kanada1, Shuntaro Chiba2, Kei Terayama3,4,5, Shigeyuki Matsumoto2,
Yuta Isaka1,6, Biao Ma1,6, Narutoshi Kamiya7, Yasushi Okuno1,3,5,6 (1RCH, RIKEN, 2MIH,RIKEN, 3RCCS,RIKEN, 4AIP,RIKEN, 5Medicine,Kyoto U, 6CCD,FBRI, 7Simulation,U.Hyogo)(1SFP-4) 創薬標的タンパク質の中性子結晶構造解析(1SFP-4) Neutron crystallographic analysis of drug-target proteinsTakeshi Yokoyama (Fac. of Pharm. Sci., Univ. of Toyama)
Crystal structure of human Dishevelled1 PDZ with its inhibitor
Shotaro Yasukochi1, Nobutaka Numoto2, Kiminori Hori1, Natsuko Tenno1, Takeshi Tenno1,
Nobutoshi Ito2, Hidekazu Hiroaki1 (1Grad. Sch. Pharm Sci., Univ. Nagoya, 2Med Res Inst., TMDU)
蛋⽩質：構造機能相関／Protein: Structure & Function

1Pos023* 拡張アンサンブル法によるビタミン D 受容体のアゴニスト/アンタゴニスト活性調節機構の研究
Regulation mechanism of agonistic / antagonistic activities of vitamin D receptor studied bygeneralized ensemble method
Takafumi Kudo1, Toru Ekimoto1, Tsutomu Yamane1, Mitsunori Ikeguchi1,2 (1Grad. Sch. Med Life Sci.,
Yokohama City Univ., 2Med. Sci. Innov. Hub., Riken)
1Pos024* MARTINI 力場を用いた粗視化シミュレーションによる分子シャペロニン GroEL の ATP に誘起される構造変化の解析
Analysis of the ATP-induced conformational change of the molecular chaperonin GroEL bycoarse-grained simulations using the MARTINI
Yuya Yamaura, Tadaomi Furuta, Minoru Sakurai (Center for Biol. Res. & Inform., Tokyo Tech)
1Pos025* A Theoretically Study of ATP Effect on Solubility of Intrinsically Disordered Protein under
Crowded Environment
Hayato Aida1, Ryuhei Harada2, Yasuteru Shigeta2 (1Coll. Bio. Sci., Univ. Tsukuba, 2CCS, Univ. Tsukuba)
1Pos026* 脂質膜表面におけるシトクロム P450 還元酵素の誘電アロステリー
Dielectric allostery in cytochrome P450 reductase on the surface of lipid membrane
Mikuru Iijima, Jun Ohnuki, Mitsunori Takano (Dept. of Pure & Appl. Phys., Waseda Univ.)
1Pos027* TypeIII 中間径フィラメントの細胞表面上への出現機構の解明
Elucidation of recruitment mechanism of type III intermediate filament proteins to cell surface
Beomju Hwang1, Inu Song1, Hirohiko Ise2 (1Grad. Sch. Eng., Kyushu univ., 2IMCE, Kyushu Univ.)
1Pos028* 量子化学計算による EcoRV のシシルリン酸基ツイスト後のリン酸エステル加水分解反応の研究
DNA Hydrolysis by EcoRV Subsequent to Scissile-Phosphate Twist, Studied by QM/MM
Metadynamics Simulation
Itaru Onishi1, Norio Yoshida2, Fumio Hirata3,4, Masayuki Irisa1 (1Kyushu Inst. of Tech., 2Kyushu Univ.,
3IMS, 4Toyota Riken)
1Pos029 Crystal structure of branched-chain polyamine synthase
Eiichi Mizohata1,2, Masataka Toyoda1, Ryota Hidese3, Shinsuke Fujiwara3 (1Grad. Sch. Eng., Osaka Univ.,
2JST-PRESTO, 3Grad. Sch. Sci. Tech., Kwansei Gakuin Univ.)– S98 –

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Analysis of the complex molecular system composed of GGA, MPR and Ub by using titration
SAXS measurement
Yugo Hayashi1, Natsumi Endo1, Youichi Yamazaki1, Sachiko F. Toma1, Hironari Kamikubo1,2 (1Div. Mat.
Sci., NAIST, 2IMSS KEK)
Structural analysis of firefly luciferase with MM and QM/MM molecular simulations to clarify theorigin of emission color-change factors
Kota Nosaka, Naohisa Wada (Grad. Sch. Life Sci., Univ.Toyo)
シアノバクテリア概日時計における KaiC 六量体の構造多様性
Structural Diversity of KaiC Hexamer in Cyanobacterial Circadian ClockYoshihiko Furuike1,2, Atsushi Mukaiyama1,2, Eiki Yamashita3, Takao Kondo4, Shuji Akiyama1,2(1Research Center of Integrative Molecular Systems (CIMoS), Institute for Molecular Science (IMS),
2Department of Functional Molecular Science, SOKENDAI (The Graduate University for Advanced
Studies), 3Institute for Protein Research, Osaka University, 4Graduate School of Science, Nagoya
University)
NMR analysis of metal ion-induced conformational changes of α-helical peptides
Ikuko Iizumi1, Yohei Miyanoiri2, Toshiki Tanaka3, Masayuki Oda1 (1Grad. Sch. Life Environ. Sci., Kyoto
Pref. Univ., 2Inst. Protein Res., Osaka Univ., 3Nagoya Inst. Technol.)
シクロスポリン A の CHARMM 力場の開発と膜―水系の分子動力学シミュレーションへの応用
Development of the CHARMM force field for Cyclosporine A and application to molecular
dynamics simulations using a membrane-water system
Tsutomu Yamane1, Ryo Takahashi1, Toru Ekimoto1, Mitsunori Ikeguchi1,2 (1Grad. Sch. Med. Life Sci,
Yokohama City Univ., 2RIKEN Med. Sci. Innov. Hub)ヒト成人ヘモグロビンの酸素親和性制御に関連した GHz, THz 領域振動の研究
Study on Giga- and Terahertz-frequency Motions Involved with Oxygen Affinity of Human Adult
Hemoglobin
Shigenori Nagatomo1, Kohji Yamamoto2, Masako Nagai3, Teizo Kitagawa4 (1Dept. Chem., Univ. Tsukuba,
2Res. Center Develop. Far-IR Region, Univ. Fukui, 3Res. Center Micro-Nano Tech., Hosei Univ., 4Grad.
Sch.Life Sci., Univ. Hyogo)
Structural basis for the intramolecular signal transduction of oxygen sensor protein FixL from
Bradyrhizobium japonicum
Misaki Kamaya1, Hiroyasu Koteishi1, Takehiko Tosha1,2, Seiki Baba3, Hiroshi Sugimoto1,2,
Yoshitsugu Shiro1, Hitomi Sawai1,2 (1Grad. Sch. Sci., Univ. Hyogo, 2RIKEN SPring-8, 3SPring-8 / JASRI)
心筋ナトリウムチャネル Nav1.5 と薬剤間の結合自由エネルギー計算
Calculation of the binding free energies between the Nav1.5 sodium channel and drug
molecules
Tatsuki Negami1, Tohru Terada2 (1Grad. Sch. Agr. Life Sci., Univ. Tokyo, 2III, Univ. Tokyo)
DNA 修復にかかわる Hef の天然変性領域の構造と機能
The structure and function of intrinsically disordered region of Hef that is associated with a DNA
repairTakashi Oda1, Ayako Sekino1, Ayaka Murakami1, Rika Oi1, Maki Yoneyama1, Noriyuki Kodera2,
Toshio Ando2, Tsuyoshi Konuma3, Kenji Sugase3, Tomotaka Oroguchi4, Sonoko Ishino5,
Yoshizumi Ishino5, Mamoru Sato1 (1Grad. Sch. of Med. Life Sci., Yokohama City Unv., 2WPI NanoLSI,
Kanazawa Univ., 3Grad.Sch. of Eng., Kyoto Univ., 4Faclt. Sci. Tech., Keio Univ., 5Grad. Sch. of
Bioresource & Bioenviron. Sci., Kyushu Univ.)
T2-like ファージ宿主認識蛋⽩質と宿主 OmpC の相互作用解析
Structural and functional analysis of phage receptor binding protein and OmpC
Shuji Kanamaru (Dep. of Life Sci. & Tech., Tokyo Inst. of Tech.)
ヤナギマツタケ（Agrocybe cylindracea）の Pri3 遺伝子のクローニングと特性解析
Cloning and characterization of the Pri3 gene of the edible mushroom, Agrocybe cylindracea
Chika Abematsu1, Yamato Kuratani1, Masashi Shin1, Makoto Iwata2, Toshihiko Matsumoto1, Shoji Ando1(1Fac. Biotech. Life Sci., Sojo Univ., 2IMB)– S99 –

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ヒトヘアケラチン K85 の遺伝子導入細胞における機能特性と外胚葉形成不全症の原因となる変異の影響
Functional characteristics of human hair keratin K85 in transfected cells and the effects ofmutations causative of ectodermal dysplasia
Masaki Yamamoto1, Yasuko Sakamoto1, Yuko Honda2, Kenzo Koike3, Hideaki Nakamura4,
Toshihiko Matsumoto1, Shoji Ando1 (1Fac. Biotech. Life Sci., Sojo Univ., 2Fac. Med., Saga Univ., 3Kao
corp., 4Fac. Phar., Sojo Univ.)
巨大ヘモグロビンのアロステリック中間体の時分割構造解析
Time-resolved structure analysis of allosteric intermediate of the giant hemoglobin
Nobutaka Numoto1, Yoshihiro Fukumori2, Kunio Miki3, Nobutoshi Ito1 (1Med. Res. Inst., Tokyo Med.
Dent. Univ. (TMDU), 2College Sci. Eng., Kanazawa Univ., 3Grad. Sch. Sci., Kyoto Univ.)
蛋⽩質：物性・構造／Protein: Property & Structure

1Pos043* 分子動力学法による RvSAHS1 の構造安定性
Structural stability of RvSAHS1 by MD simulations
Kazuhisa Miyazawa1,2,3, Satoru Itoh1,2,3, Hisashi Okumura1,2,3 (1SOKENDAI, 2IMS, 3ExCELLS)
1Pos044* Rheo-NMR 法によるスーパーオキシドジスムターゼ 1 の動的なアミロイド形成機構の解析
Dynamic Analysis of Amyloid Formation of Superoxide Dismutase 1 Using Rheo-NMR
Spectroscopy
Naoto Iwakawa1, Daichi Morimoto1, Erik Walinda2, Masahiro Shirakawa1, Kenji Sugase1 (1Grad. Sch.
Eng., Kyoto Univ., 2Grad. Sch. Med., Kyoto Univ.)
1Pos045* 統計力学モデルの拡張によるタンパク質のフォールディング反応機構の予測
Prediction of protein folding mechanisms by an extended statistical mechanical model
Koji Ooka1, Munehito Arai1,2 (1Dept. Phys., Univ. Tokyo, 2Dept. Life Sci., Univ. Tokyo)
1Pos046 低波数基準振動で特徴づけられた多量体蛋⽩質の動的性質
Dynamic properties of oligomeric proteins characterized by low-frequency normal modes
Hiroshi Wako2, Shigeru Endo1 (1Dept. of Phys., Sch. of Sci., Kitasato Univ., 2Sch. of Social Sci., Waseda
Univ.)
1Pos047 粗視化 Go モデルを用いた GA・GB ドメイン関連タンパク質のフォールディング機構の相違・共通性の予測
Prediction of differences and commonality in folding mechanisms of GA / GB domain related
proteins using coarse-grained Go model
Shoya Hamaue (Dept. of Bioinfo., Col. of Life sci., Ritsumeikan Univ.)
1Pos048 Mechanism of the spontaneous elongation of the fibroin nanofiber involved in spider silk
Takuya Sawai1, Kiichi Hayashi1, Yugo Hayashi1, Takehiro Sato2, Yoichi Yamazaki1,
Sachiko Toma-Fukai1, Hironari Kamikubo1,3 (1Div. Mat. Sci., NAIST, 2Spiber Inc., 3IMSS KEK)
1Pos049 天然様階層構造を有する人工クモ糸材料の再構成
Reconstitution of artificial materials of spider silk accompanied by native-like hierarchicalstructure
Satoru Onishi1, Yuki Nakatani1, Yugo Hayashi1, Takehiro Sato2, Yoichi Yamazaki1,
Sachiko Toma-Fukai1, Hironari Kamikubo1,3 (1Div. Mat. Sci., NAIST, 2Spiber Inc., 3IMSS KEK)
蛋⽩質：機能／Protein: Function
1Pos050* ヒト SOD1 と Zn 欠損 SOD との比較による亜鉛と静電ポテンシャルループの役割に関する研究
Investigation on role of zinc atom and electrostatic loop by comparing human SOD1 with Zndeficient SOD
Natsumi Koyama1, Masami Lintuluoto1, Juha Lintuluoto2 (1Grad. Sch. Life and Environ. sci., Kyoto pref.
univ., 2Grad. sch. eng., Kyoto univ.)– S100 –1Pos051

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点変異導入による CD44 のヒアルロン酸結合のアロステリック制御
Allosteric regulation of hyaluronan binding on CD44 by point mutation
Masami Lintuluoto1, Youta Horioka1, Katsuhisa Matsumoto1, Saki Hongo1, Juha Lintuluoto2 (1Grad. Sch.
Life and Environ. Sci., Kyoto pref. univ., 2Grad. sch. eng., Kyoto Univ.)
アミロイド β42 を用いた天然変性タンパク質の分子シールド効果の評価
The evaluation of molecular shield effect of intrinsically disordered proteins using amyloid beta
1-42
Koki Ikeda, Yoshiki Shigemitsu, Natsuko Tenno, Takeshi Tenno, Hidekazu Hiroaki (Grad. Sch. Pharm
Sci., Univ. Nagoya)
X 線小角散乱を用いた大腸菌フェリチンの鉄コアの形成に関する研究
The iron core formation of E. coli ferritin studied by small angle X-ray scattering
Takumi Kuwata, Daisuke Sato, Kazuo Fujiwara, Masamichi Ikeguchi (Department of Bioinformatics,
Soka University)
柔らかいドライブシャフトを持つ F1-ATPase のトルク伝達/発生
Torque transmission/generation of F1-ATPase with a soft driveshaft
Shou Furuike1, Naoki Soga2, Yasushi Maki1, Hideji Yoshida1 (1Phys., Osaka Med. Coll., 2Grad. Sch. Eng.,
Univ. Tokyo)
蛋⽩質：計測・解析／Protein: Measurement & Analysis

1Pos055* (1SDP-3) Biophysical analysis of alpha-synuclein oligomers by microchip electrophoresis
William E. Arter1,2, Catherine K. Xu1, Georg Krainer1, Christopher M. Dobson1, Tuomas P. J. Knowles1,2(1Centre for Misfolding Disease, Department of Chemistry, University of Cambridge, 2Cavendish
Laboratory, Department of Physics, University of Cambridge)
1Pos056* タンパク質内部の構造変化をプローブするためのアスパラギン酸マッピングと赤外分光解析
Mapping of aspartic acids to probe protein structural changes by FTIR spectroscopy
Masanori Hashimoto, Kota Katayama, Manish Singh, Yuji Furutani, Hideki Kandori (Grad. Sch. Eng.,
Nagoya Inst. Tech.)
1Pos057* バイオ医薬品中の蛋⽩質凝集体の定量手法の確立
Establishment of quantification methods for protein aggregates in biopharmaceuticals
Saki Yoneda1, Bertram Niederleitner2, Michael Wiggenhorn2, Hiroki Koga1, Shinichiro Totoki3,
Elena Krayukhina1, Wolfgang Friess4, Susumu Uchiyama1,5 (1Dept. biotech. grad. sch. eng., Osaka. univ,
2Coriolis Pharma, 3Shimadzu Corporation, 4LMU, Dept.Phaemacy, 5ExCELLS)
1Pos058 (1SDP-6) 新規に開発した高濃度タンパク質のためのネガティブ染色電子顕微鏡法(1SDP-6) A newly developed negative stain EM method for protein complexes at high protein
concentration
Hiroshi Imai1, Takayuki Kato2, Gerle Christoph3, Etsuko Muto4, Kaoru Mitsuoka5, Genji Kurisu3,
Keiichi Namba2, Takahide Kon1 (1Grad. Sch. Sci., Osaka Univ., 2Grad. Sch. Frontier Biosci., Osaka Univ.,
3IPR, Osaka Univ., 4CBS, RIKEN, 5Res. Ctr. UVHEM, Osaka Univ.)
1Pos059 模倣細胞内分子混雑環境及び糖ガラス中の特定のタンパク質及び脂質膜の構造の中性子散乱による研究
Study of protein or membrane structure in mimicking intra-cell molecular-crowding environment
and in sugar-glass using neutron scattering
Mitsuhiro Hirai1, Satoshi Ajito1, Shigeki Arai2, Shinichi Takata3, Hiroki Iwase4 (1Graduate School of
Science and Technology, Gunma University, 2National Institute for Quantum and Radiological Science andTechnology, 3J-PARC Center, Japan Atomic Energy Agency, 4Comprehensive Research Organization for
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1Pos063

TRPV1 分子内部の回転動態の決定
Agonist- and antagonist-induced rotational motion of TRPV1 channel
Shoko Fujimura1, Kazuhiro Mio1, Masahiro Kuramochi2, Sekiguchi Hiroshi3, Muneyo Mio1, Tai Kubo1,
Yuji Sasaki1,2,3 (1Operand OIL, National Institute of Advanced Industrial Science and Technology, Tokyo,
Japan, 2Graduate School of Frontier Sciences, The Univ. Tokyo, Chiba, Japan, 3Japan Synchrotron
Radiation Research Institute, Hyogo, Japan)
レプリカ部分置換法の開発とタンパク質への応用
Development of replica sub-permutation method and its application to mini-protein
Masataka Yamauchi1,2,3, Hisashi Okumura1,2,3 (1SOKENDAI, 2ExCELLS, 3IMS)凝縮系の不均一動力学(dynamical disorder)の分子論開拓: タンパク質の構造遷移・揺らぎ階層性
Theoretical investigations on microscopic heterogeneity and hierarchy in transitions andfluctuations of protein conformations
Yoshihiro Matsumura1, Shinji Saito1,2 (1IMS, 2SOKENDAI)
Lytic polysaccharide monooxygenase の生化学および 1 分子解析
Biochemical and single-molecule analyses of lytic polysaccharide monooxygenase
Siti Mastura Zakaria1,2, Akihiko Nakamura1,3, Yasuko Okuni1, Mayuko Yamamoto1, Akasit Visootsat1,3,
Jun Ando1,3, Ryota Iino1,3 (1IMS, NINS, 2Univ. of Malaya, 3SOKENDAI)
蛋⽩質工学／Protein: Engineering

1Pos064
1Pos065

1Pos066

1Pos067

1Pos068

1Pos069

Relationship between loop geometry and register shift in parallel beta-sheet proteins
Ryuichiro Ueda, George Chikenji (Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.)
2 アミノ酸同時変異戦略を用いた SBDD による超高親和性抗体の創製
Structure-based discovery of the antibodies with sub-picomolar affinity using the double aminoacid mutation strategy
Shuntaro Chiba1, Masateru Ohta1, Aki Tanabe2, Makoto Nakakido2, Kouhei Tsumoto2,3, Yasushi Okuno1,4(1MIH, RIKEN, 2Sch. Eng., Univ. Tokyo, 3Inst. Med. Sci., Univ. Tokyo, 4Grad. Sch. Med., Kyoto Univ.)
転写コアクチベータ CBP の KIX ドメインと転写因子間の相互作用を阻害するペプチドの合理的設計
Rational design of peptides that inhibit interactions between the KIX domain of CBP andtranscription factors
Nao Sato1, Shunji Suetaka1, Yuuki Hayashi1, Munehito Arai1,2 (1Dept. Life Sci., Univ. Tokyo, 2Dept. Phys.,Univ. Tokyo)
分子動力学シミュレーションを用いた CDR-Grafting による合成単ドメイン抗体の構造的変化の解析
Structural effects of CDR grafting of synthetic single domain antibodies investigated bymolecular dynamics simulations
Seisho Kinoshita1, Chinatsu Mori2, Makoto Nakakido1,2, Daisuke Kuroda1,2,3, Jose Caaveiro4,
Kouhei Tsumoto1,2,3,5 (1Dept. of Bioeng., Sch. of Eng., Univ. of Tokyo, 2Dept. of Chem. Biotech., Sch. ofEng., Univ. of Tokyo, 3Med. Dev. Dev. Reg. Res. Center, Sch. of Eng., Univ. of Tokyo, 4Grad. Sch. of
Pharm. Sci., Kyushu Univ., 5Inst. of Med. Sci., Univ. of Tokyo)
アレルギー性喘息に関わるインターロイキン 33 の阻害剤開発に向けて
Toward the development of an inhibitor of interleukin-33 responsible for allergic asthma
Mio Sano1, Yoshiki Oka1, Yuuki Hayashi1, Munehito Arai1,2 (1Dept. Life Sci., Univ. Tokyo, 2Dept. Phys.,Univ. Tokyo)
Domain-specific monitoring of higher-order structure of therapeutic IgG on the basis ofmolecular recognition of artificial proteins
Hideki Watanabe1, Naoko Hayashida2, Shinya Honda1,2 (1BMRI, AIST, 2Grad. Sci. of Fro., Univ. ofTokyo)– S102 –1Pos070

主鎖環状化が顆粒球コロニー刺激因子に与える会合体抑制効果
An effect of resistance to self-association of backbone circularization on granulocyte-colony
stimulating factor
Risa Shibuya1, Takamitsu Miyafusa2, Shinya Honda1,2 (1Grad. Sch. of Fro., Univ. of Tokyo, 2BMRI, AIST)
ヘム蛋⽩質／Heme proteins

1Pos071
1Pos072

1Pos073

Function of N-terminal acetylation of fish hemoglobin α-subunit
Satoru Unzai, Antonio Tsunesige (Hosei University, Department of Frontier Bioscience)
Functional roles of conserved residues near the active site of nitric oxide reductase based on
the structural analysis
Takehiko Tosha1, Raika Yamagiwa2, Takuya Kurahashi2, Hiroshi Sugimoto1, Yoshitsugu Shiro2 (1RIKEN
SPring-8, 2Univ. of Hyogo)
2―状態アロステリ―モデルの再検討ー機能的階層の有無
INSIGHT INTO THE TWO-STATE ALLOSTERIC MODEL - ON THE EXISTENCE OF
HIERARCHIES
Antonio Tsuneshige, Satoru Unzai (Hosei Univ. Frontier Bioscience)
膜蛋⽩質／Membrane proteins

1Pos074* (1SCA-2) 脂質分子の混み合い効果による膜貫通タンパク質結晶化の検討(1SCA-2) Crystallization of transmembrane protein driven by molecular crowding effect of lipids:
Theoretical estimation by using a simple model
Keiju Suda1, Ayumi Suematsu2, Ryo Akiyama1 (1Kyushu University, Sci., 2Kyushu Sangyo University,
Science and Engineering)
1Pos075* アミロイド前駆体タンパク質と β 切断酵素の膜貫通部位の生体膜中での相互作用
Interaction between amyloid precursor protein and beta-secretase in the bio-membrane
Kaori Yanagino, Naoyuki Miyashita (BOST KINDAI)
1Pos076* 多次元固体 NMR による細胞膜中のヘリオロドプシンの構造解析
Multidimensional solid-state NMR study of heliorhodopsin in a lipid environment
Shibuki Suzuki1, Toshio Nagashima2, Rina Kaneko1, Takashi Okitsu3, Akimori Wada3,
Naohiro Kobayashi2, Toshio Yamazaki2, Rei Abe-Yoshizumi4, Keiichi Inoue5, Hideki Kandori4,
Izuru Kawamura1 (1Grad. Sch. Eng. Sci., Yokohama National Univ., 2RIKEN RSC, 3Kobe Pharmaceutical
Univ., 4Nagoya Inst. Tech., 5Univ. Tokyo)
1Pos077 (1SHP-6) 理論計算による熱安定化ムスカリン M2 受容体の選択的アンタゴニスト AF-DX 384 結合型構造(1SHP-6) Structural insights into the subtype-selective antagonist binding to the M2 muscarinic
receptor
Ryoji Suno1, Sangbae Lee2, Shoji Maeda3, Satoshi Yasuda4, Keitaro Yamashita9, Kunio Hirata5,6,
Takeshi Murata7, Masahiro Kinoshita8, Masaki Yamamoto5, Brian Kobilka3, Nagarajan Vaidehi2,
So Iwata8, Takuya Kobayashi1 (1Kansai Medi. Univ., 2City Hope Med Ctr., 3Stanford Univ., 4Chiba Univ.,
5RIKEN,SPring-8, 6JST,PRESTO, 7IAE, Kyoto Univ., 8Med,Kyoto Univ., 9Univ.Tokyo,Sci)
1Pos078 (1SCA-4) cDNA ディスプレイとセルソーターの利用による新規リポソームポア形成ペプチドの創製(1SCA-4) Novel pore-forming peptides assembling in liposome membranes selected by
combining cDNA display method with cell sorter system
Naoto Nemoto1, Toshiki Miyajima1, Takeru Yoshinobu1, Yusuke Sekiya2, Ryuji Kawano2 (1Grad. Sci.
Eng., Saitama Univ., 2Dept. Biotech. Life Sci., Tokyo Univ. Agr. Tech)– S103 –1Pos079

1Pos080

特異的な残基置換が、水和水のダイナミクスにおよぼす影響を、解析するソフトを開発
Development of software to analyze the effects of specific residue substitution on hydrationwater dynamics
Ryoi Ashida, Nobuya Hasegawa, Takuya Azami, Kota Kasahara, Takuya Takahashi (Graduate School ofLife Science, Ritsumeikan University)
A comparative study of membrane-bound structure of antimicrobial peptides L- and Dphenylseptin
Izuru Kawamura1, Batsaikhan Mijiddorj1, Hisako Sato2, Yuta Matsuo1, Akira Naito1, Kazuyoshi Ueda1(1Grad.Sch. Eng., Yokohama Natl. Univ., 2Grad. Sch. Sci. Eng.)
核酸結合蛋⽩質／Nucleic acid binding proteins

1Pos081* Observation of Tumor Suppressor p53 Search Dynamics using Sub-millisecond Resolved
Single-molecule Fluorescence Microscopy
Dwiky Rendra Graha Subekti1,2, Agato Murata1, Yuji Itoh1, Satoshi Takahashi1, Kiyoto Kamagata1(1IMRAM, Tohoku Univ., 2Grad. Sch. Sci., Tohoku Univ.)
1Pos082 (1SBA-6) 大腸菌非六量体型 DNA ヘリカーゼ UvrD C 末端欠損変異体の 1 分子イメージング(1SBA-6) Single-molecule imaging of a non-hexameric Escherichia coli helicase UvrD mutant
lacking C-terminal residues
Hiroaki Yokota (Biophotonics Lab., Grad. Sch. Creation New Photon. Indust.)
1Pos083 スピンラベル ESR によるヘテロクロマチンタンパク質 HP1 の動的構造の研究：アイソフォーム
特異性とリン酸化
Structural dynamics of heterochromatin protein HP1 studied by spin labeling ESR spectroscopy:
Isoform specificity and phosphorylation
Toshiaki Arata1,5, Shigeaki Nakazawa4, Yuichi Mishima5, Kazunobu Sato4, Takeji Takui4,
Toru Kawakami5, Hironobu Hojo5, Toshimichi Fujiwara5, Makoto Miyata1, Isao Suetake2,3,5 (1Dept. Biol.,Grad. Sch. Sci., Osaka City Univ., 2Koshien Univ., 3Twin Research Center, Osaka Univ., 4Dept. Chem.,
Grad. Sch. Sci., Osaka City Univ., 5IPR, Osaka Univ.)
1Pos084 Protein localization in DNA cruciform junction studied by molecular simulation
Mami Saito, Shoji Takada (Dept Biophysics, Div Biology, Grad School Science, Kyoto University)
1Pos085 HIV Vif–ヒト E3 ユビキチンリガーゼ複合体によるヒト抗ウイルス因子 APOBEC3G の脱アミノ化
阻害の分子メカニズム
Inhibition mechanism of HIV Vif-human E3 ubiquitin ligase complex against enzymatic activity of
APOBEC3G
Keisuke Kamba1, Li Wan1,2, Satoru Unzai3, Ryo Morishita4, Takashi Nagata1,2, Masato Katahira1,2 (1Inst.
of Adv. Energy, Kyoto Univ., 2Grad. Sch. Energy Sci., Kyoto Univ., 3Front. Biosci., Hosei Univ., 4CellFree
Sciences Co.,Ltd.)
核酸／Nucleic acid
1Pos086* 薬剤によるリボスイッチ“SPINACH”の構造とイオンへの影響
Influence on the structure and dynamics of Riboswitch “SPINACH” and potassium ions by
DFHBI
Lisa Matsukura1, Nobutaka Onishi1, Masaya Furue1, Naoyuki Miyashita1, Takuma Shiraki1,
Yasushige Yonezawa2 (1BOST, KINDAI, 2IAT, KINDAI)
1Pos087* シスプラチンは二本鎖 DNA を桁違いに硬くする：一分子揺らぎの定量的解析
Cisplatin causes DNA much stiffer: Quantitative evaluation viscoelasticity through the analysis
of single molecule fluctuation
Toshifumi Kishimoto1, Yuko Yoshikawa1, Seiji Komeda2, Kenichi Yoshikawa1 (1Grad.Sch.Life
Med.Sci.,Univ.Doshisha, 2Fac.Pharm.,Univ.Suzuka.Med.Sci)– S104 –(1SEA-6) エピジェネティック修飾をもつクロマチンのモデルにおける不連続相転移(1SEA-6) Discontinuous Phase Transition in a Chromatin Model with Epigenetic Modification
Kyosuke Adachi, Kyogo Kawaguchi (RIKEN BDR)
1Pos089 トリヌクレオソームから構築するポリヌクレオソーム構造の特徴
Characterization of Poly-nucleosome Structure Constructed from Tri-nucleosome
Hiroo Kenzaki1, Shoji Takada2 (1Info. Sys. Div., ISC, RIKEN, 2Dept. Biophys., Grad. Sch. Sci., Kyoto
Univ.)
1Pos090 局所変形下における絡まりあった DNA 溶液の緩和過程
Relaxation process of entangled DNA solution after local deformation
Akinori Miyamoto, Yoshihiro Murayama (Department of Applied Physics,Tokyo University of Agri. andTech.)
1Pos091 In-cell NMR 法を用いたヒト生細胞内核酸の構造およびダイナミクスの評価
Evaluation of the structure and dynamics of nucleic acids inside the living human cells by in-cell
NMR spectroscopy
Yudai Yamaoki1, Takashi Nagata1,2, Ayaka Kiyoishi2, Masayuki Miyake2, Fumi Kano3,
Masayuki Murata3,4, Masato Katahira1,2 (1Inst. Adv. Energy, Kyoto Univ., 2Grad. Sch. Energy Sci., Kyoto
Univ., 3Inst. Innovative Res., Tokyo Inst. Technol., 4Grad. Sch. Arts and Sci., Univ. Tokyo)
1Pos092 ハンマーヘッドリボザイムの酵素反応に関する理論的研究
Theoretical study on an enzymatic reaction of the hammerhead ribozyme
Ayaka Matsuyama, Masahiko Taguchi, Shigehiko Hayashi (Kyoto University)
1Pos093* 2 価ポリアミンが引き起こす遺伝子発現の促進と抑制：アミノ基間の炭素鎖長の重要性
Promotion and inhibition of gene expression caused by divalent polyamines: Marked effect ofthe distance between amino groups
Hiroko Tanaka1, Chwen-Yang Shew2, Yuko Yoshikawa1, Takahiro Kenmotsu1, Kenichi Yoshikawa1(1Grad. Sch. Life. Med. Sci., Univ. Doshisha, 2Col. Chem., City Univ. New York)
1Pos094* Theoretical Studies on the Conformational Stability of RA-VII complex with 60S Ribosome
Arwansyah MS1, Yoh Noguchi2, Takeshi Miyakawa2, Kazutomo Kawaguchi1, Yukio Hitotsuyanagi3,
Satoshi Yokojima3, Ryota Morikawa2, Masako Takasu2, Hidemi Nagao1 (1Division of Mathematical andPhysical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, 2School ofLife Science, Tokyo University of Pharmacy and Life Sciences, 3School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences)
1Pos095 (1SEA-3) オリゴペプチドのアミノ酸配列は DNA compaction と転写活性に著しい違いを引き起
こす(1SEA-3) Marked Difference in DNA Compaction and Transcription is Caused by Amino Acid
Sequence of Oligopeptide
Tatsuo Akitaya1, Hiroyuki Hiramatsu2, Hideaki Yamaguchi3, Koji Kubo4, Shizuaki Murata4,
Toshio Kanbe5, Norio Hazemoto6, Kenichi Yoshikawa7, Anatoly Zinchenko4 (1Asahikawa Med. Univ.,
2Fac. Pharm., Meijo Univ., 3Fac. Agr. Sci., Meijo Univ., 4Grad. Sch. Env. Std., Nagoya Univ., 5Grad. Sch.
Med., Nagoya Univ., 6Grad. Sch. Pharm. Sci., Nggoya City Univ., 7Fac. Bio. Med. Sci., Doshisah Univ.)
1Pos088

電子状態／Electronic state
1Pos096
1Pos097
1Pos098

Long-range Electron-Electron Interaction and Charge Transfer in Protein ComplexesDavid Gnandt, Thorsten Koslowski (Institute of Physical Chemistry, University of Freiburg)—
拘束条件を用いた DFTB-MD シミュレーションの高速化とエネルギー保存の評価
Accelerate simulations and assessment of the energy conservation for the DFTB-MD
simulations using the constraint method
Hiroaki Nishizawa, Yasuteru Shigeta (CCS, Univ. of Tsukuba)– S105 –1Pos099

光合成系 II の酸素発生中心の S1 状態での 12 の構造モデルの DLPNO-CCSD(T)法による計算
DLPNO-CCSD(T) calculations of twelve structural models for the S1 state of oxygen evolving
complex of photosystem II
Koichi Miyagawa1, Takashi Kawakami2,5, Hiroshi Isobe3, Mitsuo Shoji4, Shusuke Yamanaka2,
Kazuhiko Nakatani1, Mitsutaka Okumura2, Takahito Nakajima5, Kizashi Yamaguchi1,5,6 (1ISIR, Osaka
Univ., 2Grad. Sch. of Sci., Osaka Univ., 3Grad. Sch. of Nat. Sci. and Tech., Okayama Univ., 4CCS, Univ. of
Tsukuba, 5R-CCS, RIKEN, 6Inst. Nanosci. Design, Osaka Univ.)
水・水和／電解質／Water & Hydration & Electrolyte

1Pos100* 生体溶液中のアニオンサイト間実効引力が発生する最大のサイトサイズ
Maximum size for attractive anionic-sites in a biological solution
Michika Takeda1, Ayumi Suematsu2, Ryo Akiyama3 (1Graduate of Science, Kyushu University, 2Kyushu
Sanyo University, 3Institute of Science, Kyushu University)
1Pos101 MD シミュレーションで、モデルタンパク質の水和水のダイナミクスを明らかにする
MD simulations reveal hydration dynamics around model proteins
Takuya Takahashi1, Takuya Azami2, Nobuya Hasegawa1, Ryoi Ashida1,2, Kota Kasahara1 (1Coll. Life Sci.,
Ritsumeikan Univ., 2Grad. Sch. Life Sci., Ritsumeikan Univ)
1Pos102 All-atom molecular dynamics simulation of the reduced protein-protein interaction withmetabolites in the cytoplasm
Isseki Yu1,2, Michael Feig3, Yuji Sugita2 (1Maebashi Institute of Technology, 2RIKEN Theoretical
Molecular Science Lab., 3Michigan State University)
1Pos103 プロテインーリガンド結合における水溶媒の役割
Role of water solvent in protein-ligand binding
Yutaka Maruyama1, Ayori Mitsutake2, Takefumi Yamashita3 (1RIKEN R-CCS, 2Dep. Phys., Meiji Univ.,
3LSBM, Univ. Tokyo)
発生・分化／Development & Differentiation
1Pos104
1Pos105

1Pos106

1Pos107

Mechanical symmetry breaking in C. elegans dorsal-ventral axis establishment
Masatoshi Nishikawa (Dept. Frontier Bioscience, Hosei Univ.)
マウスノード不動繊毛はメカノセンサーか?: 光ピンセットによる機械刺激後の Ca2+応答
Are the immotile nodal cilia in mouse embryo mechanosensors?: Ca2+ signaling response after
mechanical stimulation by optical tweezers
Takanobu A Katoh, Katsutoshi Mizuno, Hiroshi Hamada (BDR, Riken)
ライブセルイメージングが切り開くシアノバクテリアのヘテロシスト分化空間パターン維持機構
Live cell imaging sheds light on the maintenance mechanism of pattern of cyanobacterial celldifferentiation
Shun-ichi Fukushima1, Takeharu Nagai1, Shigeki Ehira2 (1The Institute of Scientific and Industrial
Research, Osaka University, 2Department of Biological Sciences, Graduate School of Science, Tokyo
Metropolitan University)
細胞性粘菌における既知のシグナルを用いない細胞分化状態の検出
Detection of cell differentiation states without known signals in Dictyostelium
Yusuke V. Morimoto1,2, Takuro Kawada1, Masahiro Ueda2,3 (1Fac. Comp. Sci. and Sys. Eng., Kyushu Inst.
Tech., 2BDR, RIKEN, 3Grad. Sch. Frontier Biosci., Osaka Univ.)– S106 –筋肉／Muscle
1Pos108

1Pos109

1Pos110

1Pos111

1Pos112(1SGA-2) 心筋細胞に備わる収縮リズム恒常性の分子機構の解明(1SGA-2) Elucidation of molecular mechanism of contraction rhythm homeostasis in cardiac
myocytes
Seine Shintani1, Takumi Washio2 (1Department of Biomedical Sciences, College of Life and Health
Sciences, Chubu University, 2Graduate School of Frontier Sciences, the University of Tokyo)
トロポニン T の E244D 変異による細いフィラメント構造変化の X 線小角散乱解析
Structural changes of cardiac thin filaments caused by E244D mutation of troponin T observedby small-angle X-ray scattering
Tatsuhito Matsuo, Satoru Fujiwara (Inst. Quant. Life Sci., QST)
分子動力学計算によるミオシンの第二リン酸結合部位の検証
Validation of second phosphate binding site in myosin studied by molecular dynamics
simulation
Kouei Uchida, Jun Ohnuki, Takato Sato, Mitsunori Takano (Dept. of Pure & Appl. Phys., Waseda Univ.)
ミオシンのアクチンに対する結合親和性の低温における弱化を説明するための統計熱力学
Statistical thermodynamics on the weakening of binding affinity of myosin for actin at low
temperatures
Tomohiko Hayashi, Masahiro Kinoshita (Inst. Adv. Energy, Kyoto Univ.)
1 分子・多分子実験から迫る、心機能に適した心筋ミオシンの性質
Reverse stroke of cardiac myosin revealed by single molecule microscopy is essential for heart
function
Yongtae Hwang1, Takumi Washio2, Hideo Higuchi1, Motoshi Kaya1 (1Department of Physics, The
University of Tokyo, 2Department of Human and Engineered Environmental Studies, The University ofTokyo)
分子モーター／Molecular motor

1Pos113* 負荷に依存した細菌べん毛モーター回転速度の調節機構
Load-dependent speed regulation of the bacterial flagellar motor
Tsubasa Ishida1, Myu Yoshida2, Tohru Minamino3, Yoshiyuki Sowa1,2,4 (1Grad. Sch. Sci. & Eng., Hosei
Univ., 2Dept. Frontier Biosci., Hosei Univ., 3Grad. Sch. Frontier Biosci., Osaka Univ., 4Res. Cent. MicroNano Tech., Hosei Univ.)
1Pos114* F1-ATPase の阻害状態解析
Analysis of the inhibited form of F1-ATPase
Sougo Mori, Hiroshi Ueno, Hiroyuki Noji (Noji laboratory, Department of Applied Chemistry, Graduate
School of Engineering, University of Tokyo)
1Pos115* Na+の存在に依存するべん毛モーター固定子 PomAB における複合体の解離
Destabilization of the complex formation allows high Na+ conduction in the PomAB flagellar
stator complex
Tatsuro Nishikino, Hiroto Iwatsuki, Taira Mino, Seiji Kojima, Michio Homma (Div. Biol. Sci. Grad. Sch.
Sci., Nagoya Univ.)
1Pos116* Biomolecular motor driven cargo transportation by microtubules as a mechanosensor
Syeda Rubaiya Nasrin1, Arif Md. Rashedul Kabir2, Kazuki Sada1,2, Akira Kakugo1,2 (1Grad. Sch. Chem.
Sci. and Engg., Hokkaido Univ., 2Fac. Sci., Hokkaido Univ.)
1Pos117* ハイブリッド F1-ATPase の 1 分子回転観察
Rotation observation of hybrid F1-ATPases between bacterial and mammalian ones
Ryo Watanabe1, Hiroshi Ueno1, Toshiharu Suzuki2, Ryohei Kobayashi1, Hiroyuki Noji1 (1Appl. Chem.,
Grad. Sch. Eng., Univ. Tokyo, 2CLS., Tokyo tech.)– S107 –1Pos118* 生体分子群ロボットによる光制御時空間貨物輸送
Photo-regulated spatiotemporal cargo transportation by biomolecular swarm robot
Mousumi Akter1, Jakia Jannat Keya2, Arif Md. Rashedul Kabir2, Hiroyuki Asanuma3, Kuzuya Akinori4,
Kazuki Sada1,2, Akira Kakugo1,2 (1Graduate School of Chemical Science and Engineering, Hokkaido
University, Sapporo 060-0810, Japan, 2Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan,
3Department of Biomolecular Engineering, Nagoya University, Nagoya, Japan, 4Department of Chemistry
and Materials Engineering, Kansai University, Osaka 564-8680, Japan)
1Pos119* べん毛モーターの分子軸受 LP リングのクライオ電子顕微鏡による構造解析
CryoEM structural analysis of the bacterial flagellar LP ring ~ a molecular bushing of thebacterial motor with almost no friction ~Tomoko Yamaguchi1,2, Fumiaki Makino1,3, Tomoko Miyata1, Takayuki Kato1, Keiichi Namba1,2,4 (1Grad.
Sch. FBS, Univ. Osaka, 2BDR, Riken, 3JEOL Ltd., 4Spring-8, Riken)
1Pos120 べん毛フックの自然な構造
Structure of the native supercoiled flagellar hook
Takayuki Kato1, Tomoko Miyata1, Fumiaki Makino1,2, Peter Horvath1, Keiichi Namba1,3 (1Front. Bio.,
Osaka univ., 2JEOL, 3BDR, Riken)
1Pos121 細菌べん毛基部体の極低温電子顕微鏡による構造解析
Structure analysis of the bacterial flagellar basal body by electron microscopy
Tomoko Miyata1, Takayuki Kato1, Fumiaki Makino1,2, Yumiko Saijo3, Keiichi Namba1,4 (1Grad. Sch.
Frontier Biosci., Osaka Univ., 2JEOL Ltd, 3Grad. Sch. Med., Kobe Univ., 4BDR&SPring8, RIKEN)
1Pos122 Structure of motor evolved by combination of F-ATPase and phosphoglycerate kinase for
Mycoplasma mobile gliding
Takuma Toyonaga1, Takayuki Kato2, Akihiro Kawamoto3, Tasuku Hamaguchi4, Keiichi Namba2,4,5,
Makoto Miyata1,6 (1Grad. Sch. Sci., Osaka City Univ., 2Grad. Sch. Front. Biosci., Osaka Univ., 3IPR, Osaka
Univ., 4SPring-8, RIKEN, 5BDR, RIKEN, 6OCARINA, Osaka City Univ.)
1Pos123 コンデンシン分子モーターの DNA カーテン測定と構造モデリングDNA curtain assay and structural modeling of condensin molecular motor
Hiroki Koide, Shoji Takada, Tsuyoshi Terakawa (Dept Biophysics, Div Biology, Grad School Science,
Kyoto University)
1Pos124 nanodisc-Vo の再構成条件検討と単粒子解析
The Investigation of reconstruction and Single Particle Analysis of nanodisc-Vo
Aya Furuta1, Jun-ichi Kishikawa1, Takayuki Kato2, Atsuko Nakanishi1, Kaoru Mitsuoka3, Ken Yokoyama1(1Div. Life Sci., Kyoto Sangyo Univ., 2Grad. Sch. Frontier Biosci.,Osaka Univ., 3Res. Ctr. UHVEM., Osaka
Univ.)
1Pos125 クシクラゲの櫛板はシンクロトロン放射光による繊毛軸糸の構造・機能解析に最適な試料である
Synchrotron radiation X-ray diffractionv reveals the highly ordered structure of axonemes in the
comb plate of ctenophores
Hiroyuki Iwamoto1, Kei Jokura2, Kazuo Inaba2 (1SPring-8, JASRI, 2Shimoda Marine Res. Ctr., Univ.
Tsukuba)
1Pos126 Unidirectional-rotation and helical-motion of a cargo on a microtubule indicate torque generation
and biased sideward binding of kinesin
Mitsuhiro Sugawa, Yohei Maruyama, Masahiko Yamagishi, Junichiro Yajima (Grad. Sch. Arts andSciences, Univ. Tokyo)
1Pos127 ウシミトコンドリア由来 F1-ATPase の 1 分子回転解析
Single-molecule analysis of bovine mitochondrial F1-ATPase
Ryohei Kobayashi, Hiroshi Ueno, Hiroyuki Noji (Appl. Chem., Grad. Sch. Eng., Univ. Tokyo)
1Pos128 二つの頭部のつながり方がミオシン VI の歩行運動に与える影響
Effects of interhead connection on the stepping motion of myosin VI
Tomoki P. Terada1, Qing-Miao Nie2, Masaki Sasai1 (1Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.,
2Dept. Appl. Phys., Zhejiang Univ. Tech.)– S108 –1Pos129

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1Pos1311Pos132

1Pos133

1Pos134

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1Pos137

1Pos138

Allosteric Regulation of V1-ATPase by Designing Non-catalytic Interface
Takahiro Kosugi1,2,3, Tatsuya Iida2, Mikio Tanabe4, Ryota Iino1,2, Nobuyasu Koga1,2,3 (1Institute for
Molecular Science, 2SOKENDAI, 3ExCELLS, 4KEK)
キネシン-1 人工多量体のプロセシビティと一方向運動性の評価
Evaluation of processivity and unidirectionality of artificial kinesin-1 oligomers
Kimitoshi Takeda, Akihiko Nakamura, Jun Ando, Ryota Iino (Institute for Molecular Science)
DNA ナノフィラメント上を移動する改変型ダイニンを用いた人工輸送システムの創生
Creating artificial transport systems by using engineered dynein that moves along DNA
nanofilament
Ryota Ibusuki1, Tatsuya Morishita1, Akane Furuta2, Kazuhiro Oiwa1,2, Hiroaki Kojima2, Ken'ya Furuta2(1Grad. Sch. Sci., Univ. Hyogo, 2Adv. ICR. Res. Ins., NICT. Kobe)
DNA 上を動く改変ダイニンを用いて結合性と運動速度の関係を系統的に調べる
Systematic studies on the relation between binding kinetics and speed of movement using
engineered DNA-based dynein motor
Tatsuya Morishita1, Ryota Ibusuki1, Akane Furuta2, Kazuhiro Oiwa1,2, Hiroaki Kojima2, Ken'ya Furuta2(1Grad. Sch. Sci., Univ. Hyogo, 2Adv. ICT Res. Inst NICT)Fo 回転モーターにおける固定子－回転子間相互作用の自由エネルギー地形
Free energy landscape for stator-rotor interaction in Fo rotary motor
Dan Parkin, Daiki Yamakoshi, Genya Nakagawa, Mitsunori Takano (Dept. of Pure & Appl. Phys., Waseda
Univ.)
ミオシン頭部の自由エネルギーランドスケープのスイッチングを考慮した筋収縮の三状態モデル
Three-state model of muscle contraction with switched free energy landscapes for myosin
heads
Kaima Matsuda, Masaki Sasai, Tomoki P. Terada (Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.)
DNA オリガミを用いたミオシンフィラメントでのミオシン II モーターの高速原子間力顕微鏡による同時観察
Simultaneous observation of individual myosin II motors in DNA origami-based thick filaments
by high-speed AFM
Masashi Ohmachi1, Hiroaki Takagi2, Keigo Ikezaki3, Toshio Yanagida1,4, Mitsuhiro Iwaki1,4 (1BDR,
RIKEN, 2Nara Med. Univ., 3Univ. Tokyo, 4Grad. Sch. Front. Biosci., Osaka Univ.)
アクトミオシン運動に対するリゾチームの阻害作用
Inhibitory effect of lysozyme on the motility of actomyosin
Masaki Okami, Kuniyuki Hatori (Grad.Sch.Sci.Eng., Yamagata Univ.)
ダイナクチンサイドアームのコンフォメーション変化
Multiple conformational changes of dynactin sidearm revealed by single molecule observation
Kei Saito1, Takuya Kobayashi2, Takashi Murayama2, Mitsuhiro Sugawa1, Christian Ganser3,
Takayuki Uchihashi3,4, Junichiro Yajima1, Yoko Y. Toyoshima1 (1Grad. Sch. Arts Sci., Univ. Tokyo, 2Dept.
of Pharmacology, Juntendo Univ. Sch. of Med., 3NINS, ExCELLS, 4Dept. of Phys., Nagoya Univ.)
The contribution of microtubule-binding ability of dynactin in dynein behaviors on microtubules
Takuya Kobayashi1, Kei Saito2, Takuya Miyashita2, Yoko Y Toyoshima2, Takashi Murayama1 (1Dept.
Pharmacology, Juntendo Univ., 2Grad. sch. Arts and Sci. Univ. Tokyo)
細胞生物的課題／Cell biology

1Pos139* (3SDA-6) 集団細胞遊走における機械的なシグナルを介した ERK 活性伝播
(3SDA-6) ERK activation waves mediated by intercellular mechanical signals during collective
cell migration
Naoya Hino1, Xavier Trepat2, Michiyuki Matsuda1,3, Tsuyoshi Hirashima3 (1Grad. Sch. of Biostudies,
Kyoto Univ., 2IBEC, Spain, 3Grad. Sch. of Med., Kyoto Univ.)– S109 –1Pos140* スピロプラズマの螺旋交換遊泳を駆動する内部リボン構造
Internal ribbon structure driving helicity-switching swimming of Spiroplasma
Yuya Sasajima1, Takayuki Kato2, Tomoko Miyata2, Keiishi Namba2,3, Makoto Miyata1,4 (1Grad. Sch. Sci.,
Osaka City Univ., Japan, 2Grad. Sch. Front. Biosci., Osaka Univ., Japan, 3BDR & SPring-8 Center, Riken,
Japan, 4OCARINA, Osaka City Univ., Japan)
1Pos141* 液-液相分離における荷電性残基の影響に関する分子動力学シミュレーション
Molecular dynamics simulations to dissect effects of charged residues on liquid-liquid phaseseparation
Hiroki Terazawa1, Kota Kasahara2, Takuya Takahashi2 (1Grad. Sch. Life Sci., Ritsumeikan Univ., 2Coll.
Life Sci., Ritsumeikan Univ.)
1Pos142* Spiroplasma eriocheiris の遊泳運動にかかわる細菌のアクチン MreB の重合
Polymerization of bacterial actin MreB involved in swimming motility of Spiroplasma eriocheiris
Daichi Takahashi1, Makoto Miyata1,2 (1Grad. Sch. Sci, Osaka City Univ., 2OCARINA, Osaka City Univ.)
1Pos143* クラミドモナス細胞の鞭毛打頻度を用いた細胞内 ATP 濃度の推定
Estimation of intracellular ATP concentration from the flagellar beat frequency inChlamydomonas
Wakako Takano1,2, Toru Hisabori1,2, Ken-ichi Wakabayashi1,2 (1CLS, Tokyo Tech, 2LST, Tokyo Tech)
1Pos144* 細菌バイオフィムの高次秩序構造
High structural order in bacteria biofilms
Kohei Takahashi1, Kana Morinaga1,2, Masanonri Toyofuku3,4, Utada Andrew3,4 (1Graduate school of Lifeand Environment Science, University of Tsukuba, 2Bioproduction Research Institute, Advanced Industrial
Science and Technology, 3Faculty Life Environment Science, University of Tsukuba, 4Microbiology
Research Center for Sustainability (MiCS), University of Tsukuba)
1Pos145* 合成細菌における Spiroplasma eriocheiris 遊泳運動の再現
Reconstitution of Spiroplasma eriocheiris swimming motility in a synthetic bacterium
Hana Kiyama1, Shigeyuki Kakizawa2, Makoto Miyata1,3 (1Grad. Sch. Sci., Osaka City Univ.,
2AIST,Bioprocess, 3OCARINA, Osaka City Univ.)
1Pos146 (1SHA-3) Direct observation of cell mechanics under high hydrostatic pressure
Masatoshi Morimatsu, Keiji Naruse (Grad. Sch. of Med., Dent. and Pharma. Sci., Okayama Univ.)
1Pos147 (1SHA-2) RhoA activation induces cell cycle exit and differentiation of skin cancer cells
Oleg Dobrokhotov, Masahiro Sokabe, Hiroaki Hirata (Nagoya Univ., Grad. Sch. Med.)
1Pos148 ゼブラフィッシュ胚上皮組織に内在する力が創傷治癒を制御する
Residual Stress-mediated wound healing in zebrafish epithelia
Sohei Yamada1, Yasumasa Bessho2, Yoichiroh Hosokawa1, Takaaki Matsui2 (1Division of Materials
Science, Nara Institute of Science and Technology, 2Division of Biological Science, Nara Institute of
Science and Technology)
1Pos149 TIRF 観察によるアクチン重合・脱重合における蛍光標識の影響
Effects of Dye Labels on Actin Assembly and Disassembly
Ikuko Fujiwara1, Shuichi Takeda2, Toshiro Oda5, Thomas Pollard3, Naomi Courtemanche4,
Akihiro Narita2, Yuichiro Maeda2 (1Grad.Sch.Sci., Osaka City Univ., 2Structural Biol. Res. Cent. Gad.
Sch.Sci., Nagoya Univ., 3MCDB, Yale Univ., USA, 4Univ. Minnesota, USA, 5Tokaigakuin Univ.)
1Pos150 変異リアノジン受容体の分子動力学シミュレーション
Molecular dynamics simulation of mutant ryanodine receptors
Toshiko Yamazawa1, Haruo Ogawa2, Maki Yamaguchi1, Takashi Murayama3, Hideto Oyamada4,
Nagomi Kurebayashi3, Junji Suzuki5, Kazunori Kanemaru6, Katsuji Oguchi4, Takashi Sakurai3,
Masamitsu Iino6 (1Dept Mol. Physiol., Jikei Univ. Sch. Med., 2Institute Quantitative Biosci., The
Univ.Tokyo, 3Dept. Pharmacol., Juntendo Univ. Sch. Med., 4Dept. Pharmacol., Sch. Med., Showa Univ,
5Dept. Physiol., Univ. California San Francisco, 6Dept. Cell. Mol. Pharmacol., Nihon Univ. Sch. Med.)– S110 –1Pos151

1Pos152

1Pos153

1Pos154

1Pos155

1Pos156

1Pos157

1Pos158

1Pos159

1Pos160

1Pos161

1Pos162

1Pos163

脱重合が引き起こす接着斑周囲におけるアクチン細胞骨格の向きの変化
The change of the direction of F-actin caused by the filament disassembly around focal
adhesions
Kiyoshi Tohyama1, Sawako Yamashiro2, Naoki Watanabe1,2 (1Department of Pharmacology, Kyoto
University Faculty of Medicine, 2Laboratory of Single-Molecule Cell Biology, Kyoto University Graduate
School of Biostudies)
クラミドモナス鞭毛の根元に局在するマイナータイプダイニンの機能解析
Functional analysis of minor-type axonemal dyneins located to the basal region ofChlamydomonas flagella
Tomohiro Komatsu, Yusuke Kondoh, Toshiki Yagi (Dept. Life Sci., Pref. Univ. Hiroshima)
共焦点レーザー走査型顕微鏡で捉えた軸索タンパクのブラウン運動
Brownian motions of axonal proteins captured by a confocal laser scanning microscopy
Kazunari Mouri1, Yasushi Okada1,2 (1RIKEN, BDR, 2Univ. Tokyo, Grad. Sch. Sci., Dept. Phys.)
生体内光架橋によるべん毛回転子タンパク質 FliG と固定子タンパク質 PomA 間相互作用の検出
Interaction between the flagellar rotor protein FliG and the stator protein PomA in cells detectedby in vivo photo-crosslink
Seiji Kojima, Hiroyuki Terashima, Michio Homma (Div. Biol. Sci., Grad. Sch. Sci., Nagoya University)
ケラトサイトの回転するストレスファイバ車輪の内側の核と外側の細胞膜の動き
Movement of inner nucleus and outer cell membrane of a rotating stress fiber-wheel in a
migrating keratocyte
Chika Okimura, Yoshiaki Iwadate (Fac. Sci., Yamaguchi Univ.)
バクテリアべん毛タンパク質輸送装置のゲート機構
Gating mechanism of the bacterial flagellar protein export apparatus
Miki Kinoshita1, Keiichi Namba1,2,3, Tohru Minamino1 (1Grad. Sch. Frontier Biosci, Osaka Univ.,
2RIKEN, Spring-8, 3RIKEN, BDR)
スピロヘータの遊泳におけるべん毛回転と細胞形状の関係
Relationship between the flagellar rotation and cell shape in a swimming spirochete
Toshiki Kuribayashi, Shuichi Nakamura (Grad. Sch. Eng., Tohoku Univ.)
正のべん毛本数制御因子 FlhF は MS リング構成因子 FliF の極局在を促進する
The polar localization of FliF, composing MS-ring, is promoted by FlhF in Vibrio alginolyticus
Yuna Inoue, Seiji Kojima, Keiichi Hirano, Hiroyuki Terashima, Michio Homma (Division of Biological
Science, Graduate School of Science, Nagoya University)
超解像顕微鏡法と単粒子追跡法による標的細胞へのエクソソーム取り込み機構の解明
Uptake mechanism of exosomes by target cells as revealed by super-resolution microscopy andsingle-particle tracking
Koichiro M. Hirosawa1, Taka A. Tsunoyama2, Yasunari Yokota3, Kenichi G. N. Suzuki1,4 (1G-CHAIN,
Gifu Univ., 2OIST, 3Information Science, Gifu University, 4JST-CREST)
ミトコンドリアの形態と活性の間に相関はあるか？
Are there any correlations between the morphology and the activity of mitochondria?
Arima Okutani (Tokyo University of Agriculture and Technology)
酸素への電子伝達阻害時のミトコンドリアの分極機構
Mitochondrial polarization upon inhibition of electron transfer to oxygen
Hinako Tanaka1, Emika Shida1, Ikuroh Ohsawa2, Yoshihiro Ohta1 (1Grad. Sch. Biotech., TUAT,
2Bioregulatory function., TMGH)
Single-molecule imaging of PI3K in eukaryotic motile cell
Satomi Matsuoka1,2,3, Seiya Fukushima1, Masahiro Ueda1,2 (1Graduate School of Frontier Biosciences,
Osaka University, 2Center for Biosystems Dynamics Research, RIKEN, 3PRESTO, JST)
温度条件に依存して変化する、大腸菌走化性適応過程の定量解析
Quantitative analysis of E. coli chemotaxis adaptation process that changes depending on
temperature conditions
Hiroto Tanaka, Yasuaki Kazuta, Hiroaki Kojima (Adv ICT Res Inst, NICT)– S111 –1Pos164

1Pos165

1Pos166

細胞辺縁での Aβ の凝集は細胞運動を抑制した
Aggregation of Aβ at the cell periphery suppressed cell motility
Yusaku Chikai, Ryota Yamashita, Masahiro Kuragano, Kiyotaka Tokuraku (Grad. Sch. Eng., MuroranInst. Tech.)Mechanisms of negative gravitaxis in free-swimming Chlamydomonas reinhardtii
Azusa Kage1, Toshihiro Omori2 (1Dept. Mech. Eng., Toyohashi U. Tech., 2Dept. Finemechanics, Tohoku
U.)
孤立した MDCK 細胞における形態および運動の多様性
Diversity in morphological and motile patterns of isolated MDCK epithelial cells
Shimon Shibagaki1, Shota Mise1, Seiya Nishikawa1, Hiroko Nakamura2, Hiroshi Kimura2,
Atsuko Takamatsu1 (1Dept. of Elec., Eng. & Biosci., Waseda Univ., 2Dept. of Mecha., Tokai Univ.)
生体膜・人工膜／Biological & Artificial membrane: Structure & Property

1Pos167* リン脂質スクランブラーゼ XKR による昆虫細胞膜の高粘弾性変形能
Enhanced viscoelastic deformation of insect cell membrane by phospholipid scramblase XKR
Akifumi Shiomi1, Kohjiro Nagao1, Akihisa Yamamoto2, Ryo Suzuki2, Motomu Tanaka2, Masato Umeda1(1Grad. Sch. Eng., Kyoto Univ., 2Inst. Adv. Stud., Kyoto Univ.)
1Pos168* ピコ秒時間分解けい光分光法で評価した膜標的薬物の人工脂質二重膜への影響
Effect of membrane-targeted drugs on artificial lipid bilayer membranes evaluated bypicosecond time-resolved fluorescence spectroscopy
Natsumi Okada1, Masayuki Iwamoto2, Haruna Hayashi1, Akira Takakado1, Shigetoshi Oiki3,
Koichi Iwata1 (1Faculty of Science, Gakushuin University, 2Faculty of Medical Sciences, University of
Fukui, 3Biomedical Imaging Research Center, University of Fukui)
1Pos169* ボトムアップ配列設計による α-ヘリックスペプチドナノポアの構築
De novo design for pore-forming peptides with α-helical structure
Masataka Usami, Keisuke Shimizu, Yusuke Sekiya, Ryuji Kawano (Tokyo University of Agriculture andTechnology)
1Pos170* 脂質膜中にナノポアを構築する β シートペプチドの De novo 配列設計
De novo design of nanopore-forming β-sheet peptide in bilayer lipid membrane
Keisuke Shimizu1, Shungo Sakashita2, Yoshio Hamada2, Kenji Usui2, Batsaikhan Mijiddorj3,
Izuru Kawamura1, Ryuji Kawano1 (1Department of Biotechnology and Life Science, Tokyo University ofAgriculture and Technology, 2Faculty of Frontiers of Innovative Research in Science and Technology,
Konan University, 3Department of Materials Science and Engineering, Yokohama National University)
1Pos171* Investigation of local anesthetic and membrane interactions using model cell membranes
Wanjae Choi1, Hyunil Ryu1, Seulmini Goh1, Chaoge Zhou1, Soonjo Kwon1, Sun Min Kim2,
Tae-Joon Jeon1 (1Department of Biological Engineering, Inha University, Incheon, 2Department of
Mechanical Engineering, Inha University, Incheon)
1Pos172 環状ジペプチドの安定構造における系統的な傾向と特徴
Systematic trends and features in the stable structure of cyclic dipeptides
Koki Yanagi1,2, Hiroaki Nishizawa2, Ryunosuke Yoshino2, Ryuhei Harada2, Yasuteru Shigeta2 (1Phys.,
Pure and Applied Sci., Grad. Sch. Univ. Tsukuba, 2CCS, Univ. Tsukuba)
1Pos173 Ca2+-dependent high-conductance channel activity of F-ATP synthase matches thepermeability transition pore
Andrea Urbani1,2,5,6, Valentina Giorgio2, Andrea Carrer2, Cinzia Franchin2, Giorgio Arrigoni2,
Chimari Jiko3, Kazuhiro Abe7, Janna F.M. Bogers4, Shintaro Maeda6, Kyoko Shinzawa5,
Christoph Gerle1, Ildiko Szabo2, Paolo Bernardi2 (1IPR, 2Univ. Padova, 3Kyoto Univ., 4TU Delft, 5Univ.
Hyogo, 6Scripps, 7Nagoya Univ.)– S112 –1Pos174

1Pos175

1Pos1761Pos177

1Pos178

1Pos179

1Pos180

1Pos1811Pos182

1Pos183

1Pos184

1Pos185

P-SPICA: A coarse-grained force field for biological systems with a polar coarse-grained watermodel
Yusuke Miyazaki, Susumu Okazaki, Wataru Shinoda (Grad. Sch. Eng., Nagoya Univ.)
光照射によるリポソーム内への配列選択的 DNA 輸送
Sequence selective DNA transport into liposome by photoirradiation
Shigetaka Nakamura, Nobuharu Uehara, Takashi Hasegawa, Kenzo Fujimoto (JAIST)
生細胞膜上における相分離の誘発と可逆的制御
Induction and reversible control of phase separation on living cell membranes
Kenichi Kawano1, Yasufumi Takahashi2, Ryo Ohtani3, Masanao Kinoshita4, Shiroh Futaki1 (1Institute for
Chemical Research, Kyoto University, 2WPI-NanoLSI, Kanazawa University, 3Department of Chemistry,
Faculty of Science, Kyushu University, 4Graduate School of Science, Kyushu University)
気液界面における人工肺サーファクタント膜への微粒子の影響
Effect of sub-micron particles on a model lung surfactant monolayer at the air-water interface
Masahiro Hibino1, Toshiki Kamata2 (1Div. Sust. Enviro. Eng., Muroran Inst. Tech., 2Dept. Appl. Sci.,
Muroran Inst. Tech.)On the condensing effects of 7β-hydroxycholesterol, 25-hydroxycholesterol, and cholesterol on
DPPC bilayers
Hiroshi Takahashi, Tatsuya Hoshino (Biophys. Lab., Grad. Sch. Sci.&Tech., Gunma Univ.)
蛍光寿命測定を用いた脂質二重膜におけるセラミド-1-リン酸の動的挙動解析
Dynamic behavior of ceramide-1-phosphate in lipid bilayers examined by fluorescence lifetime
measurement
Tomokazu Yasuda1,2, J. Peter Slotte3 (1Grad. Sch. Sci., Osaka Univ., 2Research Foundation Itsuu
Laboratory, 3Åbo Akademi Univ.)
Molecular dynamics simulation of the mechanical properties of lipid membranes in the presenceof proteins
Diego Ugarte, Shoji Takada (Takada Lab., Dept. Biophysics, Div. Biology, Grad. Sch. of Sci., Kyoto Univ.)
EGFR 膜近傍領域のリン酸化が EGFR TM-JM 二量体構造に及ぼす影響
The impact of phosphorylation in the EGFR JM region on the dimer structure of EGFR TM-JM
regionDaisuke Matsuoka1, Yuji Sugita1,2,3 (1RIKEN Theoretical Molecular Science, 2RIKEN R-CCS, 3RIKEN
BDR)The dipole potential probed by hydrophobic ions using the contact bubble bilayer method
Yuka Matsuki1, Masayuki Iwamoto2, Mariko Yamatake2, Shigetoshi Oiki3 (1Dept. Anesth & Reanmat.,Univ. Fukui Facult. Med. Sci., 2Dept. Mol. Neurosci., Univ. Fukui Facult. Med. Sci., 3Biomed. Imaging Res.
Center, Univ. Fukui)
膜活性な両親媒性ランダムコポリマーによる脂質ナノディスクの自発形成
Spontaneous formation of lipid nanodisc by membrane active amphiphilic random copolymer
Kazuma Yasuhara, Mitsuyoshi Yuma, Jinyu Hao, Jin Arakida, Rapenne Gwenael, Jun-ichi Kikuchi (Div.
Mater. Sci., Nara Inst. Sci. Tech.)
動的および静的光散乱法によるリン脂質ベシクルの構造評価 2
Structural evaluation of phospholipid vesicles by dynamic and static light scattering techniques
2
Nobutake Tamai1, Takeshi Nobuoka2, Ryo Takechi2, Masaki Goto1, Hitoshi Matsuki1 (1Grad. Sch. Tech.
Indus. Soc. Sci., Tokushima Univ., 2Dept. Biol. Tech. Sci., Col. Eng., Tokushima Univ.)
脂質膜外葉のみに形成したラフト様秩序領域の物性とそれが内葉に及ぼす影響
Physicochemical properties of raft-like ordered domains formed in outer leaflet and its influenceon the inner leaflet
Takuya Koga, Masanao Kinoshita, Nobuaki Matsumori (Grad. Sch. Sci., Kyushu Univ.)– S113 –1Pos186

1Pos187

1Pos188

三種のリン脂質/コレステロール・リポソームにおけるクロルゾキサゾン捕捉量とコレステロール
濃度との相関Correlation between the amount of trap of chlorzoxazone by various phospholipid/cholesterol
liposomes and their cholesterol concentrations
Shosei Kano, Hiroshi Takahashi (Biophys. Lab., Grad. Sch. Sci.&Tech., Gunma Univ.)
ジミリストイルホスファチジルコリン 2 重膜に形成された脂質様錯体ドメインの物理化学的特性
Physico-chemical properties of lipophilic complex-rich domains formed indimyistoylphosphatidylcholine (DMPC) bilayers
Hikaru Watanabe, Yoshinao Kinoshita, Ryo Ohtani, Nobuaki Matsumori (Grad. Sch. Sci., Kyushu Univ.)
低流量電子線散乱法を用いた局所的な脂質充填構造の解析
Low-flux election-diffraction discloses the local structure of lipid membrane
Shimpei Yamaguchi, Masanao Kinoshita, Nobuaki Matsumori (Grad. Sch. Sci., Kyushu Univ.)
化学受容／Chemoreception

1Pos189* 全反射赤外分光法によるムスカリン性アセチルコリン M2 受容体のリガンド認識、活性化機構研究
Ligand recognition and activation mechanism in muscarinic acetylcholine receptor M2 (M2R)
study by ATR-FTIR spectroscopy
Kohei Suzuki1, Kodai Katayama1, Ryoji Suno2, Hideki Kandori1 (1Nagoya Institute of Technology, 2Kansai
Medical University)
1Pos190 コレラ菌タウリン走性受容体 Mlp37 の制御ネットワーク
The regulatory network controls expression of the taurine chemoreceptor Mlp37 in Vibrio
cholerae
So-ichiro Nishiyama1, Hirotaka Tajima2,3, Shiori Onogi2, Hiroshi Urakami1, Ikuro Kawagishi2,3 (1Fac.
App. Life Sci., Niigata Univ. Pharm. App. Life Sci., 2Dept. Frontier Biosci., Hosei Univ., 3Res. Cen. MicroNano Tech., Hosei Univ.)
1Pos191 大腸菌グローバル転写因子 PdhR による走化性受容体遺伝子発現調節
Expression of the major chemoreceptor genes is regulated by a global transcription factor PdhR
in Escherichia coli
Ayano Inoue1, Nana Ito1, Yumeno Kawasaki1, Eri Shiokawa1, Hirotaka Tajima2,3, Ikuro Kawagishi1,2,3(1Grad. Sch.Sci.&Eng., Hosei Univ., 2Dept. Frontier Biosci., Hosei Univ., 3Res. Cen. Micro-Nano Tech.,Hosei Univ.)
1Pos192 大腸菌細胞側面膜領域における走化性受容体クラスター形成
Chemoreceptor clustering of Escherichia coli in lateral regions of the cytoplasmic membrane
Nana Ito1, Masatoshi Nishikawa2, Yoshiyuki Sowa1,2,3, Ikuro Kawagishi1,2,3 (1Grad. Sch. Sci. & Eng.,
Hosei Univ., 2Dept. Frontier Biosci., Hosei Univ., 3Res. Cen. Micro-Nano Tech., Hosei Univ.)
1Pos193 細菌の可溶性走化性受容体と細胞膜貫通型走化性トランスデューサー相互作用解析
Probing interaction between a soluble receptor and a transmembrane transducer in bacterial
chemotaxis
Hisashi Kubota1, Kana Murakami2, Hirotaka Tajima2,3, Ikuro Kawagishi1,2,3 (1Grad. Sch. Sci. & Eng.,
Hosei Univ., 2Dept. Frontier Biosci., Hosei Univ., 3Res. Cen. Micro-Nano Tech., Hosei Univ.)
神経・感覚／Neuroscience & Sensory systems
1Pos194* 脳脊髄液流動を想定した非平衡空間におけるアミロイド β 凝集
Amyloid β Aggregation in Non-equilibrium Space Mimicking Cerebrospinal Fluidic Flow
Akane Iida1, Kei Unoura2, Hideki Nabika2 (1Graduate School of Sci. and Eng., Yamagata Univ., 2Facultyof Sci., Yamagata Univ.)– S114 –1Pos195* 光ピンセットを用いた AMPA 型グルタミン酸受容体分子操作における神経電気活動変化
Neuronal electrical activity induced by optical trapping of AMPA-type glutamate receptors on
neurons
Tatsunori Kishimoto1,2, Suguru Kudoh2, Takahisa Taguchi3, Chie Hosokawa1,2,4 (1Grad. Sch. Sci., Univ.
Osaka City, 2Grad. Sch. Sci. Tech., Univ. Kwansei Gakuin, 3NICT,CiNet, 4PhotoBIO-OIL, AIST-Osaka
Univ.)
1Pos196 (1SEP-2) Single-cell trajectory analysis of human iPS cell-derived neurons carrying a rare
RELN deletion
Yuko Arioka1,2,3, Emiko Shishido1,4, Norio Ozaki1 (1Department of Psychiatry, Nagoya University
Graduate School of Medicine, 2Nagoya University Hospital, 3Institute for Advanced Research, Nagoya
University, 4National Institute for Physiological Sciences)1Pos197 ミミズの短期記憶メカニズム
Molecular mechanism of short-term memory formation in earthworms
Yoshiichiro Kitamura, Akira Sakane, Hikaru Tsumita (Department of Mathematical Sciences and Physics,
College of Science and Engineering, Kanto Gakuin University)
神経回路・脳の情報処理／Neuronal circuit & Information processing
1Pos198* 時間依存性の環境変化認識のモデリング：光結合する矩形波発振子のネットワークがもたらす幾
何学的フラストレーション
Perception of time-dependent environmental change: A toy model with photo-coupled electronic
oscillators composing frustrated network
Hiroshi Ueno, Masatomo Matsushima (Dep. Med. Info., Grad. Sch. Life Med. Sci., Doshisha Univ.)
1Pos199 大脳皮質神経細胞の単一配置による神経回路の構築
Construction of neural network with arrangement of single cerebral cortical neuron
Hayato Toriumi, Tomoyuki Kaneko (LaRC,FB,Hosei Univ)
1Pos200 緑茶由来カテキンはナメクジの匂い嫌悪条件付け学習による記憶形成を強化する
Green tea-derived catechins enhance the long-term memory formation for an odor-aversive
conditioning in the land slug
Yoshimasa Komatsuzaki1, Keisuke Matsui2, Kyouka Ishizuka1, Kouki Tezuka1, Ken Lukowiak3,
Minoru Saito4 (1CST, Nihon Univ., 2Grad. Sch. of Sci. and Tech., Nihon Univ., 3Hotchkiss Brain Inst., Fac.
Med., Univ. Calgary, 4Dept. Biosci., Coll. Hum. Sci., Nihon Univ.)
1Pos201 Sites for formation and storage of associative motor memory revealed by reversible expressionof metabotropic glutamate receptor 1
Yasushi Kishimoto1, Harumi Nakao2, Kouichi Hashimoto3, Kazuo Kitamura4, Miwako Yamasaki5,
Kazuki Nakao2, Masahiko Watanabe5, Masanobu Kano6, Atsu Aiba2, Yutaka Kirino1 (1Kagawa. Sch.
Pharm. Sci., Tokushima Bunri Univ., 2Cent. Dis. Biol. Integr. Med., Univ. Tokyo, 3Sch. Med., Hiroshima
Univ., 4Sch. Med., Univ. Yamanashi, 5Sch. Med., Hokkaido Univ., 6Sch. Med., Univ. Tokyo)
光生物学：視覚・光受容／Photobiology: Vision & Photoreception
1Pos202* 光センサー LOV2 ドメインの光反応中間体の構造揺らぎ検出
Time-resolved study on structural fluctuations of transient intermediates of the light sensor
LOV2 domain
Shunrou Tokonami, Yusuke Nakasone, Masahide Terazima (Dep. Chem., Sch. Sci., Kyoto Univ.)
1Pos203* LOV ドメイン型光活性化アデニル酸シクラーゼ mPAC の光反応ダイナミクス
Photoreaction dynamics of LOV-domain-regulated photoactivated adenylate cyclase mPAC
Misato Ikoma, Yusuke Nakasone, Masahide Terazima (Grad. Sch. Sci., Univ. Kyoto)– S115 –1Pos204* 光センサータンパク質 PYP と下流分子 PBP による励起波長依存的な会合・解離反応ダイナミクス
Excitation wavelength-dependent association and dissociation dynamics between light sensor
protein PYP and its downstream protein PBP
Suhyang Kim1, Yusuke Nakasone1, Akira Takakado2, Yoichi Yamazaki3, Hironari Kamikubo3,
Masahide Terazima1 (1Grad. Sch. Sci., Univ. Kyoto, 2Grad. Sch. Sci., Univ. Gakushuin, 3Div. Mat. Sci.,
NAIST)
1Pos205* TG 法を用いた OCP と FRP の時間分解相互作用ダイナミクスの検出
Detection of time-resolved interaction between OCP and FRP by using transient grating method
Takatoshi Ohata, Yusuke Nakasone, Masahide Terazima (Grad. Sch. Sci., Univ. Kyoto)
1Pos206* 固体 NMR による KR2 のレチナール結合ポケットと Na+結合サイト間の水素結合ネットワークの構造解析
Structural analysis of hydrogen-bond networks between retinal binding pocket and Na+ bindingsite on KR2 by solid-state NMR
Rina Kaneko1, Arisu Shigeta2, Toshio Nagashima3, Toshio Yamazaki3, Keiichi Inoue4,5, Hideki Kandori5,
Izuru Kawamura1,2 (1Grad. Sch. Eng. Sci., Yokohama National Univ., 2Grad. Sch. Eng., Yokohama National
Univ., 3RIKEN, 4Univ. Tokyo, 5Nagoya Inst. Tech.)
1Pos207 SEC-SAXS 法によるシロイヌナズナ由来フィトクロム B の構造解析
Structural analysis of Arabidopsis phytochrome B by small-angle X-ray scattering coupled withsize-exclusion chromatography
Mao Oide1,2, Takaaki Hikima2, Tomotaka Oroguchi1,2, Takayuki Kato3, Yuki Yamaguchi1,2,
Shizue Yoshihara4, Masaki Yamamoto2, Masayoshi Nakasako1,2, Koji Okajima1,2 (1Grad. Sci. Tech., Keio
Univ., 2RIKEN SPring-8 center, 3Grad. Sci. of Front. Biosci., Osaka Univ., 4Dept. of Biol. Sci., Osaka Pref.
Univ.)
1Pos208 Structural basis of photo-stability of invertebrate rhodopsins
Midori Murakami (Dept Physics, Nagoya Univ)
1Pos209 ロドプシンの構成的活性変異体 M257Y のメカニズムに関する分子動力学シミュレーション
Molecular dynamics simulation study on the mechanism of constitutively active mutant M257Y
of rhodopsin
Yuichiro Kanamori, Tadaomi Furuta, Minoru Sakurai (Tokyo Tech)
1Pos210 ラマン光学活性で観るハロロドプシン多量体形成による活性部位の構造変化
Raman optical activity observes a clear structural change of active site caused by trimer
formation of halorhodopsin
Shogo Ogawa1, Tomotsumi Fujisawa1, Takashi Kikukawa2,3, Masashi Unno1 (1Grad. Sch. Sci. Eng., Saga
Univ., 2Fac. Adv. Life Sci., Hokkaido Univ., 3GSS, GI-CoRE, Hokkaido Univ.)
1Pos211 ラマン光学活性による光駆動型内向きプロトンポンプの研究
Near-IR Raman optical activity spectroscopy of inward proton pump rhodopsin
Ryosuke Kuroiwa1, Tomotsumi Fujusawa2, Yuki Sudo3,4, Megumi Kamimura2, Saki Inoue3,
Masashi Unno2 (1Grad. Sch. Sci. Eng., Saga Univ., 2Fac. Sci. Eng., Saga Univ., 3Grad. Sch. of Med. Dent.
& Pharm. Sci., Okayama Univ., 4Fac. of Pharm. Sci., Okayama Univ.)
1Pos212 Actinotalea fementans 由来ヘリオロドプシンの物性解析
Molecular properties of Heliorhodopsin from Actinotalea fementans
Rei Abe-Yoshizumi, Ai Muto, Hideki Kandori (Nagoya Inst. Tech.)
1Pos213 (6-4)光回復酵素の光反応過程における時間分解分光研究
Time-resolved spectroscopic study on photoreaction of (6-4) photolyase
Daichi Yamada1, Takashi Nomura1, Yuna Nakajima2, Minoru Kubo1 (1Grad. Sch. Life Sci., 2Dept. Life
Sci., Univ. Hyogo, Japan)
1Pos214 集光クマリン色素を有する DNA 光回復酵素による高効率光駆動 DNA 修復
Enhanced light-driven DNA repair by DNA photolyase bearing light-harvesting coumarin
chromophore
Yuma Terai1, Ryuma Sato2, Risa Matsumura1, Shigenori Iwai1, Junpei Yamamoto1 (1Grad. Sch. Eng. Sci.,
Osaka Univ., 2RIKEN BDR)
– S116 –1Pos215

1Pos216

1Pos217

1Pos218

Impact of a water molecule on photoreduction of (6-4) photolyase
Yuhei Hosokawa1, Ryuma Sato2, Shigenori Iwai1, Junpei Yamamoto1 (1Grad. Sch. Eng. Sci., Univ. Osaka,
2Riken)Characterization of Antarctic inward proton pumping microbial rhodopsins (AntRs)
Andrew Harris1, Mizuho Tomita2, Luiz Schubert3, Michalis Lazaratos4, Ethan Watt1, Anh Hoang1,
Ana-Nicoleta Bondar4, Joachim Heberle3, Furutani Yuji2, Hideki Kandori2, Leonid Brown1 (1University ofGuelph, Physics, 2Nagoya Institute of Technology, Life Science and Applied Chemistry, 3Freie Universitat
Berlin, Experimental Physics, 4Freie Universitat Berlin, Theoretical Physics)
Inversion of Proton Transport Direction in Thermophilic Rhodopsin by Neutralizing theSecondary Counterion Asp229
Minori Kiyoshima1, Takashi Kikukawa2,3, Tomoyasu Aizawa2,3, Makoto Demura2,3, Yuki Sudo4,
Takashi Tsukamoto2,3 (1Grad. Sch. Life Sci. Hokkaido Univ., 2Fac. Adv. Life Sci. Hokkaido Univ., 3GSS,
GI-CoRE, 4Grad. Sch. Med. Dent. Pharm. Sci. Okayama Univ.)
シゾロドプシンの内向きプロトン輸送経路の特性
Characterization of the inward proton transport pathway in Schizorhodopsin
Masae Konno1,2, Keiichi Inoue1,3, Rohit Ghai4, Oded Beja5, Hideki Kandori1,2 (1Life Sci. Appl. Chem.,
Grad. Sch. Eng., NIT, 2OBTRC, NIT, 3ISSP, Univ. Tokyo, 4Aquatic Microbial Ecology, Biology Centre CAS,
Inst. Hydrobiol., 5Technion - Israel Inst. Tech.)
光生物学：光合成／Photobiology: Photosynthesis

1Pos219* 紅色光合成細菌由来光捕集反応中心 1 複合体のスペクトル多様性と安定性におけるカルシウムイ
オンの役割
A dual role for calcium in expanding the spectral diversity and stability of LH1-RC
photocomplexes of purple phototrophic bacteria
Michie Imanishi1, Mizuki Takenouchi2, Shinichi Takaichi3, Shiori Nakagawa4, Yoshitaka Saga4,
Shinji Takenaka1, Michael Madigan. T5, Jorg Overmann6, Zheng-Yu Wang-Otomo2, Yukihiro Kimura1(1Grad. Sch. Agricultural Sci., Kobe Univ., 2Fac. of Sci., Ibaraki Univ., 3Fac. of Life Sci., Tokyo Univ. ofAgriculture, 4Dep. of Chem., Kindai Univ., 5Dep. of Microbiol.., Southern Illinois Univ., 6Microbiol.,Braunschweig Univ. of Tech.)
1Pos220 超分子複合体構造を構成する光合成アンテナ組成の解明
Elucidation of supramolecular components in photosynthetic antenna
Tetsuko Nakaniwa1, Ryuichi Kano2, Naoko Norioka1, Soichiro Seki2, Ritsuko Fujii2,3, Genji Kurisu1(1IPR, Osaka Univ., 2Grad. Sch. Sci., Osaka City Univ., 3OCARINA, Osaka City Univ.)
1Pos221 Molecular mechanism of pH-dependent electron-flow regulation in photosystem II
Yuichiro Shimada1, Seiryu Nakajima1, Ryo Nagao1,2, Takumi Noguchi1 (1Grad. Sch. Sci., Nagoya Univ.,
2RIIS, Okayama Univ.)
1Pos222 緑藻の光捕集アンテナタンパク質 SCP の再構成
In-vitro reconstitution of light-harvesting complexes of a siphonous green alga, Codium fragile
Yuki Isaji1, Nami Yamano1,2, Masahiko Iha3, Tetsuko Nakaniwa4, Rei Toda5, Naoko Norioka4,
Genji Kurisu4,5, Ritsuko Fujii1,2 (1Grad. Sch. Sci., Osaka City Univ, 2OCARINA, Osaka City Univ.,
3SouthProduct Co. Ltd., 4IPR, Osaka Univ., 5Grad. Sch. Sci., Osaka Univ.)
1Pos223 LH2 タンパク質の B800 部位へ再構成したクロロフィル誘導体のスペクトル特性変化に対するテ
トラピロール環構造の影響
Structural effects of chlorophyll pigments on their spectral properties induced by reconstitution
into the B800 site in LH2 protein
Yoshitaka Saga, Madoka Yamashita, Kanji Miyagi (Faculty of Science and Engineering, Kindai
University)– S117 –1Pos224

1Pos225

1Pos226

1Pos227

1Pos228

1Pos229

1Pos230

1Pos2311Pos232*

1Pos233*

1Pos234*

1Pos235*

ガラス基板表面におけるチラコイド膜の再構成と光合成機能解析
Reconstitution and functional analysis of thylakoid membrane on a glass substrate
Takuro Yoneda1, Yasushi Tanimoto1, Daisuke Takagi2, Kenichi Morigaki1,3 (1Grad. Sch. Agr., Univ.
Kobe, 2Grad. Sch. Agr., Univ. Tohoku, 3Biosignal., Univ. Kobe)
光化学系複合体と酸化グラフェンを用いた水素発生
Hydrogen production using photosystem and graphene oxide
Shunsuke Sone1, Mriko Miyachi2, Shota Tanaka1, Hisataka Ohta1, Yoshinori Yamanoi2, Akihide Iwase1,
Akihiko Kudo1, Hiroshi Nishihara2, Tatsuya Tomo1 (1Tokyo University of science, 2The University ofTokyo)
緑藻ミル糸状体のカロテノイド蓄積における培養時光条件の影響
The effect of different light regimes for carotenoid accumulation of a macro green algae,
Codium fragile, in filamentous form
Soichiro Seki (Osaka city university , department of Chemistry, Research institute for natural science andtechnology)
Time-resolved infrared analysis of proton release pathways in photosynthetic water oxidation
using a D1-N298A mutant and NO3- substitution
Yasutada Okamoto1, Yuichiro Shimada1, Ryo Nagao1,2, Takumi Noguchi1 (1Grad. Sch. Sci., Nagoya
Univ., 2RIIS, Okayama Univ.)
QM/MM analysis of the protonation structure of the S0 state in the water-oxidizing Mn4CaO5cluster
Masao Yamamoto, Shin Nakamura, Takumi Noguchi (Grad. Sch. Sci., Nagoya Univ.)
Infrared microspectroscopic study on water oxidation in a single photosystem II microcrystal
Yuki Kato1, Satoshi Haniu1, Yoshiki Nakajima2, Fusamichi Akita2,3, Jian-Ren Shen2, Takumi Noguchi1(1Grad. Sch. Sci, Nagoya Univ., 2Res. Inst. Interdiscip. Sci., Okayama Univ., 3JST-PRESTO)
光化学系 II の表在性タンパク質による水分解 Mn4CaO5 クラスターの S2 構造異性体平衡の制御機構
Equilibrium of the S2-state isomers of the water-oxidizing Mn4CaO5 cluster in photosystem II
regulated by extrinsic proteins
Shota Taguchi1, Liangliang Shen2, Guangye Han2, Jian-Ren Shen3, Takumi Noguchi1, Hiroyuki Mino1(1Grad. Sch. Sci., Nagoya Univ., 2Key Lab. Photobiol., Inst. Botany, Chinese Acad. Sci., China, 3Res. Inst.
Interdiscip. Sci., Okayama Univ.)
Dynamics of photosystem II protein complexes as observed by high speed atomic force
microscopy
Takaya Tokano1, Yuki Kato1, Shogo Sugiyama2, Takumi Noguchi1, Takayuki Uchihashi1,3(1Grad.Sch.Sci.,Nagoya Univ., 2Grad.Sch.Phys.,Kanazawa Univ, 3EXCELLS)
酵素型ロドプシン（Rh―PDE）の非対称的 pH 効果
Asymmetric pH effect on the enzyme rhodopsin, Rh-PDE
Masahiro Sugiura1, Kazuho Yoshida1, Masahiro Hibi3, Satoshi Tsunoda1,2, Hideki Kandori1 (1Nagoya
Institute of Technology, 2JST PRESTO, 3Graduate School of Science, Nagoya University)
光活性型 bZIP モジュールであるフォトジッパーにおける Gln317 の役割
The role of Gln317 in a light-activatable bZIP module, Photozipper
Itsuki Kobayashi, Osamu Hisatomi (Grad. Sch. Sci., Univ. Osaka)
プロトンポンプ型ロドプシンによる緑藻クラミドモナスの 非光化学的消光(NPQ)の人為的光制御
Optical control of non-photochemical quenching (NPQ) in the alga Chlamydomonas reinhardtii
by light-driven proton pump rhodopsins
Yurie Nagase1, Keiichi Kojima1, Saki Inoue1, Hiroshi Kuroda2, Ryutaro Tokutsu3, Shinji Masuda4,
Jun Minagawa3, Yuichiro Takahashi2, Yuki Sudo1 (1Grad. Sch. of Med. Dent. & Pharm. Sci. Okayama
Univ., 2RIIS., Okayama Univ., 3Div. of Environ. Photobiol., NIBB, 4Cent. Biolog. Resources & Informatics,
Tokyo Inst. Technol.)
Theoretical study on molecular mechanics of natural anion channelrhodopsin GtACR1
Takafumi Shikakura, Cheng Cheng, Shigehiko Hayashi (Kyoto Univ.)– S118 –生命の起源・進化／Origin of life & Evolution
1Pos236

1Pos237

蝶のカモフラージュや擬態模様にみる多要素構造
Multi-component systems of camouflage and mimicry in butterfly wing patterns
Takao Suzuki (NARO)
巨大化大腸菌の再生過程可視化
Regeneration of Escherichia coli giant protoplasts
Kazuhito Tabata, Takao Sogo, Yoshiki Moriizumi, Hiroyuki Noji (Department of Applied Chemistry, The
University of Tokyo)
ゲノム生物学／Genome biology

1Pos238

1Pos239

大腸菌を用いた実験室内進化におけるタンパク質の配列進化速度の制約
Constraint of protein evolution speed in de novo experimental evolution of E. coli
Saburo Tsuru1, Atsushi Shibai2, Chikara Furusawa2 (1Sch. of Sci, The Univ. of Tokyo, 2RIKEN BDR)
(1SEA-5) Molecular Dynamics of Nucleosome Assembly
Giovanni Brandani, Shoji Takada, Cheng Tan (Dept Biophysics, Div Biology, Grad School Science, Kyoto
University)
生命情報科学／Bioinformatics

1Pos240

1Pos241

1Pos2421Pos243

1Pos244

全原子 Motion Tree による側鎖運動の記述とドメイン運動との連動
Full-atom Motion Tree detects side-chain motions and their coupling with domain motions
Ryotaro Koike, Motonori Ota (Grad. Sch. Info., Nagoya Univ.)
マルチカノニカル法を用いた蛋⽩質球状ドメイン外の相互作用の解析
Analysis of the protein-protein interaction between regions external to globular domains withmulti-canonical molecular method
Takuya Shimato1, Takuya Takahashi2, Kota Kasahara2, Junichi Higo3 (1Grad. Sch. Life Sci., Ritsumeikan
Univ., 2Coll. Life Sci., Ritsumeikan Univ., 3Grad. Sch. Sim. Studies, Univ. Hyogo)
並列タンパク質間相互作用予測システム MEGADOCK の高速化・仮想化
Acceleration and virtualization of parallel protein-protein interaction prediction system
MEGADOCK
Masahito Ohue1, Hiroki Watanabe1,2, Kento Aoyama1,2, Yutaka Akiyama1 (1Sch Computing, Tokyo Tech,
2RWBC-OIL, AIST)
蛋⽩質における Non-local 接触を持たない領域に関する統計解析
Segments without non-local contacts in protein structures
Kota Kasahara1, Shintaro Minami2, Yasunori Aizawa3, Ryohei Kondo4, Takuya Shimato4,
Takuya Takahashi1 (1Coll. Life. Sci., Ristumeikan Univ., 2EXCELLS, NINS, 3Sch. Life Sci., Tech.,TokyoTech, 4Grad. Sch. Life Sci., Ritsumeikan Univ.)
Direct coupling analysis of amino-acid sequences based on the Hopfield-Potts model
Kai Shimagaki, Martin Weigt (Sorbonne Universite, Paris-IV)
数理生物学／Mathematical biology

1Pos245

繊維状粒子凝集の CA タイプ解析
Attempts at CA-type formal analysis of fibrous assembly of particles
Takashi Konno (Biomath.Med.Univ.Fukui)– S119 –1Pos246

1Pos247

1Pos248

1Pos249

1Pos250

エピジェネティックな状態変化が細胞のがん化に及ぼす影響のランドスケープ理論による解析
Landscape analyses of epigenetic state change in cancerization
Yutaro Kameyama, Masaki Sasai (Dept. Appl. Phys., Grad. Sch. Eng., Univ. Nagoya)
筋分化過程で誘導される細胞競合は IGF シグナルを同期化する
Synchronization of IGF signal by cell competition during myogenesis
Fumihiko Hakuno, Masato Masuda, Ryosuke Okino, Shin-Ichiro Takahashi (Dep. App. Ani. Sci., Grad.
Sch. Agri. Life. Sci., The Univ. of Tokyo.)
モジホコリ変形体における輸送管ネットワークの分岐則
Direct observation of branching rules in transportation network of Physarum plasmodium
Masahiro Shibata, Atsuko Takamatsu (Dept. of Elec., Eng. & Biosci., Waseda Univ.)
シグナル伝達分子の細胞膜上クラスター形成機構の数理研究
Mathematical study on cluster formation of signaling proteins on the cell membrane
Hiroaki Takagi (Dep. Phys., Sch. Med., Nara Med. Univ.)
線虫の graded ニューロンはどのようにして確率的な 2 状態スイッチングダイナミクスを生成するか？
How do graded neurons generate stochastic binary switching dynamics in C. elegans?
Yuishi Iwasaki (Fac. Eng., Ibaraki Univ.)
非平衡・発生リズム／Nonequilibrium state & Biological rhythm

1Pos251* Effects of in vivo rhythm-damping mutations to KaiA on circadian rhythm in vitro
Masahiro Wakayama1, Risa Imada1, Yuki Nakamoto1, Rie Kumagai1, Keisuke Serizawa2,
Masahiro Ishiura3, Kousuke Maki1 (1Grad. Sch. Sci., Nagoya Univ., 2Sch. Sci., Nagoya Univ., 3Nagoya
Univ.)
1Pos252* Exploring a simply phosphorylation cycle by using phosphorylation site variants of clock protein
KaiC
Rie Kumagai1, Risa Imada1, Shun Terauchi1, Yuki Nakamoto1, Masahiro Ishiura2, Kosuke Maki1 (1Grad.
Sci, Nagoya Univ, 2Nagoya Univ)
1Pos253 (1SHA-4) 高圧力下で早くなるシアノバクテリアの概日周期(1SHA-4) Pressure accelerates the circadian clock of cyanobacteria
Ryo Kitahara1, Katsuaki Oyama2, Takahiro Kawamura2, Keita Mitsuhashi2, Soichiro Kitazawa1,
Kazuhiro Yasunaga1, Natsuno Sagara1, Megumi Fujimoto2, Kazuki Terauchi2 (1Pharm. Sci., Ritsumeikan
Univ., 2Life Sci., Ritsumeikan Univ.)
1Pos254 心筋細胞ネットワークにおける局所伝導ゆらぎの幾何学的理解
Geometrical understanding of the local fluctuation in propagation of excitation conduction in
cardiomyocyte network
Shota Aoki1, Kazufumi Sakamoto1, Yoshitsune Hondo2, Akihiro Hattori3, Masao Odaka3, Kenji Yasuda1,2,3(1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Sch.
Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda Univ.)
1Pos255 Observation of direction-dependent asymmetrical propagation velocities in excitation conduction
in a same cardiomyocyte networks on a chip
Kazufumi Sakamoto1, Shota Aoki1, Yoshitsune Hondo2, Masao Odaka3, Akihiro Hattori3,
Kenji Yasuda1,2,3 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure &Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda Univ.)– S120 –計測／Measurements
1Pos256

1Pos257

1Pos258

1Pos259

1Pos260

1Pos261

水素化アモルファスシリコンと紫外可視光変換で増強されたセンサのためのゲル電気化学素子と分子薄膜
Gel electrochemical element and molecular film for sensor enhanced by hydrogenatedamorphous silicon and ultra violet light conversion
Koki Shimanaka1, Shota Murakami1, Kairi Shimazaki1, Kishiro Seino1, Hikaru Hatakeyama1,
Shu Mugita1, Hiroshi Masumoto2, Takashi Goto3, Yutaka Tsujiuchi1 (1Mat Sci Akita Univ, 2FRIS Tohoku
Univ, 3IMR Tohoku Univ)
On-chip differential analysis of sequential phagocytosis on identical position of single
macrophages
Yuya Furumoto1, Toshiki Azuma1, Amane Yoshida1, Takahiro Kitahara2, Tomoyasu Sakaguchi2,
Masao Odaka3, Akihiro Hattori3, Kenji Yasuda1,2,3 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. &Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res.
Initiatives, Waseda Univ.)
水素化アモルファスシリコンに積層した脂質とバクテリオロドプシン複合膜の構造変化観察
Observation of structural change of lipid film and lipid and bacteriorhodopsin film laminated onhydrogenated amorphous silicon film
Hikaru Hatakeyama1, Hiroshi Masumoto2, Takashi Goto3, Yutaka Tsujiuchi1 (1MatSci AkitaUNIV, 2FRIS
TohokuUNIV, 3IMR TohokuUNIV)
高速走査レーザーマイクロダイセクションシステムの開発
Development of a high-speed scanning laser microdissection system
Masahito Hasegawa1,2, Yasushi Kudo2, Minako Hirano1, Hiroaki Yokota1 (1Grad.Sch.Creation Photon
Indust., 2Disc Tech)
光-電子相関顕微鏡法（CLEM）による同一試料観察に向けた相関・位置合わせ精度の評価
Evaluation of correlation and alignment accuracy toward the same sample observation by
CLEM
Yuki Gomibuchi1, Risa Ezoe2, Hiroko Takazaki1, Takuo Yasunaga1 (1Dept. of Phys. Info. Tech., Kyushu
Inst. Tech., 2Dept. of Biosci. Bioinfo., Kyushu Inst. Tech)
原子間力顕微鏡にひと工夫 －Volvox 1 個体の推進力を「直接」測る－
A trick to atomic force microscopy enabling direct measurement of forces generated byswimming Volvox spheroids
Noriyo Mitome1,2, Kosaku Horinaga2, Kazumo Wakabayashi2, Hikaru Emoto2, Airi Shintome2,
Kazutaka Fujita3, Noriko Ueki4, Ken-ichi Wakabayashi5, Katsuya Shimabukuro2 (1NIT, Chem. Biochem.,
Numazu Col., 2NIT, Chem. Bio. Eng., Ube Col., 3NIT, NIT, Mech., Ube Col., 4Sci. Res. Cent., Hosei Univ.,
5CLS, Tokyo Tech)
バイオイメージング／Bioimaging

1Pos262

Intron seqFISH enables transcriptome-wide visualization of genome organization and nascenttranscription in single cells
Yodai Takei1, Sheel Shah2, Wen Zhou1, Eric Lubeck3, Jina Yun1, Chee-Huat Linus Eng1,
Noushin Koulena1, Christopher Cronin1, Christoph Karp1, Eric Liaw2, Mina Amin4, Long Cai1 (1California
Institute of Technology, 2University of California, Los Angeles, 3Stanford University, 4University ofCalifornia, Riverside)– S121 –1Pos263* (3SEA-2) ラマンイメージングを用いた細胞内の水の可視化とラベルフリー細胞内温度測定への応用(3SEA-2) Raman imaging of water in a cell and its application to label-free evaluation of
intracellular temperature
Toshiki Sugimura, Shinji Kajimoto, Takakazu Nakabayashi (Grad. Sch. Pham. Sci., Tohoku. Univ)
1Pos264* Elastin 様ポリペプチドに基づく分子温度センサー
Molecular Thermometer Based on Elastin-Like Polypeptide
Cong Vu, Tetsuichi Wazawa, Takeharu Nagai (ISIR, Osaka Univ.)
1Pos265* 新規小分子プローブによるアクチン繊維の可視化と光操作
Visualization and manipulation of actin cytoskeleton by using novel small molecular probes
Takeru Takagi1, Tasuku Ueno1, Yusuke Nomura1, Daisuke Asanuma2, Yasuteru Urano1,2,3 (1Grad. Sch.
Pharm. Sci., The Univ. Tokyo, 2Grad. Sch. Med., The Univ. Tokyo, 3AMED, CREST)
1Pos266 (1SCP-6) グルタミン酸受容体を介した植物の長距離 Ca2+シグナル(1SCP-6) Long-distance Ca2+ transmission via glutamate receptor channels in plants
Masatsugu Toyota1,2 (1Dept Biochem and Mol Biol, Saitama Univ, 2University of Wisconsin-Madison)
1Pos267 (1SDP-4) Visualization and quantification of biological samples by high-speed atomic force
microscope
Hiroki Watanabe1,2, Koichi Kato1,2,3, Takayuki Uchihashi1,4 (1NINS, ExCELLS, 2NINS, IMS, 3Grad. Sch.
Pharm. Sci., Nagoya City Univ., 4Dept. Phys., Nagoya Univ.)
1Pos268 (1SGA-8) 細胞内動態をサブセルレベルで制御する温和な NanoHeating 技術(1SGA-8) A Thermodynamic Tool for Mechanobiology Research: Mild Nanoheating Technology
to Alter Subcellular Dynamics
Satoshi Arai1, Nandus Ferdi2 (1Res. Inst. Sci. Eng., Waseda Univ., 2WABIOS)
1Pos269 クライオ電子顕微鏡により明らかになったノロウイルスの動的構造変化
Dynamic Structural Change of Norovirus Revealed by Cryo-electron Microscopy
Chihong Song1, Reiko Todaka2, Masaru Yokoyama3, Naoyuki Miyazaki4,5, Kenji Iwasaki4,5,Kazuhiko Katayama2, Kazuyoshi Murata1 (1NIPS, 2Kitasato Univ., 3NIID, 4IPR, Osaka Univ., 5Univ.
Tsukuba)
1Pos270 化学発光ビリルビンセンサーの開発
Development of bioluminescent unconjugated bilirubin indicator
Yukino Ito1, Yoshiyuki Arai2, Mitsuru Hattori2, Takeharu Nagai2 (1Graduate School of Frontier
Biosciences, Osaka University, 2The Institute of Scientific and Industrial Research, Osaka University)
1Pos271 高速原子間力顕微鏡 1 分子計測データを用いた粒子フィルタ法によるリンカー DNA 付きヌクレオ
ソームの動的構造解析
Dynamic structure analysis of nucleosome with linker DNAs by particle filter method using
single molecule measurement data by HS-AFM
Sotaro Fuchigami1,2, Toru Niina1, Shoji Takada1,2 (1Grad. Sch. of Science, Kyoto Univ., 2CREST, JST)
1Pos272 化学発光トロンビンセンサーの開発
Development of chemiluminescent thrombin sensor toward whole body imaging of living mice
Nae Sugiura1, Mitsuru Hattori2, Tomoki Matsuda2, Takeharu Nagai2 (1Graduate School of Frontier
Biosciences, Osaka univ., 2Institute of Scientific and Industrial Research, Osaka univ.)
1Pos273 ESPT 型バイオセンサーの設計
Design of fluorescent biosensors based on Excited State Proton Transfer (ESPT) in thechromophore of a fluorescent protein
Kazunori Sugiura1,2, Toru Hisabori2, Shoko Mihara2, Takeharu Nagai1 (1ISIR, Univ. Osaka, 2CLS, Tokyo
Tech)
1Pos274 4 次元透過型電子顕微鏡：理論とシミュレーション
4-Dimensional Transmission Electron Microscopy: Theory and Simulation
Kuniaki Nagayama (N-EM Labos LLC)

– S122 –1Pos275

1Pos2761Pos277

1Pos278

1Pos279

1Pos280

環境の温度変化に対する細胞応答の分子機構
The molecular mechanism of cell response to environmental temperature change
Hiroki Shibata1, Kohki Okabe1,2, Takashi Funatsu1 (1Grad. Sch. of Pharm. Sci., The Univ of Tokyo,
2PRESTO, JST)
相平衡状態にある核小体内領域における核小体構成タンパク質の 1 分子動態と超解像分子局在解析
Single-molecule dynamics and localization of nucleolar proteins in phase-separated
compartments of nucleolus
Supanut Sirisukhodom1, Daiki Matsumoto1, Yuma Ito1, Noriko Saitoh2, Kumiko Sakata-Sogawa3,
Makio Tokunaga1 (1Sch. Life Sci. Tech., Tokyo Tech, 2Dept. of Cancer Biol., The Cancer Inst. JFCR.,
3Grad. Sch. Agr. Sci., Tohoku Univ.)
Development of designable RNA-binding proteins for visualization and manipulation of authentic
RNAs in living cells
Akira Takai1, Yasushi Okada1,2 (1BDR, RIKEN, 2Univ. of Tokyo, Grad. Sch. of Sci., Dept. of Phys.)
相分離に関わるヘテロクロマチンタンパク質 HP1α の 1 分子超解像イメージングによる分子局在と動態
Dynamics and localization of Heterochromatin protein 1α involved in phase separation using
single-molecule and super-resolution imaging
Takahiro Maeda1, Yuma Ito1, Shin-Ya Isobe2, Chikashi Obuse2, Makio Tokunaga1 (1Sch. Life Sci. Tech.,Tokyo Tech, 2Biosci. Grad Sch Sci., Osaka Univ)
Imaging transcriptional dynamics of the endogenous gene with a bright fluorogenic RNA
Tetsuro Ariyoshi1, Yasushi Okada1,2 (1RIKEN BDR, Cell Polarity Regulation, 2Dept. Phys., Grad. Sch.
Sci., UTokyo)
ネクロプトーシスに伴う DAMPs 放出の LCI-S による可視化
Live Cell Imaging for Secretion Activity (LCI-S) of DAMPs Release Accompanying with
Necroptosis
Yoshitaka Shirasaki1,2, Mai Yamagishi1, Sotaro Uemura1 (1Dept. of Biological Sciences, Grad School of
Science, The Univ. of Tokyo, 2JST PRESTO)
バイオエンジニアリング／Bioengineering

1Pos281* 単一分子伝導計測に基づく表面上の DNA ハイブリダイゼーションの反応速度論解析
Kinetic investigation of DNA hybridization on surface using single-molecule conductancemeasurement
Takanori Harashima, Yuki Jono, Tomoaki Nishino (Sch. Sci., TokyoTech.)
1Pos282* 制御・情報技術の統合による集団内細胞行動特徴の定量解析
Quantitative analysis of collective cell migration by integration of controlled in vitro experimentand information processing
Asuka Yamaguchi1, Masakazu Akiyama2, Ikuhiko Nakase3, Masaya Hagiwara4 (1Sch. Sci., Osaka Pref.
Univ., 2MIMS, Meiji Univ., 3Grad. Sch. Sci., Osaka Pref. Univ., 4RIKEN, CPR)
1Pos283* 分散培養心筋細胞と心臓組織片の電気生理学的信号の同期
Synchronization of electrophysiological signal between dispersed cardiomyocytes and cardiac
tissue piece
Toru Nakamura, Chiho Nihei, Tomoyuki Kaneko (Laboratory for Reconstructive Cell biology,
Department of Frontier Bioscience, Hosei University, Grad. School of Science and Engineering)
1Pos284 DNA ナノデバイスを制御する DNA 生成回路の検証
Characterization of DNA Generation Circuits for Controlling DNA Nanodevices
Ken Komiya, Teruya Enomoto, Masayuki Yamamura (Sch. Comp., Tokyo Tech.)
1Pos285 Photo-control of Ras nucleotide exchange reaction using the inhibitor peptides modified withspiropyran derivative
Kenichi Taii1, Nobuyuki Nishibe1, Kei Sadakane2, Shinsaku Maruta1,2 (1Dept. of Bioinfo., Grad. Sch. ofEng., Soka Univ., 2Dept. of Sus. Inno., Fac. of Sci. and Eng., Soka Univ.)– S123 –結晶成長・結晶化技術／Crystal growth & Crystallization technique1Pos286

アポフェリチンを使ったマグネタイト単結晶ナノ粒子の作製
Synthesis of single crystal magnetite nanoparticles in apoferritin cavity
Tomoko Kanamaru, Daisuke Katayama, Naoki Takasihima, Takeshi Narusima, Hideyuki Yoshimura (Dpt.
Phys., Meiji University)
その他／Miscellaneous topics

1Pos287

1Pos288

1Pos289

1Pos290(1SCA-5) 光からエネルギーを合成しタンパク質合成をする人工光合成細胞の構築(1SCA-5) Artificial photosynthetic cell producing energy for protein synthesis
Samuel Berhanu2, Takuya Ueda3, Yutetsu Kuruma1 (1JAMSTEC, 2ELSI, Titech, 3Grad. Sch. of Front. Sci.,
Univ. of Tokyo)
人工細胞-生細胞ハイブリッドバイオシステムの創成
Synthesis of artificial/living cell hybrid biosystems
Masamune Morita, Kaoru Katoh, Naohiro Noda (Biomed. Res. Inst. (BMRI), AIST)
Mycolicibacterium smegmatis のストラクトーム解析
Structome analysis of Mycolicibacterium smegmatis
Hiroyuki Yamada1, Masashi Yamaguchi2 (1Res. Inst. Tuberculosis., JATA., 2Mycol. Res. Cent., Chiba)
Identification of lipid interactions in the transmembrane regions of human Na+, K+-ATPase
Dhani Ram Mahato, Magnus Andersson (Dept. Che., Ume Univ.)
2 日目（9 月 25 日（水））／Day 2（Sep. 25 Wed.）
4F 天瑞・ホワイエ／4F TENZUI・Foyer
蛋⽩質：構造／Protein: Structure

2Pos001* Mycoplasma mobile のモーターを構成するタンパク質 MMOB1620 の構造解析
Structural analysis of MMOB1620 which composes Mycoplasma mobile’s motor
Hiroki Sato1, Aya Kodama2, Hisashi Kudo3, Koji Ooka4, Syunji Suetaka3, Yuuki Hayashi3,
Munehito Arai3,4, Makoto Miyata1,2 (1Graduate School of Science, Osaka City University, 2Faculty of
Science, Osaka City University, 3Dept. Life Sci., Univ. Tokyo, 4Dept. Phys., Univ. Tokyo)
2Pos002* 異なる長さの C 末端領域を持つテロメア繰り返し配列結合タンパク質 AtTRP1 の DNA 結合領域に対する構造研究
Structural studies for DNA binding domain of telomere repeat binding protein, AtTRP-1 withdifferent size of C-terminal region
Shunta Kojima1, Hayato Morita2 (1Grad. Sch. Sci., Josai.Univ, 2Fac.Sci., Josai.Univ)
2Pos003* PaCS-MD によるタンパク質−タンパク質複合体の解離シミュレーション
Protein-protein complexes dissociation simulated by Parallel Cascade Selection Molecular
Dynamics
Yoshiki Miyazawa1, Duy Phuoc Tran2, Kazuhiro Takemura2, Akio Kitao2 (1Grad. Sch. LST.,Tokyo Tech,
2Sch. LST.,Tokyo Tech)
2Pos004 Deep-Autoencoder に基づいたホモロジーモデリングソフトウェアの開発
Development of Deep-Autoencoder based Homology Modeling software
Masaya Furue, Mitsutaka Nemoto, Lisa Matsukura, Naoyuki Miyashita (BOST KINDAI Univ.)– S124 –2Pos005

2Pos006

2Pos007

2Pos008

2Pos009

2Pos010

2Pos011

2Pos012

2Pos013

2Pos014

2Pos015

Caged-GTP を用いたがん遺伝子産物 Ras の SACLA, SPring-8, NMR による GTP 加水分解過程の構造変化の解明
Structural changes on GTP hydrolysis of oncogene product Ras revealed by SACLA, SPring-8
and NMR using photo-controllable caged-GTP
Yoshiteru Makino1, Takashi Kawamura2, Shigeyuki Matsumoto1, Eriko Nango3, So Iwata3,
Takashi Kumasaka2, Fumi Shima4 (1Grad. Sch. Med., Kobe. Univ., 2Protein Cryst. Anal. Div., JASRI.,
3Grad. Sch. Med., Kyoto Univ., 4Grad. Sch. Sci. Tec. Innov., Kobe Univ.)
アブラナ科植物の自家不和合性を制御するタンパク質 SRK/SP11 複合体の Rosetta と accelerated
MD を用いた構造モデリング
Computational modeling of SRK/SP11 protein complexes using Rosetta and accelerated MD
simulations
Yoshitaka Moriwaki1, Tohru Terada1,2, Koji Murase1, Kentaro Shimizu1 (1Grad. Sch. Agr. Life Sci., Univ.
Tokyo, 2III, Univ. Tokyo)
粗視化シミュレーションによる CDK4 の構造変化に関する研究
Conformational transition of CDK4 by using coarse-grained simulations
Kazutomo Kawaguchi, Hidemi Nagao (Inst. Sci. Eng., Kanazawa Univ.)
Single particle analysis of silkworm lipid transfer protein complex, lipophorin
Shunsuke Kita1, Kazuhiro Mio2, Mika Hirose3, Kenji Iwasaki4, Naruhiko Adachi5, Toshio Moriya5,
Masato Kawasaki5, Katsumi Maenaka1 (1Fac. of Pharm. Sci., Hokkaido Univ., 2Operand OIL, AIST, 3IPR,
Osaka Univ., 4TARA, Univ. of Tsukuba, 5SBRC, KEK)
HIV-2 糖タンパク質の構造機能解析
Structure and functional analysis of human immunodeficiency virus type-2 (HIV-2) envelope
glycoprotein
Yuki Anraku1, Shunsuke Kita2, Hideo Hukuhara2, Simon Davis3, Atsushi Hurukawa2, Thushan de Silva3,
James Robinson4, Yuguang Zhao3, Yvonne Jones3, David Stuart3, Juha Huiskonen3, Sarah Rowland-Jones3,
Katsumi Maenaka2 (1Grad. Sch. Life Sci., Univ. Hokkaido, 2Faculty of Pharm Sci., Univ. Hokkaido, 3Univ.
Oxford, 4Univ. Tulane)
分子動力学シミュレーションを用いた α シヌクレインアミロイドの構造解析
Structural analysis of α-synuclein amyloids using molecular dynamics simulation
Hiroki Otaki, Yuzuru Taguchi, Noriyuki Nishida (Grad. Sch. Biomedical Sci., Nagasaki Univ.)
翻訳後修飾によってシトルリン化したヒト S100A3 蛋⽩質の擬似体の探索
Exploring the posttranslational modification of human S100A3 protein using citrullination mimics
Kenji Ite1,2, Kenji Kizawa3, Kenichi Kitanishi4, Masaki Unno1,2 (1Graduate School of Science andEngineering, Ibaraki University, 2Frontier Research Center for Applied Atomic Sciences, Ibaraki
University, 3Kao Corporation, 4Department of Chemistry, Faculty of Science, Tokyo University of Science)
機械学習を用いたタンパク質主鎖構造における 2 面角の再分類
Reclassification of dihedral angles in protein backbone structures using machine learning
Hiroto Murata, George Chikenji (Dept. Appl. Phys., Nagoya Univ.)
糖化が LDL の物性に与える影響について
Effect of glycation on the physical properties of low density-lipoprotein
Seiji Takeda1, Toshihiro Sakurai1, Shu-Ping Hui1, Hitoshi Chiba2 (1Faculty of Health Sciences, Hokkaido
Univ., 2Faculty of Health Science, Sapporo University of Health Sciences)
酵母プリオン Sup35 の液-液相分離と線維化に対する共溶質の影響
Effects of co-solutes on liquid-liquid phase separation and fibrillization of yeast prion Sup35
Suguru Nishinami1, Yumiko Ohhashi2, Kentaro Shiraki1 (1Pure and Appl. Sci., Univ. Tsukuba, 2Grad. Sch.
Sci., Univ. Kobe)
局所クラスター間構造コンプライアンスに基づくタンパク質の形状に内在する変形伝播特性の解析
Analysis of the Deformation Transmission Properties in Protein Shapes based on the Structural
Compliance between Localized Clusters
Keisuke Arikawa (Fcl. Eng., Kanagawa Inst. of Tech.)– S125 –2Pos016

2Pos017

2Pos018

2Pos019

2Pos020

2Pos021

2Pos022

フェレドキシン構造とそのリバース構造の、PDB における発生頻度が異なるのはなぜか？
Why occurring frequencies of ferredoxin and its reverse fold in PDB are largely different?
Megumi Nakajima, George Chikenji (Nagoya University Graduate School of Engineering Department ofApplied Physics Sasai Laboratory)
Structural Characterization of β2 Microglobulin Core Fragments in Amyloid Fibrils using Circular
Dichroism Theory and Molecular Dynamics
Koichi Matsuo1,3, Hirotsugu Hiramatsu2, Robert W. Woody3 (1Hiroshima Synchrotron Radiation Center,
Hiroshima University, 2Department of Applied Chemistry, National Chiao Tung University, 3Department ofBiochemistry and Molecular Biology, Colorado State University)
B 型肝炎ウイルス(HBV)への逆転写阻害薬剤分子のカプシド内部の自由エネルギー計算
Calculation of free energy of transfer of a reverse transcription inhibitor to the inside of Hepatitis
B Virus (HBV) capsid
Ryo Urano1, Kazushi Fujimoto1, Yoshimichi Andoh2, Noriyuki Yoshii2, Wataru Shinoda1,
Susumu Okazaki1 (1Grad. Sch. Eng., Nagoya Univ., 2Center Comput. Sci. Grad. Sch. Sci., Nagoya Univ.)
アンチパラレル β シート中のジスルフィド結合が分泌タンパク質ホールディングに及ぼす影響
The effect of disulfide bonds in anti-parallel β-sheets on secreted protein folding
Hiromi Suzuki (School of Agri., Meiji Univ.)
エンドセリン B 受容体の分子動力学シミュレーション
Molecular dynamics simulations of human endothelin B receptor
Koichi Abe1, Yoshitaka Moriwaki1, Kentaro Shimizu1,2, Tohru Terada2 (1Grad. Sch. Agr. Life Sci., Univ.
Tokyo, 2III, Univ. Tokyo)
クライオ電子顕微鏡単粒子解析法を用いた KcsA の構造解析
Structural Analysis of KcsA by Cryo-EM Single Particle Analysis
Hiroko Takazaki1, Hirofumi Shimizu2, Takuo Yasunaga1 (1Grad. Sch. Comp. Sci. Syst. Eng., KIT, 2Fac.
Med. Sci., Univ. Fukui)
マスク付きセグメンテーション・フィット法による複数サブユニットの電顕マップへの局所重ね合わせ
Masked segmentation fitting of multiple atomic subunits into a local 3D EM density map
Takeshi Kawabata, Haruki Nakamura, Genji Kurisu (Institute for Protein Research, Osaka University)
蛋⽩質：構造機能相関／Protein: Structure & Function

2Pos023* 糸状仮足の構造変化とアクチンフィラメントの分布の相関
Correlation between structural changes of filopodia and distribution of actin filaments
Miho Nakafukasako, Tomoya Higo, Yusuke V. Morimoto, Takuo Yasunaga (Grad. Sch. Comp. Sci. Syst.
Eng., KIT.)
2Pos024* Does the secondary site of neuraminidase play any significant role in drug resistance of
influenza?
Mohini Yadav1, Manabu Igarashi2, Norifumi Yamamoto1 (1Dept. of Engg., Chiba Inst. Tech., 2ResearchCenter for Zoonosis Control, Hokkaido Univ.)
2Pos025* 多次元 NMR 分光法を用いたヤエヤマサソリ由来殺虫性ペプチド毒素 LaIT2 の機能領域の溶液構造解析
Structural studies for the functional domains of insecticidal peptide toxin, LaIT2, withheteronuclear multidimensional NMR spectroscopy
Chiharu Tatsushiro1, Maiki Tamura2, Hironori Juichi3, Masahiro Miyashita3, Hisashi Miyagawa3,
Shinya Ohki2, Hayato Morita1,4 (1Fac Sci., Josai Univ, 2Grad. Sch. Mat Sci., JIAST, 3Grad. Sch. Agr., Kyoto
Univ, 4Grad. Sch. Sci., Josai Univ)
2Pos026* 分子動力学計算で探る p53 の C 末端部位の DNA 結合機構
DNA recognition mechanisms of the p53 C-terminal domain Investigated by MD simulation
Yuta Taira1, Duy Tran1, Jacob Swadling2, Akio Kitao1 (1Tokyo Tech, 2Univ.Tokyo)– S126 –2Pos027* 天然変性タンパク質 Tau の溶液中における過渡的な凝集原繊維構造形成
Intrinsically disordered protein Tau tends to transiently form a part of the protofilament core
structure in the soluble state
Ryosuke Kawasaki1, Shin-ichi Tate2 (1Dept. MLS, Grad. Sch. Sci., Hiroshima Univ., 2Prog. MLS, Grad.
Sch. Integr. Sci. for Life, Hiroshima Univ.)
2Pos028 Single-molecule FRET experiments for investigation of DNA single-strand damage recognition
mechanism by PARP-1
Anna Sefer1, Eleni Kallis1, Tobias Eilert1, Mara Guariento1, Nadine Jakobi1, David Neuhaus2,
Sebastian Eustermann3, Jens Michaelis1 (1Ulm University, Institute of Biophysics, Albert-Einstein Allee 11,89081 Ulm, Germany, 2MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, UK, 3Ludwig-Maximilians-University Munich, Gene Center and Department of Biochemistry,
Feodor-Lynen-Strasse 25, 81377 Munich, Germany)
2Pos029 (2SGP-3) Determination of protonated states for native and mutant structures of HIV-1 proteasewith indinavir by free energy calculations
Masahiko Taguchi, Ryo Oyama, Masahiro Kaneso, Shigehiko Hayashi (Kyoto University)
2Pos030 Crucial role of conformational excitation in enzyme catalysis of Pin1
Toshifumi Mori1,2, Shinji Saito1,2 (1IMS, 2SOKENDAI)
2Pos031 Weighted ensemble simulations of the cis-trans isomerization in Pin1 enzyme using the QM/MM
methodNorifumi Yamamoto1, Kei Moritsugu2, Yasushige Yonezawa3, Shin-ichi Tate4, Hiroshi Fujisaki5 (1Chiba
Tech, 2Yokohama City Univ, 3Kindai Univ, 4Hiroshima Univ, 5Nippon Med Sch)
2Pos032 Simulation Study on Atomistic and Physicochemical Properties of Amyloid beta 42
Ikuo Kurisaki, Shigenori Tanaka (System Info., Grad. Schl., Kobe Univ.)
2Pos033 敵対的生成ネットワーク（GAN）を用いた新規主鎖構造のタンパク質デザイン
Protein design with novel main-chain structure using Generative Adversarial Networks
Takaaki Sato1, Yoshitaka Moriwaki1, Tohru Terada2, Kentaro Shimizu1,2 (1Grad. Sch. Agr. Life Sci., Univ.
Tokyo, 2III, Univ. Tokyo)
2Pos034 テルペン環化酵素における基質と反応の選択性に関する計算科学的研究
Computational investigation of the substrate and reaction selectivity of terpene cyclases
Masanobu Arita1, Keiichi Murai1, Yoshitaka Moriwaki1, Tohru Terada2, Tomohisa Kuzuyama1,
Kentaro Shimizu1,2 (1Grad. Sch. Agr. Life Sci., Univ. Tokyo, 2III, Univ. Tokyo)
2Pos035 Pin1 由来のタンパク質分解酵素のミクロ化
Micronization of a protease derived from Pin1
Teikichi Ikura, Nobutoshi Ito (Med. Res. Inst., Tokyo Med. Dent. Univ.)
2Pos036 緑色硫黄細菌 ferredoxin-NADP+酸化還元酵素と基質間の酸化還元反応の特異性
Unique kinetic behavior in the redox reaction catalyzed by ferredoxin-NADP+ oxidoreductase
from green sulfur bacteria
Daisuke Seo (Grd. Sch. Nat. Sci. Tec., Kanazawa Univ.)
2Pos037 タンパク質キナーゼへの ATP 競合阻害剤結合の自由エネルギー解析
Free energy analysis of ATP competitive inhibitor-protein kinase bindings
Suyong Re, Hiraku Oshima, Yuji Sugita (RIKEN Center for Biosystems Dynamics Research)
2Pos038 フォトンファクトリーにおける生体高分子溶液試料の小角 X 線散乱に関する発展
Progress of Biological Small-Angle X-ray Scattering at the Photon Factory
Kento Yonezawa, Masatsuyo Takahashi, Keiko Yatabe, Yasuko Nagatani, Nobutaka Shimizu (KEK,
IMSS, PF)– S127 –2Pos039

2Pos040

2Pos041

2Pos0422Pos043

2Pos044

2Pos045

2Pos046

抗体修飾ナノニードルを用いた生細胞における中間径フィラメントの可動性解析
Mobility analysis of intermediate filament in a living cell using antibody-functionalized
nanoneedle and AFM
Ayana Yamagishi1,2,5, Moe Susaki1,2, Mei Mizusawa1,2, Akira Nagasaki1, Saku Kijima3,
Q.P. Taro Uyeda1,4, Chikashi Nakamura1,2,5 (1Biomed. Res. Inst., AIST, 2Dept. Biotechnol. & Life Sci.,
Grad. Sch. Eng., TUAT, 3Bioproc. Res. Inst., AIST, 4Dept. Phys., Sch. Adv. Sci. Eng., Waseda Univ.,
5PhotoBio-OIL, AIST-Osaka Univ.)
Investigation on the relationship between cytotoxicity and amorphous oligomers
Punitha Velmurugan, Jannatul Aklima, Yoshihiro Ohta, Yutaka Kuroda (Tokyo university of Agriculture
and Technology)
In vitro ATPase-based screening of circadian clock mutants of KaiC in cyanobacterial circadianclock system
Dongyan Ouyang1, Atsushi Mukaiyama1,2, Yoshihiko Furuike1,2, Kumiko Miwa3, Takao Kondo3,
Shuji Akiyama1,2 (1Inst. Mol. Sci., 2The Grad. Univ. for Adv. Studies, 3Grad. Sch. of Sci., Nagoya Univ)
構造蛋⽩質である HIV-1p17 と p24 の動的と静的構造の解析
Dynamic and rigid structures of HIV-1 p17 and p24 proteins
Chiaki Nishimura (Fac. Pharm. Sci., Teikyo Heisei Univ.)
アミロイドベータタンパク質を分解する人工ペプチドの設計
Designing artificial peptides that hydrolyze amyloid beta protein
Yoshihiro Iida, Atsuo Tamura (Kobe Univ, Grad Sch Sci)
4 つのイントロン位置は、アスパラギン酸アミノ転移酵素立体構造上で平面を形成する。
Four intron positions form a plane in the tertiary structure of aspartate aminotransferase
Michiko Nosaka (N.I.T., Sasebo College)
抗微生物ペプチド Cryptdin-4 の多量体の脂質分子存在下における分子シミュレーションによる観察
Antimicrobial peptide Cryptdin-4 oligomers interacting with lipids observed by molecular
dynamics simulations
Takao Yoda (Nagahama Institute of Bio-Science and Technology)
ヘム ABC インポーター BhuUV-T の構造変化の自由エネルギー解析
Free energy analysis for the conformational changes of a heme ABC importer BhuUV-T
Koichi Tamura1, Yuji Sugita1,2,3 (1RIKEN R-CCS, 2RIKEN TMS, 3RIKEN BDR)
蛋⽩質：物性・構造／Protein: Property & Structure

2Pos047* トレハロースによるミオグロビンの構造安定化および酸性条件下でのアミロイド形成からの回復
作用
Stabilization of the Myoglobin Structure and Restoration from the Amyloid Formation under
Acidic Conditions by Trehalose
Satoshi Ajito1, Mitsuhiro Hirai1, Nobutaka Shimizu2, Noriyuki Igarashi2 (1Grad. Sch. Sci. Tec., Gunma
Univ., 2KEK)
2Pos048* 異なる緩衝剤中での抗体の安定性と構造変化の関係
Relation between stability and structure of an antibody in different buffers
Hiroaki Oyama1, Kanta Enomoto1, Tetsuo Torisu1, Susumu Uchiyama1,2 (1Grad. Sch. Eng, Osaka Univ,
2ExCELLS)
2Pos049* ショウジョウバエ Argonaute2 の N 末端領域はアミロイド繊維を形成する
N-terminal region of Drosophila Argonaute2 can form amyloid fibrils
Haruka Narita, Makoto F. Kuwabara, Tomotaka Komori, Ryo Murakami, Tomohiro Shima,
Mikiko C. Siomi, Soutaro Uemura (Department of Biological Sciences, Graduate School of Science, The
University of Tokyo)– S128 –2Pos050* Dynamics of the helix-coil transition of alanine-based polypeptides detected by nanosecond
region fluorescence correlation spectroscopy
Supawich Kamonprasertsuk1,2, Hiroyuki Oikawa1,2, Satoshi Takahashi1,2 (1IMRAM.Tohoku Univ.,
2Grad.Sch.Sci.,Tohoku Univ.)
2Pos051 MD simulation along with MSM analysis reconstructs LPA6 binding pathway

2Pos052

2Pos053
2Pos054

2Pos055

2Pos056

Rieko Hirota1, Ryuichiro Ishitani1, Mizuki Takemoto1,2, Osamu Nureki1 (1Dept. of Biosci., Grad Sch. ofSci., Univ. of Tokyo, 2Present address: Preferred Networks, Inc.)
加熱による中性 pH での β2 ミクログロブリンのアミロイド線維形成
Heating-induced amyloid formation of β2-microglobulin at neutral pH
Masahiro Noji1, Kenji Sasahara1, Keiichi Yamaguchi1, Masatomo So1, Kazumasa Sakurai2,
Jozsef Kardos3, Hironobu Naiki4, Yuji Goto1 (1IPR, Osaka Univ., 2IAT, Kindai Univ., 3Dept. Biochem.,
ELTE, 4Med. Sci., Univ. Fukui)
Functional Sensitivity and Mutational Robustness of Proteins
Qianyuan Tang, Tetsuhiro Hatakeyama, Kunihiko Kaneko (Grad. Sch. Art. & Sci., Univ. Tokyo)
多次元仮想座標とカップルした分子動力学法を用いた mSin3 複合体の立体構造探索
Conformational sampling of an mSin3 complex using multidimensional virtual-system coupledcanonical MD
Tomonori Hayami1,2, Yoshifumi Fukunishi3, Yoshifumi Nishimura4, Junichi Higo5 (1IPR, Osaka Univ.,
2Grad. Sch. Fron. Biosci., Osaka Univ., 3molprof, AIST, 4Grad. Sch. Med. Life Sci., Yokohama City Univ.,
5Grad. Sch. Sim. Studies., Univ. Hyogo)
アデニル酸キナーゼの構造転移の改良カメレオンモデルによる研究
Conformational transition of adenylate kinase studied with the improved chameleon model
Ryota Mori, Masaki Sasai, Tomoki P. Terada (Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.)
Spectroscopic analysis of protein crowded environments using the charge-transfer fluorescenceprobe ANS
Chikashi Ota1, Kazufumi Takano2 (1Ritsumeikan Univ., 2Kyoto Pref. Univ.)
蛋⽩質：機能／Protein: Function

2Pos057

2Pos058

2Pos059
2Pos060

2Pos061(2SHA-6) ダイナミン GTP アーゼはアクチン線維の束化と分散を機械的に制御する(2SHA-6) Dynamin GTPase mechanically regulates bundling and unbundling of actin filaments
Kohji Takei1, La The Mon1, Tadashi Abe1, Tetsuya Takeda1, Ikuko Fujiwara2, Akihiro Narita3 (1Grad.Sch.
Med.Dent. Pharm.Sci., Okayama Univ., 2Dept. Biol.Facul.Sci., Osaka City Univ., 3Struct. Biol. Res. Ctr andDivi. Biol. Sci., Grad. Sch. Sci., Nagoya Univ.)
FRET リアルタイム活性測定系を用いた大腸菌 S2P ファミリー膜内切断プロテアーゼ RseP のkinetics 解析
Kinetic analysis of the proteolytic reaction catalyzed by S2P family intramembrane protease
RseP using a FRET-based real-time assay system
Yohei Hizukuri, Yoshinori Akiyama (Inst. Front. Life Med. Sci., Kyoto Univ.)
Recognition mechanism of proteins which bind to versatile amino acid sequences
Katsumi Omagari (Dept. of Virology, Medical School, Nagoya City University)
呼吸鎖超複合体形成タンパク質によって制御される Cyt c のパートナータンパク質認識機構
The mechanism of cytochrome c-redox partner proteins recognition regulated by the respiratory
supercomplex factor protein
Wataru Sato1, Koichiro Ishimori2, Peter Brzezinski1 (1Stockholm Univ. Fac. of Nat. Sci., 2Hokkaido Univ.
Fac. of Sci.)
QM/MM 法によるニワトリ卵⽩リゾチームの糖加水分解反応シミュレーション
QM/MM Study on Hydrolysis of Polysaccharides in Hen Egg-White Lysozyme
Takuya Uto1, Yoshiki Mitani2, Toshifumi Yui2 (1Organization for Promotion of Tenure Track, Universityof Miyazaki, 2Faculty of Engineering, University of Miyazaki)– S129 –蛋⽩質：計測・解析／Protein: Measurement & Analysis
2Pos062

2Pos063

2Pos064

2Pos065

2Pos066

2Pos067

2Pos068

2Pos069

幾何学に基づく新しいタンパク質構造解析プログラム
A new program to analyze protein structures based on the geometric context
Anri Terabayashi1, Momoka Nakamura1, Kyosuke Sakata1, Takuya Miyakawa2, Masaru Tanokura2,
Tohru Terada3, Masaki Kojima1 (1Sch. Life Sci., Tokyo Univ. Pharm. Life Sci., 2Grad. Sch. Agric. Life Sci.
Univ. Tokyo, 3III, Univ. Tokyo)
細胞質中 RAF 分子の構造およびダイマー化状態を捉える 1 分子計測
Conformational and dimeric states of cytosolic RAF detected by single-molecule measurements
Kenji Okamoto1, Kayo Hibino2, Yasushi Sako1 (1RIKEN CPR, 2NIG)
信号変化の順序決定の自動化およびタンパク質 HD 交換ダイナミクスの振動バンドへの応用
Automatic determination of the sequential order of signal changes and its application tovibrational bands of protein H-D exchange process
Daisuke Miyata1, Takakazu Nakabayashi1, Shinichi Morita2 (1Graduate School of Pharmaceutical
Sciences, Tohoku University, 2Graduate School of Science, Tohoku University)
水素高感度解析を実現するタンパク質中性子回折実験の進歩
Progress of the protein neutron diffractometry to realize hydrogen high sensitivity analysis
Ichiro Tanaka (Graduate School of Science and Engineering, Ibaraki University)
Flexible Fitting of Biomolecular Structures to Atomic-Force-Microscopy Images via Biased
Molecular Simulations
Toru Niina, Sotaro Fuchigami, Shoji Takada (Grad. Sch. Sci. Univ. Kyoto)
Deep convolutional neural networks for identifying cryo-EM grid holes suitable for particle
collection
Yuichi Yokoyama1, Tohru Terada3, Kentaro Shimizu2,3, Kazutoshi Tani4 (1GSII, Univ. Tokyo, 2Grad. Sch.
Agr. Life Sci., Univ. Tokyo, 3III, Univ. Tokyo, 4Grad. Sch. Med., Univ. Mie)アクチン線維に張力を発生させると線維の長軸まわりのねじれは減少する
Mechanical stress declined the amplitude of the torsional fluctuations of single actin filaments
Kaoru Okura, Takumi Fukuda, Hitoshi Tatsumi (Department of Applied Bioscience, Kanazawa Inst. ofTechnol., Ishikawa, Japan)
高速 AFM 画像のドリフト除去法の応用
Application of drift elimination method for high-speed AFM images
Shotaro Tsujioka1, Hideji Murakoshi2, Mikihiro Shibata3,4 (1Division of Transdisciplinary
Sciences,Graduate School of Frontier Initiative,Kanazawa University, 2National Institute for Physiological,
3WPI Nano Life Science Institute (WPI-NanoLSI),Kanazawa University, 4Institute for Frontier Science
Initiative,Kanazawa University)
蛋⽩質工学／Protein: Engineering

2Pos070* ポリプロリンロッドの挿入によるドメインスワッピング二量体のデザイン
Poly-proline rod insertion for the design of domain-swapped dimer
Shota Shiga1, Masaru Yamanaka2, Wataru Hujiwara1, Shun Hirota2, Shuichiro Goda3, Koki Makabe1(1Graduate School of Science and Engineering, Yamagata University, 2Division of Materials Science, Nara
Institute of Science and Technology, 3Graduate School of Engineering, Nagasaki University)
2Pos071* c-Myb-KIX 相互作用を阻害するペプチドの計算機によるデザイン
Computational design of a peptide inhibitor targeting c-Myb-KIX interaction
Shunji Suetaka1, Yoshiki Oka1, Tomoko Kunihara1, Yuuki Hayashi1, Munehito Arai1,2 (1Dept. Life Sci.,
Univ. Tokyo, 2Dept. Phys., Univ. Tokyo)– S130 –2Pos072* 超安定タンパク質構造のゼロからの合理設計とその融合による、GPCR 構造の合理的安定化
Tailor-made design of superstable proteins from scratch for rational stabilization of GPCR
Masaya Mitsumoto1,2, Nanao Suzuki3, Ryosuke Nakano3, Takahiro Kosugi1,2,4, Takeshi Murata3,
Nobuyasu Koga1,2,4 (1ExCELLS, NINS, 2SOKENDAI, 3Fac. of Sci., Chiba Univ., 4IMS, NINS)
2Pos073* 理論的飽和変異解析によるジヒドロ葉酸還元酵素の高活性化
Improving activity of dihydrofolate reductase by theoretical saturation mutagenesis
Kazuhisa Ohara1, Yoshiki Oka1, Yuuki Hayashi1, Munehito Arai1,2 (1Dept. Life Sci., Univ. Tokyo, 2Dept.
Phys., Univ. Tokyo)
2Pos074* Engineering of genome editing protein Cas9 that slides along DNA faster and might enableefficient target search
Trishit Banerjee1,2, Dwiky Rendra Graha Subekti1,3, Hiroto Takahashi1, Satoshi Takahashi1,
Kiyoto Kamagata1 (1IMRAM, Tohoku Uni., 2Fac. of Sci., Tohoku Uni., 3Grad. Sch. of Sci., Tohoku Uni.)
2Pos075 (2SGP-8) 天然変性タンパク質 p53 を標的としたペプチドの人工設計－液液相分離の制御－(2SGP-8) Rational design of peptide targeting intrinsically disordered protein p53—regulation offunction and phase-phase separation—
Kiyoto Kamagata1, Eriko Mano1, Yuji Itoh1, Saori Kanbayashi1, Masaya Honda1, Ryo Kitahara2,
Tomoshi Kameda3 (1IMRAM, Tohoku Univ., 2Coll. Pharmacy Sci., Ritsumeikan Univ., 3AIRC, AIST)
2Pos076 膜内・膜外領域の改変によるサーモフィリックロドプシンの熱安定化
Further Thermo-Stabilization of Thermophilic Rhodopsin through Engineering in Intramembrane
and Extramembrane Regions
Tomoki Akiyama1, Naoki Kunishima2, Masako Hirose3, Sayaka Nemoto4, Stoshi Yasuda4,5,6, Yuki Sudo7,
Takeshi Murata4,6 (1Grad. Sch. Sci. & Eng., Univ. Chiba, 2RIKEN RSC-Rigaku Collaboration Center,3Malvern Panalytical division of Spectris Co., Ltd, 4Grad. Sch. Sci., Univ. Chiba, 5Inst. Advanced Energy,
Univ. Kyoto, 6Molecular Chirality Research Center, Chiba University, 7Grad. Sch. Med. Dent. Pharm. Sci.,
Univ. Okayama)
2Pos077 麹菌菌体外放出系の高機能化
Improvement of exocytotic secretion system of Aspergillus oryzae
Mone Kogure, Kensuke Nakajima, Yoshinori Tsuji, Yusuke Matsuda (Dept.Biosci., Grad.Sch.Sci.Tech.,
Kwansei Gakuin Univ.)
2Pos078 細胞特異的ゲノム編集を目的とした核酸をデリバリーする新規一本鎖抗体 scFv の作製
Preparation of a novel single chain variable fragment (scFv) which delivers nucleic acid for cellspecific genome editing
Haruka Nasu1, Yuji Sato1, Takashi Tsukamoto2,3, Takashi Kikukawa2,3, Makoto Demura2,3,
Tomoyasu Aizawa2,3 (1Grad. Sch. Life Sci. Hokkaido Univ., 2Fac. Adv. Life Sci. Hokkaido Univ., 3GSS, GICoRE)
ヘム蛋⽩質／Heme proteins
2Pos079

2Pos080

生体反応場におけるシトクロム c 内多核ヘムの空間配置・酸化還元状態の変化
Cellular environment modulates geometry and redox state of deca-heme cofactors in bacterial
surface cytochromes
Yoshihide Tokunou1,2,3, Shingo Hattori4, Thomas Clarke5, Liang Shi6, Kazuyuki Ishii4, Akihiro Okamoto2(1Faculty of Life. Environ. Sci., Uni. Tsukuba, 2NIMS, 3Research Fellow of JSPS, 4Inst. Indust. Sci., Univ.
Tokyo, 5Centre for Molecular and Structural Biochemistry, Univ. East Anglia, 6Dept. of Biological
Sciences, China Univ. of Geosciences)NO-binding and protonation process in the catalytic reaction of the bacterial NO reductase as
established by time-resolved spectroscopy
Hanae Takeda1,2, Tetsunari Kimura3, Takashi Nomura1, Takehiko Tosha2, Yoshitsugu Shiro1,
Minoru Kubo1 (1Grad. Sch. Sci., Univ. Hyogo, 2RIKEN, SPring-8 Center, 3Grad. Sch. Sci., Kobe Univ)– S131 –2Pos081

Anodized gold surface enables mediator-free bioelectrocatalysis of redox enzymes
Yasuhiro Mie, Yoshiaki Yasutake, Mashiki Ikegami, Tomohiro Tamura (Bioproduction Res. Inst., AIST)
膜蛋⽩質／Membrane proteins

2Pos082* 膜蛋⽩質複合体の構造ダイナミクスへコレステロールが及ぼす影響に関する分子動力学的解析
Influences of cholesterol on structural dynamics of membrane protein complexes studied bymolecular dynamics simulations
Hayato Itaya1, Kota Kasahara2, Yoshiaki Yano3, Katsumi Matsuzaki3, Takuya Takahashi2 (1Grad. Sch.
Life Sci., Ritsumeikan Univ, 2Coll. Life Sci., Ritsumeikan Univ., 3Grad. Sch. Pharm.Sci., Kyoto Univ)
2Pos083* Observation of a β-Hairpin Peptide in α-Hemolysin Nanopore
Misa Yamaji, Ryuji Kawano (Tokyo University of Agriculture and Technology)
2Pos084* 表面プラズモン共鳴法を用いた膜タンパク質に特異的な脂質の同定: 脂質の生理機能解明を目指
してIdentification of membrane proteins-specific lipids using surface plasmon resonance analysis:
For elucidating the physiology of lipids
Masataka Inada1, Masanao Kinoshita1, Masayuki Iwamoto2, Shigetoshi Oiki2, Nobuaki Matsumori1(1Grad. Sch. Sci., Kyushu Univ., 2Fac. Med. Sci., Univ. Fukui)
2Pos085 クライオ電子顕微鏡による組換リアノジン受容体の高分解能構造
High-resolution cryo-EM structures of recombinant ryanodine receptors
Takuya Kobayashi2, Akihisa Tsutsumi3, Kei Saito4, Takashi Sakurai2, Masahide Kikkawa3,
Takashi Murayama2, Haruo Ogawa1 (1IQB, The Univ. Tokyo, 2Juntendo Univ. Grad. Sch. Med., 3Grad.
Sch. Med., Univ. Tokyo, 4Grad. Sch. Arts Sci., Univ. Tokyo)
2Pos086 Exploring Structural Dynamics of Bacterial ABC Transporter MsbA by High Speed AFM
Kien X. Ngo, Holger Flechsig, Noriyuki Kodera, Toshio Ando (WPI Nano Life Science Institute, Kanazawa
University)
2Pos087 Corynebacterial “Force-From-Lipids” mechanosensation for glutamate production
Yoshitaka Nakayama1, Ken-ichi Hashimoto2,3, Hisashi Kawasaki2,3, Boris Martinac1,4 (1Victor Chang
Cardiac Research Institute, 2Biotech. Res. Cen., Univ. Tokyo, 3Collab. Res. Ins. Inno. Microbiol., Univ.
Tokyo, 4University of New South Wales)
2Pos088 The assembly of the trimeric autotransporter transmembrane domain into BamA-embedded
nanodiscs
Eriko Aoki, Kazuo Fujiwara, Masamichi Ikeguchi (Dept. of Bioinfo., Soka Univ.)
核酸結合蛋⽩質／Nucleic acid binding proteins
2Pos089

2Pos090

2Pos091

2Pos092

CRISPR Cas3 と Cse1 複合体の分子動力学シミュレーション
Molecular dynamics simulations of CRISPR Cas3 and Cse1 complex
Tomohiro Yamaguchi, Yui Taketomo, Naoyuki Miyashita (BOST KINDAI Univ.)
Identification of proteins that interact with nucleosomes by Quantitative Proteomics
Lumi Negishi1, Hiroki Tanaka2, Rina Hirano1, Tomoya Kujirai1, Hitoshi Kurumizaka1 (1IQB, Univ. Tokyo,
2Grad. Adv. Sci. Eng., Waseda Univ.)
転写因子の振る舞いとクロマチンのゆらぎの関係性を 1 分子計測によって解析する
Single molecular dynamics of transcription factors are controlled by diffusion movement ofchromatin
Kazuko Okamoto1, Yasushi Okada1, Kuniya Abe2, Tomonobu M Watanabe1 (1RIKEN BDR, 2RIKEN
BRC)
DNA 二重鎖切断に応答した DNA トポイソメラーゼ 2B の核内挙動
Dynamic behavior of DNA topoisomerase 2B in response to DNA double-strand breaks
Ken ichi Yano, Keiko Morotomi-Yano (IPPS, Kumamoto Univ.)– S132 –核酸／Nucleic acid
2Pos093* 人工細胞デバイス内に封入した長鎖 DNA 1 分子からの遺伝子発現
Gene expression from a single large DNA encapsulated in artificial cell device
Yuto Ochiai1, Hiroshi Ueno1, Masayuki Su'etsugu2, Hiroyuki Noji1 (1Dept. Appl. Chem., Grad. Sch. Eng.,
Univ. Tokyo, 2Dept. Life Sci., Col. Sci., Rikkyo Univ.)
2Pos094* 生体ナノポアフィルタを用いた DNA の一分子分離
Separation of a single molecule DNA using biological nanopore filter
Asuka Tada, Ryuji Kawano (Department of Biotechnology and Life Science, Tokyo University ofAgriculture and Technology)
2Pos095* DETECTION OF DNA-POINT-MUTATION USING BIOLOGICAL NANOPORE
Ping Liu, Keisuke Shimizu, Ryuji Kawano (Tokyo University of Agriculture and Technology)
2Pos096 DNA を利用した人工分子モーターの実現を目指して
Towards the realization of artificial molecular motor using DNA molecules
Kohei Arai, Yuki Tsushima, Shoichi Toyabe (Appl. Phys., Tohoku Univ.)
2Pos097 染色体脱凝縮シミュレーションによるヒト間期核組織化の理解
Organization of interphase human nucleus via simulated chromosome decondensation
Shin Fujishiro, Masaki Sasai (Dept. Appl. Phys., Nagoya Univ.)
2Pos098 クロマチン構造と RNA 輸送経路が協調して形成される過程
Cooperative formation of RNA transporting pathway and chromatin structure
Nozomu Imai, Shin Fujishiro, Masaki Sasai (Dept. Appl. Phys., Nagoya Univ.)
2Pos099 染色体のナノスケール 3 次元内部構造を可視化するための液中 3 次元原子間力顕微鏡（3D-AFM）の開発
Development of 3D-AFM to visualize nanometer-scale three-dimensional structures ofchromosomes in liquid
Keisuke Miyazawa1, Makiko Meguro-Horike2, Shin-ichi Horike2, Takashi Sumikama3, Taku Higasayama1,
Masayuki Harada1, Takeshi Fukuma1,3 (1Kanazawa Univ., 2Division of Functional Genomics, Advanced
Science Research Center, Kanazawa Univ., 3Nano Life Science Institute (WPI-NanoLSI), Kanazawa Univ.)
2Pos100 染色体の 3D-AFM 像と実像の関係の理論的解明
A theoretical study on a relationship between 3D atomic force macroscopy image and structureof chromosomes
Takashi Sumikama1, Keisuke Miyazawa4, Adam Foster1,2,3, Takeshi Fukuma1,4 (1Nano Life Sicence
Institute (WPI-NanoLSI), Kanazawa University, 2Department of Applied Physics, Aalto University,
3Graduate School Materials Science in Mainz, 4Division of Electrical Engineering and Computer Science,
Kanazawa University)
2Pos101 FRET study on sequence-dependent unwrapping of nucleosomal DNA
Tomoko Sunami, Di Luo, Hidetoshi Kono (MMS, iQLS, QST)
2Pos102 DNA メチル化に依存したヌクレオソームのスライディング動態の解析
Computational Analysis of the Nucleosome Sliding Dynamics Depending on DNA Methylation
Takeru Kameda1,2, Miho Suzuki3, Akinori Awazu1,4, Yuichi Togashi1,2,4 (1Department of Mathematicaland Life Sciences, Hiroshima University, 2RIKEN Center for Biosystems Dynamics Research., 3Graduate
School of Medicine, Nagoya University, 4Graduate School of Integrated Sciences for Life, Hiroshima
University.)
分子遺伝・遺伝情報制御／Molecular genetics & Gene expression
2Pos103* 微小空間内における 1 分子からの長鎖 DNA 複製
Large DNA amplification from single molecule in micro-sized droplet
Hiroki Sawada1, Naoki Soga1, Seia Nara2, Masayuki Su'etsugu2, Kazuhito V. Tabata1, Hiroyuki Noji1(1Dept. App. Chem, Univ. Tokyo., 2Dept. Life. Sci., Sol. Sci., Rikkyo Univ.)– S133 –発生・分化／Development & Differentiation
2Pos104* Piezo1 はリンパ管弁形成過程におけるカルシウムシグナルに必要である
Piezo1 is required for calcium signaling during lymphatic valve morphogenesis
Hiroki Katsuta1,2, Keiko Nonomura2, Akemi Kanie2, Takaki Miyata1, Toshihiko Fujimori2 (1Grad. Sch.
Med. Nagoya Univ. Cell Biol., 2NIBB Embryology)
2Pos105 血管新生における血管内皮細胞の往復運動
Linear reciprocating movement of vascular endothelial cells in angiogenesis
Naoko Takubo1, Kazuaki Naemura2, Ryo Yoshida3, Terumasa Tokunaga4, Hiroki Kurihara2 (1Isotope
Science Center, Univ. Tokyo, 2Grad. Sch. Med., Univ. Tokyo, 3Inst. Statistical Mathematics, 4Faculty ofComputer Science and Systems Engineering, Kyushu Inst. Tec.)
2Pos106 ドリフトのあるランダム運動がヒトの胚葉形成には必要である
Brownian motion with drift is essential for forming human germ layers
Kenshiro Maruyama, Ryo Kobayashi, Haru Hikita, Tadashi Tsubone, Kiyoshi Ohnuma (Nagaoka
University of Technology)
2Pos107 確率的な細胞たちが協調して正確な大きさの体節を作る仕組み ～分節時計によるノイズキャンセ
ル機構～
Noise-resistant developmental reproducibility in vertebrate somite formation
Naoki Honda1,2, Ryutaro Akiyama2, Dini WK Sari2, Bessho Yasumasa2, Takaaki Matsui1,2 (1Grad. Sch.
Biostudies., Kyoto Univ., 2NAIST)
2Pos108 エネルギー地形アプローチに基づく組織形態形成の多様性と安定性の探求
Exploring variety and robustness in tissue morphogenesis based on energy landscapeapproach
Yoshitaka Kameo1,2,3, Hironori Takeda2, Taiji Adachi1,2,3 (1IFLMS, Kyoto Univ, 2Grad Sch Eng, Kyoto
Univ, 3Grad Sch Bio, Kyoto Univ)
2Pos109 三次元粒子画像流速測定法によるノード流の解析
Analysis of nodal flow by three-dimensional particle image velocimetry
Atsushi Taniguchi1,2, Yukinori Nishigami3, Shigenori Nonaka1,2 (1Spatiotemp. Reg., NIBB, 2ExCELLS,
3RIES, Hokkaido Univ.)
筋肉／Muscle
2Pos1102Pos1112Pos1122Pos113

Mechanical stress-responsive membrane remodeling in muscle cells
Kenshiro Fujise, Hiroshi Yamada, Kohji Takei, Tetsuya Takeda (Okayama Univ. Grad. Sch. Med. Dent.
Pharm. Sci.)
無機ポリリン酸存在下でのアクチン重合
Polymerization of actin molecules in the presence of inorganic polyphosphate
Koji Ito, Kuniyuki Hatori (Grad. Sch. Sci. Eng. Yamagata Univ.)
Visualization of Ca2+ regulated structural change in muscle thin filament by cryoEM
Yurika Yamada, Keiichi Namba, Takashi Fujii (Grad. Sch. of Frontier Biosci., Osaka Univ.)
Fhod3 と cMyBP-C による心筋サルコメアの形成および維持機構
Mechanism of construction and maintenance of cardiac sarcomeres by Fhod3 and cMyBP-C
Wataru Kedouin1, Riho Takiiwa1, Nao Shimojo1, Ryu Takeya2, Takuo Yasunaga1 (1Grad. Sch. of Comp.
Sci. and Sys. Eng., Kyushu Inst. of Tech., 2Dept. of Pharma., Univ. of Miyazaki)– S134 –分子モーター／Molecular motor
2Pos114* DNA オリガミを用いたナノバネ結合心筋ミオシンフィラメントの 1 分子解析
Single molecule analysis of DNA origami-based cardiac myosin filaments attached with
Nanospring
Hiroki Fukunaga1, Masashi Ohmachi2, Keisuke Fujita2, Keigo Ikezaki3, Toshio Yanagida1,2,
Mitsuhiro Iwaki1,2 (1FBS, Univ. Osaka, 2BDR, Riken, 3Grad. Sch. Sci., Univ. Tokyo)
2Pos115* 細胞質ダイニンの運動方向性を左右するアミノ酸の同定
Key residues on cytoplasmic dynein for asymmetric unbinding from microtubule
Shintaroh Kubo1, Tomohiro Shima2, Takahide Kon3, Shoji Takada1 (1Grad. Sch. Sci., Univ. Kyoto, 2Grad.
Sch. Sci., Tokyo Univ., 3Grad. Sch. Sci., Univ. Osaka)
2Pos116* 好熱菌由来 F1-ATPase の至適生育温度における力学的仕事の測定
The Measurement of Mechanical Work of Thermophilic F1-ATPase at the Optimum Growth
Temperature
Tomoaki Okaniwa1, Yohei Nakayama2, Naoya Terahara1, Eiro Muneyuki1 (1Dept. Phys., Graduate Schoolof Science and Engineering, Chuo Univ., 2Dept. Appl. Phys., Graduate School of Engineering, Tohoku
University)
2Pos117* 中間鎖をアンカーとした新しい運動アッセイ法によるクラミドモナス軸糸ダイニン集団の運動特性の計測
Collective motility of Chlamydomonas outer arm dynein measured using its intermediate chain
as a scaffold for motility assays
Yuka Matsuda1, Akane Furuta2, Hiroaki Kojima2, Kazuhiro Oiwa1,2, Ken'ya Furuta2 (1Grad. Sch. Sci.,
Univ. Hyogo, 2Adv. ICT Res. Inst., NICT)
2Pos118 The combination of high-speed atomic force microscopy and X-ray crystallography reveals
rotary catalysis of a shaftless V1 motor
Shintaro Maruyama1, Motonori Imamura2, Takayuki Uchihashi3,4, Kazuya Nakamoto1, Kenji Mizutani5,
Lica Fabiana Imai1, Kano Suzuki1, Yoshiko Ishizuka-Katsura6, Tomomi Someya-Kimura6,
Mikako Shirouzu1,6,7, Ichiro Yamato1,7, Toshio Ando2, Takeshi Murata1,8 (1Grad. Sch. Sci., Univ. Chiba,
2WPI Nano Life Sci. Inst., Univ. Kanazawa, 3JST, CREST, 4Dep. Phys., Univ. Nagoya, 5Grad. Sch. Med.
Life. Sci., Univ. Yokohama, 6DSSB, RIKEN, 7Ind. Sci. Tokyo Univ. Sci., 8PREST, JST)
2Pos119* Measurement of force generation by dynein ensemble on a doublet microtubule obtained from
sperm flagella
Takashi Fujiwara1, Chikako Shingyoji1, Hideo Higuchi2 (1Dept. Biol. Sci., Grad. Sch. Sci., Univ. Tokyo,
2Dept. Phys., Grad. Sch. Sci., Univ. Tokyo)
2Pos120* 1 分子計測による腸内連鎖球菌由来の回転分子モーター V1-ATPase の化学力学共役機構の解明
Chemo-mechanical coupling scheme of rotary molecular motor Enterococcus hirae V1-ATPase
revealed by single-molecule analysis
Tatsuya Iida1,2, Yoshihiro Minagawa3, Hiroshi Ueno3, Fumihiro Kawai4, Takeshi Murata5, Ryota Iino1,2(1SOKENDAI (The Grad. Univ. for Adv. Stud.), 2Inst. for Mol. Sci., 3The Univ. of Tokyo, 4Yamagata Univ.,
5Chiba Univ.)
2Pos121 (2SDA-7) Dynamic energy landscape of a linear motor chitinase from single-particle tracking
trajectories
Kei-ichi Okazaki, Akihiko Nakamura, Ryota Iino (Institute for Molecular Science)
2Pos122 アクチンの pH 依存的な荷電状態と分子間相互作用
pH-dependent charge-state and intermolecular interaction of actin
Jun Ohnuki, Mitsunori Takano (Dept. of Pure & Appl. Phys., Waseda Univ.)– S135 –2Pos123

2Pos124

2Pos125

2Pos126

2Pos127

2Pos128

2Pos129

2Pos130

2Pos1312Pos132

2Pos133

枯草菌べん毛モーターの回転ステップ解析
Step analysis of the Bacillus Na+-driven flagellar motor
Naoya Terahara1,2, Miku Yoh3, Eiro Muneyuki1, Keiichi Namba2,4, Tohru Minamino2 (1Dept. Phys., Chuo
Univ., 2Grad. Sch. Frontier Biosci., Osaka Univ., 3Fac. Human Life Sci., Doshisha Women's Col., 4BDR/
RSC, Riken)
アクチン繊維の集団運動により形成されるベルトパターンはリング状に変化する
Transformation of belt-like to ring patterns of a quasi-concentrated solution of F-actin driven by
myosin-coated surface
Kentaro Ozawa1, Mikiya Amano1, Hirotaka Taomori1, Itsuki Kunita2, Shigeru Sakurazawa3,
Hajime Honda1 (1Dept. Bioeng., Nagaoka Univ. Tech., 2Univ. Ryukyus, 3Future Univ. Hakodate)
Myosin II decreases the connectivity of an actin network using two different mechanisms
depended on concentration of crosslinking protein
Kyohei Matsuda1, Takuya Kobayashi1,2, Mitsuhiro Sugawa1, Masahiko Yamagishi1, Yoko Y. Toyoshima1,
Junichiro Yajima1 (1Department of Life Sciences, Graduate School of Arts and Sciences, The University ofTokyo, 2Juntendo University)
Developing the detection system of the conformational change in rotating flagellar motor by
single motor FRET
Takuma Nakagawa, Tatsuya Yamakoshi, Yong-Suk Che, Akihiko Ishijima, Hajikme Fukuoka (Grad. Sch.
Frontier Biosci., Osaka Univ.)
ダイニン・微小管・DNA 折り紙複合体の振動的運動
Oscillatory movement of the dynein-microtubule complex crosslinked with DNA-origami
Shimaa A. Abdellatef1, Hisashi Tadakuma2, Yuichi Kondo3, Kangmin Yan1, Hideo Higuchi3,
Keiko Hirose1 (1Biomed. Res. Inst., AIST, 2IPR, Osaka Univ., 3Grad. Sch. Sci., Univ. Tokyo)
Ca2+濃度変化による真核生物鞭毛軸糸の構造変化の X 線繊維回折解析
Structural changes of Chlamydomonas and Ciona flagellar axonemes coupled with the change
in [Ca2+] studied with X-ray fiber diffraction
Kazuhiro Oiwa1, Hiroyuki Iwamoto2, Kogiku Shiba3, Kazuo Inaba3, Hitoshi Sakakibara1 (1Adv. ICT Res.
Inst., NICT, 2JASRI, 3Shimoda Marine Res. Cent. Univ. Tsukuba)
新規繊毛ダイニン軽鎖 MOT7 の構造機能解析
Structural/functional analyses on MOT7, a novel light chain of ciliary dynein f/I1
Ryosuke Yamamoto1, Yuuhei Nakagiri1, Osamu Kutomi2, Hiroshi Imai1, Chihong Song3,
Kazuyoshi Murata3, Ken-ichi Wakabayashi4, Takashi Ishikawa5, Kazuo Inaba6, Takahide Kon1 (1Osaka
Univ., 2Univ. of Yamanashi, 3NIPS, 4Tokyo Tech, 5PSI, 6Univ. of Tsukuba)
全反射赤外分光法を用いた共役イオン結合による Na+駆動型モーター固定子の構造変化の解明
The cation-induced structural changes in the Na+-driven flagellar stator studied by ATR-FTIR
Masayo Iwaki1, Tatsuro Nishikino2, Hiroyuki Terashima2, Michio Homma2, Hideki Kandori1 (1Nagoya
Inst. Tech., 2Nagoya Univ.)
2 つのアゾベンゼンを持つフォトクロミック Eg5 阻害剤存在下における Eg5 活性の光制御機構の研究
Study on inhibitory mechanism of kinesin Eg5 with photochromic Eg5 inhibitor composed of two
azobenzene
Kei Sadakane1, Islam MD Alrazi2, Kenichi Taii2, Tomisin H. Ogunwa3, Shinsaku Maruta1,2 (1Sci. & Eng.,
Soka Univ., 2Grad. Sch. Eng., Soka Univ., 3Grad. Sch. Fisheries and Environmental Sci., Nagasaki Univ.)
結晶性キチン加水分解酵素は背水の陣で進むブラウニアンモーターである
Crystalline chitin hydrolase is a Burnt-bridge Brownian motor
Akihiko Nakamura1,2, Kei-ichi Okazaki1, Tadaomi Furuta3, Minoru Sakurai3, Ryota Iino1,2 (1Institute for
Molecular Science, 2SOKENDAI, 3Tokyo Institute of Technology)
プログラマブルな DNA オリガミによる微小管格子構造の制御
Defining microtubule lattice structure using programmable DNA-origami seeds
Daisuke Inoue, Franky Djutanta, Rizal Hariadi (Biodesingn Institute, Arizona State Univ.)– S136 –2Pos134

2Pos135

2Pos136

2Pos137

2Pos138

Plus-end directionality is present in the conserved catalytic motor core of kinesin-14 minus-end
directed motors
Masahiko Yamagishi, Junichiro Yajima (Dept. Life Sci., Grad. Arts & Sci., Univ. Tokyo)
DNA オリガミの分子配置技術を用いたキネシン分子の協調性評価
Evaluating coordination between kinesin motors using DNA origami-based transport complex
Kodai Fukumoto1, Yuya Miyazono2, Hisashi Tadakuma1, Yoshie Harada1 (1IPR, Osaka Univ., 2Grad. Sch.
Front. Sci., Univ. Tokyo)
KIF1A/UNC-104 によるシナプス小胞前駆体輸送の数理モデル
Mathematic modeling of synaptic vesicle precursor transport by KIF1A/UNC-104
Ryo Sasaki1, Ryota Shinagawa1, Kazuo Sasaki1, Shinsuke Niwa2, Kumiko Hayashi1,3 (1Dep. Appl. Phys.,Grad. Sch. of Eng., Tohoku Univ., 2FRIS, Tohoku Univ., 3JST, PRESTO, Tokyo, Japan)
遺伝性痙性対麻痺を引き起こす変異型ヒト KIF1A の運動特性
Motility characteristics of human KIF1A mutants in hippocampal neurons in relation tohereditary spastic paraplegia
Shiori Matsumoto1, Kyoko Chiba2, Shinsuke Niwa3, Kumiko Hayashi1,4 (1Dep. Appl. Phys., Grad. Sch. ofEng., Tohoku Univ., 2Col. Biol. Sci., UC Davis, 3FRIS, Tohoku Univ., 4PRESTO, JST)
キネシン 1 の連続的移動距離を決める要因の高速一分子観察
Determinant of the processivity of kinesin-1 as studied using high-speed single-molecule
observations
Tsukasa Enomoto1, Kohei Matsuzaki2, Michio Tomishige2 (1Grad. Sch. Sci. Eng., Aoyama Gakuin Univ.,
2Dept. Math. Phys., Col. Sci. Eng., Aoyama Gakuin Univ.)
細胞生物的課題／Cell biology

2Pos139* 集団運動する神経幹細胞で測定された牽引力の、細胞配向場によるモデリング
Traction Force of Neural Stem Cells under Collective Migration was Modeled using theOrientation Field of Cell Alignment
Masahito Uwamichi1, Kyogo Kawaguchi2, Masaki Sano3,4 (1Dept. of Phys, Univ. of Tokyo, 2RIKEN BDR,
3IIAS, 4TOKYO COLLEGE)
2Pos140* 細胞集団の 3D 自己組織化: 高分子溶液の水／水ミクロ相分離の活用
Self-Generating 3D Cellular Assembly: Aqueous/Aqueous Micro Droplet as a Non-invasive
Scaffold
Ritsuki Ito, Toshifumi Kishimoto, Takahiro Kenmotsu, Koichiro Sadakane, Kenichi Yoshikawa (Graduate
School of Life Medical Science, Doshisha University)
2Pos141* ナノ粒子を用いた細胞内局所加熱に対する細胞の応答
Responses of cells to local heating in cells using a nanoparticle
Hideaki Ota, Hideo Higuchi (Phys., Grad. Sci., Univ. Tokyo)
2Pos142* Quantitation of cell shape by machine learning
Masato Tsutsumi1, Chikara Furusawa2,3, Satoshi Sawai4, Nen Saito2 (1Grad School of Science, The Univ.
of Tokyo, 2Universal Biology Institute, The Univ. of Tokyo, 3Center for Biosystems Dynamics Research,
RIKEN, 4Graduate School of Arts and Sciences, The Univ. of Tokyo)
2Pos143* 細胞接着形態振動を駆動するグラフトポリマー層の垂直/水平変形性とその相関解析
Dual characterizations of vertical/lateral deformation of grafted-polymer layer driving cell-shapeoscillation
Sayaka Masaike1, Satoru Kidoaki2 (1Grad. Sch. Eng., Kyushu Univ., 2IMCE, Kyushu Univ.)
2Pos144* 鍵アミノ酸残基を含む領域に変異をもつべん毛繊維の in vitro 多型変換実験
In vitro polymorphic transformation of flagellar filaments with mutations in a domain including
the key amino acids
Shiori Hirose1, Hidetoshi Tomaru1, Yuuka Sashida1, Yuka Kobayashi1, Kana Horiguchi1,
Mikako Tsubaki1, Fumio Hayashi2, Kenji Oosawa1 (1Gunma Univ, Grad. Sch. Sci. Technol, 2Gunma Univ,
Ctr. Instr. Anal)– S137 –2Pos145* マイコプラズマニューモニエの走流性
Rheotaxis in Mycoplasma pneumoniae
Yoshiki Kabata, Daisuke Nakane, Takayuki Nishizaka (Department of Physics, Gakushuin University)
2Pos146* 細胞内で LLPS 現象を観察する簡単な方法の開発
Development of a simple method to observe LLPS in cells
Chaieun Kim1, Kohki Okabe1,2, Takashi Funatsu1 (1Grad. Sch. of Pharm. Sci., The Univ. of Tokyo.,
2PRESTO, JST)
2Pos147 (2SCP-5) Morphodynamic feature space of migrating cells
Daisuke Imoto1, Nen Saito2, Satoshi Sawai1,3 (1Graduate School of Arts and Sciences, University of Tokyo,
2Universal Biology Institute, Graduate School of Science, University of Tokyo, 3Research Center for
Complex Systems Biology, University of Tokyo)
2Pos148 バクテリア集団運動の揺らぎと応答の測定
Measurement of fluctuation and response of bacterial collective motion
Tatsuro Kai, Takahiro Abe, Shuichi Nakamura, Seishi Kudo, Shoichi Toyabe (Appl. Phys., Tohoku Univ.)
2Pos149 細胞運動のメカノケミカルモデル
Mechanochemical modelling of crawling cells
Mitsusuke Tarama1, Kenji Mori2, Ryoichi Yamamoto2,3 (1RIKEN BDR, 2Dep Chem Eng, Kyoto Univ, 3IIS,
Univ Tokyo)
2Pos150 Quantitative Analysis of Signal-dependent Cell Cycle Regulation
Kyoichi Ebata, Hiroaki Imoto, Sawa Yamashiro, Mariko Okada (IPR, Osaka Univ.)
2Pos151 飢餓状態への過渡期における大腸菌集団の束状凝集と一細胞形態
Bundle structure and single-cell morphology in E. coli populations during transient to a
starvation condition
Takuro Shimaya1, Reiko Okura2, Yuichi Wakamoto2, Kazumasa A. Takeuchi1,3 (1Dept. of Phys., Univ.
Tokyo, 2Dept. of Basic Sci., Univ. Tokyo, 3Dept. of Phys., Tokyo Tech)
2Pos152 Adaptability and robustness of cell migration realized by size-dependent polarity dynamics
Akihiko Nakajima1,2, Motohiko Ishida2, Satoshi Sawai2,3 (1Dept. Gen. Sys. Studies, Grad. Sch. Arts & Sci.,
Univ. Tokyo, 2Res. Cent. Comp. Sys. Biol., Univ. Tokyo, 3Dept. Basic Sci, Grad. Sch. Arts & Sci., Univ.
Tokyo)
2Pos153 3 次元毛細管構造のトポロジーが血管内皮細胞のシート展開の振る舞いを決定する
Topology of three-dimensional capillary structure determines blood vein sheet extension
behavior
Kento Iida1, Hiromichi Hashimoto1, Masao Odaka2, Akihiro Hattori2, Kenji Yasuda1,2 (1Dept. Pure &Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 2Org. Univ. Res. Initiatives, Waseda Univ.)
2Pos154 血管内皮細胞の二次元平面構造内における単一細胞の運動特性の観察
Behavior of single vascular endothelial cells in 2D structures
Hiromichi Hashimoto1, Yuki Yamanaka1, Ryuji Takano2, Kento Iida1, Masao Odaka3, Kenji Matsuura3,
Akihiro Hattori3, Kenji Yasuda1,2,3 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ.,
2Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda
Univ.)
2Pos155 FRET を用いた「CheYp 濃度変化」と「べん毛モーターの回転方向」の同時計測
Simultaneous measurement of flagellar motor rotation and CheYp concentration via single cell
FRET
Tatsuya Yamakoshi, Yong-Suk Che, Akihiko Ishijima, Hajime Fukuoka (Grad.Sch.Frontier.Osaka Univ.)
2Pos156 低浸透圧下における金魚ケラトサイト細胞シートの移動速度の上昇
Enhanced movement of fish keratocytes cell-sheet under low osmotic conditions
Naoto Ishijima, Hitoshi Tatsumi (Human Information Systems Laboratory, Kanazawa Institute ofTechnology)
2Pos157 A multi-omic approach to predict gene expression and metabolic functions from label-free
spectral imaging of living cells
Arno Germond, Vipin Kumar, Tomonobu M. Watanabe (RIKEN BDR)
– S138 –2Pos158

2Pos159

2Pos160
2Pos161

2Pos162

2Pos163

2Pos164

2Pos165

Conduction Pathway Analysis of Line-Networked Cardiomyocytes By using Multi-ElectrodeArray System
Tetsuro Yoshida, Tomoyuki Kaneko (LaRC, FB, Grad. Sci.&Eng., Hosei Univ.)
原子間力顕微鏡を用いた悪性度が異なるがん細胞の細胞間接着強度の比較
Comparison of intercellular adhesion strengths of cancer cells having different malignancies
studied by atomic force microscopy
Kenta Ishibashi1,2, Tomoko Okada1, Chikashi Nakamura1,2,3, Hyonchol Kim1,2,3 (1Biomed. Res. Inst.,
AIST, 2Grad. Sch. Eng., Tokyo Univ. Agric. Technol., 3PhotoBio-OIL, AIST-Osaka Univ.)
Analysis of Physical Effect on Macrophage with Agarose Microchamber
Tomoyuki Irisawa, Nami Morizino, Tomohiro Saito, Tomoyuki Kaneko (LaRC, FB, Hosei Univ.)
擬似心臓モデルとしての直線状心筋・線維芽細胞ネットワークの再構成および電気生理学性質の評価
Reconstruction of cardiac tissue-like cell structure and electrophysiological property evaluation
Koki Fujii, Tomoyuki Kaneko (Grad. Sch. FB LaRC, Hosei Univ.)
多電極電位システムを用いた赤外線レーザー照射による心臓組織片の拍動変化
Beating rate change of heart tissue piece by infrared laser irradiation using Multi ElectrodeArray system
Koji Emura, Tomoyuki Kaneko (LaRC, FB, Grad.Sci&Eng, Hosei Univ.)
ニワトリ胚由来心筋細胞を低温から温度を上げた際の拍動周期の変化
Beating rate change of chick embryonic cardiomyocytes heated up from low temperature
Kohei Oyama, Wei Wang, Tomoyuki Kaneko (LaRC, FB, HOSEI unv.)
心臓組織片の薬剤感受性におけるサイズ依存性の分析
Analysis of sensitivity for drugs depending size of cardiac tissue
Ryohei Kobayashi, Koji Emura, Tomoyuki Kaneko (LaRC,FB,Hosei Univ.)
ハイドロゲル上でのマスト細胞の脱顆粒抑制機構の研究
Inhibition of degranulation in mast cells attached to a hydrogel through defective microtubule
tractsTadahide Furuno, Atsushi Shiki, Satoru Yokawa, Yoshikazu Inoh (Sch. Pharm., Aichi Gakuin Univ.)
生体膜・人工膜／Biological & Artificial membrane: Structure & Property

局所麻酔薬によるラフト様/非ラフト様相分離の解消とその機序
Mechanism of the local anesthetics-induced perturbation of raft-like ordered membrane
domains
Masanao Kinoshita, Takeshi Chitose, Nobuaki Matsumori (Kyushu University)
2Pos167 Comparative study on organizations of human stratum corneum intercellular lipids collectedfrom various body sites
Kenta Moriwaki, Hiromitsu Nakazawa, Satoru Kato (Grad. Sch. Sci & Tech., Univ. Kwansei Gakuin)
2Pos168* 回折 X 線ブリンキング法を用いた生細胞上の GPCR 分子内部運動の決定
Determining Intramolecular Motion of GPCRs on Live Cells using Diffracted X-ray Blinking
Technique
Masaki Ishihara1,2, Shoko Fujimiura2, Kohei Ichiyanagi3,4, Shunsuke Nozawa3, Shinichi Adachi3,
Ryo Fukaya3, Masahiro Kuramochi1,2, Kazuhiro Mio2, Yuji Sasaki1,2 (1Grad Sch. of Fron. Sci., Univ. ofTokyo, 2Univ. of Tokyo - AIST OIL, 3KEK, 4Jichi Med. Univ)
2Pos169* 大腸菌の封入密度に依存したリポソームの形態変化
Morphological changes of liposomes depending on density of encapsulated E. coli
Mai Hayakawa, Hazuki Terajima, Masahito Hayashi, Tomoyuki Kaneko (LaRC, FB, Hosei Univ.)
2Pos166– S139 –2Pos170* 抗菌ペプチド・ラクトフェリシン B が誘起する細胞膜や脂質膜の急速な膜透過には膜電位が重要な役割を果たす
Membrane potential is vital for rapid permeabilization of plasma membranes and lipid bilayersby the antimicrobial peptide lactoferricin B
Farzana Hossain1, Md. Mizanur Moghal1, Md. Zahidul Islam1, Md. Moniruzzaman1,
Masahito Yamazaki1,2,3 (1Grad. Sch. Sci. Tech., Shizuoka Univ., 2Res. Inst. Ele., Shizuoka Univ., 3Grad.
Sch. Sci., Shizuoka Univ.)
2Pos171* 細胞透過ペプチド・トランスポータン 10 の単一ベシクル内腔への侵入に対する膜電位の効果とそのメカニズムEffect of membrane potential on the entry of cell-penetrating peptide transportan10 into thelumen of single vesicles and its mechanism
Md. Mizanur Moghal1, Md. Zahidul Islam1, Samiron Kumar Saha1, Masahito Yamazaki1,2,3 (1Grad. Sch.
Sci. Tech., Shizuoka Univ, 2Res. Inst. Ele., Shizuoka Univ., 3Grad. Sch. Sci., Shizuoka Univ.)
2Pos172 膜タンパク質の分子内部動態解析技術の開発
Understanding intramolecular dynamics of membrane proteins using X-ray based analysis
techniques
Kazuhiro Mio1, Shoko Fujimura1, Masaki Ishihara2, Muneyo Mio1, Masahiro Kuramochi2,
Hiroshi Sekiguchi3, Tai Kubo1, Yuji C. Sasaki2 (1Operand OIL, AIST, 2Grad. Sch. of Front. Sci., The Univof Tokyo, 3JASRI)
2Pos173 リン脂質とアクチンとビーズの互いに結合しないもの同士によるリポソームの形態形成
Liposome morphogenesis by phospholipid, actin filament and polystyrene bead that are notbound to each other
Ryota Kojima1, Tomo Shibuya2, Yutaka Sumino2, Shunsuke Tanaka1, Masahito Hayashi1,
Kingo Takiguchi1 (1Department of Biological Science, Graduate School of Science, Nagoya University,
2Department of Applied Physics, Tokyo University of Science)
2Pos174 タンパク質吸着による脂質膜の基板からの剥離
Membrane detachment from substrate induced by protein adhesion
Hiroshi Noguchi (ISSP, Univ. Tokyo)
2Pos175 エピガロカテキンガレートが誘起する GUV の破裂のメカニズム
Mechanism of the burst of giant unilamellar vesicles induced by epigallocatechin gallate
Yukihiro Tamba1, Mika Terada1, Naoya Sugita1, Masahito Yamazaki2 (1Natl Inst Tech, Suzuka Coll,
2Shizuoka Univ)
2Pos176 平面型人工脂質二分子膜への昆虫細胞由来出芽ウイルスの融合観察
Observation of fusion between baculovirus budded virus envelopes and artificial planar bilayer
lipid membrane
Azusa Oshima1, Nahoko Kasai1, Hiroshi Nakashima1, Kanta Tsumoto2, Koji Sumitomo3 (1NTT Basic Res.
Labs., 2Mie Univ., 3Univ. Hyogo)
2Pos177 赤外レーザー照射によるリポソームの形態変化
Morphological changes of liposomes by infrared laser irradiation
Tomoyuki Kaneko, Akira Oguri, Shunsuke Shiomi, Mai Hayakawa, Masahito Hayashi (LaRC, FB, Hosei
Univ.)
2Pos178 抗菌ペプチド・マガイニン 2 が誘起するポア形成に対する膜電位の効果
Effect of membrane potential on antimicrobial peptide magainin 2 (mag)-induced pore formationin lipid bilayers
Md. Mamun Or Rashid1, Md. Mizanur Moghal1, Moynul Hasan1, Masahito Yamazaki1,2,3 (1Grad. Sch.
Sci. Tech., Shizuoka Univ., 2Res. Inst. Ele., Shizuoka Univ., 3Grad. Sch. Sci., Shizuoka Univ.)– S140 –2Pos179

2Pos180

2Pos1812Pos182
2Pos183

2Pos184

2Pos185

蛍光プローブでラベルされていない細胞透過ペプチド・トランスポータン 10 と単一巨大リポソー
ムとの相互作用Interaction of non-fluorescent probe-labelled cell-penetrating peptide transportan 10 with single
giant unilamellar vesicles (GUVs)
Madhabi Shuma1, Md. Mizanur Moghal1, Masahito Yamazaki1,2,3 (1Grad. Sch. Sci. Tech., Shizuoka Univ.,
2Res. Inst. Ele., Shizuoka Univ., 3Grad. Sch. Sci., Shizuoka Univ.)
浸透圧により DOPG/DOPC-GUV に誘起される膜張力の評価
Estimation of Membrane Tension of DOPG/DOPC-GUVs Induced by Osmotic Pressure
Samiron Kumar Saha1, Sayed Ul Alam Shibly1, Masahito Yamazaki1,2,3 (1Grad. Sch. Sci. Tech., Shizuoka
Univ, 2Res. Inst. Ele., Shizuoka Univ., 3Grad. Sch. Sci., Shizuoka Univ.)
抗菌性オリゴ糖が誘発する脂質二分子膜の多層化
An antibacterial oligosaccharide makes lipid bilayer multi-layered
Ayumi Sumino1,2, Tatsuya Hagiwara3, Hatsuo Yamamura3 (1WPI-NanoLSI, Kanazawa Univ., 2InFiniti,
Kanazawa Univ., 3Grad. Sch. Eng., Nagoya Inst. Tech.)
Leaflet-specific lipid diffusions in supported lipid bilayers
Takuhiro Otosu, Shoichi Yamaguchi (Saitama Univ.)
インクジェット塗布を用いたパターン化人工生体膜の開発
Inkjet-printed and dried lipid membrane arrays for the biophysical studies and biosensing
applications
Yasushi Tanimoto1, Misato Yamada2, Fumio Hayashi3, Kenichi Morigaki1,2 (1Biosignal, Kobe Univ.,
2Grad. Sch. Agr., Univ. Kobe, 3Grad. Sch. Sci., Univ. Kobe)
Multiscale molecular dynamics simulations of F-BAR protein Pacsin1: Assembly and curvature
preference on lipid membrane
Md. Iqbal Mahmood1, Hiroshi Noguchi2, Kei-ichi Okazaki1 (1Institute for Molecular Science, Okazaki,
2Institute for Solid State Physics, University of Tokyo, Kashiwa, Chiba)
高速 AFM によるハブ毒液由来のホスホリパーゼ A2 によって引き起こされる膜分解の動態観察
Membrane degradation dynamics by phospholipase A2 from snake venom observed by highspeed AFM
Magoto Kamiya1, Naoko Oda-Ueda2, Ayumi Sumino3,4 (1Division of Mathematical and Physical Sciences,
Graduate School of Natural Science and Technology, Kanazawa University, 2Department ofPharmaceutical Sciences, Sojo University, 3WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa
University, 4Institute for Frontier Science Initiative, Kanazawa University)
神経回路・脳の情報処理／Neuronal circuit & Information processing

2Pos186

2Pos187

2Pos188

グラフニューラルネットワークを用いた運動想起時脳波分類
Classification of Motor Imagery Using Graph Neural Networks
Ryo Nakajima1, Hideo Mukai2 (1Comp. Sci. Prog., Grad. Sch. Sci. & Tech., Meiji Univ., 2Dept. Comp.
Sci., Sch. Sci. & Tech., Meiji Univ.)
運動想起時脳波の時間周波数解析とニューラルネットワークによる識別Time-Frequency and neural network analysis for classification motor imagery EEG
Azumi Ohno1, Hideo Mukai1,2 (1Comp. Sci. Prog., Grad. Sch. Sci. & Tech., Meiji Univ., 2Dept. Comp. Sci.,
Sch. Sci. & Tech., Meiji Univ.)
深層畳み込みニューラルネットワークを用いたマウスの社会的行動の自動検出
Automated detection of social behavior in mice using deep convolutional neural network
Hideo Mukai1,2, Kenji Takemoto1 (1Comp. Sci. Prog., Grad. Sch. Sci. & Tech., Meiji Univ., 2Dept. Comp.
Sci., Sch. Sci. & Tech., Meiji Univ.)– S141 –2Pos189

2Pos190

2Pos191

仮想空間を用いた EEG による運動想起フィードバック訓練システムの構築
EEG-Based motor imagery feedback training system on VR environment
Hideo Mukai1,2, Kazuki Kobayashi1 (1Comp. Sci. Prog., Grad. Sch. Sci. & Tech.,Meiji Univ., 2Dept.
Comp.Sci., Sch. Sci & Tech., Meiji Univ)
線虫 C.elegans の学習行動を制御する神経回路のシナプス可塑性
Mechanisms of Synaptic Plasticity in a Neural Circuit that Regulates Memory Dependent
Behavior in C. elegans
Llian Mabardi, Hirofumi Kunitomo, Hirofumi Sato, Yu Toyoshima, Yuichi Iino (Tokyo University School
fo Science Department of Biology)
海馬で合成される男性・女性ホルモンやストレスホルモンによる記憶シナプスの早い non-genomic
な制御
Rapid non-genomic modulation of synapses by hippocampus-synthesized androgen, estrogenand stress steroid
Suguru Kawato1,2, Mika Soma1, Mari Ogiue-Ikeda1 (1Dep. Cognitive Neuroscience, Fac. Pharma-Science,
Teikyo Univ., 2Dep. Urology, Grad Sch Medicine, Juntendo Univ.)
行動／Behavior

2Pos192

A leadership-based phase transition in a flocking model with activated and un-activated agents
Sulimon Sattari1, Tamiki Komatusaki1, Mikito Toda2, Sky Nicholson3, Jason Green3, Udoy Basak1(1Hokkaido University, Research Institute for Electronic Science, 2Nara Women's University, 3University of
Massachusetts, Boston)
光生物学：視覚・光受容／Photobiology: Vision & Photoreception

2Pos193* レチナールを結合するリジンを保存しない微生物型ロドプシンの光応答性機能獲得
Engineering microbial rhodopsin without retinal-binding lysine to gain photosensitive function
Yumeka Yamauchi1, Masae Konno1,2, Daichi Yamada1,3, Kei Yura4,5,6, Keiichi Inoue1,7, Oded Béjà8,
Hideki Kandori1,2 (1Life Sci. Appl. Chem., Nagoya Inst. Tech., 2OBTRC, Nagoya Inst. Tech., 3Grad. Sch.
Life Sci., Univ. Hyogo, 4Grad. Sch. Hum. Sci., Ochanomizu Univ., 5Sim. Inf. Bio., Ochanomizu Univ., 6Sch.
Adv. Sci. Eng., Waseda Univ., 7ISSP, Univ. Tokyo, 8Technion - Israel Inst. Tech.)2Pos194* T(6-4)C の同位体標識を用いた(6-4)光回復酵素の低温における DNA 修復中間体の赤外分光測定
Low-temperature FTIR study of the repair intermediates of T(6-4)C/photolyase using isotope
labeling
Katsuya Maeda1, Mai Kumagai1, Daichi Yamada2, Yuma Terai3, Junpei Yamamoto3, Hideki Kandori1(1Nagoya Inst. Tech, 2Univ. Hyogo., 3Osaka Univ.)
2Pos195* シネコシスティスハロロドプシン（SyHR）のアニオン輸送における 塩基性アミノ酸の機能的役割
Functional roles of basic amino acids on the anion transport in Synechocystis halorhodopsin(SyHR)
Masaki Nakama1, Keiichi Kojima1, Marie Kurihara1, Susumu Yoshizawa2, Yuki Sudo1 (1Grad. Sch. ofMed. Dent.& Pharm. Sci. Okayama Univ., 2AORI, UTokyo)
2Pos196* Molecular characterization of heliorhodopsin from marine giant virus light-dependently infecting
to Emiliania huxleyi
Ritsu Mizutori1, Masae Konno1,2, Keiichi Inoue1,3, Oded Beja4, Hideki Kandori1,2 (1Grad. Sch. Eng., NIT,
2OBTRC, NIT, 3ISSP, Univ. Tokyo, 4Technion-Israel Inst. Tech.)2Pos197* 分光学的手法による霊長類青感受性視物質の光反応中間体解析
Photochemical reactions of a primate blue-sensitive pigment by spectroscopic study
Shunpei Hanai1, Kota Katayama1, Takuma Sasaki1, Hiroo Imai2, Hideki Kandori1 (1Nagoya Institute ofTechnology, 2Primate Research Institute, Kyoto University)– S142 –2Pos198

2Pos199

2Pos200

2Pos201

2Pos2022Pos2032Pos204

2Pos205

2Pos206

2Pos207(2SFA-6) 微生物型ロドプシンに基づく光遺伝学ツールの探索と開発(2SFA-6) Exploration and development of microbial rhodopsin-based optogenetic tools
Keiichi Kojima, Yuki Sudo (Grad. Sch. of Med. Dent. Pharm. Sci., Okayama Univ.)
ロドプシンクラスター上におけるトランスデューシンの動的過程の高速 AFM 観察
High-speed AFM observation of the dynamic process of transducin on rhodopsin cluster
Kazuhiko Hoshikaya1, Yasushi Tanimoto2, Hayato Yamashita1, Kenichi Morigaki2,3, Fumio Hayashi4,
Masayuki Abe1 (1Graduate School of Engineering Science, Osaka University, 2Biosignal research center,
Kobe University, 3Graduate School of Agricultural Science, Kobe University, 4Graduate School of Science,
Kobe University)
網膜桿体細胞内円盤膜上での脂質-光受容タンパク質秩序形成の数理モデル
A mathematical model of pattern formation of lipid-photoreceptor proteins on disk membranesof retinal cells
Yukito Kaneshige1, Yasushi Tanimoto2, Hiraku Nishimori1, Kenichi Morigaki2, Fumio Hayashi3,
Akinori Awazu1 (1Dept. of Math. & Sci. Hiroshima Univ., 2Dept. of Agri. Kobe Univ., 3Dept. of Sci. Kobe
Univ.)
新奇チャネルロドプシン Ts_Rh3 の電気生理学的解析
Electrophysiological analysis of a novel channelrhodopsin Ts_Rh3
Rintaro Tashiro1, Kumari Sushmita2, Suneel Kateriya2, Hideki Kandori1, Satoshi Tsunoda1,3 (1Nagoya
Institute of Technology, 2Jawaharlal Nehru University, 3JST PRESTO)
リン酸化ロドプシン･アレスチン複合体は視細胞円板膜切れ込み部に集まる
Phosphorylated-rhodopsin/arrestin complex assembles to disc incisures
Fumio Hayashi1, Fuko Kueda2, Kenichi Morigaki2,3, Keiji Seno4 (1Kobe Univ, Sci, Biology, 2Kobe Univ,
Agri, 3Kobe Univ, Biosignal, 4Hamamatsu Univ Sch Med)
ボルボックスの光驚動反応における鞭毛運動の照度依存性
Light intensity dependence of adaptive photo-response of Volvox
Yukariko Komasaka, Yoshihiro Murayama (Department of Applied Physics, Tokyo University ofAgriculture and Technology)
共鳴ラマン分光法と MD + QM/MM 計算を用いたシアノバクテリオクロム発色団の脱プロトン化部
位の同定
Identification of the Deprotonated Pyrrole Nitrogen of the Bilin-Based Photoreceptor by Raman
Spectroscopy with MD+QM/MM Analysis
Risako Miyoshi1, Shinsuke Osoegawa1, Kouhei Watanabe1, Yuu Hirose2, Tomotsumi Fujisawa1,
Masahiko Ikeuchi3, Masashi Unno1 (1Dept. Chem. & Appl. Chem., Saga Univ., 2Dept. of Appl. Chem. &Life Sci., Toyohasi Univ. of Tech., 3Dept. Life Sci. (Biology), Univ. of Tokyo,)
ビリベルジン結合型シアノバクテリオクロムの遠赤／橙色光変換過程での構造変化の検出
Detection of structural change during far-red/orange reversible photoconversion of biliverdinbinding cyanobacteriaochrome
Yuka Takeda, Keiji Fushimi, Rei Narikawa (Grad. Sch. Sci., Univ. Shizuoka)
赤外分光法によって明らかになった色覚視物質とロドプシンの構造ダイナミクスの違い
Different structural dynamics between cone pigments and rhodopsin revealed by FTIR
spectroscopy
Takuma Sasaki1, Kota Katayama1, Hiroo Imai2, Hideki Kandori1 (1Grad. Sch. Eng., Nagoya Inst. Tech.,
2Primate Res. Inst., Kyoto Univ.)
An Anion Channelrhodopsin with a Naturally Super-Slow Photocycle
Takahiro Kitahara2, Hina Kurane3, Chihiro Kikuchi2, Tomoyasu Aizawa1,4, Takashi Kikukawa1,4,
Makoto Demura1,4, Takashi Tsukamoto1,4 (1Fac. Adv. Life Sci., Hokkaido Univ., 2Grad. Sch. Life Sci.,
Hokkaido Univ., 3Sch. Sci., Hokkaido Univ., 4GSS, GI-CoRE, Hokkaido Univ.)– S143 –2Pos208

2Pos209

2Pos2102Pos211

赤外分光法により明らかとなった酵素型ロドプシンの構造的特徴
Structural features of enzyme rhodopsins revealed by infrared spectroscopy
Masahito Watari1, Tatsuya Ikuta2, Haon Hutamata2, Daichi Yamada1, Wataru Shihoya2, Kazuho Yoshida1,
Yuji Hurutani1, Satoshi Tsunoda1,3, Osamu Nureki2, Hideki Kandori1 (1Life Sci. Appl. Chem., Nagoya Inst.
Tech., 2Grad. Sch. Sci., Univ. Tokyo., 3PREST, JST)
Mastigocladopsis repens halorhodopsin の Cl-ポンプ活性における His166 の重要性
Importance of His166 for Cl--pump activity of Mastigocladopsis repens halorhodopsin
Kento Iwama1, Yumi Watanabe1, Takashi Tsukamoto1,2,3, Tomoyasu Aizawa1,2,3, Makoto Demura1,2,3,
Takashi Kikukawa1,2,3 (1Grad. Sch. Life Sci., Hokkaido Univ., 2Fac. Adv. Life Sci., Hokkaido Univ., 3GSS,
GI-CoRE, Hokkaido Univ.)
時間分解フーリエ変換赤外分光法による KR2 のナトリウムおよびリチウムイオン輸送の分子機構研究
Time-resolved FTIR spectroscopy for studying molecular mechanisms of sodium and lithium ion
transportation of Krokinobacter rhodopsin 2
Sahoko Tomida1, Hideki Kandori1, Yuji Furutani1,2 (1Nagoya Inst. Tech., 2Inst. Mol. Sci.)
Rc-PYP の多量体複合体形成における K72 の役割
Functional role of a residue K72 of Rc-PYP in light dependent oligomeric complex formation
process
Yoichi Yamazaki1, Natsuki Oka1, Yugo Hayashi1, Hironari Kamikubo1,2 (1Div. Mat. Sci. NAIST,
2IMSS,KEK)
光生物学：光合成／Photobiology: Photosynthesis

2Pos2122Pos2132Pos2142Pos215

2Pos216

2Pos217

FTIR study on the localization of the excited triplet state of chlorophyll in photosystem II
Taichi Hayase1, Yuichiro Shimada1, Ryo Nagao1,2, Takumi Noguchi1 (1Grad. Sch. Sci., Nagoya Univ.,
2RIIS, Okayama Univ.)
緑色イオウ細菌 Chlorobaculum tepidum からの反応中心複合体標品の改良
Improved preparation of the reaction center complex from the green sulfur bacterium
Chlorobaculum tepidum
Koki Wada1, Chihiro Azai2, Tetsuko Nakaniwa3, Genji Kurisu3, Hirozo Oh-oka1 (1Grad. Sch. Sci., Osaka
Univ., 2Coll. Life Sci., Ritsumeikan Univ., 3Inst. Protein Res., Osaka Univ.)
Carotenoid glycoside quenches bacteriochlorophyll a fluorescence in the photosynthetic
reaction center complex of green sulfur bacteria
Chihiro Azai1, Jiro Harada2, Takumi Inoue1, Shogo Fujimoto3, Shinji Masuda4, Daisuke Kosumi3,5 (1Col.
Life Sci., Ritsumeikan Univ., 2Dept. Med. Biochem., Kurume Univ. Sch. Med., 3Grad. Sch. Sci. & Tech.,
Kumamoto Univ., 4Cent. Biol. Res. & Info., Tokyo Inst. Tech., 5IPPS, Kumamoto Univ.)
Isolation of the Rieske/cytochrome b complex from green sulfur bacteria and interaction of the
Rieske protein with cytochrome c-556
Hiraku Kishimoto1, Takahiro Nagaoka1, Chihiro Azai2, Risa Mutoh3, Hideaki Tanaka4, Yohei Miyanoiri4,
Genji Kurisu4, Hirozou Oh-oka1 (1Grad. Sch. Sci., Osaka Univ., 2Col. Life Sci. Ritsumeikan Univ., 3Fac.
Sci., Fukuoka Univ., 4Inst. Protein Res., Osaka Univ.)
Spectroscopic characterization of a bacteriochlorophyll b-based LH1-RC complexes fromthermophilic purple bacterium Blactochloris tepida
Yukihiro Kimura1, Ryuta Seto1, Tomoaki Kawakami2, Rikako Kishi1, Michie Imanishi1,
Shinichi Takaichi3, Shinji Takenaka1, Michael T. Madigan4, Seiu Otomo2 (1Grad. Sch. Agri. Sci., Kobe
Univ., 2Ibaraki Univ., 3Tolyo Univ. of Agri., 4Southern Illinois Univ.)
光感受性アデニル酸シクラーゼ OaPAC の活性制御部位の同定
Identification of the activity-regulating site in the photoactivated adenylate cyclase (OaPAC)
Minako Hirano1, Tomoya Ishido2, Masumi Takebe3, Toru Ide2, Shigeru Matsunaga3 (1Grad. Sch. Creation
Photon Indust., 2Okayama Univ., 3Hamamatsu Photonics K.K.)– S144 –2Pos218
2Pos219

2Pos220

2Pos2212Pos222

2Pos223

2Pos224

Light-dependent structural states of OaPAC
Tomoya Ishido1, Toru Ide1, Minako Hirano2 (1Okayama University, 2GPI)
タイプ 1 ロドプシンの L/Q スイッチがヘリオロドプシンの波長制御に及ぼす影響
Effects of the L/Q switch on color tuning of heliorhodopsin
Yuta Nakajima, Hideki Kandori (Grad. Sch. Eng., NIT)
クリプト藻由来のカチオンチャネルロドプシン Gt_CCR4 のオプトジェネティクスに向けた電気生
理学的研究
Study of cation channelrhodopsin Gt_CCR4 from cryptophyte for optogenetics
Shunta Shigemura1, Shoko Hososhima1, Hideki Kandori1, Satoshi Tsunoda1,2 (1Grad. Sch. Eng., NIT, 2JST
PRESTO)
中赤外レーザーの神経系培養細胞のカルシウム濃度および膜電位への影響
The influence of mid-infrared laser on Ca2+ concentration and membrane potential of neuronlike cells
Yoshiyuki Shimizu, Toyohiko Yamauchi, Tatsuo Dougakiuchi, Gen Takebe (Hamamatsu Photonics K.K.)
中赤外光照射による細胞のアポトーシスシグナル誘導Induction of intracellular apoptotic cell signaling by mid-infrared laser exposure
Gen Takebe, Yoshiyuki Shimizu, Toyohiko Yamauchi, Tatsuo Dougakiuchi (Hamamatsu Photonics K.K.
Central Research Laboratory)
生体エネルギーを浪費する光駆動内向きプロトンポンプロドプシンの電気生理学研究と光遺伝学への応用
Electrophysiological study and optogenetics application of inward-directed proton-pumping
rhodopsin, NsXeR
Satoshi Tsunoda1,2, Shoko Hososhima1, Hideki Kandori1 (1Nagoya Institue of Technology, 2JST PRESTO)
Photo-regulate small GTPase Ras using photochromic peptide inhibitor
Nobuyuki Nishibe1, Kenichi Taii1, Toshio Nagashima2, Toshio Yamazaki2, Kazunori Kondoh1,
Shinsaku Maruta1 (1Depertment of Bioinformatics, Soka University Graduate School of Engineering,
Hachioji, Japan, 2Center for Life Science Technologies, RIKEN, Yokohama, Japan)
放射線生物：活性酸素／Radiobiology & Active oxygen

2Pos225

2Pos226

2Pos227

2Pos228

プリオンペプチド銅錯体のレドックスポテンシャル
Redox potential of copper-binding prion peptide
Shuhei Murakami, Wakako Hiraoka (Grad.Sch.of Sci.& Tech.,Meiji Univ)
低酸素下での X 線誘発 DSB の修復効率
Rejoining efficiency of X-ray-induced DSBs in hypoxia
Ryoichi Hirayama, Akiko Uzawa, Yoshiya Furusawa, Sumitaka Hasegawa (NIRS, QST)
低線量放射線に曝露された細胞の運命決定における ATM を介した細胞質の放射線応答重要性
Importance of ATM-mediated cytoplasmic radiation response in determining the fate of cells
exposed to low-dose radiation
Munetoshi Maeda1, Hideki Matsumoto2, Masanori Tomita3 (1Proton Medic. Res. Div., R&D Dept., WERC,
2Dept. Exp. Radiol. Health Phys., Sch. Med. Sci., Univ. Fukui, 3Radiat. Safety Res. Center, NTRL, CRIEPI)
酸化ストレスが引き起こす HeLa 細胞ミトコンドリア電子伝達系の機能増幅
Oxidative stress-induced enhancement of mitochondrial electron transport chain in HeLa cells
Wakako Hiraoka, Shuhei Murakami (Department of Physics, Meiji University)– S145 –生命の起源・進化／Origin of life & Evolution
2Pos229* DNA を自発的に取り込んだ細胞サイズ液滴
Aqueous polymer solutions create stable cell-sized sphere entrapping DNA: A novel scenario ofde novo cell
Fumika Fujita1, Hiroki Sakuta1, Kanta Tsumoto2, Takahiro Kenmotsu1, Kenichi Yoshikawa1 (1Facul. Life
Med. Sci., Doshisha Univ., 2Facul. Eng., Mie Univ.)
2Pos230* 遺伝子破壊変異の頻度が調節可能な系の構築およびそのゲノム縮小の進化実験への応用
Construction of a Genetic Tool for Tuning Gene-Inactivating Mutations and its Application toExperimental Evolution of Genome Reduction
Yuki Kanai1, Saburo Tsuru2, Chikara Furusawa2,3 (1Grad. Sch. Sci., Univ. Tokyo, 2UBI, Univ. Tokyo,
3BDR, RIKEN)
2Pos231 Membraneless Polyester Microdroplets as Primordial Compartments at the Origins of Life
Tony Z Jia1, Kuhan Chandru1, Yayoi Hongo1, Rehana Afrin1, Tomohiro Usui1, Kunihiro Myojo2,
Po-Hsiang Wang1, H. James Cleaves1 (1Earth-Life Science Institute, Tokyo Institute of Technology, 2Tokyo
Institute of Technology Department of Earth and Planetary Science)
2Pos232 情報高分子と連携したベシクルの自己生産
Reproduction of Vesicles coupled with Template Polymerization
Minoru Kurisu1, Harutaka Aoki1, Takehiro Jimbo1, Yuka Sakuma1, Masayuki Imai1, Sandra Luginbuhl2,
Peter Walde2 (1Grad. Sch. Sci., Univ. Tohoku, 2dep. Material, ETH)
2Pos233 Laboratory evolution of Escherichia coli reveals constrained evolutionary states for antibiotic
resistance
Junichiro Iwasawa1, Tomoya Maeda2, Takaaki Horinouchi2, Chikara Furusawa1,2,3 (1Dept. of Physics,
Univ. of Tokyo, 2RIKEN BDR, 3UBI, Univ. of Tokyo)
2Pos234 Fitness landscape of antibiotic-resistance evolution
Masayoshi Hiranaka1, Nen Saito2, Chikara Furusawa2,3 (1Grad. Sch. Sci., Univ. Tokyo, 2UBI, Univ. Tokyo,
3BDR, RIKEN)
2Pos235 Relationship between fluctuation of single-enzyme activity and evolvability
Hiroshi Ueno1, Morito Sakuma1, Yoshihiro Minagawa1, Kazuhito Tabata1, Kentaro Miyazaki2,3,
Hiroyuki Noji1 (1Dept. Appl. Chem., Grad. Sch. Eng., Univ. Tokyo, 2AIST, 3Grad. Sch. Front. Sci., Univ.
Tokyo)
ゲノム生物学／Genome biology
2Pos236

2Pos237

数理モデルとライブイメージングデータを用いた分裂酵母間期核内構造の解析
Analysis of fission yeast interphase intranuclear structure by mathematical model and live
imaging data
Yuki Takayama1, Hisamichi Senda2, Koki Ito3, Hiraku Nishimori3, Masaru Ueno3, Akinori Awazu3(1Grad. Sch. Sci., Univ. Hiroshima, 2Grad. Sch. Advanced Sciences of Matter, Univ. Hiroshima, 3Grad. Sch.
Integrated Sciences for Life, Univ. Hiroshima)
Dynamical chromatin organization during transcription
Ashwin S. Selvarajan1, Kayo Hibino2, Yuji Itoh2, Kazuhiro Maeshima1,2, Masaki Sasai2 (1Dept of Applied
Physics, Nagoya University, Nagoya, Japan, 2Structural Biology Center, National Institute of Genetics,
Mishima, Shizuoka, Japan)– S146 –生命情報科学／Bioinformatics
2Pos238

2Pos239

2Pos240

2Pos2412Pos242

機械学習を用いたタンパク質部分配列の構造及び機能の解析
Analysis of structural and functional propensities for subsequences of proteins by using
machine learning
Ryohei Kondo1, Kota Kasahara2, Takuya Takahashi2 (1Grad. Sch. Life Sci., Ritsumeikan Univ., 2Coll. Life
Sci., Ritsumeikan Univ.)
GPCR ー G タンパク質の結合選択性に関わる部位同定および結合 G タンパク種予測への応用
Determination of key regions relating GPCR-Gprotein coupling selectivity and their application
for predicting coupling G-protein kinds
Mayu Kawamura1, Risako Kasado1, Tomomi Manaka1, Ryuuji Shinozaki1,2, Masami Ikeda3,
Makiko Suwa1,2 (1Aoyamagakuin Univ. College of Sci. and Eng., 2Aoyamagakuin Univ. Grad. School. Sci.
and Eng., 3AIST AIRC)
デノボデザインによる新規 αβ 型蛋⽩質フォールドの探査
Exploration of novel alpha-beta protein folds by de novo design
Shintaro Minami1, Rie Koga1, George Chikenji2, Toshihiko Sugiki3, Naohiro Kobayashi4,
Nobuyasu Koga1 (1NINS, ExCELLS, 2Grad. Shc. of Eng., Nagoya Univ., 3Inst. for Prot. Res., Osaka Univ.,
4RIKEN, RSC)
アンサンブルドッキングによるタンパク質の相互作用面の解析
Analysis of protein interaction surfaces using ensemble rigid-body docking process
Nobuyuki Uchikoga1, Yuri Matsuzaki2 (1Dept. of Network Design, Sch. of Interdiscip. Math. Sci., Meiji
Univ., 2ToTAL, TITech)
転写因子 Med26 における天然変性蛋⽩質認識メカニズムの分子動力学的検討
Molecular dynamics study for elucidation of recognition mechanism of intrinsically disordered
proteins by transcription factor Med26
Satoshi Goto1, Takuya Takahashi2, Kouta Kasahara3 (1Coll Life Sci., Ritsumeikan Univ, 2Prof.
Univ.Ritsumei, 3Ass.Prof. Univ.Ritsumei)
数理生物学／Mathematical biology

2Pos243* (2SCP-6) 上皮メカノケミカル動態の同定(2SCP-6) System identification of mechano-chemical epithelial sheet dynamics
Yoshifumi Asakura1, Yohei Kondo2, Kazuhiro Aoki2, Naoki Honda1 (1Grad. Sch. Biostudies, Univ. Kyoto,
2Div. Quantitative Biol. ExCELLS, NIBB.)
2Pos244* 細胞周期の不均一性に関する網羅的数理モデルの構築
A comprehensive model of heterogeneous cell cycle responses
Hiroaki Imoto, Kyouichi Ebata, Shigeyuki Magi, Suxiang Zhang, Mariko Okada (IPR, Osaka Univ.)
2Pos245* 真性粘菌変形体の走磁性とその探索行動への寄与
Magnetotaxis of Physarum plasmodium and its contribution to exploration
Michinori Muro, Hiroshi Sato, Tomohiro Shirakawa (Natl Def Acad Japan)
2Pos246 (2SHP-5) 細胞内のインスリン様成長因子-I（IGF-I）シグナルは振動する(2SHP-5) Cellular insulin-like growth factor-I (IGF-I) signal can be oscillated
Masato Masuda, Fumihiko Hakuno, Shin-Ichiro Takahashi (Dep. App. Ani. Sci., Grad. Sch. Agr. Lif. Sci.,
The Univ. Tokyo)
2Pos247 BOID における第 4 のルール：他個体への注目は一定時間毎に一定の確率で失われる
The fourth rule of BOID: attention to the other individuals is lost with fixed probability every fixedtime
Tomohiro Shirakawa, Hiroshi Sato, Takuya Matsuo (Natl. Def. Acad. Japan)– S147 –2Pos248

2Pos249

2Pos250

An Information-theoretic approach toward identifying the leader(s) and aggregation place inDictyostelium Discoideum colony
Udoy Sankar Basak1, Sulimon Sattari1, Kazuki Horikawa2, Tamiki Komatsuzaki1 (1Hokkaido University,
2Tokushima University)
細胞内共生進化への理論的アプローチ
Theoretical approach to evolution of intracellular symbiosis
Sakura Aoki, Kunihiko Kaneko (The University of Tokyo Graduate School of Arts and Scienses)
Asymptotic expansion of a stochastic FitzHugh-Nagumo model
Takanobu Yamanobe (Sch. Med., Hokkaido Univ.)
非平衡・発生リズム／Nonequilibrium state & Biological rhythm

2Pos251

2Pos252

2Pos253

2Pos254

2Pos255

光応答性を持った C. elegans の集団運動
Collective motion of optically susceptible C. elegans
Ken Nagai1, Hiroshi Ito2, Takuma Sugi3 (1JAIST, 2Kyushu Univ., 3Shiga Univ. Med. Sci.)
逆ミセルを用いたフレーリッヒ凝縮の研究 (I)Studies of Frohlich condensation using reverse micelles. I
Hiroshi Murakami (QST)
孤立した粒子の運動解析を基とした、回転する自走粒子の集団運動を表す数理モデルの推定
Estimation of mathematical model representing collective motion of rotating self-propelled
particle
Tadashi Sakaguchi1, Kazuhiro Oiwa2, Hitoshi Sakakibara2, Ken Nagai1 (1JAIST, 2NICT)
抗原識別における確率的ノイズの役割
A role of stochastic noise in ligand discrimination
Masashi K. Kajita, Kazuyuki Aihara, Tetsuya J. Kobayashi (IIS, University of Tokyo)
Theoretical model of dynamics of epithelial tissue with cellular chirality
Takaki Yamamoto1, Tetsuya Hiraiwa2, Tatsuo Shibata1 (1RIKEN BDR, 2Mechanobiology Institute,
National University of Singapore)
計測／Measurements

2Pos256* 細胞内温度場は高分子に依存するIntracellular temperature field depends on polymers
Masaharu Takarada1, Kohki Okabe1,2, Takashi Funatsu1 (1Grad. Sch. of Pharm. Sci., The Univ of Tokyo,
2PRESTO, JST)
2Pos257* インフルエンザウイルス多様性解析に向けた、多次元デジタル計測技術の開発
Multi-Dimensional (MD) digital assay for analysis of influenza virus heterogeneity
Shingo Honda1, Yoshihiro Minagawa2, Kazuhito V. Tabata2, Hiroyuki Noji2 (1Dept. Bioeng., Grad. Sch.
Eng., Univ. Tokyo, 2Dept. Appl. Chem., Grad. Sch. Eng., Univ. Tokyo)
2Pos258* Development of a method for quantitative profiling of microRNAs in single exosomes
Cinya Chung, Ryo Iizuka, Takashi Funatsu (Grad. Sch. of Pharm. Sci., The Univ. of Tokyo)
2Pos259* 光ファイバーを用いた蛍光相関分光法の開発とエクソソーム研究への応用
Development of optical fiber based fluorescence correlation spectroscopy and application to
exosome study
Misato Osaka1, Johtaro Yamamoto2,3, Masataka Kinjo3 (1Grad. Sch. of Life Sci., Hokkaido Univ., 2Biomed.
Res. Inst., AIST., 3Fac. of Adv. Life Sci., Hokkaido Univ.)
2Pos260* 細胞内温度変動に関与する分子のスクリーニング法の開発
Development of a method to screen molecules related to intracellular temperature variation
Takashi Mitsubori1, Kohki Okabe1,2, Fumi Kano3, Takashi Funatsu1 (1Grad. Sch. of Pharm. Sci., The
Univ. of Tokyo, 2PRESTO, JST, 3IIR, Tokyo Inst. of Tech.)– S148 –2Pos261

2Pos262

2Pos263

Optical tweezers with red laser for new applications
Tomohiro Masuda, Wataru Nakashima, Kazuki Nakajima, Shin Yamaguchi, Takashi Sagawa,Yuichi Inoue (SIGMAKOKI CO., LTD.)
赤外超解像顕微鏡によるガチョウおよびペンギン羽毛の内部構造観察
Orientation-sensitive molecular imaging of keratin proteins of goose and penguin feathers by an
IR super-resolution micro-spectroscopy
Hirona Takahashi, Koki Kimura, Makoto Sakai (Faculty of Science, Okayama University of Science)
ミクロゲルの粘弾性特性の測定
Viscoelastic measurement of a biopolymer microgel by microcapillary aspiration
Atsushi Sakai1,2, Yoshihiro Murayama1, Miho Yanagisawa2 (1Tokyo Univ. of Agri. & Technol., 2Komaba
Inst. Sci., The Univ. Tokyo.)
バイオイメージング／Bioimaging

2Pos264* 高速イオン伝導顕微鏡による表面電荷のマッピング
Mapping of surface charge by high speed ion conductance microscopy
Shusei Kaihatsu1, Kazuki Shigyo2, Toshio Ando2, Shinji Watanabe2 (1Grad. Sch. Math. & Phys.,
Kanazawa Univ., 2WPI-NanoLSI, Kanazawa Univ.)
2Pos265* マニピュレーター付き高速 AFM スキャナーの改良
Improvement of high-speed AFM scanner with manipulator
Jun Takano1, Shun Aoki2, Kazuki Shigyo3, Shinji Watanabe3, Toshio Ando3,4, Noriyuki Kodera3,4 (1Grad.
Sch. Math. & Phys., Kanazawa Univ., 2Sch. Math. & Phys., Kanazawa Univ., 3WPI-NanoLSI, Kanazawa
Univ., 4CREST, JST)
2Pos266* タンパク質オリゴマー分布イメージング：生細胞内で空間的に不均一なオリゴマーの分布可視化に向けてProtein Oligomer Imaging: towards Visualization of Spatially Heterogeneous Oligomer
Distribution in Living Cell
Ryosuke Fukushima1, Johtaro Yamamoto2,3, Masataka Kinjo2 (1Grad. Sch. of Life Sci., Hokkaido Univ.,
2Fac. of Adv. Life Sci., Hokkaido Univ., 3Biomed. Res. Inst., AIST)
2Pos267* A ratiometric bioluminescent indicator for water hardness in living specimen
Md Nadim Hossain1,2, Ryuichi Ishida2, Mitsuru Hattori1,2, Tomoki Matsuda1,2, Takeharu Nagai1,2(1Graduate School of Engineering, Osaka University, 2ISIR, Osaka University)
2Pos268 (2SHP-4) 大気圧走査電子顕微鏡 ASEM による骨組織再構築の水中免疫電顕法と cryo-TEM 観察(2SHP-4) Observation of unstained bone tissues and immuno-EM in liquid by ASEM and cryoTEM
Chikara Sato1, Shinya Sugimoto2, Yuri Hatano1, Mari Sato1, Eiko Sakai3 (1Biomedical Res. Inst., AIST,
2Dept. Bacteriol., The Jikei Univ. Sch. Med., 3Dental Pharmacology, Nagasaki Univ.)
2Pos269 (2SEA-5) G1 期酵母細胞核内における核酸分布の XFELX 線回折イメージング(2SEA-5) Distribution of nucleic acids in yeast nucleus of G1 phase visualized by X-ray
diffraction imaging using X-ray free electron laser
Masayoshi Nakasako1,2, Takahiro Yamamoto1,2, Amane Kobayashi1,2, Mao Oide1,2, Koji Okajima1,2,
Yuki Takayama1,2,3, Tomotaka Oroguchi1,2, Masaki Yamamoto2 (1Keio University, 2RIKEN, 3University of
Hyogo Prefecture)
2Pos270 ホウレンソウグラナ膜における光化学系 II 分子間相互作用の高速 AFM による解析
HS-AFM imaging and analyses of intermolecular interaction of photosystem II in granamembrane from spinach
Daisuke Yamamoto (Fuc. Sci. Fukuoka Univ.)– S149 –2Pos271

2Pos272

2Pos273

2Pos274

2Pos275

2Pos2762Pos277

2Pos2782Pos279

2Pos280

2Pos2812Pos282

光照射でタンパク質機能阻害・細胞死を誘導する単量体光増感緑色蛍光タンパク質の開発
Monomeric green fluorescent protein based photosensitizer for photo-inducible protein
inactivation and cell death
Tomoki Matsuda1, Yemima Dani Riani1, Kiwamu Takemoto2, Takeharu Nagai1 (1ISIR, Osaka Univ.,
2Grad Sch. of Med., Yokohama City Univ.)
RNA ポリメラーゼ II により制御されるクロマチンダイナミクス
Chromatin dynamics regulated by RNA polymerase II
Yuji Itoh, Michael Babokhov, Kayo Hibino, Kazuhiro Maeshima (NIG)
電子顕微鏡トモグラフィ像への構造フィッティング
Fitting atomic structure to Electron Microscopy Tomography
Yuki Mori, Suguru Kato, Toru Niina, Shoji Takada (Kyoto University)
高輝度なポジティブ型光スイッチング蛍光タンパク質 Kohinoor 2.0 の開発
Development of a highly-bright positively reversibly photoswitchable fluorescent protein
Kohinoor 2.0 for super-resolution microscopy
Tetsuichi Wazawa1, Shusaku Uto1, Kazunori Sugiura1, Shunsuke Maeda2, Katsumasa Fujita2,
Takashi Washio1, Takeharu Nagai1 (1ISIR, Osaka Univ, 2Grad Sch of Engin, Osaka Univ)
プラズモニックナノ粒子を用いた高速マルチカラー生体 1 分子イメージング
Multi-color and high-speed imaging of single biomolecules with plasmonic nanoparticles
Jun Ando1,2, Akihiko Nakamura1,2, Mayuko Yamamoto1, Ryota Iino1,2 (1IMS, NINS, 2SOKENDAI)
Characterizing the spatio-temporal heterogeneity on biomolecular concentration, mobility andlocal environment in live cells
Sho Oasa1, Aleksandar J. Krmpot1,2, Stanko N. Nikolic1,2, Lars Terenius1, Rudolf Rigler1,3,
Vladana Vukojevic1 (1Dept. of Clin. Neurosci., Center for Mol. Med., Karolinska Inst., 2Inst. of Physics,
Univ. of Belgrade, 3Dept. of Med. Biochem. and Biophys., Karolinska Inst.)
Mapping of mechanical property on live cell surface by scanning ion conductance microscope
Satoko Kitazawa1, Linhao Sun2, Ayako Housaka2, Takahiro Watanabe-Nakayama2, Hiroki Konno2,
Mikihiro Shibata2, Shinji Watanabe2 (1Grad. Sch. Math. &Phys., Kanazawa Univ., 2WPI-NanoLSI,
Kanazawa Univ.)
定量的 ATP イメージングを用いた細胞の代謝状態の空間的相関の解析
Spatial correlation of metabolic states in mammalian cells revealed by quantitative single-cell
ATP imaging
Hideyuki Yaginuma1,2, Yasushi Okada1,3 (1BDR, Riken, 2Grad. Sch. of Eng., Univ. of Tokyo, 3Grad. Sch.
of Sci., Univ. of Tokyo)
局所特徴モーフィングした補間による深さ解像度の低い 3 次元画像の改善
Feature based local morphing improved interpolation of 3D stack images at low depth resolution
Yutaka Ueno1, Takashi Kawasaki2, Totai Mitsuyama1 (1AIST Tokyo, 2AIST Kansai)
スマートフォン発光顕微鏡による 1 細胞イメージング
Smartphone based chemiluminescence microscope for single cell imaging
Mitsuru Hattori1, Sumito Shirane2, Kuniaki Nagayama2, Takeharu Nagai1 (1ISIR, Osaka Univ., 2Life issmall. Company)
鱗翅目昆虫の変態過程における極微弱バイオフォトン発光の連続画像計測
Continuous imaging of biophoton emission of lepidopterous insects during
Shoko Usui1, Mika Tada2, Masaki Kobayashi1 (1Grad. Sch. Elec., Tohtech, 2Center for General Education.,
Tohtech)Construction of a millisecond structured illumination microscope and its application to ultrafast
super-resolution live cell imaging
Shinji Kajimoto1, Tomu Suzuki1, Narufumi Kitamura2, Mayumi Takano2, Naoko Furusawa3,
Yasushi Nakano3, Kohsuke Gonda2, Takakazu Nakabayashi1 (1Grad. Sch. Pharm. Sci., Tohoku Univ.,
2Grad. Sch. Med., Tohoku Univ., 3Konica Minolta Inc.)– S150 –バイオエンジニアリング／Bioengineering
2Pos283* DNA を用いた反応拡散系のプログラムによるハイドロゲル中におけるパターン形成
Programmable reaction-diffusion system using synthetic DNA for pattern formation in hydrogel
mediumKeita Abe, Ibuki Kawamata, Shin-ichiro Nomura M., Satoshi Murata (1Department of Robotics, Graduate
School of Engineering, Tohoku University, Japan)
2Pos284* マイクロドロップレットを用いた G タンパク質共役型受容体ペプチドアゴニスト探索法のフィジ
ビリティスタディ
Feasibility study of the method to obtain peptide agonists for G protein-coupled receptors using
water-in-oil microdropletsAnna Matsueda1, Takashi Sakurai1, Ryo Iizuka1, Yasuyuki Nakamura2,3, Jun Ishi2,3, Akihiro Kondo2,3,
Dong Hyun Yoon5, Tetsushi Sekiguchi5, Syuichi Syoji4, Soichiro Tsuda6, Takashi Funatsu1 (1Grad. Sch. of
Pharm. Sci., The Univ. of Tokyo, 2Eng. Biol. Res. Cent., Kobe Univ., 3Grad. Sch. of Sci., Technol. andInnov., Kobe Univ., 4Dept. of Nanosci. and Nanoeng., Waseda Univ., 5Res. Org. for Nano & Life Innov.,
Waseda Univ., 6On-chip Biotechnol. Co., Ltd.)2Pos285* 高分子分解酵素産生微生物の取得のための液滴の変形能を利用したスクリーニング法
Deformability-based microfluidic droplet screening to obtain microbes producing
macromolecule-degrading enzymes
Mikihisa Muta1, Kai Saito1, Ryo Iizuka1, Wataru Kawakubo2, Dong Hyun Yoon3, Tetsushi Sekiguchi3,
Shuichi Shoji3, Mei Ito4, Yuji Hatada4, Takashi Funatsu1 (1Grad. Sch. of Pharm. Sci., The Univ. of Tokyo,
2Dept. of Nanosci. and Nanoeng., Waseda Univ., 3Res. Org. for Nano & Life Innov., 4Dept. of Life Sci. andGreen Chem., Saitama Inst. of Technol.)2Pos286 カップ形状微小電極の開発と 1 細胞発現分子計測への応用
Development of cup-shaped microelectrode and its application for detection of expressedbiomolecules in single cell level
Airi Kuriyama1,2, Tomoyuki Kamata1, Dai Kato1, Naoshi Kojima1, Shohei Yamamura3, Hyonchol Kim1,2,4(1Biomed. Res. Inst., AIST, 2Grad. Sch. Eng., Tokyo Univ. Agric. Technol., 3Health Res. Inst., AIST,
4PhotoBio-OIL, AIST-Osaka Univ.)
2Pos287 太陽光に依存しない細胞内生物発光による光合成
Sunlight independent plant cell photosynthesis by self-contained bioluminescence
Kenji Osabe1, Megumi Iwano2, Ryuichi Nishihama2, Kazushi Suzuki1, Sakiko Ishida2, Tomomi Kaku1,
Takayuki Kohchi2, Takeharu Nagai1 (1Osaka Univ., I.S.I.R., 2Kyoto Univ., Grad. Sch. Biost.)
2Pos288 (2SEP-7) グラフェン電界効果トランジスタとフェムトリットルチャンバーを用いたデバイ遮蔽を超える電気的バイオセンシング(2SEP-7) Electrical Biosensing beyond the Debye Screening Length Using Graphene FieldEffect Transistor in Femtoliter Microchamber
Takao Ono1, Yasushi Kanai1, Koichi Inoue1, Yohei Watanabe2, Shin-ichi Nakakita3, Toshio Kawahara4,
Yasuo Suzuki4, Kazuhiko Matsumoto1 (1ISIR, Osaka Univ., 2Kyoto Pref. Univ of Med., 3Kagawa Univ.,
4Chubu Univ.)
3 日目（9 月 26 日（木））／Day 3（Sep. 26 Thu.）
4F 天瑞・ホワイエ／4F TENZUI・Foyer
蛋⽩質：構造／Protein: Structure
3Pos001

Dynamic docking between a flexible enzyme and its inhibitor using multicanonical MD
simulations and binding free energy calculations
Narutoshi Kamiya1, Gert-Jan Bekker2 (1Sim. Stu., Univ. Hyogo, 2IPR, Osaka Univ.)– S151 –3Pos002

3Pos003

3Pos004

3Pos005

3Pos006

3Pos007

3Pos008

3Pos009

3Pos010

3Pos011

3Pos012
3Pos013

Biological Structure Model Archive: 計算機で得られた生体分子モデルのアーカイブ
Biological Structure Model Archive: An archive for computationally obtained data
Gert-Jan Bekker, Takeshi Kawabata, Genji Kurisu (Osaka University, IPR)
Nanodisc に再構成した好熱菌由来 V-ATPase の単粒子解析
Single-particle analysis of the lipid nanodisc-reconstituted V-type ATPase/synthase from
Thermus thermophilus
Atsuko Nakanishi1, Jun-ichi Kishikawa1, Kaoru Mitsuoka2, Ken Yokoyama1 (1Faculty of Life Sci. Kyoto
Sangyo Univ., 2Res. Ctr. for UHVEM. Osaka Univ.)
Prediction of ligand distribution around a protein by 3D-RISM theory
Masataka Hamano, Masatake Sugita, Takeshi Kikuchi, Fumio Hirata (Dept. Bioinfo., Coll. Biosci.,
Ritsumeikan Univ)
アミノ酸配列情報からのフラボヘモグロビンのフォールディング機構予測
Prediction of the folding mechanism of flavohemoglobin based on average distance statitisticalmethodMaho Osugi, Takeshi Kikuchi (Dept. Bioinfo., Coll. Biosci., Ritsumeikan Univ.)
分布推定アルゴリズムによる単粒子解析投影パラメーター決定
Determination of projection parameters in single particle analysis using Estimation ofDistribution Algorithms
Nobuya Mamizu1,2, Takuo Yasunaga1 (1Kyushu Institute of Technology, 2SYSTEM IN FRONTIER INC.)
連続滴定小角 X 線散乱測定を用いた KaiC に対する KaiA の滴定挙動解析
Titration analysis of KaiA for KaiC using continuous titration small angle X-ray scattering
Risako Aoyama1, Yoichi Yamazaki1, Kento Yonezawa2, Atsushi Mukaiyama3, Yugo Hayashi1,
Sachiko Toma-Fukai1, Nobutaka Shimizu2, Shuji Akiyama3, Hironari Kamikubo1,2 (1Div. Mat. Sci., NAIST,
2IMSS, KEK, 3CIMoS, IMS)
Folding properties prediction of ribonuclease and chymotrypsin based on inter-residue average
distance statistics
K M Ahsanul Kabir, Takeshi Kikuchi (Dept. Bioinfo., Grad. Sch. of Life Sci., Ritsumeinkan Univ.,
Computational Biomolecular Chemistry lab.)
The off-axis rotor of Enterococcus hirae V-type ATPase by Volta phase contrast cryo-EM
Raymond N. Burton-Smith1, Jun Tsunoda1, Yu Yamamori2, Naoyuki Miyazaki3, Fabiana L. Imai4,
Chihong Song1, Kentaro Tomii2, Kenji Iwasaki3, Junichi Takagi5, Hiroshi Ueno7, Takeshi Murata4,
Ryota Iino6, Kazuyoshi Murata1 (1NIPS, 2AIST, 3Univ. Tsukuba, 4Chiba Univ., 5Osaka Univ., 6IMS, 7Univ.
Tokyo)
GTP 結合型および GDP 結合型微小管におけるチューブリン C 末端構造分布差の分子動力学計算による解析
Simulation study for conformational difference of tubulin C-terminal tails in GTP-bound and in
GDP-bound microtubule
Takuma Todoroki1, Yukinobu Mizuhara2, Jun Ohnuki2, Mitsunori Takano2, Koji Umezawa1,3 (1Grad. Sch.
Of Sci. & Tech., Shinshu Univ., 2Grad. Sch. of Adv. Sci. & Eng., Waseda Univ., 3IBS, Shinshu Univ.)
距離依存誘電率および溶媒接触表面積を取り込んだ SAAP 力場を用いたトリプケージの分子シミュレーション
Molecular simulation of Trp-cage using the SAAP force field with Distance-Dependent Dielectricand Solvent Accessible Surface Area
Koji Yoshida, Taku Shimosato, Michio Iwaoka (Tokai Univ., Depart. Chem.)
asymmetry of psi-loop motifs
Koki Fukuda, George Chikenji (Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.)
溶液 NMR による水素結合の直接観測
Direct observation of hydrogen bonds by solution NMR
Taiki Koizumi, Hiroki Nakajima, Yutaka Ito, Masaki Mishima (Grad. Sch. Sci., TMU)

– S152 –蛋⽩質：構造機能相関／Protein: Structure & Function
3Pos014

3Pos015

3Pos016

3Pos017

3Pos018

3Pos019

3Pos020

3Pos021

3Pos022

3Pos023

3Pos024

3Pos025(3SHA-5) STAP-2 により Breast tumor kinase が活性化する機構の解明(3SHA-5) Molecular basis of Breast tumor kinase by an adaptor protein, STAP-2
Junki Nakasako1, Yuki Matsuo2, Ryo Kanda2, Yoshino Tanaka2, Min Yao3, Tadashi Matsuda2,
Katsumi Maenaka2, Toyoyuki Ose2,3,4 (1Graduate school of Life Science, 2Faculty of Pharm., 3Faculty of
Advanced Life Science, Hokkaido University, 4JST PRESTO)
分子シミュレーションで探る angiotensin II type 1 receptor（AT1R）の活性化メカニズム
Activation mechanism of the angiotensin II type 1 receptor (AT1R) explored by molecularsimulations
Yuichiro Kanamori, Tadaomi Furuta, Minoru Sakurai (Center for Biol. Res. & Inform., Tokyo Tech)
クライオ電子顕微鏡による多剤排出ポンプ複合体 MexAB–OprM の構造解析
The wild-type structures of MexAB-OprM multidrug efflux pump revealed by cryo-electron
microscopy
Kenta Tsutsumi1, Ryo Yonehara1, Etsuko Ishizaka-Ikeda1, Naoyuki Miyazaki1,2, Shintaro Maeda1,3,
Kenji Iwasaki1,2, Atsushi Nakagawa1, Eiki Yamashita1 (1IPR, Univ. Osaka, 2TARA, Univ. Tsukuba, 3The
Scripps Research Inst.)
IgG 抗体の Fv フラグメントはドメイン運動に伴う水和構造変化によって抗原認識ループの構造変化を制御する
Domain motion of Fv-fragment in antibody immunoglobulin G controls conformation of antigenrecognizing loop through hydration structure
Tomotaka Oroguchi1,2, Masayoshi Nakasako1,2 (1Faclt. Sci. Tech., Keio Univ., 2RIKEN SPring-8 Center)
3D−RISM 理論を応用した溶液中における Met−enkephalin の構造揺らぎの解析
Analysis of structural fluctuations of Met-enkephalin in the solution phase by means of 3D-RISM
theoryMasatake Sugita1, Fumio Hirata2 (1Dept. of Bioinfo., Col. of Life Sci., Ritsumeikan Univ., 2Toyota Phys. &Chem. Res. Inst.)
網羅的構造解析による酵素機能関連天然変性蛋⽩質の探索
Exploration of disordered proteins associated with enzymatic functions by comprehensive
structural search
Satoshi Omori1, Hafumi Nishi1, Kengo Kinoshita1,2 (1GSIS, Tohoku Univ., 2ToMMo, Tohoku Univ.)
A local structural environment descriptor toward evaluating impact of rare variants in humans onprotein structures and functions
Atsushi Hijikata, Masafumi Shionyu, Tsuyoshi Shirai (Nagahama Inst. Bio-Sci. Tech.)
A new MD integration enabling large time step from accurate temperature and pressure
evaluations
Jaewoon Jung1,2, Hiraku Oshima3, Kento Kasahara3, Chigusa Kobayashi1, Takaharu Mori2, Yuji Sugita1,2,3(1RIKEN Center for Computational Science, 2RIKEN Cluster for Pioneering Research, 3RIKEN Center for
Biosystems Dynamics Research)
Protein interactions in the in vitro cyanobacterial circadian clock system revealed by SDSL-ESR
Risa Mutoh1, Takahiro Iida1, Hiroyuki Mino2, Masahiro Ishiura3 (1Faculty of Sci, Fukuoka Univ., 2Dep.
Sch. of Sci., Nagoya Univ., 3CGR, Nagoya Univ.)
Investigation of formation mechanism of Prx high molecular weight complexes
Mami Jindai1, Rino Sasaki1, Noriyuki Kodera2, Toshio Ando2, Hiroki Konno2 (1Sch. of Nat. Syst., Coll. of
Sci. & Eng., Kanazawa Univ., 2WPI Nano Life Sci. Inst. (WPI-NanoLSI), Kanazawa Univ.)
Time-localised Predictions of Conformational Transitions in Protein Dynamics
Ryuhei Harada1, Vladimir Sladek2, Yasuteru Shigeta1 (1CCS, Unv. of Tsukuba, 2Slovak Academy of
Sciences)
フレキシブルドッキングによる結合自由エネルギーと速度定数計算
Calculation of binding free energy and kinetic rates with flexible protein docking
Duy Tran, Akio Kitao (Tokodai, Grad. Life Sci. Tech.)– S153 –3Pos026
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Evolutionary diversity of Kai-protein clock system in cyanobacteria
Atsushi Mukaiyama1,2, Dongyan Ouyang1, Yoshihiko Furuike1,2, Shuji Akiyama1,2 (1IMS, 2SOKENDAI)
Hierarchical classification method of protein-protein interfaces based on their secondary
structures
Takashi Fujii, Kazuo Fujiwara, Masamichi Ikeguchi (Grad. Sch. of Eng., Soka Univ)
タンパク質ダイナミクスに対する拡散マップ法の適用
Applications of a diffusion map method to protein dynamics
Hiroto Kikuchi1, Ayori Mitsutake2, Hiroshi Fujisaki1 (1Dept. of Phys. Nippon Med. Sch., 2Dept. of Phys.
Meiji Univ.)
myPresto, computer-aided drug development software
Shinji Iida1,11, Ikuo Fukuda2, Junichi Higo2, Kota Kasahara3, Takashi Kurosawa4, Tadaaki Mashimo5,
Kiyotaka Misoo5, Yoshinori Wakabayasi6, Ryuta Murakami1,7, Chisato Kanai1,7, Yusuke Sugihara8,
Mitsuhito Wada1, Hironori Nakamura9, Yoshifumi Fukunishi10 (1NNPC, 2Grad. Sch. Sim. Hyogo Univ.,
3Col. of Life Sci., Ritsumeikan Univ., 4Hitachi Solutions East Japan, Ltd., 5IMSBIO Co., Ltd., 6BY-HEX
LLP, 7INTAGE Healthcare Inc. Drug Discovery Suport Department, 8Fujitsu Kusyu Systems Ltd.,
9Biomodeling Research Co., Ltd., 10AIST, molprof, 11JBiC)
十二量体フェリチン様 Dps の希土類バイオミラリゼーションにおける構造基盤
Structural basis of rear-earth metal biomineralization in dodecameric ferritin-like protein, Dps
Mitsuhiro Okuda1,2, Pretre Gabriela1, Kornelius Zeth3 (1CIC nanoGUNE, 2Ikerbasque, 3Roskilde
University)
演題取り消し蛋⽩質：物性・構造／Protein: Property & Structure

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天然構造が極めて類似したタンパク質の熱変性：遷移構造が異なる分子起源の理論研究
A theoretical study for thermal unfolding of proteins with quite similar native structure anddifferent transition structures
Ken Tomihara, Takashi Yoshidome (Department of Applied Physics, Tohoku University)
分子動力学法と機械学習を用いたテトラペプチドの凝集性の評価
Evaluating aggregation propensity of tetra-peptide using MD and machine learning
Yoichi Kurumida, Yutaka Saito, Tomoshi Kameda (AIRC, AIST)
Molecular evolution of the structure elements in the TIM barrel family proteins
Yasumichi Takase1, Yugo Hayashi1, Yoichi Yamazaki1, Sachiko Toma-Fukai1, Hironari Kamikubo1,2(1Div. Mat. Sci., NAIST, 2IMSS KEK)
メタノール中アラメチシンのヘリックス構造熱安定性
Thermal stability of helical conformation of alamethicin in methanol
Yoshinori Miura (Center for Advanced Instrumental Analysis, Univ. Kyushu)
ヨウ素染色を用いた種の異なるインスリンアミロイド構造の識別及びシード依存的構造伝播の追跡
Structural difference and its seed-dependent propagation of human/bovine insulin amyloid fibrils
as detected by iodine staining
Keisuke Yuzu, Eri Chatani (Grad. Sch. Sci., Kobe Univ.)
Examination of the possibility of the formation of transmissible transthyretin amyloid fibrils by
the use of proteolysis
Misato Matsumura1, Naoki Yamamoto2, Keiichi Yamaguchi3, Masatomo So3, Yuji Goto3, Eri Chatani1(1Grad. Sch. Sci., Kobe Univ., 2Fac. Med., Jichi Med. Univ., 3Inst. Protein Res., Osaka Univ.)
The mechanisms underlying the inhibition of amyloid formation by polyphenol
Yuto Kimura, Masatomo So, Yuji Goto (IPR, Osaka Univ.)– S154 –蛋⽩質：機能／Protein: Function
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In vitro assembly of metabolon by liquid-liquid phase separation
Tomoto Ura, Kentaro Shiraki (Pure and Appl.Sci.,Univ.Tsukuba)
Binding properties of heart-type Fatty-Acid-Binding Protein proved by 1,8-ANS displacement
assay
Shun Tokudome1, Mai Nomura1, Fumio Hayashi2, Shigeru Sugiyama3, Shigeru Matsuoka4,
Michio Murata5, Masashi Sonoyama1,6,7 (1Grad Sch. Sci-Tech., Univ. Gunma, 2Ctr. Inst. Analysis, Univ.
Gunma, 3Sch. Sci-Tech., Univ. Kochi, 4Grad Sch. Med., Univ. Ooita, 5Grad Sch. Sci., Univ. Osaka, 6GIAR.,
Univ. Gunma, 7GUCFW., Univ. Gunma)
混雑環境系におけるタンパク質ーリガンド結合機構の速度論的解析
Crowder effects on a protein-ligand binding process
Kento Kasahara1, Suyong Re1, Hiraku Oshima1, Isseki Yu4, Grzegorz Nawrocki5, Michael Feig5,
Yuji Sugita1,2,3 (1RIKEN BDR, 2RIKEN R-CCS, 3RIKEN CPR, 4Maebashi Inst. of Tech., 5Michigan State
Univ.)
蛋⽩質：計測・解析／Protein: Measurement & Analysis

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マニフォールドラーニングを用いた低温電子顕微鏡 4 次元イメージング法の確立に向けて
Toward constructing a four-dimensional imaging technique for cryo-electron microscopy withmanifold learning
Takashi Yoshidome (Department Applied Physics, Tohoku University)
投影方向に偏りがある低温電子顕微鏡像の全投影方向の像の回復に向けて
Toward a recovery of images from all irradiation directions using cryo-electron microscopy datawith biased irradiation directions
Ryota Kojima, Takashi Yoshidome (Department of Applied Physics, Tohoku University)
バイオ医薬品のプロセス開発および QC における MAM のためのワークフロー駆動型プラットフォー
ムソリューションA workflow driven platform solution for MAM-based critical quality attribute monitoring ofbiotherapeutics in process development and QC
Kenji Hirose1, Maki Terasaki1, Shota Nakamura1, Nilini Ranbaduge2, Henry Shion2, Ying Qing Yu2,
Min Du2, Weibin Chen2 (1Nihon Waters, 2Waters)
カチオンイオン交換と超小型飛行時間型質量分析計を用いたオンライン IEX-MS による モノクロー
ナル抗体チャージバリアントの特性解析とモニタリング
Online IEX-MS Characterization and Monitoring of mAb Charge Heterogeneity Us ing an
Optimized Cation Exchange Resin and Compact TOF MS
Maki Terasaki1, Shota Nakamura1, Kenji Hirose1, Samantha Ippoliti2, Wang Qi2, Yu Ying Qing2,
Lauber Matthew A.2 (1Nihon Waters K. K., 2Waters Corporation)
DFA イオンペア試薬、高密度フェニル結合充塡剤による ADC の高感度 LC-MS プロファイリング
High sensitivity LC-MS profiling of ADC with difluoroacetic acid ion pairing and a high coverage
phenyl-bonded stationary phase
Hiroko Iwasaki1, Kenji Hirose1, Jennifer Nguyen2,3, Jacquelynn Smith4, Olga V. Friese4, Jason C. Rouse4,
Daniel P. Walsh2, Matthew A. Lauber2 (1Nihon Waters K. K., 2Waters Corporation, 3Univ. of Copenhagen,4Biotherapeutics Pharm, Sci., Pfizer WRD)
ポリリン酸による鶏リゾチームの凝集
Polyphosphate-induced aggregation of hen lysozyme
Kenji Sasahara, Keiichi Yamaguchi, Masatomo So, Yuji Goto (IPR Osaka university)– S155 –3Pos048

超小型高分解能質量分析計の導入によるバイオ医薬品開発の課題の解決
Meeting Challenges of Implementing Accurate-Mass Mass Spectrometry for Biotherapeutic
Development in Regulated/non-Regulated Environments
Shota Nakamura1, Taiji Kawase1, Maki Terasaki1, Kenji Hirose1, Henry Shion2, Mellisa Ly2,
Nilini Ranbaduge2, Ximo Zhang2, Yun Alelyunas2, Jonathan Pugh2, Robert Lewis2, Jill Lord2,
Mark Halifax2, Nick Tomczyk2, Dale Cooper-Shepherd2, Laetitia Denbigh2, Ying Qing Yu2, Jason Rouse3,
Weibin Chen2 (1Nihon Waters K.K., 2Waters Inc., 3Pfizer Inc.)
蛋⽩質工学／Protein: Engineering

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珪藻殻への有用タンパク質提示発現による機能性材料開発
Protein display on the silica frustules of a marine diatom
Natsuki Onishi, Kensuke Nakajima, Yoshinori Tsuji, Yusuke Matsuda (Dept.Biosci., Grad.Sch.Sci.Tech.,
Kwansei Gakuin Univ.,)
Development of the engineered trimeric single-chain Fv fragment of the therapeutic antibody
Takashi Tadokoro, Kota Nakamura, Harumi Tsuboi, Katsumi Maenaka (Faculty of Pharmaceutical
Sciences, Hokkaido University)
多様なユビキチン鎖のロバストな合成法
Robust synthesis methods of various ubiquitin chains
Takumi Suzuki, Takahiro Aizu, Yutaka Ito, Masaki Mishima (Grad. Sch. Sci., TMU)
De novo design of protein structures with Ploop-motif for ATP binding
Hiroko Yamada1, Kengo Nakamura1, Takahiro Kosugi1,2,3, Nobuyasu Koga1,2,3 (1SOKENDAI, 2NINS IMS,
3NINS ExCELLS)
ヘム蛋⽩質／Heme proteins

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金属タンパク質における酸化還元電位の第一原理計算法の開発
An ab initio method of evaluating redox potential for metalloprotein
Cheng Cheng, Shigehiko Hayashi (Kyoto Univ)
ウシミトコンドリア由来酸素還元酵素の活性型の単量体構造
Monomeric structure of an active form of respiratory oxygen reductase from bovine
mitochondria
Kyoko Shinzawa-Itoh1, Takashi Sugimura2, Tomonori Misaki2, Yoshiki Tadehara1, Shogo Yamamoto1,
Makoto Hanada1, Naomine Yano1, Tetsuya Nakagawa3, Shigefumi Uene1, Takara Yamada3,
Hiroshi Aoyama4, Eiki Yamashita5, Tomitake Tsukihara1,5, Shinya Yoshikawa1, Kazumasa Muramoto1(1Graduate School of Life Science, University of Hyogo, 2Graduate School of Material Science, Universityof Hyogo, 3School of Life Science, University of Hyogo, 4Graduate School of Pharmaceutical Sciences,
Osaka University, 5Institute for Protein Research, Osaka University)
膜蛋⽩質／Membrane proteins

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脂質・コレステロール・タンパク間の協同性による上皮成長因子受容体の膜近傍ドメイン 2 量体形成機構
Lipid-cholesterol-protein interaction in the dimerization of juxtamembrane domains of epidermal
growth factor receptor
Ryo Maeda1, Yasushi Sako1, Takeshi Sato2 (1Cellular Informatics Lab., RIKEN, 2Kyoto Pharmaceutical
Univ.)– S156 –3Pos056

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バクテリオルベリン及びその前駆体の膜タンパク質ハロロドプシンへの結合特異性
Binding specificity of bacterioruberin and its precursors to membrane protein halorhodopsin
Fumiya Hattori, Takanori Sasaki (Grad.Sch.Adv.Math.Sci.,Meiji Univ)
細胞膜上 Akt の 1 分子イメージングによるシグナル伝達機構の研究
A single molecule imaging approach to understand signal transduction mechanism through Akt
on the plasma membrane
Hideaki Yoshimura, Takeaki Ozawa (Sch. Sci., Univ. Tokyo)
Triton X-100 により可溶化した Proteorhodopsin の光機能中間体の速度論的解析
Kinetic analysis of photointermediates of Proteorhodopsin solubilized with Triton X-100
Airi Yamamoto1, Fumio Hayashi2, Takashi Kikukawa3,4, Masashi Sonoyama1,5,6 (1Grad. Sch. Sci. Tech.,Gunma Univ., 2Inst. Anal. Cent., Gunma Univ., 3Fac. Adv. Life Sci., Hokkaido Univ., 4GI-CoRE, Hokkaido
Univ., 5GIAR., Gunma Univ., 6GUCFW., Gunma Univ.)
1 分子イメージングによる TRPV1 チャネル・脂質間相互作用の時空間動態解析
Spatiotemporal analysis of TRPV1 channel-lipid interaction by single molecule imaging
Yutaro Kuwashima1,2, Masataka Yanagawa2, Mitsuhiro Abe2, Yasushi Sako2, Ryohei Aoyagi1,
Makoto Arita1 (1Grad. Sch. Pharm., Univ. Keio, 2Wako Inst., Riken)
核酸結合蛋⽩質／Nucleic acid binding proteins

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The effect of the distance between the RNA sequences recognized by two RNA-binding
domains on the affinity of the MSI1-RNA interaction
Wei Hsun Tu1,2, Keisuke Kamba1, Takashi Nagata1,2, Masato Katahira1,2 (1Inst. of Adv. Energy, Kyoto
Univ., 2Grad. Sch. Energy Sci., Kyoto Univ.)
Computational insights into DNA binding affinity and its repair activity for photolyase/cryptochrome superfamily
Ryuma Sato1, Yoshiharu Mori2, Noriaki Okimoto1, Makoto Taiji1 (1RIKEN, 2Kitasato univ)
The directionality regulation mechanism of serine recombinase
Hsiu-Fang Fan (NSYSU)
Single-molecule studies of how polyamines stimulate RecA-mediated recombination
Naciye Esma Tirtom1, Yang Hsu2, Hung-Wen Li1 (1NTU, 2NTNU)
核酸／Nucleic acid

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3Pos067(3SEA-3) 温度上昇とテラヘルツ光照射は転写反応に異なる影響を及ぼす。
(3SEA-3) Terahertz radiation and temperature increase differently affect transcription by RNA
polymerase
Masahiko Imashimizu1, Masahito Tanaka1, Hiromichi Hoshina2, Koh Takeuchi1 (1AIST, 2RIKEN)
液体状 DNA の相分離を利用したドメインを持つマイクロゲルカプセルの構築
Construction of hydrogel microcapsules with domain by using phase separation of liquid-likeDNA
Yuji Nakashima, Yusuke Sato, Masahiro Takinoue (Dept. of Comp. Sci., Tokyo Tech.)
DNA 液滴を用いた液-液相分離による動的システム
Dynamic system by liquid-liquid phase separation using DNA droplet
Nozomi Tsumura, Yusuke Sato, Yuji Nakashima, Masahiro Takinoue (Tokyo Tech)
DNA 液滴ポーラスマイクロ構造の形成
Porous microstructure formation of DNA droplet
Tetsuro Sakamoto, Yusuke Sato, Masahiro Takinoue (Tokyo Institute of Technology)– S157 –3Pos068

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DNA ゲルの相転移のシミュレーションモデルと解析
Simulation model and analysis of phase transition of DNA gel
Akihiro Yamamoto, Tetsuro Sakamoto, Yusuke Sato, Masahiro Takinoue (School of Computing, Tokyo
Institute of Technology)
捩じれストレス下におけるヌクレオソーム DNA 解離および H2A/H2B2 量体脱離の自由エネルギー
プロファイルFree energy profiles of unwrapping nucleosomal DNA under torsional stress and eviction of the
H2A/H2B dimer
Hisashi Ishida, Hidetoshi Kono (Institute for Quantum Life Science, QST)
転写開始複合体における DNA 開裂に関連した DNA・タンパク質間相互作用の検討
DNA-Protein Interaction Related to DNA Opening in Transcription Initiation Complex
Genki Shino, Masahiro Shimizu, Shintaroh Kubo, Toru Niina, Shoji Takada (Dept. of Biophys., Div. of
Bio. Sci., Grad. Sch. of Sci., Univ. of Kyoto)
水・水和／電解質／Water & Hydration & Electrolyte

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Poly(N-isopropylacrylamide)のコイル-グロビュール転移に伴う水への溶解度の劇的低下の物理
Physics of drastic decrease in water solubility upon coil-to-globule transition of poly(Nisopropylacrylamide)
Masao Inoue, Tomohiko Hayashi, Simon Hikiri, Masahiro Kinoshita (Inst. Adv. Energ., Kyoto Univ.)
Water-protein interactions coupled with protein conformational transition
Soichiro Kitazawa1, Takuro Wakamoto2, Ryo Kitahara1 (1College of Pharmaceutical Sciences,
Rtisumeikan Univ., 2Graduate School of Life Sciences, Ritsumeikan Univ.)
SASA モデルにおける蛋⽩質間相互作用の過安定化
Over-stabilization of protein-protein interaction in solvent accessible surface area model
Kohei Kuroishi, Dan Parkin, Akira Yodogawa, Mitsunori Takano (Dept. of Pure & Appl. Phys., Waseda
Univ.)
Machine-learning approach for water dynamics
Taku Mizukami1, Viet Cuong Nguyen3, Hieu Chi Dam2 (1JAIST, Materials, 2JAIST, Knowledge,
3HPC.Inc)発生・分化／Development & Differentiation

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3Pos077(3SFA-7) 三次元構造モデルから発生過程における細胞機能の理解を試みる(3SFA-7) Attempt to understand the cellular function during developmental process from 3D
structural model
Junpei Kuroda1,4, Takeshi Itabashi1,2,3, Takako M. Ichinose1, Shigeru Kondo4, Atsuko H. Iwane1,2,3 (1Cell
Field Struc., BDR, Riken, 2Grad. sch. Integ. Sci. Life, Hiroshima Univ., 3Spec. Res. Promot. Group, Grad.
Sch. Fronti., Biosci., Osaka Univ., 4Pattern formation, Grad. Sch. Fronti., Biosci., Osaka Univ.)
脳形態形成におけるニューロン移動と大脳成長の連成数理モデリングA coupled mathematical modeling for neuronal migration and cerebral growth in brain
morphogenesis
Hironori Takeda1, Yoshitaka Kameo1,2,3, Taiji Adachi1,2,3 (1Grad. Sch. Eng, Kyoto Univ., 2Inst. Front. Life
Med Sci., Kyoto Univ., 3Grad. Sch. Biostudies, Kyoto Univ)
Modeling of sea urchin gastrulation based on cytoskeleton imaging
Kaichi Watanabe, Naoaki Sakamoto, Akinori Awazu (Integrated Sciences for Life in Hiroshima
University)– S158 –分子モーター／Molecular motor
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細胞分裂に関わるキネシン 5 の頭部間協調におけるネック領域の役割の高速一分子観察
High-speed single molecule studies for the role of the neck region on the head-headcoordination of mitotic kinesin-5
Taiga Yamada1, Kohei Matsuzaki2, Michio Tomishige2 (1Grad. Sch. Sci. Eng., Aoyama Gakuin Univ.,
2Dept. Math. Phys., Col. Sci. Eng., Aoyama Gakuin Univ.)
DNA ナノスプリングによる負荷を受けながら運動するキネシン 1 の高速一分子観察
High-speed single-molecule observations of kinesin-1 moving under a load from DNA origami
nanospring
Kohei Matsuzaki1, Mitsuhiro Iwaki2, Michio Tomishige1 (1Dept. Phys., Col. Sci. Eng., Aoyama Gakuin
Univ., 2BDR, Riken)
Kinetic parameters and reaction scheme of high and low activity mutants of Serratia
marcescens chitinase A
Akasit Visootsat1,2, Paul Vignon3, Akihiko Nakamura1,2, Takayuki Uchihashi4,5, Hiroki Watanabe4,5,
Ryota Iino1,2 (1IMS, 2SOKENDAI, 3ParisTECH, 4Nagoya University, 5ExCELLS)
高速原子間力顕微鏡により観察された微小管上の外腕ダイニン
High-speed atomic force microscopy on outer dynein arms aligned on microtubules
Kenta Ishibashi1,2, Kazuhiro Oiwa2,3,4 (1Osaka Univ., 2NICT-CiNet, 3Advanced ICT Research Institute,
4University of Hyogo)
Development of novel Photochromic inhibitors for kinesin Eg5 which form multiple isomerization
states utilizing azobenzene and spiropyran
Islam Md Alrazi, Kei Sadakane, Shinsaku Maruta (Department of Bioinformatics, Graduate School ofEngineering, Soka University, Hachioji, Tokyo , Japan)
回転子変異体を用いたべん毛モータースイッチ機構の解析
Analysis of the bacterial flagellar switch using mutant rotor components
Mai Kato1, Tsubasa Ishida1, Myu Yoshida2, Yoshisyuki Sowa1,2,3 (1Grad. Sch. Sci. & Eng., Hosei Univ.,,
2Dept. Frontier Biosci., Hosei Univ, 3Micro-nano Tech., Hosei Univ)
細菌べん毛モーターの回転を支える回転軸-軸受間相互作用の解析
Analysis of shaft-bearing interactions that support the smooth rotation of bacterial flagellar
motorsYumi Kumazaki1, Tsubasa Ishida1, Myu Yosida2, Yoshiyuki Sowa1,2,3 (1Grad. Sch. Sci. & Eng, Hosei
Univ., 2Dept. Frontier Biosci., Hosei Univ., 3Micro-nano Tech., Hosei Univ.)
Controlling the rotation speed of the bacterial flagellar motor with light-driven rhodopsin
So Hasegawa1, Rei Abe-Yoshizumi2, Keiichi Inoue3, Hideki Kandori2, Yoshiyuki Sowa4 (1Grad. Sch. Sci.
& Eng., Hosei Univ, 2Grad. Sch. Eng., Nagoya Inst. Tech, 3Inst. Solid State Phys., Univ. Tokyo, 4Dept.
Frontier Biosci., Hosei Univ)
Paenibacillus sp. TCA20 と大腸菌に由来するべん毛モーターキメラ固定子のイオン選択性
Ion specificity of chimeric stator proteins between Paenibacillus sp. TCA20 MotB1 andEscherichia coli MotB
Sakura Onoe1, Myu Yoshida2, Masahiro Ito3, Yoshiyuki Sowa1,2,4 (1Grad. Sch. Sci. & Eng., Hosei Univ.,
2Dept. Frontier Biosci., Hosei Univ., 3Grad. Sch. Life Sci. Toyo Univ., 4RC. Micro-nano Tech., Hosei Univ.)
DNA オリガミを用いた野生型と変異体キネシン二分子による協調運動の観察
Cooperative transport by wild-type and mutant kinesin motors as studied by using
programmable DNA origami
Shu Takano1, Ryosuke Masuda3, Kohei Matsuzaki2, Mitsuhiro Iwaki4, Michio Tomishige2 (1Grad. Sch.
Sci. Eng., Aoyama Gakuin Univ., 2Dept. Math. Phys., Col. Sci. Eng., Aoyama Gakuin Univ., 3Dept. Appl.
Phys., Grad. Sch. Eng., Univ. Tokyo, 4BDR, Riken)– S159 –3Pos088

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INHIBITION OF MITOTIC KINESIN EG5 BY KOLAFLAVANONE
Tomisin Ogunwa3, Kei Sadakane1, Ayodele O. Kolawole4, Olusola O. Elekofehinti4,
Afolabi C. Akinmoladun4, Olaposi I. Omotuyi5, Takayuki Miyanishi3, Shinsaku Maruta1,2 (1Sci. & Engin.,Soka University, 2Grad. Sch. Engin., Soka Unive., 3Grad. Sch. Fisheries and Environmental Sci, Nagasaki
Unive., 4Dept. of Biochem., The Federal Unive. of Tech., 5Centre for Biocomputing and Drug Design,
Adekunle Ajasin Unive.)
F1-ATPase の軸とシリンダーの結合寿命の測定
Single-molecule pull-out manipulation of the shaft of the rotary motor F1-ATPase
Tatsuya Naito1, Tomoko Masaike2, Daisuke Nakane1, Mitsuhiro Sugawa3, Takayuki Nishizaka1 (1Dept.
Phys., Gakushuin Univ., 2Dept. Appl. Biol. Sci., Tokyo Univ. Sci., 3Grad school of arts and sciences, Univ.
of Tokyo,)
Does giraffe kinesin move faster than mouse?
Taketoshi Kambara1, Yasushi Okada1,2 (1RIKEN BDR, 2U. of Tokyo, Grad. Sci.)
Microsecond-resolved observation of F1-ATPase conformational changes by single molecularfluorescence spectroscopy
Hiroki Senmaru1, Hiroyuki Oikawa2, Mitsuhiro Sugawa3, Satoshi Takahashi2 (1Tohoku University
Graduate school of life sciences, 2Tohoku university IMRAM, 3Tokyo university graduate school of Arts andSciences)
遺伝子工学的に人工的に設計したモータタンパク質収縮ネットワークの性能向上
Improvement of a genetically-engineered microtubule contractile protein network
Zhao Du1, Takahiro Nitta3, Yingzhe Wang2, Keisuke Morishima2, Yuichi Hiratsuka1 (1JAIST, Sch. of Mat.
Sci., 2Osaka Univ., Grad. Sch. of Eng., Dep. Mech. Eng., 3Gifu Univ., Grad. Sch. of Eng., Dep. of EECE)
暗視野顕微鏡を用いた微小管混雑時における細胞質ダイニンのステップの高時間分解能観察
Cytoplasmic dynein stepping on crowded microtubules resolved using dark-field imaging withhigh spatio-temporal resolution
Yusuke Kumagai1, Keitaro Shibata2, Ken’ya Furuta2, Hajime Honda1, Hiroaki Kojima2 (1Dep. Bioeng.,
Nagaoka Univ., 2Adv. ICT Res. Ins., NICT)
共通祖先型 F1-ATPase の一分子回転解析
Reconstruction and Characterization of Ancestral F1-ATPase
Nanako Nakama1, Hiroshi Ueno1, Ryutaro Furukawa2, Ryohei Kobayashi1, Ryo Watanabe1,
Satoshi Akanuma2, Hiroyuki Noji1 (1Dept. Appl. Chem., Grad. Sch. Eng., Univ. Tokyo, 2Facul. Human Sci.,
Univ. Waseda)
クラミドモナス軸糸ダイニン集合体の外部負荷に対する応答を測定する
Measuring mechanical responses of Chlamydomonas axonemal dynein arrays to external load
Misaki Sagawa1, Akane Furuta2, Hiroaki Kojima2, Kazuhiro Oiwa1,2, Ken’ya Furuta2 (1Grad. Sch. of Life
Science, Univ. Hyogo, 2Adv. ICT Res. Inst., NICT)
細胞生物的課題／Cell biology

3Pos096

3Pos097(3SHA-4) 過渡的に形成される GPCR ダイマーの研究：細胞内蛍光 1 分子観察によるアプローチ(3SHA-4) Examining the transiently formed GPCR dimer: an approach by single fluorescentmolecule observation in living cells
Rinshi Kasai (Inst. Front. Life. Med. Sci., Kyoto Univ.)
微小管結合蛋⽩質を介したアクチンフィラメントと微小管との束化が細胞突起に与える影響
The role of microtubule-associated protein mediated bundle formation between actin filaments
and microtubule on cell process formation
Chihiro Doki1, Masahiro Kuragano1, Kohei Nishida1, Shoma Saito1, Susumu Kotani2, Kiyotaka Tokuraku1(1Grad.Sch.Eng.,Muroran Inst.Tech., 2Fac. Sci., Kanagawa Univ)– S160 –3Pos098

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デスミンとアクチンを包含する液滴のそれらの集合により誘発される変形Deformations of droplets containing desmin and actin caused by their assembly
Yoshiya Miyasaka, Keigo Murakami, Kuniyuki Hatori (Grad. Sch. of Sci. and Eng., Yamagata Univ.)
S1P 修飾弾性率可変ゲルを用いた Muse 細胞ホーミング及び力学場応答性の解析
Homing and mechano-response of Muse cells analyzed on S1P-modified hydrogel with tunableelasticity
Lei Guo1, Yukie Tsuji2, Satoru Kidoaki2 (1Grad. Sch. Eng., Kyushu Univ., 2IMCE, Kyushu Univ.)細胞の突起形成における MAP4 の局在と機能
Localization and function of microtubule-associated protein (MAP) 4 in cell protrusion formation
Kohei Nishida1, Masahiro Kuragano1, Chihiro Doki1, Susumu Kotani2, Kiyotaka Tokuraku1 (1Grad. Sch.
Eng., Muroran Inst. Tech., 2Fac. Sci., Kanagawa Univ.)
F-actin に沿った Fimbrin の協同的クラスター形成の方向性
Direction of the cooperative cluster formation of fimbrin along actin filaments
Naoki Hosokawa1, Masahiro Kuragano1, Keitaro Shibata2, Taro Q.P. Uyeda3, Kiyotaka Tokuraku1 (1Grad.
Sch. Eng., Muroran Inst. Tech., 2NICT, 3Dep. of Physics, Fac. Sci. Engin., Waseda Univ.)
非凍結温度において氷結合タンパク質は線虫の低温耐性を改善する
Ice-Binding Proteins Improves the Survival Rate of Caenorhabditis elegans at Non-freezing
Temperature
Masahiro Kuramochi1,2,3, Geikaku Tou1, Chiaki Takanashi1, Motomichi Doi3, Kazuhiro Mio2,
Sakae Tsuda4, C. Yuji Sasaki1,2 (1University of Tokyo, 2AIST-UTokyo OIL, 3Biomedical R.I., AIST,
4Bioproduct R.I., AIST)
フェムト秒レーザー誘起衝撃力と反射干渉顕微鏡による細胞接着強度の定量評価手法の確立
Quantitative evaluation of cell adhesion strength by reflection interference contrast microscopy
combined with femtosecond laser impulse
Yukiko Yoshimura, Sohei Yamada, Yoichiroh Hosokawa, Ryohei Yasukuni, Kazunori Okano (Division ofMaterials Science, Nara Institute of Science and Technology)
アクチンネットワーク上におけるアクチン結合タンパク質の局在形成における自律的制御機構
Self-regulatory mechanisms for the segregation of actin binding proteins on actin network
Yosuke Yamazaki, Taro QP Uyeda (Dep. Phys., Waseda Univ.)
iPS 細胞は最適弾性領域に移動し、増殖促進と高質な幹細胞性保持を示す
iPS cells show mechanotactic accumulation, higher proliferation and expression of stemness
marker in optimal region of matrix elasticity
Mengfan Wang1, Satoru Kidoaki2 (1Grad. Sch. Eng., Kyushu. Univ., 2IMCE, Kyushu Univ.)
分化フラストレート MSC における APC 発現調節の上流機構の検証
Investigation of upstream regulatory factors of APC expression in the MSCs in frustrated
differentiation
Misaki Kaneshiro1, Thasaneeya Kuboki2, Satoru Kidoaki2 (1Grad. Sch. Eng., Kyushu Univ., 2IMCE,
Kyushu Univ.)
Ca2+ 存在下/非存在下における mbo1（後退運動変異株）の鞭毛波形
The flagellar waveforms of mbo1, a mutant moving backward only, in the presence/absence of
Ca2+
Hitoshi Sakakibara, Hiroaki Kojima, Kazuhiro Oiwa (Adv. ICT Res. Inst., NICT)
アクチン結合タンパク質 Rng2 がアクトミオシン in vitro 運動を協同的に阻害するメカニズム
The mechanism of cooperative inhibition of actomyosin movement in vitro by the actin binding
protein Rng2
Yuuki Hayakawa1, Yosuke Kakuta1, Ngo Kien X.2, Noriyuki Kodera2, Taro QP Uyeda1 (1Department of
Physics, Faculty of Advanced Science and Engineering, Waseda University, 2Bio-AFM Res. Ctr., Kanazawa
Univ.)– S161 –3Pos109

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二種の異なるアクチン結合タンパク質のアクチンへの結合が相互排他的かまたは協調的かを評価する観察系の構築
Establishment of observation system to evaluate whether two different actin binding proteinsbind to actin mutually or accommodative
Tenji Yumoto, Taro QP Uyeda (Dept. Physics, Waseda Univ.)
動的な誘引物質濃度勾配における好中球様 HL60 細胞の運動方向決定
Decision making of migratory direction of neutrophil-like HL60 cells in dynamical
chemoattractant gradientMotohiko Ishida1, Akihiko Nakajima2,3, Satoshi Sawai1,3 (1Dept. Basic Sci., Grad. Sch. of Arts & Sci.,
Univ. of Tokyo, Japan, 2Dept. General Systems Studies, Grad. Sch. of Arts & Sci., Univ. of Tokyo, Japan,
3Comp. Sys. Biol. Cent., Grad. Sch. of Arts & Sci., Univ. of Tokyo, Japan)
タウ–微小管相互作用の等温滴定熱測定
Isothermal titration calorimetry of tau-microtubule interaction
Junta Kashima, Hiroshi Sakamoto, Junichi Taira, Hideyuki Komatsu (Biosci. Bioinf., Kyushu Inst. Tech.)Rhodamine-phalloidin と Lifeact-GFP のアクチン結合の相互排他性
Mutual Exclusion of Actin Binding between Rhodamine-phalloidin and Lifeact-GFP
Saku Kijima2, Yuuya Aoki1, Taro QP Uyeda1 (1Dept. Physics, Waseda Univ, 2Biopro. Res. Inst., AIST)
RhPh 染色したアクチンフィラメントの 3 つの蛍光の明滅パターンの解析
Analysis of three distinct blinking patterns of RhPh fluorescence along actin filaments
Kazunori Ono, Ryuichi Kaneda, Syunsuke Ando, Koki Arai, Yosuke Yamazaki, Taro QP Uyeda (Dept.
Physics, Waseda Univ)
らせん型細菌スピロヘータの遊泳の力と速度の関係
Force-velocity relationship of the spirochete Leptospira swimming
Keigo Abe1, Kyosuke Takeba2, Shuichi Nakamura1 (1Grad.Sch.Eng., Tohoku Univ., 2Life and Env.Sci.,
Tsukuba Univ.)
生体膜・人工膜／Biological & Artificial membrane: Dynamics

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Effect of sucrose on the diffusion of proteins tethered in a glass-supported lipid bilayer
Hiromitsu Hariu (Saitama Univ.)
分子ツールとしての電位依存性ホスファターゼの改良
Improvement of voltage-sensing phosphatase as a molecular tool of phosphoinositide depletionin living cells
Akira Kawanabe1,2, Natsuki Mizutani2, Tomoko Yonezawa2, Yasushi Okamura2 (1Fac. Med., Kagawa
Univ., 2Grad. Sch. Med., Osaka Univ.)
油中水滴接触膜張力の定量的操作法とチャネル研究への応用
Manipulation and quantitative evaluation of membrane tension during single-channel current
recordings in the contact bubble bilayer
Masayuki Iwamoto1, Shigetoshi Oiki2 (1Dept. Mol. Neurosci., Univ. Fukui. Facul. Med. Sci., 2Biomed.
Imaging Res. Center, Univ. Fukui)
細菌機械受容チャネル MscL の脂質膜環境変化に対する応答のシミュレーション研究
Computational Study Focusing on the Response to Changes of Membrane Environment in
Gating of the Bacterial Mechanosensitive Channel MscL
Yasuyuki Sawada1, Ken’ichi Hashimoto2, Hisashi Kawasaki2, Masahiro Sokabe3 (1Dept. Nutrition,
Nagoya Univ. Eco., 2Biotech. Res. Ctr., Tokyo Univ., 3Mechanobiology Lab, Nagoya Univ. Grad. Sch.
Med.)
A gold nano-electrode for single channel detection
Toru Ide1,2, Minako Hirano2, Kota Kaneko1, Huimin Ma1 (1Fac. Engn. Okayama Univ., 2Photo-Bio. GPI)

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全自動パッチクランプシステムによる、アダプティブコントロールを用いた正確な 50％不活性化
状態制御実験の実現
Adaptive voltage control ensures the precise half inactivation application of voltage gatedchannels on automated patch clamp system
Kazuya Tsurudome (Sophion Bioscience K.K.)
人工イオンチャネルの分子動力学シミュレーション
All-atom molecular dynamics simulations of artificial ion channels
Takahiro Osamura1, Toru Ekimoto1, Tsutomu Yamane1, Takahiro Muraoka2, Kazushi Kinbara3,
Mitsunori Ikeguchi1,4 (1Grad. Sch. Med Life Sci., Yokohama City Univ., 2Grad. Sch. Global Innov., Tokyo
Univ. of Agri. and Tech., 3Grad. Sch. Life Sci. and Tech., Tokyo Tech, 4Med. Sci. Innov. Hub., Riken)
筋小胞体カルシウムポンプの Ca2+結合に及ぼす界面活性剤の効果
Effect of solubilization with a detergent on sarcoplasmic reticulum Ca2+-ATPase
Takashi Daiho, Stefania Danko, Kazuo Yamasaki, Satoshi Yasuda, Hiroshi Suzuki (Asahikawa Medical
Univ.)
プロトニック有機電極によるミトコンドリアの ATP 合成操作
Control of mitochondrial ATP synthesis with a protonic biotransducer
Momoka Takahashi1, Mingyin Cui2, Hiroko Kashiwagi1, Takeo Miyake2, Yoshihiro Ohta1 (1Grad. Sch.
Biotech., TUAT, 2Grad. Sch. Info., Univ. Waseda)
Toward the construction of DNA origami artificial channel with selective transport function
Shoji Iwabuchi1, Ibuki Kawamata1, Yuki Suzuki2, Satoshi Murata1, M. Shinichiro Nomura1 (1Grad. Eng.,
Univ. Tohoku, 2FRIS, Univ. Tohoku)
上皮成長因子受容体クラスターによる EGF シグナル伝達の調節
Regulation of downstream signaling by clusters of epidermal growth factor receptor
Michio Hiroshima1,2, Nario Tomishige3, Masahiro Ueda1, Toshihide Kobayashi3, Yasushi Sako2 (1RIKEN
BDR, 2RIKEN CPR, 3Univ. of Strasbourg)
p52Shc は時間依存的に Grb2 のシグナル伝達ダイナミクスを制御する
p52Shc regulates Grb2 signaling dynamics in a time dependent manner after cell stimulation
Ryo Yoshizawa1, Nobuhisa Umeki2, Masataka Yanagawa2, Masayuki Murata1, Yasushi Sako2(1Grad.sch.arts and ahi., the univ. Tokyo, 2Wako Inst., Riken)
Analysis of electrostatic interaction of acidic glycolipid with transmembrane peptide of insulin
receptor
Yuka Nimura1, Kazuya Kabayama1,2,3, Yuya Asahina4, Shinya Hanashima1, Hironobu Hojo4,
Michio Murata1, Koichi Fukase1,2,3 (1Grad. Sch. of Sci., Osaka Univ., 2MS-CORE, PRC, Grad. Sch. of Sci.,
Osaka Univ., 3Inst. for Radiation Sciences, Osaka Univ., 4Inst. for Protein Research, Osaka Univ.)
細胞膜断片ブレブを用いたモデル生体膜への膜タンパク質再構成
Direct reconstitution of membrane proteins from cell membrane blebs into a model biologicalmembrane
Rurika Nagai1, Yasushi Tanimoto2, Rinshi Kasai3, Kenichi Suzuki4,5, Fumio Hayashi6,
Kenichi Morigaki1,2 (1Grad. Sch. Agr., Univ. Kobe, 2Biosignal Research Center, Univ Kobe, 3Institute for
Frontier Life and Medical Sciences, Univ Kyoto, 4G-chain, Univ. Gifu, 5Grad of Nat. Sci and Tech., Univ
Gifu, 6Grad. Sch. Scie, Univ. Kobe)
神経回路・脳の情報処理／Neuronal circuit & Information processing

3Pos129

アガロース微細構造を用いた海馬細胞から伸長する神経突起の相互作用の解析
Interactions of neurites elongated from isolated hippocampal cells in agarose width-lengthcontrolled microchannels
Yuhei Tanaka1, Shota Aoki1, Haruki Watanabe2, Kenji Shimoda2, Akihiro Hattori3, Masao Odaka3,
Kenji Yasuda1,2,3 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure &Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda Univ.)– S163 –3Pos130

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Implementation of automated driving by deep reinforcement learning on high definition simulator
Shunsuke Isomura1, Hideo Mukai1,2 (1Comp. Sci. Prog., Grad. Sch. Sci & Tech., Meiji Univ., 2Dept. Comp.
Sci., Sch. Sci & Tech., Meiji Univ.)
単一の神経突起における伸長特性を測定するためのスポット吸収マイクロニードルを用いた µm
単位の精度のアガロース微細加工技術
Precise μm agarose microfabrication technology with spot absorption microneedle for single
neurite elongation property measurement
Haruki Watanabe1, Yuhei Tanaka2, Shota Aoki2, Kenji Simoda1, Takahito Kikuchi2, Akihiro Hattori3,4,
Masao Odaka3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ.,
2Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives,
Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore (WABIOS))
畳み込みニューラルネットワークを用いた脳波解析手法の実装
Implementation of EEG analysis method with Convolutional Neural Networks
Hiroaki Takao1, Hideo Mukai1,2 (1Comp. Sci. Prog., Grad Sch. Sci & Tech., Meiji Univ., 2Dept. Comp.
Sci., Sch. Sci. & Tech., Meiji Univ.)
光生物学：視覚・光受容／Photobiology: Vision & Photoreception

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リガンド非結合時のオプシンは稀に光活性化したロドプシンと同等の活性を示す
Apo-opsin exists in equilibrium between a predominantly inactive and a rare highly active state
Shinya Sato1,2, Beata Jastrzebska3, Andreas Engel3, Krzysztof Palczewski3,4, Vladimir J. Kefalov1 (1DOVS,
Washington Univ., 2Grad. Sch. Biostudies., Kyoto Univ., 3Case Western Reserve Univ., 4UC Irvine)
天然のバクテリアを用いたヘリオロドプシンの機能研究
Function study of heliorhodopsin using native bacteria
Ai Muto, Rei Abe-Yoshizumi, Hideki Kandori (Nagoya Inst. Tech.)
メラノプシンの光活性化機構
Photoactivation process of Melanopsin
Masami Kugo1, Takahiro Yamashita1, Yoshinori Shichida2, Yasushi Imamoto1 (1Grad. Sch. Sci., Kyoto
Univ., 2Ritsumeikan Univ.)
アミノ酸置換による脊椎動物ロドプシンのバイステーブル特性化
Construction of vertebrate rhodopsin with bistable property by a single mutation
Kazumi Sakai1, Yoshinori Shichida2, Takahiro Yamashita1 (1Graduate School of Science, Kyoto
University, 2Research Organization for Science and Technology, Ritsumeikan University)
高角 X 線散乱法による光活性化ロドプシンの活性構造安定化メカニズムの解析
Stabilization Mechanism of Active Conformation of Photoactivated Rhodopsin Studied by HighAngle X-Ray Scattering
Yasushi Imamoto1, Keiichi Kojima2, Toshihiko Oka3, Ryo Maeda4, Yoshinori Shichida5 (1Grad. Sch. Sci.,
Kyoto Univ., 2Grad. Sch. Med. Dent. Pharm. Sci., Okayama Univ., 3Grad. Sch. Sci., Shizuoka Univ.,
4RIKEN, 5Ritsumeikan Univ.)
シアノバクテリオクロム型光受容体のシステイン残基の着脱反応におけるプロトンの役割
Protochromic Absorption Changes in Two-Cys Photocycle of the Blue/Orange
Cyanobacteriochrome
Teppei Sato1,2, Takashi Kikukawa3, Risako Miyoshi4, Kosuke Kajimoto4, Chinatsu Yonekawa1,
Tomotsumi Fujisawa4, Masashi Unno4, Toshihiko Eki1, Yuu Hirose1 (1Toyohashi Univ. of Tech., 2Nagoya
Univ., 3Hokkaido Univ., 4Saga Univ.)
パターン化モデル膜を用いたロドプシンリン酸化とアレスチン結合の解析
Rhodopsin phosphorylation and arrestin binding studied in a patterned model membrane
Fuko Kueda1, Yasushi Tanimoto2, Fumio Hayashi3, Kenichi Morigaki2,4 (1Fac. Agr., Univ. Kobe,
2Biosignal Research Center, Univ. Kobe, 3Grad. Sch. Scie., Univ. Kobe, 4Grad. Sch. Agr., Univ. Kobe)– S164 –3Pos140

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長波長光感受性視物質の塩化物イオン結合における Gln114 の役割
Role of Gln114 in chloride binding of long-wavelength-sensitive visual pigment
Kota Katayama1, Shunta Nakamura1, Takuma Sasaki1, Hiroo Imai2, Hideki Kandori1 (1Grad.Sch.Eng.,
Nagoya Inst. Tech, 2Orimate Res. Inst., Kyoto Univ)
Comparative Study for Anion Transport Activity of Anion Channelrhodopsins by Using a Simple
pH Electrode Method
Chihiro Kikuchi (Grad. Sch. Life Sci.)
光生物学：光合成／Photobiology: Photosynthesis

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3Pos147(3SDA-3) 生体組織への応用が期待される光感度の高いチャネルロドプシン(3SDA-3) Novel optogenetics tool: A light-gated cation channel with high-reactivity to weak light
Shoko Hososhima1, Shunta Shigemura1, Hideki Kandori1, Satoshi Tsunoda1,2 (1Nagoya Institute ofTechnology, 2JST, PRESTO)
光依存的にホモオリゴマー化する植物クリプトクロム 2 の分子特性
Molecular properties of light-dependent homo-oligomerizing At CRY2
Kazuya Agata1, Daichi Yamada2, Hideki Kandori1 (1Nagoya Inst. Tech., Dept. Life Sci. Appl. Chem.,
2Univ. Hyogo, Dept. Life Sci.)
光ジッパーを用いた bZIP 型転写因子の標的配列認識の解析
Analyses of the target sequence recognition of a bZIP factor, using a light-activatable
Photozipper
Osamu Hisatomi, Samu Tateyama, Itsuki Kobayashi (Grad. Sch. of Sci., Osaka Univ.)
光制御型 bZIP 転写因子（フォトジッパー）の β シート疎水面の役割
Hydrophobic residues on the β-sheet of a light-activatable bZIP factor, Photozipper
Hiroto Nakajima, Itsuki Kobayashi, Osamu Hisatomi (Grad.Sch.of Sci.,Osaka Univ.)
高速 AFM による DNA 結合光受容タンパク質 Photozipper の 1 分子動態イメージング
Single molecular dynamics imaging of DNA binding photoreceptor protein, Photozipper, by
high-speed AFM
Kento Nomura1, Hayato Yamashita1, Osamu Hisatomi2, Masayuki Abe1 (1Grad. Sch. of Eng. Sci., Osaka
Univ., 2Grad. Sch. of Sci., Osaka Univ.)
Theoretical study on molecular mechanism of a light-driven ion transport of Halorhodopsin fromNatronomonas pharaonis
Ryo Oyama, Taisuke Hasegawa, Shigehiko Hayashi (Grad. Sch. Sci., Univ. Kyoto)
ゲノム生物学／Genome biology

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ウニ初期胚核内構造の発生に伴う動的変化とその細胞特異性
Dynamic and cell specific changes in intranuclear chromosomal
Yuhei Yasui (Integrated science for life, Hiroshima Univ)
ヌクレオソーム排他的ループ非形成型インスレーター配列（NENLIS）によるインスレーター活性のゲノムワイド解析
Genome-wide analysis of insulator activity by nucleosome exclusive non-looping insulator
sequence (NENLIS)
Yudai Hirose1, Yuki Matsushima1, Naoaki Sakamoto2, Akinori Awazu2 (1Grad. Sch. Sci., Univ.
Hiroshima, 2Grad. Sch. Integrated Sci., Univ. Hiroshima)
X 染色体不活性化を誘導する染色体動態
The dynamics of chromosomes that trigger X chromosome inactivation
Tetsushi Komoto, Hiraku Nishimori, Akinori Awazu (Integrated Science for Life in Hiroshima university)– S165 –生命情報科学／Bioinformatics
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Machine learning models for predicting ligand-binding sites using residue-wise features
Masafumi Shionyu, Atsushi Hijikata (Fac. Biosci., Nagahama Inst. Bio-Sci. Tech.)
モノクローナル抗体の詳細と提供情報のデータベース
Database for information of acquirable monoclonal antibody
Hirofumi Suzuki1, Mika Kaneko2, Yukinari Kato2, Kei Yura1,3 (1Dept. Life Sci. & Med. Bio., Waseda
Univ., 2Grad. Sch. of Med., Tohoku Univ., 3Sim. Info. Bio., Ochanomizu Univ.)
強力な順方向遺伝学による生物システム解析 -Vibrio alginolyticus の走性への応用
Biological system analysis by a strong forward genetics -An application to a taxis in a strain
Vibrio alginolyticus
Kunio Ihara1, Kazuma Uesaka1, Noriko Nishioka2, Seiji Kojima2, Michio Homma2 (1Nagoya University
Cent.Gene Res., 2Nagoya University Grad. School Sci.)
時点数の少ないトランスクリプトームデータからのネットワーク推定に適した遺伝子グループ化法
Gene grouping strategy for network inference from a small time-series transcriptome data
Kiyohiro Maeda (Fujifilm Corporation)
生物発光タンパク質およびルシフェリンの獲得進化解析
Evolutionary Analysis of Luciferase, Photoprotein and Luciferin
Misato Funahashi1, Hirofumi Suzuki2, Kei Yura1,2 (1Grad. Schl Hum. Sci., Ochanomizu Univ., 2Schl Adv.
Sci. Engng., Waseda Univ.)
数理生物学／Mathematical biology

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二倍体遺伝子発現制御系における集合的メンデル遺伝
Group Mendelian Dominance in Diploid Gene Regulatory Network
Kenji Okubo, Kunihiko Kaneko (Dep. of Basic Sci., Univ. Tokyo)
不正確な素子から機能的なネットワークをつくる方法
Cooperative architecture for functional network from sloppy gene expression dynamics
Masayo Inoue1, Kunihiko Kaneko2 (1IMS, Meiji Univ., 2Univ. of Tokyo)
混雑下のナノ～マイクロマシン集団：内部状態と環境の相互干渉
Nano/Micro-machines in the Crowd: Interplay between the Internal State and Surroundings
Yuichi Togashi1,2 (1RIKEN BDR, 2Grad. Sch. Integ. Sci. Life, Hiroshima Univ.)
3D phase field simulation for macropinocytosis of amoeboid cells
Nen Saito1, Satoshi Sawai2 (1Grad. Sch. Sci., Univ. Tokyo, 2Grad. Sch. Arts Sci., Univ. Tokyo)
Geometric feature extraction from some gene expression pattern for prediction of atopic
dermatitis patients
Takuya Hasebe1, Masahiro Sugimoto2, Takanori Sasaki1 (1Grad. Sch. Adv. Math. Sci., Meiji Univ.,
2RDCMIT, Tokyo Med. Univ.)増殖系と隠れマルコフモデルの対応に基づく学習の考察
A Study on Learning in Growing Population on the Basis of Hidden Markov Model
So Nakashima1, Tetsuya J. Kobayashi2 (1grad. school of IS&T, UTokyo, 2IIS, UTokyo)
脳神経系の動的ネットワークモデルにおける自発的階層構造形成
Spontaneous hierarchical structure formation in dynamic network model of cerebral nervous
systemAmika Ohara, Hiraku Nishimori, Akinori Awazu (Dept. of math. and life sci. Hiroshima univ.)
Fitness response relation of a multitype age-structured population dynamics
Yuki Sughiyama1, So Nakashima2, Tetsuya Koabayasi1 (1IIS, The University of Tokyo, 2Department ofMathematical Informatics, The University of Tokyo)– S166 –3Pos164

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Simulation and regulation of E.coli which has autonomous diversification ability
Eriko Nakagawa1, Shotaro Ayukawa2, Daisuke Kiga1 (1Department of Electrical Engineering andBioscience, Waseda University, 2Waseda Research Institute for Science and Engineering, Waseda
University)
Probability landscape of coupled epigenetic and genetic network with eddy-like probability
currents
Bhaswati Bhattacharyya, Masaki Sasai (Department of Applied Physics, Nagoya University)
ドロップアウトを適用したニューラルネットワークアルゴリズムによる大腸菌の遺伝子制御ネッ
トワークの推定Inference of gene regulatory network of E.coli by neural network algorithm applied dropout
Yusuke Mizukoshi1, Masahiro Sugimoto2, Takanori Sasaki3 (1Grad. Sch. Adv. Math. Sci., Univ.Meiji,
2RDCMIT, Univ.Tokyo Med, 3Grad. Sch. Adv. Math. Sci., Univ.Meiji)
非平衡・発生リズム／Nonequilibrium state & Biological rhythm

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Active Nematic Sperms in Vivo Mouse
Tsuyoshi Hirashima1, Kyogo Kawaguchi2, Takuya Omotehara3, Masahiro Itoh3, Kenta Ishimoto4,
Michiyuki Matsuda1,5 (1Grad Sch Med, Kyoto Univ, 2RIKEN, 3Tokyo Medical University, 4Grad Sch MathSci, The Univ of Tokyo, 5Grad Sch Biostudies, Kyoto Univ)
メチルセルロースとの相分離が誘起する重合過程アクチン線維の紡錘形液晶ドメイン自発形成
Emergence of spindle-shaped namatic domains of filamentous actin during polymerizationinduced by phase-separation from methylcellulose
Masahito Hayashi1, Tomoyuki Kaneko1, Kingo Takiguchi2 (1LaRC, Frontier Biosci., Hosei Univ., 2Dept.
Biol. Sci., Grad. Sch. Sci., Nagoya Univ.)
Traveling band formation of a mutant Dictyostelium cell population induced by contact followingof locomotion
Masayuki Hayakawa1, Tetsuya Hiraiwa2, Yuko Wada1, Hidekazu Kuwayama3, Tatsuo Shibata1 (1Riken
BDR, 2Dept. of Phys, Univ. of Tokyo, 3Faculty of Life and Env. Sci., Univ. of Tsukuba)
高速 AFM による KaiC、KaiB、SasA 間相互作用のリン酸化状態依存性観察
High-Speed AFM observation of phosphorylation state-dependent interactions between KaiC,
KaiB and SasA
Kenta Ueda1, Tetsuya Mori2, Shogo Sugiyama3, Takayuki Uchihashi1, Carl H. Johnson2 (1Dept. of Sci,
Nagoya Univ, 2UnivDept.of Biol.Sci., Vanderbilt Univ, 3Dept. of Phys, Kanazawa)
Individual cyanobacterial circadian rhythms under chilly conditions
Hiroshi Ito1, Hinako Maruayama1, Irina Mihalcescu2 (1Grad. Sch. Design., Kyushu Univ., 2LIPhy,
Universite Grenoble Alpes)
計測／Measurements

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多電極システムを用いた心毒性検査のためのハイスループットチャンバーの改良
Improvement of high-throughput chamber for cardio-toxicity testing with multi-electrode arraysystemNaoki Tadokoro, Tomoyuki Kaneko (LaRC, FB, Hosei Univ.)
HPD による広視野蛍光 1 分子偏光検出
Wide-field single-molecule fluorescence polarization detection by hybrid photo-detectors(HPDs)
Atsuhito Fukasawa1, Gaku Nakano1, Minako Hirano2, Toru Ide3, Hiroaki Yokota2 (1Hamamatsu
Photonics K.K., 2Grad. Sch. Creation Photon Indust., 3Grad. Sch. Interdisciplinary Sci. and Engineering in
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蛍光タンパク質の赤外スペクトル測定－発色団部位の選択的な観測－
IR spectra of fluorescent proteins -selective measurement of chromospheresHirona Takahashi, Makoto Sakai (faculty of Science, Okayama University of Science)
蛍光計測技術を用いた高分子クラウディングが与える相互作用の評価
Elucidation of the Effect of Macromolecular Crowding to Molecular Interactions using
Fluorescence Fluctuation Microscopy Techniques
Fusako Gan1, Akito Matsui1, Johtaro Yamamoto2, Masataka Kinjo3 (1Grad. Sch. of Life Sci., Hokkaido
Univ., 2Biomed. Res. Inst., AIST, 3Fac. of Adv. Life Sci., Hokkaido Univ.)
Examination of backtracking engulfment mechainism in macrophages using on-chip single cell
observation assay
Amane Yoshida1, Yuya Furumoto1, Toshiki Azuma1, Takahiro Kitahara2, Tomoyasu Sakaguchi2,
Masao Odaka3, Akihiro Hattori3, Kenji Yasuda1,2,3 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. &Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res.
Initiatives, Waseda Univ.)
キャピラリー吸引法を用いた単一マクロファージの一連の貪食における余分な体積増加について
Extra volume increase of single macrophage during sequential phagocytosis occurred by using
micropipette aspiration measurement assay
Toshiki Azuma1, Yuya Furumoto1, Amane Yoshida1, Masao Odaka2, Akihiro Hattori2,
Tomoyasu Sakaguchi3, Takahiro Kitahara3, Kenji Yasuda1,2,3 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv.
Sci. & Eng., Waseda Univ., 2Org. Univ. Res. Initiatives, Waseda Univ., 3Dept. Pure & Appl. Phys., Sch.
Adv. Sci. & Eng., Waseda Univ)
Releasing SecM translation arrest and observing resumed translation using magnetic tweezers
Zhuohao Yang, Ryo Iizuka, Takashi Funatsu (Grad. Sch. of Pharm. Sci., The Univ. of Tokyo)
バイオイメージング／Bioimaging

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3Pos1813Pos182(3SGA-5) 転写伸長を制御するメディエーターの 1 分子超解像イメージングによる分子局在と動態の定量解析(3SGA-5) Molecular localization and dynamics of Mediator regulating transcription elongation
using single-molecule and super-resolution microscopy
Yuma Ito1, Shinnosuke Kunimi1, Hidehisa Takahashi2, Makio Tokunaga1 (1Sch. Life Sci. Tech., Tokyo
Inst. Tech., 2Grad. Sch. Med. Life Sci., Yokohama City Univ.)
酸性細胞環境内の超解像イメージング応用に向けた耐酸性可逆的光スイッチング緑色蛍光タンパ
ク質の開発
Acid-tolerant Reversibly Switchable Green Fluorescent Protein for Super-resolution Imaging in
Acidic Conditions
Hajime Shinoda1,2, Kai Lu3, Ryosuke Nakashima3, Tetsuichi Wazawa3, Kosuke Noguchi2,
Tomoki Matsuda2,3, Takeharu Nagai2,3 (1CPR, Riken, 2Grad. Sch. Eng., Osaka Univ., 3ISIR, Osaka Univ.)
Direct observation of heterogeneous starvation response and emergence of surviving
subpopulation in the clonal microbial population
Sotaro Takano1, Miki Umetani2, Hidenori Nakaoka2, Yuichi Wakamoto2,3,4, Ryo Miyazaki1,5,6 (1AIST,
Bioprod. Inst., 2Grad. Sch. of Arts and Sci., Univ. of Tokyo, 3Universal Biol. Inst., Univ. of Tokyo, 4Res.
Center for Complex Syst. Biol., Univ. of Tokyo, 5AIST, CBBD-OIL, 6Life and Env. Sci., Univ. of Tsukuba)
ヘアレスマウスにおける皮質拡延性抑制の近赤外無侵襲測定
Noninvasive near-infrared monitoring of intrinsic optical signals caused by high K+-induced
cortical spreading depression in hairless mice
Hiro Yamato1, Takashi Jin2, Yasutomo Nomura1 (1Grad. Eng. Maebashi Inst. Tech., 2RIKEN BDR)

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1 粒子でナノスケール温度計とナノスケール熱源になる蛍光ナノダイヤモンド
Application of individual fluorescent nanodiamond as nanothermometer and nanoheater
Chongxia Zhong1, Shingo Sotoma1,2, Yoshie Harada1,3, Madoka Suzuki1 (1Institute for Protein Research(IPR), Osaka University, 2Japan Society for the Promotion of Science(JSPS), 3QIQB, OTRI, Osaka
University)
粒子フィルター MD シミュレーションによる高速 AFM データからの分子動態推定
Biomolecular dynamics inferred from high-speed AFM data via particle-filter MD simulations
Suguru Kato, Toru Niina, Sotaro Fuchigami, Shoji Takada (Kyoto University)
Elucidation of the aggregation of serum amyloid A protein and health diagnosis using a highthroughput screening system
Xuguang Lin1, Masahiro Kuragano1, Kenichi Watanabe2, Kiyotaka Tokuraku1 (1Dep. of App. Sci. andEng., Muroran Ins. of Tech., 2Obihiro Univ. of Agric. Vet. Med.)
3D time-laps imaging of alpha-synuclein aggregation using quantum-dot nanoprobes
Min Nuo1, Masahiro Kuragano1, Q.P Taro Noguchi2, Kiyotaka Tokuraku1 (1Dep. of App. Sci.and Eng.,
Muroran Ins. of Tech., 2NIT, Miyakonojo College)
Three-dimensional analysis for formation process of amyloid β42 aggregation using quantum
dots nanoprobe
Masahiro Kuragano, Kiyotaka Tokuraku (Div. of Sust. and Env. Eng., Muroran Inst. of Tech.)
高速 AFM を用いた HECT 型ユビキチンリガーゼのユビキチン化に伴う構造動態の観察
Observation of the structural dynamics associated with ubiquitination of HECT-type ubiquitin
ligase using high-speed AFM
Ikumi Mruo1, Takahiro Watanabe-Nakayama2, Toshio Ando2, Hiroki Konno2 (1Grad. Sch. of Nat. Sci. &Technol., Kanazawa Univ., 2WPI Nano Life Sci. Inst. (WPI-NanoLSI), Kanazawa Univ.)
Kinesin transport on microtubules studied by high-speed AFM
Christian Ganser1, Syeda Rubaiya Nasrin2, Akira Kakugo2,3, Ryota Iino4, Takayuki Uchihashi5(1ExCELLS, NINS, 2Grad. Sch. Chem. Sci. Eng., Hokkaido Univ., 3Fac. Sci., Hokkaido Univ., 4IMS, NINS,
5Grad. Sch. Sci., Nagoya Univ.)
鎖の細胞膜提示システムの構築とその機能解析
Construction and functional analysis of the glycan display system on the cell membrane
Ayane Miura1, Kazuya Kabayama1,2,3, Syuto Miyake1, Hiroki Syomura1, Yoshiyuki Manabe1,
Toshiyuki Yamaji4, Kentaro Hanada4, Koichi Hukase1,2,3 (1Grad. Sch. of Sci., Osaka Univ., 2MS-CORE,
PRC, Grad. Sch. of Sci., Osaka Univ., 3Inst. for Radiation Sciences, Osaka Univ., 4NIID)
分岐鎖アミノ酸に対する遺伝子コード型蛍光バイオセンサー
Genetically encoded fluorescent biosensor for branched-chain amino acids
Hiromi Imamura, Tomoki Yoshida, Hitomi Nakajima, Sena Takahashi, Akira Kakizuka (Grad. Sch.
Biost., Kyoto Univ.)
Odor-evoked responses in mouse whole brain as detected by BOLD-fMRI analyses withperiodic stimulation and independent component analysis
Mitsuhiro Takeda, Fuyu Hayashi, Naoya Yuzuriha, Sosuke Yoshinaga, Hiroaki Terasawa (Kumamoto
University, Faculty of Life Sciences)
クライオ電子線トモグラフィー法による糸状仮足中のアクチン繊維とファシンの可視化
Visualization of F-Actin with Fascin in Filopodia by electron cryo-tomography
Naoko Kajimura1, Takuo Yasunaga2, Kaoru Mitsuoka1 (1Research Center for Ultra-High Voltage EM,
Osaka Univ., 2Grad. Sch. Comp. Sci. Syst. Eng., KIT)
Fluorescent Ca2+ indicators for multiplexed super-resolution imaging at nanoscopic cellulardomainKai Lu, Tomoki Matsuda, Tetsuichi Wazawa, Takeharu Nagai (ISIR, Osaka University)– S169 –バイオエンジニアリング／Bioengineering
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Yoshihiro Sasaki, Ryosuke Mizuta, Naoya Kinoshita, Kazunari Akiyoshi (Department of Polymer
Chemistry, Graduate School of Engineering, Kyoto University)
3D image construction methods for observation of cell with micro manipulation
Masaru Kojima1, Yuma Takeuchi1, Yasushi Mae1, Tatsuo Arai2,3 (1Grad. Sch. Eng.Sci., Osaka Univ.,
2UEC, 3BIT)
Distinct morphologies of integrin-targeted peptide co-assemblies in peritumoral space vsphysiological ECM
William Cortes, Sona Roy, Sachie Yukawa, Toshio Sasaki, Wu Xia, Ye Zhang (Ye Zhang Unit, Okinawa
Institute of Science and Technology)
環状柔軟多関節 DNA モチーフの自己集合
Self-assembly of a Flexible Multi-joing Ring Motif
Shiyun Liu, Ibuki Kawamata, Shin-ichiro Nomura, Satoshi Murata (Grad. Sch. Eng., Univ. Tohoku)
オン・チップマルチイメージングフローサイトメトリーでの血中の循環腫瘍細胞の同定のための
サイズ解析
Size distribution analysis of circulating tumor cell clusters in blood using on-chip multi-imaging
flow cytometry
Masao Odaka1, Akihiro Hattori1, Kenji Yasuda1,2 (1Org. Univ. Res. Initiatives, Waseda Univ., 2Dept. Pure
& Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ.)
アミロイド凝集阻害物質の自動スクリーニングシステムにより見出した高活性天然抽出物の評価
Evaluation of highly active natural extracts found by an automated screening system for amyloid
aggregation inhibitors
Rina Sasaki1, Masahiro Kuragano1, Kenji Monde2, Koji Uwai1, Kiyotaka Tokuraku1 (1Grad. Sch. Eng.,
Muroran Inst. Tech., 2Fac. Adv. Life Sci., Hokkaido Univ.)– S170 –