Evaluation of medical materials degradation into several chemical agents～Using ATR FT-IR imaging～
The degradation and elution of plasticizer from several plastics by passing specific drugs through medical devices are well known.
ATR FT-IR imaging is a powerful tool for visualization of effect from the surface of various samples.
Polyvinyl chloride(PVC) and polycarbonate(PC) are common plastics used in medical devices.
We investigated degree of effect from these plastics after dipping chemical solutions.

Principle of ATR FT-IR (Attenuated Total Reflection) mode and feature of mapping measurement
Moving sample
stage/ATR crystal toacquisition images

sampleATRcrystal

Electric‐Field Penetration into sample
provides information of the sample
surface.

■ATR FT-IR imaging
provides variousInformation
・Degradation(structural change)
・Penetration(component distribution)
・Adhesive (cure extent)
・Diffusion, Compatibility
・Dispersion■Materials for ATR FT-IR imaging
・Polymeric materials
Industrial material, Packaging material,
Medical material etc
・A part of the specimen
Hair, Skin, Tissue etc
・Medicinal drug
・Foreign object matter■Features
・Collect sample information approximately 1μm
depth from sample surface.
・Using simple section allow ATR FT-IR imaging
・Spatial resolution: approximately 3～5 μm.
・Maximum mapping region: 400 μm×400 μm.

Materials and Methods
Ingredients in intravenous infusion for anti-tumor agent (5 mL)■The potential problems using PVC and PC as medical devise.
Medical devices(Materials)

Macrogol 300 (3240 mg)

Potential problems

Three way stop cock, Luer taper etc. Fat emulsion, Additives cause liquid(PC, PMMA, ABS)
leakage, Crack
Administration sets etc.
The elution of plasticizer from(PVC)
administration sets・Pinhole caused by ethanol
Tracheal tube
・A damage caused by elution of(PVC)
plasticizer.

Polysorbate 80 (400 mg)

Hironori Nakamura, Sachiko Kanazawa, Yasuyuki Furuta, Yumi Arai,
Kensuke Ishii and Shinichi Sugiura/Journal of Japanese Society of
Hospital Pharmacists/51, 1045‒1063(2015)

Benzyl alcohol (100 mg)*【Dipping method】
PVC or PCO
*O

←←←

OOO

Chemical solutions

OHOHOOHO

Dipping(Day15、30、80 and 130)
(Place protected from light in room temperature)

OOH

Washed by pure water and dry
CH3CH2OH

Ethanol (2.5 mL)

We studied the effect of PVC and PC during the dipping ofseveral chemical solutions without dilution.

Elution of plasticizer(Phthalic ester) from PVC caused by chemical solutions
Surface：Day 0：Day 15：Day 30：Day 80：Day 130‐CHCl‐
δCH

A remarkable change of PVC
in the benzyl alcohol wasCH2observed.
δCHCH2rocking‐CHCl‐
δCH
CH2rocking

CH2
δCH

Time‐dependentchange

Peak area ratio of 1725 cm-1/965 cm-1

ν：Stretching
δ：Bending
Φ：Aromatic ring

νC=O
νC=ONo dipping
Pure water
Macrogol 300Polysorbate 80
Ethanol
Benzyl alcohol★：Phthalic ester★：Phthalic ester
1800

1600

1400
1200
Wavenumber

1000

Stacked view of FT-IR-ATR spectra of surface of PVC
dipped by several chemical solutions during 130 days.

1800

1600

1400
1200
Wavenumber

A quantitative depth
profiling with elutionof phthalic ester wastime‐dependent.

FT-IR-ATR imaging
enables tovisualize degree ofplasticizer elution
in depth.

1000

Time-series variation of the effect of PVC surface dippedby benzyl alcohol.

Day 0Day 15 Day 30 Day 80 Day 130

Concentration of phthalic ester in PVC.

Structural change of PC due to the dipping of chemical solutions
δC=O
δCH
δC=O
δCH

A remarkable change of PCband in the benzyl alcohol
was observed.

Φ‐O‐C

Effect on the shape of absorption peak
⇒ Increase of polymer crystallinity[1]？

SurfaceΦ‐O‐C

Absorbance around of 1260 cm-1

ν：Stretching
δ：Bending
Φ：Aromatic ring

νC=C
φ
Optical micrographOptical micrograph

νC=C
φ：Day 0：Day 15：Day 30：Day 80：Day 130

Benzyl alcohol
No dipping
Pure water
Macrogol 300
Polysorbate 80
Ethanol

1550

1450

1350
Wavenumber1250

1150

Stacked view of FT-IR-ATR spectra obtained on the surfaceof PC dipped in several chemical solutions during 130 days.

1500 1450

A quantitative depth
profiling with structuralchange of PC was time‐dependent.

FT-IR-ATR imaging
enables tovisualize degree ofdegradation indepth.

1400 1350 1300 1250 1200 1150
Wavenumber

Time-series variation of PC band shape dipped in benzyl alcohol.
[1] Philip S. Brown & Bharat Bhushan/Scientific Reports/6, Article number:
21048 (2016)

Day 0 Day 15 Day 30 Day 80 Day 130

Time series dependence on crystallization rate in PC.
P02101構造化学第１研究室20200415-2