The 94th Annual Meeting of the Physiological Society of Japan

企画シンポジウム 1C 会場  Planned Symposium 1

Hall CLectures

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

日韓合同シンポジウムー FAOPS2019に向けてー
心血管の機能と病態におけるミトコンドリア恒常性制御

Japan-Korea Joint Symposium – Towards FAOPS2019 –Mitochondrial homeostasis in cardiovascular function and disease

Symposia

オーガナイザー・Organizer：
西田 基宏（自然科学研究機構岡崎統合バイオサイエンスセンター（生理学研究所）心循環シグナル研究部門）
Motohiro Nishida (Div Cardiocirc Signal, Okazaki Inst Integr BioSci (Natl Inst Physiol Sci), NINS)Jin Han (Dept Physiol, Col Med, CMDC, Inje Univ)

1PS01C1-1

Cardiac mitochondrial defects in the sepiapterin reductase KO mouseJin Han, Hyoungkyu Kim, Taehee Ko, Nari Kim, Sung-Ryul Lee, Kyungsoo Ko,
Byoungdoo Rhee
ミトコンドリアtRNA修飾によるタンパク質恒常性の維持機構○魏 范研1，鈴木 勉2，富澤 一仁1
1熊大・院医・分子生理，2東京大学大学院工学系研究科化学生命工学専攻

Regulation of cellular protein homeostasis by mitochondrial tRNA modification
Fan-Yan Wei1, Tsutomu Suzuki2, Kazuhito Tomizawa1

1Dept Mol Physiol, Faculty of Life Sci, Kumamoto Univ, Kumamoto, Japan, 2Dept Chem Biotech, SchEngineering, Univ Tokyo, Tokyo, Japan

1PS01C1-3

平滑筋Ca2+シグナルにおけるミトフュージン2の生理機能○山村 寿男，川崎 桂輔，稲垣 奏，鈴木 良明，今泉 祐治
名市大・院薬・細胞分子薬効解析

Physiological functions of mitofusin 2 on cytosolic Ca2+ signaling in smoothmuscle cells
Hisao Yamamura, Keisuke Kawasaki, Sou Inagaki, Yoshiaki Suzuki, Yuji Imaizumi
Dept Mol Cell Pharmacol, Grad Sch Pharmaceut Sci, Nagoya City Univ, Nagoya, Japan

1PS01C1-4

心筋ミトコンドリア動態のレドックス制御機構○西田 基宏1,2,3,4
1 岡崎生理研統合バイオ・心循環，2 九州大・院薬・創薬育薬研究施設，3 総研大・生理科学専攻，4JST さきがけ「疾患代謝」

Mechanism underlying redox regulation of cardiac mitochondria dynamics
Motohiro Nishida1,2,3,4

教育プログラム

Posters Day 1

1PS01C1-2

Posters Day 2

Dept Physiol, Col Med, CMDC, Inje Univ, Busan, Korea

2Dept Transl Pharm Sci, Grad Sch Pharm Sci, Kyushu Univ, Fukuoka, Japan, 3Dept Physiol,SOKENDAI, Okazaki, Japan, 4JST, PRESTO

Aims & Scope
Maintenance of organellar functions has been now attracted attention as a new strategy for the prevention ofcardiovascular diseases. Especially, mitochondria plays pivotal roles including energy production, Ca2+ handling, andautophagy. Mitochondrial dysfunction causes various muscular refractory diseases. Mitochondrial dynamics are preciselyregulated by various environmental factors, such as hypoxia, oxidative stress (including electrophilic environmentalpollutants) and hyperglycemia, and failure of mitochondrial quality control will increase the risk of cardiovascular diseases.
In this symposium, we will introduce cutting-edge researches on the molecular mechanisms underlying controlling
mitochondrial quality, and consider new strategies for the prevention or treatment of cardiovascular diseases.
61Posters Day 3

1Div Cardiocirc Signal, Okazaki Inst Integr BioSci (Natl Inst Physiol Sci), NINS, Okazaki, Japan,

第94回⽇本⽣理学会⼤会

企画シンポジウム 8C 会場  Planned Symposium 8Hall C

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30

日台合同シンポジウムー FAOPS2019に向けて
イオンチャネルの生理・病態生理

Japan-Taiwan Joint Symposium– Towards FAOPS2019 –Ion channels in physiology and patho-physiology
オーガナイザー・Organizer：
樽野 陽幸（京都府立医科大学大学院医学研究科 細胞生理学）
Akiyuki Taruno (Dept Mol Cell Physiol, Grad Sch Med, Kyoto Pref Univ Med)

Pei-Chun Chen (Dept Physiol, Grad Sch Basic Med, Natl Cheng Kung Univ)

2PS08C2-1CALHMチャネルによる味覚の神経伝達○樽野 陽幸1，丸中 良典1,21京都府立医大・院医・細胞生理，2京都府立医大・院医・バイオイオノミクス

Neurotransmission of taste mediated by calcium homeostasis modulator ion
channels
Akiyuki Taruno1, Yoshinori Marunaka1,2

1Dept Mol Cell Physiol, Grad Sch Med, Kyoto Pref Univ Med, Kyoto, Japan, 2Dept Bio-Ionomics,
Grad Sch Med, Kyoto Pref Univ Med, Kyoto, Japan

2PS08C2-2

Concerted trafficking regulation of Kv2.1 and KATP channels by leptin in
pancreatic β-cells
Pei-Chun Chen1, Yi Wu2, Show-Ling Shyng2

1Dept Physiol, Grad Sch Basic Med, Natl Cheng Kung Univ, Tainan, Taiwan, 2Dept Biochem andMol Biol, OHSU, USA

2PS08C2-3

少数の分子による嗅覚情報伝達チャネルの修飾○竹内 裕子，倉橋 隆
阪大・院・生命・生理

Modification of the olfactory transduction channel by small molecules
Hiroko Takeuchi, Takashi Kurahashi
Grad Sch Front Biosci, Osaka Univ, Japan

2PS08C2-4

Regulation of adult neurogenesis in the mouse SGZ by Kv1.1 potassium channel
Shi-Bing Yang
Inst Biomed Sci, Academia Sinica, Taipei, Taiwan

Aims & Scope
Towards the success of FAOPS 2019 in Japan, the Physiological Society of Japan (PSJ) has been organizing joint symposia
with FAOPS countries. Here, we would like to propose a joint symposium with the Chinese Physiological Society (CPS)(Taiwan). ThisCPS-PSJ joint symposium is focused on "ion channels in physiology and patho-physiology" and consists of 4
talks by 2 CPS speakers and 2 PSJ speakers.
Growing evidence has demonstrated that ion channels play important roles in health and diseases throughout our body.
Since ion channels mediate many physiological processes, malfunction of ion channels lead to diseases (a.k.a.
channelopathy). Thus, knowing ion channels involved in physiological systems and their regulatory mechanisms is crucial
for treating channelopathies. In this symposium, we would like to introduce recent advances in ion channel researches leadby Taiwanese and Japanese researchers. Taruno will talk about discovery of a novel ion channel that mediates
neurotransmission of tastes. Chen will present their work on concerted trafficking regulation of Kv2.1 and KATP channels byleptin in pancreatic β-cells. Takeuchi will introduce how the olfactory transduction channels are modified by smallmolecules. And finally, Yang will discuss regulation of adult neurogenesis by Kv1.1 channel.
72

The 94th Annual Meeting of the Physiological Society of Japan

企画シンポジウム 14C 会場  Planned Symposium 14

Hall CLectures

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50

日中合同シンポジウム―FAOPS2019に向けて―Computational physiologyの進展

Japan-China Joint Symposium – Towards FAOPS2019 –Progress in computational physiology

Symposia

オーガナイザー・Organizer：
松岡 達（福井大学医学部 統合生理学）
Satoshi Matsuoka (Dept Integ Sys Physiol Fac Med Sci Univ Fukui)

Jianwei Shuai (Dept Physics, Xiamen Univ)

3PS14C1-1

Simulation study of multiscale Ca2+ signals
Jianwei Shuai
Dept Physics, Xiamen Univ, China

3PS14C1-2

教育プログラム

小型中枢神経シナプスにおける伝達物質放出機構の実験とモデルによる解析○川口 真也
同志社大・脳科学研究科

Experimental and model analysis of transmitter release mechanisms at small
presynaptic terminals in the CNS
Shinya Kawaguchi

3PS14C1-3

Posters Day 1

Grad Sch Brain Sci, Doshisha Univ, Kyoto, Japan

心臓ミトコンドリアエネルギー代謝のCa2+調節に関するシミュレーション研究○松岡 達1，竹内 綾子1，齋藤 隆太2，姫野 友紀子31福井大学・医・統合生理，2田辺三菱製薬・先端医薬研究所，3立命館大学・生命科学・生命情報A simulation study on Ca2+ regulation of energy metabolism in cardiac
mitochondria
Satoshi Matsuoka1, Ayako Takeuchi1, Ryuta Saito2, Yukiko Himeno3

Tanabe Pharma Co. Saitama, Japan, 3Dept Bioinfo, Col Life Sci, Ritsumeikan Univ, Shiga, Japan

3PS14C1-4（AP4）

心臓興奮伝導における生理学的および病態生理学的モデリング研究○津元 国親，倉智 嘉久
大阪大・院医・薬理Physiological and pathophysiological modeling studies of excitation conductionin the heart: prediction from changes in the subcellular Na+ channel distribution
Kunichika Tsumoto, Yoshihisa Kurachi

Posters Day 2

1Dept Integ Sys Physiol Fac Med Sci Univ Fukui, Fukui, Japan, 2Adv Drug Res Lab Mitsubishi

Aims & Scope
Mathematics and computational analysis have been useful tools for integrative and quantitative understanding of logic oflife, physiology. The application has been widely spreading. In this symposium, we will introduce recent progress ofcomputational physiology in China and Japan to further facilitate quantitative research using computation. Profs. Shuai(China), Kawaguchi, Tsumoto and Matsuoka will present simulation-based physiological study on multiscale Ca2+ signals,
transmitter release dynamics at a small CNS presynaptic terminal, electrical conduction in the physiological andpathophysiological heart and cardiac energy metabolism, respectively. We expect this symposium will foster collaborative
works in physiology between China and Japan.

81Posters Day 3

Div Pharma, Grad Sch Med, Osaka Univ, Osaka, Japan