᧓ឋࣱᏍ໒ƷȐǤǪȞȸǫȸƱƠƯƷૼᙹᐯࠁ৴˳Ʒӷ‫ܭ‬㻵㼐㼑㼚㼠㼕㼒㼕㼏㼍㼠㼕㼛㼚㻌㼛㼒㻌㼚㼑㼣㻌㼍㼡㼠㼛㼍㼚㼠㼕㼎㼛㼐㼕㼑㼟㻌㼒㼛㼞㻌㼐㼕㼍㼓㼚㼛㼟㼕㼟㻌㼛㼒㻌㼕㼚㼠㼑㼞㼟㼠㼕㼠㼕㼍㼘㻌㼜㼚㼑㼡㼙㼛㼚㼕㼍་Ꮫ㒊 ෆ⛉Ꮫ⣔䞉࿧྾ჾෆ⛉Ꮫศ㔝 ෸ᩍᤵᶒ ᑀ༤

Yasuhiro Gon, Department of Internal Medicine, Division of Respiratory Medicine,
Nihon University School of Medicine┠ⓗ䞉⫼ᬒ䠄Purpose andBackground䠅᧓ឋࣱᏍ໒ᲢKPVGTUVKVKCNRPGWOQPKCᲣƸŴᏍᏘ᧓ƷᨠُưƋǔᏍƷ᧓ឋኵጢƴƓƚǔ໒ၐࣱ၌धƷዮᆅưƋǔŵ᧓ឋࣱᏍ໒ƷᡶᘍƴˤƍŴ᧓ឋኵጢƷዴዜ҄ƕဃơŴधᎍƷԠԈ‫׉‬ᩊƷҾ‫׆‬ƱƳǔŵ᧓ឋࣱᏍ໒ƸŴᐑҾ၏ǑǔǋƷŴᕤдᛔឪࣱŴᎰಅᒉƠƘƸ࿢‫ؾ‬ƴǑǔǋƷƳƲƷҾ‫׆‬ƕଢǒƔƳɟ፭ƱŴҾ‫׆‬ɧଢƷɟ፭Ʊƴ‫ٻ‬КƞǕǔŵҾ‫׆‬ɧଢƷǋƷƸŴཎႆࣱ᧓ឋࣱᏍ໒ᲢKFKQRCVJKEKPVGTUVKVKCNRPGWOQPKCUŴ++2UᲣƱԠƹǕŴμᢿưᲱƭƷ၌धƴЎ᫏ƞǕǔ ᘙᲫ ŵɶưǋŴཎႆࣱᏍዴዜၐƸʖࢸɧᑣưƋǓŴ঻ƕ‫׎‬ưƸᩊ඙ࣱ၌धƱƠƯཎ‫ܭ‬၌धƴਦ‫ܭ‬ƞǕƯƍǔŵஜ၌धǛᄩ‫ܭ‬ᚮૺƢǔƨǊƴƸŴᐮ࠿৑ᙸŴဒ΂৑ᙸŴᏍƷೞᏡᚸ̖Ŵ‫ٳ‬ᅹႎᏍဃ౨ƴǑǔ၏ྸኵጢ‫ܖ‬ႎ৑ᙸሁƴؕƮƘዮӳЙૺǛᘍƏ࣏ᙲƱƳǔƨǊŴǑǓቇ̝ưŴƔƭŴ᭗ƍࣱᨗྙӏƼཎီࣱǛǋƬƯཎႆࣱ᧓ឋࣱᏍ໒ŴཎƴཎႆࣱᏍዴዜၐƷᚮૺ૾ඥƷ᧏ႆƕࢍƘ൭ǊǒǕƯƍǔƷƕྵཞưƋǔŵཎ⌮䞉᪉ἲ䠄Principles andMethods䠅ଐஜԠԈ֥‫˟ܖ‬ƴǑǔᚮૺǬǤȉȩǤȳӏƼ#65'45,45#.#65VCVGOGPVƴؕƮƖཎႆࣱᏍዴዜၐ KFKQRCVJKERWNOQPCT[HKDTQUKU+2( ƴؕƮƍƯ+2(ƱᚮૺƠƨŵཎႆࣱᏍዴዜၐᲢ+2( ̊Ŵ‫ݣ‬ᝋ၌धƱƠƯ05+2Ჲ̊Ŵ ӏƼᢅ૓ࣱᏍᐥ໒̊Ɣǒᘉ෩Ǜ੔ӕƠᘉฌǛЎᩉƠƨŵǇƨŴ‫ݣ‬ᝋǛ+2(ƴ፝धƠƯƍƳƍͤࠝᎍ̊ƱƠŴ੔ᘉࢸᘉฌǛЎᩉƠƨŵŪ ᄂᆮᲫ
2TQVQ#TTC[ƸŴȒȈǿȳȑǯឋȞǤǯȭǢȬǤƴƸŴᆔˌɥƷ‫ܦ‬μᧈȒȈǿȳȑǯឋƕᲬǹȝȃȈ઀᠍ƞǕƯƍǔǿȳȑǯឋȞǤǯȭǢȬǤưƋǔᲢ‫׋‬ᲫᲣŵधᎍᘉฌӏƼ‫ݣ‬ༀ፭ƷᘉฌƴƭƍƯŴȩǤȕȆǯȎȭǸȸǺᅈƕ੩̓Ƣǔ2TQVQ#TTC[ȒȈǿȳȑǯឋȞǤǯȭǢȬǤǛဇƍƯŴᘉฌɶƴ‫܍‬‫נ‬Ƣǔᐯࠁ৴˳ƷȗȭȕǡǤȫǛ൭ǊƨŵࢽǒǕƨኽௐǛᚐௌƠŴधᎍ፭ƷᘉฌɶƴŴ‫ݣ‬ༀ፭ƱൔƠƯŴᐯࠁ৴˳ƕ‫ٶ‬Ƙ‫נ܍‬Ƣǔ৴ҾǿȳȑǯឋǛᢠ‫ܭ‬ƠƨŵŪ ᄂᆮᲬȒȈȷȪǳȳȓȊȳȈ7$'6ǿȳȑǯǛȞǤǯȭȗȬȸȈƴ‫҄ޖ׍‬ƠŴधᎍᘉฌӏƼ‫ݣ‬ༀ፭ƷᘉฌǛǵȳȗȫƱƠƯŴ7$'6ཎီႎ৴˳ƴ‫ݣ‬Ƣǔ'.+5#Ǜ˺঺Ơƨŵ‫׋‬Ძ⤖ᯝ䠄Results䠅Ū ᄂᆮƷኽௐ धᎍ፭ƷᘉฌɶƴŴ‫ݣ‬ༀ፭ƱൔƠƯŴᐯࠁ৴˳ƕ‫ٶ‬Ƙ‫נ܍‬Ƣǔ৴ҾǿȳȑǯឋǛਁЈƠŴᘙᲬƷǑƏƴᲫ᳸Ʒǿȳȑǯឋƕӷ‫ܭ‬ƞǕƨŵCount
Database ID

Ultimate ORF
ID

NM_014176.1
BC008730.2

IOH3736
IOH5942

NM_176783.1

IOH40962

BC032654.1
BC017059.1
NM_016433.3

IOH21978IOH11123
IOH57161

Description
ubiquitin-conjugating enzyme E2T (putative) (UBE2T)
hexokinase 1 (HK1)proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)(PSME1), transcript variant 2
USO1 homolog, vesicle docking protein (yeast) (VDP)
Gamma-interferon-inducible protein Ifi-16
Glycolipid transfer protein

PrevalenceGroup Average

1764
3907

Difference(Patient Control
1459
3738

Ratio
(Patient/Control)
5.8
23.2

289

1380

1091

4.8

176
4161
508

1489
6015
1306

1312
1854
798

8.4
1.4
2.6Control

PatientControl

Patient

P-Value

CutoffControl

Patient

00

16
87%
7%

68%
36%

6.04E-05
2.08E-02

664
419

305
168

087%

36%

2.08E-02881

0116887%14%14%

28%36%
36%

6.22E-02
9.49E-02
9.49E-02

8445158834ᘙᲬ ᣐЗဪӭᲫ᳸ưᅆƞǕǔǢȟȎᣠᣐЗƔǒƳǔǿȳȑǯឋȞȸǫȸƴƭƍƯŴ2TQVQCTTC[ƷኽௐǛᅆƢŵ2CVKGPVᲷ+2(Ū ᄂᆮᲬƷኽௐĬᲵ‫׋‬Ӳᆔ᧓ឋࣱᏍ໒धᎍƷᘉฌɶƷ7$'6ǿȳȑǯឋ᣽Ʒ‫ܭ‬᣽ኽௐŪ ᄂᆮᲬƷኽௐĭᲵ‫׋‬7$'6Ʊ*-Ʒᐯࠁ৴˳ƴǑǔ+2(ᚮૺƷ41%୺ዴ
UBE2T

2,500

250,000

2,000

200,000

1,000

150,000

Sensitivity (%)

1,500

Sensitivity (%)

HK1 (ng/ml)

UBE2T (ng/ml)

100

75

5025

100,000

0025

5075

100

Specificity (%)
500

50,000Ū ᄂᆮᲬƷኽௐĮᲵᘙͤࠝᎍŴ+2(Ŵ05+2ၐ̊ƴƓƚǔ7$'6Ʊ*-ᐯࠁ৴˳ƷࣱᨗᎍૠƱࣱᨗྙ
0%QPVTQNlroont

HIPUISIPPCNfN

ormalPHIPUfNSIP0䜎䛸䜑䠄Summary䠅ཎႆࣱ᧓ឋࣱᏍ໒Ტ+2(ᲣƷᙀяᚮૺƴဇƍǔƨǊƷȞȸǫȸŴӏƼཎႆࣱ᧓ឋࣱᏍ໒ǛᚮૺƢǔƨǊƷǭȃȈǛ੩̓ƢǔŵஜᄂᆮƴǑǓŴቇ̝ƴŴƔƭŴ᭗ƍࣱᨗྙӏƼཎီࣱǛǋƬƯཎႆࣱ᧓ឋࣱᏍ໒ƷᚮૺƕӧᏡƱƳǔƱ஖ࢳƞǕǔŵǇƨŴஜႆଢƴǑǓŴཎႆࣱ᧓ឋࣱᏍ໒Ʒଔ஖ƷᚮૺƕӧᏡƱƳǓŴଔ஖Ʒ඙ၲ᧏‫ڼ‬ƕӧᏡƱƳǓŴᢘЏƳϼፗǛ଀ƢƜƱưŴधᎍƷ31.ƷӼɥƕ஖ࢳưƖǔŵǇƨŴஜႆଢưᙸЈƠƨ৴˳Ǜ೅ႎƱƠƨཎႆࣱ᧓ឋࣱᏍ໒Ʒ඙ၲᕤƷ᧏ႆǋ஖ࢳƞǕǔŵ

6QVCNUCORNG
ɲ૾ᨏࣱ7+205+2  

ᲢᲟᲣ

7$'6ࣱᨗ  

*-ࣱᨗ  ᲢᲟᲣ

ƲƪǒƔɟ૾ࣱᨗ  ᲢᲟᲣ 

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