2018 年度（平成 30 年度）
研究部門名

化学研究部門

講座名

生体機能化学講座

教員名

坂根 郁夫

電子メール

sakane 理 faculty.chiba-u.jp（１）研究論文などのリスト（印刷中を含む）
著者・発表者
等

タイトル

発表雑誌・会合

巻・等

号

Biochimie

151

発行・発

掲載論文の DOI（付与され表年等ている場合）

2018

10.1016/j.biochi.2018.05.017

2018

10.7717/peerj.5449

54–60

2018

10.1016/j.bbrc.2018.08.119

229–2322018

10.1089/mab.2018.0026

頁

Diacylglycerol kinase 
Sakai, H.,
controls
Murakami, C.,(１)

down-regulation of
Matsumoto, K.,

45–53

cyclin D1 for C2C12Urano, T. andmyogenic
Sakane, F.
differentiationExpression andpurification of human
diacylglycerol kinase (2)ArticleTakahashi, D.
fromPeerJ

6e5449, 1–

and Sakane, F.
baculovirus-infected18

insect cells forstructural studies(3)

Maeda, Y.,

Diacylglycerol kinase 

Shibata, K.,

induces filopodium

Akiyama, R.,formation via its C1,

Murakami, C.,

catalytic andBiochem.

Takao, S.,

carboxy-terminal

Biophys. Res.

504
(1)
Murakami, Y.,

domains and interacts

Takahashi, D.,with theSakai, H. andRac1-GTPase-activating

Sakane, F.

protein, 2-chimaerinCommun.

Nakano, T.,Ogasawara, S.,
Tanaka, T.,
Hozumi, Y.,(4)

DgMab-6: anti-human

Monoclon.

DGKγ monoclonal

Antib.

37

antibody forImmunodiagn.

(5)

immunocytochemistry

Immunother.

Yamaki, A.,
Sakane, F.,
Shirai, Y.,
Nakamura, T.,
Yanaka, M.,

Yamada, S.,
Kaneko, M. K.,
Kato, Y. andGoto, K.
Yamaki, A.,
Akiyama, R.,
Murakami, C.,(5)

Takao, S.,

Diacylglycerol kinase

Murakami, Y.,-selective inhibitors

Mizuno, S.,

induce apoptosis andJ. Cell.

Takahashi, D.,

reduce viability ofBiochem.

Kado, S.,

melanoma and several

Taketomi, A.,

other cancer cell lines(in press)

10.1002/jcb.28288

J. Biochem.

(in press)

10.1093/jb/mvz008

Protein Sci.

(in press)

10.1002/PRO.3572

ACS Omega(in press)

Shirai, Y.,
Goto, K. andSakane, F.
Hayashi,(6)D.,

Tsumagari, R.,

Screening of subtype

Liu, K., Ueda,

specific activators andS., Yamanoue,

inhibitors for

M., Sakane, F.

diacylglycerol kinase

and Shirai, Y.
Takahashi, D.,
Crystalstructure andSuzuki, K.,
calcium-induced(7)

Sakamoto, T.,
conformational changesIwamoto, T.,of diacylglycerol kinase
Murata T. and EF-hand domains

Sakane, F.
Expression, purification
Saito, T.,(8)

and characterization ofTakahashi, D.
human diacylglycerol
and Sakane, F.

kinase （２）卒業研究、大学院修士および博士論文修了指導人数
・卒業研究

4名

・大学院修士3名

・大学院博士0名（３）教育業績（自己申告、テキストの作成など、授業の工夫など）なし

（４）国際会議出席と招待リスト
1

Sakai, H. and Sakane, F. Diacylglycerol kinase  phosphorylates phosphatidylcholine-specific phospholipase C-dependent,
palmitic acid-containing diacylglycerol species in response to high glucose levels. In: 1st International Symposium on SoftMolecule Activation Research Center: Chiba, Japan, August 31–September 1, 2018

2

Lu, Q., Komenoi, S., Takahashi, D. and Sakane, F. Abnormalities of the serotonergic system in diacylglycerol kinaseδ-deficient mouse brains. In: 1st International Symposium on Soft Molecule Activation Research Center: Chiba, Japan,August 31–September 1, 20183

Murakami, C. and Sakane, F. Studies of interaction between diacylglycerol kinase  and diacylglycerol-generating enzymes. In: 1stInternational Symposium on Soft Molecule Activation Research Center: Chiba, Japan, August 31–September 1, 20184

Hoshino, F. and Sakane, F. Identification of proteins selectively binding to palmitic acid-containing phosphatidic acid species in mouseskeletal muscle. In: 1st International Symposium on Soft Molecule Activation Research Center: Chiba, Japan, August 31–
September 1, 2018

5

Lu, Q., Komenoi, S., Takahashi, D. and Sakane, F. Abnormalities of the serotonergic system in diacylglycerol kinaseδ-deficient mouse brains. In: 59th International Conference on the Bioscience of Lipids "Lipid Fluxes and Metabolism –From Fundamental Mechanisms to Human Disease": Helsinki, Finland: September 4–7, 2018（５）新聞や雑誌等で報道された研究成果等（報道媒体，報道年月日，報道内容等）
なし（６）国際並びに国内学会での受賞（賞名，その内容，受賞理由等）
なし（７）国際共同研究（共同研究名，研究内容等）
なし（８）地域・社会と連携した教育・研究活動，学会、国、県などへの協力，など
なし（９）特許（発明者名，発明の名称，出願日，出願番号，整理番号等）（現時点で公表できるもののみ）なし（１０）その他なし