7CiRA Recruitment
T-CiRA Program-Specific Researcher, Hotta Lab
Position
Work location

One Program-Specific Researcher (Specially Contracted Limited-Term Staff)
T-CiRA Hotta Project (In vivo Genome Editing Therapy Project)
Center for iPS Cell Research and Application (CiRA), Shonan Branch
26-1, Muraoka-Higashi 2-chome. Fujisawa, Kanagawa, Postal code: 251-8555, Japan※15-min Bus ride from JR Ofuna or Fujisawa station※Home, etc., if telecommuting is permitted or ordered by Kyoto University.
https://www.shonan-health-innovation-park.com/en/access/Job description

With the Hotta Project in T-CiRA Program, we are conducting research and development of a novel
genome editing therapy for Duchenne muscular dystrophy. So far, we have developed various genedelivery techniques, such as LNP, AAV, and VLP, and demonstrated the efficacy and safety using
patient’ iPS cells and animal models [Ref: Kenjo E et al., Nat Com, 2021 | Gee P et al., Nat Com, 2020 |Morisaka H et al., Nat Com, 2019 | Li HL et al., Stem Cell Reports, 2015].
The T-CiRA project, which is a 10-year project started in April 2016 as a collaboration with theCiRA and Takeda, will promote research and development for clinical application of innovative
therapeutics based on groundbreaking basic research. In this unique industry-university collaborative
project, we are conducting research aiming to develop a therapeutic method that has a scientific impact
and a benefit to patients.
“Act for the Promotion of Science, Technology, and Innovation” will be applied to this position.

For details of T-CiRA and our research, please visit the sites below:

Job requirements

T-CiRA Program:

https://www.takeda.com/what-we-do/t-cira/CiRA Hotta Lab:

http://www.cira.kyoto-u.ac.jp/hotta/en/

He/she has (or expects to have) a Ph.D. or equivalent professional achievements/capabilities inmedicine, dentistry, pharmacology, science, or engineering.
・ Enthusiastic about the research and development of muscle disease treatment methods using genomeediting.
・ Motivated to acquire and develop new experimental methods.
・ Can work as a member of our team with researchers from academia, Takeda Pharmaceutical, andrelated companies.
【Desired capabilities】
・Research experiences in the research field of DDS and cellular entry.
・Research experiences in the research field of CRISPR genome editing.
・Research experiences in the research field of muscular dystrophy model animals.

Contract period

Start day (negotiable) ~ March 31st, 2025 with a possibility of renewal until up to the end of the project.
When the contract term has expired, the employment contract terminates. Renewal of the contract at
the expiration of the limited-term employment contract is decided comprehensively, taking into
consideration the workload, work performance, behavior, capabilities, progress of the work engaged in,etc. at the end of the contract term. No matter how excellent your work performance, behavior, andcapabilities have been, there are cases in which the contract is not renewed on account of unavoidable
reasons, such as loss of the job contents specified above due to reassignment of your lab’s principal
investigator or reorganizations or change of financial status and acceptance status of external fund for theemployment.
Probational period

Workingconditions

6 months
Kyoto University Program-Specific Researcher (full-time, annual salary system)
・ Salaries, etc. are determined based on the Kyoto University standards and according tocapabilities and backgrounds.
・ Annual salary includes various allowances.
・ Discretionary work system for specialist staff (38 hours and 45 minutes/week, 7 hours and 45minutes/day)
・ 8:30am ~ 5:15pm (break 12:00pm ~ 1:00pm)/ 5 days a week, when Discretionary work system forspecialist staff is not applied.
・ You may be ordered to work overtime as needed.
・ Holidays: Saturdays, Sundays, national holidays, year-end and new-year break, the anniversary offoundation holiday, and paid holidays
・ MEXT Mutual Aid Association, employee pension insurance, industrial accident compensation
insurance, and employment insurance

Deadline forapplication
Documents to besubmitted

Until the position is filled.
Please submit the following documents:（If you request additional materials, please specify them.）
1. Curriculum vitae (Form 1)
Please write names and contact information of two referees who can evaluate you. Please write
the email address and telephone number by which we can unfailingly contact you in the designatedspace.
2. List of research achievements or professional achievements (publications, presentations, acquired
research funds, patents, etc.) (Form 2)
3. Outlines of research progress and research results in the past (Form 3)※Please use the Forms 1 through 3 for the documents required above. You will find the Forms fordownloading at: http://www.cira.kyoto-u.ac.jp/e/employment/img/doc/Application_Forms.zip
If you do not find appropriate items in the Forms, please add items to the Forms as needed.

※Additional information may be requested in the process of screening.
Contact

Please send the application documents to the following address by postal mail or e-mail.
Hotta Lab, Center for iPS Cell Research and Application, Kyoto University
53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, JAPANE-mail: akitsu.hotta*cira.kyoto-u.ac.jp（Please change “*” to “＠”.）・ Please be sure to write “Application documents for Program-Specific Researcher of Hotta Lab” on
the envelope or in the subject line of the e-mail.

・ If you make inquiries about job specifications or working conditions, please contact Hottamentioning in the subject line as: “Recruitment of Program-Specific Researcher of Hotta Lab”
Selection process

An interview will follow the screening of application documents. Those who have passed the screening
will be informed of the date and time of the interview via e-mail or in writing and may be requested togive a lecture on the research or professional achievements at the interview. (Interviewees will bear theirtransportation and accommodation expenses for the interview.)
Results will be informed via e-mail or in writing as soon as the decision is made.

Gender equality
Others

Kyoto University is promoting gender equality. Female researchers are encouraged to apply
Submitted documents shall be used just for the selection, and never be disclosed, transferred, or lent tothe third party without due reasons.
Please be advised that submitted documents shall not be returned.
Kyoto University is working to prevent passive smoking, by prohibiting indoor smoking on all
campuses and also outside smoking except designated areas.

We are looking for a postdoctoral fellow who is interested in Academia-Industry collaboration
to develop genome editing therapy for muscular dystrophy.
We are looking forward to your application!