WCRB PROGRAM

Sunday, 9 October 2011
WCRB Registration Opens
4:00 PM - 6:30 PMFoyer

WCRB Welcome Reception
6:00 PM - 7:30 PMCairns Convention Centre

Monday, 10 October 2011
Registration desk open
7:30 AM - 5:00 PMFoyer

Plenary Lecture 1
8:30 AM - 9:30 AM
Chair: Charles AllanPeter Koopman
Foundations of Fertility: Signaling pathways regulating fetal germ cell
developmentabs#080
The WCRB acknowledges the support of:Morning Tea
9:30 AM - 10:00 AMHall A

Foyer

Concurrent symposia sessions I-III
Session I: Periconception origins of postnatal development and disease
10:00 AM - 12:00 PMHall A
Chairs: Rebecca Robker, Wee Ching Kong
10:00am
Tom Fleming
Rodent preimplantation maternal low protein diet model and adult cardiovasculardiseaseabs#081
10:30am
Kevin Sinclair
One-carbon metabolism and epigenetic programming in the oocyte and pre-implantationembryoabs#082
11:00amCaroline McMillen
Maternal obesity and the early origins of childhood obesity: Weighing up the benefits and costsof maternal weight loss in the periconceptional period for the offspringabs#083
11:30amTod Fullston
Diet induced paternal obesity epigenetically modifies sperm and impairs the reproductive
health of two subsequent generations in a mouse model.
abs#084
11:45am
Xiang-Hong Ou
Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction inoocytes
abs#085

Session II: Molecular control of meiotic progression
10:00 AM - 12:00 PM
Chairs: Janet Holt, Jeremy Thompson
10:00amMary Ann Handel
Regulation of exit from meiotic prophaseabs#086
10:30amKeith Jones
Cdh1/Fzr1 in the maintenance of prophase arrest and prevention of aneuploidy
11:00amQing-Yuan SunMechanisms regulating accurate chromosome segregation during mouse oocyte
meiosisabs#088
11:30am
Greg Fitzharris
Chromosome segregation in mammalian oocytes
abs#089

Room 1 & 2

abs#087

Session III: Revelations in neuroendocrine control of reproduction
10:00 AM - 12:00 PM
Room 3 & 4
Chairs: John Nilson, Chris Scott
10:00amIain Clarke
Metabolic regulation of the reproductive Axis
abs#090
10:30amHiroaki Okamura
GnRH pulse generation by hypothalamic kisspeptin/neurokinin b/dynorphin neurons
abs#091
11:00am
Kevin Murphy
The design of a kisspeptin-10 analogue with greater in vivo bioactivity than kisspeptin10.
abs#092
11:30amCheryl Ashworth
Effects of pre-natal stress and post-natal pain on the steroidogenic capacity of young piggonads
abs#093
11:45amStephanie Lee
A transcriptomic examination of sexual differentiation in zebrafish
abs#094
Lunch Break
12:00 PM - 1:00 PMFoyer

Plenary Lecture 2
1:00 PM - 2:00 PM
Chair: Qing Yuan Sun
Haibin Wang
Molecular determinants of blastocyst competency for implantation

Hall A

abs#095

The WCRB acknowledges the support of the: Chinese Society for Reproductive Biology

Concurrent symposia sessions IV-VISession IV: Understanding ovarian function to maximise animal production
2:00 PM - 3:30 PMHall AChairs: Helen Irving-Rodgers, Masafumi Tetsuka
2:00pmMilo Wilbank
Sex and the single follicle: Mechanisms involved in selection of one or multiple dominantfollicles in cattle
abs#096
2:30pmKenneth McNatty
Hierarchical ovarian follicular development and ovulation-rate
abs#097
3:00pmKiyoshi OKUDA
Factors and microenvironments regulating CL function - hypoxia in luteal physiology abs#098

Session V: Sperm development and function
2:00 PM - 3:30 PMChairs: Mai Sarraj Liza O’Donnell
2:00pmCharles Allan
Steroidal control of Sertoli cell and spermatogenic developmentabs#099
2:30pmWei YanRegulation of spermatogenesis by small non-coding RNAs
abs#100
3:00pmShosei Yoshida
Sperm stem cell behaviors in mouse testis
abs#101

Room 1 & 2

Session VI: Preserving and preventing fertility
2:00 PM - 3:30 PM
Room 3 & 4
Chairs: Guiying Nie, William S Yeung
2:00pmTeruhiko Wakayama
Development of novel cloning and ART methods for animal production and species
preservation
abs#102
2:30pmJohn Aitken
Pioneering therapies to preserve or prevent sperm function and to protect against Sexually
Transmitted Diseases (STDs)
abs#103
3:00pmEvdokia Dimitriadis
Regulation of implantation at the fetal-maternal interface: Opportunities for new
contraceptives.
abs#104

Afternoon Tea
3:30 PM - 4:00 PMFoyer

Plenary Lecture 3
4:00 PM - 5:00 PM
Chair: Jock Findlay
John Eppig
Oocytes Under Arrest: A “Whodunit”

Hall Aabs#105

The WCRB acknowledges the support of:

WCRB Posters: - Session 1
5:00 PM - 6:30 PMHall BTuesday, 11 October 2011
Registration Desk Open
7:30 AM - 5:00 PMFoyer

Plenary Lecture 4
8:30 AM - 9:30 AM
Chair: Chang-Gyu Lee
Nam-Hyung Kim
The role of microRNAs on the epigenetic regulation of fertilized and cloned embryo
developmentabs#110

Hall A

The WCRB acknowledge the support of the: Korean Society for Animal Reproduction

Morning Tea
9:30 AM - 10:00 AM

Foyer

Concurrent symposia sessions VII-IX
Session VII: Advances in germ line stem cell production
10:00 AM - 12:00 PMHall A
Chairs: Gary Hime, Kate Loveland
10:00amJi Wu
Production of offspring from germ line stem cells in new born ovary
abs#111
10:30amShaorong Gao
Pluripotency and therapeutic potential of induced pluripotent stem cells
abs#11211:00amJeong Mook Lim
Knowledge from model; germline- or nongermline-derived, stem cell-like cells and theirapplication for deriving tissue-specific stem cells
abs#113
11:30am
Qi Zhou
Pluripotent stem cells and the potential application in regenerative medicine
abs#114

Session VIII: Molecular Control of Ovarian Function
10:00 AM - 12:00 PM
Room 1 & 2
Chairs: Karla Hutt, Bruce Murphy10:00am
Mats Brännström
Molecular mechanisms of ovulation
abs#115
10:30am
Rebecca Robker
Novel pathways linking adiposity and dysfunction of ovulation and oocytes
abs#116
11:00amRichard Anderson
The diverse roles of neurotropins in ovarian function
abs#117
11:30amMichel De Vos
Embryo yield and quality after non-hCG primed IVM and conventional ICSI in PCO
patients
abs#118
11:45am
Tomoko Nakamura
GDF-9 induces connexin 43 and enzymes of cholesterol biosynthesis in human granulosacells
abs#119

Session IX: New aspects of uterus and placental function
10:00 AM - 12:00 PM
Room 3 & 4
Chairs: Lois Salamonsen, Haibin Wang
10:00amSimon Riley
The essential role of the placenta and fetal membranes at the fetal-maternal interface for a
successful pregnancy and initiation of labour
abs#120
10:30am
Norihiro Sugino
Aberrant DNA methylation in uterine leiomyomas
abs#12111:00amKazuyoshi Hashizume
Novel factors involved in the cross-talk between mother and fetus during pregnancy:
Multinucleation and functions of bovine trophoblastic cells for implantation.
abs#122
11:30amJoanna James
Trophoblasts do not migrate retrograde to flow in low shear stresses: consequences for spiralartery remodelling in the first trimester of human pregnancy
abs#123
11:45am
Wai Sum O
The role of adrenomedullin in tubal ectopic pregnancy
abs#124

Lunch Break
12:00 PM - 1:00 PMFoyer

Plenary Lecture #5
1:00 PM - 2:00 PM
Chair: Greg FitzHarris
John Carroll
Time, space and energy in the mammalian oocyte

Hall Aabs#125

The WCRB acknowledges the support of:Concurrent symposia sessions X-XI
Session X: Gametes and early embryo development
2:00 PM - 3:30 PMHall A
Chairs: Ken Sawai, Keith Jones
2:00pmKazuo Yamagata
Genetic and epigenetic landscape of mouse preimplantation development revealed by live-cell
imaging
abs#126
2:30pmDong Jin
RNA polymerase II CTD regulation in mammalian oocytes and early embryos
abs#127
3:00pmSuzannah Williams
Embryos generated from oocyte lacking complex N- and O- glycans have compromised
implantation and development.
abs#128
3:15pmSimon Lane
Attachment, but not tension or position, mediated satisfaction of the SAC underlies thesusceptibility of mammalian oocytes to chromosome segregation defects.
abs#129

Session XI: Update on the Hypothalamo-Pituitary-Gonadal Axis
2:00 PM - 3:30 PM
Room 1 & 2
Chairs: Hiroko Tsukamura, Richard Lea
2:00pmJohn Nilson
Calcineurin and NFAT are new members of the GnRH transcriptional network
abs#130
2:30pmMary Hunzicker-Dunn
FSH Regulation of Lhcgr Expression in Granulosa Cells.
abs#131
3:00pmPaul Fowler
Environmental exposures and reproductive development and function in the female
abs#132

Session XII: Tailored Therapies for Reproductive Medicine
2:00 PM - 3:30 PM
Chairs: Ray Rodgers, Noruhiro Sugino
2:00pmStephen Hillier
The ovary from basic science to clinical translation
abs#133
2:30pmKylie Dunning
Ovarian Follicle Metabolism and Culture for Fertility Preservation.
3:00pmClaire Roberts
Parental genotype and risk for preeclampsia
abs#135

Room 3 & 4

abs#134

Afternoon Tea
3:30 PM - 4:00 PMFoyer

Plenary Lecture #6
4:00 PM - 5:00 PM
Chair: Darryl Russell
Johan Smitz
A roadmap to obtain competent oocytes from preserved ovarian tissue

Hall Aabs#136

The WCRB acknowledges the support of:

WCRB Posters- session 2
5:00 PM - 6:30 PM

Conference BBQ Dinner & Dance7:00 PM - 12:00 AM
Tickets required

Hall B

Outdoor Veranda and Hall D

Wednesday, 12 October 2011
Registration Desk Open
7:30 AM - 12:00 PM

Foyer

Plenary Lecture #7
8:30 AM - 9:30 AM
Chair: Noboru Manabe (TBC)
Hiroshi Nagashima
The interface between reproductive biology and regenerative
medicine
abs#140

Hall A

The WCRB acknowledges the support of:Morning Tea
9:30 AM - 10:00 AM

Foyer
Concurrent symposia sessions XII-XIV

Session XIII: Gamete quality challenges to healthy reproductive outcomes
10:00 AM - 12:00 PM
Chairs: Eileen McLaughlin, Suzannah Williams
10:00amEvelyn Telfer
Oocyte somatic cell interactions promoting follicle activation and development
10:30amWilliam Yeung
Glycodelin-C and the role of cumulus complex in natural sperm quality selection
11:00am
Takahiro Arima
Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients
11:30am
Jorma Toppari
Environmental modifiers of male reproductive functions
abs#144

Hall Aabs#142abs#141abs#143

Session XIV: Chromatin modifications and packaging in mature Sperm
10:00 AM - 12:00 PM
Room 1 & 2
Chairs: Moira O’Bryan, John Aitken
10:00amHisato KobayashiMouse gametic DNA methylomes show the role of intragenic DNA methylation in theestablishment of oocyte-specific heritable marks
abs#145
10:15am
Duangporn Jamsai
RNA binding motif 5 dysfunction causes male infertility in mice by disrupting spermatid
maturation
abs#146
10:30am
Douglas Carrell
Chromatin in human sperm, packaging genes for embryo developmentabs#147
11:00amHitoshi Kurumizaka
Structural and functional analyses of human nucleosomes containing testis-specific histone
variants
abs#148
11:30amShaun Roman
Nucleosome retention during chromatin packaging in human spermatozoa.
abs#149

Meeting Close
12:00 PM - 12:15 PM

Hall A