Program
Day 2: November 11th
9:30-9:45

Oral Presentations 1O-01 One-Step Synthesis of Cyclopentene Derivatives fromChair:Kohji Seio
Tokyo Institute ofTechnology

5′-Deoxy-5′-Heteroarylsulfonylnucleosides, NucleosideDerived Julia-Kocienski Reagents

Natsuhisa Oka,1,2,3,* Mayuka Kanda,1 Minami Furuzawa,1 Wakaba
Arai,1 Kaori Ando1,*
1

Department of Chemistry and Biomolecular Science, Faculty of Engineering,
Gifu University, 2Center for Highly Advanced Integration of Nano and LifeSciences, Gifu University (G-CHAIN) 3Institute for Glyco-core Research(iGCORE), Gifu University

1O-02 Functional Oligonucleotide
Information

9:45-10:00

Encoding

Metabolite

Tatsuya Nishihara1, Yuto Motohashi,1 Shuhei Moritani,1 Momoka
Yajima,1 Kazuhito Tanabe1,*
1

College of Science and Engineering, Aoyama Gakuin University

1O-03 Unnatural base pairs with spatially isolated hydrogenbonding units in the DNA major groove

10:00-10:15

Hidenori Okamura,1,2,* Zhuoxin Dong,1,2 Giang H. Trinh,1,2 Fumi
Nagatsugi1,2,*
1

Institute of Multidisciplinary Research for Advanced Materials, Tohoku
University, 2Graduate School of Science, Tohoku University
10:15-10:30

Oral Presentations 1O-04 Unnatural-base DNA sequencing method, Sanger gap

sequencing, for genetic alphabet expansion technology

Chair:

Michiko Kimoto,1,* Si Hui Gabriella Soh,1,2 Hirao Ichiro1,*Noriaki Minakawa

1Tokushima Univ.
10:30-10:45

Institute of Bioengineering and Bioimaging, A*STAR, 2Lee Kong Chian Schoolof Medicine, Nanyang Technological University

1O-05 Engineering Semisynthetic Organisms using UnnaturalBase Pairs
Koji Hashimoto,1,2,3 Emil C. Fischer,1 Floyd E. Romesberg1,*
1

Department of Chemistry, The Scripps Research Institute, 2Department ofChemistry, Graduate School of Science, Nagoya University (Current affiliation),
3JSPS Postdoctoral Fellow
10:45-11:00

Oral Presentations 1O-06 Phase
Chair:Transitions
intheAssemblyof
Trifluoromethylated G-quadruplex RNA by shorter CGG
Trinucleotide Repeats

Hiroshi Abe

Shiyu Wang, Yan Xu*Nagoya Univ.

Division of Chemistry, Department of Medical Sciences, Faculty of Medicine,
University of Miyazaki

1O-07 Small molecule targeting UGGAA pentanucleotide
repeat alleviates disease phenotype in spinocerebellar
ataxia type 31

11:00-11:15

Tomonori Shibata1, Konami Nagano2, Morio Ueyama3, Kensuke
Ninomiya4, Tetsuro Hirose4, Yoshitaka Nagai3, Kinya Ishikawa5, Gota
Kawai2, Kazuhiko Nakatani1*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute ofScientific and Industrial Research), Osaka University, 2Department of Life andEnvironmental Sciences, Faculty of Engineering, Chiba Institute of Technology,
3
Department of Neurology, Kindai University Faculty of Medicine, 4Graduate
School of Frontier Biosciences, Osaka University, 5Center for Personalized
Medicine for Healthy Aging, Tokyo Medical and Dental University
11:15-11:25

Break11:25-12:10

Invited Lecture 1

IL-01

Chair:A Structure-based Approach to RNA-targeted SmallMolecules

Kazuhiko Nakatani

Jennifer C Petter*Arrakis Therapeutics

Osaka Univ.
12:10-13:30

Lunch Break

13:30-15:00

Poster Presentation 1P01-1P58

15:00-15:15

13:30-14:15

Odd Number

14:15-15:00

Even Number

Break15:15-16:00

Invited Lecture 2

Structural Studies of DNA Function in Nucleosomes

Chair:

Hitoshi Kurumizaka1*

Shigenori Iwai

1

Osaka Univ.
16:00-16:15

IL-02

Laboratory of Chromatin Structure and Function, Institute for Quantitative

Biosciences, The University of Tokyo

Oral Presentations 1O-08 Efficient and site-specific chain elongation on a porous

glass sheet in a photolithographic flow system

Chair:
Takehiko Wada
Tohoku Univ.

Yu Ito,1,2 Koichiro Miyauchi,1,2 Yu Miyazaki,1 Saaya Akazawa,1 Akihiro
Ohkubo1,2
1Department of Life Science and Technology, Tokyo Institute of Technology,CREST, Japan Science and Technology Agency (JST)2

1O-09 Chemically modified PCR primer aiming accurate andefficient DNA assembly

16:15-16:30

Fumitaka Hashiya,1 Kaoru Onda,2 Kohei Nomura,2 Gao Yiuno,2Hirotaka Murase,2 Kosuke Nakamoto,2 Masahito Inagaki,2 Haruka
Hiraoka,2 Naoko Abe,2 Yasuaki Kimura,2 Natsuhisa Oka,3,4 GoroTerai,5 Kiyoshi Asai,5 Hiroshi Abe1,2,6,7*
1

Research Center for Material Science, Nagoya University, 2Graduate Schoolof Science, Nagoya University, 3Department of Chemistry and BiomolecularScience, Gifu University, 4Institute for Glyco-core Research (iGCORE), Gifu
University, 5Department of Computational Biology and Medical Sciences,
University of Tokyo, 6CREST, Japan Science and Technology Agency, 7Institutefor Glyco-core Research (iGCORE), Nagoya University

1O-10 Acceleration of DNA hybridization chain reaction bycationic copolymer under physiologically relevant
conditions

16:30-16:45

Jun Wang,1 Naohiko Shimada,1 Atsushi Maruyama1,*
1

Department of Life Science and Technology, Tokyo Institute of Technology

16:45-17:00

Oral Presentations 1O-11 Exploring the Dynamics of Nucleic Acids at the SingleChair:

Molecule Level Using Triplet-Triplet Energy Transfer
Kinetics

Masayuki Fujii

Jie Xu,1 Atsushi Maruyama,2 Mamoru Fujitsuka,1 Kiyohiko Kawai1,*

Kindai Univ.

1SANKEN (The Institute of Scientific and Industrial Research), Osaka
University, 2Department of Life Science and Technology, Tokyo Institute ofTechnology

1O-12 Development of small photosensitizer-oligonucleotide
conjugates for site-specific oxidation of guanosine

17:00-17:15

Takashi Kanamori*, Shota Kaneko, Koji Hamamoto, Wang Chao,Ruoyu Li, Hideya Yuasa*
Department of Life Science and Technology, School of Life Science andTechnology, Tokyo Institute of technology
17:15-17:30

Break17:30-18:15

Invited Lecture 3
Chair:
Hiroyuki Asanuma
Nagoya Univ.

18:15-18:30

18:30-18:45

IL-03 Interlockedengineering

DNAnanostructures

formolecular

Michael Famulok,1,2* Mathias Centola,1,2 Yinzhou Ma1, Marko Škugor1,Ze Yu1, Michael W. Haydell1, Julián Valero3
1

Chemical Biology and Medicinal Chemistry Unit, Life and Medical Sciences(LIMES) Institute, University of Bonn, 2Max-Planck-Fellowship Group ChemicalBiology, Center of Advanced European Studies and Research, 3Interdisciplinary
Nanoscience Center - INANO-MBG, iNANO-huset

Oral Presentations 1O-13 Enzyme Cascade Reactions on a DNA Scaffold withShape Transformation

Chair:Peng Lin,1 Huyen Dinh,1 Eiji Nakata,1 Takashi Morii1,*Atsushi Maruyama

1Tokyo Institute ofTechnology

Institute of Advanced Energy, Kyoto University

1O-14 Aptameric enzyme subunit enhances the peroxidase
activity of myoglobin against luminol
Kaori Tsukakoshi,1 Yasuko Yamagishi1, Mana Kanazashi2, Kenta
Nakama1, Daiki Oshikawa1, Nasa Savory1, Akimasa Matsugami3,Fumiaki Hayashi3, Jinhee Lee4, Taiki Saito1, Koji Sode4, Kanjana
Khunathai2, Hitoshi Kuno2, Kazunori Ikebukuro1,*
1

Department of Biotechnology and Life Science, Tokyo University of Agriculture
and Technology, 2DENSO CORPORATION, 3NMR Science and Development
Division, RIKEN SPring-8 Center, 4Joint Department of BiomedicalEngineering, University of North Carolina at Chapel Hill and North Carolina
State University
18:45-19:00

Oral Presentations 1O-15 Structures and dynamics of oligonucleotides in living
Chair:

human cells evaluated by in-cell NMR

Yan XuYudai Yamaoki,1,2 Tomoki Sakamoto,2 Keiko Kondo,1 Shohei Takami,2Takashi Nagata,1,2 Masato Katahira1,2,*Univ. of Miyazaki

1Institute of Advanced Energy, and 2Graduate School of Energy Science, Kyoto
University

1O-16 Membrane Permeable Oligonucleotides' application onmdx myotubes and its nucleus internalization

19:00-19:15

Zhaoma Shu,1 Haruka Hiraoka,1 Bao Tri Le,2 Keiko Masuda,3 Kousuke
Nakamoto,1 Naoko Abe,4 Yasuaki Kimura,4 Yoshihiro Shimizu,3Rakesh N Veedu,2 Hiroshi Abe4,5*1Chemistry Department, Nagoya University, 2Centre for Molecular Medicine andInnovative Therapeutics, Murdoch University, 3RIKEN Center for Biosystems
Dynamics Research, 4Research Center for Materials Science, Nagoya
University, 5CREST, Japan Science and Technology AgencyBreak
19:30

Online Exchange Meeting

Day 3: November 12th
9:30-10:15

Special Lecture 1

SL-01 Study on the development of nucleoside andoligonucleotide drugs based on genomic information

Chair:Yukio Kitade1*

Yoshihito Ueno

1

Department of Applied Chemistry, Faculty of Engineering, Aichi Institute ofTechnology

Gifu Univ.
10:15-10:30

Oral Presentation

2O-17 Ligand stabilization ofsensitivity to S1 nuclease

Chair:

G-quadruplex

increases

Masayuki Tera,1,* Ryo Ishikawa,1 Mizuho Yasuda,1 Shogo Sasaki,1Yue Ma,1 Kazuo Nagasawa1

Toshihiro Ihara1Department of Biotechnology and Life Sciences, Tokyo University ofAgriculture and Technology

Kumamoto Univ.

2O-18 Chemical modulation of DNA replication by topologydependent ligand binding on guanine quadruplexes

10:30-10:45

Shuntaro Takahashi,1 Anita Kotar,2 Hisae Tateishi-Karimata,1 Sudipta
Bhowmik,3 Zi-Fu Wang,4 Ta-Chau Chang,4 Shinobu Sato,5 ShigeoriTakenaka,5 Janez Plavec,2 Naoki Sugimoto1,6,*1

Frontier Institute for Biomolecular Engineering Research (FIBER), Konan
University, 2Slovenian NMR center, National Institute of Chemistry, SI-1000
Ljubljana, Slovenia Department of Applied Chemistry, 3University of Calcutta,
4Institute of Atomic and Molecular Sciences, Academia Sinica, 5Kyushu Instituteof Technology, 6Graduate School of Frontiers of Innovative Research in Scienceand Technology (FIRST), Konan University
10:45-11:00

Oral Presentation

2O-19 G-quadruplex binding of cyclic naphthalene diimide andtheir inhibition ability in cancer cell growth

Chair:

Shinobu Sato,1
Takenaka1,*Daisuke Miyoshi

HikaruFukida,2

HiroshiTakeuchi,2Shigeori

1

Department of Applied Chemistry, Kyushu Institute of Technology, 2Departmentof Health Promotion, Kyushu Dental University

Konan Univ.

2O-20 Thermodynamic Properties of the Binding between
Antiparallel Triplex Nucleic Acids and Budding Yeast
Triplex Nucleic Acid Binding Protein

11:00-11:15

Maiko Shinmura,1 Momono Kamegai,1 Kei Hirabayashi,1 Hidetaka
Torigoe1,*1Department of Applied Chemistry, Faculty of Science, Tokyo University ofScience
11:15-11:25

Break

11:25-12:10

Invited Lecture 4
Chair:

IL-04 Antisense oligonucleotide-mediated splice modulationof epidermal growth factor receptor (EGFR) in cancer
cells

Satoshi Obika

Rakesh N. Veedu1,2,* Akilandeswari Balachandran1

Osaka Univ.

1

Centre for Molecular Medicine and Innovative Therapeutics, Murdoch
University, 2Perron Institute for Neurological and Translational Science

12:10-13:30

Lunch Break

13:30-15:00

Poster Presentation 2P59-2P117

15:00-15:15

13:30-14:15

Odd Number

14:15-15:00

Even NumberBreak15:15-15:30

15:30-15:45

Oral Presentation

2O-21 Small molecule–PNA oligomer conjugates for rRNA Asite at neutral pH for FID assays

Chair:

En Ting Tabitha, Lee,1 Yusuke Sato,1,* Seiichi Nishizawa1,*Kazunori Ikebukuro

1

Tokyo Univ. ofAgriculture andTechnology

Department of Chemistry, Tohoku University

2O-22 Detection of MicroRNAs with Similar Sequences Using
Reverse-Transcription Hairpin-Probe Polymerase Chain
ReactionFumie Takei,1,* Misaki Akiyama,1 Minoru Dateki1
1

Faculty of Medicine, National Defense Medical College (NDMC)

15:45-16:00

Oral Presentation
Chair:

2O-23 Novel Design Strategy of DNA-Artificial Nucleic Acid
Chimera Toward Enhancement of Target RNA Cleavage
Activities: Application for COVID-19 Therapeutics
Masahito Inagaki,1,3 Nozomu Ishiwata,1 Ryota Azuma,1 Masaki
Nishijima,1 Hironori Hayashi,2 Yasuyuki Araki,1 Eiichi Kodama,2Takehiko Wada1,*Fumi Nagatsugi
Tohoku Univ.

1Institute of Multidisciplinary Research for Advanced Materials (MRAM), Tohoku
University, 2International Research Institute of Disaster Science (IRDeS),Tohoku University, 3Grad. School Science, Nagoya University

2O-24 Nonenzymatic polymerase-like elongation of acyclic Lthreoninol nucleic acid via chemical ligation

16:00-16:15

Keiji Murayama,* Hikari Okita, Hiroyuki Asanuma*
Graduate School of Engineering, Nagoya University

2O-25 Transmission of the genetic information from 4'thioDNA to 4'-thioRNA to protein

16:15-16:30

Noriko Saito-Tarashima, Ayako Matsuo, Noriaki Minakawa*
Graduate School of Pharmaceutical Science, Tokushima University
16:30-16:40

Break16:40-17:25

Invited Lecture 5
Chair:

IL-05 Pyrrole–Imidazole Polyamides as Artificial GeneticSwitches

Kazuhiko Nakatani
Osaka Univ.
17:25-17:35

Break

17:35-Closing Remarks
JSNAC General Meeting

Hiroshi Sugiyama1,2*1

Department of Chemistry, Graduate School of Science, Kyoto University,
Institute for Integrated Cell-Material Science (WPI-iCeMS), Kyoto University2