Other issues to be urgently addressed

Title of Research:
13_PT05-01-2

Development and practical verification of novel comprehensive
monitoring system for multiple contamination of environemntal
pllutants in Mekong River basin
Principal Investigator:
Kazumasa Hirata, PhD (Professor, Osaka University, Pharmaceutical Sciences; 1-6 Yamadaoka,Suita, Osaka 565-0871, Japan)(tel) +81-06-6879-8238, (e-mail) hirata@phs.osaka-u.ac.jp
Collaborators:
Kazuo Harada, PhD (Associate Professor, Osaka University, Pharmaceutical Sciences; 1-6Yamadaoka, Suita, Osaka 565-0871, Japan); Hideyuki Matsuura, PhD (Assistant Professor,Osaka University, Pharmaceutical Sciences; same as above); Yoshinori Sumimura (AssociateProfessor, Osaka University, Global Collaboration Center; 2-7 Yamadaoka, Suita, Osaka565-0871, Japan); Nguyen Quang Trung (Institute of Environmental Technology, Department ofEnvironmental Toxic Analysis; 18 Hoang Quoc Viet Rd., Cau Giay Dist. Hanoi); Misa Muraoka(Specially Appointed Assistant Professor [Full time], Osaka University, Pharmaceutical Sciences;same as above); Tran Thi My Duyen (Lecturer, Can Tho University, College of Aquaculture andFisheries, Department of Aquatic Pathogen; Campus II, 3/2 St., Xuan Khanh Ward, Ninh Kieu Dist.,
Can Tho city, Vietnam.: *Current title: ph.D. student, Osaka University, Pharmaceutical Sciences;same as above); Jun-ichi Nishikawa, PhD (Professor, Mukogawa Women’s University, School of
Pharmacy and Pharmaceutical Sciences; 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179,Japan); Taku Yamashita (Associate Professor, Mukogawa Women’s University, School of
Pharmacy and Pharmaceutical Sciences; same as above)
Summary of Research:Due to the rapid industrialization and population concentration, serious environmental pollution
has been caused by multiple contaminations of pollutants, such as agricultural chemicals,endocrine disruptors, heavy metals, and antibiotics for the international river basin of Southeast
Asia, like Mekong River basin. These environmental pollutions lead to the potential for serious
health damage in ASEAN countries and for high-cost and careful inspection for imported foodsfrom the corresponding area in Japan. To avoid these risks, it is important to construct amonitoring system of food and environmental samples for multiple contaminations ofenvironmental pollutants. The aim of our project is to develop a novel comprehensive monitoring
system for multiple contaminations as an appropriate technology for ASEAN countries. For thispurpose, we plan to tackle the following topics; 1. Gathering of information and investigation ofsituation of pollution in Mekong River basin, 2. Development of bioassay system for detecting fourgroup pollutants (agricultural chemicals, endocrine disruptors, heavy metals, and antibiotics), 3.
Verification of the validity and conformity of bioassay for preliminary analysis applicable to MekongRiver basin and ASEAN countries, 4. Improvement and establishment of the bioassay system, 5.
Investigation on how appropriate for ASEAN countries the bioassay system is. In the present term,
we have tackled a construction of biosensors for sulfonamides and antibiotics that inhibit bacterial
protein synthesis. We proposed a new principle for each biosensor and performed
proof-of-concept experiments.
Timeline:
March 1, 2015Topics:
The New LRI Research Meeting (Tokyo, August 2015; Poster presentation)
Publications:21