A３

KU VISION PITCH 2022

研究実施・計画書

応募者⽒名 / Applicant Name

Research Execution / Plan Form

Laras Putri WIGATIA６KU VISION PITCH 2022

研究実施・計画書

Research Execution / Plan Form

カブトガニが人類を細菌汚染から救う ～世界一の細菌検出薬開発を目指して～〇 細菌はヒトの血液に入ると重篤なショックを起こす（緊急性の高い治療になる）。
カブトガニ〇 カブトガニ体液は極めて微量の細菌に反応体液して瞬時に凝固する性質がある（左図）。この性質を生かし、カブトガニ体液は、国の法律（日本薬局方）で、ワクチンなどの医薬品や医療器具の細菌汚染検査に利用されている。
細菌混入
二億年前から姿を変えない（グラム陰性菌）〇 カブトガニは絶滅危惧種で、今後、天然資「生きた化石？」源が枯渇しかねない。
（独自の進化が明らかにされている！） 凝固する！

カブトガニ＜これまでの研究＞＜今後の研究（製薬企業と連携して推進する）＞〇 ヒトの培養細胞を用いて、 〇 瞬時に凝固するカブトガニ体液の成分に注目！カブトガニ体液は凝固に必要な因子（タンパ
生物種にしては豊富な二価金属イオン（Mg２+, Ca2+）を含む。
ク質）の合成に成功！
→二価金属イオンの添加によって合成した因子の機能が向上した！
→カブトガニから体液を採〇 AI（人工知能） によるタンパク質分子の立体構造取する必要がない！
（形）予測ソフト（AlphaFold）を利用！
〇 合成した因子の高機能化→AI による非常に精度の高い分子の形の予測を利用して、に成功！
因子の高機能化に必要な改造を計画する！
→高感度な細菌検出薬に応〇 カブトガニの研究者は世界でもとても少ないため、カブトガニ以用可能！
外の生物種（ヒト、ハエ、魚など）で似た因子を探し、形や機能を【発表論文（国際誌・査読有）】・Yamashita, K. et al., J Biol Chem. 比較して、 応用できるアイディアを探し出す！
2020 日本比較免疫学会・古田優秀論文賞（九大プレスリリース有）・Yamashita, K. et al., J Biochem.
2021 （九大プレスリリース有）〇 多様な生物の基礎研究や情報科学と連携する点が極めて独創的！
〇 高感度な細菌検出薬の開発は、世界中の医療に貢献するイノベーション創出につながる！さらに、カブトガニの保全にも役立つ！

応募者氏名 / Applicant Name

山下啓介

A９

KU VISION PITCH 2022

Research Execution / Plan Form

研究実施・計画書

胎児期は脳神経幹細胞から神経細胞が絶えず産み出され脳が形作られる⼤事な時期である

・難聴・⽩内障 (⾵疹ウイルス）・⽔頭症 (ジカウイルス）・発達遅延 (インフルエンザウイルス）

⺟⼦感染により胎児期の脳に細菌が感染するとhttps://www.babycenter.com

産まれてくる⼦供に重篤な障害が・・・

胎児脳の細菌感染に有効な治療法は限られる、、

そこで、“アキリン”は胎児の脳を細菌感染から守るバリアとして働く (研究タイトル)ことを⾒出した
アキリン(Akhirin）とは・・
アキリンは本研究室が同定した分⼦である。アキリンは脳の発達期に神経幹細胞に隣接するように発現し（下図）、神経幹細胞の増殖を制御し、脳の形成に関与する。脳の形成が完了するとアキリンの発現も消失する。

アキリンの発現

胎児の脳

②①
I

https://sites.duke.edu/apep

I

細菌

II

アキリン

③II

① 脳内に細菌が感染するとアキリンは切断をうける② 遊離した【I】は細菌に直接結合し、細菌を隔離し細菌感染拡⼤を防ぐ③ 【II】は炎症を抑える免疫反応を刺激する

アキリンは創薬事業への発展性がある
・アキリンは細菌感染後の炎症抑制剤として応⽤可能→細菌感染後にアキリンの過剰投与で感染後の炎症や後遺症が緩和されることが期待・アキリンが発現している他の組織にも応⽤可能→アキリンは脳だけでなく眼・脊髄・精巣などの組織にも発現する
神経幹細胞の細胞層
胎⽣14.5⽇胚のマウスの脳でアキリンは神経幹細胞の表⾯をバリアするように発現している

COVID-19やサル痘などの感染症から胎児脳の発達を守る妊婦が安⼼して出産を迎えられるような薬剤の開発が期待される
応募者⽒名 / Applicant Name

⼯藤 三希⼦A１１

KU VISION PITCH 2022

研究実施・計画書

Research Execution / Plan Form

Background: Inspection of cargo and imported products at the borders of a country is a crucial issue for any government. There
are lots of problems that make it impossible to inspect all cargo, especially huge containers, arriving at the ports of a country.
Recently, inspection systems based on reconstructing the cosmic-ray muon’s tracks while passing through a material have beenvery promising to address almost all issues regarding inspection, especially nuclear materials, which can be detected in thissystem after about 2 minutes of inspection. Muons are particles like electrons but with a mass of 207 times greater than that.
These particles are continuously produced in the upper layer of the atmosphere and provide a free, hazardless, and worldwide
available source. In the inspection systems, the position and direction of muons before the inspection area and after that arerecorded, and based on the detected changes, the materials in the region of interest are identified. We found one issue in thecurrent systems that is using some magnets in the inspection area might led to a wrong detection in the system.

Objectives and method: The objective of this research is to propose an essential upgrade to the inspection systems based on
cosmic-ray muons by adding a known magnetic field to identify muon charges and also two more detection layers.
Expected results and Research plan: In the first step, simulations will be performed to prove the bug in the inspection systems,and based on that, we are going to design and build our prototype inspection system on a small scale and then propose oursystem for inspection at borders. A new analysis method is required, and it will be developed by the authors. We will add afeature to the system that can identify if there is a magnet in the inspection area or not, and if so, a detailed inspection isrequired.
Impact on society: Radiation hazards to society are one important concern. It is not only harmful to the people present insociety, but it will also harm the next generation by causing mutations. Also, as the target of muon-based inspection systems isto detect any material that is defined as forbidden materials by the government, the bug in the system might affect the economyof the country, and people’s jobs and income might be influenced by forbidden imported goods.

Commercialization: Some big projects in the field of using cosmic-ray muons for inspection purposes are sponsored by different
countries worldwide, and recently some companies have been established to build and sell these inspection systems. We
believe that with the support of Japanese companies like Toshiba and Mitsubishi Electric that have already expressed theirinterest in these systems, we can build our own inspection system and also export the required technology to other countries toupgrade their current working systems.

応募者氏名 / Applicant Name

BASIRI HAMID

A２１KU VISION PITCH 2022

研究実施・計画書

Research Execution / Plan Form

Title: Automatic reconstruction of semantic 3-Dimensional models of existing buildings using laser scan

Importance and Impact to society
Concept note
• This research deals with reconstruction of as-built • Manual reconstruction of 3D model of a single
building normally takes up 1 to 3months butstatus of existing buildings using point cloudusing laser scanning it can potentially takegenerated from laser scanners.
about 3 to 7days only.
• Study aims to produce a novel approach using• Result of this research will accelerate rapid
correlation of geometrical positioning andrenovation of large stock of existing old andconnectivity of generic building elements in a point
defective buildings which often lack CAD
cloud.
drawings and/or 3D-BIM.
• The correlation can support construction of• Also, due to speedy reconstruction of 3D-BIM
algorithms for automatic recognition andof existing buildings, developers can opt forsegmentation of individual structural elements,
renovation instead of construction of new
followed-up with automatic conversion intobuildings which can avoid for expensive
Building Information Model (BIM).
demolitions and carbon emission by conserving
natural resources.
Commercialization and implementation plans• This research is based on algorithms which can be fixed in a computer software.
• It is primarily a point cloud processing software which can be applied in two packages:
 Downloadable software in one time payment and install on a computer; Cloud-based software on a plan subscription.
• Registration of patent and copyrights for the software• Enter into exclusive agreement with prominent companies producing laser scanners and BIM
software in order to provide an optimum data integration.
応募者氏名 / Applicant NameNTIYAKUNZE, Joram

A２２

KU VISION PITCH 2022

研究実施・計画書

応募者氏名 / Applicant Name

Research Execution / Plan Form

北島千朔 / Kitajima Chisaki