Kosuke Dodo
Senior Research Scientist
Synthetic Organic Chemistry Laboratory, RIKEN
2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan
Phone: +81 48 467 4071
E-mail: dodo@riken.jp
Education:
1995-1999
1999-2001
2001-2004

Faculty of Pharmaceutical Sciences, The University of Tokyo (BS)Graduate School of Pharmaceutical Sciences, The University of Tokyo (MS)
Graduate School of Engineering, Tohoku University (Ph.D.)

Professional Career:
2004-2007
Special Postdoctral Researcher; RIKEN
2007-2008
Assistant Professor; The Institute of Molecular and Cellular Biosciences,
The University of Tokyo
2008-2013
Research Scientist; Synthetic Organic Chemistry Laboratory, RIKEN
2008-2013
Group Leader; ERATO Sodeoka Live Cell Chemistry Project
2014-present Senior Research Scientist; Synthetic Organic Chemistry Laboratory, RIKEN CPR
2015-present Senior Research Scientist; Catalysis and Integrated Research Group, RIKEN CSRS
Research Field
Chemical Biology, Medicinal Chemistry, Synthetic Organic Chemistry, Biological Chemistry
Research Interests
1) Development and mechanistic study of cell death inhibitors & inducers2) Raman imaging for visualization of small molecules
3) Chemical methodologies for identification of binding proteins & sites of bioactive compounds
Selected Publications
1) Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion
InjuryKosuke Dodo, Tadashi Shimizu, Jun Sasamori, Kazuyuki Aihara, Naoki Terayama, Shuhei
Nakao, Katsuya Iuchi, Masahiro Takahashi, Mikiko Sodeoka
ACS Med. Chem. Lett. 2018, 9, 182-187.
2) Hyperoxidation of Ether-Linked Phospholipids Accelerates Neutrophil Extracellular Trap
Formation
Satoshi Yotsumoto, Yuito Muroi, Tatsuya Chiba, Rio Ohmura, Maki Yoneyama, Megumi
Magarisawa, Kosuke Dodo, Naoki Terayama, Mikiko Sodeoka, Ryohei Aoyagi, Makoto Arita,Satoko Arakawa, Shigeomi Shimizu, Masato Tanaka
Sci. Rep. 2017, 7 (1), 16026.

3) Specific Fluorescence Labeling of Target Protein by Using Ligand–4-Azidophthalimide
Conjugate
Kosuke Chiba, Miwako Asanuma, Minoru Ishikawa, Yuichi Hashimoto, Kosuke Dodo, Mikiko
Sodeoka, Takao Yamaguchi
Chem. Commun. 2017, 53, 8751-8754.
4) Crystal structural characterization reveals novel
voltage-dependent anion channel 1

oligomeric interactions of humanToshiaki Hosaka, Masateru Okazaki, Tomomi Kimura-Someya, Yoshiko Ishizuka-Katsura,
Kaori Ito, Shigeyuki Yokoyama, Kosuke Dodo, Mikiko Sodeoka, Mikako Shirouzu
Protein Science 2017, 26, 1749-1758.
5) Noncanonical Function of a Small-Molecular Virulence Factor Coronatine against Plant
Immunity: An In Vivo Raman Imaging Approach
Minoru Ueda, Syusuke Egoshi, Kosuke Dodo, Yasuhiro Ishimaru, Hiroyuki Yamakoshi,Takeshi Nakano, Yousuke Takaoka, Shinya Tsukiji, Mikiko Sodeoka
ACS Central Science 2017, 3, 462-472.
6) Alkyne-Tag SERS Screening and Identification of Small-Molecule-Binding Sites in Protein
Jun Ando, Miwako Asanuma, Kosuke Dodo, Hiroyuki Yamakoshi, Satoshi Kawata, Katsumasa
Fujita, Mikiko Sodeoka
J. Am. Chem. Soc. 2016, 138, 13901-13910.
7) Structure-activity relationship study of 3-amino-2-indolyllactam derivatives: Development ofinhibitors of oxidative stress-induced necrosis
Kosuke Dodo, Kenji Hayamizu, Tadashi Shimizu, Mikiko Sodeoka
Chem. Pharm. Bull. 2016, 64, 886-898.
8) VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal
region and the bottom of the pore
Masateru Okazaki, Katsue Kurabayashi, Miwako Asanuma, Yohei Saito, Kosuke Dodo, MikikoSodeoka
Biochim. Biophys. Acta 2015, 1848, 3188-3196.
9) Unique features of chiral palladium enolates derived from β-ketoamide: Structure and catalytic
asymmetric Michael and fluorination reactions
Kenji Hayamizu, Naoki Terayama, Daisuke Hashizume, Kosuke Dodo, and Mikiko Sodeoka
Tetrahedron 2015, 71, 6594-6601.
10) Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized byRaman microscopy
Jun Ando, Masanao Kinoshita, Jin Cui, Hiroyuki Yamakoshi, Kosuke Dodo, Katsumasa Fujita,
Michio Murata, and Mikiko Sodeoka
Proc. Nat. Acad. Sci. 2015, 112, 4558-4563.
11) Structure–activity relationships of benzhydrol derivatives based on 10-acetoxychavicol acetate(ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of theNF-kappaB pathway

Takashi Misawa, Kosuke Dodo, Minoru Ishikawa, Yuichi Hashimoto, Morihiko Sagawa,
Masahiro Kizaki, Hiroshi Aoyama
Bioorg. Med. Chem. 2015, 23, 2241-2246.
12) A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging ofmitochondria
Hiroyuki Yamakoshi, Almar Palonpon, Kosuke Dodo, Jun Ando, Satoshi Kawata, Katsumasa
Fujita, and Mikiko Sodeoka
Bioorg. Med. Chem. Lett. 2015, 25, 664-667.
13) A “Catch-and-Release” Protocol for Alkyne-Tagged Molecules Based on a Resin-Bound Cobalt
Complex for Peptide Enrichment in Aqueous Media
Ayako Miyazaki, Miwako Asanuma, Kosuke Dodo, Hiromichi Egami, and Mikiko Sodeoka
Chem. Eur. J. 2014, 20, 8116-8128.
14) Turn-ON fluorescent affinity labeling using a small bifunctional O-nitrobenzoxadiazole unit
Takao Yamaguchi, Miwako Asanuma, Shuichi Nakanishi, Yohei Saito, Masateru Okazaki,Kosuke Dodo and Mikiko Sodeoka
Chem. Sci. 2014, 5, 1021-1029.
15) Simultaneous
imagingof
protonatedanddeprotonatedp-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

carbonylcyanide

Hiroyuki Yamakoshi, Almar F Palonpon, Kosuke Dodo, Jun Ando, Satoshi Kawata, Katsumasa
Fujita, and Mikiko Sodeoka
Chem. Comm. 2014, 50, 1341-1343.
16) Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9ainhibitors: Reducing cytotoxicity by structural simplification
Shinya Fujishiro, Kosuke Dodo, Eriko Iwasa, Yuou Teng, Yoshihiro Sohtome, Yoshitaka
Hamashima, Akihiro Ito, Minoru Yoshida, and Mikiko Sodeoka
Bioorg. Med. Chem. Lett. 2013, 23, 733-736.
17) Alkyne-tag Raman imaging for visualization of mobile small molecules in live cells
Hiroyuki Yamakoshi, Kosuke Dodo, Almar Flotildes Palonpon, Jun Ando, Katsumasa Fujita,
Satoshi Kawata, and Mikiko Sodeoka
J. Am. Chem. Soc. 2012, 134, 20681-20689.
18) Catch & release of alkyne-tagged molecules in water by polymer-supported cobalt complex
Hiromichi Egami, Shinji Kamisuki, Kosuke Dodo, Miwako Asanuma, Yoshitaka Hamashima,and Mikiko Sodeoka
Org. Biomol. Chem. 2011, 9, 7667-7670.
19) Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy
Hiroyuki Yamakoshi, Kosuke Dodo, Masaya Okada, Jun Ando, Almar Palonpon, Katsumasa
Fujita, Satoshi Kawata, and Mikiko Sodeoka
J. Am. Chem. Soc. 2011, 133, 6102–6105.
20) Development of selective inhibitors of necrosis
Mikiko Sodeoka and Kosuke Dodo

Chem. Rec., 2010, 10, 308-314.
21) Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity throughcaspase-8/caspase-3 activation
Yuou Teng, Katsuya Iuchi, Eriko Iwasa, Shinya Fujishiro, Yoshitaka Hamashima, Kosuke
Dodo, and Mikiko Sodeoka
Bioorg. Med. Chem. Lett., 2010, 20, 5085-5088.
22) Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives
related to (-)-epigallocatechin gallate
Kosuke Dodo, Taro Minato, Tomomi Noguchi-Yachide, Masami Suganuma, and Yuichi
HashimotoBioorg. Med. Chem., 2008, 16, 7975-7982.
23) Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide
derivatives
Kosuke Dodo, Miho Katoh, Tadashi Shimizu, Masahiro Takahashi, and Mikiko Sodeoka
Bioorg. Med. Chem. Lett., 2005, 15, 3114-3118.
Honors
2012 Research Project Award, The Society of Synthetic Organic Chemistry, Japan2018 Konica Minolta Imaging Science Encouragement Award, Konica Minolta Science andTechnology Foundation, Japan