by Sabinsa

One Blend. Triple Action.
Clinically Studied Weight
Management Formula
LeanGard® | © 2010 Sabinsa Corporation 1

Synergy and bioavailability: two important aspects of a successful weight loss
program.
LeanGard® formula benefits from synergy of four botanical compounds: hydroxycitric acid (HCA), garcinol (bothcompounds extracted from rinds ofGarcinia gambogia), diterpene forskolin(Coleus forskohlii root extract) and alkaloid piperine (Piper nigrum fruits extract).
The potential of HCA, a compound derived from rind of Garcinia gambogiafruit, as a weight lowering compoundhas been recognized since the 1970's.
However, clinical studies conductedwith this compound provided contradictory results, most likely due to HCA being poorly absorbed and bioavailable
inside of the body fat producing cells toinhibit the target enzyme, citrate lyase.
This critical issue of the HCA absorption
and bioavailability in a weigh management has been addressed in LeanGard
by combining HCA with garcinol (polyisoprenylated benzophenone). Garcinol,
like HCA, is isolated from Garcinia sp.
fruit rind, and has been studied for its
anti-oxidant, anti-inflammatory andcancer preventive properties. Garcinolalso increases levels of liver detox enzymes, like glutathione S-transferase orquinone reductase activities, whichhelps normalize metabolism and remove metabolic toxins that hamper
weight management benefits.
LeanGard biological mechanism further
benefits from addition of diterpene
froskolin, a compound derived fromroots of Coleus forskohlii plant, which

uniquely regulates body composition byenhancing adenylate cyclase and cAMP
cellular levels, increasing lean bodymass and decreasing content of body fat.
Increased lean body mass up-regulates
body metabolism and helps mitigate
body weight gain, as well as maintaining
the accomplished weight reduction in
the long-run, i.e. prevention of so-called
yo-yo effect.
It has been recognized recently that diminished lean body mass slows down
body metabolism and results in difficulties in maintaining an appropriate andhealthy body composition and weight.
Thus, synergistic components of LeanGard provide a sensible weight management approach to reduce bodyweight to acceptable levels by restoring
the optimal proportions of fat to leanbody mass. By maintaining or increasinglean body mass while simultaneously
reducing body fat, the weight loss regimen would serve the general purpose of
improving the overall health of the individual. Lean body mass can simply bedescribed as total body weight minus fat
and it is inversely correlated with morbidity and mortality rates.
LeanGard formula has an additional mechanism to secure gastrointestinal absorption and ultimately bioavailability of
all above discussed ingredients by including in its composition 5mg of 95%
pure alkaloid piperine. Piperine, a pungent compound extracted from blackpepper fruits is known to assist absorption of variety of nutrients and also to
improve diminished nutrient absorption
which typically occurs with aging. In fact,LeanGard® | © 2010 Sabinsa Corporation2

the efficacy of many weight-loss nutriceuticals is known to be diminished in
middle-aged and elderly population.
The therapeutic effects of the individualcomponents of LeanGard evaluated in
the preclinical and human studies include a reduction in total body weightand body mass index, a reduction inbody fat, an increase in lean body massand content of body water, and a reduction in perceived appetite level while
increasing energy levels. The unique
combination of LeanGrad ingredientsresults in enhancement of the biologicalactivity of the weight loss components
and also in the antioxidant and antiinflammatory properties of garcinol.
LeanGard is a total formula for securing
your health.

LeanGard is a combination of these patented ingredients:

LeanGard® | © 2010 Sabinsa Corporation3