List of Poster Presentations on Day 2 (November 11 (Thu))
Poster Presentations

1P-01

Odd Numbers:

November 11 (Thu.)

13:30 – 14:15

Even Numbers:

November 11 (Thu.)

14:15 – 15:00

Synthesis of an amide-linked dinucleotide containing a 3', 4'-bridged nucleic acidand duplex-forming ability of their modified oligonucleotides
Taiki Akino,1 Takashi Osawa,1 Satoshi Obika1,*
1

Graduate School of Pharmaceutical Sciences, Osaka University

1P-02

Synthesis and evaluation of C-nucleotide derivatives
Ryo Miyahara, Yosuke Taniguchi*
Graduate School of Pharmaceutical Sciences, Kyushu University

1P-03

Solid-phase oligonucleotide synthesis
bicyclo[2.2.2]octane-2.3-diol skeleton

using

a

universal

linkerwith

Kazuki Yamamoto,1 Yasufumi Fuchi,1 Yuta Ito,1 Yoshiyuki Hari1*
1

Faculty of Pharmaceutical Sciences, Tokushima Bunri University

1P-04

Development of aminonebularine derivatives for the recognition of duplex DNA
including a 5-methyl CG base pair in an antiparallel triplex DNA
Ryotaro Notomi1, Lei Wang1, Shigeki Sasaki2, Yosuke Taniguchi1*
1

Graduate School of pharmaceutical Science, Kyushu University, 2Faculty of Pharmaceutical Science, Nagasaki
International University

1P-05

Synthesis of N-β-enaminocarbonyl 2-oxazolidinones through ring transformation
reactions of uracils
Yoshiaki Kitamura,1,2,* Yuto Ohshima,2 Yuki Nagaya,3 Masato Ikeda1,2,3,4
1

Faculty of Engineering, Gifu University, 2Graduate School of Natural Science and Technology, Gifu University,
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 4Institute for Glycocore Research (iGCORE)
3

1P-06

Synthesis and Evaluation of (S)-5'-C-Aminopropyl and (S)-5'-C-Aminopropyl-2'arabinofluoro-modified DNAs
Yujun Zhou,1 Ryohei Kajino,2 Yoshihito Ueno1,2,3,4*
1

Graduate School of Natural Science and Technology, Gifu University, 2United Graduate School of Agricultural
Science, Gifu University, 3Faculty of Applied Biological Sciences, Gifu University, 4Center for Highly Advanced
Integration of Nano and Life Sciences (G-CHAIN), Gifu University

1P-07

Synthesis of tetraphosphate nucleoside analogues for polymerase substrate
Mayu Nakamura,1 Masahito Inagaki,1 Hirotaka Murase,1 Shunichi Kato,1 Shogo Hasegawa,1 Fumitaka
Hashiya,2 Yasuaki Kimura,1 Hiroshi Abe1,3,4,*
1

Graduate School of Science, Nagoya University, 2Research Center for Material Science, 3CREST, Japan Scienceand Technology Agency, 4Institute for Glyco-core Research (iGCORE)

1P-08

Synthesis of the exocyclic methylene and methyl analogs of 2ʹ-O,4ʹ-C-ethylenebridged 5-methyluridine and properties of the modified oligonucleotides
Yuta Ito, Kodai Nishida, Norika Tsutsui, Yasufumi Fuchi, Yoshiyuki Hari*
Faculty of Pharmaceutical Sciences, Tokushima Bunri University

1P-09

Synthesis of cyclodextrin modified oligonucleotides
Kaito Suzuki,1 Shoji Fujiwara,1 Akira Ono1,*
1

Department of Materials & Life Chemistry, Faculty of Engineering, Kanagawa University






1P-10

Phosphorylation of nucleotide
phosphorothioate group

analogs

based

on

the

activationof

Shogo Hasegawa,1 Masahito Inagaki,1 Yasuaki Kimura,1 Hiroshi Abe1,2,3,*
1

Graduate School of Science, Nagoya University, 2CREST, Japan Science and Technology Agency, 3Institute for
Glyco-core Research (iGCORE)

1P-11

Synthesis and structure formations of oligonucleotides carrying functionalgroups on pyrimidine bases
Riyo Marui,1 Yuto Nakazawa,1 Minami Matsumoto1, Akira Ono1*
1

Department of Materials & Life Chemistry, Faculty of Engineering, Kanagawa University

1P-12

Development of reduction sensitive protecting groups for oligonucleotide
synthesis
Kenta Hyugaji,1 Yuya Shinkai,1 Tatsuya Kemmoku1, Akira Ono1*
1

Department of Materials & Life Chemistry, Faculty of Engineering, Kanagawa University

1P-13

Synthesis of oligonucleotides with lipophilic residues via 2 ́-O-carbamoylethyl
linker for providing 3 ́-exonuclease resistance and duplex stability
Takahito Tomori,1 Tomohiro Kishimura,1 Koya Uekusa,1 Aya Koyama,1 Yuki Erikawa,1 Yoshiaki
Masaki,1,2 Kohji Seio1,*
1

Department of Life Science and Technology, Tokyo Institute of Technology, 2JST PRESTO

1P-14

Solid-phase synthesis of oligoribonucleoside boranophosphates using the Hboranophosphonate method
Hiromasa Matsuda,1,2 Kazuki Sato,1 Hiroaki Ito1, Tomohito Shuto3, Rintaro Hara1,4, Takeshi Wada1,*
1

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2CMC Production Technology Laboratories,
MTPC Production Technology & Supply Chain Management Division, Mitsubishi Tanabe Pharma Corporation,
3
Graduate School of Frontier Sciences, The University of Tokyo, 4Graduate School of Medical and Dental Sciences,
Tokyo Medical and Dental University

1P-15

Synthesis and Properties of 4'-ThioLNA/BNA
Toshiki Miyazawa,1 Rion Maeda,2 Noriko Saito-Tarashima,1 Yuichi Yoshimura,2 Noriaki Minakawa1*
1

Graduate School of Pharmaceutical Science, Tokushima University, 2Faculty of Pharmaceutical Sciences, Tohoku
Medical and Pharmaceutical University

1P-16

Base recognition
antiparallel TFO

ofN-acetyl-2,6-diaminoquinoline

incorporated

into

an

Gaohong Tu,1 Shuhei Nishizawa,2 Akihiro Ohkubo1*
1

Life Science and Technology, Tokyo Institute of Technology

1P-17

Development of Nucleoside-Based FRET Pair and Incorporation into Nucleosome
Shingo Hirashima1, Soyoung Park2*, Hiroshi Sugiyama1,3*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Department of Genome Informatics,
Immunology Frontier Research Center (iFReC), Osaka University, 3Institute for Integrated Cell Material Science(WPI-iCeMS)

1P-18

Synthesis and Application of a 19F-labeled Fluorescent Nucleoside as a Dualmode Probe for i-Motif DNA
Wen Ann Wee,1 Ji Hye Yum,1 Shingo Hirashima,1 Hiroshi Sugiyama,1,2,* Soyoung Park3,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material
Sciences (WPI-iCeMS), Kyoto University, 3Department of Genome Informatics, Immunology Frontier ResearchCenter (iFReC), Osaka University







1P-19

Development of Molecular Rotor-Type Fluorescent Thymidine Analogue by
Introducing a C–C Double Bond
Tomotaka Kumagai,1 Shingo Hirashima,1 Hiroshi Sugiyama,1,2,* Soyoung Park3,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material
Sciences (WPI-iCeMS), Kyoto University, 3Department of Genome Informatics, Immunology Frontier ResearchCenter (iFReC), Osaka University

1P-20

Covalent-binding aptamer: a new covalent drug modality for control of irreversible
inhibition activity
Yudai Tabuchi,1, 2 Jay Yang,1, 2, 3,* Masumi Taki1*
1

Department of Engineering Science, The University of Electro-Communications, 2University of Wisconsin-Madison,
Department of GI Surgery II, Hokkaido University

3

1P-21

Evaluation of the DNA interstrand cross-linking of novel psoralen-conjugatedtriplex-forming oligonucleotides
Yu Mikame,1 Juki Nakao,1 Tsuyoshi Yamamoto,1 Asako Yamayoshi1*
1

Graduate School of Biomedical Sciences, Nagasaki University

1P-22

Radiation-activated oligodeoxynucleotides possessing thiothymidine unit thatwere tethered with alkyl chain via disulfide bond
Shuhei Sugimoto,1 Tatsuya Nishihara,1 Kazuhito Tanabe1,*
1

College of Science and Engineering, Aoyama Gakuin University

1P-23

Indirect ubiquitination for targeted degradation of the transcription factor
Ryoka Fujita,1 Takafumi Furuhata,1 Yuto Matsumura,1 Tokiha Ozawa,1 and Akimitsu Okamoto1,2,*
1

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 2ResearchCenter for Advanced Science and Technology, The University of Tokyo

1P-24

Chemical synthesis and evaluation of 4'-thiomodified cyclic dinucleotides
Mao Kinoshita, Noriko Saito-Tarashima, Noriaki Minakawa*
Graduate School of Pharmaceutical Science, Tokushima University

1P-25

Next generation nucleic-acid medicine that suppresses gene expression by the
induction of RNA structure
Tomoki Kida,1 Yousuke Katsuda,1,* Takuto Kamura,1 Yusuke Kitamura,1 Masaki Hagihara,2 Shin-ichi
Sato,3 Toshihiro Ihara1
1

Faculty of Advanced Science and Technology, Kumamoto University, 2Faculty of Science and Technology, Hirosaki
University, 3Institute for Chemical Research, Kyoto University

1P-26

Reactivity modulation of reactive OFF-ON type alkylating agents for G-quadruplex
structures
Yutong Chen, Kazumitsu Onizuka, Madoka Eurika Hazemi, Fumi Nagatsugi*
Institute of multidisciplinary research for Advanced Materials, Tohoku University

1P-27

Synthesis of Creation of interstrand cross-linked nucleic acids and theirapplication for miRNA inhibition
Ahmed Mostafa Abdelhady,1,2 Kazumitsu Onizuka,1,2* Yu Hirano,3 Yasuo Komatsu,3 Fumi Nagatsugi1,2*
1

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2Department of Chemistry,
Graduate School of Science, Tohoku University, 3Bioproduction Research Institute, National Institute of Advanced
Industrial Science and Technology (AIST)







1P-28

Hydration parameters in nearest-neighbor model enables stability prediction forcompositionally biased DNA duplexes in molecular crowding conditions
Saptarshi Ghosh,1 Shuntaro Takahashi,1 Naoki Sugimoto1,2,*
1

Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Graduate School of Frontiersof Innovative Research in Science and Technology (FIRST), Konan University

1P-29

SynthesisEnhancing the Stability of 2D DNA Origami by Enzymatic Ligation
Kirankumar Krishnamurthy,1 Arivazhagan Rajendran,1 Eiji Nakata,1 Takashi Morii1,*
1

Institute of Advanced Energy, Kyoto University

1P-30

Development of novel FRET-based oligonucleotide probes for target DNA
detection
Yurino Oku, Shoutoku Koboku, Yoshio Saito*
1

Department of Chemical Biology and Applied Chemistry, College of Engineering, Nihon University

1P-31

Metal Nanoparticles Induced Strand Cleavage of Oligonucleotides for GenomeScale DNA Synthesis
Masahito Inagaki,1 Haruka Hiraoka,1 Mikiya Kase,1 Fumitaka Hashiya,1,2 Naoko Abe,1 Yasuaki Kimura,1Hiroshi Abe1,3,4*
1

Department of Chemistry, Graduate School of Science, Nagoya University, 2Research Center for Materials Science,
Nagoya University; 3JST CREST, 4Institute for Glyco-core Research (iGCORE)

1P-32

Development of DNA/RNA editing with site-specific C->U conversion using
reversible photo-cross-linking
Jun-ichi Mihara, Kanako Ishino, Shigetaka Nakamura, Kenzo Fujimoto*1

School of Advanced Science and Technology, Japan Advanced Institute of Science and technology

1P-33

Regulation of circular RNA biogenesis via nucleic acid binding small molecule incells
Lu Ni,1 Takeshi Yamada,1 Asako Murata,1 Kazuhiko Nakatani,1,*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University

1P-34

Selective uptake of oligodeoxynucleotides into hypoxic cells: molecular designof modified nucleobase that was activated by nitroreductase
Takuto Kikuchi1, Tatsuya Nishihara1, Kazuhito Tanabe1*1Graduate School of science and Engineering, Aoyama Gakuin University

1P-35

Preparation of oligonucleotides carrying thiol groups:Formation and cleavage of
disulfide bonds
Tomoki Mikami,1 Akihiro Funama,1 Akira Ono1*
1

Department of Materials & Life Chemistry, Faculty of Engineering, Kanagawa University

1P-36

Conformational changes of DNA-ligand complexes for selective recognition oftarget cells
Risa Yamada,1 Shuhei Moritani,1 Tatsuya Nishihara,1 Kazuhito Tanabe1,*
1

College of Science and Engineering, Aoyama Gakuin University

1P-37

Design of DNA sequence-specific modular adaptors by tuning the reactivity ofprotein-tag substrate
Zhengxiao Zhang,1 Eiji Nakata,1 Dinh Huyen,1 Masayuki Saimura,1 Kazunari Matsuda,1 Takashi Morii1,*
1

Institute of Advanced Energy, Kyoto University






1P-38

Visualization of Cellular G-quadruplexes using a Novel Fluorescent G-quadruplex
LigandAyano Sasaki,1 Shunsuke Ishida,1 Takayoshi Arai,1 Keisuke Iida1,*
1

Soft Molecular Activation Research Center (SMARC), Chiba Iodine Resource Innovation Center (CIRIC), Molecular
Chirality Research Center (MCRC), and Department of Chemistry, Graduate School of Science, Chiba University

1P-39

Structure-Activity Relationships of Cytotoxic Platinum(II)-Salphen Complexes as
G-Quadruplex Ligands
Natsumi Suzuki,1 Takayoshi Arai,1 Keisuke Iida1,*
1

Soft Molecular Activation Research Center (SMARC), Chiba Iodine Resource Innovation Center (CIRIC), Molecular
Chirality Research Center (MCRC), and Department of Chemistry, Graduate School of Science, Chiba University

1P-40

Synthesis of Reversible Binding of Triplex-forming Oligonucleotides Based on
Metal Complexation of 5-Hydroxyuracil Nucleobases
Keita Mori,1 Kotaro Nishiyama,1 Yusuke Takezawa,1 Mitsuhiko Shionoya1,*
1Department of Chemistry, Graduate School of Science, The University of Tokyo

1P-41

Dimerization of COVID-19 mRNA formed by an unusual topological RNA Gquadruplex
Yi Song, Shiyu Wang, Yan Xu*
1Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki

1P-42

Detection of DNA triplex structures in living human cells by in-cell NMR
Tomoki Sakamoto,1,2 Yudai Yamaoki,1,2 Takashi Nagata,1.2 Masato Katahira1,2,*
1

Institute of Advanced Energy, and 2Graduate School of Energy Science, Kyoto University

1P-43

Structure-based derivatization of berberine to improve its RNA binding affinity
Sagar Satpathi,1 Tamaki Endoh,1 Yutong Chen,2 Saki Matsumoto,1 Tatsuya Ohyama,1 Peter
Podbevšek,3 Janez Plavec,3,4,5 Kazumitsu Onizuka,2 Fumi Nagatsugi,2 Naoki Sugimoto1,6*
1

Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Institute of Multidisciplinary
Research for Advanced Materials, Tohoku University, 3Slovenian NMR Centre, National Institute of Chemistry,
4
EN→FIST Centre of Excellence, 5Faculty of Chemistry and Chemical Technology, University of Ljubljana,
6
Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University

1P-44

N,N’-diheteroaryl guanidine derivatives targeting GGCCCC repeat DNA
Eitaro Murakami,1 Tomonori Shibata,1 Megumi Tomemori,2 Gota Kawai,2 Kazuhiko Nakatani1,*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (the Institute of Science and Industrial Research),
Osaka University, 2Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute ofTechnology

1P-45

Intermediate structure in the binding of naphthyridine dimer to d(CGG) triad
revealed by NMR
Shuhei Sakurabayashi,1,2 Kyoko Furuita,2 Takeshi Yamada,1 Toshimichi Fujiwara,2 Kazuhiko Nakatani1,
and Chojiro Kojima2,3,*
1

Department of Regulatory Bioorganic Chemistry, SANKEN, Osaka University, 2Institute for Protein Research,
Osaka University, 3Graduate School of Engineering Science, Yokohama National University,

1P-46

Interaction between DANP and a DNA hairpin with a C bulge residue
Megumi Tomemori1, Konami Nagano2, Shuhei Sakurabayashi3, Eitaro Murakami3, Kazuhiko Nakatani3,
Gota Kawai1,2,*
1

Department of Life Science, Faculty of Advanced Engineering, Chiba Institute of Technology, 2Department of Lifeand Environmental Sciences, Graduate School of Engineering, Chiba Institute of Technology, 3Department ofRegulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University






1P-47

Interaction between NCD and an RNA hairpin derived from human pre-miR-4469
Ayano Yazaki1, Denaly Cab2, Konami Nagano2, Shuhei Sakurabayashi3, Eitaro Murakami3, Kazuhiko
Nakatani3, Gota Kawai1,2,*
1

Department of Life Science, Faculty of Advanced Engineering, Chiba Institute of Technology, 2Department of Lifeand Environmental Sciences, Graduate School of Engineering, Chiba Institute of Technology, 3Department ofRegulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University

1P-48

SERS-Based detection of intracellular oligonucleotides by using acetylenetagged Hoechst molecules
Hiroki Makanai,1 Tatsuya Nishihara,1 Kazuhito Tanabe1,*
1

College of Science and Engineering, Aoyama Gakuin University

1P-49

Synthesis of benzo[a]pyrene-modified probes for imaging of endogenous mRNAs
with a point mutation
Yu Watari, Kaito Nakatani, Tomonori Waku, Akio Kobori*
Graduate school of science and technology, Kyoto Institute of Technology

1P-50

DNA nanostructure-based fluorescent pH sensor for cellular pH change
Khongorzul Gerelbaatar,1 Eiji Nakata,1 Hisaaki Hirose,2 Shiroh Futaki,2 Takashi Morii1*
1

Institute of Advanced Energy, Kyoto University, 2Institute for Chemical Research, Kyoto University

1P-51

DNA Origami as a Scaffold to Assemble Membrane Proteins on an Artificial
Compartment
Shiwei Zhang,1 Eiji Nakata,1 Takashi Morii1,*
1

Institute of Advanced Energy, Kyoto University

1P-52

Photocontrolled Assembly of DNA origami Nanostructures using Photoswitching
Molecules
Shubham Mishra,1 Soyoung Park,2 Tomoko Emura,1 Kumi Hidaka,1 Ganesh N. Pandian,3 Hiroshi
Sugiyama,1,3,* Masayuki Endo3,4,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Department of Genome Informatics,
Immunology Frontier Research Center (iFReC), Osaka University, 3Institute for Integrated Cell-Material Sciences(WPI-iCeMS), Kyoto University, 4Organization for Research and Development of Innovative Science andTechnology, Kansai University

1P-53

Construction of Reconfigurable DNA Nanolattice Responding to Signal DNAs
Kotaro Watanabe,1 Ibuki Kawamata,1,2 Yuki Suzuki,1,3,* Satoshi Murata1,*
1

Department of Robotics, Graduate School of Engineering, Tohoku University, 2Natural Science Division, Faculty ofCore Research, Ochanomizu University, 3Frontier Research Institute for Interdisciplinary Sciences, Tohoku
University

1P-54

Construction of a RubisCO assembly on 3D DNA scaffold
Hiroaki Konishi,1 Dinh Huyen,2 Eiji Nakata,1,2 Haruyuki Atomi,3 Takashi Morii,1,2,*
1

Graduate School of Energy Science, Kyoto University, 2Institute of Advanced Energy, Kyoto University, 3Graduate
School of Engineering, Kyoto University

1P-55

Construction of Optical Control System for Functional Biomolecules using DNA
Origami Structure
Katsuhiko Abe,1 Ganesh N. Pandian,2 Hiroshi Sugiyama1,2,* Masayuki Endo2, 3,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material

Sciences (WPI-iCeMS), Kyoto University, 3Organization for Research and Development for Innovative Science andTechnology, Kansai University







1P-56

Design of a multifunctional receptor system controlled by DNA aptamers
Hanrui Liu,1 Ryosuke Ueki,1,* Shinsuke Sando1,*
1

Department of Chemistry & Biotechnology, School of Engineering, The University of Tokyo

1P-57

A DNA aptamer with high specificity for fibroblast growth factor receptor 1
Junya Hoshiyama,1 Yuga Okada,1 Yuri Hayata,1 Akihiro Eguchi,1 Ryosuke Ueki,1,* Shinsuke Sando1,*
1

Department of Chemistry & Biotechnology, School of Engineering, The University of Tokyo

1P-58

A novel DNA aptamer targeting growth factor receptor and its characterization
Seojung Cho1, Ayaka Ueki1, Ryosuke Ueki1,*, Shinsuke Sando1,*
1

Department of Chemistry & Biotechnology, School of Engineering, The University of Tokyo

List of Poster Presentations on Day 3 (November 12 (Fri))
Poster Presentations

2P-59

Odd Numbers:

November 12 (Fri.)

13:30 – 14:15

Even Numbers:

November 12 (Fri.)

14:15 – 15:00

G-quadruplex formation in cancer cells with different expression level of ionchannelsHisae Tateishi-Karimata,1 Naoki Sugimoto1,2,*
1

Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Graduate School of Frontiersof Innovative Research in Science and Technology (FIRST), Konan University

2P-60

Application of nearest-neighbor model to the stability prediction of i-motif DNAs
Pallavi Chilka,1 Shuntaro Takahashi,1 Naoki Sugimoto1,2,*
1

Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Graduate School of Frontiersof Innovative Research in Science and Technology (FIRST), Konan University

2P-61

Searching for factors that regulate i-motif structure by using ligand-directed
protein labeling oligonucleotides
Yuki Ban, Yuma Terai, Risa Matsumura, Shigenori Iwai, Junpei Yamamoto*
Graduate School of Engineering Science, Osaka University

2P-62

Triplex-forming peptide nucleic acid inhibits maturation of endogenous miRNA
Tamaki Endoh,1 Nikita Brodyagin,2 Dziyana Hnedzko,2 Eriks Rozners,2 Naoki Sugimoto1,3,*
1

Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Department of Chemistry,
Binghamton University, The State University of New York, 3Graduate School of Frontiers of Innovative Research in
Science and Technology (FIRST), Konan University

2P-63

Photo-cross-linking
oligonucleotides

behaviorsofpsoralen-conjugatedtriplexforming

Juki Nakao1, Honoka Eshima1, Yu Mikame1, Misaki Matsuo1, Tsuyoshi Yamamoto1, Chikara Dohno2,
Takehiko Wada3, Asako Yamayoshi1*
1

Grad. Sch. Biomed. Sci., Nagasaki Univ., 2Inst. of Sci. Indust. Res., Osaka Univ., 3Inst. of Multi-discip. Res. for Adv.
Mater., Tohoku Univ.

2P-64

Enzymatic preparation of fluorescent DNA functionalized with perylenediimide
derivatives
Yuuna Yamamoto, Tadao Takada,* Ami Takata, Mitsunobu Nakamura, Kazushige Yamana
Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo

2P-65

Solid-phase Synthesis of 2’-O-Methyl RNA Containing Amide-linked RNA Modified
with Pyrene at the 2’-Position
Reiko Iwase,1,* Miki Hayakawa,1 Gaku Nakajima,1 Miki Ando,1 Misaki Hashimoto,1 Kenji Ueda,1 Hideuki
Takahashi1
1Department of Life & Health Sciences, Faculty of Life & Environmental Sciences, Teikyo University of Science

2P-66

Evaluation of the effect of G4-forming sequences in genomic RNA of SARS-CoV2 virus on its translation
Hiroyuki Endo,1 Kaori Tsukakoshi,2 Junya Kitamura,2 Masayuki Tera,2 Kazuo Nagasawa,2 Akira
Shiraishi,3 Kazunori Ikebukuro2,*
1

Department of Management of Technology, Graduate School of Engineering, Tokyo University of Agriculture andTechnology, 2Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University ofAgriculture and Technology, 3Bioorganic Research Institute, Suntory Foundation for Life Sciences






2P-67

Characterization of archaeal Endonuclease V
Michihi Hidaka,1 Miyako Shiraishi,1* Shigenori Iwai1*
1Graduate School of Engineering Science, Osaka University

2P-68

Cell-based screening of chemical libraries for small molecules that target SARSCoV-2 frameshifting signal
Risa Anami, Asako Murata, Kazuhiko Nakatani*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University

2P-69

Improved Spinach aptamer with triplex for in vivo pH monitoring
Saki Tamura,1 Kinuko Ueno,2 Kaori Tsukakoshi,2 Kazunori Ikebukuro2*
1

Department of management of technology, Graduate School of Engineering, Tokyo University of Agriculture andTechnology, 2Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University ofAgriculture and Technology

2P-70

Design of bright yellow fluorogenic probes based on benzo[c,d]indole-containing
cyanine dyes for RNA imaging in living cells
Kei higuchi,1 Yusuke Sato,1 Seiichi Nishizawa1,*
1

Department of Chemistry, Graduate School of Science, Tohoku University

2P-71

Computer-aided classification of small molecules targeting CAG-repeat DNA
Qingwen Chen,1 Asako Murata,1 Takeshi Yamada,1 Ayako Sugai,1 Yasuyuki Matsushita,2 Kazuhiko
Nakatani1,*
1

SANKEN, Osaka University, 2Graduate School of Information Science and Technology, Osaka University

2P-72

Effect of Guanine-guanine Mismatch Binding Ligand on Repair Enzymes’
Reactions In Vitro
Anisa Ul’Husna,1 Asako Murata,1 Kazuhiko Nakatani1,*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University

2P-73

Development of Exploration Method and Informatics analysis for small moleculeRNA pairs
Yusuke Takashima,1 Asako Murata,1 Kei Iida,2 Masatoshi Hagiwara3 and Kazuhiko Nakatani1,*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University, 2Medical Research Support Center, Kyoto University Graduate School of Medicine, 3Departmentof Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine

2P-74

Modulation of cytosine deamination catalyzed by Deoxycytidine Deaminase
APOBEC by binding of small molecule to DNA
Luyan Zhang1, Asako Murata1, Kazuhiko Nakatani1,*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University

2P-75

Histidine-DNA Hybrid Catalysts as Laccase-mimicking DNAzymes
Ji Hye Yum,1 Hiroshi Sugiyama,1,2,* Soyoung Park3,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material
Sciences (WPI-iCeMS), Kyoto University, 3Department of Genome Informatics, Immunology Frontier ResearchCenter (iFRec), Osaka University






2P-76

Expansion of polygonal-shaped 2D ribozyme nanostructures to their doubledecker 3D forms through rationally introducing a pillar kissing-loop motif
Md. Dobirul Islam1, Kai Yu2, Kumi Hidaka3, Hiroshi Sugiyama3,4, Masayuki Endo4,5, Shigeyoshi
Matsumura1,2, Yoshiya Ikawa1,2*
1

Graduate School of Innovative Life Science, 2Graduate School of Science and Engineering, University of Toyama,
Graduate School of Science, 4Institute for Integrated Cell-Material Sciences, Kyoto University, 5Organization for
Research & Development of Innovative Science & Technology, Kansai University
3

2P-77

Computational ligand design for DNA/RNA bulge recognition by a combination ofmulti-level layered elongation method and machine learning
Yuuichi Orimoto,1 Keisuke Hisama,2 Kazuhiko Nakatani,3 Yuriko Aoki1,*
1

Department of Material Sciences, Faculty of Engineering Sciences, Kyushu University, 2Department ofInterdisciplinary Engineering Sciences, Chemistry and Materials Science, Interdisciplinary Graduate School ofEngineering Sciences, Kyushu University, 3Department of Regulatory Bioorganic Chemistry, The Institute of
Scientific and Industrial Research

2P-78

Novel structures of non-natural nucleic acid duplexes
Akira Ono,1* Chinatsu Yazawa,1 Takahiro Atsugi1, Jiro Kondo2
1

GraduatDepartment of Materials & Life Chemistry, Faculty of Engineering, Kanagawa University, 2Department ofMaterials and Life Sciences, Faculty of Science and Technology, Sophia University

2P-79

Development of an AND-gate DNAzyme that responds to Cu(II) and Ag(I) ions as
inputsYusuke Takezawa,1 Takahiro Nakama,1 Mitsuhiko Shionoya1,*
1Department of Chemistry, Graduate School of Science, The University of Tokyo

2P-80

Directed evolution of orthogonal RNA–RBP pairs through library-vs-library in vitro
selection
Keisuke Fukunaga,1 Yohei Yokobayashi1,*
1

Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate University(OIST)

2P-81

Effect of multimeric G4 forming aptamer on luminol chemiluminescence catalyzed
by myoglobin
Hyuga Nakamura,1 Kaori Tsukakoshi,1 Kazunori Ikebukuro1*
1

Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture
and Technology

2P-82

Changes in the atomic-level behavior of G-quadruplex under high pressure
conditions
Tatsuya Ohyama,1 Hisae Tateishi-Karimata,1 Shuntaro Takahashi,1 Shigenori Tanaka,2 Naoki
Sugimoto1,3,*
1

Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Graduate School of System
Informatics, Kobe University, 3Graduate School of Frontiers of Innovative Research in Science and Technology(FIRST), Konan University

2P-83

Probing DNA Topology and DNA-Protein Interactions by Using TopologicallyInterlocked DNA Structures
Arivazhagan Rajendran,1 Seojeong Park,2 Eiji Nakata,1 Youngjoo Kwon,2 Takashi Morii1,*
1

Institute of Advanced Energy, Kyoto University, 2College of Pharmacy, Ewha Womans University






2P-84

Fluorescence sensing of influenza A virus RNA promoter by thiazole orange basesurrogate-carrying PNA conjugated with small molecule
Hiromasa Miura, Takaaki Tanabe, Yusuke Sato*, Seiichi Nishizawa*
Department of Chemistry, Graduate School of Science, Tohoku University

2P-85

Identification of small molecules that can bind to the SARS-CoV-2 frameshifting
signal by SPR-based screening of chemical libraries
Hiyori Fujii,1 Asako Murata,1 Kazuhiko Nakatani1,*1Depertment of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University

2P-86

Synthesis of quinoxaline-2,3-dione derivatives and binding properties to DNA andRNA with tandem C-C mismatches
Zilu Xing,1 Tomonori Shibata,1 Kazuhiko Nakatani1,*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University

2P-87

An RNA internal loop of C, U and A/CC motifs specific fluorescence probe ANP77
Bimolendu Das,1 Asako Murata,1 Kazuhiko Nakatani1,*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University

2P-88

A dual fluorescence turn-on probe for simultaneous imaging of double-stranded
DNA and G4 DNA
Takashi Sakamoto1,2,* Zehui Yu,1 Yuto Otani2
1

Systems Engineering, Wakayama University, 2Graduate School of Systems Engineering, Wakayama University

2P-89

Molecular Recognition Mechanism of the Binding between Quadruplex Nucleic
Acids and Budding Yeast Quadruplex Nucleic Acid Binding Protein
Kazuya Nakamura,1 Kei Hirabayashi,1 Hidetaka Torigoe1,*1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science

2P-90

Thermodynamic Properties of the Specific Binding between Metal Ion andMismatched Base Pair under Molecular Crowding Condition
Sumire Nakayama,1 Hayahide Kida,1 Akira Ono,2 Kei Hirabayashi,1 Hidetaka Torigoe1,*1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 2Department of Material & Life
Chemistry, Faculty of Engineering, Kanagawa University

2P-91

Thermodynamic Properties of the Specific Binding between Metal Ion andMismatched Base Pair in a Duplex Containing 2’-O, 4’-C Methylene Bridged
Nucleic Acid
Hayahide Kida,1 Sumire Nakayama,1 Akira Ono,2 Kei Hirabayashi,1 Hidetaka Torigoe1,*1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 2Department of Material & Life
Chemistry, Faculty of Engineering, Kanagawa University

2P-92

Tropylium Derivatives as New Entrants that Sense Quadruplex Structures
Daisuke Hori,1 Ji Hye Yum,1 Hiroshi Sugiyama,1,2,* Soyoung Park3,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material
Sciences (iCeMS), Kyoto University, 3Department of Genome Informatics, Immunology Frontier Research Center(iFReC), Osaka University






2P-93

Inhibition of GLI-mediated Transcription by Cyclic Pyrrole–Imidazole Polyamides
in Glioblastoma
Vinodh J Sahayasheela1, Zutao Yu1,2, Ganesh N. Pandian2*, Toshikazu Bando1, Hiroshi Sugiyama1,2*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material

Science (WPI-iCeMS), Kyoto University

2P-94

Comparative study of ribozyme sequences for RNA circularization
Akane Kiyose, Takumi Kameyama, Junji Kawakami*
FIRST, Konan University

2P-95

qPCR-based Screening Methods for Small Molecules that Modulate Dicermediated pre-miR-182/31/30d Processing
Muhammad Nurrohman Sidiq, Asako Murata, Kazuhiko Nakatani*
1

Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial Research),
Osaka University

2P-96

Detection of CpG methylation in G-quadruplex Forming Sequences
Hijiri Hasegawa1, Ikkei Sasaki2, Kaori Tsukakoshi2, Yue Ma3, Kazuo Nagasawa2, Shusuke Numata4,
Yuuki Inoue1, Yeji Kim1 and Kazunori Ikebukuro2*
1

LG Japan Lab Inc., 2Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo
University of Agriculture and Technology, 3Institute of Global Innovation Research, Tokyo University of Agriculture
and Technology, 4Department of Psychiatry, Graduate School of Biomedical Sciences, Tokushima University

2P-97

Proximity ligation assay combining aptamer with antibody for detection ofamyloid-beta oligomers in brains
Jo Kamada,1 Kaori Tsukakoshi,1* Chihiro Hosoi,1 Takashi Saito,2,3 Takaomi C. Saido,3 Kazunori
Ikebukuro1*
1

Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture
and Technology, 2Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University
Graduate School of Medical Sciences, 3Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science

2P-98

Simultaneous enhancement of hybridization chain reaction (HCR)-DNAzyme
coupling reaction by cationic copolymers
Naoki Yoshida1, Wang Jun1, Naohiko Shimada1, and Atsushi Maruyama1*
1School of Life Science and Technology, Tokyo Institute of Technology

2P-99

Quantitative PCR Discriminating Single Point Mutation Using Chemically Modified
Primers
RyosukeFujita1,YasuoShiohama2,MaikaSonokawa1, MasaakiHisano1, Yojiro Kotake1 and Masayuki
Fujii*1
1

Kindai University, 2University of the Ryukyu

2P-100Synthesis and purification of reduced DNA-silver hybrid nanowires
Natsumi Eguchi,1 Takahiro Atsugi,2 Takenori Dairaku,3 Yoshiyuki Tanaka,4 Akira Ono,2 Jiro Kondo1,*
1

Graduate School of Science and Technology, Sophia University, 2Graduate School of Engineering, Kanagawa
University, 3School of Pharmaceutical Sciences, Ohu University, 4Faculty of Pharmaceutical Sciences, Tokushima
Bunri University

2P-101RNA FISH of 16S rRNA in E. coli using multiple probes containing ultrafast RNA
photo-cross-linker
Zumila Halili,1 Nanami Watanabe,1 Shigetaka Nakamura,1 Kenzo Fujimoto1,*
1

School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology







2P-102Development of highly sensitive genetic analysis method using signal
amplification by dumbbell-shaped molecular beacons
Tomohisa Moriguchi* Ayana Nagai, Noriko Takayama, Kazuo Shinozuka
Division of Molecular Science, Graduate School of Science and Technology, Gunma University

2P-103

Quantification of target nucleotides using ratiometric SERS assays
Kenta Sasaki, Ryo Ota, Tomonori Waku, Akio Kobori*
Graduate school of science and technology, Kyoto Institute of Technology

2P-104

Nanopore decoding with DNA computing-induced structural change formicroRNA pattern recognition
Sotaro Takiguchi and Ryuji Kawano*Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology

2P-105

Effect of multivalent fatty acid conjugation on the activity and membrane
permeability of antisense oligonucleotides
Yuya Tanaka,1 Yurika Tanioku,2 Kotomi Aso,3 Taisuke Nakayama,3 Haruhiko Kamada,3 Takao
Yamaguchi,1,* Satoshi Obika1,3,*
1

Graduate School of Pharmaceutical Sciences, Osaka University, 2School of Pharmaceutical Sciences, Osaka
University, 3National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki

2P-106

Synthesis and evaluation of antisense oligonucleotides multiply conjugated withhexose-type sugar monomers
Yurika Tanioku,1 Yuya Tanaka,2 Yuuya Kasahara,3 Taisuke Nakayama,3 Haruhiko Kamada,3 Takao
Yamaguchi,2,* Satoshi Obika2,3,*
1

School of Pharmaceutical Sciences, Osaka University, 2Graduate School of Pharmaceutical Sciences, Osaka
University, 3National Institutes of Biomedical Innovation, Health and Nutrition

2P-107

Synthesis and in vivo evaluation of 9-aminoethoxy-1,3-diaza-2-oxophenoxazine
conjugated antisense oligonucleotides
Ryohei Yamaji,1 Yuki Kishimoto,1 Akane Fujii,1 Tomoki Matsumura,1 Osamu Nakagawa,1,3 Taisuke
Nakayama,2 Haruhiko Kamada,2 Satoshi Obika1,2,*
1

Graduate School of Pharmaceutical Sciences, Osaka University, 2National Institutes of Biomedical Innovation,
Health and Nutrition, 3Faculty of Pharmaceutical Sciences, Tokushima Bunri University

2P-108Development of novel circulating microRNA-targeting antibody-oligonucleotide
conjugates for lung cancer therapy
Shota Oyama,1 Kuon Kanazawa,1 Aiko Yoshida,2 Yu Mikame,1 Tsuyoshi Yamamoto,1 Yusuke Ohba,2Asako Yamayoshi1,*1Graduate School of Biomedical Sciences, Nagasaki Univ., 2Faculty of Medicine and Graduate School of Medicine,
Hokkaido Univ.,

2P-109Immunostimulatory Activity of DNA Dendrimers
Yusuke Kawamoto,1,* Wen Liu,1 Ji Hye Yum,2 Soyoung Park,2 Hiroshi Sugiyama,2,3 Yuki Takahashi,1
Yoshinobu Takakura1,*
1

Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto

University, 2Department of Chemistry, Graduate School of Science, Kyoto University, 3Institute for Integrated CellMaterial Sciences (iCeMS), Kyoto University

2P-110Effective Nose-to-Brain Co-delivery of Antisense Oligonucleotide and RNase H via
Polyion Complex Vesicle for Improving Treatment of Neurodevelopmental
Disorders
Beob Soo Kim,1,* Kanjiro Miyata1,*
1

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo







2P-111

Characterization of a bifunctional aptamers and improvement of drug effects
Hiroto Fujita,1 Yuka Kataoka,2 Masayasu Kuwahara1,*
1

Graduate School of Integrated Basic Sciences, Nihon University

2P-112

Non Invasive Regulation of Cellular Morphology Using a Photoswitchable
Mechanical DNA Polymer
Soumya Sethi,1 Kumi Hidaka,1 Ganesh N. Pandian,2 Hiroshi Sugiyama,1, 2,* Masayuki Endo2, 3,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material
Sciences (WPI-iCeMS), Kyoto University, 3Organization for Research and Development for Innovative Science andTechnology, Kansai University

2P-113

Preparation and structure analysis of oligonucleotide-metal ion complexes
Takahiro Atsugi,1 Ryo Yoshikawa,1 Jiro Kondo2, Akira Ono1*
1

Department of Materials & Life Chemistry, Faculty of Engineering, Kanagawa University, 2Department of Materials
and Life Sciences, Faculty of Science and Technology, Sophia University

2P-114

Synthesis and metal ion bindings of oligonucleotides having functional groups
on pyrimidine bases
Daiki Miyano,1 Atsuya Murata,1 Rika Nishihara,1 Akira Ono1*
1

Department of Materials & Life Chemistry, Faculty of Engineering, Kanagawa University

2P-115

Regulation of thrombin activity by a linear hexaoxazole G-quadruplex ligand
controlling thrombin-binding aptamer topologies
Shogo Sasaki,1 Yue Ma,1 Kazunori Ikebukuro,1 Masayuki Tera,1 Kazuo Nagasawa1,*
1

Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture andTechnology

2P-116Development of a Cyclic Pyrrole–Imidazole Polyamide that Strongly andSpecifically Binds to CAG/CTG Repeats
Yuki Hirose,1 Tomo Ohno,1 Kaori Hashiya,1 Toshikazu Bando,1,* Hiroshi Sugiyama1,2,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material
Science (WPI-iCeMS), Kyoto University

2P-117

Evaluation of Linear Pyrrole–Imidazole Polyamides with Various N-Terminal
Modifications
Hatanaka Junnosuke,1 Yuki Hirose,1 Kaori Hashiya,1 Toshikazu Bando,1,* Hiroshi Sugiyama1,2,*
1

Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-Material
Science (WPI-iCeMS), Kyoto University