Cancer &Tumor Markers
Reagents for Assay Development
ISO Certified 13485:2016

www.MeridianLifeScience.com

Company Overview

Extensive Capabilities & Services
Molecular Reagents
qPCR | RT-qPCR | LAMPENZYMES

Immuno Reagents
Antigens | Antibodies | Blockers•	Hot-Start Taq technologies - chemical,
antibody, aptamer

VIRUS MANUFACTURING•	Lyo & Air-Dryable enzymes (glycerol free) Taq,
Bst, RTase•	Proprietary Ag purification•	Live or inactivated•	Thermostable MMLV RT

RECOMBINANT PROTEINSMASTER MIXES•	Lyo & Air-Dryable formats•	Inhibitor-tolerant mixes for stool, sputum, saliva,
blood, plant, water.
•	For multiplexing, GC-rich templates•	
E. coli, P. pastoris, S. cerevisiae, Sf9,
Mammalian (CHO, HEK293)•	10L- 130L fermentation

ANTIBODIES – MAbs/PAbs•	500+ MAbs produced in grams

II

NUCLEOTIDES•	Multi-Kilograms of MIgG / year•	dNTPs, Na or Li salts•	Hundreds of liters of GxhIgG•	Ultra high purity, >99%•	Ascites production (55,000 Mice)

Cancer & Tumor Markers - Reagents for Assay Development

Commercial scale manufacturingof antigens and antibodies withprotein purification expertise.
Meridian has been providing innovative life science solutions and building
trusted partnerships for over 43 years. Meridian’s focus is to offer complete
solutions for the development of molecular and immunological assays.
• Full line of immunoassay reagents, including antigens, antibodies and blockers• Large scale production of reagents for molecular assays• Technical support with assay development experience• Dedicated R&D and manufacturing teams•R obust and mature Quality System

ISO Certified 13485:2016

Global presence
WATERLOO, Belgium
QUEBEC, Canada

LONDON, United Kingdom
LUCKENWALDE, Germany

BILLERICA, MA
MANASQUAN, NJ
CINCINNATI, OH (Headquarters)

BEIJING, China

PARIS, France

CHANGZHOU, China

MILAN, Italy
MEMPHIS, TN
BOCA RATON, FL

MODIIN, Israel

SYDNEY, Australia

Diagnostic Manufacturing |Life Science Manufacturing |Sales & Warehouse

MERIDIAN BIOSCIENCE, INC.
Parent Company | Founded in 1977 | Nasdaq: VIVO | 750+ Employees
Headquartered in Cincinnati, OH | Presence in 70+ Countries.

www.MeridianLifeScience.com

IIICompany Overview
Antigens & Antibodies
INFECTIOUS DISEASE EXPERTISE

IV

Tropical

ToRCH & Childhood

Viral Hepatitis•	Zika•	Dengue 1, 2, 3, 4
•	Chikungunya•	Malaria•	Chagas•	Leishmaniasis•	Leptospirosis•	Newcastle Disease•	Yellow Fever•	Nipah Virus•	JEV•	Toxo•	Rubella•	CMV•	HSV-1,2•	Rubeola•	EBV•	Mumps•	Coxsackie•	Rotavirus•	RSV•	Parvo B19•	VZV•	HAV•	HBV•	HCV•	HDV•	HEV

Cancer & Tumor Markers - Reagents for Assay Development

STD•	HSV-1, 2•	HIV-1, 2•	HPV•	Syphilis•	Chlamydia•	Neisseria

Gastro•	
H. Pylori•	C. Difficile•	Norovirus•	Adenovirus•	Rotavirus•	Cryptosporidium•	Campylobacter•	
E. Coli•	Salmonella•	
G. Lambia•	Astrovirus

Respiratory•	SARS-CoV-2•	
M. Pneumoniae•	
C. Pneumoniae•	Influenza A, B
•	Parainfluenza•	
L. Pneumophilia•	RSV•	
M. Tuberculosis•	Streptococcus•	Staphylococcus•	Adenovirus

Cardiac

Cancer

Veterinary

Drug of Abuse•	Troponin I, T•	Myoglobin•	BNP•	NT-proBNP•	CRP•	PCT•	CK-MB•	D-Dimer•	Cystatin-C•	Galectin-3•	Vitamin D•	Apo A, B, E
•	NSE•	FABP•	SAH•	MPO•	Fibrinogen•	EGF•	Lp-PLA2•	PAPP-A•	CA125•	CA15-3•	CA19-9•	CA72-4•	CA50•	CA242•	Cyfra 21-1
•	CEA•	Thyroglobulin•	erbB-2/HER2•	AFP•	EGFR•	HE4•	NSE•	PMA•	PAP•	PSA•	PSMA•	S-100•	PIVKA II•	B2M•	ASFV•	Avian Influenza•	Borrelia•	
Brucella abortus•	Canine Distemper•	Feline
Immunodeficiency•	Feline Leukemia•	Foot-and-Mouth•	Canine Heartworm•	Infectious Bursal
Disease•	Marek Disease•	Newcastle Disease•	Canine Parvovirus•	Rabies Virus•	Serum Amyloid A (SAA)• Trichomonas foetus•	Nipah•	Transmissible
Gastroenteritis•	Amphetamine•	Barbital•	Benzodiazepine•	Buprenorphine•	Cocaine•	Cotinine•	EDDP•	Fentanyl•	Ketamine•	K2•	MDMA (Ecstasy)•	Methadone•	Methamphetamine•	Morphine•	Norketamine•	Opium•	Oxycodone•	PCP•	Phenobarbital•	Propoxyphene•	THC

Autoimmune

Microbial Detection•	Jo-1•	PCNA•	pANCA•	cANCA•	Sm Ag•	dsDNA•	La(SSA)•	Ro(SSA)•	Histone•	GMB•	C1q•	Scl-70•	SS-A•	BS-Gly-1•	Cathepsin G•	Calprotectin•	Legionella•	Salmonella•	Cryptosporidium•	
G. Lambia•	
C. Jejuni•	
E. Coli•	
B. Anthracis•	Clostridium•	Listeria•	Streptococcus•	Staphylococcus

Immunoglobulins/
Blockers

Hormones•	LH, FSH, hCG,
•	hGH, AMH•	Cortisol•	Estradiol•	Insulin, C-peptide•	Prolactin•	Progesterone•	PTH•	PAPP-A•	TSH, T3, T4, ACTH
•	Thyroglobulin

Allergens•	Cat & Dog Allergen•	Horse Allergen•	Dust Mite
• Alternaria alternate•	Timothy Grass•	
Platanus acerifolia•	Mugwort•	TRU Block™ &IgM Diluent•	Animal IgGs – Bovine,
Chicken, Goat, Mouse,
Rabbit, Sheep•	Human IgA, IgG,
IgM, IgE• Kappa Light chain• Lambda Light chain•	Goat Anti-Human
IgG, IgM, IgA•	Goat Anti-Mouse IgG

www.MeridianLifeScience.com

VRespiratory Infections & Diagnosis
Cancer is a leading cause of death worldwide. More than half of allcancer deaths each year are due to lung, stomach, liver, colorectal andfemale breast cancers. If recent trends in major cancers continue globallyin the future, the burden of cancer will increase by 68% over the next 15
years. The high cancer mortality rates are primarily due to a delayed
detection of the disease and differences in the policies on cancer
screening between countries.
Early detection is the key focus of cancer
diagnostics and an early diagnosis makes it
possible to cure the disease completely and/or
increase survival rates. However, the financial
burden associated with the cost of managing andtreating cancer is a growing concern. Non-invasive
techniques such as serum immunoassays
detecting specific tumor markers are highly sought
after in order to minimize the costs associatedwith screening and monitoring the disease. They
provide fast, cost-effective, and accurate cancer
detection while providing a valuable aid to theclinician and increased comfort to the patient.
Cancer biomarkers (also called tumor markers) areproteins produced either by the tumor itself or by
the body in response to the presence of cancer.
They can be broadly classified into four groups:(1) screening and early detection, (2) diagnostic
confirmation, (3) prognosis and prediction oftherapeutic response, and (4) monitoring disease
and recurrence.
Over the past decade, an improved understandingof carcinogenesis and tumor progression has
revealed a large number of potential tumor markers.
Some markers are associated with only one typeof cancer, whereas others are associated with
two or more cancer types. No “universal” tumor
marker that can detect any type of cancer has
been discovered.

VI | Cancer & Tumor Markers for Assay Development

FDA Approved Biomarkers for Cancer

Thyroid Cancer (Tg)

Breast Cancer (CA15-3/MUC-1,
CA27-29, CEA, erb.2/HER2/new)
Pancreatic Cancer (CA19-9, CEA)
Liver Cancer (AFP)
Colon Cancer (CEA)
Ovarian Cancer (CA125, HE4)
Prostate Cancer (PSA)

Product Quickfind List
A

D

N

Alpha 1 Antitrypsin (A1AT)...................... 4
Alpha 2 Macroglobulin (A2M)................. 4
Alpha Fetoprotein (AFP)......................... 4
Amylase.................................................. 5
Apolipoprotein CI (Apo CI)...................... 5
Apolipoprotein E (Apo E)........................ 5

Defensin-beta....................................... 13
Desmin.................................................. 14
Disialoganglioside GD2......................... 14

NGAL/Lipocalin-2.................................. 19
NSE....................................................... 19

E

Osteopontin (OPN)............................... 19P

Beta 2 Microglobulin (B2M)................... 6

Elastase................................................. 14
EGFR..................................................... 14
erbB-2, HER2/neu................................. 15
EpCAM ................................................. 15CF

Cadherin-E............................................... 6
Calcitonin................................................ 6
Calprotectin L1........................................ 6
CA125..................................................... 7
CA15-3/MUC1)....................................... 7
CA19-9.................................................... 8
CA50....................................................... 8
CA72-4 (TAG-72)..................................... 8
CA242..................................................... 8
CEA......................................................... 9
Catalase.................................................. 9
CD1d....................................................... 9
CD3......................................................... 9
CD8....................................................... 10
CD13 (Aminopeptidase N)................... 10
CD15..................................................... 10
CD24..................................................... 10
CD28..................................................... 10CD30..................................................... 10
CD37..................................................... 11
CD42 .................................................... 11
CD49d................................................... 11
CD57 .................................................... 11
CD59..................................................... 11
CD66b................................................... 11
CD90..................................................... 12
CD105 (Endoglin).................................. 12
CD147................................................... 12
CD177................................................... 12
CD195 (CCR5)...................................... 12
Centromere Protein B (CENPB)........... 13
c-Myc.................................................... 13
Collagen Type VI................................... 13
Cyfra 21-1.............................................. 13

Factor H (Beta 1H)................................ 15
Factor VIII (FVIII).................................... 15

BO

Pepsinogen I and Pepsinogen II .......... 20
PIVKA-II................................................. 20
Prolactin (PRL)...................................... 20
Prostate Secretory Protein (PSP)......... 20
PSA....................................................... 20RGRetinol Binding Protein 4 (RBP4)......... 21

GAPDH ................................................. 15S

HHeat Shock Proteins............................. 16
Hemoglobin.......................................... 16
HE4....................................................... 16

S-100..................................................... 22
Serum Amyloid A (SAA)....................... 22
Sialyl Lewis A and Sialyl Lewis X......... 22
Superoxide Dismutase (SOD).............. 23

I

T

IGF-I ...................................................... 16
IGFBP-3................................................. 17
Integrin alpha M (CD11b/MAC-1)......... 17
Interferon gamma (IFN-gamma).......... 17
IL-1a and IL-1R ..................................... 17

Thymus and Activation Regulated
Chemokine (TARC)............................... 23
Thyroid Peroxidase (TPO)..................... 23
Thyroglobulin (Tg)................................. 23
Tissue Transglutaminase (tTG)............. 23
Trypsin................................................... 24
TNF-alpha ............................................. 24

L

Lactate Dehydrogenase (LDH)............. 17
Lamin.................................................... 18
Leptin.................................................... 18
Lysozyme.............................................. 18
M

U

Urokinase (uPA).................................... 24
V

Vitronectin............................................. 24

Microtubule Associated Protein 2(MAP-2)................................................. 18
Mast Cell Tryptase (MCT)..................... 18
Monocyte Chemotactic
Protein 1 (MCP-1)................................. 19

www.MeridianLifeScience.com

1

Leading Products
Antibodies & Matched Pairs
Alpha Fetoprotein (AFP)
M86304M
M86641M

MAb (Capture), ELISA
MAb (Detection), ELISA

Epidermal Growth Factor Receptor 2(ERB2, HER2/NEU)* Reacts with soluble B2M and B2M associated with cell-surface MHC ClassI molecules and other membrane antigens.

M01296M	MAb, ELISA, reacts with peptide ILDV4(dephosphorylated)
M01297M	MAb, ELISA, reacts with peptide ILDV4(phosphorylated)
M01298M	MAb, ELISA, reacts with peptide ILDV2(dephosphorylated)
M01299M	MAb, ELISA, reacts with peptide ILDV2(phosphorylated)

CA125

HE4

* Not cross reactive with human albumin.

MAM01-210 MAb (Capture), ELISA
MAM01-301 MAb (Detection), ELISA

Beta 2 Microglobulin (B2M)
MCP17-301 MAb, ELISA & RIA

M86306M
M86924M

MAb Group A (Capture), ELISA & WB
MAb Group B (Detection), ELISA & WB

M01323M
M01320M

MAb (Capture), ELISA
MAb (Detection), ELISA

M86306M
M86429M

MAb Group A (Capture), ELISA & WB
MAb Group B (Detection), ELISA & WB

M01323M
M01321M

MAb (Capture), ELISA
MAb (Detection), ELISA* Both pairs detect OC125 (Group A) and M11 (Group B).

Human Hemoglobin (Fecal Occult Blood)

CA19-9H01348M
H01349M

MAb (Capture), ELISA
MAb (Detection), ELISA

H01416M
H01369M

MAb (Capture), ELISA
MAb (Detection), ELISA

H01409M
H01410M

MAb (Capture), LF & Turbidimetry
MAb (Detection), LF & Turbidimetry

M66107M
M66106M
M66108M

MAb (Capture), ELISA
MAb (Detection), ELISA
MAb (Alternate Detection), ELISA

M66106M
M66108M

MAb (Capture/Detection), ELISA
MAb (Capture/Detection), ELISA* Abs can be used as capture or detection in a sandwich assay.

CA72-4
M01341M
M01342M
M01340M

MAb (Capture), ELISA
MAb (Alternate Capture), ELISA
MAb (Detection), ELISA

CEA
MAM02-008 MAb (Capture/Detection), ELISA
MAM02-009 MAb (Capture/Detection), ELISA* Abs can be used as capture or detection in a sandwich assay.

MAM02-009 MAb (Capture), ELISA
MAM02-881 MAb (Detection), ELISA
M01250M
M01246M

MAb (Capture), ELISA & IHC
MAb (Detection), ELISA & IHC

Neuron Specific Enolase (NSE)
M86101M
M86520M* Abs can be used as capture or detection in a sandwich assay.

Pepsinogen I
K01402M
K01403M

MAb (Capture), ELISA & LF
MAb (Detection), ELISA & LF

K01406M
K01407M

MAb (Capture), ELISA & LF
MAb (Detection), ELISA & LF

Pepsinogen II
K01404M
K01405M* Specific for CEA epitope specificity group I.

PIVKA-II

Cyfra 21-1 (Cytokeratin 19)

M01344M
M01343M

M01300M
M01326M

MAb, ELISA & WB
MAb, ELISA

MAb (Capture/Detection), ELISA
MAb (Capture/Detection), ELISA

MAb (Capture), ELISA & LF
MAb (Detection), ELISA & LF
MAb (Capture), ELISA
MAb (Detection), ELISA

Prostate Specific Antigen (PSA) Free
M92986M
M92396M

MAb (Capture), ELISA
MAb (Detection), ELISA

M86506M
M86806M

MAb (Capture/Detection), ELISA & LF
MAb (Capture/Detection), ELISA & LF

* Not cross reactive to Albumin, AFP, CEA, PAP, CA125, CA19-9 or CA15-3.

2 2| Cancer
Cancer& &Tumor
TumorMarkers
Markersfor- Reagents
Assay Development
for Assay Development

Prostate Specific Antigen (PSA) Total
M66276M
M86506M

MAb (Capture), ELISA & LF
MAb (Detection), ELISA & LF

M01236M
M86506M

MAb (Capture), ELISA & LF
MAb (Detection), ELISA & LF

* Specific for epitope 5 and not cross reactive with human kallikrein 2.

S-100 Beta
Q86006M
Q86610M

Q86003M
Q86610M

MAb (Capture), ELISA
MAb (Detection), ELISA* Each capture is specific for alpha-beta and each detection for alpha-beta
and beta-beta.

Thyroglobulin
E01326M
E01325M

MAb (Capture), ELISA
MAb (Detection), ELISA* Does not interfere with anti-thyroglobulin auto-antibodies.

MAb (Capture), ELISA
MAb (Detection), ELISA

Human Antigens (for use as standards, controls & calibrators)
Alpha Fetoprotein (AFP)

Neuron Specific Enolase (NSE)

A32260H 	Produced in cell culture, derived from a liver
tumor cell and contains approximately 70% of
the AFP-L3 isoform, ≥ 95% pure (SDS-PAGE& WB)

A86803H

Beta 2 Microglobulin (B2M)
A01412H

From human urine, ≥ 98% pure (SDS-PAGE)

CA15-3
A32231H

From native human metastatic liver carcinoma

Produced in cell culture, low cross reactivity

CA50
A01264H	Produced in cell culture, provided as cell
culture concentrate

CEA
Produced in cell culture, > 50% pure (SDS-PAGE)

A38151H	From native human liver metastases,> 95% pure (SDS-PAGE)

Cyfra 21-1
A32340H

A01420H	From human gastric mucosa, > 90% pure
(SDS-PAGE)

Prostate Specific Antigen (PSA)

CA72-4

A32030H

Pepsinogen II

Produced in cell culture, low cross reactivity

A01458H	Produced in cell culture, provided as cell
culture concentrate
A01723H

A01691H	Purified from human stomach, lyophilized,≥ 90% pure (SDS-PAGE)

A01692H	Purified from human stomach, lyophilized,≥ 90% pure (SDS-PAGE)

CA19-9A86199H

Pepsinogen II

Produced in cell culture, low cross reactivity

CA125
A32180H

From human brain, > 95% pure (SDS-PAGE)

A01368H	PSA, from human seminal fluid, lyophilized,> 95% pure (SDS-PAGE)
A31029H	PSA/ACT Complex, from human seminal fluid
and plasma, > 95% pure (SDS-PAGE)
A86878H	PSA, From human seminal fluid, lyophilized,> 98% pure (SDS-PAGE)

S-100 Beta
A86809H	From human brain tissue, contains bothbeta-beta and alpha-beta isoforms, > 95% pureA86289H	From human brain tissue, contains only
beta-beta homodimer, > 95% pure (SDS-PAGE)

Thyroglobulin
H6T08-747

From human thyroid tissue, > 98% pure (SDS-PSGE)

A86852H

From human thyroid tissue, > 90% pure (SDS-PAGE)

Produced in cell culture, low cross reactivity

Human Hemoglobin (Fecal Occult Blood)
A38192H	From human erythrocytes, > 96% pure
(SDS-PAGE)

www.MeridianLifeScience.com
www.MeridianLifeScience.com |3 3

Product list
Abbreviations

Alpha 1 Antitrypsin (A1AT)

Ag – Antigen

A1AT is a secretory glycoprotein mainly produced in the liver
and monocytes. It is the most abundant serine proteaseinhibitor in human plasma. Several cancers are associated with
A1AT deficiency including primary liver carcinoma, lung cancer,
bladder cancer and malignant hepatoma.

Alk.Phos. – Alkaline Phosphatase conjugated product

Monoclonals

CLIA – Chemiluminescence Immunoassay• Does not cross-react with alpha 1 antichymotrypsin
H45200M

6-His – Polyhistidine-tag
Aff.Pur. – Affinity Purified, analyte-specific column

CVD – Cardiovascular Disease
DB – Dot Blot
DFA – Direct Immunofluorescence Assay
FC – Flow Cytometry
FITC – Fluorescein conjugated product
GST – Glutathione S-transferase
HRP – Horseradish peroxidase conjugated product
IB – Immunoblot
ICC – Immunocytochemistry
IEP – Immunoelectrophoresis
IFA – Immunofluorescence Assay
IgG – Immunoglobin G
IgM – Immunoglobin M

Alpha 2 Macroglobulin (A2M)
A2M functions as a universal protease inhibitor in serum andis capable of binding various cytokines and growth factors.
Malignant tumors are able to synthesize and release proteins
into the circulation, including A2M that protects the tumor
against immune system attacks. A common variant of A2M
has also been suggested to lead to an increased risk of
Alzheimer’s disease.

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

L04330G

Goat

Monospecific

IEP

IHC – Immunohistochemistry

Antigens

IP – Immunoprecipitation

A50114H
		

LF – Lateral Flow

• Native antigen from human plasma• > 95% pure (SDS-PAGE), lyophilized

Lysate – Cells which have been lysed
MAb – Monoclonal antibody
Monospecific – Single band when tested byimmunoelectrophoresis
Neat – Whole, unpurified, undiluted antisera
Neph – Product has been quality controlled byNephelometry
PAb – Polyclonal antibody
Purified/IgG – Refer to the Certificate of Analysis
regarding the extent of purification and the purification
process used.
RIA – Radioimmunoassay
RID – Radial Immunodiffusion
SDS-PAGE – Sodium Dodecyl Sulfate Polyacrylamide
Gel Electrophoresis
TIA – Product has been quality controlled by
Turbidimetry
WB – Western blot

Alpha Fetoprotein (AFP)
AFP is a tumor marker used to help detect and diagnose cancersof the liver, testicles, and ovaries. AFP can be fractionated byaffinity electrophoresis into 3 glycoforms: L1, L2, and L3.
AFP-L3 is specific to malignant tumors. An AFP-L3 test is used
to help evaluate the risk of developing hepatocellular carcinoma,
especially in those with chronic liver disease, and also to evaluate
response of hepatocellular carcinoma to treatment.

Monoclonals• Does not cross-react with human serum albumin• Suitable for ELISA• MAbs produced in vivo (unless otherwise noted)
M01254M
M01255M* Also works in LF assays
M86304B* Biotin conjugatedM86641M
M86501M* Reacts with AFP Receptor, suited to blocking AFP/
AFP-binding

4 4| Cancer
Cancer& &Tumor
TumorMarkers
Markersfor- Reagents
Assay Development
for Assay Development

Alpha Fetoprotein (AFP) continued

Apolipoprotein CI (Apo CI)

Antibody Pairs

Apo CI is the smallest member of the apolipoprotein family
and is mainly distributed on the surface of very low density
lipoprotein (VLDL) chylomicrons and high density lipoprotein.
Apo CI is a potential serum marker for colorectal cancer,
prostate cancer, breast cancer, lung cancer, thyroid carcinoma,
malignant pleural mesothelioma, gastric cancer, pancreaticcancer and Wilms’ tumor.

• Suitable for ELISA• MAbs produced in vivo (unless otherwise noted)
CAPTURE
DETECTION
H45610M

H45301M

MAM01-210
M86304M

MAM01-301
M86641M* Does not react with human albumin,
ferritin, hCG or PSA* Does not react with human albumin

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K92204R

RabbitPurified

ELISA

Antigens
A01406H
				• Native antigen from human cord serum• Suitable for use in ELISA and WB• > 99% pure (SDS-PAGE)

A01407H
				• Native antigen from human cord serum• Suitable for use in ELISA and WB• > 99% pure (SDS-PAGE), lyophilized

A32260H• Native antigen from human hepatocellular
carcinoma cell line
• Contains approximately 70% of the
AFP-L3 isoform• 95% pure (SDS-PAGE)• Suitable for use in ELISA and WB

		
		
		

Amylase
Amylase is produced by the exocrine pancreas and the salivary
glands to aid in the digestion of starch. Amylase enzyme levels
may be increased in some pancreas, salivary, prostate, lungand ovarian tumors. In general, the blood amylase test is used
to help diagnose and monitor acute pancreatitis.

Antigens
A38120H
				
A38211H
				
A01389P
				• Native alpha amylase from human pancreas• Specific activity of 450 Units/mg protein (lotdependent)• Purified and lyophilized

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K74110R

Rabbit

Aff.Pur.

ELISA,IB

Apolipoprotein E (Apo E)
Apo E is a class of apolipoproteins found in the chylomicronand intermediate-density lipoprotein. It has been linked to
cardiovascular disease, Alzheimer’s disease, dementia,
atherosclerosis, multiple sclerosis, peripheral artery disease,diabetes, stroke, and most recently, cancer, including breastand ovarian cancer.

Monoclonals•	Reacts to the E2, E3 and E4 isoforms of apolipoprotein E• Produced in vivo
• Suitable for ELISA, IHC, IP and WB
H06579M•	Reacts with VLDL of human plasma• Suitable for use in ELISA and IHC• Produced in vivo, lyophilized
H61529M

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

G5C27-766
K34002G
K74190G
K74180B

Goat
Goat
Goat
Goat

Aff.Pur.
HRP
Aff.Pur.
BiotinN/AELISA,WB
ELISA,WB
ELISA,WB

Antigens
A50120H		• Native antigen from human plasma (VLDL)• > 95% pure (SDS-PAGE)• Native alpha amylase from human saliva• Specific activity of 620 Units/mg protein (lotdependent)• > 90% pure (SDS-PAGE), lyophilized• Native alpha amylase from pig pancreas• Specific activity of 640 Units/mg protein (lotdependent)• Purified and lyophilized

www.MeridianLifeScience.com
www.MeridianLifeScience.com |5 5

Product list | Continued
Monoclonals

Beta 2 Microglobulin (B2M)
B2M is a protein involved with MHC class I molecules which
is found on the surface of almost all nucleated cells. Elevatedlevels of B2M are noted in lymphoproliferative disorders,neoplasms (malignant and benign), inflammatory disease, andautoimmune diseases such as systemic lupus erythematosus
and Sjögren’s disease. For cancer, it is not diagnostic for a
specific type, but it has been associated with the amountof cancer present (tumor burden) and can be used as aprognostic tumor marker for some blood cell cancers.

Monoclonals•	Recognizes the HLA-B2M complex, free or associated withthe membrane• Suitable for use in FC, IHC and IFA• Lyophilized
H42114M•	Reacts with soluble forms of B2M and B2M associatedwith cell-surface MHC Class I molecules and othermembrane antigens• Suitable for use in ELISA, WB, FC, IP, and RIA
MCP17-301

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K01372G

Goat

Aff.Pur.

N/A

Antigens
A01447H
				• Native antigen from human urine• Suitable for use in ELISA• 98% Purity (SDS-PAGE)

A01410H		• Native antigen from human urine• > 98% Purity (SDS-PAGE), lyophilized

A01412H		• Native antigen from human urine• 98% Purity (SDS-PAGE)

A01468H
		• Recombinant (E.coli)• 95% Pure (HPLC), lyophilized

Cadherin-E
Cadherin-E is a calcium dependent cell adhesion molecule
expressed predominately in epithelial tissues. It plays animportant role in the growth and development of cells via themechanisms of tissue architecture and the maintenance oftissue integrity. It is an important determinant of tumor
progression, serving as a suppressor of invasion and metastasis(loss of Cadherin-E function promotes tumor progression).

6 6| Cancer
Cancer& &Tumor
TumorMarkers
Markersfor- Reagents
Assay Development
for Assay Development•	Recognizes Cadherin-E expressed on non-neuronal
epithelial cells• Suitable for use in IHC and IP• Produced in vivo, lyophilized
P91176M

Calcitonin
Calcitonin is polypeptide hormone that is produced by the
C-cells of the thyroid gland and it acts to reduce blood calcium(Ca2+), opposing the effects of parathyroid hormone (PTH).
Calcitonin assay is used to identify patients with nodular
thyroid diseases and to diagnose medullary thyroid cancer.

Antibody Pairs•	Suitable for use in CLIA, ELISA and RIA•	Recognizes Native Human Calcitonin
CAPTURE
DETECTION
E01357M

E01356M

Calprotectin L1
Calprotectin L1 is a neutrophil-derived protein that can bequantified in the feces and has become an established marker
of whole gut inflammation. Fecal calprotectin levels areassociated with lifestyle risk factors for colorectal cancer.

Antibody Pairs•	Suitable for use in ELISA with stool samples• MAbs produced in cell culture, lyophilized
CAPTURE
DETECTION
K01373M

K01376M•	MAb to Calprotectin• Produced in cell culture• Suitable for ELISA and lateral flow
CAPTURE
DETECTION
9591

9591

Monoclonals• Suitable for use in ELISA• Produced in cell culture, lyophilized
K01374M
K01375M

Cancer Antigen 125 (CA125)

Cancer Antigen 15-3 (CA15-3 or MUC1)

A protein in humans that is encoded by the MUC16 gene andfound on the surface of many ovarian cancer cells. Monitoring
CA125 blood serum levels is also useful for determining how
ovarian cancer is responding to treatment and for predicting apatient’s prognosis after treatment. CA125 can also be found inother cancers and in small amounts in normal tissue.

CA15-3 is a tumor marker which corresponds to an immunodominant epitope in the extracellular portion of the membranebound mucin MUC1. It is used to monitor a patient’s response
to breast cancer treatment and disease recurrence. CA15-3
and the associated CA27.29 are different epitopes on the samegene product.

Antibody Pairs

Antibody Pairs• Detects both Group A and Group B• Suitable for use in ELISA and WB• MAbs produced in in vivo
CAPTURE
DETECTION•	Binds to an epitope within the VNTR tandem repeat peptide
region of MUC1
• Suitable for use in ELISA and IHC• MAbs produced in in vivo
CAPTURE
DETECTION SPECIFIC FOR CA15-3

M86306M
M86306M

M86924M
M86429M

Monoclonals• Suitable for use in ELISA and WB• MAbs produced in vivo
M86306B* Specific to Group A, biotin conjugatedM86429B* Specific to Group B, biotin conjugated

Antigens
A01693H		• Ovarian Cancer, Calibrator Grade• Low cross-reactivity

A32180H• Suitable for use as a calibrator for single ormultiple analyte controls• Low cross-reactivity ideal for multi-analyte panels• Cell culture derived protein

				
A97180H
		
A86125H
		
A86928H
				
A01690H				• Cell culture derived protein from ovariancarcinoma cell line
• Suitable for use in WB and RIA• Cell culture derived protein from humanadenocarcinoma cell line
• Suitable for use as a calibrator

M86240M
M86240M

M01289M
M86240M* Underglycosylated* Unglycosylated

Antigens
A32231H
						• Low cross-reactivity ideal for multi-analyte panels• Suitable for use as a calibrator or control• Suitable for use in CLIA
• Cell culture derived protein from human BTA
cell line

A86153H
		• Native antigen from human milk
• Suitable for use as a calibrator or as an
immunogen for antibody development

A32000H		• Suitable for use in CLIA and WB• Cell culture derived protein from human BTA
cell line

A01436H
		• Native antigen from human fluids• High purity (relative Purity Ratio: > 20,000
Units/mL/OD280nm)• Suitable for use in ELISA and WB		Please note that cell culture derived antigens offer several advantages
over the native fluid versions, including greater availability of the product.

• Cell culture derived protein from humanadenocarcinoma cell line
• Suitable for use as a calibrator• > 50% pure (SDS-PAGE)• Partially pure antigen from human fluids• Low cross-reactivity• Suitable for use in ELISA andElectrochemiluminescence assay as acalibrator or control

Please note that cell culture derived antigens offer several advantages
over the native fluid versions, including greater availability of the product.

www.MeridianLifeScience.com
www.MeridianLifeScience.com |7 7

Product list | Continued
Cancer Antigen 19-9 (CA19-9)

Cancer Antigen CA72-4 (TAG-72)

Also called sialylated Lewis (a) antigen, CA19-9 is a tumor
marker used primarily in the management of pancreatic cancer.
CA19-9 is also elevated in many types of gastrointestinal cancer,
such as colorectal cancer, esophageal cancer and hepatocellular
carcinoma. Apart from cancer, elevated levels may also occur inpancreatitis, cirrhosis, and diseases of the bile ducts.

CA72-4 is a mucinous glycoprotein used as a tumor marker
for gastric carcinoma and ovarian cancer (clinical studies
demonstrated diagnostic specificity of more than 95%).
Elevated CA72-4 levels in serum and plasma have also beenreported in other cancers including carcinomas of the pancreas,
stomach, gallbladder, colon, cervix and endometrium. There isa good correlation between serologic CA72-4 levels and tumor
stage and size. It has been used as an independent marker forthe therapeutic monitoring and follow-up care of ovarian cancer
patients, in particular in CA125 negative patients.

Monoclonals• Suitable for IHC• Produced in in vivo
M01237M

Antibody Pairs

Antibody Pairs• Suitable for use in ELISA• MAbs produced in vivo (unless otherwise noted)
CAPTURE
DETECTION
M66106M
M66107M

M66108M
M66106M

M66107M
M66108M

M66108M
M66106M* Pair does not cross-react CA72-4,
PSA, CA125, CA242, and CEA

Antigens
A32502H
		• Cell culture derived protein from humanadenocarcinoma cell line
• Suitable for use in CLIA

A86199H
		• Native antigen from metastatic liver carcinoma• Suitable for use as a calibrator and an
immunogen for antibody development

A01458H		• Cell culture derived protein• Concentrated (~76,000 U/mL), lot dependent

Please note that cell culture derived antigens offer several advantages
over the native fluid versions, including greater availability of the product.

Cancer Antigen 50 (CA50)
CA50 cancer antigen is a glycolipid and elevated levels of CA50
are found in liver cirrhosis and diseases of the pancreas. CA50
is most prevalent in gastrointestinal cancers, but can also be
associated with cancer outside the digestive tract.

Antigens
A01264H• Cell culture derived protein

Please note that cell culture derived antigens offer several advantages
over the native fluid versions, including greater availability of the product.

8 8| Cancer
Cancer& &Tumor
TumorMarkers
Markersfor- Reagents
Assay Development
for Assay Development• Suitable for use in ELISA• MAbs produced in vivo
CAPTURE
DETECTION
M01341M
M01342M

M01340M
M01340M

Cancer Antigen 242 (CA242)
CA242 is related to the sialylated Lewis (a) blood group antigen(Ag-CA19-9) but it is chemically and immunologically distinct. It
is used as a tumor marker for the early diagnosis of pancreaticcancer. It has been demonstrated that the CA242 and CA19-9
epitopes are co-expressed on the same mucins, however
the detailed structure of the CA242 epitope has not been
established. CA242 is suggested to be more specific thanCA19-9 in the diagnosis of pancreatic cancer and overall there
are differences in the relative expression of CA19-9 and CA242
between benign and malignant diseases and between
carcinomas of various organs.

Antigens
A01267H		• Cell culture derived protein• Suitable for use as a calibrator

Please note that cell culture derived antigens offer several advantages
over the native fluid versions, including greater availability of the product.

Carcinoembryonic Antigen (CEA)

Catalase

CEA is a type of glycoprotein molecule that is produced by cellsof the gastrointestinal tract during embryonic development andCEA is generally present in low levels in the blood. Elevatedlevels of CEA are detectable in certain types of cancer andto-date CEA is the most widely used tumor marker for assessing
prognosis, detecting recurrence and monitoring treatment inpeople with colorectal cancer. High levels of CEA are also
detectable in cancers of the pancreas, stomach, breast, lung,medullary carcinoma of the thyroid, and ovarian cancer.

Catalase is an important enzyme that protects cells fromoxidative damage by reactive oxygen species. Catalase isfrequently down-regulated in tumors although the underlying
mechanism remains unclear. It has been recommended foruse as a biomarker for the diagnosis, prognosis, andtreatment of breast cancer.

Monoclonals•	Suitable for use in enzyme conjugation, radio-labeling or
solid phase immobilization• Produced in vivo
H45655M• Suitable for use in FC• Specific for epitope group V
M01329M

Antibody Pairs• Suitable for use in ELISA• MAbs produced in vivo
CAPTURE
DETECTION
MAM02-008
MAM02-009
MAM02-009
MAM02-009
M01250M

MAM02-009
MAM02-007
MAM02-008
MAM02-881
M01246M

A50136H
				• Native antigen from human erythrocyte• 95% pure (SDS-PAGE)• > 50,000 units/mg protein (lot dependent)

CD1d
CD1d encodes a divergent member of the CD1 family oftransmembrane glycoproteins, which are structurally related tothe major histocompatibility complex (MHC) proteins and form
heterodimers with beta-2-microglobulin. Studies have shownthat breast cancer cells, through downregulation of CD1d andsubsequent evasion of NKT-mediated antitumor immunity, gainincreased potential for metastatic tumor progression.

Monoclonals• Suitable for use in IHC and IP• Produced in cell culture
P01242M* Also works in IHC

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K10290G

Goat

Neat

ELISA

Antigens
A01442H				• Native antigen from human fluids• Suitable for use in ELISA• 98% (SDS PAGE)

A86808H
		• Native antigen from human fluids• Suitable for use in ELISA

A32030H		• Purified antigen from cell culture• > 50% pure (SDS-PAGE)

A38151H• Purified antigen from human colon
adenocarcinoma cell line
•  95% pure (SDS-PAGE)

		AntigenCD3
CD3 consists of a protein complex with four chains and it isrequired for T-cell activation. CD3 expression can be detected at allstages of T-cell development. Studies have shown that patientswith an unresponsive CD3 receptor have a significantly higher
incidence of recurrent head and neck squamous cell carcinoma.
CD3 is also under investigation as a target for immunosuppressanttherapies for type 1 diabetes and other autoimmune diseases.

Monoclonals• Produced in vivo
MAL66-801

Please note that cell culture derived antigens offer several advantages
over the native fluid versions, including greater availability of the product.

www.MeridianLifeScience.com
www.MeridianLifeScience.com |9 9

Product list | Continued
CD8

CD24

CD8 is a transmembrane glycoprotein that serves as aco-receptor for the T-cell receptor. CD8-positive T-cells represent
a major arm of the cell-mediated anti-tumor response and apromising target for developing T-cell-based immunotherapies
against lung cancer. The chronic presence of lung tumors
induces dysfunctions in CD8-positive T-cells and sensitizes themto activation-induced cell death, which may be associated withpoor clinical responses.

CD24, a heat stable antigen, is a surface marker expressed inmany tumor types. It has been identified as a marker of cancer
stem cells (CSCs) and several studies suggest that CD24-positive
tumors are related to a poor prognosis and for several cancer
types.

Monoclonals• Produced in vivo
MAL08-804

CD13 (Aminopeptidase N)
CD13 is a Zn2+ dependent membrane-bound ectopeptidase that
preferentially degrades proteins and peptides with a N-terminal
neutral amino acid. It has been associated with the growth ofdifferent human cancers and is suggested to be a suitabletarget for anti-cancerous therapy.

Monoclonals• Suitable for use in FC and IHC• Produced in cell culture, biotin conjugatedP01150B

Monoclonals• Recognizes B-cells from pre-B to mature-B stage• Suitable for use in FC and IHC• Produced in vivo, lyophilized
P42118M

CD28
CD28 is one of the proteins expressed on T-cells that provides
co-stimulatory signals required for T-cell activation and survival.
It is also the receptor for CD80 and CD86 proteins. Studies
have shown that it is a marker associated with tumoral
expansion in multiple myeloma.

Monoclonals•	Induces T-cell proliferation in co-stimulation with CD2
monoclonal antibodies• Suitable for use in FC• Produced in vivo
P42235M

CD15
CD15 is a complex cluster of cell surface glycoproteins andglycolipids having a common terminal pentasaccaharide known
as the Lewisx (Lex) antigen. In haematopathology, CD15 isimportant for the diagnosis of classical Hodgkin’s disease andthe characterization of acute leukemia. CD15 may be used forhistopathological grading of gliomas and differentiating between
malignant gliomas and non-neoplastic glial cells. Hepatocellular,
gastric, and colonic carcinoma and thyroid medullary carcinoma
also appear to have worse prognosis if positive for CD15.

Monoclonals• Suitable for use in FC, IHC and IFA• Produced in cell culture
P01158B

1010| Cancer
Cancer && Tumor
Tumor Markers
Markers for- Reagents
Assay Development
for Assay Development

CD30
CD30 is a cell membrane protein of the tumor necrosis factor
receptor family and a tumor marker. CD30 is associated withanaplastic large cell lymphoma. It is expressed in embryonalcarcinoma and on classical Hodgkin Lymphoma Reed-Sternberg
cells. In 2011, the FDA approved an agonistic anti-CD30 drug
conjugate, Brentuximab vedotin, for the treatment for
CD30-positive lymphomas

Monoclonals• Suitable for use in FC, IHC and IFA• Produced in vivo, lyophilized
P42705M

CD37

CD57

CD37 antigen is a transmembrane protein of the tetraspanin
superfamily that is highly expressed on B-cells during the pre-B
to peripheral mature B-cells. In normal tissues, CD37 expression
is restricted to lymphoid tissues. However, CD37 is highly
expressed on malignant B-cells in non-Hodgkin lymphoma andchronic lymphocytic leukemia which suggests that CD37 could
be a promising therapeutic target for B-cell malignancies.

CD57 is a glycoprotein with cell adhesion functions normally
expressed on NK-cells. It serves as a marker of NK cells andneuroendocrine tumors and helps distinguish high grade
prostatic adenocarcinoma (CD57-positive) from high grade
urothelial carcinoma (CD57-negative).

Monoclonals• Suitable for use in ELISA, IHC and IP• Produced in vivo
K8A069M

CD42
CD42 is a cell-surface glycoprotein involved in cell–cellinteractions, cell adhesion and migration. It participates in a wide
variety of cellular functions including lymphocyte activation,
recirculation and homing, hematopoiesis, and tumor metastasis.

Monoclonals• Specific for CD42b• Suitable for use in FC• Produced in vivo, lyophilized
N42409M

Monoclonals• Suitable for use in WB, IHC and FC• Produced in cell culture
P01287M

CD59
CD59 is a glycoprotein expressed on all human peripheral blood
leukocytes, erythrocytes, and several human cell lines. It is apotent inhibitor of the complement membrane attack complex(MAC) action. Its overexpression has been observed in many
types of solid cancers, such as pancreatic cancer and lung cancer.

Monoclonals• Reacts with a well-defined epitope (W40, R-53) on CD59
• Suitable for use in FC and IP• Produced cell culture
MAL59-043

CD66b
CD49d
CD49d is an integrin alpha subunit composed of a β4 (CD49d)
and a β1 (CD29) chain and serves as a receptor for fibronectin
and VCAM-1. It is normally expressed on monocytes, T-cells,
and eosinophils and mainly functions as a cell adhesion andsignaling molecule. In cancer, it is an independent prognostic
marker for disease progression in patients with chronic
lymphocytic leukemia.

Monoclonals• Suitable for use in FC and IFA• Produced in vivo, lyophilized
P42764M

CD66b, also known as carcinoembryonic antigen-related celladhesion molecule 8 (CEACAM8), is expressed mainly on
granulocytes such as a GPI anchored molecule and its mainfunctions are cell adhesion, cell migration, and pathogen
binding. Under normal conditions, neutrophils have minimal
expression of CD66b, however, in chronic myeloid leukemia
its expression is upregulated.

Monoclonals• Suitable for use in FC and IFA• Produced in vivo, FITC labelled
P42531F

www.MeridianLifeScience.com
www.MeridianLifeScience.com |1111

Product list | Continued
CD71

CD147

CD71, the transferrin receptor, is involved in the cellular uptakeof iron and is expressed on cells with high proliferation. Datasuggests that it might be implicated in promoting the growthof endocrine resistance in breast cancer and may serve as aprognostic marker of poor outcome and resistance to tamoxifen.

CD147, an extracellular matrix metalloproteinase inducer,
is correlated with tumor aggressiveness in various humanmalignanciesis including ovarian and gastric cancers. Its
expression is highly associated with cancer invasion andmetastasis and it has the potential to serve as a prognostic
biomarker (e.g. poor outcome).

Monoclonals• Recognizes soluble and bound transferrin receptor• Suitable for use in ELISA and WB• Produced cell culture
H01372M• Suitable for use in ELISA and WB• Produced in vivo
H86602M

CD90
CD90 is a cell surface glycoprotein involved in cell adhesion andcell communication in numerous cell types, but particularly incells of the immune and nervous systems. It is widely used asa marker for hematopoietic stem cells and has been identified
as a valuable marker to differentiate epithelioid mesothelioma
from lung carcinoma. It may also function as a tumor suppressor
in nasopharyngeal carcinoma.

Monoclonals• Suitable for use in WB, IFA, FC, and IP• Produced in cell culture
P01283M

CD105 (Endoglin)
CD105 is an accessory protein of the transforming growth
factor-beta receptor system and is expressed on vascularendothelial cells. Studies have identified CD105 expression
in several solid tumor types, with the level of expression
correlating to various clinicopathologic factors including
decreased survival and presence of metastases. It is anindependent predictive marker for death risk and unflavorable
prognosis in patients with renal cell carcinoma.

Monoclonals• Suitable for use in WB, IP and FC• Produced in vivo
MAL105-226

1212| Cancer
Cancer&&Tumor
TumorMarkers
Markersfor- Reagents
Assay Development
for Assay Development

Monoclonals• Recognizes an epitope in the N-terminal Ig domain (D1)
• Suitable for use in FC• Produced in vivo
P87535M* Also works in WB and IP

CD177
CD177 is an important membrane glycoprotein on neutrophils
and serves as a marker for myeloproliferative diseases. Loss of
CD177 expression is linked to higher metastasis incidence andshorter survival in breast cancer patients.

Monoclonals• Suitable for use in WB, FC and IP• Produced in vivo
MAL177-166

CD195 (CCR5)
CD195 is a protein on the surface of white blood cells thatis involved in the immune system and it acts as a receptor forchemokines, specifically CCL3 (MIP1α), CCL4 (MIP1β) and CCL5
(RANTES). It is also used by HIV (along with CXCR4) to entertarget cells. CD195 has been implicated to play a role in themetastasis of breast cancer and colorectal cancer.

Monoclonals• Suitable for use in FC• Produced cell culture
P01240M

Centromere Protein B (CENPB)

Cyfra 21-1, Cytokeratin 19 Fragment

CENPB is a highly conserved DNA protein that facilitates
centromere formation. It is used as a serologic marker for
autoimmune diseases, specifically sclerosis and otherrheumatic conditions. It is also a potential biomarker ofsmall-cell lung cancer and a prognostic marker for breast
cancer (indicating prolonged survival).

Cyfra 21-1 is a sensitive and specific tumor marker of lungcancer, especially of the squamous cell subtype. An assay for
Cyfra 21-1 was first approved by the FDA in 2011 to monitor
disease progression and treatment of lung cancer patients. It isalso reported to be a potential biomarker for ovarian cancer.

Antigens
A01375H
				• Recombinant (Sf9 Insect Cells)• Suitable for use in ELISA and WB• > 95% pure (SDS-PAGE)

R01646
				• Recombinant (Sf9 Insect Cells)• Suitable for use in ELISA and WB• 90% pure (SDS-PAGE)

c-Myc

Monoclonals• Produced in vivo
MAB07-510 * Suitable for use in WB and IHC

Collagen Type VI
Collagen Type VI is a widely distributed extracellular matrix
macromolecule that plays a crucial role in tissue development
and is highly expressed in cancers. Studies show that it
promotes chemotherapy resistance, and specifically in breast
cancer it regulates cancer progression and metastasis.

Antigens
A32340H				• Native antigen from MCF-7 Cell Supernatant• Calibrator Grade with low cross-reactivity• Suitable for use in CLIA

Human defensins are small cationic peptides produced byneutrophils and epithelial cells and they form two geneticallydistinct alpha and beta subfamilies. Defensins are involved invarious aspects of the innate and acquired immune responses
and recently, single nucleotide polymorphisms of beta-defensins
have been correlated with increased susceptibility to cancer.
Specifically, in oral cancer beta-defensins are down-regulated
indicating that it may play a role in tumor suppression.

Monoclonals• Suitable for use in ELISA• Produced in cell culture, lyophilized
			 EPITOPE BINDING
P24141M
a.a. 1-36, Defensin-beta 1 * Also works in WB
P24011M
a.a. 4-41, Defensin-beta 2

Antigens
A24100H

Antigens		• Suitable for use in ELISA• Produced in vivo
M01300M

Defensin-betac-Myc a multifunctional, nuclear phosphoprotein that plays a rolein cell cycle progression, apoptosis and cellular transformation.
A mutated version causing consituative expression of c-Myc isfound in many cancers, including Burkitt lymphoma the cervical,
ovarian, colon, breast, lung and stomach cancers.

A33129H
		

Monoclonals• Native antigen from human placental villi• Suitable for use as a standard, or for antibody
production• > 90% pure (SDS-PAGE)		
A24601H
		• Synthetic peptide representing a.a. 4-41
(Defensin-beta 2)• > 95% pure (HPLC), lyophilized• Synthetic peptide representing a.a. 3-39
(Defensin-beta 4)• > 95% pure (HPLC), lyophilized

www.MeridianLifeScience.com
www.MeridianLifeScience.com |1313

Product list | Continued
DesminEpidermal Growth Factor Receptor (EGFR)

Desmin is a type III intermediate filament in smooth muscle
tissue and has a wide variety of functions. Several studies haveshown that desmin is a highly sensitive marker for endothelial
cell differentiation and tumor invasiveness in several types ofcancers, including colon cancer, gastrointestinal stromal tumors,and embryonal sarcoma.

EGF is a growth factor that stimulates cell growth, proliferation,and differentiation by binding to its receptor EGFR. Dysregulationof EGF and mutations that lead to EGFR overexpression havebeen associated with a number of cancers, including lung, breast
and anal cancers as well as glioblastoma multiforme. Many
therapeutic approaches are aimed at the EGFR such as
cetuximab and panitumumab.

Monoclonals

Monoclonals• Produced in vivo
MAM26-014• Suitable for use in ELISA (unless stated otherwise)• Lyophilized• Produced in cell culture (unless stated otherwise)
K67138M* Recognizes the C-terminus a.a. 1165-1186, also works in IB,

Disialoganglioside GD2Disialoganglioside GD2 is a sialic-acid bearing glycolipid that isexpressed on the surface of all mammalian cells. Studies haveshown that they are important target antigens for antibody
dependent cellular cytotoxicity of human melanoma andneuroblastoma cells. The relatively tumor-specific expressionof GD2 makes it a suitable target for immunotherapy withmonoclonal antibodies or with artificial T-cell receptors.

Antigens
A86168H
		• Native antigen from human brain• > 98% pure (HPTLC), lyophilized

Elastase
Elastase is a serine proteinase and specifically the neutrophil
form of Elastase is 218 amino acids long, with two asparaginelinked carbohydrate chains. It is secreted by neutrophils andmacrophages during inflammation to destroy bacteria and hosttissue. Research has shown that neutrophil Elastase can speed
up the progression of cancer and the amount of immunoreactive
neutrophil Elastase in tumor tissue is an independent prognostic
indicator of patients with breast cancer and lung cancer.

Antigens
A01683H
				• Native antigen from human neutrophils• Suitable for use in ELISA and WB• 90% pure SDS-PAGE (Chromatography)

A50145H
		• Native antigen from human neutrophils• > 95% pure (SDS-PAGE), lyophilized

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K90052C

Sheep

Purified

WB

1414| Cancer
Cancer&&Tumor
TumorMarkers
Markersfor- Reagents
Assay Development
for Assay Development

ICC and IP

P24100M
P24200M
K67190M* Does not cross-react with v-erb-B, also works in IHC and FC

K67902M* Recognizes site phosphorylated at Tyrosine 1173, also works
in IB, ICC and IP

K67123M* Recognizes site phosphorylated at Tyrosine 845, also works
in IB* Does not cross-react with v-erb-B, also works in IHC and FC* Recognizes site phosphorylated at Serine 1047, also works
in IB, ICC and IP

Antigens
VTI880				• Recombinant EGF (P. pastoris)• Suitable for use in WB• 95% pure (SDS-PAGE)

VTI882				• Recombinant EGF (P. pastoris)• Suitable for use in WB• > 95% pure (SDS-PAGE)

erbB-2, HER2/neu

Factor H (Beta 1H)

Receptor tyrosine-protein kinase erbB-2 also frequently
called HER2 (human epidermal growth factor receptor 2) isa member of the human epidermal growth factor receptor
family. Overexpression of HER2 plays an important role in thedevelopment and progression of certain aggressive types ofbreast cancer. Approximately 15% of all newly diagnosed breast
cancers are HER2-positive and the purpose of HER2 testing is to
identify patients who could benefit from effective HER2-targeted
therapies, such as trastuzumab (Herceptin), lapatinib (Tykerb),
pertuzumab (Perjeta), and T-DM1 (Kadcylapatients).

Factor H is a member of the regulators of the complement
activation family and is a complement control protein. There are
a number of clinical implications arising from aberrant factor H
activity including stroke, schizophrenia and cancer. Specifically,it has been identified as a tumor marker for bladder cancer.

Monoclonals• Reacts with peptide ILDV4• Suitable for use in ELISA• Produced in vivo
M01296M* Reacts with peptide ILDV4 (dephosphorylated)
M01297M* Reacts with peptide ILDV4 (phosphorylated)
M01298M* Reacts with peptide ILDV2 (dephosphorylated)
M01299M* Reacts with peptide ILDV2 (phosphorylated)

Antigens
R01605				• Recombinant (HEK293 cells)• Suitable for use in ELISA•  95% Pure (SDS-PAGE), lyophilized, contains
a His-tag

Epithelial Cell Adhesion Molecule (EpCAM)
EpCAM is a glycoprotein involved in cell-cell adhesion, signaling,cell migration, proliferation, and differentiation. Its expression isrestricted to normal epithelial cells in healthy individuals but incancer, its expression distribution varies depending on the typeof carcinoma. It is considered a tumor-associated antigen andmay act as a potential prognostic marker for various cancers.

Monoclonals• Suitable for use in ELISA and WB• Produced in vivo
M01310M* Recognizes a.a. 116-242

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K90030C

Sheep

Purified

DD,IE,IEP

Factor VIII (FVIII)FVIII is an essential blood-clotting protein, also known asanti-hemophilic factor. Inhibitors to FVIII develop in malignancies
which can lead to an acquired hemophilic state and an increased
risk for deep vein thrombosis and pulmonary embolism.

Monoclonals•	Antibody binds human factor VIII A2 domain in
immunoblotting techniques• Suitable for use in ELISA and WB
N01277M

Glyceraldehyde-3-Phosphate
Dehydrogenase (GAPDH)GAPDH catalyzes the conversion of glyceraldehyde-3-phosphate
to D-glycerate 1,3-bisphosphate which is the 6th step in theprocess of glycolysis. It is overexpressed in multiple humancancers, such as cutaneous melanoma, and its expression ispositively correlated with tumor progression. It has also been
implicated in several neurodegenerative diseases and disorders.

Monoclonals• Suitable for use in ELISA and WB• Produced in vivo, HRP conjugatedH86045P
H86504P* Reacts with monomeric and dimeric forms (not tetramericform), also works in IFA and ICC

Antibody Pairs• Suitable for use in ELISA• Produced in vivo
CAPTURE
DETECTION
H86504M

H86045M

H86504M

H86903M* Reacts with monomeric and dimericforms (not tetrameric form), also
works in WB

www.MeridianLifeScience.com
www.MeridianLifeScience.com |1515

Product list | Continued
Heat Shock Proteins

Human Epididymis Protein 4 (HE4)Heat shock proteins are involved in protein folding, stability,transport and transcriptional regulation. They are also known
to participate in many pathological processes, such as asthma,
intimal hyperplasia, and insulin resistance. In addition they havea cytoprotective role and are essential for cancer cell survival
and are often upregulated in cancer. Specifically, HSP20 may
have value as a prognostic tumor marker for colorectal cancerand HSP27 as a prognostic marker of prostate cancer.

HE4 belongs to the family of whey acidic four-disulfide coreproteins and currently, the biologic function of HE4 is unknown.
Expression of HE4 is found in the glandular epithelium of the
reproductive tract, distal renal tubules, and respiratory
epithelium. In cancer, the highest serum levels of HE4 are foundin epithelial cancer, serous ovarian cancer and endometrioid
cancer. The main established application of HE4 is in posttherapy monitoring of ovarian cancer patients who had elevatedpretreatment levels with little or no expression of CA125.

Monoclonals• Suitable for use in ELISA, WB and IFA• Produced in vivo
H86201M* Recognizes human recombinant HSP20 and HSP20 fromhuman cardiac tissue

Hemoglobin
Hemoglobin is the iron-containing metalloprotein in red blood cells
that transports oxygen. In diseases related to gastrointestinal
bleeding such as colorectal cancer, hemoglobin is leaked into
gastrointestinal tract and then discharged with the feces. Fecal
occult blood tests (FOBT) are the specific name for assays that
detect blood in the stool. Many commercial assays are ELISA orlateral flow based antigen detection assays that use antibodies
specific to hemoglobin.

Antibody Pairs• Suitable for use in ELISA• Produced in vivo
CAPTURE
DETECTION
M01323M
M01323M
M01323M

M01320M
M01321M
M01322M

Antigens
A01469H
		• Native antigen from human epididymis cell line
• Suitable for use in CLIA

A01466H
				• Native antigen from human fluids• Suitable for use in CLIA
• 90% Pure (SDS-PAGE)

Antibody Pairs• Suitable for use in ELISACAPTURE
DETECTION
H01417M

H01416M

Insulin Like Growth Factor I(IGF-I or Somatomedin C)*Hemoglobin• MAb to Hemoglobin (FOB)• Recognizes Human Hemoglobin• Suitable for use in Lateral Flow and Turbidimetry (Latex)
CAPTURE
DETECTION
H01409M

H01410M

Antigens
A01703N		

IGF-I is a peptide hormone involved in regulating human growthand development and is similar in molecular structure to insulin.
It is produced primarily by the liver as an endocrine hormone
and is a strong mitogen for a wide variety of cancer cell lines,
including sarcoma, leukemia, and cancers of the prostate,breast, lung, colon, stomach, esophagus, liver, pancreas, kidney,
thyroid, brain, ovary, and uterus (both cervical and endometrial).

Monoclonals• Suitable for use in LF• Purified, Liquid1616| Cancer
Cancer && Tumor
Tumor Markers
Markers for- Reagents
Assay Development
for Assay Development• Suitable for use in ELISA and RIA• Produced in cell culture
E54061M

Insulin Like Growth Factor Binding Protein 3(IGFBP-3)

Interleukin 1 alpha (IL-1a) andInterleukin 1 Receptor (IL-1R)

IGFBP-3 is a transporter protein produced in the liver that isthought to regulate growth through its main binding protein
Insulin-like growth factor-1 (IGF-1). High circulating concentrationsof IGF-I are associated with an increased risk of cancer (especiallybreast cancer), whereas IGFBP-3 concentrations are associatedwith a decreased cancer risk.

IL-1a is a pleiotropic cytokine that is localized in the cytosolor cell membrane and is believed to regulate the intracellularenvironment. Its receptor is IL-1R and it is responsible formediating its effects. It is known to be upregulated in manytumor types and has been implicated as a factor in tumor
progression via the expression of metastatic and angiogenic
genes and growth factors.

Antibody Pairs• Suitable for use in CLIA, ELISA and RIA• Recognizes native and recombinant Human IGFBP-3
CAPTURE
DETECTION
K01411M

K01410M

Integrin alpha M (CD11b/MAC-1)
The Integrin alpha M subunit, also known as MAC-1 alphasubunit or CD11b, combines with the integrin beta 2 subunit(CD18) to form the non-covalent heterodimer integrin alphaM/beta 2, also known as the MAC-1 receptor. Integrin alpha M
has been suggested to be an independent prognostic factor ofgastric cancer patients, as well as lymph node metastasis andtumor size.

Monoclonals• Produced in vivo, FITC labelled
P42530F

Antigens
A42201H		

Lactate Dehydrogenase (LDH)
LDH is an enzyme composed of four subunits that catalyzes theconversion of lactate to pyruvic acid. It is released during tissue
damage and is involved in tumor initiation and metabolism.
Studies have shown differential expression between the LDH
isoenzymes and overall, LDH expression can act as a generalmarker in the prognosis of cancers. Specifically expressionof LDH-5 in tumors and the stroma has been found to be astrong prognostic factor for diffuse or mixed-type gastric cancers.

Antigens
A38357H
				Interferon gamma (IFN-gamma)
IFN-gamma is a cytokine that plays physiologically importantroles in promoting innate and adaptive immune responses.
In cancer, it has been shown to prevent the development ofprimary tumors, regulate tumor growth and to promote thehost response to tumor.

A38155H
				
A38252H
		

Monoclonals• Suitable for use in ELISA• Produced in vivo
P18442M* Neutralizing antibody, lyophilized
P86424M* Also works in WB

		

Antibody Pairs

		• Suitable for use in ELISA and WB• Produced in vivo
CAPTURE
DETECTION

A38454H
		

P86842M

P01309M• Recombinant IL-1a (E. coli)• > 97% pure (HPLC and SDS-PAGE), lyophilized

A38353H
				
A38558H
				• Native LDH sources from human heart• Specific Activity: 260 Units/mg protein(lot dependent)• Purified by ammonium sulfate precipitation• Native LDH1 from human erythrocytes• Specific Activity: 125 Units/mg protein(lot dependent)• Ammonia sulfate suspension• Native LDH2 from human erythrocytes• Specific Activity: 300 Units/mg protein(lot dependent)• Ammonia sulfate suspension• Native LDH3 from human erythrocytes• Specific Activity: 240 Units/mg protein(lot dependent)• Ammonia sulfate suspension• Native LDH4 from human erythrocytes• Specific Activity: 220 Units/mg protein(lot dependent)• Ammonia sulfate suspension• Native LDH5 from human erythrocytes• Specific Activity: 460 Units/mg protein(lot dependent)• Ammonia sulfate suspension
www.MeridianLifeScience.com
www.MeridianLifeScience.com |1717

Product list | Continued
Lamin

Lysozyme

Lamins are the major component of the nuclear lamina withseveral functions including structural support of the nucleus,
facilitating chromatin organization, gene regulation and DNA
repair. They are often aberrantly expressed or localized intumors and they are suggested to be a marker of good or poor
patient survival depending on tumor subtype. In prostatecancer, lamins are specifically involved in cell proliferation,
migration and invasion.

Lysozymes are enzymes that damage bacterial cell walls andthey can be found in a number of secretions, such as tears,
saliva, human milk, and mucus. In certain cancers (especially
myelomonocytic leukemia) excessive production of lysozyme
by cancer cells can lead to toxic levels of lysozyme in the blood
leading to kidney failure and low blood potassium.

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

T24210R

RabbitPurified

IHC,WB

T24210R is specific for Lamin 5

Antigens
A24210H				• Native Lamin 5 from human foreskinkeratinocytes• Suitable for use in WB• > 95% pure (SDS-PAGE)

LeptinA01399H
		• Recombinant (rice seed)• 90% pure (SDS-PAGE), lyophilized

Microtubule Associated Protein 2 (MAP-2)
MAP-2 is a protein involved in microtubule assembly, anessential step in neuritogenesis. Accumulating evidence showsthat changes in the expression or post-translational modificationof MAPs can contribute to the dysregulation of microtubule
dynamics and consequently lead to the development of serious
diseases, including cancer. MAP-2 has specifically been
implicated to play a role in oral cancer.

Monoclonals

Leptin is a hormone made by adipose cells that helps to regulateenergy balance by inhibiting hunger and regulating of fat stores.
In the context of cancer, leptin expression can be induced underhypoxic conditions which often occurs in solid tumors. Leptin
expression is upregulated in several types of cancer including
breast, colorectal, prostate, ovarian, and lung cancer.

Monoclonals• Suitable for use in IHC and ELISA• Produced in vivo
H4A342M* Reacts with C-terminal, a.a. 92-145

Antigens
A42327H
		

Antigens• Recombinant (E. coli)• > 95% pure (RP-HPLC and SDS-PAGE),
lyophilized

1818| Cancer
Cancer && Tumor
Tumor Markers
Markers for- Reagents
Assay Development
for Assay Development• Reacts with high molecular weight forms of MAP-2 (2a&2b)• Suitable for use in WB and IHC (unless noted otherwise)• Produced in cell culture
Q01119M

Mast Cell Tryptase (MCT)MCT is considered to be an important marker of mast cell
activation as well as an important mediator of inflammation
and angiogenesis. It plays a role in pancreatic cancer
angiogenesis and tumor growth and in breast cancer invasion
and migration.

Monoclonals• Recognizes alpha and beta isoforms of MCT• Suitable for use in ELISA, WB and IHC• Produced in cell cultureH01317M

Monocyte Chemotactic Protein 1 (MCP-1 or CCL2)
MCP-1 is a small cytokine that recruits monocytes, memory
T-cells, and dendritic cells to the sites of inflammation producedby either tissue injury or infection. Increased MCP-1 serum
levels have been seen in patients with various cancers andhas been suggested to be a prognostic marker for solid tumors. It
may also be a helpful tumor marker of prognosis in patients withdigestive cancer, urogenital cancers, and head and neck cancers.

Antigens
A01251H		• Recombinant (E. coli)• > 98% pure (RP-HPLC & SDS-PAGE), lyophilized

CAPTURE

DETECTION

M86520M
M86406M
M86416M
M86141M
M86101M

M86101M
M86101M
M86101M
M86201M
M86520M

Antigens
A86803H
						• Native antigen from human brain• Subunit composition is gamma-gamma• Suitable for use in ELISA• > 95% pure (SDS-PAGE)

A01359H				

NGAL is a secreted carrier protein that acts in the innate immune
response and is used as a biomarker of kidney injury. It alsofunctions as a growth factor and is highly expressed in earlydysplastic lesions in the pancreas, suggesting a possible role asan early diagnostic marker for pancreatic cancer. In addition,
serum NGAL might be a possible biomarker in pancreatitis
and pancreatic adenocarcinoma.

		• Recombinant (E. coli)• Represents a.a. 2-434, contains a His-tag• Suitable for use in ELISA, LF, WB, DB,
and IHC• > 95% pure (SDS-PAGE)

A01448H
						• Recombinant (E. coli)• Represents a.a. 1-434, contains a His-tag• Suitable for use in ELISA• 95% pure (SDS-PAGE)

Polyclonals

Osteopontin (OPN)

Neutrophil Gelatinase-Associated Lipocalin(NGAL)/Lipocalin-2

CATALOG

SOURCEFORMATAPPLICATION

K01392C

C. Eggs

Aff.Pur.

N/A

Antigens
9278
		
		

• Recombinant (CHO cells)• Suitable for use in WB• 95% pure (SDS-PAGE)

OPN is an extracellular matrix protein involved in the regulationof normal mineralization in bone and teeth and is an importantfactor in bone remodeling. Various human cancers, including
breast cancer, have been observed to express splice variants of
OPN. Studies have shown that it is significantly associatedwith survival in several forms of cancer, suggesting its value asa clinical marker of tumor progression.

Monoclonals

Neuron Specific Enolase (NSE) gamma
NSE is a glycolytic enzyme that catalyzes the conversion ofphosphoglycerate to phosphoenol pyruvate and is the dominantenolase-isoenzyme found in neuronal and neuroendocrine
tissues. NSE can be used to monitor disease progression andmanagement in small cell lung cancer, and as an independent
predictor of survival of non-small cell lung cancer.

Antibody Pairs•	Specific for the gamma subunit, no cross-reactivity withalpha or beta subunits• Suitable for use in ELISA• Produced in vivo

• Specific to N-terminal (a.a. 1-166)• Suitable for use in ELISA and WB• Produced in vivo
M66102M

Antibody Pairs• Suitable for use in ELISA and WB• Produced in vivo
CAPTURE
DETECTION
M66103M

M66105M

www.MeridianLifeScience.com
www.MeridianLifeScience.com |1919

Product list | Continued
Pepsinogen I and Pepsinogen II (Pepsinogen C)

Prolactin (PRL)

Pepsinogen is a precursor of pepsin, a protease secreted in thestomach, and is immunologically categorized into two mainclasses, Pepsinogen I and Pepsinogen II. Serum Pepsinogen I/II
ratio is widely used for the screening of gastric cancer andatrophic gastritis.

PRL is luteotropic hormone that plays an essential role inmetabolism, regulation of the immune system, pancreaticdevelopment and lactation. It is synthesized and secreted
in the anterior pituitary gland, breast tissue and decidua. A
prolactin-secreting pituitary tumor is the most frequent causeof hyperprolactinemia which is associated with increased riskof breast cancer.

Antibody Pairs• Recognizes Pepsinogen I• Suitable for use in ELISA and Lateral FlowCAPTURE
DETECTION
K01402M
K01406M

K01402M
K01407M• Recognizes Pepsinogen II• Suitable for use in ELISA and Lateral Flow.
CAPTURE
DETECTION
K01404M

K01404M

Antigens
A01420H				• Suitable for use in ELISA• Produced in vivo
CAPTURE
DETECTION
E20122M
E20630M
MAF10-111
MAF10-111
MAF10-216

E20630M
E20122M
MAF10-145
MAF10-710
MAF10-245

Antigens• Native Pepsinogen II antigen• Suitable for use in WB• > 90% pure (SDS-PAGE), lyophilized

A01274H
		• Recombinant (P. pastoris)• > 96% Pure (SDS-PAGE), lyophilized

Prostate Secretory Protein (PSP)PIVKA-IIProtein Induced by Vitamin K Absence or antagonist-II (PIVKA-II)
has been shown to be a useful marker for the diagnosis ofhepatocellular carcinoma (HCC), especially when combined withalpha-fetoprotein (AFP), which is the most commonly usedtumor marker for HCC. Overall, assays detecting both PIVKA-II
and AFP have been shown to achieve a sensitivity andspecificity 94% and 98.5%, respectively.

Antibody Pairs•	Suitable for use in ELISA•	Cross reactivity:- Prothrombin <0.001%- Thrombin <0.001%•	Developed using a proprietary synthetic immunogen
CAPTURE
DETECTION
M01344M

Antibody Pairs

M01343M

2020| Cancer
Cancer && Tumor
Tumor Markers
Markers for- Reagents
Assay Development
for Assay Development

PSP is inhibin-like protein and one of the major secretory
proteins of the prostate glands. It is postulated to play a role incancer growth regulation and induction of apoptosis in prostatecancer cells. Low levels of PSP are associated with advanced
prostate cancer.

Monoclonals• Suitable for use in ELISA, WB and IHC• Produced in vivo, lyophilized
M14248M

Prostate Specific Antigen (PSA)
PSA is a protease that makes semen more liquid by breaking
down the high molecular weight protein of the seminal coagulum
into smaller polypeptides. It exists in serum in multiple forms:
complexed to alpha-1-anti-chymotrypsin (PSA-ACT complex),unbound (free PSA), and enveloped by alpha-2-macroglobulin. In
men with prostate cancer or other prostate disorders, PSA levels
are elevated and higher total PSA levels and lower percentagesof free PSA are associated with higher risks of prostate cancer.
The FDA first approved PSA as a screening assay for prostatecancer in the early 1990s.

Prostate Specific Antigen (PSA) continued
Monoclonals

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K31302G

Goat

Aff.Pur.

N/A• Suitable for use in ELISA (unless otherwise noted)• Produced in vivo
M01256M* Reacts with PSA/ACT complex and free PSA
M92396P* Reacts with total PSA, HRP conjugated
MAM07-234 * Only works in IHC

Antigens
A01444H
				• Native PSA from human seminal plasma• Suitable for use in ELISA• 96% PSA (SDS-PAGE)

Total PSA (Free PSA and PSA complexed with ACT)

A86878H
				• Native PSA from human seminal fluid• Suitable for use in ELISA, as an immunogenfor antisera product or as a tracer for iodination• >98% PSA (SDS-PAGE), lyophilized

A01368H
				• Native PSA from human seminal fluid• Suitable for use in ELISA• >95% PSA (SDS-PAGE), lyophilized

A31029H• Native PSA/ACT Complex from human seminal
fluid and human plasma• >95% PSA (SDS-PAGE)

Antibody Pairs• Suitable for use in ELISA• Produced in vivo
• All antibodies are MAbs unless otherwise noted
CAPTURE
DETECTION
M86599M
M01236M
M66276M
M66279M
M66280M
M66276M
M66280M
M66279M
M66280M
M66280M
M66280M
M66278M
M66281M
M86506M

M86506M
M86506M
M86506M
M86506M
M86506M
M66280M
M66276M
M66280M
M66279M
M66278M
M66281M
M66280M
M66280M
M86209M* Also works in LF* Also works in LF

		A75029H

Antibody Pairs• Suitable for use in ELISA• Produced in vivo
• All antibodies are MAbs (unless otherwise noted)
CAPTURE
DETECTION
M92396M
M86506M
M86806M
M86806M
M86806M
M86806M
M86806M
M86343M
M86433M

A01387H
				• Native PSA from human seminal fluid• High pI Isoform• >96% PSA (SDS-PAGE)

A01238H
		• Native PSA from human seminal fluid• 96% pure (SDS-PAGE)

Retinol Binding Protein 4 (RBP4)

Free PSA

M92986M
M86806M
M86506M
M86209M
M66278M
M66280M
M66281M
M86433M
M86343M

		• Native PSA/ACT Complex from human seminal
fluid and human plasma• >99% PSA (SDS-PAGE)* Also works in LF* Also works in LF

RBP4 is an adipokine and is the specific carrier for retinol (vitamin
A alcohol) in the blood. It is secreted by adipocytes and has beenshown to potentially have a causative effect on the developmentof insulin resistance. In epithelial ovarian cancer, RBP4 has beensuggested as a candidate diagnostic or prognostic biomarker.

Antibody Pairs•	Recognizes free RBP4 and RBP4/ transthyretin complex• Reacts with apo-RBP4 and holo-RBP4• Suitable for use in ELISA and WB (reducing conditions)• Produced in vivo
CAPTURE
DETECTION
E01269M
E01269M
E01265M

E01268M
E01267M
E01270M

www.MeridianLifeScience.com
www.MeridianLifeScience.com |2121

Product list | Continued
S-100

Serum Amyloid A (SAA)The S-100 family of proteins are involved in the regulation of anumber of cellular processes including cell cycle progression anddifferentiation. Dysregulated expression of several S100 proteinsis a common feature of human cancers, with each type of cancer
showing a unique S100 protein profile. S-100 is suggested to bea diagnostic marker for differentiating amelanotic malignant
melanomas end may also aid the detection of micrometastatic
disease in the lymph nodes of melanoma patients.

SAA is a sensitive marker of acute inflammation that is
synthesized under the regulation of inflammatory cytokines
during both acute and chronic inflammation. Increases in serum
levels of SAA correlate with many types of carcinogenesis andneoplastic diseases. Specifically SAA has been suggested to bea potential tumor marker for renal cancer, lung cancer anduterine cervical cancer.

Monoclonals• Produced in vivo
MEM24-211 * Works in IHC
Q86403M* Recognizes S-100 (beta-beta) and S-100 (alpha-beta),
works in WB• Suitable for use in ELISA and IP• MAbs produced in vivo
CAPTURE
DETECTION
Q86006M

Q86610M* Specific for S-100 beta-beta andalpha-beta

Q86003M

Q86610M* Specific for S-100 beta-beta

Antigens

				
A86289H
				• Recognizes native and recombinant human SAA• Suitable for use in ELISA and WB• MAbs produced in vivo
CAPTURE
DETECTION
H01381M
H01382M

Antibody Pairs

A86809H		

Antibody Pairs• Native antigen from human brain• Contains beta-beta homodimer (S-100b) andalpha-beta heterodimer (S-100a)• Suitable for ELISA, for antibody production oras tracer for iodination• > 95% pure, lyophilized• Native S-100b homodimer from human brain• Suitable for ELISA, for antibody production oras tracer for iodination• > 95% pure, lyophilized

H01383M
H01384M

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

H01379R

RabbitPurified

ELISA,IEP

Antigens
R01619				• Recombinant (E. coli)• 122 a.a. long with N-terminal His tag• Suitable for use in ELISA

Sialyl Lewis A and Sialyl Lewis X
Lewis blood group antigens are biosynthetically andstructurally related carbohydrate structures used as markers ofcell differentiation and embryonic development. Sialyl Lewis A
and Sialyl Lewis X are specifically tumor-associated andinvolved in adhesion and metastatic potential of cancer cells.
They are being used to identify new cancer biomarkers
through antibody arrays paired with a glycan specific antibody
to probe the bound glycoproteins, in identifying new ways totarget cancer cells for therapy.

Monoclonals• Produced in vivo
MAM10-810 * Specific for Sialyl Lewis A
MEM11-767 * Specific for Sialyl Lewis X

2222| Cancer
Cancer && Tumor
Tumor Markers
Markers for- Reagents
Assay Development
for Assay Development

Superoxide Dismutase (SOD)
SODs are a group of metalloenzymes (containing Fe, Mn, or Cu
and Zn) that are an important antioxidant defense in all living
cells. Many human tumors have shown significant changes in
the activity and expression of SODs. The ratio of MnSOD to
CuZnSOD activity has been suggested as a potential biomarker
for gastric adenocarcinoma.

Monoclonals• Specific for Cu/Zn SOD• Suitable for use in ELISA and WB• Produced in vivo
H86141M

Thymus and Activation Regulated
Chemokine (TARC)
TARC is a small CC chemokine that is constitutively expressed in
the thymus. It is known to play an important role in Th2-mediatedimmune-inflammatory processes. Aberrant TARC expression isobserved in many diseases including cancer, autoimmune
disorders, and atherosclerosis. Serum TARC is a promising serum
biomarker for gastric cancer and induces metastasis of breast
cancer cells.

Antigens
A28330H
		• Recombinant (E. coli)• >97% pure (SDS-PAGE and HPLC analysis),lyophilized

Thyroid Peroxidase (TPO)
TPO is a membrane thyroid enzyme essential for thyroid
hormone synthesis and it is present in large quantities in thecytoplasm of normal thyrocytes. In malignant tumors, TPO
synthesis is inhibited to varying degrees and maturation isderegulated resulting in overexpression of short splice variants.
It has diagnostic utility as a tumor marker in thyroid cancer.

Monoclonals•	Can be used for affinity purification of human TPO•	Produced in vivo
E86415M

Antibody Pairs• Suitable for use in ELISA• Produced in vivo
CAPTURE
DETECTION
E01311M
E01310M

E01309M
E01309M

Antigens
A01309H
				• Recombinant (Baculovirus), a.a. 19-846• Suitable for use in ELISA and WB• 95% pure (SDS-PAGE), lyophilized

Thyroglobulin (Tg)Thyroglobulin is a dimeric protein produced by the follicular
cells of the thyroid and is the precursor of thyroid hormones
thyroxine (T4) and triiodothyronine (T3). It is an FDA approved
tumor marker to evaluate the effectiveness of treatment fordifferentiated thyroid cancer and to monitor for recurrence.

Antibody Pairs• Suitable for use in ELISA• Produced in vivo
CAPTURE
DETECTION
E01326M

E01325M

Antigens
A86852H				• Native antigen from human thyroid• Suitable for use as a standard, for antibody
production or as a tracer for iodination• > 90% pure (SDS-PAGE), lyophilized

Tissue Transglutaminase (tTG)
tTG is a calcium-dependent enzyme which catalyzes the
crosslinking of proteins and plays a role in apoptosis, celladhesion, metastasis, and extracellular matrix assembly. tTG isparticularly notable for being the autoantigen in coeliac disease
and has also shown to play a role in regulating tumor growthand metastasis in breast cancer.

Antigens
A01363H
				
R01650				• Recombinant (HEK-293-EBNA cells)• Suitable for use in ELISA• 95% pure (SDS-PAGE), lyophilized• Recombinant (Sf-21 Insect Cells)• Suitable for use in ELISA• 90% Pure (SDS-PAGE)

www.MeridianLifeScience.com
www.MeridianLifeScience.com |2323

Product list | Continued
Trypsin

Vitronectin

Trypsin is a serine protease family member found in thedigestive system where it hydrolyses proteins. It is expressedby many tumors and plays a significant role in tumor invasion,
especially in stomach cancer cells. Elevated expression oftrypsin in colorectal cancer also correlates with unfavorable
clinicopathological characteristics and shortened survival.

Vitronectin is a glycoprotein that regulates proteolysis initiated byplasminogen and is involved in hemostasis. Studies haveshown that serum levels of Vitronectin are correlated with tumor
size, and clinical stage suggesting that it could serve as apromising serum marker for the early diagnosis of breast cancer.

Antigens
A50188H
		• Native antigen from human pancreas• > 95% pure (SDS-PAGE), lyophilized

Tumor Necrosis Factor alpha (TNF-alpha)
TNF-alpha is a cytokine produced by activated macrophages andis involved in the regulation of immune cells. Dysregulation of
TNF production has been implicated in a variety of diseases
including cancer, Alzheimer’s, Psoriasis, and inflammatory bowel
disease. In breast cancer, high TNF-alpha serum concentrations
correlate with late-stage breast tumor phenotypes suggestinga role of TNF-alpha as a breast cancer marker.

Antibody Pairs• Suitable for use in ELISA, IHC and neutralization• Produced in vivo
CAPTURE
DETECTION
H86410M

H86650M

Urokinase (uPA)uPA is a serine protease used clinically as a thrombolytic agent
in the treatment of severe or massive deep venous thrombosis,
pulmonary embolism, and myocardial infarction. Substantial
evidence implicates uPA, urokinase plasminogen activator
receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) in
the neo-vascularization, invasion and metastasis of many solid
tumors. Clinical studies have demonstrated an association
between high levels of expression of this system in tumors andpoor patient prognosis and outcome.

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K63819R

RabbitPurified

ELISA,IHC,WB

2424| Cancer
Cancer && Tumor
Tumor Markers
Markers for- Reagents
Assay Development
for Assay Development

Monoclonals• Suitable for use in ELISA and IB• Produced in cell culture
N77810M

Polyclonals
CATALOG

SOURCEFORMATAPPLICATION

K63964R

RabbitPurified

ELISA,WB

Antigens
A63731H		• Native antigen from human plasma• > 95% pure (SDS-PAGE)

www.MeridianLifeScience.com

25Meridian Life Science, Inc.
5171 Wilfong Road | Memphis, TN 38134
901.382.8716 • 800.327.6299
www.MeridianLifeScience.com

Connect with us:

10/21