Yuichiro AIBA, Ph. D. (Associate Professor)
Affiliation:

Department of Chemistry, Graduate School of Science,
Nagoya University

Address:

SA601, Furo-cho, Chikusa-ku, Nagoya, 464-8602, Japan
Phone: +81-52-789-2953、Fax: 052-789-3557

E-mail:aiba.yuichiro.f4@f.mail.nagoya-u.ac.jp

Place of BirthToyama, JapanEDUCATION:
Mar. 2005

B.S.

Department of Chemistry and Biotechnology, Faculty ofEngineering, The University of Tokyo, Tokyo, Japan

Mar. 2007

M.S. in Chemistry

Department of Chemistry and Biotechnology, School ofEngineering, The University of Tokyo, Tokyo, Japan

Mar. 2010

Ph.D. in ChemistryDepartment of Chemistry and Biotechnology, School ofEngineering, The University of Tokyo, Tokyo, Japan(Prof. Makoto Komiyama)

ACADEMIC APPOINTMENTS:
Apr. 2010 – Mar. 2011

Project Assistant Professor
Research Center for Advanced Science and Technology,
The University of Tokyo, Japan (Prof. Makoto Komiyama)

Apr. 2011 – Mar. 2012

Project Assistant Professor
Department of Chemistry and Biotechnology,
School of Engineering, The University of Tokyo, Japan

Jul. 2015 – Jun. 2020

Assistant Professor
Department of Chemistry,
Graduate School of Science, Nagoya University, Japan(Prof. Yoshihito Watanabe & Prof. Osami Shoji)

Jul. 2020 – Mar. 2021

Associate Professor / Lecturer
Department of Chemistry,Graduate School of Science, Nagoya University, Japan (Prof. Osami Shoji)

Apr. 2021 – present

Associate Professor
Department of Chemistry,
Graduate School of Science, Nagoya University, Japan (Prof. Osami Shoji)

PROFESSIONAL AND RESEARCH APPOINTMENTS:
Apr. 2007 – Mar. 2010

Research Fellow (DC1) of JSPS
the Japan Society for the Promotion of Science, Japan

Sep. 2008 – Nov. 2008

Visiting Researcher,
Department of Chemistry, University of Turku, Finland(Prof. Harri Lönnberg)

Apr. 2012 – Sep. 2012

Researcher
Life Science Center of TARA, University of Tsukuba, Japan(Prof. Makoto Komiyama)

Sep. 2012 – Sep. 2014

JSPS Postdoctoral Fellow for Research Abroad
the Japan Society for the Promotion of Science, Japan

Sep. 2012 –Jun. 2015

Postdoctoral Research Fellow II
Department of Pharmacology, University of Texas Southwestern Medical
Center, USA (Prof. David R. Corey)

Nov. 2015 – present

Visiting researcher
SPring-8 Center, RIKEN, Japan

AWARDS:
Feb. 2012

Inoue Research Award for Young Scientists,
Inoue Foundation for Science

Jun. 2012

Presentation Award for Young Scientists of 22nd symposium on Polymersand Biosciences,
Research Group on Polymers and Biosciences, The Society of Polymer
Science, JapanRESEARCH INTERESTS:
Nucleic Acid Chemistry:
Development of a novel artificial nucleic acid based on PNA and its application to genetic
engineering, Nucleic acid diagnostic tools and nucleic acid medicines utilizing PNA invasion
Biological Chemistry:
Peptide & protein engineering, Functionalization of hemoproteins by chemical modification

KEYWORDS:
PNA, peptide nucleic acid, invasion, DNA, RNA, peptide, protein, biopolymer, heme

SELECTED PUBLICATIONS:
1.

H. Nanaura, H. Kawamukai, A. Fujiwara, T. Uehara, Y. Aiba, M. Nakanishi, T. Shiota, M. Hibino, P.
Wiriyasermkul, S. Kikuchi, R. Nagata, M. Matsubayashi, Y. Shinkai, T. Niwa, T. Mannen, N. Morikawa, N.
Iguchi, T. Kiriyama, K. Morishima, R. Inoue, M. Sugiyama, T. Oda, N. Kodera, S. Toma-Fukai, M. Sato, H.
Taguchi, S. Nagamori, O. Shoji, K. Ishimori, H. Matsumura, K. Sugie, T. Saio*, T. Yoshizawa*, and E.
Mori*“C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers” Nat. Commun., 12, 5301
(2021)

2.

M. Hibino, Y. Aiba*, and O. Shoji*“Cationic guanine: positively charged nucleobase with improved DNA affinity inhibits self-duplexformation.” Chem. Commun., 56, 2546-2549 (2020)※Selected as an inside back cover3.

O. Shoji*, Y. Aiba, and Y. Watanabe* ““Hoodwinking Cytochrome P450BM3 into Hydroxylating Non-Native Substrates by Exploiting Its
Substrate Misrecognition.” Acc. Chem. Res., 52, 925-934 (2019)4.

S. Ariyasu, Y. Kodama, C. Kasai, Z. Q. Cong, J. K. Stanfield, Y. Aiba, Y. Watanabe, and O. Shoji*“Development of a High-Pressure Reactor Based on Liquid-Flow Pressurisation to Facilitate Enzymatic
Hydroxylation of Gaseous Alkanes.” ChemCatChem, 11, 4709-4714 (2019)※Selected as a cover picture and a cover profile5.

M. Hibino, Y. Aiba*, Y. Watanabe, and O. Shoji*“Peptide Nucleic Acid Conjugated with Ru-complex Stabilizing Double-Duplex Invasion Complex Even
under Physiological Conditions.” ChemBioChem, 19, 1601-1604 (2018)※Selected as a cover6.

K. Omura, Y. Aiba, H. Onoda, J. K. Stanfield, S. Ariyasu, H. Sugimoto, Y. Shiro, O. Shoji*, and Y.
Watanabe*“Reconstitution of full-length P450BM3 with an artificial metal complex by utilising the transpeptidaseSortase A.” Chem. Commun., 54, 7892-7895, (2018)※Selected as a cover7.

Y. Aiba, J. Hu, J. Liu, Q. Xiang, C. Martinez, and D. R. Corey*“Allele-Selective Inhibition of Expression of Huntingtin and Ataxin-3 by RNA Duplexes Containing
Unlocked Nucleic Acid Substitutions.” Biochemistry, 52, 9329-9338 (2013)※Highlighted on the journal’s home page, Highlighted in Chemical & Engineering News
8.

Y. Aiba, J. Sumaoka, and M. Komiyama*“Artificial DNA Cutters for DNA Manipulation and Genome Engineering.” Chem. Soc. Rev., 40, 56575668 (2011)※Selected as an inside cover

9.

M. Komiyama*, Y. Aiba, Y. Yamamoto, and J. Sumaoka“Artificial restriction DNA cutter for site-selective scission of double-stranded DNA with tunablescission-site and specificity.” Nat. Protoc. 3, 655–662 (2008)

10. M. Komiyama*, Y. Aiba, T. Ishizuka, and J. Sumaoka“Solid-phase synthesis of pseudo-complementary peptide nucleic acids.” Nat. Protoc. 3, 646–654(2008)