International Symposium on Global Neuroscience Cooperation
Date: Sunday, July 29th, 2018
Time: 9:00 a.m. – 12:00 a.m.
Location: Kobe Convention Center Kobe International Conference Center 3F Venue
7(504+505) http://www.neuroscience2018.jnss.org/en/satelite.html

Program
Opening Remarks: Kiyoto Kasai
9:00-9:25

Dr. Hideyuki Okano

Disease Modeling and Brain Mapping using genetically modified marmosets.
9:25-9:50

Dr. Patricia Michie

Cracking the Brain’s Code: Advocacy and international collaboration in Australia.
9:50-10:15

Dr. Gregory A. Light

The auditory steady state gamma band response is a sensitive biomarker of neuralsystem engagement following initial exposure to procognitive interventions forschizophrenia(Break)10:25-10:50

Dr. Kamil Ugurbil

Tentative title: High field MRI/Human connectome project
10:50-11:10

Dr. Takuya Hayashi

Towards primate connectome using non-invasive multimodal imaging
11:10-11:35

Dr. Afonso Silva

Tentative title: Marmoset MRI
11:35-11:55

Dr. Ichio Aoki

Nano- and functional-MRI contrast agents for neuroscience
Closing Remarks: Norihiro Sadato

Disease Modeling and Brain Mapping
using genetically modified marmosets

Cracking the Brain’s Code: Advocacy
and international collaboration inAustralia

Dr. Hideyuki Okano
Dr. Patricia T. Michie
Professor
Department of Physiology

Professor

Keio University School of

School of Psychology

Medicine

University of Newcastle

The common marmoset is a small New World

The Australian Brain Alliance (ABA) is a

primate that has been extensively used as

consortium of universities, research institutes,

biomedical research models. There is also an

professional societies and neuroscience

increasing interest in common marmoset in Brain

businesses formed in 2016 by the AustralianScience based on the its characteristic social

Academy of Science’s National Committee forbehavior, human like trait and as a model for

Brain and Mind to champion increased investment

exploration and discovery of knowledge-basedin Australian neuroscience, behavioral sciences

strategies for the eradication of major human brain

and psychology. The ABA has a collective vision

disorders due to the availability of genetic

to transform the Australian brain research sector

modification (GM) technology. We first developedand is calling for significant investment in an

GM technology of marmoset by lentiviral mediatedAustralian Brain Initiative to fund research to cracktransgenesis (Sasaki et al., Nature, 2009),

the brain’s code.

followed by generation of knock-out marmoset

The ABA also acts as a focal point for

using genome editing (Sato et al., Cell Stem Cell,country-level engagement with global brain2016). We generated transgenic marmoset

initiatives. With support of The Kavli Foundation

models of neurodegenerative diseases, including

the ABA hosted a workshop on global brain

Parkinson disease (PD) which overexpressed thescience collaboration in December 2017 thatmutant form of -synuclein suing lentiviral vector.

resulted in a Declaration from national brain

The PD model marmoset showed

programs and organisations from the US, EU,stage-dependent progression of the disease, such

Korea and Japan to establish an Internationalas sleeping disturbance followed by motor deficit.

Brain Initiative (IBI). This Declaration has

In addition, I will mention the Rett syndrome model

subsequently been endorsed by country programs

marmoset obtained by genome editing. Usingin China, Canada, Israel, and by IBRO and INCF.

these methods, additional GM marmoset lines will

The ABA is continuing to work closely with The

be generated and characterized for modeling

Kavli Foundation to support the IBI, and ishuman neurological and psychiatric disorders.

pursuing an innovative campaign strategy toAbnormalities in brain structure and function insecure support for a national brain program inthese marmoset models may accelerate discovery

Australia.

of disease biomarkers and mechanisms toward
translation (Okano et al., Neuron, 2016).

The Auditory Steady State Gamma Band
Response is a Sensitive Biomarker of
Neural System Engagement Following
Initial Exposure to Procognitive
Interventions for Schizophrenia

Towards primate connectome using
non-invasive multimodal imaging

Dr. Gregory A. LightTeam Leader

Dr. Takuya Hayashi

Brain Connectomics Imaging
Professor

Laboratory

Department of Psychiatry

RIKEN center for Biosystems

University of California,Dynamics Research

San Diego

While cognitive training and pharmacologic
strategies have shown promise for remediating
cognitive impairments in schizophrenia patients,
therapeutic response varies considerably acrossindividuals and is difficult to predict in the earlystages of treatment. Moreover, the developmentof effective treatments for cognitive impairments
has been hindered by a lack of direct measures ofbrain function that are sensitive to the neuralsystems engaged by procognitive interventions.
The Auditory Steady State Response (ASSR) to
gamma-frequency stimulation is increasingly used
as a functional biomarker of central auditory
system plasticity in translational neuroscience.
This presentation will show that the gamma bandauditory steady state response (ASSR) is
sensitive to initial exposure to somepharmacologic (e.g., memantine) andcomputerized cognitive training interventions. This
collection of findings supports the use of theASSR as a translational endpoint in procognitive
drug discovery and early phase clinical trial
designs. ASSR and related measures of EAIP
can contribute to future largescale biomarker
guided treatment strategies that target thecognitive impairments associated with psychosis.

The non-human primate (NHP) species is an
important neuroscientific model for understanding
neuroanatomy, function, connectivity of humanbrain. Although humans and NHPs are in thesame taxonomic group, their evolution werediverged long time ago – it has been 35 million
and 25 million years since humans wereseparated from marmosets and macaques
respectively. There have been attempts using
non-invasive imaging to address how human brain
is different from NHPs. However, a full picture ofcross-species homologies is yet to be establishedtounderstandthemacro-scalecorticalarchitectureandconnectome.
Recentadvancement of MRI such as high gradient
hardware, data acquisition and preprocessing
opened the way to address parcellation andconnectome in living human brain like done inhuman connectome project (HCP). We have been
recently developing the MRI techniques for NHP
connectome using a 3T MRI scanner. The RF
coils provided high SNR whole-brain coverage
and allowed parallel imaging with high speed
acquisitions of functional and diffusion MRI.
Combined with the NHPHCP preprocessing
pipelines, multimodal properties of structure andfunction in the gray matter were robustly mapped
onto cross-species standardized coordinates,‘grayordinates’. Applications of these techniquessuggest potential of the NHP connectome project
to find valid methods and models and tounderstand dynamics of primate connectome inevolution, sociality and plasticity.

Nano- and Functional-MRI Contrast
Agents for Neuroscience

Dr. Ichio Aoki
Group Leader
Group of Quantum-state
Controlled MRI
National Institutes forQuantum and Radiological
Science and Technology

In addition to the BOLD-based anddiffusion-based correlation analysis, some newgeneration contrast agents will contribute toneuroscience research in the near future, both inrodents and primates. Recently, the advent offunctional contrast agents and nanoparticle drugdelivery systems (nano-DDSs) has opened newpathways to understanding in vivo physiology andpathophysiology using MRI. For example, thecalcium phosphate nanomicelle-based
manganese contrast agent (Nat Nanotech
11(8):724-30, 2017) with BBB permeation
methods (Nat Commun 17;8(1):1001, 2017) may
provide depolarization-dependent contrast forassessing brain function low-invasively. I would
like to introduce our recent progress andprediction of the use of functional contrast agentsand nano-DDSs for neuroscience.

(Abstracts for Professors Silva and Ugurbil will be
posted soon.)