PRODUCTS & SERVICESHUMAN PROTEINS • ENZYMES • BBI BIOBANK • ANTIBODIESNANOPARTICLES • GOLD CONJUGATES • LATERAL FLOW TESTDEVELOPMENT & MANUFACTURE • CUSTOM DEVELOPMENT

02

CONTENTS
03

HUMAN PROTEINS

03 Acute Phase
03 Autoimmune
03 Bone Metabolism
03 Complement & Clotting Proteins
03 Hormones & Cytokines
03 Renal Markers
03 Immunoglobulins
03 Nutritional Markers
03 Tumour Markers
03 Inflammation Markers
03 Cardiac Markers
03 Plasma Proteins
03 Infectious Diseases– Viral– Parasitic/Protozal
04	Custom Development and Manufactureof Antigens

05

ENZYMES05 Diagnostic Enzymes (Clinical Chemistry)
05 Diagnostic Enzymes (Immunoassay)
05 Diagnostic Enzymes (Biosensor)
05 Diagnostic Enzymes (Urine Test Strips)
05 Diagnostic Enzymes (Molecular Biology)
06 Bulk Enzymes
06 Miscellaneous Applications
07	Custom Development and Manufactureof Enzymes

BBI BIOBANK08	

08 Autoimmune
08 Biochemistry
08 Diabetes
08 Cardiac
08 Hepatic
09 Hormones/Endocrine
09 Infectious Disease
09 Pregnancy
09 Renal
09 Tumour
09 Other
10 SCIPAC Clinical Specimen Panels

Part of BBI Group

11

ANTIBODIES

11 Monoclonal Antibodies– Bone Metabolism Markers– Cardiac Markers– Complement and Clotting Markers– Diabetes– Drugs of Abuse– Growth Factors
12 – Hormones– Immunoglobulins– Infectious Disease Markers
13 – Kidney Markers
14 – Pregnancy Markers– Sepsis Markers– Tag Markers– Thyroid Markers
15 – Tumour Markers
16	Mouse Monoclonals – Recommended
Matched Pairs for Immunoassays
17	Recombinant FabMonoclonal Antibodies– Autoimmune– Cardiac Markers– Diabetes– Inflammation Markers– Obesity– Pregnancy– Renal Function– Tumour Markers
18 Polyclonal Antibodies

19

NANOPARTICLES

19 – Gold Nanoparticles– Silver Nanoparticles– Platinum Nanoparticles

20

GOLD CONJUGATES

20 Anti-Biotin Conjugates
20 Disease State Conjugates
20 Fertility Conjugates
20 Anti-Human Conjugates
20 Control lines & Anti-species
20 Other Conjugates
21 Custom Conjugation
22 Lateral Flow Test Development
24 OEM Lateral Flow Test Manufacture
26 Our Products by Sector

HUMAN PROTEINSHUMAN PROTEINS
Disease Area

Product Name

Acute Phase

C-reactive protein (CRP)

Autoimmune

Bone Metabolism
Complement &Clotting Proteins(α) alpha - 1- acid glycoprotein

CA125(α) alpha - 1- antichymotrypsin (ACT)CA15-3(β) Beta-2-glycoprotein-1 (B2GP1)

CA19-9Thyroglobulin (Tg)

Carcinoembryonic antigen (CEA)

Thyroid peroxidase (TPO)
Vitamin D (derivatives andconjugates)
Complement C3c

CYFRA-21

Complement C4c
D-dimer (D-D)
Follicle stimulating hormone (FSH)

Neuron specific enolase (NSE)
Prostate-specific antigen (PSA)
PSA-ACT complex
Inflammation
Markers

C-reactive protein (CRP)

Cardiac Markers

Apolipoprotein A1 (Apo A1)
Creatine kinase MM (CK-MM)
Galectin 3 (Gal-3) (recombinant)High-density lipoprotein (HDL)
Low-density lipoprotein (LDL)
Myeloperoxidase (MPO)
Myoglobin (MYO)

Sex hormone-binding globulin (SHBG)

N-terminal prohormone brain
natriuretic peptide (NT-Pro BNP)

Cystatin C (CysC)

Troponin complex (cTn)

Lipocalin (NGAL) (recombinant)Troponin I

Retinol binding protein (RBP)

Troponin T

Tamm horsfall glycoprotein (THG)
Immunoglobulins

Plasma Proteins

Albuminα 1-microglobulin (α1M)

Butyryl cholinesterase (BCHE)

IgA

Ceruloplasmin

IgE

Thyroxine binding globulin (TBG)

IgG

Infectious Diseases

IgM

Viral

Kappa light chain
Lambda light chain
Nutritional Markers

Procalcitonin (PCT) (recombinant)Creatine kinase MB (CK-MB)

Growth hormone (hGH)
Human chorionic gonadotropin (hCG)
Parathyroid hormone (PTH)(recombinant)Placental lactogen (hPL)
Pregnancy-associated plasma
protein-A (PAPP-A)
Prolactin (recombinant) (PRL)

Renal Markers

Alpha fetoprotein (AFP)
Beta 2-microglobulin (β2M)

Complement C1q
Hormones &Cytokines

Tumour Markers

Haptoglobin

Albumin (ALB)
Ferritin
Prealbumin (Prealb)
Transferrin
Transferrin receptor (TfR)

HIV (recombinant)Dengue virus

Parasitic/Protozal

Malaria03

04

HUMAN PROTEINSCUSTOM DEVELOPMENT AND MANUFACTURE
OF ANTIGENS
Our custom antigen development service takes recombinant or native antigens from initial feasibility rightthrough to verification. If you can't find the antigens you are looking for, contact us today and we will do ourbest to provide a custom solution.

The Process

FEASIBILITY

OPTIMISATIONVERIFICATIONRECOMBINANT+ Screening of gene databases+ E coli & Pichia+ Cloning+ Transformation+ Small scale fermentation

RECOMBINANT+ Optimised growth conditions+ Formulation+ Downstream processing+ Purification+ Fermentation capacity of 30L
per batch

NATIVE & RECOMBINANT+ HPLC+ Western blot
+ Protein electrophoresis+ IEF Gels
+ Commercial autoanalysers+ Stability trials+ Validation

NATIVE+ Sourcing of raw materials ofhuman origin+ Small scale extraction andpurification

NATIVE+ Large scale extraction+ Downstream processing
purification

Discuss your requirements with our technical team on+44 (0) 2920 767 499 or email sales@bbisolutions.com

ENZYMESENZYMES
Industry

Application

Product Name

Diagnostic Enzymes

Clinical Chemistry

Cholesterol esterase
Cholesterol oxidase
Creatinase
Creatininase
Glucose-6 phosphate dehydrogenase
Glucose oxidase
Beta glucosidase
Glutamate dehydrogenase (GLDH)
Lactate dehydrogenase (LDH)
Malate dehydrogenase (MDH)
Mutarotase
Peroxidase
Phosphoenolpyruvate carboxylase (PEPC)
Sarcosine oxidase
UreaseUricaseXanthine oxidase

Immunoassay

Alkaline phosphatase
Intrinsic factor
Peroxidase

Biosensor

Glucose oxidase
FAD dependent glucose dehydrogenase
Cholesterol esterase
Cholesterol oxidase
Creatinase
Creatininase
Sarcosine oxidase
UreaseUricaseUrine Test Strips

Glucose oxidase
Peroxidase

Molecular Biology

Ribonuclease

05

06

ENZYMESENZYMES
Industry

Product Name

Bulk Enzymes

Chymotrypsin
Chymotrypsinogen
Cytochrome C
Deoxyribonuclease
Horseradish peroxidase
Hyaluronidase
Mucopolysaccharidase
Ribonuclease
TrypsinMiscellaneous Applications

AcylaseD-amino acid oxidase
Butyrylcholine esterase
Carbonic anhydrase
Catalase
Elastase
Hyaluronidase
Lipoxidase
Lysozyme
PepsinSuperoxide dismutase
Trypsin inhibitor

ENZYMESCUSTOM DEVELOPMENT
AND MANUFACTURE OF ENZYMESIf BBI Solutions off the shelf products do not meet your requirements, we offer a custom development andmanufacturing service for enzymes.

BBI’s Capabilities+	Specialists in sourcing and extraction of animal and plant products –We have extensive experience in sourcing raw materials worldwide+	Salt/solvent fractionation – Batch sizes of up to 5,000 litres+	
Chromatography – Ion exchange chromatography, affinity chromatography, size exclusion
chromatography, hydrophobic interaction chromatography+ Crystallisation – Highly effective protein purification using solvent and aqueous media+ Ultrafiltration – Volumes of 2,500 – 30,000 litres+ Freeze drying – Capacity of 48 – 420 litres per cycle+ Quality control – In-process analysis & monitoring, development of assay/test procedures+	
Product handling/sampling – We offer special packing according to customer specifications

The Process

FEASIBILITY

DEVELOPMENTVERIFICATIONVALIDATION+ Small scale
purification+ Process optimisation+ Routine protein analyses– Enzyme assays– Protein determinations– Analyticalchromatography– SDS PAGE
– Isoelectric focusing+E stablishedmanufacturing/
testing processes+ Critical processparameters gained+ Intermediate scale up+ Develop protocols toensure optimised yields

Discuss your requirements with our technical team on+44 (0) 2920 767 499 or email sales@bbisolutions.com+ Consistentconformance
to productspecification

07

08

BBI BIOBANKBBI BIOBANK – DISEASE STATE PLASMA / NORMAL PLASMA& SERUMS / PATIENT SAMPLES

Disease Area

Product Name

Bulk Units
No.

Patient
Grade
Sample No.

Matrix Available

Autoimmune

Anti-CCP negative

SH159

N/A

PlasmaAnti-dsDNA

SH237

N/A

Positive

PlasmaAnti-histones

SH291

N/A

Positive

PlasmaAnti-intrinsic factor

SH448

N/A

Positive

PlasmaAnti-nuclear Ab negative

SH139

N/A

Positive

PlasmaAnti-RNP/Anti-SS-A

SH293

N/A

Positive

PlasmaAnti-thyroglobulin (Tg) negative

SH246

N/A

Negative

Serum / Plasma

Anti-thyroglobulin (Tg) positive

SH245

SG311

Positive

Serum / Plasma

Anti-thyroid peroxidase (TPO) negative

SH174

N/A

Negative

Serum / Plasma

Anti-thyroid peroxidase (TPO) positive

SH244

SG310

Positive

Serum / Plasma

Anti-voltage gated potassium channel

SH128

N/A

Positive

Plasmac-ANCA (PR3 antibodies)

SH303

N/A

Positive

Plasma

CMV negative

SH602

N/A

Negative

PlasmaFree T3

N/A

SG312

Elevated

Serum

Free T4

N/A

Glomerular basement membrane (Anti GBM) SH336

Biochemistry

Diabetes

Cardiac

Hepatic

Positive

SG313

Elevated

Serum

N/A

Positive

Plasma

HAMA

SH327

N/A

Positive

Serum / Plasma

HSV1/2 negative

SH604

N/A

Negative

Plasmap-ANCA (MPO antibodies)

SH152

N/A

Positive

PlasmaRheumatoid factor (RF)

SH155

SG328

Positive

Serum / Plasma

Rubella negative

SH603

N/A

Negative

PlasmaSerum amyloid A

SH127

N/A

Positive

PlasmaSystematic lupus erythematosus (SLE)

N/A

SG292

Positive

Serum / Plasma

ToRCH negative

SH606

N/A

Negative

PlasmaToxoplasma negative
AlbuminAmmonia
Bicarbonate
Calcium
ChlorideCreatinine
Vitamin D
Diabetes type 1
Diabetes type 2
GlucoseInsulin
Cholesterol
C-reactive protein (CRP)
D-dimer
Myoglobin
NT proBNP
Triglyceride
Troponin I
Troponin T
Hepatically impaired
Bilirubin

SH601
N/A
N/A
N/A
N/A
N/A
N/A
SH370
N/A
N/A
N/A
N/A
N/A
SH100
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A

N/A
SG575
SG577
SG578
SG579
SG580
SG378
SG531
SG336
SG187
SG588
SG573
SG376
SG320
SG324
SG209
SG561
SG587
SG323
SG325-2
SG505
SG377

Negative
Level
Level
Positive
Level
Level
Elevated
Elevated
Positive
Positive
Elevated
Elevated
Elevated
Elevated
Elevated
Elevated
Elevated
Elevated
Elevated
Mixed Titre
Positive
Elevated

PlasmaSerum
PlasmaSerum
Serum / Plasma
Serum / Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum / Plasma
Serum
Serum
Serum
Serum / Plasma
Serum
Serum
Serum

All Biobank products subject to availability.

BBI BIOBANK

Disease Area Product Name
Hormones /Endocrine

Infectious
DiseasePregnancy

Cortisol
Growth hormone
Luteinising hormone (LH)
Oestradiol
Parathyroid hormone (PTH)
Progesterone
Sex hormone binding globulin (SHBG)
Testosterone
Thyroid stimulating hormone (TSH)
CMV IgG
CMV IgM
H. Pylori
Hepatitis A (HAV) IgM
Hepatitis C (HCV)
Hepatitis B (HBV) antibodies
HBsAg
HBc IgM
HIV 1
HIV 2
HIV window period
HIV/HBV co-infected
HTLV-1
Lyme IgG
Lyme IgM
Malaria
Measles IgG
Parvovirus B19
Rubella IgG
Rubella IgM (synthetic)
Syphilis
Toxoplasma IgG
Toxoplasma IgM
Beta-human chorionic gonadotropin (βhCG)
Human chorionic gonadotropin (hCG)
Pregnancy 1st trimester
Pregnancy 2nd trimester
Pregnancy 3rd trimester

Bulk Units
No.

Patient
Grade
Sample No.

Matrix Available

N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
SH242
SH272
SH270
SH265
SH259
SH257
SH256
SH258
SH315
SH316
SH313
SH314
SH329
SH307
SH309
SH334
SH481
SH331
SH250
SH252
SH266
SH240
SH275
N/A
N/A
SH285*
SH283*
SH284*

SG601
SG509
SG315
SG603
SG370
SG369
SG490
SG549
SG314
SG342
SG615
N/A
N/A
SH259
N/A
SH256
N/A
SH315
SG611
N/A
N/A
N/A
SG392
N/A
N/A
N/A
SG202
SG350
N/A
SH266
SG340
SG338
SG560
SG367
SG384
SG382
SG383

Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum / Plasma
Serum / Plasma
Serum / Plasma
PlasmaPlasmaSerum / Plasma
PlasmaPlasmaPlasmaSerum / Plasma
PlasmaPlasmaPlasmaSerum / Plasma
Serum / Plasma
Serum / Plasma
Serum / Plasma
Serum / Plasma
Serum / Plasma
Serum
PlasmaSerum / Plasma
Serum / Plasma
Serum / Plasma
Serum
Serum / Plasma
Serum / Plasma
Serum / Plasma

Positive
Elevated
Positive
Elevated
Elevated
Level
Elevated
Elevated
Elevated
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Positive
Elevated
Elevated
Positive
Positive
Positive

Renal

Renal failure

SH507

SG507

Positive

Serum / Plasma

Tumour/CancerMarkers

Alpha fetoprotein (AFP)
CA125
CA15-3
CA19-9Carcinoembryonic antigen (CEA)
Prostate specific antigen (PSA)

N/A
N/A
N/A
N/A
N/A
N/A

SG360
SG355
SG362
SG358
SG321
SG317

Elevated
Elevated
Elevated
Elevated
Elevated
Elevated

Serum / Plasma
Serum / Plasma
Serum
Serum
Serum / Plasma
Serum / Plasma

Other

Allergy – various types

SH166

SG508

Positive

Serum / Plasma

Total IgE

SH234

N/A

Elevated

Serum / Plasma

All Biobank products are subject to availability.
* Bulk units derived from pooled samples for ethically sourced bulk.

09

10

BBI BIOBANKBBI BIOBANK – SCIPAC CLINICAL SPECIMEN PANELS
Disease Area

Product Name

Bulk Units No.

Matrix Available

Infectious
DiseaseHIV-1 mixed viral load panel

SHK315-4V

Plasma

HBV mixed viral load panel

SHK256-4V

PlasmaHBV genotype panel

SHK256-4G

PlasmaHCV mixed viral load panel

SHK259-4V

Plasma

HCV genotype panel

SHK259-4G

PlasmaSyphilis mixed titre panel

SHK266-4M

PlasmaANTIBODIESANTIBODIES – MONOCLONAL ANTIBODIES
Disease Area

Product NameCat No.

Application

Capture / Detection

Bone Metabolism
Markers

Aggrecan "F(ab')2 fragments

BM447-M5H9

ELISA

CaptureAggrecan "F(ab')2 fragments

BM447-P7F2

ELISA

Detection

AggrecanBM447-M5H8

ELISA

CaptureCardiac Markers

Complement andClotting Markers

Diabetes

AggrecanBM447-P7F2

ELISA

Detection

Osteocalcin "F(ab')2 fragments

BM399-P5E6

ELISA

Detection

Osteocalcin

BM399-P5E5

ELISA

Detection

Osteocalcin

BM399-S6A3

ELISA

CaptureParathyroid hormone

BM361-E4H3

ELISA

Detection

Vitamin D 250H D2+D3

BM439-Z6B8

ELISA

CaptureACTH

BM445-S5B2

ELISA

CaptureFABP heart

BM442-D2C9

ELISA

Detection

FABP heart

BM442-D6D1

ELISA

CaptureMyoglobin

BM222-S1B5

LF

Detection

Myoglobin

BM222-T8D3

LF

CaptureMyoglobin

BM222-Z8G5

LF

Detection

NT-pro BNP

BM449-S2E1

LF

Detection

NT-pro BNP

BM449-P2F6

LF

CaptureRenin

BM438-K9C2

ELISA

CaptureRenin

BM438-S4D2

ELISA

Detection

Troponin I

BM322-K5F1

LF / ELISA / WB

CaptureTroponin I

BM322-M4E5

LF / ELISA / WB

Detection

Troponin I
D dimer clone 1D2

BM322-N4D1
BM243-1D2

LF / ELISA / WB
LF / ELISA / WB

CaptureELISA = Detection,
LF = Capture

D dimer clone 3B6BM243-3B6

LF / ELISA / WB

ELISA = Capture,
LF = Detection

Glycphorin A (red blood cell) clone
3A1

BM428-M4H4

HbA1c

BM300-F7C2

LF / ELISA / WB

Detection

HbA1c

BM300-H2B1

LF / ELISA / WB

Detection

HbA1c

BM300-H2E2

LF / ELISA / WB

Detection

HbA1c

BM300-P4D1

LF / ELISA / WB

Detection

HbA1c

BM300-S3C9

LF / ELISA / WB

Detection

Hemoglobin

BM302-F1B4

LF / ELISA / WB

CaptureHemoglobin

BM302-S6B9

LF / ELISA / WB

CaptureInsulin

BM364-Z8A2

ELISA

CaptureInsulin

BM364-T8F5

ELISA

Detection

Drugs of Abuse

THC Δ9

BM260-V1D6

ELISA / WB / LF

Competitive

Growth Factors

IGFBP3BM396-P6F9

ELISA

Capture

IGFBP3BM396-V3C7

ELISA

Detection

11

12

ANTIBODIESANTIBODIES – MONOCLONAL ANTIBODIES
Disease Area

Product NameCat No.

Application

Capture / Detection

Hormones

LH

BM200-K5C9

WB / ELISA

CaptureGrowth hormone

BM390-H2H5

ELISA

Detection

Growth hormone
Growth hormone "F(ab')2 fragments

BM390-G5F7
BM390-G5F8

ELISA
ELISA

CaptureCaptureProgesterone

BM320-F6A9

WB / ELISA

Competitive

Human IgA

BM400-K9G2

ELISA

Human IgE

BM395-G7D5

ELISA

Human IgG

BM376-P7B1

ELISA

Human IgM

BM377-H4A6

ELISA

C. difficile toxin A

BM346-E4B9

LF

CaptureC. difficile toxin A

BM346-F9C6

LF

Detection

C. difficile toxin B

BM347-N4A8

LF, ELISA, WB

CaptureC. difficile toxin B

BM347-T4G1

LF, ELISA, WB

Detection

Dengue NS1 subtypes 1 + 2

BM404-H3C7

LF

Dengue NS1 subtypes 1 + 2

BM404-K2G4

LF

Capture / Detection

Dengue NS1 subtype 1

BM409-V8F1

LF

Detection

Dengue NS1 subtype 1

BM409-Z2H9

LF

Dengue NS1 subtype 1

BM409-G3D1

LF

Detection

Dengue NS1 subtype 2

BM339-P3D8

LF

Capture / Detection

Dengue NS1 subtype 2

BM339-P6C6

LF

Capture / Detection

Dengue NS1 subtype 2

BM339-T3H2

LF

Capture / Detection

Dengue NS1 subtypes 2 + 3

BM405-K9A1

LF

Capture / Detection

Dengue NS1 subtype 3

BM406-F2E8

LF

Capture / Detection

Dengue NS1 subtype 3

BM406-G3E1

LF

Dengue NS1 subtypes 2 + 4

BM407-K3A2

LF

Detection

Dengue NS1 subtypes 2 + 4

BM407-N3F3

LF

Capture / Detection

Dengue NS1 subtype 4BM408-M2B3

LF

Detection

Dengue NS1 subtype 4BM408-F5F4

LF

Detection

Dengue NS1 subtype 4BM408-N9G5

LF

CaptureEbola Sudan

BM430-G9H1

LF

Ebola Zaire

BM431-M4B1

LF, WB

Ebola Zaire

BM431-O9C2

LF, WB

Ebola Zaire

BM431-V1D1

LF, WB

Ebola Zaire

BM431-Z2G2

LF, WB

Ebola (7 Zaire and 6 Sudan strains- 13 antibodies) panel

BM435-PANEL

LF*,WB*

Ebola Reston panel(5 antibodies)

BM433-PANEL

LF*

Ebola Sudan panel(6 antibodies)

BM430-PANEL

LF*

Ebola Zaire panel(7 antibodies)BM431-PANEL

LF*, WB*

Immunoglobulins

Infectious Disease
Markers* not all clones
suitable forapplication* not all clones
suitable forapplication* not all clones
suitable forapplication* not all clones
suitable forapplication

ANTIBODIES

Disease Area

Kidney Markers

Product NameCat No.

Application

Capture / Detection

HBsAg – TOTAL

BM310-P5H3

WB / ELISA

Capture / Detection

HBsAg – TOTAL

BM310-V4F9

ELISA

CaptureHBsAg – TOTAL

BM310-V8G2

WB / ELISA

CaptureHBsAg – TOTAL

BM310-Z2E8

ELISA

Detection

HIV2 (GP36)

BM375-D1C3

WB / ELISA

HIV P24

BM333-V4C3

LF

CaptureH. pylori

BM345-M5F6

LF

Capture / Detection

Leptospira

BM353-N8A9

LF

Listeria spp

BM401-K4H9

LF

Capture / Detection

Listeria spp

BM401-M7A5

LF

Detection

Listeria spp

BM401-T7B6

LF

CaptureMalaria HRP2 (Pf only)

BM340-F5D2

LF

Detection

Malaria HRP2 (Pf only)

BM340-S1F4

LF

CaptureMalaria HRP2 (Pf only)

BM340-U7D4

LF

CaptureMalaria HRP2 (Pf only)

BM340-V2B8

LF

Detection

Malaria HRP2 (Pf only)

BM340-Z2D5

LF

CaptureMalaria LDH

BM356-D2B4

LF

Detection

Malaria LDH (pan)BM355-P4A2

ELISA / LF

Detection

Malaria LDH (Pf and Pv only)

BM402-Z7C6

LF

CaptureMRSA (PBP2a)

BM306-M3D1

ELISA

CaptureMRSA (PBP2a)

BM306-O3G7

ELISA

Detection

MRSA (PBP2a)

BM306-S6G8

ELISA

CaptureNorovirus GI and GII

BM349-G1G1

LF

CaptureNorovirus GII

BM349-H1C3

LF

CaptureVanA (vancomycin resistantenterococci)
VanA (vancomycin resistantenterococci)
VanA (vancomycin resistantenterococci)

BM334-G3H9

ELISA

CaptureBM334-G8A5

ELISA

CaptureBM334-P2C1

ELISA

Detection

NGAL

BM344-P8H5

ELISA

Capture / Detection

NGAL

BM344-K8G8

ELISA

Capture / Detection

13

14

ANTIBODIESANTIBODIES – MONOCLONAL ANTIBODIES
Disease Area

Cat No.

Application

Capture / Detection

Pregnancy Markers AFP

BM315-F1C7

ELISA

Detection

AFP

BM315-H6H8

ELISA

CaptureAlpha hCG

BM319-M6H2

WB / ELISA

Capturebeta hCG

BM317-M5C9

WB / ELISA

Detection

beta hCG

BM317-P7E5

WB / ELISA

Detection

beta hCG

BM317-Z2A2

WB / ELISA

Detection

Fetal fibrinonectin

BM450-H9F7

ELISA

CaptureFetal fibrinonectin

BM450-V3B1

ELISA

Detection

Free beta HCG

BM317-T7H6

ELISA

CaptureFree beta HCG

BM317-S8D2

ELISA

Detection

Free beta HCG

BM317-N2B7

ELISA

Detection

FSH

BM202-V7D8

ELISA

CaptureFSH

BM202-Z1G4

ELISA

Detection

HCG

BM206-V6E9

ELISA

CapturePlacental lactogen

BM446-E6H6

ELISA

CapturePlacental lactogen

BM446-F4D6

ELISA

Detection

Prolactin

BM204-N5A1

ELISA

CaptureProlactin

BM204-T7G5

ELISA

Detection

Procalcitonin

BM448-M5C1

LF

Detection

Procalcitonin

BM448-H3D5

LF

CaptureProcalcitonin

BM448-D2F8

LF

CaptureProcalcitonin

BM448-M6F9

LF

CaptureProcalcitonin

BM448-T7H2

LF

Detection

Tag Markers

GST

BM426-H9E9

LF

Detection

Thyroid Markers

Tg

BM208-N1E7

TSH

BM216-T5C1

ELISA

CaptureTSH

BM216-V6D5

LF

Detection

TSH

BM216-S1A5

LF

CaptureTSH

BM216-T7F7

ELISA

CaptureTSH
TSH "F(ab')2 fragments

BM216-P8F4
BM216-P8F5

ELISA
ELISA

Detection
Detection

TSH

BM250-E6B7

TSH

BM216-P2E7

T3

BM440-P3H6

ELISA

CaptureT4

BM441-U6E2

ELISA

CaptureSepsis Markers

Product Name

CaptureDetection

ANTIBODIES

Disease Area

Product NameCat No.

Application

Capture / Detection

Tumour Markers

AFP

BM315-E2G9

WB / ELISA

CaptureCA125

BM234-S3A8

WB / ELISA

CaptureCA125

BM234-T5D5

WB / ELISA

Detection

CA15-3BM236-K2F4

WB / ELISA

CaptureCA15-3BM236-K6A5

WB / ELISA

Detection

CA15-3BM236-V2G9

WB / ELISA

CaptureCA19-9BM238-G6C8

WB / ELISA

CaptureCA19-9BM238-H7D1

WB / ELISA

Detection

CEA

BM220-E1E3

ELISA

Capture

CEA

BM220-D7C6

ELISA

Detection

CEA

BM220-E7E2

ELISA

Detection

CEA

BM220-F5H1

ELISA

Detection

15

16

ANTIBODIESANTIBODIES – MOUSE MONOCLONALSRECOMMENDED MATCHED PAIRS FOR IMMUNOASSAYS
Marker

Application

Paired Capture Ab

Paired Detection Ab

AFP

ELISA

BM315-F1C7

BM315-H6H8

Aggrecan

ELISA

BM447-M5H9

BM447-P7F2

C.difficile toxin B

LF

BM347-N4A8

BM347-T4G1

CA125

ELISA

BM234-S3A8

BM234-T5D5

CA15-3

ELISA

BM236-K2F4 or BM236-V2G9

BM236-K6A5

CA19-9ELISA

BM238-G6C8

BM238-H7D1

CEA

ELISA

BM220-E1E3

BM220-D7C6 or BM220-E7E2
or BM220-F5H1

D-dimer

LF

BM243-1D2

BM243-3B6

D-dimer

ELISA

BM243-3B6

BM243-1D2

Dengue NS1 subtype 1

LF

BM409-K2G4

BM409-G3D1

Dengue NS1 subtype 1

LF

BM409-K2G4

BM409-V8F1

Dengue NS1 subtype 1

LF

BM409-P3B4

BM409-G3D1

Dengue NS1 subtype 2

LF

BM339-T3H2

BM339-P3D8

Dengue NS1 subtype 2

LF

BM339-T3H2

BM339-P6C6

Dengue NS1 subtype 3

LF

BM406-F2E8

BM405-K9A1

Dengue NS1 subtype 3

LF

BM405-K9A1

BM406-F2E8

Dengue NS1 subtype 4

LF

BM408-N9G5

BM407-K3A2

Dengue NS1 subtype 4

LF

BM408-N9G5

BM408-G8E7

FABP Heart

ELISA

BM442-D6D1

BM442-D2C9

Fetal FibrinonectinFree beta HCG Monoclonal
Antibody

ELISA

BM450-H9F7

BM450-V3B1

ELISA

BM317-T7H6

BM317-S8D2 / BM317-N2B7

FSH

ELISA

BM202-V7D8

BM202-Z1G4

Giardia

LF

BM423-V5C5

BM423-V5C5

Growth Hormone

ELISA

BM390-G5F8

BM390-H2H5

HBsAg Ad/Ay

LF, ELISA

BM310-V4F9

BM310-Z2E8

HCG beta

ELISA

BM317-M5C9

BM317-P7E5 or BM317-Z2A2

HCG total

ELISA

BM319-M6H2

BM317-M5C9

HbA1c

LF, ELISA

BM302-F1B4 or BM302-S6B9BM300-F7C2

IGFBP3

ELISA

BM396-P6F9

BM396-V3C7

Insulin

ELISA

BM364-Z8A2

BM364-T8F5

Listeria

LF

BM401-K4H9

BM401-M7A5 or BM401-T7B6

Malaria (Pf and Pv)

LF, ELISA

BM402-Z7C6

BM355-P4A2

Malaria (Pf)

LF, ELISA

BM356-S1C8

BM355-P4A2

Malaria HRP

LF

BM340-F5D2

BM340-F5D2

Malaria HRP

LF

BM340-F5D2

BM340-Z2D5

Malaria pLDH

LF

BM355-P4A2

BM355-P4A2

Myoglobin

LF

BM222-T8D3

BM222-Z8G5NT-pro BNP

LF

BM449-P2F6

BM449-S2E1

Osteocalcin

ELISA

BM399-S6A3

BM399-P5E6

PBP2A

ELISA

BM306-M3D1

BM306-O3G7

Placental Lactogen

ELISA

BM446-E6H6

BM446-F4D6

ANTIBODIES

Marker

Application

Paired Capture Ab

Paired Detection Ab

Procalcitonin

LF

BM448-H3D5

BM448-M5C1

Prolactin

ELISA

BM204-N5A1

BM204-T7G5

Renin

ELISA

BM438-K9C2

BM438-S4D2

Troponin I

ELISA

BM322-N4D1 or BM322-K5F1

BM322-M4E5

TSH

ELISA

BM216-T5C1 / BM216-T7F7

BM216-P8F5

TSH

LF

BM216-S1A5

BM216-V6D5

VanA

ELISA

BM334-G8A5 or BM334-G3H9

BM334-P2C1

ANTIBODIES – RECOMBINANT FAB MONOCLONAL ANTIBODIES
Disease Area Biomarker

Application

Detection Range*

CaptureAntibody

Detection
Antibody

2 – 1200 ng/mL

BR240-N5G6

BR240-D8B4

Autoimmune

MPO

ELISA / Luminex

Cardiac
MarkerAdiponectin

Competitive ELISA / 230 – 59118 ng/mL
Luminex

BR101-H2B4(Competitive)

Diabetes

Adiponectin

ELISA

0.1 – 525 ng/mL

BR101-P7E2

BR101-M3H8

CKBB

ELISA

0.15 – 33 ng/mL

BR112-V6F6

BR112-Z1C4

E-selectin

ELISA

0.05 – 235 ng/mL

BR117-K2E7

BR117-H5B6

Neutrophil elastase

ELISA

0.008 – 33 ng/mL

BR127-H2A4

BR127-G7C2ST2ELISA / Luminex

1.39 – 97 ng/mL

BR139-S7B7

BR139-V8D4ST2

ELISA / Luminex

0.08 – 31 ng/mL

BR139-T3G5

BR139-V8D4

Proinsulin C-peptide

ELISA / Luminex

0.09 – 38 ng/mL

BR143-G5D3

BR143-K7C9ELISA / Luminex

151 – 231000 ng/mL

BR228-D4A3(Competitive)

Inflammation CRP
Markers
FABP intestine

ELISA

0.65 – 100 ng/mL

BR115-F7G7

BR115-G6B9

LeptinELISA

0.17 – 135 ng/mL

BR123-F8F4BR123-F4H5

LeptinELISA / Luminex

3.9 – 691 ng/mL

BR123-M4D6

BR123-P4G2

Pregnancy

Free PAPP AELISA / Luminex

0.3 - 299 ng/mL

BR129-M5E3

BR129-F2H4

Renal
Function

Cystatin C

ELISA

165 – 9073 ng/mL

BR175-G8D9(Competitive)

Cystatin C

ELISA

165 – 9073 ng/mL

BR175-H4C8(Competitive)

FABP liver

ELISA

0.03 – 90 ng/mL

BR106-G5A2

BR106-P9F5

Obesity

TumourMarkers

Angiopoietin 2

ELISA

0.001 – 97 ng/mL

BR103-P4E8

BR103-V5F2

Big endothelin 1

ELISA / Luminex

0.001 – 1.8 ng/mL

BR104-D6A4

BR104-H1A4

Calcitonin

ELISA

0.006 – 2 ng/mL

BR388-G6B1

BR388-D5C4

Cathepsin D

ELISA

0.03 – 150 ng/mL

BR107-F5G2

BR107-K6D3

Eotaxin

ELISA

0.007 – 2 ng/mL

BR108-M7H3

BR108-K2D9

HSP60

ELISA

0.1 – 1200 ng/mL

BR100-G2A7

BR100-H4C2

MMP7

ELISA

0.1 – 293 ng/mL

BR124-S4E3

BR124-T6G8

S100 beta

ELISA

0.04 – 5.6 ng/mL

BR332-G4B9

BR332-F5H7

17

18

ANTIBODIESANTIBODIES – POLYCLONAL ANTIBODIES
Disease Area

Biomarker

Cat No.

Species Raised in

Anemia Markers

Ferritin

BP230-3

RabbitHaptoglobin

BP228-3

Goat

Cardiac Markers

CKMM

BP295-3

Goat

Complement & Clotting

C4

BP226-3

Goat

Diabetes

Haemoglobin

BP331-3

Goat

Immunoglobulins

Chicken IgYBP440-3

Goat

Goat IgG

BP441-3

DonkeyKappa

BP222-3

Chicken

Mouse IgG

BP438-3

Goat

Inflammation Markers

Rabbit IgG

BP439-3

Goat

CRP

BP200-3A

Goat

Pulmonary Markers

A1AT

BP212-3

Goat

Renal Markers

A2M

BP214-3

ChickenAlbumin

BP208-3

Goat

Tumour Markers

Cystatin C

BP234-3

Goat

AFP

BP210-3

Goat

B2M

BP216-3

Chicken

Ceruloplasmin

BP218-3

Chicken*D etection Range is assay dependent. These antibodies have been optimised for sensitivity levels required for the detection of a specificcondition. It is likely that the detection range can be extended beyond the figure published here.

NANOPARTICLESNANOPARTICLES
Particle TypeSize

Cat No.

Available Sizes

Gold Nanoparticles

2nm

EM.GC2

20ml, 100ml, 500ml, 1l

5nm

EM.GC520ml, 100ml, 500ml, 1l

10nm

EM.GC10

20ml, 100ml, 500ml, 1l

15nm

EM.GC15

20ml, 100ml, 500ml, 1l

20nm

EM.GC20

20ml, 100ml, 500ml, 1l

30nm

EM.GC30

20ml, 100ml, 500ml, 1l

40nm

EM.GC40

20ml, 100ml, 500ml, 1l

50nm

EM.GC50

20ml, 100ml, 500ml, 1l

60nm

EM.GC60

20ml, 100ml, 500ml, 1l

80nm

EM.GC80

20ml, 100ml, 500ml, 1l

100nm

EM.GC100

20ml, 100ml, 500ml, 1l

150nm

EM.GC150

20ml, 100ml, 500ml, 1l

200nm

EM.GC200

20ml, 100ml, 500ml, 1l

250nm

EM.GC250

20ml, 100ml, 500ml, 1l

20nm, 40nm, 60nm, 80nm

GCIKITDIAG Plus

4x100ml

20nm, 40nm, 60nm, 80nm

GCIKITDIAG

4x20ml5nm, 10nm, 20nm, 40nm

GCIKITLIFE

4x20ml20nm

EM.SC20

20ml, 100ml, 500ml, 1l

40nm

EM.SC40

20ml, 100ml, 500ml, 1l

60nm

EM.SC60

20ml, 100ml, 500ml, 1l

80nm

EM.SC80

20ml, 100ml, 500ml, 1l

20nm

EM.PT20

20ml, 100ml

Silver Nanoparticles

Platinum Nanoparticles

High OD nanoparticles available in all particle sizes 2-250nm up to OD 100.

*OD 100 limited to 1ml batch sizes.

19

20

GOLD CONJUGATESGOLD CONJUGATESConjugate Type

Product NameCat No.**Anti-Biotin Conjugates

Streptavidin

BA.STP20 / BA.STP40

Monoclonal anti biotin 40nm

BA.MAB40

Goat anti biotin

BA.GAB20 / BA.GAB40

Disease State ConjugatesAnti-HbsAg*

BA.HbsAg40

Fertility ConjugatesAnti-beta hCG*

BA.HCG40

Anti-LH*

TR.LHQ0

Anti-Human Conjugates

Goat anti human IgG

BA.GAHL40

Protein A

BA.PAG20 / BA.PAG40

Goat anti human IgG Fc fragment

BA.GAH40

Goat anti human IgM Fc5μ fragment

BA.GAHM40

Control lines & Anti-species

Other Conjugates

Goat anti human IgA

BA.GAHA40

Chicken IgY*

CONT.CHICK

Goat anti-rabbit IgG

BA.GAR40

Goat IgG

BA.GG40

Mouse IgG

BA.MG40Goat anti-mouse

BA.GAM40

BSA conjugate

BA.BSA40

Goat anti-mouse IgM*

BA.GAMM40

The gold and conjugation processes at BBI
are unrivalled – we found that BBI was thebest that we could work with.
CEO James Lousararian, Verax Biomedical* Matched pair available on request.
** 20 denotes 20nm particles used in conjugate, 40 denotes 40nm particles used in conjugate.

GOLD CONJUGATESCUSTOM CONJUGATIONOur custom conjugation service provides high quality conjugates, optimised to meet your unique quality control
requirements. Our experienced scientists work directly with you to provide sensitive, specific, and reproducible
conjugates.

The Service+	
Develop high quality conjugates using antibodies, antigens, oligos or aptamers provided by you orsourced by us+ Conjugate to numerous nanoparticles including BBI Solutions’ world renowned gold+	
Optimise the sensitivity of your conjugate to meet your pre-agreed requirements and stability
Batch production up to 24 litres at OD10, or alternatively we can provide a custom OD preparation+	

We conjugate to numerous nanoparticles including:+ Gold nanoparticles+ Silver nanoparticles+ Platinum nanoparticles+ Latex nanoparticles+ Magnetic nanoparticles

Designed to meet your individual needs
Specificity, sensitivity and reproducibility should define thespecification and fulfil your absolute minimum expectationsof the conjugate.
Our scientists work in partnership with customers to bring all
the vital ingredients together and provide sensitive, stable,
reproducible conjugates time after time.

Thiol-inked
biomoleculesOnce you are happy with your conjugate, we can put acommercial supply plan in place to ensure security of supply.

Discuss your requirements with our technical team on+44 (0) 2920 767 499 or email sales@bbisolutions.com

Peptides/Affimers
Oligonucleotides/
Aptamers

21

22

CONTRACT SERVICESLATERAL FLOW TEST DEVELOPMENT

Are you looking to outsource your lateral flow test development?
At BBI Solutions we understand that getting a fast, accurate result is critical.
Whether you are looking to improve an existing assay or develop a new assay, we offer an end to end,
customised solution that will allow you to deliver a robust, reliable result to the global market place.

Our capabilities
Our capabilities allow us to take assay development from initial antibody screening through to final
manufacture and beyond. We have over 25 years' experience developing more than 250 qualitative,
semi quantitative and quantitative assays.

Companion

Diagram to showcase the markets, sample matrices and detection technologies we have worked with.

CONTRACT SERVICES

Our flexible turnkey approach
Our turnkey approach means you’re not locked in. A dedicated team of scientists work on your product alone,
and at the end of the development we hand over the design history file so that you ‘own’ your test.
Depending on the complexity of the assay, a typical development programme for a standard IVD will work as follows:

Product
verification andprocess andproduct
validation

Preparation
for Launch

Regulatory
approvalobtained

Post Market
Activities

Design Review

Materials,
formulation andprocesses
finalised, processrobustness tested
and pilot batches
generated

Confirmationthat design
outputs meet
design inputs

Design Review

Design Review

Feasibility ofvariousformulations
and processes
to arrive at
feasibility
prototype

Design Verification& Validation

Design Review

Optimisation &Characterisation

Feasibility

Implementationof post market
vigilance andsurveillance

Next generation assay development to enhance the performance of your test
BBI has an unparalleled technical skill set and access to the latest performance enhancing platforms andtechnologies to help customers make the best test possible.

Ask us about our:+ Sensitivity enhancement technology – offering you the opportunity to potentially increase the sensitivityof your assay – without increasing its complexity+ Award winning integrated platforms – simplifying the process for end users whilst reducing the risk ofuser error and cross contamination+ Novarum DX mobile reader solution – allowing quantitative analysis in real time using smartphone technology

23

24

CONTRACT SERVICES

OEM LATERAL FLOW TEST MANUFACTURE

Robust and flexible manufacturing options
You may be a new start-up company looking for someone to manufacture your assay, or a fast growing company
under pressure to meet increasing demand. Our manufacturing service will deliver the results you need to fulfil
your customer’s expectations:

Key Benefits+ Flexible options – catering for increased demand and technically challenging manufacture.
+ Technical transfer to manufacturing – BBI has extensive experience and expertise in successfullytransferring IVD products to manufacturing.
+ Competitive product pricing – using our automation capabilities to manufacture on a large scale will
drive production costs down without compromising quality.
+ Reliable supply – we have more than 60 assays in routine manufacture across our facilities located in the
UK (Cardiff, Wales; Dundee, Scotland) and the USA (Madison, Wisconsin).
+ Quality assurance guaranteed – all of our sites are ISO 13485 and ISO 9001 accredited and our Dundeesite is an FDA registered facility.

CONTRACT SERVICES

BBI’s Manufacturing
Capabilities
THE FACTS+ 30,000 sq feet for manufacturing+ Capacity of up to 15 million assays+ 5K to 100K+ device batch sizes+ Facilities located in the UK (Cardiffand Dundee) and the USA (Madison)+ ISO 13485 and ISO 9001 certified
QMS systems across all sites

25

26

OUR PRODUCTS BY SECTOR

SECTOR
Reagent Distributors
Research / Academic Institutions
ELISA Assay Manufacturers
Biochemistry Autoanalyser
Manufacturers
Immunoassay Autoanalyser
Manufacturers
Instrument Manufacturers
Lateral Flow Device Manufacturers
Point of Care Device Manufacturers

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Diagnostic Testing Laboratories
Clinical Chemistry Control
Manufacturers
Quality Control schemes

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Cell Culture Media Manufacturers
Contract Research / Manunfacturingorganisations

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a
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Cosmetic Manufacturers
Military / Defence Agencyrm

Raw Materials / Reagents

Molecular Biology Assay
Manufacturers
Third party Assay Development
CompanyNo

An(Mo tibod
noc ies
lon
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An
t
(po ibodi
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lk D
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Urinalysis strip manufacturersDe
ple
and ted S
Pla erumsma

PRODUCTS• = Relevant product(•) = Potentially relevant for some customers

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Raw Materials / Reagents

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27

info@bbisolutions.com
Int: +44 (0) 2920 767 499
USA: 1-800-423-8199
China: +852 2159 9666
www.bbisolutions.com

JULY 16/V5

Get in touch to arrange a sample or find out more about
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