Product Safety Summary for Glycerine carbonate
SUBSTANCE NAME
Glycerine carbonate
Glycerol-1,2-carbonate
4-hydroxymethyl-1,3-dioxolan-2-one
1,3-Dioxolan-2-one, 4-(hydroxymethyl)4-(hydroxymethyl)-1,3-dioxolan-2-one

GENERAL STATEMENT
Glycerine carbonate is a cyclic carbonate with two reactive functional groups. Glycerine carbonate is a colorless
liquid with a mild odour. It is an organic compound with a wide range of uses and applications. Its main use isas raw material for the production of materials made of polyester or polyurethane. It is a non-dangerous
substance

CHEMICAL IDENTITYEC Name:
EC-No. :CAS-No. :Molecular formula:

4-hydroxymethyl-1,3-dioxolan-2-one
213-235-0
931-40-8
C4H6O4Structural formula:

USES AND APPLICATIONS
Glycerine carbonate is a colorless liquid with a mild odour used mainly to as raw material for the production ofmaterials made of polyester or polyurethane. Glycerine carbonate can also be found in cosmetics such perfumes
and fragrances.

PHYSICAL CHEMICAL PROPERTIES
Glycerine carbonate is a colorless liquid with a mild odour.
Melting point/range:-60°C at 1013 hPa
Boiling point/boiling range:
239°C at 102.1 kPa
Decomposition temperature:
Not determinedFlashpoint:
149.5°C at 101.3 kPa
Flammability (solid, gaseous): Non flammable
Ignition temperature:
404°C at 1013 hPa

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Product Safety Summary for Glycerine carbonate
Explosive properties:
Molecular weight:

Product does not present an explosion hazard.
118.088 g/mollog Pow:
Vapor pressure:
Relative density:
Solubility in/Miscibility
with water:
Dynamic Viscosity:-1.39 at 25ºC
0.93 Pa at 25°C
1.41 at 20°C
1000 g/L
82.706 cSt at 20°C

HEALTH EFFECTS
Glycerine carbonate is not classified as a hazardous substance. There are no experimental (animal or human)data on the toxicokinetic behavior of it (except an in vitro dermal absorption test of Glycerine carbonate) but,
based on its physical-chemical parameters and available data, Glycerine carbonate absorption factors have been
estimated to be 50% and 100% after oral and inhalation exposure respectively. It is not classified as skin or eye
irritation, neither sensitization substance nor CMR or STOT.

EFFECT ASSESSMENT
Acute Toxicity(oral/dermal/inhalation)
Irritation/Corrosivity(skin/eye/respiratory tract)
Sensitization(skin/respiratory tract)
Repeated Dose Exposure
Mutagenicity

RESULTNo adverse effect observed for acute toxicity for any of the routes(oral, dermal or inhalation)
Skin irritation / corrosion: No adverse effect observed (not irritating)
Eye irritation / corrosion: No adverse effect observed (not irritating)Respiratory irritation / corrosion: No study available
Study does not allow to conclude on the skin sensitisation potentialof the substance. No adverse effect observed (not sensitising).
There are no available study for respiratory sensitisation.
Glycerine carbonate is not classified as STOT RE.

Carcinogenicity

No adverse effect observed (negative). Glycerine carbonate is notclassified as a mutagenic agent
No carcinogenicity data is available.

Reproductive Toxicity

Not classified as reproductive toxicant.

ENVIRONMENTAL EFFECTS
Three acute fish studies were available. Two studies were performed with Glycerine carbonate and one study wasperformed using the read-across substance Glycerol. No mortality were seen at the highest concentrations tested.
Based on these results, Glycerine carbonate can be classified as not harmful for fish, so as a conclusion, Glycerinecarbonate is not classified for environment.
Bioaccumulation of Glycerine carbonate is not expected because of very low Kow.
EFFECT ASSESSMENT
Aquatic Toxicity

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RESULT
Based on available acute toxicity data, Glycerine carbonate should
not be classified for the aquatic environment.

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Product Safety Summary for Glycerine carbonate

FATE AND BEHAVIOR
Biodegradation

Bioaccumulation potential

PBT/vPvB conclusion

RESULT
Glycerine carbonate is readily biodegradable in water andsediment.
Biodegradability in soil and sediment is not relevant (does nothave to be performed) due to the substance is readily
biodegradable.
Very low bioaccumulation potential
Glycerine carbonate is neither PBT nor vPvB based on
biodegradation and bioaccumulation results and no hazard toaquatic species.

EXPOSURE
Human Health
Exposure to Glycerine carbonate can occur to workers in industrial facilities where it is produced, stored,handled, formulated or processed. Professional users or consumers may come into contact with Glycerinecarbonate through commonly used formulated products, such as solvents, cosmetics, perfumes, fragrances.
Base on the uses, the most likely routes of exposure of Glycerine carbonate are skin contact and inhalation.
However, the health effects of Glycerine carbonate are such that it does not pose a risk to any kind of user, so
as the substance is not classified for human health or environmental hazards, no hazard was identified.
Environment
Glycerine carbonate may be released to the environment in air and water from manufacturing and industrial
use facilities and also from fragrances and cosmetics from the users. However, all identified uses of thesubstance have been assessed as safe for the environment.
The substance has been classified as readily biodegradable, with a very low potential of bioaccumulation andnot PBT/vPvB.
Consequently, all identified uses of the substance are assessed as safe for human health and the environment.

RISK MANAGEMENT RECOMMENDATIONS
Glycerine carbonate is not classified for human health or environmental hazards, so the substance is not ahazardous substance. However, it is a good practice to train personnel that handle the substance and toprotect workers who may be exposed to Glycerine carbonate by taking the usual precautionary measures toprotect against chemical exposure. Therefore, protective clothing, gloves and safety glasses should be worn
when handling Glycerine carbonate. Unless high concentrations are present, respiratory protection is not
required, provided ventilation is good.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
Glycerine carbonate is listed in the following Chemical Inventories: EINECS, IECSC, Canada DSL, KECI, ECNS,TSCA,December 14th, 2017

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Product Safety Summary for Glycerine carbonate
REGULATORY INFORMATION/CLASSIFICATION AND LABELINGThe substance is not classified according to the CLP Regulation. (REGULATION (EC) No 1272/2008)

CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company:
Department:
Address:
Town/Country:
Postal code:
E-mail:UBE Corporation Europe, S.A.U
R&D Product Liability
Poligono Industrial El Serrallo, s/nGrao de Castellon (Castellon), Spain
12100
sds.ube.eu@ube.es

Additional information can be found at:
http://www.ube.es
http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/

GLOSSARY
Acute toxicity
Bioaccumulation

Carcinogenicity
Chronic toxicity
CAS
Canadian DSL
EINECS
ENCS
KECI
IECSC
TSCA
GHS
HPV
Mutagenicity
PBT

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Harmful effect resulting from a single or shortterm exposure to a substance.
Progressive accumulation in living organisms ofa chemical substance present in theenvironment.
Substance effects causing cancer.
Harmful effect after repeated exposures or longterm exposure to a substance.
Chemical Abstracts Service (division of theAmerican Chemical Society).
Domestic Substances List of Canada.
European Inventory of Existing Commercial
Chemical Substances
Existing Notified Chemical Substances (Japan).
Korean Existing Chemical Inventory.
Inventory of Existing Chemical Substances
Produced or Imported in China.
Toxic Substance Control Act (USA).
Globally Harmonized System of Classificationand Labeling of Chemicals
High Production Volume Chemicals.
Substance effect that cause mutation on genes.
Persistent, bioaccumulative, toxic chemical.

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Product Safety Summary for Glycerine carbonate
Persistence

Refers to the length of time a compound stays inthe environment, once introduced.

Risk Management Measures

Engineering controls, conditions and protective
equipment needed to be implemented to ensurethat the risks to human health and theenvironment are adequately controlled.
European Commission Regulation concerning
the Registration, Evaluation, Authorization andRestriction of Chemicals.
European Commission Regulation onClassification, Labeling and Packaging ofSubstances and Mixtures.
Including teratogenicity, embryotoxicity andharmful effects on fertility.
Allergenic.
Topsoil, sand and minerals washed from land
into water forming in the end a layer at thebottom of rivers and sea.
A measure of a substance’s property toevaporate.
Very persistent, very bio-accumulative.

REACH (EC) No. 1907/2006

REGULATION (EC) No 1272/2008

Reprotoxicity
Sensitizing
Sediment

Vapor pressurevPvB

DATE OF ISSUE
December 2017

REVISION
Version 2.0

DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information is provided
in utmost good faith and has been based on the best information currently available, is to be relied uponat the user’s own risk. No representations or warranties are made with regards to its completeness oraccuracy and no liability will be accepted by UBE Corporation Europe, S.A.U for damages of any naturewhatsoever resulting from the use of or reliance on the information.

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