DAY 1: March 21, 2015 Saturday
Opening Remarks

13：00～13：05
Organizer: Kinji Ohno, Nagoya University

Special Lecture 1

13:05～13：45
Chair: Masatoshi Ichihara, Chubu University

Efforts to realize hydrogen gas medicine
Motoaki Sano, Keio University

Scientific Session 1

13：45～14：21
Chair: Mami Noda, Kyushu University

1.

Molecular hydrogen’s effects on glycometabolism
Mikako Ito1, Tomoyoshi Soga2, Kinji Ohno1
1

Neurogenetics, Nagoya Univ. Grad. Sch. of Med., 2Institute for Advanced Biosciences (IAB),

Keio University
2.

Effects of hydrogen gas on oxygen consumption rate of mitochondria
Kenichi Kokubo1, 2, Jumpei Shimoda1, Yoshitaka Kurihara2, Kozue Kobayashi1, 2,Hirosuke Kobayashi1, 2
1

3.

Kitasato Univ. Sch. of Allied Health Sci., 2Kitasato Univ. Grad. Sch. of Med. Sci.

Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses
signaling pathways in rodents
Sayaka Sobue1, Chisato Inoue1, Mikako Ito2, Kinji Ohno2, Masafumi Ito3,
Masatoshi Ichihara 1
1

Chubu University, 2Nagoya Univ. Grad. Sch. of Med., 3Tokyo Metropolitan Inst.

Gerontology

Coffee Break

14：21～14：40

4Keynote Lecture

14：40～15：20
Chair: Hirosuke Kobayashi, Kitasato University

Hydrogen Medicine Update 2014-2015
Shigeo Ohta, Nippon Medical School

Scientific Session 2

15：20～16：08

Chair: Akito Shimouchi, National Cerebral and Cardiovascular Center
4.

The number of hydrogen-producing bacteria in Parkinson’s disease
Satoru Hasegawa1,2, Hirokazu Tsuji3, Sae Goto1, Takashi Asahara3, Koji Nomoto3,
Akihide Shibata2, Yoshiro Fujisawa1, Akira Okamoto4, Kinji Ohno2, Masaaki Hirayama1
1

Department of Pathophysiological Laboratory Sciences 2Division of Neurogenetics, Nagoya

Univ. Grad. Sch. of Med., 3Yakult Central Institute, 4Department of School Health Sciences,
Aichi Univ. of Education
5.

Hydrogen water inhibits gefitinib-induced lung injury by anti-inflammatory effects
Masumi Iketani1, Kozue Tonaki１,4, Tetsuya Suzuki1,2, Jumi Ohshiro1,2,Yasuhiro Terasaki3, Mayumi Takahashi1, Hideo Kawaguchi2, Seisuke Hattori4,Ikuroh Ohsawa1
1

Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, 2Faculty of Life

Sciences, Toyo University, 3Department of Analytic Human Pathology, Nippon MedicalSchool, 4Kitasato University School of Pharmacy
6.

Hydrogen supplementation of preservation solution improves viability of osteochondral
graftsTakuya Yamada1, Kentaro Uchida2, Kenji Onuma2, Masanobu Ujihira1,Kiyoshi Mabuchi1, Gen Inoue2, Bunpei Sato3, Ryosuke Kurokawa3, Masashi Takaso2
1

Grad. Sch. of Medical Sciences, Kitasato Univ. 2Department of Orthopedic Surgery, Kitasato

Univ. Sch. of Medicine, 3MiZ Co., Ltd
7.

Effects of antioxidants on emanation of hydroxyl radicals from human skin
Naoya Jinno1,2, Dock-Chil Che3, Akito Shimouchi1
1

Department of Cardiac Physiology, National Cerebral and Cardiovascular Research Center,2

Research Fellow of Japan Society for the Promotion of Science, 3Department of Chemistry,Graduate School of Science, Osaka University

5Coffee Break

16：08～16:25

Leading Edge Talks

16：25～17:05
Chair: Masafumi Ito, Tokyo Metropolitan Institute of Gerontology

Molecular hydrogen: a potential mediator of endothelial function
Toru Ishibashi, Haradoi Hospital
Molecular hydrogen inhibits drug-induced aberrant formation of neural circuits in thedeveloping brain
Yasushi Satoh, Yumiko Takaenoki, Tomiei Kazama
National Defense Medical School

Scientific Session 3

17：05～17：53

Chair: Ikuroh Ohsawa, Tokyo Metropolitan Institute of Gerontology
8.

Changes in the hydrogen concentration in the various devices for ingestion of molecularhydrogen
Ryosuke Kurokawa, Shin-ichi Hirano, Tomoki Seo, Bunpei Sato, Fumitake Sato
MiZ Co., Ltd9.

Artificial sulfur hot spring water containing hydrogen
Kazuki Umeda, Yoshiaki Kurita, Yosuke Mukae, Shoichi Okouchi
Hosei Univ. Faculty of Bioscience and Applied Chemistry

10. Active species of hydrogen molecules and antioxidant activities
Shigeki Kobayashi1, Mariko Shinagawa2, Daiki Yasugata2, Toshiyuki Chikuma1,Daisuke Tuchiya2, Tomomitu Hirai3
1Showa Pharmaceutical Univ., 2Toppan Forms Co., Ltd ,3Nikko-Kasei. Co.

11. Physiological isotope effects of deuterium
Maki Shibata1,2, Kensi Koide1,2, Mayumi Takahashi1, Masumi Iketani1,Hideo Kawaguchi2, Ikuroh Ohsawa1
1

Tokyo Metro. Inst. Gerontol., 2Grad. Sch. Life Sci., Toyo Univ.

6

Business Meeting

17：55～18：05
President: Shigeo Ohta, Nippon Medical SchoolBanquet

18：15～20：15

7

DAY 2: March 22, 2015 Sunday
Special Lecture 2

9：10～9：40
Chair: Kinji Ohno, Nagoya University

Molecular Hydrogen in America: research, products, media, and awarenessTyler W. LeBaron1,21Department of Biology, Brigham Young University-Idaho, USA, 2MolecularHydrogen InstituteScientific Session 4

9：40〜10：20
Chair: Mikako Ito, Nagoya University

12. Molecular hydrogen reduces muscle degeneration in mdx mice
Satoru Hasegawa¹, Mayu Fukami², Miki Hashimoto², Masaaki Hirayama², Mikako Ito¹,Kinji Ohno¹
1

Division of Neurogenetics, 2Department of Pathophysiological Laboratory Sciences, Nagoya

Univ. Grad. Sch. of Med.
13. Molecular hydrogen regulates signal transduction and gene expression by modifying thefree radical-dependent reactions
Katsuya Iuchi1, Akemi Imoto1,2, Naomi Kamimura1, Kiyomi Nishimaki1, Harumi Ichimiya1,Shigeo Ohta1
1

Nippon Med. Sch., Dept. Biochem. Cell Biol, 2(Present Address) Kitazato Univ., AlliedHealth Sci., Dept. Clin. Chem.
14. Molecular hydrogen-saturated water attenuates and prevents chronic lung disorder innewborn rats
Takahiro Oshima1, Yukako Muramatsu1,2, Mikako Ito1, Yoshiaki Sato3, Masahiro Hayakawa3,
Kinji Ohno1
1

Neurogenetics, Nagoya Univ. Grad. Sch. of Med., 2Pediatrics, Nagiya Univ. Grad. Sch. ofMed., 3Maternity and Perinatal Care Center, Nagoya Univ. Hospital8

15. Prevention of the brain injury in fetal mice of FIRS (fetal inflammatory responsesyndrome)
Kenji Imai1, Tomomi Kotani1, Yukio Mano1, Hiroyuki Tsuda1, Seiji Sumigama1,
Kinji Ohno3, Shinya Toyokuni4, Hideyuki Takeuchi2, Tetsuya Mizuno2, Akio Suzumura2,Fumitaka Kikkawa1
1

Gynecology and Obstetrics, Nagoya Univ. Grad. Sch. of Med., 2Neuroimmunology,

Research Institute of Environmental Med., 3Neurogenetics, Nagoya Univ. Grad. Sch. of Med.,
4

Pathology and Biological Responses, Nagoya Univ. Grad. Sch. of Med.

Coffee Break

10：20～10：35Special Lecture 3

10：35～11：15
Chair: Shigeo Ohta, Nippon Medical School

Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo
and improves high-density lipoprotein function in patients withhypercholesterolemia: a double-blinded, randomized and placebo-controlled trial
Shucun Qin
Institute of Atherosclerosis, Taishan Medical University, China

Closing Remarks

11：15～11：20
Organizer: Kinji Ohno, Nagoya University9