[Translation]

Share Handling Regulations

Ono Pharmaceutical Co., Ltd.
1-5, Doshomachi 2-chome, Chuo-ku, OsakaChapter I General Provisions
Article 1 (Purposes)
The procedures in connection with the handling of shares of the Company and theexercise of shareholders’ rights shall be governed by laws and regulations, and theregulations adopted by the Japan Securities Depository Center, Inc. (hereinafter referred
to as “JASDEC”) and account management institutions such as securities companies withwhich a shareholder has a book-entry transfer account (hereinafter referred to as“securities companies, etc.”), as well as by these Share Handling Regulations inaccordance with the Articles of Incorporation of the Company.
Article 2 (Administrator of Shareholder Registry)
The Administrator of Shareholder Registry of the Company and the address of its
handling office shall be as follows:
Administrator of Shareholder Registry:
Sumitomo Mitsui Trust Bank, Limited
4-1, Marunouchi 1-chome, Chiyoda-ku, Tokyo
Address of handling office:Stock Transfer Agency Business Planning Dept.
Sumitomo Mitsui Trust Bank, Limited
5-33, Kitahama 4-chome, Chuo-ku, Osaka

Chapter II Entries in the Shareholder Register, etc.
Article 3 (Entries in the Shareholder Register)
1. Changes to items contained in the shareholder register shall be made pursuant tonotices such as a general shareholder notice from JASDEC (excluding notices
prescribed by Article 154, Paragraph 3 of the Act on Book-Entry Transfer ofCorporate Bonds and Shares [hereinafter referred to as the “Book-Entry TransferAct”] [such notices hereinafter referred to as “individual shareholder notices”]).
2. In addition to the provisions of the preceding paragraph, in the case of new shareissuance and other cases specified by laws and regulations, entries or changes shallbe made to the shareholder register without a notice from JASDEC.
3. Entries in the shareholder register shall be made using characters and symbols
specified by JASDEC.
Article 4 (Notifications Pertaining to Items Described in the Shareholder Register)
A shareholder shall give notification of his or her name and address in accordance withthe provisions set forth by JASDEC through securities companies, etc. and JASDEC. The
same shall apply to any changes thereof.
-1-Article 5 (Representative of Corporate Shareholder)
A corporate shareholder shall file one (1) person as its representative through securities
companies, etc. and JASDEC in accordance with the provisions set forth by JASDEC.
The same shall apply to any changes thereof.
Article 6 (Representative of Co-owners of Shares)
Shareholders who co-own shares shall appoint one (1) representative on their behalf, andshall notify the address and the name or the trade name of such representative throughsecurities companies, etc. and JASDEC in accordance with the provisions set forth byJASDEC. The same shall apply to any changes thereof.
Article 7 (Statutory Agent)
Statutory agent such as a person with parental authority or a guardian of a shareholder
shall notify their name and address through securities companies, etc. and JASDEC inaccordance with the provisions set forth by JASDEC. The same shall apply to any changes
and terminations thereof.
Article 8 (Notification of Mailing Address of Non-resident Shareholders, etc. for
Receiving Notices)
1. A non-resident shareholder or their statutory agent shall either appoint a standing
proxy in Japan or designate their mailing addresses in Japan for receiving notices.
2. The name and address of the standing proxy or the mailing address prescribed in thepreceding paragraph shall be notified through securities companies, etc. andJASDEC in accordance with the provisions set forth by JASDEC. The same shallapply to any changes and terminations thereof.
Article 9 (Method for Confirmation through JASDEC)
The notification submitted to the Company by a shareholder through securities companies,etc. and JASDEC shall be deemed to have been submitted by the shareholder themself.
Article 10 (Registered pledgee of shares)
The provisions of this chapter shall apply mutatis mutandis to registered pledgees ofshares.

Chapter III Identification of Shareholders
Article 11 (Identification of Shareholders)
1. In the case where a shareholder (including those to whom the individual shareholder
notice has been issued) submits a request such as to exercise their shareholder rights(hereinafter referred to as the “Request”), a document proving that such Request has-2-been prepared and submitted by the shareholder themself (hereinafter referred to as“Proof Documents”) shall be provided. However, this shall not apply if the Company
can confirm that the Request is from the shareholder themself.
2. The Request submitted by a shareholder to the Company through securities
companies, etc. and JASDEC shall be deemed to have been submitted by theshareholder themself and no Proof Document is required.
3. The Request prepared and submitted by a proxy shall require a power of attorneywith the shareholder’s signature or affixed name and seal, in addition to theprocedures set forth in the two preceding paragraphs. The power of attorney shallhave the proxy’s name and address on it.
4. The preceding paragraphs 1 and 2 shall apply mutatis mutandis to proxies.

Chapter IV Procedure for Exercising Shareholder Rights
Article 12 (Request for Delivery of Documents and Objection Notice)
A request for delivery of documents stating the matters for electronic provision measure,of the reference materials for the general shareholders’ meeting, etc., prescribed in Article325-5, Paragraph 1 of the Companies Act (hereinafter referred to as a "Request for theDelivery of Documents") and an objection notice as prescribed in Paragraph 5 of the said
article shall be made in writing. Provided, however, that the means of making a Request
for the Delivery of Documents through securities companies, etc. and JASDEC shall beas otherwise specified by securities companies, etc. and JASDEC.
Article 13 (Methods for Exercising Rights of Minority Shareholders, etc.)
In case where a shareholder exercises the minority shareholders’ rights, etc. set forth in
Article 147, Paragraph 4 of the Book-Entry Transfer Act directly against the Company,
the shareholder shall request the individual shareholder notice and submit a documentthat has their signature or affixed name and seal on it.
Article 14 (Request for Purchase of Fractional Shares Less Than One Unit of Shares)
In case where a shareholder requests the Company to purchase fractional shares less than
one unit of shares, such request shall be made through securities companies, etc. and
JASDEC in accordance with the rules prescribed by JASDEC.
Article 15 (Determination of Purchase Price)
1. The purchase unit price of fractional shares less than one unit of shares requested forpurchase shall be the closing price on the Tokyo Stock Exchange on the day when arequest pursuant to the preceding article reaches the handling office of the transfer
agent provided for in Article 2 hereof. However, if there is no trading of the shares of
the Company effected on such day or if such day falls on a day when the Tokyo Stock-3-

Exchange is closed, such closing price shall be deemed the amount equivalent to thefirst trading price effected thereafter.
2. The purchase price shall be the purchase unit price prescribed in the preceding
paragraph multiplied by the number of fractional shares less than one unit of sharesrequested for purchase.
Article 16 (Payment of Purchase Proceeds)
1. The Company shall pay the purchase proceeds on the fourth (4th) business day fromthe day immediately following the day on which the purchase price is determined, inaccordance with the rules prescribed by JASDEC, unless the Company otherwise
determines. However, if the purchase price reflects the right to receive dividends
from a surplus or shares arising from a stock split, etc., such purchase proceeds shallbe paid by the record date.
2. A shareholder who requests the Company to purchase the fractional shares less than
one unit of shares may request the payment of proceeds by transfer to their designatedbank account or by cash at Japan Post Bank.
Article 17 (Transfer of Shares Purchased)
The fractional shares less than one unit of shares for which a request for purchase is madeshall be transferred to the transfer account of the Company on the day on which thepayment or payment procedure of the purchase proceeds, as prescribed in the precedingarticle, has been completed.

Chapter V Exceptions for Special Accounts
Article 18 (Exceptions for Special Accounts)
Handling of special accounts including identification of shareholders who have opened
such accounts shall be governed by the provisions stipulated by JASDEC or by themanagement institutions of the special accounts.

-4-Supplementary Provisions
Article 1 (Amendments)
These regulations may be amended by resolution of the board of directors.
Article 2 (Implementation date)
These regulations shall be implemented on September 1, 2022.

Established on November 6, 2008
Enforced on January 5, 2009
Amended on January 8, 2010
Amended on January 11, 2012
Amended on June 10, 2013
Amended on August 1, 2022-5-