GPS Safety Summary Reference No. : JIPS_MSP_CE-JP905_EN

GPS/JIPS Safety Summary
1. SUBSTANCE NAME
Titanium dioxide (CAS No. 13463-67-7)

2. GENERAL STATEMENTSUPER TITANIA™ is ultrafine titanium oxide manufactured by the vapor phase oxidation method
using titanium tetrachloride as the raw material. Ultrafine high-purity titanium oxide with very low
metal impurities and suitable for a wide range of needs including electronic materials and variousfillers.
It is harmful to the human body and causes strong eye irritation. Moreover, it is suspected tohave carcinogenicity. For this reason, it is necessary to wear appropriate protective equipment ina well-ventilated place to protect the eyes and prevent inhalation.

3. CHEMICAL IDENTITY
Item
Chemical orname
Trade name
Other No.

Description
generic Titanium dioxide

Chemical Formula
Other information
Source/References

SUPER TITANIA™
Japan: Chemical Substances Control Law (1)-558
Japan: Industrial Safety and Health Act, existing chemical substanceTiO2
Including nanomaterials based on in-house standards
Section 3 of the SDS issued by Resonac Corporation

4. USES AND APPLICATIONS
Main uses

Electronic materials, various fillers

5. PHYSICAL/CHEMICAL PROPERTIESThe product is an odorless white powder. It is stable for general storage and handling. The productshould be stored indoors in principle and should be stored in a dry, safe place and protected frommoisture.
Physical stateAppearance
ColorOdour
ｐH
Melting point/Boiling point
Flash point
Flammability (solid, gas)
Explosive limits (vol %)Auto-ignition temperature
Vapour pressure
Relative vapour density at20 °C

SolidPowder
WhiteOdourless
3 – 4 (as 2 wt% slurry)
1560 ℃(Anatase type)/ 3000 ℃
No flammability
Non flammableNot available.
No flammableNot available
Not available

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Relative density
DensitySolubility
Partitioncoefficientoctanol/water (Log Pow)
Sources/references

No data available
3.9 g/cm³ Anatase type
Water: < 1 μg/L （Insoluble in water）、And no data available inthe case of other solvent.
n-Not available
Section 9 and 10 of the SDS issued by Resonac Corporation

6. HEALTH EFFECTS
Effect assessment
Acute toxicity (oral)
Acute toxicity (dermal)
Acute toxicity (inhalation: gas)
Acute toxicity (inhalation: vapours)
Acute toxicity (inhalation: dust, mist)
Skin corrosion/irritation
Serious eye damage/eye irritation,
Respiratory sensitisation
Skin sensitisation
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
Specific target organ toxicity — Single exposure,Specific target organ toxicity (repeatedexposure)
Aspiration hazard
Sources/references

Results （GHS Hazard Classification）
Not classified
Not classified
Not applicable
Classification not possible
Not classified
Classification not possible
Category 2 Causes serious eye irritation.
Classification not possible
Classification not possible
Classification not possible
Category 2 Suspected of causing cancer
Classification not possible
Classification not possible
Classification not possible
Classification not possible
Section 2 and 11 of SDS issued by ResonacCorporation• GHS (Globally Harmonized System of Classification and Labelling of Chemicals): A system that classifies chemicals
according to the type and degree of hazards, labels the information, and provides safety data sheets according to
globally harmonized rules.
• Not applicable: Since the priority of physical state, chemical structure, chemical property, and hazard items used inthe GHS classification procedures does not fall under the category, it is not subject to the classification for thecategory.
• Not classified: Sufficient information has been obtained to implement the GHS classification, and as a result of theclassification, it does not fall under any of the hazard categories specified in the GHS. It is considered to be a lowerhazard.
• Classification not possible : There is not enough information for GHS classification, and classification is not possible.

7. ENVIRONMENTAL EFFECTS
Effect assessment
Hazardous to the aquatic environment, shortterm (acute)Hazardous to the aquatic environment, longterm (chronic)
Hazardous to the ozone layer
Sources/references

Results （GHS Hazard Classification）
Classification not possible
Classification not possible
Classification not possible
Sections 2 and 12 of the SDS issued byResonac Corporation

Environmental fate/dynamics
Mobility in soil
No additional information available.
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Persistence/degradability
Bioaccumulation potential
Conclusion about
PBT/vPvB

Sources/references

No additional information available.
Bioconcentration test (common carp, 6 weeks) low
Bioconcentration potential.
The criteria for persistent bioaccumulative and toxic (PBT;
remaining persistently in the environment and possessing highbioaccumulation potential and toxicity) and very persistent andvery bioaccumulative (vPvB; remaining very persistently in theenvironment and possessing very high bioaccumulation potential)
chemicals are believed to inapplicable.
Sections 12 of the SDS issued by Resonac Corporation

8. EXPOSURE
DetalsOccupational exposures

Consumer exposures
Environmental exposures

Precautions

Exposure potentials through main uses
The product is manufactured and used in closed/continuous
process with controlled exposure, or used in synthesis orcompounding operation in closed batches, but there is a potential
for dermal or inhalation exposure in operators in case ofmaintenance, sampling, equipment failure, etc. (PROC2, 3).
During batch and other process operations, there is a potential fordermal and inhalation exposure to operators during maintenance,sampling, filling, emptying, and equipment failure (PROC 4).
There is a potential for dermal and inhalation exposure in
operators during blending/mixing operation in batches in theformulation and manufacture of articles (PROC 5).
During the use of the reagent in a small test laboratory, there is apotential for dermal or inhalation exposure in operators (PROC15).
This product is not used directly by general consumers.
The product is manufactured and used in closed systems or otherpotentially exposed processes. Therefore, in the production
process, the product may be released primarily to the air andwater environment (ERC 1).
If there is a possibility of exposure in other uses, take appropriate
measures with reference to recommended risk management
measures.

9. RISK MANAGEMENT RECOMMENDATIONS
Recommended risk management measures can minimize risks to workers, consumers, and theenvironment from Section 8 exposure scenarios.
DetalsWorkerRisk management recommendations
Technical measures:
The carcinogenic potential of dust inhalation has been identified
for this product. Handle the product in a room with forced general
ventilation using local exhaust ventilation by wearing appropriate
protective equipment to protect operators from dust. Takemeasures as much as possible to prevent dust from adhering toclothes and skin. Install facilities for hand washing and eye
washing, etc., and wash hands and face, etc. thoroughly afterhandling.
Local and general ventilation:
The product should be handled in a place where forced general
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Consumer
Environment

Special notes (emergency
measures in case of leakage,etc.)

ventilation is possible with local exhaust ventilation. In addition,
since there is a possibility of exposure during the transfer
operation to containers, etc., perform the operation in a room
where forced general ventilation is possible with local exhaust
ventilation.
Acceptable concentration:
SUPER TITANIA™: Control concentration 3.0 mg/m3
Titanium oxide: Control concentration 3.0 mg/m3, Japan Society
for Occupational Health 0.3 mg/m3 (nanoparticles), ACGIH(American Conference of Governmental Industrial Hygienists)
TWA 0.2 mg/m3 (nanoscale respirable particulate matter)
Hydrochloric acid/Hydrogen chloride: 2 ppm (maximum allowableconcentration) from Japan Society for Occupational Health, andTWA-STEL (C) 2 ppm from ACGIHManage and control the values below the above values.
Protective equipment:
When handling the product, wear respiratory protective equipment(a certified dust mask [with a collection rate of 95% or higher]),chemically resistant rubber gloves (APF20 [with a protection rateof 95%]), protective glasses, and protective clothing to avoid skincontact. In addition, wear protective gloves, apron, boots, andprotective equipment for head and face depending on the use
status.
[Example of protective equipment]
Respiratory protective equipment: dust mask (mask withcollection rate of 95% or higher)
Hand protective equipment: chemically resistant rubber gloves(APF20 [protection rate 95%])
Eye protective equipment: Goggles
Protective equipment for skin and body: Apron, protective
equipment for head and face, etc.
Precautions:
The operation manager should educate operators about theselection of appropriate protective equipment, proper usage
method, and control method of the work site.
Since the substance is not used by general consumers, thepossibility of exposure to consumers is extremely low.
Install appropriate wastewater treatment facilities and exhaust gas
treatment facilities. In addition, take measures to prevent leakage,and pay attention to periodic confirmation of discharge volume,
daily control, and handling.
Precautions for human, protective equipment, and emergency
measures:In case of leakage, wear appropriate protective equipment(respiratory protective equipment, protective clothing, protective
gloves, and eye and face protective equipment), and remove theproduct using a vacuum cleaner.
Environmental precautions:
Do not discharge product into the environment such as drains orrivers.
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If it leaks, immediately remove it with a vacuum cleaner.
Precautions

For normal handling, emergency response, disposal, andtransportation control measures, refer to sections 4, 5, 6, 7, 8, 13,
and 14 of the SDS issued by Resonac Corporation.

10. STATE AGENCY REVIEW
Hazard assessment
International ChemicalSafety Cards

Situations of review
International Chemical Safety CardICSC: 0338（Titanium dioxide）
https://www.ilo.org/dyn/icsc/showcard.display?p_lang=en&p_card_id=0338&p_version=2
ICSC: 1782（Titanium dioxide; nano-form）
https://www.ilo.org/dyn/icsc/showcard.display?p_lang=en&p_card_id=1782&p_version=2

OECD HPVHigh production volume chemical testing programme
https://hpvchemicals.oecd.org/UI/Search.aspx

NITE-CHRIP（NITE ChemicalRisk Information Platform）
GHS Classification Resultsby the Japanese
Government

https://www.nite.go.jp/en/chem/chrip/chrip_search/srhInput
https://www.nite.go.jp/chem/english/ghs/16-mhlw-0099e.html

11. REGULATORY INFORMATION／GHS CLASSIFICATION AND LABELLING INFORMATION
Regulatory information only in Japan
Applicable laws
Regulatory situations
Industrial Safety andHealth Act

Dangerous or Harmful Substances Subject to Be Indicated theirNames（Article 57 Paragraph (1) of the Act, Article 18 item(ⅰ)
and item(ⅱ) appended Table No. 9 of the Enforcement Order）
Titanium(IV) oxideDangerous Articles and Harmful Substances Whose Names, etc.
Should Be Notified（Article 57-2 of the Act, Article 18-2 item(ⅰ)
and item(ⅱ) appended Table No. 9 of the Enforcement Order）
Titanium(IV) oxide（Cabinet Order Number : 191）
hydrogen chloride（Cabinet Order Number : 98）

Poisonous and Deleterious
Substances Control Act

Not applicable

Water Pollution Prevention
Act

Designated Substances（Article 2, Paragraph 4 of the Act, Article
3-3 of the Enforcement Order)

Air Pollution Control Act

hydrogen chloride
Emission Control Substances (Hazardous Substances) (Article 2,Paragraph (1) 3, of the Act, Article 1 of the Cabinet Order)
chlorine and hydrogen chloride
specified substance（Article 17, Paragraph 1 of the Act, Article 10of the Cabinet Order)hydrogen chloride

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Act on Prevention of Marine
Pollution and Maritime
Disaster

Hazardous liquid substances (Class Z substances) (appendedTable 1 of the Enforcement Ordinance)titanium oxidehydrochloric acid

Foreign Exchange andForeign Trade Act

Row 16 of Appended Table 1of Cabinet Order on Export TradeControl

Act on the Assessment ofReleases of Specified
Chemical Substances in theEnvironment and thePromotion of Management
Improvement and Transfer
Register / PRTR)

Not applicable

Labor Standards Act

Occupational disease chemicals (Article 75, Paragraph 2 of the Act,
Article 35, Appended Table 1-2, Item 4-1 of the Enforcement
Ordinance)
Hydrochloric acid (including hydrogen chloride)
Article 2 of the Act, Article 2 of the Enforcement Ordinance,
Appended Table Dusty worktitanium oxide

Pneumoconiosis Act

UN classification

Not applicable

GHS 分類情報
Hazards
Health hazards

Skin corrosion/irritation, Category 2
Carcinogenicity, Category 2

Labelling Information
Hazard pictograms (GHS)

Signal word (GHS)
Hazard statements (GHS)

Warning
if in eyes: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing (P305+P351+P338).

12. CONTACT INFORMATION
CompanyAddress
Departments
Tel. / Fax

Resonac Corporation
13-9, Shiba Daimon 1-chome, Minato-ku, Tokyo, 105-8518
Japan
Marketing Department, Ceramics Division+81-3-5470-3415/+81-3-3431-6924

13. DATE OF ISSUE / REVISION, ADDITIONAL INFORMATION
Date of issue: December 27, 2022
Revisions:
Date of revision
Revised section
January 1, 2023
3, 6, 10-13

Revised item
update to the latest information

Versionrev.2

The contents are based on the safety data sheet (SDS) revised on January 1, 2023.
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Special instructions: Notification on Precautionary Measures for Prevention of Exposure etc. toNanomaterials (Labor Standards Bureau, Ministry of Health, Labor and Welfare, March 31st,
2009, LSB Notification No.0331013)

14. DISCLAIMER
The safety summary is part of the effort for the voluntary management of chemical substance inthe chemical industry (GPS/JIPS: Japan Initiative of Product Stewardship). The purpose of thesafety summary is to provide information on the safe handling of the product as an overview andnot to provide professional information, such as the risk evaluation process and its impact onhuman health and the environment. This document is not meant to serve as an alternative to risk
evaluation, such as a Safety Data Sheet (SDS) or a Chemical Safety Report (CSR). This safetysummary is being written as accurately as possible based on data such as laws, materials, andinformation available at the time of publication, but it does not include all data. It does notguarantee anything.

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