Kao Corporation
GLOBAL PRODUCT STRATEGY SAFETY SUMMARYAMPHITOL 20HD
This document is a high-level summary intended to provide the general public with anoverview of product safety for this substance. It is not intended to replace the Safety Data
Sheet, which is available from suppliers and should be referred to for full details ofrecommended safety procedures for each type of use. It is not intended to replace orsupersede manufacturer’s instructions and warnings for their consumer products containing
this substance.

1. Substance Identity
Brand Name: AMPHITOL 20HDChemical Name: 1-Dodecanaminium, N-(2-hydroxy-3-sulfopropyl)-N,N-dimethyl-, inner salt
(Main component)
CAS Number: 13197-76-7 (Main component)

2. Uses and Applications
AMPHITOL 20HD is an amphoteric surfactant. It is used in a detergent and body cleansing
agent and others.
For the industrial use, AMPHITOL 20HD is mainly used as emulsifier, and others.

3. Physical/Chemical Properties
AMPHITOL 20HD has no identified physicochemical hazards.
PropertyValue

Physical stateLiquidColour

Light yellow clear

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OdourCharacteristic odourpH

6 – ８ (1% solution)

Density

1.108 g/mL (25℃) (77℉), 1.098 g/mL (40℃)(104℉), 1.087 g/mL (60℃) (140℉)

Melting point-10.5℃ (13.1℉)

Boiling point

No information available

Flash point

Not applicable

Flammability

No information available

Explosive properties

No information available

Self – ignition temperature

No information available

Vapour pressure

No information available

Water solubility

SolubleOctanol-water partition coefficient (log Kow)

No information available

Viscosity

29 mPa.s (25℃) (77℉), 24 mPa.s (40℃)(104℉), 19.5 mPa.s (60℃) (140℉)

4. Human Health Safety Assessment
Consumer: The exposure to AMPHITOL 20HD is at safe levels.
Worker: The repeated exposure of AMPHITOL 20HD does not cause any toxic effects
Effect Assessment
Acute Toxicity
oral/ dermal
Irritationskin/ eyeSensitization
Toxicity after repeated exposure
Mutagenicity
Carcinogenicity
Toxicity for reproduction

2 of 5Result
No acute toxicity after oral/ dermal exposurein practical use
The substance does not cause damage toany organs following single exposure
Undiluted substance causes serious eye
damageBased on the available data, unlikely tocause allergic skin reaction
Unlikely to cause any toxic effects throughprolonged or repeated oral exposure inpractical use
Based on the available data, unlikely tocause genetic defects
Based on the available data, unlikely tocause cancer
Based on the available data, unlikely to bedamaging to fertility or the unborn child

Global Product Strategy Safety Summary – AMPHITOL 20HD

5. Environmental Safety Assessment
The test results with fish, aquatic invertebrates and algae suggest that AMPHITOL 20HDcould cause a harmful effect to aquatic organisms. However, AMPHITOL 20HD is unlikely topersist in the environment because of showing the readily biodegradation. AMPHITOL
20HD is unlikely to cause bioaccumulation by the food chain, because AMPHITOL 20HD isnot PBT/ vPvB.
Effect Assessment

ResultAquatic Toxicity

Based on the available data, likely to cause a harmful
effect for aquatic organisms

Biodegradation

Readily biodegradable
Not persistent in the environment, not bioaccumulating
PBT/ vPvB conclusion*in organisms and not toxic nor very persistent and very
bioaccumulating*PBT=Persistent, Bioaccumulative and ToxicvPvB=Very Persistent and Very Bioaccumulative

6. Exposure
Consumer
The consumer can come into contact with the substance in use of the detergent, the bodycleansing agent and others, but the concentration of AMPHITOL 20HD in use is below thelevel which would give rise harmful effects of concern. When it’s used as the recommended
use, consumer should always read product information before use and follow the label/ use
instructions.
WorkerThe exposure can occur either in AMPHITOL 20HD manufacturing facilities or in the various
industrial facilities when AMPHITOL 20HD is used. Those workers in industrial operations
during maintenance, sampling, testing, or other procedures could be exposed withAMPHITOL 20HD. Only qualified and trained workers handle the undiluted substance. The
manufacturing facilities offer thorough training program for employees and appropriate work
processes, as well as safety equipment (goggles and gloves) in place to present an
unnecessary exposure. Safety showers and eye-wash stations are accessible nearby.
Workers are required to be trained in accordance with the safety measures in the Safety
Data Sheet.
Environment
Since this substance is used extensively, it is discharged to waste water treatment plantsfrom industrial sites such as manufacturing, preparation, handling, storage and use of thesubstance as well as from consumer households. However, the substance is readily
biodegradable, so that it is removed efficiently in waste water treatment plants. The
substance is biologically degraded in the surface water even if it remained slightly in thewaste water. Hence, the chronic exposure to aquatic organisms of the substance is unlikely
to occur. Furthermore, the substance does not accumulate by the food chain, and there is noconcern to human health by the exposure of the substance through environmental pathway.

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7. Risk management recommendations
When you use the substance, make sure to be measured the adequate ventilation. Always
wear appropriate eye protection equipment. Do not eat, drink or smoke where the substanceis handled, processed or stored. Wash hands and skin after contact with the substance.
Wash hands and skin with a large amounts of water and soap, when the substance attaches
to skin (or hair). If the substance gets into your eyes, rinse your eyes thoroughly for several
minutes. If you wear contact lens, and you can take it off easily, take it off and continue torinse your eyes. Contact to a doctor immediately.
Waste water containing the substance must be passed the waste water treatment plants inorder to remove the substance. No specific measures are needed, because it is notexpected to be released into the air.

8. Regulatory Information / Classification and Labelling
Under GHS classification chemical substances are classified in hazards for physicalproperties, human health and environment. The hazard information for industrial products
are transmitted via specific labels and Safety Data Sheet. GHS offers the standardization for
hazard communication. The subjects who could be assumed to be exposed to the substance,workers, consumers, transport workers, and emergency responders, can better understandthe hazards of the chemicals in use through the transmission.

Labeling according to UN GHS
UN GHS is the basis for country specific GHS labeling.
AMPHITOL 20HD may be assigned to following GHS classification.

Classification and Labeling Information
Eye Dam. 2AAquatic Acute 3

Hazard Statements:
H318: Causes serious eye irritation
H402: Harmful to aquatic life

Signal WordWarning
The laws of manufacturing, sale, transport, use and disposal are different among countries
or areas. Details are referred to Safety Data Sheet provided by the supplier.

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9. Conclusion
Though AMPHITOL 20HD is suggested to cause a harmful effect to aquatic organisms,
there is no concern to the environmental organisms due to the rapid biodegradation ofAMPHITOL 20HD. In the PBT/vPvB assessments for AMPHITOL 20HD, the substance isnot PBT/vPvB. Contact with the undiluted AMPHITOL 20HD may cause serious irritation tothe eyes. When handling the substance, workers should follow the standard safetymeasures and refer to the Safety Data Sheet. Consumers will usually not come into contact
with the substance bulk and the substance is used diluted products, therefore, it isconsidered that AMPHITOL 20HD gives rise no hazardous effects to human health.
10. Contact information within company
For further information on this substance or product safety summaries in general, pleasecontact:
Name

Kao Corporation, Global Chemical Business

Telephone number+81-3-5630-7700

Fax number+81-3-5630-7889

E-mail address

chemical@kao.co.jp

Additional information can be found at the International Council of Chemical Associations
portal, found at http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/.
11. Glossary
Acute Toxicity

Adverse effects that result from a single exposure

Biodegradation

Biological degradation of a substance in environments

Bioaccumulation

Accumulation of substances in environments

Carcinogenicity

Action influence to cause a cancer

Toxicity after
repeated exposure

Adverse effects that result from repeated exposure

HazardGlobally Harmonized System of Classification and Labeling ofChemicals
Hazardous property for human health or environments

Mutagenicity

Effects to induce gene mutations

Toxicity forreproduction
Sensitization

Adverse effects for teratogenicity, embryotoxicity, andreproductivity
Inducibility of allergy

GHS

12. Date of issue
19 Dec. 2016
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