This English translation is provided for information purposes only.

Hokkaido University Graduate School of Medicine

Application Guidelines forAugust Examination, 2024 andJanuary Examination, 2025 forDoctoral (PhD) Programin Medicine（For enrollment April 2025 or October 2024）

Hokkaido University Graduate School of Medicine

The amounts of stamps indicated in the application guidelines are theamounts as of April 2024, and the following are scheduled to change according
to the revision of postage rates in the fall of 2024.
The following changes will be made in accordance with the postage rate
revision in the fall of 2024.
Page 8, " Self-addressed Envelope " explanation: "... 344 yen stamps ..."
Page 9, " Self-addressed Envelope " explanation: "... 344 yen stamps ..."
Page 11, "10. Past Entrance Exam Questions" explanation "...250 yen
stamps affixed..."If you are planning to apply for the January Examination, 2025, please be
sure to check the following website of Hokkaido University Graduate Schoolof Medicine for the changed amount before applying.
Websitehttps://www.med.hokudai.ac.jp/en/graduate/admissions/index.html

２Outline of Doctoral (PhD) Program in Medicine
1. Educational Philosophies, Educational Goals, Expectations of students，Basic Policy for Entrant
Selection
Under the basic philosophies of Hokkaido University, “Frontier Spirit”, “Global Perspectives”, “All-round
Education” and “Practical Learning” and the educational philosophies of the Graduate School of Medicine“to lead the world with cutting-edge research in medical science” and “to equip the next generation of
medical researchers and medical professionals with a strong sense of ethics and a well-rounded character tocontribute to the health and welfare of humanity”, the Graduate School of Medicine sets its educational goal
to nurture individuals who possess high ethical standards, highly specialized knowledge, and research andteaching capabilities regarding medicine, life science and social medicine (public health), as well as
individuals who possess the deep insight to meet the diverse, wide range of health and safety requirementsfrom local and international community. The Graduate School of Medicine expects “① students who arewilling to be engaged in research tailored to clarify life phenomena, to overcome diseases, and to improve
human health standards” and “② students who have intellectual curiosity, show the ability to analyze things
logically, persevere as a team, and aspire to work as international leaders in each medical field.” and “③Students who have fundamental reading comprehension in foreign language (English) andwriting skills before enrollment ”
Selection shall be determined based on the comprehensive evaluation of entrance
examinations, academic transcripts, and other relevant documents submitted.
・ The evaluation methods and the evaluation weight and the relationship between
Expectations of Students and the evaluation methods
Matters
Matters
Matters
Entrance exam
Evaluation
Evaluation
related to related to related toclassification
methodweight①②③
Specialized◎✔
✔
general examination

subject
English◎✔

Application○✔
✔
Documents
The mark ◎ indicates elements that are particularly important
The mark ○ indicates elements that are important□ is the Expectations of Students evaluated in the each evaluation methods

2. Expected Competencies, Diploma Policy
Based on the “Educational Goals” of the Graduate School of Medicine, in the Doctoral Program, we aim tonurture highly qualified individuals who play active roles as (i) international researchers in domestic andinternational universities or research institutions, (ii) clinicians and medical scientists in medical institutions
who excel in both clinical techniques and research competence, or (iii) highly specialized professionals
engaged in health services administration and public health in administrative organizations, companies andso on.
In order to develop such human resources, we grant Doctor of Philosophy to those who have attained thecompetencies to continuously contribute to the development of basic medicine, clinical medicine, or social
medicine research through properly understanding the backgrounds or circumstances of medical research,making plans for research theme which are academically and internationally significant or hypotheses whichshould be validated, analyzing the obtained results through verification of the validity and preparing anothertheme or hypotheses.

3. Course Introduction

In order to nurture individuals who attain “Expected Competencies”, we offer interdisciplinary education
beyond the boundaries of existing academic disciplines, aiming at the acquisition of basic knowledge andtechnology of mutually related fields. In addition, to nurture talented individuals responding to the diversified１social needs, we introduce three types of coursework to study systematically through multiple subjects.
Students choose the course that suits best to their purpose.
【Basic Medicine Course】
This course aims to train researchers and educators in medical and life science field. Students acquire broad
expertise required to become independent researchers, learn various research approaches including
techniques for designing experiments, and develop their research capabilities. They are also expected toacquire the competence and skills to apply and utilize their expertise to medical and life science fields withinterdisciplinary approach.
【Clinical Medicine Course】
This course aims to train clinicians who excel in clinical techniques and research competence. Rather thanrelying solely on the traditional research methods of basic medicine using model animals or cells, students
gain the competence they need for research in clinical medicine by applying methods targeting human.
A system of Clinical Collaborative Departments is implemented for the students taking Clinical Medicine
Course. Under this system, students can collect clinical data which may not be available at the university
hospital, and can receive medical research instructions from institutions where advanced and specialized
diagnoses, examinations and treatments are conducted which may not be feasible at the university hospital.
This system combines theory with practice in education provided by multiple instructors including dedicatedinstructors and collaborative leading clinicians.
【Social Medicine Course】
This course aims to train professionals who undertake the task of improvement of health and safety at theregional and international levels. Students start by learning research methods in social sciences including
research ethics, basic and applied statistics, medical informatics and EBM (evidence-based medicine). This
course emphasizes social medicine and preventive medicine, rather than biology and life science. Students
aim at mastering the research approaches and skills that are necessary for research in public health andpreventive medicine.
※ Students should state their preference course when applying and after the admission students will beallocated to courses based on their preference. It is possible to change the course after the admission. (Details
will be informed after the admission.)
4. Course Guidance
The following 3 subjects are offered in the Doctoral (PhD) Program in Medicine.
- Required Core Subjects (Kyoutsu Koa Kamoku)- Required Subjects (Hisshu Kamoku)- Elective Subjects (Sentaku Kamoku)“Required Core Subjects” are offered to cultivate the basic quality in the education at the Graduate School of
Medicine, and are compulsory in all courses. “Required Core Subjects” include “Introduction to Medical
Research” to provide basic and systematic knowledge of medical research, and “Experimental Methods andResearch Designs” to master designing of research, basics of epidemiology and biostatics. In line with
“All-round Education”, one of educational philosophies of Hokkaido University, students learn “Medical
Ethics” which cultivates bioethics for those engaged in medicine, “Presentation Skills I & II” which develops
presentation skills and academic paper writing skills in English, and “Introduction to Translational Research”
which promotes the understanding of bridging research aimed at establishing medical technology or
pharmaceutical products in the clinical practice utilizing the results gained by basic research.
“Required Subjects” are offered according to the educational goal of each course, to acquire not only
in-depth knowledge of specialized research field but also the knowledge of outside extensive fields. In
addition, research work for doctoral thesis will be certified as credits. Furthermore, a supervisor in thelaboratory will be in charge of the subject and carry out exercises for gaining the necessary ability tocomplete the dissertation.
２

“Elective Subjects” are offered to secure flexibility in selecting credits, and enable students to acquire a
broad view and expertise beyond the course and a framework of specialized field.
Subjects

Required Core
Subjects

Basic
Medicine
CourseRequired
Subjects

ClinicalMedicine
CourseSocialMedicine
CourseElective Subjects

Subject
Introduction to Medical ResearchExperimental Methods andResearch Designs
Medical Ethics
Scientific Presentation andCommunication
Presentation Skills I
Presentation Skills II
Introduction to Translational
ResearchResearch Methods in Medical
Sciences I
Research Methods in Medical
Sciences II
Dissertation Research in Medical
Sciences
Research Methods in Clinical
Medicine I
Research Methods in Clinical
Medicine II
Dissertation Research in Clinical
Medicine
Research Methods in Social
Medicine I
Research Methods in Social
Medicine II
Dissertation Research in Social
Medicine
Principles of Medicine
Required Subjects from Other
Courses

Credit1

Details

1
1
1
１
2
１
1
1
10
1
1
10

Take one of these 3
courses and enroll all
the subjects offered bythat course.

1
1
10
［2］

Take 10 credits ormore including 2
credits of Principles ofMedicine offered bybelonging laboratory.

※ As for the subject which credit number is indicated as [number], students can take multiple
choices as far as the chosen subjects belong to different subject titles.
Completion Requirements
Students are required to be enrolled in the Graduate School of Medicine for 4 years or more to complete Doctoral
Program. (Students who achieved superior performance can complete the Doctoral Program as much as 1 year
before the end of the course term.)
Students should acquire 30 or more credits in majored fields, and pass the qualifying review and examination of
the Degree thesis (Dissertation) after receiving required research instruction from the supervisor.
How to take subjects
Students should take 8 credits from Required Core Subjects, 12 credits from Required Subjects they enroll, 10
credits or more including Principles of Medicine offered by belonging laboratory from Elective Subjects.

３Application Guidelines forAugust Examination, 2024 and January Examination, 2025 forDoctoral (PhD) Program in Medicine(For enrollment April 2025 or October 2024)
1. Number of Students Admitted
Medicine: 90 (including a few working students)
Before applying, please contact Student Affairs Office, Graduate School of Medicine at first, because theoffice needs to refer the prospective supervisor for the possibility to accept the applicant. Please be notedthat only those who have been given prior approval from prospective supervisor can apply. For the
information of laboratories, please check “Organization of the Graduate School of Medicine and main
research contents”.
Working students mean individuals who are working at public offices, institutes, hospitals or others andcontinue their service at their work place after enrollment.

2-1. Qualifications of Applicants (April 2025 Enrollment)(1) Those who have graduated or are expected to graduate from a six-year program in Medicine, Dentistry,
Veterinary Medicine or Pharmaceutical Sciences by 31 March 2025.
(2) Those who have completed or are expected to complete 18 years of formal education overseas (with asix-year final program in Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences) by 31
March 2025.
(3) Those who have completed or are expected to complete 18 years of formal education provided byoverseas educational institution by way of distance education (with a six-year final program in
Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences) while residing in Japan by 31
March 2025.
(4) Those who have completed or are expected to complete an undergraduate course of a foreign
institution at an educational institution in Japan (limited to those who have completed 18 years of thesaid foreign country’s curricular education with a six-year final program in Medicine, Dentistry,
Veterinary Medicine or Pharmaceutical Science) which is designated in the said foreign country’s
education system and specifically designated in Japan by the Minister of Education, Culture, Sports,
Science and Technology by 31 March 2025.
(5) Those who have been awarded or are expected to be awarded by 31 March 2025 a degree equivalent
to Bachelor’s degree from overseas university or overseas educational institution by completing fiveor more years of curriculum in Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Science(including completing the said curriculum by overseas school by way of distance education while
residing in Japan or completing the curriculum at an educational institution which is designated in thesaid foreign country’s education system as well as falls into the specification of above (4)).
(6) Those designated by the Minister of Education, Culture, Sports, Science and Technology (see Notes
1&2)(7) Those have been or are expected to be fallen under one of the followings by 31 March 2025 arequalified for application if deemed by Hokkaido University Graduate School of Medicine of to haveacademic ability equal to or greater than university graduates in Medicine, Dentistry, Veterinary
Medicine or Pharmaceutical Sciences. (see Note 2)ⅰ）Those who have been enrolled for four years or more in 6-year program in Medicine, Dentistry,
Veterinary Medicine or Pharmaceutical Sciences Medicine.
ⅱ）Those who have completed 16 years of school education overseas (with a final program in
Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences).
ⅲ）Those who have completed 16 years of formal education provided by overseas educational
institution by way of distance education (with a final program in Medicine, Dentistry, Veterinary
Medicine or Pharmaceutical Sciences) while residing in Japan.
ⅳ）Those who have completed an undergraduate course of a foreign institution at an educational４

institution in Japan (limited to those who have completed 16 years of the said foreign country’s
curricular education with a program in Medicine, Dentistry, Veterinary Medicine or Pharmaceutical
Science) which is designated in the said foreign country’s education system and specificallydesignated in Japan by the Minister of Education, Culture, Sports, Science and Technology.
(8) Those who are deemed by Hokkaido University Graduate School of Medicine under individual
qualification review to have academic ability equal to or greater than university graduates, and will be
24 years of age or older before 31 March 2025. (see Note 2).
Note 1: Those designated by the Minister of Education, Culture, Sports, Science and Technology.
(A) Those who have graduated from a medical or dental faculty of a university under the former University
Ordinance（Imperial Ordinance No. 388 of 1918）after completing a program in medicine or dentistry in thesaid faculty.
(B) Those who have graduated or are expected to graduate from the National Defense Medical College underthe Act for Establishment of the Ministry of Defense (Act No.164 of 1954) by 31 March 2025.
(C) Those who have completed a master’s course or a course of professional graduate school under the School
Education Act (Act No. 26 of 1947) Article 99, paragraph 2 or those who are eligible to be awarded a master’s
degree. (including those who are expected to complete the said course by 31 March 2025), as well as those
who have been enrolled for more than two years in a doctoral course that is not divided into two terms (first
two-year term and second three-year term), have acquired 30 or more credits, have received necessary research
instruction (including those who meet the requirement of the Rules for Degrees [Education Ministry OrdinanceNo.9 of 1953, Article 6, item 1] before it was partly revised by Education Ministry Ordinance No.29 of 1974),
and have been deemed by Hokkaido University Graduate School to have academic ability equal to or greaterthan university graduates in 6-year program in Medicine, Dentistry, Veterinary Medicine or Pharmaceutical
Sciences.
（D）Those who have graduated from or completed one of the programs listed below, and have conducted
research for at least two years at a university or research institute, and are deemed by Hokkaido University
Graduate School to have academic ability equal to or greater than university graduates in Medicine, Dentistry,
Veterinary Medicine or Pharmaceutical Sciences.
a)

Those who have graduated from a university (other than 6-year programs in Medicine,
Dentistry, Veterinary Medicine or Pharmaceutical Sciences).

b)

Those who have completed 16 years of formal education outside Japan.

Note 2: Those who apply under Qualifications of Applicants (6), Note 1 (D), or Qualifications ofApplicants (7) or (8), must undergo Qualification Review. Refer to 3. (4) Qualification Review forfurther information.
2-2. Qualifications of Applicants (October 2024 Enrollment)
Applicants who wish to enroll in October 2024 must indicate such by circling the appropriate box on theapplication form.
(1) Those who have graduated or are expected to graduate from a six-year program in Medicine, Dentistry,
Veterinary Medicine or Pharmaceutical Sciences by 30 September 2024.
(2) Those who have completed or are expected to complete 18 years of formal education overseas (with asix-year final program in Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences) by 30
September 2024.
(3) Those who have completed or are expected to complete 18 years of formal education provided byoverseas educational institution by way of distance education (with a six-year final program in
Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences) while residing in Japan by 30
September 2024.
(4) Those who have completed or are expected to complete an undergraduate course of a foreign
institution at an educational institution in Japan (limited to those who have completed 18 years of thesaid foreign country’s curricular education with a Those who have completed or are expected tocomplete 18 years of formal education overseas (with a six-year final program in Medicine, Dentistry,
Veterinary Medicine or Pharmaceutical Sciences) by 30 September 2024.
５

final program in Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Science) which is designatedin the said foreign country’s education system and specifically designated in Japan by the Minister of
Education, Culture, Sports, Science and Technology by 30 September 2024.
(5) Those who have been awarded or are expected to be awarded by 30 September 2024 a degree
equivalent to Bachelor’s degree from overseas university or overseas educational institution bycompleting five or more years of curriculum in Medicine, Dentistry, Veterinary Medicine or
Pharmaceutical Science (including completing the said curriculum by overseas school by way of
distance education while residing in Japan or completing the curriculum at an educational institution
which is designated in the said foreign country’s education system as well as falls into thespecification of above (4)).
(6) Those designated by the Minister of Education, Culture, Sports, Science and Technology (see Notes
1&2)(7) Those have been or are expected to be fallen under one of the followings by 30 September 2024 arequalified for application if deemed by Hokkaido University Graduate School of Medicine of to haveacademic ability equal to or greater than university graduates in Medicine, Dentistry, Veterinary
Medicine or Pharmaceutical Sciences. (see Note 2)ⅰ）Those who have been enrolled for four years or more in 6-year program in Medicine, Dentistry,
Veterinary Medicine or Pharmaceutical Sciences Medicine by 30 September 2024.
ⅱ）Those who have completed, to complete 16 years of school education overseas (with a final programin Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences) by 30 September 2024.
ⅲ）Those who have completed 16 years of formal education provided by overseas educational
institution by way of distance education (with a final program in Medicine, Dentistry, Veterinary
Medicine or Pharmaceutical Sciences) while residing in Japan.
ⅳ）Those who have completed an undergraduate course of a foreign institution at an educational
institution in Japan (limited to those who have completed 16 years of the said foreign country’s
curricular education with a program in Medicine, Dentistry, Veterinary Medicine or Pharmaceutical
Science) which is designated in the said foreign country’s education system and specificallydesignated in Japan by the Minister of Education, Culture, Sports, Science and Technology.
(8) Those who are deemed by Hokkaido University Graduate School of Medicine under individual
qualification review to have academic ability equal to or greater than university graduates, and will be
24 years of age or older before 30 September 2024. (see Note 2).
Note 1: Those designated by the Minister of Education, Culture, Sports, Science and Technology.
(A)Those who have graduated from a medical or dental faculty of a university under the former University
Ordinance（Imperial Ordinance No. 388 of 1918）after completing a program in medicine or dentistry in thesaid faculty.
(B)Those who have graduated or are expected to graduate from the National Defense Medical College underthe Act for Establishment of the Ministry of Defense (Act No.164 of 1954) by 30 September 2024.
(C) Those who have completed a master’s course or a course of professional graduate school under the
School Education Act (Act No. 26 of 1947) Article 99, paragraph 2 or those who are eligible to be awardeda master’s degree. (including those who are expected to complete the said course by 30 September 2024),
as well as those who have been enrolled for more than two years in a doctoral course that is not divided
into two terms (first two-year term and second three-year term), have acquired 30 or more credits, havereceived necessary research instruction (including those who meet the requirement of the Rules for
Degrees [Education Ministry Ordinance No.9 of 1953, Article 6, item 1] before it was partly revised by
Education Ministry Ordinance No.29 of 1974), and have been deemed by Hokkaido University Graduate
School to have academic ability equal to or greater than university graduates in 6-year program in
Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences.
(D) Those who have graduated from or completed one of the programs listed below, and have conducted
research for at least two years at a university or research institute, and are deemed by Hokkaido
University Graduate School to have academic ability equal to or greater than university graduates in
Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences.
a)

Those who have graduated from a university (other than 6-year programs in Medicine,
Dentistry, Veterinary Medicine or Pharmaceutical Sciences).
６b)Those who have completed 16 years of formal education outside Japan

Note 2: Those who apply under Qualifications of Applicants (6), Note 1 (D), or Qualifications ofApplicants (7) or (8), must undergo Qualification Review. Refer to 3. (4) Qualification Review forfurther information.

3. Application Procedure(1) Application Period[August Examination, 2024]
Tuesday, 9 July 2024 to Friday, 12 July 2024
[January Examination, 2025]
Monday, 18 November 2024 to Thursday, 21 November 2024
Office Hours: 09:00 to 17:00 (JST), excluding Saturday and Sunday * If the applicants send theapplication by post, send by express registered mail. Application documents must arrive at Student
Affairs Office within the application period.
Those who apply under 2. Qualifications of Applicants (6) Note 1 (D), (7), or (8) must undergo
Qualification Review.
Apply for Qualification Review within the application period with all necessary documents describedin 3. (4) Qualification Review. Application deadlines for Qualification Reviews are Thursday, 13 June
2024 for August Examination, 2024 and Tuesday, 29 October 2024 for January Examination, 2025.
(2) Application Documents and Examination Fee
Please request Student Affairs Office for the original booklet “Application Guidelines for August
Examination, 2024 and January Examination, 2025 for Doctoral (PhD) Program in Medicine”,
which includes Application Form and other necessary documents for application.

７

Application Form

Academic Transcripts

Certificate of (expected)
Graduation orCompletion

Prescribed form included in the original booklet.
Please request the original booklet from Student Affairs Office.
Fill in your information and paste your photograph taken within the last 3
months (full-face, 4 x 3cm, applicant’s name printed on back) in the spaceprovided.
Must be issued by a university/college president or Dean.
Those who have entered a graduate school must also submit the transcript
issued by the Graduate School as well.
Those who have graduated or are expected to graduate from Hokkaido
University School of Medicine or completed or are expected to complete theMaster’s Program of Hokkaido University Graduate School of Medicine do notneed to submit this documentation.
If your family name has been changed afterward, please attach the document
such as abstract of your family register, to prove that you have changed yourfamily name.
Applicants who have previously submitted an application as a research student
must also submit a new original. Copy not accepted.
Must be issued by a university/college president or Dean.
Those who have entered a graduate school must also submit the certificate
issued by the Graduate School as well.
Those who have graduated or are expected to graduate from Hokkaido
University School of Medicine, or completed or are expected to complete theMaster’s Program of Hokkaido University Graduate School of Medicine do notneed to submit this documentation.
If your family name has been changed afterward, please attach the document
such as abstract of your family register, to prove that you have changed yourfamily name.
Applicants who have previously submitted an application as a research student
must also submit a new original. Copy not accepted.

*Those who graduated or will graduate from a university in China (excluding
Taiwan, Hong Kong and Macau) must submit the following documents in addition
to a Certificate of (Expected) Graduation (Completion) .
Graduates:
a. Online Verification Report of Higher Education Qualification Certificate（教育部学子注册 案表）b. A certified copy of Graduation Diploma（）and Degree Diploma（学位）that has been authorized by a university/college
Expected Graduates :a. Online Verification Report of Student Record（教育部学籍在告）Obtain documents “a” above by requesting it at “中国高等教育学”:
http://www.chsi.com.cn/xlcx/bgys.jsp.
Also be sure that there are 15 or more days left until the expiration date of the online
verification at the time of its submission.

Examination Card /Photo ID Card

Fill in your information and paste your photograph taken within the last 3
months (full-face, 4 x 3cm, applicant’s name printed on back) in the spaceprovided.
Included in the original booklet.

Self-addressed Envelope

Self-addressed prescribed envelope (23.5×12cm) with 344 yen* stamp affixed
to receive your Examination Card.
８Address Card

Prescribed form to receive the acceptance letter and documents for admission.
Included in the original booklet.

Examination Fee

JPY30,000. Pay by the attached remittance form at Japan Post Bank or otherbanks in Japan, which is attached to the original booklet. 【ATM payment not
accepted】
Government-financed international students (persons receiving MEXT
Scholarship grants) are exempted from this fee but must include a statement tothis effect when submitting the application.

Form to Paste thePayment Certificate

Prescribed form. Included in the original booklet.
On this form paste the payment certificate of examination fee (certificate E)
which is included in the original booklet and to be returned from the bank after
payment.

(If applicable)
Photocopy of Residence Applicants from abroad must submit photocopy of passport.
Card
Applicants for Working Student Admission must submit following additional documents. Please contact
Student Affairs Office for further information.
- Statement of Purpose (A4- paper free format, explaining your preferred laboratory, research plan andfuture goals)- Details of activities (conference presentation, publication, business content).
(3) Applicants with Physical Disability
Physically disabled applicants who require special attention during tests and classes should contact
Student Affairs Office of the Graduate School of Medicine by Thursday, 13 June 2024 for August
Examination, 2024 and Tuesday, 29 October 2024 for January Examination, 2025.
(4) Qualification Review
Those who apply under 2. Qualifications of Applicants (6), Note 1 (D), or Qualifications of Applicants (7)or (8), must undergo Qualification Review. Apply within the application period with all necessary
documents described as follows.
ⅰ) Application Period for Qualification Review[August Examination, 2024]
Friday, 9 June 2024 to Tuesday, 13 June 2024
[January Examination, 2025]
Monday, 30 October 2024 to Tuesday, 31 October 2024
Office Hours: 09:00 to 17:00 (JST), excluding Saturday and Sunday *If the applicants cannot handin to Students Affairs Office, send the application by express registered mail. Application
documents must arrive during the application period.
ⅱ) Application Documents for Qualification Review
In addition to the documents described in (2) above, submit the documents described below.
After receiving the result of Qualification Review, pay examination fee using the attached
remittance form by payment due date. Paste the payment certificate (Certificate E) on the form
included in the original booklet, and mail to the address described in (5) below within (1)Application Period.
Application for
Qualification Review
Self-addressed EnvelopePrescribed form. Included in the original booklet.
Self-addressed envelope (23.5×12cm) with 344 yen* stamp affixed to receive
the results of Qualification Review.

９Submission required
depending on thequalification

Qualificationsof Applicants

Documents to Submit

Certificate of Research
Activity History(6) Note 1 (D)Certificate of research period issued by the university or the
research organization where you engaged in research.

Research Plan
Letter of
Recommendation
Materials to prove youracademic ability to beequal to or greater thanuniversity graduates in
Medicine, Dentistry,
Veterinary Medicine or
six-year program of
Pharmaceutical
Sciences.

(7) i)

A4 paper (around 800words).

(8)(7) i)

From chancellor or dean of the enrolled university. (Freeformat)From the head of research or business institutions, regarding research or business abilities. (Free format)(8)

Certificate of educational background.
Reprints of research papers or other publications.

(8)

Other Materials may be requested if necessary.
ⅲ) Procedure of Qualification Review
Qualification review is conducted by screening submitted documents.
ⅳ) Announcement of Results
Results of Qualification Review will be notified to applicants by postal mail.
(5) Application Documents for both Entrance Examination and Qualification Review should besubmitted to:Student Affairs Office, Hokkaido University Graduate School of Medicine
Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, 060-8638 JAPAN
Phone: +81-(0)11-706-5018

4.

Selection of Entrants
Selection shall be determined based on the comprehensive evaluation of entrance examinations, academictranscripts, and other relevant documents submitted.

5． Date, Time and Place of Entrance Examination
Date[August Examination, 2024]
Tuesday, 20 August 2024
[January Examination, 2025]
Wednesday, 15 January 2025

Time

Subject

10:20-10:30

Introduction

10:30-12:30

English13:30-

Specialized subject

Place
Information of place andexamination card will be sent by
post beforehand.
Will be informed at the day ofthe examination.

6． Notice for Entrance Examination(1) Information regarding place and time of the examination will be notified by postal email with
Examination card. Applicants must be at the designated place by the time .
(2) Use of dictionaries is prohibited in the English language exam.

7.

Announcement of Successful Applicants.
[August Examination, 2024]１０

10:00AM Friday, 6 September 2024 (JST)[January Examination, 2025]
10:00AM Friday, 7 February 2025 (JST)Examinee numbers of successful applicants will be posted on the bulletin board at the main entrance
lobby of the Graduate School of Medicine, as well as on the website of Hokkaido University Graduate
School of Medicine around 10:00AM. A letter of acceptance will be mailed to each successful applicant.
No telephone inquiries about the results of the examination will be accepted.

8.

Admission Procedure(1) Registration Period(excluding Saturday and Sunday)[October 2024 Enrollment]
Thursday, 7 September 2024 to Monday, 11 September 2024
[April 2025 Enrollment]
Monday, 4 March 2025 to Friday, 8 March 2025
(2) Admission and Tuition feesⅰ）Admission Fee: JPY 282,000 (estimate)Those who are expected to complete the Master’s Program of Hokkaido University Graduate
School of Medicine and apply for Doctoral Program continuously, or government-financed
international students (persons receiving MEXT Scholarship grants) are exempted from this fee but
must include a statement to this effect when submitting the application.
ⅱ）Tuition Fee:：Half Year: JPY 267,900 (JPY 535,800/Year) (estimate)*Tuition of the first half-year should be paid, using the payment form which will be sent from the
Graduate School of Medicine in the middle of the following month of the enrollment.
*If the fee is revised, the new one will be adapted accordingly.
ⅲ）Payments of admission and tuition fees could be exempted or postponed. Further information will
be notified to successful applicants.

9.

Important Notice(1) Additional application may be opened in case a vacancy occurred. Although application procedure is
as mentioned in this guideline, refer to updated application guidelines opened in the middle ofFebruary for further precise information. The schedule is as follows.
Application Period for Qualification Review: Thursday, 16 January 2025 to Friday, 17 January 2025
Application Period: Wednesday, 5 February 2025 to Friday, 7 February 2025
Date of Entrance Examination: Wednesday, 19 February 2025
(2) Before filling in a column of the preferred laboratory on the application for admission, refer to“Organization of the Graduate School of Medicine and main research contents” and consult yourfuture supervisor about research contents and plan.
(3) Incomplete application documents will not be accepted nor considered.
(4) Submitted documents cannot be revised.
(5) Examination fee is non-refundable unless 1) the application was not made, 2) application documents
were not accepted due to the documents being incomplete, or 3) double-payments were made. It
takes considerable time for refund. “Payment Certificate E” or “Receipt of Remittance D” includedin the original booklet and to be returned from the bank after payment is required to claim the refund
to Student Affairs Office.
(6) Admission may be cancelled if the application documents contain false information.
(7) Any inquiry regarding admission and examination should be sent by post enclosing a self-addressed
return envelope with a postage stamp affixed.

10.

Past Entrance Exam Questions
Past entrance exam questions of English for the last three years are available. Please request in writing toStudent Affairs office enclosing a self-addressed return envelope (kaku-2 size, 24x33.2cm) with 250 yen*stamp affixed.
１１

11.

Long-Term Study Program
Please read the following page for further information.

12. Use of Personal Information(1) All personal information collected by Hokkaido University will be completely protected in compliancewith the Act on the Protection of Personal Information Held by Independent Administrative Agencies, andthe EU General Data Protection Regulation (GDPR) pursuant to the Hokkaido University Regulations on
Personal Information Management.
(2) Your name, address, and other personal information you provide to the university through application andindividual admissions screening processes will be used solely for ① enrollee selection (application
processing and the screening process), ② the announcement of exam results, ③ admission procedures,④ surveys and research on enrollee selection methods, and ⑤ other related processes.
(3) The personal information in section (2) above will also be used after enrollment, only for those who pass
the exam, for processes related to ① academic affairs (registration, academic guidance), ② student
support services (health management, scholarship applications, dorm admission selection, welfare
services, etc.), ③ job search support services, ④ tuition, ⑤ use of the university library, ⑥ use of
information education facilities, ⑦ confirming your safety and communication in a disaster or
emergency situation, and ⑧ public relations (distributing newsletters, information on events, etc.).
(4) Personal information contained in exam results will be used to conduct surveys and research on enrollee
selection methods.
(5) For recruiting purposes, when we receive a request for information from the Hokkaido University Frontier
Foundation (Kita 8 Nishi 5, Kita-ku, Sapporo, Hokkaido; Tel: +81-(0)11-706-2017) or Hokkaido
University Athletic Union (Kita 17, Nishi 7, Kita-ku, Sapporo, Hokkaido; Tel: +81-(0)11-716-4815), theonly personal information listed in section (2) will be provided for use within the scope of thatorganization’s activities.
(6) The personal information set forth in (2) will be retained for five years from the next academic year of ouracquirement.
(7) The university shall use Article 6, Paragraph 1 (a) of the EU GDPR as the basis for handling personal
information and obtaining consent to use it. Personal information will only be used for the purpose forwhich consent has been given, except when required by laws and regulations.
(8) The consent set forth in (7) may be revoked at any time. However, this does not affect the legal handling of
personal information before consent was revoked.
(9) Individuals who provide personal information may make the following requests to the university based on
the EU GDPR and related laws and regulations:① Disclosure of personal information，② Correction of personal information，③ Erasure of personal
information，④ Limitation of the handling of personal information, ⑤ Objection to the handling of personal
information，⑥ Transfer of personal information to other service providers(10) If you have provided personal information within the European Economic Area, you may file an objection
to a supervisory authority in accordance with Article 51, Paragraph 1 of the EU GDPR if you are
dissatisfied with the university’s handling of your personal information, etc.
(11) Some of the processes in (2)－(5) mentioned above may be outsourced by the university to a contracted
service provider (hereinafter referred to as “contractor”). All or some of the personal information
provided by applicants may be provided to the contractor only as needed to perform the tasks for which it
has been contracted.
(12) This university is subject to Japan’s Law for the Protection of Personal Information Retained by
Independent Administrative Institutions, but not subject to adequacy decisions by the European
Commission.
May 2024
Student Affairs Office of Hokkaido University Graduate School of Medicine
Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, 060-8638, JAPAN
Phone: +81-(0)11-706-5018 ＊Japanese only
d-tanto@med.hokudai.ac.jp

１２

Long-Term Study Program1.

PurposeThe standard term is four years. Long-Term Study Program (longer than four years) is offered for those
who wish to study and acquire a degree through a long-term enrollment due to time limitations.
Applicants are individually screened for eligibility.

2.

Eligibility
Those who have difficulties in completing the program within the standard term due to personal reasons
such as (1) full time jobs, (2) part time jobs (3) child-raising or a long-term nursing care, or (4) visualdisabilities, auditory disabilities, physical disabilities or other disabilities are eligible to apply for thisprogram.

3.

Period of Enrollment
Students in Doctoral program may extend their term of study up to six years, and extension of study term
can be applied by the year as a unit.
Students in a Long-Term Study Program are allowed to have four years leave as well as regular students.

4. Application Procedure(1) Application Period
Please request at the time of application for admission. Application form is available at Student
Affairs Office of the Graduate School of Medicine.
(2) Application Documents
Please submit the following documents to Student Affairs Office of the Graduate School of
Medicine.
ⅰ) Application for the Long-Term Study Program (Form 1-1)ⅱ) Reasons to apply to the Long-Term Study Program (Form 2)ⅲ) Study plan of the Long-Term Study Program (Form 3)ⅳ) Documents to prove the need for the Long-Term Study Program
5. Shortening or re-extension of Long-Term Study Program
When deemed necessary by the Graduate School of Medicine, study term of Long-Term Study Program
could be either shortened or re-extended once during the program.
Please contact Student Affairs Office of the Graduate School of Medicine for further information.
6. Tuition Fees
Annual tuition fee of the Long-Term Study Program is determined by dividing the total fees of the regularprogram of standard term (annual fee×2 years) by the number of years allowed for the Long-Term Study
Program. Tuition fee is non-refundable, and the tuition already been paid will not be adjusted.
* Please do NOT pay tuition fee of the long-term study program before receiving a notice ofdetermination.

１３

※Organization of the Graduate School of Medicine and main research contents
Academic advisor

Department
Professor

HATAKEYAMA Shigetsugu 2. Nano structures controlling organelle dynamics

Medical Chemistry

Professor

HATAKEYAMA Shigetsugu 2．Intracellular signal in cancer and immune system

3. Molecular bases of cancer therapeutic resistance
1．Ubiquitin system in protein degradation

Biochemistry

AnatomyResearch contents
1. Cell integrity based on cellular metabolisms and nuclear geometry

Molecular Biology

Anatomy and Embryology Professor
Histology and Cytology

Professor

Cell Physiology

Professor

Physiology
Systems Neuroscience

Professor

Neuropharmacology

Professor

Cellular and Molecular
Pharmacology

Professor

Pharmacology

Pathology

Professor

Pathology
Cancer Pathology

Professor

Professor
Diagnostic Pathology

Associate
Professor

Immunology

Professor

Microbiology and
Infectious Diseases

Professor

HygieneProfessor

Public HealthProfessor

Forensic Medicine

Professor

Health Care Policy

Professor

Microbiology and
Immunology

Biostatistics
Social Medicine

Professor
Associate
Professor

Medical Education andGeneral Medicine

Professor

Regulatory Science

Professor

3．Functional analysis of proteins/lipids by mass spectrometry
1．Visualization of expression and localization of neural signaling molecules
2．Glial roles in neural development and function
3．Molecular mechanisms for synaptic circuit development
1. Anatomy and function of central nervous system
FUJIYAMA Fumino
2. Elucidation of Parkinson's disease
1．Visualization of cell functions using fluorescence bioimaging
2．Spatiotemporal regulation of intra- and intercellular signal transduction
OHBA Yusuke
3．Regulation of membrane dynamics
4．Development and application of fluorescent biosensors
1．Neural control of voluntary movements
2．Functional analysis of the frontal cortex
TANAKA Masaki
3．Functional analysis of the basal ganglia
4．Functional analysis of the cerebellum
1．Neuropharmacological studies of the histaminergic nervous system
2．Analysis of neuropeptides in wakefulness
3．Drug development targeting sleep disorders
4．Molecular biology of hyaluronic acid
YOSHIKAWA Takeo
5．Optical imaging of learning-induced neural circuit reorganization
6．Neural basis of autism spectrum disorder and social behavior
7．Cognitive mechanisms of virtual reality
8．Development of novel neural activity imaging techniques
1. Analysis of the effects of tobacco smoke components on cellular functions
YOSHIKAWA Takeo
2. Research on neutrophil activation and its control mechanism
3. Elucidation of toxicological mechanisms and pathophysiological effects of environmental chemicals
1．Research on inflammation and cancer
2．Research on inflammation and tissue regeneration
3．Mechanisms of autoimmune and inflammatory diseases
TANIGUCHI Koji
4．Research on tight junction
5. Development of new cancer-on-chip to elucidate the pathophysiology of intractable cancer
6．Human pathology and surgical pathology
1. Research on diagnostic and surgical pathology
2. Cancer progression, cancer stem cells, and therapeutics.
3. Profiling analysis of various diseases.
TANAKA Shinya
4. Bioimaging and rapid-immunohistochemistry.
5. Biomaterial for analysis of cellular reprogramming.
6. NGS-based research on brain tumor and sarcoma.
7. Student-oriented innovative research.
1．Diagnostic surgical pathology (including cytopathology)
TANAKA Shinya
2．Application of molecular studies in diagnostic pathology
3．Quality control and standardization in pathology laboratories
TOMARU Utano
4．Clinicopathologic analysis of human malignancy
1. Host protection mediated by TLR and NLR family proteins
2. Role of the innate immune system in the onset of infection and inflammatory diseases
3. Nod2-dependent intestinal mucosal homeostasis and pathogenesis of Crohn’s disease
KOBAYASHI Koichi
4. CITA/NLRC5: a key regulator of MHC class I genes
5. Mechanisms of immune evasion by cancers
6. Development of novel biomarkers and immunotherapies for cancer patients
7. Vaccine development against cancer and coronaviruses using a novel vaccine technology
1．Studies on viral and host factors involved in the propagation of hepatitis virus (HBV, HCV)
2．Studies on the mechanism of pathogenicity of virus infection through molecular
KOBAYASHI Koichi
biological analysis and animal experimentation
3．Studies on the diagnosis and drug discovery of viral infection (Coronavirus, Flavivirus)
4．Epidemiological and molecular biological studies on zoonotic diseases (Hantavirus, Flavivirus)
1. Environmental epidemiological studies
2. Quasi-experimental assessment of population-level health interventions (interrupted time series,
instrumental variables)
UEDA Kayo
3. Emergency preparedness for climate change, natural disasters, and infectious diseases in healthcare facilities
4. Epidemiological study on behavioral and psychological symptoms of dementia
5. Assessment of health effects of climate change and global environment
1．Studies on diet, physical activity, social environment and physical and mental health in adults and elderly
2．Study of factors related to the health and development of children from conception
TAMAKOSHI Akiko
3．Research on infertility prevention and treatment support
4. Study on post COVID-19 condition
1．Studies on medico-legal diagnosis of cause of death, postmortem interval, wounds, asphyxia, identification
MATOBA Kotaro
and postmortem CT diagnosis.
2．Studies on the mechanisms of generation concerning exogeneous unusual findings.
1. Research on medical and long-term care delivery systems in an aging society with a declining population
2. Research on countermeasures against cancer and other diseases
KOMOTO Shigekazu
3. Epidemiological research for the planning, monitoring, and evaluation of healthcare policies
4. Research on the use of innovations to promote Well-being
5. Research on health technology assessment
1. Multivariate survival analysis
2. Development and evaluation methodology for diagnostic method and clinical prediction model
HATAKEYAMA Shigetsugu
3. Development and application of clinical trial design
YOKOTA Isao
4. Joint model of longitudinal data with flexibility
5. Clinical epidemiology using big-data and public database
1． Development of innovative teaching methods and materials
2． Development of innovative evaluation methods
TAKAHASHI Makoto
3． Studies on factors that affect learning behavior
4. Studies on factors that affect physicians' carrier selection
1． Studies on data necessary for the development of advanced biological medicines
ARATO Teruyo
2． Studies on developmental strategy for orphan drugs
3． Studies on post marketing surveillance of pharmaceuticals and medical devices

WATANABE Masahiko

Academic advisor

Department
Translational Research
Manegement

Professor

SATO Norihiro

Patient Safety

Professor

NASUHARA Yasuyuki

Health Data Science

Professor

ITO Yoichi

Clinical Genetics andMedical Ethics

Professor

YAMADA Takahiro

Respiratory Medicine

Professor
Professor

KONNO Satoshi
SAKAKIBARA Jun

Rheumatology,
Endocrinology and
Nephrology

Professor
Professor

ATSUMI Tatsuya
NISHIO Saori

Gastroenterology andHepatology

Professor
Professor

SAKAMOTO Naoya
ONO Shoko

Professor
Associate
Professor

ANZAI Toshihisa
NAGAI Toshiyuki

Medical Oncology

Professor

KONNO Satoshi

Hematology

Professor

TESHIMA Takanori

Professor

ASAKURA Satoshi

Cardiovascular Medicine

Internal Medicine

Health Care Medicine

Research contents
1．Methodology for clinical research
2．Data manegement of clinical trial
3．Manegement of cell processing for cell therapy and regenerative medicine
4．Methodology for translational research support
1. Research on the methodology about system approach to patient safety
2. Research on the methodology for cultivating talented risk managers in hospitals
3. Research on the methodology about standardization of medical accident investigation
1. Studies on the methodology of clinical trials
2. Studies on the methodology of drug safety data analysis
3. Studies on the multivariate data analysis
1. research on disclosure of secondary findings in genomic medicine
2. Research on newborn screening and genetic counseling
3. Research on tele-medicine in genetic counseling
4. Research on genetic counseling in presymptomatic genetic testing
5. Research on providing systems for prenatal genetic testing and genetic counseling
1. Prospective cohort studies of asthma and/or COPD
2. Research on molecular mechanisms, diagnosis, and treatment of thoracic malignancies
3. Research on molecular mecahnisms of chronic airway disease and/or diffuse lung disease
4. Basic/clinical research on pulmonary hypertension and cardiac sarcoidosis
5. Basic / clinical research on respiratory infectious diseases
1．Basic and clinical research on autoimmune disorders
2．Research on the pathophysiology, diagnosis and therapy of diabetes, obesity and dyslipidemia
3．Research on the pathophysiology and therapy of endocrine diseases
4．Basic and clinical research on renal diseases
1．Research for pathophysiology, diagnosis and treatment of liver diseases
2. Research for pathophysiology, diagnosis and treatment of pancreatobiliary diseases
3. Research for pathophysiology, diagnosis and treatment of malignant tumor of digestive system
4．Research for pathophysiology and treatment of inflammatory bowel diseases
5．Research for pathophysiology, diagnosis and treatment of digestive diseases
1．Reasearch on pathophysiology, diagnosis, and treatment for ischemic heart disease
2．Molecular biological and clinical reasearch on pathophysiology and treatment for heart failure
3．Reasearch on etiology, diagnosis, and treatment for cardiomyopathy
4．Reasearch on molecular and genetic basis, diagnosis, and treatment for lifestyle disorder
5．Reasearch on etiology, diagnosis, and treatment for arrhythmia
6．Development of non-invasive technique for diagnosis of heart disease
1．Research on diagnosis and treatment of malignant tumors
2．Research on molecular pathophysiology, diagnosis and treatment of lung cancers and mediastinal tumors
3．Research on molecular pathophysiology, diagnosis and treatment of tumors of the digestive organs
4．Research on cancer drug therapy
5．Research on molecular targeting therapy of cancer
6． Research on genome analysis, companion diagnostics and precision medicine of cancer
1．Research on molecular pathogenesis, diagnosis, treatment of hematological malignancies
2．Basic and clinical research to improve outcome of hematopoietic stem cell transplantation and immune celltherapy
3．Basic research to understand cellular & molecular biology of hematopoiesis
4. Basic and clinical research on cell therapies against viral infections and malignant diseases
5．Pathogenesis, diagnosis, and treatment of immunodeficiencies, including AIDS
6．Reserch to improve safety and efficacy of blood transfusion
7. Research on platelet function, blood coagulation and fibrinolysis
1．Research for impaired health caused by stresses
2．Research for evidence based medicine in health examination
3．Research for occupational mental health
4．Research for adolescent mental health

Clinical Cancer Genomics

Professor

KINOSHITA Ichiro

Radiation Oncology

Professor

AOYAMA Hidefumi

Diagnostic Imaging

Professor

KUDO Kohsuke

Radiology

5．Research for therapeutic interventions of mental disorders
1. Research for cancer genomics
2. Research for genomic abnormality of cancer
3. Research for epigenetic alteration of cancer
4. Development of novel biomarker on cancer
5. Research for molecular targeted therapy on cancer
1．Research for external irradiation
2．Research for high precision X ray therapy
3．Research for Particle therapy and Proton therapy
4．Research for medical physics
5. Research for radiobiology for radiotherapy
1．Diagnostic radiology using CT, MRI, ultrasound, and nuclear medicine
2．Vasicular imaging and interventional radiology
3．Radioisotope treatment
4．Imaging analysis of tracer kinetics and artificial intelligence
5．Synthesis of contrast media and radiopharmaceuticals
6．Molecular imaging using stable isotopes and radio isotopes

Academic advisor

Department

Research contents
１．Basic research and treatment on the surgical GI tract and HPB diseases.
２．Development of endoscopic and/or robotic surgery for the GI tract and HPB diseases.
３．Study for the pathogenesis and management of transplant immunology

Gastroenterological
Surgery I

Professor

TAKETOMI Akinobu

４．Research for the improvement of organ preservation
５．Clarification of pathogenesis and development of new strategy of cell transplantation
６．Artificial Intelligence (AI) applied research in the field of gastroenterological surgery
７．Study of the surgical education and surgical training
８．Basic research and treatment on pediatric surgical oncology and pediatric hepato-biliary diseases

Gastroenterological
Surgery II

Professor
Associate
Professor

HIRANO Satoshi
SHICHINOHE Toshiaki

Surgery
Professor
Renal and Genitourinary
Surgery
Associate
Professor

TAKETOMI Akinobu
ABE Takashige

Cardiovascular Surgery

Professor

WAKASA Satoru

Breast Surgery

Professor

TAKAHASHI Masato

Thoracic Surgery

Professor

KATO Tatsuya

Anesthesia andPerioperative Medicine

Professor

MORIMOTO Yuji

Acute and Critical Care
Medicine

Professor

WADA Takeshi

Orthopedic Surgery

Professor

IWASAKI Norimasa

Plastic andReconstructive Surgery

Professor

YAMAMOTO Yuhei

Rehabilitation Medicine

Professor

MUKAINO MasahikoSports Medicine

Professor

KONDO Eiji

Anesthesiology andCritical Care
Medicine

Reconstructive
Surgery andRehabilitation
Medicine

９．Basic and clinical research on the function of pediatric digestive system
1．Clarification of pathophysiology and development of surgical treatments of themalignancy of the digestive system
2．Development of endoscopic surgery and its devices
3．Clinical researvh for perioperative management of highly invasive digestive surgeries
4. Study for multidisciplinary treatment of pancreato-biliary cancer
5．Molecular research on biomarkers associated with oncological malignancy
6．Exploring translational research on immunotherapy
7．Analysis of immune responses in tumor microenvironments
8．Study of gene therapy for intractable cancers
9. Study for surgical education
10. Study for bariatric and metabolic surgery
1．The mechanism of development of detrusor overactivity associated with lower urinary tract obstruction
2．Neural transmitted pathway at the bladder stimulation
3．The development of chronic rejection in transplanted kidney
4．The analysis of immunology in renal transplantation and development of the treatment of
immunological regulation
5．The mechanism of carcinogenesis and progression in kidney cancer
6．The mechanism of metastasis and progression of urothelial cancer
7．QOL study on the treatment of prostate cancer
8．The development of minimal invasive surgery
1．Research on surgery for severe heart failure
2．Research on surgery for functional mitral regurgitation
3．Research on myocardial protection
4．Research on cold preservation and autophagy in the heart
5．Metabolic disturbances in atrial fibrillation
6．Endovascular stent graft therapy for aortic diseases
1．Research on biological characteristics in breast cancer
2．Research on endocrine therapy in breast cancer
3．Research on mechanisms of breast cancer development and prevention
4. Research on the development of new breast cancer screening methods
5. Research on the development of breast cancer surgical methods
6. Research on the perioperative drug therapy for breast cancer
7. Research on drug therapy for metastatic breast cancer
8. Research on hereditary breast cancer
1．Development of minimally invasive thoracic surgery
2．Surgery in multimodality thearapy for lung cancer
3．Lung transplantation
4．Photodynamic therapy using nanoparticle for thoracic malignant tumors
5．Development of early diagnosis and molecular targeted therapy using next generation sequence for lungcancer
6. Photoimmunotherapy for lung cancer
7. Therapy for malignant mesothelioma and dissemination of cancer
1．Cerebral protection and resuscitation
2．Care and Cure for the whole body against invasive biological stress
3．Neurotoxicity by anesthetics
4．Mechanism of postoperative cognitive dysfunction
5．Mechanism and treatment of pain
6．Mechanism of respiratory cycle and effect of drugs
7． Hyperbaric oxygen therapy
8．Patient management system in the operating room and the medical economics
1．Elucidation of the pathophysiology of host responses to various insults and establishment of their control
methods
2．Multiple organ dysfunction syndrome –pathophysiology and treatment3．Critical care medicine
4．Cardiopulmonary cerebral resuscitation
5．Toxicology
6．Disaster medicine
7．Medical, transportation, and information system for acute medicine
8．Traumatology
1．Elucidation of pathology and development of therapeutic strategy for arthritis
2．Identification of role of glycans in bone and cartilage metabolism
3. Study of pathology and development of therapeutic strategy for osteoporosis
4．Clarification of pathology and development of therapeutic strategy for intervertebral disc degeneration
5. Biomechanical study for pathology and treatment options of musculoskeletal diseases
6. Research about pathology and treatment strategy for spinal cord and peripheral nerve diseases
7．Development of novel analytic tools for musculoskeletal diseases using AI
8．Research about genetic and epidemiologic aspects of musculoskeletal diseases
9. Development of regenerative medicine for musculoskeletal diseases
1．Translational research in wound healing
2．Translational research in treatment of keloid
3．Development of surgical technique in free tissue transfer
4．Basic research in surgical oncology
5．Translational research of angiogenesis of vascular and lymphatic vessel
6．Regenerative medicine based on tissue engineering method
7．Development of therapeutic technique in cranio-maxillo-facial surgery
1. Research on motion analysis of movement disorders
2. Research on activity monitoring
3. Research on functioning statistics for daily life
4. Research on telerehabilitation
5. Research on assessment methods for cognitive impairment
1. Motion analysis of athletes for performance improvement
2. Development of reconstruction surgery for osteoarthritis
3. Tissue regeneration of joints
4. Elucidation of remodeling mechanism of soft tissue
5. Medical application of synthetic polymer gel
6. Development of advanced treatment technology for musculoskeletal disorderAcademic advisor

Department

Pediatrics

Professor
Professor

MANABE Atsushi
CHO Yuko

Reproductive andDevelopmental
MedicineSensory Organ
Medicine

Neurological
DisordorObstetrics andGynecology

Professor

WATARI Hidemichi

Dermatology

Professor

UJIIE Hideyuki

Professor
Otolaryngology−Head andNeck Surgery
Associate
Professor

HOMMA Akihiro
NAKAMARU Yuji

Ophthalmology

Professor

ISHIDA Susumu

Psychiatry

Professor

YABE Ichiro

Neurosurgery

Professor

FUJIMURA Miki

Professor

YABE Ichiro

Neurobiology

Professor

KAMIYA Haruyuki

Immunobiology

Professor

SEINO Kenichiro

Psychoimmunology

Professor

MURAKAMI Masaaki

Molecular Mechanisms

Professor

NODA Nobuo

Stem Cell Biology

Professor

KONDO Toru

Biomedical Oncology

Professor

SONOSHITA Masahiro

Neurology

Medical Biology

Immunology

Pathological
Oncology

Research contents
1. Establishing methods for early diagnosis of primary immunodeficiency diseases.
2. Molecular epidemiological studies on macrolide-resistant mycoplasma pneumoniae
3. Clinical and molecular study for diagnosis and management in pediatric hematology and oncology.
4. Clinical and molecular study in pediatric stem cell transplantation and cell therapy.
5. Molecular analysis of pediatric endocrine disease.
6. Pathological analysis and therapeutic development using neurological disease model animals.
7. Histopathological analysis on the role of activated glomerular parietal epithelial cell in childhood kidneydisease.
8. Development of a Mitochondrial Drug Delivery System for Myocardial Regeneration Therapy.
9. Study to improve outcome of neonatal chronic lung disease.
10. Basic and Clinical study in inborn errors of metabolism.
1．Basic studies on the physiology of fetus and amnion
2．Clinical studies on the antenatal diagnosis and fetal therapy
3．Studies on the development of new strategy for the management of complicated pregnancies
4．Clinical studies on the treatment of infertility
5．Intrafollicular physiology
6．Molecular mechanism of genesis and metastasis of uterine cancer
7．Chemoresistance of female reproductive cancer
8．Molecular mechanism of placental growth and differentiation
9. Development of novel molecular-targeting therapy for ovarian cancer
10. Establishment of new effective screening method for cervical cancer
1．Molecular biological research of epidermis
2．Research on pathophysiology, diagnosis and treatment of genetic skin disorders
3．Research on pathophysiology, diagnosis and treatment of autoimmune blistering skin diseases
4．Research on pathophysiology, diagnosis and treatment of malignant skin tumors
5．Research on pathophysiology, diagnosis and treatment of atopic dermatitis
6．Research on tissue engineering and wound healing
7．Research on novel therapeutic modalities for genetic skin disorders
1． Basic research and clinical analysis for pathogenesis of sensorineural hearing loss
2． Basic research and clinical analysis of sensorineural hearing loss by viral infection
3． Basic research and clinical analysis of nasal allergy
4． Basic research and clinical analysis of Eosinophilic chronic rhinosinusitis
5． Immunological approach for head and neck cancer
6． Basic research and clinical analysis of chemotherapy for head and neck cancer
7．Molecular biologic studies on head and neck cancer
1．Retinal cell biology
2．Ocular Immunology and inflammation
3．Ocular neuroprotection
4．Ocular oncology and pathology
5. Pathophysiology and treatment of ocular surface disease
6．Ocular circulation and metabolism
1．Psychopathology of psychiatric diseases
2．Development of new psychotherapy techniques
3．Development of new diagnostic techniques and new treatment of epilepsy
4．Molecular genetic study of psychiatric diseases
5．Development of animal models of psychiatric diseases and neuroscience
6．Development of new psychotropic drugs and psychopharmacology
7．Neuroimaging in psychiatric diseases
8．Neurophysiological and neuropsychological study of psychiatric diseases
1． Basic and clinical research on malignant glioma
2．Basic and clinical research on cerebrovascular disorders
3． Basic and clinical research on spinal cord disorders
4．Translational research on CNS regeneration
5． Surgical anatomy of skull base surgery
6． Genetic research on cerebrovascular disorders
7．Cerebral blood flow and metabolism
8．Clinical research on pediatric neurosurgery
1．Molecular biology and genetics for neurological disorders
2．Immunohistochemistry of muscles and peripheral nerves
3．Basic studies for the disease mechanism and therapeutic approach in neuro-immunological disorders
4． Biomarkers in neurological disorders
5．Clinical neuroelectrophysiology
6．Cogitive brain function
7．Neuroepidemiology
1．Neurobiology of axon
2． Neurobiology of synapse
1．Tumor Immmunology
2．Transplant Immunology (including studies of xenotransplantation using gene modified pigs)
3．Study and development of cell therapy for inflammatory diseases
1. Molecular mechanism for T cell-specific autoimmune disease development by the gateway reflexes
2. Bioelectronic medicine by the gateway reflexes and the VNS
3. Molecular mechanisms underlying inflammation development via the IL-6 amplifier activation
4. Research for functional roles of SNPs asscoiated with chronic inflammatory diseases (the IL-6 amplifier)5. Development of novel drugs and biomarkers for diseases associated with chronic inflammation (the IL-6
amplifier)
1. Molecular mechanism of autophagy
2. Molecular mechanism of life phenomena regulated by liquid-liquid phase separation
3. Elucidating the molecular functions of biomolecules based on their structure
1． Molecular mechanism involved in the maintenance and differentiation of neural stem/precursor cells
2．Molecular mechanism of neural stem/precursor aging
3．Characterization of cancer stem cells and analysis of their therapeutic targets
4．Relationship between neural stem cells and age-related disorders.
1. Studying how cancers develop
2. Elucidating the mechanisms of how drug resistance occurs in cancer
3. Generating novel anti-cancer therapeutics