北海道大学大学院理学研究院附属ゲノムダイナミクス研究センター໭ᾏ㐨኱Ꮫ ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮ ᴫせ
㸰㸮㸰㸯

概
要

Hokkaido University, Faculty of Science
Genome Dynamics Research Center2021 ᖺᗘᴫせࡢⓎ⾜࡟࠶ࡓࡗ࡚
 ᙜࢭࣥࢱ࣮ࡣࠊᖹᡂ  ᖺ  ᭶࡟ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛ࠊື≀ᰁⰍయඹྠ฼⏝㒊㛛ࠊ㑇ఏᏊᐇ㦂ඹྠ฼⏝㒊㛛ࡢ  㒊㛛࡛ᵓᡂࡉࢀࡿᩍ⫱◊✲ඹྠ฼⏝᪋タ࡜ࡋ࡚Ⓨ㊊ࡋࡲࡋࡓࠋྛ㒊㛛ࡣྛࠎࠊᪧᐇ㦂⏕≀ࢭࣥࢱ࣮ࠊᪧ⌮Ꮫ㒊㝃ᒓື≀ᰁⰍయ◊✲᪋タࠊᪧ㑇ఏᏊᐇ㦂᪋タ࠿ࡽᨵ⤌ࡉࢀ࡚ࡁࡓṔྐࢆࡶࡗ࡚࠾ࡾࠊ⌧ᅾࡢᙜࢭࣥࢱ࣮ࡢ୺࡞άື࡜ࡋ࡚ࠊ㏆஺⣔ࣛࢵࢺ࣭࣐
࢘ࢫࡢ⣔⤫ಖᏑࠊ⏕≀⣔ᐇ㦂ᐊ࣭㣫⫱ᐊ࣭ᐇ㦂ᶵჾ㢮ࡢ⥔ᣢ⟶⌮࡜฼⏝⪅࡬ࡢᥦ౪࡞࡝ࠊᚑ
᮶ࡢᶵ⬟ࢆ⏕࠿ࡋࡓᨭ᥼஦ᴗࢆ⾜ࡗ࡚ࡁࡲࡋࡓࠋࡲࡓࠊᙜࢭࣥࢱ࣮ࡢ඲ᩍဨࡀ኱Ꮫ㝔⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ㒊㛛࡟ᡤᒓࡋࠊࡑࡢᩍ⫱◊✲࡜ᙜࢭࣥࢱ࣮ࡢ㐠Ⴀࢆවᢸࡋ࡚࠸ࡲࡍࠋᪧ᪋タᘓ≀ࢆ౑⏝ࡋ࡚࠸ࡿࡓࡵࠊᐇ㦂⏕≀ඹྠ฼⏝㒊㛛ࡣࢭࣥࢱ࣮ᮾᲷࠊࡑࡢ௚ࡢ  㒊㛛ࡣࢭࣥࢱ࣮すᲷ࡟ศ࠿ࢀ࡚◊✲ᨭ᥼άືࢆ⾜ࡗ࡚࠸ࡲࡍࡀࠊࡼࡾຠ⋡ⓗ࡞ࢭࣥࢱ࣮㐠Ⴀࡢࡓࡵ࡟ࠊ୍య
໬ࡋࡓᘓ≀࡜ᶵ⬟ࢆᵓ⠏ࡋ࡚࠸ࡁࡓ࠸࡜࠸࠺ᑗ᮶ᵓ᝿ࡀ࠶ࡾࡲࡍࠋ ࡲࡓࠊᩥ㒊⛉Ꮫ┬ࡢࢧ࣏࣮ࢺ࡟ࡼࡾࠊ᪥ᮏ඲ᅜࡢ◊✲ᶵ㛵࡟ಖ⟶ࡉࢀ࡚࠸ࡿ㈗㔜࡞⏕≀㑇
ఏ㈨※ࢆ⅏ᐖ࡟ࡼࡿᦆኻ࠿ࡽᏲࡿࡓࡵࠊ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ㸦,%%3㸧ࡀ㐍ࡵࡽࢀ࡚࠾ࡾࠊᙜࢭࣥࢱ࣮ࡣ඲ᅜ࡟  ࡘ࠶ࡿ኱Ꮫࢧࢸࣛ࢖ࢺᣐⅬࡢ  ࡘ࡜ࡋ࡚ࡶࡑࡢ㔜せ࡞ᙺ๭ࢆᢸࡗ࡚࠸ࡲࡍࠋᖹᡂ  ᖺ  ᭶࡟㉳ࡁࡓᮾ᪥ᮏ኱㟈⅏࡟ࡼࡾࠊከࡃࡢ◊✲ᶵ㛵࡛⏕≀ᮦᩱ࣭㑇ఏ㈨※ࡀኻࢃࢀ◊✲ࡢ⥅⥆࡟ᨭ㞀ࢆࡁࡓࡋࡲࡋࡓࠋ,%%3 ࡣ෌ࡧࡇࡢࡼ࠺࡞ࡇ࡜
ࡀ㉳ࡇࡿ࡜ᡃࡀᅜࡢᅜ㝿ⓗ➇தຊ࡟ࡶᝏᙳ㡪ࢆ୚࠼࠿ࡡ࡞࠸࡜ࡢ༴᝹࠿ࡽࠊឡ▱┴ᒸᓮᕷࡢᇶ♏⏕≀Ꮫ◊✲ᡤࢆ୰᰾ᣐⅬ࡜ࡋ࡚㛤ጞࡉࢀࡓࣉࣟࢪ࢙ࢡࢺ࡛ࡍࠋ ࡉ࡚ࠊᖹᡂ  ᖺ  ᭶  ᪥ࡢ໭ᾏ㐨⫹᣺ᮾ㒊ᆅ㟈࡟ࡼࡾᮏᏛ࡛ࡶ኱つᶍ೵㟁ࡀⓎ⏕ࡋࠊ኱ࡁ࡞⿕ᐖࢆࡶࡓࡽࡋࡲࡋࡓࠋࡇࡢࡼ࠺࡞኱つᶍ⮬↛⅏ᐖ࡟ᑐࡍࡿᏳᐃࡋࡓᩍ⫱◊✲⎔ቃࢆᣢ⥆ⓗ࡟ᥦ౪ࡍࡿࡓࡵࡢᨭ᥼⤌⧊࡜ࡋ࡚ᙜࢭࣥࢱ࣮ࡢ㔜せᛶࡀ෌ㄆ㆑ࡉࢀࠊᮏᖺᗘ࠿ࡽᮏࢭࣥ
ࢱ࣮୧Ჷࡢᨵಟᕤ஦ࡀᐇ᪋ࡉࢀࡿ㐠ࡧ࡜࡞ࡾࡲࡋࡓࠋ᫖ᖺᗘࡲ࡛࡟ᘓ≀ࡢᨵಟィ⏬ࡢ⟇ᐃ࡜ྛ✀ᐇ㦂᪋タ࡜ᐇ㦂⏕≀ࡢ⛣㌿ࡀ⤊஢ࡋࠊ࠸ࡼ࠸ࡼᮏయᘓ≀ࡢᨵಟᕤ஦ࡀጞࡲࡿணᐃ࡛ࡍࠋ ᭱ᚋ࡟࡞ࡾࡲࡋࡓࡀࠊ௧࿴  ᖺᗘ  ᭶ࡼࡾᒣཱྀ῟஧๓ࢭࣥࢱ࣮㛗࡟௦ࢃࡾࠊ⚾ࠊ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ㒊㛛ࡢᑠᕝࡀ᪂ࡓ࡟ࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㛗ࢆᣏ࿨࠸ࡓࡋࡲࡋࡓࠋ
௒ᅇࡢ኱つᶍᨵಟࢆᶵ࡟ᩍ⫱◊✲ࡢඹྠ฼⏝᪋タ࡜ࡋ࡚ࠊࡼࡾ୍ᒙ฼⏝౯್ࡢ㧗࠸ᨭ᥼ࡢᥦ
౪࡟ດࡵ࡚ࡲ࠸ࡾࡲࡍࡢ࡛ࠊ௒ᚋࡶᘬࡁ⥆ࡁࡈ⌮ゎ࡜ࡈ༠ຊࡢ⛬ࠊࡼࢁࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ                 ௧࿴  ᖺ  ᭶                 ኱Ꮫ㝔⌮Ꮫ◊✲㝔                      㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㛗                                   ᑠᕝ ᏹே

目 次

・

２０２１年度概要の発行にあたって・センター教職員・運営委員一覧、令和２年度活動報告

Ｐ １

・

実験生物共同利用部門運営状況

Ｐ ３・

遺伝子実験共同利用部門・動物染色体共同利用部門運営状況

Ｐ ２７

・

添付資料

Ｐ ３７

䝀䝜䝮䝎䜲䝘䝭䜽䝇◊✲䝉䞁䝍䞊䚷ᩍ⫋ဨ䝉䞁䝍䞊㛗䚷
䚷㻌㻌㻌㻌㻌㻌ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛㻌㻌ᩍ䚷㻌ᤵ䚷ᑠᕝ䚷ᏹே㻌㻌෸ᩍᤵ䚷䚷
㻌㻌෸ᩍᤵ䚷䚷
㻌㻌ຓ㻌䚷ᡭ

໭⏣䚷୍༤
ຍ⸨䚷ᚭ
ฟཱྀ䚷ၿ⾜

㑇ఏᏊᐇ㦂ඹྠ฼⏝㒊㛛㻌㻌ᩍ㻌䚷ᤵቑ⏣䚷㝯୍ື≀ᰁⰍయඹྠ฼⏝㒊㛛㻌㻌ຓ㻌䚷ᩍྜྷ⏣䚷㑳ஓ㻌㻌ᢏ⾡ᑓ㛛⫋ဨ㻌㻌◊✲ᨭ᥼᥎㐍ဨ㻌㻌஦ົ⿵ຓဨ

ᑠ㔪䚷ᕸᐇᏊ㻌䠄ᮾᲷ䠅ᑠᆏ䚷䛒䜖䜏㻌䠄すᲷ䠅ᒸᮧ䚷ᰤ⌮䚷㻌㻌䠄すᲷ䠅㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌䝉䞁䝍䞊⫋ဨ㻌㻌䝀䝜䝮䝎䜲䝘䝭䜽䝇◊✲䝉䞁䝍䞊㐠Ⴀጤဨ఍ጤဨ㛗 㻌㻌㻌㻌Ọ஭䚷㝯ဢ䝉䞁䝍䞊㛗䚷㻌㻌㻌㻌ᑠᕝ䚷ᏹே㻌㻌㻌㻌ቑ⏣䚷㝯୍䚷㻌㻌㻌㻌ຍ⸨䚷ᚭ㻌㻌㻌㻌໭⏣䚷୍༤㻌㻌㻌㻌㯮ᒾ䚷㯞㔛㻌㻌㻌㻌ᑠட䚷୍ᘯ䚷䚷⸨⏣䚷▱㐨㻌㻌㻌㻌ᮌᮧ䚷ᩔ㻌㻌㻌㻌㈗ᓥ䚷♸἞㻌㻌㻌㻌ᕝཎ䚷Ꮫᩍ㻌䚷ᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔ᩍ㻌䚷ᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔ᩍ㻌䚷ᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔෸ᩍᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔෸ᩍᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔ᩍ㻌䚷ᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔ᩍ㻌䚷ᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔ᩍ㻌䚷ᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔෸ᩍᤵ㻌㻌㻌㻌㻌㻌⌮Ꮫ◊✲㝔ᩍ㻌䚷ᤵ㻌㻌㻌㻌㻌㻌㎰Ꮫ◊✲㝔෸ᩍᤵ㻌㻌㻌㻌㻌㻌㎰Ꮫ◊✲㝔௧࿴䠎ᖺᗘ㻌㻌άືሗ࿌䞉㻌ᴫせ㻌㻞㻜㻞㻜㻌䠄㻌ᖺḟሗ࿌㻌䠅㻌㻌Ⓨ⾜㻌䠄㻌㻢᭶㻌䠅䞉㻌㐠Ⴀጤဨ఍㛤ദ㻌䠄㻌㻝᭶㻌䠅䞉㻌ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛㻌᪂つ฼⏝⪅ㅮ⩦఍㻌㻌㻌㐲㝸ཬ䜃ᑐ㠃䛻䛶㻢᭶䞉㻝㻜᭶䞉㻝㻝᭶䞉㻝㻞᭶䞉㻞᭶䚷ィ㻝㻝ᅇ㻌㛤ദ

−1−

ᮾᲷ

ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛

−3−

ᐇ 㦂⏕
⏕ ≀ඹ
ඹ ྠ฼⏝㒊㛛ᙜ㒊㛛ࡣࠊ࣐࢘ࢫࠊࣛࢵࢺࠊ࢘ࢧࢠࠊࣔࣝࣔࢵࢺࡢ့ஙື≀࡟ຍ࠼ࠊ࢟ࣥ࢝ࢳࣙ࢘
ࡸ࢘ࢬࣛ➼ࡢ㫽㢮ࠊ࣓ࢲ࢝➼ࡢ㨶㢮ࠊ࢖࢝➼ࡢᾏ⏘ࡢ↓⬨᳝ື≀ࠊࢥ࢜ࣟࢠࡸࢦ࢟ࣈ
ࣜ➼ࡢ᪻⹸ࠊࡲࡓࢩࣟ࢖ࢾࢼࢬࢼ➼ࡢᐇ㦂᳜≀࠿ࡽࠊ㔝እ᥇ྲྀࡉࢀࡓ᳜≀ࠊࡉࡽ࡟ᶞ
ᮌ࡟⮳ࡿࡲ࡛ࠊᵝࠎ࡞⏕≀✀ࢆ㣫⫱࣭᱂ᇵ࡛ࡁࡿࡼ࠺ᩚഛࢆ⾜ࡗ࡚࠸ࡿඹྠ฼⏝᪋タ࡛ࡍࠋ㏆ᖺࡣࠊ࣐࢘ࢫࠊࣛࢵࢺࡢࡳ࡞ࡽࡎࠊࢥ࢜ࣟࢠ࡟࠾࠸࡚ࡶ㑇ఏᏊᨵኚື≀ࡀ㣫㣴ࡉࢀ࡚࠾ࡾࠊἲ࡟‽ᣐࡋࡓ㣫⫱タഛࡢᩚഛ࡟ࡶᚰࡀࡅ࡚࠾ࡾࡲࡍࠋࡇࢀࡽࡢඹྠ฼
⏝࡟ຍ࠼ࠊ࣐࢘ࢫ࡜ࣛࢵࢺࡢ㏆஺⣔ࡢ⥔ᣢ஦ᴗࡶ⾜ࡗ࡚࠾ࡾࡲࡍࠋᮏ᪋タࡢ❹ᕤࡣ᫛࿴  ᖺ࡛࠶ࡾࠊࡍ࡛࡟⠏  ᖺࢆ⤒㐣ࡋ࡚࠾ࡾࡲࡋࡓࠋࡑࡢࡓ
ࡵࠊᨵಟᕤ஦࡟ಀࡿᴫ⟬せồࢆᩥ㒊⛉Ꮫ┬࡟⾜ࡗࡓ࡜ࡇࢁࠊᖾ࠸࡞ࡇ࡜࡟௧࿴  ᖺᗘ࠾ࡼࡧ  ᖺᗘࡢ  ᖺ㛫࡟ࢃࡓࡿண⟬ࢆࡘࡅ࡚࠸ࡓࡔࡃࡇ࡜࡟࡞ࡾࡲࡋࡓࠋᮏᖺᗘ࡟࠾
࠸࡚ࡣࠊ௒ᚋ  ᖺᚋࡢᑗ᮶ࡶ຺᱌ࡋ࡞ࡀࡽࠊᐇ㦂⏕≀ࡢ㣫⫱࣭᱂ᇵࡀࡼࡾ෇⁥࡟ᐇ᪋࡛ࡁࡿࡼ࠺ࠊࡈ᥼ຓ࠸ࡓࡔࡁ࡞ࡀࡽ᪋タࡢタィࢆ᏶஢ࡋࡓ࡜ࡇࢁ࡛ࡍࠋࡇࢀࡶ㛵ಀྛᡤࡢከ኱࡞ࡈຓຊࡀ࠶ࡗࡓ࠿ࡽࡇࡑ࡛࠶ࡾࠊࡈᨭ᥼ࢆ࠸ࡓࡔࡁࡲࡋࡓࡇ࡜࡟ឤㅰ⏦ࡋୖࡆࡲࡍࠋ
᮶ᖺᗘ࠿ࡽࡣࠊ࠸ࡼ࠸ࡼࠊᨵಟᕤ஦ࡀጞࡲࡾࡲࡍࠋᨵಟᕤ஦ࡢᮇ㛫୰࡟ࡣࠊ⌧ᅾ㣫⫱࣭᱂ᇵࡉࢀ࡚࠸ࡿᐇ㦂⏕≀ࡢ௬⛣㌿ࡀᚲ㡲࡜࡞ࡾࡲࡍࠋ௬⛣㌿ᮇ㛫୰ࡶ⁫ࡾ࡞ࡃ◊✲άືࡢᐇ᪋ࡀ⾜࠼ࡿࡼ࠺ࠊࢭࣥࢱ࣮ഃ࡜ࡋ࡚ࡶ᭱኱㝈ࡢᑐᛂ‽ഛࢆ⾜ࡗࡓ࡜ࡇࢁ࡛
ࡍࡀࠊ฼⏝⪅ࡢ᪉ࠎ࡟࠾࠿ࢀࡲࡋ࡚ࡶࠊఱ༞ࠊࡈ༠ຊࢆࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
௒ᚋ࡜ࡶ◊✲⎔ቃࡢྥୖ࡜⥔ᣢࢆ┠ᣦࡋ࡚ࠊ◊✲ཬࡧᐇ㦂ࡢሙࢆᥦ౪ࡋ࡚࠸ࡃດຊ
ࢆ⥆ࡅ࡚ࡲ࠸ࡾࡲࡍࠋ



௧ ࿴㸰
㸰 ᖺ ᗘ  ᐇ 㦂⏕⏕ ≀ඹඹྠ฼⏝㒊㛛 ฼ ⏝≧ἣ ᡤ ᒓ ฼ ⏝⪅ᩘᩘᆅ⌫⎔ቃ⛉Ꮫ◊✲㝔㸱⌮Ꮫ◊✲㝔

㸯㸳

㎰Ꮫ◊✲㝔

㸰ᩍ⫱Ꮫ◊✲㝔㸯ᕤᏛ◊✲㝔

㸰་Ꮫ◊✲㝔

㸯ᩥᏛ◊✲㝔

㸯໭᪉⏕≀ᅪࣇ࢕࣮ࣝࢻ⛉Ꮫࢭࣥࢱ࣮

㸯⥲ྜ༤≀㤋

㸯

ィ

㸰 㸵

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−4−

௧࿴䠎ᖺᗘ฼⏝⪅䛾ෆヂ༤≀㤋㻘㻌㻝
ᾏỈ㻘㻌㻡໭᪉䢈䡤䡬䢕䢀䢚㻘㻌㻝့ங㢮䞉㫽㢮㻘㻌㻥

ᩥ㻘㻌㻝
ᩍ⫱㻘㻌㻝

⣧Ỉ㻘㻌㻠

་㻘㻌㻝

⌮㻘㻌㻝㻡

ᕤ㻘㻌㻞
Ỉ⏕ື≀㻘㻌㻝
㎰㻘㻌㻞฼⏝⏦ㄳ⪅ᡤᒓ㒊ᒁ

38

H25

᪻⹸㻘㻌㻠

᳜≀㻘㻌㻠

ᆅ⌫⎔ቃ㻘㻌㻟

ᢅ䛳䛶䛔䜛⏕≀ཬ䜃Ỉ➼฼⏝䛾⏦ㄳᩘ

41
36

H26

H27

34

H28

30

31

H29

H30

31
27

R1

R2

฼⏝⏦ㄳᩘ᥎⛣⣔⤫ಖᏑ䝸䝇䝖
䝬䜴䝇䠄㻤⣔⤫䠅⣔⤫ྡ౪⤥ᩘ䝷䝑䝖䠄㻝㻝⣔⤫䠅౪⤥ඛ⣔⤫ྡ㻮㻭㻸㻮㻛㼏

㻭㻯㻵㻮㻭㻸㻮㻛㼏㻭㼚

㻭㻯㻵㻔㻿㻕

㻮㻷㻴

㻭㻸㻮

㻯㻮㻭

㻮㻺

㻯㻮㻭㻛㻴㻙㼀㻢

㻷㼅㻺㻯㻡㻣㻮㻸㻛㻢

㻸㻱㻭

㻯㻟㻴

㻸㻱㻶

㻸㼀㻛㻿㼢

㻺㻵㻳㻙䊢

౪⤥ᩘ

౪⤥ඛ

䗠㻞㻞㻘㻌䗢㻝㻟

ி㒔኱Ꮫ䞉㻺㻮㻾㻼䛂䝷䝑䝖䛃

㻿㻰㻶
㼀㻻
㼃㻷㻭㻴

−5−

䚷

௧࿴䠎ᖺᗘ㻌ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛䚷ಖᏲႠ⧋䝸䝇䝖

௧࿴㻞ᖺ

௧࿴㻟ᖺ

㻠᭶

ᐃᮇΎᤲ㻔ẖ᭶䠅⎔ቃ⾨⏕⟶⌮Ⅼ᳨䠄ẖ᭶䠅ᶞᮌ෤ᅖ䛔እ䛧ᴗົ㻤᭶㻝㝵Ὑίᐊᾘẘჾᛶ⬟᳨ᰝᩚഛ䠄䜸䞊䝖䜽䝺䞊䝤䠅㠀ᖖ⏝Ⓨ㟁ᶵ⡆᫆Ⅼ᳨㻝㻜᭶㻝㝵䛢䛳ṑ㢮ᐊ㻼㻭㻯㻙㻝 Ỉ䝁䜲䝹ಟ⌮ᶞᮌ෤ᅖ䛔ᴗົ

㻝㻝᭶㻝㝵䛢䛳ṑ㢮ᐊ㻼㻭㻯㻙㻞 Ỉ䝁䜲䝹ಟ⌮㻝᭶㻝㝵䛢䛳ṑ㢮ᐊ㻼㻭㻯㻙㻝 Ỉ䝁䜲䝹ಟ⌮㻝㝵 ᐊ䝟䝛䝹䝠䞊䝍䞊⣔⤫ Ỉ㓄⟶ಟ⌮㻞㝵㻾㻙㻝⣔⤫䜶䜰䝁䞁ᐊእᶵಟ⌮−6−௧࿴䠎ᖺᗘ䚷䝀䝜䝮䝎䜲䝘䝭䜽䝇◊✲䝉䞁䝍䞊䚷฼⏝⪅◊✲ㄢ㢟䠄ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛䠅ᡤ㻌㻌ᒓ㒊㻌㻌㛛㻌㻌䞉㻌㻌ศ㻌㻌㔝㻌㻌㻌➼⫋㻌ྡᆅ⌫⎔ቃ⛉Ꮫ
◊✲㝔ᆅ⌫⎔ቃ⛉Ꮫ
◊✲㝔ᆅ⌫⎔ቃ⛉Ꮫ
◊✲㝔⤫ྜ⎔ቃ⛉Ꮫ䞉⮬↛⎔ቃಖ඲ᩍ㻌ᤵ㟢ᓮ㻌㻌ྐᮁ 䚷ⅆᒣ䛻䛚䛡䜛ᇙᅵ✀Ꮚ㞟ᅋ䛾ᐃ㔞䛚䜘䜃⏕⫱ᐇ㦂⤫ྜ⎔ቃ⛉Ꮫ䞉⎔ቃ㐺ᛂ⛉Ꮫᩍ㻌ᤵἈ㔝㻌㻌㱟ᩥ 䚷ᾏ⏘⸴㢮䛾஧ḟ௦ㅰ⏘≀䛻㛵䛩䜛◊✲⎔ቃ⏕≀⛉Ꮫ䞉㝣ᇦ⏕ែᏛ

෸ᩍᤵ

ᕤ⸨䚷ᓅ

⌮Ꮫ◊✲㝔

≀⌮Ꮫ䞉㔞Ꮚ≀⌮Ꮫ෸ᩍᤵᯇỌ㻌㻌ᝅ᫂ 䚷᭷ᶵᑟయ䛻䛚䛡䜛≀ᛶ⌮Ꮫ◊✲㝔≀⌮Ꮫ䞉㟁Ꮚ≀ᛶ≀⌮Ꮫᩍ㻌ᤵἙᮏ㻌㻌඘ྖ 䚷ศᏊᛶᑟయ䛾ྜᡂ⌮Ꮫ◊✲㝔ᆅ⌫ᝨᫍ⛉Ꮫ䞉Ᏹᐂᝨᫍ⛉Ꮫᩍ㻌ᤵ㧗ᶫ䚷ᖾᘯ 䚷᳜≀䛾㻮㻾㻰㻲⮬ືィ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉ᙧែᶵ⬟Ꮫ෸ᩍᤵబ⸨䚷㛗⥴ 䚷㧗➼᳜≀䛾ᶵ⬟Ⓨ⌧䞉⎔ቃᛂ⟅ไᚚᶵᵓ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫᩍ㻌ᤵᑠᕝ㻌㻌ᏹே 䚷䝣䝍䝩䝅䝁䜸䝻䜼䛾⚄⤒⾜ືᏛⓗ◊✲⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ

ᩍ㻌ᤵ

ỈἼ㻌㻌ㄔ

⌮Ꮫ◊✲㝔

⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ෸ᩍᤵ໭⏣㻌㻌୍༤ 䚷᪂䛯䛺⑓ែ䝰䝕䝹ື≀䛾సฟ䛸ཎᅉ㑇ఏᏊ䛾ྠᐃ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ෸ᩍᤵ࿴ከ㻌㻌࿴ᏹ 䚷㬆⚺㢮䜢⏝䛔䛯ⓎኌᏛ⩦䞉⏕ᡂ䛸䛭䛾⬻ෆศᏊᶵᵓ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫᩍ㻌ᤵ㯮ᒾ䚷㯞㔛 㻌㻌့ங㢮䛚䜘䜃㫽㢮䛻䛚䛡䜛ᛶỴᐃ䞉ཷ⢭䛻㛵䜟䜛ศᏊ䝯䜹䝙䝈䝮䛾ゎ᫂⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ෸ᩍᤵⲶཎ㻌㻌ඞ┈ 䚷⬨᳝ື≀䛾⏕Ṫᶵ⬟䛻㛵䛩䜛◊✲⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ

෸ᩍᤵ

ᮌᮧ㻌㻌ᩔ

⌮Ꮫ◊✲㝔

⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ෸ᩍᤵᑠ㇂㻌㻌཭ஓ 䚷༸ẕ⣽⬊ᙧᡂ䛸ึᮇⓎ⏕䛾ศᏊᶵᵓゎᯒ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉ከᵝᛶ⏕≀Ꮫᩍ㻌ᤵᑠட㻌㻌୍ᘯ 䚷⸴㢮䛾⣔⤫㐍໬Ꮫ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉ከᵝᛶ⏕≀Ꮫ

෸ᩍᤵ

᯳ཎ㻌㻌ᏹ

䚷ᾏ⏘↓⬨᳝ື≀䛾⣔⤫ศ㢮Ꮫⓗ◊✲⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉ከᵝᛶ⏕≀Ꮫ

෸ᩍᤵ

ຍ⸨㻌㻌ᚭ

䚷䝅䝵䜴䝆䝵䜴䝞䜶䛚䜘䜃᳜㣗ᛶ䝔䞁䝖䜴䛾㐍໬Ꮫⓗ◊✲㎰Ꮫ◊✲㝔ᇶ┙◊✲䞉⏕≀㈨※⛉Ꮫᩍ㻌ᤵ⛅ඖ㻌㻌ಙ୍ 䚷䝃䝑䝫䝻䝣䜻䝞䝑䝍䛾㓄അ⾜ື䛸⏕Ṫ㝸㞳ᶵᵓ䛻㛵䛩䜛◊✲㎰Ꮫ◊✲㝔ᇶ┙◊✲䞉␆⏘⛉Ꮫ

෸ᩍᤵ

ᕝཎ㻌㻌Ꮫ

ᩍ⫱Ꮫ◊✲㝔

ᩍ⫱Ꮫ䞉೺ᗣయ⫱Ꮫ෸ᩍᤵ ᒣ௰䚷ຬ஧㑻 䚷㻌⏕≀᫬ィ䛻䜘䜛⾜ື䝸䝈䝮䛾ᨭ㓄ᵝᘧ䛸⾜ື䝸䝈䝮䛛䜙୰ᯡ᫬ィ䜈䛾䝣䜱䞊䝗䝞䝑䜽ᶵᵓ䛾ゎ᫂ᕤᏛ◊✲㝔ᛂ⏝≀⌮Ꮫ䞉㔞Ꮚ≀ᛶᕤᏛ

ᩍ㻌ᤵ

୹⏣㻌㻌⪽

䚷పḟඖᑟయ䛾㟁Ꮚ≧ែ䛾◊✲ᕤᏛ◊✲㝔ᶵᲔ䞉Ᏹᐂ⯟✵ᕤᏛ䞉⇕ὶయ䡸䡹䡿䢍

ᩍ㻌ᤵ

⏣㒊䚷㇏

䚷⇞ᩱ㟁ụෆỈศᣲືཬ䜃෾⤖⌧㇟䛾ྍど໬ほᐹ་Ꮫ◊✲㝔་ṑᏛ⥲ྜ◊✲Ჷ䞉୰ኸ◊✲㒊㛛ຓ㻌ᩍᒣ㔝㎶㻌㈗ಙ 㻌㻌⚄⤒⣔䛻䛚䛡䜛᝟ሗ䜻䝱䝸䜰䜢᫂䜙䛛䛻䛩䜛ᩥᏛ◊✲㝔ே㛫⛉Ꮫ䞉ᚰ⌮Ꮫᩍ㻌ᤵ࿴⏣㻌㻌༤⨾ 䚷䝷䝑䝖䛾㉸㡢ἼⓎኌ䛻ཬ䜌䛩Ỉ㓟໬㻼㻯㻮ཬ䜃㻼㻮㻰㻱䛾ᙳ㡪෸ᩍᤵᅄ䝒಴㻌඾⁠ 䚷䝁䞁䝤㢮䛻䛴䛔䛶䚸ᇵ㣴ಖᏑἲ䛾☜❧䛸✀ⱑసฟᢏ⾡䛾㛤Ⓨ෸ᩍᤵ㜿㒊㻌㻌๛ྐ 䚷⣚⸴䝋䝌ᒓ䛚䜘䜃㏆⦕ᒓ䛻㛵䛩䜛✀⏕≀Ꮫⓗ◊✲໭᪉⏕≀ᅪ䝣䜱䞊
⏕≀ከᵝᛶ㡿ᇦ䞉ᾏ⏘⸴㢮㐺ᛂᶵ⬟䝹䝗⛉Ꮫ䝉䞁䝍䞊

⥲ྜ༤≀㤋◊✲㒊䞉㈨ᩱᇶ♏◊✲⣔Ặ㻌㻌ྡ◊㻌㻌✲㻌㻌ㄢ㻌㻌㢟㻌㻌ྡ䚷䝬䝒䝶䜲䜾䝃ᒓ᳜≀䛾㏦⢊⏕ែᏛ䛻㛵䛩䜛◊✲ᐃ䝅䝇䝔䝮䛾◊✲㛤Ⓨ䚷᪻⹸䛾Ꮫ⩦䛾⚄⤒ᶵᵓ䚷့ங㢮䛾⏕Ṫ䛻䛛䛛䜟䜛䝀䝜䝮ᶵ⬟䛻㛵䛩䜛◊✲䚷䝬䜴䝇⬇యእ᧯స䛻䜘䜛ಶయⓎ⏕䛻㛵䛩䜛◊✲−7−Мဇ‫إ‬ԓᴾᴾ
኱Ꮫ㝔ᆅ
ᆅ⌫⎔
⎔ቃ⛉Ꮫ◊
◊✲㝔
㝔
⤫ྜ⎔
⎔ቃ⛉
⛉Ꮫ㒊㛛
 ⮬↛⎔ቃಖ඲ศ㔝㟢ᓮ ྐᮁ฼⏝⪅: ⠊ ⍞⌈࣭ᱵᮧᫀᏹ
ࢭࣥࢱ࣮ᮾᲷ ᐊ࡟࠾࠸࡚ࠊ(1)ⅆᒣ㑄⛣ึᮇẁ㝵࡟࠾ࡅࡿᇙᅵ✀Ꮚ⤌ᡂ࡜᳜⏕㛫ࡢẚ㍑࡜ࠊ(2)࣡
ࢱࢫࢤᐇ⏕ᡂ⫱࡜㇂ᆅᆓ୺ᙧᡂ㐣⛬࡟㛵ࡍࡿᐇ㦂ࢆࠊ௨ୗࡢ㏻ࡾ⾜ࡗࡓࠋ(1) ⅆᒣ㑄⛣ึᮇẁ㝵࡟࠾ࡅࡿᇙᅵ✀Ꮚ⤌ᡂ࡜᳜⏕㛫ࡢẚ㍑ⅆᒣᄇⅆ࡟௦⾲ࡉࢀࡿ኱つᶍ᧠஘ᚋࡢ㑄⛣ึᮇẁ㝵࡟ࡣࠊ᳜⏕ᙧᡂ࡟ࡘࢀᇙᅵ✀Ꮚ㞟ᅋࡶⓎ㐩ࡍࡿࠋࡋ࠿ࡋࠊ㑄⛣ึᮇ࡟ࡣࠊእ᮶᳜≀ࡢ౵ධᐃ╔ࡀ㢧ⴭ࡟ㄆࡵࡽࢀࡿࡇ࡜ࡀ࠶ࡾࠊ㑄⛣ࡀᴟ┦࡟ྥ࠿ࢃ࡞࠸೫ྥ㑄⛣࡜࡞ࡿࡇ࡜ࡶ࠶ࡿࠋࡑࡢせᅉࡢ୍ࡘ࡜ࡋ࡚ࠊእ᮶✀ࡢᇙᅵ✀Ꮚ㞟ᅋࡢⓎ㐩ࡀᙳ㡪ࡋ࡚࠸ࡿࡇ࡜ࡀ⪃࠼ࡽࢀࡿࠋࡑࡇ࡛ࠊᇙᅵ✀Ꮚ⤌ᡂࢆᐃ㔞໬ࡋࠊᇙᅵ✀Ꮚ㞟ᅋ࡜⌧Ꮡ᳜⏕࡜ࡢ㛵㐃ᛶࢆㄪ࡭ࡿࡓࡵ࡟ࠊ᭷⌔ᒣࡢ 2000 ᖺᄇⅆ㊧ᆅ(すᒣⅆཱྀ⩌)࠿ࡽᄇⅆ㝆⅊≀(ࢸࣇࣛ)ࢆ᥇ྲྀࡋࠊ ᐊ࡟࠾࠸࡚ࠊⓎⱆᐇ㦂ࢆ⾜࠸ᇙᅵ✀Ꮚ㞟ᅋࢆᐃ㔞ⓗ࡟ ᐃࡋࡓࠋ
2020 ᖺࡢ᫓(6 ᭶)࠾ࡼࡧ⛅(10 ᭶)࡟ࠊすᒣⅆཱྀ⩌ෆࡢప᳜⿕ᆅᇦ࠾࠸࡚ࠊẖᅇࠊ112 ಶࡢࢸࣇࣛࢧࣥ
ࣉࣝࢆࠊᐜ㔞ࡀ 100 cm3 ࡢ᥇ᅵ⟶(῝ࡉ 5 cm)ࢆ⏝࠸࡚᥇ྲྀࡋࡓࠋ᥇ྲྀࣧᡤࡣࠊ〄ᆅࠊᅾ᮶✀ࡢࢫࢫ࢟ࡀඃ༨ࡍࡿ᳜⏕ࠊእ᮶✀ࡢࣘ࢘ࢮࣥࢠࢡ࠶ࡿ࠸ࡣ
ࣈࢱࢼࡀඃ༨ࡍࡿ᳜⏕࡛࠶ࡿࠋ᥇ྲྀࢧࣥࣉࣝࡣ 2㐌㛫࡯࡝ప ‵ᒙฎ⌮ࢆ᪋ࡋࠊཌࡉ 5 mm ௨ୗ࡟ࡋ࡚ࣂ࣮࣑࢟ࣗࣛ࢖ࢺࢆᩜ࠸ࡓࢺࣞ࢖(16 cm × 23cm, ῝ࡉ 6.5 cm)ୖ࡟ᧈࡁฟࡋࡓࠋ ᐊ࡟࠾ࡅࡿ᫓
ࢧࣥࣉࣝࡢⓎⱆᐇ㦂ࡣ 7 ᭶ 15 ᪥࡟ࠊ⛅ࢧࣥࣉࣝࡢ
ᐇ㦂ࡣ 11 ᭶ 1 ᪥࡟㛤ጞࡋࡓࠋᩓỈࡣࠊ⮬ືࢫࣉࣜࣥࢡ࣮࡛ࣛ 1 ᪥ 7 ᅇ⾜ࡗࡓࠋⓎⱆほᐹࡣࠊྍ⬟࡞㝈ࡾẖ᪥⾜࠸ࠊⓎⱆᐇ⏕ࢆグ㘓ࡋࡓࠋほᐹࡣࠊ᫓࣭
⛅ࢧࣥࣉࣝ࡜ࡶ࡟ 4 ࠿᭶⛬ᗘ⾜ࡗࡓ(⛅ࢧࣥࣉࣝࡣ
ᐇ㦂⥅⥆୰)ࠋⓎⱆࡋࡓᐇ⏕࡟ࡘ࠸࡚ࡣࠊ✀ྠᐃࡀ࡛ࡁḟ➨ࠊࢺࣞ࢖࠿ࡽ㝖ཤࡋࡓࠋ᫓ࢧࣥࣉࣝ࠿ࡽ
ࡣࠊ2109 ಶయࡢᐇ⏕ࡀ 18 ✀࠿ࡽᚓࡽࢀࡓࠋ⛅ࢧࣥࣉࣝ࠿ࡽࡣࠊ978 ಶయࡢᐇ⏕ࡀ 6 ✀࠿ࡽᚓࡽࢀ
ࡓࠋ᫓࣭⛅࠸ࡎࢀࡢࢧࣥࣉࣝ࡟࠾࠸࡚ࡶ᳜⏕ࢆၥࢃࡎࠊᅾ᮶✀࡛࠶ࡿࣁࣁࢥࢢࢧࡀඃ༨ࡋࠊࡘ࠸࡛
ᅾ᮶✀࡛࠶ࡿ࢚ࢰࢾ࢝࣎ࠊ࣓ࣄࢩࣂࡀከࡃㄆࡵࡽ
ࢀࡓࠋ୍᪉ࠊእ᮶✀࡛᳜⏕୰࡟ඃ༨ࡍࡿࣘ࢘ࢮࣥ
ࢠࢡࠊࣈࢱࢼࡢᇙᅵ✀Ꮚࡣஈࡋ࠿ࡗࡓࠋࡇࢀࡽࡢ
⤖ᯝࡣࠊእ᮶✀ࡢ౵ධᐃ╔ࡀᇙᅵ✀Ꮚ㞟ᅋࡢⓎ㐩ࢆ௓ࡉࡎ࡟㉳ࡇࡗ࡚࠸ࡿࡇ࡜ࢆ♧၀ࡋ࡚࠸ࡿࠋ௒

ᚋࠊࡇࢀࡽࡢ⤖ᯝ࡜㔝እㄪᰝ⤖ᯝࢆྜࢃࡏࠊ᳜⏕ᇙᅵ✀Ꮚ㛵ಀࢆゎᯒࡍࡿணᐃ࡛࠶ࡿࠋ࡞࠾ࠊࣁࣁ
ࢥࢢࢧࡣࠊㄪᰝ༊ᇦෆ࡛ࡣࠊ࡯࡜ࢇ࡝ᐃ╔ࡀㄆࡵࡽࢀ࡚࠾ࡽࡎࠊᮏ✀࡟࠾ࡅࡿᇙᅵ✀Ꮚ㞟ᅋࡢᶵ⬟࡟㛵ࡍࡿ⯆࿡࠶ࡿㄢ㢟ࡀᥦ♧ࡉࢀࡓࠋ(2) ࣡ࢱࢫࢤᐇ⏕ᡂ⫱࡜㇂ᆅᆓ୺ᙧᡂ㐣⛬㇂ᆅᆓ୺ᙧᡂ࡟ࡣ ᗘࡸ㝆Ỉ㔞ࠊᅵተ❅⣲(N)㔞
➼ࡀ㛵୚ࡍࡿ࡜࠸࠺௬ㄝࡀ࠶ࡿࡀࠊ᳨ドࡣ࡞ࡉࢀ࡚࠸࡞࠸ࠋࡑࡇ࡛ࠊ࣡ࢱࢫࢤ(Eriophorum vaginatumL.)ᐇ⏕ࢆ⏝࠸࡚ࠊ㇂ᆅᆓ୺ᙧᡂࡢึᮇẁ㝵ࢆ෌⌧ࡍࡿࡇ࡜ࢆ┠ⓗ࡟ࠊ ᐊ࡟࠾࠸࡚ᶍೌᐇ㦂ࢆ 2019ᖺ⛅࡟㛤ጞࡋ 2020 ᖺ 7 ᭶ࡲ࡛⾜ࡗࡓࠋ᪉ἲ࠾ࡼࡧ
2019 ᖺᗘᡂᯝࡣ๓ሗ(2020 ᖺᖺḟሗ࿌)࡟グࡋࡓ㏻ࡾ࡛࠶ࡿࠋᐇ㦂ᴫせࡣ௨ୗࡢ㏻ࡾࠋࣉࣛࣥࢱ࣮(18cm × 58 cm × 15 cm)ෆ࡟⛣᳜ࡋࡓᐇ⏕࡟ᑐࡋ࡚ࠊ᪋
⫧࣭┒ᅵฎ⌮ࠊ᪋⫧ฎ⌮ࠊ┒ᅵฎ⌮ࠊ↓ฎ⌮(ᑐ↷)ࡢ࠸ࡎࢀ࠿ࡢฎ⌮ࢆ᪋ࡋ࡚ᡂ⫱ᐇ㦂ࢆ⾜ࡗࡓࠋ᪋⫧࣭┒ᅵࡣ᭱ึࡢ 2 ࠿᭶ࡣ㐌࡟ 1 ᗘࠊࡑࢀ௨㝆ࡣ
᭶࡟ 1 ᗘ⛬ᗘ⾜࠸ࠊࡑࡢ㒔ᗘࠊᐇ⏕ࡢⴥࡢ᭱኱㛗࣭ᯛᩘࢆィ ࡋࡓࠋࡇࢀࡽࡢᐇ⏕ࡣࠊ2020 ᖺ 7 ᭶࡟ᅇ཰ࡋࣂ࢖࣐࢜ࢫࢆ ᐃࡋࡓࠋࢧࣟ࣋ࢶ‵ཎἾⅣ
᥇᥀㊧ᆅ࡟ࠊᙜ ᐊ࡛ᡂ⫱ࡉࡏࡓᐇ⏕ࢆ⛣᳜ࡋࠊࡑࢀࡽࢆ ᐊ࡟࠾ࡅࡿᐇ⏕ᡂ⫱࡜ẚ㍑ࡋࡓࠋᐇ⏕ࡢⴥ᭱኱㛗࣭ᯛᩘ࡜ࡶ࡟ࠊ ᐊࡢ᪉ࡀ㔝እࡼࡾࡶ㧗࠸್ࢆ♧ࡋࡓࠋ᪋⫧࡟ࡼࡾᆅୖ㒊ࠊᆅୗ㒊୧᪉࡛ࣂ࢖࣐࢜ࢫࡀ኱ࡁ࠿ࡗࡓࠋࡋ࠿ࡋ࡞ࡀࡽࠊ┒ᅵ࡟ࡼࡿࣂ࢖࣐࢜ࢫࡢኚ໬ࡣ᳨ฟࡉࢀࡎࠊἾⅣሁ✚࡟ࡼࡿ㇂ෆᆓ୺ࡢᙧᡂࡢྍ⬟ᛶࡣప࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓࠋㄽᩥVégh, L, & Tsuyuzaki, S. (in press) Comparison ofvegetation patch dynamics after the eruptions of the
volcano Mount Usu, northern Japan, in 1977-78 and
2000, detected by imagery chronosequence. EcologicalResearch
Hoyo, Y., Hoshino, Y. & Tsuyuzaki, S. 2020. Formationand establishment of neopolyploids from sterile
hybrids in Drosera in a disturbed environment. Folia
Geobotanica 55: 185–193
Shishir, S., Mollah, T.H., Tsuyuzaki, S. & Wada, N. 2020.
Predicting the probable impact of climate change on
the distribution of the threatened Shorea robusta forest.
Global Ecology and Conservation 24, e01250
Tsuyuzaki, S. 2020. The seed germination ofberry-producing ericaceous shrubs in relation todispersal by hare. Botany Letters 167: 424-429
Tsuyuzaki, S. & Zhang, X. 2020. Frond size, shape andfertility of Thelypteris confluens (Thunb.) C. V.
Morton in wetlands disturbed by human activities in
Hokkaido, northern Japan. Flora, 151630

−8−

Ꮫ఍Ⓨ⾲
Végh L, Tsuyuzaki S. 2021. The effects of different
forest types on soil characteristics after 40 and 110
years of volcanic eruptions on Mount Usu, Japan.
➨ 77 ᅇ᪥ᮏ⏕ែᏛ఍ (ᒸᒣ, ࣏ࢫࢱ࣮)Ꮡࡋࡓࡀࠊಶయࡢ⥲ⰼ⏕⏘ᩘࡣಶయࡢ㛤ⰼࢧ࢖ࢬ࡟౫Ꮡࡋ࡞࠿ࡗࡓࠋࡉࡽ࡟ࠊ㛤ⰼࣇ࢙ࣀࣟࢪ࣮ࡣ
㧗⦋ᗘᆅᇦ࡛᪩ࡲࡿഴྥ࡟࠶ࡾࠊ୍᪥ࡢ୰ࡢⰼࡢ
㛤ⰼ㛤ጞ᫬㛫ࡶ㧗⦋ᗘᆅᇦ࡛᪩࠸ࡇ࡜ࡀ᫂ࡽ࠿࡟
࡞ࡗࡓࠋ௒ᖺᗘࡣࠊ2018 ᖺ࡟▼⊁ᕷࡣࡲ࡞ࡍࡢୣබᅬ࡛ ⎔ቃ㐺ᛂ⛉Ꮫศ㔝⤫ྜ⎔ቃ⛉Ꮫ㒊㛛᥇ྲྀࡋࡓ✀Ꮚ࠿ࡽసᡂࡋࡓேᕤಶయ⩌࡜ࠊୖグࡢἈ㔝 㱟ᩥ㸦ᾏỈ฼⏝㸧
3 ࠿ᡤࡢẚ㍑᳨ドࢆ⾜ࡗࡓࠋ(1) ⰼ࠾ࡼࡧ᳜≀ಶయࡢᙧែⓗ≉ᚩࡢẚ㍑
ㄽᩥⓎ⾲
㔝እಶయ⩌࡟࠾ࡅࡿ᳜≀ಶయࡢⰼࡢ኱ࡁࡉࠊ᳜≀Mehjabin, J. J., Liang, W., Petitbois, J. G., Umezawa, T.,㧗࡟ࡘ࠸࡚ࡣ๓ᖺࡢ 2019 ᖺ࡜኱ࡁࡃഴྥࡣኚࢃ
Matsuda, F., Vairappan, C. S., Morikawa, M. and Okino,ࡽ࡞࠿ࡗࡓࠋ୍᪉࡛㛤ⰼಶయࡢᆅ㝿┤ᚄ࡟ࡘ࠸࡚
T. (2020) Biosurfactants from marine cyanobacteriaࡣ㫽ྲྀ┴⡿Ꮚᕷࡢࡳ 2020 ᖺࡀ 2019 ᖺ࡟ẚ࡭࡚ඃ
collected in Sabah, Malaysia. Journal of Natural఩࡟኱ࡁ࠸ࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ
Products 83: 1925-1930.
(2) 㛤ⰼࣇ࢙ࣀࣟࢪ࣮࡜㛤ⰼ᫬㛫ࡢ ᐃ᫖ᖺࡢ◊✲࠿ࡽࠊ㔝እಶయ⩌ 3 ᆅⅬ࡜ᮐᖠಶయ⩌ 㝣⏕⏕ែᏛศ
ศ㔝⎔ቃ⏕≀⛉Ꮫ㒊㛛࡟࠾࠸࡚ࠊྛಶయࡀ࠸ࡘ᭱ึࡢⰼࢆဏ࠿ࡏࡿ࠿ࢆ
ᕤ⸨ ᓅ
グ㘓ࡋࡓ࡜ࡇࢁ㛤ⰼࣇ࢙ࣀࣟࢪ࣮ࡣ㧗⦋ᗘᆅᇦ࡛
◊✲ᚑ஦⪅: ኱ᔱᕼ⨾᪩ࡲࡿഴྥ࡟࠶ࡾࠊ୍᪥ࡢ୰ࡢⰼࡢ㛤ⰼ㛤ጞ᫬㛫ࡶ㧗⦋ᗘᆅᇦ࡛᪩࠸ࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋࡲࡓࠊ
฼⏝≧ἣ࣭◊✲ᡂᯝ㛤ⰼ᫬㛫࡟ࡘ࠸࡚ࡣᮐᖠ࡟࠾࠸࡚ᐃⅬ࣓࢝ࣛࢆタື≀፹ࡢ᳜≀ࡢሙྜࠊⰼࡢᙧែࡣື≀ࡢㄏᘬຠ⨨ࡋࠊ7 ᭶ 1 ᪥࠿ࡽ 10 ᭶ 28 ᪥ࡲ࡛ࡢྛ㐌࡛ⰼࡢ⋡࡟㛵ࢃࡿࠋ౛࠼ࡤࠊⰼࡢⰍ࡟ࡼࡗ࡚࡝ࡢ᪻⹸ࡀ
㛤ⰼ᫬㛫ࢆ ᐃࡋࡓࠋࡇࡢ㛤ⰼ᫬㛫ࢆㄝ᫂ኚᩘࠊ
ㄏᘬࡉࢀࡿ࠿ࡀ㐪ࡗ࡚ࡃࡿ࡜࠸ࡗࡓ౛ࡀ࠶ࡿࠋࡇ
㐌ࢆᛂ⟅ኚᩘࠊࣛࣥࢲ࣒ຠᯝࢆಶయ ID ࡜ࡋ࡚⥺ᙧࡢ࠺ࡕࠊⰼࡢ㤶ࡾࡸ⻤ࡣ࣏ࣜࢿ࣮ࢱ࣮ࢆㄏᘬࡍࡿ
ᅇᖐࢆ⾜࠸ࠊࡇࡢᅇᖐ⥺࡜ྛㄪᰝᆅⅬ࡜ࡢࡎࢀࢆ
୺࡞ಙྕࡢ୍ࡘ࡛࠶ࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿ
ᐃࡋࡓࠋࡇࡢ⤖ᯝࠊ▼⊁ࡣᮐᖠ࡜኱ࡁࡃኚࢃࡽ
(Legenheum 1994)ࠋᮏ◊✲࡛ᑐ㇟࡜ࡍࡿ࣐ࢶࣚ࢖ࢢ
࡞࠿ࡗࡓࡀࠊ᪥❧ࡣᮐᖠࡼࡾࡶ㐜ࡃ㛤ⰼࡋ࡚࠸ࡿ
ࢧᒓ᳜≀ࡣᇶᮏⓗ࡟ኪဏࡁࡢ᳜≀࡛࠶ࡿࠋࡇࢀࡲ
࡛ࠊ࣐ࢶࣚ࢖ࢢࢧᒓ࡟ࡘ࠸࡚ࡢඛ⾜◊✲࡟࠾࠸࡚ࠊ ഴྥ࡟࠶ࡾࠊ⡿Ꮚࡶྠᵝ࡛࠶ࡗࡓࠋ
ࡇࡢഴྥࡣ⤒ᖺࢆኚ໬ࡋ࡚ࡶ㔝እ࡟࠾࠸࡚ኚ໬ࡣ
࣏࣮ࣛࣥࢻࡢ࣐ࢶࣚ࢖ࢢࢧ᳜≀ 5 ✀࡟ࡘ࠸࡚ࠊ᫨
ぢࡽࢀ࡞࠿ࡗࡓࠋ⛣᳜ಶయ⩌࡟࠾࠸࡚ࡣࠊⲈᇛ┴ኪ㛫࡛ⰼ⻤୰ࡢ⢾ศ㔞ࡢኚ໬࡜ࠊ᫨ኪ㛫࡛ࡢ࣏ࣜࡦࡓࡕ࡞࠿ᕷ⏤᮶ࡢࡶࡢࠊ㫽ྲྀ┴⡿Ꮚᕷ⏤᮶ࡢࡶࢿ࣮ࢱ࣮ኚ໬᫨㛫ࡣ⭷⩟┠ࠊኪ㛫ࡣ㫣⩟┠)ࡀほᐹࡢࡶ⏕⫱୙Ⰻࡔࡗࡓࡓࡵ㛤ⰼ᫬㛫ࡢᐇ㦂ᅡሙ࡛ࡢࡉࢀࡓࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿ(Anton et al. 2017)ࠋࡲ
ィ ࡣ࡛ࡁ࡞࠿ࡗࡓࠋࡇࡢࡇ࡜࠿ࡽୖグࡢഴྥࡣࡓࠊ㏦⢊⪅ࡢ⩚㡢࡟ࡼࡗ࡚⻤ࡢศἪࢆ⾜࠺ࡇ࡜ࡀ㑇ఏⓗ࡞ࡶࡢ࡞ࡢ࠿ࠊ⎔ቃⓗ࡞ࡶࡢ࡞ࡢ࠿࡟ࡘ࠸
ሗ࿌ࡉࢀ࡚࠸ࡿ (Veits et al. 2019)ࠋ࣐ࢶࣚ࢖ࢢࢧᒓ࡚ࡢ᳨ドࡣ୙༑ศ࡛࠶ࡿࠋ
᳜≀ࡢ࠺ࡕ࣓࣐ࢶࣚ࢖ࢢࢧ ࡣࠊ஧ᖺⲡࠊ⮬ᐙ࿴ྜ௨ୖࡢ⤖ᯝ࠿ࡽࠊẼ㇟᮲௳࠿ࡽࠊࡲࡎྛᆅࡢᙧ
ᛶࡢ୍᪥ⰼࢆࡘࡅࡿ᳜≀࡛࠶ࡿࠋࡇࡢ✀࡟࠾࠸࡚ࡣࠊኪ㛫ࡢ࣏ࣜࢿ࣮ࢱ࣮࡟ࡘ࠸࡚ࡢሗ࿌౛ࡣከ࠸ࠋ ែⓗ࡞≉ᚩࡣ㢼ຊ࡞࡝ࡢẼ㇟᮲௳࡟ᛂࡌ࡚ኚ໬ࡋ
࡚࠸ࡿ࡜⪃࠼ࡽ࠼ࡿࠋࡲࡓࠊ㧗⦋ᗘᆅᇦ࡛ࡣᡂ㛗ࡋ࠿ࡋࠊࡇࡢ✀ࡀࡘࡅࡿ୍᪥ⰼࡣ᫨ࡈࢁࡲ࡛ࡣဏ
ྍ⬟࡞᫬㛫ࡀ▷࠸ࡓࡵࠊ㛤ⰼࣇ࢙ࣀࣟࢪ࣮ࡀ๓ಽ
࠸࡚࠾ࡾࠊ࣓࢖ࣥࡢ࣏ࣜࢿ࣮ࢱ࣮ࡀ᫨ኪ㛫࡛ኚ໬ࡋ࠿ࡘ▷ࡃ࡞ࡿ࡜⪃࠼ࡽࢀࡿࠋ⏕⫱ྍ⬟࡞ᮇ㛫ࡀࡋ࡚࠸ࡿࡇ࡜ࡀண᝿ࡉࢀࡿࠋ
㝈ࡽࢀࡿࡓࡵࠊ⥲✀Ꮚ⏕⏘㔞ࡣ㢌ᡴࡕ࡟࡞ࡿࠋ୍
᫖ᖺࡢㄪᰝ࡟࠾࠸࡚ࡣࠊ໭ᾏ㐨▼⊁ᕷࠊⲈᇛ┴᪉࡛ࠊኪ㛫ࡢ㏦⢊⪅ࡔࡅ࡛࡞ࡃኤᬽࢀ᫬ࡢ㏦⢊⪅ࡦࡓࡕ࡞࠿ᕷࠊ㫽ྲྀ┴⡿Ꮚᕷࡢ 3 ᆅⅬ࡟ࡘ࠸࡚ࠊ
ࡶ฼⏝ࡍࡿࡓࡵ࡟ࠊⰼࡢࢹ࢕ࢫࣉࣞ࢖ࢧ࢖ࢬࡢቑ
㔝እㄪᰝࢆ⾜ࡗࡓࠋㄪᰝ㡯┠ࡣࠊ(1)ⰼ࠾ࡼࡧ᳜≀ຍࡸࠊ㛤ⰼ᫬㛫ࡢኚ᭦࡞࡝ࡀほᐹࡉࢀࡿࡢ࡛ࡣ࡞
ಶయࡢᙧែⓗ≉ᚩࡢẚ㍑ࠊ (2)㛤ⰼࣇ࢙ࣀࣟࢪ࣮࠾
࠸࠿࡜࠸࠺ࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡇࡢ⪃ᐹ࡟ࡘ࠸࡚
ࡼࡧ㛤ⰼ᫬㛫ࡢ ᐃࢆ⾜࠸ゎᯒࡋࡓࠋࡇࡢ⤖ᯝࠊࡣ᫖ᖺࡼࡾ኱ࡁࡃኚࢃࡗ࡚ࡣ࠸࡞࠸ࡀࠊୖ㏙ࡢ㏻
ࡲࡎⰼࢧ࢖ࢬࡣ㧗⦋ᗘ࡟࡞ࡿ࡯࡝኱ࡁࡃ࡞ࡗࡓࠋ
ࡾ༑ศ࡟᳨ドࡍࡿࡓࡵ࡟ࡣ⛣᳜ᐇ㦂࡟ࡼࡿẚ㍑᳨
୍᪉ࠊಶయࢧ࢖ࢬࡣᾏᓊᆅᇦ࡛ᑠࡉࡃ࡞ࡗࡓࠋࡲ
ࡓࠊ⏕⏘ࡋࡓಶయ࠶ࡓࡾࡢ✀Ꮚ⏕⏘㔞ࡢ᥎ᐃ್ࡣࠊ ドࡀᚲせ࡛࠶ࡿࠋྛᆅᇦෆ࡛㛤ⰼ㛤ጞ᫬ࡢಶయࢧ࢖ࢬ࡜ṇࡢ┦㛵ࡀ࠶ࡗࡓࠋࡲࡓಶయࡢ㡬ⱆࡢⰼᩘࡣಶయࢧ࢖ࢬ࡟౫

−9−◊✲ᚑ஦⪅㸸ሷ㇂ᝆᕼ฼⏝≧ἣ࣭◊✲ᡂᯝᰁⰍయࡢಸᩘ໬ࡣࠊࢤࣀ࣒඲యࡀ」〇ࡉࢀࡿฟ᮶஦࡛࠶ࡾࠊከࡃࡢ᳜≀ࡢศ㢮⩌࡛☜ㄆࡉࢀ࡚࠸
ࡿࠋ୍ㄝ࡟ࡼࡿ࡜඲࡚ࡢ⿕Ꮚ᳜≀ࡣඹ㏻ࡢ♽ඛ✀ࡢಸᩘ໬࡟⏤᮶ࡋࠊࡲࡓ⥔⟶᮰᳜≀ࡢ 35%ࡀ᭱㏆ࡢಸᩘ໬ࢆ⤒㦂ࡋ࡚࠸ࡿ࡜ࡉࢀࠊಸᩘ໬ࡀ᳜≀ࡢከᵝᛶࡢ㥑ືຊ࡜࡞ࡗ࡚࠸ࡿࡇ࡜ࡀ♧၀ࡉࢀ࡚࠸
ࡿࠋಸᩘ໬ࡢ㐺ᛂⓗ࡞ព⩏࡟ࡘ࠸࡚ࡣࠊ⮬ᐙ࿴ྜᛶࡢ㐍໬ࡀಁ㐍ࡉࢀࡿࡇ࡜ࠊ」〇ࡉࢀࡓ㑇ఏᏊࡀ᪂ࡋ࠸ᶵ⬟ࢆ⋓ᚓࡍࡿࡇ࡜࡞࡝ࡀᣲࡆࡽࢀ࡚࠸ࡿ
ࡀࠊಸᩘ໬㞟ᅋࡢᡂ❧࣭⥔ᣢᶵᵓ࡟ࡘ࠸࡚ࡣ୙᫂
࡞Ⅼࡀከ࠸ࠋᮏ◊✲࡛ࡣࠊ✀ෆ࡟␗࡞ࡿಸᩘᛶࢱ࢖ ࣉ ࢆ ࡶ ࡘ ᯘ ᗋ ᳜ ≀ ࣑ ࣑ ࢥ ࢘ ࣔ ࣜ (Parasenecio
kamtschaticus)ࢆ⏝࠸࡚ࠊ♽ඛ㞟ᅋ࣭ಸᩘ໬㞟ᅋࡢ⦾Ṫ≉ᛶࢆẚ㍑ࡋࠊಸᩘ໬ࡢ㐺ᛂⓗ࡞ព⩏ࢆ᳨ウࡋࡓࠋㄪᰝᆅ࡜ࡋ࡚ 2 ಸయ㞟ᅋࠊ4 ಸయ㞟ᅋࠊࡑࡋ࡚
ᰤ㣴⦾Ṫయࡢ࣒࢝ࢦࢆᙧᡂࡍࡿ 4 ಸయኚ✀ࡢࢥࣔࢳ࣑࣑ࢥ࢘ࣔࣜ㞟ᅋ(௨ୗࢥࣔࢳ㞟ᅋ)ࢆ 2 㞟ᅋࡎࡘ㑅ᐃࡋࡓࠋ2 ಸయ㞟ᅋ࡜ࡋ࡚Ɫᑠ∾◊✲ᯘ࡜㔝ᖠ᳃ᯘබᅬࢆࠊ4 ಸయ㞟ᅋ࡜ࡋ࡚ኳሷ◊✲ᯘ࡜▱ᗋࢆࠊࡑࡋ࡚ࢥࣔࢳ㞟ᅋ࡜ࡋ࡚㉥ᓅ࡜୸℩ᕸࢆ㑅ࢇࡔࠋྛ㞟ᅋ࡛ᙧែᙧ㉁(ⴥᩘࠊⴥ㠃✚ࠊᆅ㝿┤ᚄࠊⲡ୔ࠊⰼᩘ)ࢆィ ࡋࠊ5 㞟ᅋ࡛ཷ⢊ᐇ㦂(↓ฎ⌮ࠊ௚ᐙཷ⢊ࠊ⿄ࡀࡅࡢࡳࠊ⮬ᐙཷ⢊)ࢆ⾜ࡗࡓࠋࡲࡓࠊ
2 ಸయⱢᑠ∾◊✲ᯘ࣭4 ಸయኳሷ◊✲ᯘ㞟ᅋ࠿ࡽࡑࢀࡒࢀ 15 ᰴࢆ໭ᾏ㐨኱Ꮫ࣭ࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮᪋タࡢᐇ㦂ᅡሙෆ࡟⛣᳜ࡋࠊࢱ࢖ࣉ㛫஺㞧ᐇ㦂ࢆ⾜ࡗࡓࠋ(1)ᙧែᙧ㉁ẚ㍑࡛ࡣࠊ4 ಸయࡣ 2 ಸయࡸࢥࣔࢳ㞟ᅋࡼࡾࡶⴥ㠃✚ࠊᆅ㝿┤ᚄࠊⲡ୔ࡀ኱ࡁࡃ࡞ࡿഴ
ྥࡀ࠶ࡗࡓࠋⴥᩘ࡜ⰼᩘࡣࢱ࢖ࣉ㛫࡛᫂░࡞ᕪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓࡀࠊⰼ⏕⏘ࡸⴥࢧ࢖ࢬࡢಶయࢧ
࢖ࢬ౫Ꮡᛶࡣࠊ4 ಸయ࡛ࡣ 2 ಸయࡸࢥࣔࢳ㞟ᅋࡼࡾࡶᑠࡉ࠸ࡇ࡜ࡀ♧ࡉࢀࡓࠋ௨ୖࡢ⤖ᯝ࠿ࡽࠊ4 ಸయࡣⴥࡸⰼࡢ⏕⏘ࡼࡾࡶᆶ┤᪉ྥ࡬ࡢఙ㛗ࢆඃඛࡍࡿ㈨※ᢞ㈨ᡓ␎ࢆࡶࡕࠊࡉࡽ࡟㧗࠸⫼୔ࡸ኱ࡁ࡞
ⴥ㠃✚ࢆ♧ࡍࡇ࡜࠿ࡽග⋓ᚓ➇த࡟᭷฼࡞ᙧ㉁ࢆ
ࡶࡘࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ᪤࡟▱ࡽࢀ࡚࠸ࡿಸᩘᛶ
ࡢศᕸ᝟ሗ࠿ࡽࠊࡇࡢࡼ࠺࡞ᙧ㉁ࢆࡶࡘ 4 ಸయ㞟ᅋࡀ㔪ᗈΰ஺ᯘࡼࡾࡶⷧᬯ࠸㔪ⴥᶞᯘࡢᯘᗋ࡛㑅ᢥࡉࢀ࡚ࡁࡓྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ(2)ཷ⢊ᐇ㦂ࡢ⤖ᯝࠊ࡝ࡢ㞟ᅋࡶ⮬ᐙ࿴ྜᛶࡀప࠸ࡇ࡜ࡀ♧ࡉࢀࡓࠋࡲࡓࠊࢱ࢖ࣉ㛫ཷ⢊ࡢ⤖ᯝࠊ2 ಸయ࡜ 4 ಸయࡢ㛫ࡢ࿴ྜᛶ㸦஺㞧࡟ࡼࡿ✀Ꮚ⏕⏘㸧ࡣప࠸ࡇ࡜ࡶ
♧ࡉࢀࡓࠋ௨ୖࡢ⤖ᯝ࠿ࡽࠊ2 ಸయ࡜ 4 ಸయࡢ㛫ࡢ⦾Ṫᖸ΅ࡢᏑᅾ࡟ࡶ࠿࠿ࢃࡽࡎࠊ4 ಸయࡀ⮬ᐙ࿴ྜᛶࡢ⋓ᚓࢆࡏࡎ࡟ศᕸࢆᣑ኱ࡋ࡚࠸ࡗࡓྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ࣑࣑ࢥ࢘ࣔࣜࡀከᖺⲡ࣭ከᅇ⦾Ṫᛶ୍࡛ᖺⲡ࡟ẚ࡭ᖸ΅ࡢຠᯝࡀ⌧ࢀ࡟ࡃ࠸ࡇ࡜ࠊ2
ಸయ࡜ 4 ಸయࡢ㛫࡟஺㓄๓ࡢ㝸㞳ᶵᵓࡀᏑᅾࡍࡿ
ࡇ࡜࡞࡝ࡢせᅉࡀࡇࡢࡼ࠺࡞ศᕸᣑ኱࡟ᐤ୚ࡋࡓ
ྍ⬟ᛶࡀ࠶ࡾࠊ௒ᚋࡢヲ⣽࡞ㄪᰝࡀᚲせ࡛࠶ࡿࠋ௒ᚋࡣࠊࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮᪋タ࡟⛣᳜ࡋࡓಶయࢆ⏝࠸ࠊ௨ୗࡢㄪᰝࢆ⾜࠺ணᐃ࡛࠶ࡿࠋ1)஺㓄๓㝸㞳ࢆㄪ࡭ࡿࡓࡵ࡟㛤ⰼ᫬ᮇࢆࢱ
࢖ࣉ㛫࡛ẚ㍑ࡍࡿࠋ2)ᅡሙ࡬ࡢ⛣᳜ࢆ⾜ࡗࡓ 2020ᖺࡢ஺㞧ᐇ㦂ࡢ⤖ᯝࡣࠊ⛣᳜࡟క࠺ᰴ࡬ࡢࢲ࣓࣮
ࢪࡢᙳ㡪ࡀ⪃࠼ࡽࢀࡿࡓࡵࠊࢧࣥࣉࣝᩘࢆቑࡸࡋ
࡚㏣ຍࡢࢱ࢖ࣉ㛫஺㞧ᐇ㦂ࢆ⾜࠺ࠋᏛ఍Ⓨ⾲ሷ㇂ᝆᕼᕤ⸨ᓅᯘᗋ᳜≀࣑࣑ࢥ࢘ࣔࣜࡢಸᩘ
ᛶኚ␗࡜⦾Ṫ≉ᛶ ᖺᗘ᪥ᮏ⏕ែᏛ఍໭ᾏ㐨ᆅ༊኱఍ ᖺ  ᭶  ᪥zoom ࡟ࡼࡿ࢜ࣥࣛ
࢖ࣥ㛤ദ

኱Ꮫ㝔⌮Ꮫ◊✲㝔≀⌮Ꮫ㒊㛛 㔞Ꮚ≀⌮Ꮫศ㔝ᯇỌ ᝅ᫂㸦⣧Ỉ฼⏝㸧ㄽᩥⓎ⾲
Thermodynamic Investigation on Antiferromagnetic
Ordered State of the Molecular π-d System
λ-(BEDT-STF)(2)FeCl4
Fukuoka, S; Minamidate, T; Matsunaga, N; Ihara, Y;
Kawamoto, A
JOURNAL OF THE PHYSICAL SOCIETY OF
JAPAN 7 073704 (2020)
Ꮫ఍Ⓨ⾲"Co-appearance of high-Tc superconductivity andferromagnetism in Ca2RuO4 nanocrystals",
H. Nobukane, K. Yanagihara, Y. Kunisada, Y.
Ogasawara, K. Isono, K. Nomura, K. Tanahashi, T.
Nomura, T. Akiyama, and S. Tanda, The APS March
Meeting 2021. March 15-19 2021, ONLINEᨃ୍ḟඖ᭷ᶵᑟయ(DMET-TTF)2AuBr2 ࡢ㟁Ꮚ≀ᛶ III
㣤⏣⍱ᖹ, బࠎᮌ⩏᫂, ᅵᒇᬛᩗ, ⃝⏣㈼ᚿ, ᯇỌᝅ᫂, Ἑᮏ඘ྖ, 㔝ᮧ୍ᡂ. ᪥ᮏ≀⌮Ꮫ఍ 2020 ᖺ⛅Ꮨ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧2020 ᖺ 9 ᭶ 8 ᪥㹼11 ᪥
π-d ⣔≀㉁ λ-(BEDT-STF)2FeCl4 ࡢㄏ㟁≉ᛶ⚟ᒸ⬶ᖹ, ఀ⸨ᝆ㤿, 㧗ᶫோᚨ, ᯇỌᝅ᫂, ஭ཎ៞ᙪ, Ἑᮏ඘ྖ. ᪥ᮏ≀⌮Ꮫ఍ 2020 ᖺ⛅Ꮨ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧2020 ᖺ 9 ᭶ 8 ᪥㹼11 ᪥
Fe1+xTe ࡢㄏ㟁⋡ ᐃ III
ᶓ஭༓⇊, ᐑᔘ୍ㄔ, 㔠஭ᜤభ, ᕷᮧ᫭୍, ୹⏣⪽,ᯇỌᝅ᫂, 㯮⃝ᚭ. ᪥ᮏ≀⌮Ꮫ఍ 2020 ᖺ⛅Ꮨ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧2020 ᖺ 9 ᭶ 8 ᪥㹼11 ᪥− 10 −

π-d 㟁Ꮚ⣔ࡢ཯ᙉ☢ᛶඹ㬆኱ᓥຬ࿃, Taehoon Lee, Hengbo Cui, ༡⯓Ꮥு, ᩪ⸨ὒᖹ, Ἑᮏ඘ྖ, ᯇỌᝅ᫂, ຍ⸨♩୕. ᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧2021 ᖺ 3 ᭶
12 ᪥㹼15 ᪥ᨃ୍ḟඖ᭷ᶵᑟయ(DMET-TTF)2AuBr2 ࡢ㟁Ꮚ≀ᛶ IV
ຍ⸨኱㈡, 㣤⏣⍱ᖹ, బࠎᮌ⩏᫂, ᅵᒇᬛᩗ, ⃝⏣㈼ᚿ, ᯇỌᝅ᫂, Ἑᮏ඘ྖ, 㔝ᮧ୍ᡂ. ᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧2021 ᖺ 3 ᭶ 12
᪥㹼15 ᪥
ࢼࣀࢫࢣ࣮ࣝ NbS3 ࡢ㍺㏦⌧㇟⚟⏣㞝ኴ, ᘏවၨ⣧, ᑠ㔝ᑎ㬨␇, ㏕⏣ᑘோ, ୰ὠᕝၨ἞, Ụⰼ᫛ဢࢩ࣮ࣙࣥ, ᶓ஭༓⇊, ᑎすඃኴ㑻, ୹⏣⪽. ᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧2021 ᖺ 3 ᭶ 12 ᪥㹼15 ᪥ࢼࣀࢫࢣ࣮ࣝ TaSe3 ࡢ㟁Ꮚ㍺㏦⌧㇟ᑠ㔝ᑎ㬨␇, ᘏවၨ⣧, 㔝ᮧ , ⚟⏣㞝ኴ, ᒣ㇂࿴ᙪ, 㧗ᰗ⁠, ୹⏣⪽. ᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧2021 ᖺ 3 ᭶ 12 ᪥㹼15 ᪥≀⌮Ꮫ㒊㛛 㟁Ꮚ≀ᛶ≀⌮Ꮫศ㔝Ἑᮏ ඘ྖ㸦⣧Ỉ฼⏝㸧ㄽᩥ
Kobayashi, T., Ishikawa, T., Ohnuma, A., Sawada, M.,
Matsunaga, N., Uehara, H., and Kawamoto, A. (2020)
Spin-density wave in the vicinity of superconducting
state in O-(BETS)2GaBrxCl4-x probed by 13C NMR
spectroscopy. Physical Review Research 2: 023075.
Fukuoka, S., Minamidate, T., Ihara, Y., and Kawamoto, A.
(2020) Selective observation of sublattice magnetizationin the molecular S-d system λ-(BEDT-STF)2FeCl4
studied by 13C NMR. Physical Review B 101: 184402.
Ihara, Y., Yoshida, H., Arashima, K., Hirata, M., andSasaki, T. (2020) Anisotropic magnetic excitations fromsingle-chirality antiferromagnetic state in Ca-kapellasite.
Physical Review Research 2: 023269.
Fukuoka, S., Minamidate, T., Matsunaga, N., Ihara, Y.,
and Kawamoto, A. (2020) Thermodynamic Investigation
on Antiferromagnetic Ordered State of the Molecular
S-d System O-(BEDT-STF)2FeCl4. Journal of the
Physical Society of Japan 89: 073704.
Ishikawa, H., Yajima, T., Matsuo, A., Ihara, Y., andKindo, K. (2020) Nonmagnetic Ground States and a
Possible Quadrupolar Phase in 4d and 5d Lacunar
Spinel Selenides GaM4Se8 (M = Nb, Ta). PhysicalReview Letters 124: 227202.
Kanda, T., Arashima, A., Hirose, Y., Settai, R., Matsui,K., Nomura, T., Kohama, Y., Ihara, Y. (2020) Symmetry
Lowering on the Field-Induced Commensurate Phasein CeRhIn5. Journal of the Physical Society of Japan
89: 094709.
Sawada, M., Kawamoto, A., and Kobayashi, T. (2021)
Enhancement of electron correlations and spin density
wave fluctuations of the organic superconductorλ-(BETS)2GaCl4 under pressure proved by 13C NMR.
Physical Review B 103: 045112.
Ihara, Y., Matsui, K., Kohama, Y., Luther, S., Opherden,D., Wosnitza, J., Kühne, H., and Yoshida, H. (2021)
Emergence of Frustrated Short-Range Order above
Long-Range Order in the S = 1/2 Kagome
Antiferromagnet CaCu3(OD)6Cl2∙0.6D2O. Journal of
the Physical Society of Japan 90: 023703.
Matsui, K., Kanda, T., Ihara, Y., Kindo, K., andKohama, Y. (2021) Compact megajoule-class pulsed
power supply for generating long-pulsed magnetic
fields. Review of Scientific Instruments 92: 024711.
Fukuoka, S., Haruyama, K., Ihara, Y., and Kawamoto, A.
(2021)
EffectsofAnion
Substitutionon
Unconventional Antiferromagnetic Ground State of
Molecular S-d system O-(BEDT-STF)2FexGa1-xCl4.
Journal of the Physical Society of Japan Accepted.
Ꮫ఍Ⓨ⾲ᅜෆᏛ఍
⚟ᒸ⬶ᖹ, ఀ⸨ᝆ㤿, 㧗ᶫோᚨ, ᯇỌᝅ᫂, ஭ཎ៞ᙪ, Ἑᮏ඘ྖ㸸S -d ⣔≀㉁O-(BEDT-STF)2FeCl4 ࡢㄏ㟁≉ᛶ㸬᪥ᮏ≀⌮Ꮫ఍ 2020 ᖺ⛅Ꮨ኱఍㸪2020 ᖺ 9 ᭶ 11 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ㸬஭ཎ៞ᙪ, ᯇ஭୍ᶞ, ᑠ℈ⰾඔ, ྜྷ⏣⣫⾜㸸
2
D-NMR ᐃ࡟ࡼࡿ CaCu3(OH)6࣭0.6H2O ࡢ▷㊥㞳┦㛵≧ែࡢ◊✲㸬᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸪2021 ᖺ 3 ᭶ 12 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ㸬ᯘ㤾, ୗᶫṇ࿴, ஭ཎ៞ᙪ, ⚄⏣᭸ᕼ, ᯇ஭୍ᶞ,ᑠ℈ⰾඔ, ᮌᮧ೺ኴ, ᮌᮧ๛㸸ࣃࣝࢫ☢ሙ୰ NMRᐃ࡟ࡼࡿ Pb(TiO)Cu4(PO4)4 ࡢ☢ሙㄏ㉳☢Ẽ⛛ᗎ≧ែࡢ◊✲㸬
᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸪2021 ᖺ 3 ᭶ 14 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ㸬ᒸኴ⪀, Ἑᮏ඘ྖ, ⃝⏣㈼ኈ, ▼ᕝ㈗Ꮚ, ᑠᯘᣅ▮㸸λ-(BETS)2GaBrxCl4-x(x = 0.9) ࡢ 13C-NMR㸬᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸪2021 ᖺ 3 ᭶ 14 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ㸬Ἑᮏ඘ྖ, ⚟ᒸ⬶ᖹ, ᑠᕝᕦ┿, ఀ⸨ᝆ㤿, ఀ⸨᭷ဏ , ᑠ ᯘ ᣅ ▮ , ㇂ ཱྀ ᘯ ୕ 㸸 λ-(BEST)2GaCl4 ሷ ࡢ
69,71
Ga-NMR㸬᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸪2021 ᖺ 3 ᭶ 14 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ㸬− 11 −

ఀ⸨ᝆ㤿, ᫓ᒣ࿴ᕼ, ⚟ᒸ⬶ᖹ, ஭ཎ៞ᙪ, Ἑᮏ඘ྖ㸸λ-(BEDT-STF)2FexGa1-xCl4 ࡟࠾ࡅࡿ☢Ẽ⛛ᗎࡢᏳᐃ໬㸬᪥ᮏ≀⌮Ꮫ఍➨ 76 ᅇᖺḟ኱఍㸪2021 ᖺ 3 ᭶ 14 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ㸬㒊㛛 ᙧែᶵ⬟Ꮫศศ㔝⏕≀⛉Ꮫ㒊బ⸨ 㛗⥴1) ᳜≀ࡀ⢾/❅⣲㸦C/N㸧ᰤ㣴ࣂࣛࣥࢫ࡟ᛂ⟅ࡍࡿศᏊᶵᵓ࡟ࡘ࠸࡚㸪⣽⬊ෆࣜࣥ㓟໬ࢩࢢࢼࣝఏ㐩ࢿࢵࢺ࣮࣡ࢡ࡟ࡘ࠸࡚⥙⨶ⓗ࡟ゎᯒࡋࡓ◊✲ࠋࢩࣟ࢖ࢾࢼࢬࢼࢆᮦᩱ࡟㸪ࣜࣥ㓟໬ࣉࣟࢸ࣮࣒࢜ゎᯒࢆᐇ᪋ࡋ㸪ࡇࢀࡲ࡛࡟࡞࠸኱つᶍ࡞ C/N ࢩࢢࢼࣝఏ㐩ࢿࢵࢺ࣮࣡ࢡࡢ᝟ሗࡀᚓࡽࢀࡓࠋࡲࡓ㸪ᰤ㣴ࢩࢢࢼࣝ࡜⣽⬊Ṛไᚚ࡟㛵ࢃࡿ᪂つཷᐜయᆺ࢟
ࢼ࣮ࢮ LMK1 ࢆ༢㞳ࡋࡓࠋ[Li et al, Frontiers in
Plant Science 2020]
2㸧
AtNOT1 ࡢኚ␗ᰴࡀ㞝ᛶ㓄അయ⮴Ṛ࡜࡞ࡿࡢࡣ㸪ⰼ⢊ࡢᙧᡂ㜼ᐖࡀཎᅉ࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
࣊ࢸࣟ᥋ྜయࢆ⏝࠸ࡓゎᯒ࠿ࡽ㸪ⰼ⢊ᙧᡂ᫬ࡢ㈇ࡢⓎ⌧ไᚚ࡟㛵ࢃࡗ࡚࠸ࡿྍ⬟ᛶࢆ♧ࡋࡓࠋ
[Motomura et al, Plant and Cell Physiology 2020]3㸧ࢩࣟ࢖ࢾࢼࢬࢼࡢ࣍࢘⣲⃰ᗘ࡟ᛂ⟅ࡋࡓ᭱ᑠ
uORF ࡟ࡼࡿ⩻ヂไᚚࢆ⥙⨶ゎᯒ࡟ࡼࡾ᫂ࡽ࠿࡟
ࡋࡓࠋ[Sotta et al, Plant Journal 2021]
4) ࣔࢹࣝస≀✀࡛࠶ࡿࢺ࣐ࢺࡢᯝᐇࢆ⏝࠸ࡓࣉࣟࢸ࣮࣒࢜ゎᯒᡭἲ࡟㛵ࡋ࡚ᇳ➹ࡋࡓࠋᯝᐇ࡟࠾
ࡅࡿ௦ㅰ㓝⣲ࡢάᛶไᚚ࡟㛵ࢃࡿ 14-3-3 ࢱࣥࣃࢡ㉁ࡢᶆⓗᅉᏊ࡟ࡘ࠸࡚㸪ᙜ◊✲ᐊ࡛ᐇ᪋ࡋࡓࣁ࢖
ࢫ࣮ࣝࣉࢵࢺ࠿ࡘ⥙⨶ⓗ࡞ࣉࣟࢸ࣮࣒࢜ゎᯒᡭἲ࡟ࡘ࠸࡚ゎㄝࡋࡓࠋ[Luo et al, “Plant Proteomics:
Methods and Protocol, Third Edition” 2020]㸺ཎⴭㄽᩥ㸼
Li, X., Sanagi, M., Yu, L., Nomura, Y., Stolze, S.C.,
Yasuda, S., Saijo, Y., Schulze, W.X., Feil, R.,
Lunn, J.E., Stitt, M., Nakagami, H.*, Sato, T.* andYamaguchi, J. (2020) Protein phosphorylation
dynamics under carbon/nitrogen-nutrient stressand identification of a cell death-related
receptor-like kinase in Arabidopsis. Frontiers in
Plant Science, 11: 377
Motomura K.†, Toshihiro Arae T.†, (†co-firstauthors) Uramoto A. H., Suzuki Y., Takeuchi H.,
Suzuki T., Ichihashi Y., Shibata A., Shirasu K.,
Takeda A., Higashiyama T., Chiba Y.* (2020)
AtNOT1 is a novel regulator of gene expression
during pollen development. Plant Cell. Physiol.
61: 712-721
Sotta N.†*, Chiba Y.† (†co-first authors), Miwa K.,
Takamatsu S., Tanaka M., Yamashita Y., Naito S.*,
Fujiwara T.* (2021) Global analysis ofboron-induced ribosome stalling reveals its effects
on translation termination and unique regulation
by AUG-stops in Arabidopsis shoots. Plant J. in
press
㸺⥲ㄝ㸼
Luo, Y., Lu, Y., Yamaguchi, J. and Sato, T. (2020)
Chapter 21, Proteome analysis of 14-3-3 targets intomato fruit tissues. In “Plant Proteomics:
Methods and Protocol, Third Edition” (edited by
J.V. Jorrín Novo, L. Valledor, and M.A. Castillejo)
Methods in Molecular Biology, Springer Protocol,
Humana Press, 2139: 289-296⏕≀⛉Ꮫ㒊㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศศ㔝ᑠᕝ ᏹே
௧࿴㸰ᖺᗘ◊✲ᡂᯝᐇ㦂⏕≀ඹྠ฼⏝㒊㛛࡛㣫⫱ࡋࡓࣇࢱ࣍ࢩࢥ࢜ࣟ
ࢠ㸦Gryllus bimaculatus㸧ࢆᮦᩱ࡜ࡋ࡚㺂⚄⤒⏕≀Ꮫⓗᐇ㦂ࢆ⾜ࡗࡓࠋ
ࢥ࢜ࣟࢠࡣ㺂⭡㒊ᮎ➃ࡢᑿⴥ࡜࿧ࡤࢀࡿᶵᲔឤぬჾᐁ࡛✵Ẽὶ᣺ືࢆཷᐜࡋ㺂▷࠸Ẽὶ่⃭࡟ᑐࡋ࡚⣲᪩ࡃ㐲ࡊ࠿ࡿṌ⾜⾜ືࢆ♧ࡍࠋࡇࡢ⾜ືࡣẼὶࢆᤕ㣗⪅ࡢ᥋㏆࡜ᤊ࠼㺂ᤕ㣗࠿ࡽ㏨ࢀࡼ࠺࡜
ࡍࡿ㏨㑊⾜ື࡛࠶ࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋࡲࡓ㺂࢜ࢫࢥ࢜ࣟࢠࡢⓎࡍࡿㄏᘬḷ࡟ᑐࡋ࡚࣓ࢫࡣ㡢※࡟㏆௜࠸࡚࠸ࡃ᥋㏆⾜ື㸦㡢※ᐃ఩㸧ࢆ♧ࡍࠋᡃࠎࡣ
ࡇࢀࡲ࡛࡟㺂Ẽὶឤぬ᝟ሗฎ⌮ࡢ⚄⤒ᶵᵓ࡜Ẽὶ
ㄏᑟᛶ㏨㑊⾜ື㺂ཬࡧ㡢※ᐃ఩⾜ື࡟㛵ࡍࡿ⚄⤒⾜ືᏛⓗ◊✲ࢆ⾜ࡗ࡚ࡁࡓࠋᮏᖺᗘࡣ௨ୗࡢẼὶ
ㄏᑟᛶ㏨㑊⾜ື࡟㛵ࡍࡿ◊✲ᡂᯝࢆᚓࡓࠋ
Ẽὶ㏨㑊⾜ື࡟ᑐࡍࡿゐゅࢆ௓ࡋࡓᶵᲔឤぬධຊࡢᙳ㡪ឤぬჾᐁ࡞࡝ࢆ⬟ືⓗ࡟ື࠿ࡋ࡚᝟ሗࢆᚓࡓࡾ㸪⮬ࡽᨺࡗࡓ㡢Ἴࡢ཯ᑕ࠿ࡽ≀యࢆ▱ぬࡋࡓࡾࡍࡿ
ࡇ࡜ࢆ࢔ࢡࢸ࢕ࣈࢭࣥࢩࣥࢢ࡜࿧ࡪࠋࢥ࢜ࣟࢠࡣ
㢌㒊ࡢゐゅࢆ⮬Ⓨⓗ࡟ື࠿ࡋ࡚≀య࡟᥋ゐࡉࡏ㸪ࡑࡢᶵᲔឤぬධຊ࠿ࡽ≀య࡟ᐃ఩ࡍࡿࡇ࡜ࡣሗ࿌
ࡉࢀ࡚࠸ࡿࡀ㸪ゐゅࡢྛࢸ࢕㒊ࢭࣥࢩࣥࢢ࡟ࡼࡗ
࡚࿘ᅖࡢ✵㛫ࢆ▱ぬࡋ࡚࠸ࡿ࠿ࡣ୙࡛᫂࠶ࡗࡓࠋ
ࡑࡇ࡛ࠊࢥ࢜ࣟࢠࡀゐゅࢆ౑ࡗ࡚✚ᴟⓗ࡟᥋ゐ࡛ࡁࡿࡼ࠺࡞ሙᡤ࡟ࠊᙧ≧ࡢ␗࡞ࡿ≀యࢆタ⨨ࡋ㸪Ẽὶ่⃭࡟ᑐࡍࡿ㏨㑊⾜ື࡬ࡢᙳ㡪ࢆㄪ࡭ࡓࠋ
ࡑࡢ⤖ᯝ㸪ࢥ࢜ࣟࢠࡣ㸪≀యࡢᙧ≧ࡸ఩⨨࡟ᛂࡌ࡚㸪㞀ᐖ≀࡜ࡢ⾪✺ࢆᅇ㑊ࡍࡿࡼ࠺࡟㏨㑊⾜ືࡢ⛣ື⤒㊰ࢆኚ࠼ࡓࠋẼὶ่⃭࡟ࡼࡿ㏨㑊⾜ືࡣ㸪ゐゅ࡛ࡣ࡞ࡃ⭡㒊ᑿⴥჾᐁࢆ௓ࡋ࡚ᘬࡁ㉳ࡇࡉࢀࡿࡇ࡜࠿ࡽ㸪ࢥ࢜ࣟࢠࡣゐゅࢆ௓ࡉ࡞࠸ูࡢ่⃭࡟ࡼࡿ⾜ື࡛࠶ࡗ࡚ࡶ㸪ゐゅ࡛▱ぬࡋࡓ≀యࡢ✵㛫᝟ሗ࡟ࡼࡗ࡚⾜ືࢆኚᐜࡋ࠺ࡿ࡜⪃࠼ࡽࢀࡿࠋ
ࡇࡢ⤖ᯝࡣࢥ࢜ࣟࢠࡀゐゅࡢ࢔ࢡࢸ࢕ࣈࢭࣥࢩࣥ

− 12 −

(2020). Internal state transition to switch behavioralࢢ࡟ࡼࡗ࡚࿘ᅖࡢ≀య࡟㛵ࡍࡿ✵㛫ㄆ㆑ࢆࡋ࡚࠸
strategies in cricket phonotaxis behavior. Journal ofࡿࡇ࡜ࢆ♧၀ࡍࡿࡶࡢ࡛࠶ࡿࠋࡲࡓ㸪ࢥ࢜ࣟࢠࡢ
Experimental Biology, 223: jeb229732.
๓࡟ቨࢆ⨨ࡁࠊࢥ࢜ࣟࢠࡢ࢔ࣥࢸࢼࡢ∦ഃ࡛ቨࢆ2) Maekawa, T., Ohara, K., Zhang, Y., Fukutomi, M.,᳨▱ࡍࡿࡼ࠺࡟ࡋࡓሙྜࠊᚋࢁ࠿ࡽࡢ่⃭࡟ᑐࡍMatsumoto, S., Matsumura, K., Shidara, H., Yamazaki, S.,
ࡿ㏨㑊⾜ືࡣࠊቨ࡜཯ᑐഃ࡟኱ࡁࡃ೫ࡗࡓࠋࡋ࠿
Fujisawa, R., Ide, K., Nagaya, N., Yamazaki, K., Koike,ࡋࠊቨࡢ࡞࠸཯ᑐഃࡢ࢔ࣥࢸࢼࢆษ㝖ࡍࡿ࡜ࠊࡇ
S., Miyatake, T., Kimura, K., Ogawa, H., Takahashi, S.
ࡢ⾪✺ࢆ㑊ࡅࡿࡓࡵࡢ⤒㊰ኚ໬ࡣࡳࡽࢀ࡞ࡃ࡞ࡗ
and Yoda K. (2020). Deep learning-assisted comparativeࡓࠋ௨ୖࡢ⤖ᯝ࠿ࡽ㸪ቨ࡟ゐࢀ࡚࠸࡞࠸ഃࡢゐゅanalysis of animal trajectories with DeepHL. Nature
Communications, 11: 5316.
࠿ࡽࡣ༢࡟ධຊࡀ࡞࠸ࡢ࡛ࡣ࡞ࡃ㸪㞀ᐖ≀ࡀࠕ࡞࠸ࠖ࡜࠸࠺᝟ሗࢆᥦ౪ࡋ࡚࠸ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋᅜෆᏛ఍Ⓨ⾲ᮏ◊✲࡟ࡼࡾࠊࢥ࢜ࣟࢠࡣ࢔ࣥࢸࢼࢩࢫࢸ࣒ࢆ⏝ᑠᕝᏹே㸦2020㸧. ࢥ࢜ࣟ࠸ࡓ⬟ືⓗ࡞ࢭࣥࢩࣥࢢ࡟ࡼࡾࠊ≀యࡢ᭷↓࡞࡝ 1㸧 బ⸨࿴㸪タᵹஂᚿ㸪ᑠࢠẼὶ㏨㑊⾜ື࡟࠾ࡅࡿ⾜ື㑅ᢥࡢ⚄⤒ᇶ┙.
᪥ࡢ✵㛫᝟ሗࢆㄆ㆑࡛ࡁࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋᮏື≀Ꮫ఍➨ 91 ᅇ㸪2020 ᖺ 9 ᭶ 4ࠥ5 ᪥㸪࢜ࣥࣛẼὶㄏᑟᛶ㏨㑊⾜ືࡢ⾜ື㑅ᢥ࡜㐠ືไᚚ࡟࠾ࡅ
࢖ࣥ㛤ദࡿ⬻-⬚㒊⚄⤒⠇㐃⤡ࡢᶵ⬟ࡢゎ᫂
2㸧 ᮌᮧ㡪, ⚟ᐩཪ୕㑻, ᑠᕝᏹே, ᰿ᮾ▱ኸ, ᪥㧗ࢥ࢜ࣟࢠ࡛ࡣࠊẼὶ่⃭ࡢᙉᗘࡸゅᗘࡢ᝟ሗࡣ
ᖿஓ, ᒸ⏣஧㑻, Ἑ➃㞝Ẏ㸦2020㸧. ࡞ࡐࢥ࢜ࣟࢠ
᭱⤊⭡㒊⚄⤒⠇ෆ࡛ᢳฟࡉࢀࠊࡑࡇ࠿ࡽᕧ኱௓ᅾ
ࡣ㡢ࢆ⪺ࡃ࡜✵Ẽὶ่⃭࡟ᑐࡍࡿ㏨㑊⾜ືࢆኚ໬ࢽ࣮ࣗࣟࣥ㸦GIs㸧࡟ࡼࡗ࡚⬻ࡸ⬚㒊⚄⤒⠇࡟㐠ࡤࡉࡏࡿࡢ࠿㸸ᤕ㣗⪅ࢩ࣑࣮ࣗࣞࢩࣙࣥ࡟ࡼࡿ㏨㑊
ࢀࡿࠋࡇࢀࡽࡢ㧗ḟ⚄⤒୰ᯡ࡛⾜ື㑅ᢥࡸ㐠ືไ
ᡂຌุᐃ. ᪥ᮏື≀Ꮫ఍➨ 91 ᅇ㸪2020 ᖺ 9 ᭶ 4ࠥᚚ࡟ᙳ㡪ࡍࡿẼὶ่⃭ࡢ᝟ሗฎ⌮ࡀ⾜ࢃࢀ࡚࠸ࡿ
5 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ࡜⪃࠼ࡽࢀࡿࡀࠊ⬻ࡸ⬚㒊⚄⤒⠇ࡀ࡝ࡢࡼ࠺࡞ᙺ 3㸧 ᑠ ᕝᏹே㸪ᯘ⏣㈼ᶞ㸪⏥ᩫຍᶞ᮶㸪タᵹஂᚿ๭ࢆᣢࡘ࠿ࡣ୙࡛᫂࠶ࡿࠋࡑࡇ࡛ࠊ⭡ഃ⦪㐃ྜ⚄
㸦2020㸧. ࢥ࢜ࣟࢠ⬻ෆࢽ࣮ࣗࣟࣥ࡟࠾ࡅࡿ⫈ぬ⤒᮰ࢆ␗࡞ࡿ఩⨨࡛ษ᩿ࡋ࡚⬻ࡸ⬚㒊⚄⤒⠇࡬ࡢ่⃭࡜ᶵᲔឤぬ่⃭࡟ᑐࡍࡿከឤぬᛂ⟅ࡢ᪉ྥ㑅ୖ⾜ᛶಙྕ㸦ឤぬ᝟ሗධຊ㸧ࡸ⬻࠿ࡽࡢୗ⾜ᛶಙ
ᢥᛶ. Neuroscience 2020̾➨ 43 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ྕ㸦㐠ືྖ௧ฟຊ㸧ࢆ㐽᩿ࡋࠊ㏨㑊⾜ື࡟࠾ࡅࡿ
̾㸪2020 ᖺ 7 ᭶ 29 ᪥ࠥ8 ᭶ 1 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദྛ㧗ḟ୰ᯡࡢᶵ⬟ࢆㄪ࡭ࡓࠋࡲࡎࠊᕥྑࡢ⦪㐃ྜࢆ⬻-⬚㒊⚄⤒⠇㛫࡛ษ᩿ࡍࡿ࡜㏨㑊⾜ືࡀᾘኻ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศศ㔝⏕≀⛉Ꮫ㒊ࡋࡓࡓࡵࠊẼὶ㏨㑊⾜ືࢆ⾜࠺࡟ࡣ⬻࡜⬚㒊ࡢ⚄ỈἼ ㄔ
⤒㐃⤡ࡀᚲ㡲࡛࠶ࡿࡇ࡜ࡀศ࠿ࡗࡓࠋḟ࡟ࠊ➨㸲᭱⤊⭡㒊⚄⤒⠇㛫ࡲࡓࡣ⬻-⬚㒊⚄⤒⠇㛫࡛⦪㐃ࢥ࢜ࣟࢠࡢႴዲᛶ࠾ࡼࡧᚷ㑊ᛶ♫఍Ꮫ⩦ࡢ࣓ྜࢆ∦ഃࡔࡅษ᩿ࡋࡓࠋ๓⪅࡛ࡣ⬻࣭⬚㒊⚄⤒⠇࢝ࢽࢬ࣒ࡢ᥈⣴ඹ࡟∦ഃࡢୖ⾜ᛶಙྕࡀኻࢃࢀ㸪ᚋ⪅࡛ࡣ⬚㒊⚄ ⚾㐩ࡣࠊࢥ࢜ࣟࢠࡀ௚ಶయࡢ⾜ືࢆほᐹࡍࡿࡇ⤒⠇⬻࡬ࡣ୧ഃᛶࡢୖ⾜ᛶಙྕࡀ⥔ᣢࡉࢀ࡚࠸ࡿ
࡜࡛⮬ࡽ┤᥋⤒㦂ࡍࡿࡇ࡜࡞ࡃᏛ⩦ࡍࡿ♫఍Ꮫ⩦ࡀࠊ⬻࡟ᑐࡋ࡚ࡣୖ⾜ᛶಙྕ࡜⬚㒊࡬ࡢୗ⾜ᛶಙࡢ⬟ຊࢆᣢࡘࡇ࡜ࢆࡍ࡛࡟Ⓨぢࡋ࡚࠸ࡿࠋࡇࡢᏛ
ྕࡀࡑࢀࡒࢀ∦ഃ㐽᩿ࡉࢀ࡚࠸ࡿࠋࡑࡢ⤖ᯝࠊ⬚⩦⌧㇟࡟ࡘ࠸࡚ࡢゎᯒࢆ⾜ࡗࡓࠋ㒊⚄⤒⠇࡬ࡢ୧ഃᛶࡢୖ⾜ᛶಙྕධຊࡀ࠶ࢀࡤୗ
♫఍Ꮫ⩦ࡢカ⦎࡟⏝࠸ࡓ⿦⨨ࡣࠊࠕࢹࣔࣥࢫࢺࣞ
⾜ᛶಙྕࡀ∦ഃࡔࡅ࡛ࡶ running ࡍࡿࡇ࡜ࡀ࡛ࡁ
࣮ࢱࠖᐊ࡜ࠕほᐹ⪅ࠖᐊ࠿ࡽ࡞ࡾࠊ୧ᐊࡣ⥙࡛௙ࡓࡀࠊjumping ࡟ࡣ⬻࡬ࡢ୧ഃᛶࡢୖ⾜ᛶಙྕධຊ
ษࡽࢀ࡚࠸ࡿࠋࢹࣔࣥࢫࢺ࣮ࣞࢱᐊ࡟ࡣ␗࡞ࡿໝࡀᚲせ࡛࠶ࡗࡓࠋࡲࡓࠊ⛣ື᪉ྥࡸ⛣ື㏿ᗘ㸪㊥࠸ࢆⓎࡍࡿᑠᐜჾࡀ㸰ࡘ⨨࠿ࢀࠊ୍᪉࡟ࡣỈࡀࠊ㞳ࡢไᚚ࡟ࡣ⬻࠿ࡽࡢୗ⾜ᛶಙྕࡀᚲせ࡛࠶ࡗࡓࠋ ௚᪉࡛ࡣሷỈࢆ࠾࠿ࢀࡓࠋࡇࡢ㒊ᒇ࡟ 3 ᪥㛫⤯Ỉࡉࡽ࡟ࠊrunning ࡜ jumping ࡟ඛ⾜ࡋ࡚⬻࠿ࡽ㏦ࡽ
ࡉࡏࡓࢹࣔࣥࢫࢺ࣮ࣞࢱࢥ࢜ࣟࢠࢆධࢀࠊ㸳ศ㛫ࢀࡿୗ⾜ᛶಙྕࢆ⣽⬊እグ㘓࡟ࡼࡗ࡚ㄪ࡭ࡓ࡜ࡇ
⮬⏤࡟᥈⣴ࡉࡏࠊࡑࡢ⾜ືࢆࠕほᐹ⪅ࠖᐊ࡟ධࢀ
ࢁࠊjumping ࡢ㝿࡟ࡣ running ࡼࡾ⾜ື㛤ጞ┤๓࡟ࡓほᐹ⪅ࢥ࢜ࣟࢠ࡟⥙㉺ࡋ࡟ほᐹࡉࡏࡓࠋࢹࣔࣥ
ᛴ⃭࡞ୗ⾜ᛶಙྕࡢάືቑຍࡀ⏕ࡌࡿࡇ࡜ࡀ☜ㄆࢫࢺ࣮ࣞࢱࢥ࢜ࣟࢠࡣỈࡢ࠶ࡿᐜჾࢆゼၥࡍࡿ࡜ࠊ
ࡉࢀࡓࠋࡇࢀࡽࡢ⤖ᯝ࠿ࡽࠊ⬻࡛Ỵᐃࡉࢀࡓ㑅ᢥ㛗᫬㛫⁫ᅾࡋ࡚㣧ỈࡋࡓࡀࠊሷỈࡢᐜჾࢆゼၥࡋ⤖ᯝ࡟ᇶ࡙࠸࡚␗࡞ࡿ㐠ືྖ௧ࡀ⬚㒊⚄⤒⠇࡟㏦
ሷỈ࡟ཱྀࢆࡘࡅࡿ࡜ࠊ┤ࡕ࡟ᚋࡎࡉࡾࡋ࡚ᐜჾ࠿
ࡽࢀ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡿࠋ
ࡽ㞳ࢀࡓࠋほᐹカ⦎ࡢ๓ᚋ࡛ほᐹ⪅ࢥ࢜ࣟࢠࡢ㸰Ⓨ⾲ㄽᩥ1) Hommaru, N., Shidara, H. Ando, N and Ogawa, H.

ࡘࡢໝ࠸ࡢ┦ᑐⓗ࡞Ⴔዲᛶࢆࢸࢫࢺࡋࠊໝ࠸Ⴔዲ
ᛶ࡟ኚ໬ࡀ࠶ࡿ࠿ࢆㄪ࡭ࡓ⤖ᯝࠊほᐹ⪅ࢥ࢜ࣟࢠࢹࣔࣥࢫࢺ࣮ࣞࢱࢥ࢜ࣟࢠࡀ㛗᫬㛫⁫ᅾࡋỈࢆ㣧
− 13 −

ࢇࡔỈ※ࡢໝ࠸࡬ࡢႴዲᛶࡣࠊカ⦎ᚋ࡟ࡣカ⦎๓ࡼࡾࡶ᭷ព࡟㧗ࡃ࡞ࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋ୍᪉ࠊࢹ
ࣔࣥࢫࢺ࣮ࣞࢱ࡜ࡋ࡚Ṛࢇࡔࢥ࢜ࣟࢠࢆỈ※࡟⨨ࡃ࡜ࠊほᐹ⪅ࢥ࢜ࣟࢠࡢࡑࡢỈ※ࡢໝ࠸࡬ࡢႴዲᛶࡣࠊカ⦎ᚋ࡟ࡣカ⦎๓ࡼࡾࡶ᭷ព࡟పࡃ࡞ࡗࡓࠋ
ࡇࢀࡽࡢ♫఍Ꮫ⩦࡟㛵ࢃࡿ㐃ྜ㐣⛬࡟ࡘ࠸࡚♧၀ࢆᚓࡿ┠ⓗ࡛ࠊᏛ⩦ᚋ࡟Ỉࢆ༑ศ࡟㣧ࡲࡏࠊỈࡢሗ㓘࡜ࡋ࡚ࡢ౯್ᘬࡁୗࡆࡓ≧ែ࡛ໝ࠸Ⴔዲᛶ
ࢸࢫࢺࢆ⾜࠺⾜ືᐇ㦂࡞࡝ࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊ⏕ࡁࡓࢹࣔࣥࢫࢺ࣮ࣞࢱ࡟ࡼࡾႴዲᛶࡢ♫఍Ꮫ⩦ࡣỈ㸦↓᮲௳่⃭㸧࡜௚ಶయ㸦᮲௳่⃭ 1㸧࡜ໝ࠸(᮲௳่⃭ 2)ࡀ⤖ࡧࡘࡃ㸰ḟ᮲௳௜ࡅ࡟ࡼࡗ࡚
㉳ࡇࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ୍᪉௚ࡢᐇ㦂⤖ᯝ࠿ࡽࠊṚࢇࡔࢹࣔࣥࢫࢺ࣮ࣞࢱ࡟ࡼࡿᚷ㑊ᛶ♫఍Ꮫ⩦ࡣࠊໝ࠸ࡢ᮲௳่⃭࡜Ṛయࡢ↓᮲௳่⃭ࡀ⤖ࡧࡘࡃ㸯ḟ᮲௳௜ࡅ࡟ࡼࡗ࡚㉳ࡇࡿ࡜♧၀ࡉࢀࡓࠋ
ࡇࢀࡽࡢ௬ㄝࡢ᳨ドࡀḟࡢㄢ㢟࡜࡞ࡿࡀࠊࡑࡢ᳨ドࡢࡓࡵ࡟ࡣሗ㓘᝟ሗࡸ⨩᝟ሗࢆఏ࠼ࡿ࢜ࢡࢺ
ࣃ࣑ࣥࢽ࣮ࣗࣟࣥࡸࢻ࣮ࣃ࣑ࣥࢽ࣮ࣗࣟࣥࡢཷᐜ
య㜼ᐖ๣ࢆ⏝࠸ࡓ⸆⌮ᐇ㦂ࡀᚲせ࡛࠶ࡿࠋࡇࢀࡲ
࡛ࡢᐇ㦂⣔࡛ࡣࡑࡢࡼ࠺࡞ᐇ㦂ࡣ㠀ᖖ࡟ᅔ㞴࡛࠶ࡿࡢ࡛ࠊ᪂ࡓ࡟ᐇ㦂᪉ἲࡢᨵⰋࢆ㐍ࡵࡓࠋࡑࡢ⤖ᯝࠊ⸆⌮ᐇ㦂ࡢࡓࡵࡢᐇ㦂⣔ࢆ࡯ࡰ☜❧ࡋࡘࡘ࠶ࡿࠋཎⴭㄽᩥ1) Ebina H., Mizunami M. (2020). Appetitive andaversive social learning with living and deadconspecifics in crickets. Sci, Rep. 10:9340.

ࢆྠᐃࡋࡓࡀࠊ௒ᖺ࡟ධࡗ࡚⡿ᅜࡢ Hsd:ICR ࡢ࢚ࢡࢯ࣮࣒ࢩ࣮ࢡ࢚ࣥࢫゎᯒࡀࢹ࣮ࢱ࣮࣋ࢫୖ࡟Ⓩ
㘓ࡉࢀࡓࡇ࡜࠿ࡽࠊ᪥ᮏࡢ ICR ࡟⏤᮶ࡍࡿᮏ⣔⤫࡜ẚ㍑ࡋࡓࠋ263 ಶࡢ indel ࡢ࠺ࡕ 182 ಶ㸦68.2%㸧
ࡢ indel ࡀṇᖖ࡞ Hsd:ICR ࡟ࡶᏑᅾࡋࠊࡑࢀࡽࡣೃ
⿵ኚ␗࠿ࡽ㝖እࡉࢀࡓࠋࡇࡢ 182 ಶࡢ indel ࡣ
dbSNP ࢹ࣮ࢱ࣮࣋ࢫ࡟Ⓩ㘓ࡉࢀ࡚࠾ࡽࡎࠊICR ⣔⤫࡟ࣘࢽ࣮ࢡ࡞ indel ࡔ࡜ุ᩿ࡉࢀࡓࠊࡑࡢከࡃࡣࠊ
ᢠయ㑇ఏᏊࡸႥぬཷᐜయ㑇ఏᏊ➼ࡢከ㔜㑇ఏᏊ࡟Ꮡᅾࡍࡿ࠿ࠊindel ࡀ᭱⤊࢚ࢡࢯࣥ࡟Ꮡᅾࡋࡓࠋ
⥆࠸࡚࣑ࢫࢭࣥࢫኚ␗ࢆྠᐃࡍࡿࡓࡵࠊGATKࣃࢵࢣ࣮ࢪࢆ⏝࠸࡚ C57BL/6J ࡜ࡢ㛫ࡢኚ␗ࢆࢥ
࣮ࣝࠊ᪤࡟ dbSNP ࢹ࣮ࢱ࣮࣋ࢫ࡟Ⓩ㘓ࡉࢀ࡚࠸ࡿ
ኚ␗ࢆ㝖እࡋࡓ࡜ࡇࢁࠊ719 ಶࡢ⩻ヂ㡿ᇦෆࡢ࣑ࢫࢭࣥࢫኚ␗ࡀ᳨ฟࡉࢀࡓࠋୖグ࡜ྠᵝ࡞⤠ࡾ㎸ࡳࢆᐇ᪋ࡋࡓ࡜ࡇࢁࠊ346 ಶ㸦48.1%㸧ࡢ࣑ࢫࢭࣥ
ࢫኚ␗ࡀ Hsd:ICR ࢤࣀ࣒࡟ࡶㄆࡵࡽࢀࡇ࡜࠿ࡽೃ
⿵࠿ࡽ㝖እࡉࢀࠊࡉࡽ࡟ 21 ᪥㱋ࡢ⢭ᕢ࡛㧗Ⓨ⌧ࡍࡿ㑇ఏᏊࢆᣦᶆ࡟ࡋࡓ࡜ࡇࢁࠊ᭱⤊ⓗ࡟ 7 ಶࡢೃ⿵㑇ఏᏊࡢ⤠ࡾ㎸ࡳ࡟ᡂຌࡋࡓࠋࡑࢀࡽೃ⿵㑇ఏᏊࡢࢤࣀ࣒⦅㞟ࢆ㛤ጞࡋࡓࠋ ᮏ◊✲ࡢ๪⏘≀࡜ࡋ࡚ࠊᐇ㦂ື≀࡜ࡋ࡚ࡼࡃ⏝࠸ࡽࢀࡿ ICR ⣔⤫ࡢ☜❧࣭ศ୚ࡉࢀ࡚⤒⦋ࡢ᝟ሗࡀᚓࡽࢀࡓࠋࡍ࡞ࢃࡕࠊࡲࡎࢡ࣮ࣟࢬࢻࢥࣟࢽ࣮
⣔࡜ࡋ࡚ ICR ࡀ☜❧ࡉࢀ࡚ࠊࡑࡢᚋ࡟᪥⡿Ḣ࡟ศ㓄ࡉࢀࡓ⤒⦋ࡀ᥎ ࡉࢀࡓࡇ࡜ࡣࠊ⯆࿡῝࠸ࠋ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศศ㔝⏕≀⛉Ꮫ㒊࿴ከ ࿴ᏹⴭ᭩1) ỈἼㄔ(2020)ࠊ ື≀ࡢ஦඾ࠊᮎᯇ௚⦅ࠕឤぬჾࠖࢆᢸᙜࠊᮅ಴᭩ᗑ

◊✲⤖ᯝ㡢ኌⓎኌᏛ⩦ࡢ⮫⏺ᮇไᚚཬࡧࠊ✀≉␗ⓗ࡞Ⓨኌࣃࢱ࣮ࣥ⏕ᡂ࡟㛵ࢃࡿ㑇ఏᏊ⩌ࢆ᫂ࡽ࠿࡟ࡋࠊ
ࡑࡢ⬻ෆศᏊᶵ⬟ࢆ⚄⤒⾜ືᏛⓗ࡟᳨ドࡍࡿࡇ࡜㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศศ㔝⏕≀⛉Ꮫ㒊ࢆ┠ⓗ࡜ࡋ࡚◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋࣄࢺࡢゝㄒࡸᑠ໭⏣ ୍༤
㫽ࡢḷࡣࠊぶ࡞࡝௚ಶయࡢⓎኌࣃࢱ࣮ࣥࢆࡲࡡࡿ
ࡇ࡜࡛ᚋኳⓗ࡟⋓ᚓࡉࢀࡿࠋࡇࡢⓎኌᏛ⩦࡟ࡣࠊ ࣄࢺࢤࣀ࣒࡟ࡣ 2 ୓ಶ⛬ᗘࡢ㑇ఏᏊࡀᏑᅾࡍࡿ
Ꮫ⩦ࡀຠ⋡ࡼࡃ㐍ࡴ᫬ᮇࠊࡍ࡞ࢃࡕᏛ⩦⮫⏺ᮇ㸦ឤࡀࠊࡑࡢ࠺ࡕ⣙ 2,000 ಶࡢ㑇ఏᏊࡀ⢭Ꮚᙧᡂ࡟㛵ཷᛶᮇ㸧ࡀ࠶ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋⓎኌᏛ⩦ࢆ୚ ࡍ ࡿ ࡜ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ 㸦 Csilla Krausz,et. al,ྵࡴឤぬ㐠ືᏛ⩦ࡣࠊື≀⮬ࡽ⾜ື⏕ᡂࡍࡿࡇ࡜Nature Review Urology, 2018㸧ࠋࡋ࠿ࡋࠊࡑࡢከࡃࡣ
࡛⋓ᚓࡉࢀࡿᏛ⩦ᵝᘧ࡛࠶ࡿࠋࡑࡢ⮬Ⓨⓗ⾜ື࡟ᶵ⬟ゎᯒࡀ㐍ࢇ࡛࠾ࡽࡎࠊ୙ዷ⑕ࡢ⑓ᅉ࣭⑓ែࢆ
ࡼࡾ⬻ෆ࡛ࡣ࢚ࣆࢪ࢙ࢿࢸ࢕ࢡࢫไᚚᅉᏊࢆྵࡴ
ゎ᫂ࡍࡿ࠺࠼࡛㞀ᐖ࡜࡞ࡗ࡚࠸ࡿࠋ᫖ᖺࠊ๗᳨࡟
㑇ఏᏊ⩌ࡀ⚄⤒άື౫Ꮡⓗ࡟Ⓨ⌧ㄏᑟࡉࢀࠊ⚄⤒࡚ ICR ࣐࢘ࢫࡢྠ୍ࣜࢵࢱ࣮ෆ࡛ࠊ㞝࡟࠾࠸࡚⢭ྍረᛶ࡞࡝ࡢ⚄⤒ᅇ㊰ࡢᶵ⬟≉ᛶࡢኚ໬ࡀ㉳ࡇࡿࠋᕢⴎ⦰ࢆ♧ࡍ」ᩘࡢಶయࢆഅ↛࡟ぢฟࡋࡓࠋ⑓⌮ࡋ࠿ࡋࠊከࡃࡢᏛ⩦⾜ືࡀࠊࠕ࠸ࡘ࣭࡝ࡢࡼ࠺࡟࣭
⤌⧊Ꮫⓗ᳨⣴࡛ࡣ෇ᙧ⢭Ꮚ⣽⬊ࡢ⵳✚࡜ᕧ኱ከ᰾
࡝ࢀࡔࡅࠖ⏕ᡂࡉࢀࡿ࠿ࡣࠊື≀ಶయࡈ࡜࡟኱ࡁ
⣽⬊ࡢฟ⌧ࡀほᐹࡉࢀࠊ➨୍ῶᩘศ⿣ᮇࡢᰁⰍయ
࡞㐪࠸ࡀ⏕ࡌࡿࠋࡇࡢ⾜ື⏕ᡂࡢ᫬ᮇ࣭㉁࣭㔞ࡢศ㓄࡟ఱࡽ࠿ࡢ␗ᖖࢆ࿊ࡋ࡚࠸ࡿࡇ࡜ࡀ᥎ᐹࡉࢀ
㐪࠸ࢆࠕಶయࡢᏛ⩦⾜ືᒚṔࠖ࡜ࡋ࡚ࠊ⬻ෆ࡛ࣔࡓࠋ௒ᖺᗘ࡟࠾࠸࡚ࡣ᫖ᖺᗘ࡟ᘬࡁ⥆ࡁࠊ␗ᖖಶ
ࢽࢱ࣮ࡋࠊಶయࡈ࡜࡟ࣘࢽ࣮ࢡ࡞⬻ෆ㑇ఏᏊⓎ⌧య࡟⏤᮶ࡍࡿࢤࣀ࣒ DNA ࡢ Reseq ゎᯒࢆ⥅⥆ࡋࡓࠋ࡟㑏ඖࡍࡿ⚄⤒ศᏊ࣓࢝ࢽࢬ࣒ࡀᏑᅾࡍࡿ࡜⪃࠼᫖ᖺࡲ࡛ࡣࠊ⩻ヂ㡿ᇦ࡟Ꮡᅾࡍࡿ 263 ಶࡢ indelࡽࢀࡿࠋᮏ◊✲࡛ࡣࠊ㬆⚺㢮ࢯࣥࢢࣂ࣮ࢻࡢⓎኌ− 14 −

Ꮫ⩦ࢆᏛ⩦⾜ືࣔࢹࣝ࡜ࡋ࡚ࠊ
ࠕ⮬ࡽኌࢆฟࡍࠖ࡜
࠸࠺⮬Ⓨⓗ⾜ືࡀࠊࡑࡢᚋ࡟⋓ᚓࡉࢀࡿ㡢ኌࣃࢱ࣮ࣥࡸᏛ⩦⮫⏺ᮇ㛫ࡢಶయᕪ࡟࡝ࡢࡼ࠺࡞ᙳ㡪ࢆ୚࠼ࡿࡢ࠿ࠊ⮬ⓎᏛ⩦⾜ື౫Ꮡⓗ࢚ࣆࢪ࢙ࢿࢸ࢕
ࢡࢫไᚚࡢほⅬ࠿ࡽ◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋࡑࡢࡓࡵࠊ
ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛࡛㣫⫱࣭⦾Ṫࡋࡓື≀ಶయࢆ⏝࠸࡚ࠊ⚄⤒⾜ືᏛⓗ◊✲ࢆᐇ᪋ࡋ࡚࠸ࡿࠋ
௒ᖺᗘࡣࠊⓎኌᏛ⩦⮫⏺ᮇ࡛ࡢ࢚ࣆࢪ࢙ࢿࢸ࢕
ࢡࢫືែࢆ᫂ࡽ࠿࡟ࡍࡿ┠ⓗ࡛ࠊḷ⚄⤒᰾࡛ࡢ࣮࢜ࣉࣥࢡ࣐ࣟࢳࣥ㡿ᇦࡢᏛ⩦⮫⏺ᮇ๓ᚋࡢኚ໬ࢆ᳨ドࡋࡓࠋࡑࡢ⤖ᯝࠊ㐠ື⣔ḷ⚄⤒᰾࡟࠾࠸࡚ࠊ
ATAC-seq ࢩࢢࢼࣝ࡜ࡋ᳨࡚ฟࡉࢀࡿ࣮࢜ࣉࣥࢡ
࣐ࣟࢳࣥ㡿ᇦࡢࣆ࣮ࢡࡢ኱ࡁࡉࡀࠊྠࡌ᪥㱋࡟ࡶ㛵ࢃࡽࡎࠊྠ✀ಶయ㛫࡛␗࡞ࡿ࡜࠸࠺࣮ࠗ࢜ࣉࣥ
ࢡ࣐ࣟࢳࣥ㡿ᇦࡢಶయᕪ࠘ࡢᏑᅾࢆⓎぢࡋࡓࠋࡉࡽ࡟ࠊࡇࡢಶయᕪࢆ♧ࡍ࣮࢜ࣉࣥࢡ࣐ࣟࢳࣥ㡿ᇦෆ࡟ࡣಶయ㛫 SNPs ࡀ㧗࠸㢖ᗘ࡛Ꮡᅾࡍࡿࡇ࡜࡟
Ẽࡀ௜࠸ࡓࠋᐇ㝿ࠊࡇࡢ ATAC ࣆ࣮ࢡࡢಶయᕪ࡟
ᑐᛂࡍࡿࡼ࠺࡟ࠊ ⣙ 15㹼20%ࡢ๭ྜ࡛ࠊ㏆ഐ࡟Ꮡᅾࡍࡿ㑇ఏᏊࡢ㌿෗Ⓨ⌧ࣞ࣋ࣝ࡟ಶయᕪࡀ⏕ࡌ࡚࠸ࡿࡇ࡜ࡶ᫂ࡽ࠿࡟࡞ࡗࡓࠋ
ㄽᩥⓎ⾲
James LS, Davies R Jr, Mori C, Wada K, Sakata JT.
(2020) Manipulations of Sensory Experiences During
Development Reveal Mechanisms Underlying Vocal
Learning Biases in Zebra Finches. Developmental
Neurobiology 80:132-146.
James LS, Sun H, Wada K, Sakata JT. (2020)
Statistical learning for vocal sequence acquisition in a
songbird. Scientific Reports 10:2248.
⏕≀⛉Ꮫ㒊㒊㛛 ⏕ṪⓎ⏕⏕≀ᏛᏛศ㔝㯮ᒾ 㯞㔛
⚾ࡓࡕࡀ◊✲ᑐ㇟࡜ࡋ࡚࠸ࡿ࢔࣐࣑ࢺࢤࢿࢬ࣑
(Tokudaia osimensis) ࡜ ࢜ ࢟ ࢼ ࣡ ࢺ ࢤ ࢿ ࢬ ࣑(Tokudaia muenninki) ࡣࠊࡑࡢᛶᰁⰍయ࡜ᛶỴᐃࡢศᏊ࣓࢝ࢽࢬ࣒࡟ࣘࢽ࣮ࢡ࡞≉ᚩࢆࡶࡘࠋࡑࡇ࡛ࠊ
ࢺࢤࢿࢬ࣑ᒓࡢᛶᰁⰍయ㐍໬ࡢ㐣⛬࠾ࡼࡧᛶỴᐃศᏊ࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚ࠊ㸰✀ࡢ෾⤖⥺⥔ⱆ⣽⬊ࢆᮏࢭࣥࢱ࣮すᲷ࡟࡚ಖ⟶ࡋ࡚࠸ࡿࠋࡲࡓࠊ㸰✀ࡢ BAC ࣛ࢖ࣈ࣮ࣛࣜࢆస〇ࡋࠊྠࡌࡃすᲷ࡟࡚ಖ⟶ࡋ࡚࠸ࡿࠋಖ⟶ࡋ࡚࠸ࡿ
BAC ࣛ࢖ࣈ࣮ࣛࣜࡣࠊ࢔࣐࣑ࢺࢤࢿࢬ࣑ࡀ 384 ࢙࢘ࣝࣉ࣮ࣞࢺ 255 ᯛࠊ࢜࢟ࢼ࣡ࢺࢤࢿࢬ࣑ࡀ 384
࢙࢘ࣝࣉ࣮ࣞࢺ 420 ᯛ࡛࠶ࡿࠋࡇࢀࡽࡢ BAC ࣛ࢖ࣈ࣮ࣛࣜࡣ⊂❧⾜ᨻἲே ⌮໬Ꮫ◊✲ᡤ ච␿࣭࢔ࣞࣝࢠ࣮⛉Ꮫ ⥲ྜ◊✲ࢭࣥࢱ࣮㸦⚄ዉᕝ┴ᶓ὾ᕷ㸧࡛సᡂࠊಖᏑࡉࢀ࡚࠸ࡓࡶࡢ࡛࠶ࡿࠋᕼᑡ࡞
ࢧࣥࣉࣝࢆ᪥ᮏྛᆅ࡟ศᩓࡉࡏࠊ⅏ᐖ᫬ࡢᦆኻࢆ

᭱ᑠ㝈࡟ᢚ࠼ࡿ┠ⓗ࠿ࡽࡶࠊᙜࢭࣥࢱ࣮࡟࡚ಖ⟶ࡋ࡚࠸ࡿࠋ ࢔࣐࣑ࢺࢤࢿࢬ࣑ࡣ့ங㢮࡛࠶ࡾ࡞ࡀࡽ Y ᰁⰍయࢆᾘኻࡋ࡚࠾ࡾࠊ㞤㞝࡜ࡶ࡟ XO ᆺ (2n=25,
XO/XO) ࡜࠸࠺኱ኚ⌋ࡋ࠸᰾ᆺࢆࡶࡘࠋࡲࡓ့ங㢮 ࡢ ᛶ Ỵ ᐃ 㑇 ఏ Ꮚ ࡛ ࠶ ࡿ SRY (sex determining
region on Y) 㑇ఏᏊࡶᾘኻࡋ࡚࠸ࡿࠋࡋ࠿ࡋࠊ୍㒊ࡢ Y ᰁⰍయࡢ㑇ఏᏊࡣࠊX ᰁⰍయ㛗⭎ᮎ➃㒊࡟㌿ᗙࡍࡿࡇ࡜࡛ࠊ⌧ᅾࡶṧࡉࢀ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡗ
࡚࠸ࡿࠋᮏᖺᗘࡣࠊࡇࢀࡽ Y 㑇ఏᏊ㓄ิࢆ฼⏝ࡋ
࡚ BAC ࢛࣮࢘࢟ࣥࢢࢆ⾜࠸ࠊX ᰁⰍయୖ࡟ṧࡉࢀ࡚࠸ࡿඖ Y ᰁⰍయ㡿ᇦࡢ඲㓄ิ࡜ඖ Y 㑇ఏᏊ࡟ࡘ࠸࡚᫂ࡽ࠿࡟ࡋࡓࠋ ࡲࡓࠊ㫽㢮࡟࠾ࡅࡿ⏕ṪⓎ⏕Ꮫ◊✲ࢆᒎ㛤ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚ࠊࢤࣀ࣒ᮾᲷ࡛ࢽ࣍ࣥ࢘ࢬࣛ
(Coturnix japonica) ࢆ㣫⫱ࡋ࡚࠸ࡿࠋᮏᖺᗘࡣࠊᮏ
✀࡟࠾ࡅࡿᛶỴᐃ࠾ࡼࡧᛶศ໬㛵㐃㑇ఏᏊࡢྠᐃࠊ
ྛ㑇ఏᏊࡢⓎ⌧ᵝᘧࡢ☜ㄆࢆ⾜ࡗࡓࠋࡲࡓࠊ」ᩘ
ࡢⓎ⏕ẁ㝵࡟࠶ࡿึᮇ⏕Ṫ⭢࡟࠾࠸࡚ RNA-seq ゎᯒࢆᐇ᪋ࡋࠊᚓࡽࢀࡓࢹ࣮ࢱࢆ㞤㞝㛫࡛ẚ㍑ࡋࠊ
Ⓨ⌧ᵝᘧࡢࣉࣟࣇ࢓࢖ࣜࣥࢢࢆ⾜࡞ࡗࡓࠋࡑࡢ⤖ᯝࠊᛶศ໬㛵㐃㑇ఏᏊࡣඹ㏻ࡢⓎ⌧ࣃࢱ࣮ࣥࢆ࡜
ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ ࡉࡽ࡟ࠊୖ㏙ࡢ㫽㢮◊✲࡜୪⾜ࡋ࡚ࠊCRISPR/Cas9ࢩࢫࢸ࣒ࢆ฼⏝ࡋࡓࢤࣀ࣒⦅㞟ࢽ࣍ࣥ࢘ࢬࣛࡢస
ฟࡶᡭࡀࡅࡓࠋ⣽⬊࿘ᮇ G1 㛵㐃ࢱࣥࣃࢡ㉁࡛࠶ࡿ
ࢧ࢖ࢡࣜࣥ D1 ࢆࢥ࣮ࢻࡍࡿ㑇ఏᏊୖ࡟ gRNA ࢱ࣮ࢤࢵࢺ㓄ิࢆ㑅ᐃࡋࠊ㢧ᚤᤵ⢭ἲࢆ㥑౑ࡋ࡚సฟࡋࡓ 1 ⣽⬊ᮇࡢཷ⢭༸࡟ࡑࡢ sgRNA ࠾ࡼࡧ Cas9mRNA ࢆᢞ୚ࡋࡓࠋࡑࡢᚋࡢ⾲⌧ᆺゎᯒ࠿ࡽࠊ࡯
ࡰ඲࡚ࡢ⬇ࡀࢫࢸ࣮ࢪ V ࡜࿧ࡤࢀࡿ༸๭ᮇ࡛Ⓨ⏕೵Ṇࢆ࿊ࡍࡿࡇ࡜ࡀศ࠿ࡗࡓࠋࡉࡽ࡞ࡿࣉࣟࢸ࢜
࣮࣒ゎᯒ࠿ࡽࠊࢫࢸ࣮ࢪ V ௨㝆ࡢⓎ⏕࡟ᚲせ୙ྍḞ࡛࠶ࡿ retinoblastoma ࢱࣥࣃࢡ㉁ࡢศゎ࡟ࢧ࢖ࢡࣜࣥ D1 ࡀ㛵୚ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
ㄽᩥⓎ⾲࣭Ꮫ఍Ⓨ⾲➼
1. Okuno M*, Miyamoto M*, Itoh T, Seki M, Suzuki Y,
Mizushima S, Kuroiwa A. (2020) Expression
profiling of sexually dimorphic genes in the Japanesequail, Coturnix japonica 㸬 Scientific Reports
10:20073. *Equally contribution.
2. Matsuzaki M, Hirohashi N, Tsudzuki M, Haqani MI,
Maeda T, Mizushima S, Sasanami T. (2021) Longer
and faster sperm exhibit better fertilization successin Japanese quail. Poultry Science 100:100980.
3. Matsuzaki M, Hirohashi N, Mizushima S, Sasanami
T. (2021) Effect of sperm surface oligosaccharides insperm passage into sperm storage tubules in Japanesequail (Coturnix japonica). Animal Reproduction
Science in press.
4. Kuroiwa A: Unique genome evolution of the− 15 −

Y-absent mammal in genus Tokudaia. The workshop"Biological fate determination by multidimensional
genome changes", The 43rd Annual Meeting of the
Molecular Biology Society of Japan. Organizer and
Presenter: Kuroiwa A, 3rd Dec, 2020, Online.
5. 㯮ᒾ㯞㔛: Y ᰁⰍయ࡜ SRY 㑇ఏᏊࢆࡶࡓ࡞࠸့
ங㢮✀ࡢᛶỴᐃ࣓࢝ࢽࢬ࣒໬㸦ᣍᚅㅮ₇㸧㸪➨
92 ᅇ᪥ᮏ㑇ఏᏛ఍ᖺ఍㸪࣮࣡ࢡࢩࣙࢵࣉࠕ࣐࢘
ࢫ㑇ఏᏛ࠿ࡽࡳࡿࢡ࣐ࣟࢳࣥไᚚᶵᵓࠖ㸪2020
ᖺ 9 ᭶ 18 ᪥㸪ࡃࡲࡶ࡜┴Ẹ஺ὶ㤋ࣃࣞ࢔㸪⇃ᮏ㸬
6. Ỉᓥ⚽ᡂ, 㯮ᒾ㯞㔛: ࢘ࢬࣛ⬇ࡢẕᛶ-⬇ᛶ㑄⛣ᮇ࡟࠾ࡅࡿࢧ࢖ࢡࣜࣥ D ࡢᙺ๭, ➨ 6 ᅇ໭኱࣭㒊ᒁᶓ᩿ࢩ࣏ࣥࢪ࣒࢘, 2020 ᖺ 10 ᭶ 19 ᪥, ࢜ࣥࣛ࢖ࣥ㛤ദ.
7. Ỉᓥ⚽ᡂ: 㫽㢮ከ⢭ཷ⢭࡟࠾ࡅࡿ୺⢭Ꮚ㑅ᢥ࡜వ๫⢭Ꮚ᤼㝖࣓࢝ࢽࢬ࣒࡟㛵ࡍࡿ◊✲, ➨ 21ᅇ᪥ᮏ␆⏘Ꮫ఍ⱝᡭ௻⏬ࢩ࣏ࣥࢪ࣒࢘, 2020 ᖺ
11 ᭶ 13 ᪥, ࢜ࣥࣛ࢖ࣥ㛤ദ.
8. Ỉᓥ⚽ᡂ, ሯ⏣ග, ➲ᾉ▱ᏹ, ᑠ㔝⌔எ, 㯮ᒾ㯞㔛: ࢘ࢬࣛึᮇ⬇࡟࠾ࡅࡿ DAZL (deleted inazoospermia-like) ࡢⓎ⌧ゎᯒ, ➨ 44 ᅇ㫽㢮ෆศἪ◊✲఍, 2020 ᖺ 12 ᭶ 12 ᪥, ࢜ࣥࣛ࢖ࣥ㛤ദ.
9. ᕷᕝెఙ, ᯇᓮⱆ⾰, Ỉᓥ⚽ᡂ, ➲ᾉ▱ᏹ: ࢘ࢬࣛࡢ⢭Ꮚ-༸Ꮚ┦஫స⏝࡟࠾ࡅࡿ Annexin6 ࡢᙺ๭, ᪥ᮏᐙ⚺Ꮫ఍ 2021 ᖺᗘ᫓Ꮨ኱఍, 2021 ᖺ
3 ᭶ 27 ᪥, ࢜ࣥࣛ࢖ࣥ㛤ദணᐃ.
10. ᯇᓮⱆ⾰, Ỉᓥ⚽ᡂ, ᗈᶫᩍ㈗, ᇼෆᾈᖾ, ➲ᾉ▱ᏹ: ࢘ࢬࣛࡢ⢭Ꮚ⾲㠃ࡢ⢾㙐ࡀ⢭Ꮚ㈓ⶶ
⟶࡬ࡢ⢭Ꮚ౵ධ࡬ᯝࡓࡍᙺ๭, ᪥ᮏᐙ⚺Ꮫ఍
2021 ᖺᗘ᫓Ꮨ኱఍, 2021 ᖺ 3 ᭶ 27 ᪥, ࢜ࣥࣛ࢖ࣥ㛤ദணᐃ.
㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫ
Ꮫศ㔝
⏕≀⛉Ꮫ㒊
Ⲷཎ ඞ┈⬨᳝ື≀ࡢ⏕Ṫჾᐁࡢᶵ⬟࡟㛵ࡍࡿ◊✲㸦◊✲┠ⓗ㸧⬨᳝ື≀ࡢ⏕Ṫάືࡣ㸪どᗋୗ㒊㸦⬻㸧㸫⬻ୗᆶయ㸫⏕Ṫ⭢࠿ࡽ࡞ࡿ⏕ṪෆศἪ⣔࡟ࡼࡾㄪ⠇ࡉࢀ㸪༸ᕢ࡛ࡘࡃࡽࢀࡿ༸࡜⢭ᕢ࡛ࡘࡃࡽࢀ
ࡿ⢭Ꮚࡢྜయ㸦ཷ⢭㸧࡟ࡼࡾ᪂ࡋ࠸ಶయࡀ࡛ࡁࡿࠋ
ᙜ◊✲ᐊ࡛ࡣ㸪༸ᕢ㸪⢭ᕢ➼࡟࠾ࡅࡿᵝࠎ࡞⌧㇟ࢆศᏊ࡛ࣞ࣋ࣝゎᯒࡋࠊࡑࡢ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜ࢆ┠ⓗ࡟◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋ⌧ᅾࡣࠊ⬨᳝ື≀ࡢ༸ᕢᶵ⬟㸦≉࡟༸Ꮚᙧᡂࡸ᤼༸㸧࡟㛵㐃ࡍࡿᮍゎ᫂࡞ㄢ㢟࡟ྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ
㸦⤒㐣࣭⤖ᯝ㸧 ᙜ◊✲ᐊ࡛ࡣ㸪ᐇ㦂ᮦᩱ࡜ࡋ࡚࣓ࢲ࢝ࡸ࣐࢘ࢫ
ࢆ⏝࠸࡚◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ࣓ࢲ࢝ࡣࠊ᤼༸ᐇ⾜࡟ᚲせ୙ྍḞ࡞㓝⣲㸦᤼༸㓝⣲㸧ࡀࡍ࡛࡟ྠᐃࡉ
ࢀ࡚࠾ࡾࠊࡉࡽ࡟⏕యእ࡛᤼༸⌧㇟ࢆほᐹ࡛ࡁࡿᇵ㣴⣔ࡀ฼⏝ྍ⬟࡞ࡇ࡜࠿ࡽࠊ᤼༸◊✲࡟㐺ࡋࡓᐇ㦂ື≀࡛࠶ࡿࠋ࣓ࢲ࢝ࢆ⏝࠸ࡓ᤼༸㛵㐃◊✲࡜ࡋ࡚௨ୗࡢ 2 ࢸ࣮࣐࡟ࡘ࠸࡚◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ
ࡲࡓࠊ࣐࢘ࢫࢆ⏝࠸ࡓ◊✲ࢸ࣮࣐࡜ࡋ࡚௨ୗࡢ◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ
㸦1㸧᤼༸㛵㐃㑇ఏᏊḞᦆ࣓ࢲ࢝ࡢస〇࣓ࢲ࢝᤼༸࡟㔜せ࡞ᙺ๭ࢆᢸ࠺ࡇ࡜ࡀุ᫂ࡋ࡚
࠸ࡿ MT2-MMP ࡣࠊ᤼༸ࡢ┤๓࡟ᛴ⃭࡟ㄏᑟࡉࢀ
ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗ࡚࠸ࡿࠋࡲࡓࠊ᰾ෆࣉࣟࢤ
ࢫࢳࣥཷᐜయ(nPR)ࡣ㯤యᙧᡂ࣍ࣝࣔࣥ LH ࡟ࡼࡾㄏᑟࡉࢀࠊMT2-MMP ࢆྵࡴᵝࠎ࡞᤼༸㛵㐃㑇ఏ
ᏊࡢⓎ⌧ㄏᑟ࡟㛵୚ࡍࡿ᰾ෆ㌿෗ᅉᏊ࡜ࡋ࡚ᶵ⬟ࡍࡿࡇ࡜ࡀᙜ◊✲ᐊࡢ◊✲࠿ࡽ᫂ࡽ࠿࡜࡞ࡗ࡚࠸
ࡿࠋࡇࡢ◊✲ㄢ㢟ࡣࠊୖグ 2 ✀ࡢ᤼༸㛵㐃㑇ఏᏊ࡟ ࡘ ࠸ ࡚ CRISPR-Cas9 ࢩ ࢫ ࢸ ࣒ ࢆ ฼ ⏝ ࡋ
MT2-MMP ࠾ࡼࡧ nPR knockout ࣓ࢲ࢝ࢆసฟࠊゎᯒࢆ⾜࠺ࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚࠸ࡿࠋ
MT2-MMP Ḟᦆ࣓ࢲ࢝࡟ࡘ࠸࡚ࡣࠊࣇ࣮࣒ࣞࢩ
ࣇࢺ࡟ࡼࡾ㏵୰࡛⤊ጞࢥࢻࣥࡀධࡿኚ␗࣓ࢲ࢝ࡀ
2 ⣔⤫ᚓࡽࢀ࡚࠾ࡾࠊ1 ⣔⤫࡟ࡘ࠸࡚ࡣ࣓࣍ࣔࢲ࢝
ࡢసฟࡲ࡛⤊஢ࡋ࡚࠸ࡿࠋࡇࡢ⣔⤫ࡣࠊண᝿࡟཯
ࡋ࡚୙ዷࡢ⾲⌧ᆺࡣ♧ࡉࡎࠊṇᖖ࡟᤼༸ࡀ㉳ࡁࡿࡇ࡜ࡀ☜ㄆࡉࢀࡓࠋࡋ࠿ࡋ࡞ࡀࡽࠊ㔝⏕ᆺࡸ࣊ࢸ࣓ࣟࢲ࢝࡜ẚ㍑ࡋ࡚᤼༸ᩘࡀῶᑡࡍࡿഴྥࡀ☜ㄆࡉࢀࡓࡢ࡛ࠊ௒ᚋࡼࡾヲ⣽࡞ゎᯒࢆ⾜࠺ணᐃ࡛࠶
ࡿࠋࡲࡓࠊ⬇Ⓨ⏕᫬࡟ࡶ࠶ࡿ๭ྜ࡛␗ᖖࢆ᮶ࡍಶ
యࡀ☜ㄆࡉࢀ࡚࠾ࡾࠊࡇࢀ࡟ࡘ࠸࡚ࡶࡼࡾヲ⣽࡞ゎᯒࢆ㐍ࡵࡿணᐃ࡛࠶ࡿࠋ୍᪉ࠊnPR Ḟᦆ࣓ࢲ࢝࡟ࡘ࠸࡚ࡣࠊ୍㒊࢔࣑ࣀ㓟Ḟኻࡀ㉳ࡇࡿኚ␗ࡀᑟ
ධࡉࢀࡓኚ␗࣓ࢲ࢝ࡀ 2 ⣔⤫ࠊࣇ࣮࣒ࣞࢩࣇࢺ࡟
ࡼࡾ㏵୰࡛⤊ጞࢥࢻࣥࡀධࡿኚ␗࣓ࢲ࢝ࡀ 1 ⣔⤫ᚓࡽࢀ࡚࠸ࡿࠋࡑࡢ࠺ࡕࠊ࢔࣑ࣀ㓟Ḟኻ࣓ࢲ࢝㸯⣔⤫࡜ࣇ࣮࣒ࣞࢩࣇࢺ࣓ࢲ࢝㸯⣔⤫࡟ࡘ࠸࡚ࡣࠊ
࣓࣍ࣔࢲ࢝ࡢసฟࡲ࡛సฟࡀ㐍ࢇ࡛࠾ࡾࠊ௒ᚋヲ⣽࡞ゎᯒࢆ⾜࠺ணᐃ࡛࠶ࡿࠋ࡞࠾ࠊࡇࢀࡽࡢḞᦆ࣓ࢲ࢝࡟ࡘ࠸࡚ࡣࠊ↓᤼༸ࡢ⾲⌧ᆺࢆ♧ࡍಶయࡀ☜ㄆࡉࢀࡿ࡞࡝⯆࿡῝࠸⤖ᯝࡀᚓࡽࢀ࡚࠸ࡿࠋ
㸦2㸧࣓ࢲ࢝᤼༸ᚋࡢṧ␃ℐ⬊⤌⧊ࡢ㎿㏿ศゎᶵᵓ༸ẕ⣽⬊ࡣℐ⬊ෆ࡛ᡂ㛗ࡋࠊཷ⢭ྍ⬟࡞≧ែ࡟࡞ࡿ࡜᤼༸ࡉࢀࡿࠋℐ⬊ࡣ༸ẕ⣽⬊࡜༸ẕ⣽⬊ࢆ
ᅖࡴℐ⬊⣽⬊ᒙ࠿ࡽᡂࡾࠊ᤼༸᫬ࠊ༸ẕ⣽⬊ࡢࡳࡀ᤼༸ࡉࢀࠊ༸ᕢෆ࡟ࡣℐ⬊⣽⬊ᒙ(ℐ⬊⤌⧊)ࡀྲྀ
ࡾṧࡉࢀࡿࠋࡇࡢℐ⬊⤌⧊ࡣ୰ኸ㒊࡬࡜ᘬࡁ㎸ࡲࢀ࡞ࡀࡽࠊᚎࠎ࡟ศゎࡉࢀࠊ᭱⤊ⓗ࡟ᾘኻࡍࡿࡀࠊ
ẖ᪥᤼༸ࢆࡍࡿ࣓ࢲ࡛࢝ࡣࠊࡇࡢศゎࠊ㝖ཤᶵᵓࡀ့ங㢮࡞࡝࡜ẚ㍑ࡋ࡚ࠊࡎࡗ࡜᪩࠸ࠋᮏ◊✲ㄢ㢟࡛ࡣࠊࡇࡢ㎿㏿࡞ศゎࠊ㝖ཤᶵᵓࡢヲ⣽ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚࠸ࡿࠋ᤼༸ࡢ 16㹼20 ᫬㛫ᚋ࡟ℐ⬊⤌⧊ࡣ㝖ཤࡉࢀࡿࡀࠊࡇࡢ㝿ࠊ࢔࣏ࢺ࣮ࢩࢫࡀ㛵୚ࡍࡿࡇ࡜ࡀ♧၀ࡉࢀ࡚࠸ࡓࡇ࡜࠿ࡽࠊ
௒ᖺᗘࡣࡇࡢ࢔࣏ࢺ࣮ࢩࢫ࡟㛵୚ࡍࡿ caspase ࡟㛵ࡋ࡚ゎᯒࢆ⾜ࡗࡓࠋ− 16 −

 qRT-PCR ゎᯒࡢ⤖ᯝ࠿ࡽࠊ࣓ࢲ࢝༸ᕢ࡟ࡣࠊ5✀ࡢ caspase mRNA ࡢⓎ⌧ࡀ☜ㄆࡉࢀࠊࡇࡢ୰࡛Ⓨ⌧㔞ࡢ㧗࠸ 3 ✀࡟ࡘ࠸࡚ࠊࣜࢥࣥࣅࢼࣥࢺࢱࣥࣃ
ࢡ㉁ࢆస〇ࡋࠊࡇࢀࡽࢆᢠཎ࡜ࡋ࡚≉␗ⓗᢠయࡢస〇ࢆヨࡳࡓࠋࡑࡢ⤖ᯝࠊ3 ✀ࡍ࡭࡚࡟ࡘ࠸࡚≉␗ⓗᢠయࡀస〇࡛ࡁࡓࡢ࡛ࠊࡇࢀࡽࢆ⏝࠸࡚ࠊ༸ᕢෆ࡛ࡢࢱࣥࣃࢡ㉁Ⓨ⌧ࢆㄪ࡭ࡓࠋWestern blot ゎᯒ࠿ࡽࠊ1 ✀ࡢ caspase ࡟ࡘ࠸࡚ࡣࡑࡢⓎ⌧ࡀ☜ㄆ࡛ࡁࡓࡀࠊ௚ࡢ 2 ✀࡟ࡘ࠸࡚ࡣ᳨ฟ࡛ࡁ࡞࠿ࡗࡓࠋ
ࡇࡢ 2 ✀࡟ࡘ࠸࡚ࡣࠊ᳨ฟឤᗘ௨ୗࡢⓎ⌧㔞ࡶࡋࡃࡣⓎ⌧ࡋ࡚࠸࡞࠸ྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋ௒ᚋࡶ
ゎᯒࢆ⾜࠸ࠊ༸ᕢ࡟Ⓨ⌧ࡍࡿ caspase ࡢ≉ᐃࢆ㐍ࡵࡿࠋ
㸦3㸧ℐ⬊㑅ᢥᶵᵓࡢゎ့᫂ங㢮ࡢ༸ᕢ࡟ࡣࠊཎጞℐ⬊࡜ࡼࡤࢀࡿℐ⬊ࡀከᩘࢫࢺࢵࢡࡉࢀ࡚࠸ࡿࠋࡇࡢཎጞℐ⬊ࡢ୍㒊㸦ᩘ༑ಶ㹼ⓒಶ⛬ᗘ㸧ࡀఱࡽ࠿ࡢ่⃭࡟ࡼࡾᡂ㛗ࢆ㛤ጞࡋࠊ᭱⤊ⓗ࡟㸯㹼10 ಶ⛬ᗘࡢ༸Ꮚࡀ᤼༸ࡉࢀࡿࠋ
ᡂ㛗ࢆ㛤ጞࡋࡓℐ⬊ࡢ኱㒊ศࡣࠊ㏵୰࡛ᡂ㛗ࢆ೵Ṇࡋࠊ࢔࣏ࢺ࣮ࢩࢫ࡟ࡼࡾṚ⁛ࡍࡿࠋࡇࡢ㐣⛬ࡀ
ℐ⬊㑅ᢥ࡛࠶ࡿࡀࠊ⏕ࡁṧࡿℐ⬊࡜࢔࣏ࢺ࣮ࢩࢫ
࡟ࡼࡾṚ⁛ࡍࡿℐ⬊ࡣ࡝ࡢࡼ࠺࡟㑅ูࡉࢀ࡚࠸ࡿ
ࡢ࠿ࠊࡑࡢศᏊᶵᵓࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࡀᮏ◊✲ࡢ┠ⓗ࡛࠶ࡿࠋ
100 ಶ๓ᚋࡢ༸Ꮚࢆ᤼༸ࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿ⸆
๣㸦PMSG/hCG ➼࡛㐣᤼༸ࢆㄏᑟࡍࡿ࡜࣐࢘ࢫࡢ
ሙྜࠊ10-20 ಶ⛬ᗘࡀ᤼༸ࡉࢀࡿ㸧ࢆ⏝࠸࡚᤼༸ࢆ
ㄏᑟࡋࡓ࣐࢘ࢫࡢ༸ᕢ࡜㏻ᖖࡢ㐣᤼༸ࢆㄏᑟࡋࡓ
࣐࢘ࢫࡢ༸ᕢࢆ⏝࠸࡚ゎᯒࢆ⾜ࡗࡓ⤖ᯝࠊ
estradiol-17β ࡜࢔ࢡࢳࣅࣥࡢ㔞ࡀ㏻ᖖࡢ㐣᤼༸ㄏᑟ࣐࢘ࢫࡢ༸ᕢ࡜ẚ㍑ࡋ࡚᭷ព࡟ୖ᪼ࡋ࡚࠸ࡿࡇ
࡜᫂ࡽ࠿࡜࡞ࡗࡓࠋࡇࡢ⤖ᯝࡣࠊℐ⬊㑅ᢥ࡟ୖグᅉᏊࡀ㛵୚ࡋ࡚࠸ࡿࡇ࡜ࢆ♧၀ࡍࡿࠋ⌧ᅾࠊୖグᅉᏊࡀୖ᪼ࡍࡿ⌮⏤࡟ࡘ࠸࡚ゎᯒࢆ⾜ࡗ࡚࠸ࡿࠋ
ㄽᩥ
1. *Hagiwara A., *#Ogiwara K., Sugama N., Yamashita
M., #Takahashi T (2020). Inhibition of medaka
ovulation by gap junction blockers due to its disrupting
effect on the transcriptional process of LH-induced
Mmp15 expression. Gen. Comp. Endocrinol.
288:113373. doi: 10.1016/j.ygcen.2019.113373. (*:These two authors are equally contributed to thiswork. #: These two are co-corresponding authors.)Ꮫ఍Ⓨ⾲Ⲷཎඞ┈ࠊⴗཎⲁࠊὪ㙊࡞ࡘࠊᒣୗṇවࠊ㧗ᶫᏕ⾜
Gap junction blockers ࡟ ࡼ ࡿ࣓ ࢲ࢝ ᤼༸ ࡢ㜼ᐖ―LH ㄏᑟᛶࡢ᤼༸㓝⣲ MT2-MMP ࡢⓎ⌧ㄏᑟ࡟࠾ࡅࡿ Gap junction ࡢ㛵୚ ➨ 91 ᅇ᪥ᮏື≀Ꮫ఍㸦࢜ࣥࣛ࢖ࣥ㸧ࠊ2020 ᖺ 9 ᭶ 4-5 ᪥Ⲷཎඞ┈ࠊ㧗ᶫᏕ⾜࣓ࢲ࢝᤼༸㓝⣲ MT2-MMP ࡢⓎ⌧ㄏᑟ࡟࠾ࡅࡿ
Gap junction ࡢ㛵୚ ➨ 6 ᅇ໭ᾏ㐨኱Ꮫ㒊ᒁᶓ᩿ࢩ࣏ࣥࢪ࣒࢘㸦࢜ࣥࣛ࢖ࣥ㸧
ࠊ2020 ᖺ 10 ᭶ 19 ᪥㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫศ㔝⏕≀⛉Ꮫ㒊ᮌᮧ ᩔ
㸺◊✲ㄢ㢟ྡ㸼့ங㢮ࡢ⏕Ṫ࡟㛵ࢃࡿࢤࣀ࣒ᶵ⬟࡟㛵ࡍࡿ◊✲㸺฼⏝≧ἣ࣭ᡂᯝ㸼ᙜ◊✲ᐊ࡛ࡣࠊ့ங㢮ࡢ⏕Ṫ࡟࠾ࡅࡿࢤࣀ࣒ᶵ
⬟ࢆゎ᫂ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚ࠊ⏕Ṫჾᐁ࡟࠾ࡅ
ࡿ㑇ఏᏊⓎ⌧ㄪ⠇ᶵᵓࢆㄪᰝࡋ࡚࠸ࡿࠋලయⓗ࡟ࡣ༸ᕢࠊ⢭ᕢࠊ⫾┙࡛Ⓨ⌧ࡍࡿࡉࡲࡊࡲ࡞㑇ఏᏊࡀ࡝ࡢࡼ࠺࡞࣓࢝ࢽࢬ࣒࡛ไᚚࡉࢀ࡚࠸ࡿࡢ࠿ࢆ
ศᏊ࡛ࣞ࣋ࣝㄪ࡭࡚࠾ࡾࠊᚲせ࡟ᛂࡌ࡚㑇ఏᏊࡢᶵ⬟ゎᯒࡶ⾜ࡗ࡚࠸ࡿࠋࡲࡓࠊከࡃࡢࢤࣀ࣒㓄ิ࠿ࡽ㌿෗ࡉࢀࡿ long noncoding RNA ࡢゎᯒࡶ⾜ࡗ࡚࠸ࡿࠋ௒ᖺᗘࡣࠊ⢭Ꮚᙧᡂ࡟࠾࠸࡚᪂ࡓ࡞ࢱ࢖
ࣉࡢከᶵ⬟ᛶࢤࣀ࣒ࢆⓎぢࡋࠊゎᯒࡋࡓࠋᡃࠎࡣࡇࢀࡲ࡛࣐࢘ࢫࡢ⢭Ꮚᙧᡂ࡛㌿෗άᛶ໬ࢆᢸ࠺ከᶵ⬟ᛶࢤࣀ࣒࡜ࡋ࡚ࠊࣉ࣮ࣟࣔࢱ࣮࡜࢚
ࣥࣁࣥࢧ࣮ࡢάᛶࢆేࡏᣢࡘ dual promoter-enhancer࡟╔┠ࡋࡓ◊✲ࢆ㐍ࡵ࡚࠾ࡾࠊ⥙⨶ゎᯒࡢ⤖ᯝ࡞࡝࠿ࡽ୍ḟ⢭ẕ⣽⬊࡟࠾ࡅࡿ㔜せᛶࢆ♧၀ࡍࡿࢹ࣮ࢱࢆᚓ࡚࠸ࡿࠋ௒ᅇᡃࠎࡣࠊࡇࡢ◊✲㐣⛬࡟࠾࠸࡚ࠊ୍ḟ⢭ẕ⣽⬊ู࡛࡞ࢱ࢖ࣉࡢከᶵ⬟ᛶࢤࣀ
࣒ࠕdual enhancer-silencerࠖࢆⓎぢࡋࡓࠋ࣐࢘ࢫ 18␒ᰁⰍయୖࡢ Kctd16 㑇ఏᏊࡢ࢖ࣥࢺࣟࣥ࡟Ꮡᅾࡍ
ࡿࡇࡢࢤࣀ࣒㡿ᇦࢆࠊᡃࠎࡣ DES-K16 ࡜ྡ࡙ࡅࡓࠋ
Chromatin immunoprecipitation-sequencing ࢹ࣮ࢱࡢゎ ᯒ ࠿ ࡽ ࠊ DES-K16 ࡣ ࣐ ࢘ ࢫ ୍ ḟ ⢭ ẕ ⣽ ⬊࡛
H3K4me1ࠊH3K27acࠊH3K27me3 ࡜࠸࠺ 3 ࡘࡢࣄࢫࢺࣥಟ㣭ࡀᴟࡵ࡚㧗࠸᳨࡛ࣞ࣋ࣝฟࡉࢀࡿ㡿ᇦ࡜ࡋ࡚ྠᐃࡉࢀࡓࠋ
ࡇࡢ࠺ࡕ H3K4me1 ࡜ H3K27acࡣ୍⯡࡟࢚ࣥࣁࣥࢧ࣮࡟ぢࡽࢀࡿࣄࢫࢺࣥಟ㣭࡛࠶ࡿࡢ࡟ᑐࡋࠊH3K27me3 ࡣࢧ࢖ࣞࣥࢧ࣮࡟ぢࡽࢀࡿಟ㣭࡛࠶ࡿࠋࡑࡇ࡛ࠊDES-K16 ࡢ㌿෗ㄪ⠇άᛶࢆ in vitro ࣏࣮ࣞࢱ࣮ゎᯒ࡟ࡼࡗ࡚ㄪ࡭ࡓ࡜ࡇࢁࠊ
2 ࡘࡢ⣽⬊✀࡟࠾࠸࡚࠸ࡎࢀࡶ࢚ࣥࣁࣥࢧ࣮άᛶ
ࢆ♧ࡋࡓࠋḟ࡟ࠊ࣐࢘ࢫ୍ḟ⢭ẕ⣽⬊⏤᮶ࡢGC-2spd(ts)⣽⬊࡟࠾࠸࡚ࠊCRISPR/Cas9 ࢆ⏝࠸ࡓࢤࣀ࣒⦅㞟ἲ࡟ࡼࡗ࡚ DES-K16 㓄ิࢆḞኻࡉࡏࡓࠋ
ࡑࡢ⤖ᯝࠊ㦫ࡃ࡭ࡁࡇ࡜࡟ࠊ㏆ഐࡢ Yipf5 㑇ఏᏊࡢⓎ⌧ࡀῶᑡࡍࡿ࡜ྠ᫬࡟ࠊࢤࣀ࣒⦅㞟๓ࡢ⣽⬊ࡸࢥࣥࢺ࣮ࣟࣝࡢ⣽⬊࡛ࡲࡗࡓࡃ᳨ฟࡉࢀ࡞࠿ࡗࡓ
Kctd16 㑇ఏᏊࡢⓎ⌧ࡀ DES-K16 ࡢḞኻ࡟ࡼࡗ࡚ά
ᛶ໬ࡋ࡚࠸ࡓࠋࡘࡲࡾࠊDES-K16 ࡣ GC-2spd(ts)⣽⬊࡟࠾࠸࡚ Yipf5 㑇ఏᏊࡢ࢚ࣥࣁࣥࢧ࣮࡜ࡋ࡚ᶵ
⬟ࡍࡿ࡜ྠ᫬࡟ Kctd16 㑇ఏᏊࡢࢧ࢖ࣞࣥࢧ࣮࡜ࡋ

− 17 −

࡚ࡶᶵ⬟ࡍࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋࡇࡢ㌿෗ㄪ⠇άᛶࡣࠊῶᩘศ⿣㐣⛬୍࡛ḟ⢭ẕ⣽⬊࡟࠾࠸࡚ࠊYipf5
㑇ఏᏊࡢⓎ⌧ࡀୖ᪼ࡋࠊKctd16 㑇ఏᏊࡢⓎ⌧ࡀῶᑡࡍࡿࡇ࡜࡜ࡶ୍⮴ࡋ࡚࠸ࡓࠋࡋࡓࡀࡗ࡚ࠊ
DES-K16 ࡣ୍ḟ⢭ẕ⣽⬊࡛࢚ࣥࣁࣥࢧ࣮࡜ࡋ࡚ࡶ
ࢧ࢖ࣞࣥࢧ࣮࡜ࡋ࡚ࡶᶵ⬟ࡍࡿdual enhancer-silencer࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡿࠋࡇࢀࡲ࡛ሗ࿌ࡢ࠶ࡗࡓ
dual enhancer-silencer ࡣࡍ࡭࡚ࠊࡑࡢ࢚ࣥࣁࣥࢧ࣮
άᛶ࡜ࢧ࢖ࣞࣥࢧ࣮άᛶࢆ␗࡞ࡿ✀㢮ࡢ⣽⬊࣭⤌⧊࡛ࡑࢀࡒࢀⓎ᥹ࡍࡿࡢ࡟ᑐࡋࠊDES-K16 ࡣ 1 ࡘࡢ⣽⬊✀࡛୧᪉ࡢάᛶࢆ♧ࡍⅬ࡛᪂ࡓ࡞ࢱ࢖ࣉࡢ
ከᶵ⬟ᛶࢤࣀ࣒࡛࠶ࡿࠋࡇࢀࡲ࡛࡟ᚓࡽࢀࡓ dual
promoter-enhancer ࡢࢹ࣮ࢱࢆྜࢃࡏ࡚⪃࠼ࡿ࡜ࠊ୍ḟ⢭ẕ⣽⬊ࡢ㌿෗ㄪ⠇࡟࠾࠸࡚ከᶵ⬟ᛶࢤࣀ࣒ࡀ㔜せ࡞ᙺ๭ࢆᯝࡓࡍࡇ࡜ࡀ⪃࠼ࡽࢀࡿࠋ

ᩘศ⿣࡟࠾ࡅࡿ⩻ヂไᚚࡢ࣓࢝ࢽࢬ࣒ࡣࠊ୺࡟୧
⏕㢮༸ẕ⣽⬊ࢆ⏝࠸ࡓ⏕໬Ꮫⓗゎᯒ࡟ࡼࡗ࡚◊✲ࡉࢀ࡚ࡁࡓࠋࡋ࠿ࡋࠊmRNA ศᏊࡀ༸⣽⬊㉁࡛ᐇ
㝿࡟࡝ࡢࡼ࠺࡟ไᚚࢆཷࡅࡿ࠿ࡣ࡯࡜ࢇ࡝ศ࠿ࡗ
࡚࠸࡞࠸ࠋᡃࠎࡣ⩻ヂࢆᢚไࡉࢀࡓ cyclin B1 ࡜ Mad2mRNA ࡀ༸⣽⬊㉁࡛㢛⢏≧ࡢᵓ㐀ࢆ࡜ࡿࡇ࡜ࠊῶ
ᩘศ⿣ࡢ➨୍ศ⿣࡟࠾࠸࡚ࡇࡢ㢛⢏ᵓ㐀ࡀᾘኻࡋࠊ
⩻ヂࡀάᛶ໬ࡍࡿࡇ࡜ࢆ♧ࡋ࡚ࡁࡓࠋࡇࢀࡣࠊῶ
ᩘ➨୍ศ⿣࡛⩻ヂࡉࢀࡿᩘⓒ✀㢮ࡢ mRNA ࡢ⩻ヂไᚚᶵᵓࡢࣔࢹࣝ࡜࡞ࡾ࠺ࡿࠋ୍᪉࡛༓✀㢮㏆ࡃ
ࡢ mRNA ࡣῶᩘ➨஧ศ⿣࡛⩻ヂࡉࢀࡿࡀࠊࡇࢀࡽmRNA ࡀ࡝ࡢࡼ࠺࡟⩻ヂࢆไᚚࡉࢀࡿࡢ࠿࡟ࡘ࠸
࡚ࡣ୙࡛᫂࠶ࡗࡓࠋ
Emi2 ࢱࣥࣃࢡ㉁ࡣῶᩘศ⿣ࡢ➨୍ศ⿣⤊஢ᚋ࡟⵳✚ࡋࠊ➨஧ศ⿣࡬ࡢ⛣⾜࡜➨஧ศ⿣࡛ࡢศ⿣
㸺ㄽᩥⓎ⾲㸼
⿦⨨ᙧᡂࠊ࠾ࡼࡧࠊ୰ᮇ࡛ࡢῶᩘศ⿣ࡢ෌೵Ṇ࡟
1. Bandara T.A.M.K., Otsuka K., Matsubara S.,
ᚲ㡲ࡢᅉᏊ࡛࠶ࡿࠋᮏ◊✲࡛ᡃࠎࡣࠊ࣐࢘ࢫ༸ẕ
Shiraishi A., Satake H., and Kimura A.P. (2021) A⣽⬊࡟࠾࠸࡚ Emi2 mRNA ࡀ cyclin B1 mRNA ࡜ྠ
dual enhancer-silencer element, DES-K16, in mouseᵝ࡟⩻ヂࢆᢚไࡉࢀࠊ㢛⢏≧ࡢᵓ㐀ࢆ࡜ࡿࡇ࡜ࢆ
spermatocyte-derived GC-2spd(ts) cells. Biochem.
᫂ࡽ࠿࡟ࡋࡓࠋࡇࢀࡽ mRNA ࡣ␗࡞ࡿ㢛⢏ࢆᙧᡂ
Biophys. Res. Commun. 534: 1007-1012.
ࡋࡓࠋࡉࡽ࡟ࠊEmi2 mRNA ࡢ⩻ヂᢚไࡣ cyclin B1
2. Mayama S., Hamazaki N., Maruyama Y., Matsubara
mRNA ࡜ࡣ␗࡞ࡾࠊῶᩘศ⿣ࡢ➨஧ศ⿣㸦ῶᩘศ
S., and Kimura A.P. (2020) Transcriptional activation⿣෌㛤ᚋ 12ࠥ18 ᫬㛫㸧࡛ゎ㝖ࡉࢀࡿࡇ࡜ࢆ᫂ࡽ࠿
of the mouse Scd2 gene by interdependent enhancers
and long noncoding RNAs in ovarian granulosa cells.
࡟ࡋࡓࠋ⯆࿡῝࠸ࡇ࡜࡟ࠊRNA ⤖ྜࢱࣥࣃࢡ㉁ࡢ
J. Reprod. Dev. 66: 435-444.
HuR ࡜ HuB ࡣ cyclin B1 ࡜ Emi2 mRNA ࡢ୧᪉࡟⤖3. Takahashi N., Kimura A.P., Ohmura K., Naito S.,ྜࡋࡓࡀࠊྠࡌࡃ RNA ⤖ྜࢱࣥࣃࢡ㉁ࡢ Pumilio1
Yoshida M., and Ieko M. (2020) Knockdown ofࡣ cyclin B1 mRNA ࡜⤖ྜࡍࡿࡶࡢࡢࠊEmi2 mRNA
long noncoding RNA Dreh facilitates cell surface࡜ࡣ⤖ྜࡋ࡞࠸ࡇ࡜ࢆ♧ࡋࡓࠋヨ㦂⟶ෆ࡛mRNA
GLUT4 expression and glucose uptake through the࡟⤖ྜࡍࡿࢱࣥࣃࢡ㉁ࢆ⥙⨶ⓗ࡟ゎᯒࡋࡓ⤖ᯝࠊ
involvement of vimentin in 3T3-L1 adipocytes.
Emi2mRNA ࡟≉␗ⓗ࡟⤖ྜࡍࡿೃ⿵ࢱࣥࣃࢡ㉁Gene 735: 144404.
ࢆ 71 ✀㢮ྠᐃࡋࡓࠋᡃࠎࡣࡇࡢ୰࡛ Tdrd3 ࢱࣥࣃ㸺Ꮫ఍Ⓨ⾲㸼
ࢡ㉁࡟↔Ⅼࢆᙜ࡚ࠊࡇࡢࢱࣥࣃࢡ㉁ࡀ Emi2 mRNA
1. బ⸨୔⏕ࠊబ⸨ඃ⾰ࠊᑎᑿ⨾✑ࠊ㧗⏣ಟ἞ࠊᮌ࡜┤᥋⤖ྜࡍࡿࡇ࡜ࠊ༸⣽⬊㉁࡛ Emi2 ࡢ RNA 㢛ᮧᩔࠕ࣐࢘ࢫ⢭ᕢ≉␗ⓗ࡞ long noncoding RNA
࡛࠶ࡿ Tesra ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࡢ⾲⌧ᆺゎᯒࠖ ⢏࡜ඹᒁᅾࡍࡿࡇ࡜ࢆ♧ࡋࡓࠋ
Tdrd3 ࡢᶵ⬟ࢆゎᯒࡍࡿࡓࡵࠊ࣐࢘ࢫ༸ẕ⣽⬊࡟᪥ᮏື≀Ꮫ఍໭ᾏ㐨ᨭ㒊➨ 65 ᅇ኱఍㸦࢜ࣥࣛ࢖ᢠ Tdrd3 ᢠయࢆᚤ㔞ὀධࡋࠊῶᩘศ⿣ࢆ෌㛤ࡉࡏࣥ㛤ദࠊ2021 ᖺ 3 ᭶ 20 ᪥㸧ࡓࠋࡇࢀࡽࡢ༸ẕ⣽⬊࡛ࡣࠊ➨஧ศ⿣ࡢึᮇ࡟࠾
ࡅࡿ Emi2 ࢱࣥࣃࢡ㉁ࡢྜᡂࡀ㜼ᐖࡉࢀࡓࡶࡢࡢࠊ
⏕≀⛉Ꮫ㒊㒊㛛 ⏕ṪⓎ⏕⏕≀ᏛᏛศ㔝ࡑࡢᚋࢱࣥࣃࢡ㔞ࡣࢥࣥࢺ࣮ࣟࣝࡢ༸ẕ⣽⬊࡜ྠᑠ㇂ ཭ஓ
⛬ᗘ࡜࡞ࡗࡓࠋࡇࢀࡣࠊᢠయ࡟ࡼࡗ࡚ Tdrd3 ࡢᶵ⬟ࡀ㒊ศⓗ࡟㜼ᐖࡉࢀࡓࡓࡵ࡜⪃࠼ࡽࢀࡿࠋḟ࡟⏕Ṫ⣽⬊ࡣ 2 ᅇࡢ㐃⥆ࡋࡓ⣽⬊ศ⿣ࠊῶᩘ➨୍ᡃࠎࡣ TRIM-Away ࢩࢫࢸ࣒࡜ᢠ Tdrd3 ᢠయࢆ⏝࠸ࠊศ⿣࡜➨஧ศ⿣ࢆṇᖖ࡟㐍⾜ࡍࡿࡇ࡜࡛ᙧᡂࡉࢀ
ࡿࠋ༸ẕ⣽⬊ࡣῶᩘศ⿣ࢆ➨୍ศ⿣๓ᮇ࡛೵Ṇࡋࠊ ༸ẕ⣽⬊࡟࠾ࡅࡿ Tdrd3 ࢱࣥࣃࢡ㉁ࢆ≉␗ⓗ࡟ศゎࡋࡓࠋTdrd3 ࢆࣀࢵࢡࢲ࢘ࣥࡋࡓ༸ẕ⣽⬊ࡣࠊῶከࡃࡢᅉᏊࢆ⵳✚ࡍࡿࠋ㏆ᖺࡢ◊✲࠿ࡽࠊ1 ୓✀㢮ࢆ㉸࠼ࡿ mRNA ࡀᡂ㛗㐣⛬࡛⵳✚ࡉࢀࡿࡇ࡜ࠊ ᩘ➨୍ศ⿣ࢆṇᖖ࡟㐍⾜ࡍࡿࡶࡢࡢࠊ➨୍ศ⿣⤊஢ᚋ࡟๓᰾ࢆᙧᡂࡋࠊ࡞࠾࠿ࡘࠊ➨஧ศ⿣ࡢ⣳㗽ࡇࢀࡽࡢ࡞࠿࡛༓✀㢮௨ୖࡢ mRNA ࡣ⩻ヂࢆᢚไయࢆᙧᡂࡍࡿࡇ࡜ࡀ࡛ࡁ࡞࠿ࡗࡓࠋ⯆࿡῝࠸ࡇ࡜ࡉࢀࢱࣥࣃࢡ㉁ࢆྜᡂࡋ࡞࠸≧ែ࡛Ꮡᅾࡍࡿࡇ࡜
࡟ࠊTdrd3 ࡢࣀࢵࢡࢲ࢘ࣥࡣ➨஧ศ⿣࡟࠾ࡅࡿ
ࡀ᫂ࡽ࠿࡜࡞ࡗ࡚ࡁࡓࠋࡇࢀࡽ mRNA ࡣῶᩘศ⿣
࡜⬇Ⓨ⏕ࡢࡑࢀࡒࢀ࡟Ỵࡵࡽࢀࡓ᫬ᮇ࡟⩻ヂࡉࢀࠊ Emi2 ࢱࣥࣃࢡ㉁ࡢྜᡂࢆⴭࡋࡃపୗࡉࡏࡓࡀࠊ➨୍ศ⿣࡟࠾ࡅࡿ cyclin B1 ࡜ Mad2 ࢱࣥࣃࢡ㉁ࡢྜ
ཷ⢭ྍ⬟࡞༸ࡢᙧᡂ࡜ึᮇⓎ⏕ࢆ㐍⾜ࡉࡏࡿࠋῶ
− 18 −

ᡂ࡟ᙳ㡪ࢆ୚࠼࡞࠿ࡗࡓࠋ௨ୖࡢ⤖ᯝ࠿ࡽࠊTdrd3
ࡣ➨஧ศ⿣࡟࠾ࡅࡿ Emi2 mRNA ࡢ⩻ヂࢆಁ㐍ࡍࡿࡇ࡜ࠊEmi2 ࢱࣥࣃࢡ㉁ࡢྜᡂࢆ௓ࡋ࡚ῶᩘ➨஧ศ⿣ࢆṇᖖ࡟㐍⾜ࡉࡏࡿᅉᏊ࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿
࡜࡞ࡗࡓࠋ
Ⓨ⾲ㄽᩥ
Takei N, Takada Y, Kawamura S, Sato K, Saitoh A,
Bormann J, Yuen WS, Carroll J, Kotani T. (2020)
Changes in subcellular structures and states of pumilio1
regulate the translation of target Mad2 and cyclin B1
mRNAs. Journal of Cell Science, 133: jcs249128.
Takada Y, Lyyappan R, Susor A, Kotani T. (2020)
Posttranscriptional regulation of maternal Pou5f1/Oct4
during mouse oogenesis and early embryogenesis.
Histochemistry and Cell Biology, 154: p609-620.
Balboula AZ, Schindler K, Kotani T, Kawahara M,
Takahashi M. (2020) Vitrification-induced activation oflysosomal cathepsin B perturbs spindle assembly
checkpoint function in mouse oocytes. Molecular Human
Reproduction, 26: p689-701.

Ꮫ఍Ⓨ⾲Ṋ஭ኟᾏ, ᒣᮏ㞝ᗈ, ᑠ㇂཭ஓ㸸࣐࢘ࢫ༸ẕ⣽⬊࡟
࠾ࡅࡿ RNA 㢛⢏ࢆ௓ࡋࡓ Emi2 mRNA ࡢ⩻ヂไᚚ㸸RNA ⤖ྜࢱࣥࣃࢡ㉁ࡢ✀㢮ࡢ㐪࠸࡟ࡼࡿ⩻ヂ᫬ᮇࡢㄪ⠇. ➨ 6 ᅇ໭኱࣭㒊ᒁᶓ᩿ࢩ࣏ࣥࢪ࣒࢘,2020 ᖺ 10 ᭶ 19 ᪥, ໭ᾏ㐨኱Ꮫ་Ꮫ㒊Ꮫ཭఍㤋ࣇࣛࢸ࣮࣍ࣝ㸦web 㛤ദ㸧⏕≀⛉Ꮫ㒊㒊㛛 ከᵝᛶ⏕≀Ꮫศศ㔝ᑠட ୍ᘯ㸦ᾏỈ฼⏝㸧
Ⓨ⾲ㄽᩥ
Santiañez, W.J.E. Al‐bader, D., West, J.A., Bolton,J.J. andKogame, K. (2020) Status, morphology, and phylogenetic
relationships of Iyengaria (Scytosiphonaceae, Phaeophyceae),
a brown algal genus with a disjunct distribution in the
Indian Ocean. Phycological Research 68: 323–331.
Poza, A.M., Santiañez, W.J.E., Croce, M.E., Gauna,
M.C., Kogame, K. and Parodi, E.R. (2020) Cryptic
haploid stages in the life cycle of Leathesia marina(Chordariaceae, Phaeophyceae) under in vitro culture.
Journal of Phycology 56: 1349-1361.
Hoshino, M., Ino, C., Kitayama, T. and Kogame, K. (2020)
Integrative systematics approaches revealed that therare red alga Schimmelmannia (Shimmelmanniaceae,
Acrosymphytales) from Japan is a new species: thedescription of S. benzaiteniana sp. nov. PhycologicalResearch 68: 290-297.

Ꮫ఍Ⓨ⾲⊦㔝༓ᑜ㸪ᫍ㔝㞞࿴㸪㜿㒊๛ྐ㸪ᅄࢶ಴඾⁠㸪
Klochkova, N.㸪ᑠட୍ᘯ㸸໭ᾏ㐨⏘⣚⸴ࢡࢩ࣋ࢽ
ࣄࣂᒓ㸦Ptilota㸧ࡢ⣔⤫ศ㢮Ꮫⓗ◊✲㸪᪥ᮏ⸴㢮Ꮫ఍➨ 45 ᅇ኱఍㸪2021 ᖺ 3 ᭶ 16㸪17 ᪥㸪ᮾிᾏὒ኱Ꮫ㸦ᮾி㒔㸧ᫍ㔝 㞞࿴㸪໭ᒣ ኴᶞ㸪ᑠட ୍ᘯ㸸┿ṇ⣚⸴ࣄࣅࣟ࢘ࢻᒓ㸦Dudresnaya㸧ࡢ⣔⤫ศ㢮㸪᪥ᮏ⸴㢮Ꮫ఍➨ 45 ᅇ኱఍㸪2021 ᖺ 3 ᭶ 16㸪17 ᪥㸪ᮾிᾏὒ኱Ꮫ㸦ᮾி㒔㸧
Dy, M.J.C, Hoshino, M., Abe, T., Yotsukura, N.,
Klochkova, N., Lee, K.M., Boo, S.M. and Kogame, K.:
A new species of Colpomenia (Scytosiphonaceae,
Phaeophyceae) from Hokkaido, Japan and Magadan,
Russia, The 12th International Phycological Congress(IPC 12), March 22-26, 2021, Chile (online)㒊㛛 ከᵝᛶ⏕≀Ꮫศศ㔝⏕≀⛉Ꮫ㒊᯳ཎ ᏹ㸦ᾏỈ฼⏝㸧ㄽᩥ
Hookabe, N. and Kajihara, H. 2020. Taxonomic
reappraisal of Lineus longifissus Auct. (Nemertea:
Pilidiophora) from Japan for the first time in 122
years. Zoological Science 37: 467–475.
Jimi, N., Minokawa, T., Miura, T., and Kajihara, H.
2020. Meiobenthic polychaete Dinophilus sp. cf.
gyrociliatus (Annelida: Dinophilidae) from Japan
with SEM observation and DNA barcodes. Species
Diversity 25: 213–218.
Okamoto, N., Oya, Y., and Kakui, K. 2020. A new
species of Zeuxo (Crustacea: Peracarida: Tanaidacea)
from Japan, with remarks on carapace pigmentation
as a potentially useful taxonomic character. Marine
Biology Research 16: 411–422.

⏕≀⛉⛉Ꮫ㒊㒊㛛 ከᵝᛶ⏕≀Ꮫศศ㔝ຍ⸨ ᚭ
ᙜ◊✲ᐊ࡛ࡣ㸪ࡉࡲࡊࡲ࡞㔝⏕ࢩࣙ࢘ࢪࣙ࢘ࣂ
࢚✀ࢆᑐ㇟࡟㸪⣔⤫Ꮫ◊✲ࡸ㞟ᅋ㑇ఏᏛ◊✲ࢆ⾜ࡗ࡚࠸ࡿ㸬ࡲࡓ㸪㣫⫱ྍ⬟࡞ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࡟
ࡘ࠸࡚ࡣ㸪㔝እ࡛᥇㞟ࡋࡓಶయࢆᐇ㦂⏕≀Ჷෆ࡛⥅௦㣫⫱ࡋ㸪◊✲࡟฼⏝ࡋ࡚࠸ࡿ㸬1) Hirtodrosophila ᒓࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ 3 ✀ࡢ⏕ែⓗ≉ᛶ࡜㑇ఏศ໬
Hirtodrosophila trilineata㸪H. trivittata㸪࠾ࡼࡧ H.
ussurica ࡢ 3 ✀ࡣ㸪ᙧែⓗ࡟ࡼࡃఝࡓ࢟ࣀࢥ㣗ᛶࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࡛࠶ࡿ㸬ඛ⾜◊✲࡛ࡣ㸪ࡇࢀࡽࡢᐤ୺㑅ዲᛶࡀ␗࡞ࡿྍ⬟ᛶࡀᣦ᦬ࡉࢀ࡚࠸ࡿࡶ
ࡢࡢ㸪ࡑࡢヲ⣽ࡣ୙࡛᫂࠶ࡿ㸬ࡑࡇ࡛㸪ࡇࢀࡽ 3− 19 −

✀ࡢ㣗ᛶ࡟㛵ࡍࡿᇶ♏᝟ሗࢆ཰㞟ࡍ࡭ࡃ㸪ᡂ⹸ಶయ㔝እ࡛᥇㞟ࡋ㸪ᾘ໬⟶ࡢෆᐜ≀ࢆㄪ࡭ࡓ㸬ࡑࡢ⤖ᯝ㸪ᾘ໬⟶ࡣ࢟ࣀࢥࡢ⬊Ꮚ࡛‶ࡓࡉࢀ࡚࠸ࡓࡇ
࡜࠿ࡽ㸪ᡂ⹸ࡣ⬊Ꮚࢆ฼⏝㈨※࡜ࡋ࡚࠸ࡿࡇ࡜ࡀ
᫂ࡽ࠿࡜࡞ࡗࡓࠋࡲࡓ㸪3 ✀ࡢ COI 㑇ఏᏊࡢሷᇶ㓄 ิ ࢆ Ỵ ᐃ ࡋ 㸪 ⣔ ⤫ ゎ ᯒ ࢆ ⾜ ࡗ ࡓ ࡜ ࡇ ࢁ 㸪 H.
ussurica ࡣ௚ࡢ 2 ✀࡜ࡣࢡ࣮ࣞࢻࢆᙧᡂࡏࡎ㸪ูࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚✀࡜ጜጒ⩌ࢆᙧᡂࡋࡓࠋ
2) Drosophila quinaria ✀⩌ࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢ༢
⣔⤫ᛶࡢ᳨ドD. quinaria ✀⩌ࡣ㸪ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ᒓࡢ୰࡛ࡶ
࢟ࣀࢥ㣗ࡢ✀ࡀከࡃྵࡲࢀࡿศ㢮⩌࡛࠶ࡿ㸬ᚑ᮶㸪ࡇࡢ✀⩌ࡣ༢⣔⤫⩌࡛࠶ࡿ࡜⪃࠼ࡽࢀ࡚ࡁࡓࡀ㸪㏆ᖺࡢศᏊ⣔⤫Ꮫ◊✲࠿ࡽ㸪ಶࠎࡢ㑇ఏᏊ⣔ᅗࢆ㔜どࡋࡓゎᯒἲࢆ⏝࠸ࡿ࡜㸪ᚲࡎࡋࡶ༢⣔⤫⩌࡟࡞ ࡽ ࡞ ࠸ ࡇ ࡜ ࡀ ᣦ ᦬ ࡉ ࢀ ࡚ ࠸ ࡿ 㸬 ࡑ ࡇ ࡛ 㸪 D.
quinaria ✀⩌ࡢ༢⣔⤫ᛶࢆヲ⣽࡟᳨ドࡍࡿࡇ࡜ࢆ
┠ⓗ࡟㸪ࢱࢡࢯࣥࢧࣥࣉࣜࣥࢢ࡜㓄ิ᝟ሗࢆቑࡸ
ࡋ࡚⣔⤫ゎᯒࢆ⾜ࡗࡓ⤖ᯝ㸪࡝ࡢゎᯒἲࢆ⏝࠸࡚ࡶ㸪D. quinaria ✀⩌ࡣ༢⣔⤫ⓗ࡟ࡲ࡜ࡲࡾ㸪ᮏ✀⩌ࡢ༢⣔⤫ᛶࡀᙉࡃᨭᣢࡉࢀࡓ㸬ࡉࡽ࡟㸪ࢥࢻࣥ
1 ␒┠࡜ 2 ␒┠ࡢሷᇶࡢࡳࢆゎᯒ࡟⏝࠸ࡓ㝿࡟ࡣ㸪ᚑ᮶࡜ྠࡌࢱࢡࢯࣥࢧࣥࣉࣜࣥࢢ࡛⣔⤫ゎᯒࢆ⾜ࡗ࡚ࡶྠᵝࡢ⤖ᯝࡀᚓࡽࢀࡓࡇ࡜࠿ࡽ㸪ಶࠎࡢ㑇ఏᏊ⣔ᅗࢆ㔜どࡋࡓゎᯒἲࡣ㸪௚ࡢゎᯒἲ࡟ẚ࡭㸪ࢥࢻࣥ 3 ␒┠ࡢሷᇶ⤌ᡂࡢᙳ㡪ࢆཷࡅࡸࡍ࠸ྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬3) ࢩ ࣙ ࢘ ࢪ ࣙ ࢘ ࣂ ࢚ ࡢ ࢟ ࣀ ࢥ ẘ ⪏ ᛶ ࡢ ᳨ ド 㸸
Drosophila ᒓ quinaria ✀⩌࡟ᒓࡍࡿࢩࣙ࢘ࢪࣙ࢘
ࣂ࢚ࡣ㸪௚ࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࡟࡜ࡗ࡚᭷ẘ࡞࢟ࣀࢥ⏤᮶ࡢẘ࡛࠶ࡿ α ࢔࣐ࢽࢳࣥ࡟⪏ᛶࢆᣢࡘ஦
ࡀ▱ࡽࢀ࡚࠸ࡿ㸬ࡋ࠿ࡋ࡞ࡀࡽ㸪ࡇࡢᙧ㉁ࡀ
quinaria ✀⩌ࡢ⣔⤫࡛≉␗ⓗ࡟⋓ᚓࡉࢀࡓࡶࡢ࠿㸪࠶ࡿ࠸ࡣ௚ࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚⣔⤫࡛ࡶ⋓ᚓࡉࢀ࡚࠸ࡿ࠿ࡣ୙࡛᫂࠶ࡿ㸬ࡇࡢၥ㢟ࢆ᫂ࡽ࠿࡟ࡍࡿ
ࡓࡵ㸪ᙜ᪋タ࡛⥅௦㣫⫱ࢆ⾜ࡗ࡚࠸ࡿ quinaria ✀⩌࠾ࡼࡧ௚ࡢࢢ࣮ࣝࣉࡢ࠸ࡃࡘ࠿ࡢࢩࣙ࢘ࢪࣙ࢘
ࣂ࢚࡟ࡘ࠸࡚㸪α ࢔࣐ࢽࢳࣥࢆྵࡴ㣵࡛ᡂ⹸ࢆ㣫⫱ࡋ㸪2 㐌㛫ᚋࡢ⏕Ꮡ⋡ࢆẚ㍑ࡍࡿࡇ࡜࡛࢟ࣀࢥ
ẘ⪏ᛶࡢホ౯ࢆ⾜ࡗࡓ㸬ࡑࡢ⤖ᯝ㸪quinaria ✀⩌࡜ࡣ⣔⤫ⓗ࡟㞳ࢀࡓ㠀࢟ࣀࢥ㣗ࡢ✀࡛ࡶ㸪α ࢔࣐ࢽࢳࣥ࡟⪏ᛶࢆᣢࡘࡶࡢࡀㄆࡵࡽࢀࡓࡇ࡜࠿ࡽ㸪
ࡇࡢᙧ㉁ࡀ quinaria ✀⩌ࡔࡅ࡛≉␗ⓗ࡟⋓ᚓࡉࢀࡓࢃࡅ࡛ࡣ࡞࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬

species. Zootaxa 4789:1-54.

኱Ꮫ㝔㎰Ꮫ◊✲㝔ᇶ┙◊✲㒊㛛 ⏕≀㈨※⛉Ꮫศ㔝⛅ඖ ಙ୍
◊✲ᚑ஦⪅㸸Ⳣ㔝Ⰻ୍▷⩟ᛶ࡛⛣ື⬟ຊ࡟ஈࡋ࠸㸪ࢧࢵ࣏ࣟࣇ࢟ࣂࢵ
ࢱ Podisma sapporensis ཬࡧ㸪࣑࢝ࢻࣇ࢟ࣂࢵࢱ
Parapodisma mikado ࢆᮦᩱ࡟⏝࠸㸪㞟ᅋ㛫ࡢ㓄അ⾜ືࡢศ໬ࡢ㐍໬ࣉࣟࢭࢫࡸ㸪⏕Ṫ㝸㞳ᶵᵓࡢゎ᫂࡟ྲྀࡾ⤌ࢇ࡛࠸ࡿ㸬≉࡟ࢧࢵ࣏ࣟࣇ࢟ࣂࢵࢱࡣ㸪ࡇࢀࡽࡢ◊✲ࡢᮦᩱ࡜ࡋ࡚㸪௨ୗࡢ 2 Ⅼ࡟࠾࠸࡚≉␗ⓗ࡛࠶ࡿ㸬1㸧ᛶỴᐃࢩࢫࢸ࣒ࡢ 2 ᆺࡀ␗ᡤⓗ࡟Ᏻᐃⓗ࡟Ꮡᅾࡍࡿ㸬໭ᾏ㐨す㒊࡟ࡣ㸪࢜ࢫ XO㸪
࣓ࢫ XX ࡛ᛶỴᐃࡍࡿ XO ࣮ࣞࢫ㞟ᅋࡀ㸪໭ᾏ㐨ᮾ㒊࡟ࡣ࢜ࢫ neo-XY㸪࣓ࢫ neo-XX ࡛ᛶỴᐃࡍࡿ
neo-XY ࣮ࣞࢫ㞟ᅋࡀศᕸࡍࡿ㸬2㸧஺ᑿάᛶ(࢜ࢫࡢ஺ᑿάຊ࡜࣓ࢫࡢ஺ᑿᣄྰຊ)ࡀᆅᇦ㞟ᅋ࡛␗࡞ࡿ㸬ᮏ✀ࡢ࣓ࢫࡣ࢜ࢫ࡟ᑐࡋ࡚஺ᑿᣄྰ⾜ືࢆ♧ࡍࡀ㸪࣓ࢫࡢ஺ᑿάຊࡀᙉ࠸㞟ᅋࡣ࢜ࢫࡢ஺ᑿ
άຊࡶᙉࡃ㸦஺ᑿάᛶᙉ㸧㸪࣓ࢫࡢ஺ᑿᣄྰຊࡀᙅ
࠸㞟ᅋࡣ࢜ࢫࡢ஺ᑿάຊࡶᙅ࠸㸦஺ᑿάᛶᙅ㸧㸬ࡑࡢࡓࡵ㸪㞟ᅋ㛫஺㓄ࢆࡉࡏࡿ࡜㸪஺㓄๓㝸㞳ࡸࣛࣥࢲ࣒஺㓄ࡣ࡯࡜ࢇ࡝ぢࡽࢀࡎ㸪஺ᑿάᛶࡀᙉ࠸
㞟ᅋࡢ࢜ࢫ࡜஺ᑿάᛶࡀᙅ࠸㞟ᅋࡢ࣓ࢫ㛫ࡢ஺ᑿࡀ㢖⦾࡟⏕ࡌ㸪㠀ᑐ⛠࡞஺㓄ࣃࢱ࣮ࣥ࡟࡞ࡿ㸬 ᭦࡟ᮏ✀࡟ࡣᛶỴᐃࢩࢫࢸ࣒ࡢ 2 ᆺ࡜ࡣ㛵ಀ࡞ࡃ㸪యⰍ࡟࠾࠸࡚㸪໭ᾏ㐨ෆ࡟ᗈࡃศᕸࡍࡿ୍⯡ⓗ࡞⥳Ⰽᆺ࡜㸪≉␗࡞యⰍࢆᣢࡘ㯮Ⰽᆺࡢ 2 ᆺࡶᏑᅾࡍࡿ㸬㯮Ⰽᆺࡣ㸪⥳Ⰽᆺࡢᆅᇦ㞟ᅋ㛫࡟ぢࡽࢀࡿⰍᙬࡸ㯮Ⰽ᮲ࡢ᭷↓࡞࡝ࡢഹ࠿࡞ኚ␗࡜ࡣⴭ
ࡋࡃ␗࡞ࡿ㸦ୗᅗ㸧㸬௨๓ࡣ␃ⴌᕷ࿘㎶ࡢࡈࡃ⊃࠸⠊ᅖ࡟ࡢࡳศᕸࡍࡿ≉␗࡞యⰍኚ␗㞟ᅋ࡜⪃࠼ࡽࢀ࡚࠸ࡓࡀ㸪ᡃࠎࡢㄪᰝ࡟ࡼࡗ࡚༡໭࡟ 45 ࢟ࣟ㸪ᮾす࡟ 30 ࢟ࣟ⛬ࡢ⠊ᅖ࡟ศᕸࡍࡿࡇ࡜ࡀ᫂ࡽ࠿
࡟࡞ࡗࡓ㸬⾜ືᐇ㦂ࡢ⤖ᯝ㸪୧యⰍᆺࡢ㛫࡟ࡣ஺ᑿ๓㝸㞳ࡣᏑᅾࡋ࡞࠿ࡗࡓ㸬ࡑࡢࡓࡵ᫖ᖺᗘ࠿ࡽ㸪యⰍࡀ␗࡞ࡿ㞟ᅋ㛫஺㓄࡛ᚓࡽࢀࡓ༸࠿ࡽᏤ໬⋡ࡸᡂ⹸ࡢయⰍࢆㄪ࡭㸪యⰍ 2 ᆺࡀᏑᅾࡍࡿ⌮⏤ࢆ᳨ドࡋ࡚࠸ࡿ㸬ㄅୖⓎ⾲
1. Toda, M.J., Banziger, H., Sati, P.C., Rajendra, F.S.,
Suwito, A., Katoh, T. (2020) Taxonomy andevolution of asymmetric male genitalia in thesubgenus Ashima Chen (Diptera: Drosophilidae:
Phortica Schiner), with descriptions of seven new− 20 −

ᅗ 1 ࢧࢵ࣏ࣟࣇ࢟ࣂࢵࢱࡢ⥳Ⰽᆺ࡜㯮ⰍᆺࡢయⰍࡢ㐪࠸ ⌧ᅾࡲ࡛㸪ࢧࢵ࣏ࣟࣇ࢟ࣂࢵࢱࡢ㉺෤༸ࡢ᭱㐺࡞ಖᏑ᪉ἲ㸪Ꮴ໬᮲௳ࡣ☜❧ࡉࢀ࡚࠾ࡽࡎ㸪ྠ㞟ᅋྠኈࡢ㞤㞝ࡢ⤌ࡳྜࢃࡏ࡛ࡢᏤ໬⋡ࡶ 20㹼30㸣࡜ప࠸㸬᫖ᖺᗘࡣ㸪㯮Ⰽᆺ♂࡜⥳Ⰽᆺ♀ࡢ⤌ࡳྜࢃࡏ࡛ࡣᏤ໬⋡ࡣ 17㸣㸪⥳Ⰽᆺ♂࡜㯮Ⰽᆺ♀ࡢ⤌ࡳྜࢃࡏ࡛ࡣ 7㸣ࡔࡗࡓ㸬࢜ࢫ࡜࣓ࢫࡢ࡝ࡕࡽࡢయ
Ⰽࡀ F1 ࡢయⰍ࡟ᙳ㡪ࢆཬࡰࡍ࠿᫂ࡽ࠿࡛ࡣ࡞࠸
ࡀ㸪⥳Ⰽᆺ♂࡜⤌ࡳྜࢃࡏࡓ᫬ࡢ㯮Ⰽᆺ♀ࡢ༸ࡢᏤ໬⋡ࡢపࡉࡀ㸪㯮Ⰽᆺ㞟ᅋࡀᗈࡀࡗ࡚࠸࡞࠸஦࡟
ᙳ㡪ࢆཬࡰࡋ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡓ㸬ࢧࢵ࣏ࣟࣇ࢟ࣂࢵࢱࡢᗂ⏕ࡢయⰍࡣⲔⰍ㹼㯮Ⰽ࡛㸪ᡂ⹸ࡢయⰍࡣ᭱⤊⩚໬ᚋࡲ࡛ศ࠿ࡽ࡞࠸㸬ࡋ࠿ࡋ࡞ࡀ
ࡽ㸪᫖ᖺᗘࡣᚓࡽࢀࡓᏤ໬ᗂ⹸ࡀᡂ⹸ࡲ࡛⫱ࡓࡎ㸪యⰍࡀ␗࡞ࡿ㞟ᅋ㛫஺㓄࡛࡝ࡕࡽࡢయⰍࡀฟ⌧ࡍࡿ࠿ࡣศ࠿ࡽ࡞࠿ࡗࡓ㸬 ᮏᖺᗘࡣᡂ⹸࡟⮳ࡿࡲ࡛ࡢ㣫⫱ᢏ⾡ࢆ☜❧ࡋ㸪㞤㞝ࡢ࡝ࡕࡽࡀ F1 ࡢయⰍ࡟ᙳ㡪ࢆ୚࠼࡚࠸ࡿࡢ
࠿ࢆ᫂ࡽ࠿࡟ࡋ㸪㯮Ⰽᆺࡀ⥔ᣢࡉࢀ࡚࠸ࡿ࣓࢝ࢽ
ࢬ࣒ࡢゎ᫂ࢆ┠ᣦࡋࡓ㸬ࡋ࠿ࡋ࡞ࡀࡽ㸪ࢥࣟࢼ⚝࡛┴ࢆࡲࡓࡄ⛣ືࡢ⮬⢔せㄳࡀฟࡉࢀ㸪ᮾி⁫ᅾ୰ࡔࡗࡓ◊✲ᚑ஦⪅ࡀ໭ᾏ㐨࡬⛣ື࡛ࡁࡎ㸪ࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮ෆ࡛ࡢ㣫⫱ᐇ㦂ࡀ⾜࠼࡞࠿ࡗࡓ㸬ࡑࡇ࡛㉺෤༸ࢆᮾி࡬⛣㏦ࡋ㸪Ẽࡸ᪥㛗᮲௳࡞࡝ࡀㄪᩚ࡛ࡁ࡞࠸≧ែ࡛㣫⫱ᐇ㦂ࢆ⥅⥆ࡋࡓ㸬ࡇࡢࡼ࠺࡞᮲௳ୗ࡛ࡶ᫖ᖺᗘྠᵝ⥳Ⰽᆺ♂࡜㯮Ⰽᆺ♀ࡢ⤌ྜࡏࡢ༸ࡀ᭱ࡶᏤ໬⋡ࡀపࡃ㸪ࡲࡓᗂ⏕ࡢ⏕Ꮡ᪥ᩘࡶ᭱ࡶᑡ࡞ࡃ㸪ࡇࡢ⤌ࡳྜࢃࡏ࡟ࡣఱ࠿ࡋࡽࡢ஺ᑿᚋ᥋ྜᚋ㝸㞳ࡀᏑᅾࡍࡿྍ
⬟ᛶࡀ♧၀ࡉࢀࡓ㸦2 ᖺ༸ࡢྍ⬟ᛶࡀ࠶ࡿࡓࡵ㸪ṇ☜࡞Ꮴ໬⋡ࡣ 2021 ᖺࡢ᫓࡟ุ᫂㸧㸬 ◊✲ᚑ஦⪅ࡀ໭ᾏ㐨࡬ࡢ⛣ືࡀྍ
⬟࡟࡞ࡗࡓᚋ࡟㸪㯮Ⰽᆺ㞟ᅋࡢศᕸᇦࢆ᭦࡟ヲ⣽࡟ㄪᰝ
ࡋࡓ㸬ࡑࡢ⤖ᯝ㸪ࡇࢀࡲ࡛ࡢ▱ぢࡼࡾ༡໭᪉ྥ࡟⣙ 2 ಸ㏆࠸⠊ᅖ࡟㸪㯮Ⰽᆺࡀ⏕ᜥࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸦ᕥᅗ㸧㸬௒ᚋࡣ᭦࡟⥳Ⰽᆺ࡜㯮Ⰽᆺࡀ᥋ࡋ࡚࠸ࡿᆅᇦࢆ᥈⣴ࡋ㸪ࡑࡢᆅᇦࡢయⰍᆺ㛫ࡢ⾜ືᐇ㦂ࡸ஺㓄ᐇ㦂ࢆຍ࠼ࡿ஦࡛㸪᫂░࡞యⰍ
2 ᆺࡀ⥔ᣢࡉࢀ࡚࠸ࡿ࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍࡿ㸬ᅗ 2 ࢧࢵ࣏ࣟࣇ࢟ࣂࢵࢱࡢ㯮Ⰽᆺࡢண᝿ศᕸᇦ㸬㯮࠸ᅄゅࡣ␃ⴌᕷ࿘㎶ࡢ≉␗࡞యⰍኚ␗㞟ᅋ࡜⪃࠼ࡽࢀ࡚࠸ࡓ᫬ࡢศᕸᇦ㸬⅊Ⰽࡢᅄゅᙧෆࡣᮏᖺ
ᗘࡢㄪᰝ࡛᫂░࡞㯮Ⰽᆺࢆ☜ㄆࡋࡓ⠊ᅖ㸬ᯟ⥺ෆࡣ㞳ᩓⓗ࡟㯮Ⰽᆺࡀぢࡽࢀศᕸࡢྍ⬟ᛶࡀ࠶ࡿ⠊ᅖ㸬
㸦Google My Map ࢆᘬ⏝㸧ᇶ┙◊✲㒊㛛 ␆⏘⛉Ꮫศศ㔝ᕝཎ Ꮫ
࣐࢘ࢫࡢึᮇ⬇ࡣ,᱓ᐇᮇࢆ⤒࡚⬇┙⬊ᮇ࡜࠸࠺ࢫࢸ࣮ࢪ࡟㐩ࡍࡿࠋ⬇┙⬊ᮇ⬇ࡣෆ㒊⣽⬊ሢ(ICM) ࡜ ᰤ 㣴 እ ⬇ ⴥ (TE) ࡟ ศ ໬ ࡋ ࡚ ࠸ ࡿࡀ,ICM/TE ศ໬࡟㔜せ࡞ࡢࡀ Hippo ࢩࢢࢼࣝࡢ࢚
ࣇ࢙ࢡࢱ࣮ᅉᏊ YAP1 ࡢ⣽⬊ෆᒁᅾ࡛࠶ࡿࠋ᱓ᐇ
ᮇࡢෆഃࡢ⣽⬊࡛ࡣ Hippo ࢩࢢࢼࣝࡀάᛶ໬ࡋ࡚
࠾ࡾ,YAP1 ࡣ⣽⬊㉁࡟ᒁᅾࡍࡿࡇ࡜࡛ ICM ࡟ศ໬ࡋ,እഃࡢ⣽⬊࡛ࡣ Hippo ࢩࢢࢼࣝࡀ୙άᛶ໬
ࡋ,YAP1 ࡣ᰾࡟ᒁᅾࡍࡿࡇ࡜࡛ TE ≉␗ⓗ㑇ఏᏊࡢ㌿෗ࢆಁ㐍ࡋ,TE ࡟ศ໬ࡍࡿࠋࡑࡇ࡛ Hippo ࢩࢢࢼࣝࡢୖὶᅉᏊ࡛࠶ࡿ NF2 ࡟╔┠ࡋࡓࠋNF2 ࡣ⣽⬊⭷࡜⣽⬊㦵᱁࡟⤖ྜ࠾ࡼࡧᯫᶫࡋ࡚࠾ࡾ,⭘⒆ᢚไᅉᏊ࡜ࡋ࡚ᗈࡃ▱ࡽࢀ࡚࠸ࡿࠋࡋ࠿ࡋ,ᇵ㣴య⣽⬊࡜␗࡞ࡾ,ึᮇ⬇࡟࠾ࡅࡿᙺ๭ࡣ࡯࡜ࢇ࡝᫂
ࡽ࠿࡟࡞ࡗ࡚࠸࡞࠸ࠋࡋࡓࡀࡗ࡚ᮏᖺᗘࡣ,ึᮇ⬇
Ⓨ⏕࡟࠾ࡅࡿ NF2 ࡢᙺ๭ࢆ᳨ドࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ㔝⏕ᆺ Nf2 ࡜⺯ගࢱࣥࣃࢡ㉁࡛࠶ࡿ GFP ࡢ DNA
ࢆ PCR ἲ࡟ࡼࡾ⼥ྜࡋࡓ (௨ୗ,Nf2WT-GFP) ࠋࡇࡢ Nf2WT-GFP ࢆ㗪ᆺ࡟ࡋ࡚ 1.⣽⬊⭷ᒁᅾ࡟㔜せ࡞ࢻ ࣓ ࢖ ࣥ ෆ ࡢ Leu ࢆ Pro ࡟ ⨨ ᥮ ࡋ ࡓ ኚ ␗ య(Nf2L64P-GFP) ,2.NF2 ࡢࣜࣥ㓟໬≧ែࢆไᚚࡍࡿ
518 ␒┠ࡢ Ser ࢆ Ala ࡟⨨᥮ࡋࡓ⬺ࣜࣥ㓟໬ኚ␗య(Nf2S518A-GFP) ,3.ྠ Ser ࢆ Glu ࡟⨨᥮ࡋࡓࣜࣥ㓟໬ኚ␗య (Nf2S518E-GFP)ࡢࢥࣥࢫࢺࣛࢡࢺࢆᵓ
⠏ࡋࡓࠋࡇࢀࡽࢥࣥࢫࢺࣛࢡࢺ࠿ࡽ mRNA ࢆయእ㌿෗ࡋ,࣐࢘ࢫ 2 ⣽⬊ᮇ⬇࡟ᑟධࡋࡓࠋᑐ↷༊࡜ࡋ
࡚ GFP ༢⊂ࡢ mRNA ࢆ⏝࠸࡚ࠊ᱓ᐇᮇ࡟࠾ࡅࡿ
NF2 ࡢᒁᅾࢆඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾࡛ㄪ࡭ࡓࠋࡲ
ࡓࠊYAP1 ᢠయ࡛ච␿ᰁⰍࢆᐇ᪋ࡋ,ྠᵝ࡟ Hippoࢩࢢࢼࣝࡢάᛶ≧ែ࡬ࡢᙳ㡪ࢆㄪ࡭ࡓࠋ
ࡲࡎ NF2WT-GFP ࡢ⣽⬊ෆᒁᅾࡣᇵ㣴య⣽⬊ࡢ㐣ཤࡢ▱ぢ࡜୍⮴ࡋ,⣽⬊⭷㏆ഐ࡛☜ㄆࡉࢀࡓࠋࣜࣥ 㓟 ໬ ≧ ែ ࡢ ␗ ࡞ ࡿ NF2S518A-GFP ࡜
NF2S518E-GFP ࡶྠᵝ࡟⣽⬊⭷㏆ഐ࡟ᒁᅾࡋ࡚࠾
ࡾ,NF2 ࡢࣜࣥ㓟໬ࡣ⣽⬊ෆᒁᅾ࡟ᙳ㡪ࢆ୚࠼࡞࠸
ࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋࡋ࠿ࡋ,NF2L64P-GFP ࡣ⣽⬊㉁඲య࡟ᒁᅾࡋ࡚࠾ࡾ,⣽⬊⭷㏆ഐ࡛ࡢᙉ࠸ࢩ
ࢢࢼࣝࡣ☜ㄆ࡛ࡁ࡞࠿ࡗࡓࠋYAP1 ࡢච␿ᰁⰍ࡛ࡣGFP,NF2WT-GFP ࡣඹ࡟㐣ཤࡢ▱ぢ࡜ྠᵝ࡟,ෆഃࡢ⣽⬊࡛⣽⬊㉁ ,እഃࡢ⣽⬊࡛᰾ᒁᅾࡔࡗࡓࠋ
NF2S518A-GFP ࡛ࡣእഃࡢ⣽⬊࡛ YAP1 ࡢ⣽⬊㉁ᒁᅾࡀ᰾࡜ྠ⛬ᗘࡲ࡛ቑຍࡋ࡚࠾ࡾ,Hippo ࢩࢢࢼࣝ ࡣ ά ᛶ ໬ ࡋ ࡚ ࠸ ࡓ ࠋ ㏫ ࡟ ,NF2S518E-GFP ࡜
NF2L64P-GFP ࡛ࡣෆഃࡢ⣽⬊࡛ YAP1 ࡀᙉࡃ᰾࡟
ᒁᅾࡋ࡚࠸ࡓࡇ࡜࠿ࡽ Hippo ࢩࢢࢼࣝࡣ୙άᛶ໬

− 21 −

ࡋ࡚࠸ࡓࠋ௨ୖࡢ⤖ᯝࡢ⫼ᬒ࡜ࡋ࡚ࠊAMOT ࡜࠸࠺ Hippo ࢩࢢࢼࣝ㛵㐃ศᏊ࡜ࡢ┦஫స⏝ࡀ⪃࠼ࡽ
ࢀࡿࠋNF2 ࡣ⣽⬊⭷ୖ࡛ AMOT ࡜⤖ྜࡍࡿࡇ࡜࡛
Hippo ࢩࢢࢼࣝࡀάᛶ໬ࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿ
ࡀ,ᇵ㣴య⣽⬊ࡢ▱ぢ࡛ࡣ NF2 ࡢ 518 ␒┠ࡢ Ser ࡀࣜࣥ㓟໬ࡉࢀ࡚࠸ࡿࡇ࡜࡛ AMOT ࡜ࡢ⤖ྜࡀ㜼ᐖࡉࢀࡿࡇ࡜ࡶሗ࿌ࡉࢀ࡚࠸ࡿࠋࡋࡓࡀࡗ
࡚,NF2S518E-GFP,NF2L64P-GFP ࡣ࠸ࡎࢀࡶ⣽⬊⭷ୖ࡛ࡢ AMOT ࡜ࡢ⤖ྜࡀ㜼ᐖࡉࢀࡓࡇ࡜࡛
Hippo ࢩࢢࢼࣝࡀ୙άᛶ໬ࡋࡓ࡜᥎ᐹࡉࢀࡓࠋ௨
ୖࡼࡾ㸪࣐࢘ࢫࡢึᮇ⬇Ⓨ⏕࡟࠾࠸࡚ NF2 ࡣ⣽⬊⭷࡟ᒁᅾࡋ࡚࠸ࡿ≧ែ࡛ࠊࣜࣥ㓟໬≧ែࡢኚ໬࡟
ࡼࡾ Hippo ࢩࢢࢼࣝࡢάᛶࢆไᚚࡋ࡚࠸ࡿࡇ࡜ࡀ
♧၀ࡉࢀࡓࠋ
ㄽᩥⓎ⾲
Kohri N, Akizawa H, Iisaka S, Bai H, Yanagawa Y,
Takahashi M, Komatsu M, Kawai M, Nagano M,
Kawahara M. Trophectoderm regeneration to support
full-term development in the inner cell mass isolated
from bovine blastocyst.
Journal of Biological
Chemistry. 2019; 294(50): 19209-19223.

኱Ꮫ㝔ᩍ⫱Ꮫ◊✲㝔ᩍ⫱Ꮫ㒊㛛 ೺ᗣయ⫱Ꮫศ㔝ᒣ௰ ຬ஧㑻◊✲ࢸ࣮࣐⏕≀᫬ィ࡟ࡼࡿ⾜ືࣜࢬ࣒ࡢᨭ㓄ᵝᘧ࡜⾜ືࣜࢬ࣒࠿ࡽ୰ᯡ᫬ィ࡬ࡢࣇ࢕࣮ࢻࣂࢵࢡᶵᵓࡢゎ᫂ ᙜ◊✲ᐊ࡛ࡣࠊ⩦័ⓗ࡞㐠ືࡀᴫ᪥ࣜࢬ࣒ࡢⓎ᣺୰ᯡ࡛࠶ࡿどᗋୗ㒊ど஺ཫୖ᰾(Suprachiasmatic
nucleus: SCN)࡟ᑐࡋ࡚࡝ࡢࡼ࠺࡟స⏝ࡋࠊᮎᲈ⮚ჾࡢᴫ᪥ࣜࢬ࣒࠾ࡼࡧ⾜ືࣜࢬ࣒࡟୚࠼ࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿ◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋR2 ᖺᗘࡣࠊ᫬ィ㑇ఏᏊ Period1 ࡢࣉ࣮ࣟࣔࢱ࣮ୗὶ࡟࣍ࢱࣝࡢⓎගࢱࣥࣃࢡ㉁ Luciferase 㑇ఏᏊࢆᑟධࡋࡓࢺࣛࣥ
ࢫࢪ࢙ࢽࢵࢡ࣐࢘ࢫ㸦Period1-luc ࣐࢘ࢫ㸧ࢆ⏝࠸࡚௨ୗࡢᐇ㦂ࢆ⾜ࡗࡓࠋ࣐࢘ࢫࡣࠊᅇ㌿㍯ࡀࡘ࠸࡚࠸࡞࠸ࢣ࣮ࢪ࡛ಶู࡟㣫⫱ࡋࠊ24 ᫬㛫࿘ᮇࡢ᫂ᬯࢧ࢖ࢡࣝ(LD)࡛ 2 㐌㛫ࠊ࣐࢘ࢫࡢ⮬Ⓨ⾜ືࣜࢬ࣒ࢆ ᐃࡋࡓᚋࠊᜏᖖᬯ⎔ቃ(constant darkness:
DD1)࡛ 4 㐌㛫⾜ືࣜࢬ࣒ࢆࣇ࣮ࣜࣛࣥࡉࡏࡓࠋࡑ
ࡢᚋࠊᜏᖖᬯ⎔ቃୗ࡛࣐࢘ࢫ࡟㍯ᅇࡋ㐠ື(Newcage with a running-wheel: NCRW)ࢆ 1 ᪥ 3 ᫬㛫ࠊ24
᫬㛫࿘ᮇ࡛㈇Ⲵࡋࠊ⾜ືࣜࢬ࣒ࡀ㍯ᅇࡋ㐠ືࢫࢣࢪ࣮ࣗࣝ࡟ྠㄪࡋࡓࡢࢆ☜ㄆࡋࡓᚋࠊ෌ࡧᜏᖖᬯ
࡛ࣇ࣮ࣜࣛࣥࡉࡏࡓ(DD2) (ྑᅗ: Per1-luc ࣐࢘ࢫ⾜ືࣜࢬ࣒ࡢ ᐃ౛)ࠋ⩦័ⓗ࡞㍯ᅇࡋ㐠ືࡀ⏕≀᫬ィࡢ㝵ᒙᵓ㐀㸦୰ᯡ᫬ィࠊᮎᲈ᫬ィࠊ⾜ືࣜࢬ࣒㸧࡟୚࠼ࡿᙳ㡪ࢆ᳨ドࡍࡿࡓࡵࠊLDࠊDD1ࠊ
NCRWࠊ

DD2 ࡛ Per1-luc ࣐࢘ࢫ࠿ࡽ⬻࠾ࡼࡧᮎᲈ⤌⧊(⫢⮚ࠊ㦵᱁➽)ࢆ᥇ྲྀࡋࡓࠋ࣐࢘ࢫࡢど஺ཫୖ᰾ࡣ๓ᚋ㛗ࡀ⣙ 500-600μm ࡛࠶ࡾࠊ࿀ഃ㒊࡜ᑿഃ㒊࡛ࡣ␗࡞ࡿᶵ⬟ࢆࡶࡘࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡑࡇ࡛ࠊᮏ
ᐇ㦂࡛ࡣࠊSCN ࡢ࿀ഃ㒊 or ᑿഃ㒊ࢆྵࡴ 150μm
ࡢෙ≧᩿ษ∦ࢆసᡂࡋࠊPer1-luc ࣜࢬ࣒ࢆ ᐃࡋࡓࠋࡲࡓࠊᦤ㣗࣭╧╀ぬ㓰࡟㛵ࢃࡿ⬻㒊఩࡛࠶ࡿᘪ≧᰾(Arcuate Nucleus: ARC)ࠊ⫢⮚ࠊ⭡┤➽ࡢ
Per1-luc ࣜࢬ࣒ࢆ ᐃࡋࡓࠋ௒ᚋࠊྛ᮲௳࡛ ᐃࡋࡓ⾜ືࣜࢬ࣒࡜ SCN(࿀ഃࠊᑿഃ)ࠊARCࠊ⫢⮚ࠊ⭡┤➽ࡢ Per-1luc ࣜࢬ࣒ࡢ఩┦㛵ಀ(᫬㛫㛵ಀ)ࡢ
ゎᯒࡋࠊ⩦័ⓗ࡞㐠ືࡀ⏕≀᫬ィࡢᅇ๰㐀࡟୚࠼ࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡋ࡚࠸ࡁࡓ࠸ࠋ

኱Ꮫ㝔ᕤ
ᕤᏛ◊✲㝔
ᛂ⏝≀⌮Ꮫ㒊㛛 㔞Ꮚ≀ᛶᕤᏛศ㔝୹⏣ ⪽㸦⣧Ỉ฼⏝㸧Ꮫ⾡ㄽᩥ
Yasuzuka, S., Uji, S., Sugiura, S., Terashima, T.,
Nogami, Y., Ichimura, K., and Tanda, S. (2019)"Highly Isotropic In-plane Upper Critical Field in the
Anisotropic s-Wave Superconductor 2H -NbSe2",
Journal of Superconductivity and Novel Magnetism
33: 953-958 (2020).
Ꮫ఍Ⓨ⾲ᶓ஭༓⇊㸪ᐑᔘ୍ㄔ㸪㔠஭ᜤభ㸪ᕷᮧ᫭୍㸪୹⏣⪽㸪ᯇỌᝅ᫂㸪㯮⃝ᚭ㸸Fe1+xTe ࡢㄏ㟁⋡ ᐃ㸬᪥ᮏ≀⌮Ꮫ఍➨ 75 ᅇᖺḟ኱఍㸪2020 ᖺ 3 ᭶ 16-19 ᪥㸪ྡྂᒇ኱Ꮫᮾᒣ࢟ࣕࣥࣃࢫ㸦ྡྂᒇᕷ㸧㸬ᶓ஭༓⇊㸪ᐑᔘ୍ㄔ㸪㔠஭ᜤభ㸪ᕷᮧ᫭୍㸪୹⏣⪽㸪ᯇỌᝅ᫂㸪㯮⃝ᚭ㸸Fe1+xTe ࡢㄏ㟁⋡ ᐃ II㸬᪥ᮏ≀⌮Ꮫ఍➨ 2020 ᖺ⛅Ꮨ኱఍㸪
2020 ᖺ 9 ᭶ 8-11᪥㸪࢜ࣥࣛ࢖ࣥ㸬࢚ࢿࣝࢠ࣮⎔ቃࢩࢫࢸ࣒㒊㛛ᛂ⏝࢚ࢿࣝࢠ࣮ࢩࢫࢸ࣒ศ㔝⏣㒊 ㇏㸦⣧Ỉ฼⏝㸧Ⓨ⾲ㄽᩥす⏣ᑦຌ㸪⏣㒊㇏㸪ၿᙜဴஓ㸪᪥ཎ㣁ஓ㸪㏆ஂṊ
⨾ (2020) ࣞࢻࢵࢡࢫࣇ࣮ࣟ㟁ụ࡟࠾ࡅࡿᵓ㐀࣭㐠㌿᮲௳ᙳ㡪ࡢ㞟⣙୺せᅉᏊࢆ⏝࠸ࡓᛶ⬟ホ౯㸬᪥ᮏᶵᲔᏛ఍ㄽᩥ㞟㸪86 ᕳ 888 ྕ㸪
20-00108: 1-13㸬
Ꮫ఍Ⓨ⾲᪥ཎ 㣁ஓ㸪す⏣ ᑦຌ㸪⏣㒊 ㇏㸸ࣞࢻࢵࢡࢫ
ࣇ࣮ࣟ㟁ụ࡟࠾ࡅࡿᛶ⬟ᦆኻせᅉࡢᐇ㦂ⓗホ౯㸬
➨ 57 ᅇ᪥ᮏఏ⇕ࢩ࣏ࣥࢪ࣒࢘㸪2020 ᖺ 6 ᭶㸦ㅮ
₇ㄽᩥ㞟ࡢࡳ㸧㸬

− 22 −

᭷⃝ ្⣖㸪⏣㒊 ㇏㸸PEFC ࢞ࢫᣑᩓᒙࡢ⾲㠃ぶỈฎ⌮࡟ࡼࡿỈ᤼ฟ࡜㟁ụᛶ⬟ࡢᨵၿ㸬➨ 57 ᅇ᪥ᮏఏ⇕ࢩ࣏ࣥࢪ࣒࢘㸪2020 ᖺ 6 ᭶㸦ㅮ₇ㄽᩥ㞟ࡢࡳ㸧㸬ᖹ஭ ㈼㸪⏣㒊 ㇏㸸Ỉ㍺㏦⌧㇟ࢆ⪃៖ࡋࡓ PEFC
ịⅬୗ㉳ື≉ᛶྥୖ㸬➨ 57 ᅇ᪥ᮏఏ⇕ࢩ࣏ࣥࢪ࢘
࣒㸪2020 ᖺ 6 ᭶㸦ㅮ₇ㄽᩥ㞟ࡢࡳ㸧㸬▮⏣ ῱భ㸪⏣㒊 ㇏㸸㓟⣲㍺㏦᢬ᢠపῶࢆ┠ᣦࡋࡓ PEFC ࢢࣛࣇ࢙ࣥゐ፹ᒙ࡟㛵ࡍࡿ᳨ウ㸬➨ 57
ᅇ᪥ᮏఏ⇕ࢩ࣏ࣥࢪ࣒࢘㸪2020 ᖺ 6 ᭶㸦ㅮ₇ㄽᩥ㞟ࡢࡳ㸧㸬ᖹ஭ ㈼㸪᳜ᮧ ㇦㸪⏣㒊 ㇏㸸Ỉ㍺㏦࣭෾⤖⌧㇟ࡀ PEFC ịⅬୗ㉳ື᫬ࡢࢻࣛ࢖࢔࢘ࢺ࠾ࡼࡧຎ
໬࡟ཬࡰࡍᙳ㡪㸬᪥ᮏᶵᲔᏛ఍⇕ᕤᏛࢥࣥࣇ࢓ࣞ
ࣥࢫ㸪2020 ᖺ 10 ᭶ 10 ᪥㸪໭ᾏ㐨኱Ꮫ㸦ᮐᖠᕷ㸦࢜
ࣥࣛ࢖ࣥ㸧
㸧
㸬
Zhan, J., Uemura, S., and Tabe, Y.㸸Effect of Generated
Water on Power Increase after PEFC Cold Startup㸬᪥ᮏᶵᲔᏛ఍⇕ᕤᏛࢥࣥࣇ࢓ࣞࣥࢫ㸪2020 ᖺ 10 ᭶
10 ᪥㸪໭ᾏ㐨኱Ꮫ㸦ᮐᖠᕷ㸦࢜ࣥࣛ࢖ࣥ㸧㸧㸬▮⏣ ῱భ㸪᳜ᮧ ㇦㸪⏣㒊 ㇏㸸PEFC ゐ፹ᒙ࡬ࡢࢢࣛࣇ࢙ࣥᑟධ࡟ࡼࡿ࢔࢖࢜ࣀ࣐࣮ࣇ࣮ࣜ໬࡜
㓟⣲㍺㏦᢬ᢠホ౯㸬᪥ᮏᶵᲔᏛ఍⇕ᕤᏛࢥࣥࣇ࢓
ࣞࣥࢫ㸪2020 ᖺ 10 ᭶ 11 ᪥㸪໭ᾏ㐨኱Ꮫ㸦ᮐᖠᕷ㸦࢜ࣥࣛ࢖ࣥ㸧㸧㸬᭷⃝ ្⣖㸪᳜ᮧ ㇦㸪⏣㒊 ㇏㸸PEFC ࢞ࢫᣑᩓᒙࡢ⾲㠃ぶỈฎ⌮࡟ࡼࡿⓎ㟁ᛶ⬟ྥୖ࡜Ỉ᤼ฟ࣓࢝ࢽࢬ࣒㸬᪥ᮏᶵᲔᏛ఍⇕ᕤᏛࢥࣥࣇ࢓ࣞࣥࢫ㸪2020 ᖺ 10 ᭶ 11 ᪥㸪໭ᾏ㐨኱Ꮫ㸦ᮐᖠᕷ㸦࢜ࣥࣛ࢖ࣥ㸧㸧㸬኱Ꮫ㝔་Ꮫ◊✲㝔㝔་ṑᏛ⥲ྜ◊✲Ჷ ୰ኸ◊✲㒊㛛ᒣ㔝㎶ ㈗ಙ⚄⤒ᅇ㊰⌮ㄽ࡟ࡼࢀࡤ⣲Ꮚࡢฟຊ㛵ᩘࡢ≉ᛶ࡟౫Ꮡࡋࠊ᝟ሗ࢟ࣕࣜ࢔ࡀỴࡲࡿࠋࢫࣃ࢖ࢡࡣ⚄⤒⣽⬊ࡀ㐣Ώ≧ែ࡟࠶ࡿ࡜ࡁ࡟⏕ࡌࡿࡓࡵࠊࢫࣃ࢖
ࢡ⏕ᡂࡣ㐣ཤࡢ⚄⤒άື࡟౫Ꮡࡍࡿࡇ࡜ࡀሗ࿌ࡉ
ࢀ࡚࠸ࡿ㸦Segundo et al.Neuroscience 1994, Yamanobe
et al. Biosystems 1998㸧ࠋࡲࡓࠊ⚄⤒⣽⬊ࡣࠊᣑᩓ㐣⛬࡛㏆ఝࡉࢀࡿ࢖࢜ࣥࢳࣕࢿࣝࣀ࢖ࢬࠊࢩࢼࣉࢫ
ᑠ⬊ࡢ⮬Ⓨⓗᨺฟ࡟ࡼࡿࢪࣕࣥࣉࣀ࢖ࢬ࡞࡝ࢆᣢ
ࡘ☜⋡ⓗ࡞ᣲືࢆࡍࡿ⣲Ꮚ࡛ࡶ࠶ࡿࠋࡇࢀࡽࡢࣀ
࢖ࢬ࡟ࡼࡾ⚄⤒⣽⬊ࡢᛂ⟅≉ᛶࡀኚࢃࡿࡇ࡜ࡶண
᝿ࡉࢀࡿࠋࡑࡇ࡛ࠊྛ⚄⤒⣽⬊࡟࠾࠸࡚㐣Ώᛂ⟅≉ᛶ࡜ࣀ࢖ࢬࡢᙳ㡪ࢆ཯ᫎࡋࡓฟຊ㛵ᩘࡢ≉ᛶࢆᐇ㦂ⓗ࡟ồࡵࡿࡇ࡜ࡀࠊ᝟ሗ࢟ࣕࣜ࢔ࢆゎ᫂ࡍࡿࡓࡵ࡟ᚲせ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿࠋᐇ㦂࡛⚄⤒⣽⬊ࡢฟຊ㛵ᩘࢆㄪ࡭ࡿ᪉ἲࢆᵓ⠏ࡍࡿࡓࡵࠊ☜⋡ⓗ⚄⤒⣽⬊ࣔࢹࣝࡢⓎⅆάືࡀ࡝ࡢࡼ࠺࡞☜⋡㐣⛬࡛࠶ࡿ࠿▱ࡿࡇ࡜ࡀ㔜せ࡛࠶ࡿࠋ≉࡟ࠊ☜⋡㐣⛬
ࡢᛶ㉁ࢆỴࡵࡿ᥎⛣☜⋡ᐦᗘࡢィ⟬࠾ࡼࡧࡑࡢホ౯ࡀ㔜せ࡜࡞ࡾࠊࡇࢀࢆ✺◚ཱྀ࡟ࡋ࡚⚄⤒⣽⬊ࣔࢹࣝࡢ⏕⌮Ꮫⓗ࡞ᣦᶆࡀィ⟬࡛ࡁࡿࡼ࠺࡟࡞ࡿࠋ
ࡇࡢࡼ࠺࡞ၥ㢟ព㆑ࡢࡶ࡜ࠊ௒ᖺᗘࡣ௨ୗࡢ㸰ࡘࡢࢸ࣮࣐࡟㛵ࡋ࡚◊✲ࢆᐇ᪋ࡋࡓࠋ
1. ࡇࢀࡲ࡛ Stuart-Landau ᪉⛬ᘧ࡟☜⋡㡯ࢆຍ࠼ࡓࣔࢹࣝ㸦☜⋡ⓗ Stuart-Landau ᪉⛬ᘧ㸧ࡢࡼ࠺࡟ࠊ
ẚ㍑ⓗᢅ࠸ࡸࡍ࠸ᩘ⌮ࣔࢹࣝࢆ⏝࠸ࡑࡢᣲືࢆㄪ
࡭࡚ࡁࡓࠋ௒ᖺᗘࡣࠊࡉࡽ࡟ࠊ୍⯡ࡢ⚄⤒⣽⬊ࣔࢹࣝࡢධฟຊ≉ᛶࢆㄪ࡭ࡿࡓࡵࠊ☜⋡㡯ࢆຍ࠼ࡓ☜ ⋡ ⓗ FitzHugh-Nagumo ࣔ ࢹ ࣝ ࠾ ࡼ ࡧ ☜ ⋡ ⓗMorris-Lecar ࣔࢹࣝࢆ⏝࠸ࡓࠋ☜⋡ⓗ Stuart-Landau᪉⛬ᘧࡢሙྜࠊ௒ᅇྲྀࡾ⤌ࢇࡔࣔࢹࣝ࡜ẚ࡭㠀⥺ᙧᛶࡀ✜ࡸ࠿࡞ࡢ࡛ࠊ᥎⛣☜⋡ᐦᗘࢆ₞㏆ᒎ㛤࡛
㏆ఝࡋࠊࡑࡢ➨୍㡯࡛࠶ࡿ࢞࢘ࢫ㛵ᩘࢆ⏝࠸ࡓ㏆ఝ࡛ࡶ༑ศ࡟ࡑࡢ⤫ィⓗ኱ᇦᣲືࢆᤊ࠼ࡿࡇ࡜ࡀ
࡛ࡁࡓࠋࡋ࠿ࡋࠊ☜⋡ⓗ FitzHugh-Nagumo ࣔࢹࣝࡸ☜⋡ⓗ Morris-Lecar ࣔࢹࣝࡢሙྜࡣࠊάື㟁఩ࡀ㉳ࡇࡿ࠿࡝࠺࠿ࢆỴࡵࡿ㜈್௜㏆ࡢࢲ࢖ࢼ࣑ࢡ
ࢫࡀཎᅉ࡛ࠊ₞㏆ᒎ㛤➨୍㡯ࢆ⏝࠸ࡓ㏆ఝ࡛ࡣࣔࢹࣝࡢ⤫ィⓗ኱ᇦᣲືࢆᤊ࠼ࡁࡿࡇ࡜ࡀ࡛ࡁ࡞࠸
ࡇ࡜ࡀศ࠿ࡗࡓࠋࡑࡇ࡛ࠊ₞㏆ᒎ㛤ἲࡢ㧗ḟࡢ㡯ࡲ࡛ィ⟬ࡋࠊ᥎⛣☜⋡ᐦᗘࡢ㏆ఝࢆヨࡳࡓࠋࡉࡽ
࡟ࠊ࢖࢝㍈⣴ࢫࣃ࢖ࢡิࢹ࣮ࢱ࠿ࡽᚓࡽࢀࡿ᝟ሗ
࡜᥎⛣☜⋡ᐦᗘࢆ࡝ࡢࡼ࠺࡟⤖ࡧࡘࡅࡿ࠿᳨ウࡋࡓࠋ
2. ₞㏆ᒎ㛤࡟ࡼࡿ᥎⛣☜⋡ᐦᗘࡢ㏆ఝ⢭ᗘࢆ᭱ᑠ஧஌ㄗᕪ࡛ᐃ㔞໬ࡍࡿࡓࡵࠊ₞㏆ᒎ㛤࡟ࡼࡿࡶࡢ࡜ࠊࣔࣥࢸ࢝ࣝࣟࢩ࣑࣮ࣗࣞࢩࣙࣥ࡟ࡼࡿ᥎⛣☜⋡ᐦᗘࡢᐦᗘẚࡀᚲせ࡟࡞ࡿࠋ⣲ᮔ࡞Ⓨ᝿࡛ࡣ₞㏆ᒎ㛤࡟ࡼࡿ᥎⛣☜⋡ᐦᗘ࡜ࣔࣥࢸ࢝ࣝࣟࢩ࣑
࣮ࣗࣞࢩࣙࣥ࡟ࡼࡿ᥎⛣☜⋡ᐦᗘࡢࡑࢀࡒࢀࡢࢧ
ࣥࣉࣝ࠿ࡽᐦᗘ㛵ᩘࢆ⏝࠸ࠊ᭱ᑠ஧஌ㄗᕪࢆィ⟬ࡍࡿࡇ࡜࡟࡞ࡿࠋࡋ࠿ࡋࠊᮡᒣ㸦⤫ィᩘ⌮ࠊ2010㸧ࡀᣦ᦬ࡍࡿࡼ࠺࡟ࠊ☜⋡ᐦᗘࡢ᥎ᐃࡣᅔ㞴࡞ၥ㢟࡛࠶ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊࡇࢀࢆᅇ㑊ࡍࡿࡇ࡜ࡀᮃࡲࡋ࠸ࠋࡑࡇ࡛ᡃࠎࡣᮡᒣ㸦⤫ィᩘ⌮ࠊ2010㸧ࡽࡀᥦ᱌ࡋࡓࠊಶࠎࡢ☜⋡ᐦᗘࡢ᥎ᐃࢆᅇ㑊ࡋᐦᗘẚࢆ᥎ᐃࡍࡿ᪉ἲࢆ⏝࠸ࠊ᭱ᑠ஧஌ㄗᕪࢆィ⟬ࡋࠊ₞㏆ᒎ㛤࠿ࡽᚓࡽࢀࡿ᥎⛣☜⋡ᐦᗘࡢ⢭ᗘࢆ
ホ౯ࡋࡓࠋ

Ꮫ఍Ⓨ⾲
1. Takanobu Yamanobe㸪Approximation of transition
density of the conductance based neuronal modelwith noise 㸪➨ 58 ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍㸪− 23 −

2020 ᖺ 9 ᭶ 16 ᪥㹼9 ᭶ 18 ᪥㸪G ࣓ࢵࢭ⩌㤿㸦࢜ࣥࣛ࢖ࣥ㛤ദ㸧㸪⩌㤿
2. T. Yamanobe, Approximation of transition density of
the Morris-Lecar model including a diffusion term,
12th FENS Forum of Neuroscience, July 11-15, Belin(online), (2020)኱Ꮫ㝔ᩥᏛ◊✲㝔㝔ே㛫⛉Ꮫ㒊㒊㛛 ᚰ⌮Ꮫศศ㔝࿴⏣ ༤⨾◊✲ࢸ࣮࣐㸯
⮯⣲⣔㞴⇞๣ࢹ࢝ࣈࣟࣔࢴࣇ࢙ࢽ࣮࢚࣮ࣝࢸࣝ
㸦BDE-209㸧㸧ࡀࣛࢵࢺࡢ♫♫఍ᛶⓎ㐩࡟ཬࡰࡍᙳ㡪⮯⣲⣔㞴⇞๣ BDE-209 ࡣྍ⇞≀ࢆ⇞࠼࡟ࡃࡃࡋࠊ
ⅆ⅏ࡢᘏ↝ࢆ㜵ࡄࡇ࡜ࡀ࡛ࡁࡿࠋࡋ࠿ࡋ⬻⚄⤒⣔ࡢⓎ㐩࡟ᚲ㡲ࡢ⏥≧⭢࣍ࣝࣔࣥࢆ᧠஘ࡍࡿࡇ࡜࠿
ࡽࠊㄆ▱ᶵ⬟ࡢⓎ㐩ࢆ㜼ᐖࡍࡿྍ⬟ᛶࡀᣦ᦬ࡉࢀ
࡚࠸ࡿࠋࡑࡇ࡛ዷፎࣛࢵࢺ࡟ BDE-209 ࢆᢞ୚ࡋࠊ
ฟ⏕ࡋࡓࣛࢵࢺࡢ㉸㡢Ἴࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ࡜
BDE-209 ࡢస⏝ᶵᗎࢆ᫂ࡽ࠿࡟ࡍࡿ◊✲ࢆ⾜ࡗࡓࠋ᪉ἲ㸸ዷፎ 15 ᪥㹼ฟ⏘ᚋ 21 ᪥┠ࡲ࡛ࠊẕࣛࢵࢺ࡟ BDE-209 ࢆᦤྲྀࡉࡏࡓࠋᢞ୚㔞ࡣ 0㸦⤫ไ⩌㸧ࠊ
500mg/kg/day㸦పᢞ୚⩌㸧ࠊ1000mg/kg/day㸦㧗ᢞ୚⩌㸧࡜ࡋࡓࠋ⏕ᚋ 4ࠊ7ࠊ10ࠊ13ࠊ16ࠊ19ࠊ22 ᪥┠࡟ங௘ࣛࢵࢺࢆẕᏊศ㞳ࡋࠊ㉸㡢ἼⓎኌࢆ 5 ศ㛫ᐃࡋࡓࠋ⏕ᚋ 22 ᪥┠࡟㞳ஙࡉࡏ࡚ಶู㣫⫱ࡋࡓࠋ⏕ᚋ 43㹼45 ᪥┠ࡢ 3 ᪥㛫ࠊ㧗ᢞ୚⩌࡜⤫ไ⩌ࡑࢀࡒࢀࡢ⩌ෆ࡛ྠᛶ࣭ྠ⭡ࡢ 3 ༉ࢆ 1 ࡘࡢࢣ࣮ࢪ࡟
ධࢀ࡚ 15 ศ㛫ࡢ௰㛫㐟ࡧࢆ⾜࠸ࠊື⏬ࢆ㘓⏬ࡋࡓࠋࡲࡓ⏕ᚋ 32㹼34 ᪥┠࡟᥇⾑ࢆ⾜࠸ࠊ⬻࡜⫢⮚ࡶ᥇ྲྀࡋࡓࠋ⤖ᯝ࡜⪃ᐹ㸸BDE-209 ࡟᭚㟢ࡉࢀࡓங௘ࣛࢵࢺࡣࠊẕぶࡢὀពࢆᘬࡃ࿘ἼᩘኚㄪᆺࡢⓎኌࢆῶᑡࡉࡏ
ࡓࠋBDE-209 ࡣពᛮఏ㐩ᶵ⬟ࢆపୗࡉࡏࠊங௘ࣛ
ࢵࢺࡢ⏕Ꮡࢆ⬣࠿ࡍྍ⬟ᛶࡀ࠶ࡿࠋᛮ᫓ᮇࣛࢵࢺ
ࡢ௰㛫㐟ࡧ࡛ࡣ୙ᛌ࡞᝟ືࢆ♧ࡍⓎኌࡀቑຍࡋࠊ
⃭ࡋ࠸ᨷᧁᛶࢆ♧ࡍ boxingࠊwrestlingࠊpinning ࡀῶᑡࡋࡓࠋࡇࢀࡽࡢ⤖ᯝࡣ୍㈏ࡋ࡚ࠊBDE-209 ࡀࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࢆ௓ࡋࡓ♫఍ⓗ┦஫⾜ືࢆ㜼ᐖࡍࡿࡇ࡜ࢆ♧ࡋ࡚࠸ࡿࠋ 㧗ᢞ୚⩌࡛ࡣ⬻ෆ⚄⤒ఏ㐩≀㉁ࢭࣟࢺࢽࣥࡀቑ
ຍࡋࡓࠋࢭࣟࢺࢽࣥࡣ᝟ືࡸᨷᧁᛶࡢㄪᩚ࡟㛵ࢃࡗ࡚࠾ࡾࠊࢭࣟࢺࢽࣥࡀቑຍࡍࡿ࡜௰㛫㐟ࡧ⾜ືࡣᢚไࡉࢀࡿࡇ࡜ࡀ♧ࡉࢀ࡚࠸ࡿࠋBDE-209 ࡣࢭࣟࢺࢽࣥ࡟స⏝ࡋ࡚௰㛫㐟ࡧࢆ㜼ᐖࡋࠊ୙ᛌ࡞᝟
ື≧ែࢆᘬࡁ㉳ࡇࡋ࡚ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ࡟ࡶᙳ
㡪ࡍࡿ࡜⪃࠼ࡽࢀࡿࠋ

◊✲ࢸ࣮࣐㸰
ࣄࢺᆺ⮬㛢⑕ࣔࢹ࣐ࣝ࢘ࢫࡢ㉸㡢Ἴࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ ⮬㛢⑕ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖࡢᝈ⪅࡟ࡣࠊ௚⪅࡜ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࡀ࠺ࡲࡃ࡛ࡁ࡞࠸࡞࡝ࡢ㞀ᐖࡀㄆࡵࡽࢀࡿࠋ㑇ఏᏊࡢኚ␗ࡀཎᅉࡢ୍ࡘ࡜⪃࠼ࡽࢀ࡚࠸ࡿࡇ࡜࠿ࡽࠊࣄࢺ࡜ྠᵝࡢ㑇ఏᏊኚ␗ࢆ
࣐࢘ࢫ࡛෌⌧ࡋ࡚ࣔࢹࣝື≀ࢆస〇ࡋࠊ⮬㛢⑕ࡢ
Ⓨ⑕࣓࢝ࢽࢬ࣒ࡸ⑓ែࢆゎ᫂ࡍࡿ◊✲ࡀ㐍ࢇ࡛࠸ࡿࠋᮏ◊✲࡛ࡣ 15 ␒ᰁⰍయ q11-13 ࡀ㔜」ࡍࡿ࣐
࢘ࢫࢆᑐ㇟࡟ࠊ♫఍ⓗሙ㠃࡛ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙ
ࣥࢆ◊✲ࡋࡓࠋ
᪉ἲ㸸⿕᳨యࡣ⏕ᚋ⣙ 7 ࢝᭶㱋ࡢ㞤࣐࢘ࢫ
㸦C57BL6/J㸧࡛ࠊᒃఫ⪅㸫౵ධ⪅ࣃࣛࢲ࢖࣒ࢆ⏝࠸࡚㔜」ࢆᣢࡓ࡞࠸࣡࢖ࣝࢻᆺ࣌࢔㸦n=5㸧ࠊ∗ぶ⏤᮶ࡢ㔜」ࢆᣢࡘ࣊ࢸࣟᆺ࣌࢔㸦n=6㸧ࡢ㉸㡢Ἴࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࢆ ᐃࡋࡓࠋᒃఫ⪅㸫౵ධ⪅ࣃࣛࢲ࢖࣒࡛ࡣࠊ࣌࢔ࡢ୍᪉㸦ᒃఫ⪅㸧ࡀ㣫⫱ࡉࢀ࡚࠸ࡿࢣ࣮ࢪ࡟ࠊࡶ࠺୍᪉ࡢ࣐࢘ࢫ㸦౵ධ⪅㸧ࢆ
ධࢀࡿࠋ㏻ᖖࠊᒃఫ⪅ࡢ᪉ࡀ౵ධ⪅ࡼࡾඃ఩࡜࡞
ࡾࠊ౵ධ⪅㸦ຎ఩㸧ࢆጾᅽࡋࡓࡾᨷᧁࡋࡓࡾࡍࡿࠋ
ᮏ◊✲࡛ࡣ 1 ᪥ 1 ᅇ 10 ศ㛫㐃⥆ 10 ᪥㛫ࠊᒃఫ⪅㸫౵ධ⪅ࣃࣛࢲ࢖࣒ࢆ⾜ࡗࡓࠋ⤖ᯝ࡜⪃ᐹ㸸㉸㡢Ἴࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࢆゎᯒࡋࡓ࡜ࡇࢁࠊ࣊ࢸ࣭ࣟ࣌࢔ࡣ short ᆺⓎኌ㸦㛗ࡉࡀ
15 ࣑ࣜ⛊௨ୗ㸧ࡀቑຍࡋࠊdown ᆺⓎኌ㸦Ⓨኌ୰࡟
2kHz ௨ୖ࿘Ἴᩘࡀపୗ㸧ࡀῶᑡࡋࡓࠋ࿘Ἴᩘࡀኚ
໬ࡋ࡞࠸ࣇࣛࢵࢺᆺࡢⓎኌࡸ 15 ࣑ࣜ⛊௨ୗࡢⓎኌࡶቑຍࡋࡓࠋࡉࡽ࡟ᒃఫ⪅㸫౵ධ⪅ࣃࣛࢲ࢖࣒
ࡢᚋ༙ 6,7,8,10 ᪥┠࡛ࡣࠊ࣊ࢸ࣭ࣟ࣌࢔ࡣ༢㡢⠇
ࡢⓎኌࡶቑຍࡋࡓࠋ࣊ࢸ࣭ࣟ࣌࢔ࡣ♫఍ⓗࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥሙ㠃࡛ࠊ༢㡢⠇࡛࿘Ἴᩘኚ໬ࡢ࡞࠸
ࣇࣛࢵࢺ࡞▷࠸Ⓨኌࢆ⾜࠺ࡇ࡜ࡀࢃ࠿ࡗࡓࠋࡇࡢ
ࡼ࠺࡞༢⣧࡞Ⓨኌࡣࠊ」ᩘࡢ㡢⠇࠿ࡽᵓᡂࡉࢀ࿘
Ἴᩘኚ໬ࢆక࠺Ⓨኌ㸦࿘ἼᩘኚㄪᆺⓎኌ㸧࡜ẚ㍑
ࡋ࡚ࠊ௚ಶయࡢὀពࡸ⯆࿡ࢆᘬࡁ࡟ࡃ࠸ࠋ15 ␒ᰁⰍయ q11-13 ࡀ㔜」ࡍࡿࡇ࡜࡛ࠊ♫఍ⓗࢥ࣑ࣗࢽࢣ
࣮ࢩࣙࣥ࡟ᨭ㞀ࡢ㉳ࡇࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡓࠋ ࠙Ꮫ఍Ⓨ⾲ࠚ
1. ᙇ 㡼ࠊ࿴⏣༤⨾㸬Effects of group housing on
chronic stress-induced emotional behavior infemale rats㸬➨ 6 ᅇ໭ᾏ㐨኱Ꮫ㒊ᒁᶓ᩿ࢩ࣏ࣥ
ࢪ࣒࢘㸪2020 ᖺ 10 ᭶ 19 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ㸬
2. ᮌ❧⯟㍜ࠊ࿴⏣༤⨾㸬ࣞࢪࢹࣥࢺ—࢖ࣥࢺ࣮ࣝ
ࢲ࣮ࣃࣛࢲ࢖࣒࡟࠾ࡅࡿࣄࢺᆺ⮬㛢⑕ࣔࢹ࣐ࣝ࢘ࢫࡢ㉸㡢Ἴࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ㸬➨ 6 ᅇ໭ᾏ㐨኱Ꮫ㒊ᒁᶓ᩿ࢩ࣏ࣥࢪ࣒࢘㸪2020 ᖺ 10 ᭶
19 ᪥㸪࢜ࣥࣛ࢖ࣥ㛤ദ㸬

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໭᪉⏕≀ᅪࣇ࢕࣮ࣝࢻ⛉Ꮫࢭࣥࢱ࣮
⏕≀ከᵝᛶ㡿ᇦ ᾏ⏘⸴㢮㐺ᛂᶵ⬟ศ㔝ᅄࢶ಴ ඾⁠㸦ᾏỈ฼⏝㸧Ⓨ⾲ㄽᩥ
Hu, Z.M., Shan, T.F., Zhang, J., Zhang, Q.S., Critchley,
A.T., Choi, H.G., Yotsukura, N., Liu, F.L., Duan, D.L.
(2020) Kelp aquaculture in China: a retrospective and future
Prospects. Aquaculture https://doi.org/10.1111/raq.12524.
Jie, Z., Yotsukura, N., Jueterbock, A., Hu, Z.M., Assis,J., Nagasato, C., Yao, J., and Duan, D. (2021)
Detecting no natural hybridization and predicting range
overlap in Saccharina angustata and Saccharina
japonica. Journal of Applied Phycology 33: 693-702.
Yotsukura, N., Unjo, K., Hashimoto, Y., Kawai, T., andKatsuyama, Y. (2021) Method for creating laminarialeankelp colonies using seawater that contains naturally
derived polymers. Regional Studies in Marine Science
https://doi.org/10.1016/j.rsma.2021.101663.
Ꮫ఍Ⓨ⾲⊦㔝༓ᑜ, ᫍ㔝㞞࿴, 㜿㒊๛ྐ, ᅄࢶ಴඾⁠,Klochkova, N., ᑠட୍ᘯ㸸໭ᾏ㐨⏘⣚⸴ࢡࢩ࣋ࢽࣄ
ࣂᒓ㸦Ptilota㸧ࡢ⣔⤫ศ㢮Ꮫⓗ◊✲. ᪥ᮏ⸴㢮Ꮫ఍➨ 45 ᅇ኱఍㸦࢜ࣥࣛ࢖ࣥᮾி࣭2021㸧, 2021 ᖺ 3 ᭶,ᮾிᾏὒ኱Ꮫ㸦ᮾி㒔 ༊㸧.

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ື≀ᰁⰍయඹ
ඹྠ฼⏝㒊㛛

− 27 −㑇 ఏᏊᐇ㦂ඹྠ฼⏝㒊㛛㛛  ᙜ㒊㛛࡛ࡣࠊ㑇ఏᏊ⤌ࡳ᥮࠼ᐇ㦂࡟ᚲせ࡞ࢡ࣮ࣜࣥ࣋ࣥࢳࡸᏳ඲࢟ࣕࣅࢿࢵࢺ➼ࡢタഛࢆഛ࠼࡚࠾ࡾࠊ⥅⥆ⓗ࡟ά⏝ࡉࢀ࡚ࡁࡲࡋࡓࠋ㑇ఏᏊ⤌᥮࠼ᐇ㦂ࡀ୍⯡໬ࡋࡓࡇ࡜࠿ࡽ฼⏝⪅ࡣῶᑡࡋࡲࡋࡓࡀࠊ◊✲㐣⛬୍࡛ᐃᮇ㛫୍᫬ⓗ࡟ᚲせ࡟࡞ࡿࡶࡢࡢ◊✲ᐊ࡛‽ഛࡍࡿ࡟ࡣ㈇ᢸ࡜࡞ࡿࡼ࠺࡞ᶵჾࡸࠊ◊✲ᐊࡢ❧ࡕୖࡆ᫬࡟ᶵჾࡀᩚ࠺ࡲ࡛ࡢ
ᮇ㛫ࠊࡶࡋࡃࡣᨾ㞀ᶵჾࡢ⿵ಟ᏶஢ࡲ࡛࡟฼⏝࡛ࡁࡿྛ✀㑇ఏᏊゎᯒᶵჾࢆ඲Ꮫ࡟ᥦ
౪ࡋ࡚ࡁࡲࡋࡓࠋࡋ࠿ࡋࠊ඲యⓗ࡟タഛ➼ࡢ⪁ᮙ໬ࡀ㐍ࡳ㸪ࡉࡽ࡟ᖹᡂ  ᖺ  ᭶࡟ࡣ኱つᶍ࡞₃Ỉ஦ᨾࡀⓎ⏕ࡋ࡚࠾ࡾࠊࡑࡢᑐ⟇ࡢࡓࡵ࡟ࠊ௧࿴  ᖺᗘ࡟ࡣ඲㠃ⓗ࡞ᨵಟᕤ஦ࡀ⾜ࢃࢀ࡚࠸ࡲࡍࠋ ᖹᡂ  ᖺ  ᭶࡟㉳ࡁࡓᮾ᪥ᮏ኱㟈⅏࡟ࡼࡾࠊከࡃࡢ◊✲ᶵ㛵࡛⏕≀ᮦᩱ࣭㑇ఏ㈨※ࡀኻࢃࢀ◊✲ࡢ⥅⥆࡟ᨭ㞀ࢆࡁࡓࡋࡲࡋࡓࠋ෌ࡧࡇࡢࡼ࠺࡞ࡇ࡜ࡀ㉳ࡇࡿ࡜ᡃࡀᅜࡢ
ᅜ㝿ⓗ➇தຊ࡟ࡶᝏᙳ㡪ࢆ୚࠼࠿ࡡ࡞࠸࡜ࡢ༴᝹࠿ࡽࠊ᪥ᖖⓗ࡟◊✲⏝⏕≀㑇ఏ㈨※ࡢಖ⟶ࢆ⾜࠺ᩥ㒊⛉Ꮫ┬ࣉࣟࢪ࢙ࢡࢺࠕ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ
㸦,%%3㸧ࠖࡀឡ▱┴ᒸᓮᕷࡢᇶ♏⏕≀Ꮫ◊✲ᡤࢆ୰᰾ᣐⅬ࡜ࡋ࡚㛤ጞࡉࢀࠊᙜࢭࣥࢱ࣮
ࡣ໭ᾏ㐨ᆅ༊ࡢࢧࢸࣛ࢖ࢺᣐⅬ࡜ࡋ࡚ࡇࡢࣉࣟࢪ࢙ࢡࢺ࡟ཧ⏬ࡋ࡚࠸ࡲࡍࠋື ≀ᰁⰍయඹྠ฼⏝㒊㛛㛛 ື≀ᰁⰍయඹྠ฼⏝㒊㛛࡛ࡣࠊ⣽⬊ᇵ㣴タഛ࡜ࡋ࡚ࠊࢡ࣮ࣜࣥ࣋ࣥࢳࠊ&2 ࢖࣮ࣥ࢟ࣗ࣋ࢱ࣮ࠊ㐲ᚰᶵ࡞࡝ࢆࠊࡲࡓ⣽⬊ಖᏑタഛ࡜ࡋ࡚ࡣࠊᑓ⏝ࡢΥࢹ࢕࣮ࣉࣇ࣮ࣜࢨ
࣮࠾ࡼࡧ኱ᆺᾮయ❅⣲෾⤖ಖᏑᐜჾࢆഛ࠼࡚࠸ࡲࡍࠋᙜ㒊㛛࡛ࡣࠊ⣔⤫ศ㢮Ꮫࠊ㐍໬Ꮫⓗ࡟฼⏝౯್ࡀ㧗࠸࡜ᛮࢃࢀࡿึ௦ᇵ㣴⣽⬊㢮㸸့ங㢮㸦 ┠  ⛉  ✀  ள✀㸧ࠊ㫽㢮㸦 ┠  ⛉  ✀㸧ࠊ∐⹸㢮㸦 ┠⛉✀㸧࡜ࠊⓎ⏕Ꮫࡸ⏕໬Ꮫࠊ⣽⬊㑇ఏᏛ࡞࡝ࡢᐇ㦂࡟⏝࠸ࡽࢀࡿྛ✀ᇵ㣴⣽⬊ᰴࢆ෾⤖ಖᣢࡋ࡚࠾ࡾࠊᚲせ࡟ᛂࡌ࡚ෆእࡢ◊✲⪅࡬ࡢศ୚ࢆ⾜ࡗ࡚࠸ࡲࡍࠋࡇࢀࡽࡢ⣽⬊ࡢ࠺ࡕከࡃࡢࡶࡢࡣᪧ⌮Ꮫ㒊㝃ᒓື≀ᰁⰍయ◊✲᪋タ࡟࠾࠸࡚ᶞ❧ࠊ࠶ࡿ࠸ࡣ཰㞟ࡉࢀࡓࡶࡢ࡛࠶ࡾࠊྠ᪋タࡢ⤫ᗫྜᚋࡣࠊ୺࡟す⏣༓㭯Ꮚඛ⏕ࡢࡈດຊ࡟ࡼࡗ࡚⥔ᣢࡉࢀ࡚ࡁࡓࡶࡢ࡛ࡍࠋࡇࡢࡼ࠺࡞Ṕྐⓗ࡟㈗㔜࡞⣽⬊ࢆ௒ᚋࡶ౪୚ྍ⬟࡞≧ែ࡛⥔ᣢࡋ⥆ࡅࡿ࡜࡜ࡶ࡟ࠊᏛෆ࡛ࡢඛ➃ⓗ࡞◊✲࡟⏝࠸ࡽࢀࡓྛ✀ᇵ㣴⣽⬊㢮ࡸ⏕≀ヨᩱࢆᆅ㐨࡟཰㞟ࠊಖᏑࡋ࡚࠸ࡃࡇ࡜ࡶ௒ᚋࡢㄢ
㢟࡛ࡍࠋ᫖ᖺᗘ࠿ࡽ㛤ጞࡋࡓࢭࣥࢱ࣮ᨵ⤌஦ᴗ࡟࡜ࡶ࡞ࡗ࡚ࠊ ᭶ึ᪪࡟኱ᆺᾮయ❅⣲෾⤖ಖᏑᐜჾࢆ௬タࣉࣞࣁࣈ࡬࡜⛣㌿ࡋ࡚㐠⏝ࢆ㛤ጞࡋࡲࡋࡓࠋ⪁ᮙ໬ࡋࡓᾮయ❅⣲ࢱࣥࢡࡢ㐠ᦙࡣࠊ࠶ࡿព࿡ࠊ⥘Ώࡾⓗ࡞࡜ࡇࢁࡀ࠶ࡾࡲࡋࡓࡀࠊ᪋タ⫋ဨࡸᴗ⪅ࡢⓙࡉࡲࡢࡈᑾຊ࡛↓஦࡟ᘬ㉺ࢆ⤊࠼ࡽࢀࡓࡢࡣᖾ࠸࡛ࡋࡓࠋ௒ᖺᗘࠊ᪂タࡉࢀࡿ᪋タᘓ≀࡟ࡣ⥭ᛴ᫬࡟࠾ࡅࡿ⮬ᐙⓎ㟁ᶵ⬟ࢆഛ࠼ࡓࢹ࢕࣮ࣉࣇ࣮ࣜࢨ࣮ᐊࡀタ⨨ࡉࢀࡲࡍࠋᖹᖖ
᫬࡟࠾ࡅࡿヨᩱಖ⟶࡟㛵ࡍࡿࣂࢵࢡ࢔ࢵࣉሙᡤࡢᥦ౪ࡸࠊ㟁※႙ኻ᫬࡟࠾ࡅࡿヨᩱ㑊㞴ሙᡤࡢ☜ಖ࡞࡝ࢆ㏻ࡌ࡚ࠊ⏕≀Ꮫⓗヨᩱಖ඲ࡢሙࢆᥦ౪ࡋࡓ࠸࡜⪃࠼࡚࠸ࡲࡍࠋ௧ ࿴㸰㸰 ᖺ ᗘ 㑇ఏᏊᐇ㦂ඹྠ฼⏝㒊㛛࣭ື≀ᰁⰍయ◊✲㒊㛛 ಖ ᏲႠ⧋ࣜࢫࢺ
࣭ᐃᮇΎᤲ㸦ẖ᭶㸧
࣭௧࿴ 2 ᖺ 9 ᭶  ඲Ꮫ೵㟁࡟క࠺௬タືຊタഛᕤ஦− 28 −

ඹྠ฼⏝ᶵჾ㻌䞉㻌タഛ䝯䞊䜹䞊ྡ䞉ᆺ␒➼タഛ䛚䜘䜃ᶵჾྡ
ᇵ㣴ᐊ㻌䠄㻝㻜䟝䞉㻝㻠䟝䠅㻼㻝ᐇ㦂ᐊ㻼㻞ᐇ㦂ᐊ㻌䠄Ᏻ඲䜻䝱䝡䝛䝑䝖䠅పᐇ㦂ᐊ㻌䠄㻠䉝䠅

⣽⬊ಖᏑᐊᾮయ❅⣲ᘧ෾⤖ಖᏑᐜჾኴ㝧᪥㓟㻌䞉㻰㻾㻙㻝㻜㻜㻜㻾㻵㻌䞉⺯ග䝞䜲䜸䜲䝯䞊䝆䝱䞊㻲㼁㻶㻵㻌㻲㻵㻸㻹㻌䞉㻲㻸㻭㻙㻣㻜㻜㻜

໬ᏛⓎග᧜ᙳ⿦⨨㻭㼀㼀㻻㻌䞉㻱㼆㻙㻯㼍㼜㼠㼡㼞㼑䝀䝹᧜ᙳ⿦⨨

㻭㼀㼀㻻㻌䞉㻭㻱㻙㻢㻥㻟㻞䝀䝹᧜ᙳ⿦⨨

㻭㼀㼀㻻㻌䞉㻭㻱㻙㻢㻥㻞㻜㑇ఏᏊᑟධ⿦⨨㻌䠄䜶䝺䜽䝖䝻䝫䝺䞊䝍䞊䠅㻮㼕㼛㻙㻾㼍㼐㻌䞉㻳㼑㼚㼑㻌㻼㼡㼘㼟㼑㼞㑇ఏᏊᑟධ⿦⨨㻌䠄䜶䝺䜽䝖䝻䝫䝺䞊䝍䞊䠅㻿㻴㻵㻹㻭㻰㼆㼁㻌䞉㻳㼀㻱㑇ఏᏊᑟධ⿦⨨㻌䠄㑇ఏᏊ㖠䠅㻮㼕㼛㻙㻾㼍㼐㻌䞉㻴㼑㼘㼕㼛㼟㻌㻳㼑㼚㼑㻌㻳㼡㼚䝹䝭䝜䝯䞊䝍䞊

㻭㼀㼀㻻㻌䞉㻭㻮㻙㻞㻞㻜㻜᳜≀ᇵ㣴䝏䝱䞁䝞䞊㻌䠄䝁䜲䝖䝖䝻䞁䠅䠄㻟ྎ䠅㻷㻻㻵㼀㻻㻌䞉㻴㻺㻸㻙㻝㻜㻭䠄㻞ྎ䠅㻘㻌㻴㻺㻮㻙㻝㻜㻭䠄㻝ྎ䠅᳜≀䜲䞁䜻䝳䝧䞊䝍䞊䠄ேᕤẼ㇟ჾ䠅㼀㻻㻹㼅㻌䞉㻯㻸㻱㻙㻟㻜㻡኱ᆺᜏ᣺䛸䛖ᇵ㣴ᶵ㻌䠄䝞䜲䜸䝅䜵䞊䜹䞊䠅㼀㻭㻵㼀㻱㻯㻌䞉㻮㻾㻙㻟㻜㻜㻸㻲኱ᆺᜏ᣺䛸䛖ᇵ㣴ᶵ㻌䠄䝞䜲䜸䝅䜵䞊䜹䞊䠅㼀㻭㻵㼀㻱㻯㻌䞉㻮㻾㻙㻝㻤㻜㻸㻲ᑠᆺᜏ᣺䛸䛖ᇵ㣴ᶵ㻌䠄䝞䜲䜸䝅䜵䞊䜹䞊䠅㻌䠄㻞ྎ䠅㼀㻭㻵㼀㻱㻯㻌䞉㻮㻾㻙㻞㻟㻲㻼ᑠᆺ㉸㐲ᚰᶵ

㻮㼑㼏㼗㼙㼍㼚㻌䞉㼀㻸㻙㻝㻜㻜ᑠᆺ㉸㐲ᚰᶵ

㻴㼕㼠㼍㼏㼔㼕㻌䞉㻴㼕㼙㼍㼏㻌㻯㻿㻝㻜㻜㉸㐲ᚰᶵ㻌䠄㻞ྎ䠅㻴㼕㼠㼍㼏㼔㼕㻌䞉㻡㻡㻼㻙㻣㻞㧗㏿෭༷㐲ᚰᶵ㻌䠄㻞ྎ䠅㼀㻻㻹㼅㻌䞉㻾㻿㻙㻝㻤㻵㼂䠄㻝ྎ䠅㻘㻌㻿㼡㼜㼞㼑㼙㼍㻞㻝䠄㻝ྎ䠅ᚤ㔞㧗㏿෭༷㐲ᚰᶵ㻌䠄㻡ྎ䠅㼀㻻㻹㼅㻌䞉㻹㻾㻙㻝㻡㻜㻘㻌㻹㻾㼄㻙㻝㻡㻜㻘㻌㻹㼄㻙㻝㻜㻜㻘㻌㻹㼄㻙㻝㻜㻣㻘㻌㻹㼄㻙㻟㻜㻣䠄ྛ㻝ྎ䠅㻼㻯㻾⿦⨨㻭㻿㼀㻱㻯㻌䞉㻼㻯㻣㻜㻝㻼㻯㻾⿦⨨㻭㻿㼀㻱㻯㻌䞉㻼㻯㻣㻜㻤㻼㻯㻾⿦⨨㼀㼍㼗㼍㼞㼍㻌䞉㼀㼔㼑㼞㼙㼍㼘㻌㻯㼥㼏㼘㼑㼞㻌㻰㼕㼏㼑㻌㼀㼛㼡㼏㼔ᐃ㔞㻼㻯㻾⿦⨨㼀㼍㼗㼍㼞㼍㻌䞉㼀㼔㼑㼞㼙㼍㼘㻌㻯㼥㼏㼘㼑㼞㻌㻰㼕㼏㼑㻌㻾㼑㼍㼘㻌㼀㼕㼙㼑㻌㻿㼥㼟㼠㼑㼙㻌䊡䝟䝹䝇䝣䜱䞊䝹䝗㟁ẼὋື⿦⨨㻮㼕㼛㻙㻾㼍㼐㻌䞉㻼㼡㼘㼟㼣㼍㼢㼑㻣㻢㻜䝤䝻䝑䝔䜱䞁䜾⿦⨨㻌䠄Ὃືᘧ䞉䝉䝭䝗䝷䜲ᘧ䠅䠄㻞ྎ䠅㻭㼀㼀㻻㻌䞉㻭㻱㻙㻢㻢㻣㻜㼁㼂䜽䝻䝇䝸䞁䜹䞊㻲㼡㼚㼍㼗㼛㼟㼔㼕㻌䞉㻲㻿㻙㻤㻜㻜ศගගᗘィ㻿㻴㻵㻹㻭㻰㼆㼁㻌䞉㼁㼂㻙㻝㻢㻜ศගගᗘィ㻮㼑㼏㼗㼙㼍㼚㻌䞉㻰㼁㻙㻢㻡ᚤ㔞ศගගᗘィ㼀㼔㼑㼞㼙㼛㻌㻿㼏㼕㼑㼚㼠㼕㼒㼕㼏㻌䞉㻺㼍㼚㼛㻰㼞㼛㼜㻌㻞㻜㻜㻜䠄ỈᖹẼὶᆺ䠅㻌䜽䝸䞊䞁䝧䞁䝏㻌䠄㻞ྎ䠅㻿㻴㻻㼃㻭㻌䞉㻿㻙㻝㻟㻜㻜䠄ỈᖹẼὶᆺ䠅㻌䜽䝸䞊䞁䝧䞁䝏㻴㼕㼠㼍㼏㼔㼕㻌䞉㻼㻯㻴㻙㻝㻟㻜㻟㻮㻿ᐇయ㢧ᚤ㙾㻻㼘㼥㼙㼜㼡㼟㻌䞉㻿㼆㻢㻝㉸㡢Ἴ◚○⿦⨨㼀㻻㻹㼅㻌䞉㼁㻰㻙㻞㻜㻝኱ᆺ䜸䞊䝖䜽䝺䞊䝤㼀㻻㻹㼅㻌䞉㻲㻸㻿㻙㻝㻜㻜㻜୰ᆺ䜸䞊䝖䜽䝺䞊䝤㼀㻻㻹㼅㻌䞉㻸㻿㼄㻙㻡㻜㻜ᑠᆺ䜸䞊䝖䜽䝺䞊䝤㼀㻻㻹㼅㻌䞉㻮㻿㻙㻞㻠㻡ᑠᆺ䜸䞊䝖䜽䝺䞊䝤㻿㻭㻺㼅㻻㻌䞉㻹㻸㻿㻙㻞㻠㻜㻜஝⇕⁛⳦ᶵ㻌䠄㻟ྎ䠅㼅㼍㼙㼍㼠㼛㻌䞉㻿㻷㻢㻜㻝䠄㻞ྎ䠅㻘㻌㻿㻳㻙㻢㻞䠄㻝ྎ䠅㉸ప㻿㻭㻺㼅㻻䞉㻹㻰㻲㻙㻟㻥㻞㻌㻘㻿㻭㻺㼅㻻䞉㻹㻰㻲㻙㻠㻥㻟㻌㻘㻌㻼㻴㻯䞉㻹㻰㻲㻙㻟㻥㻠㻙㻼㻶䠄㻞ྎ䠅෭෾ᗜ㻌䠄㻙㻤㻜䉝䠅䠄㻠ྎ䠅䝗䝷䝣䝖䝏䝱䞁䝞䞊㻰㻭㻸㼀㻻㻺㻌䞉㻰㻲㻙㻯䠄≉䠅ᰯṇ⏝ศ㖡ෆⶶᆺ㟁Ꮚኳ⛗㻭㻒㻰㻌䞉㻲㼆㻙㻞㻜㻜㻜㼕䝉䝹䝋䞊䝍䞊

㻮㼍㼥㻌㼎㼕㼛㼟㼏㼕㼑㼚㼏㼑㻌㻶㻿㻭㻹− 29 −

௧࿴䠎ᖺᗘ䚷䝀䝜䝮䝎䜲䝘䝭䜽䝇◊✲䝉䞁䝍䞊䚷฼⏝⪅◊✲ㄢ㢟䠄㑇ఏᏊᐇ㦂ඹྠ฼⏝㒊㛛䞉ື≀ᰁⰍయඹྠ฼⏝㒊㛛䠅◊㻌㻌✲㻌㻌ㄢ㻌㻌㢟㻌㻌ྡᡤ㻌㻌ᒓ㒊㻌㻌㛛㻌㻌䞉㻌㻌ศ㻌㻌㔝㻌㻌➼

⫋㻌ྡ

Ặ㻌㻌ྡ

⌮Ꮫ◊✲㝔

໬Ꮫ䞉᭷ᶵ䞉⏕࿨໬Ꮫᩍ㻌ᤵᆏཱྀ㻌㻌࿴㟹⒴ᢚไ䝍䞁䝟䜽㉁p53䛚䜘䜃㛵㐃ᅉᏊ䛾ᵓ㐀ᶵ⬟┦㛵⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ

ᩍ㻌ᤵ

ỈἼ䚷ㄔ

㻌㻌䝣䝍䝩䝅䝁䜸䝻䜼䛾Ꮫ⩦䛚䜘䜃ᛶỴᐃ䛾◊✲⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ෸ᩍᤵ໭⏣㻌㻌୍༤ 㻌㻌᪂䛯䛺⑓ែ䝰䝕䝹ື≀䛾సฟ䛸ཎᅉ㑇ఏᏊ䛾ྠᐃ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ෸ᩍᤵ࿴ከ䚷࿴ᏹ 䚷㬆⚺㢮䜢⏝䛔䛯ⓎኌᏛ⩦䞉⏕ᡂ䛸䛭䛾⬻ෆศᏊᶵᵓ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫᩍ㻌ᤵ㯮ᒾ㻌㻌㯞㔛

XOᆺ䝖䝀䝛䝈䝭䛻䛚䛡䜛䝀䝜䝮ゎᯒ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ

෸ᩍᤵ

ᮌᮧ㻌㻌ᩔ

㻌㻌့ங㢮䛾⏕Ṫ䛻䛛䛛䜟䜛䝀䝜䝮ᶵ⬟䛻㛵䛩䜛◊✲⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫຓ㻌ᩍྜྷ⏣㻌㻌㑳ஓ

့ங㢮୙άᛶXᰁⰍయ䛾෌άᛶ໬ᶵᵓ䛾ゎᯒ⌮Ꮫ◊✲㝔⏕≀⛉Ꮫ䞉ከᵝᛶ⏕≀Ꮫᩍ㻌ᤵቑ⏣㻌㻌㝯୍ 㻌㻌့ங㢮䛚䜘䜃㫽㢮䛾ศᏊ㐍໬䛸㑇ఏⓗከᵝᛶ䛻㛵䛩䜛◊✲ඛ➃⏕࿨⛉Ꮫ ⏕࿨ᶵ⬟⛉Ꮫ◊✲䞉⏕≀᝟ሗゎᯒ⛉Ꮫ◊✲
◊✲㝔

ᩍ㻌ᤵ

ฟᮧ㻌㻌ㄔ

㻌᝟ሗ⛉Ꮫ◊✲㝔 ⏕࿨ே㛫᝟ሗ⛉Ꮫ䞉㻌䝞䜲䜸䜲䞁䝣䜷䝬䝔䜱䜽䝇ᩍ㻌ᤵ㐲⸨㻌㻌ಇᚨ 㻌㻌ศᏊ㐍໬ゎᯒ䛻䜘䜛䜰䝯䝸䜹䛾䝠䝵䜴䝍䞁䛾ఏ᧛⤒㊰䛾᥎ᐃ

⥲ྜ༤≀㤋

෸ᩍᤵ

Ụ⏣㻌㻌┿Ẏ 㻌㻌⌧⏕䛚䜘䜃㑇㊧ฟᅵ䛾ື≀㉁㈨ᩱ䛾ሷᇶ㓄ิ䛾Ỵᐃ◊✲㒊䞉㈨ᩱ㛤Ⓨ◊✲⣔௧࿴䠎ᖺᗘ䚷฼⏝≧ἣᡤ㻌㻌ᒓ㻌㻌

฼㻌⏝㻌⪅㻌ᩘ኱Ꮫ㝔⌮Ꮫ◊✲㝔㻤኱Ꮫ㝔ඛ➃⏕࿨⛉Ꮫ◊✲㝔㻝኱Ꮫ㝔᝟ሗ⛉Ꮫ◊✲㝔

㻝

⥲ྜ༤≀㤋

㻝

ྜ㻌㻌ィ㻌

㻝㻝

− 30 −

㻌㻌⺮ⓑ㉁䛾❧యᵓ㐀ゎᯒ䛻㛵䛩䜛◊✲Мဇ‫إ‬ԓᴾᴾ
኱Ꮫ㝔⌮Ꮫ◊✲㝔໬Ꮫ㒊㒊㛛 ᭷ᶵ࣭⏕࿨໬Ꮫศ㔝ᆏཱྀ ࿴㟹㸦ᶵჾ฼⏝㸧
˕ㄽᩥⓎ⾲
Nakagawa N., Sakaguchi S., Nomura T., Kamada R.,
Omichinski J. G., and Sakaguchi K. (2020)
The tetramerization domain of the tree shrew p53
protein displays unique thermostability despite sharing
high sequence identity with the human p53 protein.
Biochemical and Biophysical Research Communications
521: 681-686.
‫ۑ‬Ꮫ఍Ⓨ⾲㙊⏣⍠Ἠ㸪ᕤ⸨㢼ᶞ㸪㔜ಙ⚽἞㸪ᆏཱྀ࿴㟹: ዲ୰⌫ࢧࣈࢱ࢖ࣉከᵝ໬࡟࠾ࡅࡿ Ser/Thr ࣍ࢫࣇ࢓ࢱ࣮
ࢮ PPM1D ࡢᶵ⬟ゎ᫂.
➨ 93 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍, 2020 ᖺ 9 ᭶ 14 ᪥, web㛤ദphosphatase PPM1D on adipocyte differentiation andlipid droplet formation.
➨ 57 ᅇ࣌ࣉࢳࢻウㄽ఍, 2020 ᖺ 11 ᭶ 10 ᪥, web㛤ദ㙊⏣⍠Ἠ㸪ᕤ⸨㢼ᶞ㸪ᆏཱྀ࿴㟹: ዲ୰⌫ከᵝᛶ࡟࠾ࡅࡿ Ser/Thr ࣍ࢫࣇ࢓ࢱ࣮ࢮ PPM1D ࡢᶵ⬟ゎ᫂.㻌
➨ 43 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2020 ᖺ 12 ᭶ 3 ᪥,
web 㛤ദ
Rui Kamada, Fuki Kudoh, Shuji Shigenobu, andKazuyasu Sakaguchi: Ser/Thr phosphatase PPM1D
regulates neutrophil differentiation and heterogeneity.
➨ 14 ᅇࣉࣟࢸ࢖ࣥ࣍ࢫࣇ࢓ࢱ࣮ࢮᅜ㝿࢝ࣥࣇ࢓ࣞ
ࣥࢫ, 2020 ᖺ 12 ᭶ 10 ᪥, ⚄ᡞ኱Ꮫ་Ꮫ㒊ࢩࢫ࣓ࢵࢡࢫ࣮࣍ࣝ㸦⚄ᡞᕷ㸧/web 㛤ദItsumi Tani, Shogo Ito, Yui Oikawa, Rui Kamada, andKazuyasu Sakaguchi: Control of nucleolar formation
via phosphorylation of nucleolar protein nucleophosmin.
➨ 14 ᅇࣉࣟࢸ࢖ࣥ࣍ࢫࣇ࢓ࢱ࣮ࢮᅜ㝿࢝ࣥࣇ࢓ࣞ
ࣥࢫ, 2020 ᖺ 12 ᭶ 10 ᪥, ⚄ᡞ኱Ꮫ་Ꮫ㒊ࢩࢫ࣓ࢵࢡࢫ࣮࣍ࣝ㸦⚄ᡞᕷ㸧/web 㛤ദᆏཱྀ࿘ᘺ㸪୰ᕝኟ⨾㸪㙊⏣⍠Ἠ㸪James G. Omichinski㸪ᆏཱྀ࿴㟹: p53 ࣇ࢓࣑࣮ࣜᅄ㔞యᙧᡂࢻ࣓࢖ࣥࡢ⬨᳝ື≀ࡢ㐍໬࡟࠾ࡅࡿᏳᐃ໬ᶵᵓ.
➨ 93 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍, 2020 ᖺ 9 ᭶ 14 ᪥, web㛤ദ

Sae Uno, Toshiki Tsukamoto, Nozomi Kimura, Rui
Kamada, and Kazuyasu Sakaguchi: Functions of Ser/Thr
phosphatase PPM1D on Adipocyte Differentiation.
➨ 14 ᅇࣉࣟࢸ࢖ࣥ࣍ࢫࣇ࢓ࢱ࣮ࢮᅜ㝿࢝ࣥࣇ࢓ࣞ
ࣥࢫ, 2020 ᖺ 12 ᭶ 10 ᪥, ⚄ᡞ኱Ꮫ་Ꮫ㒊ࢩࢫ࣓ࢵࢡࢫ࣮࣍ࣝ㸦⚄ᡞᕷ㸧/web 㛤ദShuya Sakaguchi, Natsumi Nakagawa, Rui Kamada,James G. Omichinski, and Kazuyasu Sakaguchi:
Changes in structure and stability of p53 family
tetramerization domain in vertebrate evolution.
➨ 57 ᅇ࣌ࣉࢳࢻウㄽ఍, 2020 ᖺ 11 ᭶ 9 ᪥, web 㛤ദᆏཱྀ࿘ᘺ㸪୰ᕝኟ⨾㸪㙊⏣⍠Ἠ㸪James G. Omichinski㸪ᆏཱྀ࿴㟹: p53 ࣇ࢓࣑࣮ࣜࡢᅄ㔞యᵓ㐀࡜࣊ࢸࣟከ
㔞యࡢ⬨᳝ື≀࡟࠾ࡅࡿ㐍໬.㻌
໬Ꮫ⣔Ꮫ༠఍໭ᾏ㐨ᨭ㒊 2021 ᖺ෤Ꮨ◊✲Ⓨ⾲఍,
2021 ᖺ 1 ᭶ 26 ᪥, web 㛤ദYuna Nunokawa, Shuya Sakaguchi, Tatsuya Sakaguchi,
Rui Kamada, and Kazuyasu Sakaguchi: Effects ofoligomerization through coiled-coil on biologicalactivities.
➨ 57 ᅇ࣌ࣉࢳࢻウㄽ఍, 2020 ᖺ 11 ᭶ 9 ᪥, web 㛤ദᓮ㇂ឡᮍ㸪㙊⏣⍠Ἠ㸪ụෆ࿴ᛅ㸪㇂㔝ᆂᣢ㸪ᆏཱྀ࿴㟹: ⏕⣽⬊⺯ගࣉ࣮ࣟࣈ Triazapentalene ㄏᑟయࢆ⏝࠸ࡓ⏕⣽⬊ࡢ่⃭ᛂ⟅ゎᯒ.㻌
໬Ꮫ⣔Ꮫ༠఍໭ᾏ㐨ᨭ㒊 2021 ᖺ෤Ꮨ◊✲Ⓨ⾲఍,
2021 ᖺ 1 ᭶ 26 ᪥, web 㛤ദItsumi Tani, Yui Oikawa, Shogo Ito, Rui Kamada, andKazuyasu Sakaguchi: Control of nucleolar formation
via nucleolar protein nucleophosmin by PPM1D
phosphatase.
➨ 57 ᅇ࣌ࣉࢳࢻウㄽ఍, 2020 ᖺ 11 ᭶ 10 ᪥, web㛤ദJunya Imaizumi, Yuma Omata, Natsumi Nakagawa,Rui Kamada, and Kazuyasu Sakaguchi: Analysis ofmechanism for novel anti-antibiotic peptide r-Pep2
against Escherichia Coli.
➨ 57 ᅇ࣌ࣉࢳࢻウㄽ఍, 2020 ᖺ 11 ᭶ 10 ᪥, web㛤ദ
Sae Uno, Toshiki Tsukamoto, Nozomi Kimura, Rui
Kamada, and Kazuyasu Sakaguchi: Effects of Ser/Thr㒊㛛 ከᵝᛶ⏕≀Ꮫศศ㔝⏕≀⛉Ꮫ㒊ቑ⏣ 㝯୍୺࡞◊✲ᡂᯝࡣ௨ୗࡢ㏻ࡾ࡛࠶ࡿࠋ
(1) ྂ௦ DNA ศᯒࢆᑟධࡋࡓື≀ᆅ⌮Ꮫ࡟㛵ࡍࡿ◊✲ࢧࣁࣜࣥฟᅵࣄࢢ࣐㑇≀ࡢྂ௦ DNA ศᯒ࡟ࡼࡾࠊࢧࣁࣜࣥࣄࢢ࣐ࡢ࣑ࢺࢥࣥࢻࣜ࢔ DNA ⣔⤫ࡀclade 3a1 ࡛࠶ࡾࠊἢᾏᆅ᪉ࡢࣄࢢ࣐㞟ᅋ࡜ྠࡌ⣔⤫࡛࠶ࡿࡇ࡜ࡀุ᫂ࡋࡓ㸦Ⓨ⾲ㄽᩥ 1㸧ࠋ୍᪉ࠊ໭ᾏ㐨࡟ࡣ㏆⦕࡛ࡣ࠶ࡿࡀูࡢ clade 3a2 ࡀศᕸࡋࠊ
໭ᾏ㐨ࣄࢢ࣐ࡀ㛗ᮇ࡟ࢃࡓࡗ࡚ᆅ⌮ⓗ࡟㝸㞳ࡉࢀ࡚࠸ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ
ࡲࡓࠊ࢘ࣛࣝᒣ⬦࿘㎶࠿ࡽฟᅵࡋࡓ࢔ࢼࢢ࣐㑇≀ࡢྂ௦ DNA ศᯒ࡟ࡼࡾࠊ᭦᪂ୡᮎᮇ࠿ࡽ᏶᪂ୡ
࡟࠿ࡅ࡚ࠊ࣮ࣚࣟࢵࣃ࢔ࢼࢢ࣐ࡢศᕸᇦࡀ࢘ࣛࣝᮾ㒊࠿ࡽす᪉ࡢࣦ࢛ࣝ࢞Ἑᇦ࡬ᚋ㏥ࡍࡿ୍᪉ࠊ࢔
ࢪ࢔࢔ࢼࢢ࣐ࡢศᕸᇦࡀᮾ᪉࠿ࡽす᪉࡬㐍ฟࡋࡓࡇ࡜ࡀ♧ࡉࢀࡓ㸦Ⓨ⾲ㄽᩥ 2㸧ࠋྂ࠸༤≀㤋ᶆᮏࢆྵࡵࡓ⣔⤫ᆅ⌮Ꮫⓗゎᯒ࡟ࡼࡾࠊᮾ࣮ࣘࣛࢩ࢔࡟ศᕸࡍࡿࢩ࣋ࣜ࢔࢖ࢱࢳ࡟ࡣ
࣑ࢺࢥࣥࢻࣜ࢔ DNA ࡢ༡᪉⣔⤫࡜໭᪉⣔⤫ࡀᗈࡃศᕸࡋࠊᴟᮾᇦ࡛ࡣ㔜」ศᕸࡋ࡚࠸ࡿࡇ࡜ࡀ᫂
ࡽ࠿࡜࡞ࡗࡓ㸦Ⓨ⾲ㄽᩥ 3㸧ࠋࡉࡽ࡟ࠊ࢖࢖ࢬࢼ࡟
ࡘ࠸࡚ᮾ࣮ࣘࣛࢩ࢔㞟ᅋࡢศᏊ⣔⤫ࢆศᯒࡋࠊす࣮ࣘࣛࢩ࢔ࡢ᪤ሗࢹ࣮ࢱ࡜ẚ㍑ࡍࡿࡇ࡜࡟ࡼࡾࠊ
࣮ࣘࣛࢩ࢔඲ᇦࡢ⣔⤫ᆅ⌮ⓗ≉ᚩࢆᢕᥱࡍࡿࡇ࡜
ࡀ࡛ࡁࡓ㸦Ⓨ⾲ㄽᩥ 4㸧ࠋ᪥ᮏ࡟እ᮶✀࡜ࡋ࡚ศᕸᣑᩓࡋ࡚࠸ࡿࣁࢡࣅࢩࣥࡢヲ⣽࡞࣑ࢺࢥࣥࢻࣜ࢔ DNA ศᯒ࡟ࡼࡾࠊิᓥ
ෆ࡟࠾ࡅࡿศᕸᣑ኱ࡢ࣮ࣝࢺࢆ᥎ᐃࡍࡿࡇ࡜ࡀ࡛
ࡁࡓ㸦Ⓨ⾲ㄽᩥ 5㸧ࠋ(2) 㣗⫗㢮ࡢ୺せ⤌⧊㐺ྜ㑇ఏᏊ」ྜయ㸦MHC㸧ࡢศᏊ㐍໬Ꮫⓗ◊✲ච␿ࢩࢫࢸ࣒࡟࠾࠸࡚⑓ཎయ࡞࡝ࡢᢠཎࡢㄆ㆑
ࢆᢸ࠺ MHC 㑇ఏᏊ࡟ࡣ㧗࠸ከᵝᛶࡀぢࡽࢀࡿࡓࡵࠊࡑࡢࢹ࣮ࢱࡣ㔝⏕ື≀㞟ᅋࡢ㞟ᅋ㑇ఏⓗ≉ᚩࡸࡑࡢಖ඲⏕≀Ꮫ࡟࠾࠸࡚ࡶ㔜せ࡞᝟ሗࢆࡶࡓࡽ
ࡍࠋ᪥ᮏิᓥࢆྵࡴᮾ࢔ࢪ࢔࡟≉␗ⓗ࡟ศᕸࡍࡿ
ࢱࢾ࢟࡟࠾࠸࡚ࠊMHC class I DRB 㑇ఏᏊࡢᑐ❧㑇ఏᏊࢆ༢㞳ࡋࠊࡑࡢศᏊ㐍໬Ꮫⓗ≉ᚩࢆゎᯒࡋࡓࠋࡑࡢ⤖ᯝࠊศᕸࡢᗈᇦ࡟ࢃࡓࡗ࡚ศᕸࡍࡿᑐ❧㑇ఏᏊࠊ≉ᐃᆅᇦࡢࡳ࡟ศᕸࡍࡿᑐ❧㑇ఏᏊࡀᚓࡽ
ࢀࡓࠋࡇࢀࡽࡢᑐ❧㑇ఏᏊ࡟࠾ࡅࡿᢠཎ⤖ྜ㒊఩࡟ࡘ࠸࡚ࠊྠ⩏⨨᥮࡟ᑐࡍࡿ㠀ྠ⩏⨨᥮ࡢ๭ྜࢆ
ㄪ࡭ࡿ࡜ࠊ1 ࡼࡾ኱ࡁ࡞್ࢆ࡜ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜
࡞ࡾࠊṇࡢ㑅ᢥࢆཷࡅ࡚㐍໬ࡋࡓࡇ࡜ࡀ♧ࡉࢀࡓࠋࡑࡢ㑇ఏⓗከᵝᛶࡣࠊ㑇ఏᏊᗙ㛫⤌᥮࠼ࠊ⑓ཎయ
㥑ື࡟ࡼࡿṇࡢ㑅ᢥࠊᆅ⌮ⓗ㞀ቨ࡞࡝࡟ࡼࡗ࡚⥔ᣢࡉࢀ࡚ࡁࡓࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ୍᪉ࠊࢱࢾ࢟
MHC class II DRB ࡢᑐ❧㑇ఏᏊࡣ࢖ࢾ⛉࡟࠾࠸࡚༢⣔⤫࡛࠶ࡾࠊࢱࢾ࢟ࡢ✀ࡢศᒱࡀྂࡃ⊂⮬ࡢ㐍໬ࢆ⤒࡚ࡁࡓࡇ࡜ࡀ⪃࠼ࡽࢀࡓ㸦Ⓨ⾲ㄽᩥ 6㸧ࠋ᪥ᮏᅛ᭷✀࡛࠶ࡿࢽ࣍ࣥࢸࣥ࡟ࡘ࠸࡚ࠊMHC
class II DRB ࡢᑐ❧㑇ఏᏊࢆ༢㞳ࡋࠊࡑࡢศᏊ㐍໬Ꮫⓗ≉ᚩࢆゎᯒࡋࡓ࡜ࡇࢁࠊṇࡢ⮬↛㑅ᢥ࡜㑇ఏᏊᗙ㛫⤌᥮࠼࡟ࡼࡾ⥔ᣢࡉࢀ࡚ࡁࡓࡇ࡜ࡀ♧ࡉࢀࡓࠋᑐ❧㑇ఏᏊࡢศᏊ⣔⤫ࢆㄪ࡭ࡓ࡜ࡇࢁࠊ༢⣔⤫⩌ࡣᙧᡂࡉࢀࡎࠊ௚ࡢ࢖ࢱࢳ⛉ື≀✀ࡢᑐ❧㑇ఏᏊࢆྵࡴࢡࣛࢫࢱ࣮୰࡟ศᩓࡋ࡚࠾ࡾࠊ࢖ࢱࢳ⛉ ື ≀ ✀ 㛫 ࡛ ✀ ࢆ ㉸ ࠼ ࡓ ከ ᆺ 㸦 trans-species
polymorphism㸧ࡀ㉳ࡁ࡚࠸ࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋࡇ
ࢀࡣࠊ࢖ࢱࢳ⛉࡟࠾ࡅࡿᒓ࠾ࡼࡧ✀ࡢศ໬௨㝆ࡶࠊ

DRB ᑐ❧㑇ఏᏊࡢ✀ࠎࡢ⣔⤫ࡀᖹ⾮㑅ᢥ࡟ࡼࡾ⥔ᣢࡉࢀ࡚࠸ࡿࡇ࡜ࢆ♧ࡋ࡚࠸ࡿ㸦Ⓨ⾲ㄽᩥ 7㸧ࠋㄽᩥⓎⓎ⾲
1. Mizumachi, K., Spassov, N., Kostov, D., Raichev, E.G.,
Peeva, S., Hirata, D., Nishita, Y., Kaneko, Y., andMasuda, R. (2020) Mitochondrial haplogrouping of
the ancient brown bears (Ursus arctos) in Bulgaria,
revealed by the APLP method. Mammal Research
65: 413-421.
2. Kinoshita, E., Kosintsev, P.A., Abramov, A.V.,
Solovyev, V.A., Saveljev, A.P., Nishita, Y., andMasuda, R. (2020) Holocene changes in the
distributions of Asian and European badgers(Carnivora: Mustelidae: Meles) inferred fromancient DNA analysis. Biological Journal of theLinnean Society 129: 594-602.
3. Ishikawa, K., Abramov, A.V., Amaike, Y., Nishita,Y., and Masuda, R. (2020) Phylogeography of theSiberian weasel (Mustela sibirica), based on a
mitochondrial DNA analysis. Biological Journal of
the Linnean Society 129: 587-593.
4. Sato, T., Abramov, A.V., Raichev, E.G., Kosintsev,
P.A., Väinölä, R., Murakami, T., Kaneko, Y., andMasuda, R. (2020) Phylogeography and population
history of the least weasel (Mustela nivalis) in the
Palearctic based on multilocus analysis. Journal of
Zoological Systematics and Evolutionary Research
58: 408-426.
5. Endo, Y., Lin, L.K., Yamazaki, K., Pei, K.J.C.,
Chang, S.W., Chen, Y.J., Ochiai, K., Yachimori, S.,
Anezaki, T., Kaneko, Y., and Masuda, R. (2020)
Introduction and expansion history of the masked
palm civet, Paguma larvata, in Japan, revealed by
mitochondrial DNA control region and cytochromeb analysis. Mammal Study 45: 243-251.
6. Bartocillo, A.M., Nishita, Y., Abramov, A.V., andMasuda, R. (2020) Molecular evolution of MHC class
II DRB exon 2 in Japanese and Russian raccoon dogs,
Nyctereutes procyonoides (Carnivora: Canidae).
Biological Journal of the Linnean Society 129:
61-73.
7. Hosotani, S., Nishita, Y., and Masuda, R. (2020)
Genetic diversity and evolution of the MHC class II
DRB gene in the Japanese marten, Martes melampus(Carnivora: Mustelidae). Mammal Research 65:
573-582.
8. ቑ⏣㝯୍ (2020) ့ங㢮Ꮫࡢ᭱๓⥺࡛ά㌍ࡍࡿ
࡟ࡣ࡝࠺ࡋࡓࡽࡼ࠸࠿㸬့ங㢮⛉Ꮫ 60: 377-384㸬
Ꮫ఍Ⓨ⾲
1. ቑ⏣㝯୍㸸“ࡦࡄࡲᏛ࡬ࡢᣍᚅ”㸬➨29ᅇඛ➃⛉Ꮫ⛣ື኱Ꮫ㸦㐨Ẹ࢝ࣞࢵࢪ㐃ᦠㅮᗙ㸧㸪2020ᖺ11᭶14᪥㸪᪫ᕝᕷ኱㞷ࢡࣜࢫࢱ࣮ࣝ࣍ࣝᅜ㝿఍㆟ሙ኱఍㆟ᐊ㸦໭ᾏ㐨᪫ᕝᕷ㸧㸬− 32 −

2. Ryuichi Masuda: Our joint studies between Japanand Russia since 1997: Zoogeography andpopulation genetics of mammals between theEurasian Continent and Japanese Islands, In“Online Seminar on JSPS International Programsfor Russian Scholars and PhD Students ” by
Moscow State University-Hokkaido University
Joint Office in Moscow, November 30, 2020.
3. 㐲⸨ඃ㸪㛗⏣┤ᶞ㸪㛫㔝ຮ㸪ቑ⏣㝯୍㸸඲ࢤࣀ࣒ゎᯒ࡟ࡼࡿ໭ᾏ㐨ࡢࣄࢢ࣐ࡢ㞟ᅋᙧᡂྐࡢ
ゎ᫂㸬᪥ᮏື≀Ꮫ఍➨91ᅇ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧㸪2020ᖺ9᭶4᪥㸬
4. ᮡᒣඃ㔛㸪す⏣⩏᠇㸪Jouni Aspi㸪Gerhardus
Lansink㸪ቑ⏣㝯୍㸸ࢡࢬࣜ(Gulo gulo)ࡢࣇ࢕ࣥ
ࣛࣥࢻ㞟ᅋ࡟࠾ࡅࡿMHC class Ⅱ DRB㑇ఏᏊࡢከᵝᛶ㸬᪥ᮏື≀Ꮫ఍໭ᾏ㐨ᨭ㒊➨65ᅇ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧㸪2021ᖺ3᭶20᪥㸬
5. 㕥ᮌ࿴㸪す⏣⩏᠇㸪ኳụᗤ௓㸪Alexei Abramov㸪ቑ⏣㝯୍㸸࣑ࢺࢥࣥࢻࣜ࢔DNAศᯒ࡟ࡼࡿ࢔
ࣝࢱ࢖࢖ࢱࢳ(Mustela altaica)ࡢ⣔⤫ᆅ⌮㸬᪥ᮏື≀Ꮫ఍໭ᾏ㐨ᨭ㒊➨65ᅇ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧㸪2021ᖺ3᭶20᪥㸬
6. 㐲⸨ඃ㸪㛗⏣┤ᶞ㸪㛫㔝ຮ㸪ቑ⏣㝯୍㸸㞤㞝ࡢ⛣ື⬟ຊᕪ࡟ࡼࡿࣄࢢ࣐ࡢ㞟ᅋᙧᡂྐ㸬᪥ᮏື≀Ꮫ఍໭ᾏ㐨ᨭ㒊➨65ᅇ኱఍㸦࢜ࣥࣛ࢖ࣥ㸧㸪2021ᖺ3᭶20᪥㸬኱Ꮫ㝔ඛඛ➃⏕࿨⛉Ꮫ◊✲㝔⏕࿨ᶵ⬟⛉Ꮫ◊✲㒊㛛⏕≀᝟ሗゎᯒ⛉Ꮫ◊✲ศ㔝ฟᮧ ㄔ㸦ᶵჾ฼⏝㸧࠙Ꮫ⾡ㄽᩥࠚ
Penkhrue, W., Jendrossek, D., Khanongnuch, C.,
Pathom-Aree, W., Aizawa, T., Behrens, R.L., Lumyong S.
(2020) Response surface method for polyhydroxybutyrate(PHB) bioplastic accumulation in Bacillus drentensis
BP17 using pineapple peel. PLOS ONE 15(3): e0230443
Yasuda, S., Akiyama, T., Nemoto, S., Hayashi, T., Ueta,
T., Kojima, K., Tsukamoto, T., Nagatoishi, S., Tsumoto,K., Sudo, Y., Kinoshita, M., Murata, T. (2020)
Methodology for Further Thermostabilization of an
Intrinsically Thermostable Membrane Protein Using
Amino Acid Mutations with Its Original Function
Being Retained. Journal of Chemical Information andModeling 60(3): 1709-1716

Ishimori, K., Kinjo, M., Komatsuzaki, T., Maenaka, K.,
Yao, M. (2020) Biophysical Research in Hokkaido
University, Japan. Biophysical Reviews 12(2): 233-236
Yamamoto, A., Tsukamoto, T., Suzuki, K., Hashimoto,E., Kobashigawa, Y., Shibasaki, K., Uchida, T., Inagaki,F., Demura, M., Ishimori, K. (2020) Spectroscopic
Characterization of Halorhodopsin Reconstituted into
Nanodisks Using Native Lipids. Biophysical Journal118(11): 2853-2865
Shibata, Y., Kurokawa, T., Aizawa, T., Gong, JP.
(2020) Bactericidal effect of cationic hydrogels
prepared from hydrophilic polymers. Journal ofApplied Polymer Science 137(48): e49583
Haque, S., Kikukawa, T., Tamaoki, N. (2020)
Photoisomerization of azobenzene units drives thephotochemical reaction cycles of proteorhodopsin andbacteriorhodopsin analogues. Organic & Biomolecular
Chemistry 18(32): 6312-6327
Komatsu, Y., Wada, Y., Izumi, H., Shimizu, T., Takeda,
Y., Aizawa, T. (2020) 1H NMR metabolomic andtranscriptomic analyses reveal urinary metabolites asbiomarker candidates in response to protein
undernutrition in adult rats. British Journal of Nutrition
125(6): 633-643
Murabe, K., Tsukamoto, T., Aizawa, T., Demura, M.,
Kikukawa, T. (2020) Direct Detection of the Substrate
Uptake and Release Reactions of the Light-Driven
Sodium-Pump Rhodopsin. Journal of the American
Chemical Society 142(37): 16023-16030
Matsuo, J., Kikukawa, T., Fujisawa, T., Hoff, D. W.,
Unno, M. (2020) “Watching” a Molecular Twist in a
Protein by Raman Optical Activity. The Journal of
Physical Chemistry Letters 11(20): 8579–8584
Kojima, K., Yoshizawa, S., Hasegawa, M., Nakama,M., Kurihara, M., Kikukawa, T., Sudo, Y. (2020)
Lokiarchaeota archaeon schizorhodopsin-2 (LaSzR2)
is an inward proton pump displaying a characteristicfeature of acid-induced spectral blue-shift Scientific
Reports 10(1): 20857
Kusama, K, Miyagawa, M, Ota, K, Kuwabara, N,
Saeki, K, Ohnishi, Y, Kumaki, Y, Aizawa, T, Nakasone,
T, Okamatsu, S, Miyaoka, H, Tamura, K. (2020)
Cordyceps militaris Fruit Body Extract Decreases
Testosterone Catabolism and Testosterone-Stimulated
Prostate Hypertrophy. Nutrients 13(1): e50

Komatsu, Y., Shimizu, Y., Yamano, M., Kikuchi, M.,
Nakamura, K., Ayabe, T., Aizawa, T. (2020) Disease
Progression-Associated Alterations in Fecal Metabolites
in SAMP1/YitFc Mice, a Crohn's Disease Model.
Metabolomics 16(4): 48

Nakamizo, Y., Fujisawa, T., Kikukawa, T., Okamura,A., Baba, H., Unno, M. (2021) Low-temperature
Raman spectroscopy of sodium-pump rhodopsin from
Indibacter alkaliphilus: Insight of Na+ binding foractive Na+ transport Physical Chemistry Chemical
Physics 23: 2072-2079

Aizawa, T., Demura, M., Gohara, K., Haga, H.,

Yokoyama, Y., Yano, S., Kurita, R., Karasawa, M.,− 33 −

Tanaka, H., Takahashi, H., Kikukawa, T., Sonoyama,M., Takenaka, K. (2021) Effects of salt and gel
network structures on purple membrane stacking inhydrogels immobilized with poly(vinyl alcohol).
Journal of Applied Physics 129: 014701
࠙Ꮫ఍Ⓨ⾲ࠚ
Yi Wang, Rina Hiramine, Chisato Toyokawa,
Tomoyasu Aizawa: Bactericidal Mechanisms Of An
α-Defensin, Cryptdin-4: Effect Of Peptide Redox And
Culture Condition Of E. coli. ➨ 20 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍, 2020 ᖺ 7 ᭶ 28 ᪥, ࢜ࣥࣛ࢖ࣥ.
Hao Gu, Koki Onuma, Hiroaki Ishida, Yasuhiro
Kumaki, Takashi Tsukamoto, Takashi Kikukawa),
Makoto Demura, Hans J. Vogel, Tomoyasu Aizawa:
Development of Expression of Recombinant Small
Peptides Through Calmodulin-fusion Protein System.
➨ 20 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍, 2020 ᖺ 7 ᭶ 28 ᪥,࢜ࣥࣛ࢖ࣥ.
Tomona Iizuka, Hélène Sénéchal, Pascal Poncet,
Tomoyasu Aizawa: Gene Identification Of An Allergen
Peptide From Cypress Pollen Using Next Generation
Sequencer And Its Over Expression For Analysis. ➨20 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍, 2020 ᖺ 7 ᭶ 28 ᪥, ࢜ࣥࣛ࢖ࣥ.
Yuchi Song, Tomoyasu Aizawa: Enhancement Of The
Expression Level Of Recombinant α-defensin Derived
From Mouse By Inclusion Body Formation In The E.
coli Cytoplasm. ➨ 20 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍,2020 ᖺ 7 ᭶ 28 ᪥, ࢜ࣥࣛ࢖ࣥ.
㇂ᪿ, ኱἟ᖾᬦ, ຍ⸨㈗⣧, ▼⏣༤᫛, ⇃ᮌᗣ⿱,ሯᮏ༟, ⳥ᕝᓠᚿ, ฟᮧㄔ, Vogel Hans J., ┦ἑᬛᗣ : Expression and Purification of Intact Small
Peptides through a Novel Calmodulin-Fusion Protein
System. ➨ 58 ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍, 2020 ᖺ 9
᭶ 16 ᪥, ࢜ࣥࣛ࢖ࣥ.
⋤୍ , ⪰೧㖭, ᖹᓠ㔛⳯, ㇏ᕝ༓᛭, ┦ἑᬛᗣ:
Antibacterial mechanism of an Ș-defensin, cryptdin-4
in redox status under aerobic and anerobic conditions.
➨ 58 ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍, 2020 ᖺ 9 ᭶ 16 ᪥,࢜ࣥࣛ࢖ࣥ.
Ᏽ㞵㐜, ⪰೧㖭, 䰛ᑡ⏨, ᳿ᩥ඾, ⋤୍, ┦ἑᬛᗣ:A method for producing recombinant cryptdin byenhancing inclusion body formation. ➨ 58 ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍, 2020 ᖺ 9 ᭶ 16 ᪥, ࢜ࣥࣛ࢖ࣥ.
㒯 㟹 ᗣ , 㣤 ሯ ཭ ⳯ , 㝣 ᑠ ཮ , ┦ ἑ ᬛ ᗣ : NMR
Studies on Cup s 7, an Novel Allergen from Cypress
Pollen. ➨ 58 ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍, 2020 ᖺ 9 ᭶
16 ᪥, ࢜ࣥࣛ࢖ࣥ.
⳥ᕝᓠᚿ: Photoreaction analysis of microbial rhodopsin

by flash photolysis techniques. ➨ 58 ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍, 2020 ᖺ 9 ᭶ 17 ᪥, ࢜ࣥࣛ࢖ࣥ.
┦ ἑ ᬛ ᗣ : Development and application of novel
overexpression systems of antimicrobial peptides. ➨58 ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍, 2020 ᖺ 9 ᭶ 18 ᪥, ࢜ࣥࣛ࢖ࣥ.
㇂ᪿ㸪ຍ⸨㈗⣧㸪▼⏣༤᫛㸪⇃ᮌᗣ⿱㸪ሯᮏ༟㸪⳥ᕝᓠᚿ㸪ฟᮧㄔ㸪Vogel Hans J. ┦ἑᬛᗣ: ࢝ࣝࣔࢪࣗࣜࣥ⼥ྜࢱࣥࣃࢡ㉁ࢩࢫࢸ࣒ࢆ౑⏝ࡋࡓᏳᐃྠ఩యᶆ㆑ࢭࢡࣟࣆࣥ P1 ࡢ኱㔞Ⓨ⌧࡜ NMR
ᵓ㐀ゎᯒ. ➨ 59 ᅇ NMR ウㄽ఍, 2020 ᖺ 11 ᭶ 19 ᪥,
G ࣓ࢵࢭ⩌㤿㸦㧗ᓮᕷ㸧.

኱Ꮫ㝔᝟
᝟ሗ⛉Ꮫ◊
◊✲㝔
㝔
⏕࿨ே㛫᝟ሗ⛉Ꮫ㒊㛛ࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫศ㔝㐲⸨ ಇᚨ
᱂ᇵ✀࣭ྂ௦ࣄࣙ࢘ࢱࣥࡢศᏊ⣔⤫ゎᯒ㉳※࡜ఏ᧛⤒㊰ゎ᫂ࡢศᏊ⣔⤫ゎᯒࡢࡓࡵࠊ࢔
ࢪ࢔ࠊ࣮ࣚࣟࢵࣃࠊ࢔ࣇࣜ࢝ࠊ࢔࣓ࣜ࢝ࡢ᱂ᇵ✀࡜ 㔝 ⏕ ✀ 㸦 Lagenaria abyssinica, L. sphaerica, L.
breviflora㸧ࡢྜィ 48 ᶆᮏ࡟ࡘ࠸࡚ࠊRAD-seq ࡟ࡼࡗ࡚㓄ิྲྀᚓ࣭ゎᯒࡋ SNP ࢆᚓࡓࠋከࡃࡢᶆᮏࡣ
ᆅᇦᅛ᭷ࡢ⣧⣔࡟㏆࠸ࡶࡢ࡜ᮇᚅࡉࢀ࡚࠾ࡾࠊ
SNP ࡢゎᯒ⤖ᯝ࠿ࡽࡶ୍㒊ࢆ㝖࠸࡚㧗࠸㏆஺ಀᩘࡀ☜ㄆ࡛ࡁࡓࠋ๓ᖺࡲ࡛ࡢゎᯒ࠿ࡽࠊ࢔ࣇࣜ࢝ࢆ
㉳※ᆅ࡜ࡋ࡚࢔ࢪ࢔࡟ఏࢃࡗࡓࣄࣙ࢘ࢱࣥࡀ᪥ᮏ
௜㏆ࢆ⤒⏤ࡋ࡚࢔࣓ࣜ࢝኱㝣࡬Ώࡗࡓ࡜࠸࠺༢୍
ࣔࢹࣝࢆ⪃࠼࡚࠸ࡓࡀࠊSNP ࡢ୺ᡂศศᯒࡢ⤖ᯝࡣࠊࡼࡾ」㞧࡞ఏ᧛⤒㊰ࢆᬯ♧ࡋ࡚࠸ࡓࠋࡑࡇ࡛ࠊ
RAD-seq ࡢࢹ࣮ࢱ࡛ࡣ༑ศ࡞ゎീᗘࡀᚓࡽࢀ࡞࠸
࡜ุ᩿ࡋࠊ᪥ᮏࡢᅾ᮶✀ࢆ㏣ຍࡋ࡚඲ࢤࣀ࣒ゎᯒࢆ⾜࠺ࡇ࡜࡜ࡋࡓࠋ᪥ᮏࡢᅾ᮶✀࡟ࡘ࠸࡚ࡣࠊ㎰ᴗ⏕≀㈨※ࢪ࣮ࣥࣂࣥࢡ࠿ࡽࣄࣙ࢘ࢱࣥ࠾ࡼࡧࣘ
࢘࢞࢜ࡢᅾ᮶✀࠾ࡼࡧ⫱ᡂ✀ࡢ✀Ꮚࢆධᡭࡋࠊ
RAD-seq ࡟⏝࠸ࡓ✀࡜ేࡏ 60 ࢧࣥࣉࣝ࡟ࡘ࠸࡚
DNA ᢳฟ࡜ NGS ゎᯒࢆ⾜ࡗ࡚࠸ࡿࠋ
ྂ௦ࣄࣙ࢘ࢱࣥ࡟ࡘ࠸࡚ࡣࠊ⁠㈡┴ࡢ⢖ὠ†ᗏ㑇㊧࠿ࡽⓎぢࡉࢀࡓ⣙ 1 ୓ 1 ༓ᖺ๓ࡢࡶࡢ࡜᥎ᐃ
ࡉࢀࡿ✀Ꮚᶆᮏࠊឡ፾┴ࡢ᪂㇂ྂ᪂㇂㑇㊧࣭᪂㇂᳃ࣀ๓㑇㊧㸦ឡ፾┴௒἞ᕷ㸧࠿ࡽⓎぢࡉࢀࡓᘺ⏕㹼ྂቡ᫬௦㡭࡜᥎ᐃࡉࢀࡿᯝ⓶ᶆᮏࢆධᡭࡋࠊࡇ
ࢀࡽࡢ඲㛗ࢤࣀ࣒ DNA Ỵᐃࢆ⾜࠺ࡇ࡜ࢆ┠ⓗ࡟DNA ᢳฟࢆ㐍ࡵࡓࠋྂ௦㑇㊧ࡣỈᾐ(⢖ὠ†ᗏ)࠾
ࡼࡧ஝⇱(᪂㇂)ࡢ≧ែ࡛ṧ␃ DNA ࡜࠸࠺ほⅬ࠿ࡽࡣಖᏑ≧ែࡀᝏࡃࠊ㏻ᖖࡢᡭἲ࡟ࡼࡿ DNA ᢳฟࡣᴟࡵ࡚㞴ࡋ࠿ࡗࡓࡀࠊ᪂ࡋࡃᨵⰋࡋࡓ᪉ἲ࡟ࡼࡾ
ẚ㍑ⓗ㧗཰㔞࡛ DNA ࢆᚓࡿࡇ࡜ࡀ࡛ࡁࡓࠋDNA− 34 −

ရ㉁ࢳ࢙ࢵࢡࡢ⤖ᯝࠊ๓⪅ࡢ DNA ࡣศゎࡀ㐍ࢇ࡛࠸ࡓࡀࠊᚋ⪅ࡣ㧗ရ㉁ࡢ DNA ࡀ☜ㄆࡉࢀࡓࠋࡇࢀ
ࡽ࡟ࡘ࠸࡚ࠊNGS ゎᯒࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊ᭱኱࡛඲㛗ࡢ 5㸣⛬ᗘ࡟┦ᙜࡍࡿ᩿∦ࢆᚓࡿࡇ࡜ࡀ࡛
ࡁࡓࠋ࣐ࢵࣆࣥࢢࡢ⤖ᯝࠊゎㄞࡉࢀࡓ㓄ิࡣ 11 ᮏ࠶ࡿᰁⰍయࡢ࠺ࡕ 8 ␒ᰁⰍయ࡟㞟୰ࡋ࡚࠾ࡾࠊ௚
ࡢᰁⰍయ࡟࣐ࢵࣆࣥࢢࡉࢀࡓࡶࡢࡣᑡ࡞࠿ࡗࡓࠋ
࣐ࢵࣆࣥࢢ୙ྍ⬟࡞㓄ิࡢ኱༙ࡣࣇ࢓࣮ࢪ⏤᮶ࡢ㓄ิ࡟୍⮴ࡋ࡚࠾ࡾࠊࣂࢡࢸࣜ࢔࡟ࡼࡿ⭉㣗࡜ࡑࢀ࡟⥆ࡃࣇ࢓࣮ࢪឤᰁ࡟ࡼࡗ࡚ DNA ࡢከࡃࡀኻ
ࢃࢀࡓ࡜⪃࠼ࡽࢀࡿࠋྂ௦ DNA ࡣ᪂ࡓ࡟ࢤࣀ࣒ゎㄞࡋࡓᅾ᮶✀࡜ేࡏ࡚ḟᖺᗘ࡟ゎᯒࢆ⾜࠺ணᐃ࡛࠶ࡿࠋⓎ⾲ㄽᩥ 
Hiro Takahashi, Noriya Hayashi, Yuta Hiragori, Shun
Sasaki, Taichiro Motomura, Yui Yamashita, Satoshi
Naito, Anna Takahashi, Kazuyuki Fuse, Kenji Satou,
Toshinori Endo, Shoko Kojima, Hitoshi Onouchi.
(2020) Comprehensive genome-wide identification ofangiosperm upstream ORFs with peptide sequences
conserved in various taxonomic ranges using a novel
pipeline, ESUCA. BMC Genomics 21, 260

Archaeological Science: Reports 34: 102635.
https://doi.org/10.1016/j.jasrep.2020.102635
Eda, M., Yamasaki, T., Izumi, H., Tomita, N., Konno,
S., Konno, M., Murakami, H., and Sato, F. (2020)
Cryptic species in a vulnerable seabird: short-tailed
albatross consists of two species. Endangered Species
Research 43: 375-386. https://doi.org/10.3354/esr01078.
ኴ⏣ ᬗ࣭᭹㒊 ⸅࣭እᒣ㞝኱࣭∵ᓥኟᮍ࣭Ụ⏣┿Ẏ࣭Ἠ ὒỤ࣭኱Ὀྖ⣖அ (2020)ࠕ᰿ᐊᕷ㛗⠇࡟⁻╔ࡋࡓࣛࢵࢥ㦵᱁ࡢグ㘓ࠖ᰿ᐊᕷṔྐ࡜⮬↛ࡢ㈨ᩱ㤋⣖せ 32: 43-48ࠋ

௨ୗࡢ」ᩘ㒊㛛฼⏝ࢢ࣮ࣝࣉࡢሗ࿌ࡣࠊᐇ㦂⏕≀ඹྠ฼⏝㒊㛛ࢆཧ↷ࠋ኱Ꮫ㝔⌮Ꮫ◊✲㝔

Hiro Takahashi, Shido Miyaki, Hitoshi Onouchi,
Taichiro Motomura, Nobuo Idesako, Anna Takahashi,
Masataka Murase, Shuichi Fukuyoshi, Toshinori Endo,
Kenji Satou, Satoshi Naito & Motoyuki Itoh (2020)
Exhaustive identification of conserved upstream open
reading frames with potential translational regulatory
functions from animal genomes. Scientific Reports
10, 16289◊✲Ⓨ⾲ Ώ㒊 ኱, ‫‮‬ὸ ᾈྐ, 㛗⏣ ┤ᶞ, 㔛ᮧ ࿴ᾈ, 㐲⸨ಇᚨRAD seq ࢹ࣮ࢱ࡟ᇶ࡙࠸ࡓࣄࣙ࢘ࢱࣥࡢศᏊ⣔⤫ࡢᆅ⌮ⓗศᕸ
➨ 74 ᅇ᪥ᮏே㢮Ꮫ఍኱఍㸪2020 ᖺ 10 ᭶ 31 ᪥, ࢜ࣥࣛ࢖ࣥ㸦ᒣ᲍኱㸧.

⥲ྜ༤≀㤋
◊✲㒊
 ㈨ᩱ㛤Ⓨ◊✲⣔Ụ⏣ ┿Ẏ㸦㸦ᶵჾ฼⏝㸧

ࠚ࠙ㄽᩥࠚ
Eda, M. (in press) The osteological microevolution of
red junglefowl and domestic fowl under thedomestication process. Quaternary International.
https://doi.org/10.1016/j.quaint.2020.10.001
Eda, M., Morimoto, M., Mizuta, M. and Inoué, T.
(2020) ZooMS for birds: discrimination of Japanesearchaeological chickens and indigenous pheasantsusing collagen peptide fingerprinting. Journal of− 35 −⏕≀⛉Ꮫ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศ㔝ỈἼ ㄔ
⏕≀⛉Ꮫ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศ㔝໭⏣ ୍༤
⏕≀⛉Ꮫ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศ㔝࿴ከ ࿴ᏹ
⏕≀⛉Ꮫ㒊㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫศศ㔝㯮ᒾ 㯞㔛
㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫศศ㔝⏕≀⛉Ꮫ㒊ᮌᮧ ᩔ

㈨ ᩱ࣭ࢭࣥࢱ࣮ ฼⏝ᡭ⥆ࡁࣇ࣮ࣟࢳ࣮ࣕࢺ㸦ᖹᡂ 23 ᖺᗘ௨㝆㸧࣭໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛 ᪋タ฼⏝ࡢᡭᘬࡁ㸦ู⾲ 1 ඹྠ฼⏝ᶵჾࣜࢫࢺ ᖹᡂ 25 ᖺ 4 ᭶௨㝆㸧㸦ู⾲ 2 ᐇ㦂⏝ື≀౪⤥⣽๎㸧࣭໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮つ⛬࣭໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㐠Ⴀጤဨ఍ෆつ࣭໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㛗㑅⪃ෆつ− 37 −

ࢭࣥࢱ࣮฼⏝ᡭ⥆ࡁࣇ࣮ࣟࢳ࣮ࣕࢺձ ஦๓࡟฼⏝ྍ⬟ᶵჾࡸࢫ࣮࣌ࢫࡢ✵ࡁ≧ἣࢆ☜ㄆࡋ࡚ୗࡉ࠸ࠋ
ࢭࣥࢱ࣮࢙࢘ࣈࢧ࢖ࢺ    https://www.sci.hokudai.ac.jp/gdynamics/ၥ࠸ྜࢃࡏඛ㸦ࢭࣥࢱ࣮஦ົ㸧e-mail : cepa@sci.hokudai.ac.jp (ෆ⥺ 3580)

Ўղ ฼⏝⏦ㄳ᭩࣭฼⏝⪅ྡ⡙ࢆࢭࣥࢱ࣮࢙࢘ࣈࢧ࢖ࢺࡼࡾࢲ࣮࢘ࣥࣟࢻࡍࡿࠋ
㸦඲㒊㛛ඹ㏻ࣇ࢛࣮࣐ࢵࢺ࡛ࡍࠋ㸧ὀ㸧ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛㸦ᮾᲷ㸧฼⏝⪅ࡢ࠺ࡕ᪂つࡢ᪉࡜ࠊ⥅⥆฼⏝࡛࠶ࡿࡀ⏦ㄳෆᐜ࡟ኚ᭦ࡢ࠶ࡿ᪉ࡣࠊୖグࡢ௚ࠕᮾᲷ฼⏝⏦ㄳ᭩ࠖࡢᥦฟࡀᚲせ࡛ࡍࠋЎճ ྛᵝᘧ࡟ᚲせ஦㡯ࢆグධࡍࡿࠋЎմ グධ῭ࡳࡢྛᵝᘧࢆ⤒㈝ࡢᨭᡶ㈐௵⪅ࡢ e-mail ࢔ࢻࣞࢫ࠿ࡽࢭࣥࢱ࣮஦ົ
e-mail ࡬ࡢῧ௜࡟࡚ᥦฟࡍࡿࠋ
ὀ㸧ᡤᒓᶵ㛵࣭㒊ᒁ࡟࡚ྲྀᚓࡋࡓ࣓࣮ࣝ࢔ࢻࣞࢫ࡛࠶ࡿࡇ࡜ࠋЎյ ฼⏝チྍ᭩ࢆཷࡅྲྀࡿࠋЎն ฼⏝㛤ጞࠋ
ὀ 1㸧ධ㤋Ⓩ㘓ࡢࡓࡵࠊಶே ID ࡶูᵝᘧ࡟࡚ᥦฟࡋ࡚࠸ࡓࡔࡁࡲࡍࠋ
ὀ 2㸧ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛㸦ᮾᲷ㸧฼⏝⪅ࡣࠊ஦๓࡟ࠕᮾᲷ᪂つ฼⏝⪅ㅮ⩦఍ࠖࡢཷㅮࡀᚲせ࡛ࡍࠋ− 38 −

໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮
ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛㸦ᮾᲷ㸧᪋タ฼⏝ࡢᡭᘬࡁ
㸯㸬฼⏝⏦ㄳ㸦㸯㸧 ᙜ㒊㛛㸦ᮾᲷ㸧㣫⫱ᐊ࣭ᐇ㦂ᐊ➼ࡢ฼⏝ࢆᕼᮃࡍࡿ᫬ࡣࠊ㟁ヰ࠿㟁Ꮚ࣓࣮࡛ࣝᚲࡎ஦๓࡟
ࡈ㐃⤡ࡃࡔࡉ࠸⅛
㸦㸰㸧 ◊✲ᐊࡈ࡜࡟฼⏝⏦ㄳ᭩ཬࡧ฼⏝⪅ྡ⡙࡬ᚲせ஦㡯ࢆグධࡋࠊᥦฟࡋ࡚࠸ࡓࡔࡁࡲࡍࠋ
฼⏝チྍ᭩㸦༢ᖺᗘ㸧ࢆ⤒㈝ࡢᨭᡶ㈐௵⪅ᐄ࡟Ⓨ⾜࠸ࡓࡋࡲࡍࠋ㸦㸱㸧 㑇ఏᏊ⤌᥮࠼ᐇ㦂ࡸື≀ᐇ㦂ࢆ⾜࠺᪉ࡣᏛෆࡢ࣮ࣝࣝ࡟ᚑࡗ࡚⏦ㄳࢆ⾜࠸ࠊࡑࡢチྍ␒ྕࡲࡓࡣᢎㄆ␒ྕࢆୖグ㸦㸰㸧฼⏝⏦ㄳ᭩࡟グ㍕ࡍࡿᚲせࡀ࠶ࡾࡲࡍࠋ㸦㸲㸧 ᪂つ฼⏝⪅ࡀᙜ㒊㛛ࡢධ㤋ࢩࢫࢸ࣒࡬Ⓩ㘓ࢆᕼᮃࡉࢀࡿሙྜࡣࠊ⌮Ꮫ◊✲㝔ࡢᐃࡵࡿ᭩ᘧ
࡛ࡢ⏦ㄳࡶ࠾㢪࠸ࡋࡲࡍࠋࡲࡓࠊᙜ㒊㛛୺ദࡢ฼⏝⪅ㅮ⩦఍ࡢཷㅮࡶ⩏ົ௜ࡅ࡚࠾ࡾࡲࡍࡢ
࡛ࠊᛀࢀࡎ࡟ཷㅮࡋ࡚ࡃࡔࡉ࠸ࠋ
㸦㸳㸧฼⏝⏦ㄳᡭ⥆ࡁࡣ㝶᫬ཷࡅ௜ࡅࡲࡍࠋ
㸦㸴㸧⥅⥆ࡋ࡚฼⏝ࡉࢀࡿሙྜࡢᖺᗘẖࡢ᭦᪂ᡭ⥆ࡁࡣ୙せ࡛ࡍࠋࡓࡔࡋࠊୖグ㸦㸰㸧࡟࠾࠸࡚
ᥦฟࡋࡓෆᐜ࡟ኚ᭦ࡸ㏣ຍࡀ⏕ࡌࡓሙྜ࡟ࡣᚲせ᭩㢮ࡢ෌ᥦฟࡋ࡚࠸ࡓࡔࡁࡲࡍࡢ࡛ࠊ⫋ဨࡢᣦ♧ࢆ௮࠸࡛ࡃࡔࡉ࠸ࠋ
㸦㸵㸧ୖグ㸦㸴㸧࡟࠾࠸࡚฼⏝⪅ྡ⡙࡟᪂ࡓ࡟㏣ຍࡉࢀࡓ⪅ࡣ㸦㸲㸧࡟ヱᙜࡋࡲࡍࡢ࡛ࠊྠᵝࡢᡭ⥆ࡁཬࡧ฼⏝⪅ㅮ⩦఍ࡢཷㅮࢆ࠾㢪࠸ࡋࡲࡍࠋ
㸦㸶㸧฼⏝ࢆ⤊஢ࡉࢀࡿሙྜ࡟ࡣᥦฟ᭩㢮ࡣ࠶ࡾࡲࡏࢇࡀࠊ᧔㏥ࡉࢀࡿ㸰㐌㛫๓ࡲ࡛࡟㐃⤡ࢆ࠾㢪࠸ࡋࡲࡍࠋ฼⏝ᩱ㔠ࡣ᭶༢఩࡛࠶ࡿⅬ࡟ࡈὀពࡃࡔࡉ࠸ࠋ
㸰㸬ࡆࡗṑ㢮㣫⫱ᐊ㸦㸯㸧ࡆࡗṑ㢮㣫⫱ᐊ࡟ධᐊࡢ㝿ࡣࠊ㜵␿ୖࠊᚲࡎⓑ⾰ࢆ╔⏝ࡋᑓ⏝ࡢୖᒚࡁ࡬ᒚࡁ᭰࠼࡚ࡃࡔ ࡉ࠸ࠋ㸦㸰㸧ࡆࡗṑ㢮㣫⫱ᐊ࡬ࡢື≀ࡢᦙධ࣭ᦙฟࡣࠊ㣫⫱㒊ᢸᙜ⫋ဨࡢᣦ♧࡟ᚑࡗ࡚ࡃࡔࡉ࠸ࠋ
㸦㸱㸧㸦ᐇ㦂⏝ື≀ࡢ౪⤥㸧  ᙜ㒊㛛࡛ࡣࠊࣛࢵࢺ࣭࣐࢘ࢫ➼ࡢᐇ㦂⏝ື≀ࡢ౪⤥ࢆ⾜ࡗ࡚࠾ࡾࡲࡍࠋ౪⤥ᕼᮃ⪅ࡣࠊู⾲㸰ࡢࠕᐇ㦂⏝ື≀౪⤥⣽๎ࠖ࡟ᚑࡗࡓᚲせᡭ⥆ࢆ῭ࡲࡏ࡚ࡃࡔࡉ࠸ࠋ
㸦㸲㸧㸦ື≀ࡢ㣫⫱㸧− 39 −  ື≀ࡢ⤥㣵࣭⤥Ỉ࣭ᗋᩜࡢ஺᥮ࡣࠊ฼⏝⪅ࡀ⾜ࡗ࡚ࡃࡔࡉ࠸ࠋ
㸦㸳㸧㸦࢚ࢧࠊᗋᩜ㸧     㣫⫱࡟ᚲせ࡞࢚ࢧཬࡧᗋᩜࡣ฼⏝⪅ࡀ⏝ពࡋ࡚ࡃࡔࡉ࠸ࠋࡓࡔࡋࠊᙜ㒊㛛࡛ࡶࡆࡗṑ㢮⏝ࡢ࢚ࢧ㸯⿄  ਻ࠊᗋᩜ㸯⿄  ਻ࢆᐇ㈝࡛࠾ศࡅ࡛ࡁࡲࡍࠋ
㸦㸴㸧㸦ᚤ⏕≀ࣔࢽࢱࣜࣥࢢ⾲ࡢᥦฟ㸧  㣫⫱ᐊ࡟࠾ࡅࡿఏᰁ⑓⶝ᘏࢆண㜵ࡍࡿࡓࡵࠊእ㒊ࡢᶵ㛵࠿ࡽᦙධࡋࡓື≀ࢆ㣫⫱ࡍࡿሙྜ
ࡣࠊᦙධࡍࡿື≀ࡀᙜ㒊㛛ࡢࠕᶆ‽సᴗᡭ㡰᭩ࠖ࡟つᐃࡍࡿ⑓ཎయ࡟ឤᰁࡋ࡚࠸࡞࠸ࡇ࡜ࢆ
ド᫂ࡍࡿ᭩㢮㸦ᚤ⏕≀ࣔࢽࢱࣜࣥࢢ⾲㸧ࢆணࡵᥦฟࡋ࡚ࡃࡔࡉ࠸ࠋࡓࡔࡋࠊᦙධ๓㸯ᖺ௨ෆ࡟ྠࡌᶵ㛵࠿ࡽྠ✀ࡢື≀ࢆᦙධࡋࡓ㝿࡟ᚤ⏕≀ࣔࢽࢱࣜࣥࢢ⾲ࢆᥦฟࡋࡓሙྜ࡟ࡣࠊᨵࡵ
࡚ᥦฟࡍࡿᚲせࡣ࠶ࡾࡲࡏࢇࠋ
㸦㸵㸧㸦ࡆࡗṑ㢮ฎ⨨ᐊࡢ฼⏝㸧  ࡆࡗṑ㢮㣫⫱ᐊࡢ฼⏝⪅ࡣࠊᙜ㒊㛛ෆ࡛㣫⫱ࡍࡿື≀࡬ࡢᐇ㦂ⓗฎ⌮ࢆ⾜࠺ࡓࡵ࡟ฎ⨨ᐊࢆ฼⏝ࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋ฼⏝ࡋࡓ࠸ሙྜࡣ஦๓࡟✵ࡁ≧ἣࢆᢸᙜ⪅࡟☜ㄆࡋࠊ฼⏝ᕼᮃ᪥᫬࡜ฎ⨨ෆᐜࢆᢸᙜ⪅࡬࠾ఏ࠼ࡃࡔࡉ࠸ࠋ
㸱㸬࢞ࣛࢫᐊ࣭ᅡሙ
㸦㸯㸧ᘓ≀㸯㸰㝵࡟௜ᒓࡋࡓ࢞ࣛࢫᐊࠊཬࡧᒇእ࡟ᅡሙࡀ⏝ពࡉࢀ࡚࠸ࡲࡍࠋ฼⏝ࢆᕼᮃࡍࡿ㝿࡟ࡣ஦๓࡟ᢸᙜ⫋ဨ࡜฼⏝᪉ἲࢆᡴࡕྜࢃࡏࡓ࠺࠼࡛฼⏝⏦ㄳࢆࡋ࡚ࡃࡔࡉ࠸ࠋ
㸦㸰㸧฼⏝༊ᇦࡢ㝖ⲡࡸΎᤲࡣ฼⏝⪅ྛ⮬࡛⾜ࡗ࡚ࡃࡔࡉ࠸ࠋ㎰ල㢮ࡢ㈚ฟࡶ⾜ࡗ࡚࠸ࡲࡍࡢ࡛ࠊ
฼⏝ࡢ㝿࡟ࡣ⫋ဨ࡬⏦ࡋฟ࡚ࡃࡔࡉ࠸ࠋ
㸦㸱㸧᱂ᇵᗫᲠ≀ࡣᏛෆࡢᗫᲠ≀ฎ⌮᪉ἲ࡟ᚑࡗ࡚ฎศࡋ࡚ࡃࡔࡉ࠸ࠋ
㸲㸬Ỉᵴᐊ
㸦㸯㸧Ỉᵴᐊ࡟ࡣࠊ ᗘࢥࣥࢺ࣮࣮ࣟࣛ௜ࡢỈᵴࡀ⏝ពࡉࢀ࡚࠸ࡲࡍࠋࡲࡓࠊ㣫⫱Ỉ࡜ࡋ࡚஭Ỉ㸦㞧⏝Ỉ㸧࡜ᾏỈࢆ฼⏝࡛ࡁࡲࡍࠋ
㸦㸰㸧฼⏝⪅ࡣࠊ༙ᖺ࡟୍ᗘࠊỈᵴ࡜᤼Ỉ⁁ࡢᤲ㝖୪ࡧ࡟ℐ㐣◁ࡢὙίࢆ⾜ࡗ࡚ࡃࡔࡉ࠸ࠋࡲࡓࠊ
Ỉᵴࡢ฼⏝ࡀ⤊஢ࡋࡓሙྜࡶྠᵝ࡛ࡍࠋ㸳㸬ඹྠ฼⏝㸦㸯㸧฼⏝⪅ࡣࠊᙜ㒊㛛ࢆ฼⏝ࡋ࡚⾜࠺ᐇ㦂࣭◊✲ࡢ㐙⾜ୖࠊᚲせ࡜ㄆࡵࡽࢀࡿసᴗ࡟ࡘ࠸࡚ࠊ
ඹྠ฼⏝ᶵჾ㸦ู⾲㸯ཧ↷㸧ࢆ฼⏝ࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋᕼᮃ⪅ࡣ⏦ㄳ᭩ࠕ฼⏝ᶵჾࠖḍ࡟

− 40 −

௜グࡋࠊ฼⏝᪉ἲࢆ⫋ဨ࡟☜ㄆࡋ࡚࠿ࡽࡈ฼⏝ࡃࡔࡉ࠸ࠋ
㸦㸰㸧㒊㛛ෆ࡛ࡢ㣫⫱࣭ᐇ㦂ࡢࡓࡵ୍᫬ⓗ࡟㣫ᩱㄪᩚᐊࢆ฼⏝ࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋ౑⏝ᚋࡣᤲ㝖࣭ࢦ࣑ฎ⌮➼ࢆ⾜࠸ࠊඖࡢ≧ែ࡟ᡠࡋ࡚ࡃࡔࡉ࠸ࠋ
㸦㸱㸧㣫⫱࣭ᐇ㦂࡟⏝࠸ࡓ⬨᳝ື≀ࡢṚయࡣࠊᑓ⏝ࣇ࣮ࣜࢨ࣮࡟ᗫᲠࡋグ㘓⡙࡬ᩘ㔞➼ࢆグධࡋ
࡚ࡃࡔࡉ࠸ࠋ
㸦㸲㸧฼⏝⪅ࡀ㝶᫬฼⏝ሙᡤࢆΎᤲ࡛ࡁࡿࡼ࠺ࠊᤲ㝖㐨ලࡢ㈚ࡋฟࡋࢆ⾜ࡗ࡚࠾ࡾࡲࡍࠋ⫋ဨ࡟ࡈ┦ㄯ࠸ࡓࡔࡃ࠿ࠊ㸰㝵ᗯୗ࡟࠶ࡿࣟࢵ࣮࢝ࡢᤲ㝖㐨ලࢆࡈ౑⏝ࡃࡔࡉ࠸ࠋ
㸦㸳㸧Ᏻ඲࢟ࣕࣅࢿࢵࢺࠊ&2 ࢖࣮ࣥ࢟ࣗ࣋ࢱ➼ࡀタ⨨ࡋ࡚࠶ࡿඹྠ฼⏝ᐊࢆ฼⏝ࡍࡿሙྜࠊ฼⏝⏦ㄳ᭩࡬ࡢグ㍕ࡀᚲせ࡛ࡍࠋᐇ㦂࡟ᚲせ࡞ᾘ⪖ရࡣ฼⏝⪅ࡀ⏝ពࡋ㐺ษ࡟ᗫᲠࡋ࡚ࡃࡔࡉ࠸ࠋタ⨨ᶵჾ㢮ࡢ฼⏝᫬㛫ࡸሙᡤ➼࡟㛵ࡋ࡚ࡣ฼⏝⪅ྠኈࡀヰࡋྜ࠸ㄪᩚࡋ࡚ࡃࡔࡉ࠸ࠋ᪂ࡓ࡟
ᶵჾ➼ࢆ฼⏝ᐊ࡟ᣢࡕ㎸ࡴሙྜࠊ๓ࡶࡗ࡚⫋ဨࡲ࡛࠾▱ࡽࡏࡃࡔࡉ࠸ࠋ
㸴㸬✵ㄪ➼ࡢ␗ᖖ࣭ࢺࣛࣈࣝ
㸦㸯㸧ྛᐊ࡟࠶ࡿ✵ㄪไᚚ┙ࡣᡤᐃࡢタᐃ್࡟ࢭࢵࢺࡉࢀ࡚࠸ࡲࡍࡢ࡛ࠊኚ᭦ࢆᕼᮃࡍࡿሙྜࡣ ᚲࡎ⏦ࡋฟ࡚ࡃࡔࡉ࠸ࠋ
㸦㸰㸧ྛᐊࡢ㆙ሗタᐃ ᗘ㸦ୖ㝈࣭ୗ㝈㸧ࡣᙜ㒊㛛⫋ဨࡢ᪉࡛タᐃࡋࡲࡍࡀࠊ฼⏝ࡋ࡚࠸ࡿ㒊ᒇ࡟ࡘ࠸࡚≉࡟ᕼᮃࡀ࠶ࡿሙྜ࡟ࡣࡈ┦ㄯࡃࡔࡉ࠸ࠋ
㸦㸱㸧ᐊࡢ␗ᖖࢆ▱ࡽࡏࡿ㆙ሗ┙ࡀࠊ㸯㝵⋞㛵࣮࣍ࣝ࡜㸰㝵ᮾഃᗯୗ୰ኸཬࡧ㸰㝵ᮾഃᗯୗࡢ

໭➃࡟ഛࢃࡗ࡚࠸ࡲࡍࠋ㆙ሗࡀ㬆ࡗ࡚࠸ࡿ࡜ࡁࡣ⫋ဨ࡬㐃⤡㢪࠸ࡲࡍࠋ
㸦㸲㸧⫋ဨ୙ᅾࡢ᫬㛫ᖏ࡟㆙ሗࡀ㬆ࡗ࡚࠸ࡓࡾࢺࣛࣈࣝ࡟㐼㐝ࡋࡓࡾࡋࡓ㝿ࡣࠊ⌮Ꮫ㒊㸰ྕ㤋ࡢ㜵⅏ࢭࣥࢱ࣮㸦ෆ⥺ 㸧࡬ఏ࠼࡚ࡃࡔࡉ࠸ࠋ㸵㸬೵㟁㸦㸯㸧ᙜ㒊㛛࡟ࡣ೵㟁࡟ࡼࡿ⏕≀ཬࡧᐇ㦂⣔࡬ࡢᙳ㡪ࢆ᭱ᑠ㝈࡟㣗࠸Ṇࡵࡿࡓࡵࠊ✵ㄪ࡞࡝࡬ࡢᚲせ᭱ప㝈ࡢᶵჾࡢ㐠㌿ࢆಖドࡍࡿ⮬ᐙⓎ㟁⿦⨨ࡀഛࢃࡗ࡚࠸ࡲࡍࠋ
㸦㸰㸧⮬ᐙⓎ㟁⿦⨨ࡣ୍᫬ⓗ࡞㟁ຊ౪⤥ࡋ࠿࡛ࡁࡲࡏࢇࡢ࡛ࠊ஦๓࡟೵㟁ࡀ▱ࡽࡉࢀ࡚࠸ࡿሙྜ
ࡣ೵㟁๓࡟ᚲࡎྛᶵჾࡢ㟁※ࢆษࡗ࡚ࡃࡔࡉ࠸ࠋ
㸦㸱㸧೵㟁࡟ࡣ᩿Ỉࡀక࠺ሙྜࡀ࠶ࡾࡲࡍࠋ⤥Ỉ࣭⤥‫ࡈࡣ⏝౑ࡢࣞ࢖ࢺࡧཬ‮‬㐲៖ࡃࡔࡉ࠸ࠋ
㸦㸲㸧⥭ᛴ࡟೵㟁ࡀⓎ⏕ࡍࡿ࡜ᩘ⛊ᚋ࡟⮬ᐙⓎ㟁⿦⨨ࡀసືࡋࡲࡍࠋᩘศ⤒ࡗ࡚ࡶ㏻㟁ࡋ࡞࠸➼ࡢࢺࣛࣈࣝࡀ࠶ࡗࡓሙྜ࡟ࡣ⮳ᛴ⫋ဨ࡬㐃⤡㢪࠸ࡲࡍࠋ㸦⫋ဨ୙ᅾ᫬ࡣ㸴㸬㸦㸲㸧࡜ྠᵝ࡟ᑐ− 41 −

ᛂࡋ࡚ࡃࡔࡉ࠸ࠋ㸧㸶㸬⣧Ỉࠊ㉸⣧ỈࠊᾏỈ㸦㸯㸧ᙜ㒊㛛࡛ࡣࠊ⣧Ỉ㸦52㸧ࠊ㉸⣧Ỉ㸦࣑ࣜ 4㸧ࠊᾏỈࡢࡳࡢᥦ౪ࡶ⾜ࡗ࡚࠸ࡲࡍࠋᕼᮃ⪅ࡣ౯᱁ࢆ☜ㄆࡋࠊ฼⏝⏦ㄳ᭩ࢆᥦฟࡋ࡚ࡃࡔࡉ࠸ࠋ
㸦㸰㸧౑⏝ࡢ㝿࡟ࡣᚲせ㔞ศࡢᐜჾࢆᣢཧࡋࠊᡤᐃࡢ⏝⣬࡟グධࡋ࡚ࡈ฼⏝ࡃࡔࡉ࠸ࠋ
㸷㸬⤒㈝
㸦㸯㸧✵ㄪࠊࡑࡢ௚ㅖタഛࡢ⥔ᣢ࣭⟶⌮ࡢࡓࡵࡢㅖ⤒㈝ࡢ୍㒊࡜ඹ㏻ᾘ⪖ရࡢ㈝⏝࡜ࡋู࡚࡟ᐃ
ࡵࡿᩱ㔠ࢆ฼⏝⪅࡟㈇ᢸࡋ࡚࠸ࡓࡔࡁࡲࡍࠋ࡞࠾ࠊ฼⏝ᩱ㔠ࡣᖺᗘጞࡵ࠿ࡽ㸱ࣨ᭶ẖ࡟ᚩ཰ࡉࡏ࡚࠸ࡓࡔࡁࡲࡍࠋ
㸯㸮㸬ࡑࡢ௚
㸦㸯㸧ධ㤋ࡍࡿ㝿࡟Ⓩ㘓 ,& ࣮࢝ࢻࢆᚲࡎᦠᖏࡋ࡚ୗࡉ࠸ࠋ
㸦㸰㸧ᙜ㒊㛛ෆࡣᅵ㊊⚗Ṇ࡛ࡍࡢ࡛ࠊᑓ⏝ࡢୖᒚࡁࢆࡈ฼⏝ࡃࡔࡉ࠸ࠋ
㸦㸱㸧฼⏝⪅ࡀⓎὀࡋࡓᶵჾಟ⧋࣭≀ရࢆ┤᥋ᙜ㒊㛛࡬⣡ရࡍࡿ㝿ࡣࠊ஦๓࡟⣡ရᴗ⪅࡜⣡ရ᪥ࢆ⫋ဨ࡬㐃⤡ࡋࠊᦙධࡸసᴗࡢ᪥᫬ࡢㄪᩚࢆ⾜ࡗ࡚ࡃࡔࡉ࠸ࠋ㸦㸲㸧 ᙜ㒊㛛ෆ࡛ࡢ≀ရࡢᢅ࠸࡟ࡘ࠸࡚ࡣࠊ௨ୗࡢⅬ࡟ᚚὀពࡃࡔࡉ࠸ࠋ∝ ≀ရ࡟ࡣ඲࡚ᡤ᭷⪅࣭ᡤᒓㅮᗙ࡞࡝ࢆศ࠿ࡾࡸࡍ࠸ሙᡤ࡟᫂グࡋ࡚ࡃࡔࡉ࠸ࠋ
∝ ഛရ␒ྕࡀࡘ࠿࡞࠸ჾල࣭ᶵჾ࣭ᾘ⪖ရ࡟ࡘ࠸࡚ࡶᡤᒓࡀศ࠿ࡿࡼ࠺࡟ㅮᗙྡ➼ࢆࡈグධࡃࡔࡉ࠸ࠋ
∝ ኱ࡁ࡞㈨ᮦࡸ≀ရࢆฟࡋධࢀࡍࡿ㝿࡟ࡣࠊ஦๓࡟⫋ဨ࡬㐃⤡ࡋࠊ㐺ᐅ⏦ㄳ᭩ࡢ᭩ࡁ᥮࠼
ࢆ⾜ࡗ࡚ࡃࡔࡉ࠸ࠋ∝ ⏦ㄳࡢ㝿࡟฼⏝ሙᡤ࡜ࡋ࡚᫂グࡉࢀ࡚࠸࡞࠸ሙᡤ㸦౛࠼ࡤ⮬ศࡢ౑⏝ሙᡤ௨እࡢ㒊ᒇ࣭ᗯୗ࣭⋞㛵➼㸧࡟୍᫬ⓗ࡟࡛ࡶ≀ရࢆタ⨨ࡍࡿሙྜ࡟ࡣࠊ⫋ဨࡲ࡛ࡈ㐃⤡ࡃࡔࡉ࠸ࠋ
㸦㸳㸧฼⏝ࢆ⤊஢ࡍࡿ㝿࡟ࡣࠊ㒊ᒇ࣭ᶵჾ➼ࢆඖࡢ≧ែ࡟ᡠࡋࠊ⫋ဨࡢ☜ㄆࢆཷࡅ࡚ࡃࡔࡉ࠸ࠋ
㸦㸴㸧ᙜ㒊㛛㐠Ⴀ㈝ࡢ୍㒊ࡣࠊⓙᵝ࠿ࡽࡢ฼⏝ᩱ㔠࡟ࡼࡗ࡚㈥ࢃࢀ࡚࠸ࡲࡍࠋග⇕Ỉᩱࡣ㐠Ⴀ㈝⥲㢠ࡢከࡃࢆ༨ࡵ࡚࠾ࡾࠊᙜ㒊㛛ࢆ㐠Ⴀࡍࡿ࠺࠼࡛㈇ᢸ࡜࡞ࡗ࡚࠾ࡾࡲࡍࠋᙜ㒊㛛ࢆඹྠ฼⏝᪋タ࡜ࡋ࡚ࡼࡾ୍ᒙά⏝ࡍࡿࡓࡵ࡟ࡶࠊ㟁Ẽ࣭Ỉ㐨➼ࡢ↓㥏౑࠸ࢆ࡞ࡃࡋࠊ┬࢚ࢿࣝࢠ࣮໬ࢆᚰ᥃ࡅ࡚ࡃࡔࡉ࠸ࠋ

− 42 −ู⾲㸯ඹྠ฼⏝ᶵჾ
࣮࢜ࢺࢡ࣮ࣞࣈ㸦ඹྠᐇ㦂ᐊ㸧   ஝⇕⁛⳦ᶵ㸦ඹྠᐇ㦂ᐊ㸧    〇ịჾ㸦㣫ᩱㄪᩚᐊ㸧&2 ࢖࣮ࣥ࢟ࣗ࣋ࢱ㸦ඹྠᐇ㦂ᐊ㸧Ᏻ඲࢟ࣕࣅࢿࢵࢺ㸦ඹྠᐇ㦂ᐊ㸧㸫Υࣇ࣮ࣜࢨ࣮㸦୰ᗯୗ㸧




ู⾲㸰
ᐇ㦂⏝ື≀౪⤥⣽๎㸬 ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛࡟࠾ࡅࡿ࣐࢘ࢫ࣭ࣛࢵࢺࡢ౪⤥࡟ࡘ࠸࡚ࡣࠊࡇࡢ⣽๎ࡢᐃࡵࡿ࡜ࡇࢁ࡟ࡼࡿࠋ㸬 ᐇ㦂⏝ື≀ࡣࠊཎ๎࡜ࡋ࡚◊✲ᐇ㦂⏝࡟౪⤥ࡍࡿࠋ㸬 ᐇ㦂⏝ື≀ࡢ㣫⫱⤒㈝ࡢ㈇ᢸࡣࠊḟࡢ࡜࠾ࡾ࡜ࡍࡿࠋ
ࣁࢶ࢝ࢿࢬ࣑  ⣔⤫ࠊᛶูࠊ㐌㱋ࡢ㸦࣐࢘ࢫ㸧ᣦᐃ᭷ࡾ  㢌ᙜࡓࡾ   ෇    ᣦᐃ↓ࡋ  㢌ᙜࡓࡾ   ෇ዷፎಶయ  㢌ᙜࡓࡾ  ෇ࢻࣈࢿࢬ࣑  ⣔⤫ࠊᛶูࠊ㐌㱋ࡢ㸦ࣛࢵࢺ㸧 ᣦᐃ᭷ࡾ  㢌ᙜࡓࡾ  ෇     ᣦᐃ↓ࡋ  㢌ᙜࡓࡾ   ෇ዷፎಶయ  㢌ᙜࡓࡾ  ෇ 㸬 ౪⤥ࡢ⏦㎸ࡳࡣࠊணࡵࡆࡗṑ㢮㣫⫱㒊ࡢᢸᙜ⫋ဨ࡜ᡴྜࡏࢆ⾜࠸ࠊᡤᐃࡢ⏝⣬࡟ᚲせ஦㡯ࢆグධࡢୖࠊ⾜࠺ࡇ࡜ࠋ㸬 㸬࡟つᐃࡍࡿ㈝⏝ࡢㄳồࡣࠊᐇ㦂⏕≀ඹྠ฼⏝㒊㛛ࡢ฼⏝ᩱࡢㄳồ࡟ྜࢃࡏ࡚
⾜࠺ࠋ౪⤥࡟㝿ࡋ࡚ᚲせ࡜࡞ࡿ㈝⏝࡟ࡘ࠸࡚ࡣࠊ⏦㎸⪅ࡀ㈇ᢸࡍࡿࠋ
− 43 −

໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮つ⛬ᖹᡂ㸰㸮ᖺ㸯㸯᭶㸯᪥ᾏ኱㐩➨㸯㸳㸮ྕ 㸦㊃᪨㸧➨㸯᮲ ࡇࡢつ⛬ࡣ㸪ᅜ❧኱Ꮫἲே໭ᾏ㐨኱Ꮫ⤌⧊つ๎㸦ᖹᡂ㸯㸴ᖺᾏ኱㐩➨㸱㸯ྕ㸧➨㸰㸵᮲ࡢ㸵➨㸲㡯ࡢつᐃ࡟ᇶ࡙ࡁ㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡ
ࢫ◊✲ࢭࣥࢱ࣮㸦௨ୗࠕࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ
㸧ࡢ⤌⧊ཬࡧ㐠Ⴀ࡟ࡘ࠸࡚ᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ 㸦┠ⓗ㸧➨㸰᮲ ࢭࣥࢱ࣮ࡣ㸪໭ᾏ㐨኱Ꮫࡢ◊✲⪅࡟ᑐࡋ࡚㸪㑇ఏᏊཬࡧᰁⰍయ࡟㛵ࡍࡿ◊✲ࢆ⾜࠺ࡓࡵࡢ᪋タཬࡧタഛࢆᥦ౪ࡍࡿ࡜࡜ࡶ࡟㸪ື≀㸪᳜≀ࡑࡢ௚⏕≀ᮦᩱࡢ౪⤥ࢆ⾜࠺ࡇ࡜࡟ࡼࡾ㸪⏕≀⛉Ꮫศ㔝ࡢ◊✲ࡢ㐍ᒎ࡟ᐤ୚ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ 㸦ඹྠ฼⏝㒊㛛㸧➨㸱᮲ ࢭࣥࢱ࣮࡟㸪ḟ࡟ᥖࡆࡿඹྠ฼⏝㒊㛛ࢆ⨨ࡃࠋ  ື≀ᰁⰍయඹྠ฼⏝㒊㛛  㑇ఏᏊᐇ㦂ඹྠ฼⏝㒊㛛  ᐇ㦂⏕≀ඹྠ฼⏝㒊㛛 㸦⫋ဨ㸧➨㸲᮲ ࢭࣥࢱ࣮࡟㸪ࢭࣥࢱ࣮㛗ࡑࡢ௚ᚲせ࡞⫋ဨࢆ⨨ࡃࠋ 㸦ࢭࣥࢱ࣮㛗㸧➨㸳᮲ ࢭࣥࢱ࣮㛗ࡣ㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔ࡢᑓ௵ࡢᩍᤵཪࡣ෸ᩍᤵࢆࡶࡗ࡚඘࡚ࡿࠋ㸰 ࢭࣥࢱ࣮㛗ࡣ㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㛗㸦௨ୗࠕ◊✲㝔㛗ࠖ࡜࠸࠺ࠋ㸧ࡢ┘╩ࡢୗ࡟㸪ࢭࣥࢱ࣮ࡢᴗົࢆᤸ⌮ࡍࡿࠋ㸱 ࢭࣥࢱ࣮㛗ࡢ௵ᮇࡣ㸰ᖺ࡜ࡍࡿࠋ㸲 ࢭࣥࢱ࣮㛗ࡣ㸪෌௵ࡉࢀࡿࡇ࡜ࡀ࡛ࡁࡿࠋ㸳 ࢭࣥࢱ࣮㛗ࡢ㑅⪃ࡣ㸪◊✲㝔㛗ࡀ᥎⸀ࡍࡿೃ⿵⪅࠿ࡽ㸪⥲㛗ࡀ⾜࠺ࠋ㸴 ࢭࣥࢱ࣮㛗ೃ⿵⪅ࡢ㑅⪃࡟ࡘ࠸࡚ࡣ㸪◊✲㝔㛗ࡀู࡟ᐃࡵࡿࠋ 㸦㐠Ⴀጤဨ఍㸧➨㸴᮲ ࢭࣥࢱ࣮࡟㸪ࢭࣥࢱ࣮ࡢඹྠ฼⏝࡟㛵ࡍࡿ஦㡯ࡑࡢ௚ࡢࢭࣥࢱ࣮ࡢ㐠Ⴀ࡟㛵ࡍࡿ㔜せ஦㡯ࢆᑂ㆟ࡍࡿࡓࡵ㸪㐠Ⴀጤဨ఍ࢆ⨨ࡃࠋ㸰 㐠Ⴀጤဨ఍ࡢ⤌⧊ཬࡧ㐠Ⴀ࡟ࡘ࠸࡚ࡣ㸪◊✲㝔㛗ࡀู࡟ᐃࡵࡿࠋ 㸦㞧๎㸧➨㸵᮲ ࡇࡢつ⛬࡟ᐃࡵࡿࡶࡢࡢ࡯࠿㸪ࢭࣥࢱ࣮ࡢ⤌⧊ཬࡧ㐠Ⴀ࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪◊✲㝔ࡢᩍᤵ఍ࡢ㆟ࢆ⤒࡚㸪◊✲㝔㛗ࡀู࡟ᐃࡵࡿࠋ   㝃 ๎㸯 ࡇࡢつ⛬ࡣ㸪ᖹᡂ㸰㸮ᖺ㸯㸯᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ㸰 ࡇࡢつ⛬ࡢ᪋⾜ᚋ㸪᭱ึ࡟௵࿨ࡉࢀࡿࢭࣥࢱ࣮㛗ࡢ௵ᮇࡣ㸪➨㸳᮲➨㸱㡯ࡢつᐃ࡟࠿࠿ࢃࡽࡎ㸪ᖹᡂ㸰㸰ᖺ㸱᭶㸱㸯᪥ࡲ࡛࡜ࡍࡿࠋ   㝃 ๎ ࡇࡢつ⛬ࡣ㸪ᖹᡂ㸰㸯ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ   㝃 ๎ ࡇࡢつ⛬ࡣ㸪ᖹᡂ㸰㸵ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ− 44 −

໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㐠Ⴀጤဨ఍ෆつ 㸦㊃᪨㸧
➨㸯᮲ ࡇࡢෆつࡣ㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮つ⛬㸦ᖹᡂ  ᖺᾏ኱㐩➨  ྕ㸧➨㸴᮲➨㸰㡯ࡢつᐃ࡟ᇶ࡙ࡁ㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㐠Ⴀጤဨ఍㸦௨ୗࠕጤဨ఍ࠖ࡜࠸࠺ࠋ㸧ࡢ⤌⧊ཬࡧ㐠Ⴀ࡟ࡘ࠸࡚ᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ 㸦ᑂ㆟஦㡯㸧➨㸰᮲ ጤဨ఍ࡣ㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㸦ḟ᮲➨㸯㡯࡟࠾࠸࡚ࠕࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ
㸧ࡢඹྠ฼⏝࡟㛵ࡍࡿ஦㡯ࡑࡢ௚ࡢࢭࣥࢱ࣮ࡢ㐠Ⴀ࡟㛵ࡍࡿ㔜せ஦㡯ࢆᑂ㆟ࡍࡿࠋ 㸦⤌⧊㸧
➨㸱᮲ ጤဨ఍ࡣ㸪ḟ࡟ᥖࡆࡿ⪅ࢆࡶࡗ࡚⤌⧊ࡍࡿࠋ ࢭࣥࢱ࣮㛗 ࢭࣥࢱ࣮ࡢᴗົࢆවົࡍࡿ໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔ࡢᩍᤵཬࡧ෸ᩍᤵ㸦ᅜ❧኱Ꮫἲே໭ᾏ㐨኱Ꮫ≉௵ᩍဨᑵᴗつ๎㸦ᖹᡂ㸯㸶ᖺᾏ኱㐩➨㸱㸳ྕ㸧➨㸱᮲➨㸰ྕ࡟ヱᙜࡍࡿ≉௵ᩍဨࢆྵࡴ㸧 ࡑࡢ௚⌮Ꮫ◊✲㝔㛗ࡀᚲせ࡜ㄆࡵࡓ⪅ ⱝᖸྡ㸰 ๓㡯➨㸱ྕࡢጤဨࡣ㸪⌮Ꮫ◊✲㝔㛗ࡀጤკࡍࡿࠋ 㸦௵ᮇ㸧
➨㸲᮲ ๓᮲➨㸯㡯➨㸱ྕࡢጤဨࡢ௵ᮇࡣ㸪㸯ᖺ࡜ࡍࡿࠋࡓࡔࡋ㸪⿵Ḟࡢጤဨࡢ௵ᮇࡣ㸪๓௵⪅ࡢṧ௵ᮇ㛫࡜ࡍࡿࠋ㸰 ๓㡯ࡢጤဨࡣ㸪෌௵ࡉࢀࡿࡇ࡜ࡀ࡛ࡁࡿࠋ 㸦ጤဨ㛗㸧
➨㸳᮲ ጤဨ఍࡟ጤဨ㛗ࢆ⨨ࡁ㸪⌮Ꮫ◊✲㝔ࡢ๪⌮Ꮫ◊✲㝔㛗ࡢ࠺ࡕ࠿ࡽ㸪⌮Ꮫ◊✲㝔㛗ࡀᣦྡࡍࡿ⪅ࢆࡶࡗ࡚඘࡚ࡿࠋ
㸦ጤဨ఍ࡢᣍ㞟ཬࡧ㆟㛗㸧➨㸴᮲ ጤဨ㛗ࡣ㸪ጤဨ఍ࢆᣍ㞟ࡋ㸪ࡑࡢ㆟㛗࡜࡞ࡿࠋ㸰 ጤဨ఍ࡣ㸪ጤဨ㛗ࡀᚲせ࡜ㄆࡵࡓሙྜ࡟ᣍ㞟ࡍࡿࡶࡢ࡜ࡍࡿࠋ㸱 ጤဨࡢ㸱ศࡢ㸯௨ୖࡢồࡵࡀ࠶ࡿሙྜ࡟ࡣ㸪ጤဨ㛗ࡣጤဨ఍ࢆᣍ㞟ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ 㸦㆟஦㸧
➨㸵᮲ ጤဨ఍ࡣ㸪ጤဨࡢ㐣༙ᩘࡢฟᖍࡀ࡞ࡅࢀࡤ㆟஦ࢆ㛤ࡁ㸪㆟Ỵࡍࡿࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋ㸰 ጤဨ఍ࡢ㆟஦ࡣ㸪ฟᖍጤဨࡢ㐣༙ᩘࢆࡶࡗ࡚Ỵࡍࡿࡶࡢ࡜ࡍࡿࠋ 㸦ጤဨ௨እࡢ⪅ࡢฟᖍ㸧➨㸶᮲ ጤဨ఍ࡀᚲせ࡜ㄆࡵࡓ࡜ࡁࡣ㸪ጤဨ఍࡟ጤဨ௨እࡢ⪅ࡢฟᖍࢆồࡵ㸪ㄝ᫂ཪࡣព
ぢࢆ⫈ࡃࡇ࡜ࡀ࡛ࡁࡿࠋ

− 45 − 㸦ᗢົ㸧➨㸷᮲ ጤဨ఍ࡢᗢົࡣ㸪⌮Ꮫ࣭⏕࿨⛉Ꮫ஦ົ㒊࡟࠾࠸࡚ฎ⌮ࡍࡿࠋ 㸦㞧๎㸧
➨  ᮲ ࡇࡢෆつ࡟ᐃࡵࡿࡶࡢࡢ࡯࠿㸪ጤဨ఍ࡢ㐠Ⴀ࡟㛵ࡋᚲせ࡞஦㡯ࡣ㸪ጤဨ఍ࡀู࡟ᐃࡵࡿࠋ   㝃 ๎ ࡇࡢෆつࡣ㸪ᖹᡂ㸰㸮ᖺ㸯㸰᭶㸲᪥࠿ࡽ᪋⾜ࡍࡿࠋ   㝃 ๎ࡇࡢෆつࡣ㸪ᖹᡂ㸰㸱ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ− 46 −

໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㛗ೃ⿵⪅㑅⪃ෆつ


㸦㊃᪨㸧
➨㸯᮲ ࡇࡢෆつࡣ㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮つ⛬㸦ᖹᡂ㸰㸮ᖺᾏ኱㐩➨㸯㸳㸮ྕ㸧➨㸳᮲➨㸳㡯ࡢつᐃ࡟ᇶ࡙ࡁ㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮㛗ೃ⿵⪅㸦௨ୗࠕೃ⿵⪅ࠖ㸧ࡢ㑅⪃࡟㛵ࡋ㸪ᚲせ࡞஦㡯࡟ࡘ࠸࡚ᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ
㸦ೃ⿵⪅ࡢ㑅⪃㸧➨㸰᮲ ೃ⿵⪅ࡢ㑅⪃ࡣ㸪ḟࡢ࠸ࡎࢀ࠿࡟ヱᙜࡍࡿሙྜ࡟⾜࠺ࠋ ࢭࣥࢱ࣮㛗ࡢ௵ᮇࡀ‶஢ࡍࡿ࡜ࡁࠋ ࢭࣥࢱ࣮㛗ࡀ㎡௵ࢆ⏦ࡋฟ࡚㸪⥲㛗ࡀㄆࡵࡓ࡜ࡁࠋ ࢭࣥࢱ࣮㛗ࡀḞࡅࡓ࡜ࡁࠋ
㸦ೃ⿵⪅ࡢ㑅⪃㸧➨㸱᮲ ೃ⿵⪅ࡣ㸪⌮Ꮫ◊✲㝔ࡢᑓ௵ࡢᩍᤵཬࡧ෸ᩍᤵࡢ࠺ࡕ࠿ࡽ㸪⌮Ꮫ◊✲㝔㛗ࡀᣦྡࡍࡿ⪅ࢆࡶࡗ࡚඘࡚ࡿࠋ
㸦ᩍᤵ఍ࡢሗ࿌㸧➨㸲᮲ ⌮Ꮫ◊✲㝔㛗ࡣ㸪๓᮲ࡢつᐃ࡟ࡼࡾᣦྡࡉࢀࡓೃ⿵⪅࡟ࡘ࠸࡚㸪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔ᩍᤵ఍࡟ሗ࿌ࡍࡿࡶࡢ࡜ࡍࡿࠋ㝃 ๎ࡇࡢෆつࡣ㸪ᖹᡂ㸰㸮ᖺ㸯㸰᭶㸲᪥࠿ࡽ᪋⾜ࡍࡿࠋ㝃 ๎ࡇࡢෆつࡣ㸪ᖹᡂ㸰㸵ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ− 47 −

໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲㝔㝃ᒓࢤࣀ࣒ࢲ࢖ࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮ ᴫせ2021௧࿴ᖺ᭶Ⓨ⾜
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