GPS Safety Summary Reference No. : JIPS_MSP_OC-0102_JP_EN

GPS/JIPS Safety Summary
1. SUBSTANCE NAME
Ethyl acetate (CAS No. 141-78-6)

2. GENERAL STATEMENT
Ethyl acetate manufactured by our company is a colorless, clear liquid synthesized from acetic
acid and ethylene using a catalyst. It has an aromatic and pungent odor. Evaporation gases isheavier than air and may move along the ground or floor.
Since it is flammable, use of fire, shock, or sparks around ethyl acetate is strictly prohibited duringhandling. The container should be tightly sealed and stored in a well-ventilated cold place.
Also, ethyl acetate may cause pain and itching when it comes into contact with the eyes. If you
may be exposed to ethyl acetate during operation, it is necessary to minimize health effects frominhalation or eye contact by using appropriate exhaust equipment and protective equipment, suchas goggles.

3. CHEMICAL IDENTITY
Item
Chemical or genericname
Trade name
Synonyms
CAS No.
Other No.
Chemical Formula
Structual Formnula

Source/References

Description
Ethyl acetate
Ethyl acetate
Acetic acid ethyl ester
141-78-6
Japan: Chemical Substances Control Law (2)-726
Japan: Industrial Safety and Health Act, existing chemical substance
CH₃COOC₂H₅Section 3 of the SDS issued by Resonac Corporation

4. USES AND APPLICATIONS
Main uses

Ethyl acetate is used for solvents such as printing inks, thinners, andadhesives.

5. PHYSICAL/CHEMICAL PROPERTIES
Ethyl acetate is a colorless liquid at ordinary temperature and pressure. It has an aromatic odor,
and at a high concentration, it has a pungent odor. It is flammable and may generate toxic gases
due to combustion.
Appearance
LiquidColour
ColourlessOdour
Aromatic and pungent at high concentration
Melting point/Boiling point-84 ℃ / 77.1 ℃
Flash point-4 ℃(Closed cup)
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Flammability (solid, gas)
Explosive limits (vol %)Auto-ignition temperature
Vapour pressure
Relative vapour density at20 ℃
Relative density
Solubility in water
Partitioncoefficientnoctanol/water (Log Pow)
Viscosity
Other data
Sources/references

Highly flammable liquid and vapour.
2.2 – 11.5 vol %427 ℃
10 kPa (at 20 ℃)
3.0 (Air=1)
0.901 (20/4℃)
8.1wt% (at 20 ℃)
0.73
0.449 mPa·s (20℃)
Incomplete combustion can release dangerous carbon monoxide,
carbon dioxide and other harmful toxic gases.
Section 9 and 10 of the SDS issued by Resonac Corporation

6. HEALTH EFFECTS
Effect assessment
Acute toxicity (oral)
Acute toxicity (dermal)
Acute toxicity (inhalation:gas)
Acute toxicity (inhalation:vapour)
Acute toxicity (inhalation:dust,mist)
Skin corrosion/irritation
Serious eye damage/eye irritation,
Respiratory sensitisation
Skin sensitisation
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
Specific target organ toxicity — Single exposure,Specific target organ toxicity — Single exposure,Specific target organ toxicity (repeatedexposure)
Aspiration hazard
Referencese

Results （GHS Hazard Classification）
Not classified
Not classified
Not applicable
Category 4 Harmful if inhaled.
Classification not possible
Not classified
Category 2B Causes eye irritation.
Classification not possible
Not classified
Classification not possible
Classification not possible
Classification not possible
Category 3 (Narcosis) May cause drowsinessor dizziness.
Category 3 (Respiratory tract irritation) Maycause respiratory irritation
Classification not possible
Classification not possible
Section 2 and 11 of SDS issued by ResonacCorporation• GHS (Globally Harmonized System of Classification and Labelling of Chemicals): A system that classifies chemicals
according to the type and degree of hazards, labels the information, and provides safety data sheets according to
globally harmonized rules.
• Not applicable: Since the priority of physical state, chemical structure, chemical property, and hazard items used in
the GHS classification procedures does not fall under the category, it is not subject to the classification for thecategory.
• Not classified: Sufficient information has been obtained to implement the GHS classification, and as a result of theclassification, it does not fall under any of the hazard categories specified in the GHS.
• Classification not possible : There is not enough information for GHS classification, and classification is not possible.

7. ENVIRONMENTAL EFFECTS
Effect assessment
Hazardous to the aquatic environment, short-Results （GHS Hazard Classification）
Not classified
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term (acute)Hazardous to the aquatic environment, longterm (chronic)
Hazardous to the ozone layer
Sources/references

Not classified
Classification not possible
Sections 2 and 12 of the SDS issued byResonac Corporation

Environmental fate/dynamics
Koc=5.6
Mobility in soil
Persistence/degradabili
Biodegradation test (2 weeks): Readily biodegradablety
Bioaccumulation
BCF=3.2
potential
Bioaccumulation potential is presumed to be low.
Conclusion about
The criteria for persistent bioaccumulative and toxic (PBT; remaining
PBT/vPvB
persistently in the environment and possessing high bioaccumulation
potential and toxicity) and very persistent and very bioaccumulative(vPvB; remaining very persistently in the environment and possessing
very high bioaccumulation potential) chemicals are believed toinapplicable.
Sources/references
Sections 12 of the SDS issued by Resonac Corporation

8. EXPOSURE
DetalsOccupational exposures

Consumer exposures

Environmentalexposures

Exposure potentials through main uses
Although our company products are manufactured in closed, wellcontrolled, continuous processes, there is a potential for dermal orinhalation exposure in blending/mixing operation in batches withsignificant contact opportunities in the formulation or manufacture ofarticles (PROC5).
In operations for industrial sprays, such as paints, organic cleaners,
and bonding agent, aerosol generation is expected and could lead todermal and inhalation exposure (PROC7).
There is a potential for dermal or inhalation exposure in operators
during the transfer of substances or preparations from a ship or largecapacity container in the dedicated facility, in association withdust/vapor/aerosol generation, spillage, cleaning of the equipment, etc.
(PROC 8b).
It is used in roller or brushing operation for coating, surface cleaning,
etc. and may cause dermal or inhalation exposure due to thegeneration of steam, droplets, and splashes, wiping operation,
application surface operation, etc. (PROC10).
This product is rarely used directly by general consumers, but it issometimes used as a mixture product, such as a bonding agent and asealing agent, etc. In that case, there is a potential for dermal andinhalation exposure in consumers (PC1).
They may also be used as products, such as paint, solvent, or remover,which may cause dermal or inhalation exposure (PC9a).
Since the products are typically manufactured and used in closed
processes, their emission to the environment is limited. The material isa liquid with a high vapor pressure, and it may be released from its
compounding process mainly into the atmospheric and water
environment (ERC2).
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Precautions

If there is a possibility of exposure in other uses, take appropriate
measures with reference to recommended risk management measures.

9. RISK MANAGEMENT RECOMMENDATIONS
Recommended risk management measures can minimize risks to workers, consumers, and theenvironment from Section 8 exposure scenarios.
DetalsWorkerConsumer
Enviaronment

Special notes(emergency measuresin case of leakage, etc.)

Risk management recommendations
Technical measures
Handle with protective equipment. Use explosion-proof electrical,ventilation, and lighting equipment. Take action to prevent static
discharge, which is an ignition source. Install facilities for eye and bodywashing near the handling place.
Local exhaust and general ventilation
Handle the product in a generally well-ventilated room. Use a local
exhaust ventilation for operations in which the product may come into
contact with the skin, such as the hands.
Permissible concentration
For this product, the control concentration and permissible
concentration of 200 ppm (720 mg/m3) by the Japan Society for
Occupational Health has been published, and the time-weighted
average (TLV-TWA) of 400 ppm has been published by the American
Conference of Governmental Industrial Hygienists (ACGIH). Manageand control the concentration below these values.
Protective equipment
During operation, wear respiratory protection (a certified gas mask fororganic gas [with a collection rate of 95% or higher]) and chemicallyresistant rubber gloves (APF20 [with a protection rate of 95%]) toavoid contact with the skin, and use safety eye protection to avoid
eye irritation. In addition, wear chemical goggles or face protection andchemically resistant protective clothing, apron, and boots, dependingon the usage condition.
Precautions
The operation manager should educate operators about the selectionof appropriate protective equipment, proper usage method, and control
method of the work site.
Use the product according to the product’s instruction manual.
Install appropriate wastewater treatment facilities and exhaust gastreatment facilities. In addition, take measures to prevent leakage, andpay attention to periodic confirmation of discharge volume, daily
control, and handling.
Precautions to human body, protective equipment, and emergency
measures:
Wear appropriate protective equipment during operation to prevent
inhalation, eye or face contact, and skin adhesion. In case of a massive
leakage, immediately evacuate the surrounding personnel and ventilate
the area. Prohibit unauthorized persons from entering the area whereleakage occurred by using a rope to secure the area. Immediately
remove ignition sources from the vicinity, and prepare suitable
extinguishing media (carbon dioxide [CO2], foam, water spray, andpowder).
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Environmental precautions
Take care not to discharge the leaked product into rivers, etc., andaffect the environment.
Precautions

For normal handling, emergency response, disposal, and transportation
control measures, refer to sections 4, 5, 6, 7, 8, 13, and 14 of the SDS
issued by Resonac Corporation.

10. STATE AGENCY REVIEW
Hazard assessment
Situations of review
International Chemical Safety International Chemical Safety CardICSC: 0367
Cards
https://www.ilo.org/dyn/icsc/showcard.display?p_lang=en&p_ca
rd_id=0367&p_version=2
OECD HPVHigh production volume chemical testing programme
https://hpvchemicals.oecd.org/UI/Search.aspx

NITE-CHRIP （ NITE Chemical https://www.nite.go.jp/en/chem/chrip/chrip_search/srhInput
Risk Information Platform）
GHS Classification Results by https://www.nite.go.jp/chem/english/ghs/19-mhlw-2086e.html
the Japanese Government

11. REGULATORY INFORMATION／GHS CLASSIFICATION AND LABELLING INFORMATION
Regulatory information only in Japan
Applicable laws
Regulatory situations
Industrial Safety andSecond-class organic solvents, etc., (Attached Table 6-2 of theHealth Act
Enforcement Order and Article 1, Paragraph 1, Item 4 of theOrdinance on Prevention of Organic Solvent Poisoning)
Working environment assessment standard (Article 65-2,Paragraph 1 of the Act)
Dangerous or Harmful Substances Subject to Be Indicated theirNames（Article 57 Paragraph (1) of the Act, Article 18 item(ⅰ)
and item(ⅱ) appended Table No. 9 of the Enforcement Order）
Dangerous Substances：flammable substances（appended table1
item 4 of Enforcement Order）
Dangerous Articles and Harmful Substances Whose Names, etc.
Should Be Notified（Article 57-2 of the Act, Article 18-2 item(ⅰ)
and item(ⅱ) appended Table No. 9 of the Enforcement Order）
Ethyl acetate（Cabinet Order Number : 177）
Substances on Special medical examination, Current handlingworkers (Article 66, Paragraph 2 of the Act, Article 22, Paragraph
1 of the Enforcement Order)
Poisonous and Deleterious
Substances Control Act

Deleterious Substances（Cabinet Order for the Designation of the
Poisonous and Deleterious Substances, Article 2）

Water Pollution Prevention
Act

Designated Substances（Article 2, Paragraph 4 of the Act, Article
3-3 of the Enforcement Order）

Fire Service Act

Category IV inflammable liquids, Class Ⅰ petroleum, non-watersoluble liquids (Article 2, Paragraph 7 of the Act, Hazardous
Substances, Annexed Table 1, Class 4)
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Offensive Odor Control Act

Specified offensive odor substance (Article 1 of the EnforcementOrder)

Air Pollution Control Act

Volatile organic compound (Article 2 paragraph 4 of the Act)
（Notice from Ministry of the Environment to prefectures）

Act on Prevention of Marine
Pollution and MaritimeDisaster

Hazardous materials (Enforcement Ordinance Appended Table 14)
Hazardous liquid substances (Class Z substances) (AppendedTable 1 of the Enforcement Ordinance)
Appended Table 2 of Cabinet Order on Export Trade Control（Approval of Exports）
Import Trade Control Order Article 4, Paragraph 1, Item 2,Approved Import Item（item 2-2 Approval）

Foreign Exchange andForeign Trade Act

Ship Safety Act

Civil Aeronautics Act

Port Regulations Act

Road ActAct on Control of Export,
Import and Others ofSpecified Hazardous Wastes
and Other Wastes（BaselLaw）

Flammable liquids（Article 3 of Regulations for the Carriage andStorage of Dangerous Goods in Ship, Cabinet Order Concerning theControl of Hazardous Materials appended Table 1）
Flammable liquid（Article 194 of the Enforcement Ordinance,Cabinet Order Concerning the Control of Hazardous Materials
appended Table 1）
Hazardous materials（inflammable liquids） (Article 21-2 of theAct, Article 12 of Enforcement Ordinance, Notification of theEnforcement Regulations of the Port Regulations Act specifying
the types of hazardous materials)
Restrictions on vehicle traffic（Article 19-13 of the Enforcement
Ordinance, Appended Table 2 of Notification No.12 of Japan
Expressway Holding and Debt Repayment Agency）
Hazardous substances contained in waste（Article 2 paragraph 1
item 1-a of the Act, June 18, 2018 Ordinance of the Ministry ofthe Environment No. 12）

Act on Confirmation, etc. of
Release Amounts of SpecificChemical Substances in theEnvironment and Promotionof Improvements to theManagement Thereof ( Law
concerning Pollutant
Release and Transfer
Register / PRTR)

Not applicable

Labor Standards Act

Occupational disease chemicals (Article 75, paragraph 2 of the Act,
Enforcement Ordinance Article 35, Appended Table 1-2, Item (4)1)
3
UN1173 ETHYL ACETATE

UN classification
UN No.
Hazards
Physical hazards
Health hazards

Classification results (hazard information)
Flammable liquids, Category 2
Acute toxicity (inhalation:vapour) Category 4
Serious eye damage/eye irritation, Category 2B
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Specific target organ toxicity (single exposure) Category 3, Narcosis
Specific target organ toxicity (single exposure) Category 3,
Respiratory tract irritation
Labelling Information
Hazard pictograms (GHS)

Signal word (GHS)
Hazard statements (GHS)

DangerHighly flammable liquid and vapour. (H225)
Causes eye irritation (H320)
Harmful if inhaled. (H332)
May cause respiratory irritation. (H335)
May cause drowsiness or dizziness. (H336)

12. CONTACT INFORMATION
CompanyAddress
Departments
Tel. / Fax

Resonac Corporation
1-9-2, Marunouchi, Chiyoda-ku, Tokyo 100-6606 Japan
Olefins & Derivatives Business Unit Organic Chemicals Department+81-3-5470-3492/ +81-3-5533-7922

13. DATE OF ISSUE / REVISION, ADDITIONAL INFORMATION
Date of issue: December 27, 2022
Revisions:
Date of revision
Revised sectionDecember 27, 2022 6, 13
January 1, 2023
3, 6, 7, 10-13

Revised item
VersionUpdate to the latest information Rev.2
Update to the latest information Rev.3

The contents are based on the safety data sheet (SDS) created on January 1, 2023.
Special instructions:
Corporate name and head office address of the seller of a poisonous or deleterious substanceResonac Corporation 1-13-9 Shiba Daimon, Minato-ku, Tokyo

14. DISCLAIMER
The safety summary is part of the effort for the voluntary management of chemical substance inthe chemical industry (GPS/JIPS: Japan Initiative of Product Stewardship). The purpose of thesafety summary is to provide information on the safe handling of the product as an overview andnot to provide professional information, such as the risk evaluation process and its impact onhuman health and the environment. This document is not meant to serve as an alternative to risk
evaluation, such as a Safety Data Sheet (SDS) or a Chemical Safety Report (CSR). This safetysummary is being written as accurately as possible based on data such as laws, materials, andinformation available at the time of publication, but it does not include all data. It does notguarantee anything.

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