Product Safety Summary for Hexanediol
SUBSTANCE NAME
Hexanediol
Hexane-1,6-diol
Hexan-1,6-diol
1,6-Hexanediol
1,6-Hexanediol (8CI, 9CI)
1.6-Hexandiol
1,6- Dihydroxyhexane
Hexamethyleneglycol
Hexamethylenediol
omega.-Hexanediol
alpha.,.omega.-Hexanediol

GENERAL STATEMENT
Hexanediol is a white solid with characteristic odour. It is neither hazardous for human health nor for theenvironment. Hexanediol has a wide range of applications. It has two functional groups which are useful inthe production of various polymers and plastic products. But it also finds application in other chemicalprocesses and is contained in different consumer products.

CHEMICAL IDENTITYEC Name:
EC-No. :CAS-No. :Molecular formula:
Structural formula:hexane-1,6-diol
211-074-0
629-11-8
C6H14O2

USES AND APPLICATIONSHexanediol is obtained after treatment of the mixture of products resulting from the oxidation of cyclohexanewith air. Hexanediol is used to produce materials made of polyester or polyurethane, as monomer for themanufacture of polyesterpolyols, polycarbonatedioles and acrylic monomers, for the production of moleculesthat act as reactive diluents, for the production of halogenated substances and for the production ofadhesives, putties and sealing compounds, cleaners and auxiliary agents. Hexanediol is also used in theprocesses to produce hydrogen, hydrogen peroxide, sodium perborate and peroxyacetic acid and as anintermediate for pharmaceutical products. It is used as an ingredient for the production of polymeric
thickeners, plasticizers for polyvinyl chloride, sizing agents, surfactants, for starches and chemically modified
starch for application in the paper, textile and food industry and for personal hygiene products like shampoo,creams, as well as for paints.

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Product Safety Summary for Hexanediol
PHYSICAL CHEMICAL PROPERTIESHexanediol is a white solid at room temperature. It has a characteristic odor.
Melting point/range:
Boiling point/boiling range:
Decomposition temperature:
Flashpoint:
Flammability (solid, gaseous):
Selfignition temperature:
Explosion limits:
Lower:
Upper:
Explosive properties:
Molecular weight:
pH value:log Pow:
Vapor pressure:
Vapor density:
Relative density:
Solubility in/Miscibility
with water:
Oxidizing properties:

39.5 – 42.1 °C
250 °C at 1013 hPa
Not determined
136 °C
Combustible, but not highly flammable solid
320 °C6.6 %16 %Non explosive.
118.1742 g/mol
7.6 at 20 °C and 500 g/l
0 (at 25 °C)
0.000666 hPa at 25 °C
Not determined
0.96 g/cm3 at 20 °CMiscible
No oxidizing properties

HEALTH EFFECTS
Hexanediol has no marked health hazard properties. Its acute toxicity is very low via all tested routes ofexposure (oral, skin and inhalation). It has no irritation or sensitization effects. Repeated dose and long termhealth or reproductive effects could not be established either. Its physical properties give no rise to concern.
The flammability of hexanediol is low. Therefore, Hexanediol has a very low overall human health hazard
potential.
EFFECT ASSESSMENT
Acute Toxicity(oral/dermal/inhalation)
Irritation/Corrosivity(skin/eye/respiratory tract)
Sensitization(skin/respiratory tract)
Repeated Dose Exposure

Mutagenicity
Carcinogenicity
Reproductive Toxicity

April 10th, 2012RESULT
Hexanediol is of low acute toxicity via all routes of exposure.
Hexanediol is not irritating to the skin or to the eyes. Corrosivity
was not tested on the basis of the absence of irritation properties.
Based on the available data Hexanediol is not considered to haveskin or respiratory sensitization properties.
Oral repeated dose test results with Hexanediol suggest that nomarked toxicity should be expected. Dermal and inhalation
repeated dose exposure testing is considered unnecessary basedon expected exposure routes and the result of the oral repeateddose test.
All available in vitro test data indicates that Hexanediol does notcause mutagenic effects.
No carcinogenicity data has been generated due to the negative
mutagenicity results.
Screening test information indicates that Hexanediol has noadverse reprotoxicity effects.

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Product Safety Summary for Hexanediol
ENVIRONMENTAL EFFECTS
The results of all acute aquatic studies on fish, algae, plants and invertebrates indicate a low environmental
acute hazard potential for Hexanediol. Hexanediol is readily biodegradable and it has a very low
bioaccumulation potential. Considering all available data on biotic and abiotic degradation, bioaccumulationand toxicity, it can be stated that the substance is neither persistent nor toxic to the environment and that it
will not bio-accumulate. Overall, Hexanediol has a very low environmental hazard potential.
EFFECT ASSESSMENT
Aquatic Toxicity

RESULTFish, daphnia, algae and plant studies indicate that the aquatic
toxicity of Hexanediol is low.

FATE AND BEHAVIOR
Biodegradation
Bioaccumulation potential

RESULT
Hexanediol is readily biodegradable.
Hexanediol will preferentially distribute to water. Based on the low
partition coefficient it is concluded that bioaccumulation is notexpected.
Based on its low toxicity, bioaccumulation potential and readybiodegradability, Hexanediol does not meet the criteria for PBT orvPvB.

PBT/vPvB conclusion

EXPOSURE
Human Health
Hexanediol is used in many different applications. In industrial sites, it is used for the production of hydrogen,hydrogen peroxide, sodium perborate and peroxyacetic acid. But its main industrial use is as monomer orreactant; therefore, Hexanediol will no longer be present as such in downstream products, practicallyeliminating the exposure potential for professional users and consumers.
On the other hand, Hexanediol is contained in formulated products of usual use, such as adhesives, putties,
sealing compounds, cleaners, paints and inks, synthetic resins and personal hygiene products (shampoo,creams, etc.). In all previous cases, Hexanediol occurs in diluted form, so professionals and consumers
exposure level will be very low.
Environment
Hexanediol is solid at room temperature and it has low volatility in liquid form above its boiling point.
Therefore, the probability of release in pure form to any of the environmental compartments is low, undernormal industrial use conditions. There may be some release to waste water streams as a result of normal use
or industrial cleaning operations. Due to its readily biodegradability, Hexanediol should not cause further
environmental exposure.

RISK MANAGEMENT RECOMMENDATIONSHexanediol poses very low human health and environmental risks. However it is a good practice to train
personnel handling the substance and to protect workers who may be exposed to Hexanediol by taking theusual precautionary measures to protect against chemical exposure. Therefore, protective clothing, gloves
and safety glasses with side shields should be worn when handling Hexanediol. Good ventilation is requiredin areas where Hexanediol is handled. Respiratory protection is not required unless Hexanediol is released in
the form of gas or in the form of aerosols. Hexanediol is not flammable; however, it is good practice to preventthe build-up of electrostatic charge when storing it.

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Product Safety Summary for Hexanediol
For environmental protection in case of accidental release: do not allow product to reach sewage system or
any water course. Retain and dispose of contaminated wash water.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
Hexanediol is included in the OECD list of High Production Volume (HPV) chemicals.
Hexanediol is listed in the following Chemical Inventories:_ TSCA, EINECS, ENCS, AICS, Canadian DSL, KECI,PICCS, IECSC, and NZIoC.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Not classified.
Labeling according to REGULATION (EC) No 1272/2008:
Pictogram: none
Signal word: none
Hazard statements: none

CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company:
Department:
Address:
Town/Country:
Postal code:
E-mail:UBE Chemical Europe, S.A
Corporate Social Responsibility
Poligono Industrial El Serrallo, s/nGrao de Castellon (Castellon), Spain
12100
sds.ube.eu@ube.es

Additional information can be found at:
http://www.ube.es
http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/

GLOSSARY
Acute toxicity
AICSBiodegradation
Bioaccumulation
Canadian DSL
Carcinogenicity
CASApril 10th, 2012

Harmful effect resulting from a single or shortterm exposure to a substance.
Australian Inventory of Chemical Substances.
Decomposition or breakdown of a substance undernatural conditions (actions of micro-organisms
etc).
Progressive accumulation in living organisms of achemical substance present in the environment.
Domestic Substances List of Canada.
Substance effects causing cancer.
Chemical Abstracts Service (division of theAmerican Chemical Society).

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Product Safety Summary for Hexanediol
Chronic toxicity
EINECSENCSFlash point
Genotoxicity
GHS
HPV
Hydrolyze
IECSC
Intermediate
KECI
Monomer

Mutagenicity
NZIoC
PBT
Persistence
PICCS
Risk Management Measures

REACH (EC) No. 1907/2006
REGULATION (EC) No 1272/2008
Reprotoxicity
Sensitizing
Sediment
TSCA
Vapor pressure
vPvB

April 10th, 2012

Harmful effect after repeated exposures or longterm exposure to a substance.
European Inventory of Existing Commercial
Chemical Substances
Existing Notified Chemical Substances (Japan).
The lowest temperature at which vapor of thesubstance may form an ignitable mixture with air.
Substance effect that causes damage to genes,
including mutagenicity and clastogenicity.
Globally Harmonized System of Classification andLabeling of Chemicals
High Production Volume Chemicals.
Undergo hydrolysis; decompose by reacting withwater.
Inventory of Existing Chemical Substances
Produced or Imported in China.
Substance that is manufactured for and consumed
in or used for chemical processing in order to betransformed into another substance.
Korean Existing Chemical Inventory.
Means a substance which is capable of forming
covalent bonds with a sequence of additional likeor unlike molecules under the conditions of therelevant polymer-forming reaction used for theparticular process.
Substance effect that cause mutation on genes.
New Zealand Inventory of Chemicals
Persistent, bioaccumulative, toxic chemical.
Refers to the length of time a compound stays in
the environment, once introduced.
Philippine Inventory of Chemicals and Chemical
Substances.
Engineering controls, conditions and protective
equipment needed to be implemented to ensurethat the risks to human health and theenvironment are adequately controlled.
European Commission Regulation concerning theRegistration, Evaluation, Authorization andRestriction of Chemicals.
European Commission Regulation onClassification, Labeling and Packaging ofSubstances and Mixtures.
Including teratogenicity, embryotoxicity andharmful effects on fertility.
Allergenic.
Topsoil, sand and minerals washed from land into
water forming in the end a layer at the bottom ofrivers and sea.
Toxic Substance Control Act (USA).
A measure of a substance’s property to evaporate.
Very persistent, very bio-accumulative.

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Product Safety Summary for Hexanediol
DATE OF ISSUE
April 2012

REVISION
Version 1.0

DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information isprovided in utmost good faith and has been based on the best information currently available, is to berelied upon at the user’s own risk. No representations or warranties are made with regards to its
completeness or accuracy and no liability will be accepted by UBE Chemical Europe, S.A for damages of
any nature whatsoever resulting from the use of or reliance on the information.

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