Product Safety Summary for Cyclohexanone
SUBSTANCE NAME
Cyclohexanone
Cyclohexanon
Cyclohexanone (7CI, 8CI, 9CI)
AnonAnone
Pimelin ketone
Pimelic ketone

GENERAL STATEMENT
Cyclohexanone is a light yellow liquid with an odor that resembles peppermint oil. It is an organic compoundthat is mainly used as a chemical intermediate for the production of monomers and as a solvent in a range offormulated products for use by professional users and consumers. In general, the health hazards are low, but
protection against inhalation, skin and eye contact is required. Cyclohexanone is a flammable liquid and it canbe regarded as non-hazardous to the environment.

CHEMICAL IDENTITYEC Name:
EC-No. :CAS-No. :Molecular formula:
Structural formula:cyclohexanone203-631-1
108-94-1
C6H10OUSES AND APPLICATIONS
Cyclohexanone is a light yellow liquid. It is produced by the oxidation of cyclohexane and subsequent
treatment of the reaction product. Cyclohexanone is mainly used as an intermediate to produce monomers,
particularly for the production of well-known plastics like polyamide. In industrial use, it is also commonlyused as intermediate for the manufacturing of fine chemicals. Furthermore it finds application as a laboratory
reagent and as a solvent in a wide variety of formulated products, including products for professional usesand consumer products. It is used in formulated products like adhesives, coatings, paints, printing inks andbiocidal and plant protection products.

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Product Safety Summary for Cyclohexanone
PHYSICAL CHEMICAL PROPERTIES
Cyclohexanone is a light yellow liquid at room temperature and pressure, with a smell like peppermint oil.
Melting /freezing point:
Boiling point/boiling range:
Decomposition temperature:
Flashpoint:
Flammability (solid, gaseous):
Ignition temperature:
Explosion limits:
Lower:
Upper:
Explosive properties:
Molecular weight:
pH value:log Pow:
Vapor pressure:
Vapor density:
Relative density:
Dissociation constant:Solubility in/Miscibility
with water:
Dynamic viscosity:
Oxidising properties:-31 °C at atmospheric pressure
154.3 °C at 1013.25 hPa
Not determined
44 °C (closed cup
Flammable upon ignition
420 °C at 1013 at hPa
1.05 vol % (air)
9.9 vol % (air)Not explosive.
98.143
6.6 at 20 °C
0.86 at 25 °C
7 hPa at 30 °C
Not determined
0.9465 g/cm3 at 20 °C
Not applicable86 g/l at 20 °C
2.2 mPa.s at 25 °C
No oxidizing properties

HEALTH EFFECTS
Cyclohexanone is moderately hazardous for human health. The acute toxicity via oral and dermal exposure isproved to be low. However, inhalation exposure studies showed some adverse acute effects, sufficient enoughto classify it as hazardous. Also irritation and corrosivity studies showed adverse effects on the skin and inthe eyes. On the other hand, the results of oral repeated dose testing give no rise to concern. Mutagenicity
tests, in vitro and in vivo, were negative as well as carcinogenicity, fertility and reproductive toxicity studies.
Cyclohexanone is a flammable liquid and care needs to be taken to avoid the risks of this inherent hazard
property when handling Cyclohexanone in pure form or in high concentrations.
EFFECT ASSESSMENT
Acute Toxicity(oral/dermal/inhalation)
Irritation/Corrosivity(skin/eye/respiratory tract)
Sensitization(skin/respiratory tract)
Repeated Dose Exposure
Mutagenicity
Carcinogenicity
Reproductive Toxicity

April 19th, 2012RESULT
Cyclohexanone has a low acute toxicity for oral and dermal
exposure but inhalation exposure studies suggest that it needs tobe considered harmful for that exposure route.
Cyclohexanone is irritating and corrosive to the skin and to theeyes.
Based on the available data, Cyclohexanone is not considered tohave skin or respiratory sensitization properties.
Test results with oral and intravenous exposure indicate that there
is no marked repeated dose toxicity.
All available test data indicates that Cyclohexanone does not cause
mutagenic effects.
Oral carcinogenicity study data suggests that Cyclohexanone is notcarcinogenic.
All available data suggest that Cyclohexanone has no adverse
fertility or reproductive effects.

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Product Safety Summary for Cyclohexanone
ENVIRONMENTAL EFFECTS
Based on the values of the octanol water partition coefficient and Henry’s constant, Cyclohexanone
distributes mainly into water and air. Cyclohexanone’s toxicity to aquatic species is low. It is also readily
biodegradable and has a low bioaccumulation potential. Also, since the overall toxicity of cyclohexanone islow, it can be concluded that it is not hazardous to the environment or to humans through environmental
exposure.
EFFECT ASSESSMENT
Aquatic Toxicity

RESULT
Studies indicate that Cyclohexanone is not toxic to fish and todaphnia and has a low toxicity to algae and aquatic plants.

FATE AND BEHAVIOR
Biodegradation

RESULT
Cyclohexanone is readily biodegradable in water. Biodegradability
in soil and sediment is not relevant.
Basing on its logPow value, significant accumulation ofCyclohexanone in organisms is not expected.
Regarding all available data on biotic and abiotic degradation,
bioaccumulation and toxicity, it can be stated that the substancedoes not fulfill the PBT criteria nor the vPvB criteria.

Bioaccumulation potential

PBT/vPvB conclusion

EXPOSURE
Human Health
Exposure can occur to workers in industrial facilities where Cyclohexanone is produced, stored, handled orprocessed. Professional users or consumers may come into contact with Cyclohexanone through commonlyused formulated products, such as adhesives, coatings, paints, printing inks and biocidal and plant protection
products. Based on the physical properties of Cyclohexanone skin contact and inhalation are the most likely
routes of exposure. Consumer applications are such that consumer exposure will typically be infrequent, forbrief periods or in small quantities. Therefore the use of Cyclohexanone by the consumer is not considered topose a health risk. However, the level of exposure to professional and industrial users may be such that risk
management measures must be taken.
Environment
The probability of release of Cyclohexanone in concentrated form to any of the environmental compartments
is low under normal industrial use conditions. Also the environmental release of Cyclohexanone fromformulated products will be insignificant under normal use conditions. Cyclohexanone is readily
biodegradable; therefore, accidental release of small quantities to waste water or surface water should notcause further environmental exposure.

RISK MANAGEMENT RECOMMENDATIONS
Cyclohexanone poses some risks that need to be managed. Exposure via inhalation, skin and eye contact must
be avoided, specifically by industrial users and certain professional users. The exposure levels of consumers
are low; therefore, typical consumer uses do not require specific risk management measures.
Personnel handling the substance need to be trained in the safe use of Cyclohexanone and workers who may
be exposed to it need to be protected by taking adequate measures to protect against chemical exposure.
Respiratory protection devices with organic gas filters must be worn, as well as protective clothing, gloves
and tightly fitting safety goggles.

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Product Safety Summary for Cyclohexanone
Also the flammability of Cyclohexanone poses risks that need to be carefully managed, so risk management
needs to focus also on fire prevention. Workers should be properly informed about the risks and trained in
the prevention and protection measures to be adopted. Containers and equipment containing Cyclohexanone
should be correctly labeled clearly indicating its flammability hazard. Operations involving the possible
release of liquid or vapor should be carried out using closed processes or, failing this, in well-ventilated areas
or in installations with local extraction systems. The creation and accumulation of static discharge duringtransfer of the substance should be controlled by precautionary measures such as grounding and bonding
containers and equipment. For environmental protection in case of accidental release: do not allow productto reach sewage system or any water course. Retain and dispose of contaminated wash water.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
Cyclohexanone is included in the OECD list of High Production Volume (HPV) chemicals.
Cyclohexanone is listed in the following Chemical Inventories: AICS, ENCS, EINECS, NZIoC, DSL Canada,IECSC, KECI, TSCA, PICCS.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Flammable liquid:
Acute toxicity:
Acute toxicity:
Acute toxicity:
Skin/Eye(Corrosion/irritation):

Flammable liquid Category 3; H226 Flammable liquid and vapour.
Category 4; Oral; H302 Harmful if swallowed.
Category 4; Dermal; H312 Harmful in contact with skin.
Category 4; Inhalation; H332 Harmful if inhaled.
Skin Irritation Category 2; H315 Causes skin irritation.
Eye Damage Category 1; H318 Causes serious eye damage.

Labeling according to REGULATION (EC) No 1272/2008:
Pictogram:

Signal word: Danger
Hazard statements:

April 19th, 2012

H226: Flammable liquid and vapour.
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H332: Harmful if inhaled.
H315: Causes skin irritation.
H318: Causes serious eye damage.

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Product Safety Summary for Cyclohexanone
CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company:
Department:
Address:
Town/Country:
Postal code:
E-mail:UBE Chemical Europe, S.A
Corporate Social Responsibility
Poligono Industrial El Serrallo, s/nGrao de Castellon (Castellon), Spain
12100
sds.ube.eu@ube.es

Additional information can be found at:
http://www.ube.es
http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/

GLOSSARY
Acute toxicity
AICS
Biodegradation
Bioaccumulation
Canadian DSL
Carcinogenicity
CAS
Chronic toxicity
EINECS
ENCS
Flash point
Genotoxicity
GHS
HPV
Hydrolyze
IECSC
Intermediate
KECI

April 19th, 2012

Harmful effect resulting from a single or shortterm exposure to a substance.
Australian Inventory of Chemical Substances.
Decomposition or breakdown of a substance undernatural conditions (actions of micro-organisms
etc).
Progressive accumulation in living organisms of achemical substance present in the environment.
Domestic Substances List of Canada.
Substance effects causing cancer.
Chemical Abstracts Service (division of theAmerican Chemical Society).
Harmful effect after repeated exposures or longterm exposure to a substance.
European Inventory of Existing Commercial
Chemical Substances
Existing Notified Chemical Substances (Japan).
The lowest temperature at which vapor of thesubstance may form an ignitable mixture with air.
Substance effect that causes damage to genes,
including mutagenicity and clastogenicity.
Globally Harmonized System of Classification andLabeling of Chemicals
High Production Volume Chemicals.
Undergo hydrolysis; decompose by reacting withwater.
Inventory of Existing Chemical Substances
Produced or Imported in China.
Substance that is manufactured for and consumed
in or used for chemical processing in order to betransformed into another substance.
Korean Existing Chemical Inventory.

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Product Safety Summary for Cyclohexanone
Monomer

Mutagenicity
NZIoC
PBT
Persistence
PICCS
Risk Management Measures

REACH (EC) No. 1907/2006
REGULATION (EC) No 1272/2008
Reprotoxicity
Sensitizing
Sediment
TSCA
Vapor pressurevPvB

Means a substance which is capable of forming
covalent bonds with a sequence of additional likeor unlike molecules under the conditions of therelevant polymer-forming reaction used for theparticular process.
Substance effect that cause mutation on genes.
New Zealand Inventory of Chemicals
Persistent, bioaccumulative, toxic chemical.
Refers to the length of time a compound stays in
the environment, once introduced.
Philippine Inventory of Chemicals and ChemicalSubstances.
Engineering controls, conditions and protective
equipment needed to be implemented to ensurethat the risks to human health and theenvironment are adequately controlled.
European Commission Regulation concerning theRegistration, Evaluation, Authorization andRestriction of Chemicals.
European Commission Regulation onClassification, Labeling and Packaging of
Substances and Mixtures.
Including teratogenicity, embryotoxicity andharmful effects on fertility.
Allergenic.
Topsoil, sand and minerals washed from land into
water forming in the end a layer at the bottom ofrivers and sea.
Toxic Substance Control Act (USA).
A measure of a substance’s property to evaporate.
Very persistent, very bio-accumulative.

DATE OF ISSUE
April 2012

REVISION
Version 1.0

DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information isprovided in utmost good faith and has been based on the best information currently available, is to berelied upon at the user’s own risk. No representations or warranties are made with regards to its
completeness or accuracy and no liability will be accepted by UBE Chemical Europe, S.A for damages of
any nature whatsoever resulting from the use of or reliance on the information.

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