GPS Safety Summary Reference No.: JIPS_MSP_IC‐1041

SHOWA DENKO K.K.

GPS/JIPS Safety Summary
1. SUBSTANCE NAME
Glycine(CAS No.: 56-40-6)

2. GENERAL STATEMENT

Glycine is one of the amino acids regarded as non-essential for humans that constitute a
lot of proteins in nature. In general, it is included in many animal proteins. In particular,
it contains a lot to extract, such as in sea urchins and shellfish shrimp and crab, it is themain resource of good taste.
3. CHEMICAL IDENTITY
Item
Chemical or genericname
Product name
CAS No.
Other Nos.
Chemical formula
Structural formula
Sources/references

Description
Aminoacetic acid
Glycine ( Aminoacetic acid )56-40-6
Japan: Chemical Substances Control Law (9)-77
EC No./EINECS No.: 200-272-2
H2NCH2COOH
H2N-CH2-COOH
Sections 3 and 16 of the SDS issued by SHOWA DENKO K.K.

4. USES AND APPLICATIONS
Main uses

The substance is used as a food additive, feed additive, and as asource material for cosmetic products, pharmaceutical agent andamino acid synthesis.In particular, it is used as an additive inany food for long shelf life and flavor enhancer component inbrewing, meat processing, beverages, seasonings industry.Inaddition, it is used in the plating reagent such as industrial.

5. PHYSICAL/CHEMICAL PROPERTIES
Under normal temperatures, glycine is a odorless and white powder.
Appearance
Color
Odor
Relative density

Crystal or Crystalline powder
WhiteOdorless
1.57

GPS Safety Summary Reference No.: JIPS_MSP_IC‐1041

Melting point
Burning quality
Lowerandupper
Flammability limits
Auto-ignition
temperature
Molecular weight
Vapor pressure
Solubility in water
Partition coefficient(n-octanol/water)
Others
Sources/references

182 / 233-290 ºC(Decomposition)
No reliable data available.
No reliable data available.
No reliable data available.
75.05 g/mol
1.28×10-7 mmHg (25 ºC)
250 g/L (25 ºC)
LogPow: -3.2
Minimum-ignition energy: 3600mJ
Section 9 of the SDS issued by SHOWA DENKO K.K.

6. HEALTH EFFECTS
Effect assessment
Acute toxicity (oral)
Acute toxicity (dermal)
Acute toxicity (inhalation; gases)
Acute toxicity (inhalation; vapor)
Acute toxicity (inhalation; dust/mist)
Skin corrosion/irritation
Serious eye damage/eye irritation
Respiratory sensitization
Skin sensitization
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
Specific target organ toxicity (single exposure)Specific target organ toxicity (repeatedexposure)
Aspiration hazard
Sources/references

Results (GHS(Note 1) hazard classification)
Not classified (Note 2)Classification not possible (Note 3)
Not applicable (Note 4)Classification not possible
Classification not possible
Classification not possible
Classification not possible
Classification not possible
Classification not possible
Classification not possible
Classification not possible
Classification not possible
Classification not possible
Classification not possible

Classification not possible
Sections 11 of the SDS issued by SHOWADENKO K. K.
(Note 1) GHS (Globally Harmonized System of Classification and Labeling of Chemicals): It
is a system for classifying chemicals according to type and hazard level, and for indicatinglabel information pursuant to the globally unified rules for offering Safety Data Sheets.
(Note 2) Not classified: when the hazards are believed to be less than even the lowest hazard
classification defined in the GHS.
(Note 3) Classification not possible: when unable to classify due to a lack of sufficiently
reliable data for defining the classification.
(Note 4) Not applicable: when chemicals do not fall within the scope of classification because
the physical properties defined in the GHS do not apply.

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GPS Safety Summary Reference No.: JIPS_MSP_IC‐1041

7. ENVIRONMENTAL EFFECTS
Effect assessment

Results (GHS hazard classification)

Hazardous to the aquatic environment
Acute hazard
Long-term hazard
Hazardous to the ozone layer
Sources/references

Environmental
fate/dynamics
Mobility in soil
Persistence/degradability
Bioaccumulation
potentialConclusion about
PBT/vPvB

Sources/references

Not classified
Not classified
Montreal Protocol on Substances that
Deplete the Ozone Layer (revised version):
not included in the list
Sections 12 of the SDS issued by SHOWADENKO K.K.

Results
No reliable data available.
Readily biodegradable in nature.
Bioaccumulation potential is presumed to be low.
The criteria for persistent bioaccumulative and toxic (PBT;remaining persistently in the environment and possessing highbioaccumulation potential and toxicity) and very persistent andvery bioaccumulative (vPvB; remaining very persistently in theenvironment and possessing very high bioaccumulation potential)
chemicals are believed to inapplicable.
Section 12 of the SDS issued by SHOWA DENKO K.K.

8. EXPOSURE

Occupational
exposuresConsumer
exposures

Exposure potentials through main uses
Glycine is used mainly as a food additive, feed additive, and as asource material for pharmaceutical agent and amino acid synthesis.
No harmful influence has been found so far in the generalenvironment, but workers could be exposed through the skin or
inhalation. This could occur when powders of the substance arehandled under normal temperatures, in mixing/blending, measuring,packing, unpacking and other processes. Although no harmful effecthas been reported, irritation to the respiratory tracts could result if
high-density dusts of the substance are inhaled. Moreover, the eyes orskin could also be affected through direct contact. No harmful effects
caused by swallowing have been reported.
(PROC3)
There is a possibility of dermal, inhalation exposure to workers whensuch a device failure, maintenance, sampling and etc., at synthesis in
the closed batch system or preparation work.
(PROC4)In the process and other batch of opportunities for exposure, there isa possibility of dermal, inhalation exposure to workers at the time ofthe device failure maintenance, sampling, filling, and discharge.
Glycine is used mainly as a food additive, feed additive, and as asource material for pharmaceutical agent.
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GPS Safety Summary Reference No.: JIPS_MSP_IC‐1041

There is the potential that consumers could be exposed thoughdermal and inhalation exposure. Although no harmful effects havebeen reported, the substance could irritate respiratory tracts when its
high-density dusts are inhaled, and the eyes and skin could beaffected upon direct contact. No harmful effects caused by swallowing
have been reported.
(PC14)
There is a possibility of dermal exposure to consumers, when it isused as a product of the metal treatment agents such as plating.
Environmentalexposures(ERC1)
It may be released mainly into the aquatic environment and theatmosphere from the manufacturing process of the material in theindustry.
(ERC6a)There is a possibility of release into the aquatic environment and theatmosphere mainly when it will be used as an intermediate for thechemical components in the manufacture of food additives andmaterials preparation of others.
Although environmental exposure is possible, no specificenvironmental effects have been observed as mentioned in Section 7
Environmental Effects.

Precautions

If there is the potential for exposure during use in other applications,please implement appropriate measures by referring to the risk
management recommendations.

9. RISK MANAGEMENT RECOMMENDATIONS

Occupational
exposuresConsumer
exposures

Risk management recommendations
Technical measures; local ventilation; general ventilation
The substance is manufactured mainly in closed processes, butthere is the potential for worker’s exposure during sampling,
analysis, packing and other processes at manufacturing places. It isrequired to manage and control worker’s exposure by installing local
or general ventilation, and a facility for washing the eyes and bodyat places where the substance is used.
Allowable exposure limit
Has not been set.
Protective equipment
While working, wear appropriate protective eyewears, dust-proof
masks, air-supplied respirators, clothes and protective gloves madeof materials impermeable to powders.
Precautions
Managers are asked to provide workers training concerning theselection and use of appropriate protective equipment, worksite
management, etc.
It is believed that end-products, which are commercially distributed,
could not contain powders. However, if they do, take a precaution not toinhale carelessly their dusts and not to be largely exposed to their dusts
on skin.
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GPS Safety Summary Reference No.: JIPS_MSP_IC‐1041

Environmental
exposures
Sources/references

The substance is low in acute toxicity and readily biodegradable.
Additionally, no influence on the environmental life has been reported.
However, avoid discharging it carelessly into the environment.
Sections 6, 7, 8, and 13 of the SDS issued by SHOWA DENKO K.K.

10. STATE AGENCY REVIEW
Hazard assessment
International Chemical
Safety Cards
OECD HPV
REACH

Situations of review
None
None
Intermediate use only
http://apps.echa.europa.eu/registered/data/dossiers/DISS‐
9d843495‐afb9‐39c4‐e044‐00144f67d249/DISS‐
9d843495‐afb9‐39c4‐e044‐00144f67d249_DISS‐
9d843495‐afb9‐39c4‐e044‐00144f67d249.html－Others
Japan Challenge program

http://www.safe.nite.go.jp/jcheck/detail.action?cno=56-40-6&m
no=9-0077&request_locale=ja=en

11. REGULATORY INFORMATION/GHS CLASSIFICATION-LABELING INFORMATION
Regulatory information in Japan
Applicable laws
Regulatory situations
Food Sanitation Act
・Specified Additives, Article 10 of the Act, Article 12
Appended Table 1 of Ordinance for Enforcement (99 glycine)
Feed Safety Act
・Specified Feed Additives, paragraph 3, Article 2 of the Act(aminoacetic acid)
UN No.
None
GHS classification, label information
Hazards
Health hazards
Acute toxicity (oral)
Hazardous to the aquatic environment
Acute hazard
Long-term hazard
GHS label elements
Pictogram or symbol
Signal word
Hazard statement

Classification results (hazard information)
Not classified
Not classified
Not classified
None
None
None

12. CONTACT INFORMATION
Company nameAddress
Department
Telephone, fax

SHOWA DENKO K.K.
Muza Kawasaki Central Tower 23rd floor, 1310 Omiya-cho,Saiwai-ku, Kawasaki, Kanagawa, Japan
Organic Product Group, Ammonia and Derivatives Department,
Basic Chemicals Division+81-44-520-1348/+81-44-520-1349
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GPS Safety Summary Reference No.: JIPS_MSP_IC‐1041

13. DATE OF ISSUE AND REVISION, ADDITIONAL INFORMATION
Date of issue:October 10, 2013
Revisions:
Date of revision
Revisedsection

Revised item

VersionSpecial instructions: None

14. DISCLAIMER
This Safety Summary which is a translation of original Safety Summary prepared inJapanese, has been prepared as a part of the efforts by GPS/JIPS: Japan Initiative of ProductStewardship by the chemical industry. This Safety Summary is meant to provide an outline ofinformation related to the safe handling of the subject substance rather than provide expert
information regarding the risk assessment processes, the effect on human health or theenvironment, etc. Moreover it is not a replacement for the Safety Data Sheet (SDS), theChemical Safety Report (CSR), or other risk assessment documents. To the greatest extent
possible, the Safety Summary contains accurate statements based on laws, materials,
information and other data available at the time of issue. However, it does not cover all suchdata. Additionally, it does not intend to provide a guarantee in any way.

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