Product Safety Summary for 12-Aminododecanoic Acid
SUBSTANCE NAME
12-Aminododecanoic acid
12-Aminolauric Acidomega-Aminolauric acid
ADAGENERAL STATEMENT

12-Aminododecanoic acid is a white solid and almost odorless compound. At 20°C, the relative density is 1.17,
which is higher than that of water, and the vapor pressure is 0.000000001 Pa. 12-Aminododecanoic acid isused in industrial applications as a monomer for the manufacture of polyamide, polymers, thermoplastics,
intermediate in the production of glue. 12-Aminododecanoic acid is also used in the laboratory as a reagent.
12-Aminododecanoic acid is not known to cause remarkable adverse human health or environmental effects,
but after repeated oral ingestion in rats, it showed adverse effects for kidney and hematological and blood
chemical changes. When using 12-Aminododecanoic acid make sure that there is adequate ventilation.
Protective clothing, gloves and safety glasses with side shields should be worn when handling.

General population will not come in contact significantly with this chemical via environment due to theproduction of the substance as 12-Aminododecanoic acid is manufactured in closed processes which also
minimizes exposure potential to workers. No significant exposure to the environment is expected. The
substance is not intended for consumer uses. The usual general precautionary measures to prevent worker
and environmental exposure to chemicals should also be taken when handling 12-Aminododecanoic acid inindustrial uses.

CHEMICAL IDENTITYEC Name:
EC-No. :CAS-No. :Molecular formula:
Structural formula:

12-Aminododecanoic acid211-754-7
693-57-2
C12H25NO2

USES AND APPLICATIONS
12-Aminododecanoic acid is used in many different applications. 12-Aminododecanoic acid is used inindustrial applications as a monomer for the manufacture of polyamide, polymers, thermoplastics,
intermediate in the production of glue. 12-Aminododecanoic acid is also used in the laboratory as a reagent.

PHYSICAL CHEMICAL PROPERTIES

12-Aminododecanoic acid is a white solid and almost odorless compound. At 20°C, the relative density is 1.17,
which is higher than that of water, and the vapor pressure is 0.000000001 Pa. The melting point of thissubstance is 185.7°C and the boiling point 210°C. Since the substance does not react with water or containany groups that might oxidize or spontaneously ignite, it is not expected that 12-Aminododecanoic acidwould be flammable, self-ignite, oxidize or explode at ambient conditions.

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Product Safety Summary for 12-Aminododecanoic Acid
Melting point/range:
185.7 °C at 101.3 kPa.
Boiling point/boiling range:
210 °C at 101.2 kPa.
Decomposition temperature: >210 °C
Flammability (solid, gaseous): non-flammable
Explosive properties:
non-explosive
Auto-ignition temperature:
Not applicable.
Molecular weight:
215.332 g/mol.
Water solubility:
0.137 g/L at 20 °C
logPow:-0.607 at 24.6 °C
Vapor pressure:
0.000000001 Pa at 25°C
Relative density:
1.17 g/cm3 at 20°C
Oxidizing properties:
No oxidizing properties.

HEALTH EFFECTS

12-Aminododecanoic acid has no marked health hazard properties, but after repeated oral ingestion in rats,
12-Aminododecanoic acid showed adverse effects for kidney and hematological and blood chemical changes
in the higher doses tested. Based on available data, 12-Aminododecanoic acid has no relevant acute toxicity ifswallowed or in contact with skin after a one-time exposure. Due to a low vapor pressure, inhalation
exposure is unlikely; therefore, no data is available. 12-Aminododecanoic is not irritating to skin and eyes.
Based on available data the substance is not considered to be a skin sensitizer. Standard tests indicate 12Aminododecanoic acid is not mutagenic nor genotoxic. Available data show no evidence that the substance iscarcinogenic. Based on available data there is no evidence that 12-Aminododecanoic acid is a reproductive ordevelopmental toxin.
EFFECT ASSESSMENT
Acute Toxicity(oral/dermal/inhalation)
Irritation/Corrosivity(skin/eye/respiratory tract)
Sensitization(skin/respiratory tract)
Mutagenicity
Carcinogenicity

Reproductive Toxicity
Repeated Exposure

ENVIRONMENTAL EFFECTSRESULT
12-Aminododecanoic acid is of low acute toxicity via all routes ofexposure.
12-Aminododecanoic acid is not irritating to skin and eyes.
Corrosivity was not tested on the basis of the absence of irritation
properties.
Based on the available data 12-Aminododecanoic acid is notconsidered to have skin or respiratory sensitization properties.
All available in vitro test data indicates that 12-Aminododecanoic
acid does not cause mutagenic effects.
No carcinogenicity data has been generated due to the negative
mutagenicity results.
Screening test information indicates that 12-Aminododecanoic acidhas no adverse reproductive effects.
The oral administration of 12-aminododecanoic acid to rats bygarbage, at dose levels of 0, 50, 250, 1,000 mg/kg/day, resulted intreatment related effects at 250 and 1,000 mg/kg/day. The kidney,hematological and blood chemical changes were considered torepresent an adverse.

The results of all acute aquatic studies on fish, algae, plants and invertebrates indicate that 12Aminododecanoic acid is not toxic to fish and to daphnia and has a low toxicity to algae and aquatic plants.
12-Aminododecanoic acid is readily biodegradable and it has a low bioaccumulation potential. Considering all
available data on biotic and abiotic degradation, bioaccumulation and toxicity, it can be stated that theMarch 31, 2016

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Product Safety Summary for 12-Aminododecanoic Acid
substance is neither persistent nor toxic to the environment and that it will not bio-accumulate. Overall, 12Aminododecanoic acid has a low environmental hazard potential.
EFFECT ASSESSMENT
Aquatic Toxicity
FATE AND BEHAVIOR
Biodegradation
Bioaccumulation potential
PBT/vPvB conclusion

EXPOSURE

RESULT
Studies indicate that 12-Aminododecanoic acid is not toxic to fish
and to daphnia and has a low toxicity to algae and aquatic plants.
RESULT
12-Aminododecanoic acid is readily biodegradable.
12-Aminododecanoic acid has a low bioaccumulation potential.
Based on its low toxicity, bioaccumulation potential and readybiodegradability, 12-Aminododecanoic acid does not meet thecriteria for PBT or vPvB.

Human Health
12-Aminododecanoic acid is used in many different applications. 12-Aminododecanoic acid is used inindustrial applications as a monomer for the manufacture of polyamide, polymers, thermoplastics,
intermediate in the production of glue. 12-Aminododecanoic acid is also used in the laboratory as a reagent.
But its main industrial use is as monomer or reactant; therefore, 12-Aminododecanoic acid will no longer bepresent as such in downstream products, practically eliminating the exposure potential for consumers.
General population will not come in contact significantly with this chemical via environment due to theproduction of the substance as 12-Aminododecanoic acid is manufactured in closed processes which also
minimizes exposure potential to workers. The direct exposure of general population is very unlikely as thissubstance is manufactured in industrial settings for industrial/professional use. The polymerization is apolycondensation reaction above 200°C. Only vaporized water is released during the condensation reaction
and though if this water that contains 12-Aminododecanoic acid is a trace amount. Direct dermal contact
occurs only exceptionally during the handling of heated 12-Aminododecanoic acid and formulations, but
repeated daily exposure is unlikely.

Environment
The manufacture is a closed process and no significant exposure to the environment is expected. 12Aminododecanoic acid is solid at room temperature and it has low volatility in liquid form above its boilingpoint. Therefore, the probability of release in pure form to any of the environmental compartments is low,
under normal industrial use conditions. The polymerization is a polycondensation reaction above 200°C. Only
vaporized water is released during the condensation reaction and though if this water that contains 12Aminododecanoic acid is a trace amount. Any exposures will generally be lower than concern levels. Direct
use by the general population is not intended and thus environmental exposure via this route is unlikely tooccur.

RISK MANAGEMENT RECOMMENDATIONS

12-Aminododecanoic acid does not pose severe human health and it poses low environmental risks. After
repeated oral ingestion in rats, 12-Aminododecanoic acid showed adverse effects for kidney andhematological and blood chemical changes. Dermal and inhalation repeated dose exposure testing is notconducted, but it is considered that 12-Aminododecanoic acid does not have a high human health hazard
potential. Good ventilation is required in areas where 12-Aminododecanoic acid is handled. When usingchemicals make sure that there is adequate ventilation. Protective clothing, gloves and safety glasses withside shields should be worn when handling 12-Aminododecanoic acid. 12-Aminododecanoic acid is not
flammable; however, it is good practice to prevent the build-up of electrostatic charge when storing it. For

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Product Safety Summary for 12-Aminododecanoic Acidenvironmental protection in case of accidental release: do not allow product to reach sewage system or anywater course. Retain and dispose of contaminated wash water.
The usual general precautionary measures to prevent worker and environmental exposure to chemicals
should also be taken when handling 12-Aminododecanoic acid in industrial uses.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
12-Aminododecanoic acid is included in the OECD list of High Production Volume (HPV) chemicals.
12-Aminododecanoic acid is listed in the following Chemical Inventories: TSCA, EINECS, ENCS, KECI
12-Aminododecanoic acid is not listed in the following Chemical Inventories:
Canadian DSL, AICS, NZIoC, PICCS, IECSC

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Specific target organ toxicity- Repeated exposure:

Category 2; H373 May cause damage to organs (kidney, blood) throughprolonged or repeated oral exposure.

Labeling according to REGULATION (EC) No 1272/2008:

Pictogram:

Signal word:

Warning

Hazard statements:

H373: May cause damage to organs (kidney, blood) through prolonged orrepeated oral exposure.

CONTACT INFORMATION WITHIN COMPANY

For further information on this substance or product safety summaries in general, please contact:

Company:
Department:
Address:
Town/Country:
Postal code:
E-mail:UBE Chemical Europe, S.A
Product Liability
Poligono Industrial El Serrallo, s/nGrao de Castellon (Castellon), Spain
12100
sds.ube.eu@ube.es

Additional information can be found at:
http://www.ube.es
http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/

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GLOSSARY
Acute toxicity

Biodegradation
Bioaccumulation
Canadian DSL
Carcinogenicity
CAS

Chronic toxicity
EINECS

Flash point

Genotoxicity
GHS

HPV
Hydrolyze

Intermediate
Monomer
Mutagenicity
PBT
Persistence

Risk Management Measures
REACH (EC) No. 1907/2006
REGULATION (EC) No 1272/2008
Reprotoxicity
Sensitizing
Sediment

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Harmful effect resulting from a single or shortterm exposure to a substance.
Decomposition or breakdown of a substance undernatural conditions (actions of micro organismsetc).
Progressive accumulation in living organisms of achemical substance present in the environment.
Domestic Substances List of Canada.
Substance effects causing cancer.
Chemical Abstracts Service (division of theAmerican Chemical Society).
Harmful effect after repeated exposures or longterm exposure to a substance.
European Inventory of Existing Commercial
Chemical Substances
The lowest temperature at which vapor of thesubstance may form an ignitable mixture with air.
Substance effect that causes damage to genes,
including mutagenicity and clastogenicity.
Globally Harmonized System of Classification andLabelling of Chemicals
High Production Volume Chemicals.
Undergo hydrolysis; decompose by reacting withwater.
Substance that is manufactured for and consumed
in or used for chemical processing in order to betransformed into another substance.
Means a substance which is capable of forming
covalent bonds with a sequence of additional likeor unlike molecules under the conditions of therelevant polymer-forming reaction used for theparticular process.
Substance effect that cause mutation on genes.
Persistent, bioaccumulative, toxic chemical.
Refers to the length of time a compound stays in
the environment, once introduced.
Engineering controls, conditions and protectiveequipment needed to be implemented to ensurethat the risks to human health and theenvironment are adequately controlled.
European Commission Regulation concerning theRegistration, Evaluation, Authorisation andRestriction of Chemicals.
European Commission Regulation onClassification, Labelling and Packaging ofSubstances and Mixtures.
Including teratogenicity, embryotoxicity andharmful effects on fertility.
Allergenic.
Topsoil, sand and minerals washed from land into
water forming in the end a layer at the bottom ofPage 5

Product Safety Summary for 12-Aminododecanoic AcidTSCA
Vapor pressure
vPvB

rivers and sea.
Toxic Substance Control Act
A measure of a substance’s property to evaporate.
Very persistent, very bioaccumulative.

DATE OF ISSUE
March 2016

REVISION
Version 1.0

DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information isprovided in utmost good faith and has been based on the best information currently available, is to berelied upon at the user’s own risk. No representations or warranties are made with regards to its
completeness or accuracy and no liability will be accepted by UBE Chemical Europe, S.A for damages of
any nature whatsoever resulting from the use of or reliance on the information.

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