Revised in 2018 February•This product is a pharmaceutical product approved under a Japaneselaw, the Law for Ensuring the Quality, Efficacy and Safety of Drugs andMedical Devices, with a view to its sale and use in Japan.
•Multilingual product information is a translation of the product labeling
written in Japanese and provided for your information only. It does notwarrant that its contents and the product itself conforms to laws andregulations in countries other than Japan.
•Multilingual product information is a tentative translation by the provider(or Our Company), and may be modified or altered without notice.
•The provider (or Our Company) assumes no responsibility for any
problems that occur due to the contents of the multilingual productinformation.
You should read this written explanation before use.
Please keep it so that you can read it when you need to.

2nd Class OTC drug

Gastrointestinal
medicine
Seirogan Toi-A
The gastrointestinal medicine Seirogan Toi-A (sugar-coated tablet), is part of a product lineupthat includes Seirogan, a household medicine that has been used for over a century. JapanesePharmacopeia (JP) wood creosote, the main active ingredient of this medicine, regulates thewater balance in the intestines without stopping bowel peristalsis, and returns the intestinal
environment to its normal condition. It is especially effective for soft stool and diarrhea caused byfood poisoning, water poisoning and indigestion, and for soft stool and diarrhea due to stress andcold. This medicine is an odorless, easy-to-swallow white tablet, containing crude drugs such as
JP wood creosote, JP powdered geranium herb, and dry phellodendron bark extract.

[Precautions]
When not to use the product[If you do not follow these instructions, the current symptoms may worsen, or adverse
reactions/incidents may occur.]
1. This product should not be taken by the following persons.
(1) Patients who have had an allergic symptom (rash, redness, itching, oedema, etc.) to thisdrug or its ingredients(2) Patients undergoing dialysis
2. Do not take this medicine for a long time.

Consultation
1. The following persons should contact a physician, pharmacist, or registered salesperson for a consultation before administration.
(1) Patients undergoing medical treatment from a physician(2) Those who have diarrhea with a fever, bloody stool or persistent mucous stool(3) Pregnant women, women suspected of being pregnant, or nursing women(4) The elderly(5) Patients who have experienced allergic symptoms associated with drugs or cosmetics, etc.
(6) Patients with liver disease and/or renal disease
2. If the following symptoms are observed after taking this drug, these may be adverse
reactions, so immediately discontinue the use of this drug, and show this package
insert (instruction leaflet) to your physician, pharmacist, or registered salesperson for aconsultation.
Related area
Skin

Symptom
Rash/redness, itching, oedema

Gastrointestinal system

Nausea and vomiting, constipation, loss of appetite,
feeling of discomfort in the stomach

Neuropsychiatric system

Dizziness, headache(Continued overleaf)

3. When symptoms do not improve even after taking this medicine for 5 to 6 days, stoptaking this medicine and consult a physician, dentist, pharmacist or registeredsalesperson, being sure to take this package insert (instruction leaflet) with you.

[Indications]
Soft stool, diarrhea, food poisoning, water poisoning, diarrhea and vomiting, loose bowels
and diarrhea due to indigestion[Dosage and Directions]
Take the following dosages with cold or warm water within 30 minutes after a meal.
Age

One dose

Adults (15 years and older)

4 tablets

11-14 years of age

3 tablets

5-10 years of age

2 tablets

Daily dosage
3 times
Do not use

Under 5 years of age[Dosage and Administration Precautions](1) Follow the dosage and directions.
(2) When allowing children 5 years or over to take the medicine, a guardian must be present, andcaution must be exercised to prevent them from taking an incorrect dose or choking on it.

[Ingredients and Contents]
Every 12 tablets (maximum daily adult dosage) include the following ingredients.
Active IngredientsContent per tablet

EffectJP wood creosote*

270 mgNormalization of excessive colonic motility,
regulation of intestinal water content

JP powdered geranium herb

300 mg

Improvement of intestinal motility

Dried phellodendron barkessence

300 mg

Improvement of gastric function,
bacteriostasis inside the intestines[Inactive ingredients] Magnesium aluminum silicate, aluminum silicate, methyl cellulose,
CMC-Ca, hydroxypropyl cellulose and magnesium stearate. The sugar coating contains whitesugar, gum arabic, gelatin, talc, calcium carbonate, titanium dioxide, CMC-Na, macrogol,carnauba wax, and white beeswax.
*There are two types of substances generally called “creosote”: one is JP wood-tar creosote
derived from beechwood trees, and the other is industrial creosote (coal-tar creosote) extracted
from coal. However, these substances are completely different in terms of raw materials,components, and use. In addition, the results of carcinogenicity tests have demonstrated that JP
wood creosote is not identified as carcinogenic.
For more information or inquiries, please visit our website (http://www.seirogan.co.jp/) or contact
our customer service department.

[Storage and Handling Precautions]
1. Keep out of reach of children.
2. Do not transfer the medicine to a different container. (It may lead to misuse or alter thequality of the drug.)
3. Store in a cool place away from direct sunlight and keep it tightly closed.
4. Do not use after the use-by date indicated on the package.

Marketing authorization holder

3-34-14, Uchihonmachi, Suita Osaka, Japan 564-0032
01004102