Update November/4/2021

Haruhiko Siomi
PERSONAL DATA
Name:
Nationality:
Date of BirthWork address:

Haruhiko Siomi
Japan
June 11, 1959
Department of Molecular Biology
Keio University School of Medicine
35 Shinanomachi, Shinjuku
Tokyo 160-8582, Japan+81-3-5363-3754
0000-0001-8690-3822
https://researchmap.jp/read0079788

Phone:
Orcid:
Researchmap:
Google Scholar:
https://scholar.google.com/citations?user=VrN0XoUAAAAJ&hl=en
Email:Web:
EDUCATION
1982
1984
1988

AWARDS
2010
2008
2008
2006
2003
2000
1999
1998

1989
1988-1990

awa403@keio.jp
http://www.siomilab.med.keio.ac.jp/

B.A. Agricultural Chemistry
Valedictorian, Gifu University, Gifu, Japan
M.A. Organic Chemistry, Gifu University
Doctor of Medical Science (equivalent to Ph.D.)
Virology, Kyoto University, Japan

Mitsubishi Foundation award for Basic Natural
Sciences
The Naito Foundation Award
The Uehara Memorial Foundation Award
Takeda Science Foundation AwardFRAXA Research Foundation Award
Cure Autism Now (CAN) Foundation Pilot Research
Award
FRAXA Research Foundation AwardMRDDRC (Mental Retardation and Developmental
Disabilities Research Center) Young Investigator
Award
TONEN Fundamental Research Prize (nominatedby Molecular Biology Society of Japan)
Fellowship of the Japan Society for the Promotion of
Science for Japanese Junior Scientists

PROFESSIONAL EXPERIENCE
2008-present: Head and Professor, Department of Molecular Biology,
Keio University School of Medicine, Tokyo, Japan
2008-present: Visiting Professor, Institute of Advanced Medical Sciences,
Tokushima University

2018-present: Guest Professor, Research Institute for Microbial Diseases,
Osaka University
1999-2008: Professor, Institute for Genome Research, University ofTokushima, Tokushima, Japan
1997-1999: Research Assistant Professor, Department of Biochemistry
and Biophysics, University of Pennsylvania School of Medicine
1996-1997: Research Associate, University of Pennsylvania School of
Medicine
1990-1996: Associate, Howard Hughes Medical Institute, University ofPennsylvania School of Medicine, (adviser: Dr. Gideon Dreyfuss)
1988-1990: JSPS Research Fellow, Institute for Virus Research, Kyoto
University, Japan (adviser: Professor Yoshiaki Ito & Dr. Hisatoshi Shida)
PROFESSIONAL MEMBERSHIP
Member
The RNA Society (Organizer of the 2011 annual
Meeting at Kyoto; Director, 2017 – 2018; member ofthe 2021 RNA Society Nominating Committee)
President
The RNA Society of Japan (2010-2014)
Member
The Molecular Biology Society of Japan(Board member 2010-2013, 2015- 2018, 2021-2022)
MemberJapan Society for Cell Biology
MemberJapanese Society of Developmental
Biologists (Board member 2010-2013)
Co-ChairTokyo RNA Club (2008- present)
UNIVERSITY ACTIVITIES
2008-present Thesis advisory committee member
2015-present Committee for The Keio Medical Science Prize,(2020- Chair)2015-presen Director of RI Technical Training Center the Keio
University School of Medicine
2015-present Director of Genetic Modification Safety Committee the
Keio University School of Medicine
2016-2019
Director of Committee on Research Development the Keio
University School of Medicine
2019-present JKiC (JSR-Keio Innovation Center) adviser
2021Vice Dean (in charge of research)
TEACHING
2000-present
2008-present
2019- 2021
2015-present
FUNDING2019-2024

Introductory Molecular Biology (Lecture course, ~100
students)
Molecular Biology (Graduate Program core course, ~80
students)
Genome Science (Lecture course, ~40 students)
Okayama University Dental School Guest Lecture

MEXT Grant-in-Aid for Scientific Research on Innovative
Areas “Program for Totipotency”

2017-2022

2013-2018

2008-20132004-2008
2003-2006

2001-2006

Japan Agency for Medical Research and Development(AMED), Project for Elucidating and Controlling
Mechanisms of Aging and Longevity
JSPS Grant-in-Aid for Scientific Research (S) “Molecularpathways leading to epigenome formation in mammaliangerm cells (No. 25221003)”
JSPS Grant-in-Aid for Scientific Research (S) “Fathoming
the evolution of gene regulation through an ‘arms race’
between transposons and Argonautes (No. 20221008)”
MEXT Genome Network Project “Characterization of noncoding RNA-mediated regulation of gene expression”
JSPS
Grant-in-Aid
for
Scientific
Research(A)“Understanding of gene networks that control behaviors
through characterizing the hereditary mental retardation gene
FMR1”
JSPS Grant-in-Aid for Scientific Research on Priority Areas:
Spatiotemporal Network of RNA Information Flow,“Understanding of regulatory mechanisms mediated by RNAbinding proteins”

REVIE ACTIVITIESJournals:
Cell, Nature, Science, Genes & Development, Nature Cell Biology, PLoS
Biology, eLife, Molecular Cell, Developmental Cell, Development, PLoS
Genetics, Nature Structural & Molecular Biology, Current Biology, Nature
Review Molecular Cell Biology, Nature Review Genetics, Nature
Biotechnology, Nature Chemical Biology, Nature Communications, Nature
Protocols, RNA, PNAS, EMBO J, EMBO Reports, Cell Reports, PLoS
Computational Biology, PLoS Neglected Tropical Diseases, Trends in
Biochemical Sciences, Trends in Genetics, Trends in Immunology, Nucleic
Acids Research, Genome Research, Molecular and Cellular Biology,
Genetics, Journal of Biological Chemistry, Mobile DNA, Cancer Research,
Molecular Biology of the Cell, Biochemical Society Transactions, Genome
Biology, Human Molecular Genetics, Developmental Biology, Journal of
Theoretical Biology, etc.
Grants:The Austrian Genome Research Programme GEN-AU, The Japan Society
for the Promotion of Science (Japan), MEXT, NIH (USA), Wellcome Trust,
The Fund for Scientific Research – Flanders (Belgium)(FWO), Austrian
Science Fund (The START Programme), National Science Foundation(USA), Academic Summit Program/National Science Council (Republic ofChina), The Division for Chemical Sciences (CW) of the Netherlands
Organisation for Scientific Research (NWO), Association for International
Cancer Research (AICR), University of Antwerp (Belgium), Swiss National
Science Foundation, Netherlands Organisation for Scientific Research,
Earth and Life Sciences (NWO), The French National Research Agency(ANR), European Commission (erc)/European Research Council,
Executive Agency (ERCEA), NWO (Chemical Sciences), HFSP Career
Development Award program, The 2019 Research Grant awards from the
HFSP, ERC Advanced Grant, National Science Centre (Narodowe

Centrum Nauki-NCN), Poland, The John Templeton Foundation, The
Deutsche Forschungsgemeinschaft (German Research Foundation, DFG),
Life Sciences 1: Molecular and Organismic Biology
EXTERNAL SERVICE-Committee of Fellowship of the Japan Society for the Promotion of
Science for Japanese (JSPS) Junior Scientists, 2003-2005-Adviser of JST PRESTO on ‘RNA and its biofunctions,’ 2006-2012-Committee of Japan Science and Technology Agency (JST) biology
division, 2008-2012-Advisory committee of JBiC on ‘Functional RNA’ project, 2009-2010-Advisory Board of National Institute for Basic Biology, 2009-2013-Advisor of MEXT Grant-in-Aid for Scientific Research on Innovative
Areas (‘RNA program’), 2008-2012-Advisor of MEXT Grant-in-Aid for Scientific Research on Innovative
Areas (‘Genome adaptation’), 2010-2014-Advisor of MEXT Grant-in-Aid for Scientific Research on Innovative
Areas (‘Transcription cycle’), 2012-2016-Member of the 2014 Japan Prize Selection Committee for the Life
Science field, 2013-2014-Scientific advisory committee for Ministry of Education, Culture, Sports,
Science and Technology-Japan, 2012-2016-Advisor of MEXT Grant-in-Aid for Scientific Research on Innovative
Areas (‘Chromosome orchestration system’), 2012-2016-Program Officer of the Research Center for Science Systems, JSPS,
2016~2020-Riken Associate Chief Scientist Research Review committee, chair, 2016
-Member of the Director-general selection committee for National Institutefor Basic Biology, NINS, 2016-2017-Director of JST CREST/PRESTO on ‘Large-scale genome synthesis andcell programming’, 2018-2025
EDITORIAL BOARDS-RNA Biology, Editorial Board, 2019~ present-RNA, Editorial Board, 2018~ present-Molecular Genetics and Genomics, Editorial Board, 2014~ present-Mobile DNA, Editorial Board, 2014~ present-EMBO reports, Advisory Editorial Board, 2012~2017-Development, Growth & Differentiation, Guest Editor for a special issueof ‘RNA and Development’, 2011
-Nucleic Acids Research, Editorial Board, 2010~ present-Genes to Cells, Associated Editor, 2009~ present
Ad hoc EXTERNAL REVIWER-IBM Thomas J Watson Research Center, NY (evaluation of aManager at Computational Biology Center), 2010
-IMBA, Vienna (evaluation of PIs for renewal), 2010
-Thomas Jefferson University, Philadelphia (evaluation of PI for
appointment to Professor), 2011
-Kazusa DNA Research Institute (evaluation of three IPs for renewal),
2012~2014

-Osaka University (evaluation of PI for Life Science Young Independent
Researcher Support Program), 2013
-Sloan-Kettering Institute, New York (evaluation of PI for promotion toMember), 2013
-Tokyo Medical and Dental University (evaluation of Associate
Professor), 2013
-Institute for Virus Research, Kyoto University (evaluation of Professor),
2013-City University of Hong Kong (evaluation of Assistant Professor for
substantiation of tenured appointment & promotion), 2015
-University of Minnesota, Minneapolis, MN (evaluation of AssistantProfessor for substantiation of tenured appointment & promotion), 2017
-Riken (evaluation of PIs), 2016, 2017, 2018
-Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences(SIBCB, CAS), Shanghai, (evaluation of PI for promotion to Senior
Investigator with tenure), 2017
-Johns Hopkins University School of Medicine, Baltimore (evaluation of PI
for promotion to Associate Professor), 2018
-NIH/NIAMS, Bethesda (evaluation of PI for promotion to Senior
Investigator), 2018
-Department of Agricultural Biotechnology, Seoul National University,(evaluation of Associate Professor for promotion to Professor), 2018
-The Neurobiology, Biochemistry and Biophysics School, Tel-Aviv
University, Israel (evaluation of Associate Professor for promotion to fullProfessor), 2019
-Division of Biological Sciences, Indian Institute of Science, Bangalore,
India (evaluation of Assistant Professor for promotion to tenured Associate
Professor), 2019
STUDENTS/POSTDOCTORAL FELLOWS
Thesis mentor to 14 PhD students
Research mentor to 16 post-doctoral fellows.

BIBLIOGRAPHY
PUBLICATIONS(PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Siomi+H&sort=date)
Selected:
Matsunami, N., Siomi, H., Hatanaka, M., Yaoita, Y. and Honjo, T. 1986.
Preferential transcription of HTLV-I LTR in cell-free extracts of human T
cells producing HTLV-I viral proteins. Nucleic Acids Res. 14: 4779-4786.
Siomi, H., Shida, H., Nam, S-H., Nosaka, T.,Maki, M. and Hatanaka, M.
1988. Sequence requirements for nucleolar localization of human T cellleukemia virus type I pX protein, which regulates viral RNA processing.
Cell 55: 197-209.
Siomi, H., Matunis, M. J., Micheal, W. M. and Dreyfuss, G. 1993. The premRNA binding K protein contains an evolutionarily conserved motif.
Nucleic Acids Res. 21: 1193-1198.

Siomi, H., Siomi, M. C., Nussbaum, R. L. and Dreyfuss, G. 1993. The
protein product of the fragile X gene, FMR1, has characteristics of an RNAbinding protein. Cell 74: 291-298.
Siomi, H., Choi, M., Siomi, M. C. Nussbaum, R. L. and Dreyfuss, G. 1994.
Essential role for KH domains in RNA binding: impaired RNA binding by amutation in the KH domain of FMR-1 that causes fragile X syndrome. Cell
76: 33-39.
Siomi, H. and Dreyfuss, G. 1995. A nuclear localization domain in the
hnRNP A1 protein. J. Cell Biol. 129: 551-560.
Siomi, M. C., Siomi, H., Sauer, W. H., Srinivasan, S., Nussbaum, R. L.
and Dreyfuss, G. 1995. FXR1, an autosomal homologue of the fragile X
mental retardation gene. EMBO J. 14: 2401-2408.
Tabara, H., Yigit, E., Siomi, H. and Mello, CC. 2002. The double-stranded
RNA binding protein RDE-4 interacts in vivo with RDE-1, DCR-1 and aconserved DExH-box helicase to direct RNA interference in C. elegans.
Cell 109:861-871.
Inoue, SB., Shimoda, M., Nishinokubi, I., Siomi, MC., Okamura, M.,
Nakamura, A., Kobayashi, S., Ishida, N. and Siomi, H. 2002. A role for the
Drosophila fragile X related gene in the circadian output. Current Biology
12: 1331-1335.
Ishizuka, A., Siomi, MC. and Siomi, H. 2002. A Drosophila fragile X protein
interacts with components of RNAi and ribosomal proteins. Genes &Development 16: 2497-2508.
Okamura, K., Ishizuka, A., Siomi, H., and Siomi, MC. 2004. Distinct roles
for Argonaute proteins in small RNA-directed RNA cleavage pathways.
Genes & Development 18: 1655-1666.
Saito, K., Ishizuka, A., Siomi, H., and Siomi, MC. 2005. Processing of premicroRNAs by the Dicer-1-Loquacious complex in Drosophila cells. PLoS
Biology 3(7): e235.
Miyoshi, K., Tsukumo, H., Nagami, T., Siomi, H., and Siomi, MC. 2005
Slicer function of Drosophila Argonautes and its involvement in RISC
formation. Genes & Development 19: 2837-2848.
Saito, K., Nishida, KM., Mori, T., Kawamura, Y., Miyoshi, K., Nagami, T.,
Siomi, H., and Siomi, MC. 2006. Specific association of Piwi with
rasiRNAs derived from retrotransposon and heterochromatic regions in the
Drosophila genome. Genes & Development 20: 2214-2222.
Gunawardane, LS., Saito, K., Nishida, KM., Miyoshi, K., Kawamura, Y.,
Nagami, T., Siomi, H., and Siomi, MC. 2007. A Slicer-mediatedmechanism for rasiRNA 5’end formation in Drosophila. Science 315:
1587-1590.
Saito, K., Sakaguchi, Y., Suzuki, T., Suzuki, T., Siomi, H., and Siomi, MC.
2007. Pimet, the Drosophila homolog of HEN1, mediates 2’-O-methylationof Piwi-interacting RNAs at their 3’ ends. Genes & Development 21:
1603-1608.
Azuma-Mukai, A., Oguri, H., Kin, T., Qian, ZR., Asai, K., Siomi, H., andSiomi, MC. 2008. Characterization of endogenous human Argonautes andtheir miRNA partners in RNA silencing. Proc. Natl. Acad. Sci. USA.
105:7964-7969.
Kawamura, Y., Saito, K., Kin, T., Ono, Y., Asai, K., Sunohara, T., Okada,NT., Siomi MC. and Siomi, H. 2008. Drosophila endogenous small RNAsbind to Argonaute2 in somatic cells. Nature 453: 793-797.

Saito, K., Inagaki, S., Mituyama, T., Kawamura, Y., Ono, Y., Sakota, E.,
Kotani, H., Asai, K., Siomi H. and Siomi, MC. 2009. A regulatory circuit forpiwi by traffic jam, a large Maf, in Drosophila gonadal somas. Nature 461:
1296-1299.
Nishida, KM., Okada, TN., Kawamura, T., Mituyama, T., Kawamura, Y.,
Inagaki, S., Huang, H., Chen, D., Kodama, T., Siomi, H., and Siomi, MC.
2009. Functional involvement of Tudor and dPRMT5 in the piRNA
processing pathway in Drosophila germlines. EMBO J. 28: 3820-3831.
Miyoshi, T., Takeuchi, A., Siomi, H. and Siomi, M.C. 2010. A direct role of
Hsp90 in pre-RISC formation in Drosophila. Nature Structural andMolecular Biology 17: 1024-1026.
Nagao, A., Mituyama, T., Huang, H., Chen, D., Siomi, MC., Siomi, H. 2010.
Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila.
RNA 16: 2503-2515.
Saito, K., Ishizu, H., Komai, M., Kotani, H., Kawamura, Y., Nishida, KM.,
Siomi, H., and Siomi, MC. 2010. Roles for the Yb body components
Armitage and Yb in primary piRNA biogenesis in Drosophila. Genes &Development 24: 2493-2498.
Cernilogar, F.M., Onorati, M.C., Kothe, G.O., Burroughs, A.M., Parsi, K.M.,
Breiling, A., lo Sardo, F., Saxena, A., Miyoshi, K., Siomi, H., Siomi, M.C.,
Carninci, P., Gilmour, D.S., Corona, D.F.V., and Orlando, V. 2011.
Chromatin-associated RNAi components contribute to transcriptional
regulation in Drosophila. Nature 480: 391-395.
Sato, K., Nishida, K.M., Shibuya, A., Siomi, M.C., and Siomi, H. 2011.
Maelstrom coordinates microtubule organization during Drosophila
oogenesis through interaction with components of the MTOC. Genes &Development 25: 2361-2373.
Nishimasu, H., Ishizu, H., Saito, K., Fukuhara, S., Kamatani, MK.,
Matsumoto, N., Nishizawa, T., Bonnefond, L., Nakanaga, K., Aoki, J.,
Ishitani, R., Siomi, H., Siomi, MC., and Nureki, O. 2012. Structure andfunction of Zucchini endoribonuclease in piRNA biogenesis. Nature 491:
284-287.
Nishida, KM., Miyoshi, K., Ogino, A., Miyoshi, T., Siomi, H. and Siomi, MC.
2013. Roles of R2D2, a cytoplasmic D2 body component, in theendogenous siRNA pathway in Drosophila. Molecular Cell 49: 680-691.
Ohtani, H., Iwasaki, YW., Shibuya, A., Siomi, H., Siomi, MC., and Saito,
K. 2013. DmGTSF1 is necessary for Piwi–piRISC-mediated transcriptionaltransposon silencing in the Drosophila ovary. Genes & Development 27:
1693-1705.
Hirano, T., Iwasaki, YW., Lin, ZYC., Imamura, M., Seki, NM., Sasaki, E.,
Saito, K., Okano, H., Siomi, MC., and Siomi, H. 2014. Small RNA profilingand characterization of piRNA clusters in the adult testes of the common
marmoset, a model primate. RNA 20: 1223-1237.
Sato, K., Iwasaki, YW., Shibuya, A., Carninci, C., Tsuchizawa, Y., Ishizu,
H., Siomi. MC., and Siomi, H. 2015. Krimper enforces an antisense bias
on piRNA pools by binding AGO3 in the Drosophila germline. Molecular
Cell 59: 553-563.
Ishizu, H., Iwasaki, Y.W., Hirakata, S., Ozaki, H., Iwasaki, W., Siomi, H.,
and Siomi, M.C. 2015. Somatic primary piRNA biogenesis driven by cisacting RNA elements and trans-acting Yb. Cell Reports 12: 426-440.

Shibata, N., Kashima, M., Ishiko, T., Nishimura, O., Rouhana, L., Misaki,
K., Yonemura, S., Saito, K., Siomi, H., Siomi, MC., and Agata, K. 2016.
Inheritance of a nuclear PIWI from pluripotent stem cells by somatic
descendants ensures differentiation by silencing transposons in planarian.
Dev Cell 37: 226-237.
Iwasaki, YW., Murano, K., Ishizu, H., Shibuya, A., Iyoda, Y., Siomi, MC.,
Siomi, H., and Saito, K. 2016. Piwi modulates chromatin accessibility by
regulating multiple factors including histone H1 to repress transposons.
Mol Cell 63: 408-419.
Sumiyoshi, T., Sato, K., Yamamoto, H., Iwasaki, YW., Siomi, H., andSiomi, MC. 2016. Loss of l(3)mbt leads to acquisition of the ping-pongcycle in Drosophila ovarian somatic cells. Genes & Development 30:
1617-1622.
Matsumoto, N., Nishimasu, H., Sakakibara, K., Nishida, KM., Hirano, T.,
Ishitani, R., Siomi, H., Siomi, MC., and Nureki, O. 2016. Crystal structureof silkworm PIWI-clade Argonaute Siwi bound to piRNA. Cell 167: 484497.
Nishida, KM., Sakakibara, K., Iwasaki, YW., Yamada, H., Murakami, R.,
Murota, Y., Kawamura, T., Kodama, T., Siomi, H., and Siomi, MC. 2018.
Hierarchical roles of mitochondrial PAPI and Zucchini in Bombyx germline
piRNA biogenesis. Nature 555: 260-264.
Murano, K., Iwasaki, Y.W., Ishizu, H., Mashiko, A., Shibuya, A., Kondo, S.,
Adachi, S., Suzuki, S., Saito, K., Natsume, T., Siomi, M.C., and Siomi, H.
2019. Nuclear RNA export factor variant initiates Piwi–piRNA-guided cotranscriptional silencing. EMBO J. 38: e102870.
Yamanaka, S., Nishihara, H., Toh, H., Nagai, LAE., Hashimoto, K., Park,
S-J., Shibuya, A., Suzuki, AM., Tanaka, Y., Nakai, K., Carninci, P., Sasaki,
H., and Siomi, H. 2019. Broad heterochromatic domains open in gonocyte
development prior to de novo DNA methylation. Developmental Cell 51:
21-34.
Onishi, R., Sato, K., Murano, K., Siomi, H., and Siomi, MC. 2020. Piwi
suppresses transcription of Brahma-dependent transposons via
Maelstrom in ovarian somatic cells. Science Advances 6: eaaz7420
Ishino, K., Hasuwa, H., Yoshimura, J., Iwasaki, Y.W., Nishihara, H., Seki,
N. M., Hirano, T., Tsuchiya, M., Ishizaki, H., Masuda, H., Kuramoto,T., Saito, K., Sakakibara, Y., Toyoda, A., Itoh, T., Siomi, M.C., Morishita,S., Siomi, H. 2021. Hamster PIWI proteins bind to piRNAs with stage-specificsize variations during oocyte maturation. Nucleic Acids Research. 49: 27002720.
Iwasaki, YW., Sriswasdi, S., Kinugasa, Y., Adachi, J., Horikoshi, Y.,
Shibuya, A., Iwasaki, W., Tashiro, S., Tomonaga, T., and Siomi, H. 2021.
Piwi-piRNA complexes induce spatial changes in nuclear architecture toinduce stepwise heterochromatin formation. EMBO J 40: e108345.
Hasuwa, H., Iwasaki, Y.W., Kin, A.Y.W., Ishino, K., Masuda, Sasaki,
H., Siomi. 2021. Production of functional oocytes requires maternallyexpressed PIWI genes and piRNAs in golden hamsters. Nature Cell
Biology 23: 1002-1012.
REVIEWS, NEWS & VIEWS, and BOOK CHAPTERS
Selected:Siomi, H. and Dreyfuss, G. 1997. RNA-binding proteins as regulators ofgene expression. Curr. Opin. Genet. Dev. 7:345-353.
Siomi, H., Ishizuka, A and Siomi, MC. 2004. RNA Interference: A New
Mechanism by Which FMRP Acts in the Normal Brain? - What can
Drosophila teach us? – MRDDR review, 10: 68-74.
Siomi, H. and Siomi, MC. 2007. Expanding RNA physiology: microRNAs
in a unicellular organism. Genes & Development 21: 1153-1156.
Siomi, H., and Siomi, MC. 2009. On the road to reading the RNAinterference code. Nature 457: 396-404.
Siomi, H., and Siomi, MC. 2009. RISC hitches onto endosome trafficking.
Nature Cell Biology 11: 1049-1051.
Siomi, M.C., Mannen, T., and Siomi, H. 2010. How does the royal familyof Tudor rule the Piwi-interacting RNA pathway? Genes & Development
24: 636-646.
Siomi, H., and Siomi, MC. 2010. Posttranscriptional regulation of miRNAbiogenesis in animals. Molecular Cell 38: 323-332.
Miyoshi, K., Miyoshi, T., and Siomi, H. 2010. Many ways to generate
microRNA-like small RNAs: noncanonical pathways for microRNA
production. Molecular Genetics and Genomics 284: 95-103.
Siomi, H., and Siomi, MC. 2011. Preview: Stress signaling etches
heritable marks on chromatin. Cell 145: 1005-1007.
Ishizu, H., Siomi, H., and Siomi, MC. 2012. Biology of PIWI-interacting
RNAs: new insights into biogenesis and function inside and outside ofgermlines. Genes & Development 26: 2361-2373.
Siomi, H. 2014. It’s time to exploit your favorite quirky organism with newtechnologies. EMBO Rep 15: 620-621.
Yamanaka, S., Siomi, MC. and Siomi, H. 2014. piRNA clusters and open
chromatin structure. Mobile DNA 5:22 .
Iwasaki, YW and Siomi, H. 2014. miRNA regulatory ecosystem in early
embryogenesis. Molecular Cell 56: 615-616.
Iwasaki, YW, Siomi, MC and Siomi, H. 2015. PIWI-interagting RNA: Its
Biogenesis and Functions. Annu Rev Biochem. 84:405-433.
Hirano, T., and Siomi, H. 2015. Small RNA-directed chromatin
modification: Transgenic systems producing artificial piRNAs in germ cells.
Curr Biol. 25: R280-R283.
Siomi, H., and Siomi, MC. 2015. Phased piRNAs tackle transposons.
Science 348: 756-757.
Yamanaka, S., and Siomi, H. 2015. Misprocessed tRNA response targets
piRNA clusters. EMBO J. 34: 2988-2989.
Hasuwa, H., and Siomi, H. 2017. Mobile elements control stem cellpotency. Science 355: 581-582.
Murano, K., Gu, Y., and Siomi, H. 2021. The emergence of SARS-CoV-2
variants threatens to decrease the efficacy of neutralizing antibodies andvaccines. Biochemical Society Transactions in press.
DEPERTMENT SEMINARS and SYMPOSIUM TALKS
Selected:
Columbia University College of Physicians & Surgeons, Department of
Genetics and Development, New York, NY, March 1996.
New York University Medical Center, Department of Biochemistry, New
York, NY, December 1996.

University of Pennsylvania, Department of Biochemistry and Biophysics,
Philadelphia, PA, February 1997.
University of British Columbia, Centre for Molecular Medicine andTherapeutics, Vancouver, Canada, September 1997
Speaker as a member of the faculty at the Sixth International Fragile X
Conference, Asheville, North Carolina, July 1998
University of Connecticut Health Center, Farmington, Connecticut,
November 1998
University of Tokyo, Department of Chemistry and Biotechnology,
Graduate School of Engineering, Tokyo, Japan, December 1998
Tokyo Medical and Dental University Human Gene Sciences Center,
Tokyo, Japan, December 1998
Kanazawa University Cancer Research Institute, Kanazawa, Japan,
December 1998
RIKEN Brain Science Institute, Wako, Saitama, Japan, February 1999
Max-Plank Institute for Biochemistry, Munich, Germany, July 1999
Ringberg Meeting on RNA-Metabolism and Neurological Diseases,
Ringberg Castle, Bavaria, Germany, May 2000
Understanding The Neural Basis of Fragile X Meeting, Banbury Center,
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, March
2001
10th International Workshop on Fragile X and X-linked mental retardation,
Villa Tuscolana, Frascati, Italy, September 2001
Speaker at the 8th International Fragile X Conference, Chicago, July 2002.
Speaker at the 9th International Fragile X Conference, Washington DC,
June 2004.
The Eighth US-Japan Cellular and Gene Therapy Conference on RNA
Therapy, Natcher Conference Center, NIH, Bethesda, Maryland, February
2005.
CDB Symposium 2006 –Logic of Development: New Strategies andConcepts, Kobe, Japan, April 2006.
CAS International Symposium on Model Organisms and Diseases, Beijing,
October 2006
Institute of Genetics and Developmental Biology, Chinese Academy of
Sciences, Beijing, China, January 2008
The 65th KSBMB annual meeting, KSMBMB-KSBMB joint symposium on
RNA Biology, Seoul, Korea, May 2008
RiboClub 2008 Opening Session Program, ‘Tiny RNAs-big players in the
RNA world’, Sherbrooke, Quebec, Canada, September 2008
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan,
October 2008
20th FAOBMB Taipei Conference ‘Frontier in Life Sciences’, Symposium“RNA biology and Gene regulation” (moderator: Woan-Yuh Tarn &Haruhiko Siomi), Yang-Ming University, Taiwan, October 2008
National Institute of Biological Sciences, Beijing, China, December 2008
The 4th International Workshop on Cell Regulations in Division and Arrest,
OIST, Okinawa, Japan, December 2009
Genetics Seminar Program, Yale University School of Medicine, New
Haven, January 12, 2010
Plenary Lecture, RNA Symposium 2010 (the 3rd RNA molecular Biology
meeting of Taiwan), National Cheng Kung University, Tainan, Taiwan

February 8-9, 2010
“Bingzhi Forum” speaker at Institute of Zoology, Chinese Academy of
Sciences, Beijing, China, June 15, 2010
International symposium on Control of Gene Expression and Cancer,
dedicated to the 20th anniversary of the Institute of Gene Biology, Russian
Academy of Sciences, Moscow, Russia, June 21-25, 2010
International Centre for genetic engineering and biotechnology (ICGEB)European Science Foundation (ESF) Workshop on RNA processing in
biology and medicine, Beijing, China, October 20-22, 2010
The New York Academy of Sciences, “Piwi-interacting RNAs (piRNAs), theguardians of the germ-line stem cell genome –Biogenesis and Function-,
New York, November 3, 2010
Memorial Sloan-Kettering Cancer Institute, New York, November 4, 2010
CGC/CBG meeting Epigenetics and non-coding RNAs, Koninklijk Instituutvoor de Tropen, Amsterdam, November 10, 11, 2011
The 3rd Shanghai International Conference of Epigenetics in Development
and Diseases/The 7th Annual Conference of Asian Epigenome
Alliance/Genome Medicine Workshop on Epigenetic (-moic)s in Diseases,
Shanghai, China, April 19-22, 2012
63rd Fujihara Seminar, “A new horizon of retroposon research”, Kyoto, July
31 – August 3, 2012
Radiation Effects research Foundation, International Workshop: RERF
Radiation Research in the Post-genome Era, Hiroshima, March 7-8, 2013
HMG2013 & 21st ICG Singapore: Noncoding RNAs & miRNAs, Singapore
April 13, 2013
Institute of Molecular Genetics, Moscow, Russia, September 2, 2013
Institute of Genetics and Developmental Biology, Chinese Academy of
Sciences, Beijing, China, September 10, 213
Keystone Symposia “RNA Silencing”, Seattle, USA, January 31 –February 5, 2014
Opening lecture, Current Methods in RNP Analysis (Graduate researchcourse), University of Regensburg, Germany, July 21-25, 2014
The Russia-Japan joint meeting on small RNAs and germline development,
Saint Petersburg University, Saint Petersburg, Russia, August 5, 2014
Symposium on RNA Biology, ComBio2014, Canberra, Australia, October
2, 2014
Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological
Sciences, Chinese Academy of Sciences, Shanghai, China, November 10,
2014
RNA Biology, CSH-Asia conference, Suzhou, China, November 11, 2014
Keynote lecture, The World of Regulatory RNAs, Tel Aviv University, TelAviv, Israel, May 7, 2015
College of Agriculture and Life Sciences, Seoul National University, Seoul,
Korea, June 24, 2015
The keynote lecture, The 4th annual meeting of the RNA Society of Taiwan,
National Cheng Kung University, Tainan, Taiwan, September 26-27, 2016
The keynote lecture, Mini-Symposium on ncRNA, Academia Sinica, Taipei,
Taiwan, September 29, 2016
NUS-KEIO joint scientific symposium “Frontiers if translational medicine –From cradle to aging”, National University of Singapore, Singapore,
January 10-11, 2017

Institute of Zoology, CAS, Beijing, China, February 2, 2017
Japan-Russia Symposium on piRNA Silencing, Institute of Molecular
Genetics, RAS, Moscow, Russia, March 13-14, 2017
TEMASEK lifesciences laboratory, Singapore, December 13, 2017
Cancer Science Institute of Singapore, National University of Singapore,
Singapore, December 14, 2017
Japanese-Russian symposium on piRNA silencing and heterochromatin,
Institute of Molecular Genetics, Moscow, March 13-14, 2018
Rockefeller University, New York, May 22, 2018
Cincinnati Children’s Hospital Medical Center, May 24, 2018
piRNAs and PIWI proteins, EMBO Workshop, Montpellier, France,
September 12 – 15, 2018
Cell Biology, Developmental Biology, and Systems Biology Course
Meeting, Kyoto University School of Medicine, September 21, 2018
Japanese-Russian Symposium on piRNA Silencing, Institute of molecular
genetics, RAS, October 29-30, 20182018 IBS Conference on RNA Biology Seoul National University, Seoul,
Korea, November 5-7, 2018
40th Annual Lorne Genome Conference, Lorne, Australia, February 17-19,
2019
Institute of Biochemistry and Cell Biology, Shanghai Institutes of
Biological Sciences, Chinese Academy of Sciences, Shanghai, China,
May 16, 2019
School of Life Science and Technology, ShanghaiTech University,
Shanghai, China, May 17, 2019
NIG Meeting on chromosome, chromatin and nuclear dynamics, National
Institute of Genetics, Mishima, June 5-6, 2019
Institute of Molecular Embryology and Genetics, Kumamoto University,
Kumamoto, December 18, 2019
Cold Spring Harbor Laboratory meeting on Regulatory & Non-coding
RNAs, Cold Spring Harbor, NY, May 12 – 15, 2020 (the virtual Zoom
meeting due to the SARS-Cov-2 pandemic).
The BBSRC-JST UK-Japan Virtual Workshop in Synthetic Biology,
October 23, 2020 (Speaker, moderator and session chair: the virtual Zoom
meeting due to the SARS-Cov-2 pandemic).
LECTURES for HIGH SCHOOL, UNDERGRADUATE, or GRADUATESTUDENTS
Hokkaido University, 2000
Kumamoto University, 2002
University of Tokyo, 2003
Nagoya University, 2004
Tokyo Medical and Dental University, 2007
Kyoto University, 2008
University of Tokyo, 2009
Tokyo Institute of Technology, 2009
Nagoya University, 2010
Hokkaido University, 2010
Toyama University, 2010
Special lecture for selected high school students @ Keio, 2010
Toyama University, 2012

Meiwa High School SSH program, 2012
Toyama University, 2014
Kurashiki Amagi High School SSH program, 2019