Revised in February 2018

•This product is a pharmaceutical product approved under a Japaneselaw, the Law for Ensuring the Quality, Efficacy and Safety of Drugs andMedical Devices, with a view to its sale and use in Japan.
•Multilingual product information is a translation of the product labeling
written in Japanese and provided for your information only. It does notwarrant that its contents and the product itself conforms to laws andregulations in countries other than Japan.
•Multilingual product information is a tentative translation by the provider(or Our Company), and may be modified or altered without notice.
•The provider (or Our Company) assumes no responsibility for any
problems that occur due to the contents of the multilingual productinformation.

You should read this written explanation before use.
Please keep it so that you can read it when you need to.

2nd Class OTC drug

Gastrointestinal
medicine
Seirogan
The gastrointestinal medicine Seirogan is a household medicine which has been usedfor over a century.
Japanese Pharmacopeia (JP) wood creosote, the main active ingredient of thismedicine, regulates the water balance in the intestines without stopping bowel
peristalsis, and returns the intestinal environment to its normal condition.
It is especially effective for soft stool and diarrhea caused by food poisoning, water
poisoning and indigestion, and for soft stool and diarrhea due to stress and cold.
This medicine comes in the form of a soft tablet containing water and crude drugs,
such as JP wood creosote, JP powdered gambir, JP powdered phellodendron bark, JP
powdered glycyrrhiza, and powdered citrus unshiu peel.

[Precautions]
When not to use the product[If you do not follow these instructions, the current symptoms may worsen, or
adverse reactions/incidents may occur.]
1. This product should not be taken by the following persons.
Patients who have had an allergic symptom (rash, redness, itching, oedema, etc.) to thisdrug or its ingredients.
2. Toothaches can be temporarily relieved with this medicine, but the product does
not have a therapeutic effect. Therefore, seek treatment from a dentist
immediately even if the pain subsides. When the pain ceases, make sure to takethis medicine away from the cavity. Do not leave it there.

Consultation
1. The following persons should contact a physician, dentist, pharmacist, orregistered salesperson for a consultation before administration.
(1) Patients undergoing medical treatment from a physician or dentist(2) Those who have diarrhea with a fever, bloody stool or persistent mucous stool(3) Pregnant women, women suspected of being pregnant or nursing women(4) The elderly(5) Patients who have experienced allergic symptoms associated with drugs orcosmetics, etc.
(6) Patients with liver disease and/or renal disease
2. If the following symptoms are observed after using this drug, these may be
adverse reactions, so immediately discontinue the use of this drug, and show thispackage insert (instruction leaflet) to your physician, dentist, pharmacist, orregistered salesperson for a consultation.
Related area
Skin

Symptom
Rash/redness, itching, oedema
Nausea and vomiting, constipation, loss of appetite,
Gastrointestinal system
feeling of discomfort in the stomach
Neuropsychiatric system Dizziness, headache(Continued overleaf)

The following serious symptoms may occur in rare cases. In such cases, immediately
seek medical aid.
Name of symptom

Symptom

Hepatic function failure

General malaise, jaundice (yellowing of skin and white ofeyes), etc., may occur.

3. When symptoms do not improve even after taking this medicine for 5 to 6 days,
stop taking this medicine and consult a physician, dentist, pharmacist or
registered salesperson, being sure to take this package insert (instructionleaflet) with you.
4. When a toothache does not cease even after taking this medicine once or twice,stop taking the medicine and consult a dentist. Be sure to take this package
insert (instruction leaflet) with you.

[Indications]
Soft stool, diarrhea, food poisoning, water poisoning, diarrhea andvomiting, loose bowels, diarrhea due to indigestion, and toothache[Dosage and Directions]
1. Take the following dosages with cold or warm water within 30 minutes
after a meal.
AgeAdults (15 years and older)11-14 years of age
8-10 years of age
5-7 years of age
Under 5 years of age

One dose
3 pills
2 pills
1.5 pills
1 pillDaily dose
3 times

Do not use

2. For toothache, apply 1/2-1 pills to fill the dental cavity.
[Dosage and Administration Precautions](1) Follow the dosage and directions.
(2) When allowing children 5 years old and over to take the medicine, a guardian must
be present, and caution must be exercised to prevent them from taking an incorrect
dose or choking on it.

[Ingredients and Contents]
Every 9 tablets (maximum daily adult dosage) include the following ingredients.

Active IngredientsContents

EffectJP wood creosote*Normalization of excessive colonic motility,
400 mg regulation of intestinal water content

JP powdered gambir
JP powderedphellodendron bark200 mg Improvement of intestinal motility
300 mg Improvement of gastric function,
bacteriostasis inside the intestines

JP powdered
glycyrrhiza

150 mg Repair of damaged gastric mucosa,detoxification

Powdered citrus unshiu peel

300 mg Improvement of gastric function[Inactive ingredients] Cinnamon, CMC-Ca, glycerin*There are two types of substances generally called “creosote”: one is JP wood-tar
creosote derived from beechwood trees, and the other is industrial creosote (coal-tarcreosote) extracted from coal. However, these substances are completely different interms of raw materials, components, and use. In addition, the results of carcinogenicity
tests have demonstrated that JP wood creosote is not identified as carcinogenic.
For more information or inquiries, please visit our website (http://www.seirogan.co.jp/)
or contact our customer service department.

[Storage and Handling Precautions]
1. Keep out of reach of children.
2. Do not transfer the medicine to a different container. (It may lead tomisuse or alter the quality of the drug.)
3. Store in a cool place away from direct sunlight and keep it tightly
closed.
4. Do not use after the use-by date indicated on the package.
Marketing authorization holder

3-34-14, Uchihonmachi, Suita Osaka, Japan 564-0032