Access multiple nuclei in one NMR spectrometer in a fully automatic way

Benefits of the Spinsolve Multi X• Instant switching between nuclei
without any loss in sensitivity

13

C and 31P measured in a Spinsolve Multi X13C

• No manual intervention required forswitching nuclei• Works with optional autosampler so
all available nuclei can be acquired
unattended• Interleave multinuclear experimentsfor online reaction monitoring• 1D and 2D experiments calibrated atfactory, switch back and forth without
recalibration• No training requirement for operator

31PExtensive software library of pre-calibrated protocols for all available nuclei
2D COSY

2D 31P-HMBCnuclei as they generate cross peaks out of the diagonal of thephosphorus atom at position 15. It can clearly be seen that

The 2D COSY experiment allows one to identify coupled 1H
2D data set.

1

H

H 2D COSY experiment of a 800 mM SPHOS sample in CDCl3
acquired on a Spinsolve Multi X 60 MHz system.
1

The long-range 1H-31P correlations can be observed for theboth couplings to the aromatic protons 1, 3, 5 and 6 (green)
as well as the aliphatic protons (blue) are present.

P-HMBC NMR spectrum of a 800 mM SPHOS sample in CDCl3
showing the long-range couplings between 1H and 31P nuclei.
31

2D HSQC-ME

2D HMBC

the 1H with the one-bond coupled 13C nuclei.

experiment shows the long-range correlation of protons 10The HSQC is a powerful sequence widely used to correlate

TheHeteronuclear

Multiple

BondCorrelation(HMBC)

and 11 with carbons 4, 7, 8, 9 and 12 (the sequence shows
the correlation with quaternary carbons, too).

HSQC-ME spectrum of a 800 mM SPHOS sample in CDCl3
showing the correlation between the 1H (horizontal) and 13C(vertical) signals.

HMBC spectrum of a 800 mM SPHOS sample in CDCl3 showing
the long-range couplings between 1H and 13C nuclei.

Spinsolve Multi X with 29Si for structural characterization
The strong dependency of 29Si chemical shift to the chemical environment makes silicon NMR a suitable tool todetermine the composition of polysiloxanes. The figure below shows the DEPT spectrum of poly(dimethylsiloxane-comethylhydrosiloxane), trimethylsilyl terminated, measured by setting the X channel of the Spinsolve to silicon. The result isin excellent agreement with the predicted chemical shifts of the single building blocks.

29

SiSpinsolve Multi X with optional PFG to measure molecular mobility
Pulsed field gradient (PFG) experiments are useful to asses the molecular mobility of different molecules dissolved in amixture. By adding a gradient coil to the Spinsolve Multi X you can measure the diffusion coefficient of molecules containing
any of the nuclei available on the spectrometer. The example below shows the 1H, 19F and 7Li PFG experiments measured
on a LiFSI:EmimFSI ionic liquid sample dissolved at a molar concentration of 2:3.

197FLiCBS reduction of acetophenone studied by 11B NMR
To demonstrate the power of 11B NMR we followed a typical CBS (Corey, Bakshi, Shibata) reduction reaction of acetophenone
to its corresponding alcohol by using both 11B and 13C measurements on a Spinsolve Multi X system. The CBS reduction

employs a boron containing catalyst (a), which is first activated with a borane solution in THF (b). The activated species (c)serves as the catalyst in the reduction of acetophenone. The final product (d) can nicely be observed in 11B NMR. The final
asymmetric alcohol is obtained after an acidic work up employing HCl in MeOH. These steps have been confirmed by 13C
NMR performed on the same spectrometer.

11a)

Bb)c)

d)

Spinsolve Multi X
� Nuclei: All models measure 1H and 19F
Optional X nuclei: 7Li, 11B, 13C, 15N, 29Si, 31P (inquire for other X nuclei)� Includes a powerful multi-line solvent suppression method
� Includes X-decoupled proton acquisition for all available X nuclei
� Exceptional Linewidth specifications for all models
The high homogeneity of the Spinsolve Multi X is possible due to advances in the patented shimming
technology used in the Magritek High Homogeneity Halbach Magnets**Patent US 8,148,988 and EP 2,144,076

Contact us now for a quote, to request a demo, or to measure your samples
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