October 23, 2020

Hiroyuki Kamiguchi, M.D., Ph.D.
Current Affiliation & Title
RIKEN Center for Brain Science
Acting Director
2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Education
1996

Ph.D., Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan1989

M.D., Keio University School of Medicine, Tokyo, Japan

Licensure & Certification
1995

Board Certified in Neurosurgery

1989

Licensed to Practice Medicine in Japan

Professional Training & Employment
2020-present

Acting Director, RIKEN Center for Brain Science

2018-2019

Deputy Director, RIKEN Center for Brain Science

2011-2017

Senior Team Leader, RIKEN Brain Science Institute2003-2011Team Leader, RIKEN Brain Science Institute1999-2002

Senior Scientist, RIKEN Brain Science Institute1996-1998

Research Associate with Prof. Vance Lemmon,
Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA

1995

Instructor, Department of Neurosurgery, Keio University

1994

Chief Resident, Department of Neurosurgery, Keio University

1992-1993

Senior Resident & Clinical Fellow, Department of Neurosurgery, Keio University

1991

Medical Staff in Neurosurgery, Urawa City Hospital, Japan

1990

Medical Staff in Neurosurgery, Saiseikai Utsunomiya Hospital, Japan

1989

Resident in Surgery, Keio University Hospital, Japan

Adjunctive Appointments
2020-2026

Member, Science Council of Japan (25th–26th terms)

2020-present

Coordinate Professor, Graduate School of Medicine, The University of Tokyo, Japan

2016-2018

Program Officer, Research Center for Science Systems,
Japan Society for the Promotion of Science (JSPS)

2007-2009

Visiting Professor, Waseda University Faculty of Science and Engineering, Japan

2004

Invited Lecturer, Chiba University Graduate School of Science & Technology, Japan

2004

Invited Professor, University of Louis Pasteur, Strasbourg, France
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Academic Society Activity
Executive Committee Chair, The 42nd Annual Meeting of the Japan Neuroscience Society (2019)
Faculty Member of F1000Prime Neuroscience (2017-present)
Editor-in-Chief of Neuroscience Research, the official journal of the Japan Neuroscience Society (2017-present)
Principal Investigator, Japan Agency for Medical Research and Development (AMED-CREST) (2016-21)
Chair of Selection Committee, Japan Neuroscience Society Young Investigator Award (2016-7)
Chair of Selection Committee, Tokizane Memorial Award for Excellent Graduate Study in Neuroscience (2017)
Selection Committee, Award for Distinguished Investigator of Japanese Society for Neurochemistry (2016-9)
Director of the Japan Neuroscience Society (2015-present)
Executive Committee Member, The 38th Annual Meeting of the Japan Neuroscience Society (2015)
Brain Science Dictionary Committee Member of the Japan Neuroscience Society (2014-9)
International Collaboration Affairs Committee of the Japan Neuroscience Society (2013-9)
International Brain Research Organization (IBRO) Asian/Pacific Regional Committee (2013-5)
Executive Committee Chair, The 36th Annual Meeting of the Japan Neuroscience Society (2013)
Director of the Japanese Society for Neural Growth, Regeneration and Transplantation (2008-12)
Chair of Organizing Committee, RIKEN Brain Science Institute Summer Program (2008)
Executive Committee Member, The 31st Annual Meeting of the Japan Neuroscience Society (2008)
Organizer, International Brain Research Organization (IBRO) Advanced School (2007)
Council Member of the Japan Society for Cell Biology (2006-10)
Council Member of the Japanese Society for Neurochemistry (2005-present)
Hydrocephalus Research Committee, The Ministry of Health, Labour and Welfare of Japan (1999-2004)
Academic Trustee of The Japan Neurosurgical Society (1995-present)Awards & Honors
Kitasato Award (2017)
The Japanese Society for Neurochemistry Young Scientists Lectureship Award (2004)
Medical School Alumni Award from Keio University (2002)
Award from the Japan Intractable Diseases Research Foundation (2001)

Editorial Board
Neuroscience Research (2014-present): Editor-in-Chief (2017-present)
Experimental Neurology (2009-20)
Neural Development (2008-present)

Selected Publications
Guy AT, Kamiguchi H: Lipids as new players in axon guidance and circuit development. Current Opinion inNeurobiology 66: 22-29, 2020
Chan C, Ooashi N, Akiyama H, Fukuda T, Inoue M, Matsu-Ura T, Shimogori T, Mikoshiba K, Kamiguchi H:Inositol 1,4,5-trisphosphate receptor type 3 regulates neuronal growth cone sensitivity to guidance signals.
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iScience 23: 100963, 2020
Wada F, Nakata A, Tatsu Y, Ooashi N, Fukuda T, Nabetani T, Kamiguchi H: Myosin Va and endoplasmic
reticulum calcium channel complex regulates membrane export during axon guidance. Cell Reports 15:1329-1344, 2016
Akiyama H, Fukuda T, Tojima T, Nikolaev VO, Kamiguchi H: Cyclic nucleotide control of microtubule
dynamics for axon guidance. Journal of Neuroscience 36: 5636-5649, 2016
Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, ItoY, Aoki J, Hirabayashi Y, Kamiguchi H: Glycerophospholipid regulation of modality-specific sensory axon
guidance in the spinal cord. Science 349: 974-977, 2015
Tojima T, Itofusa R, Kamiguchi H: Steering neuronal growth cones by shifting the imbalance between
exocytosis and endocytosis. Journal of Neuroscience 34: 7165-7178, 2014
Tojima T, Hines JH, Henley JR, Kamiguchi H: Second messengers and membrane trafficking direct andorganize growth cone steering. Nature Reviews Neuroscience 12: 191-203, 2011
Akiyama H, Kamiguchi H: Phosphatidylinositol 3-kinase facilitates microtubule-dependent membrane transport
for neuronal growth cone guidance. Journal of Biological Chemistry 285: 41740-41748, 2010
Tojima T, Itofusa R, Kamiguchi H: Asymmetric clathrin-mediated endocytosis drives repulsive growth coneguidance. Neuron 66: 370-377, 2010
Tamada A, Kawase T, Murakami F, Kamiguchi H: Autonomous right-screw rotation of growth cone filopodiadrives neurite turning. Journal of Cell Biology 188: 429-441, 2010
Akiyama H, Matsu-ura T, Mikoshiba K, Kamiguchi H: Control of neuronal growth cone navigation byasymmetric inositol 1,4,5-trisphosphate signals. Science Signaling 2: ra34, 2009
Tojima T, Itofusa R, Kamiguchi H: The nitric oxide-cGMP pathway controls the directional polarity of growthcone guidance via modulating cytosolic Ca2+ signals. Journal of Neuroscience 29: 7886-7897, 2009
Tojima T, Akiyama H, Itofusa R, Li Y, Katayama H, Miyawaki A, Kamiguchi H: Attractive axon guidance
involves asymmetric membrane transport and exocytosis in the growth cone. Nature Neuroscience 10: 58-66,
2007
Ooashi N, Futatsugi A, Yoshihara F, Mikoshiba K, Kamiguchi H: Cell adhesion molecules regulate
Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3. Journal of Cell Biology
170: 1159-1167, 2005

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Nishimura K, Yoshihara F, Tojima T, Ooashi N, Yoon W, Mikoshiba K, Bennett V, Kamiguchi H: L1-dependent
neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow. Journal of Cell
Biology 163: 1077-1088, 2003
Nishimura T, Fukata Y, Kato K, Yamaguchi T, Matsuura Y, Kamiguchi H, Kaibuchi K: CRMP-2 regulates
polarized Numb-mediated endocytosis for axon growth. Nature Cell Biology 5: 819-826, 2003
Nakai Y, Kamiguchi H: Migration of nerve growth cones requires detergent-resistant membranes in a spatiallydefined and substrate-dependent manner. Journal of Cell Biology 159: 1097-1108, 2002
Kamiguchi H, Yoshihara F: The role of endocytic L1 trafficking in polarized adhesion and migration of nerve
growth cones. Journal of Neuroscience 21: 9194-9203, 2001
Kamiguchi H, Lemmon V: IgCAMs: bidirectional signals underlying neurite growth. Current Opinion in CellBiology 12: 598-605, 2000
Kamiguchi H, Lemmon V: Recycling of the cell adhesion molecule L1 in axonal growth cones. Journal ofNeuroscience 20: 3676-3686, 2000
Kamiguchi H, Long KE, Pendergast M, Schaefer AW, Rapoport I, Kirchhausen T, Lemmon V: The neural celladhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.
Journal of Neuroscience 18: 5311-5321, 1998
Kamiguchi H, Lemmon V: A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal
required for sorting to the axonal growth cone. Journal of Neuroscience 18: 3749-3756, 1998
Kamiguchi H, Hlavin ML, Yamasaki M, Lemmon V: Adhesion molecules and inherited diseases of the humannervous system. Annual Review of Neuroscience 21: 97-125, 1998
In total, 84 articles in English and 30 articles in Japanese have been published.

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