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CAS No.: 1557267-42-1

Avitinib
Research Area: EGFR/BTK/Cancer• An irreversible, orally active and selective EGFR
inhibitor, with IC50s of 0.18 nM, 0.18 nM, and 7.68
nM for EGFR L858R, EGFR T790M, and wildtype EGFR, respectively.
• Shows potent inhibition of non-small cell lungcancer (NSCLC) that harbors EGFR-active andT790M mutations in xenograft mouse models.
• A BTK inhibitor that induces apoptosis andinhibits phosphorylation of BTK in mantle celllymphoma.
Solubility: DMSO : 125 mg/mL (256.39 mM; Need ultrasonic)

CAS No.: 1141768-04-8

PVZB1194Research Area: Kinesin/Eg5/Cancer• An ATP-competitive biphenyl-type Eg5 ATPase
inhibitor that binds to the α4/α6 allosteric pocket.
• Binds to the allosteric pocket and induces thedeformation of the ATP-binding pocket throughthe Tyr104 residue.
• Inhibits HeLa cell proliferation, enhances thestability of microtubules, and exhibits anticancer
potential.
Solubility: DMSO : 250 mg/mL (783.04 mM; Need ultrasonic)

CAS No.: 2408840-26-4

Imlunestrant
Research Area: Estrogen Receptor/Breast Cancer• A selective and orally active wild-type and mutant
estrogen receptor degrader (SERD) with pureantagonistic properties.
• Potently inhibits wild-type ERα andY537S/Y537N mutant ERα proteins.
• Used for the research in breast cancer andendometroid endometrial cancer.
Solubility: DMSO : 250 mg/mL (476.64 mM; Need ultrasonic)

CAS No.: 903886-95-3

A-908292
Research Area: Acetyl-CoA Carboxylase/ACC2/Metabolic Disease• A selective acetyl-CoA carboxylase 2 (ACC2)
inhibitor with an IC50 value of 38 nM.
• Reduces serum glucose and triglyceride levels inob/ob mice.
• Used in the research of lipidemia.

Solubility: DMSO : 50 mg/mL (138.72 mM; ultrasonic and warming and heat to 60°C)

CAS No.: 127-33-3

Demeclocycline
Research Area: Antibiotic/Infection• An orally active tetracycline antibiotic against avariety of bacterial infections.
• Impairs protein synthesis by binding to the 30S
ribosomal subunit to inhibit binding of aminoacyltRNA.
• Used for the research in syndrome ofinappropriate antidiuretic hormone secretion(SIADH).
Solubility: DMSO : 25 mg/mL (53.78 mM; Need ultrasonic)

Highly Selective Inhibitors Library
According to reports, most known kinase inhibitors exert their effects throughcompetitive binding in highly conserved ATP pockets. Although genetic
techniques such as RNA interference can inactivate specific genes, mostkinases are multi domain proteins, each of which has an independent function.
Highly selective inhibitors have higher efficiency than non-selective inhibitors,
and the selectivity to the target is at least 100 times higher. Therefore,ensuring the validation of targets with the most selective inhibitors is crucial fora more thorough understanding of the pharmacology of the kinase field. The
Highly Selective Inhibitors Library contains 4,000+ compounds, covering
multiple targets and subtypes, such as GPCR protein family, Ion channel,
multiple kinases, etc. The Highly Selective Inhibitors Library is an effective toolfor screening different phenotypes.

CS Isotope-labeled Compounds
Cat. No.

Product Name

CS-0371138

Puromycin-d3StructureCS-0202868

Propranolol-d7

CS-0635908

Dosimertinib-d5 mesylate

CS-0200471

9-cis-Retinoic acid-d5

Latest Publications Citing Use of CS Products
Cell.
2023 Jun 22;186(13):2748-2764.e22.
Cell.
2023 Jul 6;186(14):3013-3032.e22.
Cancer Cell.
2023 Jul 10;41(7):1345-1362.e9.
Cancer Cell.
2023 Jul 10;41(7):1242-1260.e6.

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