臨床病態解析学講座【研究プロジェクト名および概要】
I. がんの病態解析と新規診断・治療法の開発
1.

転移・再発におけるクローン選択とその分子基盤の解明

2.

ゲノム不安定の獲得機構とその制御法の解析

3.

Tumor cell dormancy の分子機構の解明

4.

RNA 修飾を介した腫瘍発症・進展機構の解析

II．非侵襲的心機能評価の研究
1.

超音波検査の新たな解析手法を用いた弁膜症評価に関する研究

2.

非侵襲的検査を用いた心筋虚血の検出に関する研究

3.

超音波検査を用いた心機能評価に関する研究

III．臨床検査に根付いた研究開発
1. 凝固関連遺伝子の遺伝学的検査と、凝固因子活性値測定手法の開発
IV.

熊本県心血管エコー検査標準化プロジェクト
1. アンケート調査による熊本県の心血管エコー検査の現状評価
2. 臨床検査技師・医師間の技術レベル均てん化の試み【教職員および大学院学生】【メールアドレス】

教 授（併任） 田中 靖人
ytanaka@kumamoto-u.ac.jp
准 教 授
神力 悟
satorus@kumamoto-u.ac.jp
助教宇宿 弘輝（中央検査部）
h-usuku@kumamoto-u.ac.jp
大学院生
Shiyang Deng
（博士課程）
技術補佐員
東 亜弥【連絡先】 電話/FAX: 096-373-5283【特殊技術・特殊装置】
1. アンプリコンシーケンス
2. mRNA シーケンス
3. ChIP シーケンス
4. リボソームプロファイリング
5. リアルタイム PCR
6. DNA シーケンサー
7. 経胸壁・経食道心エコー (2D, 3D)【研究プロジェクト】
研究総括
I, III, 研究総括
II, IVII【ホームページ】 http://www2.kuh.kumamoto-u.ac.jp/Mol_Lab_Med/

8. 血管エコー
9. 運動負荷心電図
10. 24 時間 Holter ECG

【英文原著】
1.

Adachi T, Goda H, Shinriki S, Tokuzen N, Kuribayashi N, Hino S, Nakashiro K, Uchida D. Prognostic significanceof serum Interleukin-6 levels in oral squamous cell carcinoma. Cureus. 16:e54439, 2024.

2.

Tierens A, Kagotho E, Shinriki S, Seto A, Smith A, Care M, Maze D, Sibai H, Yee K, Schuh A, Kim D, Gupta V,Minden MD, Matsui H, Jose-Mario C. Biallelic disruption of DDX41 activity is associated with distinct genomic andimmunophenotypic hallmarks in acute leukemia. Front Oncol. 13:1153082, 2023.

3.

Tungalag S, Shinriki S, Hirayama M, Nagamachi A, Kanai A, Inaba T, Matsui H. Ribosome profiling analysis reveals
the roles of DDX41 in translational regulation. Int J Hematol. 117:876-888, 2023.

4.

Hirayama M, Shinriki S, Matsui H. R-loops in normal and malignant hematopoiesis. Front Hematol. 2: 1297657,2023.

5.

Sumi H, Hoshiyama T, Morihisa K, Noda K, Kaneko S, Kanazawa H, Ishii M, Fujisue K, Sueta D, Takashio S, Usuku
H, Matsushita K, Tsujita K. Effect of contact vector direction on achieving cavotricuspid isthmus block. Sci Rep.
13(1):2579, 2023.

6.

Usuku H, Yamamoto E, Sueta D, Shinriki R, Oike F, Tabata N, Ishii M, Hanatani S, Hoshiyama T, Kanazawa H,Arima Y, Takashio S, Kawano Y, Oda S, Kawano H, Ueda M, Tsujita K. A New Staging System Using Right Atrial
Strain in Patients with Immunoglobulin Light-Chain Cardiac Amyloidosis. ESC Heart Fail. doi: 10.1002/ehf2.14710.

7.

Takashio S, Morioka M, Ishii M, Morikawa K, Hirakawa K, Hanatani S, Oike F, Usuku H, Kidoh M, Oda S,Yamamoto E, Matsushita K, Ueda M, Tsujita K. Clinical characteristics, outcome, and therapeutic effect of tafamidis
in wild-type transthyretin amyloid cardiomyopathy. ESC Heart Fail. 10(4):2319-2329, 2023.

8.

Sumi H, Hoshiyama T, Morihisa K, Noda K, Kaneko S, Kanazawa H, Ishii M, Fujisue K, Sueta D, Takashio S, Usuku
H, Matsushita K, Tsujita K. Effect of contact vector direction on achieving cavotricuspid isthmus block. Sci Rep.
13(1):2579, 2023.

9.

Miyazaki S, Fujisue K, Yamanaga K, Sueta D, Usuku H, Tabata N, Ishii M, Hanatani S, Hoshiyama T, Kanazawa H,Takashio S, Arima Y, Araki S, Yamamoto E, Matsushita K, Tsujita K. Prognostic Significance of Soluble PD-L1 on
Cardiovascular Outcomes in Patients with Coronary Artery Disease. J Atheroscler Thromb. Doi: 10.5551/jat.64183
2023.

10. Usuku H, Yamamoto E, Sueta D, Imamura K, Oike F, Marume K, Hanatani S, Arima Y, Takashio S, Oda S, Kawano
H, Ueda M, Matsui H, Tsujita K. Usefulness of automatic assessment for longitudinal strain to diagnose wild-typetransthyretin amyloid cardiomyopathy. Int J Cardiol Heart Vasc. 22;47:101227, 2023.
11. Amaki M, Moriwaki K, Nakai M, Yamano T, Okada A, Kanzaki H, Izumo M, Usuku H, Onishi T, Nagai T, Miyamoto
Y, Fujita T, Kawai H, Akashi Y, Tsujita K, Matoba S, Kobayashi J, Izumi C, Anzai T. Cost-effective analysis oftranscatheter aortic valve replacement in patients with severe symptomatic aortic stenosis: A prospective multicenter
study. J Cardiol. 83(3):169-176, 2023.
12. Yamaguchi S, Oda S, Kidoh M, Hayashi H, Takashio S, Usuku H, Nagayama Y, Nakaura T, Tsujita K, Hirai T, Aoki
T. Cardiac MRI T1 and T2 Mapping as a Quantitative Imaging Biomarker in Transthyretin Amyloid Cardiomyopathy.
Acad Radiol. 31(2):514-522, 2023.
13. Usuku H, Yamamoto E, Sueta D, Noguchi M, Fujisaki T, Egashira K, Oike F, Fujisue K, Hanatani S, Arima Y,
Takashio S, Kawano Y, Oda S, Kawano H, Matsushita K, Ueda M, Matsui H, Matsuoka M, Tsujita K. Prognostic
value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis.
Eur Heart J Open. 3(3):oead048, 2023.
14. Matsushita K, Kojima S, Hirakawa K, Tabata N, Ito M, Yamanaga K, Fujisue K, Hoshiyama T, Hanatani S, Sueta D,Kanazawa H, Takashio S, Arima Y, Araki S, Usuku H, Suzuki S, Yamamoto E, Nakamura T, Soejima H, Kaikita K,Tsujita K. Prognostic impact of diabetes mellitus on in-hospital mortality in patients with acute myocardial infarction

complicating renal dysfunction according to age and sex. Hellenic J Cardiol. S1109-9666(23)00221-X, 2023.
15. Matsushita K, Kojima S, Hirakawa K, Tabata N, Ito M, Yamanaga K, Fujisue K, Hoshiyama T, Hanatani S, Sueta D,Kanazawa H, Takashio S, Arima Y, Araki S, Usuku H, Suzuki S, Yamamoto E, Nakamura T, Soejima H, Kaikita K,Tsujita K. Differential effects of overweight/obesity depending on the severity of heart failure complicating acute
myocardial infarction in Japan. Prog Cardiovasc Dis. 78:49-57, 2023.
16. Nakanishi N, Kaikita K, Ishii M, Kuyama N, Tabata N, Ito M, Yamanaga K, Fujisue K, Hoshiyama T, Kanazawa H,Hanatani S, Sueta D, Takashio S, Arima Y, Araki S, Usuku H, Nakamura T, Yamamoto E, Soejima H, Matsuhista K,Tsujita K. Japanese high bleeding risk criteria status predicts low thrombogenicity and bleeding events in patients
undergoing percutaneous coronary intervention. Cardiovasc Interv Ther. 38(3):299-308, 2023.
17. Hayashi H, Oda S, Kidoh M, Yamaguchi S, Yoshimura F, Takashio S, Usuku H, Nagayama Y, Nakamura T, Ueda M,Tsujita K, Hirai T. Myocardial extracellular volume quantification in cardiac amyloidosis: a comparative study
between cardiac computed tomography and magnetic resonance imaging. Eur Radiol. 34(2):1016-1025, 2023.
18. Kawahara Y, Kanazawa H, Takashio S, Tsuruta Y, Sumi H, Kiyama T, Kaneko S, Ito M, Hoshiyama T, Hirakawa K,Ishii M, Tabata N, Yamanaga K, Fujisue K, Hanatani S, Sueta D, Arima Y, Araki S, Usuku H, Nakamura T, YamamotoE, Soejima H, Matsuhista K, Kawano H, Tsujita K. Clinical, electrocardiographic, and echocardiographic parameters
associated with the development of pacing and implantable cardioverter-defibrillator indication in patients withtransthyretin amyloid cardiomyopathy. Europace. 25(5):euad105, 2023.
19. Shinriki S, Hirayama M, Nagamachi A, Yokoyama A, Kawamura T, Kanai A, Kawai H, Iwakiri J, Liu R, Maeshiro
M, Tungalag S, Tasaki M, Ueda M, Tomizawa K, Kataoka N, Ideue T, Suzuki Y, Asai K, Tani T, Inaba T, Matsui H.
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic
cells. Leukemia 236(11): 2605-2620, 2022.