ポスター

Poster

1 日目（9 月 15 日（土））／Day 1（Sep. 15 Sat.）PA 会場（大集会室），PB 会場（南第二集会室），PC 会場（南第三集会室），PD 会場（南第四集会室） ／Room PA (Large Assembly Room), Room PB (2nd South Assembly Room),
Room PC (3rd South Assembly Room), Room PD (4th South Assembly Room)
蛋白質：構造／Protein: Structure
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分子動力学法を用いた Hras-GTP/GDP 複合体の各部の構造変化と各部の水素結合との動的関連性の研究
Molecular dynamics study of dynamical relationship between structures and the hydrogenbonds of some parts in the Hras-GTP/GDP complexes
Takeshi Miyakawa1, Ryota Morikawa1, Masako Takasu1, Kimikazu Sugimori2, Kazutomo Kawaguchi3,
Hidemi Nagao3 (1Sch. of Life Sci, Tokyo Univ. of Pharm. and Life Sci., 2Inst. of Liberal Arts. and Sci.,
Kanazawa Univ., 3Coll. of Sci. and Eng., Kanazawa Univ.)
分子シミュレーションを用いた複数ドッキングポーズからの正しい結合ポーズの特定―自動デザインに向けてIdentifying correct ligand binding pose out of multiple docking poses by MD simulations toward
AutoDesign
Hironori Kokubo (Axcelead, Inc.)α シヌクレインフラグメントの 2 量体形成過程の解明に向けた定温定圧レプリカ置換分子動力学
シミュレーション
Isothermal-isobaric replica-permutation molecular dynamics simulation to reveal dimerization
process of α-synuclein fragments
Masataka Yamauchi1,2,3, Hisashi Okumura1,2,3 (1SOKENDAI, 2IMS, 3ExCELLS)
Cryo-tomography and sub-tomogram averaging of dimeric F type ATP synthase at bovine submitochondrial particle
Jun-chi Kishikawa1, Atsuko Nakanishi1, Masatoshi Murai2, Kaoru Mitsuoka3, Ken Yokoyama1 (1Dept.
Mol. BioSci., Kyoto Sangyo Univ., 2Div. Appl. Life Sci., Grad. Sch. Agrci., Kyoto Univ., 3Res. Ctr. UHVEM,
Osaka Univ.)
クライオ電子顕微鏡による好熱菌 Thermus thermophilus 由来 V 型 ATP 合成酵素の単粒子解析
Cryo EM structure of intact rotary H+-ATPase/synthase from Thermus thermophilus
Atsuko Nakanishi1, Jun-ichi Kishikawa1, Masatada Tamakoshi2, Kaoru Mitsuoka3, Ken Yokoyama1(1Dept. of Mol. Biosci., Kyoto Sangyo Univ., 2Dept. of Mol. Biol., Tokyo Univ. of Pharm. and Life Sci., 3Res.
Ctr. for UHVEM, Osaka Univ.)
Startup of Laboratory-scale SEC-SAXS (La-SSS) system
Rintaro Inoue, Ken Morishima, Nobuhiro Sato, Masaaki Sugiyama (Institute for Integrated Radiation and
Nuclear Science, Kyoto UniversityInstitute for Integrated Radiation and Nuclear Science, Kyoto University)
Determination and Comparsion of the Structural Ensemble of Molten Globule State of Proteinsby Computer Simulations
Masahiro Shimizu, Yuko Okamoto (Grad. Sch. Sci., Univ. Nagoya)
GPI アタッチメントシグナルの二次構造解析
Secondary structural analysis of GPI attachment signal
Keiya Inoue1, Daiki Takahashi1, Tatsuki Kikegawa1, Kenji Etchuya2, Yuri Mukai1 (1Dept. Electronics,
Grad. Sch. Sci. & Tech., Meiji Univ., 2Biomed. Res. Inst., AIST)
位相差クライオ電子顕微鏡単粒子解析法を用いた腸球菌 V-ATPase の構造解析
Single Particle Analysis of EhV-ATPase by Phase-Plate electron cryo-microscopy
Jun Tsunoda1,2, Chihong Song2, Fabiana Lica Yakushiji3, Takeshi Murata3, Hiroshi Ueno4,
Naoyuki Miyazaki5, Kenji Iwasaki5, Junichi Takagi5, Ryota Iino1,6, Kazuyoshi Murata1,2 (1SOKENDAI,
2NIPS, 3Dept.Chem., Chiba Univ., 4Dept. Appl. Chem., Sch. Eng., Univ. Tokyo, 5IPR, Osaka Univ., 6IMS)– S129 –1Pos010

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マルチスケールシミュレーションと構造比較を用いた、シグナル蛋白質カルモジュリンの研究
Multiscale simulation and Structural comparison of Calmodulin
Hiromitsu Shimoyama (Kitasato University)
Investigation of the common sequence-structural patterns in different protein folds using crossprofile analysis and simulation
Yu Yamamori, Kentaro Tomii (AIST)
Modeling three-dimensional (3D) volume of protein from Atomic-Force Microscopy (AFM)
imagesBhaskar Dasgupta1, Osamu Miyashita2, Florence Tama1,2,3 (1Department of Physics, Graduate School of
Science, Nagoya University, 2Center for Computational Science, RIKEN, Kobe., 3Institute ofTransformative Bio-Molecules (WPI-ITbM), Nagoya University)
結合ヌクレオチド依存的なチューブリン C 末端テイルの構造分布に関する分子動力学計算解析
The bound-nucleotide (GDP or GTP) effects on C-terminal tails of tubulins investigated bymolecular dynamics simulation
Takuma Todoroki1, Yukinobu Mizuhara2, Jun Ohnuki2, Mitsunori Takano2, Koji Umezawa1,3 (1Grad. Sch.
of Sci. & Tech., Shinshu Univ., 2Grad. Scl. of Adv. Sci. & Eng., Waseda Univ., 3IBS, Shinshu Univ.)
クライオ電子顕微鏡によるグルタミン酸脱水素酵素ドメイン運動の可視化
Visualizing the domain motion of Glutamate Dehydrogenase by using cryo-electron microscopy
Mao Oide1,2, Takayuki Kato3, Tomotaka Oroguchi1,2, Keiichi Namba3,4, Masayoshi Nakasako1,2 (1Grad.
Sci. Tech., Keio Univ., 2RIKEN SPring-8 center, 3Grad. Sch. of Front. Biosci., Osaka Univ., 4RIKEN,
QBiC)
クライオ電子顕微鏡単粒子解析法を用いた KcsA の構造解析
Structural Analysis of KcsA by Cryo-EM Single Particle Analysis
Hiroko Takazaki1, Hirofumi Shimizu2, Kaoru Mitsuoka3, Takuo Yasunaga1 (1Grad. Sch. Comp. Sci. Syst.
Eng., KIT, 2Fac. Med. Sci., Univ. Fukui, 3Research Center for UHVEM, Univ. Osaka)Porphyromonas gingivitis の線毛蛋白質 FimA の構造
Structure of FimA, a major component protein of fimbriae of Porphyromonas gingivitis
Kodai Okada1, Koji Nakayama2, Mikio Shoji2, Satoshi Shibata3, Katsumi Imada1 (1Grad. Sch. Sci., Osaka
Univ., 2Grad. Sch. Biomedical Sci., Nagasaki Univ., 3OIST)
好熱菌 V1-ATPase の単粒子解析
Single particle analysis of V1-ATPase from Thermus thermophilus
Aya Furuta1 (1Division of Life Sciences, Kyoto Sangyo University, Kyoto (Japan), 2Research Center for
Ultra-High Voltage Electron Microscopy, Osaka University, Osaka (Japan))
マベガイ由来 PPL3 の構造解析
Structure analysis of PPL3 regulating pearl shell biomineralization
Setsu Nakae1, Masafumi Shionyu1, Tomohisa Ogawa2, Tsuyoshi Shirai1 (1Fac. Bio-Sci., Nagahama Inst.
Bio-Sci. Tech., 2Grad. Sch. Life Sci., Tohoku Univ.)
Application of the solution technique to identify a binding site and mode of a ligand in a protein
Masataka Hamano, Masatake Sugita, Takeshi Kikuchi, Fumio Hirata (Dept. Bioinf. Col. Life Sci.
Ritsumeikan Univ.)
MM/3D ー RISM 法を用いた水・エタノール混合溶液中における小分子間における結合エネルギー予測
Cosolvent effect on the binding affinity between small molecules in a water-ethanol mixture :MM/3D-RISM study
Kazuma Kondo1, Masatake Sugita1, Takeshi Kikuchi1, Fumio Hirata2 (1Dept. of Bioinf., Col. Life Sci.,
Ritsumeikan Univ.,, 2Toyota Phys. & Chem. Res. Inst.)
MD シミュレーションを用いた BAF の野生型と変異体の揺らぎの解析
Analyses of fluctuations of wild type and mutant of BAF using MD simulation
Chiaki Yamaguchi1, Siyao Li2, Masatake Sugita1, Toshiya Hayano2, Takeshi Kikuchi1 (1Dept. of Bioinf.,
Col. Life Sci., Ritsumeikan Univ., 2Dept. of Biomed., Col. Life Sci., Ritsumeikan Univ.)– S130 –1Pos022

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Bio-SAXS を活用したタンパク質相関構造解析
Hybrid Approach of the Protein Structure Analysis utilizing Biological Small-Angle X-ray
Scattering
Kento Yonezawa, Keiko Yatabe, Masatsuyo Takahashi, Yasuko Nagatani, Nobutaka Shimizu (Photon
Factory, IMSS, KEK)
Chk1 阻害剤系の分類と自由エネルギー変分原理に基づく相対的結合自由エネルギー予測
Classification of Chk1 inhibitor system and Prediction of relative binding free energy based on afree energy variational principal
Daichi Kondo, Takeshi Ashida, Takeshi Kikuchi (Dept. Bioinf. Col. Life Sci. Ritsumeikan Univ.)
Sensitivity to radiation dose of buried waters in Green Fluorescent Protein
Hoang Anh Dao, Kiyofumi Takaba, Yang Tai, Nagayuki Hasegawa, Kazuki Takeda (Kyoto University
Graduate School of Science)
ジスルフィド結合は β-ストランドを逆平行に会合することに関与している？
Do disulfide bonds involve in β-strand assembly in anti-parallel manner ?
Hiromi Suzuki (Sch. Agri., Meiji Univ.)
単粒子コヒーレント回折パターンを用いた粗視化分子モデリングのためのテンプレートマッチン
グ法
A template matching method for coarse-grained molecular modelling using a noisy single
particle coherent diffraction pattern
Atsushi Tokuhisa1,5, Ryo Kanada1, Shuntaro Chiba2, Yuta Isaka3, Biao Ma3, Shigeyuki Matsumoto2,
Kei Terayama4,6, Narutoshi Kamiya7, Yasushi Okuno1,2,3,4 (1RIKEN. RCSTI. RCH, 2RIKEN. RCSTI. MIH,
3FBRI. CCD, 4Grad. Sch. Med., Univ. Kyoto, 5RIKEN. R-CCS, 6RIKEN. AIP, 7Grad. Sch. Sim., Univ.
Hyogo)
テンプレートの MD シミュレーションを利用したタンパク質モデリングツールの開発
Development of Template-based Protein Structure Modeling Software using Molecular
Dynamics Simulations of Template proteins
Masaya Furue, Naoyuki Miyashita, Mitsutaka Nemoto (BOST, KINDAI Univ.)
Hsp90 をターゲットとするペプチドアプタマーの構造と、シミュレーションのための力場作成支援プログラムの開発
Dynamics of peptide aptamer which targeting Hsp90 and the development of supporting
program for modification of force field parameters
Lisa Matsukura1, Kazuto Mochizuki2, Masumi Taki2, Naoyuki Miyashita1, Shinichi Watanabe2 (1BOST,KINDAI Univ., 2GSIE, UEC.)
A skewed distribution of psi-loop motifs in the protein structure database
Koki Fukuda, George Chikenji (Dept. Appl. Phys. ,Grad. Sch. Eng. , Nagoya Univ.)
The protein structure database analysis of the greek key motif and its similar structures
Ryuichiro Ueda, George Chikenji (Dept. Appl. Phys. , Grad. Sch. Eng. , Nagoya Univ.)
Observation of the dynamics associated with ubiquitination of HECT E3 ubiquitin ligase using
High speed AFM
Ikumi Muro1, Huminori Kobayashi1, Takahiro Nakayama2, Noriyuki Kodera2, Toshio Ando2,
Hiroki Konno2 (1Graduate School of Natural Science & Technology, Kanazawa University, 2Nano life
science institute, Kanazawa University)
転写制御因子 LmrR および QacR における多剤認識メカニズムに関する分子シミュレーション研究
Molecular simulation study of the underlying mechanism of multidrug recognition intranscriptional regulators LmrR and QacR
Kazuho Cryershinozuka, Tadaomi Furuta, Minoru Sakurai (Center for Biol. Res. & Inform., Tokyo Tech)
Attempts at CA-type formal analysis of fibrous assembly of particles
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ファーマコフォア解析を用いたビタミン D 受容体のアゴニスト/アンタゴニスト活性調節機構の研究
Regulation mechanism of agonistic / antagonistic activities of vitamin D receptor studied bypharmacophore analysis
Takafumi Kudo, Toru Ekimoto, Mitsunori Ikeguchi (Grad. Sch. Medical Life Sci., Yokohama City Univ.)
基準振動のネットワーク解析による TCR-pMHC 複合体の動的構造
Dynamic structures of TCR-pMHC complexes studied by a network analysis of normal modes
Hiroshi Wako1, Yuko Tsuchiya2, Shigeru Endo3 (1Sch. of Soc. Sci., Waseda Univ., 2AIRC, AIST, 3Sch. ofSci., Kitasato Univ.)
蛋白質：構造機能相関／Protein: Structure & Function

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サルモネラ菌べん毛タンパク質 FliC と FljB で構成された繊維構造の比較と機能の違い
Structural comparison between Salmonella flagellar filaments consisting of FliC and FljB and
the implication for their functions
Tomoko Yamaguchi1, Takayuki Kato1, Naoya Terahara1, Shoko Toma1, Keiichi Namba1,2 (1Osaka
University FBS, 2BDR & SPRING-8, RIKEN)
溶液 NMR 法を用いた MAPK p38α によるストレスシグナル伝達最適化の構造機構の解明
Structural Basis for the Optimum Stress Signal Transduction via MAPK p38α under the ATPdepleted, Low pH Condition Elucidated by NMR
Yuji Tokunaga1,2, Koh Takeuchi1, Hideo Takahashi3, Ichio Shimada1,4 (1molprof, AIST, 2JBIC, 3Grad Sch
Med Life Sci, YCU, 4Grad Sch Pharm Sci, UTokyo)
自由エネルギー地形による T686A 変異 AMPA 受容体の部分作動メカニズムの解明
Free-energy landscapes reveal partial agonism at T686A mutation of AMPA receptor
Hiraku Oshima1, Suyong Re1, Masayoshi Sakakura2, Hideo Takahashi2, Yuji Sugita1 (1RIKEN BDR,
2Grad. Sch. of Med. Life Sci., Yokohama City Univ.)
糖転移酵素の基質特異性メカニズムの解明
Clarify of the substrate specificity mechanism of glycosyltransferase
Go Miyasaka1, Kenji Etchuya2, Yuri Mukai1 (1Dept. Electronics, Grad. Sch. Sci. & Tech., Meiji Univ.,
2Biomed. Res. Inst., AIST)
Pin1 由来のタンパク質分解酵素の触媒部位の変異解析
Mutational analysis on the catalytic site of a protease derived from Pin1
Teikichi Ikura, Nobutoshi Ito (Med. Res. Inst., Tokyo Med. Dent. Univ.)
酵素 PHBH の 2 つの没食子酸産生変異体の違いについての理論的考察
Theoretical insight into differences in two PHBH mutants that can produce gallic acid
Yoshitaka Moriwaki1, Mirai Yato1, Tohru Terada2, Takatoshi Arakawa1, Shinya Fushinobu1,
Kentaro Shimizu1 (1Dept. of Biotechnol., Grad. Sch. of Agri. and Life Sci., 2Interfaculty Initiative inInformation Studies)
LysW・LysY・LysZ 三者複合体仮説のモデリング
Modeling of a hypothetical ternary complex of LysW, LysY, and LysZ
Ryo Shimura1, Yoshitaka Moriwaki1, Tohru Terada1,2, Takeo Tomita1, Makoto Nishiyama1,
Kentaro Shimizu1 (1Dept. of Biotechnol., Grad. Sch. of Agri. and Life Sci., Univ. of Tokyo, 2Interfaculty
Initiative in Information Studies)
How Toll-like receptor 4 dimerization is activated in lipid raft studied by molecular simulations
Manami Ikeda, Shyouzi Takada (Dept. of Biophys., Div. of Bio. Sci., Grad. Sch. of Sci., Univ. of Kyoto)
全反射赤外分光法による電位依存性タンパク質の構造研究
The chemistry-induced structural changes in voltage-sensing proteins studied by ATR-FTIR
Masayo Iwaki1, Hirotaka Narita1,2, Kohei Takeshita2, Yasushi Okamura3, Atsushi Nakagawa2,
Hideki Kandori1 (1Nagoya Inst. Tech., 2Inst. Protein Res., Osaka Univ., 3Grad. Sch. Med., Osaka Univ.)– S132 –1Pos045

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タンパク質の局所構造のサンプリングと構造コンプライアンス特性の解析
Sampling of Localized Structures of Proteins and Analysis of their Structural Compliance
Properties
Keisuke Arikawa (Fcl. Eng., Kanagawa Inst. of Tech.)
実験と計算で明らかにした β-1,2-グルコオリゴ糖結合タンパク質の構造機能相関
Structure-function relationships of β-1,2-glucooligosaccharide-binding protein revealed byexperimental and computational methods
Koichi Abe1, Naoki Sunagawa1, Tohru Terada2, Takatoshi Arakawa1, Kiyohiko Igarashi1,
Masahiro Samejima1, Hiroyuki Nakai3, Hayao Taguchi4, Masahiro Nakajima4, Shinya Fushinobu1 (1Grad.
Sch. Agric. Life Sci., Univ. Tokyo, 2GSII, Univ. Tokyo, 3Grad. Sch. Sci. Technol., Niigata Univ., 4Dept.
Appl. Bio. Sci., TUS)
Wide-angle x-ray scattering study on cyanobacterial circadian clock system
Shuji Akiyama1,2,3, Yoshihiko Furuike1,2,3, Atsushi Mukaiyama1,2,3, Takaaki Hikima3 (1CIMoS, IMS,NINS, 2SOKENDAI, 3RIKEN SPring-8 Center)
Minimum free energy path of the conformational change in multidrug ABC transporter
Ryuji Ishida1, Kei Moritsugu1, Hiroaki Kato2, Akinori Kidera1 (1Department of Medical Life Science,
Yokohama City University, 2Graduate School of Pharmaceutical Sciences, Kyoto University)
シクロスポリン A の CHARMM 力場の開発
Development of the CHARMM force field for Cyclosporine A
Tsutomu Yamane, Yuta Watanabe, Toru Ekimoto, Mitsunori Ikeguchi (Graduate School of Medical Life
Science, Yokohama City University)
Evaluation of tau’s effects on flexural rigidity and growth rate of microtubule under nanometerlevel precision
Hang Zhou1, Naoto Isozaki1, Taviare L. Hawkins2, Jennifer L. Ross3, Ryuji Yokokawa1 (1Kyoto
University, 2University of Wisconsin La Crosse, 3University of Massachusetts Amherst)
4-ヒドロキシイソロイシン脱水素酵素（ＨＩＬＤＨ）変異体における特異的反応に関する計算化学的研究
Computational investigation of the selective reaction in the 4-hydroxyisoleucine dehydrogenase(HILDH) mutant
Takaaki Sato1, Yoshitaka Moriwaki1, Tohru Terada1,2, Kentaro Shimizu1 (1Dept. of Biotechnol., Grad.
Sch. of Agri. and Life Sci., Univ. of Tokyo, 2Interfaculty Initiative in Information Studies, Univ. of Tokyo)
重水素化支援中性子小角散乱と超遠心分析を協奏的に用いた αB-クリスタリンの構造と動態
Structure and kinetics of αB-crystallin by complementary use of deuteration-assisted SANS and
AUC
Ken Morishima, Yusuke Sakamaki, Rintaro Inoue, Nobuhiro Sato, Masaaki Sugiyama (Institute forIntegrated Radiation and Nuclear Science)
タンパク質ダイナミクスに対する多様体学習の適用
Applications of a manifold learning technique to protein dynamics
Hiroto Kikuchi, Hiroshi Fujisaki (Dept. of Phys. Nippon Med. Sch.)
培養細胞に一過性発現されたヒトヘアケラチン K85 と K35 の中間径フィラメント形成
Intermediate filament assembly of transiently expressed human hair keratins K85 and K35 in
cultured cells
Yasuko Sakamoto1, Masaki Yamamoto1, Yuko Honda2, Kenzo Koike3, Toshihiko Matsumoto1,
Shoji Ando1 (1Sojo Univ. Fac. Biotech. Life Sci., 2Saga Univ. Fac. Med., 3Kao Corp.)
ヤナギマツタケ（Agrocybe cylindracea）の子実体特異的蛋白質 PRI4 の免疫組織化学と分子物性
Immunohistochemistry and molecular property of a fruiting body-specific protein, PRI4, of thebasidiomycete Agrocybe cylindracea
Mitsuki Hashimoto1, Chika Abematsu1, Masayuki Ikeda1, Masashi Shin1, Makoto Iwata2,
Toshihiko Matsumoto1, Shoji Ando1 (1Sojo Univ. Fac. Biotech. Life Sci., 2IMB)– S133 –1Pos056

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Crystal structure of human oxidative nucleotide hydrolase in complex with a newly foundsubstrate
Kana Fujimiya1, Teruya Nakamura1,2,3, Yuta Suzuki1, Shaimaa Waz2, Keisuke Hirata2, Mami Chirifu2,
Shinji Ikemizu1,2, Yuriko Yamagata1,2 (1Sch. of Pharmacy, Kumamoto Univ., 2Grad. Sch. of Pharmaceut.
Sci., Kumamoto Univ., 3Priority Organization for Innovation and Excellence, Kumamoto Univ.)
細菌 9 型分泌装置蛋白質 PorM の構造
Structure of PorM, a core component of bacterial type IX secretion system
Keiko Sato1, Kodai Okada2, Daisuke Nakane3, Koji Nakayama1, Katsumi Imada2 (1Grad. Sch. Biomedical
Sci., Nagasaki Univ., 2Grad. Sch. Sci. Osaka Univ., 3Dept. Phy. Gakushuin Univ.)
高速 AFM による IV 型線毛 ATPase-PilB の観察
Observation of the type IV pilus assembly ATPase PilB by using High-Speed AFM
Shogo Sugiyama1, Zhaomin Yang2, Takayuki Uchihashi3 (1Dept. of Phys., Kanazawa Univ., 2Dept. of Biol.
Sci., Virginia tech., 3Dept. of Phys., Nagoya Univ.)
3D−RISM 理論を応用した溶液中における Met−enkephalin の構造揺らぎの解析
Analysis of structural fluctuations of Met-encephalin in the solution phase by means of 3D-RISM
theoryMasatake Sugita1, Fumio Hirata2 (1Dept. of Bioinfo., Col. of Life Sci., Ritsumeikan Univ., 2Toyota Phys. &Chem. Res. Inst.)
Design of peptides to hasten actin depolymerization
Clement P. M. Scipion1,2, Robert C. Robinson1,2,3 (1INSTITUTE OF MOLECULAR AND CELL
BIOLOGY, 2NATIONAL UNIVERSITY OF SINGAPORE, 3Research Institute for Interdisciplinary Science,
Okayama University)
残基間コンタクトプロファイルに基づく MD 計算トラジェクトリの比較手法：PDZ3 ドメインと
CypA タンパク質への応用
Comparing two MD simulation trajectories in terms of residue-residue contact: detection ofallostery in PDZ3 domain and CypA protein
Chie Motono1, Takatsugu Hirokawa1,2 (1molprof, AIST, 2Fac Med., Univ. Tsukuba)
細胞骨格タンパク質であるビメンチンの細胞膜上への出現機構の解明
Elucidation of recruitment mechanism of vimentin to cell surface
Beomju Hwang1, Hirohiko Ise2 (1Grad. Sch. Eng., Kyushu Univ., 2IMCE, Kyushu Univ.)
酵素の触媒塩基におけるプロトンの配座転移に関するアンブレラ・サンプリング
Umbrella sampling on proton shift in catalytic base of enzyme
Kyosuke Sato (Dept. Mol. Phys., Fac. Life Sci., Kumamoto Univ.)
滴定 X 線溶液散乱を用いた GGA の構造と相互作用の解析
Structure and interaction analysis of GGA by using titration SAXS measurement
Yugo Hayashi1, Natsumi Endo1, Yoichi Yamazaki1, Kazuhisa Nakayama2, Soichi Wakatsuki3,
Hironari Kamikubo1 (1Div. Mat. Sci., NAIST, 2Grad. Sch. Pharm., Kyoto Univ., 3Stanford Univ.)
Ragulator-Rag GTPases 複合体構造における p18 の重要性
Crucial role of p18 component in assembly of Ragulator-Rag GTPases complex
Ryo Yonehara1, Shigeyuki Nada2, Tomokazu Nakai2, Masahiro Nakai2, Ayaka Kitamura2, Akira Ogawa2,
Hirokazu Nakatsumi3, Keiichi I. Nakayama3, Songling Li2, Daron M. Standley2, Eiki Yamashita1,
Atsushi Nakagawa1, Masato Okada2 (1Inst. for Protein Res., Osaka Univ., 2RIMD, Osaka Univ., 3Med. Inst.
of Bioregulation, Kyushu Univ.)
植物ホルモン「ブラシノステロイド」の生合成の鍵酵素 CYP90B1 の結晶構造解析
Structural insights into a key step of brassinosteroid biosynthesis
Keisuke Fujiyama1, Tomoya Hino1, Bunta Watanabe2, Hyoung Jae Lee3, Masaharu Mizutani3,
Shingo Nagano1 (1Grad. Sch. Eng., Tottori Univ., 2Inst. Chem. Res., Kyoto Univ., 3Grad. Sch. Agr., Kobe
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分子動力学シミュレーションを用いた抗 HIV 中和抗体 PG9 と PG16 の CDR-H3 についての構造
揺らぎの比較
Molecular dynamics study of structural Fluctuations in CDR-H3 of anti-HIV antibodies PG9 andPG16Naoki Tanabe1, Ryo Kiribayashi1, Hiroko X Kondo1, Daisuke Kuroda2, Toru Saito1, Jiro Kohda1,
Akimitsu Kugimiya1, Yasuhisa Nakano1, Kouhei Tsumoto3, Yu Takano1 (1Sch. Info. Sci., Hiroshima City
Univ., 2Grad. Sch. Eng., Univ. Tokyo, 3Inst. Med., Univ. Tokyo)
Crystal analysis investigates signaling molecule for general response protein RsbQ in Bacillus
subtilis
Nipawan Nuemket1, Kazuki Omichi2, Takashi Kumasaka1 (1JASRI/SPring-8, 2Kwansei Kaguin University)
部位特異的スピンラベル EPR 分光法による ABC トランスポーター; BhuUV の構造変化の実時間
測定
Real-time measurements of the conformational changes in ABC transporter; BhuUV, revealedby site-directed spin-labeling EPR spectroscopy
Kizashi Onishi, Motonari Tsubaki, Yasuhiro Kobori, Tetsunari Kimura (Grad. Sch. Sci., Kobe Univ.)
SR-Ca2+-ATPase におけるリガンド解離の分子動力学法シミュレーション
Molecular dynamics simulations for dissociation of ligands in SR-Ca2+-ATPase
Chigusa Kobayashi1, Yasuhiro Matsunaga1,2, Jaewoon Jung1,3, Yuji Sugita1,3,4 (1RIKEN R-CCS, 2JST
PRESTO, 3RIKEN TMS, 4RIKEN BDR)
Molecular simulation of protein conformational transition using a two-structure based model
Mashiho Ito, Ryota Mori, Tomoki P. Terada, Masaki Sasai (Nagoya Univ.)
網羅的構造解析によって示された基質結合蛋白質の天然変性領域の動的役割
Dynamic roles of intrinsically disordered regions of ligand binding proteins suggested by thecomprehensive structural search
Satoshi Omori, Hafumi Nishi, Kengo Kinoshita (Grad. Sch. of Info. Sci., Tohoku Univ.)
時計タンパク質 KaiC に組み込まれたアロステリック制御
Allosteric Regulation Designed in Clock Protein KaiC
Yoshihiko Furuike1,2, Atsushi Mukaiyama1,2, Eiki Yamashita3, Takao Kondo4, Shuji Akiyama1,2(1Research Center of Integrative Molecular Systems (CIMoS), Institute for Molecular Science (IMS),
2Department of Functional Molecular Science, SOKENDAI (The Graduate University for Advanced
Studies), 3Institute for Protein Research, Osaka University, 4Graduate School of Science, Nagoya
University)
全原子および粗視化シミュレーションによるバクテリアフリッパーゼ Pg1K の動作機構研究
Flipping mechanisms of bacterial flippase Pg1K studied by all-atom and coarse grained
simulations
Yutaka Murata, Toru Niina, Shoji Takada (Biophys. Sci. Kyoto Univ)
タンパク質の折れ畳みの協同性が語るトポロジーの選択性
Cooperativity of protein folding tells us about topology selectivity in genome
Nobu C. Shirai1, Shintaro Minami2 (1Center for Info. Tech. and Networks, Mie Univ., 2NINS, ExCELLS)
放射線生物：活性酸素／Radiobiology: Active oxygen

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銅イオン結合したプリオンペプチドのレドックスポテンシャル
Redox potential of copper-binding prion peptide
Shuhei Murakami, Yukihaya Watanabe, Wakako Hiraoka (Grad.Sch.of Sci.& Tech.,Meiji Univ)
酸化ストレスによるミトコンドリア電子伝達系機能異常の ESR 分析
ESR analysis of ROS-induced dysfunction of electron transport chain of mitochondria
Yukihaya Watanabe, Syuhei Murakami, Wakako Hiraoka (Grad. Sch. of Sci. & Tech., Meiji Univ)
NHEJ pathway mainly repairs lethal damage caused by the direct action of X-irradiation
Ryoichi Hirayama, Akiko Uzawa, Motofumi Suzuki, Sumitaka Hasegawa (QST NIRS)– S135 –生命の起源・進化／Origin of life & Evolution
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Evaluation of correlation between fluctuation of enzyme activity and evolvability by single
enzyme activity measurement
Morito Sakuma1, Hiroshi Ueno1, Kentaro Miyazaki2, Kazuhito Tabata1, Hiroyuki Noji1,3 (1Graduate
School of Engineering, The University of Tokyo, 2National Institute of Advanced Industrial Science andTechnology (AIST), 3Impulsing Paradigm Change through Disruptive Technologies Program (ImPACT,
JST))
High-throughput Laboratory Evolution of E. coli to Unveil Phenotypic Plasticity and Constraint
Chikara Furusawa1,2, Takaaki Horinouchi1, Tomoya Maeda1 (1BDR, RIKEN, 2UBI, Univ. Tokyo)
Natural Peptide-Oligomerization under Aqueous Condition
Muneyuki Matsuo1,2, Kensuke Kurihara2,3 (1The Univ. of Tokyo, 2Institute for Molecular Science,
3Exploratory Research Center on Life and Living Systems)
鋳型ライゲーションにおいて頻度依存的な選択がエラーカタストロフィーを抑制する
Suppression of error catastrophe by frequency-dependent information selection in templatedirected ligation
Yasuhiro Magi, Shoichi Toyabe (Appl. Phys., Tohoku Univ.)
Experimental demonstration of information retention against diffusional mixing in templated
ligation
Kazuki Hata, Shoichi Toyabe, Yasuhiro Magi (Tohoku University)
生体膜・人工膜／Biological & Artificial membrane: Structure & Property

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せん断変形と狭窄変形における細胞粘弾性の負荷時間依存性
Loading-time dependence of cellular viscoelasticity under shear and squeezing deformation
Hiroaki Ito1, Atsushi Kirimoto1, Naoki Takeishi2, Makoto Kaneko1 (1School of Engineering, Osaka
University, 2School of Engineering Science, Osaka University)
Effect of lateral phase separation on mechanical stability of lipid membrane
Mika Terada, Yukihiro Tamba (Natl. Inst. of Tech., Suzuka Coll.)
抗菌ペプチド・PGLa と単一 GUV との相互作用とそれが誘起するポア形成
Interaction of Antimicrobial Peptide PGLa with Single Giant Unilamellar Vesicles and its Induced
Pore Formation
Farliza Parvez1, Md Jahangir Alam3, Hideo Dohra2, Masahito Yamazaki1,3,4 (1Grad. Sch. Sci. Tech.,
Shizuoka Univ., 2Res. Inst. Green Sci. Tech., Shizuoka University, 3Res. Inst. Ele., Shizuoka Univ., 4Grad.
Sch. Sci., Shizuoka Univ.)
脂質分子のフリップ・フロップに対する膜張力の効果
Effect of Membrane Tension on Transbilayer Movement of Lipids
Moynul Hasan1, Samiron Kumar Saha1, Masahito Yamazaki1,2,3 (1Grad. Sch. Sci. Tech., Shizuoka Univ.,
2Res. Inst. Ele., Shizuoka Univ., 3Grad. Sch. Sci., Shizuoka Univ.)
リン脂質フリッパーゼ発現による細胞膜の粘度への影響
Effect of flippases expression on viscosity of plasma membranes
Haruna Hayashi1, Naoto Takada2, Akira Takakado1, Hye-Won Shin2, Koichi Iwata1 (1Fac. of Sci.,
Gakushuin Univ., 2Grad. of Pharm. Sci., Kyoto Univ.)
バクテリアの推進力によるリポソーム膜の形態変化
Morphological changes of liposomes by bacterial propulsion force
Mai Hayakawa1, Terajima Hazuki1, Masamune Morita2, Tomoyuki Kaneko1 (1LaRC, FB, Hosei Univ.,
2Biomed. Res. Inst. AIST)– S136 –1Pos090

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抗菌ペプチド・マガイニン２が誘起するポア形成に対する膜界面疎水性の効果
Role of Interfacial Hydrophobicity in Antimicrobial Peptide Magainin 2 (mag)-Induced Pore
Formation
Moynul Hasan1, Md. Mamun Or Rashid1, Hideo Dohra2, Masahito Yamazaki1,3,4 (1Grad. Sch. Sci. Tech.,
Shizuoka Univ., 2Res. Inst. Green Sci. Tech., Shizuoka University, 3Res. Inst. Ele., Shizuoka Univ., 4Grad.
Sch. Sci., Shizuoka Univ.)
モデル膜を用いたコレステロール依存性細胞溶解毒素の膜結合活性評価
Evaluation of binding activity of cholesterol-dependent cytolytic toxin using model membranes
Nobutake Tamai1, Tohru Morimitsu2, Masaki Goto1, Hideaki Nagamune1, Hitoshi Matsuki1 (1Grad. Sch.
Tech. Indus. Soc. Sci., Tokushima Univ., 2Grad. Sch. Adv. Tech. Sci., Tokushima Univ.)
コレステロールによる薬剤クロルゾキザソン脂質膜結合抑制効果のリン脂質種依存性
Phospholipid species dependence of cholesterol inhibition effect on the bind of chlorzoxazone
to lipid membrane
Hiroshi Takahashi, Shosei Kano (Biophys. Lab. Gunma Univ.)
気液界面における脂質単分子膜へのコレステロールと人工肺サーファクタントタンパク質 B の影
響
Effect of cholesterol and synthetic lung surfactant protein B on a lipid monolayer at the air-waterinterface
Hideyuki Nagatsuka, Masahiro Hibino (Div. Sustain. Environ. Eng., Muroran Inst. Tech.)
粗視化モデルによる二成分脂質膜の構造安定性に関する理論的研究
Theoretical study on the conformational stability of binary lipid membrane by a coarse-grainedmodel
Tetsu Matsuura, Tomoya Maeda, Kazutomo Kawaguchi, Hidemi Nagao (Grad. Sch. Nat. Sci. Tech.
Kanazawa Univ.)
抗菌ペプチド・ラクトフェリシン B と単一大腸菌や大腸菌由来の脂質の GUV との相互作用
Interaction of antimicrobial peptide lactoferricin B (Lfcin B) with single E. coli cells and single
vesicles of extract lipids
Farzana Hossain1, Md. Moniruzzaman1, Md. Mizanur Moghal1, Masahito Yamazaki1,2,3 (1Grad. Sch. Sci.
Tech., Shizuoka Univ., 2Res. Inst. Ele., Shizuoka Univ., 3Grad. Sch. Sci., Shizuoka Univ.)
膜透過ペプチド・オリゴアルギニンの抗菌活性と単一大腸菌との相互作用
Antimicrobial activity of cell-penetrating peptide oligoarginine and its interaction with single cells
of Escherichia coli
Sabrina Sharmin1, Hideo Dohra2, Masahito Yamazaki1,3,4 (1Grad. Sch. Sci. Tech., Shizuoka Univ., 2Res.
Inst. Green Sci. Tech., Shizuoka University, 3Res. Inst. Ele., Shizuoka Univ., 4Grad. Sch. Sci., Shizuoka
Univ.)
脂質二重膜の組成が EGFR JM 領域の二量体構造に与える影響
Investigation of the correlation between lipid composition and the dimer structure of EGFR JM
regionDaisuke Matsuoka1, Yasuhiro Matsunaga2, Yuji Sugita1,2,3 (1RIKEN, Theoreitcal Molecular Science,
2RIKEN R-CCS, 3RIKEN BDR)
Substrate-supported model biological membrane with controlled two-dimensional and threedimensional structures
Sawako Kobayashi1, Ryota Komatsu1, Kennichi Morigaki2 (1Graduate School of Agricultural Science,
Kobe University, 2Biosignal Research Center, Kobe University)
非対称膜組成の小胞封入ベシクルの作製
Formation of giant vesicle containing small vesicles with asymmetric lipid membranes
Koki Kamiya1, Toshihisa Osaki1,2, Shoji Takeuchi1,2 (1Kanagawa Institute of Industrial Science andTechnology, 2IIS, university of Tokyo)
逆相遠心法による巨大リポソームの迅速形成・精製とその特性
Giant vesicles rapidly prepared and purified using a reverse-phase/centrifugation method
Kanta Tsumoto, Kohei Nakano, Yuki Hayashi, Masahiro Tomita (Grad. Sch. Eng., Mie Univ.)– S137 –1Pos101

Development of a polarized coarse grained water model and its application in lipid membrane
systems
Yuusuke Miyazaki, Susumu Okazaki, Wataru Shinoda (Grad. Sch. Eng., Nagoya Univ.)
ゲノム生物学／Genome biology: Genome analysis

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ニック DNA のナノポアへのつまりと特異的挙動
Clogging and returning of nicked DNA at nanopores
Kento Lloyd, Seiya Minato, Tomoya Kubota, Toshiyuki Mitsui (Grad. Sch. of Sci. & Eng., Aoyama
Gakuin Univ.)
A datamining approach for genotype-phenotype correlation of SCN1A-related epilepsies basedon physico-chemical properties changes
Shuichi Yoshida, Takuhiro Nishio (Dept. of Physics, Hamamatsu Univ. Sch. Med.)
数理モデルとライブイメージングデータを用いた分裂酵母間期核内構造の解析
Analysis of fission yeast interphase intranuclear structure by mathematical model and live
imaging data
Yuki Takayama1, Hiroaki Ito2, Hisamichi Senda2, Hiraku Nishimori1, Masaru Ueno2, Akinori Awazu1(1Grad. Sch. Sci., Univ. Hiroshima, 2Grad. Sch. Advanced Sciences of Matter, Univ. Hiroshima)
ヌクレオチド組成空間におけるハビタブルゾーンの生物的意味
Biological meaning of “habitable zone” in nucleotide composition space
Shigeki Mitaku1, Ryusuke Sawada2 (1Emeritus Prof. Nagoya Univ., 2Med. Inst. Bioregulation, Kyushu
Univ.)
Dynamic changes in the interchromosomal interaction of early histone gene loci during
development of sea urchin
Masaya Matsushita, Hiroshi Ochiai, Ken-ichi Suzuki, Sayaka Hayashi, Ayaka Sugiyama,
Takashi Yamamoto, Akinori Awazu, Naoaki Sakamoto (Dept. of Math and Life Sci. Hiroshima Univ.)
大腸菌における走化性関連タンパク質のコドン使用傾向
Pattern of codon usage for chemotaxis related protein genes in E.coli
Serika Taga1, Nobuyuki Uchikoga2, Takanori Sasaki3 (1Grad. Sch. Adv. Math. Sci., Meiji Univ, 2Catalyst,
3Grad. Sch. Adv. Math. Sci., Meiji Univ)
遅発性アルツハイマー病に関連する新規ゲノム領域の網羅的探索
Comprehensive Search of Novel Genome Regions Related to Late-Onset Alzheimer’s Disease
Yudai Hirose, Hiraku Nishimori, Akinori Awazu (Department of Mathematical and Life Sciences,
Hiroshima University)
核膜変形と核内流体を考慮した分裂酵母染色体動態の物理モデル
Physical model of fission yeast chromosome dynamics considering nuclear envelope
deformation and intranuclear hydrodynamics
Kazutaka Takao, Hiraku Nishimori, Akinori Awazu (Dept. Math and Life Sci., Hiroshima Univ.)
Dynamics and organization of slow nucleosomes in live mammalian cells
Ashwin Selvarajan S1, Tadasu Nozaki2, Kazuhiro Maeshima2, Masaki Sasai1 (1Department of Applied
Physics, Nagoya University, Nagoya, Japan, 2Structural Biology Center, National Institute of Genetics,
Mishima, Japan)– S138 –筋肉／Muscle
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心筋の調節タンパク質トロポニンは構造多型をカルシウムとリン酸化により部分的にシフトさせる：二量子遷移(DQC)ESR 距離測定による研究
Calcium and phosphorylation partially shifts multiple conformations of cardiac troponin:
Distance study by double quantum coherence ESR
Toshiaki Arata1,2, Jun Abe3, Shoji Ueki4, Yasunori Ohba3 (1Dept. Biol., Grad. Sch. Sci., Osaka City Univ.,
2Dept. Biol. Sci., Grad. Sch. Sci., Osaka Univ., 3Inst. Multidisciplinary Res. Adv. Materials, Tohoku Univ.,
4Kagawa Sch. Pharmaceutical Sci., Tokushima Bunri Univ.)
FRET で捉えたアクチン繊維末端付近の構造ゆらぎ
B- or P-ends of actin filament can be determined by measuring the fluctuation of FRET
efficiencies
Ryota Mashiko1, Hirotaka Ito1, Ryusei G Ebata1, Kenji Kamimura2, Hajime Honda1 (1Dep. Bioeng.,
Nagaoka Univ., 2Tech, Dep. Elect. Contr. Eng., NIT, Nagaoka College)
細胞クラスター構成法を用いた心筋細胞の拍動同期化における集団効果の解明
Community effect of cardiomyocytes in synchronous behavior of beating by constructing cellcluster (1): Experimental approach
Naoki Takahashi1, Akihiro Yamashita2, Kazuhumi Sakamoto3, Masao Odaka4,5, Akihiro Hattori4,5,
Kenji Matsuura4,5, Kenji Yasuda1,3,4,5 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda
Univ., 2Dept. Adv. Sci. & Eng., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 3Dept. Pure & Appl. Phys., Sch.
Adv. Sci. & Eng., Waseda Univ., 4Org. Univ. Res. Initiatives, Waseda Univ., 5WASEDA Biosci. Res. Ins. in
Singapore)
アクチン分子の構造多様性について
Polymorphism of actin molecules
Toshiro Oda1, Shuichi Takeda2, Akihiro Narita2, Yuichiro Maeda2,3 (1Fac. Health and Welfare,
Tokaigakuin Univ., 2Struct. Biol. Res. Center, Grad. Sch. Sci., Nagoya Univ., 3TOYOTA RIKEN)
表面プラズモン共鳴を用いた β-アドレナリン刺激に関わる心筋トロポニン分子内相互作用の研究
Surface plasmon resonance studies of the intramolecular interaction in cardiac troponinconcerned with β-adrenergic stimulation
Yurie Inamoto1, Toshiaki Arata2, Shoji Ueki1 (1Kagawa Sch. of Pharm.Sci.,Tokushima Bunri Univ.,
2Grad.Sch.Sci.,Osaka City Univ.)
高静水圧下におけるマウス心筋細胞への影響
High hydrostatic pressure induces cardiomyocyte contraction
Yohhei Yamaguchi1, Masayoshi Nishiyama2, Hiroaki Kai3, Gentaro Iribe3, Keiji Naruse3,
Masatoshi Morimatsu3 (1Asahikawa Med. Univ., 2Kindai Univ., 3Okayama Univ.)
分子モーター／Molecular motor

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Bacillus PS3 FoF1-ATP 合成酵素の H+輸送活性の顕微鏡 1 リポソーム解析
Microscopic single liposome analysis of H+-translocating activity of Bacillus PS3 FoF1-ATP
synthase
Naoya Iida1, Yuzo Kasuya1, Naoki Soga2, Taro Uyeda1, Masasuke Yoshida3, Kazuhiko Kinosita1,
Toshiharu Suzuki2,3,4 (1Dept. Physics, Waseda Univ., 2Dept. Eng, Univ. of Tokyo, 3Dept. Mol Biochem,
Kyoto Sangyo Univ, 4CLS, Tokyo Inst of Tech)
Rotation of the engineered F1-ATPase with non-catalytic α-type P-loops
Hiroshi Ueno1, Rie Koga2, Tomoko Masaike3, Nobuyasu Koga2, Hiroyuki Noji1 (1Grad. Sch. Eng., Univ.
Tokyo, 2ExCELLS, NINS, 3Grad. Sch. Sci. Tech., Tokyo Univ. of Sci.)– S139 –1Pos209

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ヒンジ領域を非触媒型に置換した触媒サブユニットをもつ F1-ATPase の回転トルクと反応速度
Rotational torque and kinetics of F1-ATPase containing the catalytic subunit with a non-catalytic
hinge
Tomoyasu Sato1, Hiroshi Ueno2, Kumiko Hayashi3, Rie Koga4, Nobuyasu Koga4, Hiroyuki Noji2,
Tomoko Masaike1 (1Dept. Appl. Biol. Sci., Grad. Sch. Sci. Tech., Tokyo Univ. of Sci., 2Dept. Appl. Chem.,
Grad. Sch. Eng., Univ. Tokyo, 3Dept. Appl. Phys., Grad. Sch. Eng., Tohoku Univ., 4ExCELLS, NINS)
好熱菌 F1 による ATP 加水分解におけるリン酸解離のタイミング
On the timing of phosphate release in the ATPase reaction by TF1
Eiro Muneyuki1, Yohei Nakayama1, Shoichi Toyabe2, Hiroshi Ueno3 (1Department of Physics, Faculty of
Science and Engineering, Chuo University, 2Department of Applied Physics, Graduate School ofEngineering, Tohoku University, 3Department of Applied Chemistry, Graduate School of Engineering, The
University of Tokyo)
F1-ATPase の構造変化に α と β の P-loop 配列の違いが及ぼす影響
Impact of the sequence difference of P-loop on the conformational changes of F1-ATPase
Rie Koga1, Hiroshi Ueno2, Tomoko Masaike3, Hiroyuki Noji2,4, Nobuyasu Koga1 (1ExCELLS, NINS,
2Dept. Appl. Chem., The Univ. Tokyo, 3Dept. Appl. Biol. Sci., Tokyo Univ. of Sci., 4ImPACT, JST)
Assignment of subunit components in motor evolved from F-ATPase for Mycoplasma mobile
gliding
Takuma Toyonaga1, Takayuki Kato2, Akihiro Kawamoto3, Noriyuki Kodera4, Toshio Ando4,
Keiichi Namba2,5, Makoto Miyata1,6 (1Grad. Sch. Sci., Osaka City Univ., 2Grad. Sch. Front. Biosci., Osaka
Univ., 3IPR, Osaka Univ., 4Bio-AFM FRC, Kanazawa Univ., 5BDR & SPring-8, Riken, 6OCARINA, Osaka
City Univ.)
Half channels and unidirectional rotation in the FO sector of E. coli ATP synthase observed bymolecular dynamics simulation
Dan Parkin, Daiki yamakoshi, Mitsunori Takano (Dept. of Pure & Appl. Phys., Waseda Univ.)
細菌べん毛モーターの回転方向変換制御機構の解明
Elucidation of the directional switching mechanism of the bacterial flagellar motor by electron
cryomicroscopy
Tomoko Miyata1, Takayuki Kato1, Akihiro Kawamoto2, Fumiaki Makino1, Namba Keiichi1,3 (1Grad. Sch.
Frontier Biosci., Osaka Univ., 2IPR, Osaka Univ., 3BDR & SPring-8, RIKEN)
Effect of pH on rotation of the proton-driven bacterial flagellar motor under near zero load
Yuta Hanaizumi1, Shuichi Nakamura1,2, Yusuke V. Morimoto2,3, Tohru Minamino2, Keiichi Namba2,4(1Grad.Sch.Eng.,Tohoku Univ., 2Grad.Sch.Frontier Biosci.,Osaka Univ., 3Dept. of Biosci. Bioinfo., Kyushu
Inst. Tech., 4QBiC,RIKEN)
Feedback regulation of the ion channel activity of the flagellar motor stator complex
Naoya Terahara1, Keiichi Namba1,2, Tohru Minamino1 (1Grad. Sch. Frontier BioSci., Univ. Osaka, 2BDR
and Spring8 RIKEN)
海洋性ビブリオ菌べん毛モーター固定子 PomA タンパク質の Cys 変異導入を用いた細胞質領域
荷電残基の構造解析
Analysis of charged residues by Cys mutagenesis in cytoplasmic loop of flagellar motor protein
PomA of marine Vibrio
Taira Mino, Tatsuro Nishikino, Hiroto Iwatsuki, Seiji Kojima, Michio Homma (Nagoya Univ, Sch Science,
Biological Sci)
Stator-units distribution and dynamics of E. coli sodium-driven chimera flagella motor
Tsai-Shun Lin1, Michio Homma2, Seiji Kojima2, Chien-Jung Lo1 (1National Central Univ.,Taiwan, 2Grad.
sch. of Sci., Nagoya Univ.)
Paenibacillus sp. TCA20 がもつ二価カチオン駆動型べん毛モーター固定子 MotA1MotB1 の機能
解析
Characterization of ion specificity of MotA1/MotB1 in Paenibacillus sp. TCA20
Sakura Onoe1, Myu Yoshida2, Masahiro Ito3, Yoshiyuki Sowa1,2,4 (1Grad. Sch. Sci. & Eng., Hosei Univ.,
2Dept. Frontier Biosci., Hosei Univ., 3Grad. Sch. Life Sci. Toyo Univ., 4RC. Micro-nano Tech., Hosei Univ.)– S140 –1Pos220
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Investigating the Growth Mechanism of Bacterial Flagella by Real-time Fluorescencet Imaging
Xiang-Yu Zhuang, Chien-Jung Lo (Department of physics, National Central University)
線毛を使って運動する桿菌とその走化性に関するシミュレーション
Simulation study of bacillus moving with pili and its chemotaxis
Ryota Morikawa, Masatada Tamakoshi, Takeshi Miyakawa, Masako Takasu (School of Life Sciences,
Tokyo University of Pharmacy and Life Sciences)
Rng2 のアクチン結合部位は、HMM で駆動されるアクチン運動を強くかつ協同的に阻害する
Potent and highly cooperative inhibition of actin movement on HMM by actin binding domain ofRng2
Yuuki Hayakawa1, Kien X Ngo2, Noriyuki Kodera2, Taro Uyeda1 (1Grad. Sch. Faculty of Sci. and Eng.,
Waseda Univ., 2WPI NanoLSI., Kanazawa Univ.)
Molecular Structures of Actin Filaments Bound with α-Actinin, Tropomyosin-Troponin and
Myosin II Analyzed by High Speed AFM
Kien Xuan Ngo1, Noriyuki Kodera1, Taro Q.P. Uyeda2 (1Nano Life Science Institute (WPI-NanoLSI),
Kanazawa University, 2Department of Physics, Faculty of Advanced Science and Engineering, Waseda
University)
Myosin minifilament-driven fragmentation of actin filaments triggers contraction of a disorderedactin network
Kyohei Matsuda1, Takuya Kobayashi2, Mitsuhiro Sugawa1, Yurika Koiso1, Yoko Y. Toyoshima1,
Junichiro Yajima1 (1Grad school of arts and sciences, Univ. of Tokyo, 2Juntendo Univ. Grad School of
Medicine)
歩行運動中のミオシン VI の前足のブラウン運動の自由エネルギーランドスケープ
Free energy landscape for the Brownian motion of the leading head of myosin VI during the
stepping motion
Tomoki P. Terada1, Qing-Miao Nie2, Masaki Sasai1 (1Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.,
2Dept. Appl. Phys., Zhejiang Univ. Tech.)DNA オリガミ-ミオシン II モーター混合システムの 1 分子解析
Single molecule analysis of DNA origami-myosin II motor hybrid system
Hiroki Fukunaga1, Masashi Ohmachi2, Keisuke Fujita2, Keigo Ikezaki3, Toshio Yanagida1,2,
Mitsuhiro Iwaki1,2 (1FBS, Univ. Osaka, 2BDR, Riken, 3Grad. Sch. Sci., Univ. Tokyo)
アクチンフィラメントに対するヘビーメロミオシンの協同的結合の方向性の解析
Analysis of the direction of cooperative binding of heavy meromyosin to actin filaments
Naoyuki Muratsubaki1, Rika Hirakawa1, Taro Q.P. Uyeda2, Kiyotaka Tokuraku1 (1Grad. Sch. Sustain,
Environ. Eng., Muroran Inst. Technol., 2Waseda Univ.)
高速原子間力顕微鏡による人工ミオシンフィラメントでのミオシン II モーターの可視化
Direct visualization of individual myosin II motors in artificial myosin filaments by high-speed
AFM
Masashi Ohmachi1, Keigo Ikezaki3, Toshio Yanagida1,2, Mitsuhiro Iwaki1,2 (1BDR, Riken, 2Grad. Sch.
Front. Biosci., Osaka Univ., 3Grad. Sch. Sci., Univ. Tokyo)
神経・感覚／Neuroscience & Sensory systems

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アミロイド β（1-40）ペプチドと人工 GM1 糖鎖クラスターの複合体形成シミュレーション p
Binding Simulations of an Amyloid-β (1-40) peptide to an Artificial GM1 Glycan Cluster
Yuhei Tachi1,2, Yuko Okamoto1, Hisashi Okumura2,3,4 (1Graduate school of Science, Nagoya University,
2Institute for Molecular Science, 3The Graduate University for Advanced Studies, 4Exploratory ResearchCenter on Life and Living Systems)– S141 –1Pos302

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アミロイド β の凝集はアクチンに富む細胞辺縁部で凝集が促進される
Aggregation of amyloid β was induced at the actin-rich cell periphery
Yusaku Chikai1, Ryota Yamashita2, Masahiro Kuragano3, Masayuki Takahashi4, Kiyotaka Tokuraku5(1Dep. App. Sci., Muroran Inst. Technol., 2Grad. Sch. Sustain., Environ. Eng., Muroran Inst. Technol.,
3Grad. Sch. Chem. Sci. Eng., Univ. Hokkaido., 4Grad. Sch. Chem. Sci. Eng., Univ. Hokkaido., 5Grad. Sch.
Sustain., Environ. Eng., Muroran Inst. Technol.)
シナプス後肥厚部タンパク質群の自己集積のメソスケール分子シミュレーション研究
Mesoscopic Molecular Simulation for Self-assembly of the Postsynaptic Density Proteins
Hana Slevin Ohama, Diego Ugarte, Shoji Takada (Dept. Biophysics, Div. Biology, Graduate School of
Science, Kyoto University)
AFM 細胞間接着力測定技術を用いた腫瘍内細胞間接着力の in vitro 解析
Measurements of intercellular adhesions of tumor microenvironment cells in vitro by using AFM
Kenta Ishibashi1, Tomoko Okada2, Chikashi Nakamura1,2, Hyonchol Kim1,2 (1Grad. Sch. Eng., Tokyo
Univ. Agric. Technol., 2Biomed. Res. Inst., AIST)
全身麻酔薬プロポフォールによる蛙坐骨神経の複合活動電位抑制とその化学構造
Inhibition by general anesthetic propofol of frog sciatic nerve compound action potential and its
chemical structure
Nobuya Magori, Tsugumi Fujita, Kotaro Mizuta, Eiichi Kumamoto (Department of Physiology, Faculty of
Medicine, Saga University)
Chemosensing-neuron regulates cold tolerance via Ca2+-dependent endoribonuclease with
apoptotic signaling in C. elegans
Atsushi Kuhara1,5, Tomoyo Ujisawa1, Atsushi Toyoda3, Katsushi Arisaka4, Miki Ii2, Akane Ohta1(1Institute for Integrative Neurobiology, Konan University, 2University of Alaska Anchorage, 3National
Institute of Genetics, 4UCLA, 5PRIME, AMED)
ミミズ繰り返し体壁刺激による慣れの神経機構
Mechanism of habituation by repeated tactile stimulus in earthworm
Yoshiichiro Kitamura, Haruya Fujita, Yoshiki Funahashi (Department of Mathematical Sciences andPhysics College of Science and Engineering, Kanto Gakuin University)
エピカテキンはヨーロッパモノアラガイの味覚嫌悪学習による長期記憶形成を増強する
Epicatechin enhances the long-term memory formation for taste-aversive conditioning in thepond snail
Yoshimasa Komatsuzaki1, Tetsuya Iwahori1, Shogo Nakada2, Ayaka Itoh2, Sho Tozawa1, Ken Lukowiak3,
Minoru Saito2 (1Dept. Phys., Coll. Sci. Tech., Nihon Univ., 2Dept. Biosci., Coll. Hum. Sci., Nihon Univ.,
3Hotchkiss Brain Inst., Fac. Med., Univ. Calgary)
神経回路・脳の情報処理／Neuronal circuit & Information processing

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インビボでの周波数依存性シナプス可塑性の数学的解析
Mathematical analysis of the frequency-dependent synaptic plasticity in vivo
Katsuhiko Hata1,2,3,4,5, Osamu Araki6, Osamu Yokoi2,4, Toshiaki Kaminaka2,4, Tatsuya Saka2,4,
Izumi Kuboyama1, Susumu Ito3, Tetsuro Nikuni5 (1Sch. Emerg. Med. Sys. Kokushikan Univ., 2DPEMS,
Kokushikan Univ, 3High-Tech Res. Cent., Kokushikan Univ, 4Res Cent for Math Med, 5Dept of Phys TUS,
6Dept of Ap Phys TUS)
Reinforcement learning using Deep Deterministic Policy Gradient (DDPG) with image input
Keisuke Hara1, Naoto Kobayashi1, Hideo Mukai2 (1Graduate School of Science and Technology, Meiji
University, 2School of Science and Technology, Meiji University)– S142 –1Pos311

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光ファイバー集束光加熱光学系を用いた高精度・非侵襲オンチップアガロースパターン構築技術の開発
A 1064/1480-nm photo-thermal etching system with fiber optics for an accurate and noninvasive micropatterning of an agarose thin layer
Takahito Kikuchi1, Shota Aoki1, Yuhei Tanaka2, Masao Odaka3,4, Akihiro Hattori3,4, Kenji Matsuura3,4,
Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure &Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda Univ., 4WASEDA
Biosci. Res. Ins. in Singapore (WABIOS))
プラズモニックチップ上の増強蛍光による培養神経細胞の自発活動計測
Spontaneous activity in cultured neurons measured with the enhanced fluorescence on theplasmonic chip
Wataru Minoshima1, Chie Hosokawa2, Suguru Kudoh1, Keiko Tawa1 (1Kwnasei Gakuin University,
2National Institute of Advanced Industrial Science and Technology)
神経突起伸長速度に対する細胞集団サイズとチャネル幅の効果
Effect of cell cluster size and channel width to neurite elongation rate
Hayato Toriumi, Tomoyuki Kaneko (LaRC, FB, Hosei Univ)
外部からの磁気刺激に対する神経細胞の応答 - 刺激強度依存性
Response of nerve cells to external magnetic stimulation - Stimulation intensity dependence
Toshiaki Kaminaka1,2, Osamu Yokoi1,2,3, Tatsuya Saka1,2,3, Susumu Ito4, Izumi Kuboyama5,
Katsuhiko Hata1,2,3,4,5 (1Res Cent for Math Med, 2DPEMS Kokushikan Univ, 3TUS, 4HRC,Kokushikan Univ,
5Sch. Emerg. Med. Sys, Kokushikan Univ)
オンチップ多電極システムによる孤立神経１細胞自発発火の電位変化の解析
Extracellular field potential change analysis of spontaneous firing of an isolated neuron by an
on-chip multi-electrode array system
Shota Aoki1, Takahito Kikuchi1, Yuhei Tanaka2, Kenji Matsuura3,4, Akihiro Hattori3,4, Masao Odaka3,4,
Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure &Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda Univ., 4WASEDA
Biosci. Res. Ins. in Singapore (WABIOS))
神経活動電位系列の生成解読様式とその情報伝送容量について
Encoding and decoding of neural pulse code system and its channel capacity
Susumu Ito1, Toshiaki Kaminaka2, Katsuhiko Hata1,2,3, Izumi Kuboyama3 (1HRC,Kokushikan Univ,
2Res.Cent.Math.Med, 3Sch.Emerg.Med.Sys, Kokushikan Univ)
線虫のシナプス結合経路と全中枢神経細胞活動データから推定したシグナル経路の頑健性
Robustness of synaptic pathway and signaling pathway estimated from the whole-brain activity
data in C. elegans
Yuishi Iwasaki1, Hirofumi Sato2, Suzu Oe3, Sayuri Kuge3, Takayuki Teramoto3, Terumasa Tokunaga4,
Osamu Hirose5, Stephen Wu6, Yu Toyoshima2, Moon Sun Jang2, Ryo Yoshida6, Yuichi Iino2,
Takeshi Ishihara3 (1Fac. Eng., Ibaraki Univ., 2Grad. Sch. Sci., Univ. Tokyo, 3Grad. Sch. Sci., Kyushu Univ.,
4Grad. Sch. Comp. Sci. and Sys. Eng., Kyushu Institute Tech., 5Institute. Sci. and Eng., Kanazawa Univ.,
6Institute Stat. Math.)
海馬で合成される男性・女性ホルモンやストレスホルモンによる記憶シナプスの non-genomic な制御
Non-genomic modulation of synapses by hippocampus-synthesized androgen, estrogen andstress steroid
Suguru Kawato1,2, Mika Soma1, Mari Ogiue-Ikeda1 (1Dep. Cognitive Neuroscience, Pharma-Science,
Teikyo Univ., 2Dep. Urology, Grad Sch Medicine, Juntendo Univ.)– S143 –1Pos319

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アガロース微細構造を用いた二つの海馬細胞から伸長する２つの神経突起の反発相互作用の解析
Repulsive interactions of two neurites elongated from two isolated hippocampal cells in agarose
width-length-controlled microchannels
Yuhei Tanaka1, Takahito Kikuchi2, Shota Aoki2, Akihiro Hattori3,4, Kenji Matsuura3,4, Masao Odaka3,4,
Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure & Appl.
Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda Univ., 4WASEDA
Biosci. Res. Ins. in Singapore)
小脳核ペリニューロナルネットによる GABA シナプス伝達修飾と運動学習制御
Perineuronal nets in the deep cerebellar nuclei modulate GABAergic transmission and regulate
motor learning
Moritoshi Hirono1, Satoshi Watanabe2, Fuyuki Karube1, Fumino Fujiyama1, Shigenori Kawahara3,
Soichi Nagao4,5, Yuchio Yanagawa6, Hiroaki Misonou1 (1Grad. Sch. Brain Sci., Doshisha Univ., 2Natl Inst
Neurosci, NCNP, 3Grad. Sch. Sci. Eng., Univ. Toyama, 4Lab. Motor Learning Control, RIKEN BSI, 5Lab.
Integrative Brain Functions, Nozomi Hospital, 6Dep. Genetic and Behav. Neurosci., Gunma Univ. Grad.
Sch. Med.)発生・分化／Development & Differentiation

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どのように神経突起は軸索および樹状突起へと個性化するのか？ ～微小管配向動態の観点から～
How neurites acquire identity of axon and dendrites through microtubule orientation dynamics?
Naoki Honda (Grad. Sch. Biostudies., Kyoto Univ.)
細胞性粘菌の細胞分化に伴う細胞質 pH 変化
Changes in cytoplasmic pH following the cell differentiation in Dictyostelium
Yusuke V. Morimoto1,2, Masahiro Ueda2,3 (1Dept. of Biosci. Bioinfo., Kyushu Inst. Tech., 2RIKEN, BDR,
3Grad. Sch. Frontier Biosci., Osaka Univ.)
ヒト誘導多能性幹細胞由来の内胚葉および中胚葉による原腸形成期の移動
Migration of Endoderm and Mesoderm Derived from Human Induced Pluripotent Stem Cells
during Human Gastrulation Stage
Kenshiro Maruyama1, Ryo Kobayashi2, Kiyoshi Ohnuma1 (1Grad. Sch. Eng., Univ. Nagaoka Tech., 2Dept.
BioEng., Univ. Nagaoka Tech.)
細胞分裂、分化、発生過程を細胞内小器官の 3D 構造モデルから読み解くための試み
Attempt to understand cell division, differentiated, developmental process from 3D structuralmodel of intracellular organelle
Takako M. Ichinose1, Takeshi Itabashi1,2,3, Hikari Mori1, Junpei Kuroda4, Shigeru Kondo4,
Atsuko H. Iwane1,2,3 (1Cell Field Struc., BDR, Riken, 2Spec. Res. Promot. Group, Grad. Sch. Fronti.,
Biosci., Osaka Univ., 3Grad. Sci., Hiroshima Univ., 4Pattern formation, Grad. Sch. Fronti., Biosci., Osaka
Univ.)
線虫 C. elegans 胚発生における細胞形状ダイナミクスの定量解析
Quantitative analysis of cell shape dynamics in C. elegans embryogenesis
Yusuke Azuma, Shuichi Onami (RIKEN BDR)
初期胚発生における力学モデルの解析
Analyzing and modeling of early embryo development
Takaaki Matsui1, Tetsuya Kobayashi2 (1Grad. Sch. Eng. EEIS, Univ.Tokyo, 2IIS, Univ.Tokyo)– S144 –計測／Measurements
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紫外可視光変換システムとゲル固体電気化学素子のセンサーへの応用と水素化アモルファスシリ
コン薄膜の効果
Ultra violet visible light conversion system and gel electrochemical element for sensor and theeffect of hydrogenated amorphous silicon
Koki Shimanaka1, Makoto Horigane1, Shotaro Minato1, Miku Kaneta1, Norimi Takahashi1,
Shota Murakami1, Hiroshi Masumoto2, Takashi Goto3, Yutaka Tsujiuchi1 (1Material Science andEngineering, Akita University, 2Frontier Research Institute for Interdisciplinary, Tohoku University,
3Institute for Materials Research, Tohoku University)
マイクロ流路を用いた連続滴定用オートサンプリングシステムの改良
Improvement of the micro-fluidics based auto sampling system designed for continuous titration
experiments
Shinji Amano, Yugo Hayashi, Yoichi Yamazaki, Hionari Kamikubo (Div. Mat. Sci., NAIST)
HPD による広視野多色蛍光 1 分子検出
Wide-field single-molecule multicolor fluorescence detection by hybrid photo-detectors (HPDs)
Atsuhito Fukasawa1, Gaku Nakano1, Hiroaki Yokota2, Minako Hirano2, Toru Ide3 (1Hamamatsu
Photonics K.K., 2Grad. Sch. Creation Photon Indust., 3Grad. Sch. Nat. Sci. Technol., Okayama Univ.)
水溶液中における蛍光タンパク質発色団の赤外スペクトル−過渡蛍光を利用した新規手法の開発−
IR spectrum of fluorescent protein chromospheres in water -Development of a transient
fluorescence-detected resonance IR spectroscopyHirona Takahashi, Tomoya Miyake, Tatsuya Oue, Makoto Sakai (Okayama University of Science)
偏光蛍光相関分光法(Pol-FCS)による回転拡散成分振幅の配向依存性の研究
Study of the orientation dependency of fraction of rotational diffusion in Polarization-dependent
Fluorescence Correlation Spectroscopy
Satoru Momosaki1, Johtaro Yamamoto2,3, Masataka Kinjo2 (1Graduate School of Life Science, Hokkaido
University, 2Faculty of Advanced Life Science, Hokkaido University, 3Biomedical Research Institute, AIST)
赤外超解像顕微鏡による羽毛内ケラチンタンパク質の分布・配向観察
Orientation-sensitive molecular imaging of feather keratin proteins by an IR super-resolution
micro-spectroscopy
Hirona Takahashi, Masanobu Miyoshi, Takeshi Fujimoto, Makoto Sakai (Faculty of Science, Okayama
University of Science)
マイクロデバイス中の単一酵素活性検出による病態診断法の開発
Development of Novel Disease Diagnosis Platform based on Enzyme Activity Detection atSingle Protein Level
Shingo Sakamoto1, Toru Komatsu1,5, Rikiya Watanabe4,5, Zhang Yi4, Hiroyuki Noji4, Yasuteru Urano1,2,3(1Grad. Sch. Pharm. Sci., The Univ. Tokyo, 2Grad. Sch. Med., The Univ. Tokyo, 3AMED CREST, 4Grad.
Sch. Eng., The Univ. Tokyo, 5JST PRESTO)
Highly sensitive detections of protein-nucleic acid interactions and redox enzyme reactions
using nanostructured electrode
Yasuhiro Mie, Yasuo Komatsu, Yoshiaki Yasutake, Tomohiro Tamura (Bioproduction Res. Inst., AIST)
フォトクロミック分子を利用した蛋白質の高時間分解拡散観測手法
Protein diffusion probed by the transient grating method with a photochromic molecule
Shunki Takaramoto, Yusuke Nakasone, Masahide Terazima (Dep. Chem., Sch. Sci, Kyoto Univ.)
リン酸結合タンパクを封入した水滴チャンバーアレイによるリン酸検出系の高度化
Advanced phosphate detection method by phosphate binding protein encapsulated in droplet
chamber arrays
Akane Kumayama1, Taisuke Inage1, Masayuki Higuchi1, Hiroshi Ueno2, Kazuhito Tabata2,3,
Hiroyuki Noji2, Tomoko Masaike1,4 (1Dept. Appl. Biol. Sci., Grad. Sch. Sci. Tech., Tokyo Univ. of Sci.,
2Dept. Appl. Chem., Sch. Eng., Univ. of Tokyo, 3PRESTO, JST, 4PRESTO, JSTRes. Inst. for Sci and Tech.,Tokyo Univ. of Sci.)– S145 –1Pos411

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細胞内高分子クラウディング状態モデル検証と細胞周期研究への応用
Verification of macromolecule species in intracellular macromolecular crowding condition
application to cell cycle study
Akito Matsui1, Johtaro Yamamoto3, Masataka Kinjo2 (1Graduate School of Life Science, Hokkaido
University, 2Faculty of Advanced Life Science, Hokkaido University, 3AIST)
マクロファージにおける貪食効率の評価のための抗原 free-flow 法の開発
Development of free-flow assay for precise evaluation of phagocytosis efficiency ofmacrophages
Yuya Furumoto1, Yoshiki Nakata1, Toshiki Azuma2, Amane Yoshida2, Masao Odaka3,4,
Akihiro Hattori3,4, Kenji Matsuura3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. &Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res.
Initiatives, Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore)
オンチップ 1 細胞計測におけるマクロファージの同一点連続貪食の履歴効果評価
Hysteresis of single point sequential phagocytoses in macrophages using on-chip single cellmeasurement assay
Toshki Azuma1, Yoshiki Nakata2, Yuya Furumoto2, Amane Yoshida1, Akihiro Hattori3,4,
Kenji Matsuura3,4, Masao Odaka3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng.,
Waseda Univ., 2Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res.
Initiatives, Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore)
オンチップ 1 細胞計測系によるマクロファージの貪食限界の測定
Identifying the maximum size of phagocytosis in macrophages using on-chip single cellmeasurement assay
Amane Yoshida1, Yoshiki Nakata2, Yuya Furumoto2, Toshiki Azuma1, Akihiro Hattori3,4,
Kenji Matsuura3,4, Masao Odaka3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng.,
Waseda Univ., 2Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res.
Initiatives, Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore)
血管内皮細胞のダイナミクス解明に向けた集束光によるゼラチン三次元微細加工技術の評価
Evaluation of photo-thermal three-dimensional gelatin-gel microfabrication technology forclarification of endothelial cells’ dynamics
Hiromichi Hashimoto1, Kento Iida2, Yuki Yamanaka2, Ryuji Takano1, Masao Odaka3,4, Kenji Matsuura3,4,
Akihiro Hattori3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ.,
2Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives,
Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore)
アガロースマイクロチャンバーを用いた多電極アレイによる心筋細胞小細胞群における細胞外電位の測定
Measurement of extracellular potential in small cluster of cardiomyocytes by multi electrodearray with agarose microchamber
Naoki Tadokoro, Tomoyuki Kaneko (LaRc, FB, Hosei Univ.)細胞のマクロな特徴量とラマンスペクトルの間に対応はあるか
Is There A Correspondence between Cellular Macroscopic Quantities and Raman Spectra?
Ken-ichiro F. Kamei1, Koseki J. Kobayashi-Kirschvink1, Yuichi Wakamoto1,2,3 (1Graduate School of Arts
and Sciences, The University of Tokyo, 2Research Center for Complex Systems Biology, The University ofTokyo, 3Universal Biology Institute, The University of Tokyo)
オンチップ 1 点連続貪食計測系によるマクロファージの貪食飽和停止現象の解析
Analysis of neglecting phase in phagocytosis of macrophages using on-chip sequential singlepoint phagocytoses measurement assay
Yoshiki Nakata1, Yuya Furumoto1, Toshiki Azuma2, Amane Yoshida2, Masao Odaka3,4, Kenji Matsuura3,4,
Akihiro Hattori3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda
Univ., 2Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives,
Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore)– S146 –1Pos419

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集束光によるゼラチンの 3 次元微細加工技術を用いた毛細血管形成のダイナミクス計測
Direct observation of blood vein formation dynamics exploiting flexible three-dimensional
gelatin-gel microfabrication technology
Kento Iida1, Yuki Yamanaka1, Hiromichi Hashimoto2, Ryuji Takano2, Masao Odaka3,4, Akihiro Hattori3,4,
Kenji Matsuura3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda
Univ., 2Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives,
Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore)
Model comparison for inverse tissue mechanics of epithelial spreading
Yohei Kondo1, Kazuhiro Aoki1, Shin Ishii2 (1ExCELLS, 2GSI, Kyoto Univ.)
High precision single-molecule techniques for molecular biophysics
Ying Lu, Chun-Hua Xu, Shu-Xin Hu, Ming Li (Institute of Physics, Chinese Academy of Sciences)

2 日目（9 月 16 日（日））／Day 2（Sep. 16 Sun.）
PA 会場（大集会室），PB 会場（南第二集会室），PC 会場（南第三集会室），PD 会場（南第四集会室） ／Room PA (Large Assembly Room), Room PB (2nd South Assembly Room),
Room PC (3rd South Assembly Room), Room PD (4th South Assembly Room)
蛋白質：物性・構造／Protein: Property & Structure
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Substrate analogue-induced folding of staphylococcal nuclease analyzed by statisticalmechanical model
Shunta Furuzawa, Kosuke Maki (Grad. Schl. Sci., Nagoya Univ.)
Analysis of pH, salt and mutation effects on folding of the N-terminal domain of ribosomal
protein L9 using statistical mechanical model
Takuya Mizukami1,2, Kosuke Maki1 (1Schl. Sci., Nagoya Univ., 2Fox Chase Cancer Ctr.)
Theoretical study on the structural stability of alanine dipeptide in supercritical carbon dioxide
Satoshi Nakagawa1, Tatsuki Kataoka1, Tomoya Maeda1, Kazutomo Kawaguchi1, Francesca Ingrosso2,
Marilia Martines-Costa2, Manuel F Ruiz-Lopez2, Hidemi Nagao1 (1Grad. Sch. Nat. Sci. Tech., Kanazawa
Univ., 2Laboratoire de Physique et Chimie Theoriques, UMR CNRS 7019, Universite de Lorraine, 54506
Vandoeuvre-les-Nancy, France)
Ribosome-assisted co-translational folding of a CFTR domain and its deletion mutant studied bymolecular simulations
Suguru Kato, Kazushi Mochizuki, Shoji Takada (Kyoto University)
回転拡散より見積もられるリゾチーム間相互作用に対するホフマイスター効果
Hofmeister effects on lysozyme-lysozyme interaction estimated by rotational diffusion analysis
Akane Kato1, Yudai Katsuki1, Etsuko Nishimoto2 (1Grad. Sch. Bioresour. Bioenviron. Sci., Kyushu Univ.,
2Fac. Agr., Kyushu Univ.)
改良カメレオンモデルによるアデニル酸キナーゼの構造転移の解析
A study on conformational transition of adenylate kinase with an improved chameleon model
Ryota Mori, Mashiho Ito, Tomoki P. Terada, Masaki Sasai (Dept. Appl. Phys., Grad. Sch. Eng., Nagoya
Univ.)A thermodynamic model of amyloid-β protein oligomerization on negatively charged lipid
bilayers
Keisuke Ikeda, Yuuki Sugiura, Minoru Nakano (Graduate School of Medicine and Pharmaceutical
Sciences, University of Toyama)タンパク質フォールディングにおける自由エネルギー面の理論的解析
Theoretical analysis of free energy profile for folding of chignolin
Tomonari Sumi, Kenichiro Koga (Res. Inst. Interdisciplinary Sci., Okayama Univ.)
天然変性ペプチド pKID は高圧力下でフォールドするか
Do an intrinsically disordered peptide, pKID fold under high pressure?
Minoru Kato, Soichiro Kubota, Tubasa Yamamoto (Dept. Applied Chem., Ritsumeikan Univ.)– S147 –2Pos010

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2Pos021Ultra-fast dynamics of simple polyalanine peptides by using nanosecond region fluorescencecorrelation spectroscopy
Supawich Kamonprasertsuk1,2, Hiroyuki Oikawa1,2, Satoshi Takahashi1,2 (1IMRAM, Univ. Tohoku,
2Chem, Grad. Sch. Sci., Univ. Tohoku)
蛋白質-蛋白質相互作用面の二次構造に着目した分類手法の開発
Development of classification method of protein-protein interfaces based on their secondary
structures
Takashi Fujii, Kazuo Fujiwara, Masamichi Ikeguchi (Grad. Sch. of Eng., Soka Univ)
水溶性および膜貫通 β-バレル構造における β-ストランドのねじれ/曲がり
β-strand twisting/bending in soluble and transmembrane β-barrel structures
Nobuaki Kikuchi, Kazuo Fujiwara, Masamichi Ikeguchi (Dept. Bioinfo., Grad. Sch. Eng., Soka Univ.)
アクチンフィラメントの圧電・誘電アロステリーがコフィリンの選択的結合に与える影響
Piezoelectric and dielectric allostery of an actin filament and its effect on binding preference ofcofilin
Jun Ohnuki, Akira Yodogawa, Takato Sato, Taro Q.P. Uyeda, Mitsunori Takano (Dept. of Pure & Appl.
Phys., Waseda Univ.)
The effect of a soft/discontinuity driveshaft on the rotation of F1-ATPase
Shou Furuike1, Naoki Soga2, Yasushi Maki1, Hideji Yoshida1 (1Osaka Med. Col., 2Sch. Eng., Univ. Tokyo)
Investigation on the structural properties of proteins included in non-membraneous granule
droplets
Saya Nakano1,2, Hiroyuki Oikawa1, Satoshi Takahashi1 (1IMRAM, 2Grad. school of Life Science, Tohoku
Univ.)
フェリチン変異体の帯電限界
Charge limit of ferritin mutants
Takumi Kuwata1, Daisuke Sato2, Atushi Kurobe1, Satuki Takebe1, Kazuo Fujiwara1,2,
Masamichi Ikeguchi1,2 (1Grad. Sch. of Eng., Soka Univ., 2Fac. of Sci. and Eng., Soka Univ)
蛍光寿命計測によるアシル CoA 結合タンパク質のフォールディング機構の研究
Folding dynamics of acyl-CoA binding protein revealed by fluorescence lifetime measurements
Koichi Fujii, Motonari Tsubaki, Tetsunari Kimura (Grad. Sch. Sci., Kobe Univ)
Influence of ligand binding on the glass transition temperature
Alexander Krah1, Peter John Bond2,3 (1School of Computational Sciences, Korea Institute for Advanced
Study (KIAS), 2Bioinformatics Institute, A*STAR, 3Department of Biological Sciences, National Universityof Singapore)
回転対称軸周辺における相互作用の摂動による球殻状超分子のアセンブリ・メカニズムへの影響
Change in the assembly mechanism by disrupting of local interactions around symmetry axes ofa spherical shell-shaped supermolecule
Daisuke Sato1, Takumi Kuwata2, Eriko Aoki1, Kazuo Fujiwara1,2, Masamichi Ikeguchi1,2 (1Fac. of Sci. andEng., Soka Univ., 2Grad. Sch. of Eng., Soka Univ.)
ポリミアン優先取込システムに関与する好熱菌由来 PotA の結晶構造解析
Crystal structure of PotA, a membrane-associated ATPase of the spermidine-preferential
uptake system in Thermotoga maritima
Mihoka Amano1, Taichi Naruse1, Keiko Kashiwagi2, Kazuei Igarashi3, Shigeru Sugiyama4 (1Grad. Sch.
Sci., Kochi Univ., 2Fac. Pharm., Chiba Ins. Sci., 3Amine Pharma Res. Ins., 4Fac. Sci. & Tec., Kochi Univ.)
ヨツヒメゾウリムシ由来アルギニンキナーゼの構造学的研究
Structural studies of arginine kinase from Paramecium tetraurelia
Yumeto Otsuka1, Junko Tanaka1, Daichi Yano2, Koji Uda2, Tomohiko Suzuki2, Shigeru Sugiyama2(1Grad. Sch. Sci., Kochi Univ., 2Fac. Sci. & Tec., Kochi Univ.)– S148 –2Pos022

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FABP3 の低分子薬剤に対する分子認識機構の解明
Elucidation of the molecular recognition mechanism of FABP3 in complex with low-molecular
medicines
Junko Tanaka1, Yumeto Otsuka1, Daisuke Matsuoka2, Osamu Hiraoka3, Shigeru Matsuoka4,
Masashi Sonoyama5, Michio Murata2, Shigeru Sugiyama6 (1Grad. Sch. Sci., Kochi Univ., 2Grad. Sch. Sci.,
Osaka Univ. & JST ERATO, 3Sch. Pharm., Shujitsu Univ., 4Fac. Med., Oita Univ, 5Sch. Sci. & Tec., Gumma
Univ., 6Fac.Sci & Tec.,Kochi Univ)
Conformational fluctuations and diffusive dynamics of small proteins
Eiji Yamamoto1, Takuma Akimoto2 (1Dept. System Design Engineering, Keio Univ., 2Dept. Phys., Tokyo
Univ. Sci.)
カロテノイド結合とアミノ酸変異による微生物型ロドプシン TR の熱安定化
Thermostabilization of the microbial rhodopsin TR by carotenoid binding and amino-acidmutation
Tomoki Akiyama1, Keigo Nishikawa3, Sayaka Nemoto4, Satoshi Yasuda2,4,5, Daisuke Umeno6,
Masahiro Kinoshita2, Yuki Sudo3, Takeshi Murata4,7 (1Graduate School of Science and Engineering, Chiba
University, 2Institute of Advanced Energy, Kyoto University, 3Graduate School of Medicine, Dentistry, andPharmaceutical Sciences, Okayama University, 4Graduate School of Science, Chiba University, 5Molecular
Chirality Research Center, Chiba University, 6Graduate School of Engineering, Chiba University,
7PRESTO)
多糖モノオキシゲナーゼ，CBP21 の熱安定性に対する金属イオンの効果
Effects of metal ions on the thermal unfolding of lytic polysaccharide monooxygenase, CBP21
Hayuki Sugimoto, Ayaka Motoyama, Erina Katagiri, Takeshi Watanabe, Kazushi Suzuki (Fac. Agri.,Niigata Univ.)
水棲哺乳類ミオグロビンの分子進化：二つの適応戦略
Tracing evolution of aquatic mammal myoglobins: the two adaptation mechanisms
Yasuhiro Isogai1, Hiroshi Imamura2, Setsu Nakae3, Tomonari Sumi4, Ken-ichi Takahashi3,
Taro Nakagawa3, Antonio Tsuneshige5, Tsuyoshi Shirai3 (1Dept. Pharm. Eng., Toyama Pref. Univ., 2Life
Sci., Ritsumeikan Univ., 3Dept. Comp. Bio-Sci., Nagahama Inst. Bio-Sci. Tech., 4Dept. Chem., Okayama
Univ., 5Dept. Frontier Biosci., Hosei Univ.)
核酸結合蛋白質／Nucleic acid binding proteins

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スピンラベル ESR によるヘテロクロマチンタンパク質 HP1 の動的構造の研究
Structural dynamics of heterochromatin protein HP1 studied by site-directed spin labeling ESR
spectroscopy
Toshiaki Arata3,4, Yuichi Mishima4, Shigeaki Nakazawa5, Kazunobu Sato5, Takeji Takui5,
Toshimichi Fujiwara4, Makoto Miyata3, Isao Suetake1,2,4 (1Koshien Univ., 2Twin Research Center, Osaka
Univ., 3Dept. Biol., Grad. Sch. Sci., Osaka City Univ., 4IPR, Osaka Univ., 5Dept. Chem., Grad. Sch. Sci.,
Osaka City Univ.)
TALE 蛋白質の新規構築法と応用
A simple and accurate construction of TALEs and its applications
Kazuho Ikeda, Yoko Terahara, Yasushi Okada (RIKEN, BDR)
標的 RNA の切断前後の CRISPR-CMR の動力学
The dynamics of CRISPR-CMR before/after the cleavage of targeted RNA
Tomohiro Yamaguchi, Ryo Ohashi, Naoyuki Miyashita (BOST, KINDAI Univ.)
Distinct binding of nuclear proteins to non B-type DNA studied by molecular simulations
Mami Saito, Shoji Takada (Dept Biophysics, Div Biology, Grad School Science, Kyoto University)– S149 –2Pos031

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Theoretical Studies on Stability of RA-VII for Anti-Cancer Agent by Docking and Molecular
Dynamics Simulations
Muhammad Arwansyah Saleh1, Yoh Noguchi2, Takeshi Miyakawa2, Kazutomo Kawaguchi1,
Yukio Hitotsuyanagi3, Satoshi Yokojima3, Ryota Morikawa2, Masako Takasu2, Hidemi Nagao1 (1Divisionof Mathematical and Physical Sciences, Kanazawa University, 2School of Life Sciences, Tokyo University of
Pharmacy and Life Sciences, 3School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)
Combinatorial DNA Binding of Sox/Oct Transcription Factors Studied with Molecular Dynamics
Simulations
Cheng Tan, Shoji Takada (Department of Biophysics, Kyoto University)
蛍光相互相関分光法による単量体/二量体グルココルチコイド受容体の DNA 結合様式解明に向けた研究
Single-oligonucleotide mutated GRE impacts on glucocorticoid receptor binding studied by
FCCS
Daisuke Yamashita1, Sho Oasa2, Jhotaro Yamamoto2,3, Masataka Kinjo2 (1Grad. Shc. of Life Sci.,
Hokkaido Univ., 2Fac. of Adv. Life Sci., Hokkaido Univ., 3Biomed. Res. Inst. AIST)
Comparing Nucleoprotein Filament Assembly of Yeast Dmc1 and Rad51 Recombinases at theSingle-Molecule Level
Wei-Hsuan Lan1, Sheng-Yao Lin1, Wen-Hsuan Chang1, Chih-Yuan Kao2, Peter Chi2,3, Hung-Wen Li1(1Dept. of Chemistry, NTU, 2Inst. of Biochemical Sciences,NTU, 3Inst. of Biological Chemistry, Academia
Sinica)
がん抑制タンパク質ｐ５３の標的探索ダイナミクスの一分子観察
Single-molecule observation of the target search dynamics of a tumor suppressor p53
Yuji Itoh, Agato Murata, Satoshi Takahashi, Kiyoto Kamagata (IMRAM)
Using Single-Molecule Optical Microscopy to Study How PriA Helicase Restarts replication
Han Lin Yang1, Hung-Wen Li1, Min Guan Lin2, Chwan-Deng (David) Hsiao2 (1Dept. Chem, NTU, 2IMB,
Academia Sinica)
核酸／Nucleic acid

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2Pos042二面角系疎視化モデルによる巨大核酸分子の立体構造ゆらぎ―Ｘ線構造の温度因子との比較
Structure fluctuations of large nucleic acids with a corse-grained model in torsional angle
space–A comparison with temperature factors
Shigeru Endo1, Hiroshi Wako2 (1Dept. Phys., Sch. Sci., Kitasato Univ., 2Sch. Socical Sci., Waseda Univ.)
SAXS および SANS プロファイルに基づくオーバーラッピングダイヌクレオソームのモデル構築
Model building of overlapping dinucleosome based on SAXS and SANS profiles
Atsushi Matsumoto1, Hidetoshi Kono1, Rintaro Inoue2, Masaaki Sugiyama2, Yasuhiro Arimura3,
Hitoshi Kurumizaka3 (1QST, 2Kyoto U., 3U. Tokyo)
分子輪投げによる環状 DNA1 分子のトラップ
Trapping of Single Circular DNA Molecules by Molecular Ringtoss
Ken Hirano1, Taiki Dohi1,2, Kyohei Terao2 (1Health Res. Inst., AIST, 2Dep. Eng., Kagawa Univ.)
siRNA を安定化するカチオン性分子と二本鎖 RNA の NMR による相互作用解析
NMR analysis of interactions between dsRNA and cationic oligomers that stabilize smallinterfering RNA
Taiichi Sakamoto1, Rintaro Hara2, Yusuke Maeda2, Takeshi Wada2 (1Fac. Adv. Eng., Chiba Inst. Tech.,
2Fac. Pharm., Tokyo Univ. Sci.)
DNA の構造の揺らぎへの溶媒粘性の影響
Effect of solvent viscosity on configuration fluctuations of DNA
Masato Tanigawa, Takafumi Iwaki (Biophysics, Faculty of Medicine, Oita University)
Structural effect of spermine analogues on inducing DNA compaction
Tomoki Kitagawa, Tkashi Nishio, Yuuko Yoshikawa, Takahiro Kenmotsu, Kenichi Yoshikawa (Faculty ofBiological and Medical Sciences, Doshisha University Laboratory of Life Physics)– S150 –2Pos043

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1-propanol causes reentrant transition on DNA whereas 2-propanol does not: Experimental
verification through single molecular observation
Yue Ma, Yuko Yoshikawa, Koichiro Sadakane, Kenichi Yoshikawa (Grad. Sch. Life Med. Sci, Doshisha
Univ.)
Direct Observation of the Protein-DNA Interaction Using Passive Force-Clamp Optical tweezers
Yen Chan Chang, Hung Wen Li (Department of Chemistry, National Taiwan University, Taipei, Taiwan)
X 線小角散乱法による RecA タンパク質－DNA 複合体フィラメントの構造解析とシミュレーショ
ンモデルとの比較
Structural changes of RecA protein/DNA complex filament promoted by Mg ions analyzed using
SAXS and compared with its models
Satomi Inaba1, Chantal Prevost2, Tsutomu Mikawa3, Hiroshi Sekiguchi1, Masayuki Takahashi4 (1JASRI/
SPring-8, 2CNRS, 3RIKEN BDC, 4Tokyo Inst. Technol.)
DNA インターカレーションと光応答
DNA intercalation and optical response
Satoshi Yokojima (Tokyo University of Pharmacy and Life Sciences)
転写開始複合体における DNA 開裂の粗視化分子シミュレーション研究
DNA Opening in Transcription Initiation Complex Studied by Coarse-grained Molecular
Simulation
Genki Shino, Masahiro Shimizu, Shintaroh Kubo, Toru Niina, Shoji Takada (Dept. of Biophys., Div. of
Bio. Sci., Grad. Sch. of Sci., Univ. of Kyoto)
光照射で構築した DNA マイクロ構造体の熱力学的特性の解析
Analysis of the thermodynamic property of DNA microstructures formed by photo-irradiation
Yu Kasahara, Masahiro Takinoue (Tokyo Institute of Technology/School of Computing/Computer
Science.)
細胞核様 DNA ゲルカプセルの形成のシミュレーション
Numerical simulation of phase separation-based formation of cell nucleus-like DNA gel capsule
Tetsuro Sakamoto, Masamune Morita, Masahiro Takinoue (Department of Computer Science, Tokyo
Institute of Technology)
Heterogeneous chromatin accessibility establishes human nuclear organization
Shin Fujishiro1,2, Masaki Sasai1,2 (1Dept. Comp. Sci. & Eng., Nagoya Univ., 2Dept. Appl. Phys., Nagoya
Univ.)
ヌクレオソーム排他的領域のインスレーター機能の解析
Analysis of insulator function of nucleosome exclusive genome regions
Yuki Matsushima, Hiraku Nishimori, Naoaki Sakamoto, Akinori Awazu (Dept. of Math and Life Science,
Hiroshima Univ.)
過渡的に生じる中間体ヌクレオソームにおけるヒストンテール動態
Histone Tail Dynamics in Transient Intermediate Single Nucleosomes
Takeru Kameda, Yuichi Togashi, Akinori Awazu (Department of Mathematical and Life Sciences,
Hiroshima University)
電子状態／Electronic state

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アミロイド β 凝集の初期過程に対する QM/MM 法を用いた解析
QM/MM analysis of the initial aggregation of amyloid-β peptides
Hiroaki Nishizawa1,2, Hisashi Okumura1,2,3 (1ExCELLS, 2IMS, 3Sokendai)
Relative stability between hydroxide models and oxo models of S1 state of the OEC of PSII by
DFT and beyond DFT methods
Koichi Miyagawa2, Takashi Kawakami1, Hiroshi Isobe3, Mitsuo Shoji4, Shusuke Yamanaka1,
Kazuhiko Nakatani2, Mitsutaka Okumura1, Kizashi Yamaguchi2,5 (1Grad. Sch. Sci., Osaka Univ., 2ISIR,
Osaka Univ., 3Grad. Sch. Nat. Sci. and Tech., Okayama Univ., 4CCS, Tsukuba Univ., 5Inst. Nanosci.
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2Pos057DASH 型クリプトクロムにおける電子移動反応に関する理論的解析
Theoretical Analysis of Electron Transfer Reaction for Cryptochrome-DASH
Ryuma Sato, Makoto Taiji (RIKEN)
光電子放出を用いた TR の電子構造の観測 2：RxR との比較
Electronic structure of a film with TR observed by technique using photoelectron emission 2:
Comparison with RxRDaisuke Sano1, Yuki Takeda1, Tomoki Akiyama1, Kanae Kanahara2, Takeshi Murata1,3, Yuki Sudo2,
Hisao Ishi1,3,4 (1GSSE Chiba Univ., 2GSMP Okayama Univ., 3MCRC Chiba Univ., 4CFS Chiba Univ.)
高感度紫外光電子分光を用いたリゾチーム薄膜のギャップ内準位の観測
Gap state of lysozyme thin film observed by high-sensitivity UV photoelectron spectroscopy
Ichiro Ide1, Daisuke Sano1, Shintaro Maruyama1, Yuya Tanaka3, Takeshi Murata2, Hisao Ishii4 (1Grad.
Sch. Sci. Eng., Univ. Chiba, 2Grad. Sch. Sci. Eng, Chi. Res. Cen., Univ. Chiba, 3Grad. Sch. Sci. Eng., Cen.
Fro. Sci., Univ. Chiba, 4Grad. Sch. Sci. Eng., Fro. Sci. Cen., Chi. Res. Cen., Univ. Chiba)
水・水和／電解質／Water & Hydration & Electrolyte

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各種溶質周囲の水分子ダイナミクスの分子動力学計算と解析
MD simulations and analysis of hydration dynamics around several types of solute molecules
Takuya Takahashi, Kota Kasahara, Ryoi Ashida, Nobuya Hasegawa, Daigo Itsuji, Tomomi Kura (Collegeof Life Science, Ritsumeikan University)
細胞混雑中の蛋白質間相互作用に及ぼす代謝物とイオンの影響:分子動力学法による理論的研究
Influence of metabolites and ions on the protein-protein interactions in cellular crowding:
Theoretical study with MD simulations
Isseki Yu1,2, Michael Feig3, Yuji Sugita2 (1Maebashi Institute of Technology, 2RIKEN Theoretical
Molecular Science Lab., 3Michigan State University)
機械学習アプローチによる物理化学量の予測
Classification and prediction of physicochemical properties by machine-learning approach:molecular dynamic study of hydration water
Taku Mizukami1, Viet Cuong Nguyen3, Tien Lam Pham2, Heui Chi Dam2 (1JAIST, Materials, 2JAIST,
Knowledge, 3HPC.Inc)
MDM2-p53NTD と MDM2-MIP の結合自由エネルギーに見られる大きな差の物理起源
Physical origin of the large difference between MDM2-p53NTD and -MIP complexes in binding
free energy
Tatsuya Yamada1, Tomohiko Hayashi1, Naohiro Kobayashi2, Hiroshi Yanagawa3, Masato Katahira1,
Takashi Nagata1, Masahiro Kinoshita1 (1Inst. of Adv. Energy, Kyoto Univ., 2Inst. for Protein Res., Osaka
Univ., 3IDAC Theranostics, Inc.)
溶媒の種類が蛋白質の安定構造に及ぼす効果
Effects of solvent species on the stabilized structure of a protein
Tomohiko Hayashi1, Masao Inoue1, Satoshi Yasuda1,2,3, Emanuele Petretto4, Tatjana Skrbic4,
Achille Giacometti4, Masahiro Kinoshita1 (1Inst. Adv. Energ., Kyoto Univ., 2Grad. Sch. Sci., Chiba Univ.,
3MCRC, Chiba Univ., 4Dept. of Molecular Sciences and Nanosystems, Venezia Univ.)
セロビオースとマルトースの水への溶解度の大きな差に関する統計熱力学
Statistical thermodynamics on the large difference between maltose and cellobiose in terms ofsolubility in water
Simon Hikiri1,2, Tomohiko Hayashi2, Mitsunori Ikeguchi3,4, Masahiro Kinoshita2 (1Grad. Sch. of Sci.,
Chiba Univ., 2Inst. of Adv. Energy, Kyoto Univ., 3Grad. Sch. of Med. Life Sci., Yokohama City Univ.,
4RIKEN, MIH)

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The analysis of Housekeeping Gene Expression Variations During iPS Reprogramming Process
Yulia Panina, Arno Germond, Tomonobu Watanabe (RIKEN BDR)
エピジェネティックな状態変化と遺伝子相互作用が細胞のがん化に及ぼす影響のランドスケープ理論による解析Landscape analyses of coupled dynamics of epigenetic state change and gene interaction incarcerization
Yutaro Kameyama, Masaki Sasai (Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.)
生体膜・人工膜／Biological & Artificial membrane: Structure & Property

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細胞膜アンカーを目指した α ヘリックス型ペプトイドの合成
Synthesis of an α-helix peptoid for cell-membrane anchoring
George Mogami, Wato Oba, Masaya Yamamoto (Grad. Sch. Eng., Tohoku Univ.)
Implicit Solvent Coarse-Grained Lipid Model for Molecular Simulations of Multicomponent
Membrane Systems
Diego Ugarte, Shoji Takada (Dept. Biophysics, Div. Biology, Graduate School of Science, Kyoto
University)
細胞模倣系における蛍光相関分光法による分子拡散測定
Molecular diffusion in cell-mimicking system measured by fluorescence correlation
spectroscopy
Chiho Watanabe, Yuta Kobori, Miho Yanagisawa (Tokyo Univ. Agri. Technol.)Single molecule analysis of transport protein using small liposome with size uniformity
Naoki Soga1, Rikiya Watanabe1,2, Hiroyuki Noji1 (1Dept. of Appl. Chem., The Univ. of Tokyo, 2AMEDPRIME, JST)
高速 AFM を用いた光受容体ロドプシンクラスターとトランスデューシンとの相互作用観察
Observing the interaction between rhodopsin cluster and transducin by high-speed AFM
Yasushi Tanimoto1, Hayato Yamashita2,3, Kento Nomura2, Masayuki Abe2, Fumio Hayashi4,
Kenichi Morigaki1,5 (1Biosignal research Center, Univ Kobe, 2Grad. Sch. Eng. Sci., Univ Osaka, 3PRESTO,
JST, 4Grad. Sch. Scie, Univ. Kobe, 5Grad. Sch. Agr., Univ. Kobe)
全反射赤外分光法によるＧタンパク質共役受容体-リガンド間相互作用の解析
Investigation of ligand-protein interaction in a G protein-coupled receptor via ATR-FTIR
spectroscopy
Hisao Tsukamoto1,2, Yuji Furutani1 (1Institute for Molecular Science, 2PRESTO, JST)
細胞骨格封入巨大リポソームの繰返し屈伸運動
Repetitive stretching of cytoskeleton-encapsulating giant liposomes
Masahito Hayashi2, Shunsuke Tanaka1, Masayoshi Nishiyama3, Taro Toyota4, Kingo Takiguchi1 (1Grad
Sch of Sci, Nagoya Univ, 2CBS, RIKEN, 3Dept of Phys, Kindai Univ, 4Graduate School of Arts andSciences, The University of Tokyo)
アガロースマイクロチャンバー内でのマクロファージの運動の観察
Observation of Macrophage Migration in Agarose Microchamber
Nami Morizono, Tomoyuki Kaneko (LaRC, FB, Hosei Univ)
In vitro reconstitution system for traveling waves of PIP3
Hitomi Matsubara1,2, Satomi Matsuoka1,2, Masahiro Ueda1,2 (1Grad. Sch. FBS., Univ. Osaka, 2RIKEN)
クラミドモナスの機械反応における TRP11 の役割
Roles of TRP11 in Mechanoresponces in Chlamydomonas
Kosuke Anzai1, Akiko Yoshida1, Megumi Yoshida1, Ken-ichi Wakabayashi2, Kenjiro Yoshimura1 (1Dept.
Machinery & Control Systems., Shibaura Inst. Technol., 2Inst. Innovative Res., Tokyo Inst. Technol.)– S153 –2Pos076

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ナノポアによる一分子 AND ゲートの構築とリポソームへの搭載
Single molecule AND gate with a biological nanopore integrated into a liposome
Ping Liu, Keisuke Shimizu, Masayuki Ohara, Ryuji Kawano (Tokyo University of Agriculture andTechnology)
A simple method for single ion channel recordings
Kota Kaneko1, Huimin Ma1, Minako Hirano2, Toru Ide1 (1Okayama University, 2The Graduate School for
the Creation of New Photonics Industries)
イオンチャネルの特性の改変
Modifications of K+ channel property
Tomoya Ishido1, Toru Ide1, Minako Hirano2 (1Okayama University, 2GPI)
ステロールによる膜張力を介した KcsA カリウムチャネル活性の制御
Regulation of the activity of the KcsA potassium channel via bilayer tension-mediated sterol
actionMasayuki Iwamoto, Shigetoshi Oiki (Dept. Mol. Physiol. Biophys., Univ. Fukui Facul. Med. Sci.)
ATP 合成阻害時の細胞内ミトコンドリアの膜電位モニタリング
Monitoring of mitochondrial membrane potential upon addition of oligomycin
Emika Shida, Yshihiro Ohta (Tokyo University of Agriculture and Technology)
多剤輸送担体 EmrE の多剤認識における熱力学
Thermodynamics of multidrug recognition in multidrug transporter, EmrE
Kazumi Shimono1,2, Keisuke Matsuda2, Shoko Suzuki2, Kaho Yajima2, Sakiyo Yamamoto2,
Seiji Miyauchi2 (1Fac. Pharm. Sci., Sojo Univ., 2Fac. Pharm. Sci., Toho Univ.)
移動性細胞における PI(3,4,5)P3 の非対称分布を安定化する PTEN-PI(4,5)P2 ポジティブフィード
バック機構
PTEN-PI(4,5)P2 positive feedback mechanism for stabilizing asymmetric PI(3,4,5)P3 localizationin migrating cell
Daisuke Yoshioka1,3, Hiroyasu Koteishi3, Daichi Okuno3, Satomi Matsuoka3, Toru Ide4,
Masahiro Ueda1,2,3 (1Grad. Sch. of Sci., Osaka Univ., 2Grad. Sch. of Front. Biosci., Osaka Univ., 3RIKEN,
4Grad. Sch. of Nat. Sci. and Tech., Okayama Univ.)
Simulation of Shape Transformation of Vesicle Including Particles
Hibiki Itoga1, Ryota Morikawa1, Tsuyoshi Ueta2, Takeshi Miyakawa1, Yuno Natsume3, Masako Takasu1(1Tokyo Univ. Pharm. Life Sci., 2Jikei Univ., 3J. Women's Univ.)
行動／Behavior

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機械刺激がゾウリムシの逃走反応を誘導するしくみ
Molecular mechanism of escape response induced by mechanical stimulation in Paramecium
Mutsumi Kawano1, Ayaka Seto1, Takashi Tominaga2, Masaki Ishida3, Manabu Hori1 (1Fac. Sci,
Yamaguchi Univ., 2Inst Neurosci, Tokushima BUNRI Univ., 3Sch. Sci. Edu., Nara Univ. Edu.)
三次元空間における真正粘菌変形体の管ネットワーク形成
Tubular network formation in three dimensional space by the true slime mold
Seiji Takagi (Future University Hakodate)
光生物学：視覚・光受容／Photobiology: Vision & Photoreception

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珪藻および渦鞭毛藻由来の真核生物型 H+ポンプロドプシンの機能・光化学的解析
Characterization of eukaryotic H+ pumping rhodopsins from the diatom Pseudo-nitzschia granii
and dinoflagellate Oxyrrhis marina
Masuzu Kikuchi1, Susumu Yoshizawa2, Akimasa Kaneko1, Keiichi Kojima1,3, Yuki Sudo1,3 (1Fac. of
Pharm. Sci., Okayama Univ., 2AORI, UTokyo., 3Grad. Sch. of Med. Dent Pharm. Sci., Okayama Univ.)– S154 –2Pos087

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スチレンマレイン酸 (SMA) コポリマーを用いた微生物型ロドプシンの可溶化とその分光学的解析Solubilization and spectroscopic analysis of microbial rhodopsins in styrene-maleic acid (SMA)
copolymers
Tetsuya Ueta1, Kanae Kanehara1, Keiichi Kojima1,2, Tomoya Hino3, Shingo Nagano3, Yuki Sudo1,2 (1Fac.
of Pharm. Sci. Okayama Univ., 2Grad. Sch. of Med. Dent. Pharm. Sci., Okayama Univ., 3Grad. Sch. ofEng., Tottori Univ.)
光駆動ナトリウムポンプ KR2 における Ser70 の役割
Role of Ser70 for transport activity of a light-driven sodium ion pump
Rei Abe-Yoshizumi1, Aki Nemoto1, Keiichi Inoue1,2,3, Hideki Kandori1 (1Nagoya Inst. Tech., 2ISSP Univ.
of Tokyo, 3JST PRESTO)
光駆動 SO42-輸送体（SyHR）のアニオン輸送と選択性への塩基性アミノ酸残基の役割
Role of basic amino acid residues on the anion transport and its selectivity in a light-driven
SO42- transporter SyHR
Masaki Nakama1, Keiichi Kojima1,2, Marie Kurihara2, Susumu Yoshizawa3, Yuki Sudo1,2 (1Fac. of
Pharm. Sci. Okayama Univ, 2Grad. Sch. of Med. Dent. & Pharm. Sci. Okayama Univ, 3AORI, UTokyo)
出芽酵母を用いたアニオンチャネルロドプシンの発現と分光学的解析
Expression and spectroscopic analysis of anion channelrhodopsins using a eukaryotic yeast,
Saccaromyces cerevisiae
Ryota Ono1, Taro Yamanashi2, Keiichi Kojima1,2, Hisao Moriya3, Yuki Sudo1,2 (1Div. of Pharm. Sci.,
Okayama Univ., 2Grad. Sch. of Med., Dent. & Pharm. Sci., Okayama Univ., 3Res. Core for Interdiscip. Sci.,
Okayama Univ.)
海洋性真核藻類 Guillardia theta における 44 種類の微生物型ロドプシン様タンパク質の遺伝子発現解析
Gene expression analysis of 44 microbial rhodopsin-like proteins from marine algae Guillardia
theta
Yumeka Yamauchi1, Masae Konno1,2, Keiichi Inoue1,3,4, Hideki Kandori1,2 (1Grad. Sch. Eng., NIT,
2OBTRC, NIT, 3ISSP, Univ. Tokyo, 4PRESTO, JST)
円石藻ウイルス由来のヘリオロドプシンの分子物性解析
Molecular characterization of heliorhodopsin from Emiliania huxleyi virus
Ritsu Mizutori1, Masae Konno1,2, Keiichi Inoue1,2,3,4, Oded Beja5, Hideki Kandori1,2 (1Grad. Sch. Eng.,
NIT, 2OBTRC, NIT, 3ISSP, Univ. Tokyo, 4PRESTO, JST, 5Technion-Israel Inst. Tech.)
Mutational analysis of amino acid residues surrounding the electron-transferring terminal Trp ofplant (6-4) photolyase
Yuhei Hosokawa1, Ryuma Sato2, Shigenori Iwai1, Junpei Yamamoto1 (1Grad. Sch. Eng. Sci., Univ. Osaka,
2Riken)Analysis of binding of light-harvesting secondary chromophore to animal and plant (6-4)
photolyase
Ayaka Morimoto, Kumar Rajiv, Yuhei Hosokawa, Yuma Terai, Shigenori Iwai, Junpei Yamamoto (Grad.
Sch. Eng., Univ. Osaka)
過渡回折格子法を用いた orange carotenoid protein の光反応ダイナミクスの研究
Study on photoreaction dynamics of orange carotenoid protein using transient grating method
Takatoshi Ohata, Yusuke Nakasone, Masahide Terazima (Grad. Sch. Sci., Univ. Kyoto)
ビリベルジン結合型シアノバクテリオクロムの遠赤／橙色光変換過程での構造変化の検出
Detection of structural change during far-red/orange reversible photoconversion of biliverdinbinding cyanobacteriaochrome
Yuka Takeda, Keiji Fushimi, Rei Narikawa (Grad. Sch. Integrated Science and Technology, Univ.
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Application of electron spin polarization imaging method to obtain geometries of photoinduced
charge-separated states in cryptochrome
Hiroki Nagashima1, Misato Hamada2, Takashi Tachikawa1,2, Tatsuya Iwata3, Hideki Kandori4,
Till Biskup5, Stefan Weber5, Yasuhiro Kobori1,2 (1Mol. PhotoSci., Kobe Univ., 2Grad. Sch. Sci., Kobe
Univ.,, 3Facul. Pharmaceutical Sci., Toho Univ., 4Grad. Sch. Eng., Nagoya Inst. Tech.,, 5Inst. Phys. Chem.,
Albert-Ludwigs-Univ. Freiburg)
Rc-PYP(K72Q)を用いた複合体形成過程の解析
Elucidation of the complex formation process using Rc-PYP mutant K72Q
Natsuki Oka, Yoichi Yamazaki, Yugo Hayashi, Hironari Kamikubo (Nara Institute of Science andTechnology)
膜脂質環境が G タンパク質トランスデューシンの活性化効率に及ぼす影響
The effect of lipid environment of outer segment membranes on the activation of photoreceptor
specific G protein, Transducin
Kyoko Kadomatsu1, Keiji Seno2, Yuki Ito1, Satoru Kawamura1, Shuji Tachibanaki1 (1Grad. Sch. of
Frontier Biosci., Osaka Univ., 2Department of Biology, Faculty of Medicine, Hamamatsu University Schoolof Medicine)
色覚視物質の結晶構造解析に向けたユニークな戦略
Unique approaches towards cone opsin crystallization
Kota Katayama, Hideki Kandori (Grad. Sch. Eng., Nagoya Inst. Tech.)
フーリエ変換赤外分光法によるロドプシンと錐体視物質の発色団／蛋白質相互作用の比較
Comparison of chromophore/protein interaction between rhodopsin and cone pigment using
Fourier transform infrared spectroscopy
Naoto Noguchi1, Takahiro Yamashita1, Yoshinori Shichida2, Yasushi Imamoto1 (1Kyoto University,
2Ritsumeikan University)
網膜桿体細胞内円盤膜上の脂質-光受容タンパク質の秩序形成の数理モデル
A mathematical model of pattern formation of lipid-photoreceptor proteins on disk membranesof retinal cells
Yukito Kaneshige1, Akinori Awazu1, Hiraku Nishimori1, Humio Hayashi3, Kenichi Morigaki2,
Taishi Tanimoto2 (1Grad. Sci. Univ. Hiroshima, 2Grad. Agri. Univ. Kobe, 3Grad. Sci. Univ. Kobe)
バクテリオロドプシンにおける 1 段階目のプロトン移動を対象とした大規模量子分子動力学シ
ミュレーション
Large-scale quantum-mechanical molecular dynamics simulations for the primary protontransfer in bacteriorhodopsin
Junichi Ono1, Minori Imai2, Yoshifumi Nishimura1, Hiromi Nakai1,2,3 (1RISE, Waseda Univ., 2Grad. Sch.
of Adv. Sci. & Eng., Waseda Univ., 3ESICB, Kyoto Univ.)
大規模励起状態計算手法の開発と光活性イエロータンパク質に対する応用研究
Development of large-scale excited-state calculation method and applied research on
photoactive yellow protein
Nana Komoto1, Takeshi Yoshikawa1, Junichi Ono2, Hiromi Nakai1,2,3 (1Grad. Sch. of Adv. Sci. & Eng.,
Waseda Univ., 2RISE, Waseda Univ., 3ESICB, Kyoto Univ.)
その他／Miscellaneous topics

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ポリリジン残基の付加は、DNA オリガミへの SNAPf 融合蛋白質の結合速度を向上させる
Poly-lysine tag increase the binding rate of SNAPf-fused protein to DNA origami
Kodai Fukumoto1, Yuya Miyazono2, Hisashi Tadakuma1, Yoshie Harada1 (1IPR, Osaka Univ., 2Grad. Sch.
Front. Sci., Univ. Tokyo)– S156 –2Pos106

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希少糖生産に関わる単糖間異性化反応の熱力学的研究
Thermodynamic investigation on the isomerization of monosaccharides for rare sugar
production
Akihide Yoshihara, Mitsuki Murakami, Ryoko Iwata, Taro Kozakai, Kimi Fujiwara,
Kazuhiro Fukada (Fac. Agric., Kagawa Univ.)
試料環境による eGFP の電子誘起変換の依存性
The environmental dependence of the "electron-induced" conversion of eGFP
Koki Matsui, Keiichirou Akiba, Hiroki Minoda (TUAT)
A model for analyzing phenomena in multicellular organisms with multivariable polynomials:
Polynomial-life model
Hiroshi Yoshida (Grad. Schools of Math. & Systems Life Sci. Kyushu Univ.)
The ancient gods of the modern cytoskeleton
Caner Akil1,2, Robert C. Robinson1,2,3 (1Institute of Molecular and Cell Biology, A*STAR (Agency for
Science, Technology and Research), 2Department of Biochemistry, Yong Loo Lin School of Medicine,National University of Singapore, 3Research Institute for Interdisciplinary Science, Okayama University)
Structural characterization of ALP37, a potential chromosome segregating ParM
Samson Ali1,2, N Akihiro3, D Popp1, Robert C. Robinson1,2,4 (1Institute of Molecular and Cell Biology,
2National University of Singapore, NUS, Yong Loo Lin School of Medicine, 3Nagoya University Graduate
School of Science, Structural Biology Research Center and Division of Biological Sciences, 4ResearchInstitute for Interdisciplinary Science (RIIS), Okayama University)
分子モーター／Molecular motor

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アクトミオシンの運動を利用した抗原抗体反応の促進
Acceleration of antigen-antibody reaction by actomyosin motility
Shohta Takamori1, Kaito Kobayashi1, Takashi Ishiguro2, Hajime Honda1 (1Nagaoka Univ. Tech., 2Taiyo
Yuden Co., Ltd.)
水晶振動子微量天秤によるアクチン繊維とミオシンの見かけの質量変化
QCM revealed the changes of apparent mass of actin filaments and myosin molecules
Kaho Yokomuro1, Shota Takamori1, Kazuya Soda1, Takashi Ishiguro2, Hajime Honda1 (1Nagaoka Univ.
Tech., 2Taiyo Yuden Co., Ltd.)Single-molecule fluorescence imaging analysis of Serratia marcescens ChitinaseA (SmChiA)
Trp-active mutant
Akasit Visootsat1,2, Paul Vignon3, Akihiko Nakamura1,2, Ryota Iino1,2 (1SOKENDAI, 2Institute for
Molecular Science, 3ParisTECH)
DNA ナノチューブに沿って移動する生体分子モーターの設計
Engineering motor proteins to move along DNA nanotubes
Ryota Ibusuki1, Akane Furuta2, Tatsuya Morishita1, Kazuhiro Oiwa1,2, Hiroaki Kojima2, Ken'ya Furuta2(1Graduate School of Biological Science, University of Hyogo, 2Adv. ICR. Res. Ins., NICT. Kobe)
高速 AFM を用いた DNA terminase の構造と動態の研究
Study of structure and dynamics of DNA terminase using high-speed AFM
Hirotaka Ariyama, Toshio Ando (WPI-NanoLSI, Kanazawa Univ.)
プロセッシブダイニンモータードメインのマイクロ秒時間分解能、ナノメーター位置決定精度１
粒子トラッキング
Single-particle tracking of motor domain of a processive dynein at microsecond time resolution
and nanometer localization precision
Jun Ando1,2, Tomohiro Shima3, Akihiko Nakamura1,2, Akasit Visootsat1,2, Mayuko Yamamoto1,
Takahide Kon4, Ryota Iino1,2 (1IMS, NINS, 2SOKENDAI, 3Univ. Tokyo, 4Osaka Univ.)– S157 –2Pos2072Pos208

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中間鎖点変異による外腕ダイニンモーター活性の低下
A point mutation in intermediate chain gene reduces motor activity of outer-arm dynein
Yusuke Kondo1, Tomoka Ogawa1, Emiri Kanno2, Masafumi Hirono3, Takako Minoura2, Ritsu Kamiya2,
Toshiki Yagi1 (1Dept. Biol. Sci., Pref. Univ. Hiroshima, 2Dept. Biol. Sci., Chuo Univ, 3Dept. of Front. Life
Sci., Hosei Univ)
単一軸糸ダイニンを欠失した新規クラミドモナス変異株９種の単離と解析
Identification of nine kinds of Chlamydomonas mutants missing single axonemal dynein heavy
chainsTomohiro Komatsu, Yusuke Kondo, Natsuki Tanaka, Kohei Fujimoto, Kazuhiro Takeshima (Dept. Life
Sci., Pref. Univ. of Hiroshima)
X 線繊維回折法で明らかにするクラミドモナス鞭毛軸糸構成要素の Ca2+濃度依存的らせん対称性の変化
Ca2+ dependent changes in helical symmetry of axonemal components of Chlamydomonas
flagella studied by X-ray fiber diffraction
Kazuhiro Oiwa1, Hiroyuki Iwamoto2 (1Natl. Inst. Info.Commun.Technol., 2Japan Sync. Rad. Res. Inst.,
SPring-8)
Behavior of polymerized microtubules interacted with dyneins still attached on a doublet
microtubule detected by laser tweezers
Takashi Fujiwara1, Chikako Shingyoji1, Hideo Higuchi2 (1Dept. Biol. Sci., Grad. Sch. Sci., The Univ.
Tokyo, 2Dept. Phys., Grad. Sch. Sci., The Univ. Tokyo)
細胞質ダイニンの二足歩行メカニズムに関するマルコフ状態モデリング
Bi-pedal motions of cytoplasmic dynein via Markov state modeling
Shintaroh Kubo, Shoji Takada (Takada Lab., Grad. Sch. of Sci., Kyoto Univ.)
高速原子間力顕微鏡により観察されたクラミドモナス軸糸ダイニンの調整機構
High-speed atomic force microscopic observations on demembranated Chlamydomonas
axonemes and dynein arms
Kenta Ishibashi1,2, Kazuhiro Oiwa2,3 (1Grad. Sch. Frontier Biosci., Osaka Univ, 2Advanced ICT Inst.,
NICT, 3Grad. Sch. Sci., Univ. Hyogo)
Step sizes and rate constants of single-headed cytoplasmic dynein
Yoshimi Kinoshita1, Taketoshi Kambara1,2, Kaori Nishikawa1, Motoshi Kaya1, Hideo Higuchi1 (1Dept.
Phys., Univ of Tokyo, 2RIKEN QBiC)
DNA-templated assembly of axonemal outer arm dynein complexes in vitro
Yuka Matsuda1, Akane Furuta2, Hiroaki Kojima2, Kazuhiro Oiwa1,2, Ken’ya Furuta2 (1Grad. Sch. Sci.,
Univ Hyogo, 2Adv ICT Res Ins, NICT)
クライオ電子顕微鏡画像解析により明らかになった細胞質ダイニンの新たな歩行パターン
Cryo-EM observation of stepping patterns of cytoplasmic dynein on microtubules with new
freezing conditions
Riko Kanazawa1, Hiroshi Imai1, Takuma Shioi1, Rieko Shimo1, Ryousuke Yamamoto1, Kaoru Mitsuoka2,
Takahide Kon1 (1Dep. Boil. Grad. Sch. of Sci. Osaka Univ, 2Res. Ctr. UVHEM, Univ. Osaka)
細胞質ダイニンが運動活性を示す蛍光 ATP の合成
Synthesis of fluorescent ATP to elucidate coordination of multiple ATPase sites in cytoplasmic
dyneinKaribu Sakai, Tomotaka Komori, Tomohiro Shima, Sotaro Uemura (Dep. of Bio. Sci., Grad. Sch. of Sci.,
The Univ. of Tokyo)
粘弾性溶液中におけるキネシンによる微小管の運動についての研究
Investigation of motility of microtubules driven by kinesins in viscoelastic media
Masayuki Furukawa1, Taikopaul Kaneko1, Farhana Tammana1, Hirohumi Shintaku2, Hidetoshi Kotera2,
Ryuji Yokokawa1 (1Kyoto Univ. Micro Eng., 2Riken)
糸状菌キネシンへの１残基置換が低温適性をもたらす代わりに熱安定性を損なう
Single amino acid substitution for the fungal kinesin offers possible cold-adaptation but impairs
thermal stability
Youske Shimizu, Toru Togawa, Shigeru Chaen (Dept. Biosciences, Nihon Univ.)– S158 –2Pos219

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細胞分裂に関わるキネシン 5 の高速一分子観察
High-speed single molecule observations of the stepping motion of mitotic kinesin-5
Taiga Yamada, Kohei Matsuzaki, Michio Tomishige, Yoko Sakai (Aoyamagakuinuniversity Tomishigelab.)
遺伝性痙性対麻痺を引き起こす変異型ヒト KIF1A の神経細胞内 Run-time 分布
Run-time distributions of human KIF1A mutants in hippocampal neurons in relation to hereditary
spastic paraplegia
Shiori Matsumoto1, Shinsuke Niwa2, Kumiko Hayashi1,3 (1Dep. Appl. Phys., Grad. Sch. of Eng., Tohoku
Univ., 2FRIS, Tohoku Univ., 3PRIME, AMED)
キネシン 1 二量体の前頭部における微小管からの解離抑制の直接観察
Direct observation of the suppression of the leading head of kinesin-1 dimer from detachmentfrom microtubule
Kohei Matsuzaki, Michio Tomishige (Dept. Math. Phys., Col. Sci. Eng., Aoyama Univ.)
Selective nano-patterning of kinesin motor-proteins and its effect on collective motion of
microtubules
Tamanna Ishrat Farhana, Taikopaul Kaneko, Ryuji Yokokawa (Dep. of microengineering, Kyoto
university)
Does giraffe kinesin move faster than mouse?
Taketoshi Kambara1, Yasushi Okada1,2 (1RIKEN BDR, 2Univ of Tokyo, Grad. Sci.)
Photoregulation of kinesin Eg5 using photochromic compound composed of azobenzene andspiropyran which forms three isomerization states
Md Alrazi Islam, Kei Sadakane, Shinsaku Maruta (Soka University)
2 つのアゾベンゼンを持つ新規フォトクロミック阻害剤を介したキネシン Eg5 の光制御
Photo-regulation of mitotic kinesin Eg5 using a novel photochromic inhibitor composed of two
azobenzene
Kei Sadakane, Kenichi Taii, Alrazi M.D. Islam, Shinsaku Maruta (Dept. Bioinfo., Soka Univ.)
Photo-control of Ras GDP-GTP exchange using the peptide modified with spiropyran derivative
Kenichi Taii, Nobuyuki Nishibe, Shinsaku Maruta (Dept. of Bioinfo, Grad. Sch. of Engin, Soka Univ.)
鞭毛軸糸再構築系における微小管の繰り返し座屈運動の観察
Repetitive buckling of microtubules driven by axonemal dynein arrays reconstituted on a
microtubule
Misaki Sagawa1, Misaki Shiraga2, Hitoshi Sakakibara3, Kazuhiro Oiwa3 (1Sch. Sci, Univ. Hyogo, 2Grad.
Sch. Sci, Univ. Hyogo, 3Adv. ICT Res. Inst., NICT)
Identifying actin regulators from complex cellular lysates through profilin pull down
Dennis Mweti Mwangangi1,2, R. Robinson1,2,3, S. Widyawillis1 (1Institute of Molecular and Cell Biology,
A*STAR, 2Department of Biochemistry, Yong Loo Lin School of Medicine, National University ofSingapore, 3Research Institute for Interdisciplinary Science (RIIS), Okayama University)
細胞生物的課題／Cell biology

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Cellular localization of SAS6-L, a paralog of a flagellar basal body protein that self-assembles
into a 9-fold symmetrical structure
Yuki Nakazawa1, Masahito Nagao1, Akira Noga2, Manuel Hilbert3, Michel O. Steinmetz3,
Masafumi Hirono1 (1Dept. of Frontier Biosci., Hosei Univ., 2Dept. of Biosci., Grad. Sch. Sci, Univ. Tokyo,
3PSI)
ビブリオ菌の極べん毛本数制御における FlhG の ATPase モチーフおよび ATPase 活性の役割
The role of ATPase motif and ATPase activity of FlhG in flagellar number regulation at cell poleof Vibrio alginolyticus
Yoshino Imura, Seiji Kojima, Michio Homma (Grad. Sch. Sci., Univ. Nagoya)– S159 –2Pos303

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ビブリオ菌細胞の極に局在するタンパク質 FlhF による極べん毛形成促進機構の解析
Role of FlhF localized at cell pole on initiating the polar flagellar formation of Vibrio alginolyticus
Yuna Inoue, Seiji Kojima, Michio Homma (Division of Biological Science, Graduate School of Science,
Nagoya University)
ナトリウムイオン透過における、べん毛モーター固定子タンパク質 PomA のペリプラズムループ
領域の構造機能解析
Structural and functional characterization of periplasmic loop regions of PomA, a stator proteinof flagellar motor, in sodium ion flux
Hiroto Iwatsuki1, Masayo Iwaki2, Hiroyuki Terashima1, Seiji Kojima1, Hideki Kandori2, Michio Homma1(1Div. Biol. Sci., Grad. Sch. Sci., Nagoya Univ., 2Grad. Sch. Eng., Nagoya Inst. Tech)
細菌べん毛モーター形成の中心となる超分子膜構造体 MS リングの形成メカニズムの解明
Assembly mechanism of supramolecular membrane structure of bacterial flagellar MS-ringcomposed of FliF
Keiichi Hirano, Hiroyuki Terashima, Michio Homma (Div. Biol. Sci., Grad. Sch. Sci., Nagoya Univ)
細菌べん毛 III 型分泌装置のある構成因子は翻訳後多段階プロセシングを受ける
A component of the bacterial flagellar type III secretion apparatus receives multistep posttranslational processing
Yohei Hizukuri1, Takehiro Suzuki2, Kosuke Terushima1, Naoshi Dohmae2, Yoshinori Akiyama1 (1Inst.
Front. Life Med. Sci., Kyoto Univ., 2Center Sust. Res. Sci., RIKEN)
バクテリアべん毛輸送ゲート複合体の構造機能解析
Structural and functional analyses of the bacterial flagellar type III export gate complex
Miki Kinoshita1, Tomoko Miyata1, Akihiro Kawamoto2, Takayuki Kato1, Keiichi Namba1,3,
Tohru Minamino1 (1Grad. Sch. Frontier Biosci, Osaka Univ., 2IPR, Osaka Univ., 3RIKEN Quantitative
Biology Center)
海洋性ビブリオ菌の極べん毛本数制御機構における FlhG の N 末端領域の解析
Role of N-terminal region of FlhG in polar flagellar number regulation in Vibrio alginolyticus
Seiji Kojima, Akira Mizuno, Michio Homma (Div. Biol. Sci., Grad. Sch. Sci., Nagoya Univ.)
Quantitative observation of CheY-GFP binding to a flagellar motor in the presence of externalload by electrorotation
Kenta Morishima, Yong-Suk Che, Akihiko Ishijima, Hajime Fukuoka (Grad. Sch. Front Biosciences,
Osaka Univ)
Difference on chemotaxis response of E.coli derived from the dependency of flagellar motor
Akinori Nagataki, Yong-Suk Che, Akihiko Ishijima, Hajime Hukuoka (Grad. Sch Front Biosciences,
Osaka Univ.)
モーターの回転方向の同調的制御における CheR, CheB の役割
The role of CheR and CheB in coordinated switching of flagellar motor in Escherichia coli
Tatsuki Hamamoto, Yong-Suk Che, Akihiko Ishijima, Hajime Fukuoka (Grad. Sch. Frontier Biosci.,
Osaka Univ.)
Quantitative analysis for the ratio of WT and mutant receptors that collapses receptor
cooperativity in chemotaxis in Escherichia coli
Shin Koguchi, Hajime Fukuoka, Akihiko Ishijima, Yong-Suk Che (Grad.Sch. Frontier Biosci., Osaka
Univ)
Probing cell-wall synthesis dynamic using bacterial membrane protein-complex
Yi-Jen Sun, Chien-Jung Lo (Department of Physics and Graduate Institute of Biophysics, National Central
University, Zhongli, Taiwan 32001)
らせん形細菌スピロヘータの推進力測定
Force measurement of the spirochete Leptospira swimming
Keigo Abe1, Kyosuke Takabe2, Shuichi Nakamura1 (1Grad.Sch.Eng., Tohoku Univ., 2Life and Env.Sci.,
Tsukuba Univ.)– S160 –2Pos315

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細胞性粘菌や好中球の基質の硬さ感知
Rigidity sensing of fast-moving cell types
Chika Okimura1, Yuichi Sakumura2,3, Katsuya Shimabukuro4, Yoshiaki Iwadate1 (1Fac. Sci., Yamaguchi
Univ., 2Sch. Inf. Sci. Tech., Aichi Pref. Univ., 3Grad. Sch. Sci. Tech., NIST, 4Nat. Ins. Tech. Ube Col.)
アクチンフィラメントに結合した MAPs の微小管重合促進活性の評価
Microtubule assembly-promoting activity of MAPs bound to actin filaments
Chihiro Doki1, Miyuki Siga1, Syoma Saitou1, Susumu Kotani2, Kiyotaka Tokuraku1 (1Grad. Sch. Sustain,
Environ. Eng., Muroran Inst. Technol., 2Fac. Sci., Kanagawa Univ.)
アクチン繊維の集団運動により形成されるベルト状パターン
The shape of belt-like patterns with millimeter size emerged from actomyosin motility
Kentaro Ozawa1, Hirotaka Taomori1, Itsuki Kunita2, Shigeru Sakurazawa3, Hajime Honda1 (1Dept.
Bioeng., Nagaoka Univ. Tech., 2Univ. Ryukyus, 3Future Univ. Hakodate)
重力下での形態形成に対する YAP 依存のアクトミオシンネットワークの寄与
Theoretical study of contribution of YAP-dependent actomyosin network to morphogenesis
under gravity
Kazunori Takamiya, Seirin Ri, Hiraku Nishimori, Akinori Awazu (Grad. Sch. Sci., Univ. Hiroshima Dept.
Math and Life Sci)
中心体アクチンネットワークによる微小管の形成制御
Regulation of microtubule growth by centrosomal actin network
Daisuke Inoue1, Dorian Obino2,3,4, Francesca Farina5, Jeremie Gaillard5, Christophe Guerin5,
Laurent Blanchoin1,5,6,7,8,9, Ana-Maria Lennon-Dumenil2,3,4, Manuel Thery1,5,6,7,8,9 (1CEA, BIG, 2PSL
Research Univ., 3INSERM, 4Institute Curie, 5CNRS, 6INRA, 7Grenoble-Alpes Univ., 8Paris 7 Univ., Univ.
Inst. Hematology, 9Saint Louis Hospital)
FilGAP PH ドメインの構造と機能の解析
Structural and functional analysis of FilGAP PH domain
Koji Tsutsumi1, Yurina Suzuki1, Shunsuke Sato2, Go Watanabe2, Yasutaka Ohta1 (1Div. of Cell Biol., Sch.
of Sci., Kitasato Univ., 2Div. of Biophysics., Sch. of Sci., Kitasato Univ.)
微小管結合蛋白質が微小管の強度と曲がりやすさに与える影響
Influence of microtubule-associated protein on strength and flexibility of microtubules
Miki Tamura1, Kazuhumi Matsui1, Kabir Arif Md. Rashedul2, Akira Kakugo2, Susumu Kotani3,
Kiyotaka Tokuraku1 (1Div. Sust. Env. Eng. Muroran Inst. Tech, 2Fac. Sci. Hokkaido Univ, 3Fac. Sci,
Kanagawa Univ.)
アメーバ運動中の ABP 局在形成機構の解明のためのアクチンと ABP からなる in vitro 系の構築
A new, actin and ABP-based in vitro system for elucidating the mechanism of intracellular ABP
localization during amoeboid movement
Yosuke Yamazaki, Taro Q.P. Uyeda (Dept. Physics, Waseda Univ.)
Examining force regulation of anaphase cellTakeshi Itabashi1,2, Shin'ichi Ishiwata2 (1RIKEN BDR, 2Fac. Sci. Eng., Waseda Univ.)
C 型インフルエンザウイルスの直進的運動
Directional motility of influenza C virus
Tatsuya Sakai1, Hiroaki Takagi2, Yasushi Muraki3, Mineki Saito1 (1Department of Microbiology,
Kawasaki Medical School, 2Department of Physics, School of Medicine, Nara Medical University,
3Department of Microbiology, School of Medicine, Iwate Medical University)
紡錘状細胞集団の示す配向秩序と牽引力
Traction Force and Dynamics in Orientation Order of Spindle-shaped Cells
Masahito Uwamichi1, Kyogo Kawaguchi2, Masaki Sano1 (1Dept. of Phys, Univ. of Tokyo, 2Dept. of System
Biol, Harvard Med. Sch.)– S161 –2Pos326

ARF1 activation initiates a regulation circuit for ARF1 and RAC1 activities in GPCR-mediatedneutrophil chemotaxis
Yuichi Mazaki1, Yasuhito Onodera2, Tsunehito Higashi1, Takahiro Horinouchi1, Tsukasa Oikawa2,
Hisataka Sabe2 (1Dept. Cell. Pharm., Grad. Sch. Med., Hokkaido Univ., 2Dept. Mol. Biol., Grad. Sch. Med.,
Hokkaido Univ.)
バイオイメージング／Bioimaging

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2Pos410Investigation of binding mechanism of E-cadherin by high-speed atomic force microscopy (HSAFM)
Hiroki Watanabe1, Sivasankar Sanjeevi2, Takayuki Uchihashi3 (1RIBM Co., Ltd., 2Dept. of Phys. andAstron., Iowa State Univ., 3Dept. of Phys., Nagoya Univ.)
ホウレンソウ由来ストロマラメラに内在する F0 c-リングの原子間力顕微鏡による観察
Observation of the c subunit ring of F0 in stroma lamellae membrane from spinach by atomic
force microscopy
Daisuke Yamamoto, Risa Mutoh (Fac. Sci. Fukuoka Univ.)
Simultaneous observation of a living COS7 cell using high-speed atomic force microscopy andfluorescence microscopy
Hiroki Furuhashi1, Mikihiro Shibata2,3 (1Grad. Sch. Math. & Phys., Kanazawa Univ., 2Infiniti, Kanazawa
Univ., 3WPI-NanoLSI, Kanazawa Univ.)
マウスノロウイルス MNV-S7 のクライオ電顕単粒子構造解析
Capsid Structure of Murine Norovirus S7 revealed by cryo-electron microscopy
Chihong Song1, Reiko Todaka2, Kei Haga2, Akira Fujimoto2, Masaru Yokoyama3, Naoyuki Miyazaki4,
Kenji Iwasaki4, Kazuhiko Katayama2, Kazuyoshi Murata1 (1National Institute for Physiological Sciences,
2Kitasato University, 3National Institute of Infectious Diseases, 4Institute for Protein Research, Osaka
University)
銀、金、銀金合金ナノ粒子を用いたマルチカラー１分子イメージング
Multi-color single-molecule imaging with silver, gold, and silver/gold-alloy nanoparticles
Jun Ando1,2, Akihiko Nakamura1,2, Mayuko Yamamoto1, Ryota Iino1,2 (1IMS, NINS, 2SOKENDAI)
細胞内自発的発熱の検出と生理的意義の解明
Investigating the detection and the significance of spontaneous intracellular thermogenesis
Cuiyuan Cai1, Kohki Okabe1,2, Takashi Funatsu1 (1Grad. Sch. Pharm. Sci., Univ. Tokyo, 2PRESTO, JST)
Fluorescence correlation spectroscopy analysis of RNA degradation in cells
Naotaka Shimada1, Kazunori Watanabe1, Takashi Ohtsuki1,2 (1Grad. Sch. Nat., Univ. okayama, 2Grad.
Sch. Int., Univ. okayama)
The fast reporter system for quantification of the transcription by using BRET and the split
luciferase complementation
Taishi Kakizuka1,2, Akira Takai2, Keiko Yoshizawa2, Yasushi Okada2, Tomonobu Watanabe1,2 (1FBS,
Univ. Osaka, 2BDR, Riken)
高次粒子数輝度解析法を用いたタンパク質オリゴマー分布解析：多成分系への応用に向けてProtein Oligomer Distribution Analysis by High Order Number and Brightness Analysis: towards
the Application to Multiple Components
Ryosuke Fukushima1, Johtaro Yamamoto2,3, Masataka Kinjo2 (1Grad. Sch. of Life Sci., Hokkaido Univ.,
2Fac. of Adv. Life Sci., Hokkaido Univ., 3Biomed. Res. Inst., AIST)
Single fluorophore imaging using a DIY microscope with high extensibility
Takashi Sagawa, Wataru Nakashima, Kazuki Nakajima, Shin Yamaguchi, Tomohiro Masuda,
Yuichi Inoue (SIGMAKOKI Co.,LTD.)– S162 –2Pos411

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2Pos421A multi-emitter fitting algorithm for potential live cell super-resolution imaging over a wide rangeof molecular densities
Tomochika Takeshima1, Teruo Takahashi1, Jiro Yamashita1, Yasushi Okada2, Shigeo Watanabe1(1Hamamatsu Photonics K.K., System division, 2RIKEN Center for Biosystems Dynamics Research)
単一細胞 ATP イメージングにより明らかになった不均一な代謝状況下での頑健なエネルギー量調節
Single-cell ATP imaging reveals robust energy level control despite unequal metabolic contexts
Hideyuki Yaginuma, Yasushi Okada (BDR, RIKEN)
Development of programmable RNA-binding protein and its application for live-cell imaging andmanipulation of authentic RNAs
Akira Takai1, Yasushi Okada1,2 (1BDR, RIKEN, 2Grad. Sch. of Sci., Univ. of Tokyo)
共焦点画像解析による新規 FCS/FCCS 法の開発とその応用
A new FCS/FCCS method based on the image processing of a confocal laser scanningmicroscope and applications for it
Kazunari Mouri1, Yasushi Okada1,2 (1BDR, RIKEN, 2Univ. Tokyo, Grad. Sch. Sci., Dept. Phys.)Single-molecule detection of combinatorial histone modifications for key genes in EpithelialMesenchymal-Transition
Jen-Chien Chang1, Ye Liu1, Kazuhide Watanabe1, Prashanti Jeyamohan1, Haruka Yabukami1, Yuko Sato2,
Hiroshi Kimura2, Akiko Minoda1 (1RIKEN IMS, 2Tokyo Tech, Dept. Life Sci. Tech.)
X 線自由電子レーザーを用いた低温 X 線回折イメージングによる異なる細胞周期にある酵母細胞
核の構造解析
Structural analyses of yeast nuclei in different cell phases by X-ray diffraction imaging at
cryogenic temperature using XFELTakahiro Yamamoto1,2, Amane Kobayashi2, Mao Oide1,2, Koji Okajima1,2, Tomotaka Oroguchi1,
Masaki Yamamoto2, Masayoshi Nakasako1,2 (1Grad. Sci. Tech. Keio Univ., 2RSC, RIKEN)
High-speed imaging of muscle myosin and super-resolution imaging of epidermal growth factor
receptor with DNA origami technique
Keisuke Fujita1,2, Michio Hiroshima1, Toshio Yanagida1,2, Mitsuhiro Iwaki1,2 (1BDR, RIKEN, 2Grad. Sch.
of Front. Bioscience., Osaka Univ.)
ゆらぎを利用した非侵襲力測定の軸索輸送動画解析への応用
Fluctuation-based non-invasive force measurement for dynamic image analysis of axonaltransport
Yasuhiro Hieda1, Takashi Sagawa2, Kyoko Chiba3,4, Kumiko Hayashi1,5 (1Dep. Appl. Phys., Grad. Sch. ofEng., Tohoku Univ., 2NICT, 3Lab. Neuroscience, Grad. Sch. Pharm. Sci., Hokkaido Univ., 4Col. Biol. Sci.,
UC DAVIS, 5PRIME, AMED)
生細胞核内における転写因子 MafG の２量体化に依存した１分子動態
Dimerization dependent single-molecule dynamics of MafG transcription factor in living cellYuma Ito1, Takahiro Maeda1, Kumiko Sakata-Sogawa3, Masaaki Shiina2, Makio Tokunaga1 (1Sch. Life Sci.
Tech., Tokyo Inst. Tech., 2Grad. Sch. Med. Life Sci., Yokohama City Univ., 3Grad. Sch. Agr. Sci., Tohoku
Univ.)
遺伝子コード型抗体プローブを用いた翻訳後修飾の１分子イメージング
Single-molecule imaging of post-translational modification using genetically encoded antibody
probe
Shuntaro Sato1, Yuma Ito1, Yuko Sato2, Hiroshi Kimura2, Makio Tokunaga1 (1Sch. Life Sci. Tech., Tokyo
Inst. Tech., 2IIR, Tokyo Inst. Tech.)
ヘテロクロマチンタンパク HP1α 動態の生細胞 1 分子イメージング
Dynamics of Heterochromatin protein 1α in living cells using single-molecule imaging
Takahiro Maeda1, Yuma Ito1, Shin-Ya Isobe2, Chikashi Obuse2, Makio Tokunaga1 (1Sch. Life Sci. Tech.,Tokyo Inst. Tech., 2Biosci. Grad Sch Sci., Osaka Univ)– S163 –2Pos422

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悪性高熱症関連変異を有する骨格筋型リアノジン受容体の構造と機能変化
Structure and function change of skeletal muscle-type ryanodine receptor
Toshiko Yamazawa1, Maki Yamaguchi1, Haruo Ogawa2, Takashi Murayama3, Hideto Oyamada4,
Nagomi Kurebayashi3, Junji Suzuki5, Kazunori Kanemaru5,6, Takashi Sakurai3, Masamitsu Iino5,6 (1Dept
Mol. Physiol., Jikei Univ. Sch. Med., 2Institute Quantitative Biosci., The Univ.Tokyo, 3Dept. Pharmacol.,Juntendo Univ. Sch. Med., 4Dept. Pharmacol., Sch. Med., Showa Univ., 5Dept. Pharmacol., Grad. Sch.
Med., The Univ.Tokyo, 6Dept. Cell. Mol. Pharmacol., Nihon Univ. Sch. Med.)
ゼロモード導波路(ZMW)を用いた生体分子複合体の定量分析
Quantitative analysis of biomolecular complexes using Zero-Mode Waveguides (ZMW)
Kimiko Nakao1, Hisashi Tadakuma1, Yong-Woon Han2, Yoshie Harada1 (1IPR, Osaka Univ., 2IMS.,RIKEN)
線形ゼロモード導波路を用いたアクチン重合の 1 分子解析
Single-molecule analysis of actin polymerization using linear zero-mode waveguides
Soichiro Fujii1, Ryo Iizuka1, Masamichi Yamamoto1, Makoto Tsunoda1, Takashi Tanii2, Takashi Funatsu1(1Grad. Sch. Pharm. Sci., Univ. Tokyo, 2Fac. Sci. Eng., Waseda Univ.)

3 日目（9 月 17 日（月））／Day 3（Sep. 17 Mon.）
PA 会場（大集会室），PB 会場（南第二集会室），PC 会場（南第三集会室），PD 会場（南第四集会室） ／Room PA (Large Assembly Room), Room PB (2nd South Assembly Room),
Room PC (3rd South Assembly Room), Room PD (4th South Assembly Room)
ヘム蛋白質／Heme proteins
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ヒト成人ヘモグロビンの四量体構造の安定性に対する β サブユニットの Fe-His 結合の寄与
Contribution of the Fe-His Bond of the β Subunit to Stability of Tetramer of α2β2 in Human Adult
Hemoglobin
Shigenori Nagatomo1, Masako Nagai2, Teizo Kitagawa3 (1Dept. Chem., Univ. Tsukuba, 2Res. Center
Micro-Nano Tech., Hosei Univ., 3Grad. Sch. Life Sci., Univ. Hyogo)
ヘムタンパク質におけるヘム周囲のタンパク質環境の網羅解析
Global analysis of the protein environment around heme in hemeproteins
Hiroko X. Kondo1, Masanori Fujii1, Yusuke Kanematsu2, Yasuhiro Imada3, Yu Takano2 (1Fac. Eng.,
Kitami Inst. Tech., 2Grad. Sch. Info. Sci., Hiroshima City Univ., 3IPR, Osaka Univ.)
鉄還元酵素ヒト Steap3 の分子機能解明
Analyses on the molecular function of human Steap3 as a ferric reductase
Akito Nakata1, Mika Fujimura1, Fusako Takeuchi2, Motonari Tsubaki1 (1Dept. of Chem., Grad. Sch. Sci.,
Kobe Univ., 2IPHE, Kobe Univ.)
呼吸鎖 A タイプ酸素還元酵素のカルシウムイオン結合構造
Calcium ion-binding structure of respiratory A-type oxygen reductase
Kazumasa Muramoto, Kyoko Shinzawa-Itoh (Grad. Sch. Life Sci., Univ. Hyogo)
金属タンパク質の酸化還元電位の第一原理計算
Ab initio evaluation of redox potential of metalloprotein
Cheng Cheng, Shigehiko Hayashi (Kyoto Univ)– S164 –膜蛋白質／Membrane proteins
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レーザーフラッシュフォトリシスによるリン脂質二分子膜へ再構成した proteorhodopsin の光サイクルに関する研究
A study on photocycle of proteorhodopsin reconstituted in phospholipid bilayer by laser flash
photolysis
Airi Yamamoto1, Fumio Hayashi2, Toshinori Motegi1, Takashi Kikukawa3,4, Masashi Sonoyama1 (1Grad.
Sch. Sci. Tech., Gunma Univ., 2Ctr. Inst. Anl., Gunma Univ., 3Fac. Adv. Life Sci., Hokkaido Univ., 4GICoRE, Hokkaido Univ.)
カロテノイド末端基のアシル化が及ぼすハロロドプシン-バクテリオルベリン複合体形成への影響
Effect of acylation of carotenoid terminal group on halorhodopsin-bacterioruberin complex
formation
Fumiya Hattori, Takanori Sasaki (Grad.Sch.Adv.Math.Sci.,Meiji Univ)
古細菌膜上におけるハロロドプシンのレチナール再結合能力
Retinal rebinding ability of halorhodopsin on archaeal membrane
Shun Yano, Takanori Sasaki (Graduate School of Advanced Mathematical Sciences, Meiji University)
古細菌 N.Pharaonis 由来の膜タンパク質ハロロドプシンの複素環式化合物存在下における安定化
Thermal stability of halorhodopsin from N.Pharaonis in the presence of heterocyclic compound
Shinichiro Hayashi, Takanori Sasaki (Grad. Sch. Adv. Math. Sci., Meiji Univ.)
RxR の極めて高い熱安定性に対する統計熱力学
Statistical thermodynamics for the extremely high thermostability of a microbial rhodopsin fromthe eubacterium Rubrobacter (RxR)
Tomohiko Hayashi1, Satoshi Yasuda1,2,3, Kano Suzuki2, Tomoki Akiyama2, Kanae Kanehara4,
Yuki Sudo4, Takeshi Murata2,3,5, Masahiro Kinoshita1 (1Inst. Adv. Energy, Kyoto Univ., 2Grad. Sch. Sci.,
Chiba Univ., 3MCRC, Chiba Univ., 4Fal. Pharm. Sci., Okayama Univ., 5PREST, JST)
サーモフィリックロドプシンの非常に高い熱安定性の物理起源
Physical origin of exceptionally high thermostability of thermophilic rhodopsin
Satoshi Yasuda1,2,3, Tomohiko Hayashi3, Yuta Kajiwara4, Takeshi Murata1,2,5, Masahiro Kinoshita3(1Chiba Univ., Grad. Sch. Sci., 2Chiba Univ., MCRC, 3Kyoto Univ., IAE, 4Kyoto Univ., Grad. Sch. Ene. Sci.,
5PRESTO)
アルカリ条件下におけるバクテリオルベリンと古細菌脂質の結合に伴うハロロドプシンの熱安定化
Thermal stabilization of halorhodopsin by binding of bacterioruberin and archaeal lipids underalkaline condition
Kenichi Takeda1, Takashi Kikukawa2, Makoto Demura2, Takanori Sasaki1 (1Grad. Sch. Adv. Math. Sci.,
Meiji Univ., 2Fac. Adv. Life Sci., Hokkaido Univ.)
脂質二重膜中の AMPA 受容体の高速 AFM 観察
High-speed atomic force microscopy imaging of AMPA receptors in lipids
Kento Ikeda1, Wenlong Gao2, Yao Wang2, Motoyuki Hattori2, Mikihiro Shibata3,4 (1Grad. Sch. Math. &Phys., Kanazawa Univ., 2Sch. Life Sci., Fudan Univ., 3InFiniti, Kanazawa Univ., 4WPI-NanoLSI, Kanazawa
Univ.)
High-speed AFM imaging of membrane protein embedded in Nanodisc
Takamitsu Haruyama1, Yasunori Sugano1, Noriyuki Kodera2, Takayuki Uchihashi3, Toshio Ando2,
Yoshiki Tanaka1, Hiroki Konno2, Tomoya Tsukazaki1 (1Nara Inst. of Sci. and Tech., 2WPI-NanoLSI,
Kanazawa Univ., 3Dept. of Physics, Nagoya Univ.)
構造生物学的解析に向けた TRPV3 のナノディスク化について
Reconstitution of TRPV3 into Nanodiscs for structural study
Tomoki Maeda1, Kaname Ojima1, Shingo Nagano2, Tomoya Hino2 (1Grad. Sch. Sus. Sci., Tottori Univ.,
2Grad. Sch. Eng., Tottori Univ.)– S165 –3Pos016

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3Pos026X 線 1 分子追跡法による TRPV1 チャネルの 3 次元運動
3D motion of TRPV1 cation channel depicted by diffracted X-ray tracking method
Shoko Fujimura1, Kazuhiro Mio1, Masahiro Kuramochi2, Hiroshi Sekiguchi3, Muneyo Mio1, Tai Kubo1,
Yuji C. Sasaki1,2,3 (1OPERANDO-OIL, AIST, 2Grad. Sch. Frontier Sci., Univ. Tokyo, 3JASRI/Spring-8)分子シミュレーションによるヘムインポーターの化学-力学共役機構の解明
Deciphering chemomechanical coupling mechanism of a heme importer with molecularsimulations
Koichi Tamura1, Hiroshi Sugimoto2,3, Yoshitsugu Shiro2, Yuji Sugita1,4,5 (1RIKEN R-CCS, 2Grad. Sch.
Life Sci., Univ. Hyogo, 3RIKEN SPring-8, 4RIKEN TMS, 5RIKEN BDR)
Nanodisc を用いたリン脂質二重膜環境中におけるヒトセロトニン受容体の機能解析
Functional analyses of human serotonin receptor in phospholipid membrane environments
using Nanodisc
Kouhei Yoshida1, Daisuke Kuroda1,2,3, Satoru Nagatosihi1,3,4, Kouhei Tsumoto1,3,4 (1Dept. of Bioeng., Sch.
of Eng,. Univ. of Tokyo, 2RS Med. Dev. Dev. Reg. Res. Center, Sch. of Eng., Univ. of Tokyo, 3Dept. of
Chem. Biotech., Sch. of Eng., Univ. of Tokyo, 4Inst. of Med. Sci., Univ. of Tokyo)
ATR-FTIR を用いた細菌べん毛固定子のイオン透過経路の解析
Analysis of Na+-conducting pathway in the stator complex of the bacterial flagellar motor by
ATR-FTIR spectroscopy
Hiroyuki Terashima1, Masayo Iwaki2, Hideki Kandori2, Michio Homma1 (1Div. Biol. Sci., Grad. Sch. Sci.,
Nagoya Univ., 2Dept. Life Sci. Appl. Chem., Nagoya Inst. Tech.)
マグネシウムイオンチャネル MgtE のイオン―タンパク質間相互作用の振動解析
Vibrational analysis for studying ion-protein interactions of a magnesium ion channel, MgtE
Tetsunari Kimura1,2,7, Victor Lorenz-Fonfria3,4, Shintaro Doki5, Hideyoshi Motoki6, Ryuichiro Ishitani5,
Osamu Nureki5, Masahiro Higashi6, Yuji Furutani1,2 (1Inst. Mol. Sci., 2SOKENDAI, 3ICMol, Univ.
Valencia, 4Dep. Biochem. Mol. Biol., Univ. Valencia, 5Grad. Sch. Sci., Univ. Tokyo, 6Grad. Sch. Eng. Sci.,
Univ. Ryukyus, 7Grad. Sch. Sci., Kobe Univ.)
A Multiscale Model for Flavivirus Dynamics & Host Interactions
Jan K. Marzinek, Roland G. Huber, Daniel A. Holdbrook, Peter J. Bond (Bioinformatics Institute(A*STAR), #07-01, Matrix, 138671 Singapore)Direct reconstitution of membrane proteins from cell membrane blebs into a model biologicalmembrane
Rurika Nagai1, Yasushi Tanimoto2, Rinshi Kasai3, Kenichi Suzuki4,7, Fumio Hayashi5, Kenichi Morigaki6(1Grad. Sch. Agr., Univ. Kobe, 2Biosignal research Center., Univ. Kobe, 3Institute for Frontier Life andMedical Sciences., Univ. Kyoto, 4G-chain., Univ. Gifu, 5Grad. Sch. Scie., Univ. Kobe, 6Grad. Sch. Agr.,
Univ. Kobe, 7Grad of Nat. Scie and Tech., Univ. Gifu)
1 分子イメージングによる PDGF 受容体-Akt シグナル伝達の研究
Single molecule imaging study on PDGF receptor and Akt signal transduction
Hideaki Yoshimura, Takeaki Ozawa (Department of Chemistry, School of Science, The University ofTokyo)
Solubilization and purification of the Rieske/cytochrome b complex in green sulfur bacteria
Hiraku Kishimoto1, Chihiro Azai2, Risa Mutoh3, Hideaki Tanaka4, Genji Kurisu4, Hirozo Oh-oka1 (1Grad.
Sch. Sci., Osaka Univ., 2Grad. Sch. Lif. Sci., Ritsumeikan Univ., 3Fac. Sci., Fukuoka Univ., 4Inst. ProteinRes., Osaka Univ.)
線虫 Cytochromeb561 ホモログ Cecytb-2 のアスコルビン酸特異的電子伝達反応解析
Analyses on the ascorbate-specific electron transfer function of Cecytb-2, a cytochrome b561
homolog in Caenorhabditis elegans
Misaki Fukuzawa, Mika Fujimura, Masahiro Miura, Tetsunari Kimura, Motonari Tsubaki (Dept. of Chem.,
Grad. Sch. Sci., Kobe Univ.)
三量体オートトランスポーターの構造形成における荷電残基の役割
Roles of charged residues on assembly of the trimeric autotransporter transmembrane domain
Eriko Aoki, Daisuke Sato, Kazuo Fujiwara, Masamichi Ikeguchi (Fac. of Sci. and Eng., Soka Univ.)– S166 –3Pos027

Ubiquitination of MHCII changes tendency of antigen presentation due to structral conversion of
MHCII
Takashi Kawamoto1, Yuko Kozono1, Jae-won Chang2, Masahiro Kuramochi2, Yuji Sasaki2,
Haruo Kozono1 (1Grad. Sch. bio, TUS, 2Grad. Sch. fro, Univ. Tokyo)
光生物／Photobiology: Photosynthesis

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Light-induced FTIR spectroscopic studies on quinone exchange mechanism of the LH1-RC
complexes from native and chimeric purple bacteria
Rikako Kishi1, Michie Imanishi1, Kanako Hashimoto1, Kenji Nagashima2, Masayuki Kobayashi3,
Shinji Takenaka1, Zheng-yu Wang-Otomo4, Yukihiro Kimura1 (1Grad. Agri., Univ. Kobe, 2Photobio Inst.,
Univ. Kanagawa, 3Ariake Kosen, 4Sci., Univ. Ibaraki)
光化学系 II の水の酸化反応における D1/V185 の役割
The role of D1/V185 in the water oxidation mechanism in Photosystem II
Itsuki Takachi1, Yuya Hara1, Alain Boussac2, Miwa Sugiura3 (1Grad. Sch. Sci and Eng, Ehime Univ, 2CEA
Saclay, 3PROS, Ehime Univ)
Thermodynamic Dissociation Kinetics assay to determine the binding strengths within amembrane protein complex
Eunchul Kim, Ryutaro Tokutsu, Akimasa Watanabe, Jun Minagawa (National Institute for Basic Biology)
Biosynthesis of Gold Nanoparticles by photosynthetic apparatus
Hiroki Matsumura1, Rie Nagayoshi1, Mariko Miyachi2, Daiki Nishiori2, Yoshinori Yamanoi2,
Hiroshi Nishihara2, Tatsuya Tomo1 (1Faculty of Science, Tokyo University of Science, 2School of Science,
The University of Tokyo)
クロロフィル d を主要色素とするシアノバクテリア光化学系 II における分光特性
Absorption and fluorescence properties of Photosystem II complex in a chlorophyll d-dominatedcyanobacterium
Reona Toyofuku1, Seiji Akimoto2, Toshiyuki Shinoda1, Tatsuya Tomo1 (1Grad. Sch. Sci., Tokyo Univ.
Sci., 2Grad. Sch. Sci., Univ. Kobe.)
The orientation of menaquinone in the heliobacterial reaction center analyzed with the EPR
spectroscopy
Toru Kondo1, Chihiro Azai2, Shigeru Itoh3, Hirozo Oh-oka4 (1Dept. Chem., MIT, 2Coll. Life Sci.,
Ritsumeikan Univ., 3Grad. Sch. Sci., Nagoya Univ., 4Grad. Sch. Sci., Osaka Univ.)
Role of D1-Ser169 near O4 of the Mn4CaO5 cluster in photosynthetic water oxidation
Yuichio Shimada1, Tomomi Kitajima-Ihara1, Ryo Nagao1,2, Takumi Noguchi1 (1Grad. Sch. Sci., Nagoya
Univ., 2RIIS, Okayama Univ.)
光合成水分解反応の S2→S3 遷移におけるプロトン共役電子移動の時間分解赤外分光解析
Mechanism of proton-coupled electron transfer in the S2-S3 transition of photosynthetic wateroxidation revealed by TRIR analysis
Hiroshi Takemoto, Takumi Noguchi (Grad. Sch. Sci., Nagoya Univ.)
Effect of replacement of Cl- with NO3- on photosynthetic water oxidation as studied by timeresolved infrared spectroscopy
Yasutada Okamoto, Takumi Noguchi (Grad. Sch. Sci., Nagoya Univ.)
FTIR-spectroelectrochemical study on the pH dependence of the redox potential of the nonheme iron in photosystem II
Hiroki Watanabe, Takumi Noguchi, Yuki Kato (Grad. Sch. Sci., Nagoya Univ.)
QM/MM analysis of the DOD vibrations of water molecules around the Mn4CaO5 cluster inphotosystem II
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光合成における電子伝達体拡散のルーメン環境依存性に関する理論的研究
Theoretical studies on dependence of diffusion of electron carriers in photosynthesis onenvironment in lumen side
Hidemi Nagao, Isman Kurniawan, Arwansyah Saleh, Koichi Kodama, Satoshi Nakagawa,Kazutomo Kawaguchi (Kanazawa University)
LOV を導入したファシンによるアクチン束化の制御
Regulation of actin bundles by using LOV-fused fascin
Ikuko Fujiwara1, Miki Iwatani1, Yumeka Yamauchi2, Tatsuya Iwata3, Shuichi Takeda4, Toshiro Oda5,
Tomoharu Matsumoto4, Akihiro Narita4, Satoshi Tsunoda2,6, Hideki Kandori2 (1NITech, 2Grad Sch Eng,
Nagoya Inst Tech, 3Toho University, 4Grad. Sch. Sci., Univ. Nagoya, 5Univ. Tokaigakuin, 6JST)
Aureo １における C 末端 Jα ヘリックスの役割
The role of the C-terminal Jα helix in Aureochrome-1
Hiroto Nakjima, Osamu Hisatomi, Itsuki Kobayashi (grad.sch.sci.,Univ.Osaka)Calcium concentration modulation in HeLa cells induced by mid-infrared laser irradiation
Yoshiyuki Shimizu, Toyohiko Yamauchi, Tatsuo Dougakiuchi, Gen Takebe (Hamamatsu Photonics K.K.)
光駆動プロトンポンプ型ロドプシンのシロイヌナズナへの異種発現の試み
An attempt of heterologous expression of light-driven proton pump rhodopsins in the higher
plant Arabidopsis thaliana
Saki Inoue1, Yurie Nagase2, Kyohei Harada3, Keiichi Kojima1,2, Shintaro Munemasa4,
Susumu Yoshizawa5, Yoshiyuki Murata4, Shinji Masuda6, Yuki Sudo1,2 (1Grad. Sch. of Med. Dent. &Pharm. Sci., Okayama Univ., 2Fac. of Pharm. Sci., Okayama Univ., 3Grad. Sch. Biosci. Biotechnol., Tokyo
Inst. Technol., 4Grad. Sch. Environ. Life Sci., Okayama Univ., 5AORI, UTokyo, 6Cent. Biolog. Resources &Informatics, Tokyo Inst. Technol.)
緑藻クラミドモナスの葉緑体へのプロトンポンプ型ロドプシンの異所発現と葉緑体プロトン濃度
勾配制御の試み
Expression of proton pump rhodopsins in the chloroplast of the alga Chlamydomonas reinhardtii
for optical control of proton gradientYurie Nagase1, Saki Inoue2, Hiroshi Kuroda3, Keiichi Kojima1,2, Susumu Yoshizawa4,
Yuichiro Takahashi3, Yuki Sudo1,2 (1Fac. of Pharm. Sci. Okayama Univ., 2Grad. Sch. of Med. Dent. Pharm.
Sci. Okayama Univ., 3RIIS. Okayama Univ., 4AORI, UTokyo.)
Development of Red-Shifted Channelrhodopsin Variants Using Long-Conjugated Retinal
Analogues
Yi-Chung Shen1, Toshikazu Sasaki1, Takesi Matsuyama Hoyos1, Takahiro Yamashita1,
Yoshinori Shichida1,2, Takashi Okitsu3, Yumiko Yamano3, Akimori Wada3, Toru Ishizuka4,
Hiromu Yawo4, Yasushi Imamoto1 (1Dept. of Biophys., Grad. Sch. of Sci., Kyoto Univ., 2Res. Org. for Sci.
& Tech., Ritsumeikan Univ., 3Lab. of Organ. Chem. for Life Sci., Kobe Pharm. Univ., 4Dept. of Dev. Bio. &Neurosci., Grad. Sch. of Life Sci., Tohoku Univ.)
Theoretical study on molecular mechanism of a light-driven ion transport of Halorhodopsin
Ryo Oyama, Taisuke Hasegawa, Shigehiko Hayashi (Grad. Sch. Sci., Univ. Kyoto)
化学受容／Chemoreception

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シグナル伝達分子の細胞膜上空間分布解析
Spatial distribution analysis of signaling proteins on the cell membrane
Hiroaki Takagi1, Yukihiro Miyanaga2, Satomi Matsuoka3, Masahiro Ueda2,3 (1Sch. Med., Nara Med.
Univ., 2Grad. Sch. Front. Bio. Sci., Osaka Univ., 3BDR, Riken)
大腸菌走化性応答における CheY 極局在の役割
Role of polar localization of chemotaxis protein CheY for the intracellular signaling under nonstimulated conditions in Escherichia coli
Yong-Suk Che, Akihiko Ishijima, Hajime Fukuoka (Dept. Frontier Biosci., Osaka Univ)– S168 –3Pos049

コレラ菌タウリン走性受容体 Mlp37 の温度依存的遺伝子発現
Temperature-dependent gene expression of the taurine sensor Mlp37 of Vibrio cholerae
So-ichiro Nishiyama3, Shiori Onogi1, Yoshiyuki Sowa1,2, Hiroshi Urakami3, Ikuro Kawagishi1,2 (1Dept.
Frontier Biosci., Hosei Univ., 2Res. Cen. Micro-Nano Tech., Hosei Univ., 3Fac. App. Life Sci., Niigata
Univ. Pharm. App. Life Sci.)
結晶成長・結晶化技術／Crystal growth & Crystallization technique3Pos050

ファインバブル水を利用したタンパク質結晶化の新しいアプローチ
Novel approach for protein crystallization with ultrafine bubble water
Taichi Naruse1, Mihoka Amano1, Hiroaki Adachi2, Shigeo Maeda3, Toshihiro Fujita3, Yusuke Mori4,
Shigeru Sugiyama5 (1Grad. Sch. Sci., Kochi Univ., 2SOSHO Inc., 3IDEC Corp., 4Grad. Sch. Eng., Osaka
Univ., 5Fac. Sci. & Tec., Kochi Univ.)
蛋白質：機能／Protein: Function

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国産無償創薬ソフトウェア myPresto の進展：ΔG 推算を中心に
Progress of free drug development software suite myPresto: focusing on ΔG estimation
Tadaaki Mashimo1,2, Yoshifumi Fukunishi3 (1N2PC, 2IMSBIO Co., Ltd., 3AIST(molprof))
The binding mechanism of Hepatitis B virus X protein to Smc5/6 complex
Katsumi Omagari, Yasuhito Tanaka (Nagoya City Univ.)
タンパク質−タンパク質結合の粗視化 MD シミュレーション: barnase と barstar を例としてCoarse grained molecular dynamics simulation of barnase-barstar binding
Yu Sugimoto1,3, Yoshitaka Moriwaki1, Tohru Terada1,2, Kentaro Shimizu1 (1Grad. Sch. Agri. Life Sci.,
Univ. Tokyo, 2III, Univ. Tokyo, 3JSPS)
アルケミカル自由エネルギー計算における遅い緩和
Slow relaxation on alchemical free energy calculations
Yoshiaki Tanida, Azuma Matsuura (Fujitsu Laboratories Ltd.)
Rationalization of sampling space for searching fragment-binding poses
Hiroyuki Sato, Yoshiaki Tanida, Azuma Matsuura (Fujitsu Lab. Ltd.)QM/MM metadynamics シミュレーションによる trehalose-6-phosphate phosphatase の触媒機構に関する研究QM/MM metadynamics study of the catalytic mechanism of trehalose-6-phosphate phosphataseToshihiro Hayashi, Tadaomi Furuta, Minoru Sakurai (Tokyo Tech)
QM/MM metadynamics 計算による Chitinase A の加水分解機構の解析
Theoretical analysis of the hydrolysis mechanism in Chitinase A using QM/MM metadynamics
simulation
Tsubasa Iino, Tadaomi Furuta, Minoru Sakurai (Center for Biol. Res. & Inform., Tokyo Tech)
Spectroscopic analysis of an electron-bifurcating [FeFe] hydrogenase
Krzysztof Pawlak1, Nipa Chongdar1, Olaf Rudiger1, Edward Reijerse1, Wolfgang Lubitz1, James Birrell1,
Hideaki Ogata1,2 (1MPI CEC, 2ILTS Hokkaido Univ.)
鉄硫黄クラスターを利用した tRNA 硫黄修飾酵素 TtuA の反応機構の解明
Elucidation of the tRNA thiolation mechanism of TtuA involved in Fe-S cluster
Masato Ishizaka1, Minghao Chen1, Syun Narai1, Masaki Horitani2, Seiko Oka3, Yoshikazu Tanaka4,
Min Yao1,5 (1Grad. Sch. Life Sci., Univ. Hokkaido, 2Fac. Agric., Univ. Saga, 3G.F.C., Univ. Hokkaido,
4Grad. Sch. Life Sci., Univ. Tohoku, 5Grad. Sch. Adv. Life Sci., Univ. Hokkaido)
無機ポリリン酸存在下でのアクチンとミオシン間の相互作用
Interactions between actin and myosin in the presence of inorganic polyphosphates
Koji Ito, Yoshiya Miyasaka, Kuniyuki Hatori (Grad. Sch. Sci. Eng., Yamagata Univ.)– S169 –3Pos061

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テトラヒメナ外腕ダイニンにおける致死性 P ループ変異の機能解析
Functional characterization of lethal P-loop mutations in Tetrahymena outer arm dynein (Dyh3p)
Masaki Edamatsu (Department of Life Sciences, The University of Tokyo)
ヒトジヒドロリポアミドデヒドロゲナーゼの酵素反応の制御機構における定常状態と時間分割蛍光についての研究
Steady-state and Time-resolved Fluorescence Studies on the Enzymatic Reaction Mechanismof Human Dihydrolipoamide Dehydrogenase
Yayoi Hara1, Etsuko Nishimoto2 (1Grad. Sch. Bioresour. Bioenviron. Sci., Kyushu Univ., 2Fac. Agr.,
Kyushu Univ.)
Optimizing the protocol for accelerating the analysis of the ATPase activity of circadian clock
protein KaiC
Dongyan Ouyang1, Atsushi Mukaiyama1,2, Yoshihiko Furuike1,2, Shuji Akiyama1,2 (1IMS, 2SOKENDAI)
多分子のキネシンによる協調運動の高速一分子観察
High-speed nanometer-precision tracking of the cargo transport by multiple kinesin-1 motor
proteins
Tsukasa Enomoto (Grad. Life science., Univ. Aoyama)
蛋白質：計測・解析／Protein: Measurement & Analysis

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質量分析によるヌクレオソームにおけるヒストンアセチル化の解析
Characterization of histone acetylation in nucleosome core particle using mass spectrometry
Haruna Hidaka1, Shunsuke Izumi1, Satoko Akashi2, Kazumi Saikusa1,2 (1Hiroshima university,
2Yokohama city university)
異なる pH で形成したインスリン B 鎖アミロイド核形成中間体の構造比較
Structural comparison of amyloid nucleation intermediates of insulin B chain formed at different
pH values
Yuhki Yoshikawa, Naoki Yamamoto, Atsuo Tamura, Eri Chatani (Grad.Sch.Sci.,Kobe Univ.)
固体 NMR 常磁性緩和促進法による大腸菌細胞内生体分子の局在化解析
Localization of biomolecules in E. coli cells as studied by solid-state NMR under paramagnetic
relaxation enhancement
Zhongliang Zhang, Hajime Tamaki, Kazuya Yamada, Toshimichi Fujiwara (Institute for Protein
Research, Osaka Univ.)
High-speed single molecule tracking of allosteric transitions in hemoglobin using Diffracted Xray Tracking (DXT)Yuu Okamura1, Masahiro Kuramochi1,2, Toshiki Hiraki3, Naoki Yamamoto3, Naoya Shibayama3,
Hiroshi Sekiguchi4, Yuji Sasaki1,2,4 (1The Univ. of Tokyo Grad Sch FS, 2AIST-UTokyo OPELAND-OIL,
3Jichi Med Univ, 4SPring8/JASRI)
Protein Motion Analyzed by Diffracted X-ray Blinking
Hiroshi Sekiguchi1, Masahiro Kuramochi2, Noboru Ohta1, Yuji Sasaki1,2 (1JASRI/SPring-8, 2Frontier Sci.,
Univ. Tokyo)
Nanopore probe with protein: Electrical observation of small protein motility in the nanospace
Misa Yamaji, Masaki Matsushita, Ryuji Kawano (Department of Biotechnology and Life Science, Tokyo
University of Agriculture and Technology)
インスリンアミロイドに結合したチオフラビン T の蛍光寿命特性に対する pH の影響
Effect of pH on fluorescence lifetime behavior of Thioflavin T binding to insulin amyloid
Akinori Oda, Hiroshi Satozono, Tomoo Inubushi (Hamamatsu Photonics K.K.)
高速 AFM 画像データに対する生体分子立体構造のフレキシブルフィッティング
Flexible fitting of biomolecular structures to high-speed AFM image data
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高転移性マウス乳癌細胞の細胞弾性におけるネスチンテールドメインの機能解析
Functional analysis of nestin tail domain in elastic modulus of highly metastatic mouse breast
cancer cells
Moe Susaki1, Mei Mizusawa1, Ayana Yamagishi2, Chikashi Nakamura1,2 (1Grad. Sch. Eng., Tokyo Univ.
Agric. Technol., 2Biomed. Res. Inst., AIST)タンパク質の水和／溶媒和層の定量的な評価
Quantitatively characterization of the hydration and/or solvation shell of protein
M. Hirai1, S. Ajito1, H. Iwase2, S. Arai3 (1Grad. Sch. Sci. Tech., Gunma Univ., 2Comp. Res. Org. Sci. Soc.,
3Nat. Inst. Quan. Rad. Sci. Tech.)
物理系と温度系の合成：カップルされた能勢ーフーバー方程式
A coupling of physical system and a temperature system: Coupled Nose-Hoover equations
Ikuo Fukuda1, Kei Moritsugu2 (1Grad. Sch. Sim., Univ. Hyogo, 2Grad. Sch. of Med. Life Sci., Yokohama
City Univ.)
周期境界条件下の分子動力学シミュレーションを使った結合自由エネルギー計算で生じる有限サ
イズ効果を抑えるアルケミカル摂動法の開発
An effective alchemical perturbation method eliminating finite-size effect on binding freeenergies
Toru Ekimoto, Tsutomu Yamane, Mitsunori Ikeguchi (Yokohama City Univ.)
蛋白質工学／Protein: Engineering

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アレルギー性喘息を引き起こすインターロイキン 33 の阻害タンパク質の開発
Development of a protein that inhibits interleukin-33 responsible for allergic asthma
Mio Sano1, Yoshiki Oka1, Yuuki Hayashi1, Munehito Arai1,2 (1Dept. Life Sci., Univ. Tokyo, 2Dept. Phys.,Univ. Tokyo)
細胞内ヌクレオチド定量センサーの合理的設計
Rational design of nucleotide sensors for intracellular quantitative imaging
Yoshiki Oka1, Shunji Suetaka1, Hinako Ago2, Yuna Miyachi2, Yuuki Hayashi1,2, Munehito Arai1,2,3 (1Dept.
Life Sci., Univ. Tokyo, 2College Arts Sci., Univ. Tokyo, 3Dept. Phys., Univ. Tokyo)
抗体の親和性向上におけるフレームワーク領域へのアルギニンクラスター導入の効果
Role of Arg cluster (R5) introduced into framework region (FR3) in affinity improvement
Shingo Maeta1, Makoto Nakakido1,2,3, Kouhei Tsumoto1,2,3 (1Dept. of Bioeng., Univ. of Tokyo, 2Dept. ofChem and Biotech., Univ. of Tokyo, 3Med Proteom., Inst. of Med Sci., Univ. of Tokyo)
Characterization of the “scrap-and-build” process in the proteasome α ring formation
Taichiro Sekiguchi1,2,4, Tadashi Satoh3, Kentaro Ishii1,4, Hirokazu Yagi3, Koichi Kato1,2,3,4 (1ExCELLS,
2SOKENDAI, 3Nagoya City Univ, 4Inst. for Mol. Sci.)
状態選択的に安定化された G タンパク質共役受容体の合理デザイン
Rational Design of G-Protein Coupled Receptors Stabilized in Aimed State
Masaya Mitsumoto1,2, Ryosuke Nakano3, Takeshi Murata3,4, Nobuyasu Koga1,2 (1ExCELLS, NINS,
2SOKENDAI, 3Fac. of Sci., Chiba Univ., 4PRESTO, JST)ファージディスプレイ法への応用を目指した蛍光検出ファージソーターの改良
Improvement of the fluorescent detected phage sorter for the application to phage display
Hitomi Urabe1,2, Saya Nakano1,3, Yuki Shimizu1,2, Naoki Mikosiba1,3, Hiroyuki Oikawa1,2,3,
Satoshi Takahashi1,2,3 (1IMRAM, Tohoku Univ., 2Grad. Sch. Sci., Tohoku Univ., 3Grad. Sch. Life Sci.,
Tohoku Univ.)
Design of multi-domain protein structures for small molecule binding
Hiroko Yamada1, Nobuyasu Koga2 (1SOKENDAI, 2NINS ExCELLS)
Designing an artificial transcription factor with a small molecular weight based on engrailed
homeodomain
Tomoko Sunami, Yu Hirano, Taro Tamada, Hidetoshi Kono (QST)– S171 –3Pos085

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立体構造に基づく配列プロファイルを利用した熱安定化 β-グルコシダーゼの設計に向けて
Toward design of thermostable β-glucosidase with structure-based sequence profile
Naoya Kobayashi1, Shintaro Minami1, Taku Uchiyama2, Naoki Sunagawa2, Kiyohiko Igarashi2,
Hiroyuki Noji3,4, Nobuyasu Koga1 (1ExCELLS, NINS, 2Dept. Biomater. Sci., Grad. Sch. Agri. Life Sci.,
Univ. Tokyo, 3Dept. Appl. Chem., Grad. Sch. Eng., Univ. Tokyo, 4ImPACT, JST)
平行ベータシート蛋白質の設計図におけるデザイナビリティの評価基準
Criteria for evaluating designability of pure parallel beta sheet structures
Hayao Imakawa1, Nobuyasu Koga2, George Chikenji1 (1Dept. of App. Phys., Nagoya Univ., 2CIMoS, IMS)
タンパク質-タンパク質結合部位の予測とエピトープマッピング
Prediction of Protein-Protein Binding Sites and Epitope Mapping
John Gunn2, Elizabeth Sourial2, Kinya Toda1, Paul Labute2 (1MOLSIS Inc., 2Chemical Computing Group
ULC)
理論的変異解析によるジヒドロ葉酸還元酵素の高活性化
Enhancing activity of dihydrofolate reductase by theoretical mutational analysis
Kazuhisa Ohara1, Yoshiki Oka1, Yuuki Hayashi1, Munehito Arai1,2 (1Dept. Life Sci., Univ. Tokyo, 2Dept.
Phys., Univ. Tokyo)
非平衡・発生リズム／Nonequilibrium state & Biological rhythm

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Mathematical Modeling for Morphallactic Segment Formation Using a Size-Dependent MultiLoop Negative Feedback System
Yusuke Shibasaki1, Chikako Yoshida-Noro2, Minoru Saito1 (1Graduate School of Integrated Basic
Sciences, Nihon University, 2College of Industrial Technology, Nihon University)
Maximizing Local Information Transfer in Boolean Networks
Taichi Haruna1, Kohei Nakajima2,3 (1Tokyo Woman's Christian University, 2The University of Tokyo,
3PRESTO, JST)
局所情報流最大化に駆動される時空間ダイナミクス
Spatiotemporal dynamics driven by maximization of local information transfer
Kohei Nakajima1,3, Taichi Haruna2 (1The University of Tokyo, 2Tokyo Woman's Christian University, 3JST
PRESTO)
Spatial Cooperation between DNA and Actin in Micro-Confinement Generated throughSpontaneous Phase Segregation
Hiroki Sakuta1, Naoki Nakatani1, Masahito Hayashi2, Kingo Takiguchi3, Kanta Tsumoto4,
Kenichi Yoshikawa1 (1Grad. Sch. Life Med. Sci., Doshisha Univ., 2Center of Brain Sci., RIKEN, 3Grad.
Sch. Sci., Nagoya Univ., 4Grad. Sch. Eng., Mie Univ.)
Theoretical model of dynamics of epithelial tissue with cellular chirality
Takaki Yamamoto1, Tetsuya Hiraiwa2, Tatsuo Shibata1 (1Riken, Lab. Phys. Biol., 2Univ. Tokyo, Sci. Phys.)
Analysis of soliton-like collective migration of non-chemotactic dictyostelium cells
Masayuki Hayakawa1, Hidekazu Kuwayama2, Yuko Wada1, Tatsuo Shibata1 (1BDR, Riken, 2Faculty ofLife and Environmental Sciences, University of Tsukuba)
多電極システムによる心筋細胞ネットワークにおける拍動伝導の計測技術の開発
Development of a method to track conductions in cardiomyocyte network with a multi-electrodesystemKazufumi Sakamoto1, Natsuki Seki1, Shota Aoki2, Naoki Takahashi2, Masao Odaka3,4, Kenji Matsuura3,4,
Akihiro Hattori3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ.,
2Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives,
Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore)– S172 –生命情報科学／Bioinformatics
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タンパク質複合体構造モデリングの評価のためのベンチマークデータセット
A large decoy dataset for protein-protein docking model quality assessment
Takanori Hayashi1, Masahito Ohue1, Juliette Martin2, Guillaume Launay2, Yuri Matsuzaki3,
Nobuyuki Uchikoga3, Yutaka Akiyama1,3 (1Sch Computing, Tokyo Tech, 2MMSB, CNRS, Univ Lyon,
3ACLS, Tokyo Tech)
Sequence profile for protein design based on database analysis of backbone environment
Shintaro Minami, Rie Koga, Nobuyasu Koga (NINS, ExCELLS)
Development of a method for predicting pathogenicity of missense variants incorporatingsupramolecular structural information
Atsushi Hijikata, Masafumi Shionyu, Tsuyoshi Shirai (Nagahama Inst. Bio-Sci. Tech.)
Performance improvement of the method for large-scale structural comparison of protein
pockets
Tsukasa Nakamura1,2, Kentaro Tomii1,2 (1CBMS, GSFS, Univ. Tokyo, 2AIRC, AIST)
ヒト機能未知スプライシングアイソフォームの特徴解析
Analysis of characteristics of function-unknown splicing isoforms in human
Masafumi Shionyu, Atsushi Hijikata (Fac. Biosci., Nagahama Inst. Bio-Sci. Tech.)Characterizing SLC transporters by sequence and functional networks
Hafumi Nishi1, Yuya Hanazono1, Hitoshi Yamagata2, Kengo Kinoshita1 (1Grad. Sch. Info. Sci., Tohoku
Univ., 2Adv. Res. Lab., Canon Medical Systems Corp.)
肺癌細胞の発現変動遺伝子を対象としたクラスタセントロイド間の相関ネットワーク
Correlated network by cluster centroids for differentially expressed genes in lung cancer cell
Kohei Misu1, Masahiro Sugimoto2, Takanori Sasaki1 (1Grad. Sch. Adv. Math. Sci., Meiji Univ., 2RDCMIT,
Tokyo Med. Univ.)
機能に関する選択シミュレーションにおける P-loop 蛋白質構造の多様化
Diversification of P-loop protein structure simulated by imposing the functional requirement as aselection pressure
Kohei Inukai, Masaki Sasai, George Chikenji (Department of Engineering, Nagoya University)
数理生物学／Mathematical biology

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脳の階差成長による皺形成シミュレーション
Winkling simulation of differential growth of brain
Katsuyoshi Matsushita1, Kazuya Horibe1, Naoya Kamamoto1, Ken-ichi Hironaka2, Koichi Fujimoto1(1Depertment of Biological Science, Graduate School of Science, Osaka University, 2Department of
Biological Sciences, Graduate School of Science, University of Tokyo)
機械学習を利用した集団内細胞行動解析
System analysis of cellular behavior with machine learning during collective cell migration
Moegi Marumoto1,2, Masaya Hagiwara1 (1N2RI, Osaka Pref. Univ., 2Dept. of Biol. Sci., Osaka Pref. Univ.)
多細胞の協調的な運動時における細胞の複雑な変形のフェーズフィールドモデル
Phase-field modeling of complex cell deformation and multi-cellular motion
Daisuke Imoto1, Nen Saito4, Satoshi Sawai1,2,3 (1Dept Basic Sci, Grad School of Arts and Sci, Univ ofTokyo, 2Research Ctr for Complex Systems Biology, Univ of Tokyo, 3JST PRESTO, School of Science, The
University of Tokyo,, 4Universal Biology Institute, The University of Tokyo)
不正確な素子から正確な情報伝達をおこなうためのネットワーク構造と協同性
Cooperative reliable response from sloppy gene expression dynamics
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A data-driven model for collective cell motion in Dictyostelium discoideum
Keizaburo Nishikino1, Ryo Yokota2, Tetsuya J. Kobayashi1,2,3 (1EEIS, Univ Tokyo, 2IIS, Univ Tokyo, 3IST,Univ Tokyo)
ATPase activity of individual KaiC molecules decisively influences the ensemble-level oscillationof cyanobacterial KaiABC clock
Sumita Das1,2, Tomoki P. Terada1,2, Masaki Sasai1,2 (1Deparment of Computational Science andEngineering, Nagoya University, Nagoya, 2Department of Applied Physics, Nagoya University, Nagoya)
Effects of the binding domain of Pin1 interacting with proteins of variable conformations
Romain Amyot, Yuichi Togashi (Grad. Sch. Sci., Univ. Hiroshima)
Experimental Validation of a Mathematical Model of ErbB Receptor Signaling to Cell Cycle
Kyoichi Ebata, Hiroaki Imoto, Kazunari Iwamoto, Shigeyuki Magi, Suxiang Zhang, Mariko Okada (IPR,
Osaka Univ.)
蟻の死骸の山の形成プロセスにおける一考察
Ant Cemeteries Grow via the Ambiguous Local Environment
Tomoko Sakiyama (Grad. Sch. Nat. Sci. Tech., Univ. Okayama)
Reduction of a Markov operator representing the dynamics of stochastic neuronal model bysparse discrete cosine transform
Takanobu Yamanobe (Hokkaido University School of Medicine)
アルツハイマー病とシロスタゾール －傾向スコアを用いた医療費の検討－
Alzheimer's disease and cilostazol -medical cost through propensity scoreIzumi Kuboyama, Susumu Ito, Toshiaki Kaminaka, Katsuhiko Hata (Kokushikan University)
Coupled epigenetic and genetic network gives rise to a probability landscape with eddy currents
Bhaswati Bhattacharyya, Masaki Sasai (Department of Computational Science and Engineering, Nagoya
University)
細胞生物学／Cell Biology

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SPI-2 感染装置先端蛋白質 SseB の集合体形成
Assembly characteristics of SseB, a putative tip protein of the SPI-2 injectisome
Takumi Tsujimoto1, Yuki Yamanaka2, Linda J Kenny2, Katsumi Imada1 (1Grad. Sch. of Sci., Osaka Univ.,
2MBI., NUS.)
GPCR ダイマーを構成する一部の分子は、リガンド刺激前に自発的に活性化している
Spontaneous activation in a transient GPCR dimer before ligation as revealed by dual-channel
single fluorescent molecule imaging
Rinshi Kasai (Inst. Front. Life. Med. Sci., Kyoto Univ.)
MCF 細胞内における p52Shc の Grb2 シグナル伝達制御
Regulation of Grb2 signaling dynamics by p52Shc scaffold protein in MCF7 cells
Ryo Yoshizawa1,2, Nobuhisa Umeki2, Masataka Yanagawa2, Masayuki Murata1, Yasushi Sako2(1Grad.sch.arts and ahi., the univ. Tokyo, 2Wako Inst., Riken)
RhoA activation inhibits proliferation of skin cancer cells
Oleg Dobrokhotov1,2, Atsushi Enomoto3, Masaki Sunagawa3, Masahide Takahashi3, Mikhail Samsonov4,
Masahiro Sokabe2, Hiroaki Hirata1,2 (1R-Pharm Japan, 2Mechanobiology Lab., Grad. Sch. Med., Nagoya
Univ., 3Dept. Pathology, Grad. Sch. Med., Nagoya Univ., 4R-Pharm)
Size-dependent beating rate changes of cardiomyocyte clusters by environmental thermalchanges
Wei Wang, Tomoyuki Kaneko (LaRC, FB, Grad.Sch., Hosei Univ.)
心筋細胞メカニクスに NADPH オキシダーゼ 4 が及ぼす影響
Single cell mechanics effects of NADPH oxidase (NOX) 4 in mouse ventricular cardiomyocytes
Keiko Kaihara, Gentaro Iribe, Hiroaki Kai, Keiji Naruse (Dept Cardio Physiol, Grad Sch med, Okayama
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1 細胞レベルの電気信号伝導速度計測に向けた心筋細胞ネットワーク再構築
Reconstruction of cardiomyocyte network for measuring the signal conduction velocity at single
cell level
Koki Fujii, Tomoyuki Kaneko (LaRC, FB, Hosei univ)
間葉系幹細胞の温度依存形態振動に伴うメカノシグナル転写因子の核ー細胞質シャトリング
Nucleocytoplasmic shuttling of the mechanotransducing proteins in temperature-dependent
shape-oscillating mesenchymal stem cells
Sayaka Masaike1, Satoru Kidoaki2 (1Grad. Sch. Eng., Kyushu Univ., 2IMCE, Kyushu Univ.)
iPS 細胞は最適弾性率を持つハイドロゲル表面に移動し増殖する
iPS cells move toward and efficiently proliferate on the hydrogel surface with optimal elasticity
Mengfan Wang1, Satoru Kidoaki2 (1Grad. Sch. Eng., Kyushu Univ., 2IMCE, Kyushu Univ.)
ハイドロゲル上でのマスト細胞の刺激応答
Inhibition of degranulation in mast cells cultured on hydrogel
Atsushi Shiki, Yoshikazu Inoh, Satoru Yokawa, Tadahide Furuno (Sch. Pharm., Univ. Aichi Gakuin)
三次元細胞構造体の構築：高分子混雑環境下におけるレーザーピンセットの活用
Constructing 3D Cellular Assembly: Laser Tweezering under Depletion Effect on Albumin
Solution
Ritsuki Ito, Kakehiro Yamazaki, Satoshi Kishimoto, Takahiro Kenmotsu, Koichiro Sadakane,
Kenichi Yoshikawa (Faculty of Biological and Medical Sciences, Doshisha University)
Investigation for the crosstalk mechanism of two damping oscillators, p38 MAP kinase and NFκB
Hiroki Michida, Minami Ando, Shigeyuki Magi, Kazunari Iwamoto, Mariko Okada (IPR Osaka Univ.)
多繊毛上皮細胞の基底小体の配列・配向秩序化の数理モデル
Mathematical model for alignment and orientation order of basal bodies in a multi-ciliated cellToshinori Namba1, Shuji Ishihara1,2 (1Graduate School of Arts and Sciences, The University of Tokyo,
2Universal Biology Institute, The University of Tokyo)
隣接させた心臓組織片の同期化プロセスの解明
Synchronization processes of cardiac tissue fragment pair and the regional differences in theheart
Shin Arai1, Tomoyuki Kaneko2, Toshiyuki Mitsui1 (1Grad. Sch. of Sci. & Eng., Aoyama Gakuin Univ.,
2LaRC, Grad. Sci. Eng., Hosei Univ.)
長期的機械刺激による心筋細胞集合体への影響
Long-term influence of external mechanical stimulus on cardiomyocyte aggregations
Takashi Miyazawa, Shin Arai, Takahiro Uehara, Shogo Yahagi, Toshiyuki Mitsui (Grad. Sch. of Sci. &Eng., Aoyama Gakuin Univ.)
Exploring the basic law that determines the shape of fast moving cells
Gen Honda1, Satoshi Sawai1,2 (1Department of Basic Science, Graduate School of Arts and Sciences,
University of Tokyo, 2Research Center for Complex Systems Biology, Graduate School of Arts and Sciences,
University of Tokyo)
AFM を用いた腫瘍微小環境を構成する細胞間の接着剥離力と細胞接触時間の関係評価
Relationship between detachment force and contact time for cells making up tumor
microenvironments measured by AFM
Kenta Ishibashi1, Tomoko Okada2, Chikashi Nakamura1,2, Hyonchol Kim1,2 (1Grad. Sch. Eng., Tokyo
Univ. Agric. Technol., 2Biomed. Res. Inst., AIST)
生物発光イメージング法を用いた ECM と接着したマスト細胞の脱顆粒の可視化解析
Video-Rate Bioluminescence Imaging of Degranulation of Mast Cells Attached to theExtracellular Matrix
Satoru Yokawa1, Takahiro Suzuki2, Ayumi Hayashi1, Satoshi Inouye3, Yoshikazu Inoh1, Tadahide Furuno1(1Sch. Pharm., Aichi Gakuin Univ., 2Sch. Dent., Aichi Gakuin Univ., 3JNC Co., Yokohama.)– S175 –3Pos319

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FERT 法による走化性受容体クラスター活性とべん毛モーター回転の１細胞同時計測
Simultaneous measurement of chemoreceptor array’s activity and the flagellar motor rotation
utilizing single cell FRET
Hajime Fukuoka, Tatsuya Yamakoshi, Sarina Nishimura, Yong-Suk Che, Akihiko Ishijima (Grad. Sch.
Frontier Biosci., Osaka Univ.)
大腸菌におけるべん毛の回転方向と CheY の細胞内動態の同時計測
Simultaneous measurement of flagellar motor rotation and dynamics of CheY in a single E.coli
cellTatsuya Yamakoshi, Yong-Suk Che, Akihiko Ishijima, Hajime Fukuoka (Grad.Sch.Frontier.Osaka Univ.)
T 細胞シグナルの超解像イメージング法の開発
Development of the superresolutional imaging in T cell signaling
Hiroaki Machiyama, Ei Wakamatsu, Tadashi Yokosuka (Dept. Immunol., Tokyo Med. Univ.)
磁性細菌の走磁性運動におけるべん毛回転運動の生細胞イメージング
Live-cell imaging of flagellar rotation in magnetotactic bacterial cell during magneto-aerotaxis
Yuta Takaoka1, Azuma Taoka1, Yoshihiro Fukumori2 (1Grad. Sch. of Nat. Sci. and Tech., Kanazawa
Univ., 2Vice President, Kanazawa Univ.)
高速 AFM による細胞表面の分子イメージング
Molecular imaging of dynamic process on bacterial cell surface by high speed AFM
Hayato Yamashita1,2, Azuma Taoka3,4, Masayuki Abe1 (1Grad. Sch. of Eng. Sci., Osaka Univ., 2PRESTO,
JST, 3Grad. Sch. of Nat. Sci. & Tech., Kanazawa Univ., 4Bio-AFM Frontier Research Center, Kanazawa
Univ.)
魚類ケラトサイトの遊走メカニズムに微小管は必要ない
Microtubules are not required for crawling migration of keratocytes
Hitomi Nakashima, Chika Okimura, Yoshiaki Iwadate (Fac. Sci., Yamaguchi Univ.)
神経突起との接着による膵島 α 細胞の細胞内顆粒動態とグルカゴン分泌の抑制
Decreased intracellular granule movement and glucagon secretion in pancreatic α cells
attached to superior cervical ganglion neurites
Tadahide Furuno1, Satoru Yokawa1, Kiyoto Watabe1, Yoshikazu Inoh1, Takahiro Suzuki2 (1Sch. Pharm.,
Aichi Gakuin Univ., 2Sch. Dent., Aichi Gakuin Univ.)
赤外線レーザー照射刺激による心筋細胞拍動変化の物理的要因
Physical effect on beating rate change of cardiomyocytes induced by infrared laser irradiation
Yukino Motohashi, Kento Nozawa, Maki Ishii, Tomoyuki Kaneko (LaRC, FB, Hosei univ.)
100 分子ほどの膜貫通足場タンパク LAT がマスト細胞の免疫反応を担っている
Only ~100 copies of a transmembrane scaffolding protein LAT are responsible in the immune
response in mast cells
Koichiro M. Hirosawa1, Nao Hiramoto-Yamaki2, Shohei Nozaki3, Taka A. Tsunoyama4, Bo Tang5,
Kenichi G.N. Suzuki1,2, Kazuhisa Nakayama3, Takahiro K. Fujiwara2, Akihiro Kusumi4 (1G-CHAIN, Gifu
Univ., 2iCeMS, Kyoto Univ., 3Grad. Sch. Pharma., Kyoto Univ., 4OIST, 5Wuhan University)
バイオエンジニアリング／Bioengineering

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Stiffness measurement of cell by using micro-hand systems with plate shape end effector
Masaru Kojima1, Taisei Tanaka1, Yasushi Mae1, Toshihiko Ogura2, Tatsuo Arai3,4 (1Grad. Sch. Eng. Sci.,
Osaka Univ., 2IDAC, Tohoku Univ., 3Glob. Alliance Lab., The Univ. of Electro-Communications, 4Beijing
Inst. of Tech.)
油中水滴界面を利用した DNA ハイドロゲルマイクロカプセルの構築
Construction of DNA hydrogel microcapsules using water-in-oil droplet interface
Yuji Nakashima, Yusuke Sato, Yu Kasahara, Masahiro Takinoue (Dept. of com. sci., TITech)– S176 –3Pos403

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DNA でつくるシグナル伝達機構の実現に向けた DNA 生成反応回路の構築
Construction of a DNA Generation Circuit toward Engineering of DNA-based Signal
Transduction Systems
Ken Komiya, Chizuru Noda, Masayuki Yamamura (Sch. Comp., Tokyo Tech.)
iPS 細胞の心筋分化誘導における血管内皮細胞の影響
Effect of vascular endothelial cells on cardiac differentiation of iPS cells
Chika Tada, Ken Takahashi, Masatoshi Morimatsu, Keiji Naruse (Grad. Sch Med Dent Pharm Sci.,
Okayama Univ.)
Evaluation of membrane shape deformation of giant vesicles prepared by droplet transfer
methodMasamune Morita, Naohiro Noda (Biomed. Res. Inst., AIST)
細胞外電位測定による心筋細胞集団と心臓組織片の拍動同期過程の解析
Analysis of signal synchronization process between dispersed cardiomyocyte and cardiac
tissue piece by measuring extracellular potential
Toru Nakamura, Chiho Nihei, Tomoyuki Kaneko (Laboratory for Reconstructive Cell biology,
Department of Frontier Bioscience, Hosei University)
新規心毒性検査技術を目指した心臓組織片の細胞外電位計測
Measurement of Extracellular Potential on Heart Tissue for Novel Cardiotoxicity Test
Ryohei Kobayashi, Koji Emura, Tomoyuki Kaneko (LaRC,FB,Hosei Univ.)
細胞外電位計測による心臓組織片の拍動同期解析
Analysis of beating synchronization of cardiac tissue pieces by field potential measurement
Yousuke Kamei1, Toshiyuki Mitsui2, Tomoyuki Kaneko1 (1LaRC, FB, Hosei Univ., 2Dept. Math. Phys.,Col. Sci. Eng., Aoyama Univ.)
血中循環腫瘍細胞をサイズ分画するための流路チップデザインの加工工程における形状の転写の加工精度の定量的評価
Quantitative evaluation of preciseness in design copy in microfabrication procedures ofcirculating tumor cell cluster size-filtration
Ayako Kawai1, Moe Iwamura2, Kenji Matsuura3,4, Akihiro Hattori3,4, Masao Odaka3,4, Kenji Yasuda1,2,3,4(1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Grad. Sch.
Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda Univ., 4WASEDA Biosci. Res. Ins. in
Singapore)
血中循環腫瘍細胞を選択回収するサイズ分画機能を備えた画像認識型セルソーターの開発
Development of size filtration-imaging cell sorter for real time selective collection of circulatingtumor cells (CTCs) in blood
Moe Iwamura1, Kenji Matsuura3,4, Ayako Kawai2, Masao Odaka3,4, Akihiro Hattori3,4, Kenji Yasuda1,2,3,4(1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Sch.
Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives, Waseda Univ, 4WASEDA Biosci. Res. Ins. in
Singapore (WABIOS))
単一細胞分析のための Ba2 + / Ca2 +アルギン酸微小滴からの選択的な細胞回収方法の検討
Selective digestion of Ba2+/Ca2+ alginate microdroplets for single-cell-analysis
Masao Odaka1,2, Moe Iwamura3, Ayako Kawai4, Akihiro Hattori1,2, Kenji Matsuura1,2, Kenji Yasuda1,2,3,4(1Org. Univ. Res. Initiatives, Waseda Univ., 2WASEDA Biosci. Res. Ins. in Singapore, 3Dept. Pure & Appl.
Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 4Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng.,
Waseda Univ.)
Environment-dependent self-assembly of DNA nanostructures on phase-separated lipid bilayer
membranes
Yusuke Sato1, Masayuki Endo2,3, Masamune Morita4, Masahiro Takinoue1, Hiroshi Sugiyama2,3,
Satoshi Murata5, Shin-ichiro M. Nomura5, Yuki Suzuki5,6 (1Dept. Comput. Sci., Tokyo Tech, 2iCeMS, Kyoto
Univ., 3Grad. Sch. Sci., Kyoto Univ., 4Biomed. Res. Inst., AIST, 5Grad. Sch. Eng., Tohoku Univ., 6Fronti.
Res. Inst. Interdiscrip. Sci., Tohoku Univ.)– S177 –3Pos413

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血管新生の遺伝子発現解析のためのマトリゲル構造を用いた発芽的血管内皮細胞の回収方法の開発Development of sprouting vascular endothelial cell collection method using flexible design ofMatrigel for expression analysis
Yuki Yamanaka1, Kento Iida1, Ryuji Takano2, Hiromichi Hashimoto2, Masao Odaka3,4, Akihiro Hattori3,4,
Kenji Matsuura3,4, Kenji Yasuda1,2,3,4 (1Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda
Univ., 2Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 3Org. Univ. Res. Initiatives,
Waseda Univ., 4WASEDA Biosci. Res. Ins. in Singapore)
交流磁場によるフェリチン内合成マグネタイトナノ粒子の加熱
Heating effect of magnetite nanoparticles synthesized in the ferritin cavity by alternating
magnetic field
Daisuke Katayama1, Hideyuki Yoshimura2 (1Grad. Sch. Sci Eng. Phys, Univ. Meiji, 2Sci Eng. Phys, Univ.
Meiji)
Insertion of cancer cell specific binding peptide into ferritin
Naoki Takashima1, Hideyuki Yhoshimura2, Tomoko Kanamaru2 (1Grad. Sch. Sci/Eng Phy. Univ. Meiji,
2Sci/Eng Phy. Univ. Meiji)
蛍光・発光タンパク質に基づくマイクロディスプレイ
Micro-display devices based on fluorescence and bioluminescence proteins
Kosuke Hama1, Trisha.D Farha1, Mieko Imayasu1, Ken-ichi Shinohara1, Yuichi Hiratsuka1,
Atsushi Miyawaki2, Hidekazu Tsutsui1,2 (1JAIST, material Sci, 2Wako Inst., Riken)
Photo-regulation of Small GTPase Ras using Photochromic SOS-Peptide
Masahiro Kuboyama1, Nobuyuki Nishibe1, Kenichi Taii1, Kazunori Kondo2, Shinsaku Maruta1 (1Dept. of
Bioinformatics, Graduate School of Engineering, Soka University, 2Department of Science andEngineering, Faculty of Science and Engineering, Soka University)
High-throughput in vitro selection method for obtaining peptide agonists of G protein-coupled
receptors
Anna Matsueda1, Takashi Sakurai1, Ryo Iizuka1, Yasuyuki Nakamura2, Jun Ishii3, Akihiko Kondo2,
Ayaka Iguchi4, Dong Hyun Yoon5, Tetsushi Sekiguchi5, Shuichi Shoji4, Yuu Fujimura6, Jin Akagi6,
Masayuki Ishige6, Takashi Funatsu1 (1Grad. Sch. of Pharm. Sci., The Univ. of Tokyo, 2Grad. Sch. of Eng.,
Kobe Univ., 3Org. of Adv. Sci. and Technol., Kobe Univ., 4Dept. of Nanosci. and Nanoeng., Waseda Univ.,
5Res. Org. for Nano & Life Innov., Waseda Univ., 6On-chip Biotechnol. Co., Ltd.)
Droplet-based microfluidic screening for obtaining microbes producing macromoleculedegrading enzymes
Ryo Iizuka1, Kai Saito1, Eiji Shigihara1, Wataru Kawakubo2, Daiki Tanaka3, Dong Hyun Yoon3,
Tetsushi Sekiguchi3, Shuichi Shoji2, Mei Ito4, Yuji Hatada4, Takashi Funatsu1 (1Grad. Sch. of Pharm. Sci.,
The Univ. of Tokyo, 2Dept. of Nanosci. and Nanoeng., Waseda Univ., 3Res. Org. for Nano & Life Innov.,
Waseda Univ., 4Dept. of Life Sci. and Green Chem., Saitama Inst. of Technol.)
統合情報理論に基づく意識を持つ DNA ネットワークの設計と解析
Design and analysis of DNA network with consciousness based on integrated information
theoryHiroki Watanabe1, Ryuji Kawano2, Masahiro Takinoue1 (1Dept. Compt. Sci., Tokyo Tech, 2Dept. Bio. Life
Sci., Tokyo Univ. Agri. Tech.)
The way to the perfect observation!! ~Research of drone that mimics the birds~
Ayumu Kuroda (Tokyo Metropolitan high sch .,F-pro)– S178 –