耳鼻咽喉科･頭頸部外科学講座【研究プロジェクト名および概要】
１．頭頸部腫瘍学①

頭頸部腫瘍の診療と治療②

頭頸部腫瘍における網羅的遺伝子解析③頭頸部腫瘍発症マウスモデルの作成

２．喉頭科学① 声帯瘢痕生成機序の解明と新規薬物治療法の開発② 加齢による音声障害に対する新規治療法の開発③ 機能性発声障害と声帯振動解析④ 痙攣性発声障害の病態解明と新たな治療法の開発⑤ エビデンスに基づく嚥下障害治療法の確立
３．耳科学① 遺伝性難聴の根本的治療法の開発② 内耳発生メカニズムの解明③ 加齢性難聴の治療法の開発④ ミトコンドリア異常による難聴の病態解明【研究者および大学院生】（研究プロジェクト）

教授

折田

頼尚

（研究の統括）講師

村上大造（１－①②③）宮丸 悟（１－①②③、２－①②⑤）

伊勢桃子（１－①②、３－①②③④）

西本康兵（１－①②③、２－①③④）

竹田 大樹（１－①②、３－①②③④）

宮本祐亮（１－①②③）

倉岡薫瑠子（２－①②③④⑤）

齋藤

陽元、伊東山舞、村上

医員（パート）菅村真由美、髙村晴香助

医教員

大学院生（博士課程）

竹本梨沙（１－①②③）【連絡先】
TEL：０９６－３７３－５２５５【ホームページ】
http://kumamoto-ent.com/

瑛、寺田夕希、古庄隼也、幸野香織

【発表論文】
1.

Nishimoto K, Toya Y, Davis CR, Tanumihardjo SA, Welham NV. Dynamics of vitamin A uptake, storage, andutilization in vocal fold mucosa. Molecular metabolism 2020; 40: 101025.

2.

Hirota K, Nishimoto K, Kumai Y, Miyamaru S, Miyamoto T, Saito H, Ise M, Murakami D, Orita Y. Swallowing
dysfunction following surgery for well-differentiated thyroid cancer with extrathyroid invasion. Int J Clin Oncol
2020; 25: 1921-1927.

3.

Toya R, Saito T, Matsuyama T, Watakabe T, Yamaguchi K, Murakami D, Honda Y, Mizutari S, Orita Y, Oya N.
QUAD shot: an effective cyclical hypofractionated palliative radiotherapy for salivary gland carcinoma. BJR Case
Rep 2020; 6: 20190132.

4.

Tachibana T, Sasaki T, Wani Y, Komatsubara Y, Kuroda K, Naoi Y, Gion Y, Orita Y, Nishizaki K, Sato Y.
Methotrexate-Associated lymphoproliferative disorders mimicking granulomatosis with polyangiitis: aradiological diagnostic challenge. Ear Nose Throat J 2020; 145561320970685.

5.

Tachibana T, Orita Y, Wani Y, Komatsubara Y, Kuroda K, Naoi Y, Gion Y, Makino T, Nishizaki K, Sato Y.
Application of lip biopsy for the histological diagnosis of immunoglobulin G4-related disease. Ear Nose Throat J2020; 145561320971932.

6.

Miyake S, Miwa T, Yoneda G, Kanemaru A, Saito H, Minoda R, Orita Y, Saito H, Jono H. Relationship betweenclinicopathological characteristics and CYLD expression in patients with cholesteatoma. PLos One 2020; 15:e0240216.

7.

Akisada N, Nishimoto K, Takao S, Gion Y, Marunaka H, Tachibana T, Makino T, Miki K, Akagi Y, Tsumura M,Toji T, Yoshino T, Nishizaki K, Orita Y, Sato Y. PD-L1 expression in tongue squamous cell carcinoma Med Mol
Morphol 2021; 54: 52-59.

8.

Komatsubara Y, Tachibana T, Orita Y, Makino T, Kuroda K, Naoi Y, Kataoka Y, Sato Y, Kariya S, Nishizaki K.
Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglotticcancer. Acta Otolaryngol 2020; 140: 773-778.

9.

Toya R, Saito T, Yamaguchi K, Matsuyama T, Watakabe T, Matsumoto T, Yoshida R, Hirosue A, Murakami D,Orita Y, Nakayama T, Oya N. Hypofractionated palliative volumetric modulated arc radiotherapy with theradiation oncology study group 8502 “QUAD shot” regimen for incurable head and neck cancer. Radiat Oncol
2020; 15: 123.

10. Makino T, Tachibana T, Kariya S, Matsui Y, Matsuzaki H, Fujimoto S, Orita Y, Katsui K, Hiraki T, Sato Y,Kanazawa S, Nishizaki K. Pathological evaluation of radiotherapy and concomitant intraarterial cisplatin formaxillary sinus cancer. Auris Nasus Larynx 2020; 47: 881-886.

11. Toya R, Saito T, Matsuyama T, Kai Y, Shiraishi S, Murakami D, Yoshida R, Watakabe T, Sakamoto F, Tsuda N,Arimura H, Orita Y, Nakayama H, Oya N. Diagnostic Value of FDG-PET/CT for the Identification of Extranodal
Extension in Patients With Head and Neck Squamous Cell Carcinoma. Anticancer Res 2020; 40: 2073-2077.

12. Gion Y, Okano M, Koyama T, Oura T, Nishikori A, Orita Y, Tachibana T, Marunaka H, Makino T, Nishizaki K,Sato Y. Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis. Int JMol Sci 2020; 21: 1843.

13. Makino T, Orita Y, Gion Y, Tachibana T, Takao S, Marunaka H, Miki K, Akisada N, Akagi Y, Yoshino T,
Nishizaki K, Sato Y. MACC1 expression is an indicator of recurrence in early-stage glottic cancer. Jpn J ClinOncol 2020; 50: 392-398.

14. Chin-Ju H , Ying-Chang Lu, Yi-Hsiu Tsai, Haw-Yuan Cheng, Hiroki Takeda, Chun-Ying Huang, Ru Xiao,Chuan-Jen Hsu, Jin-Wu Tsai, Luk H Vandenberghe, Chen-Chi Wu, Yen-Fu Cheng. Efficient in Utero Gene
Transfer to the Mammalian Inner Ears by the Synthetic Adeno-Associated Viral Vector Anc80L65. Mol TherMethods Clin Dev 2020; 18: 493-500.
15. Sato Y, Okamoto I, Kameyama H, Kudoh S, Saito H, Sanada M, Kudo N, Wakimoto J, Fujino K, Ikematsu Y,Tanaka K, Nishikawa A, Sakaguchi R, Ito T. Integrated Immunohistochemical Study on Small-Cell Carcinoma of
the Lung Focusing on Transcription and Co-Transcription Factors. Diagnostics (Basel) 2020; 10: 949.

16. Tenjin Y, Matsuura K, Kudoh S, Usuki S, Yamada T, Matsuo A, Sato Y, Saito H, Fujino K, Wakimoto J, Ichimura T,Kohrogi H, Sakagami T, Niwa H, Ito T. Distinct transcriptional programs of SOX2 in different types of small celllung cancers. Lab Invest 2020; 100: 1575-1588.

17. Miyamaru S, Murakami D, Nishimoto K, Saito H, Miyamoto Y, Hirota K, Ise M, Orita Y. Treatment Outcomes ofPulmonary Metastases from Head and Neck Squamous Cell Carcinoma. Acta Med Okayama 2021; 75: 31-37.

18. Miyamoto T, Kumai Y, Matsubara K, Kodama N, Satoh C, Orita Y. Different types of dysphagia alleviated by thechin-down position. Auris Nasus Larynx 2021; S0385-8146(21)00066-3.

19. Miwa T, Saito H, Akita H. Lipid nanoparticles-encapsulated brain-derived neurotrophic factor mRNA delivered
through the round window niche in the cochleae of guinea pigs. Exp Brain Res 2021; 239: 425-433.