Final Scientific Program of the 6th International Calicivirus Conference - Oct 9-13, 2016

Sep 30, 2016

Sunday October 9
1:00 - 5 PM

Conference Registration

5:00 PM
5:15 - 6:15 PM

Welcome and Introduction: Jan Vinjé
Mary K. Estes - Baylor College of Medicine - Houston, TX - USA (Albert Kapikian Lecture)
Human Norovirus Mysteries - Old and New
Welcome reception with drinks and Low Country snacks

6:15 - 8 PM

Monday October 10
7:00 - 9:00 AM
7:15 - 8:15 AM
7:00 - 9:00 AM

set up posters Day 1
Continental breakfast
Conference Registration
session 1

8:00 - 8:05 AM
8:05 - 8:20 AM
8:20 - 8:35 AM
8:35 - 8:50 AM
8:50 - 9:05 AM
9:05 - 9:20 AM
9:20 - 9:35 AM
9:35 - 10:00 AM
10:00 - 10:30 AM
10:30 - 11:00 AM
11:00 - 12:30 PM

Novel Models to Culture Human Norovirus

Moderators: Jacques LePendu, Lee-Ann Jaykus

Introduction session 1
Melissa Jones - University of Florida - Gainesville, FL - USA
Identification of Conditions Regulating Human Norovirus Replication in B cells
Christiane Wobus - University of Michigan - Ann Arbor, MI - USA
Human Norovirus Infection of Primary Human B-cells
Khalil Ettayebi - Baylor College of Medicine - Houston, TX - USA
Strain-Specific Human Norovirus Replication in Biologically Relevant Human Enteroid Cultures
Akita Fujimoto - National Institute of Infectious Diseases - Tokyo - Japan
Cultivation of Human Norovirus using Human Duodenal Organoids
Dennise de Jesus Diaz - National Institutes of Health - Bethesda, MD - USA
Screening Infectious Human Noroviruses Using a Human-Derived Small Intestine Enteroid Cell Culture System
Veronica Costantini - Centers for Disease Control and Prevention - Atlanta, GA - USA
Human Norovirus Replication in Human Intestinal Enteroids as a Model to Evaluate Virus Inactivation
General Discussion Culture Models- coffee/ tea breaksession 2 Virus structure, entry and replication
Moderators: Bidadi Prasad, Ana Lorena Gutiérrez - Escolano

State of the Art: Göran Larson - University of Gothenburg, Gothenburg, Sweden
Norovirus Binding to Glycosphingolipids
Kei Haga - National Institute of Infectious Diseases -Tokyo - Japan
Identification of the Functional Receptor for Murine Norovirus
Stanislav Sosnovtsev - National Institutes of Health - Bethesda, MD - USA
Hom-1 entry: it takes Two to Tango
Umesh Karandikar - Baylor College of Medicine - Houston, TX - USAIntestinal Cell Types that Support Replication of Human Norovirus in Intestinal Biopsies from Immunocompromised Patients

Final Scientific Program of the 6th International Calicivirus Conference - Oct 9-13, 2016

12:30 - 2:00 PM

Jia Lu - University of Cambridge - Cambridge - UK
Rational Attenuation of Murine Norovirus by Mutations in the Multifunctional Capsid Shell Domain
José Mora-Heredia - CINVESTAV-IPN - México City - México
Effect of Feline Calicivirus Infection in the Integrity of Nuclear Pore Protein Nup270
Sreejesh Shanker - Baylor College of Medicine - Houston, TX - USA
Structural Basis for Norovirus Neutralization by an HBGA Blocking Human IgA Antibody- lunch
session 3 Pathogenesis and Immunity

2:00 - 2:30 PM

State of the Art: Stephanie Karst - University of Florida - USA

2:30 - 4:00 PMRalph Baric - University of North Carolina - Chapel Hill, NC - USA
New Mechanisms of GII.4 Immune EvasionSep 30, 2016

Moderators: Kim Green, Kazuhiro Katayama

The Influence of Commensal Bacteria on Norovirus Cell Tropism and Immunity

4:30 - 6:00 PM
6:00 - 6:30 PM

Hiroshi Ushijima - Nihon University School of Medicine - Tokyo - JapanImmune Response against Different Genotypes of Norovirus in Two Adults with Recurrent Infection
Edward Emmott - University of Cambridge - Cambridge - UKNorovirus-mediated Modification of Translational Landscape via Virus and Host-induced Cleavage of Translation Initiation Factors
Vernon Ward - University of Otago - Dunedin - New Zealand
A Murine Norovirus Protein Manipulates the Host Cell Cycle
Daniel Enosi Tuipulotu - University of New South Wales - Sydney - Australia
Transcriptome Profiling of Murine Norovirus-infected Macrophages reveals Modulation of Host Innate Immunity
Aminu Jahun - University of Cambridge - Cambridge - UK
Modulation of Interferon Induction by the Murine Norovirus Virulence Factor 1 (VF1) Protein- Day 1 poster view with cheese and wine- remove posters Day 1

Tuesday October 11
7:00 - 9:00 AM
7:15 - 8:15 AM

set up posters Day 2
Continental breakfast
session 4

8:00 - 8:30 AM
8:30 - 10:15 AM

Glycans and Novel Approaches to Study Caliciviruses

Moderators: Christiane Wobus, Ian Goodfellow

State of the Art 1: Ken Cadwell - New York University - Newark, NY - USA
Norovirus Infection and the Gut Microbiome
Jesus Rodríguez-Díaz - University of Valencia - Valencia, Spain
Role of Secretor Status and Intestinal Microbiota in the Susceptibility to Norovirus and Rotavirus Infections in Humans
Eric Levenson - National Institutes of Health - Bethesda, MD - USA
Full Transcriptome Analysis of Murine Norovirus Infection Delineates the Complete Host Response
Daisuke Sano - Hokkaido University - Sapporo - Japan
Diversity of Histo-blood Group Antigen-positive Bacteria as a Specific Adsorbent for Human Noroviruses

Final Scientific Program of the 6th International Calicivirus Conference - Oct 9-13, 2016

Sep 30, 2016

Jessica Plante - University of North Carolina - Chapel Hill, NC - USA
Application of Antigenic Cartography to the Study of Noroviruses
Stefan Taube - Universität Lübeck - Lübeck - Germany
Human and Murine Noroviruses can bind Sialylated and Fucosylated Carbohydrates
Preeti Chhabra - Centers for Disease Control and Prevention - Atlanta, GA - USA
Involvement of interferon β in innate immune activation during tulane virus infection
Daniel Kelly - University of Liverpool - Liverpool - UK
Enrichment as an alternative to PCR in Next-Generation sequencing of noroviruses from clinical samples
session 4Glycans and novel approaches to study caliciviruses
Moderators: Christiane Wobus, Ian Goodfellow
10:15 - 10:45 AM

State of the Art 2: Tim Nice - Oregon Health & Science University - Portland, OR - USA

10:45 - 11:15 AMInterferon-stimulated Innate Immunity to Persistent Norovirus Infection- coffee/ tea breaksession 5 Molecular Epidemiology and Evolution

11:15 - 11:45 AM
11:45 - 12:30 PM

12:30 - 1:45 PM
1:45 - 2:45 PM

2:45 - 3:15 PM
3:15 - 4:45 PM

Moderators: Javier Buesa, Marion Koopmans

State of the Art: Tomoichiro Oka - National Institute of Infectious Diseases - Tokyo - Japan
Molecular Epidemiology of Human Sapoviruses
Katia Koelle - Duke University - Durham, NC - USA
Is Short-term Prediction of Norovirus GII.4 Evolution Possible?
Koo Nagasawa - National Institute of Infectious Diseases - Tokyo - Japan
Molecular Evolution of the Capsid Gene of Human Norovirus Genogroup I Viruses
Gabriel Parra - Food and Drug Administration - Silver Spring, MD - USA
Static and Evolving Norovirus Genotypes: Implications for Epidemiology and Immunity- lunch
session 5 Molecular Epidemiology and Evolution
Moderators: Javier Buesa, Marion Koopmans
Martin Chan - The Chinese University of Hong Kong - Hong Kong - China
Molecular Epidemiology of Norovirus GII.17 Kawasaki, Hong Kong, China, 2014—2016
Peter White - University of New South Wales - Sydney - Australia
Noroviruses and Emerging Agents of Gastroenteritis
Filemon Bucardo - National Autonomous University of Nicaragua - León - Nicaragua
Pediatric Norovirus GII.4 infections over 16 years in Nicaragua
Mustafizur Rahman - International Centre for Diarrhoeal Disease Research, Bangladesh - Dhaka - Bangladesh
Novel Norovirus Recombinants and Tentative New Genotypes in Hospital Settings in Bangladesh
session 6Burden of Disease
Moderators: Christine Moe, Gabriel Parra

State of the Art: Aron Hall - Centers for Disease Control and Prevention - Atlanta, GA - USA
The Global Burden of Norovirus Disease
Daniel Olson - Children's Hospital Colorado - Aurora, CO - USA
Rapid active Seroprevalence Surveys as a tool to Measure Norovirus Disease Burden in Resource-limited Settings
Benjamin Lopman - Emory University, Atlanta, GA - USA

Final Scientific Program of the 6th International Calicivirus Conference - Oct 9-13, 2016

4:45 - 6:15 PM
6:00 - 6:30 PM

Sep 30, 2016

The Burden of Norovirus in Latin America
Nicole Van Abel - USEPA - Washington, DC - USA
Estimate Health Risk from Drinking and Recreational Water Exposure to Noroviruses in Sewage-polluted Surface Water in South Africa
Joseph Bonifacio - Research Institute for Tropical Medicine - Muntinlupa City - Philippines
Etiology of Non-rotavirus Gastroenteritis Pathogens among Hospitalized Children < 5 years of age in the Philippines, 2015
Frank Sandmann - London School of Hygiene & Tropical Medicine - London - UK
Estimating Impact of Norovirus Outbreaks on Hospital bed availability using Seasonal Bed Closures for Acute Gastroenteritis as Proxy
Thomas Verstraeten - P95 - Leuven - Belgium
Medically Attended Norovirus Disease In England: Estimates From 2007-2013 Using The CPRD
Day 2 poster view with cheese and wine- remove posters Day 2

Wednesday October 12
7:15 - 8:15 AM

Continental breakfast
session 7 Epidemiology

8:00 - 8:30 AM
8:30 - 10:00 AM

10:00 - 10:30 AM
10:30 - 12:00 PM

Moderators: Na Liu, Peter White

State of the Art: Peter Teunis - RIVM - Bilthoven, the Netherlands
Who Infected Whom: a Network View on Norovirus Transmission
Bonita Lee - University of Alberta - Edmonton, Canada
Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE) - Enhanced Gastroenteritis Surveillance from Patient to Laboratory
Na Liu - Institute for Viral Disease Control and Prevention, China CDC - Beijing, China
Human Calicivirus prevalence among Children under 5 years of age Hospitalized for Diarrhea in China, 2009-2014
Zufan Sisay Worku - Addis Ababa University - Addis Ababa - Ethiopia
Prevalence and Molecular Characterization of Human Noroviruses and Sapoviruses in Ethiopia
Sandra Niendorf - Robert Koch-Institut - Berlin - Germany
Molecular Characterization of Sapovirus Infections between 2007 and 2015 in Germany
Marta Diez-Valcarce - Centers for Disease Control and Prevention - Atlanta, GA - USAPrevalence and Genotype Distribution of Sapovirus in Children in Nashville, Tennessee, USA
Tulio Fumian - Oswaldo Cruz Foundation - Rio de Janeiro - Brazil
One year of Norovirus Activity in Brazil and Identification of the Novel Kawasaki 2014 GII.17, May 2015 to 2016
- coffee/ tea breaksession 7 Epidemiology
Moderators: Na Liu, Peter White
Molly Steele - Emory University - Atlanta, GA - USA
Population-wide Impact of Vaccinating Food Workers for Norovirus: a Transmission Modeling Study
Katy Gaythorpe - University of Cambridge - Cambridge - UK
What is the Basic Reproduction Ratio of Norovirus?
Ingeborg Boxman - Food and Consumer Product Safety Authority - Wageningen - the Netherlands
Evaluation of Environmental Sampling for Food-borne Norovirus Outbreaks in the Netherlands, 2006-2015
Nicola Page - National Institute for Communicable Diseases - Johannesburg - South Africa

Final Scientific Program of the 6th International Calicivirus Conference - Oct 9-13, 2016

12:00 - 1:15 PM
1:15 - 1:45 PM
1:45 - 3:15 PM

3:15 - 3:45 PM
3:45 - 5:15 PM

6:00 PMSep 30, 2016

Caliciviruses in HIV-infected Children in South Africa between 2009 and 2013
Amy Kirby - Emory University - Atlanta, GA - USA
Norovirus Seroprevalence in NHANES Specimens From the United States in 1999-2000 and 2003-2004
Jan Vinjé - Centers for Disease Control and Prevention - Atlanta, GA - USA
Does Recombination Extends the Life-span of GII.4 variants?
- lunchsession 8Caliciviruses in Non-Human Hosts
Moderators: Veronica Costantini, Vito MartellaState of the Art: Linda Saif - The Ohio State University - Wooster, OH - USA
Animal Caliciviruses: Pathogenesis and Host Factors
Jacques Lependu - University of Nantes - Nantes - France
Proposal for a Unified Classification System and Nomenclature of Lagoviruses
Jackie Mahar - University of Sydney - Sydney - Australia
Benign Rabbit Caliciviruses Exhibit Evolutionary Dynamics Similar to their Virulent Relatives
Leila Nicholson - Landcare Research - Lincoln -New ZealandCharacterization of a Non-Pathogenic New Zealand Rabbit Calicivirus
Jacob Kocher - University of North Carolina - Chapel Hill, NC - USA
Sequence Identification and Virus-like particle Synthesis of a Novel species of Norovirus: Bat Norovirus
Yaoska Reyes - National Autonomous University of León - León - Nicaragua
Calicivirus in Pigs and Cows from Rural Nicaragua
Miranda de Graaf - Erasmus Medical Center - Rotterdam - the Netherlands
Norovirus infections in Harbor Porpoises
session 9Foodsafety and Environmental Distribution

Moderators: Leena Maunula, Daisuke Sano

State of the Art: Glória Sanchez - University of Valencia - Valencia - Spain
Norovirus in Food: Current Trends and Future Challenges
Steven Duret - Food and Drug Administration - College Park, MD - USA
Modeling the Impact of Intervention Strategies and ill Food Employee behavior on the Risk associated with Norovirus in Retail Food
Qiuhong Wang - The Ohio State University - Wooster, OH - USA
Comparison of Binding of GII.4 and GI.1 Human Norovirus to Lettuce
David Kingsley - United States Department of Agriculture - Dover, DE - USA
Resilience of Human Norovirus as Judged by the PGM-MB assay
Soizick Le Guyader - Ifremer - Nantes - France
Comparing Tulane and Norwalk viruses in Oysters: Tissue Distribution and PersistenceDavid Nieuwenhuijse - Erasmus Medical Center - Rotterdam - the Netherlands
Fecal-oral Route Pathogen Surveillance using Shotgun Metagenomics
Takayuki Miura - Tohoku University - Sendai - Japan
Sewage Sample Analysis using Pyrosequencing: Temporal Change in Norovirus Genotypes circulating in Miyagi, Japan, 2013-2016
Meet at Hyatt lobby for transport to Conference DinnerFinal Scientific Program of the 6th International Calicivirus Conference - Oct 9-13, 2016

Sep 30, 2016

Thursday October 13
7:45 - 8:45 AM

Continental breakfast
session 10

8:30 - 9:00 AM

Control and Prevention

Moderators: Ralph Baric, Joana Rocha-Pereira

State of the Art: Robert Atmar - Baylor College of Medicine - Houston, TX - USA

Norovirus Vaccines: Current Status and Future Prospects
Kim Leesun - VaxArt - San Francisco, CA - USA
Oral Immunization of a Norovirus Vaccine leads to Superior Intestinal IgA Responses in Animals
Shaohua Lei - Virginia Tech - Blacksburg, VA - USA
Protective Efficacy of Probiotics and Rice Bran in Gnotobiotic Pig Challenge Model of Human Norovirus
Lisa Lindesmith - University of North Carolina - Chapel Hill, NC - USA
Impact of Pre-Exposure History and Host Genetics on Norovirus Vaccine Responses
Sasirekha Ramani - Baylor College of Medicine - Houston , TX - USA
Antibody Secreting Cell and Memory B Cell Immune Responses to Intramuscular Administration of a Bivalent Human Norovirus Vaccine
10:00 - 10:15 AM General Discussion - Status and Future of Norovirus Vaccines
10:15 - 10:45 AM - coffee/ tea break
10:45 - 11:45 PM session 10Control and Prevention
Moderators: Ralph Baric, Joana Rocha-Pereira
10:45 - 11:00 PM Karla Passalacqua - University of Michigan - Ann Arbor, MI - USA
Blocking Deubiquitinases inhibits MNV-1 replication via changes in Host Cell Metabolism and Oxidative Status
11:00 - 11:15 AM Natalie Netzler - University of New South Wales - Sydney - Australia
Broad-Spectrum Non-Nucleoside Polymerase Inhibitors for Caliciviruses
11:15 - 11:30 AM Jana van Dycke - University of Leuven - Leuven - Belgium
Inhibition of Norovirus and Rotavirus Replication by One Small Molecule Polymerase Inhibitor
11:30 - 11:45 AM Ladislau Kovari - Wayne State University - Detroit, MI - USA
Design and Development of Protease Inhibitors for Norovirus Infection
11:45 AM - NOON - Closing session: Jan Vinjé
9:00 - 10:00 AM