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2015; Zhang et al. 2015, Ĭĭ 2017)8dQ siRNA ^ RNA ŔüŅ DNA §¯íɏRNA
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2015)82- ìƗ\AGmđE]×ǩưƻBkŹ9[ RNA ɂǂ]ķŊ§y¦CŠkBY[TW>m8 °°ɂǂ]ķŊ\ȱJW^, ǖǹȯĔĄĕX=m eIF2α ]®²ȥíiɂǂǼĦ²}Ȉ TIA-1 ]ƦƛCȦǰX=mHYCƯknW>QɏKedersha et al.

1999ɐ8ȒıX^đE] RNA ɂǂĩĆ²}ȈC, Ƙĝ]ƼÊŸȗ^œQ[>C7IDR(intrinsically disordered regions)ȣãi LCɏlow complexityɐȣãYĀ_nmƘĝ]s¥ȥſĊ\jmǑlȓJȣãpœS7²}Ȉ—²}ȈȰƫ½ËƟ\ÖEHYC
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@knW>mɏBanani et al. 2017ɐ8ŶƗ\A>W^ TIA-1 ¡¨±~X=mYInm UBP1CûĝIn,°ɂǂb]ĩĆCƱǻInW>mɏSorenson & Bailey-Serres 2014ɐ8JBJ[Ck, O]Ǻǆ[áĕ§y¦iO]Á] RNA ɂǂǼĦĄĕ\U>W^cYqZƯǲC[>8 ŶƗ\A>Wh, RNA ɂǂķŊ§y¦]ĊŪòƜ^ÙȖL\mƔCđ>YǗ@knmC, O]µşXŶƗƚƘ[ƦƞiƝĎŃƾ§y¦\AGm RNA ɂǂ]ÖD
i, O]ŸŊĄĕ^ŶƗƚƘX=mùǜŅhɌ>8Î@_, ŶƗ] mRNA i microRNA^ǆǛȰpƷìLmHYX, ǆǛȰ¥ª´¬²]ĊƨY[l, Ʀƞ³ǈǐáí
pŘ@W>m8dQŶƗÊØÊXhǁƿpȖKQ microRNA, siRNA, mRNA [Z]ȏȕ
CƱǻInW>mɏMolnar et al. 2010, ȧƠ÷ 2017ɐ8Hnk RNA ]ǆǛȰƷǩ^, ǆǛȰXǆǛȈpǏFŶƗƘŦ]ŸȗX=m­¨¤´pÀJWǩonW>mYǗ@knW>m8JBJ[Ck, O]§y¦\ȱJW^¸Š[ƔCđEſInW>m8µş, ìƗX^ microRNA Cw{u´/w²u´\jTWá  % "    ( & !#  '#)$#*      ƈħǛX=mw{´¦\ÏĖJWȏȕInmHYCƯknWAlɏMittelbrunn &Sanchez-Madrid 2012ɐ, ŶƗ\A>Wh microRNA, siRNA, mRNA [ZC­¨¤´]e[kM, w{´¦ÏĖƧ\ȏȕInmùǜŅhǗ@knm8ƛĆ, ŶƗǆǛÛX^, RNA ɂǂCȮȊȽȏȕInmČú^s}²ǎǌÏĖƧ\ǩon, ǆǛǪīX^Ŀħƿ¶\ÐƤInmHYCƯknW>mɏHamada et al. 2012, Steffens et al.
2014ɐ8ǆǛȰ] RNA ȏȕ\ȱJWh, Ǻǆ[ RNA ɂǂu§´²~pĊƨYJQưƻ\jl, ţ[mƯǲCĽknmHYCŧĻInm8 dQƝĎŃƾ\A>Wh, ƚƘ[æľCĖĆLmùǜŅC=m8Ǣÿƌ>HY\ȖİƞǙūÄX=m 22℃XƞǙINQ±uX^, P-body ]ŸŊĄĕX=mdecapping Ȥǅ]ƊŅºŀX=m DCP2 ]ĒðCǆǛȈ\ĖĆJW>Q8ǆǛȈ\ŒśJW>Q DCP2 C, ɌƏūÄ\ABnmY DCP1 XźȃJQ P-body \ȼƺLmHYCƱǻIn, ɌƏūÄƘƥƧ\ P-body \AGm decapping ƊŅCɌdTW>mùǜŅCƳĂ
InW>mɏMotomura et al. 2015ɐ8RNA ɂǂ^, ƞÊǞXǱonWAkM, ǆǛȈ\ĖĆLm RNA-²}Ȉ]ɂǂX=m8O]Qgƥ[m RNA ɂǂCȺŕJWŕǶLm
RGX, RNA ]öGƎJCXDmùǜŅC=m8Î@_, ûKɌƏūÄXǼĦInm
°ɂǂ^, P-body \ȺŕJWĩĆLmHYCƯknWAl,°ɂǂÛXǖǹōæInQ RNA ^, ƙƇ\ŃKW, RNA áǵ\ȕknW>mùǜŅCǗ@knm8H]j?[ RNA ɂǂȰX] RNA ]ilõl[Z^ìƗXh¸Š[ƔCđE, ¿ļ]ǾɃX=m8%"1 ŶƗ\A>W:RNA ɂǂưƻ;YȩŌTQưƻ^HndXĨ[E, ɍŠŧX=mYǷ@m8JBJ[Ck RNA ɂǂưƻ]ĊƲY[TQøÚƧ[Ğɋ]đE^, Ğ^ŶƗXǩonWDQ8Î@_,°ɂǂ^:ƝĎďí\ģŃLmQg\v{´²~ȞÆĕ]ǖǹpōæJ, ŞQ[ƝĎ\ȜŃLmQg]²}ȈpƦƛINm;ĸép
ŐTW>mYInW>mC, H]Ğɋ^¤ĉɇǆǛXǩonW>mɏNover et al.
1989ɐ8Ĺk^ 25℃Y 40℃]¤ĉɇǆǛ]Ø²}Ȉ±ru¯ô`, ƞíĘƧ\ǃǮJQ°ɂǂƢáɏHeat shock granulesɐBkŏßJQ mRNA pƟ>W invitro ǖǹINQ²}Ȉ±ru¯pƃȎǵŮJ, ǊȀpĽW>m8
 ìƗ]ƵǉǆǛɂǂɏneuronal granulesɐ, ƞƀǆǛɂǂɏgerm cell granulesɐ[Z^ǖǹōæInQƙŉXǆǛÛpș_n, O]=YȜâ[Čŋ³u¥²~XǖǹCȯĔ
InmHYCƯknW>m8H]j?[ mRNA ]ȏȕ^ 1930 ıÃ\ǩonQĮĒñǆ  % "    ( & !#  '#)$#*      ǛǨɅX=my®ɏɒǆǛXťĒ 10 cmɐpƟ>QĞɋXƦǲInWAl, Ċȡ\=mųBkÕCķŊInm¶ȡdXŇċÆțƗȈɏmRNAɐCȕknmHYCƳĂInW>Q(Haemmerling 1963)8ƛĆ, ¨¯ŶƗYJWÍonm±upýfȶ¶ŶƗX^, Ʀƞæľ\ȱomj?[ǖǹōæɂǂ]ĖĆǟÊ^ǲUBTW>[>C,ɅÇJQ§y¦CĖĆLmùǜŅ^Ɍ>Yńonm8 RNA ɂǂ^, ŶƗ]Ʀƞiǈǐáí, ƝĎŃƾ[ZpŘ@m RNA ÃȂ]ĊƨX=l,ůQJW>mĸé^ĒD>8¿ļ, :RNA ɂǂ;Y>?Ÿȗ\ƉƩJQưƻCŪŵíLmHYX, Ik[mŶƗƶĘưƻ]ƦĪYƌíCŧĻInm8/0Ūưƻ^ JSPS ƶưȇ JP16H01229, JP15H04628 ]ëŊpöGQh]XL8

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