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Category:German musical groups Category:Musical groups established in 2006 Category:Musical groups from BerlinThe effectiveness of different doses of subcutaneous rituximab in comparison to the intravenous route in diffuse large B-cell lymphoma: the INDERCO study. Subcutaneous rituximab has been reported as an effective and feasible treatment option for patients with rheumatoid
arthritis and other autoimmune diseases. We performed a study to evaluate whether subcutaneous rituximab is an alternative to intravenous rituximab in patients with diffuse large B-cell lymphoma (DLBCL) and to compare this route with standard intravenous rituximab. We conducted a prospective single-arm multicenter study to determine the effectiveness and safety of weekly subcutaneous
rituximab at two dose levels (500 mg/m2 and 1000 mg/m2) in patients with DLBCL. We included 42 patients; 15 received 500 mg/m2 of subcutaneous rituximab, and 27 received 1000 mg/m2. Subcutaneous rituximab was well tolerated and no serious adverse events were reported. Overall, complete response rate was 26% (95% CI, 12.7-43.3), partial response rate was 59% (95% CI, 43.6-72.3),
and stable disease rate was 15% (95% CI, 6.1-28.4) at 3 months, which did not differ significantly between the 500-mg/m2 and 1000-mg/m2 groups. The median progression-free survival (PFS) was 6 months (95% CI, 2.5-10.5) in all patients. The median PFS was significantly longer in the 1000-mg/m2 group (7.5 months, 95% CI, 4.7-10.3) than the 500-mg/m2 group (5.5 months, 95% CI,1.6-9.4, P =.003). At a median follow-up of 13 months, median overall survival time was 14 months (95% CI, 6.8-21.2) in all patients. Subcutaneous rituximab at two dose levels (500 mg/m2 and 1000 mg/m2) was well tolerated in patients with DLBCL and resulted in a longer PFS than standard intravenous ritux 2d92ce491b

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