Hiroshi Naka
Research Center for Materials Science, Nagoya University
Chikusa, Nagoya 464-8602, Japan
E-mail: h_naka@nagoya-u.jp
Web: http://noy.chem.nagoya-u.ac.jp/H_Naka-E/
Current appointments
Assistant Professor at Research Center for Materials Science, Nagoya University
Research interests
Solving problems related to organic/organometallic chemistry and catalysis. In particular, (1)Homogeneous/heterogeneous catalysis using simple substances (H2, H2O and CO2) for selective
organic synthesis. (2) Photocatalytic conversion of alcohols for fine chemical synthesis. (3)Chemical biology based on transition metal complexes.
Employment
2008–present

2006–2008

Assistant Professor
Research Center for Materials Sciences, Nagoya University(with Profs. Ryoji Noyori and Susumu Saito)
Research Associate
Graduate School of Pharmaceutical Sciences, Tohoku University(with Prof. Yoshinori Kondo)

External appointments
2012–present
Visiting Research Fellow Tokyo University of Science
2008–2010
Visiting Research Fellow Hokuriku University
2006–present
Visiting Research Fellow RIKEN
Education
2008
Ph.D. in Chemistry, Nagoya University(Profs. Masanobu Uchiyama and Shigehiro Yamaguchi)
2005
Visiting Student at Vrije Universiteit Amsterdam, Netherlands (Prof. Koop Lammertsma)
2005
M.S. in Pharmaceutical Sciences and Clinical Pharmacy, the University of Tokyo
2003
B.S. in Pharmaceutical Sciences, the University of Tokyo
Membership
The Chemical Society of Japan; The Pharmaceutical Society of Japan; The American Chemical
Society; The Society of Synthetic Organic Chemistry; Catalysis Society of Japan; Kinka Chemical
Society; Institute for Quantum Chemical Exploration; The Noyori Forum
Personal
Gender: Male; Nationality: Japanese; Date/place of birth: Born June 1, 1980 / Tokyo.
Married, a father of a son.

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Awards and Honors
2020
Incentive Award of Synthetic Organic Chemistry, Japan 2019FY
2018
Toyota Riken Scholar
2015
Asian Core Program/Advanced Research Network Lectureship Award (Singapore)2014
Chemical Society of Japan Presentation Award
2005
JSPS Research Fellowship for Young Scientists (DC1)
Grants1. Grant-in-Aid for Scientific Research (B), MEXT, Japan"Transfer (De)hydration for Organic Synthesis"
Hiroshi Naka (PI, Nagoya Univ.)
2020–2024, 13,900,000 JPY.
2. Toyota Riken Scholar Project, Phase 2"TBA"
Hiroshi Naka (PI, Nagoya Univ.)
2020–2021, 400,000 JPY.
3. Naohiko Fukuoka Memorial Foundation"TBA"
Hiroshi Naka (PI, Nagoya Univ.)
2020–2021, 1,400,000 JPY.
4. Toyota Riken Scholar Project, Phase 1"TBA"
Hiroshi Naka (PI, Nagoya Univ.)
2019–2020, 300,000 JPY.
5. AIST–Nagoya University Joint Funding"Development of Flow Reactor for Heterogeneous Photocatalysis"
Hiroshi Naka (PI, Nagoya Univ.)
2019–2020, 400,000 JPY.
6. Iwatani Foundation"TBA"
Hiroshi Naka (PI, Nagoya Univ.)
2019−2020, 2,000,000 JPY.
7. AIST–Nagoya University Joint Funding"Development of Flow Reactor for Heterogeneous Photocatalysis"
Hiroshi Naka (PI, Nagoya Univ.)
2018–2019, 800,000 JPY.
8. Integrated Research on Chemical Synthesis, MEXT, Japan"Organometallic Probes for Sulfated Sugars"
Hiroshi Naka (PI, Nagoya Univ.), Takato Hara (CI, Toho Univ.)
2018–2019, 500,000 JPY.
9. Toyota Riken Scholar Project"Transfer Hydration and Dehydration of Organic Compounds"
Hiroshi Naka (PI, Nagoya Univ.)
2018–2019, 1,000,000 JPY.
10. Grant-in-Aid for Scientific Research (C), MEXT, Japan

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11.

12.

13.

14.

15.

16.

17.

18.

19.

20.

"Selective Transfer (De)hydration"
Hiroshi Naka (PI, Nagoya Univ.)
2017–2020, 3,700,000 JPY.
Grant from JGC Scholarship Foundation, MEXT, Japan"Conversion of Alcohols by Semiconductor Photocatalysts for Organic Synthesis"
Hiroshi Naka (PI, Nagoya Univ.)
2017–2018, 2,000,000 JPY.
Integrated Research on Chemical Synthesis, MEXT, Japan"Control of Photocatalysis by Precise Surface Modification of Heterogeneous Photocatalysts"
Hiroshi Naka (PI, Nagoya Univ.), Mitushiro Arisawa (CI, Osaka Univ.), Andrew E. H.
Wheatley (CI, Univ. Cambridge)
2017–2018, 500,000 JPY.
Grant-in-Aid for Scientific Research (C), (Generative Research Fields) MEXT, Japan"Transition State Design for Inventing Hydration Catalysts"
Hiroshi Naka (PI, Nagoya Univ.)
2015–2019, 3,600,000 JPY.
Grant from TOBE MAKI Scholarship Foundation“Catalytic Conversion of Aliphatic Alcohols for Organic Synthesis”
Hiroshi Naka (PI, Nagoya Univ.)
2015–2016, 1,000,000 JPY.
Integrated Research on Chemical Synthesis, MEXT, Japan"Rapid Conversion of Hydrophobic Esters"
Hiroshi Naka (PI, Nagoya Univ.), Tomomi Koshiyama (CI, Kyushu Univ.)
2015–2016, 500,000 JPY.
International Exchanges Scheme (inc RIA and MOST), The Royal Society, UK"New Chitin-supported Nanocatalyts for Selective Arene Hydrogenation"
Andrew E. H. Wheatley (PI, Univ. of Cambridge), Hiroshi Naka (Co-PI, Nagoya Univ.)
2015–2016, 6000.00 GBP (ca. 1,100,000 JPY in 2015).
Grant-in-Aid for Scientific Research (C), MEXT, Japan"Photocatalytic Transformation of Alcohols for Selective Organic Synthesis"
Hiroshi Naka (PI, Nagoya Univ.)
2014–2018, 3,900,000 JPY.
Grant from Ichihara International Scholarship Foundation“Structure and Function of Polysaccharide-supported Ruthenium Catalysts”
Hiroshi Naka (PI, Nagoya Univ.)
2014–2015, 500,000 JPY.
Noyori Forum Joint Project"Photocatalysts for Using Alcohols as Carbon Resources"
Ryoji Noyori (PI, Nagoya Univ.), Susumu Saito (Co-PI, Nagoya Univ.), Hiroshi Naka (Co-PI,
Nagoya Univ.)
2013–2014, 24,000,000 JPY (Funds from 5 chemical companies).
Integrated Research on Chemical Synthesis, MEXT, Japan"Highly Chemoselective Nitrile Hydration"
Hiroshi Naka (PI, Nagoya Univ.), Ken-ichi Shimizu (CI, Hokkaido Univ.)
2013–2014, 500,000 JPY.

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21. Grant from Yoshida Foundation for Science and Technology"Cobalt-catalyzed Markovnikov Functionalization of Terminal Alkynes"
Hiroshi Naka (PI, Nagoya Univ.)
2012–2013, 250,000 JPY (Travel Grant).
22. Integrated Research on Chemical Synthesis, MEXT, Japan"Reaction Mechanism on Cobalt-catalyzed Hydration of Alkynes"
Hiroshi Naka (PI, Nagoya Univ.), Takashi Kamachi (CI, Kyusyu Univ.)
2012–2013, 500,000 JPY.
23. Grant-in-Aid for Young Scientists (B), MEXT, Japan"Porphyrin-based Molecular Catalysts for Hydration Reactions"
Hiroshi Naka (PI, Nagoya Univ.)
2011–2013, 3,600,000 JPY.
24. Integrated Research on Chemical Synthesis, MEXT, Japan (w/ Hokkaido Univ.)"Solid-supported Catalysts for Nitrile Hydration"
Hiroshi Naka (PI, Nagoya Univ.), Ken-ichi Shimizu (Hokkaido Univ. CI)
2011–2012, 1,000,000 JPY.
25. Noyori Forum Joint Project"Basic Research on Transformation of Carbon Dioxide"
Susumu Saito (PI, Nagoya Univ.), Ryoji Noyori (Co-PI, Nagoya Univ.), Hiroshi Naka (Co-PI,
Nagoya Univ.)
2010–2011, 24,000,000 JPY (Funds from 7 chemical companies).
26. Noyori Forum Joint Project"Design and Application of Multi-functional Molecular Catalyst"
Susumu Saito (PI, Nagoya Univ.), Ryoji Noyori (Co-PI, Nagoya Univ.), Hiroshi Naka (Co-PI,
Nagoya Univ.)
2008–2010, 48,000,000 JPY (Funds from 8 chemical companies).
27. Nagoya University Science Foundation"Robust Catalysts with New Molecular Mechanisms"
Hiroshi Naka (PI, Nagoya Univ.)
2008–2009, 328,000 JPY (Competitive start-up funding from Nagoya University).
28. Grant-in-Aid for Young Scientists (B), MEXT, Japan"Origin of Selectivity in Ate-complexes-mediated Construction of Aromatic Compounds"
Hiroshi Naka (PI, Tohoku Univ.)
2007–2008, 3,640,000 JPY.
29. Tohoku University G-COE Grant for Young Scientists"Construction of Higher-order Organic Materials Using Chemoselective Bases"
Hiroshi Naka (PI, Tohoku Univ.)
2007–2008, 2,000,000 JPY.
30. Grant from Tohoku Kaihatsu Foundation"Structure and Function of Phosphazene–Metal Complexes"
Hiroshi Naka (PI, Tohoku Univ.)
2007–2008, 220,000 JPY (Travel Grant).

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International Invited Lectures
2019
Department Seminar, Nanjing University of Science and Technology, China.
2019Core-to-Core and GTR Symposium, Nagoya University, Japan.
2019
Chemistry Department Seminar, Dalhousie University, Canada.
2019
McGill Chemical Society Seminar, McGill University, Canada.
2019
Chemistry Department Seminar, Queen’s University, Canada.
2019Special Department Seminar, University of Ottawa, Canada.
2019Special Chemistry Seminar, University of Toronto, Canada.
2019
Department Seminar, University of Alberta, Canada.
2019
Organic Seminar, University of British Colombia, Canada.
2017
ACP Lectureship Award Seminar, National University of Singapore, Singapore.
2017
ACP Lectureship Award Seminar, Nanyang Technological University, Singapore.
2015
Intergroup Seminar at the Laboratory of Organic Chemistry, ETH Zurich, Switzerland.
2011
11th IRTG Joint Symposium, University of Muenster, Muenster, Germany.
2010
Pacifichem2010 (Early Main Group Chemistry), Honolulu, Hawaii, USA.
2010
The 4th International G-COE Chem6 Symposium for Emergence of New Molecular
Chemistry, Tokyo Institute of Technology, Japan.
2010
International Research Training Group "Complex Functional Systems in Chemistry"
Muenster (GER) - Nagoya (JPN) Lectureship, University of Muenster, Muenster
Germany.
Domestic Invited Lectures
2020
2020FY Synthetic Organic Chemistry Seminar, Hiroshima (Provisional).
2019
2019FY Second Workshop on Powder Design and Process for Energy Problems, Gifu.
2019
Trial Lecture, Nagoya Koyo Senior Highschool, Nagoya.
2019
Kyoto Univ. Human & Environmental Studies Seminar, Kyoto University, Kyoto.
2019
Nagoya Univ. GTR Retreat Meeting, Suzuka.
2018
Kyoto Univ. Human & Environmental Studies Winter Seminar, Kyoto University, Kyoto.
2018
Interdisciplinary Seminar, Toho University, Chiba.
2018
The First Conference on Deuterium Materials, Nagoya Institute of Technology, Nagoya.
2018
Special Lecture on Molecular Transformation, Tohoku University, Sendai.
2017
JPIJS Lecture, Shizuoka University, Hamamatsu.
2016
Conference on Molecular Catalysts in Next Generation, Institute of Molecular Science,
Okazaki.
2016
IQCE Lecture, The University of Tokyo, Tokyo.
2014
Special Lecture of Pharmaceutical Society of Japan, Tokai Region, Aichi Gakuin
University, Nagoya.
2010
Hokuriku University Academic Frontier Annual Meeting FY2009, Hokuriku University,
Kanazawa.
2010
Hokuriku University Academic Frontier Special Lecture, Hokuriku University,
Kanazawa.
2009
Special Lecture of Pharmaceutical Society of Japan, Tokai Region, Aichi Gakuin
University, Nagoya.
2008
Tohoku University G-COE Lecture, Tohoku University, Sendai.

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Teaching in English
2017
2014–present
2010

Studium Generale (all undergraduate), Nagoya U.
School of Science, Chemistry Laboratory (3rd year undergraduate), Nagoya U.
IRTG Seminar (graduates), Muenster U.

Teaching in Japanese
2014–present
School of Science, Chemistry Exercise (4th year undergraduate), Nagoya U.
2008–present
School of Science, Chemistry Laboratory (3rd year undergraduate), Nagoya U.
2006–2008
School of Pharmaceutical, Laboratory Works (3rd year undergraduate),
Tohoku U.
Consulting/Outreach
2017
Aichi Science Festival Lecture (to public citizens)2015
The Chemical Society of Japan Chemistry Grand Prix (managing member)2009–present
The Noyori Forum (core academic member)2011 (Aug 1–3)
The Noyori Laboratory Presents Luncheon Forum (organizer and lecturer;
event for high school students) Highlighted in the Chunichi Newspaper (Aug. 2,2011), Official Activity of International Year of Chemistry 2011 (IUPAC)

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Selected List of Publications with Brief Descriptions
1.

Catalytic Transfer Hydration of Cyanohydrins to alpha-Hydroxyamides
T. Kanda, A. Naraoka, *H. Naka
J. Am. Chem. Soc. 141, 825−830 (2019).
Hydration of cyanohydrins to α-hydroxycarboxamides is one of the most important reactions insynthetic chemistry. However, hydration of cyanohydrins is not always straightforward. This paper
describes the palladium(II)-catalyzed transfer hydration of cyanohydrins to α-hydroxyamides by using
carboxamides as water donors. This method enables selective hydration of various cyanohydrins toafford α-hydroxyamides under mild conditions.

2.

N-Alkylation of Functionalized Amines with Alcohols Using a Copper-Gold Mixed Photocatalytic
SystemL.-M. Wang, Y. Morioka, K. Jenkinson, *A.E.H. Wheatley, *S. Saito, *H. Naka
Sci. Rep. 8, 6931 (2018).
A mixed heterogeneous photocatalytic system of Cu/TiO2 and Au/TiO2 was developed for N-alkylationof amines with alcohols. This method allowed the first, practical photocatalytic synthesis of variously
functionalized amines, as well as selective monoalkylation and non-symmetrical dialkylation.

3.

Hydration of Nitriles to Amides by a Chitin-supported Ruthenium Catalyst
A. Matsuoka, T. Isogawa, Y. Morioka, B. R. Knappett, *A. E. H. Wheatley, *S. Saito, *H. Naka
RSC Adv. 5, 12152–12160 (2015).
A robust method for hydration of nitriles was developed by using chitin-supported ruthenium catalyst.
Chitin proved to be the best as a support for Ru nanoparticles.

4.

Hydration of Terminal Alkynes Catalyzed by Water-Soluble Cobalt Porphyrin Complexes.
T. Tachinami, T. Nishimura, R. Ushimaru, R. Noyori, *H. Naka
J. Am. Chem. Soc. 135, 50−53 (2013).
The first cobalt(III)-catalyzed alkyne hydration was discovered. This method allowed highly
chemoselective hydration of variously functionalized alkynes and opened a new field of CoIII catalysis.

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List of Full Publications
Original Papers
1.

Transfer Hydration of Dinitriles to Diamides
Asuka Naraoka, *Hiroshi Naka
Synlett 30, 1977–1980 (2019). (DOI: 10.1055/s-0039-1690026) (Invited Cluster)2.

Acceptor-Controlled Transfer Dehydration of Amides to Nitriles
Hiroyuki Okabe, Asuka Naraoka, Takahiro Isogawa, Shunsuke Oishi, *Hiroshi Naka
Org. Lett. 21, 4767–4770 (2019). (DOI: 10.1021/acs.orglett.9b01657)

3.

Catalytic Transfer Hydration of Cyanohydrins to alpha-Hydroxyamides
Tomoya Kanda, Asuka Naraoka, *Hiroshi Naka
J. Am. Chem. Soc. 141, 825−830 (2019). (Highlighted in Org. Process Res. Dev. 23, 114−121 (2019).)

4.

Pd-Catalyzed β-Selective C–H Arylation of Thiophenes with Triarylantimony Difluorides
Yuki Kitamura, Yuki Murata, Ayaka Oguri, Mio Matsumura, Naoki Kakusawa, *Hiroshi Naka, *Shuji
Yasuike
Asian J. Org. Chem. 8, 138−143 (2019).

5.

Pd/TiO2-Photocatalyzed Self-Condensation of Primary Amines to Afford Secondary Amines at Ambient
Temperature
Lyu-Ming Wang, Kensuke Kobayashi, Mitsuhiro Arisawa, *Susumu Saito, *Hiroshi Naka
Org. Lett. 21, 341−344 (2019). (Highlighted in Front Cover.)6.

Photocatalytic N-Methylation of Amines over Pd/TiO2 for the Functionalization of Heterocycles andPharmaceutical Intermediates
Lyu-Ming Wang, Kellie Jenkinson, Andrew E. H. Wheatley, Keiko Kuwata, Susumu Saito, *Hiroshi
Naka
ACS Sustainable Chem. Eng. 6, 15419–15424 (2018).

7.

Copper(II) Bis(Diethyldithiocarbamate) Induces the Expression of Syndecan-4, a Transmembrane
Heparan Sulfate Proteoglycan, via P38 MAPK Activation in Vascular Endothelial Cells
Takato Hara, Hiroko Tatsuishi, Tomomi Banno, Tomoya Fujie, Chika Yamamoto, Hiroshi Naka,*Toshiyuki KajiInt. J. Mol. Sci. 19, 3302 (2018).

8.

N-Alkylation of Functionalized Amines with Alcohols Using a Copper-Gold Mixed Photocatalytic
System
Lyu-Ming Wang, Yuna Morioka, Kellie Jenkinson, *Andrew E. H. Wheatley, *Susumu Saito, *Hiroshi
Naka
Sci. Rep. 8, 6931 (2018).

9.

Photocatalytic Hydrogenolysis of Allylic Alcohols for Rapid Access to Platform Chemicals and Fine
Chemicals
Yuki Takada, Joaquim Caner, Hiroshi Naka, *Susumu Saito
Pure Appl. Chem. 90, 167–174 (2018). (invited conference paper)

10.

A Fluorinated Cobalt(III) Porphyrin Complex for Hydroalkoxylation of Alkynes
Richiro Ushimaru, Takuho Nishimura, Toshiki Iwatsuki, *Hiroshi Naka
Chem. Pharm. Bull. 65, 1000–1003 (2017).

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11.

Photocatalytic Transfer Hydrogenolysis of Allylic Alcohols on Pd/TiO2: A Shortcut to(S)-(+)-Lavandulol
Yuki Takada, Joaquim Caner, Kaliyamoorthy Selvam, Hiroshi Naka, *Susumu Saito
Chem. Eur. J. 23, 18025–18032 (2017).

12.

Copper Diethyldithiocarbamate as an Inhibitor of Tissue Plasminogen Activator Synthesis in Cultured
Human Coronary Endothelial Cells
Tomoya Fujie, Shiori Okino, Eiko Yoshida, Chika Yamamoto, *Hiroshi Naka, *Toshiyuki Kaji
J. Toxicol. Sci.42, 553–558 (2017).

13.

A Versatile Synthesis of Triarylantimony Difluorides by Fluorination of Triarylstibanes with Nitrosyl
Tetrafluoroborate and Their Antitumor Activity
Yuki Kitamura, Mio Matsumura, Yuki Murata, Mizuki Yamada, Naoki Kakusawa, Motohiro Tanaka,
Hiroyuki Okabe, *Hiroshi Naka, *Tohru Obata, *Shuji Yasuike
J. Fluorine Chem. 199, 1–6 (2017).

14.

Dehydrogenation of Primary Aliphatic Alcohols by Au/TiO2 Photocatalysts
Masaki Shibata, Ryoko Nagata, Susumu Saito, *Hiroshi Naka
Chem. Lett. 46, 580–582 (2017).

15.

Selective Hydrogenation of Arenes to Cyclohexanes in Water Catalyzed by Chitin-Supported Ruthenium
Nanoparticles
Yuna Morioka, Aki Matsuoka, Kellie Binder, Benjamin R. Knappett, *Andrew E. H. Wheatley, *Hiroshi
Naka
Catal. Sci. Technol. 6, 5801–5805 (2016).

16.

Copper Diethyldithiocarbamate as an Activator of Nrf2 in Cultured Vascular Endothelial Cells
Tomoya Fujie, Masaki Murakami, Eiko Yoshida, Tadashi Tachinami, Yasuhiro Shinkai, Yasuyuki
Fujiwara, Chika Yamamoto, Yoshito Kumagai, *Hiroshi Naka, *Toshiyuki Kaji
J. Biol. Inorg. Chem. 21, 263–273 (2016).

17.

Induction of Metallothionein Isoforms by Copper Diethyldithiocarbamate in Cultured VascularEndothelial Cells
Tomoya Fujie, Yukino Segawa, Tomoki Kimura, Yasuyuki Fujiwara, Chika Yamamoto, Masahiko Satoh,*Hiroshi Naka, *Toshiyuki Kaji
J. Toxicol. Sci. 41, 225–232 (2016).

18.

Zinc Diethyldithiocarbamate as an Inducer of Metallothionein in Cultured Vascular Endothelial Cells
Tomoya Fujie, Yukino Segawa, Akane Uehara, Takehiro Nakamura, Tomoki Kimura, Eiko Yoshida,
Chika Yamamoto, Masanobu Uchiyama, *Hiroshi Naka, *Toshiyuki Kaji
J. Toxicol. Sci. 41, 217–224 (2016).

19.

N-Methylation of Amines with Methanol at Room Temperature
Vasily N. Tsarev, Yuna Morioka, Joaquim Caner, Qing Wang, Richiro Ushimaru, Akihiko Kudo, Hiroshi
Naka, *Susumu Saito
Org. Lett. 17, 2530–2533 (2015).

20.

Hydration of Nitriles to Amides by a Chitin-supported Ruthenium Catalyst
Aki Matsuoka, Takahiro Isogawa, Yuna Morioka, Benjamin R. Knappett, *Andrew E. H. Wheatley,*Susumu Saito, *Hiroshi Naka
RSC Adv. 5, 12152–12160 (2015).

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21.

Why p-Cymene? Conformational Effect in Asymmetric Hydrogenation of Aromatic Ketones with a
η6-Arene/Ruthenium(II) Catalyst
Aki Matsuoka, Christian A. Sandoval, Masanobu Uchiyama, Ryoji Noyori, *Hiroshi Naka
Chem. Asian J. 10, 112–115 (2015).

22.

Synthesis of Propylene from Renewable Allyl Alcohol by Photocatalytic Transfer Hydrogenolysis
Joaquim Caner, Zijun Liu, Yuki Takada, Akihiko Kudo, Hiroshi Naka, *Susumu Saito
Catal. Sci. Technol. 4, 4093–4098 (2014).

23.

Activation of Cellular Defense Mechanism by Organic-Inorganic Hybrid Molecules
Tomoya Fujie, Hiroshi Naka, Chika Yamamoto, Yasuhiro Shinkai, Yoshito Kumagai, *Toshiyuki Kaji
Yakugaku Zasshi 134, 813−815 (2014).

24.

Redox-Selective Generation of Aldehydes and H2 from Alcohols under Visible Light
Zijun Liu, Joaquim Caner, Akihiko Kudo, Hiroshi Naka, *Susumu Saito
Chem. Eur. J. 19, 9452−9456 (2013). (Highlighted in Synfacts 9, 1138 (2013).)

25.

Hydration of Terminal Alkynes Catalyzed by Water-Soluble Cobalt Porphyrin Complexes
Tadashi Tachinami, Takuho Nishimura, Richiro Ushimaru, Ryoji Noyori, *Hiroshi Naka
J. Am. Chem. Soc. 135, 50−53 (2013).

26.

Acetals of N,N-Dimethylformamides: Ambiphilic Behavior in Converting Carbon Dioxide to Dialkyl
Carbonates
Yuki Takada, Aki Matsuoka, Ya Du, Hiroshi Naka, *Susumu Saito
Chem. Lett. 42, 146–147 (2013).

27.

Bis(L-cysteinato)zincate(II) as a Coordination Compound that Specifically Induces Metallothionein
Gene Transcription Without Inducing Cell-stress-related Gene Transcript*Tomoki Kimura, Kengo Yoshida, Chika Yamamoto, Minako Suzuki, Tomoko Uno, Masakazu Isobe,
Hiroshi Naka, Shuji Yasuike, Masahiko Satoh, Toshiyuki Kaji, *Masanobu Uchiyama
J. Inorg. Biochem. 117, 140−146 (2012).

28.

One-Pot Nitrile Aldolization/Hydration Operation Giving β-Hydroxy Carboxamides
Akihiro Goto, Hiroshi Naka, Ryoji Noyori, *Susumu Saito
Chem. Asian J. 6, 1740–1743 (2011).

29.

Generation of Arylzinc Reagents Through an Iodine–zinc Exchange Reaction Promoted by a
Non-metallic Organic Superbase*Hiroshi Naka, Keisuke Ito, Masahiro Ueno, Koji Kobayashi, *Yoshinori Kondo
New J. Chem. 34, 1700–1706 (2010).

30.

Chiral eta6-Arene/N-Tosylethylenediamine–Ruthenium(II) Complexes: Solution Behavior and Catalytic
Activity for Asymmetric Hydrogenation*Christian A. Sandoval, Fusheng Bie, Aki Matsuoka, Yoshiki Yamaguchi, Hiroshi Naka, Yuehui Li,
Koichi Kato, Noriyuki Utsumi, Kunihiko Tsutsumi, Takeshi Ohkuma, Kunihiko Murata, *Ryoji Noyori
Chem. Asian J. 5, 806–816 (2010).

31.

SN2´ Reaction of Organozinc Reagents Activated by Catalytic tBu-P4 Base in the Presence of LiCl
Koji Kobayashi, Masahiro Ueno, Hiroshi Naka, *Yoshinori Kondo
Chem. Eur. J. 15, 9805–9809 (2009).

32.

A Mixed Alkyl-amido Aluminate as a Kinetically Controlled Base*Hiroshi Naka, James V. Morey, Joanna Haywood, Dana Eisler, Mary McPartlin, Felipe García,

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Hironaga Kudo, Yoshinori Kondo, *Masanobu Uchiyama, *Andrew E. H. Wheatley
J. Am. Chem. Soc. 130, 16193–16200 (2008).
33.

Catalytic Deprotonative Functionalization of Propargyl Silyl Ethers with Imines*Hiroshi Naka, Daiki Koseki, *Yoshinori Kondo
Adv. Synth. Catal. 350, 1901–1906 (2008).

34.

Chiral Bisphosphazides as Dual Basic Enantioselective Catalysts*Hiroshi Naka, Nobuhiko Kanase, Masahiro Ueno, *Yoshinori Kondo
Chem. Eur. J. 14, 5267–5274 (2008).

35.

Organozinc Reagents in DMSO Solvent: Remarkable Promotion of SN2' Reaction for Allene Synthesis
Koji Kobayashi, Hiroshi Naka, Andrew E. H. Wheatley, *Yoshinori Kondo
Org. Lett. 10, 3375–3377 (2008).

36.

Activation of Organozinc Reagents with t-Bu-P4 Base for Transition Metal-free Catalytic SN2' Reaction
Koji Kobayashi, Hiroshi Naka, Andrew E. H. Wheatley, *Yoshinori Kondo
Chem. Commun. 3780–3782 (2008).

37.

Suppressing the Anionic Fries Rearrangement of Aryl Dialkylcarbamates; the Isolation of a Crystalline
ortho-Deprotonated Carbamate
Felipe García, Mary McPartlin, James V. Morey, Daisuke Nobuto, Yoshinori Kondo, Hiroshi Naka,*Masanobu Uchiyama, *Andrew E. H. WheatleyEur. J. Org. Chem. 644–647 (2008).

38.

Solid-phase Synthesis of Phthalocyanine and Tetraazaporphyrin Triangular Prisms
Atsuya Muranaka, Kengo Yoshida, Yusuke Akagi, Hiroshi Naka, Masanobu Uchiyama Yoshinori Kondo,*Nagao Kobayashi
Tetrahedron Lett. 49, 5084–5086 (2008).

39.

On the Kinetic and Thermodynamic Reactivity of Lithium Di(alkyl)amidozincate Bases in Directed
Ortho Metalation
Yoshinori Kondo, James V. Morey, Jacqueline C. Morgan, Hiroshi Naka, Daisuke Nobuto, Paul R.
Raithby, *Masanobu Uchiyama, *Andrew E. H. Wheatley
J. Am. Chem. Soc. 129, 12734–12738 (2007).

40.

Theoretical Studies on Ortho Oxidation of Phenols with Dioxygen Mediated by Dicopper Complex:
Hints for a Catalyst with the Phenolase Activity of Tyrosinase*Hiroshi Naka, Yoshinori Kondo, Shinya Usui, Yuichi Hashimoto, *Masanobu Uchiyama
Adv. Synth. Catal. 349, 595–600 (2007).

41.

An Aluminum Ate Base: Its Design, Structure, Function and Reaction Mechanism*Hiroshi Naka, *Masanobu Uchiyama, Yotaro Matsumoto, *Andrew E. H. Wheatley, Mary McPartlin,
James V. Morey, Yoshinori Kondo
J. Am. Chem. Soc. 129, 1921–1930 (2007).

42.

Fluorous Synthesis of Yuehchukene by alpha-Lithiation of Perfluoroalkyl-Tagged 1-(Arylsulfonyl)indolewith Mesityllithium
Hiroshi Naka, Yusuke Akagi, Kyoko Yamada, Tatsushi Imahori, Takahiro Kasahara, *Yoshinori Kondo
Eur. J. Org. Chem. 4635–4637 (2007).

43.

Nucleophilic Aromatic Substitution using Et3SiH/cat. t-Bu-P4 as a System for Nucleophile Activation
Masahiro Ueno, Misato Yonemoto, Masahiro Hashimoto, Andrew E. H. Wheatley, Hiroshi Naka,

11

*Yoshinori Kondo
Chem. Commun. 2264–2266 (2007).
44.

Reverse Photochromic Behavior of Iron-Magnesium Complex*Minoru Kobayashi, Akito Takashima, Tomohiko Ishii, Hiroshi Naka, Masanobu Uchiyama, *Kentaro
Yamaguchi
Inorg. Chem. 46, 1039–1041 (2007).

45.

Encapsulation of Hydride by Molecular Main Group Metal Clusters: Manipulating the Source andCoordination Sphere of the Interstitial Ion
Sally R. Boss, Martyn P. Coles, Vicki Eyre-Brook, Felipe García, Robert Haigh, Peter B. Hitchcock,
Mary McPartlin, James V. Morey, Hiroshi Naka, Paul R. Raithby, Hazel A. Sparkes, Christopher W. Tate,*Andrew E. H. WheatleyDalton Trans. 5574–5582 (2006).

46.

Regio- and Chemoselective Direct Generation of Functionalized Aromatic Aluminum Compounds Using
Aluminum Ate Base
*Masanobu Uchiyama, Hiroshi Naka, Yotaro Matsumoto, Tomohiko Ohwada
J. Am. Chem. Soc. 126, 10526–10527 (2004).

Reviews
1.

Recent Advances in Transfer Hydration of Nitriles with Amides or Aldoximes*Hiroshi Naka and Asuka Naraoka
Tetrahedron Lett. 61, 151557 (2020). (DOI: 10.1016/j.tetlet.2019.151557) (Digest Paper)

Books
1.

Converting Carbon Dioxide to Chemical Resources by Using Ambiphilic Nature of Alcohols
Hiroshi Naka, Susumu Saito
In Latest Trends in Direct Utilization of Carbon Dioxide, NTS, pp 103−113 (2013). (in Japanese)2.

Aluminum Halides
Hiroshi Naka, Susumu Saito
In Science of Synthesis Knowledge Updates, K. Ishihara Ed.; Thieme: Stuttgart, Vol.2010/4, Section
7.1.3.18, pp 79−92 (2011).

3.

Aluminum Hydrides
Hiroshi Naka, Susumu Saito
In Science of Synthesis Knowledge Updates, K. Ishihara Ed.; Thieme: Stuttgart, Vol. 2010/4, Section
7.1.2.44, pp 69−77 (2011).

Tutorials
1.

Bio-Organometallics based on Copper Complexes
Hiroshi Naka
Ridai Kagaku Forum, 403, 8–9 (2018). (in Japanese)

2.

Beating Organic Reaction
Hiroshi Naka
Kagaku, 72 (5), 62−63 (2017). (in Japanese)

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3.

Molecular Catalysis and the GRRM Methods
Hiroshi Naka
IQCE-NEWS, 23, 1 (2015). (in Japanese)

4.

New Trends in Molecular Catalysis
Hiroshi Naka
RCMS News, 15, in press (2015).

5.

Connecting Benzene Ring and Fluorine with Catalysis
Hiroshi Naka
Kagaku, 65(3), 62−63 (2010). (in Japanese)

6.

Global COE-RCMS International Conference on Organic Chemistry and the 6th Hirata Yoshimasa
Memorial Lecture
Hiroshi Naka
RCMS News, 11, 10 (2010). (in Japanese)7.

Towards Robust Molecular Catalysis
Hiroshi Naka
RCMS News, 10, 20–21 (2009). (in Japanese)

Patents
1.

METHOD FOR PRODUCING ALKENYL ALUMINUMS
Hiroshi Naka, Shinsuke Iwata, Ryoji Noyori / Nagoya University
JP 2014-45342, 07.03.2014.

2.

METHOD OF PRODUCING TERTIARY AMINES
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Vasily N. Tsarev, Joachim Kanaa Kazademont, Akihiko
Kudo / Nagoya University
JP 2013-213167, 10.10.2013.

3.

METHOD OF PRODUCING ORGANIC COMPOUNDS
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Joachim Kanaa Kazademont, Zijun Liu, Akihiko Kudo /Nagoya University
JP 2013-193470, 18.09.2013.

4.

METHOD OF PRODUCING CYCLIC URETHANE
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Foo Siong Wan / Nagoya University
JP 2013-65083, 26.03.2013; JP2014-189509A, 06.10.2014.

5.

METHOD OF MANUFACTURING CARBONYL COMPOUND
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Zijun Liu, Joachim Kanaa Kazademont, Akihiko Kudo /Nagoya University
JP 2012-181888, 20.08.2012; JP 2014-037396A, 27.02.2014.

6.

FAT CELL DIFFERENTIATION INHIBITOR
Akira Onodera, Masahiko Sato, Naonobu Uchiyama, Tokuo Ito, Hiroshi Naka, Shuji Yasuike / Kobe
Gakuin, Aichi Gakuin
JP2012-107557, 09.05.2012; 2013-234150A, 21.11.2013.

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7.

METHOD FOR PRODUCING ANNULAR URETHANE
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Yusuke, Yamazaki, Yuki Takada / Nagoya University
JP 2012-70113, 26.03.2012; 2013-199456A, 03.10.2013.

8.

METHOD FOR PRODUCING CYCLIC URETHANE
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Yusuke, Yamazaki, Foo Siong Wan / Nagoya University
JP 2012-28845, 13.02.2012; JP2013-163668A, 22.08.2013.

9.

METHOD OF PRODUCING HIGHER AMINE
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Ya Du / Nagoya University
JP 2010-208526, 16.09.2010; JP2012-062281A, 29.03.2012.

10.

METHOD OF PRODUCING CARBONIC ESTER
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Yusuke, Yamazaki, Ya Du / Nagoya University
JP 2010-203712, 10.09.2010; JP2012-056910A, 22.03.2012.

11.

METHOD FOR PRODUCING PYRROLE
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Osamu Kose, Junki Ando / Nagoya University
JP 2010-49823, 05.03.2010; 2011-184338A, 22.09.2211

12.

METHOD FOR PRODUCING DIMER
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Osamu Kose, Junki Ando / Nagoya University
JP 2010-49735, 05.03.2010; JP2011-184336A, 22.09.2011.

13.

METHOD FOR PRODUCING MONOAMINE
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Zhao Yingsheng / Nagoya University
JP 2010-1557, 06.01.2010; JP 2011-140456A, 21.07.2011.

14.

METHOD FOR PRODUCING ALCOHOL AND CATALYST FOR DIMERIZATION REACTION OF
ALCOHOL
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Osamu Kose, Takashi Miura / Nagoya University
JP 2009-299231, 23.12.2009; JP 2011-136970A, 14.07.2011.

15.

PROCESS FOR PRODUCING CARBONATE ESTER
Ryoji Noyori, Susumu Saito, Hiroshi Naka, Kasumi Kakuma, Yusuke, Yamazaki, Ya Du / Nagoya
University
JP 2009-233817, 25.12.2009; JP 2011-098949A, 19.05.2011.

16.

FUNCTIONAL PHOSPHAZIDE HAVING HIGH HEAT STABILITY
Yoshinori Kondo, Hiroshi Naka, Tetsuya Shimo / Tohoku University
JP 2008-193767, 28.07.2008; JP 2010-30941A, 12.02.2010.

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