第 2 日目

12 月 2 日（木）第2日目12月2日（木）2AS-01Room 01 (Pacifico Yokohama Conference Center, 1F, Main Hall)

9:00-11:15【E】

Frontiers in Sleep and Hibernation Research
Organizer：Masashi Yanagisawa（University of Tsukuba）

2AS-01-Introduction
Masashi Yanagisawa（University of Tsukuba）

2AS-01-1

【9:00】【9:02】

Analyses of the mechanism and function of REM sleep

Yu Hayashi1,2（1Grad. Sch. of Med., Kyoto Univ., 2WPI-IIIS, Univ. of Tsukuba）

2AS-01-2

【9:28】

Toward the molecular basis for "sleepiness."

Masashi Yanagisawa（WPI-IIIS, Univ. of Tsukuba）

2AS-01-3

【9:54】

Systems Biology of Mammalian Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep

Hiroki R. Ueda1,2（1Systems Pharmacology, Graduate School of Medicine, , 2 Laboratory for Synthetic Biology, Center for Biosystems
Dynamics Research）

2AS-01-4

【10:20】A mammalian hibernator Syrian hamster exhibits hepatic cold resistance with the aid of superior ability in retaining vitamin E
Yoshifumi Yamaguchi（HIB., Insti. Low. Temp. Sci., Hokkaido Univ.）

2AS-01-5

【10:46】

Hypothalamic neuronal system that induces regulated hypometabolic stateTakeshi Sakurai（University of Tsukuba）

2AS-01-Conclusion
Masashi Yanagisawa（University of Tsukuba）【11:12】

2AS-02

Room 02 (Pacifico Yokohama Conference Center, 3F, 301)
9:00-11:15【E】
Co-hosted by: Grant-in-Aid for Scientific Research on Innovative Areas "New frontier for ubiquitin biology driven by chemotechnologies"
Breakthroughs in the ubiquitin research accelerated by chemo-technologies
Organizers：Yasushi Saeki（Tokyo Metropolitan Institute of Medical Science）
Mikihiko Naito（The University of Tokyo）

2AS-02-Introduction
Yasushi Saeki（Tokyo Metropolitan Institute of Medical Science）

2AS-02-1

【9:00】【9:02】

Understanding the ubiquitin-proteasome system by advanced proteomics

Yasushi Saeki, Hikaru Tsuchiya, Takuya Tomita, Akinori Endo（Prot. Metab. Project, TMiMS）

2AS-02-2

【9:18】

Molecular mechanism and physiological function of Quality Control to recognize and eliminate aberrant translation
Toshifumi Inada（Institute of Medical Science, The University of Tokyo）

2AS-02-3

【9:34】

Regulation of inflammation and ubiquitin esterification by the RBR ubiquitin ligase HOIL-1L

Carlos Gomez Diaz2, Alan Rodriguez Carvajal2, Mayu Seida1, Akiko Okumura1, Fumiyo Ikeda1,2（1Medical Institute of Bioregulation,
Kyushu University, 2IMBA）

2AS-02-4

【9:50】

Ubiquitin-chemotechnology powered by organic chemistry and molecular evolution
Gosuke Hayashi（Dept. of Biomol. Eng., Grad. Sch. of Eng., Nagoya Univ.）

2AS-02-5

【10:06】

A targeted protein knockdown by using the power of plants

Masato Kanemaki1,2（1Nat. Ins. Genet. , 2Dep. Genet., SOKENDAI）

The 44th Annual Meeting of the Molecular Biology Society of Japan7

第 2 日目

2AS-02-6

12 月 2 日（木）【10:22】

Branched ubiquitin chains promote chemically-induced targeted protein degradation

2 1
Fumiaki Ohtake1,2, Ai Kaiho-Soma1, Yoshino Akizuki（Institute for Advanced Life Sciences, Hoshi University, 2School of Pharmacy
and Pharmaceutical Sciences, Hoshi University）

2AS-02-7

【10:38】

Molecular mechanisms of cereblon-based drugs

Takumi Ito, Tomoko Asatsuma-Okumura, Hiroshi Handa（Dept. of Chem. Biol., Tokyo Med. Univ.）

2AS-02-8

【10:54】Development of Highly Selective Anti-Cancer Drugs by Targeted Protein Degradation.
Mikihiko Naito（Dept. of TPD., Grad. Sch. of Pharm. Sci., Univ. of Tokyo）

2AS-02-Discussion
2AS-03【11:10】
9:00-11:15【E】

Room 03 (Pacifico Yokohama Conference Center, 3F, 302)

Epigenetic botanical garden-towards next stage
Organizers：Yuichiro Watanabe（The University of Tokyo）
Reina Komiya（Okinawa Institute of Science and Technology Graduate University）

2AS-03-Introduction

【9:00】Yuichiro Watanabe（The University of Tokyo）

2AS-03-1

【9:03】

Investigating the molecular basis of spontaneous epiallele formation in plants
Robert Schmitz（University of Georgia）

2AS-03-2

【9:38】

Epigenetic regulation of intragenic transposons and gene transcription in plant genomesHidetoshi Saze（Plant Epigenetics Unit, OIST）

2AS-03-3【9:53】

Plastic plant sex, orchestrated by epigenetic fluctuation
Takashi Akagi（Okayama University）

2AS-03-4

【10:08】Pervasive non-coding transcription by Pol V suggesting a genome surveillance mechanism
Masayuki Tsuzuki1,2（1Grad. Sch. of Arts Sci., Univ. of Tokyo, 2MCDB, Univ. of Michigan）

2AS-03-5

【10:23】RNA silencing in male organ development

1 1
Reina Komiya1,2, Hinako Tamotsu1, Koji Koizumi3, Saori Araki（OIST., STG, 2PRESTO., JST, 3OIST., SIS）

2AS-03-6

【10:38】Landscape of Transcription Termination in Arabidopsis Revealed by Single-molecule Nascent RNA Sequencing
Jixian Zhai（School of Life Sciences, Southern University of Science and Technology, Shenzhen, China）

2AS-03-Conclusion
Reina Komiya（Okinawa Institute of Science and Technology Graduate University）

2AS-04

Room 04 (Pacifico Yokohama Conference Center, 3F, 303)
Supported by: Grant-in-Aid for Transformative Research Areas (B) Parametric Translation【11:13】
9:00-11:15【E】

Parametric Biology Based on Translation Rate Control
Organizers：Masao Doi（Kyoto University）
Yoshie Harada（Osaka University）

2AS-04-Introduction
Masao Doi（Kyoto University）

2AS-04-1

【9:00】【9:03】

Gravity activates mitochondrial translation through cell adhesion-FAK axis

Shintaro Iwasaki1,2（1RIKEN Cluster for Pioneering Research, 2Department of Computational Biology and Medical Sciences, Graduate
School of Frontier Sciences, The University of Tokyo）

8

第 44 回日本分子生物学会年会

第 2 日目

12 月 2 日（木）2AS-04-2

【9:21】

Dissecting gene regulatory networks with CiBER-Seq

Ryan Muller, Zuriah A Meacham, Lucas Ferguson, Nicholas Ingolia（Dept of Molecular and Cell Biology, Univ of California, Berkeley）

2AS-04-3

【9:51】

Ribosome dynamics captured by deep sequencing and deep learningLiana Lareau（Univ of California, Berkeley）

2AS-04-4

【10:21】

Parametric entrainment of the circadian clock via altering translational velocity

Takaihito Miyake, Yuichi Inoue, Masao Doi（Dept. of Syst. Biol., Grad. Sch. of Pharm. Sci., Kyoto Univ.）

2AS-04-5

【10:39】Intracellular thermal signaling regulates translation

Beini Shi1, Naoko Kamiya1, Takashi Funatsu1, Kohki Okabe1,2（1Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 2PRESTO, JST）

2AS-04-6

【10:57】

Organoids-on-a-chip models for understanding neuronal circuits and underlying protein synthesis regulations
Yoshiho Ikeuchi1,2（1IIS, Univ. Tokyo, 2Inst. AI and Beyond, Univ. Tokyo）

2AS-05

Room 05 (Pacifico Yokohama Conference Center, 3F, 304)
Co-hosted by: Japanese Vascular Biology and Medicine Organization

9:00-11:15【E】

Vascular Network System as a Frontline in Biological Defense
Organizers：Tetsuro Watabe（Tokyo Medical and Dental University）
Masayuki Yoshida（Tokyo Medical and Dental University）

2AS-05-Introduction

【9:00】

Masayuki Yoshida（Tokyo Medical and Dental University）

2AS-05-1

【9:03】The Down syndrome-related gene sets regulate vascular inflammation via a cytokine stormTakashi Minami（Div. of Mol.Vasc.Biol. IRDA, Kumamoto Univ.）

2AS-05-2

【9:25】Development of novel therapeutic strategies for intractable vascular diseases via regulation of inflammatory signaling
Yoshikazu Nakaoka（Nat. Cereb. and Cardiovasc Ctr. RI. Dept. of Vasc. Physiol.）

2AS-05-3

【9:47】

Vaccine development from infections diseases to common diseases
Hironori Nakagami（Grad.Sch. of Med, Osaka Univ.）

2AS-05-4

【10:09】Disruption of Endothelial TGF-ß/BMP signal balance impairs vascular Homeostasis
Fumiko Itoh（Tokyo Univ. Pharm. Life Sci.）

2AS-05-5

【10:31】

Roles of signaling and transcriptional networks during maintenance of vascular systems
Tetsuro Watabe（Dept. Biochem., Grad. Sch. Med. Dent., Tokyo Med. & Dent. Univ.）

2AS-05-6

【10:53】

Vascular integrity by resident endothelial stem cell population

Nobuyuki Takakura（Dept. of Signal Transduction, RIMD, Osaka Univ.）

2AS-16

Room 16 (Pacifico Yokohama Conference Center, 5F, 502)

9:00-11:15【E】

Fetomaternal interactions in development
Organizers：Toshihiko Fujimori（National Institute for Basic Biology）
Guojun Sheng（Kumamoto University）

2AS-16-Introduction
Guojun Sheng（Kumamoto University）

2AS-16-1

【9:00】【9:05】

Cooperative interaction between two retrovirus-derived genes, Peg10 and Peg11/Rtl1, in the feto-materal interface ofplacenta

3 1
Fumitoshi Ishino1, Hirosuke Shiura2, Takashi Kohda2, Tomoko Kaneko-Ishino（Res. Inst., Tokyo Med. Dent. Univ. (TMDU), 2Fac. of
3Life Environ. Sci., Yamanashi Univ., Sch. of Med., Tokai Univ.）

The 44th Annual Meeting of the Molecular Biology Society of Japan

9

第 2 日目

12 月 2 日（木）2AS-16-2

【9:30】

Epithelial-Mesenchymal Transition mediates mesothelial fusion during chorioallantoic membrane formation
Hiroki Nagai, Guojun Sheng（IRCMS, Kumamoto University）

2AS-16-3

【9:55】

Intrauterine pressures cushioned by Reichert's membrane are crucial for early mouse morphogenesis
Isao Matsuo, Chiharu Kimura-Yoshida, Yoko Ueda（Reserch Inst., Osaka W & C Hospital）

2AS-16-4

【10:20】Morphological changes of the uterine luminal epithelium during mouse implantation
Toshihiko Fujimori（Div. of Embryology, NIBB）

2AS-16-5

【10:45】

Deciphering the mechanisms of how primates are formed

Hongmei Wang1,2,3,4（1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences,
2
University of Chinese Academy of Sciences, 3Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 4Beijing
Institute for Stem Cell and Regenerative Medicine）

2AS-16-Conclusion

【11:10】Toshihiko Fujimori（National Institute for Basic Biology）

2AS-17

Room 17 (Pacifico Yokohama Conference Center, 5F, 503)

9:00-11:15【E】

Phagocytic Transdifferentiation: A Novel Insight into Evolution and Cell Diversity
Organizers：Sho Morioka（Gifu University）
Kumiko Tsukui（National Institute of Infectious Diseases）

2AS-17-Introduction

【9:00】Sho Morioka（Gifu University）

2AS-17-1

【9:03】

Chimeric efferocytosis receptor promotes efferocytosis and alleviates inflammatory disorders

Yusuke Yamaoka1,2, Shinji Tanaka 1, Brady Barron3, Mark D. Okusa 1, Kodi S. Ravichandran3, Sho Morioka1,4（1Dept. of Med., Sch. ofMed., Univ. of Virginia, 2Dept. of PID., Grad. Sch of Med., Gifu University, 3Dept. of MIC., Sch. of Med., Univ. of Virginia, 4Domain ofIntegrated Life Systems, Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University）

2AS-17-2

【9:23】

Specialized pro-resolving mediators in atherosclerosis and efferocytosis
Gabrielle Fredman（Dept of Mol. and Cell Phy, Albany Medical College）

2AS-17-3

【9:43】

Molecular mechanisms of trogocytosis in unicellular eukaryotes

Kumiko Nakada-Tsukui1, Kumiko Shibata1,2, Natsuki Watanabe2, Satoki Itsuji2, Yuka Uesugi2, Misato Shimoyama2,
2 1
Tomoyoshi Nozaki（
Dept. of Parasitol., Natl. Inst. Infect. Dis., 2Dept. of Biomed. Chem., Grad. Sch. of Med., Univ. of Tokyo）

2AS-17-4

【9:53】

Diversity and evolution of the phagocytosing eubacterium Candidatus Uab amorphumTakashi Shiratori（University of Tsukuba）

2AS-17-5

【10:13】

The role of erythrophagocytosis by microglia in brain development

Ryuta Koyama（Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. of Tokyo）

2AS-17-6

【10:33】Basophils gain the capacity of antigen presentation via trogocytosis-mediated transfer of peptide-MHC class II complexes
from DCs
Kensuke Miyake, Hajime Karasuyama（Advanced Research Institute, Tokyo Med. Dent. Univ.）

2AS-17-7

【10:53】

PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma
2 1
Ai Kotani1, Masaharu Kawashima（Adv. Med. Sci. Tokai Univ, Sch. of Med., 2Dept. Oncol and Hematol. Jikei Med, Univ. ）2AS-17-Conclusion
Sho Morioka（Gifu University）

10【11:13】

第 44 回日本分子生物学会年会

第 2 日目

2PS-16

Room 16 (Pacifico Yokohama Conference Center, 5F, 502)

12 月 2 日（木）15:45-18:00【E】

Molecular bases of membrane remodeling and organization
Organizers：Shiro Suetsugu（Nara Institute of Science and Technology）
Tetsuya Takeda（Okayama University）

2PS-16-1

【15:45】Extracellular vesicles by filopodia, Filopodium-Derived Vesicles, by the I-BAR domain proteins

Shiro Suetsugu, Takuya Oyama, Hooi Ting Hu, Toshifumi Fujioka, Tamako Nishimura（Div. Biol. Sci., Grad. Sch. of Sci. Tech., Nara
Inst. Sci. Tech. (NAIST)）

2PS-16-2

【16:02】

Theoretical model of cell spreading and migration dynamics driven by curved nucleators of actin

1 1
Nir Gov1, Samo Penic2, Ales Iglic2, Rajkumar Sadhu1, Yoav Ravid（Department of Chemical and Biological Physics, Weizmann
2Institute, Rehovot, Israel, Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana）2PS-16-3

【16:25】

Mechanisms underlying the oncogenic signal-mediated exosome upregulation

Chitose Oneyama1,2,3（1Div. of Can. Cell Reg., Aichi Can. Ctr., 2Dep. of Targ. and Drug Disc., Grad. Sch. of Med., Nagoya Univ., 3Dep. ofOncol., Grad. Sch. of Pharm. Sci., Nagoya City Univ.）

2PS-16-4

【16:43】Mechanisms for biogenesis and release of apical and basolateral exosomes from epithelial cells
Mitsunori Fukuda（Lab. of Membr. Trafficking Mech., Grad. Sch. of Life Sci., Tohoku Univ.）

2PS-16-5

【17:01】

Intracellular membrane remodeling in Flavivirus infected cells

Eiji Morita（Dept. of Biochem.& Mol. Biol., Agri & Life Sci., Hirosaki Univ. ）2PS-16-6

【17:19】Reconstitution approaches to elucidate pathogenesis of congenital myopathy caused by defective membrane remodeling
Tetsuya Takeda（Grad. Sch. of Med. Dent. Pharma. Sci., Okayama Univ.）

2PS-16-7

【17:37】Aggregation-Dependent Endocytosis
Harvey McMahon（MRC-LMB）

2PS-17

Room 17 (Pacifico Yokohama Conference Center, 5F, 503)

15:45-18:00【E】

Technology, genomics, computational biology approach towards ncRNA functions
Organizer：Piero Carninci（RIKEN）

2PS-17-Introduction

【15:45】

Piero Carninci（RIKEN）

2PS-17-1

【15:50】

Structural and chemical modification requirements for SINEUP, antisense RNA that enhance translation

1 1
Naoko Toki1, Harshita Sharma1, Matthew Valentine1, Stefano Gustincich2, Hazuki Takahashi1, Piero Carninci（RIKEN Center for2
Integrative Medical Sciences, Istituto Italiano di Tecnologia）

2PS-17-2

【16:15】Biological dynamics mediated by RNA modification and epitranscriptomics

Tsutomu Suzuki（Dept. of Chem. & Biotech., Grad. Sch. of Eng., Univ. of Tokyo）2PS-17-3

【16:40】Nanopore direct RNA Sequencing as a new paradigm for studying RNA modifications
Tommaso Leonardi（Italian Institute of Technology）

2PS-17-4

【17:05】RNA circles with minimized immunogenicity as potent PKR inhibitors

Chu-Xiao Liu1, Si-Kun Guo1, Fang Nan2, Yi-Feng Xu1, Li Yang2,3, Ling-Ling Chen1,3,4（1State Key Laboratory of Molecular Biology,
Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute ofBiochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 2CAS Key Laboratory ofComputational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese
Academy of Sciences, Chinese Academy of Sciences, 3School of Life Science and Technology, ShanghaiTech University, 4School of Life
Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences）

The 44th Annual Meeting of the Molecular Biology Society of Japan

11

第 2 日目

12 月 2 日（木）2PS-17-5

【17:30】SINEUPs: a new functional class of natural and synthetic antisense, long non-coding RNAs that activate translation.

Stefano Gustincich1, Stefano Espinoza1, Carlotta Bon1, Paola Valentini1, Sabrina D'Agostino1, Bianca PIerattini1,2, Abraham Matey2,Massimiliano Volpe1, Gloria Ros3, Francesca Persichetti3, Hazuki Takahashi4,5, Diego Cotella3, Remo Sanges2, Piero Carninci4,5,
3 1
Claudio Santoro（Istituto Italiano di Tecnologia, 2Area of Neuroscience, SISSA, 3Dipartimento di Scienze della Salute, Universita'delPiemonte Orientale, 4Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, 5Functional Genomics
Laboratory, Graduate School of Medical Life Science, Yokohama City University）

2PS-17-Conclusion

【17:55】

Piero Carninci（RIKEN）

12

第 44 回日本分子生物学会年会