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Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 23.03.2023*Version number 2

Revision: 23.03.2023

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Trade name: HFC-134a
Article number: DF134a change
EC number:
212-377-0
Registration number: 01-2119459374-33-0003
1.2 Relevant identified uses of the substance or mixture and uses advised against:
Sector of Use SU8 Manufacture of bulk, large scale chemicals (including petroleum products)
1.3 Details of the supplier of the safety data sheet
Manufacturer/Supplier:
DAIKIN INDUSTRIES, LTD. CHEMICALS DIVISION:OSAKA UMEDA TWIN TOWERS SOUTH, 1-13-1 Umeda, Kita-ku, Osaka-shi, Osaka, 530-0001, Japan
Phone:+81-6-6147-9702 Fax:+81-6-6147-9807
Further information obtainable from: http://www.daikin.com/
1.4 Emergency telephone number:
Japan: +81-6-6349-7521
China: +86-532-8388-9090, +86-21-34151689
South Korea: +82-2-568-1722
Americas: CHEMTREC +1-800-424-9300 (Outside US/Canada: +1-703-527-3887)
Europe: +49-211-179 225-0

SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008

Press. Gas (Liq.) H280 Contains gas under pressure; may explode if heated.
2.2 Label elements
Labelling according to Regulation (EC) No 1272/2008:
The substance is classified and labelled according to the CLP regulation.
Signal word: Warning
Precautionary statements:
P410+P403 Protect from sunlight. Store in a well-ventilated place.
*SECTION 3: Composition/information on ingredients
Information on ingredients:
CAS: 811-97-2 1,1,1,2-TetrafluoroethanePress. Gas (Liq.), H280
Identification number(s)EC number: 212-377-0*99.9%SECTION 4: First aid measures
4.1 Description of first aid measures
General information: Seek immediate medical advice.
After inhalation:
Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult a doctor if symptoms persist.
In case of unconsciousness place patient stably in side position for transportation.
In case of emergency to rescue the victims; be sure to wear supplied-air respirator (SAR) or self-contained breathing
apapratus (SCBA).
If the patient does not breathe or hardly breathes, unbutton clothes, secure the airway for breathing and perform
artificial respiration.
At high levels, cardiac arrhythmia may occur.
(Contd. on page 2)

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Safety data sheet
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Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: HFC-134a(Contd. of page 1)

After skin contact:
In cases of frost bites, rinse with plenty of water. Do not remove clothing.
Immediately rinse with warm water and soap.
Consult a doctor in case of complaints.
After eye contact:
Rinse opened eye for several minutes under running water.
Consult an ophthalmologist in case of complaints.
After swallowing: Not applicable.
Information for doctor:
Catecholamines such as adrenaline, and other compounds having similar effects, should be reserved for emergencies
and then used only with special caution.
The examining physician should advise workers taking medications containing catecholamines that they may be atincreased risk and should avoid excessive exposure.
4.2 Most important symptoms and effects, both acute and chronic:
Frost bitesHigh concentrations cause asphyxiation. May cause an abnormal heart rhythm and prove suddenly fatal.
4.3 Indication of any immediate medical attention and special treatment needed:
No further relevant information available.

SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing agents: Use fire extinguishing methods suitable for surrounding conditions.
5.2 Special hazards arising from the substance or mixture:
Formation of toxic gases is possible during heating or in case of fire.
Receptacle may explode when heated.
5.3 Advice for firefighters:
Move receptacle to a safe place immediately if possible. If not, spray water on the receptacles and surrounding
equipment to cool.
If receptacle catches fire: cool them with plenty of water.
If possible, close valves of receptacles to shut off the gas supply.
Protective equipment:
Wear self-contained breathing apparatus and protective suit.
Do not inhale explosion gases or combustion gases.

SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures:
Wear appropriate protective devices (See Section 8 Exposure Controls/Personal Protection).
Avoid contact with eyes and skin.
Do not inhale the product.
Ensure adequate ventilation before entering the area.
Stay on the windward side.
Keep out unauthorized persons.
6.2 Environmental precautions:
Suppress gases/fumes/haze with water spray.
Inform authorities in case of gas release.
Must not be emitted into the environment.
6.3 Methods and material for containment and cleaning up: Ensure adequate ventilation.
6.4 Reference to other sections:
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
*SECTION 7: Handling and storage
7.1 Precautions for safe handling:
Ensure good ventilation/exhaustion at the workplace.
Handle with care. Avoid jolting, friction and impact.
For heating receptacle, use hot compresses or lukewarm water below 40
Do not use heaters.

.
(Contd. on page 3)

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Safety data sheet
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Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: HFC-134a(Contd. of page 2)

Stay on the windward side when working outdoors.
Be careful of leakage when attaching/detaching receptacles.
Inhaling large quantities may cause cardiac arrhythmia or asphyxiation or both.
Keep away from naked flame or metal heated over 300 - 400
to prevent thermal decomposition that may form
toxic gases.
Do not handle until all safety precautions have been read and understood.
Information about fire - and explosion protection:
The product is not flammable.
Keep ignition sources away - Do not smoke.
Keep respiratory protective device available.
7.2 Conditions for safe storage, including any incompatibilities:
Storage
Requirements to be met by storerooms and receptacles:
Store only in unopened original receptacles.
Store in a cool and dry location.
Keep containers tightly sealed.
Information about storage in one common storage facility:
See section 10 for information on incompatible materials.
Further information about storage conditions:Protect from humidity and water.
Protect from heat and direct sunlight.
Store containers in a well ventilated area.
Store locked up.
7.3 Specific end use(s): No further relevant information available.

SECTION 8: Exposure controls/personal protection
8.1 Control parameters No further information available.
Ingredients with limit values that require monitoring at the workplace:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
AIHA WEEL-TWA 1000ppm
DNELs:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
Inhalative DNEL - worker 13936 mg/m³ (long-term exposure) (systemic effects)
DNEL - consumer 2476 mg/m³ (long-term exposure) (systemic effects)
PNECs:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
PNEC 0.1 mg/l (fresh water)
1 mg/l (intermittent release)0.01 mg/l (marine water)
73 mg/l (sewage treatment plant)
PNEC 0.75 mg/kg dw (fresh water sediment)
8.2 Exposure controlsAppropriate engineering controls No further data; see item 7.
Individual protection measures, such as personal protective equipment
General protective and hygienic measures:
Wash hands before breaks and at the end of work.
Do not eat or drink while working.
Keep away from tobacco products.
Respiratory protection: Use respiratory protective device with organic gas cartridge.
(Contd. on page 4)56.0

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Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: HFC-134a(Contd. of page 3)

Hand protection
Protective gloves
To avoid skin problems reduce the wearing of gloves to the required minimum.
Material of gloves:
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality andvaries from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance ofthe glove material can not be calculated in advance and has therefore to be checked prior to the application.
Leather
Eye/face protection
Safety glasses
Body protection: Protective work clothing*SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
General Information
Liquefied gas
Physical state
Colourless
Colour:Ether-likeOdour:Not determined.
Odour threshold:-101 °C
Melting point/freezing point:
Boiling point or initial boiling point and boiling range -26 °C
No data.
Flammability
Lower and upper explosion limit
Product does not present an explosion hazard.
Lower explosive limit:
Product does not present an explosion hazard.
Upper explosive limit:
nonflammable
Flash point:>300-400 °C
Decomposition temperature:
7-8pH
0.204 mPa s
Viscosity:
Not determined.
Kinematic viscosity
Not determined.
Dynamic:
Solubility
0.15 g/100g
water at 25 °C:
1.06 log POW
Partition coefficient n-octanol/water (log value)
0.665 MPa (6.79kgf/cm2 abs)
Vapour pressure at 25 °C:
Density and/or relative density
1.21 g/cm³
Density at 25 °C:
Not determined.
Relative density
3.52 g/cm³ (Air=1)
Vapour density
No further information available.
Particle characteristics
9.2 Other information:
Form:
Auto-ignition temperature:
Explosive properties:
Evaporation rate

Molecular weight 102.3
Liquefied gas>743
Not determined.
Not applicable.

Information with regard to physical hazard classes
Explosives
Flammable gases
Aerosols
Oxidising gases

Not applicableNot applicableNot applicableNot applicable(Contd. on page 5)56.0

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Trade name: HFC-134a(Contd. of page 4)

Gases under pressure
Contains gas under pressure; may explode if heated.
Not applicable
Flammable liquids
Not applicable
Flammable solids
Not applicableSelf-reactive substances and mixtures
Not applicable
Pyrophoric liquids
Not applicable
Pyrophoric solids
Not applicableSelf-heating substances and mixtures
Substances and mixtures, which emit flammable gases
Not applicablein contact with water
Not applicable
Oxidising liquids
Not applicable
Oxidising solids
Not applicable
Organic peroxides
Not applicable
Corrosive to metals
Not applicable
Desensitised explosives

SECTION 10: Stability and reactivity
10.1 Reactivity No further relevant information available.
10.2 Chemical stability
Thermal decomposition / conditions to be avoided: To avoid thermal decomposition do not overheat.
10.3 Possibility of hazardous reactions: No dangerous reactions known under normal conditions of use.
10.4 Conditions to avoid: Keep away from heat, sparks, flame, high temperature.
10.5 Incompatible materials: Alkali or alkaline earth metals - powdered Al, Zn, Mg, etc.
10.6 Hazardous decomposition products:
Fluorophosgene in contact with naked flame or red hot objects.
Hydrofluoric acid, carbonyl fluoride*SECTION 11: Toxicological information
11.1 Information on hazard classes as defined in Regulation (EC) No 1272/2008Acute toxicity Based on available data, the classification criteria are not met.
LD/LC50 values relevant for classification:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
Inhalative LC50/4h > 500000 ppm (Rat)
LCLo567000 ppm (Rat) (OECD 403)
Skin corrosion/irritation:
No slight irritation
PATTY (5 h , 2001 ) or irritation ECETOC JACC no.50) was observed in the rabbit test.
Serious eye damage/irritation:
No slight irritation
PATTY (5 h , 2001 ) or irritation ECETOC JACC no.50) was observed in the rabbit test.
after inhalation: No further information available.
Respiratory or skin sensitisation: Based on available data, the classification criteria are not met.
Germ cell mutagenicity:
In vitro tests did not show mutagenic effects.
In vivo tests did not show mutagenic effects.
As a result of conducting dominant lethal test(in vivo Generation mutagenicity test), micronucleus test andchromosomal aberration test Somatic cell in vivo mutagenicity test by inhalation exposure to mice, it came out asnegative in all tests, so it was out of Category.
(ECETOC JACC no.50)
Carcinogenicity:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
Inhalative NOEL 10000 ppm (Rat) (OECD 453)
As inhalation chronic toxicity · carcinogenicity in rats No evidence of tumor development by exposure test was found,it was judged that there was no carcinogenic effect.(ECETOC JACC no.50)(Contd. on page 6)56.0

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Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: HFC-134a(Contd. of page 5)

Reproductive toxicity:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
Inhalative NOEL 50000 ppm (Mouse) (OECD 478)
2500 ppm (Rabbit) (development) (OECD 414)
STOT-single exposure: Based on available data, the classification criteria are not met.(ECETOC JACC no.50)
STOT-repeated exposure:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
Inhalative NOAEC 50000 ppm (Rat) (OECD 453)
As a result of testing using rats, mice, dogs, no reports of hazards are found.(ECETOC JACC no.50)
Not classified
Aspiration hazard: As a result of testing using rats, mice, no reports of hazards are found. (ECETOC JACC no.50)
Other information (about experimental toxicology):
No further information available.
Chromosomal Abberation Study in
Chromosomal Aberration Study in vitro- Negative
Mouse Micronucleus Assay in Vivo - Negative
Subacute to chronic toxicity: No further information available.
Additional toxicological information:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
Inhalative Cardiac sensitive 75000 ppm (Dog)
The cardiac sensitization response is observed.
11.2 Information on other hazards:
Endocrine disrupting properties:
Substance is not listed.
*SECTION 12: Ecological information
12.1 Toxicity
Aquatic toxicity:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
LC50/96h 450 mg/l (Fish) (EU Method C.1)
rainbow trout
EC50/48h 980 mg/l (Daphnia) (EU Method C.2)
EC50/72h > 118 mg/l (Alga) (1,1,1,3,3-pentafluorobutane) (EU Method C.3)
12.2 Persistence and degradability: Not easily biodegradable
Abiotic degradation:
Air, indirect photo-oxidation
Conditions: sensitizer: OH radicals
Degradation products: Carbon dioxide (CO ) / hydrofluoric acid
Water: non-significant hydrolysis
12.3 Bioaccumulative potential:
Due to the distribution coefficient n-octanol/water an accumulation in organisms is not expected.
12.4 Mobility in soil:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
Henry's law constant 102 Pa*m³/mol (air) (25 °C)
log Koc
1.57 (soil)
12.5 Results of PBT and vPvB assessment
PBT: According to the results of its assessment, this substance is not PBT.
vPvB: According to the results of its assessment, this substance is not vPvB.
12.6 Endocrine disrupting properties For information on endocrine disrupting properties see section 11.
12.7 Other adverse effects:
Ecotoxical effects: no data
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Printing date 23.03.2023

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Trade name: HFC-134a(Contd. of page 6)

Behaviour in sewage processing plants:
CAS: 811-97-2 1,1,1,2-Tetrafluoroethane
EC50/6h > 730 mg/ml (Microorganisms)
Additional ecological information:
General notes:
Ozone depletion potential(ODP) : 0
Global warming potential(GWP) : 3,500 / IPCC Fourth Assessment Report (AR4)SECTION 13: Disposal considerations
13.1 Waste treatment methods
Recommendation:
Disposal must be made according to official regulations.
Incineration in an adequate incinerator is recommended.
Uncleaned packaging
Recommendation: Disposal must be made according to official regulations.
*SECTION 14: Transport information
14.1 UN number or ID number
ADR, IMDG, IATA
14.2 UN proper shipping name:
ADR, IMDG, IATA

UN31591,1,1,2-TETRAFLUOROETHANE (REFRIGERANT GAS R134a)

14.3 Transport hazard class(es):ADR

Class:
Label:
IMDG, IATA

2 Gases.
2.2

2.2 Gases.
Class:
2.2Label:
14.4 Packing group:
IIADR, IMDG, IATA
14.5 Environmental hazards:
No
Marine pollutant:Warning: Gases.
14.6 Special precautions for user:
20
Hazard identification number (Kemler code):
F-C,S-V
EMS Number:A
Stowage Category
14.7 Maritime transport in bulk according to IMO
Not applicable.
instruments
Avoid direct sunlight. Make sure of no damage, corrosion, leaks
Transport/Additional information:on the receptacles.
Take necessary measures for preventing cargo shift.
ADR
120 mlLimited quantities (LQ):(Contd. on page 8)

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Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: HFC-134a(Contd. of page 7)

Excepted quantities (EQ)
Tunnel restriction code:
IMDG
Limited quantities (LQ)
Excepted quantities (EQ)UN "Model Regulation":*

Code: E1
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 1000 ml
C/E
120 mlCode: E1
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 1000 ml
UN 3159 1,1,1,2-TETRAFLUOROETHANE (REFRIGERANTGAS R 134A), 2.2, II

SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Labelling according to Regulation (EC) No 1272/2008
The substance is classified and labelled according to the CLP regulation.
Hazard pictograms

GHS04
Signal word Warning
Hazard statements
H280 Contains gas under pressure; may explode if heated.
Precautionary statements
P410+P403 Protect from sunlight. Store in a well-ventilated place.
National regulations No further information available.
15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

SECTION 16: Other information
The product is for the industrial use only. We do not guarantee the safety in case the product is used for the otherpurposes. When using the product for health-care application or food/feed application, consult us in advance.
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specificproduct features and shall not establish a legally valid contractual relationship.
Department issuing SDS: EHS Department
Contact: http://www.daikin.com/Abbreviations and acronyms:
ADR: Accord relatif au transport international des marchandises dangereuses par route (European Agreement Concerning the International
Carriage of Dangerous Goods by Road)
IMDG: International Maritime Code for Dangerous Goods
IATA: International Air Transport Association
GHS: Globally Harmonised System of Classification and Labelling of Chemicals
EINECS: European Inventory of Existing Commercial Chemical Substances
DNEL: Derived No-Effect Level (REACH)
PNEC: Predicted No-Effect Concentration (REACH)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very Bioaccumulative
Press. Gas (Liq.): Gases under pressure – Liquefied gas* Data compared to the previous version altered.