Science Map

Institute of Post-LED Photonics, Tokushima University
2-1 Minamijosanjima-cho, Tokushima-shi, 770-8506
TEL：088-656-9701 FAX：088-656-9864
E-mail：postled@tokushima-u.ac.jp WEB：http//www.pled.tokushima-u.ac.jp※ Yellow = Previous research content Green = Current research content.

Wavelength

1000

(µm)

Terahertz

10100

Chief Research Officer (CRO) / Professor
YASUI Takeshi

Associate Professor
MINAMIKAWA Takeo

Infrared(100 μm–1 mm）

Visible light

Diagnosis of
myocardial infarction(0.7 μm–100 μm）

The terahertz region, characterized by a longer wavelength compared tothat of visible light, is widely recognized as the "final frontier" ofelectromagnetic waves, with continuous progress in its development. Itsability to penetrate solid objects has garnered attention as a potential
source of light for applications such as non-destructive inspection of
infrastructure and detection of foreign substances in food.

Given its ability to serve as a highly accurate ruler when shone upon
objects, the utilization of this technology in the realm of healthcare is
anticipated, particularly in areas such as diagnostic evaluations basedon the analysis of breath components.

THz comb

A THz comb is a frequency ruler that bridges theTHz gap located at the boundary between lightand electric waves. A wide range of industrial
applications will be possible by establishing ahighly reliable THz frequency standard
technology “THz comb”.

Professor
NAGASE Masao

New technology
High-speed, highresolution
transmission
measurement

Associate Professor
TOKIZANE Yu
Fabrication of large-area monocrystalline graphene

Scan-less THz
Microscopes

Fabrication of advanced devices using graphene

Development of graphene devices applicable to terahertz LEDs and high-performance IoT sensors

Raman spectroscopy can visualize biological tissue
function noninvasively

The electromagnetic waves that we commonly experience as "light"
can be perceived as colors by the human brain, the hue of which
varies as a function of its wavelength.

Interdisciplinary collaboration of medicine andphotonics aimed at improving postoperative QOL

Plastic
Package

Professor
YAMAMOTO
Kenji

Video research aimed at conveying a further sense of realism

Associate Professor
KUSE Naoya
Toward thecreation of superhigh quality

Professor
TAKAYAMA Tetsuji
Ultrabroadband
Technology

Microresonator optical frequency combs

Development of cost-effective and compact optical frequency combs and their applications toultrabroadband wireless/optical communications and photonic computing.

Immersive and stereoscopic images

Various research and development are being conducted for images that give a sense of realism, but
among them, we are researching shooting technology, information processing technology, anddisplay technology with a focus on stereoscopic images. Regarding photography techniques, we areconducting research on a camera for light field photography that can capture images in natural
colors. Regarding display technology, for example, we are researching displays that use holography,
and we are working on making it possible to display moving images that could previously only bedisplayed as still images.

Development of novel endoscopic diagnosis and phototherapy methods forcancer using special light

Development of fluorescent probes targeting molecules specifically observed in cancer cells,
development of molecular imaging diagnostic methods, and creation of novel light therapy thatcauterizes only cancer cells

Designated Assistant Professor
KATO Ryo

Associate Professor
YAMAGUCHI Kenzo

Professor
FUJIKATA JunichiInterdisciplinary Research of Minimally Intervention Dentistry and Photonics

Functional Optical Devices and Optical Integrated Circuits

We are researching optical information processing technology using functional optical devices andoptical integrated circuits to realize high-speed and high-capacity communications and neuralnetwork computing. Furthermore, we are researching optical and THz-waves seamless-connection
technology for Beyond5G next-generation information communications to realize low-carbon andsecure network society.

Dental caries affects all ages, and resin composite is key for its aesthetic and mechanical benefits.
Effective adhesion is vital for creating a durable 'super-tooth' interface. Using biocompatible
adhesives and photonics, we aim to investigate this interface's mechanics, aiming to innovate
minimally invasive treatments that benefit everyone from children to the elderly, while mitigating
economic impact.

Multifunctional plasmomechanical devices with on-chip integrated MEMS/NEMS
actuators
Surface plasmons (SPs), the collective oscillations of conduction electrons, can be supported metallic
nano-structures and manipulate the light in the nanoscale. This is one of key technologies combinedwith MEMS/NEMS for developing a nano-optical device to miniaturization and power efficiency.

Advanced optical spectroscopy using visible and infrared light and its biologicalapplications

The interaction of light and matter allows us to observe unique chemical, optical, and physicalproperties of samples. Our aim is to develop advanced bio-sensing and bio-imaging based on optical
spectroscopies, such as Raman and Infrared absorption spectroscopy for studying fundamental of
biological phenomena and for the early detection and treatment of diseases.

Physical properties of
medical nanomaterials

In recent years, Terahertz (THz) waves, positioned between radio waves and light, offer both radio
wave-like transmissivity and light-like directivity. This has sparked interest due to their excellent
material transmissivity and limited susceptibility to scattering. THz waves have also found theirapplication in dentistry. We are exploring the potential of incorporating THz wave imaging in dental
restorative procedures, aiming to enhance our understanding of caries and restorative treatment.

Order 𝑚 = 3

Transmitted optical vortex
Intensity

𝑚=3

Weak

Phase

Strong -π

𝑚=2

𝑚=1

𝑚=0

Development of Brillouin scattering microscope based on frequency combs
and application for the measurement of mechanical properties of biologicalmaterials.

𝑚 = −1

Fig.1 Spiral phase front characterizing optical vortices.
After compensation forphase fluctuation
Fluctuated optical vortex
Phase
Phase
Intensity
Intensity

Application of infrared combs to industrial measurement

Polarizing Devices/Polarizing Measurements

Health diagnosis of infrastructure concrete structures using near-infrared
spectroscopy

Microprocessing/flow channel device
development

Weak

Strong-π

OpticalTransmitter
Atmospheric turbulence(Spatial and temporal variations：Vortex for data
in refractive index due to：Vortex for detecting
atmospheric turbulence variations in temperature,pressure, wind, etc.）

+π

Weak

Strong-πProfessor
YANO Takaaki

Phasecompensation

OpticalReceiver- Phase profile detection- Compensation pattern calc.

Fig.2 Compensation of atmospheric turbulence effects on optical wireless communications using optical vortices.

Optical vortices are beams with orbital angular momentum (OAM) and orthogonal to each other with different
azimuthal orders. It is expected to increase the capacity of optical communications by using OAM multiplexing. The
spiral phase front characterizing optical vortices is shown in Fig. 1. In free-space optical wireless communication,
optical vortices are distorted by atmospheric turbulence. This study investigates methods to evaluate and compensate
for the effects of phase fluctuations caused by turbulence during atmospheric propagation of optical vortices.

Infrared comb-based
metrology

Designated
Assistant
Professor
HASE Eiji

・Line-scan doppler imaging
・Cascade link digital holography
・Scanless phase imaging

Example: Measurement of mechanical properties of cells with high-speed,
non-contact, and sub-cellular resolution.

Example of a
MEMS device
・Printer head・Digital Mirror
Devices・Light switch
・Light scanner
・Cantilevers for AFM
・Optical modulator
etc.…

Example: Doppler imaging at 1 line @ several GHz

In order to realize highly realistic and human-friendly image display, in addition to research on display
technology, it is necessary to clarify the characteristics of human vision.
We have clarified human visual perception mainly spatial perception and depth perception, and are
conducting research on technologies to apply these characteristics to displays.

Visualization of the electricalactivity of cells and tissues

Glucose solution

We will work on the application of polarized light
regardless of wavelength, from deep ultraviolet to THz
waves.

Associate Professor
TAKANARI Hiroki

Dispersionx

Research on processing technology anddevice manufacturing to advance optical measurement is also in progress.

Co-CRO/Professor
HARAGUCHI Masanobu

Thermal/stress sensors

Plasmonics and metamaterials for nanoscale manipulation of light in DUV, visible, infrared and THz
regions

Establishment of auxiliary morphological diagnosis methods combining
AI and machine learning, and development of rapid diagnostic methods
for heteromorphic cells using Raman scattered light analysis/mass
spectrometry with the aim of improving the quality of cancer diagnosis

Realization of new optical devices using functions derived
from nanostructures

Nano fabrication
technology

Development of nanoscale optical devices/structures
for highly sensitive optical sensing and imaging

Microscopic optical evaluation

Ez-TM12

Electromagnetic
numerical simulation|Ez|

In many organs such as the heart andnerves, the electrical activity of cells
controls various subsequent physiologicalactivities. We observe and analyze theFluorescence imaging ofelectrical activity of cells using
intracellular calcium
conventional patch-clamp
electrophysiological methods and opticalmapping methods using membrane voltagesensitive fluorescent dyesFurthermore,since conventional methods are complicatedand require the use of fluorescent dyes,
research and development is being carriedout aiming for a new technology thatmeasures membrane potential without Fluorescence imaging of membranestaining, labeling, or contact.
potential of mouse heart

Research and development of new cancer
diagnosis technology

Realization of new compact optical devices for sensing, light control, etc.
using optical localization and the electric field enhancement at the interface
between metal nanostructures and dielectric materials.
L=800 nm+π

Adaptive compensator

Professor
NAMBA Kosuke

Research on the development ofphotoresponsive organic molecules

Elucidation of the pathogenesis of intractable diseases anddevelopment of new diagnostic and therapeutic methods
Our goal is to clarify the pathogenesis of diseases that are difficult todiagnose and treat, such as autoimmune diseases, cancer, and infectious
diseases, at the molecular level, and to apply to medical treatment byintegrating it with the new technology of Institute of Post-LED Photonics.
【Research theme】
1.Identification of autoimmune disease-specific molecules and developmentof new diagnostic and therapeutic methods based on single-cell transcriptome
analysis
2.Elucidation of the pathogenesis of COVID-19 and development of new
diagnostic and therapeutic methods
3.Elucidation of the pathogenesis of intractable diseases by Raman
spectroscopy and development of new diagnostic methods.

The deep ultraviolet region is anticipated to play a central role as the
successor to mercury lamps in the treatment and sterilization of water.
Efforts are underway to realize a prolonged lifespan through the
suppression of internal crystal defects in LED technology, and to exploit
this capability in innovative ways across a wide range of fields, including
medicine, air purification, and cellular research.
Professor
NOMAGUCHI Masako

Development of highly luminescent organic molecules that can be applied todisplays, solid-state lasers, bioimaging, and photodynamic therapy, andchiroptical materials with circularly polarized luminescence that can beapplied to 3D displays and security inks.

Associate Professor
YAGISHITA Fumitoshi

Associate Professor
NAGAMATSU
KentaroHigh-temperature growth is realized byimitating jet engine gas flow metalorganic
vapor phase epitaxy.

(1 pm–380 nm)

Exploring the optical function of pi-electron organic molecules

Development of light-responsive moleculesthat express function in response to LED
irradiation of specific wavelengths, utilizing
the technology for synthesizing organic
molecules that glow by detecting specificcomponents in exhaled air

Optical functional nanomaterials
Advanced laser spectroscopy

Visual information processing/3D images

Research involving a wide range of wavelengths

Development of infrared comb-based measurement techniques for industrial
measurements, such as MEMS devices.

+π

Research on high-capacity opticalcommunication technology using optical vortices

Professor
UEDA Takao

Internal erosion of salt and sulfuric acid, one of the causes of aging of concrete, is measured byspectroscopy using near-infrared light to quantify the risk of collapse

Measuring mechanical properties of biological materials

Associate Professor
KISHIKAWA Hiroki
Phase front

Development of photothermal
composite-materials and devices
for nanosurgery applications.

Associate Professor
MIZUSHINA Haruki

No sample

Blood vessel

Integration of dental engineeringoffers the potential for innovative restorative dental treatments.

Ultraviolet /deep ultraviolet /
X-ray

0.001

Promotion of medical and optical collaborative
research in the field of viral infections.
We tackle to create a fundamental technology for"visualization" and "detection" of viruses by combining
virology and optics.

Development of an ultra-hightemperature MOVPE for deep
UV LEDs and a novel microscopefor observing crystal defectWe aim to realize deep UV LEDs at a long
lifetime by suppressing crystal defects.

K. Nagamatsu et al. Scientific Reports,12 (2022) 7662,

Associate Professor
KOMA Takaaki

Virus inactivation using deep
ultraviolet light

We will elucidate the mechanism of virus
inactivation by deep ultraviolet light andconduct research on differences ininactivation effects based on virus type.

Professor
FURUBE Akihiro

Designated
Associate Professor
EMOTO Akira

Associate Professor
YANAGIYA Shin-ichiro

Assistant Professor
YONEKURA
Kazuhide

Assistant Professor
OTSUKA Kunihiro

pathological mice models based on genetic analysisof immune and inflammatory diseases in humans andmice, and development of optical devices that can
detect blood molecules correlated with thepathological conditions

Ceramic
Condenser

Development of non-destructive measurement technology that takes advantage of the material permeabilityof terahertz light, the spectroscopic ability to distinguish materials, and the safety towards the human body

Professor
HOSAKA Keiichi

Assistant Professor Detection of biomolecules using new lighttechnology
TSUKUMO
Elucidation of disease mechanisms by analyzing
Shin-ichi

We aim to improve postoperative QOL by formulating
surgical procedures based on molecular function
sensing of biological tissue

Ripple effectNon-destructive terahertz wave
Development of novel measurement technology

Focusing on the electronic properties of graphene, which is expected to become a post-siliconmaterial, we established a graphene fabrication technology on single crystal SiC substrates.

Raman spectroscopy to visualize biological functions

0.01

Co-CRO/Professor
YASUTOMO Koji

Co-CRO/Professor
YASUTOMO Koji

(400 nm–700 nm）

Detection of
peripheral nerves

High speed and high resolution
Realization of non-destructive
testing

Tablet0.1

1

Integrate optical filter

5 µm

MicroMZ interferometer

1 µm

Metal multi slit lensProfessor
TSUNEYAMA
KoichiDevelopment of a time-resolved
spectroscopy system specialized for actual
device measurements based on a
femtosecond laser light source that glow
only for a very short period of time (10-13
seconds)

Professor
KAWATA Yoshiki

Associate Professor
OISHI Masatsugu
Development of UV wavelength identification device and solid-state lighting
using ceramic phosphors

Aiming to elucidate the pathogenesis of various diseases, we develop new integrated research withphotonics scientists, and promote the development of new light sources and devices.

This field is related to medical imaging and medical image analysis. We are working on threedimensional CT image processing algorithms, which are the core computer-aided technology mainly
based on three-dimensional CT images, and high-performance computer-aided technology that
supports lung cancer detection, differential diagnosis, and prediction of malignancy and prognosis
from three-dimensional CT images.

Assistant Professor
KATAYAMA Tetsuro

Professor
NAOI Yoshiki

Assistant Professor
TAKASHIMA Yusuke

Development of multifunctional LEDs and light sensors using sub-wavelengthnanostructures

Development of deep ultraviolet to visible range optical devices using highrefractive index sub-wavelength periodic structures

Associate Professor
SAKANE Ayuko
Basic research aimed at elucidating disease pathogenesis and creating opticaldevices leading to innovative diagnoses and treatments

Medical imaging and computing

Researches on the environmentally friendly-energy conversion devices which achieves highefficiency energy conversion such as fuel cells, storage batteries and solid-state lightings, with thegoal of contributing to the global environmental problems.

Associate Professor
OKAMOTO Toshihiro

Metamaterial development

Development of metamaterial fabrication technology that combines
nano processing and mass production

Elucidation and application development of novel phenomena derived frommetamaterials

Elucidation of novel phenomena such as negative refractive index, optical magnetism, and complete
light absorption, and the application to various sensors

Associate Professor
KOINKAR Pankaj Madhukar

Elucidation of reaction mechanisms
by spatio-temporal spectroscopy
Development of spatio-temporal spectroscopic measurement technology that can observe all chemical
species by combining pump probe measurement technique and single-molecule spectroscopic
measurement technique that can enable direct observation of chemical reactions.

Development of an integrated LED/optical sensor device focusing on single-layer sub-wavelengthnanostructures having a period slightly smaller than the wavelength of light for the wavelength rangeof ultraviolet to visible light.

Research in collaborative fields

Development of novel optical elements, sensors, and light-emitting devices in deep ultraviolet tovisible light regions using a high refractive index subwavelength periodic structure (SWS) withperiods smaller than optical wavelengths.

Sterilize with UV plus α

Sterilizing power can be improved with UV plus α (substances with weak
antibacterial activity, addition of low concentrations of antimicrobial agents)

Synergistic sterilizing power with light plus natural products
Used to control pathogenic microorganisms and spoilage-causing
microorganisms in the food and medical fields

Nanomaterials made with high-intensity lasers

Synthesis of two-dimensional nanomaterials is performed with pulsed laser ablation technology
in liquid
We aim to control integrated two-dimensional materials and apply them to energy-related
devices, such as optoelectronics and photocatalysts, utilizing metal nanostructures

Associate Professor
OHNO Yasuhide

Professor
SHISHIBORI Masami

Biosensors using epitaxial graphene

Development of multimedia systems utilizing AI technology

For graphene biosensors that had issues withreproducibility up until now, extremely high reproducibility
and sensitivity have been achieved using epitaxial graphene.

Development of intelligent multimedia systems such as cytology systems that detect cancer cells frommedical images (cell images) using AI technology, and detection systems of foreign objects in foodusing optical technology and deep learning model.

Disruption
membrane

Associate Professor
SHIRAI Akihiro

Decrease in viable cells