September 6th, 2022
FOR IMMEDIATE RELEASE
Company name
Representative
Inquiries
Phone

Premier Anti-Aging Co., Ltd.
(Securities code：4934 Tokyo Stock Exchange)
Kiyoshi Matsuura, President
Yuka Uehara,
Head of Corporate Communication Division
and Executive Officer+81-3-3502-2020

Notice concerning sales launch date of a new brand "Reinca"~New skincare brand with a core ingredient of novel stem cell culture supernatantdeveloped through joint research with the University of Tokyo~
Premier Wellness Science Co., Ltd. (Head Office: Minato-ku, Tokyo; Shinji Hosoyama, Chief ExecutiveOfficer), a consolidated subsidiary of Premier Anti-Aging Co., Ltd., announces that it will launch a new brand"Reinca" with "ENGY Stem S" as its core ingredient on September 21, 2022 (Wednesday).
“ENGY Stem S" is a unique dental-pulp stem cell culture supernatant specialized for skin care, which wasannounced as the first result of joint research conducted with the University of Tokyo.
The impact of this brand on the Company's consolidated financial results is negligible.

News Release

September 6th, 2022
Premier Wellness Science Co., Ltd.

Notice concerning sales launch date of a new brand "Reinca" with "ENGY
Stem S" as a core ingredient derived from a stem cell culture extract createdby advanced basic skin research.
Premier Wellness Science Co., Ltd. (headquartered in Minato-ku, Tokyo; Shinji Hosoyama, Chief
Executive Officer; hereinafter "PWS") is pleased to announce the launch of a new brand "Reinca"
which contains its core ingredient ENGY Stem S1, a unique dental pulp stem cell culture supernatant,which was previously announced based on the result of joint research2 with University of Tokyo.
The sales of "Reinca" will begin on Wednesday, September 21, 2022.

1. Brand overview

Reinca advocates skin cell care derived from advanced skin research and five-sense care that pursues
the comfort of physical sensation, based on the concept of facing the Root of Skin and Sense through thepower of science.
1

A unique dental pulp stem cell culture supernatant solution that was developed and commercialized as a result of thejoint research project "Development and commercialization of new functional materials using mesenchymal stem cell
culture supernatant solution" started on March 22, 2021 with the University of Tokyo National University Corporation.
https://p-wellnessscience.co.jp/info/20220902/

2

Joint research started on March 22, 2021 with the University of Tokyo National University Corporation: "Developmentof new functional materials using mesenchymal stem cell culture supernatant fluid and their practical application inproducts.
https://p-wellnessscience.co.jp/info/info-149/

Brand name

ReincaConcept

SKIN & SENCE

Core ingredient

ENGY Stem S (pulp stem cell culture supernatant)Market launch

Wednesday, September 21 st , 2022

Brand site

https://p-wellnessscience.com/reinca * Accessible from September 21 st , 2022, at 9 am

Announcement site

https://www.p-wellnessscience.com/reinca/teaser/

Brand BooK

https://p-wellnessscience.com/reinca/brandbook/ * Japanese language only

Official Instagram

https://www.instagram.com/reinca_globalofficial/

2. What is ENGY Stem S, pulp stem cell culture supernatant solution?

Stem cell therapy has been booming in the field of regenerative medicine. Stem cells have been thefocus of attention in cell therapy, however, recently the usefulness of "stem cell culture supernatant," aculture medium containing biological active factors secreted from cells has been discovered and is
expected to be as effective as transplantation of stem cells.
Based on this background, it is expected to have applications in not only for medicine but also in antiaging and others. In contrast, there are existing challenges that need further research before practicalapplication, such as highly transparent traceability, several safety assessments, scientific evaluation of theactive ingredients in the culture medium, and demonstration of efficacy in humans.
To work through these challenges, we conducted joint research with the University of Tokyo, we havesucceeded in developing and commercializing ENGY Stem S.

OriginHuman adult dental pulp stem cells

Culture method

The University of Tokyo's original culture medium and culture method (cannot be disclosed
due to IP rights)

Contained protein

More than 2,145 proteins (global analysis by DIA proteome analysis3 )

species
Traceability

Donor with consent obtained at the University of Tokyo Hospital
Transparent traceability through ID management

3

Batch analysis and identification of all the proteins contained in a solution. A state-of-the-art analysis technology thatanalyzes what kind of protein is contained and in what quantity. It is widely used in medical research such as cancer andCovid-19 research.

Safety

Meet safety criteria for biological products, such as microbiological and viral tests.
Meet safety criteria for topical application such as primary skin irritation and skinsensitization.

2. For interviews and inquiries regarding this release
Premier Wellness Science Co., Ltd.
PR/IR contact: pws-prir@p-wellnessscience.co.jp
As part of our measures to prevent the infection of the new coronavirus, our group is working by telework.
Please contact us by using the above e-mail address for inquiries.

3. Regarding this release
The information in this news release is current as of the date of publication. It is subject to change
without notice due to various factors. Please understand this in advance.