Confident
quantitation
A new level of confidence

Thermo Scientific TSQ Fortis
triple quadrupole mass spectrometerFast and robust quantitation for every
Environmental and Food Safety workflow
Offlinesamplepreparation

Chromeleon™ CDSMILKFood and Environmental Safety Workflow
TraceFinder™

Onlinesamplepreparation

With evolving challenges in environmental and food safety
applications, it’s important to have the right platform for
performing confident quantitation of multiple analytes in
a complex mixture. The Thermo Scientific™ TSQ Fortis™
triple quadrupole mass spectrometer provides superiorrobustness—enabling round-the-clock operation and theability to report reliable results, rapidly.

• Increased robustness—Active Ion Management Plus (AIM+)
includes the Matrix Separator Ion Guide (MSIG)—ensuresextended system uptime by keeping the ion path clean• Maximum productivity—fast turnaround times while
ensuring excellent quantitative results for extended listsof contaminants• Designed for more ease—comprehensive workflows
enabled by software that ensure confident analysis

Quantitation of contaminants in environmental
samples at regulatory levels

Haloacetic acids in drinking water2Quantitation of pesticides in food samples at regulatory levels

High throughput with ease of use forClinical Research and Forensic Toxicology

Singlechannel

Clinical Research and Forensic Toxicology Workflow

TraceFinder™

Multichannel
food enviro workflow

The TSQ Fortis MS provides a seamless user experiencefor clinical research laboratories that focus on processing
and analyzing a large number of samples. Designedfor ease, the TSQ Fortis MS platform enables confident
quantitation of hundreds of samples in complex matrices,
every day.

Consistent performance under challenging conditions• Usability—simplified user maintenance and intuitive
software experience• High throughput—analyze hundreds of samples andnumerous compounds with short turnaround times

Precision, accuracy and sensitivity for demanding applications

Cyclosporin A in whole blood

400

Calculated Concentration (µg/mL)• Enhanced robustness—AIM+ and the MSIG enablethroughput by extending system uptime

350

+20%

300

CV = 3%

250
200
150

-20%

100
5000500

1000

1500

2000

Number of matrix injections

For Research Use Only. Not for use in diagnostic procedures.

3

Reliability and sensitivity to meet
Pharmaceutical requirements
High-flowapplications

Pharma and Biopharma Quantitation Workflow

Chromeleon™ CDS

Highthroughput

Pharmaceutical laboratories require ultimate reliability andthe ability to achieve desired sensitivity to meet analyticaldemands. The TSQ Fortis MS provides more ease andcomprehensive workflows empowering the daily
quantitative requirements of pharmaceutical labs.

• Outstanding reliability—robust and reproducible data
for all molecule types provided by AIM+ and the MSIG
• Sensitivity to meet demands—segmented quadrupoles
facilitate ion transmission with system-to-system
reproducibility• High-throughput quantitation—multiple liquid
chromatography (LC) options combined with the speed of theTSQ Fortis MS help analyze hundreds of samples every day

Ultimate productivity for QA/QC workflows

4

Companion solutions
for the TSQ Fortis massspectrometer

Chromatography solutions for MS
The TSQ Fortis mass spectrometer can be pairedwith a range of high-performance Thermo Scientific™
inlet systems.

Workflow-driven software, solutions, andsupport streamline your applications• Thermo Scientific™ Vanquish™ Flex, Horizon and Duo
UHPLC systems

Integrated workflow-driven software and solutions
streamline everyday tasks from instrument
optimization and troubleshooting to routine method
development and results reporting.

• Thermo Scientific™ Transcend™ II system with
Multi-channel and TurboFlow™ technology• Thermo Scientific™ Prelude SPLC™ system with
Multiplexing and TurboFlow™ technology• Thermo Scientific™ Dionex™ Integrion™ HPIC™ system

Thermo Scientific™
TraceFinder™ software
Comprehensive quantitative
workflows for all applications—from method development toreport generation

AppsLab method library
A comprehensive repository forapplication methods, data sets,
and application notes

Thermo Scientific™
Chromeleon™ software
Offers enterprise instrument
control, data processing, and ability
to address regulatory requirements

Our global Centers of Excellence, in-your-lab
training using your methods, and AppsLab Libraryof Analytical Applications, ensure your success.

5Experience confident quantitation:
TSQ Fortis MS with AIM+ Technology
Active collision cell with axial DC field
Enables ultra-fast selected reaction
monitoring (SRM).

Matrix Separator Ion Guide (MSIG)
Maximizes robustness while
minimizing ion loss.

Robust, innovative design
Benefits of the TSQ Fortis mass spectrometer
More samples, more compound classes

Robust quantitative productivity

The reliable instrument design, intuitive software, andcomprehensive workflow solutions developed with theTSQ Fortis triple quadrupole mass spectrometer help
ensure superior productivity for quantifying hundreds ofcompounds of all types—in any matrix, by any user.

The TSQ Fortis triple quadrupole mass spectrometer isdesigned to meet demands day after day, for every sample
type in a variety of matrices. In addition to robustness andreproducibility, the TSQ Fortis mass spectrometer provides
unprecedented ease of use.

6

Active Ion Management
Plus (AIM+)
Enhanced dual-mode discrete-dynode electron
multiplier detector
Extends multiplier lifetime with increased surface area.
Maintains excellent linearity and dynamic range.

QR4 Segmented Quadrupole mass filter withhyperbolic surfaces
Simplifies day-to-day operation by ensuring consistent
performance and reproducible results acrossinstruments and over time for increased productivity.

Ion beam guide with neutral blocker
Provides robust performance and maximum
sensitivity by blocking neutrals and efficiently
transmitting ions.

The next step in precision design delivers the ultimate
in ion management, inception to detection, from theThermo Scientific™ OptaMax™ NG ion source housing
to the enhanced electron multiplier. AIM+ incorporates
segmented quadrupoles and enhanced RF electronics
to further optimize ion management precision, reliability,speed, and reproducibility.

Robustness by design
The TSQ Fortis triple quadrupole mass spectrometeris designed with robustness in mind. Regardless of
your application, the TSQ Fortis mass spectrometer will
deliver results reliably and consistently, day after day.

OptaMax NG ion source APCI ready
Automates all gas and voltage connections forease of use. Provides optimizable spray position
for ultimate performance in HESI or APCI mode.

Ion transfer tube and sweep cone
Provides maximum robustness andtool-free maintenance.

Confident data: technology translated to resultsYour everyday partner for confident quantitation

The TSQ Fortis mass spectrometer equipped with
the neutral blocker, ion beam guide, and segmented
quadrupoles is designed to deliver robust performance.

The TSQ Fortis MS system software is an intuitive package
designed to ensure ultimate productivity.

Speed with selectivity and sensitivity
The TSQ Fortis mass spectrometer delivers excellent
quantitative performance in both selected reaction
monitoring (SRM) and high-resolution SRM (H-SRM)
modes, even when operated at short dwell times.

• Simple maintenance—easy clean-up of ion transfer
tube without breaking vacuum• High speed and automation—address hundreds ofsamples per day, or hundreds of transitions per sample• Intuitive drag-and-drop method editor—softwarewith application-based templates helps simplify method
development and operation
7

Transforming triple quadrupole
mass spectrometers
The TSQ Fortis mass spectrometer is one in a family of latest-generation Thermo Scientific™ triple
quadrupole mass spectrometers that offer confident quantitation every day, for every lab and every user.
These instruments are built on a foundation of shared, state-of-the-art hardware and software components.
This makes it easier to transfer methods from one instrument to another when methods progress fromsingle, sample-based experiments to validation and routine high-volume screening and quantitation.

ALM

Almanac web-based monitoring and management
The ability to remotely access and manage your LC-MS and GC-MS systems lets you focus on other importanttasks during your day. Using the Almanac phone App, Instrument Connect or web-based application, you cancheck real-time system status and acquisition, set up automated e-mails to notify you of a completed
acquisition or error, schedule instrument access, monitor utilization, or submit information to service personnel
to aid in instrument diagnostics. thermoﬁsher.com/almanac
Technical and online support: peak performance for your instruments
Helping you keep your instruments running at peak performance is our goal. Whether you’re looking for an
instrument manual or spare parts, want to submit a repair request, or check on the status of your warranty orservice contract, we have every support option you’re looking for. thermoﬁsher.com/technicalresources

Simplify Service

Protecting your investments: unparalleled laboratory services
Unity™ Lab Services provides a single source for integrated lab service, support, and supply management. Our
customized service offerings and world-class service experts have the flexibility and experience to effectively
address your laboratory’s business needs. We provide a complete portfolio of services and support solutions
designed to help you improve productivity, reduce total cost of ownership, and ensure performance throughout
your laboratory—from instrument and equipment acquisition to disposition. unitylabservices.com

Find out more at thermofisher.com/Fortis
For Research Use Only. Not for use in diagnostic procedures. © 2018 Thermo Fisher Scientific Inc. All rights reserved.
All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. BR65172-EN 0819M