Kyoto University - University of Zurich
Strategic Partnership Joint Symposium 2023
- Data Science and Social Impact -Contents
Objective of the Symposium ………………………………………………………………………. P. 1
Welcome Messages and Profiles of Executive Staff ………………………………..… P. 2
Nagahiro Minato (President, Kyoto University)
Michael Schaepman (President, University of Zurich)
Christian Schwarzenegger (Vice President, University of Zurich)
Kyoko Inagaki (Executive Vice-President, Kyoto University)
Yasuyuki Kono (Vice President, Kyoto University)

Overall Program ……………………………………………………………………………………….. P. 8
Opening Presentation: The Trajectory and Future of the Strategic Partnership ……. P. 1 1
Hirohide Saito (Kyoto University)
Melanie Generali (University of Zurich)
Moe Hirosawa (Kyoto University)

Data Science and Social Science………………………………………………………………….. P. 1 5
Hiroki Habuka (Kyoto University)
Peter Georg Picht and Florent Thouvenin (University of Zurich)Yasuyuki Echi (Kyoto University)
Tatsuhiko Inatani (Kyoto University)
Misaki Sumida (Kyoto University)

Early Career Researchers’ Forum .……………………………………………………………….. P. 2 1
Data Science and Natural Science.……………………………………………………………….. P. 2 3
Kentaro Shimizu (University of Zurich)
Shuhei Nasuda (Kyoto University)
Michael Krauthammer (University of Zurich)
Koji Fujimoto (Kyoto University)
Kerstin Noëlle Vokinger (University of Zurich)Objective of the Symposium
To advance its development as a university that generates world-classknowledge, Kyoto University collaborates with other leading universities aroundthe world. In 2013, the university concluded an agreement for academic
cooperation and exchange with the University of Zurich, followed by a student
exchange agreement in 2014. The conclusion of those agreements led to a
deepening of exchange and collaboration between the two institutions,particularly in the fields of medicine, life science, and plant science. Based on
the achievements made, a strategic partnership agreement was concluded by
the two universities in July 2020. The strategic partnership, which is conductedunder the leadership of the university presidents, seeks to promote the crossdisciplinary development of existing research and joint research in new fields,
cultivate early-career researchers, and build a long-term collaborative
relationship between the two universities through educational exchange.
Through its partnership with the University of Zurich, Kyoto University is
promoting joint research and the exchange of early-career researchers. Joint
research is being actively undertaken in the fields of medicine, plant science,and law, and collaboration on new research themes is also being initiated.
The Kyoto University-University of Zurich Strategic Partnership Joint
Symposium 2023 will enable collaborating researchers to share theirexperiences and review the achievements of the strategic partnership to date.
Also, under the theme of “Data Science and Social Impact,” the symposium will
present joint research in the social and natural sciences on the ways that data
science and AI can impact research and society as a whole, as well as aspects
that should be considered for the future. It will also serve as a platform for the
discussion of those topics.
Each session will endeavor to take a cross-disciplinary approach based on data
science, in alignment with the aims of the strategic partnership.

㻝Welcome Messages
andProfiles of Executive Staff

2

Nagahiro Minato
President of Kyoto University

It is my great pleasure to welcome you to Kyoto University for the Kyoto UniversityUniversity of Zurich Strategic Partnership Joint Symposium 2023.
Our first joint symposium was held at the University of Zurich in November 2013 andan academic exchange agreement between Kyoto University and the University of
Zurich was also concluded at that time. The symposium marked a great step forwardin the collaboration between our two institutions, and between our researchers. Since
then, we have held a further joint symposium in 2016 and a joint workshop in 2019,
and I am delighted that the global COVID-19 pandemic that has hamperedinternational exchange in recent years has now abated sufficiently to allow us to holdthis current joint symposium.
Upon my appointment as president in 2020, I set “the internationalization of research
activities and dissemination of research results” as one of my core presidential
priorities, and I consider our strategic partnerships with other leading universities
around the world to be a key component of those efforts. We are very selective inchoosing our strategic partners, and have concluded only five strategic partnershipagreements since the initiative was launched four years ago. Our partnership with the
University of Zurich was formalized in 2020, and we are deeply satisfied with theresulting development and expansion of our collaboration on research and otherexchange activities.
I hope that the opportunities for knowledge-sharing and collaboration provided by this
symposium will boost our collaborative research efforts, and ultimately contribute to
the advancement of our greater overarching goals of addressing large-scale global
issues and achieving sustainable development. In years to come, I hope that the
symposium will be remembered as a major step forward in the history of collaboration
between Kyoto University and the University of Zurich.

3

Michael Schaepman
Presidentof University of Zurich

The “Kyoto University – University of Zurich Joint Symposium” is awonderful platform to make the excellent research visible that is
conducted between our two universities. This symposium is proof
that our strategic partnership continues to get stronger and stronger,
and I would like to express my appreciation to everyone involved formaking this happen.
I particularly like the fact that the symposium involves so many early
career researchers: It offers them an opportunity to establish
connections, talk about their findings and gain a unique experience
for their future career in academia. I am certain that this event willcontribute to an even deeper alliance between our universities andthat it will foster an innovative environment and lots of new ideas.
I regret that I will not be able to attend the event in person and am
thankful to Vice President Christian Schwarzenegger for
representing the Executive Board of the University of Zurich at this
symposium. I wish everyone involved a productive and successful
event, and I look forward to hearing all about the results andprogress made during these two days.

4Christian Schwarzenegger
Vice President Faculty Affairs and Scienctific Information
University of Zurich

On September 16, 2022, Professor Shinya Yamanaka, Kyoto University, helda lecture about future developments of induced pluripotent stem cell research(iPSC) at the University of Zurich. Before the lecture and not less importantly
he participated in a scientific exchange with young researchers to discuss iPSC
and translational cell-therapy approaches. The research collaboration between
Center for iPS Cell Research and Application (Kyoto University) and Institutefor Regenerative Medicine (University of Zurich) started in 2017 and is stronger
than ever before. Meanwhile, from July to December 2022, five professors from
University of Zurich spent a sabbatical at Kyoto University, ranging from law,
psychology to linguistics and sinology. As a result of these exchanges, a new
joint research group in AI Regulation and Intellectual Property has been
formed. The members will contribute to this very symposium.
These are only two examples of what a true partnership of leading universities
can achieve. These cooperations foster new ideas, contribute to academic
excellence and cutting-edge research on both ends. They encouragetranslation of research resulting in clinical application or leading to policy
recommendations.
Over the past years, we have had the privilege of working together on a wide
range of projects and initiatives in the fields of Medicine, Biology, Chemistry
and Law, just to mention a few. I am particularly happy about the fact that thistime young researchers from Kyoto University and University of Zurich join the
symposium to share their knowledge and expertise. As we look in the future, I
am excited to see the ways in which our strategic partnership will continue to
evolve and grow. I am confident that we will continue to push the boundaries ofwhat is possible and make a meaningful impact on the world.
I would like to take this opportunity to express my appreciation for the hard workand dedication of everyone involved in making this partnership a success.

5

Kyoko Inagaki
Executive Vice-President for Gender Equality,
International Affairs and External Affairs
Kyoto University

Education record:
1987

B.A. in Education, Faculty of Education, Kyoto University

1981

M.A. in Sociology of Education, Graduate School of Education, Kyoto
University

1981-1983

Doctoral program in Sociology of Education, Graduate School of
Education, Kyoto University

2009

Ph.D. in Sociology of Education, Graduate School of Education, Kyoto
University

Job record:
Apr. 1983–Mar.1985

Lecturer, Teikyo University Junior College

Apr. 1985–Mar. 1988

Lecturer, Faculty of Education, Shiga University

Apr. 1988–Sept. 1996

Associate Professor, Faculty of Education, Shiga University

Oct. 1996–Mar. 1998

Associate Professor, Faculty of Education, Kyoto University

Apr. 1998–Mar. 2005

Associate Professor, Graduate School of Education, Kyoto University

Apr. 2005–Mar. 2021

Professor, Graduate School of Education, Kyoto University

Apr. 2014–Mar. 2017

Vice-Dean, Graduate School of Education, Kyoto University

Apr. 2015–Mar. 2020

Member of the Education and Research Council, Kyoto University

Apr. 2016–Mar. 2020

Director, Faculty Consort for Education, Kyoto University

Apr. 2017–Mar. 2020

Dean, Graduate School of Education, Kyoto University

Oct. 2020 –Executive Vice-President for Gender Equality, International Affairs, andExternal Affairs (University Fund Administration and Alumni Affairs),
Kyoto University6

Yasuyuki Kono
Vice-President for International Strategy
Kyoto University 

Education record:
Mar. 1981

Bachelor degree, Faculty of Agriculture, The University of Tokyo

Mar. 1983

Master degree, Graduate School of Agriculture, The University of Tokyo

Mar. 1986

Doctor degree, Graduate School of Agriculture, The University of Tokyo

Job record:
Apr. 1986-Jul. 1987

JSPS Postdoctoral Fellow
Graduate School of Agriculture, The University of Tokyo

Jul. 1987-Aug. 1992

Assistant Professor
Center for Southeast Asian Studies, Kyoto University

Aug. 1992-Aug. 1994

Assistant Professor
Irrigation Management and Engineering Program Asian Institute ofTechnology

Aug. 1994- Jul. 1998

Assistant Professor
Center for Southeast Asian Studies, Kyoto University

Aug. 1998-Dec. 2005

Associate Professor
Center for Southeast Asian Studies, Kyoto University

Dec. 2005-Now

Professor
Center for Southeast Asian Studies, Kyoto University

Apr. 2010-Mar. 2014

Vice Director
Center for Southeast Asian Studies, Kyoto University

Apr. 2014-Mar. 2018

Director
Center for Southeast Asian Studies, Kyoto University

Apr. 2018-Now

Vice President for international strategy, Kyoto University

May. 2018-Oct. 2020

Director, Kyoto University European Center

Nov. 2020-Mar. 2022

Director, Kyoto University North American Center

7

Overall Program8

1st Day (2023/3/7)
Time

ActivityVenue

9:00-9:30

Arrivals and Registration

9:30-10:05

Opening Ceremony

9:30-9:35

Opening Address by Representative of Kyoto University- Nagahiro Minato (President)

9:35-9:45

Opening Address by Representative of the University of Zurich-Michael Schaepman (President) (video message)-Christian Schwarzenegger (Vice-President)

9:45-9:50

Address by Representative of Swiss Embassy-Andreas Baum (Ambassador of Switzerland to Japan)

9:50-9:55

Exchange of Gifts

9:55-10:05

Group Photo

Shiran Kaikan
Shiran Kaikan (Inamori Hall)

10:05-10:15

Break

10:15-11:45

Opening Presentation: The Trajectory and Future of the Strategic Partnership

10:15-10:30

Presentation: Looking Back on the KU-UZH Strategic Partnership-Yasuyuki Kono (Vice-President, Kyoto University)

10:30-10:50

Presentation: The Strategic Partnership’s Contribution to Fostering Early Career
Researchers-Hirohide Saito (Kyoto University)-Melanie Generali (University of Zurich)

10:50-11:45

Opening Dialogue-Yasuyuki Kono (Kyoto University)-Hirohide Saito (Kyoto University)-Melanie Generali (University of Zurich)-Moe Hirosawa (Kyoto University)

Shiran Kaikan (Inamori Hall)

11:45-13:15

Lunch BreakShiran Kaikan Annex: Catering

13:15-15:15

Data Science and Social Science

Shiran Kaikan (Inamori Hall)

13:15-15:15

Presentations and Panel Discussion-Hiroki Habuka (Kyoto University)-Peter Picht (University of Zurich)-Florent Thouvenin (University of Zurich)-Yasuyuki Echi (Kyoto University)-Stephanie Volz (University of Zurich)-Tatsuhiko Inatani (Kyoto University)-Misaki Sumida (Kyoto University)9

2nd Day (2023/3/8)
Time

ActivityVenue

9:00-9:30

Arrivals and Registration

9:30-12:30

Early Career Researchers' Forum

9:30-9:45

Address by the Consulate General of Switzerland in Osaka/Swissnex-Felix Moesner (Consul/CEO)

9:45-10:00

Presentation on Funding Opportunities for ECRs

10:00-12:30

Presentation and Discussion*For participants, please refer to page 22.

Shiran Kaikan
Shiran Kaikan (Yamauchi Hall)

12:30-14:00

Lunch BreakShiran Kaikan Annex: Catering

14:00-16:30

Data Science and Natural Science

Shiran Kaikan (Inamori Hall)

14:00-16:30

Presentations and Panel Discussion-Kentaro Shimizu (University of Zurich)-Shuhei Nasuda (Kyoto University)-Michael Krauthammer (University of Zurich)-Koji Fujimoto (Kyoto University)-Kerstin Noëlle Vokinger (University of Zurich)

16:30-16:45

Coffee BreakShiran Kaikan (Yamauchi Hall)

16:45-17:10

Closing Ceremony

Shiran Kaikan (Inamori Hall)

16:45-17:00

Plenary Wrap-Up Session-Christian Schwarzenegger (Vice-President, University of Zurich)

17:00-17:10

Closing Remarks by Representative of Kyoto University-Kyoko Inagaki (Executive Vice-President)

17:10

End of Symposium

10

Opening Presentation:
The Trajectory and Future of
the Strategic Partnership11

Hirohide Saito
Professor
Center for iPS Cell Research and Application (CiRA) Kyoto University

New cell purification method for next-generation cell therapy
Induced pluripotent stem cells (iPSCs) are promising cell resources for future
clinical applications. However, differentiated cells derived from iPSCs areheterogeneous. Thus, a robust cell purification method is needed. MicroRNAs(miRNAs) can be used as a marker for target cells, as their activity differs
between cell types. We have developed miRNA-responsive mRNAs that
regulate protein expression levels in target cell. Using these mRNAs, we havecollaborated with the Institute for Regenerative Medicine (IREM), the Universityof Zurich to purify clinical-grade cardiomyocytes derived from iPSCs. I would
like to discuss about the importance of international collaborations and futurechallenges in the field.
Keywords:
Regenerative medicine, Cell therapy, mRNA, iPS cells
CV:
Born in Osaka, Japan, 1973
Doctor of Engineering (PhD), Department of Chemistry and Biotechnology,
Graduate School of Engineering, The University of Tokyo, Japan, 2002
Website: https://www.cira.kyoto-u.ac.jp/e/research/hsaito_summary.html
Hirohide Saito is a Professor at the Center for iPS Cell Research andApplication (CiRA), Kyoto University. After completing predoctoral training at
the University of Tokyo and SUNY Buffalo, he received his PhD from the
University of Tokyo in 2002. He joined CiRA in 2011. He is interested in thefields of synthetic biology & cell programming. Using newly developed RNA
technologies, he aims to understand the design principles of living systems andcontribute to future medicine.

12Melanie Generali
Head of iPSC Core Facility (iPSCore)
Medical Faculty / Institute for Regenerative Medicine
University of Zurich

Next-generation cell-based therapy for myocardial infarction
Over the past decade, the field of cell therapy has rapidly expanded with the aim to
replace and repair damaged cells and/or tissue. Here we focus on the treatment of
myocardial infarction, where currently available treatment options are not able toregenerate lost healthy heart tissue. Good manufacturing practice (GMP)-compatible
cardiomyocytes (CM) were generated from transgene- and xeno-free induced
pluripotent stem cells (iPSCs). To ensure a pure CM population for in vivo applications,
we reduced the risks of iPSC contamination. In collaboration with Center for iPS Cell
Research and Application (CiRA, Kyoto, Japan), RNA-switch technology was used toensure a pure CM population for safe clinical applications. For our next step, we aim
to specifically target these cells towards the ischemic environment of myocardial
infarction for next-generation cell-based therapies.

Keywords:
induced pluripotent stem cells (iPSC), clinical translation, myocardial infarction

CV: Dr. Melanie Generali first studied biology in Germany and later in Switzerland.
During her PhD at the IREM, she manufactured iPSC-based tissue-engineered vasculargrafts. Later, she worked as a postdoctoral fellow on a project in close collaboration with
the CiRA to regenerate ischemic heart tissue. In July 2021, she launched the iPSC Core
Facility (iPSCore) at the UZH where she is now the program head. Furthermore, she is
the representative of Switzerland in the European Network for Stem Cell Core Facilities(CorEuStem). Since end of 2022, she has been working as the head of cardiovascular
tissue engineering and leading the new collaboration with the Nationwide Children’s
Hospital, Columbus, US.

13

Moe Hirosawa
Researcher
Center for iPS Cell Research and Application (CiRA)
Kyoto University

Purifying differentiated cells derived from induced pluripotent stem cells(iPSCs) is important for future clinical applications. MicroRNAs (miRNAs) are a
candidate for detecting target cells because miRNA activity differs between cell
types. Our laboratory developed miRNA-responsive ON and OFF mRNAswitches in which protein expression levels are regulated by target miRNA. We
and the Hoerstrup group at the Institute for Regenerative Medicine (IREM),
University of Zurich, which has the technology to differentiate cells, try to purify
the iPSC-derived endothelial cells and cardiomyocytes from heterogenous cell
populations with these mRNA switches.

Keywords:
Cell purification, Synthetic biology, microRNA, mRNA switch, iPS cells

CV:
Place of Birth: Japan
Date of Birth: December 18th
Research interests: Genome editing, Stem cells, Aging, Synthetic biology
Education: Medical Science (PhD), Graduate School of Medicine, Kyoto
University, Kyoto, Japan, 2019
Employment History: 04/2019 - Present, Researcher, CiRA, Kyoto
University, Kyoto, JapanWork Email: moe.hirosawa@cira.kyoto-u.ac.jp
Office Address: 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507,
Japan

14

Data ScienceandSocial Science15

Hiroki Habuka
Research Professor
Graduate School of Law, Center for Interdisciplinary
Studies of Law and Policy (CISLP)
Kyoto University

Designing Collaborative and Agile Governance for Society 5.0
On one hand, innovation in cyber-physical systems (CPSs) has brought
tremendous benefits to our daily lives. On the other hand, it has led touncontrollable risks to privacy, security, and other fundamental values. To
tackle these risks and maximize the positive impact of such new technologies,
we need a dynamic reform of society-wide governance. Considering this, theJapanese government issued three policy papers regarding “agile
governance,” which is a distributed and coordinated governance model rather
than the traditional command-and-control model. Prof. Hiroki Habuka, the leadauthor of those reports, will present why we need innovation in governance andhow to implement it in society.
Keywords:
Governance, Multi-stakeholder, Agile, Cyber-Physical Systems, System of
Systems, Data, AI
CV:
Hiroki Habuka specializes in agile governance, which is a multi-stakeholder,agile, and multi-layered framework for governing a fast-changing and complex
society. He is the lead author of white papers discussing agile governancepublished by Ministry of Economy, Trade and Industry, Japan (METI), namely,“GOVERNANCE INNOVATION Ver.1” (2020), “GOVERNANCE INNOVATION
Ver.2” (2021), and "Agile Governance Update" (2022). In 2020, he was selectedby the World Economic Forum Global Future Councils on Agile Governanceand Apolitical as one of the World’s 50 Most Influential People Revolutionizing
Government (Agile 50).

16

Peter Georg Picht

Florent Thouvenin

Professor

Professor

Faculty of Law / Chair for Business,

Faculty of Law / Chair for Information andCompetition and Intellectual Property Law

Communications Law

University of Zurich

University of Zurich

Artificial Intelligence (AI) and Intellectual Property (IP): A European
Perspective
The presentation will give an overview of the current state of AI-generated art
and Intellectual Property Law in Europe. In doing so, it addresses key AI/IP
issues, including business models of AI
innovation leaders,inventorship/creatorship of AI systems de lege lata and de lege ferenda as wellas the DABUS litigation about patentability of AI-generated inventions. In a joint
research project, the Zurich AI/IP Group focused on questions of whether new
types of IP rights are necessary to protect AI inventions, AI’s potential raising
the bar-effect, the allocation of entitlements and liability regarding suchinnovations, and the need for new protection carve-outs.
Keywords:-

Artificial Intelligence (AI) – de lege lata and de lege ferenda-

Intellectual Property Law (Patent Law and Copyright Law)

-

DABUS

-

Policy Recommendations

17

Yasuyuki Echi
Professor
Graduate School of Law
Kyoto University

AI-generated Content and Copyright
In recent years, image-generating artificial intelligence (AI) such as “Stable
Diffusion” and “Midjourney” have been developing rapidly. We are entering an
era in which anyone can easily generate content by using AI. My presentation
will address the topic of whether AI-generated content can or should beprotected by copyright law.
Traditionally, only creations by human beings are thought to be eligible forcopyright protection. Hence, in many countries, AI-generated content is notprotected by copyright law. My presentation will discuss the need for copyrightprotection of AI-generated content.

Keywords:
AI, CopyrightCV:
Professor, Graduate School of Law, Kyoto University, 2016-present
Associate Professor, Graduate School of Law, Kyoto University, 2004-2016
Research Assistant, Graduate School of Law, Kyoto University, 2001-2004

18

Tatsuhiko Inatani
Professor
Graduate School of Law
Kyoto University

Governance Innovation & Beyond: Law in Society 5.0
Society 5.0 is the ideal figure for Japan’s future society, where physical andcyber systems are seamlessly integrated to solve social issues and stimulateinnovation that enables sustainable economic growth. However, theemergence of a complicated, dynamic, and colossal system would raise
serious issues requiring novel governance. Otherwise, we cannot fully benefit
from Society 5.0. In this lecture, I explain a novel governance system for, by,and of innovation (“Governance Innovation”) and the issues to be explored
more under the novel governance system.

Keywords:
Governance System for Digitalized Society, Automated GovernanceCV:
Tatsuhiko Inatani is a Professor of Law at Kyoto University. His scholarship
focuses on law and technology matters and globalized corporate crime. He has
published several influential books and articles about privacy protection in adigital era, the risk governance system of intelligent systems, and the legal
philosophy of AI and robots. He is a member of several government
committees, including study groups on a new governance model in “Society
5.0” (Ministry of Economy, Trade, and Industry) and future vision ofautonomous robots (Information-Technology Promotion Agency-Digital
Architecture Design Center) and a working group for provisional commission ofadministrative digitalization reform (Digital Agency).

19

Misaki Sumida
Attorney
Nagashima Ohno & Tsunematsu(Kyoto University)

A New Corporate Regulatory Approach in Japan’s Digital Arena
Japan's Act on Improving Transparency and Fairness of Digital Platforms(TFDPA) regulates giant digital platform providers such as Amazon, Apple,
Google, and Meta. Its approach is novel, and it seeks to encourage providers
to voluntarily improve the transparency and fairness of their transactions with
their business users through continuous dialogue with stakeholders andevaluations by the government.
To ensure the act’s effectiveness, it is important to give provide companies
incentives to commit. Thus, the government has begun to publicize the status
and evaluation of cases violating the act.
At the time the law was enacted, many questioned its effectiveness, but in thefirst year of its operation, certain effects have already been seen. This could bea pilot case for corporate regulation, known as co-regulation.
Keywords:
Digital platform, Co-regulation, Corporate crime, Incentive structure

CV:
2015
2017

Kyoto University (LL.B.)
Kyoto University Law School (JD)

2018
2021

Nagashima Ohno & Tsunematsu
Legal Specialist in Digital Economy Division / Digital Market Policy
Office, Ministry of Economy, Trade and Industry (METI)

2023

Nagashima Ohno & Tsunematsu

20

Early Career
Researchers’ Forum

21

Participants List
Name

University

Presentation Title

Ahmed Allam

University of Zurich

Machine learning in genome editing research

Clara Duré

University of ZurichTranslational control in aged epidermal stem cells

David Taborsky

University of ZurichTranslational regulation in early development

Jil Affentranger

University of Zurich

Software under European Copyright Law: Protection and Accessibility in an AI context

Kana Eguchi

Kyoto University

Wearable Sensing System for IoT-Infused Healthcare

Martina Nubie

University of Zurich

Microglia-directed gene therapy

Mizuho Nishio

Kyoto University

Radiology report generation from chest X-ray image using 2-stage deep learning models

Moe Hirosawa

Kyoto University

Designing a new Genome Editing Tool

Moeko Okada

University of Zurich

Adaptation of wheat to the Asian environment and changes in food culture

Morteza Rohanian

University of ZurichSupporting Clinical Oncology with Natural Language Processing

Naoto-Benjamin Hamaya

University of Zurich

Understanding the evolutionary genetics behind pollen number and disease resistancein wheat

Nie Jilu

Kyoto University

Exploring the wheat recombination landscape through physical and genetic mapping

Ruth Röck

University of Zurich

Creating kidney cells by direct reprogramming

Shunsuke Yoshioka

Kyoto University

A high-throughput phenotyping of wheat and modeling using the growth data

Valerie Leandra Brunner

University of ZurichComputer-implemented Inventions under European Patent Law: Protection forcomputer simulations?

Yuma Tomizawa

Kyoto University

Pelvic morphology in primates*Alphabetical Order

22

Data Science
andNatural Science23

Kentaro Shimizu
Professor, Co-Director of the University Research Priority
Program of Evolution in Action
Vice-Director of the Department of Evolutionary Biology
and Environmental Studies, Faculty of Science
University of Zurich

Toward the second "green revolution" by connecting Switzerland
and Japan: genome data and machine learning of polyploid wheat
The green revolution in the mid-20th century exploited the semi-dwarfism of aJapanese wheat cultivar and increased world food production (Norman
Borlaug, Nobel Peace Prize 1970). Recent climate change and the war in
Ukraine have highlighted the critical importance of wheat production in broad
geographic regions to guarantee food security. Genome analysis of breadwheat has been difficult due to the large genome size (>5 times larger than ahuman being) and its hybrid polyploid origin. In collaboration with the Wheat
10+ Genomes Project, we reported a genome assembly of the representative
Japanese cultivar Norin 61 using recent advances in data science.
Furthermore, we developed "PlantServation" to analyze images in naturally
fluctuating environments using deep learning. The integration of large genomic
and trait data will pave the way for the "second green revolution" by exploiting
unique East Asian variants to cope with rapid climate changes.
The Japanese grant "International Leading Research" (2022-2030) wasawarded to plant reproduction (Univ. Zurich, Univ. Tokyo, Kyoto Univ., andothers). It will enhance our study through the exchange of young researchers.
Keywords: genome data, machine learning, image analysis, genome duplication
CV:
1997 BS (Biology), Kyoto University, Kyoto, Japan
2002 PhD (Biology), Kyoto University, Kyoto, Japan
2003 Research scholar at the North Carolina State University
2006 Assistant (2006), Associate (2011), and Full Professor (2019-), University of Zurich2015 Visiting Professor at the Center for Ecological Research, Kyoto U. (Sabbatical)
2016 Director of the PhD Program in Evolutionary Biology

24Shuhei Nasuda
Professor
Graduate school of Agriculture / Division of Agronomy
and Horticultural Science
Kyoto University

Towards data-driven breeding - combining genomics and highthroughput phenotyping
The pan-genomes of wheat allow genome-wide surveys of genetic diversity, whichgave way to associating allelic variations with phenotypes. Diverse methods are now
available to evaluate the genetic variation in the genetic resources, and in wheat it
leads to direct application of these resources to breeding programs. Of them, highthroughput phenotyping methods are key technology to address the challenges ofaccurate, precise, and large-scale measurements of plant performance. Soon, we will
be able to design wheat by accumulation of favorable alleles, which will result in thebreeding of wheat cultivars that are environmentally robust, with lower risk to humanhealth.

Keywords:
genomics-assisted breeding, healthy food, polyploid, wheat

CV:
Education
PhD in Genetics, Kansas State University, Kansas, USA (1999)
MS in Agricultural Biology, Kyoto University, Kyoto, Japan (1992)
BS in Agricultural Biology, Kyoto University, Kyoto, Japan (1990)
Employment history
Kyoto University, Laboratory of Plant Breeding, Graduate School of
Agriculture, Professor (2020–present)
Kyoto University, Laboratory of Plant Genetics, Graduate School of
Agriculture, Associate Professor (2014–2020)
Kyoto University, Laboratory of Plant Genetics, Graduate School of
Agriculture, Assistant Professor (1996–2014)
Head of National BioResource Project-Wheat, MEXT, Japan (2012–2020)

25

Michael Krauthammer
Professor
Department of Quantitative Biomedicine
University of Zurich

AI in clinical medicine
The talk will review our recent work on using AI in medical research, including AIassisted diagnosis and decision making, as well as AI-guided design of base andprime editors in the context of finding cures for human genetic diseases.
Keywords:
AI, diagnosis, medical decision making, genome editors, genetic diseases
CV:
My career spans across both medicine and informatics: After receiving an MD degree atthe University of Zurich, Switzerland, I obtained a PhD in biomedical informatics atColumbia University in New York. I then joined Yale University School of Medicine where I
led a research team working on Big Data projects in genetics. Back in Zurich (since 2018),
I established a group in medical informatics with a particular focus on clinical data scienceand translational bioinformatics.
During my informatics career, I worked on various data science projects, including the
GeneWays molecular interaction mining system and the Yale Image Finder platform for
figure-centric literature navigation. My bioinformatics work led to the identification ofimportant driver mutations in skin cancer (melanoma), a key development in theestablishment of melanoma precision medicine.
Current data science projects involve the use of machine and deep learning for theprediction of hospital readmission, drug side effects and base editing outcomes (for basespecific editing of nucleotide sequences using CRISPR and similar tools). A further
emphasis is on the use of AI for Natural Language Processing in the health domain. Our
bioinformatics focus is on single cell analysis in skin cancer and the development of highsensitivity tests for early disease detection and disease monitoring.

26

Koji Fujimoto
Program-Specific Associate Professor
Real World Data Research and Development
Graduate School of Medicine
Kyoto University

Data Science in Diagnostic Radiology
Diagnostic Radiology is a medical discipline concerning the interpretation ofimages obtained by medical devices (e.g., CT, MRI) such that appropriate
decisions can be made for patients. We radiologists “read” medical images,
extract information, and describe possible interpretations of identified
abnormalities. Recent progress in artificial intelligence (AI) has opened various
opportunities to make use of AI images and text in diagnostic radiology. This
presentation introduces several approaches to organizing datasets andappropriately extracting information using recent AI technologies.

Keywords:
diagnostic radiology, deep learning, data scienceCV:

Apr 2020 – present
Associate Professor, Real World Data Research andDevelopment, Graduate School of Medicine, Kyoto University
Feb 2017 – Mar 2020 Assistant Professor, Human Brain Research Center,
Graduate School of Medicine, Kyoto University
Apr 2015 – Jan 2017 Visiting researcher, New York University Langone
Medical CenterApr 2010 – Mar 2015 Assistant Professor, Graduate School of Medicine,
Kyoto University 
Nov. 2010
PhD (Medicine) 
Apr 2006 – Mar 2010 Graduate School of Medicine, Kyoto University27

Kerstin Noëlle Vokinger
Professor
Faculty of Law and Faculty of Medicine
University of Zurich

Regulation of Artificial Intelligence in Medicine
Artificial intelligence (AI) technologies are being increasingly introduced inclinical practice, and the number of cleared medical AI devices has increased
over the past years. These new technologies offer opportunities for improving
patient care but also have risks that need to be addressed. Policymakers andlegislators in different countries have introduced regulations on AI. The
regulation of AI is a balancing act between ensuring safety and fundamental
rights on the one side and driving innovation on the other side.

Keywords:
Artificial intelligence, medicine, medical devices, regulation.
CV:
Current academic positions
2022 - present
2020 - present
2019 - present
2019 - present

University of Zurich, Faculty of Law and Faculty of Medicine
Professor of Law, Medicine and Technology
Harvard University
Faculty Associate, Berkman Klein Center
Harvard Medical School
Affiliated Faculty (Program on Regulation, Therapeutics and Law)
Advising governments and international organizations in areas ofexpertise

Previous academic and professional positions
2019 - 2022
2016 - 2018

University of Zurich, Faculty of Law
Assistant Professor of Public Law Digitalization
Harvard Medical School
Postdoc Fellow (Program on Regulation, Therapeutics and Law)28

2016 - 20172010 - 2015

Harvard Law School
Visiting Researcher (Prof. Dr. Urs Gasser)
University of Zurich, Faculty of Law
Research Assistant (Prof. Dr. Thomas Gächter)

Further positions: Internships in hospitals (e.g., Memorial Sloan-Kettering Cancer Center,
New York) and legal internships in law firms
Education
2021
2015 - 20172015 - 20162012 - 2016
2015
2014
2008 - 20152007 - 2012

University of Zurich, Faculty of Medicine
Habilitation
University of Basel, Faculty of Medicine
Dr. med.
Harvard Law School
LLM (Master of Laws)
University of Zurich, Faculty of Law
PhD (Dr. iur.)
Federal Office for Public Health
Medical Board Examination (Staatsexamen)
Zurich Supreme Court
Bar examination (Anwaltspatent)
University of Zurich, Faculty of Medicine
MD (MMed and BMed)
University of Zurich, Faculty of Law
JD (MLaw and BLaw)

Awards and grants (selection)
2022

2021

Swiss Science Prize Latsis (most prestigious national award forresearchers under 40) awarded for interdisciplinary research inmedicine, law, and technology
Eccellenza Grant - Swiss National Science Foundation (SNSF)

Grants awarded by Swiss National Foundation (SNSF), Krebsforschung Schweiz, Harvard
Law School, Kaiser Permanente Health Policy, and Digital Society Initiative (DSI,
University of Zurich)29