Application Guidebook for Students of General Selection
Graduate School of Medical Sciences
Master’s Degree Program of Major in Medical Sciences
Nagoya City University
for Academic Year 2025（April Enrollment）
Admission policy of Graduate School of Nagoya City University
Nagoya City University (NCU) aims to be a university in which all citizens feel pride and affinity. In graduate
education, based on our recognition that research guidance for graduate students is a challenge in offeringresearch activities. We aim to cultivate researchers and professionals who can gain advanced expertise and aninterdisciplinary thinking.
With this philosophy and aim, the graduate school is widely looking for individuals who possess advanced
expertise and an eagerness and aptitude for activity both within Japan and abroad, in addition to diverse skills andwork experience.

[Master’s Degree Program of Graduate School of Medical Sciences]《Desirable Students》
Individuals who are keenly interested in the most advanced medical science, medical care and life science
Individuals who intend to be a pioneering and creative researcher or a highly-specialized engineer
Individuals who have sufficient academic ability in the basic field of natural science, and are motivated towork at study and research proactively and autonomously.
《Content and level of knowledge that should have been acquired》
In addition to having acquired university-level knowledge in various fields of natural sciences, applicants are
required to have specialized basic knowledge in life science or related fields. In addition, as reading research
papers in English is necessary during research, applicants are also required to have a sufficient level of reading
comprehension in English.
1. Prescribed enrollments (total of April and October enrollment and special selection on
recommendation)
Major in Medical Sciences
10 students
2. Eligibility of applicants
All applicants must satisfy at least one of the following conditions:(1) A person who has graduated from university or is expected to graduate from university by March, 2025.
(2) A person who has a bachelor’s degree by the National Institution for Academic Degrees and Quality
Enhancement of Higher Education under Article 104 (4) of the School Education Law, or who is expected
to complete that course by the end of March, 2025.
(3) A person who has completed a 16-year course of schooling program outside Japan or is expected tocomplete that course by March, 2025.
(4) A person who has completed a 16-year course of schooling program outside Japan that is provided bycorrespondence education in Japan or is expected to complete that course by March, 2025.
(5) A person who has completed or is expected to complete by March, 2025 a 16-year program of the foreign
educational institution established in Japan based on the educational system of this foreign country. Insuch cases, this the institution should be approved by the Minister of Education, Culture, Sports, Scienceand Technology of Japan.
------------------------------------------------------------------------------------------------------------------------------Contact: Administration Officer, Administration Office, Graduate School of Medical Sciences
Nagoya City University
E-mail : med-daigakuin sec.nagoya-cu.ac.jp Inquiries must be made by email.

-1-(6) A person who has completed or is expected to complete to be awarded a bachelor’s degree by March,2025 a 3-year or more year’s program in the university or other tertiary institution in a foreign country
assured by the government or authorized organization in the original country, or specified by the Ministryof Education, Culture, Sports, Science and Technology of Japan. The program includes thecomprehensive education study provided by the foreign university in tertiary institution in Japan, or the
program provided by the foreign educational institution established in Japan based on the educational
system of the original country. In such cases, the institution should be specified by the Ministry of
Education, Culture, Sports, Science and Technology of Japan.
(7) A person who has completed a specialized training course in an advanced vocational school (it is limited
that the courses have 4 or more years and that the level of courses is designated by the Ministry of
Education, Culture, Sports, Science and Technology of Japan) after the date designated by the Ministry of
Education, Culture, Sports, Science and Technology, or who is expected to complete such a course by theend of March, 2025.
(8) A person who has been approved by the Minister of Education, Culture, Sports, Science and Technologyof Japan.
(9) A person who has been enrolled in university for 3 years or more, or completed a 15-year course ofschooling program outside Japan, and who have acquired the prescribed credits with excellent academic
results that is approved by the Graduate School of Medical Sciences.
(10) A person who has academic ability equivalent to or higher than those who have graduated from university
by individual achievement test conducted by Graduate School of Medical Sciences and will become 22
years or older by March 31, 2025.
※Prior to submitting application documents, please contact the faculty member in charge of the department
where you wish to belong, consult him/her regarding your application, and then indicate the potential
supervisor by email below.
med-daigakuin@sec.nagoya-cu.ac.jp<Email Example>(Title) Master’s Degree Program of Major in Medical Sciences April Enrollment(Text) Full name: First/Middle/Last namePotential Supervisor: Professor’s nameTo contact the faculty member, please refer to the following URL:
https://www.nagoya-cu.ac.jp/med/labo/

3. Screening of Qualification for examination under Category （9） or (10) as described above(1) Application period of “Screening of Qualification for examination”
First exam：June 19 (Wed) – June 26 (Wed), 2024 ※must be reached at the end of period.
Second exam：November 5 (Tue) – November 12 (Tue), 2024 ※must be reached at the end of period.
※The second will be held only if the admission capacity is not reached after the first exam.
(2) Application documents
Applicants who fall under Category (9) or (10) must write in red “application qualification documents enclosed,
Graduate School of Medical Sciences, Master’s Degree Program （April Enrollment）” on the envelope, andsend the following 5 documents (ⅰ) Request for Screening of Eligibility for Examination (prescribed form“M-4” ), (ⅱ)Resumé (prescribed form “M-2”), (ⅲ)Achievement Records (prescribed form “M-5”),(ⅳ)Academic Transcript, and (ⅴ)Diploma (a graduation letter), certificate of completion (expectedcompletion) by registered express mail.
※M-2, M-4 and M-5 forms can be downloaded from the following website.

URL: https://www.nagoya-cu.ac.jp/english/faculty/admissions/med/※Must be sent by post. Delivery in person is not accepted. Applications which cannot be reached by thedesignated date will not be acceptable. (the date printed on the postmark is not accountable.)※If you would like to apply from overseas, please make sure to entrust your application procedure to the proxy
residing in Japan. Application by post directly from overseas will not be accepted. Notifications from NCU will-2-

Send the application documents by mail to:
Admissions Office, Student Affairs Division, Administration Office of Nagoya City University
1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan(3) Results of the screening
The results of the screening will be notified to applicants as early as possible.
Applicants who passed the screening can apply to the examination.

4. Period of application and application procedures(1) Period of application
First exam：July 12 (Fri) – July 19 (Fri), 2024 ※must be reached at the end of period.
Second exam：November 28 (Thu) – December 5 (Thu), 2024 ※must be reached at the end of period.
※The second will be held only if the admission capacity is not reached after the first exam.
(2) Application procedures
・Enclose the application documents, etc. into the A4 sized envelope, stick NCU designated address label
which should be filled in the details and send them by registered express mail.
・Must be sent by post. Delivery in person is not accepted. Applications which cannot be reached by thedesignated date will not be acceptable.
・Applications which cannot be reached by the designated date will not be acceptable. (the date printed on the
postmark is not accountable.)・If you would like to apply from overseas, please make sure to entrust your application procedure to the proxy
residing in Japan. Application by post directly from overseas will not be accepted. Notifications from NCU
will be sent to your proxy’s address.
Once your application documents are accepted, admission card and Test center information will be posted
to applicants before the following dates: First exam; August 1st (Thu) and Second exam: December 18(Wed). If you did not receive by those dates, please contact Administration Office of Graduate School of
Medical Sciences (refer to page1).

5. Graduate Course of International Program to Conjoin Brain Science and Society(1) Along with the adoption by MEXT, this program invites the designated number of international students
from the priority areas designated by MEXT members into the 2-year Master program or the 3-year
Doctoral program, and thorough the lectures, seminars and other academic activities held in English,
educate them to become young researchers who have acquired the global level of brain and mental healtharea. ※Concerning the Graduate School of Medical Sciences, only master course students are
eligible. Doctor course students are not.
(2) A limited number of applicants will be admitted.
(3) Students of this program will be determined through the internal selection from those who have passed
the Master Program entrance exam.
*Students of this program is required to simultaneously satisfy the requirements of both their major in thegraduate school and this program.
*For details, please refer to the application guidelines for this program.
6. Application documents, etc.
Documents, etc.
Description
Application for [Use the prescribed form “M-1”]
admission/
Stick your photograph on the application form. A photograph should be taken within 3months, full-faced, upper body, no caps or hat, no background, full-color and sized 4cm
Photo
Identification
1
×3cm.
card/
Please fill in the address which you are (or a proxy is) certain to be contacted.
Examination
Admission card
Resumé
[Use the prescribed form “M-2”]
2*Note 1
In “Academic Background,” start from admission to university (including the course
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3

4

Academictranscript*Notes 1, 3

Diploma(graduation
letter)*Notes 1, 3

5

Residencecertificate

6Letter of
permission fortakingexamination

7

Examination
fee etc. (30,344
yen)

and the department).
If you have work experience, provide details in “Employment History.”
If you apply under Category (3), (4), (5) (6) or (9) of “2. Eligibility of applicants,” andyou have completed curricula in a foreign country, fill in your education history fromelementary education (equivalent to elementary school) to higher education (equivalent
to university education).
Academic transcript should be prepared by university you are currently enrolled in or
have graduated from.
If you apply under Category (2) or (8) of “2. Eligibility of applicants,” the academictranscript is not required.
If you apply under Category (3), (4), (5) (6) or (9) of “2. Eligibility of applicants,” andyou have completed curricula in a foreign country, submit an original transcript of yourhigher education (equivalent to university) completed in a foreign country. A photocopy
will not be acceptable (*Note 2). These documents must be written in Japanese or
English, or the translated document in either of these languages should be attached. In
this case, however, prepare the translation documents separated from the originaltranscript.
Your diploma should be prepared by the university you are enrolled in or have
graduated from.
If you apply under Category (2) or (8) of “2. Eligibility of applicants,” submit adocument certifying your eligibility.
If you apply under Category (3), (4), (5) (6) or (9) of “2. Eligibility of applicants,” andyou have completed curricula in a foreign country, submit an original transcript of yourhigher education (equivalent to university) completed in a foreign country. A photocopy
of your transcript will not be acceptable. (*Note 2). These documents must be written in
Japanese or English, or the translated document in either of these languages should be
attached. In this case, however, prepare the translation documents separated from theoriginal transcript.
If you are a foreign national and eligible for residence in Japan, residence certificate isrequired to submit.
If your visa status is for short-term residence, submit a photocopy of the Japan entry
visa stamped on your passport.
If you are residing in a foreign country, submit a photocopy of your passport.
※Residence certificate without the“Social Security and Tax Number System” isacceptable. If the number is printed on the certificate, please make sure to make it
invisible by using a permanent black pen.
[Use the prescribed form “M-3”]
If you are in employment and wish to be admitted while remaining employed, submit
the examination permission issued by the superior from your workplace.
【Paying the examination fee in Japan】
When paying the examination fee, fill in the transfer request form (prescribed form of
NCU) with the required information, and present it with 30,344 yen (30,000yen for
Examination fee＋344yen for Express mail fee for the admission card to be sent) atbank, etc. for transfer. (Yucho Bank does not accept this transfer. Do not use an ATM,
etc.; use only a teller service.)
The relevant bank fees are to be paid by the applicant.
Submit the “Examination Fee Payment Certificate (Slip B)” received from the bank,etc., together with the other application documents. (Do not submit the “Receipt ofTransfer Amount (and Transfer Fee) (Slip A),” which should be retained by you.)
The examination fee is not normally refundable. However, under a few circumstances,the paid examination fee may be refunded. Confirm this on the NCU website.
・ The examination fee was transferred twice.
・ The application documents were not submitted after the examination fee has beentransferred (or the application was not accepted).
【Paying the examination fee from overseas】-4-

Transfer application fees of 30,344 yen (30,000yen for Examination fee＋344yen for
Express mail fee for the admission card to be sent) to the following accounts by July
19 (Fri) 2024 for the First exam and by December 5 (Thu) 2024 for the Second exam,and submit a copy of the foreign remittance request form.
Type of Transfer: Electronic Transfer
Bank Transfer Fees: Paid by the remitter
Amount of Transfer : 30,344 yen (JPY) ＋all fees associated with the transfer
1) The remitter should pay “Japanese bank fees,” “remitter’s bank fees,” and allfees associated with the transfer.
2) If you transfer money in foreign currency, your application will not be accepted.
Purpose of Transfer: Application fees
[Application Fields]
Bank Name: The Bank of Mitsubishi UFJ, LTD
Bank Branch: Takiko Branch
Account Number: 1232518
Beneficiary Name: Nagoya City University
Address: 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya-shi, Aichi 467-8601 JAPANCurrency: JPY
Swift Code: BOTKJPJT[Use the prescribed form of NCU]
Mailing label
The mailing label will be used to announce the examination result to the applicants.
NCU Address Filled in the details on the designated address label and stick it onto the A4sizedlabelenvelop to be sent to the Entrance Examination and Public Relations Division.

8
9

If you have taken the screening of qualification for examination, it is not necessary to submit theapplication documents 2, 3 and 4 when you apply.
Note2: If any of your “Diploma,” “Academic Transcript” and other certificates issued by a higher educational
institution in a foreign country cannot be reissued, a photocopy is acceptable. If a photocopy is
submitted, the original certificates must be presented at the administration office, Entrance Examination
and Public Relations Division when you come for the admission procedure.
Note 3: If the name written on your “Academic Transcript,” “Diploma” or other certificates is different fromyour current name, provide the document to prove that your name has been changed (e.g., family
register).
Note 4: M-2 and M-3 forms can be downloaded from the following website.
URL: https://www.nagoya-cu.ac.jp/english/faculty/admissions/med/
Note1:

7. Prior consultation of applicants with a physical disability
Applicants (to the degree as determined by Article 22-3 of the School Education Act), who need special
assistance during the examination or with their graduate studies should contact the administrator, Office ofMedical School, NCU by e-mail (refer to page 2).
8. Date and method of selection for admission
Examination dateExamination time【First exam】
August 6 (Tue), 2024

Examination subject

Examination place

10:00－12:00

English (Written test.
Dictionaries may bepermitted except
electronic one.

13:00－14:30

Basic science (Written
test. Japanese or English
proficiency is required.)

15:00－

Interview

Lecture Room B,
11th floor, Medical
School Research
Building
Lecture Room B,
11th floor, Medical
School Research
Building
Details will bepresented on the day-5-

of the examination
Examination date

【Second exam】
January 15 (Wed), 2025

Examination time

Examination subject

Examination place

10:00－12:00

English (Written test.
Dictionaries may bepermitted except
electronic one.

13:00－14:30

Basic science (Written
test. Japanese or English
proficiency is required.)

15:00－

Interview

Lecture Room B,
11th floor, Medical
School Research
Building
Lecture Room B,
11th floor, Medical
School Research
Building
Details will bepresented on the dayof the examination※Examinees receiving the English examination and basic science examination should meet at the examination
place 10 minutes prior to the start time of each examination.
※The second will be held only if the admission capacity is not reached after the first exam.

9. Results of examination:
First exam：September 2 (Mon), 2024 at 14:00
Second exam：February 7 (Fri), 2025 at 14:00
The results of the examination will be announced on the bulletin board on the 1st floor of the Medical School
Research Building of NCU, and also posted to each applicant. (Please contact Administration Office ofGraduate School of Medical Sciences (refer to P.1), if the result won’t be delivered even one week after theannouncement day.)
10. Admission procedure(1) Time period of procedure:First exam：September, 2024
Second exam：March, 2025
Further details will be announced later.
(2) Details of procedure
The details of the procedure will be notified to you together with the results of the examination.
(3) Fees payable during the admission procedurea. Admission fee
Nagoya City residents, etc.
Othersb. Disaster and accident insurance for student education and research

232,000 yen
332,000 yen
1,750 yen

Note 1: The admission fee should be paid through a financial institution before commencing theadmission procedure. Paid admission fee is not refundable.
Note 2: “Nagoya City residents, etc.” means ‘enrolled students’ or ‘those whose spouse or first-degree
family member can prove that his/her continuous residential period in Nagoya city is at least one
year before the date of admission by his/her resident certificate’.
Note 3: Amount of the above tuition fee is example of year 2024. Any revisions to the fees uponadmission shall become effective immediately.

11. Tuition
Annual amount
535,800 yen (267,900 yen per semester for 1st and 2nd semesters)
Note 1: After admission, tuition is to be paid twice a year (for the 1st semester and the 2nd semester)(automatic withdrawal from your account).
Note 2: Amount of the above tuition fee is example of year 2024. Any revisions to the tuition during
enrollment shall become effective immediately.
Note 3: Graduate School of Medical Sciences may charge additional cost without any advance
notification.

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12．A waivers of tuition
Students who can hardly afford the tuition fees with financial reasons and who are recognized to beachieving excellent results in their academic work can apply for a waiver of either full, half, or a quarter of
their tuition fees.
13. Scholarship system
Scholarships of the Japanese Student Services Organization (JASSO) are available to graduate students.
Students wishing to apply to the programs will be referred following a review of academic achievement,
research ability, etc., to determine eligibility.
Ryo Tanaka Incentive Scholarship: Graduate School of Medical Sciences will grant an annual scholarship of
300,000 yen per person to a small number of excellent students.
14. Cautions(1) Applications lacking necessary documents will not be accepted.
(2) Applications found to have made false statements in their applications may have their admission revokedeven after their enrollment.
(3) Application documents, etc. will not be returned.
(4) If your return address has been changed, notify this immediately to the Administration officer, Graduate
School of Medical Sciences, NCU by e-mail (refer to page 1).
(5) Because the coursework is basically conducted in Japanese, applicants must have sufficient Japaneseability, however, a limited number of classes conducted in English is also available.
(6) A double enrollment is prohibited under the rule.
15. Treatment of your personal information
NCU treats your personal information in accordance with the Act on the Protection of Personal Information of
Nagoya City.
(1) Use of your personal informationa. Your name, address and other personal information given in application documents, etc. are used forour operations of selection for admission (e.g., application registration, selection, application result
announcement, admission procedure).
b. Your personal information used for selection for admission (e.g., academic transcript) may be used as
reference material for investigative research and academic research to improve future selection foradmission and graduate education. (Investigative research results are announced in such a way that
individuals cannot be identified.)c. After you are admitted, your personal information is used for operations related to educational affairs(e.g., enrollment management, schooling guidance), student support (e.g., health control, tuition
waiver, application for scholarship, job placement support), and tuition collection.
(2) Entrustment of operations to external business operators
The operations of (1) above may be entrusted to some external business operators under an agreementwith them for proper treatment of personal information.
16. Notifications from NCU in case of emergency
In case of emergency (e.g., occurrence of disaster) or if changes are required to the contents of this application
guidebook, students will be notified those changes through the website of NCU. With those reasons, please
make sure to check the website, especially the examination date comes closer. Applicants may also be directly
contacted. In your application documents, therefore, be sure to provide contact details where you can always
be reached.
○NCU Website
https://www.nagoya-cu.ac.jp/
17. Smoke free campus
NCU hold the smoke free policy on campus. All students are required to follow this policy, and asked tofurther cooperate to avoid smoking on roads and alleys around university campuses.

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Specialized field of study

Research contents

Faculty member in charge
Integrative Anatomy
Prof. Takatoshi Ueki
Anatomy and Neuroscience

Prof. Shinya Ugawa
Biochemistry(TBA)
Cell Biology
Prof. Yoichi Kato
Cell Physiology

Prof. Hikaru Hashitani
Neurophysiology and Brain
ScienceProf. Hideki Hida

(1) Neurobiology to study molecular machinery underlying rewiring of neural circuitry during the brain
development, especially focusing on the physiology of neuron-glia interaction.
(2) Neuroendocrinological studies to elucidate molecular basis of the functional maturation of brain-gut
circuitry, and its involvement in pathophysiology of mental and neurological disorders.
Our current projects are focused on:(1) trying to understand how auditory hair cells convert sounds such as speech and music into electrical signalsthat the brain can interpret(2) trying to understand how newborn neurons in the adult hippocampus are integrated into functional circuitsof the existing network
Our lab consists of highly talented individuals with expertise in microscopy, molecular biology andelectrophysiology needed to efficiently advance our research.
(TBA)
Cilia are antenna-like organelles which are outgrowths of the plasma membrane of eukaryoitc cells. They are
known to be related to a wide rage of diseases. We focus on the following subjects; (1) Elucidating themechanism of ciliogenesis (2) Understanding the regulatory mechanism of signal pathways by cilia (3)Dissecting the pathogenesis of ciliopathies (4) Discovering the roles of cilia in various diseases
Investigations into the functional and morphological characteristics of smooth muscle cells and theirneighbouring cells.
(1) Generation and propagation of spontaneous activity in smooth muscle.
(2) Neurohumoral regulation of smooth muscle function.
(3) Intrinsic properties of microvasculature in visceral organs.
Major techniques employed: electrophysiology, intracellular calcium imaging and fluorescentimmunohistochemistry.
Neuroscience & neurophysiological techniques are used to know physiological brain function through threeprojects with pathophysiological analyses. 1) the mechanism of forelimb function recovery after intracerebral
hemorrhage by rehabilitation 2) the mechanism of function recovery by stem cell (ES / iPS cell) transplantation
in a model of neonatal white matter injury 3) the mechanism in the formation of emotion by gut-brain
interaction that is activated by umami ingestion

Molecular biology for urolithiasis, endoscopic urology, prostate cancer and bone metastasis, thermotherapy for
urological cancer, male infertility and reproductive urology, space urology, technological development for
urological surgery, bimolecular science for urology, genetic therapy, development for voiding function,
Prof. Takahiro Yasui
epigenetic mechanism for urological disease, congenital urological basic research, Robotics, VR technology.
Research Description: We principally employ cell culture and genetically engineered rat models to understandExperimental Pathology and the molecular characteristics of prostate cancers, and to explore their potential as chemopreventive targets.
Alternatively, the following themes are studied in subgroups.
Tumor Biology
・Clinicopathological analysis for development and progression of prostate, breast, and female gynecologic
tumor
・The potential of a gap junctional protein in experimental and human patocarcinogenesis
Prof. Satoru Takahashi
・Discovery of modifying effects against carcinogenesis and their molecular mechanisms by natural products
and compounds including health food products
Pathology and MolecularDiagnostics(TBA)
Nephro-urology(TBA)

Pharmacology
Prof. Susumu Ohya

1. Pathophysiological roles of ion channels in inflammatory diseases
2. Role of ion channels in cancer and immunosuppressive cells under tumor microenvironment (cancer
therapy resistance, cancer stemness, and recruitment of immunosuppressive cells by chemokines)
3. Regulation of ion channels and their regulators in osteoblast differentiation and bone-related diseases
4. Molecular mechanisms of mechanotransduction in cardiac physiology and pathology-8-Specialized field of study

Research contents

Faculty member in charge
Bacteriology
Prof. Tadao Hasegawa
Immunology
Prof. Sayuri Yamazaki
Virology
Prof. Yusuke Okuno
Comparative andExperimental Medicine
Prof. Hisashi Oishi
Rehabilitation Medicine
Prof. Yoshino Ueki
Psychiatry and CognitiveBehavioral Medicine

Prof. Tatsuo Akechi
Obstetrics and Gynecology
Prof. Mayumi Sugiura
Pediatrics and Neonatology
Prof. Shinji Saitoh
Neurocognitive Science
Prof. Takashi Saito

Neuro-Oncology

Prof. Daisuke Kawauchi

Pathogenesis of virulent bacteria, such as group A streptococcus (Streptococcus pyogenes )Analysis of the function and the expression of virulence-associated proteins of bacteria
Development of novel strategies for the treatment of severe bacterial infectious diseases(1) Immune regulation using dendritic cells and regulatory T cells(2) Cell based immune therapy using (1)(3) Inducing effective immune responses by breaking immune tolerance(4) Developing new molecular targeted immune therapy
1. Comprehensive genetic analysis of Epstein-Barr virus (EBV)-associated diseases
2. Comprehensive genetic analysis of rare cancers and inherited diseases
3. Genetic diagnosis of patients with undiagnosed diseases
4. Comprehensive detection of pathogens using next-generation sequencing
We are working on the following subjects through the generating genome-editing animals and the phenotypic
analysess; (1) The effect of membranous proteins recycling pathway on the early development of mammals, (2)Improvement of pregnancy rate by homeostatic and epigenetic analyses of reproductive aging.
① The evaluation of motor and cognitive function using non-invasive methods and creating newneurorehabilitation based on the personalized functional disability ②Creating a novel personalized
rehabilitation system after total hip arthroplasty using wearable cyborg ③ Creating new gait rehabilitation inparkinsonian syndrom using closed loop stimulation ④ prediction and adjust the appropriate rehabilitation ⑤
A Nationwide Survey on the current state of rehabilitation of neurodegenerative disorders
Development of novel treatment using cognitive behavioral therapy, interpersonal therapy, and digitaltechnology for mood disorders, anxiety disorders, post-traumatic stress disorder, eating disorders, and cancer
patients. Research on family intervention and family psychoeducation for mood disorders and schizophrenia.
Development of intervention for developmental disabilities, truant children, and their families. Research on
treatment optimization for refractory depression (mECT, TMS, etc.). Research in the areas of consultation
liaison psychiatry including perinatal care, psycho-oncology, palliative medicine, epileptology, student mental
health, and community mental health s also being conducted.
Recurrent pregnancy loss, preimplantation genetic diagnosis; prenatal diagnosis and fetal therapy; assisted
reproduction technology; genital tumor development mechanism; genetic counselling; Birth cohort of the Japan
Environment and Children's study.
Pathogenesis and treatment of neonatal brain injury, diagnosis and treatment of pediatric endocrinologicaldisorders, Comprehensive management of congenital heart diseases, diagnosis and treatment of pediatricmalignancy, pathogenesis of pediatric liver diseases, pathogenesis of pediatric neurological disorders, genomic
medicine in pediatrics, pediatric application of regenerative medicine, evaluation and management ofdevelopmental disabilities.
Our final goal is to elucidate molecular mechanisms underlying pathogenesis of neurocognitive disorders,
particularly Alzheimer’s disease (AD) and related disorders, and to develop preventive or therapeutic strategies
for the disease. (1) elucidation of the role of chronic neuroinflammation (neuro-glial interaction) associating
disease development (2) understanding of the brain-peripheral interaction for pathogenesis of AD (3)understanding of the disease-disease interaction for acceleration of AD pathogenesis.
Our research aims to elucidate the mechanisms underlying the initiation and progression of brain tumors inboth children and adults, and to identify new therapeutic target molecules based on these findings. We areparticularly focused on developing spontaneously occurring brain tumor mouse models that recapitulate humandisease, and are working to uncover new cancer signals from a unique perspective that integrates
developmental neurobiology, tumor biology, and genome functional studies. Additionally, throughpharmacological experiments using models with transplanted tumors from human patients, we are advancing
research that bridges basic and clinical studies, in collaboration with international partners.

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Specialized field of study

Research contents

Faculty member in charge
Neurodevelopmental
Disorder Genetics
Prof. Kazuhiro Yamakawa

Neurotoxicology

Prof. Masumi Suzui
Developmental andRegenerative Neurobiology
Prof. Kazunobu Sawamoto
Cognitive Function andPathology *Endowed course
Prof. Hiroshi Nomura
Respiratory Medicine,
Allergy and Clinical
Immunology

Prof. Akio Niimi

Cardioangiology
Prof. Yoshihiro Seo
Nephrology

Prof. Takayuki Hamano

Hematology & Oncology

Prof. Shinsuke Iida

It has been revealed that genetic background largely contributes to the pathogenesis of developmental
disorders, and many responsible genes have been identified. Our group has been studying molecular genetics ofneurodevelopmental disorders, intellectual disabilities and epilepsy by identification of responsible genes andanalyses of model mice. we are now trying to develop therapeutic approaches including gene therapies.
(1) Development of a screening method of potential carcinogens by using in silico toxicogenomics, risk
assessment of xenobiotics in foods and occupational or environmental exposure, development of a biomarker
that predicts adverse side effects of medical drugs; (2) Molecular design and generation of a new antitumor
drug aiming at toxicity mitigation, in silico analysis of its anticancer activity and activity analysis by using thewet system; (3) Development of an animal model that is highly sensitive to carcinogenesis by using transgenic
technology, analysis of molecular mechanism of carcinogenesis, evaluation of extrapolative efficacy of theanimal models to humans, development of a diagnostic biomarker of cancer; （4）Studies on the intercellularinteractions via exosomes; (5) Functional analysis of the intracerebral signal peptide
Our lab is interested in new neurons generated by neural stem cells in the adult brain. We are studying themechanisms for neuronal migration, maturation and survival in the physiological and pathological conditions
using a variety of in vitro and in vivo systems. We are also developing technologies to promote migration andregeneration of brain cells.
1. Elucidation of neural mechanisms of learning and memory and emotion. Analysis of neural networks bymeasurement and manipulation of neural activity in vivo and selective visualization of neural circuits.
2. Elucidation of the pathophysiology of neurological and psychiatric disorders related to disruption of memory
and emotion. Development of novel therapeutic and preventive methods for these disorders.
・Chronic airway deceases (asthma, chronic cough, COPD and chronic airways infection): epidemiology,
disease concept, pathophysiology, genetic determinants, CT image analysis, diagnosis and treatment.
・Lung cancer: molecular pathobiology, susceptibility to anticancer agents,and multicenter large-scale studies.
・Respiratory infection（nontuberculous mycobacteriosis, pneumonia）:
epidemiology, pathophysiology, CT image analysis, diagnosis and treatment.
・Interstitial lung diseases: pathophysiology, CT image analysis and treatment.
・Relationship of respiratory symptoms such as cough and gastroesophageal reflux disease.
・Connective tissue disorders: search of novel autoimmune molecules, pathophysiology analysis and diagnosis
using clinical samples, and treatment.
Development and clinical application of advanced echocardiography; 1. Development of a 4D speckle tracking
method to evaluate cardiac function and myocardial properties, 2. Development of a renal circulation imaging
method in heart failure, 3. Development of a new stress echocardiography method and its application to heart
failure diagnosis, 4. Development of a method to evaluate early myocardial damage in oncocardimyopathy.
1. Complications of chronic kidney disease, especially renal anemia andmineral bone disorders
2. Research on diabetic kidney disease and congestive kidney focusing on
the kidney size
3. Research on acute kidney injury
4. Research on pathophysiology of cardiorenal syndrome
1. Dissection of molecular pathogenesis of hematopoietic neoplasms, identification of novel molecular targets,
exploration of biomarkers predicting for the efficacy and adverse events of molecular targeting therapies, andmechanisms responsible for the drug resistance
2. Development of novel immune therapies against cancer with therapeutic antibodies or chimeric antigen
receptor T-cell (CAR-T) therapies
3. Planning and conducting preclinical studies and clinical trials against cancer-10-Specialized field of study

Research contents

Faculty member in charge

1. Elucidation of the mechanisms of neurocognitive dysfunction in the perioperative period
Anesthesiology and Intensive 2. Elucidation of the pathogenesis of central nervous system disorders caused by sepsis and development ofCare Medicine
treatment methods,
Prof. Kazuya Sobue

3. Elucidation of the pathogenesis of chronic pain and development of treatment methods
4. Elucidation of the mechanisms of chronic pain in the oral region and development of treatment methods
5. Basic research on nutritional management for critically ill patients
6. Clinical research in the areas of anesthesia and intensive care

Quantitative and qualitative research on the following topics. 1.Training of general practitioners/internal
General Medicine & General medicine physicians (curriculum development, video review, interdisciplinary collaboration, etc.) 2.Promotion
Internal Medicine
of ACP (Advance Care Planning) 3.The usefulness of medical interviews (training of standardized patients,
Prof. Kei Miyazaki

Clinical Pharmaceutics
Prof. Yoko Hibi
Advancing Acute Medicine
Prof. Hiroshi SasanoProf. Tomonori Hattori
Department of Emergency
and Critical Care
Prof. Asako Matsushima
Occupational andEnvironmental HealthProf. Michihiro Kamijima
Public HealthProf. Sadao Suzuki
Forensic Medicine(TBA)
Medical Education
Prof. Osamu Takakuwa
Medical Innovation
Prof. Takeshi Kamiyaetc.) 4.SDH (Social Determinants of Health) (COVID-19, medical access for foreign residents in Japan, etc.)
5.Development of a new concept of health (positive health) 6.National survey, diagnosis, and development oftreatment methods for rare diseases (SCLS etc) 7.Community-based participatory research utilizing community
health care centers (such as frailty prevention)
1. Analysis of risk factor of side effect on chemotherapy.
2. Efficacy evaluation of new therapeutic drug monitoring software of antibacterial agents.
3. Analysis of the relationship between urinary / kidney diseases and drugs and development of new treatments.
4. Clinical research based on drug treatment issues, etc.
（Prof. Hiroshi Sasano） Breathing-circulation cooperation (heart rate, blood flow variability analysis,
physiology of respiratory sinus arrhythmia), the development of clinical devices (ultrasound-guided puncture,oxygen administration), peripherally inserted central venous catheter, medical simulation education.
（Prof. Tomonori Hattori）Venous blood gas and lactate studies, Research on sepsis pathology andendothelial-derived hyperpolarizing factor (EDHF), Research on frailty and emergency medicine, Research onlung damage caused by COVID-19, Research on Long COVID-19
Clinical study of sepsis and infection control.
Clinical study of trauma and critical care.
Study of disaster reduction and medicine
Stusy of helthcare art at emergency room(1) Risk assessment of environmental chemicals (research on their health effects, mechanisms of action,
exposure characterization), (2) Epidemiologic study on children's environmental health
The department specializes in epidemiology. The target outcome includes lifestyle-related diseases such as
cancer, diabetes mellitus, and metabolic syndrome, QOL, health status, and death. Using a statistical approach,
we discuss the relationship between these outcome and genetic and/or environmental factors such as life styles,
psychosocial factors, and genetic polymorphism including the interaction. We also work on evaluation andcomparison of diagnostic tests, clinical epidemiology and descriptive epidemiology of intractable diseases.
(TBA)

Development of medical and healthcare education systems among multiple medical institutes. Development ofeffective faculty developments for clinicians. Development and assessment for new interprofessional education
system.
1. Pathophysiology, epidemiology and new therapeutic strategies of functional gastrointestinal disorders 2.
Methodiology and pedagogy of clinical studies 3. Basic studies on the mechanisms of visceral perception 4.
Database studies on gastrointestinal and circulatory diseases 5. Pathophysiology and new therapeutic strateriesof heart failure 6. Clinical studies of emerging infectious diseases by mathematical models 7. International
studies of prevention and treatment on peuminia and ARDS

-11-Specialized field of study

Research contents

Faculty member in charge

Biostatistics and Health Data Development of new statistical methods in the medical field, research on biostatistical methodologies, data
Sciencescience research as an applied field of statistics (e.g. data management, data collection design, statisticalanalysis, interpretation, and communication methodologies), and research on methodologies related to planning
Prof. Kenichi Yoshimuraand conducting clinical research and trials as an applied field of biostatistics.
（Prof. T. Matsumoto）・Physics between nanomaterials (quantum wires, dots) and near-field
Clinical Medical Design
electromagnetic waves (surface plasmon polariton and evanescent wave), and its application to nanoscalebiomedical engineering.
・Deuterium separation by using nanomaterials and the design of new isotope drugs.
（Prof. A. Morita）Development of medical device utilizing the photobiological specificity of wavelength
Prof. Takahiro Matsumoto
Bridging translational research among medicine, biology and engineering（Prof. T. Ueki）・Application of machine learning for computational anatomy and connectomics, andProf. Akimichi Morita
understanding of the pathophysiology of neurological and psychiatric disorders
・Translational studies on construction of automated diagnostic imaging system based on big data analysis
Prof. Takatoshi Ueki
・Medical technology of drive system of minimally invasive surgery robot（Associate Prof. T. Kato）Design and development of Control methods for medical equipments, Minimally
Prof. Takashi Kato
invasive surgical robots, Preventive medical devices based on human physics & biology, Novel personal
healthcare indexes derived from clinical medicine.
Prof. Dai Hanawa（Associate Prof. D. Hanawa）・Human's biological/activity monitoring system using sensor networks
・Task supporting system using VR/AR/MR techniquesProf. Takaya Terada（Assistant Prof. T. Terada）・Medical engineering・Application of laser and optical technology・Medical
device development-12-