DATA SHEETHyPerforma Rocker Bioreactor

HyPerforma Rocker Bioreactor
The Thermo Scientific™ HyPerforma™ Rocker Bioreactors
bring control and measurement to rocking bioreactor
applications. The rocker is controlled by a Thermo
Scientific™ HyPerforma™ Bioprocess Controllers andThermo Scientific™ Bioprocess Automation and Control
Software, powered by the Emerson™ DeltaV™ Distributed
Control Platform. This provides a complete solution forresearch, process development, or seed train production
applications. The HyPerforma Rocker Bioreactors use
BPCs with working volumes of 5, 10, and 25 L are available
with or without the novel Thermo Scientific™ pH+dO2sensor and reader.
Key features• Compatible with most cell culture applications• Rocking motion is customizable to your specificworkflow—from a smooth waveform that minimizes shear
forces for sensitive cell lines, through four intermediate
steps, to an aggressive motion that maximizes oxygen
transfer for robust cells with high oxygen demands• Quick, simple setup with a HyPerforma Bioprocess
Controller and TruBio software• Optional accessories include rocker cover, tray adapter
for use with 10 L and 20 L BPCs, and sensorless coverplate for when the reader is not being used

• Each HyPerforma Rocker BPC is available in 10, 20,and 50 L (5, 10, and 25 L maximum liquid volume)
sizes and is delivered with all relevant certificates,gamma-irradiated (25 to 40 kGy) and conforming toUSP Class 6 specifications• Standard service packages• cGMP-compliant capabilities• Load cell for weight control• The pH+dO2 sensor provides measurement and controlof critical process parameters: pH, dissolved oxygen(DO), and temperature

HyPerforma Rocker BPC sizes

10 L20 L50 L

Rocker BPC dimensions

549.4 x 330.2 mm(21.6 x 13.0 in.)

549.4 x 660.1 mm(21.6 x 26.0 in.)

711.2 x 723.9 mm(28.0 x 28.5 in.)Working volume

5L

10 L25 LMinimum working volume

1L

2L

5L

HyPerforma Rocker Bioreactor

Rocker bioreactor assembly, load cell, GMP, stainless steel(includes rocker base, tray base, 50 L tray)

Bag adapter

10 L/20 L BPC mounting adapter for 50 L rocker tray

Vent filter heater

BPC filter heater (quantity: 2)

Dimensions (H x W x D)

264 x 782 x 701 mm (10.4 x 30.8 x 27.6 in.);
490 x 835 x 712 mm (19.3 x 32.9 x 28.0 in.) with cover

Weight (base + tray)

38.5 kg (85 lb)

Rocking angle

2° to 12° per side

Rocking rate

2 to 40 cycles per minuteElectrical power

110–120 V, 220–240 V, 50/60 Hz, powered by the HyPerform Bioprocess Controllers

Operating temperature

0°C to 45°C (32°F to 158°F)

Storage temperature–40°C to 70°C (–40°F to 158°F)

Humidity

5% to 95%, noncondensing

Acoustic noise level<70 dBA

pH sensor range

pH 5.5 to 8.5

pH sensor relative accuracy±0.1 pH units over calibration range after a 2-point calibration having 0.3 to 0.8 pH
units of separation

DO sensor range (percent saturation)

0% to 250%

DO sensor limit of detection

0.03% O2

DO accuracy

At 25°C: ±1.1% at 20.95% O2

Temperature

10°C to 45°C (50°F to 113°F)

Temperature accuracy±0.15°C at 15°C to 40°C (±0.25°F at 59°F to 104°F)

TruBio Bioprocess Automation and Control Software
The TruBio software provides easy-to-configure process control, eliminating
the need to learn automation control programming. Developed for use withHyPerforma Bioprocess Controllers, TruBio software is designed to support
easy scaling and technology transfer and building of sophisticated processcontrol strategies. It also provides the flexibility to incorporate a wide range ofcell culture, fermentor, or mixing vessels, and manage multiple data streams
from several unit operations. TruBio software is powered by the Emerson DeltaV
system, has been developed according to Good Automated Manufacturing
Practice (GAMP™) 5 methods, and conforms to regulatory requirements for use
in cGMP-compliant processes.
• For non-GMP research and process development applications: Thermo
Scientific™ TruBio™ Discovery Bioprocess Control Software powered by theEmerson™ DeltaV™ Discovery platform• For GMP and typical scale-up to manufacturing applications: TruBio
software powered by the conventional DeltaV platform

Ordering information
HyPerforma Rocker Bioreactors and BPCs

Cat. No.

HyPerforma Rocker Bioreactor, with load cells

F100-2683-001

HyPerforma Rocker Bioreactor, without load cells

F100-2683-002

10 L HyPerforma Rocker BPC, LDPE film, cGMP, with sensor

F100-2544-001

20 L HyPerforma Rocker BPC, LDPE film, cGMP, with sensor

F100-2545-001

50 L HyPerforma Rocker BPC, LDPE film, cGMP, with sensor

F100-2546-001

10 L HyPerforma Rocker BPC, Aegis5-14 film, cGMP, without sensor

SH31187.01

20 L HyPerforma Rocker BPC, Aegis5-14 film, cGMP, without sensor

SH31187.02

50 L HyPerforma Rocker BPC, Aegis5-14 film, cGMP, without sensor

SH31187.03

Find out more at thermofisher.com/rockerbioreactor
For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.
© 2020 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries
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