Bioprocess Division
1-1-2 Yurakucho, Chiyoda-ku, Tokyo 100-0006 Japan
Phone: +81 (0)3-6699-3782 Fax: +81 (0)3-6699-3784

Cover Sheet for Asahi Integrity Test Solutions Kit Safety Data Sheet
The Asahi Integrity Test Solutions Kit is solely for use in the post-use gold particle test (GPT) of
PlanovaTM filters. This Safety Data Sheet for the United States (OSHA HCS1) and the European Union(EU CLP2) covers the following components of the Asahi Integrity Test Solution Kit:
• Asahi Integrity Test Solution (Concentrated)• SDS (Sodium Lauryl Sulfate)

Hazard identification
OSHA HCS1 and EU CLP2 Classifications

Class

Category
Asahi Integrity Test Solution (Concentrated)
Skin corrosion/irritation
Not classified
Serious eye damage/eye irritation
Not classified
SDS (Sodium Lauryl Sulfate)
Acute toxicity(oral)
4

Pictogram

Signal word

Information
for EU CLP2
H codeH302

Acute toxicity(dermal)

3

H311

Skin corrosion/irritation

2

H315

Eye damage/irritation

1

Specific target organ toxicity single
exposure

3 (respiratory tract
irritation)

H335

Specific target organ toxicity
repeated or prolonged exposure

2 (liver)

H373

Hazardous to the aquatic
environment (acute)

1

H400

Danger

H318

Hazard statements
H code
H302
H311
H315
H318
H335
H373
H400

Hazard statement
Harmful if swallowed
Toxic in contact with skin
Causes skin irritation
Causes serious eye damage
May cause respiratory irritation
May cause damage to liver through prolonged or repeated exposure
Very toxic to aquatic life

Precautionary statements for SDS (Sodium Lauryl Sulfate) for EU CLP2
P260: Do not breathe dust/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contactlenses, if present and easy to do. Continue rinsing.
P310: Immediately call a poison center/doctor.
P337+P313: If eye irritation persists: Get medical advice/attention.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
1

OSHA HCS: 29 CFR Part 1910, Federal Register, Vol. 77, No. 58, March 26, 2012
EU CLP: Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008

2

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Safety Data Sheet
Section 1: Identification of the substance/mixture and of the company/undertaking
1.1. Product Identifier
Product/chemical name:
Synonyms:
Product description:
Product code:

Asahi Integrity Test Solution (Concentrated)
AGP-HA15, AGP-HA20 and AGP-HA35
Colloidal gold particle solution
AGP-HA15M, AGP-HA15S, AGP-HA20M, AGP-HA20S
AGP-HA35M, AGP-HA35S

1.2. Relevant uses of product: Solely for the post-use GPT of PlanovaTM filters
1.3.Contact information of Manufacturer/Supplier:Name of manufacturer:
Asahi Kasei Medical Co., Ltd.
Bioprocess Division
1-1-2 Yurakucho, Chiyoda-ku, Tokyo 100-0006 JAPAN
Tel: +81-3-6699-3782; Fax: +81-3-6699-3784
Email address: info.jp@ak-bio.com
Name of supplier (importer) in the EU:
N.V. Asahi Kasei Bioprocess Europe S.A.
Rue Colonel Bourg, 122, 1140 Brussels, Belgium
Tel: +32-2-526-0500; Fax: +32-2-526-0510
Email address: info.eu@ak-bio.com
Name of supplier (importer) in the US:
Asahi Kasei Bioprocess America, Inc.
1855 Elmdale Avenue, Glenview, IL 60026 USA
Tel: +1-847-556-9700; Fax: +1-847-556-9701
Email address: info.us@ak-bio.com
1.4. Emergency telephone number
In case of emergency, call the local poison control center.
Section 2: Hazard identification
2.1. Classification of the mixture
Classification according to OSHA HCS and EU CLP: Not classified
2.2. Label elements:
In accordance with OSHA HCS and EU CLP: Not applicable
2.3. Other hazards:
In accordance with OSHA HCS: No information
In accordance with EU CLP: The solution does not meet the criteria for PBT or vPvB
according to Regulation (EC) No 1907/2006, Annex XIII.
Section 3: Composition/information on ingredients3.1. Mixtures
Product/chemical name: Asahi Integrity Test Solution (Concentrated)

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Asahi Integrity Test Solution (Concentrated)

Information on ingredients:
Chemical name
Sodium lauryl sulfate
Gold
Sodium citrate
Polyvinylpyrrolidone
Chloride ion
Water

Content (wt %)
≤0.5
≤0.05
≤0.2
≤3
≤0.05
≥96.2

CAS No.
151-21-3
7440-57-5
6132-04-3
9003-39-8
7732-18-5

EC No.
205-788-1
231-165-9
200-675-3
231-791-2

Classification of ingredients contributing to EU CLP hazards classifications*:
Sodium lauryl sulfate: Acute toxicity (oral), 4, H302; Acute toxicity (dermal), 3, H311; Skin
corrosion/irritation, 2, H315; Eye damage/irritation, 1, H318; Specific target organ toxicity(single exposure), 3 (respiratory tract), H335; Specific target organ toxicity (repeatedexposure), 2 (liver), H373; Aquatic acute, 1, H400
*Full text of hazard statements is given in Section 16 of this Safety Data Sheet.

Section 4: First-aid measures
4.1. Description of first aid measures
IF INHALED: Remove victim to fresh air and keep warm and at rest in a position comfortablefor breathing. Seek medical attention if in a critical condition.
IF ON SKIN: Remove contaminated clothing including shoes and immediately wash affectedarea with plenty of water. Get immediate medical attention. Wash contaminatedclothing and shoes before reuse or dispose to waste.
IF IN EYES: Immediately flush eyes with plenty of water for two to three minutes. Remove
any contact lenses and continue flushing for at least 15 minutes. Assure adequate
flushing by separating the eyelids with fingers. Seek immediate medical attention.
IF SWALLOWED: Wash out mouth with water. Do not induce vomiting unless instructed by
medical personnel. Seek immediate medical attention.
4.2. Most important symptoms and effects, both acute and delayed
Acute effects: May cause eye irritation
Delayed effects: No information
4.3. Indication of any immediate medical attention and special treatment neededShow this Safety Data Sheet to medical personnel. Give symptomatic treatment andsupportive therapy.
Section 5: Fire-fighting measures
5.1. Extinguishing media
Suitable extinguishing media: Water spray, dry chemical powder, foam, carbon dioxide, or sandUnsuitable extinguishing media: Direct discharge of water jet
5.2. Specific hazards arising from the substance or mixture
If involved in a fire, this product may emit hazardous decomposition and combustion fumes(e.g., sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide, and chlorine
derivatives).
5.3. Advice for firefighters
Firefighters should use full protective gear for surrounding fire.

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Section 6: Accidental release measures
6.1. Personal precautions, protective equipment, and emergency procedures
For non-emergency personnel:
Evacuate, except for responsible personnel.
In case of emergency, contact local authorities and responsible personnel.
For emergency responders:
Wear appropriate personal protective equipment described in Section 8 (exposure
control) to prevent inhalation and contact with eyes and skin.
6.2. Environmental precautions
Prevent leakage of product into waterways or drainage systems by diking with sand or otherabsorbent material.
Contact authorities, water and waste-water treatment plants as appropriate if significant
contamination occurs.
6.3. Methods and materials for containment and cleaning up
Absorb the spill promptly with towels, and clean area with water.
In the event that the product dries, clean it up with water; however, coloration due to gold particles
may remain.
Collect larger spills using techniques such as inert sorbent materials or pumping.
Wash contaminated surfaces with plenty of water.
Follow prescribed procedures for responding to large spills and reporting to appropriate
authorities.
6.4. Reference to other sections
Refer to Section 8 (exposure control) and Section 13 (disposal) as appropriate.
Section 7: Handling and storage
7.1. Precautions for safe handlingContainment and measures for safe handling:
Avoid contact with skin, eyes and clothing. Do not breathe vapors/mist/spray. Keep
container tightly closed when not in use. Contains nanomaterials, and ingredients
which have not been fully tested, so handle with caution.
Store in a sealed container without damage or leakage.
Advice on general occupational hygiene:
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.
7.2. Conditions for safe storage, including any incompatibilities
Store at temperatures between 1 and 30 °C (34 – 86 F).
Refrigeration is not required. Do not freeze.
Avoid storing under high humidity.
Avoid exposure to direct sunlight.
Incompatible materials: Strong oxidizing agents, hypochlorite solution
7.3. Specific end use(s)Integrity test (gold particle test) of Planova filters.

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Section 8: Exposure controls/personal protection
8.1. Control parameters
Occupational Exposure Limits: Not established in the US or EU.
8.2. Exposure controls
Appropriate engineering controls:
Recommended to handle in fume hood, but careful handling may be sufficient for small
quantities of product.
Use only in facilities equipped with a safety shower, and hand and eye washing facilities near
the handling and storage areas. The locations of these safety facilities must be clearlymarked.
8.3. Individual protection measures, such as personal protective equipment:
Respiratory protection: Wear respiratory protective equipment if exposure tovapor/mist/spray is likely. PPE should be to European (EN) or US Standards. Consult
manufacturers concerning breakthrough times.
Skin protection: chemical resistant gloves (e.g., butyl or nitrile rubber) and suitable
protective clothing (e.g., apron, sleeves and boots).
Eye protection: Wear safety goggles.
8.4. Environmental exposure controls:
Take care to not release product into drains, sewers, and streams or other waterways.
Section 9: Physical and chemical properties
9.1. Information on basic physical and chemical properties
Appearance:
Purple colored colloidal solution
Odor:
Odorless
Odor threshold:No information
pH:
Around 5
Melting point:
ca. 0 °C (water)
Boiling point:
ca. 100 °C (water)
Flash point:
Not expected for water-based productEvaporation rate:
No information
Flammability (solid, gas)
Not expected for water-based product
Upper/lower flammability
or explosive limits:
No information
Vapor pressure:ca. 24 mmHg (25 C) (water)
Vapor density
No information
Relative density
No information
Solubility(ies)
No information
Partition coefficient:
n-octanol/water
No information
Auto-ignition temperature
No information
Decomposition temperature No information
Viscosity
No information
Explosive properties
Not expected for water-based productOxidizing properties
No information
9.2. Other information
Particle size:

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Around 18 – 38 nm

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Section 10: Stability and reactivity
10.1. Reactivity:
This product is considered to be a non-reactive material under normal and anticipatedstorage and handling conditions.
10.2. Chemical stability
Stable under recommended storage and usage conditions.
Some substances may cause coagulation and settling of gold colloids.
Aggregation of gold colloids may cause a change in solution color from purple to blue.
10.3. Possibility of hazardous reactions
No information available
10.4. Conditions to avoid
Avoid high temperature and direct sunlight. Do not freeze.
Store between 1 and 30 °C (34 – 86 F).
10.5. Incompatible materials
Strong oxidizing agents, hypochlorite solution
10.6. Hazardous decomposition products
If involved in a fire, this product will emit hazardous decomposition and combustion fumes(e.g., sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide and chlorine
derivatives).
Section 11: Toxicological information
11.1 Information on toxicological effects
Information on mixture:
Skin corrosion/irritation:
Serious eye damage/irritation

May irritate skin and cause deposition of purple-colored gold onskin surface, which is difficult to remove when dried.
May irritate eyes and cause deposition of purple-colored goldon eye surface.

Information on ingredient (sodium lauryl sulfate, 151-21-3):
Acute toxicity (oral):Rat LD50 = 1,200 mg/kg
Acute toxicity (dermal):Rabbit LD50 = ca. 600 mg/kg
Skin corrosion/irritation:
According to results of tests in rabbits, “Severely irritating (PII:7.73)”, and “Moderately to strongly irritating”.
Moderately irritating in humans at a concentration of 20%.
Serious eye damage/
Severely irritating to the eyes of rabbits and caused irreversible
irritation:
corneal effects.
Skin sensitization:
In the OECD SIDS report, it is concluded that alkyl sulfates will
give no concern for skin sensitizing properties based on theavailable data in experimental animals as well as from data inhumans.
Germ cell mutagenicity:(in vitro) Negative in Ames test.
(in vitro) Negative in mouse lymphoma cell forward mutation
assay.
(in vivo) Negative in chromosome aberration assay in rats.
(in vivo) Negative in dominant lethal assay in mice.
Carcinogenicity:
No information
Reproductive toxicity:
No information

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Asahi Integrity Test Solution (Concentrated)

STOT-single exposure:
STOT-repeated exposure:

Aspiration hazard:

Respiratory irritation was observed in mouse, rabbit and guinea
pig those exposed via aerosol.
In a 28-day gavage study with rats, an increase in alanine
aminotransferase (ALT) activity accompanied by an increase of
relative weights of liver was observed. In the OECD SIDS
report, it is concluded that the liver is the only target organ forsystemic toxicity of alkyl sulfates based on results of oral
application tests with chain lengths between C12 and C18.
No information

11.2 Information on the likely routes of exposure
Refer to Section 11.1 (Information on toxicological effects)
11.3 Symptoms related to the physical, chemical and toxicological characteristics
Refer to Section 11.1 (Information on toxicological effects)
11.4 Delayed and immediate effects and also chronic effects from short and long term exposure
Acute effects: May cause eye damage
Delayed effects: No information
11.5 Numerical measures of toxicity
Not applicable
11.6 Interactive effects
No information
11.7 Whether the chemical is listed in the NTP Report on Carcinogens or has been foundto be a potential carcinogen in the IARC Monographs, or by OSHA
IARC: Not listed as Group 1, 2A or 2B
NTP Report: Not listed
OSHA: Not listed
Section 12: Ecological information
12.1. Toxicity:
Information on mixture:

No information

Information on ingredient (sodium lauryl sulfate, 151-21-3):
Aquatic acute toxicity:
Crustacea (Homarus americanus) 96 h LC50 = 0.72 mg/L
Algae (Desmodesmus subcapitata) 72 h ErC50 > 120 mg/L
Algae (Pseudokirchneriella subcapitata) 96 h ErC50 = 117 mg/L
Aquatic chronic toxicity:
Fish (Pimephales promelas) 42 d NOEC > 1.36 mg/L
Crustacea (Ceriodaphnia dibia) 7 d NOEC = 0.88 mg/L
Algae (Desmodesmus subcapitata) 72 h NOEC = 30 mg/L
12.2. Persistence and degradability:
Information on mixture:

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No information

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Asahi Integrity Test Solution (Concentrated)

Information on ingredient (sodium lauryl sulfate, 151-21-3): Rapidly degradable
12.3. Bioaccumulative potential:
Information on mixture:

No information

Information on ingredient (sodium lauryl sulfate, 151-21-3):
Fish (Cyprinus carpio) BCF = 3.9 – 5.3
12.4. Mobility in soil:
No information
12.5. PBT and vPvB in accordance with EU CLP: The solution does not meet the criteria for
PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
12.6. Other adverse effects:
Includes ingredients that may persist in the environment.
Contains nanomaterials and ingredients which have not been fully tested.
Dispose of with care.
Section 13: Disposal considerations
13.1. Waste treatment methods
Do not dispose of via the drains or to landfill.
Recycling is the recommended route of disposal.
Disposal must be in accordance with current national and local regulations.
Chemical residues generally count as special waste, and their disposal may be regulated in
EC member countries through applicable laws and regulations.
We recommend that you contact either the authorities or an approved waste disposal
company for advice on disposal of special waste.
General EU requirements are given in the Waste Framework Directive (75/442/EEC) and theHazardous Waste Directive (91/689/EEC).
Packaging and other wastes may contain residues of the product and should be treatedaccordingly.
Section 14: Transport information
14.1. UN number:
14.2. UN proper shipping name:14.3. Transport hazard class(es):14.4. Packing group:
14.5. Environmental hazards:
14.6. Special precautions for user:

Not applicableNot applicableNot applicableNot applicableNot applicable
Confirm that containers have no leaks before
moving. Protect containers against fall, drop
and physical damage.
14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC code
Not applicable
Section 15: Regulatory information
15.1. Safety, health and environmental regulations specific for the product in question
The product and its ingredients are not regulated by specific provisions related to protection ofhuman health or the environment at EU level, e.g., not considered as SVHCs or POPs.

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EU
REACH Regulation (1907/2006).
Regulation (EC) No 1272/2008 on Classification, Labelling and Packaging of Substances and
Mixtures.
Chemical Agents Directive (98/24/EC).
Personal Protective Equipment (EC Directive) Regulations SI 1992/3139.
BELGIUM
Appendix II of the "Règlement Général pour la Protection du Travail (RGPT)" or "Algemeen
Reglement voor de Arbeidsbescherming (ARAB).
Occupational exposure limits: Valeurs Limites d'Exposition Professionnelle (VLEP); or
Grenswaarden voor Beroepsmatige Blootstelling (GWBB); Annex 1 of the arrêté royal du
11 mars 2002 relatif à la protection de la santé et de la sécurité des travailleurs contre lesrisques liés à des agents chimiques sur le lieu de travail; Ministry of Employment andWork.
FRANCE
Decree of 21 February 1990, définissant les critères de classification et les conditions
d’etiquetage at d’emballage des preparations dangereuses, as amended.
The Control of Chemical Products Act, Law 77-771 of 12 July 1977, sur Ie Controle desProduit Chimiques, as amended.
Valeurs limites d'exposition professionelle aux agents chimiques en Institut National deRecherche et de Sécurité, Document ED 984.
GERMANYThe product is self-classified as WGK 1 on the basis of ingredient information.
Chemicals Act: Gesetz zum Schutz vor gefährlichen Stoffen (Chemikaliengesetz - Chem G).
Dangerous Substances Ordinance: Verordnung zum Schutz vor gefährlichen Stoffen(Gefahrstoffverordnung - GefStoffV).
WGK Regulation: Verwaltungsvorschrift wassergefährdende Stoffe (VwVwS).
Occupational exposure limits: List of MAK and BAT Values 2006, Commission for theInvestigation of Health Hazards of Chemical Compounds in the Work Area, Report No.
42, Wiley-VCH.
UK
Chemical (Hazard Information and Packaging for Supply) Regulations 2009 (SI 2009 No 716)
(CHIP4).
Control of Substances Hazardous to Health Regulations 2002 (COSHH).
Health and Safety at Work Act 1974 c 37.
Workplace Exposure Limits EH40/2005 with 2007 supplement, Health and Safety Executive.
UNITED STATESOSHA: Not hazardous
TSCA inventory: All ingredients in this product are listed on the TSCA Inventory.
TSCA SNUR: Not listed
SARA Title III: Not listed
CERCLA Reportable Quantity: Not listed
Clean Air Act: This product does not contain any substances regulated as hazardous air
pollutants under Section 112 of the Clean Air Act.
Clean Water Act: This product does not contain any substances regulated as pollutants
pursuant to the Clean Water Act.
CALIFORNIA PROPOSITION 65: This product does not contain any chemical substances known
to the State to cause cancer or reproductive toxicity according to the list of March 2015.

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Asahi Integrity Test Solution (Concentrated)

Section 16: Other information
Update history:
Date of first issue:
April 10, 2004
Date of most recent revision: September 3, 2021; Supersedes Version 3.0 issued August 26,
2015
Sections revised: Content changes were made to Sections 7 and 10.
References:
Data of Asahi Kasei Medical Co., Ltd.
OECD SIDS Initial Assessment Report, Category of Alkyl sulfates, Alkane sulfonates and α-olefin
sulfonates (2007)
NITE GHS classification results (2015)
Additional information on nanomaterials:
Hazard data is not available. The following reports provide information on the regulation of
nanomaterials. Consult the regulations in effect in the country of use.
Report on Regulatory Aspects of Nanomaterials (2008/2208(INI)), Committee on theEnvironment, Public Health and Food Safety, European Parliament Rapporteur: Carl
Schlyter
Sixth Session - Forum VI Final Report (IFCS/FORUM-VI/07w), WHO Intergovernmental
Forum on Chemical Safety, Dakar, Senegal, September 15-19, 2008, issued October 10,
2008.
Full text of Hazard statements referred to in Sections 2 and 3:
H302: Harmful if swallowed
H311: Toxic in contact with skin
H315: Causes skin irritation
H318: Causes serious eye damage
H335: May cause respiratory irritation
H373: May cause damage to liver through prolonged or repeated exposure
H400: Very toxic to aquatic life
Abbreviations
BCF: Bioconcentration Factor
CAS No.: Chemical Abstracts Service Registry Number
EC: European Community
ErC50: Median Effect Concentration
LD50: Lethal Dose50
NOEC: No Observed Effect Concentration
OECD SIDS: Organisation for Economic Co-operation and Development
Screening Information Data Set
PBT: Persistent, Bioaccumulative and Toxic substancePOPs: Persistent Organic Pollutants
STOT: Specific Target Organ Toxicity
SVHC: Substances of Very High Concern
vPvB: Very Persistent and Very Bioaccumulative[Disclaimer]
The information on this material safety data sheet is furnished, expressed or implied, without any
warranty, except that it is assumed to be accurate to the best knowledge of Asahi Kasei Medical.
It relates only to the specific product designated herein, and does not relate to use incombination with any other material or in any process. Asahi Kasei Medical Corporation assumes
no legal responsibility for use of or reliance upon this information.

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Safety Data Safety Sheet for Asahi Integrity Test Solutions Kit
Sodium Lauryl Sulfate

Safety Data Sheet
Section 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product Identifier
Product/chemical name:Index number:
EC number:
CAS number:
REACH number:

SDS (Sodium Lauryl Sulfate)
Not applicable205-788-1
151-21-3
No registration number is available for this substance as thesubstance or its uses are exempted from registration; theannual tonnage does not require registration.

1.2. Relevant identified uses of product: Solely for the post-use GPT of PlanovaTM filters
1.3.Contact information of Manufacturer/Supplier:Name of manufacturer:
Asahi Kasei Medical Co., Ltd.
Bioprocess Division
1-1-2 Yurakucho, Chiyoda-ku, Tokyo 100-0006 JAPAN
Tel: +81-3-6699-3782; Fax: +81-3-6699-3784
Email address: info.jp@ak-bio.com
Name of supplier (importer) in the EU:
N.V. Asahi Kasei Bioprocess Europe S.A.
Rue Colonel Bourg, 122, 1140 Brussels, Belgium
Tel: +32-2-526-0500; Fax: +32-2-526-0510
Email address: info.eu@ak-bio.com
Name of supplier (importer) in the US:
Asahi Kasei Bioprocess America, Inc.
1855 Elmdale Avenue, Glenview, IL 60026 USA
Tel: +1-847-556-9700; Fax: +1-847-556-9701
Email address: info.us@ak-bio.com
1.4. Emergency telephone number
In case of emergency, call the local poison control center.
Section 2: Hazard identification
2.1. Classification of the substance or mixture
Classification according to OSHA HCS:
Physical Hazards

Not classifiedHealth Hazards
Acute toxicity (oral): Category 4
Acute toxicity (dermal): Category 3
Skin corrosion/irritation: Category 2
Eye damage/irritation: Category 1
Specific target organ toxicity single exposure: Category 3 (respiratory tract irritation)
Specific target organ toxicity repeated or prolonged exposure: Category 2 (liver)
Environmental Hazards
Hazardous to the aquatic environment (acute): Category 1

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Sodium Lauryl Sulfate

Other Hazards

No information

Classification according to EU CLP:
Acute Tox. 4: H302
Acute Tox. 3: H311
Skin Irrit. 2: H315
Eye Dam. 1: H318
STOT SE 3: H335 (respiratory tract irritation)
STOT RE 2: H373 (liver)
Aquatic Acute 1: H400
2.2. Label elements:
In accordance with OSHA HCS and EU CLP:
Pictogram(s)Signal word:

DangerHazard statements:
Harmful if swallowed (H302)
Toxic in contact with skin (H311)
Causes skin irritation (H315)
Causes serious eye damage (H318)
May cause respiratory irritation (H335)
May cause damage to liver through prolonged or repeated exposure (H373)
Very toxic to aquatic life (H400)
Precautionary statements:
Prevention
Wash hands thoroughly after handling. (P264)
Do not eat, drink or smoke when using this product. (P270)
Wear protective gloves/protective clothing/eye protection/face protection. (P280)
Use only outdoors or in a well-ventilated area. (P271)
Do not breathe dust/mist/vapors/spray. (P260)
Avoid release to the environment. (P273)
Response
IF SWALLOWED: Call a poison center/doctor if you feel unwell. (P301+P312)
Rinse mouth. (P330)
IF ON SKIN: Wash with plenty of water. (P302+P352)
Take off immediately all contaminated clothing and wash it before reuse. (P361+P364)
If skin irritation occurs: Get medical advice/attention. (P332+P313)
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing. (P305+P351+P338)
Immediately call a poison center/doctor. (P310)
IF INHALED: Remove person to fresh air and keep comfortable for breathing. (P304+P340)

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Sodium Lauryl Sulfate

Collect spillage. (P391)
Storage
Store locked up. (P405)
Disposal
Dispose of contents/container in accordance with local/regional/national/international
regulations. (P501)
2.3. Other hazards:
In accordance with OSHA HCS: No information
In accordance with EU CLP: The substance does not meet the criteria for PBT or vPvB
according to Regulation (EC) No 1907/2006, Annex XIII.
Section 3: Composition/information on ingredients3.1. Substances
Product/chemical name:
Synonym:Index number:
EC number:
CAS number:
Purity:SDS (Sodium Lauryl Sulfate)
Sodium dodecyl sulfate
Not applicable205-788-1
151-21-3
99.0%

Section 4: First-aid measures
4.1. Description of first aid measures
IF INHALED: Remove victim to fresh air and keep at rest in a comfortable for breathing. If
not breathing or breathing is weakened, secure a clear airway then give artificial
respiration.
IF ON SKIN: Take off the contaminated clothes immediately. If on skin, rinse with plenty ofwater immediately.
IF IN EYES: Rinse softly with clean water for at least 15 minutes. Get medical
advice/attention as soon as possible.
IF SWALLOWED: Immediately get medical advice/attention. Rinse mouth. If conscious, getaffected person to drink one or two glass of water then insert fingers into the throat to
induce vomiting. If unconscious, do not induce vomiting.
4.2. Most important symptoms and effects, both acute and delayed
Acute effects:
Harmful if swallowed
Toxic in contact with skin
Causes skin irritation
Causes serious eye damage
May cause respiratory irritation
Delayed effects:
May cause damage to liver through prolonged or repeated exposure
4.3. Indication of any immediate medical attention and special treatment neededShow this Safety Data Sheet to medical personnel. Give symptomatic treatment andsupportive therapy.

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Section 5: Fire-fighting measures
5.1. Extinguishing media
Suitable extinguishing media: Water spray, dry chemical powder, foam, carbon dioxide, or sandUnsuitable extinguishing media: Direct discharge of water jet
5.2. Specific hazards arising from the substance or mixture
If involved in a fire, this product may emit hazardous decomposition and combustion fumes(e.g., sulfur oxides and carbon monoxide).
5.3. Advice for firefighters
Firefighters should use full protective gear for surrounding fire.
Section 6: Accidental release measures
6.1. Personal precautions, protective equipment, and emergency procedures
For non-emergency personnel:
Evacuate, except for responsible personnel
In case of emergency, contact local authorities and responsible personnel
For emergency responders:
Wear appropriate personal protective equipment described in Section 8 (exposure
control) to prevent inhalation and contact with eyes and skin.
6.2. Environmental precautions
Prevent leakage of product into water courses or drainage systems by diking with sand orother absorbent material.
Contact authorities, water company and waste-water treatment plant as appropriate if
significant contamination occurs.
6.3. Methods and materials for containment and cleaning up
Avoid the generation of dust.
Absorb the spill promptly with towels, and clean area with water.
Collect larger spills using techniques such as inert sorbent materials or pumping.
Wash contaminated surfaces with plenty of water.
Follow prescribed procedures for responding to large spills and reporting to appropriate
authorities.
6.4. Reference to other sections
Refer to Section 8 (exposure control) and Section 13 (disposal) as appropriate.
Section 7: Handling and storage
7.1. Precautions for safe handlingContainment and measures for safe handling:
In the storage area, install adequate light and ventilation systems to handle hazardous
materials.
Take precautionary measures against static discharge.
Avoid contact with skin, eyes and clothing. Do not breathe dust. Wash thoroughly after
handling. Keep container tightly closed when not in use.
Incompatible substances or mixtures:
Strong oxidizing agents.

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Advice on general occupational hygiene:
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.
7.2. Conditions for safe storage, including any incompatibilities
Avoid storing under high temperature and high humidity.
Avoid exposure to direct sunlight.
Store at room temperature.
Packing materials: glass, polypropylene, etc.
7.3. Specific end use(s)Integrity test (gold particle test) of Planova filters
Section 8: Exposure controls/personal protection
8.1. Control parameters
Occupational Exposure Limits: Not established in the US or EU.
8.2. Exposure controls
Recommended to handle in fume hood, but careful handling may be sufficient for small
quantities of product.
Use only in facilities equipped with a safety shower, and hand and eye washing facilities near
the handling and storage areas. The locations of these safety facilities must be clearly marked.
8.3. Individual protection measures, such as personal protective equipment:
Respiratory protection: Wear respiratory protective equipment if exposure to dust is likely.
PPE should be to European (EN) or US Standards. Consult manufacturers concerning
breakthrough times.
Skin protection: chemical resistant gloves (e.g., butyl or nitrile rubber) and suitable protective
clothing (e.g., apron, sleeves and boots).
Eye protection: Wear safety goggles.
8.4. Environmental exposure controls:
Take care to not release product into drains, sewers, and streams or other waterways.
Section 9: Physical and chemical properties
9.1. Information on basic physical and chemical properties
Appearance:
White to pale yellow crystalline powder
Odor:
Odorless
Odor threshold:No informationpH:
5 – 8 (10 g/L, 25 °C)
Melting point:
204 °C
Initial boiling point
and boiling point range:
No information
Flash point:
No information
Evaporation rate:
No information
Flammability (solid, gas)
No information
Upper/lower flammability
or explosive limits
No information
Vapor pressure:
No information
Vapor density
No information
Relative density
No information
Solubility(ies)
Soluble in water
Moderately soluble in ethanol
Very slightly soluble in diethyl ether

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Partition coefficient:
n-octanol/water
Auto-ignition temperature
Decomposition temperature
Viscosity
Explosive properties
Oxidizing properties

1.6
No information
No information
No information
No information
No information

9.2. Other information
No information
Section 10: Stability and reactivity
10.1. Reactivity:
This product is considered to be a non-reactive material under normal and anticipatedstorage and handling conditions.
10.2. Chemical stability
Stable under recommended storage and usage conditions.
10.3. Possibility of hazardous reactions
May react with oxidizing agents
10.4. Conditions to avoid
Avoid sunlight, heat, contact with incompatible materials.
10.5. Incompatible materials
Strong oxidizing agents
10.6. Hazardous decomposition products
If involved in a fire, this product will emit hazardous decomposition and combustion fumes(e.g., sulfur oxides).
Section 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity (oral):Acute toxicity (dermal):
Skin corrosion/irritation:

Serious eye damage/irritation:
Skin sensitization:

Germ cell mutagenicity:

Carcinogenicity:
Reproductive toxicity:

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Rat LD50 = 1,200 mg/kg
Rabbit LD50 = ca. 600 mg/kg
According to results of tests in rabbits, “Severely irritating (PII:7.73)”, and “Moderately to strongly irritating”.
Moderately irritating in humans at a concentration of 20%.
Severely irritating to the eyes of rabbits and caused irreversible
corneal effects.
In the OECD SIDS report, it is concluded that alkyl sulfates will
give no concern for skin sensitizing properties based on theavailable data in experimental animals as well as from data inhumans.
(in vitro) Negative in Ames test.
(in vitro) Negative in mouse lymphoma cell forward mutation
assay.
(in vivo) Negative in chromosome aberration assay in rats.
(in vivo) Negative in dominant lethal assay in mice.
No information
No information

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STOT-single exposure:
STOT-repeated exposure:

Aspiration hazard:

Respiratory irritation was observed in mouse, rabbit and guinea
pig those exposed via aerosol.
In a 28-day gavage study with rats, an increase in alanine
aminotransferase (ALT) activity accompanied by an increase of
relative weights of liver was observed. In the OECD SIDS
report, it is concluded that the liver is the only target organ forsystemic toxicity of alkyl sulfates based on results of oral
application tests with chain lengths between C12 and C18.
No information

11.2 Information on the likely routes of exposure
Refer to Section 11.1 (Information on toxicological effects)
11.3 Symptoms related to the physical, chemical and toxicological characteristics
Refer to Section 11.1 (Information on toxicological effects)
11.4 Delayed and immediate effects and also chronic effects from short and long term exposure
Acute effects:
Harmful if swallowed
Toxic in contact with skin
Causes skin irritation
Causes serious eye damage
May cause respiratory irritation
Delayed effects:
May cause damage to liver through prolonged or repeated exposure
11.5 Numerical measures of toxicity
Not applicable
11.6 Interactive effects
No information
11.7 Whether the chemical is listed in the NTP Report on Carcinogens or has been foundto be a potential carcinogen in the IARC Monographs, or by OSHA
IARC: Not listed
NTP Report: Not listed
OSHA: Not listed
Section 12: Ecological information
12.1. Toxicity:

Aquatic acute toxicity:

Aquatic chronic toxicity:

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Crustacea (Homarus americanus) 96 h LC50 = 0.72 mg/L
Algae (Desmodesmus subcapitata) 72 h ErC50 > 120 mg/L
Algae (Pseudokirchneriella subcapitata) 96 h ErC50 = 117 mg/L
Fish (Pimephales promelas) 42 d NOEC > 1.36 mg/L
Crustacea (Ceriodaphnia dibia) 7 d NOEC = 0.88 mg/L
Algae (Desmodesmus subcapitata) 72 h NOEC = 30 mg/L

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12.2. Persistence and degradability: Rapidly degradable
12.3. Bioaccumulative potential: Fish (Cyprinus carpio) BCF = 3.9 – 5.3
12.4. Mobility in soil:
No information
12.5. PBT and vPvB in accordance with EU CLP: The substance does not meet the criteria for
PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
12.6. Other adverse effects:
No information
Section 13: Disposal considerations
13.1. Waste treatment methods
Do not dispose of via the drains or to landfill.
Recycling is the recommended route of disposal.
Disposal must be in accordance with current national and local regulations.
Chemical residues generally count as special waste, and their disposal may be regulated in
EC member countries through applicable laws and regulations.
We recommend that you contact either the authorities or an approved waste disposal
company for advice on disposal of special waste.
General EU requirements are given in the Waste Framework Directive (75/442/EEC) and theHazardous Waste Directive (91/689/EEC).
Packaging and other wastes may contain residues of the product and should be treatedaccordingly.
Section 14: Transport information
14.1. UN number:
14.2. UN proper shipping name:3077
Environmentally hazardous substance, solid
N.O.S. (Sodium lauryl sufate)14.3. Transport hazard class(es):914.4. Packing group:III
14.5. Environmental hazards:
Applicable
14.6. Special precautions for user:
Confirm that containers have no leaks before
moving. Protect containers against fall, drop
and physical damage. Avoid exposure to direct
sunlight.
14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC code
Not applicable

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Section 15: Regulatory information
15.1. Safety, health and environmental regulations specific for the product in question
The substance is not regulated by specific provisions related to protection of human health or theenvironment at EU level, e.g., not considered as SVHCs or POPs.
EU
REACH Regulation (1907/2006).
Regulation (EC) No 1272/2008 on Classification, Labelling and Packaging of Substances and
Mixtures.
Chemical Agents Directive (98/24/EC).
Personal Protective Equipment (EC Directive) Regulations SI 1992/3139.
BELGIUM
Appendix II of the "Règlement Général pour la Protection du Travail (RGPT)" or "Algemeen
Reglement voor de Arbeidsbescherming (ARAB).
Occupational exposure limits: Valeurs Limites d'Exposition Professionnelle (VLEP); or
Grenswaarden voor Beroepsmatige Blootstelling (GWBB); Annex 1 of the arrêté royal du
11 mars 2002 relatif à la protection de la santé et de la sécurité des travailleurs contre lesrisques liés à des agents chimiques sur le lieu de travail; Ministry of Employment andWork.
FRANCE
Decree of 21 February 1990, définissant les critères de classification et les conditions
d’etiquetage at d’emballage des preparations dangereuses, as amended.
The Control of Chemical Products Act, Law 77-771 of 12 July 1977, sur Ie Controle desProduit Chimiques, as amended.
Valeurs limites d'exposition professionelle aux agents chimiques en Institut National deRecherche et de Sécurité, Document ED 984.
GERMANYThe product is self-classified as WGK 1 on the basis of ingredient information.
Chemicals Act: Gesetz zum Schutz vor gefährlichen Stoffen (Chemikaliengesetz - Chem G).
Dangerous Substances Ordinance: Verordnung zum Schutz vor gefährlichen Stoffen(Gefahrstoffverordnung - GefStoffV).
WGK Regulation: Verwaltungsvorschrift wassergefährdende Stoffe (VwVwS).
Occupational exposure limits: List of MAK and BAT Values 2006, Commission for theInvestigation of Health Hazards of Chemical Compounds in the Work Area, Report No.
42, Wiley-VCH.
UK
Chemical (Hazard Information and Packaging for Supply) Regulations 2009 (SI 2009 No 716)
(CHIP4).
Control of Substances Hazardous to Health Regulations 2002 (COSHH).
Health and Safety at Work Act 1974 c 37.
Workplace Exposure Limits EH40/2005 with 2007 supplement, Health and Safety Executive.
UNITED STATESOSHA: Hazardous chemical
TSCA inventory: Listed on the TSCA Inventory.
TSCA SNUR: Not listed
SARA Title III: Not listed
CERCLA Reportable Quantity: Not listed
Clean Air Act: Not regulated
Clean Water Act: Not regulated
CALIFORNIA PROPOSITION 65: Not listed

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Section 16: Other information
Update history:
Date of first issue:
March 17, 2005
Date of most recent revision: September 3, 2021; Supersedes Version 3.0 issued August 26,
2015
References:
Data of Asahi Kasei Medical Co., Ltd.
OECD SIDS Initial Assessment Report, Category of Alkyl sulfates, Alkane sulfonates and αOlefin sulfonates (2007)
NITE GHS classification results (2015)
Full text of Hazard statements referred to in Sections 2 and 3:
H302: Harmful if swallowed
H311: Toxic in contact with skin
H315: Causes skin irritation
H318: Causes serious eye irritation
H335: May cause respiratory irritation
H373: May cause damage to liver through prolonged or repeated exposure
H400: Very toxic to aquatic life
Abbreviations
BCF: Bioconcentration Factor
CAS No.: Chemical Abstracts Service Registry Number
EC: European Community
ErC50: Median Effect Concentration
LD50: Lethal Dose50
NOEC: No Observed Effect Concentration
OECD SIDS: Organisation for Economic Co-operation and Development
Screening Information Data Set
PBT: Persistent, Bioaccumulative and Toxic substancePOPs: Persistent Organic Pollutants
STOT: Specific Target Organ Toxicity
SVHC: Substances of Very High Concern
vPvB: Very Persistent and Very Bioaccumulative[Disclaimer]
The information on this material safety data sheet is furnished, expressed or implied, without any
warranty, except that it is assumed to be accurate to the best knowledge of Asahi Kasei Medical.
It relates only to the specific product designated herein, and does not relate to use incombination with any other material or in any process. Asahi Kasei Medical Corporation assumes
no legal responsibility for use of or reliance upon this information.

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