Powerful advancesin whole-field
electrophysiology
measurements

Introducing

Advanced electrophysiology
focused on your research needs.

Phoenix Research Labs electrophysiology tools are not adaptations ofclinical instruments. Designed specifically for scientific eye research using
laboratory animals, Phoenix delivers technology that empowers research
and fuels scientific discovery.

ERG2 Advancements:
CLEAN - A new algorithm for artifact free removal of mains pickup	Extended dynamic range - ERG now with 27 bits of dynamic range
encompassing STR to ERP	
Enhanced processing - A new level of proficiency in extraction andpresentation of OP

One technology, two platforms
Ganzfeld ERG for rodents• Designed for a crowded lab. The smallest
system for the smallest animals• Powerful, validated, versatile• Built-in electrodes - no more small contact
placement in a darkened lab
800

Amplitude (uV)600
4002000501000-200-400-600
-800
-1000

Time (msec)

Image guided focal ERG for rodents•A ttaches to the Micron IV+ camera• Infrared light guidance keeps animal
totally dark adapted•B uilt-in electrodes - no more small contact
placement in a darkened lab
200150

Amplitude (uV)

1005000

100200300-50-100-150-200-250

Time (msec)

400500150200

The next step in technology
for eye research
The unique Maxwellian view
design enables placing the corneal
electrode on the front lens.
With an infrared camera for
guidance, the electrode canbe gently contacted to thecornea even in the dark, keeping
absolutely dark adaptation andstable contact to the eye.

1rod

UV LEDGreen LED

M coneS cone0400500

Wavelength (nm)

Advanced signal
processing capability
to extract and display
OP signals

600

Measure responses
The Phoenix Ganzfeld delivers bothgreen and UV to enable studies of boththe S and M cones

CLEAN
Recorded signal

The first artifact freealgorithm automatic
ERG
500
for extraction of mains pickup

ERG

500

000.2

0.4

0.6

0.8

1-500

0
00.2

0.4

0.6

0.8

1-500

After CLEAN
500

After CLEAN

CLEAN* “learns” the interfering
signal prior to ERG recording and500subtracts it from the entire trace

000.2

0.4

0.6

0.8

1-500

000.2

0.40.60.81

Peak-to-valley noise reduced from 70 μV to 3 μV, a reduction of over 20 dB-500

70 µV in p-v

Before CLEAN

After CLEAN*Patent pending - Available summer 2015

Ganzfeld
A system for animal eye research with profound flexibility
This waterfall display
encompasses anenormous dynamic
range of 10^8

3
Levels needed
for Early Receptor
Potential

2

1

ISCEV
clinicalstandard-1-2

Log (Cd-sec/m^2)

0

Dynamic rangeof thePhoenix Ganzfeld-3-4
Levels needed
for ScotopicThreshold
Measurements-5

Scotopic Threshold
Response (STR) to
Early Receptor
Potential (ERP)

Peak of B wave

Log	  cd	  sec/m^2	  A waveA wide variety of signal protocols is available through an intuitive interface
504 nm

365 nm

Double pulse, arbitrary wavelength selection

Flicker, arbitrary selection of frequency and backgroundImage-Guided Focal ERG
Regional assessment using deep-red light for targeted study
(A)

(B)

Image guiding using
650 nm light keeps
dark adaptation
(C)

(D)

Spot size: (A) 0.25 mm, (B) 0.5mm, (C) 0.75 mm, and (D) 1.0mm

Bright Field

Advanced signal processing capability
to extract and display OP signals

Waterfalls with 3dB
Increments using
1.5 mm spot diameteron mouse

Waterfalls with 3dB increments using 1.5 mm spot diameter on mouseSpecifications:
Stimuli
Illumination size in diameter

Range of stimulation inlog cd sec/m^2
Modes

Focal ERG

Ganzfeld ERG

White light LED

365nm & 504nm

Mouse: 0.25mm, 0.5mm, 0.75mm, 1.0mm, 1.5mm
Doubled for rat
Micrometer driven targeting

Full field-1.7 to 3.1
Set levels over a range of 10^6-4.7 to 3.1
Set levels over a range of 10^8Single flash
Double/Flicker flash
Continuous background with flash
Light adaptation
Chart mode

Single flash
Double/Flicker flash
Alternate two-color flash
Continuous background with flash
Light adaptation
Chart mode

Pulse length
Objective lenses
Camera0.2 millisecond to minutes
Separate objective lenses for mouse and rat

Single objective lenses for mouse and rat

Integrated with Phoenix Micron IV+

NIR Camera to align pupil(sold separated)

HeaterSet 37 degrees Celsius for Mouse and Rat

Set 37 degrees Celsius for Mouse and Rat

Dark Lab Technology

Illuminate retina for alignment at 680nm
Laboratory at 750nm
Red screen and red illuminated keyboard

Cornea alignment at 850nm
Laboratory at 750nm
Red screen and red illuminated keyboard

Software & Controls forAcquisition and Analysis

Acquisition:
CLEAN* mode to remove 60/120 pickup noise
Controllable Bandwidth
Controllable digitization sampling rate
Controllable scan and display time
Controllable all parameters of LEDs (Delay, pulse length etc..)
Analysis:Automatic measurement of A and B wave peaks
Automatic display of waterfalls
Automatic measurement of OP peaks and implicit time
Averaging with user selection

Animal stage

5 degrees of freedom

Electrodes

Corneal contact (gold-plate objective lens)Tail (ground) and head (reference)*Available Summer 2015

6630 Owens Drive, Pleasanton, California 94588
925.485.1100 T 925.485.1155 F www.phoenixreslabs.com