The 28th Chromatography Symposium (Tokushima, On-line meeting)Thursday, June 10
8:55-9:00 Opening Remarks (Toshio Takayanagi)
9:00-9:40(Makoto Takahashi)
S-01
Strategy of Method Establishment for Bioanalysis in Drug Development
Noriyuki Koyama; Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
9:50-10:35 (Kenji Sueyoshi)
O-01
Molecular weight control and GPC evaluation of ionic polymers(P-01) Kai Nomura (1)*, Tetsuya Tanigawa (1,2), Ken Hosoya (1); (1) Graduate School of Lifeand Environmental Sciences, Kyoto Prefectural University, (2) ChemcoO-02
Kinetic analysis of oxidation of tyrosine with tyrosinase by capillary electrophoresis /(P-05)
dynamic frontal analysis
Masanori Mine (1)*, Hitoshi Mizuguchi (2), Toshio Takayanagi (2); (1) Graduate Schoolof Advanced Technology and Science, Tokushima University, (2) Graduate School ofTechnology, Industrial and Social Sciences, Tokushima University
O-03
Development of a Two-Dimensional Chiral HPLC System for the Simultaneous(P-23)
Determination of Lactate, Hydroxybutyrates and Malate
Hsin-Miao Tsai (1)*, Chin-Ling Hsieh (1), Chiharu Ishii (1), Takeyuki Akita (1), MasashiMita (2), Jen-Ai Lee (3), Kenji Hamase (1); (1) Graduate School of PharmaceuticalSciences, Kyushu University, (2) KAGAMI, Inc., (3) School of Pharmacy, Taipei MedicalUniversity
10:50-11:50 (Kenichiro Todoroki)
I-01
Drug analysis in the police
Kenji Tsujikawa, National Research Institute of Police Science
I-02
Application of Chromatographic Technology to Exposure Dynamic Studies ofEnvironmental Contaminants
Tomohiko Isobe*, Miyuki Iwai-Shimada, Yayoi Kobayashi, Mai Takagi, Shoji F.
Nakayama; National Institute for Environmental Studies
12:10-13:10 Luncheon Seminar
L-01
The Usage technique of ultra pure-water for analysis
Yoshifumi Kuroki*; ELGA LabWater
13:30-14:30

Poster Session (Odd number)

14:45-15:45 (Hirobumi Sunayama)
O-04
The Utilization of Triacontyl-Bonded Silica Coated with Imidazolium Ions forCapillary Ion Chromatographic Determination of Inorganic Anions
Anang SEDYOHUTOMO*, Hiroshi SUZUKI, Chuzo FUJIMOTO; Hamamatsu University
School of Medicine
O-05
Evaluation of Retention Characteristics on Capillary Columns with ZnO Nanowire
Eisuke Kanao (1, 2)*, Katsuya Nakano (3), Takuya Kubo (3), Koji Otsuka (3), TakuroHosomi (4), Takeshi Yanagida (4), Jun Adachi (1, 2), Yasushi Ishihama (1, 2) ; (1) Graduate
School of Pharmaceutical Sciences, Kyoto University; (2) National Institutes of Biomedical
Innovation, Health and Nutrition; (3) Graduate School of Engineering, Kyoto University,(4) Graduate School of Engineering, Tokyo University.
O-06
Development of monolithic columns modified with Metal-Organic-Frameworks
Takuya Kubo (1)*, Ryoichiro Matsuura (1), Nobuhiko Hosono (2), Takashi Uemura (2),Koji Otsuka (1); (1) Graduate School of Engineering, Kyoto University; (2) Graduate SchoolO-07of Engineering, The University of TokyoStudy on retention behavior in ultralow-temperature HPLC with stationary phases ofvarious alkyl chains and development of stationary phase of branched alkyl chains
Shinya Kitagawa*, Takayuki Kanayama, Hajime Ohtani; Graduate School of Engineering,
Nagoya Institute of Technology

16:00-17:00 (Masaki Takeuchi)
I-03
Development of a Hyphenated Analysis System of Ultra-Thin Layer Chromatography
with Surface-Assisted LDI-MS
Tomonari Umemura (1)*, Takao Yasui (2); (1) School of Life Sciences, Tokyo University ofPharmacy and Life Sciences; (2) Graduate School of Engineering, Nagoya University
I-04
Analyses of salivary ions using capillary electrophoresis and relationship with bioactivesubstances
Masanobu Mori*, Graduate School of Science and Technology, Kochi University
Friday, June 11
9:00-9:40(Shinya Kitagawa)
S-02
Metabolome analysis of elements using hyphenated technique
Yayoi Kobayashi*, National Institute for Environmental Studies
9:50-10:50 (Tomonari Umemura)
O-08
Selective Determination of Chiral Amino Acids in Mammalian Plasma Using a TwoDimensional LC-MS/MS System
Chiharu Ishii (1)*, Yukiko Shimizu (2), Takeyuki Akita (1), Masashi Mita (3), Tomomi Ide(4), Tadashi Okamura (2), Kenji Hamase (1); (1) Graduate School of PharmaceuticalSciences, Kyushu University; (2) National Center for Global Health and Medicine(NCGM); (3) KAGAMI Inc.; (4) Graduate School of Medical Sciences, Kyushu
UniversityO-09
Development of a Three-Dimensional Chiral HPLC System for the Extraterrestrial
Amino Acids and Application to Carbonaceous Meteorites
Aogu Furusho (1)*, Chiharu Ishii (1), Takeyuki Akita (1), Masashi Mita (2), Hiroshi
Naraoka (3), Kenji Hamase (1); (1) Graduate School of Pharmaceutical Sciences, Kyushu
University; (2) KAGAMI, Inc.; (3) Department of Earth and Planetary Sciences, Kyushu
University
O-10
Optimization of Analytical Procedure for Rapid Quantification of Serum Level ofFavipiravir for Treatment of COVID-19
Yukiko Moriiwa (1),* Go Morikawa (2), Katsuko Okazawa (2), Akio Yanagida (1); (1)School of Pharmacy, Tokyo University of Pharmacy and Life Sciences; (2) Department ofPharmacy, Hokushin General Hospital
O-11
Development of DNA libraries with/without preorganized structures based on
capillary sieving electrophoresis for selecting aptamers targeting small molecules
Kenji Sueyoshi (1, 2)*, Masahide Wada (1), Tatsuro Endo (1), Hideaki Hisamoto (1); (1)Graduate School of Engineering, Osaka Prefecture University; (2) PRESTO, JST
11:00-12:00 Poster Session (Even number)
12:10-13:10 Luncheon Seminar
L-02
Food analysis by universal detector
Katsutoshi Shimizu, Momoko Miyano, Yusuke Hosen; Hitachi High-Tech ScienceCorporation
13:20-14:20(Takuya Kubo)

I-05
I-06

Data-driven science using metabolomics
Masahiro Sugimoto (1)(2)*; (1) Institute for Medical Science, Tokyo Medical University;(2) Institute for Advanced Biosciences, Kio University
DNA aptamer selection by means of CE separation and machine learning
Shingo Saito (1)*; (1) Graduate School of Science and Technology, Saitama University

14:30

Commendation

14:45

Closing Remarks

Posters
P-01(O-01)
P-02
P-03
P-04

P-05
(O-02)

P-06

P-07
P-08

P-09
P-10

P-11

P-12

P-13

Molecular weight control and GPC evaluation of ionic polymers
Kai Nomura (1)*, Tetsuya Tanigawa (1,2), Ken Hosoya (1); (1) Graduate School of Lifeand Environmental Sciences, Kyoto Prefectural University, (2) Chemco
Investigation of the workflow for method transition to SFC from HPLC
Akitaka Terada*, Yasuyo Sato; JASCO Corporation.
Determination of pyroglutamyl dipeptides in FBRA by LC/ESI-MS/MS
Tatsuya Higashi (1)*, Riko Imamura (1), Yukiko Horie (1,2) and Shigeo Ikegawa (2); (1)Faculty of Pharmaceutical Sciences, Tokyo University of Science, (2) Koken Co., Ltd.
Development of a method for analysis of side-chain dihydroxylated vitamin D3
metabolites in human urine by LC/ESI-MS/MS
Kazunari Takada (1)*, Moeka Togashi (2), Shoichi Kusunose (2), Tatsuya Higashi (2); (1)Graduate School of Pharmaceutical Sciences, Tokyo University of Science, (2) Faculty of
Pharmaceutical Sciences, Tokyo University of Science
Kinetic analysis of oxidation of tyrosine with tyrosinase by capillary electrophoresis /dynamic frontal analysis
Masanori Mine (1)*, Hitoshi Mizuguchi (2), Toshio Takayanagi (2); (1) Graduate School of
Advanced Technology and Science, Tokushima University; (2) Graduate School ofTechnology, Industrial and Social Sciences, Tokushima University
Development of fluorescence derivatization of o-phosphoethanolamine followed byHPLC analysis
Tomomi Sakamoto (1)*, Miharu Nakamura (1), Ryoko Tomita (1), Rintaro Sogawa (2),Chisato Shimanoe (2), Nao Nishijyo (1), Tadashi Hayama (1), Toshihiro Fujioka (1); (1)Faculty of Pharmaceutical Sciences, Fukuoka University, (2) Department of Pharmacy,
Saga University Hospital
Gradient Elution in Non-aqueous Capillary Gel Electrophoresis
Kota Araki*, Isoshi Nukatsuka, Fumihiko Kitagawa; Graduate School of Science andTechnology, Hirosaki University
Amino acid metabolomics approach to diagnosing the major depressive disorder
Sayaka Yagi (1)*, Ryoko Tomita (1), Rintaro Sogawa (2), Chisato Shimanoe (2), Nao
Nishijyo (1), Tadashi Hayama (1), Toshihiro Fujioka (1); (1) Faculty of PharmaceuticalSciences, Fukuoka University, (2) Department of Pharmacy, Saga University Hospital
Evaluation of the retention properties of a triptycene-polymer based stationary phase
Ikari Seiji*, Takuya Kubo, Koji Otsuka; Graduate School of Engineering, Kyoto University.
Development of a selective separation method for exosomes based on the surface
structures
Shuntaro Wada*, Takuya Kubo, Kazunari Akiyoshi, Koji Otsuka; Graduate School ofEngineering, Kyoto University.
Development of Perchlorate Determination Method by Ion Chromatography in RiverWaterMadoka Nishimura (1), Yukari Nakaya (2), Hideji Tanaka (2,3), Masaki Takeuchi (2,3); (1)Graduate School of Pharmaceutical Sciences, Tokushima University; (2) Faculty of
Pharmaceutical Sciences, Tokushima University; (3) Graduate School of BiomedicalSciences, Tokushima University
Kinetic analysis of enzymatic reaction of pyruvate kinase by capillaryelectrophoresis/dynamic frontal analysis
Hiroya Shimizu (1), Masanori Mine (2), Hitoshi Mizuguchi (3), Toshio Takayanagi (3); (1)Graduate School of Sciences and Technology for Inovation, Tokushima University; (2)Graduate School of Adovanced Technology and Science, Tokushima University; (3)Graduate School of Technology, Industrial and Social Sciences, Tokushima UniversityDevelopment of Portable On-Line Analytical System for NH3 Gas
Haruka Tanaka (1)*, Makoto Namikawa (1), Hideji Tanaka (1,2) , Masaki Takeuchi (1,2);(1) Faculty of Pharmaceutical Sciences, Tokushima University; (2) Graduate School of

P-14

P-15

P-16

P-17

P-18

P-19
P-20

P-21

P-22

P-23
(O-03)

P-24

Biomedical Sciences, Tokushima University
Metabolomic analysis of ocular-related diseases by simultaneous analysis of watersoluble metabolites using LC-MS
Yasuko Aita (1)*, Atsumi Tomita (1), Ryo Wakita (2), Yumi Aizawa (1), MasahiroSugimoto(1, 3), Yoshiko Usui (2), Hiroshi Goto (2); (1) Tokyo Medical University; (2)Tokyo Medical University Hospital; (3) Keio University
Study on adsorption properties of particulate sorbent-molded media bound bycommercial adhesives
Yuta Miki*, Hiroya Murakami, Yoshinori Inoue, Norio Teshima; Department of AppliedChemistry, Aichi Institute of Technology
Rapid Determination of Volatile Organic Compounds in Soil Samples using NeedleType Extraction Device
Shuhei Kamei (1)*, Ikuo Ueta (1) , Yoshihiro Saito (2); (1) Department of Applied Chemistry,University of Yamanashi; (2) Department of Applied Chemistry and Life science, Toyohashi
University of Technology
Determination of Volatile Organic Compounds in Water using Porous PTFE
Membrane and Needle-Type Extraction Device
Taiga Komatsu (1)*, Ikuo Ueta (1), Yoshihiro Saito (2); (1) Department of AppliedChemistry, University of Yamanashi ; (2) Department of Applied Chemistry and Life
Science, Toyohashi University of Technology
Development of Immunochromatographic Method for Simple Drug Quantification
Using Anti-Idiotypic DNA Aptamers as Capture Molecules
Ryota Isobe*, Nao Kobayashi, Tomohiro Yamada, Eiji Sugiyama, Hajime Mizuno,Kenichiro Todoroki; School of Pharmaceutical Sciences, University of Shizuoka
Development of the molecularly imprinted polymers using halogen bonding
Hayato Osaki 1*, Takuya Kubo 1, Daisuke Nakajima 2, Koji Otsuka 1; 1 Kyoto
University, 2 National Institute for Environmental Studies.
HPLC fluorescence method for eugenols derivatized with DIBI in basil products
Makoto Takada (1)*, Masashi, Sakamoto (1), Haruna Yamada (2), Naoya Kisikawa (3),Junpei Mutoh (1), Yukihide Shiraishi (2), Naotaka Kuroda (3), Mitsuhiro Wada (1); (1)Faculty of Pharmaceutical Sciences, Sanyo-onoda City University; (2) Faculty ofEngineering, Sanyo-onoda City University; (3) Graduate School of Biomedical Sciences
Retention Behavior of Poly(4-vinylpyridine) Stationary Phase in Reversed-Phase
Liquid Chromatography
Koki Nakagami (1)*, Ohjiro Sumiya (1), Keiichi Shimizu (1), Ikuo Ueta (2), Yoshihiro
Saito (1); (1) Department of Applied Chemistry and Life Science, Toyohashi University ofTechnology; (2) Department of Applied Chemistry, University of Yamanashi
A durable and generalized method to determine N-nitrosodimethylamine in drug
substances using off-line solid-phase extraction followed by liquid chromatography–
tandem mass spectrometry
Eiichi Yamamoto*, Hitomi Kan-no, Naomi Tomita, Daisuke Ando, Tamaki Miyazaki, Kenichi Izutsu; National Institute of Health Sciences
Development of a Two-Dimensional Chiral HPLC System for the Simultaneous
Determination of Lactate, Hydroxybutyrates and Malate
Hsin-Miao Tsai (1)*, Chin-Ling Hsieh (1), Chiharu Ishii (1), Takeyuki Akita (1), Masashi
Mita (2), Jen-Ai Lee (3), Kenji Hamase (1); (1) Graduate School of PharmaceuticalSciences, Kyushu University, (2) KAGAMI, Inc., (3) School of Pharmacy, Taipei MedicalUniversity
Enantioselective Analysis of Lactate in Japanese Traditional Amber Rice Vinegar andthe Developmental Changes During Fermentation Processes
Chin-Ling Hsieh (1)*, Chiharu Ishii (1), Takeyuki Akita (1), Akira Fujii (2), Masanobu
Nagano (2), Masashi Mita (3), Jen-Ai Lee (4), Kenji Hamase (1); (1) Graduate School of
Pharmaceutical Sciences, Kyushu University, (2) Sakamoto Kurozu, Inc., (3) KAGAMI,Inc., (4) School of Pharmacy, Taipei Medical University)

P-25

P-26
P-27

P-28

P-29

P-30

P-31

Analysis of Serine Enantiomers in Human Plasma Using a Tandem Column 2DHPLC System
Chinatsu Yamasaki (1)*, Chiharu Ishii (1), Takeyuki Akita (1), Masashi Mita (2), TomomiIde (3), Kenji Hamase (1); (1) Graduate School of Pharmaceutical Sciences, Kyushu
University; (2) KAGAMI Inc.; (3) Graduate School of Medical Sciences, Kyushu
University
Simultaneous Determination of 15 Saccharides Without Interference by Salt inSeasonings
Natsuki Iwata*, Shinnosuke Horie, Yoshihiro Hayakawa; Shimadzu Corporation
Development of a fluorescent derivatization-HPLC method for β-aminoisobutyricacid, a skeletal muscle condition biomarkerYosuke Shibata* (1), Daichi Hamada (1), Yuki Shinba (2), Eiji Sugiyama (1), Hajime
Mizuno (1), Shinji Miura (2), Kenichiro Todoroki (1); (1) School of PharmaceuticalSciences, University of Shizuoka; (2) School of Food and Nutritional Sciences, Universityof Shizuoka
Switching Separation Modes in Quercetin-imprinted Polymer Bearing Iron
Porphyrin Residues
Utano Kawashima*, Miki Nakaoka, Nodoka Terao, Ryuya Sato, Haruka Ido, SakuraOnishi, Issei Suenaga, Takashi Murashima, Jun Matsui; Department of Nanobiochemistry,Konan University
Human Serum Albumin-imprinted Polymer Nanogels Prepared Using a Monomer
Possessing Ligand Moiety
Takahiro Morishita (1), Hirobumi Sunayama (1)*, Yukiya Kitayama (1), Toshifumi
Takeuchi (2,3); (1) Graduate School of Engineering, Kobe University; (2) Innovation
Commercialization Division, Kobe University, (3) Center for Advanced Medical
Engineering Research & Development (CAMED), Kobe University
Pyrethroid pesticides analysis in human plasma using polypyrrole nanowires for
microextraction
Yanting Song (1), Makoto Tsunoda (2)*; (1) School of Pharmaceutical Sciences, Hainan
University; (2) Graduate School of Pharmaceutical Sciences, University of Tokyo
Structural determination of clinofibrate photoproducts generated by UV irradiation
based on ESI-LC/MS/MS analysis
Kohei Kawabata*, Masanori Inagaki, Hiroyuki Nishi; Department of PharmaceuticalChemistry, Faculty of Pharmacy, Yasuda Women’s University