Application Guidebook for Foreign Students
Graduate School of Medical Sciences (Doctor of Philosophy Degree Program)
Nagoya City University
for Academic Year 2024（October Enrollment）
Admission policy of Graduate School of Nagoya City University
Nagoya City University (NCU) aims to be a university in which all citizens feel pride and affinity. In graduate
education, based on recognition that research guidance, for graduate students is a challenge in offering research
activities; We aim to cultivate researchers and professionals who can gain advanced expertise and aninterdisciplinary thinking.
With this philosophy and aim, the graduate school is widely looking for individuals who possess advanced
expertise and an eagerness and aptitude for activity both within Japan and abroad, in addition to diverse skills andwork experience.

[Doctor of Philosophy Degree Program in Graduate School of Medical Sciences of NCU]
《Desirable Students》
・Individuals who aspire to be an international medical researcher capable of leading medical research in future・Individuals who intend to be a medical professional capable of establishing and practicing the most advanced
medical care《Content and level of knowledge that applicants should have been acquired》
In addition to sufficient English proficiency to understand and write papers in English, in order to performresearch in medicine/life sciences, applicants are to have knowledge of life sciences and/or of basic medicine
at a level of those who have completed a Master’s degree program, or applicants are to have basic medical
treatment technique, knowledge and experience in the clinical practice necessary to receive training on themost advanced medical care.
1. Prescribed enrollments (Total of April and October enrollment)
Major
No. of Enrollment Major
Structure and Function in
Biodefense System andBiomedical Sciences
32
Comprehensive Medical
Sciences
Biosignaling and Regulation
Community Medicine,in Medical Sciences
28
Environmental Health Sciences
and Medical Education

No. of Enrollment
328Note 1: Prior to submitting application documents, please contact the faculty member in charge of thedepartment where you wish to belong, and consult with him/her regarding your application.
Note 2: In some programs, a medical license may be required for your research theme. Please consult with thefaculty member beforehand with your application.

2. Eligibility of applicants
All applicants must satisfy at least one of the following conditions:(1) A person who has completed a program in medicine, dentistry, pharmacy or veterinary medicine (limited
to 6 years for pharmacy and veterinary medicine) and graduated from university or is expected to graduate
from university by September, 2024.
(2) A person who has completed an18-year program (limited to programs including a course in medicine,
dentistry, pharmacy or veterinary medicine) in school education in a foreign country or is expected tocomplete such a program by September, 2024.
(3) A person who has completed an 18-year program (limited to programs including a course in medicine,
dentistry, pharmacy or veterinary medicine) in school education in a foreign country by completing inJapan the same program of correspondence education provided by the foreign country or is expected tocomplete such a program by September, 2024.
-1-

---------------------------------------------------------------------------------------------------------------------------------Contact details: Administration officer, Administration Office, Graduate School of Medical Sciences, Nagoya
City University E-mail : med-daigakuin sec.nagoya-cu.ac.jp Inquiries must be made by e-mail.
(4) A person who has completed or is expected to complete by September, 2024 an 18-year program (onlylimited programs including a course in medicine, dentistry, pharmacy or veterinary medicine) of theforeign educational institution established in Japan based on the educational system of this foreigncountry. In such cases, the institution should be specified by the Minister of Education, Culture, Sports
Sciences and Technology of Japan.
(5) A person who has completed or is expected to complete by September, 2024 a 5-year or more year’s
program in the university or other tertiary institution in a foreign country assured by the government orauthorized organization in the original country, or specified by the Ministry of Education, Culture, Sports,
Science and Technology of Japan. The program includes the comprehensive education study provided by
the foreign university in tertiary institution in Japan, or the program provided by the foreign educational
institution in Japan based on the educational system of the original country. In such cases, the institution
should be specified by the Ministry of Education, Culture, Sports, Science and Technology of Japan.
(6) A person who has been designated by the Minister of Education, Culture, Sports, Science and Technologyof Japana. A person who has graduated from National Defense Medical College established under the Ministry of
Defense Establishment Law (Law No. 164, 1954) or is expected to graduate from said college bySeptember, 2024.
b. A person who has completed a master’s program or is qualified to be awarded the master’s degree, andbeen enrolled in a doctoral program (not divided into 2 segments: first 2-year for master’s course andsecond 3-year for doctor’s course) for 2 years or more, acquired 30 or more credits, received necessary
research guidance, and is determined by the Graduate School of Medical Sciences to have an academic
ability equivalent to or better than those who have completed a program of medicine, dentistry,
pharmacy or veterinary medicine at university.
c. A person who has graduated from university (excluding a course in medicine, dentistry, pharmacy orveterinary medicine) or completed a 16-year program of school education in a foreign country,
subsequently been engaged in research for 2 years or more at a university, research institute or the like,and is determined by the Graduate School of Medical Sciences from their achievements in suchresearch to have an academic ability equivalent to or better than those who have completed a programof medicine, dentistry, pharmacy or veterinary medicine at university.
(7) A person who has been enrolled in university (only limited a course in medicine, dentistry, pharmacy orveterinary medicine) for 4 years or more, or completed a 16-year program (only limited programs
including a course in medicine, dentistry, pharmacy or veterinary medicine) in school education in aforeign country, and is determined by the Graduate School of Medical Sciences to have acquired theprescribed credits with excellent academic results.
(8) A person who has determined by the Graduate School of Medical Sciences to have academic ability
equivalent to or better than that those defined in (1) and will be 24 years old by September 30, 2024.
Note 1: Prior to submitting application materials to NCU, please contact the faculty member whom you would
like to have as a supervisor, and consult him/her about your application.
Note 2: Some programs may require a medical license depending on your research theme. Consult with faculty
member in advance, whom you would like to have as a supervisor.

3. Screening of Qualification for the examination under Category (6)b, (6)c, (7) or (8) as described above(1) Application period for “Screening of Qualification for the examination”
June 19 (Wed) – June 26 (Wed), 2024 ※must be reached at the end of period.
(2) Application documents
Applicants who fall under Category (6) b , (6) c , (7) or (8) must write in red “application qualification
documents, Graduate School of Medical Sciences, Doctor of Philosophy Degree Program （October
Enrollment）”on the envelope and send the following documents by registered express post, or bring them inperson to the address of NCU in page3.
※If you would like to apply from overseas, please make sure to entrust your application procedure to theproxy residing in Japan. Application directly from overseas will not be accepted. Notifications from NCU will
be sent to your proxy’s address.
-2-

Applicants who fall under Category (6) b,
Send the following documents ; (ⅰ) Request for Screening of Eligibility for Examination (prescribed formof “D-5”),(ⅱ)Resumé (prescribed form of “D-2”), (ⅲ)Certificate of Completion of graduate school, and (ⅳ)
Academic Transcript of graduate school.
Applicants who fall under Category (6) c,
Send the following documents ; (ⅰ) Request for Screening of Eligibility for Examination (prescribed formof “D-5” ),(ⅱ)Resumé (prescribed form of “D-2”), (ⅲ) Diploma, (ⅳ) Academic Transcript ,(ⅴ)Certificate of Engagement in Research, and（ⅵ）Achievement Records (prescribed form of “D-6”).
Applicants who fall under Category (7): A person who has been enrolled in university (limited to c a course in
medicine, dentistry, pharmacy or veterinary medicine) for 4 years.
Send the following documents ; (ⅰ) Request for Screening of Eligibility for Examination (prescribed
form of “D-5”),(ⅱ)Resumé (prescribed form of “D-2”), (ⅲ) Academic Transcript , (ⅳ) Course Curriculum ,and , (ⅴ) Syllabus of the university.
Applicants who fall under Category (8): A person who has been completed a 16-year program(limited to programs including a course in medicine, dentistry, pharmacy or veterinary medicine) in
school education in a foreign country.
Send the following documents ; (ⅰ) Request for Screening of Eligibility for Examination (prescribed
form of “D-5”),(ⅱ)Resumé (prescribed form of “D-2”), (ⅲ) Diploma, and (ⅳ) Academic Transcript.
Applicants who fall under Category (8),Send the following documents ; (ⅰ) Request for Screening of Eligibility for Examination (prescribed
form of “D-5”),(ⅱ)Resumé (prescribed form of “D-2”), and (ⅲ) “Diploma” of schools after junior highschool (senior high school, junior college, other school) if you have graduated from such school.
※Some documents such as “Certificate of Completion”, “Diploma”, “Academic Transcript” and “Certificate ofEngagement in Research” must be written in Japanese or English, or the translated documents in either of theselanguages should be attached.
※D-2, D-5 and D-6 forms can be downloaded from the following website.

URL: https://www.nagoya-cu.ac.jp/english/faculty/admissions/med/index.html
Office hours: 9:00 – 16:00 (excluding Saturday, Sunday and National Holiday and between 12:00 – 13:00)
Send application document by registered express post or hand-delivery to:Student Affairs Division, Administration Office, Nagoya City University
1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan(3) Results of the screening
The results of the screening will be notified by post to applicants as early as possible.
Applicants who passed the screening can apply to the examination.

4. Period of application
July 12 (Fri) – July 19 (Fri), 2024 ※must be reached at the end of period.
Office hours: 9:00 – 16:00 (excluding Saturday, Sunday and National Holiday and between 12:00 – 13:00)
Enclose the application documents, etc. into the A4 sized envelope, stick NCU designated address label whichshould be filled in the details and send them by registered express mail. Instead of post, hand-delivery to theabove address will be also acceptable.
Applications which cannot reach by the designated date will not be acceptable. (the date printed on the
postmark is not accountable.)
If you would like to apply from overseas, please make sure to entrust your application procedure to the proxy-3-

residing in Japan. Application by post directly from overseas will not be accepted. Notifications from NCU
will be sent to your proxy’s address.
Once your application documents are accepted, admission card and Test center information will be posted toapplicants before August 1st (Thu). If you did not receive by those dates, please contact the administrators,
Office of Medical School (refer to page1).

5. Application documents, etc.
Documents, etc.
12Application foradmission/
Photo
Identification
card/
Examination
Admission card
Resumé

3

Academictranscript

4

Diploma(graduation
letter)5

Letter of
permission fortakingexamination
Residencecertificate

6

Description[Use the prescribed form of “D-1”]
・ Stick your photograph on the application form. A photograph should be taken within
3 months, full-faced, upper body, no caps or hats, no background, full-color andsized 4cmx3cm.
・ Please fill in the address which you are (or a proxy is) certain to be contacted.
[Use the prescribed form of “D-2”]
・ Fill in your school education history from elementary education (elementary
school).
・ Provide details of your academic background including Japanese-language school,
and other special training school, and of employment history, if any.
・ Academic transcript should be prepared by university you are currently enrolled inor have graduated from.
If you graduated (or are expected to graduate) from the Medical School of NCU, it
is not necessary to submit.
・ If you submit an application under Category (2), (3) ,(5), (6)c or (7) of “2. Eligibilityof applicants,” and you have completed a 16-year program in school education in aforeign country, submit one of higher education (equivalent to university) completed
in a foreign country.
・ A photocopy will not be acceptable (*Note 2) .
・These documents must be written in Japanese or English, or the translated document
in either of these languages should be attached. In this case, however, prepare thetranslation documents separated from the original transcript.
・ Your diploma should be prepared by the university where you are enrolled or have
graduated.
If you graduated (or are expected to graduate) from the Medical School of NCU, it
is not necessary to submit the diploma.
・ If you submit an application under Category (2), (3) ,(5), (6)c or (7) of “2. Eligibilityof applicants,” and you have completed a 16-year program in school education in aforeign country, submit your diploma of higher education (equivalent to university)
completed in a foreign country.
・ A photocopy will not be acceptable (*Note 2) .
・These documents must be written in Japanese or English, or the translated document
in either of these languages should be attached. In this case, however, prepare thetranslation documents separated from the original transcript.
[Use the prescribed form of “D-4”]
If you plan to work at any place other than NCU after enrollment, submit the letter
issued by your supervisor at your place of work.
・ If you are a foreign national and eligible for residence in Japan, residence certificate
is required to submit.
・ If your visa status is for short-term residence, submit a photocopy of the Japan entry
visa stamped on your passport.
・ If you are residing in a foreign country, submit a photocopy of your passport.
※Residence certificate without the “Social Security and Tax Number System” isaccepted. If the number is printed on the certificate, please make sure to make it-4-

7

Examination fee(30,344 yen)invisible by using a permanent black pen.
【Paying the examination fees in Japan】
・ When paying the examination fees, fill in the transfer request form (prescribed formof NCU) with the required information, and present it with 30,344 yen (30,000yen
for Examination fee + 344yen for Express mail fee for the admission card to be sent)
at bank, etc. for transfer. (Yucho Bank does not accept this transfer. Do not use an
ATM, etc.; use only a teller service.)
・ The relevant bank fees are to be paid by the applicant.
・ Submit the “Examination Fee Payment Certificate (Slip B)” received from the bank,etc. together with the other application documents. (Do not submit the “Receipt ofTransfer Amount (and Transfer Fee) (Slip A),” which should be retained by you.)・ The examination fee is not normally refundable in principle. However, under a few
circumstances, the paid examination fee may be refunded. Confirm this on the NCU
website.
ex.) The examination fee was transferred twice.
ex.) The application documents were not submitted after the examination fees
have been transferred (or the application was not accepted).
【Paying the examination fee from overseas】
Transfer application fees of 30,344 yen (30,000yen for Examination fee＋344yen
for Express mail fee for the admission card to be sent) to the following accounts by
July 19 (Fri), 2024 and submit a copy of the foreign remittance request form.
Type of Transfer: Electronic Transfer
Bank Transfer Fees: Paid by the remitter
Amount of Transfer: 30,344 yen (JPY) ＋all fees associated with the transfer
1) The remitter should pay “Japanese bank fees,” “remitter’s bank fees,”
and all fees associated with the transfer.
2) If you transfer money in foreign currency, your application will not be
accepted.
Purpose of Transfer: Application fees

8

Mailing label

9

NCU Address
label[Application Fields]
Bank Name: The Bank of Mitsubishi UFJ, LTD
Bank Branch: Takiko Branch
Account Number: 1232518
Beneficiary Name: Nagoya City University
Address: 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601 JAPANCurrency: JPY
Swift Code: BOTKJPJT[Use the prescribed form of NCU]
The mailing label will be used to announce the examination result to the applicants.
Filled in the details on the designated address label and stick it onto A4sized envelop
to be sent to the Entrance Examination and Public Relations Division.

Note1:

If you have already submitted the documents required for application at the screening of qualification for
examination, it is not necessary to submit them again when applying for the exam.

Note2:

If any of your “Diploma,” “Academic Transcript” and other certificates issued by a higher educational
institution in a foreign country cannot be reissued, a photocopy is acceptable. If a photocopy is
submitted, the original certificates must be presented at the administration office, Entrance Examination
Division when you come for the admission procedure.

Note 3: If the name written on your “Academic Transcript”, “Diploma” or other certificates is different fromyour current name, provide the document prove that your name has been changed (e.g., family register).
Note 4: D-2 and D-4 forms can be downloaded from the following website.
-5-

URL: https://www.nagoya-cu.ac.jp/english/faculty/admissions/med/index.html
6. Prior consultation with the applicants with disability
Applicants who need special assistance for their disability during the examination or to complete theirgraduate studies should contact to the administrator, Office of Medical School, NCU by e-mail (refer to page1).
7. Date and method of selection for admission
Examination
Examination dateExamination subject
Examination place
time
Medical Science and Biological Science
Lecture Room A, 11th
13:00-15:00(Written test)
floor, Medical School
Research Building
Question will be written in English or
Japanese (to be selected by applicant
when submitted application)
English (Written test)
Lecture Room A, 11th
Question will be written in English or
floor, Medical School
15:30－17:00
August 6 (Tue),
Japanese (to be selected by applicant
Research Building2024
when submitting application)
Dictionaries may be permitted except
electronic one.
Specialized subject (Interview)
Room in the faculty of
The applicant’s specialized subject (See the specialized subject
17:30－“Research Contents Classified bySpecial Fields of Study”)
Note: Examinees should meet at the examination place (Lecture Room A on the 11th floor of Medical School
Research Building) 15 minutes prior to the start time of each examination.

8. Results of examination
September 2 (Mon), 2024 at 14:00
The results of the examination will be announced on the bulletin board on the 1st floor of the Medical School
Research Building of NCU, and also posted to each applicant. (Please contact Administration Office ofGraduate School of Medical Sciences (refer to P.1), if the result won’t be delivered even one week after theannouncement day.)
9. Admission procedure(1) Expected date of procedure
Date of procedure of first examination is scheduled in September, 2024.
Details schedule will be noticed at the announcement of examination results.
(2) Details of procedure
The details of the procedure will be notified to you together with the results of the examination.
(3) Fees payable during the admission procedurea. Admission fee
Nagoya City residents, etc.
232,000 yen
Others332,000 yen
b. Disaster and accident insurance for student education and research
3,300 yen
Note 1: The admission fee should be paid through a financial institution before commencing theadmission procedure. The paid admission fee is not refundable.
Note 2: “Nagoya City residents, etc.” means ‘enrolled students’ or ‘those whose spouse or first-degree
family member can prove that his/her continuous residential period in Nagoya city is at least one
year before the date of admission by his/her resident certificate’.

10. Immigration clearance
If the legitimate immigration clearance fails to be completed by the time limit for admission, the admission
may be revoked. For details of admission, contact the following for confirmation:-6-

Immigration Information Center [ (Nagoya)]
5-18, Shoho-cho, Minato-ku, Nagoya, Aichi 455-8601
Tel: +81-52-559-2151

11. Tuition
Annual amount
535,800 yen (267,900 yen per semester for 1st and 2nd semesters)
Note 1: After admission, tuition is to be paid twice a year (for the 1st semester and the 2nd semester)(automatic withdrawal from your account).
Note 2: Any revisions to the tuition during enrollment shall become effective immediately.
Note 3: Graduate School of Medical Sciences may charge additional cost without any notification inadvance.
12．A waivers of tuition
Students who can hardly afford the tuition fees with financial reasons and who are recognized to beachieving excellent results in their academic work can apply for a waiver of either full, half, or a quarter of
their tuition fees.
13. Scholarship system
Scholarships of the Japan Student Services Organization (JASSO) are available to graduate students.
Students wishing to apply to the programs will be referred following a review of academic achievement,
research ability, etc., to determine eligibility.
14. Cautions(1) Applications lacking necessary documents will not be accepted.
(2) Applications found to have made false statements in their applications may have their admission revokedeven after their enrollment.
(3) Application documents, etc. will not be returned.
(4) If your return address has been changed, notify it immediately to the administrator, Office of Medical
School, NCU by e-mail (refer to page 1).
(5) A double enrollment is prohibited under the rule.
15. Cooperative graduate school system
Cooperative graduate school system is a method of providing graduate education by utilizing facilities,
equipment and human resources of national, public or private off-campus research institutions acknowledged
as a high research standard. The Graduate School of Medical Sciences of NCU has cooperative agreementswith the National Cancer Center, the National Institute of Infectious Diseases, and the National Center for
Global Health and Medicine.

-7-

Notifications from NCU in case of emergency
In case of emergency (e.g., occurrence of disaster) or if changes are required to the contents of thisapplication guidebook, students will be notified those changes through the website of NCU. Particularly as
the examination day draws near, pay close attention to the website of NCU.
Applicants may also be directly contacted. In your application documents, therefore, be sure to provide
contact details where you can always be reached.
NCU Website
https://www.nagoya-cu.ac.jp/

Treatment of your personal information
NCU treats your personal information in accordance with the Act on the Protection of Personal Informationof Nagoya City.
(1) Use of your personal informationa. Your name, address and other personal information given in application documents, etc. are used forour operations of selection for admission (e.g., application registration, selection, application result
announcement, admission procedure).
b. Your personal information used for selection for admission (e.g., academic transcript) may be used as
reference material for investigative research and academic research to improve future selection foradmission and graduate education. (Investigative research results are announced in such a way that
individuals cannot be identified.)c. After you are admitted, your personal information is used for operations related to educational affairs(e.g., enrollment management, schooling guidance), student support (e.g., health control, tuition
waiver, application for scholarship, job placement support), and tuition collection.
(2) Entrustment of operations to external business operators
The operations of (1) above may be entrusted to some external business operators under an agreementwith them for proper treatment of personal information.

Smoke free campus
NCU hold the smoke free policy on campus. All students are required to follow this policy, and asked tofurther cooperate to avoid smoking on roads and around university campuses.

-8-

MajorSpecialized field of study

Research contents

Faculty member in charge
Integrative Anatomy

Prof.Takatoshi Ueki
Anatomy and Neuroscience
Prof. Shinya Ugawa
Biochemistry(TBA)
Cell Biology
Prof. Yoichi Kato
Cell Physiology

Prof. Hikaru Hashitani
Neurophysiology and Brain
Science

Structure andFunction in
Prof. Hideki Hida
Biomedical
Sciences
Gastroenterological Surgery
Prof. Shuji Takiguchi(1) Molecular neurological studies aiming at comprehensive understanding of pathophysiology ofneurodegenerative diseases such like amyotrophic lateral sclerosis (ALS), and studies of molecularmachinery underlying the involvement of dysfunction of neuron-glia interaction in the onset and progressof those diseases.
(2) Molecular neurobiological studies of homeostasis of neuroimmune system, and pathophysiology ofdysfunction of neuroimmune system and its association with the etiology of neurodevelopmental
disorders such as autism.
Conducting seamless research into both sensory organs and the brain(1) Identification of auditory/gustatory recipience; and functional analysis using genetically-modified
animals(2) Morphological / molecular biological / physiological research into the new nerves of adult brain
hippocampus(TBA)
Cilia are antenna-like organelles which are outgrowths of the plasma membrane of eukaryoitc cells. They
are known to be related to a wide rage of diseases. We focus on the following subjects; (1) Elucidating
the mechanism of ciliogenesis (2) Understanding the regulatory mechanism of signal pathways by cilia(3) Dissecting the pathogenesis of ciliopathies (4) Discovering the roles of cilia in various diseases
Investigations into the functional and morphological characteristics of smooth muscle cells and theirneighbouring cells.
(1) Generation and propagation of spontaneous activity in smooth muscle.
(2) Neurohumoral regulation of smooth muscle function.
(3) Intrinsic properties of microvasculature in visceral organs.
Major techniques employed: electrophysiology, intracellular calcium imaging and fluorescentimmunohistochemistry.
Neuroscience & neurophysiological techniques are used to know physiological brain function throughthree projects with pathophysiological analyses. 1) the mechanism of forelimb function recovery after
intracerebral hemorrhage by rehabilitation 2) the mechanism of function recovery by stem cell (ES / iPScell) transplantation in a model of neonatal white matter injury 3) the mechanism in the formation ofemotion by gut-brain interaction that is activated by umami ingestion
Analysis of mechanisms of tumorigenesis, invasiveness, metastasis, and angiogenesis in digestive organ.
Inflammation and cancer. Nutrition, Immunity and Inflammation. Development of techniques inlaparoscopic surgery. Surgical Infection.

Thoracic and Pediatric Surgery Research on the surgical and molecular target therapy for thoracic malignant tumors including lungcancer and thymic epithelial tumors. Especially focused on the clinical and scientific usefulness ofminimally invasive surgery for thoracic malignancies.
Prof. Katsuhiro Okuda
Nephro-urology
Prof. Takahiro Yasui
Cardiovascular Surgery
Prof. Hisao Suda
Breast Surgery
Prof. Tatsuya Toyama
Pediatric urology

Prof. Yutaro Hayashi

Molecular biology for urolithiasis, endoscopic urology, prostate cancer and bone metastasis,thermotherapy for urological cancer, male infertility and reproductive urology, space urology,
technological development for urological surgery, bimolecular science for urology, genetic therapy,
development for voiding function, epigenetic mechanism for urological disease, congenital urologicalbasic research, Robotics, VR technology.
Development of surgical simulation and training method using 3D printing technology and VR (Virtual
Reality) technology. Research on social implementation (entrepreneurship) through medical device
development. Application ofhydrogen gas, which has anti-arteriosclerosis and anti-inflammatory effects,
to cardiovasucular diseases.
1. Research on molecular mechanisms of hormone dependent growth in breast cancer, 2. Research on
predictive factors of endocrine therapy in breast cancer, 3. Research on "triple negative" breast cancer,
4. Research on prognostic factors in breast cancer.
Basic and clinical researches about etiology, diagnosis, and treatment of pediatric or congenital disease.
(1) Kidney and urinary tract: differentiation of the kidney; regenerative medicine of the kidney using
ES/iPS cells; etiology of the CAKUT (congenital anomalies of the kidney and urinary tract); investigationof the histology and gene expressions in hydronephrosis or vesicoureteral reflux(2) Gonad and genitalia: molecular biological mechanism of sex differentiation, testicular development,
testicular descent, spermatogenesis, and differentiation of external genitalia; differentiation of
spermatogonial stem cells; endocrinology(3) Others: pediatric oncology, rare disease such as cloacal exstrophy-9-MajorSpecialized field of study

Research contents

Faculty member in charge
Ophthalmology and Visual
Science

Basic researches to elucidate pathogenesis of vitreoretinal diseases, clinical reaserches for diagnosis andtherapy by multi-modal imaging, and researches on artificial intelligence (AI)(1) Pathogenesis of age-related macular degeneration (lipid metabolism and roles of macrophages andmast cells)(2) Ocular drug delivery system（DDS）（intraocular sustaind release of drug）(3) Regenerative medicine by use of a cell sheet(4) Multi-modal imaging to elucidate pathogenesis of retinal vein occlusion
Prof. Tsutomu Yasukawa(5) Focal laser phogocoagulation by navigation system to treat diabetic macular edema(6) AI-assisted imaging devices and data science in the field of Ophthalmology
1. Investigation of the molecular mechanism of hereditary hearing loss and development of new
Otolaryngology, Head andtreatment for sensorineural hearing loss 2. Investigation of the molecular mechanism of facial nerve
Neck Surgery
palsy and development of new surgical treatment 3. Development of new diagnostic device and new
Structure andtreatment strategy for peripheral vestibular dysfunction 4. Investigation of the immune mechanisms of
Function inhead and neck cancer and development of new treatments using oncolytic virus 5. Investigation of theProf. Shinichi Iwasaki
Biomedical
mechanism of spasmodic dysphonia and development of new methods of thyroplasty
Sciences
Mechanism analysis and development of phototherapy for refractory skin diseases
Geriatric and Environmental
Development of treatment using dendritic cells for allergic, autoinflammatory and malignant diseases
Dermatology
Environmental factors and skin aging
Prof. Akimichi Morita
Peripheral immune tolerance and cutaneous immune regulation
1. Basic and clinical study on jaw bone regeneration.
Oral and Maxillofacial Surgery 2. Basic and clinical study on treatment for oral precancer lesion.
3. Development of new dental implant therapy.
4. Basic and clinical study on jaw bone reconstruction and oral rehabilitation.
Prof.Yasuyuki Shibuya
5. Clinical study on oral care.
Plastic and reconstructive
Management of impaired wound healing, soft tissue reconstruction by adipocyte-derived stem cells,
surgerylymphedema and lymphatic regeneration
Prof. Kazuhiro Toriyama
Experimental Pathology andTumor Biology

Prof. Satoru Takahashi
Pathology and MolecularDiagnostics(TBA)

Research Description: We principally employ cell culture and genetically engineered rat models tounderstand the molecular characteristics of prostate cancers, and to explore their potential as
chemopreventive targets. Alternatively, the following themes are studied in subgroups.
・Clinicopathological analysis for development and progression of prostate, breast, and female
gynecologic tumor
・The potential of a gap junctional protein in experimental and human hepatocarcinogenesis
・Discovery of modifying effects against carcinogenesis and their molecular mechanisms by natural
products and compounds including health food products(TBA)

1. Pathophysiological roles of ion channels in inflammatory diseases
2. Role of ion channels in cancer and immunosuppressive cells under tumor microenvironment (cancer
therapy resistance, cancer stemness, and recruitment of immunosuppressive cells by chemokines)
Biosignaling and3. Regulation of ion channels and their regulators in osteoblast differentiation and bone-related diseases
Prof. Susumu Ohya
Regulation in
4. Molecular mechanisms of mechanotransduction in cardiac physiology and pathology
MedicalPathogenesis of virulent bacteria, such as group A streptococcus
Bacteriology
Sciences(Streptococcus pyogenes ),Analysis of the function and the expression of virulence-associated proteins of bacteria,Prof. Tadao Hasegawa
Development of novel strategies for the treatment of severe bacterial infectious diseases.
(1) Immune regulation using dendritic cells and regulatory T cells
Immunology(2) Cell based immune therapy using (1)(3) Inducing effective immune responses by breaking immune tolerance
Prof.Sayuri Yamazaki(4) Developing new molecular targeted immune therapy
1. Comprehensive genetic analysis of Epstein-Barr virus (EBV)-associated diseases
Virology
2. Comprehensive genetic analysis of rare cancers and inherited diseases
3. Genetic diagnosis of patients with undiagnosed diseases
Prof. Yusuke Okuno
4. Comprehensive detection of pathogens using next-generation sequencing
Comparative and Experimental We are are working on the following subjects through the generating genome-editing animals and thephenotypic analysess; (1) The effect of membranous proteins recycling pathway on the early
Medicinedevelopment of mammals, (2) Improvement of pregnancy rate by homeostatic and epigenetic analyses ofProf. Hisashi Oishi
reproductive aging.
Pharmacology-10-MajorSpecialized field of study

Research contents

Faculty member in charge

1) Mechanism of hypertrophic change of flavum in lumbar spinal stenosis. 2) Radio-hyperthermochemotherapy for malignant soft tissue tumors. 3) Pathophysiology of hip joint disorder in childhood. 4)
Orthopaedic Surgery
Regeneration of peripheral nerve using artificial nerve. 5) Biomechanical study of ACL injured knee andACL reconstructed knee. 6) Mechanism of pathogenesis in rheumatoid arthritis. 7) Effectiveness of drug
treatment and operative therapy in rheumatoid arthritis. 8) Basic and clinical research for throwingProf. Hideki Murakami
related shoulder and elbow injuries. 9) Regenerative medicine for post-traumatic bone and cartilage
defect. 10) Molecular research of pathogenesis and therapeutics in ischemic of osteonecrosis.
① The evaluation of motor and cognitive function using non-invasive methods and creating newneurorehabilitation based on the personalized functional disability ②Creating a novel personalized
Rehabilitation Medicine
rehabilitation system after total hip arthroplasty using wearable cyborg ③ Creating new gait
rehabilitation in parkinsonian syndrom using closed loop stimulation ④ prediction and adjust theappropriate rehabilitation ⑤A Nationwide Survey on the current state of rehabilitation ofProf. Yoshino Uekineurodegenerative disorders
Development of novel treatment using cognitive behavioral therapy, interpersonal therapy, and digital
Psychiatry and Cognitivetechnology for mood disorders, anxiety disorders, post-traumatic stress disorder, eating disorders, andBehavioral Medicine
cancer patients. Research on family intervention and family psychoeducation for mood disorders andschizophrenia. Development of intervention for developmental disabilities, truant children, and theirfamilies. Research on treatment optimization for refractory depression (mECT, TMS, etc.). Research inProf. Tatsuo Akechi
the areas of consultation liaison psychiatry including perinatal care, psycho-oncology, palliative
Biosignaling andmedicine, epileptology, student mental health, and community mental health s also being conducted.
Regulation in
Supprtive, Palliative and Psychosocial intervention for cancer patients with patient-public involvement;
Medical
Psycho-oncology
Survivorship care planning; Advance care planning; Communication; Collaborative care programs;
Sciences
Psycho-pediatric, AYA generation and geriatric oncology; Family and bereaved family support forProf. Maiko Fujimori
patients with cancer; Education for oncology staff, Implementation Science of digital mental health,(Cooperative graduate school) Cancer control research with Big data science.
Surgery of ischemic cerebrovascular disorder; molecular mechanism of brain lesion repair; molecularbiological study of the pathological condition of subarachnoid hemorrhage, hydrencephalus and increase
Neurosurgery
in intracranial pressure; development of a new method for basilar surgery, stereoencephalotomy andcerebrovascular surgery; development of a surgical treatment method for Parkinson’s disease;pathological analysis and development of treatment for diffuse brain injury; development of neuralProf. Mitsuhito Masefunction recovery by means of stem cell transfusion; development of operation assisting imaging
technology; development and introduction of a new functional brain surgery
Obstetrics and Gynecology
Prof. Mayumi Sugiura

Recurrent pregnancy loss, preimplantation genetic diagnosis; prenatal diagnosis and fetal therapy;
assisted reproduction technology; genital tumor development mechanism; genetic counselling; Birthcohort of the Japan Environment and Children's study.

Pathogenesis and treatment of neonatal brain injury, diagnosis and treatment of pediatricendocrinological disorders, Comprehensive management of congenital heart diseases, diagnosis andtreatment of pediatric malignancy, pathogenesis of pediatric liver diseases, pathogenesis of pediatricneurological disorders, genomic medicine in pediatrics, pediatric application of regenerative medicine,Prof. Shinji Saitoh
evaluation and management of developmental disabilities.
Our final goal is to elucidate molecular mechanisms underlying pathogenesis of neurocognitive disorders,
particularly Alzheimer's disease (AD) and related disorders, and to develop preventive or therapeutic
Neurocognitive Sciencestrategies for the disease. (1) elucidation of the role of chronic neuroinflammation (neuro-glial
interaction) associating disease development (2) understanding of the brain-peripheral interaction forpathogenesis of AD (3) understanding of the disease-disease interaction for acceleration of AD
Prof. Takashi Saito
pathogenesis.
Our research aims to elucidate the mechanisms underlying the initiation and progression of brain tumors
in both children and adults, and to identify new therapeutic target molecules based on these findings. We
Biodefense
Neuro-Oncology
are particularly focused on developing spontaneously occurring brain tumor mouse models that
System andrecapitulate human disease, and are working to uncover new cancer signals from a unique perspectiveComprehensivethat integrates developmental neurobiology, tumor biology, and genome functional studies. Additionally,
Medicalthrough pharmacological experiments using models with transplanted tumors from human patients, we
Sciences
Prof. Daisuke Kawauchi
are advancing research that bridges basic and clinical studies, in collaboration with international
partners.
Neurodevelopmental Disorder It has been revealed that genetic backgraound largely contributes to the pathogenesis of developmental
disorders, and many responsible genes have been identified. Our group has been studying molecular
Genetics
genetics of neurodevelopmental disorders, intellectural disabilities and epilepsy by identification of
responsible genes and .analyses of model mice. We are now trying to develop therapeutic approaches
Prof. Kazuhiro Yamakawa
including gene therapies.
Pediatrics and Neonatology-11-

MajorSpecialized field of study

Research contents

Faculty member in charge

Neurotoxicology

Prof. Masumi Suzui(1) Development of a screening method of potential carcinogens by using in silico toxicogenomics, risk
assessment of xenobiotics in foods and occupational or environmental exposure, development of abiomarker that predicts adverse side effects of medical drugs; (2) Molecular design and generation of a
new antitumor drug aiming at toxicity mitigation, in silico analysis of its anticancer activity and activity
analysis by using the wet system; (3) Development of an animal model that is highly sensitive to
carcinogenesis by using transgenic technology, analysis of molecular mechanism of carcinogenesis,
evaluation of extrapolative efficacy of the animal models to humans, development of a diagnostic

biomarker of cancer; （4）Studies on the intercellular interactions via exosomes; (5) Functional analysisof the intracerebral signal peptide
Our lab is interested in new neurons generated by neural stem cells in the adult brain. We are studying
Developmental andthe mechanisms for neuronal migration, maturation and survival in the physiological and pathological
Regenerative Neurobiology
conditions using a variety of in vitro and in vivo systems. We are also developing technologies toProf. Kazunobu Sawamotopromote migration and regeneration of brain cells.
1. Elucidation of neural mechanisms of learning and memory and emotion. Analysis of neural networks
Cognitive Function andby measurement and manipulation of neural activity in vivo and selective visualization of neural circuits.
Pathology *Endowed course
2. Elucidation of the pathophysiology of neurological and psychiatric disorders related to disruption ofProf. Hiroshi Nomura
memory and emotion. Development of novel therapeutic and preventive methods for these disorders.
1. Exploration of novel markers of diagnosis and treatment efficacy for digestive organ cancer, 2.
Development of diagnostic method and treatment using photodynamics for gastrointestinal cancer, 3.
Gastroenterology andDevelopment of novel treatment for inflammatory bowel disease, 4. Development of novel diagnostic
Metabolism
method and treatment for IgG4-related disease and autoimmune pancreatitis, 5. Development oftreatment using metallic stent for malignant stenosis of biliary and gastrointestinal tract, andmultidisciplinary opinion including dynamic standpoint, 6. Development of treatment for non-alcoholicsteatohepatitis, 7. Development of treatment for the prevention of hepatocarcinogenesis, 8. Viral andProf. Hiromi Kataoka
human genomic analysis in viral hepatitis, 9. Investigation of pathogenesis and exploration of novel
target molecules of treatment for diabetes mellitus, dyslipidemia, obesity and endocrine disease
・Chronic airway deceases (asthma, chronic cough, COPD and chronic airways
infection): epidemiology, disease concept, pathophysiology, genetic determinants, CT image analysis,
Biodefense
Respiratory Medicine, Allergy diagnosis and treatment.
System andand Clinical Immunology
・Lung cancer: molecular pathobiology, susceptibility to anticancer agents,and multicenter large-scale
Comprehensive
studies.
Medical・Respiratory infection（nontuberculous mycobacteriosis, pneumonia）:
Sciences
epidemiology, pathophysiology, CT image analysis, diagnosis and treatment.
・Interstitial lung diseases: pathophysiology, CT image analysis and treatment.
Prof. Akio Niimi
・Relationship of respiratory symptoms such as cough and gastroesophageal reflux disease.
・Connective tissue disorders: search of novel autoimmune molecules, pathophysiology analysis anddiagnosis using clinical samples, and treatment.
1. Development of early diagnosis algorithm and treatment for heart failure, 2. Development of Nagoya
City model for chronic heart failure treatment, 3. Development of 4D speckle tracking echocardiography,
Cardioangiology
4. Research on acute kidney injury in acute heart failure, 5. Development of intra-renal circulation
imaging system in heart disease, 6. national research of cardiac amyloidosis to develop a new diagnostic
system, 7. Development of a method to evaluate atrial histology and its application to the treatment of
atrial fibrillation, 8. Research on atrial function and heart failure, 9. Research on lipid abnormalities andProf. Yoshihiro Seo
diabetes-related to coronary artery disease, 10. Research on the significance of central artery pressure in
cardiovascular coupling.
1. Complications of chronic kidney disease, especially renal anemia and mineral bone disorders
Nephrology
2. Research on diabetic kidney disease and congestive kidney focusing on the kidney size
3. Research on acute kidney injury
Prof. Takayuki Hamano
4. Research on pathophysiology of cardiorenal syndrome
1. Clinical Neurology,espasially neurogenerative disease including Parkinson disease, Parkison-relateddisease, Alzheimer's disease, Lewy body dementia, Frontal tenporal lobe demantia.
Neurology
2. Development of radiological diagnostic biomarker for neurogenerative disease
3. Analysis for Alzheimer's pathogenesis from the perspective of hippocampal cholinergic
neurstimulating peptide (HCNP)
Prof. Noriyuki Matsukawa
4. Development of therapeutic agent for Alzheimer's disease by using new model mice
1. Dissection of molecular pathogenesis of hematopoietic neoplasms, identification of novel moleculartargets, exploration of biomarkers predicting for the efficacy and adverse events of molecular targeting
Hematology & Oncology
therapies, and mechanisms responsible for the drug resistance
2. Development of novel immune therapies against cancer with therapeutic antibodies or chimericantigen receptor T-cell (CAR-T) therapies
Prof. Shinsuke Iida
3. Planning and conducting preclinical studies and clinical trials against cancer-12-MajorSpecialized field of study

Research contents

Faculty member in charge
Anesthesiology and Intensive
Care Medicine

Prof. Kazuya Sobue
Radiology
Prof. Akio Hiwatashi
General Medicine & General
Internal Medicine
Biodefense
System andComprehensive Prof. Kei Miyazaki
MedicalSciences
Clinical Pharmaceutics
Prof. Yoko Hibi
Advancing Acute Medicine
Prof. Hiroshi SasanoProf. Tomonori Hattori
Emergency and Critical Care
Prof. Asako Matsushima
Occupational andEnvironmental HealthProf. Michihiro Kamijima
Public HealthProf. Sadao Suzuki
Forensic Medicine(TBA)
Community
Medicine,
Environmental Medical Education
Health Sciences
and Medical Prof. Osamu Takakuwa
Education
Medical Innovation
Prof. Takeshi Kamiya
Biostatistics and Health Data
ScienceProf. Kenichi Yoshimura
Infectious Diseases
Prof. Naoya Ito

1. Elucidation of the mechanisms of neurocognitive dysfunction in the perioperative period
2. Elucidation of the pathogenesis of central nervous system disorders caused by sepsis and developmentof treatment methods,
3. Elucidation of the pathogenesis of chronic pain and development of treatment methods
4. Elucidation of the mechanisms of chronic pain in the oral region and development of treatment
methods
5. Basic research on nutritional management for critically ill patients
6. Clinical research in the areas of anesthesia and intensive care
1. Research on advanced imaging modalities, 2. Development of new radiology service with artificial
intelligence, 3. Creation of new treatment in interventional radiology, 4. Optimization andstandardization of radiation treatment including proton beam therapy, 5. Clarification of the effect ofradiation with biology
Quantitative and qualitative research on the following topics. 1.Training of general practitioners/internal
medicine physicians (curriculum development, video review, interdisciplinary collaboration, etc.)
2.Promotion of ACP (Advance Care Planning) 3.The usefulness of medical interviews (training ofstandardized patients, etc.) 4.SDH (Social Determinants of Health) (COVID-19, medical access forforeign residents in Japan, etc.) 5.Development of a new concept of health (positive health) 6.National
survey, diagnosis, and development of treatment methods for rare diseases (SCLS etc) 7.Communitybased participatory research utilizing community health care centers (such as frailty prevention)
1. Analysis of risk factor of side effect on chemotherapy.
2. Efficacy evaluation of new therapeutic drug monitoring software of antibacterial agents.
3. Analysis of the relationship between urinary / kidney diseases and drugs and development of newtreatments.
4. Clinical research based on drug treatment issues, etc.
（Prof. Hiroshi Sasano） Breathing-circulation cooperation (heart rate, blood flow variability analysis,
physiology of respiratory sinus arrhythmia), the development of clinical devices (ultrasound-guided
puncture, oxygen administration), peripherally inserted central venous catheter, medical simulation
education.
（Prof. Tomonori Hattori）Venous blood gas and lactate studies, Research on sepsis pathology andendothelial-derived hyperpolarizing factor (EDHF), Research on frailty and emergency medicine,Research on lung damage caused by COVID-19, Research on Long COVID-19
Clinical study of sepsis and infection control.
Clinical study of trauma and critical care.
Study of disaster reduction and medicine
Stusy of helthcare art at emergency room(1) Risk assessment of environmental chemicals (research on their health effects, mechanisms of action,
exposure characterization), (2) Epidemiologic study on children's environmental health
The department specializes in epidemiology. The target outcome includes lifestyle-related diseases suchas cancer, diabetes mellitus, and metabolic syndrome, QOL, health status, and death. Using a statistical
approach, we discuss the relationship between these outcome and genetic and/or environmental factors
such as life styles, psychosocial factors, and genetic polymorphism including the interaction. We also
work on evaluation and comparison of diagnostic tests, clinical epidemiology and descriptive
epidemiology of intractable diseases.
(TBA)
Development of medical and healthcare education systems among multiple medical institutes.
Development of effective faculty developments for clinicians. Development and assessment for new
interprofessional education system.
1. Pathophysiology, epidemiology and new therapeutic strategies of functional gastrointestinal disorders
2. Methodiology and pedagogy of clinical studies 3. Basic studies on the mechanisms of visceralperception 4. Database studies on gastrointestinal and circulatory diseases 5. Pathophysiology and newtherapeutic strateries of heart failure 6. Clinical studies of emerging infectious diseases by mathematicalmodels 7. International studies of prevention and treatment on peuminia and ARDS
Development of new statistical methods in the medical field, research on biostatistical methodologies,
data science research as an applied field of statistics (e.g. data management, data collection design,
statistical analysis, interpretation, and communication methodologies), and research on methodologies
related to planning and conducting clinical research and trials as an applied field of biostatistics.
1. Antimicrobial stewardship program in hospitals and communities 2. Impact of infectious disease
consultation on patient outcomes 3. COVID-19 in immunocompromised patients 4. Clinical research ofdrug-resistant bacteria 5. Epidemiology of infectious diseases in post-travel patients-13-