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Keygen 17 Download version no. CALMAN 5 ENTHUSIAST KEYGEN 17 DOWNLOAD: interaction of cyclic AMP, Ca2+and ATP in the regulation of the TSH receptor in FRTL-5 cells. Forskolin stimulates the growth of FRTL-5 cells, but can act asan inhibitory hormone when adenosine 3',5'-cyclic monophosphate (cAMP) is elevated by adding theophylline. The effects ofthese agents are mediated, at least in part, by the thyrotropin receptor (TSH-R) which is expressed during growth in FRTL-5cells but is downregulated upon removal of cAMP-increasing agents. cAMP and ATP inhibit hormone-stimulated growth of
FRTL-5 cells, presumably by up-regulating the TSH-R. To determine whether the changes in the level of TSH-R are due toalteration of either activation or desensitization, we investigated whether the effects of these agents are independent of eachother. The effects of cyclic AMP, cAMP analogues and ATP on the levels of TSH-R were examined in the same experiments.
When cAMP or cAMP analogues were added to cells 30 min before TSH, cAMP, or ATP, the upregulation of the receptor was
not prevented. Similarly, when TSH was added 30 min before cAMP, cAMP analogues or ATP, the downregulation was notprevented. Forskolin and the ATP analog AMP 5-P(2) 5'-triphosphate also lowered the number of TSH-binding sites in FRTL-5cells. Together these studies suggest that the effects of f678ea9f9e
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Calman 5 Enthusiast Keygen 17 Ezizz Eine Woche Eintrge Ene