SAFETY DATA SHEET
Product Name: Klea™ 404A Revision: GHS04-3 Date: 02/2024 Page: 1 of 11

ACCORDING TO EC-REGULATIONS 1907/2006 (REACH), 1272/2008 (CLP) & 2015/830
SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product identifier
Product Name

Klea™ 404A

CAS No.

Not available.

EC No.

Not available.

REACH Registration No.

1,1,1-Trifluoroethane (HFC 143a): 01-2119492869-13-0003
Pentafluoroethane (HFC 125): 01-2119485636-25-0005
1,1,1,2-tetrafluoroethane (HFC 134a): 01-2119459374-33-0000

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified Use(s)Subject to Member State regulations, applicable uses are: refrigerant.

Uses Advised Against

Not known.

1.3 Details of the supplier of the safety data sheet
Manufacturer
Company Identification

Mexichem Fluor Japan Limited

Address of Manufacturer

Tennoz First Tower
2-4, Higashi-shinagawa 2-chome
Shinagawa-ku, Tokyo
JAPAN

Postal code

140-0002

Telephone:+81-3-5462-8661

FAX:+81-3-5462-8686

1.4 Emergency telephone number
Emergency Phone No.

For specialist advice in an emergency telephone +81-848-67-5232

SECTION 2: HAZARDS IDENTIFICATION
Low acute toxicity. High exposures may cause an abnormal heart rhythm and prove suddenly fatal. Very high atmosphericconcentrations may cause anaesthetic effects and asphyxiation. Liquid splashes or spray may cause freeze burns to skin andeyes.
2.1 Classification of the substance or mixture
Regulation (EC) No. 1272/2008 (CLP)

Press. Gas (Liq.) :Contains gas under pressure; may explode if heated.

2.2 Label elements
According to Regulation (EC) No. 1272/2008 (CLP)
Product Name

Klea™ 404A

Hazard Pictogram(s)GHS04
Signal Word(s)WarningSAFETY DATA SHEET
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Hazard Statement(s)H280: Contains gas under pressure; may explode if heated.

Precautionary Statement(s)P410+P403: Protect from sunlight. Store in a well-ventilated place.

2.3 Other hazards
None known.
2.4 Additional Information
None.
SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
Alternative names

R 404A

3.1 Substances
Not applicable.
3.2 Mixtures
HAZARDOUS INGREDIENT(S)%W/W

CAS No.

EC No.

Hazard Pictogram(s) and

1,1,1-Trifluoroethane (HFC 143a)

52

420-46-2

206-996-5

Pentafluoroethane (HFC 125)44354-33-6

206-557-8

GHS04 H280

1,1,1,2-tetrafluoroethane (HFC 134a)

4

811-97-2

212-377-0

GHS04 H280

Hazard Statement(s)GHS02 H220
GHS04 H280

SECTION 4: FIRST AID MEASURESThe first aid advice given for skin contact, eye contact, and ingestion is applicablefollowing exposures to the liquid or spray. See Also Section 11
4.1 Description of first aid measures
Inhalation

Remove patient from exposure, keep warm and at rest. Administer oxygen if
necessary. Apply artificial respiration if breathing has ceased or shows signs offailing. In the event of cardiac arrest apply external cardiac massage. Obtain
immediate medical attention.

Skin Contact

Thaw affected areas with water. Remove contaminated clothing. Caution: clothing
may adhere to the skin in the case of freeze burns. After contact with skin, wash
immediately with plenty of warm water. If irritation or blistering occur obtain medical
attention.

Eye Contact

Immediately irrigate with eyewash solution or clean water, holding the eyelids apart,

Ingestion

Unlikely route of exposure. Do not induce vomiting. Provided the patient isfor at least 10 minutes. Obtain immediate medical attention.
conscious, wash out mouth with water and give 200-300 ml (half a pint) of water todrink. Obtain immediate medical attention.
Further Medical Treatment

Symptomatic treatment and supportive therapy as indicated. Adrenaline and similar
sympathomimetic drugs should be avoided following exposure as cardiac arrhythmia
may result with possible subsequent cardiac arrest.

4.2 Most important symptoms and effects, both acute and delayedHigh exposures may cause an abnormal heart rhythm and prove suddenly fatal.
Very high atmospheric concentrations may cause anaesthetic effects andasphyxiation.

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4.3 Indication of any immediate medical attention and special treatment needed
Remove patient from exposure, keep warm and at rest. Administer oxygen if
necessary. Apply artificial respiration if breathing has ceased or shows signs offailing. In the event of cardiac arrest apply external cardiac massage. Obtain
immediate medical attention.
SECTION 5: FIREFIGHTING MEASURESThis refrigerant is not flammable in air under ambient conditions of temperature and pressure. Certain mixtures of thisrefrigerant and air when under pressure may be flammable. Mixtures of this refrigerant and air under pressure should be
avoided. Certain mixtures of HFCs and chlorine may be flammable or reactive under certain conditions.
5.1 Extinguishing media
Suitable Extinguishing media

As appropriate for surrounding fire.
Keep fire exposed containers cool by spraying with water.

Unsuitable extinguishing media

None.

5.2 Special hazards arising from the substance or mixture
Thermal decomposition will evolve very toxic and corrosive vapours (hydrogen
fluoride). Containers may burst if overheated.
5.3 Advice for firefighters
A self contained breathing apparatus and full protective clothing must be worn in fireconditions. See Also Section 8
SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures
Ensure suitable personal protection (including respiratory protection) during removalof spillages. See Also Section 8
6.2 Environmental precautions
Prevent liquid from entering drains, sewers, basements and workpits since thevapour may create a suffocating atmosphere.
6.3 Methods and material for containment and cleaning up
Provided it is safe to do so, isolate the source of the leak. Allow small spillages toevaporate provided there is adequate ventilation.
Large spillages: Ventilate area. Contain spillages with sand, earth or any suitable
adsorbent material. Prevent liquid from entering drains, sewers, basements andworkpits since the vapour may create a suffocating atmosphere.
6.4 Reference to other sections
See Also Section 8, 13.

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SECTION 7: HANDLING AND STORAGE

7.1 Precautions for safe handling
Avoid inhalation of high concentrations of vapours. Atmospheric levels should becontrolled in compliance with the occupational exposure limit. Atmosphericconcentrations well below the occupational exposure limit can be achieved by good
occupational hygiene practice. The vapour is heavier than air, high concentrations
may be produced at low levels where general ventilation is poor, in such cases
provide adequate ventilation or wear suitable respiratory protective equipment withpositive air supply. Avoid contact with naked flames and hot surfaces as corrosiveand very toxic decomposition products can be formed. Avoid contact between theliquid and skin and eyes. For correct refrigerant composition, systems should becharged using the liquid phase and not the vapour phase.
Avoid venting to atmosphere.
The fluorinated greenhouse gas R 404A may be supplied in returnable containers(drums/cylinders). The container contains fluorinated greenhouse gases covered by
the Kyoto Protocol. The fluorinated greenhouse gases in containers may not bevented to the atmosphere. Regulation (EU) No. 517/2014 of the European
Parliament and the Council on certain fluorinated greenhouse gases.
Process Hazards

Liquid refrigerant transfers between refrigerant containers and to and from systems
can result in static generation. Ensure adequate earthing. Certain mixtures of HFCs
and chlorine may be flammable or reactive under certain conditions. Care must be
taken to mitigate the risk of developing high pressures in systems caused by atemperature rise when liquid is trapped between closed valves or in cases wherecontainers have been overfilled.

7.2 Conditions for safe storage, including any incompatibilities
Keep in a well ventilated place away from fire risk and avoid sources of heat such as
electric or steam radiators. Avoid storing near to the intake of air conditioning units,
boiler units and open drains.
Storage temperature

Avoid high temperatures.

Storage life

Stable under normal conditions.

Incompatible materials

finely divided metals, alkali metals (sodium, potassium), alkaline earth metals(barium, magnesium), alloys containing more than 2% magnesium.

7.3 Specific end use(s)Subject to Member State regulations, applicable uses are: refrigerant.

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters8.1.1 Occupational Exposure Limits
SUBSTANCECAS No.

LTEL (8 hr TWA LTEL (8 hr TWA STEL (ppm)

1,1,1-Trifluoroethane (HFC

420-46-2

1000

COM

Pentafluoroethane (HFC 125) 354-33-6

1000

COM

1,1,1,2-tetrafluoroethane

1000

ppm)

STEL (mg/m³)

Note

mg/m³)

143a)
811-97-2

4240(HFC 134a)
RegionSourceEU

EU Occupational Exposure Limits

United Kingdom UK Workplace Exposure Limits EH40/2005 (Fourth edition, published 2020)
COM: The company aims to control exposure in its workplace to this limit.
8.2 Exposure controls
8.2.1. Appropriate engineering controls

Provide adequate ventilation. Atmospheric levels should be controlled in compliance8.2.2. Personal protection equipment

Wear suitable protective clothing and eye/face protection.

with the occupational exposure limit.
Eye Protection

Wear protective eyewear (goggles, face shield, or safety glasses).

Skin protection

Wear thermal insulating gloves when handling liquefied gases.

Respiratory protection

In cases of insufficient ventilation, where exposure to high concentrations of vapour
is possible, suitable respiratory protective equipment with positive air supply should
be used.

Thermal hazards

See above - Skin protection

8.2.3. Environmental Exposure Controls Prevent liquid from entering drains, sewers, basements and workpits since thevapour may create a suffocating atmosphere.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties
Appearance

Liquefied gas.
Colour: Colourless.

Odour

Slight ethereal

Odour thresholdNo information available.

pH

Not applicable.

Melting point/freezing point

No information available.

Initial boiling point and boiling range-47.2 to -46.4°C (boiling range)

Flash Point

Not applicable.

Evaporation rate

Not applicable.

Flammability (solid, gas)

Non-flammable.

Upper/lower flammability or explosive

Not applicable.

limits
Vapour pressure

8270 mm Hg @ 20°C

Vapour Density (Air=1)

3.42 at bubble point temperatureDensity (g/ml)

1.06 @ 20°C

Relative density

No information available.

Solubility(ies)

Solubility (Water) : Insoluble.

Partition coefficient: n-octanol/water

No information available.

Auto-ignition temperature

No information available.

Decomposition Temperature (°C)

No information available.

Viscosity

Not applicable.

Explosive properties

Not explosive.

Oxidising properties

Not oxidising.

Solubility (Other) : Soluble in: Alcohols, Chlorinated solvents, esters.

9.2 Other information
None.
SECTION 10: STABILITY AND REACTIVITY

10.1 Reactivity
See Section: Possibility of hazardous reactions
10.2 Chemical Stability
Stable under normal conditions.
10.3 Possibility of hazardous reactions

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Certain mixtures of HFCs and chlorine may be flammable or reactive under certain
conditions. Incompatible materials: finely divided metals, magnesium and alloys
containing more than 2% magnesium. Can react violently if in contact with alkali
metals and alkaline earth metals - sodium, potassium, barium.
10.4 Conditions to avoid
Avoid high temperatures.
10.5 Incompatible materials
finely divided metals, alkali metals (sodium, potassium), alkaline earth metals(barium, magnesium), alloys containing more than 2% magnesium.
10.6 Hazardous decomposition productshydrogen fluoride by thermal decomposition and hydrolysis.
SECTION 11: TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects
Acute toxicity - Ingestion

Highly unlikely - but should this occur freeze burns will result.

Acute toxicity - Skin Contact

Unlikely to be hazardous by skin absorption.

Acute toxicity - Inhalation

HFC 143a: LC50 (rat) (4 hrs) > 600000 ppm (2060000 mg/m³)
HFC 125: LC50 (rat) (4 hrs) > 800000 ppm (3928000 mg/m³)
HFC 134a: LC50 (rat) (4 hrs) > 500000 ppm (2080000 mg/m³)
High exposures may cause an abnormal heart rhythm and prove suddenly fatal. Veryhigh atmospheric concentrations may cause anaesthetic effects and asphyxiation.

Skin corrosion/irritation

Liquid splashes or spray may cause freeze burns.

Serious eye damage/irritation

Liquid splashes or spray may cause freeze burns.

Skin sensitization data

It is not a skin sensitiser.

Respiratory sensitization data

Not classified.

Germ cell mutagenicity

No evidence of mutagenic effects.

Carcinogenicity

It is unlikely to present a carcinogenic hazard to man.
HFC 134a: A lifetime inhalation study in rats has shown that exposure to 50000ppm
resulted in benign tumours of the testis. The increased tumour incidence wasobserved only after prolonged exposure to high levels, and is considered not to be of
relevance to humans occupationally exposed to HFC 134a at or below theoccupational exposure limit.

Reproductive toxicity

HFC 143a, HFC 125, HFC 134a: Studies in animals have shown that repeatedexposures produce no teratogenic effects.

Lactation

Not classified.

STOT - single exposure

Not classified.

STOT - repeated exposure

Not classified.

Aspiration hazard

Not applicable.

11.2 Other information
Respiratory irritation
Repeated dose toxicity

Non-irritant.
HFC 143a: An inhalation study in animals has shown that repeated exposures
produce no significant effects (40000ppm in rats).
HFC 125: An inhalation study in animals has shown that repeated exposures
produce no significant effects (50000ppm in rats).

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HFC 134a: An inhalation study in animals has shown that repeated exposures
produce no significant effects (50000ppm in rats).

SECTION 12: ECOLOGICAL INFORMATION

12.1 Toxicity
The product is predicted to have low toxicity to aquatic organisms.
Toxicity - Aquatic invertebrates

Low toxicity to aquatic invertebrates.

Toxicity - Fish

Low toxicity to fish.

Toxicity - Algae

Low toxicity to algae.

Toxicity - Sediment Compartment

Not classified.

Toxicity - Terrestrial Compartment

Not classified.

Environmental Fate and Distribution

High tonnage material produced in wholly contained systems. High tonnage material
used in open systems. Gas.

12.2 Persistence and Degradation
HFC 143a: Decomposed slowly in the lower atmosphere (troposphere). Atmospheric
lifetime is 52 years.
HFC 125: Decomposed slowly in the lower atmosphere (troposphere). Atmospheric
lifetime is 29 years.
HFC 134a: Decomposed comparatively rapidly in the lower atmosphere(troposphere). Atmospheric lifetime is 14 years.
R 404A: Does not influence photochemical smog (i.e. is not a VOC under the termsof the UNECE agreement). Does not deplete ozone. Has a Global Warming
Potential (GWP) of 3922 (relative to a value of 1 for carbon dioxide at 100 years)
according to Annex I of Regulation (EU) No. 517/2014 on certain fluorinatedgreenhouse gases. Values in Annex I are taken from the fourth assessment report(AR4) of the Intergovernmental Panel on Climate Change.
United Nations Framework Convention on Climate Change (UNFCCC) reporting
GWP is 3260.
12.3 Bioaccumulative potential
The product has no potential for bioaccumulation.
12.4 Mobility in soil
Not applicable.
12.5 Results of PBT and vPvB assessment
Not classified as PBT or vPvB.
12.6 Other adverse effects
None known.

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Effect on Effluent Treatment

Discharges of the product will enter the atmosphere and will not result in long term
aqueous contamination.

SECTION 13: DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods
Best to recover and recycle. If this is not possible, destruction is to be in an
approved facility which is equipped to absorb and neutralise acid gases and othertoxic processing products.
13.2 Additional Information
Disposal should be in accordance with local, state or national legislation.

SECTION 14: TRANSPORT INFORMATION

14.1 UN number
UN No.

3337

14.2 UN proper shipping nameUN proper shipping name

REFRIGERANT GAS R 404A

14.3 Transport hazard class(es)ADR/RID
ADR/RID Class

2.2

IMDG
IMDG Class

2.2

ICAO/IATA
ICAO/IATA Class

2.2

Labels

14.4 Packing group
Packing group

Not applicable.

14.5 Environmental hazards
Environmental hazards

Not classified as a Marine Pollutant.

14.6 Special precautions for user
Special precautions for user

Not known.

14.7 Transport in bulk according to Annex II of Marpol and the IBC CodeTransport in bulk according to Annex II of Not applicable.
Marpol and the IBC CodeSECTION 15: REGULATORY INFORMATION

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
European Regulations
EC Classification

According to Regulation (EC) No. 1272/2008 (CLP)
Gases under pressure - liquefied gas

SAFETY DATA SHEET
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Special Restrictions:

The fluorinated greenhouse gas R 404A may be supplied in returnable containers(drums/cylinders). The container contains fluorinated greenhouse gases covered by
the Kyoto Protocol. The fluorinated greenhouse gases in containers may not bevented to the atmosphere.
Regulation (EU) No. 517/2014 of the European Parliament and the Council on
certain fluorinated greenhouse gases.
Directive 2006/40/EC of the European Parliament and the Council relating toemissions from air-conditioning systems in motor vehicles and amending Council
Directive 70/156/EC.

15.2 Chemical Safety Assessment
A chemical safety assessment is not required under REACH.
SECTION 16: OTHER INFORMATION
The following sections contain revisions or new statements:

1-16

LEGEND
Hazard Statement(s)H220: Extremely flammable gas.
H280: Contains gas under pressure; may explode if heated.

Acronyms

ADR : European Agreement concerning the International Carriage of Dangerous
Goods by Road
CAS : Chemical Abstracts Service
CLP : Regulation (EC) No 1272/2008 on classification, labelling and packaging of
substances and mixtures
EC : European Community
IATA : International Air Transport Association
IBC : Intermediate Bulk Container
ICAO : International Civil Aviation Organization
IMDG : International Maritime Dangerous Goods
LTEL : Long term exposure limit
PBT : Persistent, Bioaccumulative and Toxic
REACH : Registration, Evaluation, Authorisation and Restriction of Chemicals
RID : Regulations concerning the International Carriage of Dangerous Goods by RailSTEL : Short term exposure limit
STOT : Specific Target Organ Toxicity
UN : United Nations
vPvB : very Persistent and very Bioaccumulative

Disclaimers

Information in this publication is believed to be accurate and is given in good faith,but it is for the User to satisfy itself of the suitability for its own particular purpose.
Accordingly, Mexichem UK Limited gives no warranty as to the fitness of the Productfor any particular purpose and any implied warranty or condition (statutory or

SAFETY DATA SHEET
Product Name: Klea™ 404A Revision: GHS04-3 Date: 02/2024 Page: 11 of 11

otherwise) is excluded except to the extent that such exclusion is prevented by law.
Freedom under Patent, Copyright and Designs cannot be assumed. Klea™ is atrademark, the property of Mexichem SAB de C.V.
Mexichem UK Limited is Registered in England No 7088219. Registered Office The
Heath Business & Technical Park, Runcorn, Cheshire WA7 4QX.
© Mexichem UK Limited 2016.