Multiscale Brain/
Molecular and Cellular Cognition Society Asia

Constructive understanding of multiscale dynamism of brain and itsdisorders
Date: June 27-28, 2022
Venue: Ito Hall, Tokyo Univ.
Zoom meeting ID：874 0536 0524, Pass code：651613

Organizers
Satoshi Kida (Tokyo Univ.)
Yasunori Hayashi (Kyoto Univ.)
SupportMEXT Grant-in-Aid for Scientific Research on Innovative Areas“Constructive understanding of multi-scale dynamism ofneuropsychiatric disorders”
SECOM Science and Technology Foundation
The Uehara Memorial Foundation
The NOVARTIS Foundation (Japan) for the Promotion of ScienceContact
Satoshi Kida: akida@g.ecc.u-tokyo.ac.jp
Yasunori Hayashi: yhayashi-tky@umin.ac.jp

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Access to Ito Hall, Tokyo Univ.
From Narita or Haneda Airport to Tokyo

AirportTrain lines and major destinations in downtown Tokyo
JR Line: Narita Express to Tokyo, Shinagawa or Shinjuku Stations

Narita Airport

Keisei/Hokuso Sky Access Line: Skyliner to Nippori or Ueno
Stations

Haneda Airport Keikyu Airport Line to Shinagawa Station
Do not take a taxi. It is too far away and can cost >US$200.
After arriving downtown Tokyo, please change to local line (JR or subway) to reachyour hotel.
Venue and Online Participation
Ito Hall is located on Hongo Campus Tokyo Univ..
7-3-1, Hongo, Bunkyou-ku, Tokyo 113-0033+81-3-5841-0779 (international) or 03-5841-0779 (within Japan)(for GPS: 35.710N, 139.760E)
Hongo-sanchome Station (Marunouchi and Oedo Lines) is the closest station.
https://u-tokyo-acjp.zoom.us/j/87405360524?pwd=RFRma1kwczRkN245MFRyQTlpZFovdz09
ID：874 0536 0524
Pass code：651613

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For simplicity, not all stations are listed.

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Symposium Schedule
June 27, 2022
9:00–9:10

Opening Remarks – Chair of Multiscale Brain
Dr. Akiko Hayashi-Takagi (RIKEN CBS, Japan)

9:10–9:15

Opening Remarks – MCCS Asia
Dr. Satoshi Kida (Univ Tokyo, Japan)<Session 1> Chairman; Dr. Satoshi Kida (Univ Tokyo, Japan)
Sponsored by SECOM
9:15–9:40
Dr. Alicia Che (Yale Univ, USA)
Role of GABAergic interneurons in mediating early life experiences andimplications in psychiatric illnesses
9:40–10:05
Dr. Yasunori Hayashi (Kyoto Univ, Japan)
Online- and offline-LTP underlying long-term fear memory
10:05–10:30
Dr. Jelena Radulovic (Albert Einstein Med Coll, USA, online)
Primary cilia control the formation of lasting memories
10:30–10:45<Session 2>

Coffee Break
Chairman; Dr. Timothy W. Bredy (Univ Queensland, Australia)

10:45–11:10
Dr. Gustavo Turecki (McGill Univ, Canada, online)
The depressed brain at single-cell resolution
11:10–11:35
Dr. Satoshi Kida (Univ Tokyo, Japan)
Potential roles of cAMP signaling pathway in PTSD
11:35–12:00
Dr. Tadafumi Kato (Juntendo Univ, Japan, online)
Possible roles of paraventricular thalamic nucleus in bipolar disorder
12:00–13:00<Session 3>

Lunch Break
Chairman; Dr. Tomoyuki Furuyashiki (Kobe Univ, Japan)

13:00–13:25
Dr. Kanzo Suzuki (Vanderbilt, USA)
Synaptic mechanisms underlying rapid antidepressant action
13:25–13:50
Dr. Anatol Kreitzer (UCSF, USA)
Modulation of dopamine signaling by internal needs
13:50–14:15
Dr. Weidong Li (Shanghai Jiao Tong Univ, China)
Desipramine rescues memory deficits in mouse model of Kabuki syndrome
14:15–14:25

Coffee Break4

<Session 4>

Chairman; Dr. Ted Abel (Univ Iowa, USA)

14:25–14:50
Dr. Takanobu Nakazawa (Tokyo Univ. Agri. Japan)
Modelling psychiatric disorders with patient iPSC-derived neurons andmouse disease models
14:50–15:15
Dr. Zhihua Gao (Zhejiang Univ, China, online)
Oxytocin and emotional control
15:15–15:40
Dr. Akiko Hayashi (RIKEN CBS, Japan)
Multi-scale synaptic analysis for schizophrenia
15:40–15:50<Session 5>

Coffee Break
Chairman; Dr. Thomas McHugh (RIKEN CBS, Japan)

15:50–16:15
Dr. Mazen Kheirbek (UCSF, USA)
Representing rewarding and aversive experiences in hippocampal circuits
16:15–16:40
Dr. Juan Song (Univ North Carolina, USA)
Hypothalamic modulation of adult hippocampal neurogenesis and its
functional implication16:40–17:05
Dr. Ted Abel (Univ Iowa, USA)
Endoplasmic reticulum chaperone genes encode effectors of long-termmemory<Poster Session>
17:05–19:00

See p8- for titles

5June 28, 2022
9:00–9:05

Dr. Satoshi Kida
General Information<Session 6> Chairman; Dr. Akiko Hayashi-Takagi (RIKEN CBS, Japan)
9:05–9:30
Dr. Takeshi Imai (Kyushu Univ, Japan)
Cortical development during adolescence
9:30–9:55
Dr. Shusaku Uchida (Kyoto Univ, Japan)
Constructive understanding of the mechanisms underlying psychosocial
stress-induced behavioral heterogeneity
9:55–10:20
Dr. Tomoyuki Furuyashiki (Kobe Univ, Japan)
Inflammatory mechanisms of stress and depression
10:20–10:35<Session 7>

Coffee Break
Chairman; Dr. Josh Johansen (RIKEN CBS, Japan)

10:35–11:00
Dr. Matthew Girgenti (Yale Univ, USA)
Integrating single cell genomics to understand stress disorder
11:00–11:25
Dr. Atsushi Kasai (Osaka Univ, Japan)
Claustral ensemble for stress-induced anxiety responses
11:25–11:50
Dr. Takuya Sasaki (Tohoku Univ, Japan)
Hippocampal memory mechanisms underlie stress-induced psychiatricdisease11:50–13:00<Session 8>Lunch Break
Chairman; Dr. Paul Frankland (Hosp Sick Kids, Canada)

13:00–13:25
Dr. Takashi Kitamura (Univ Texas, USA)
Role of Eph/Ephrin signals on anatomical and functional modules in medial
entorhinal cortex
13:25–13:50
Dr. Hyungju Park (Korea Brain Res Inst, Korea, online)
Regulation of learning and memory by astrocytic synapse pruning
13:50–14:15
Dr. Gisella Vetere (ESPCI Paris, France)
Decoding memory formation and stabilization in mice
14:15–14:25

Coffee Break<Session 9>

Chairman; Dr. Takashi Kitamura (Univ Texas, USA)

14:25–14:50

Dr. Kobi Rosenblum (Univ Haifa, Israel, online)
6Differential cell specific regulation of protein synthesis control different
neuronal and behavioral processes
14:50–15:15
Dr. Paul Frankland (Hosp Sick Kids, Canada)
The supramammillary nucleus integrates environmental signals to modulate
mood and cognition via hippocampal neurogenesis
15:15–15:40
Dr. Yong-Seok Lee (Seoul Natl Univ, Korea)
Role of NAc-projecting infralimbic neurons in social recognition
15:40–15:50<Session 10>

Coffee BreakChairman; Dr. Yasunori Hayashi (Kyoto Univ)

15:50–16:15
Dr. Eric Klann (New York Univ. USA, online)
Cell type-specific and local translation in memory
16:15–16:40
Dr. Gemma Modinos (King's Coll London, UK, online)
Translational approaches to the role of GABAergic dysfunction invulnerability for psychosis
16:40–17:05
Dr. Justin Lee (Inst Basic Sci, Korea, online)
Reactive astrocytes as the cause of Alzheimer's disease
17:05–

Closing Remarks
Dr. Hiroyuki Nawa (Wakayama Med. Univ, Japan)

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<Poster Session>
1. Cerebello-thalamo-prefrontal circuits responsible for cognitive dysfunctionin psychiatric disorders
Shinichiro Tsutsumi and Akiko Hayashi-Takagi
RIKEN CBS
2. Distorted neurocomputation by heavily-weighted synapses in mental
disorders
Kisho Obi-Nagata 1,2, Noritsu Suzuki 1,2, Matthew L. MacDonald 3, Kenneth N. Fish 3,
Kenichi Nagahama 4,5, Tsukasa Okimura 6,7, Shoji Tanaka 7, Masanobu Kano 4,5,
Robert A. Sweet 3, and Akiko Hayashi-Takagi 1,2
1. Laboratory for Multi-scale Biological Psychiatry, RIKEN CBS
2. Gunma Univ. Grad. Sch. Med.
3. Dept. Psychiatry, Neurology, Statistics, and Neurobiology, Translational
Neuroscience Program, Univ. of Pittsburgh, Sch. Med.
4. Dept. Neurophysiol., Grad. Sch. Med., Univ. Tokyo
5. International Res. Cntr. Neurointelligence (WPI-IRCN), Univ. Tokyo
6. Dept. Neuropsychiatry, Keio Univ. Sch. Med.
7. Dept. Inform. Comm. Sci., Sophia Univ.
3. Brain-Metabolic axis: Molecular mechanism of exacerbated depression-likebehaviors in a diabetes mellitus model
Yusuke Temma1,2, Ryuhei Miyake1,2, Kisho Obi-Nagata1,2, Yuta Katayama3, Hideo
Hagihara4, Tsuyoshi Miyakawa4, Keiichi I. Nakayama3, and Akiko Hayashi-Takagi1
1 Lab for Multi-scale Biological Psychiatry, RIKEN CBS
2 Gunma Univ. Grad. Sch. Med., Gunma Univ.
3 Dept. Mol. Cell. Biol., MiB, Kyushu Univ.,
4 Div. Systems Med. Sci., ICMS, Fujita Health Univ.
4. Region- and proficiency-specific synaptic potentiation in the prefrontal
cortex during learning of normal and compulsive operant behavior
Nozomi Asaoka, Yasunori Hayashi
Dept. Pharmacol., Grad. Sch. Med., Kyoto Univ.
5. The role of CA2 in organizing hippocampal network dynamics
Hongshen He, Yi Wang, Thomas J. McHugh.
RIKEN CBS
6. Establishment of methods to study the development of higher-ordercognition in mice
Eichi Toyoizumi1,2, Tomomi Shimogori1, Kazuo Okanoya2, & Thomas McHugh1
1. RIKEN CBS
2. Univ. Tokyo
7. Differential effect of midbrain-projecting lateral hypothalamic neurons on
aggressive behavior in male mice.
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Koshiro Mitsui1, Aki Takahashi2
1. Neurosci. Program, Univ. Tsukuba
2. Fac. Human Sci., Univ. Tsukuba
8. Neuronal correlates of reward-related facial expressions in primary motorcortex
Wanru Li1,2, Takashi Nakano3, and Takayuki Yamashita1
1. Dept. Physiol., Fujita Health Univ. Sch. Med.
2. Dept. Neural Regulation, Grad. Sch. Med., Nagoya Univ.
3. Dept. Comp. Biol., Fujita Health Univ. Sch. Med.
9. Distinct downstream targets of the medial prefrontal cortex underlie discrete
antidepressant responses to ketamine
Ryota Shinohara1,2, Brendan D Hare2, Rong-Jian Liu2, Jin Hua Li2, Xiao-Yuan Li2,Catharine H Duman2, Ralph J DiLeone2, Ronald S Duman2
1. Div. Pharmacol, Grad Sch Med, Kobe Univ, Kobe, Japan
2. Dept. Psych., Yale Sch Med, New Haven, USA
10. Altered neuronal activity of the claustrum by stress exposure
Masato Tanuma1, Keita Miyaji1, Jin Ohkubo1, Hiroshi Nomura2, Hitoshi Hashimoto1,36, Atsushi Kasai1
1. Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., Osaka
2. Dept. Cog. Function Pathol., Inst. Brain Sci., Nagoya City Univ. Grad. Sch. Med.
Sci, Nagoya, Japan
3. United Grad. Sch. Child Dev., Osaka Univ., Osaka, Japan
4. Inst. Datability Sci., Osaka Univ., Osaka, Japan
5. Inst. Open Transdisciplinary Res. Initiatives, Osaka Univ., Osaka, Japan
6. Dept. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ., Osaka, Japan
11. Hippocampal-entorhinal projections are differently organized between
medial and lateral entorhinal cortex in rodents
Shinya Ohara1,2, Menno P. Witter1,2, Ken-Ichiro Tsutsui1
1. Tohoku Univ. Grad. Sch. Life Sciences, Sendai.
2. Kavli Inst. Systems Neurosci., NTNU.
12. Autism in a dish: ES cell models of autism with copy number variations
reveal cell-type-specific vulnerability
Jun Nomura, Toru Takumi
Kobe Univ. Sch. Med.
13. Neuronal population regulating fear and extinction in mPFC
Rie Ishikawa, Satoshi Kida
Dept. Applied Biol. Chem, Univ. Tokyo
14. Enhancement of memory formation and retrieval by essential amino acidhistidine

9Tamau Kawashima1., Nene Kabayama2, Yuki Odagiri2, Toshiyuki Tanimizu1, RieIshikawa1, Satoshi Kida1
1. Dept. Applied Biol. Chem, Univ. Tokyo
2. Tokyo Univ. Agr.
15. Brain networks centered on prelimbic of mPFC for a novel food memory
Yudai Fukuyama, Satoshi Kida
Dept. Applied Biol. Chem, Univ. Tokyo
16. Establishment of a mouse model to detect food devaluation specific toingested foodAyumu Yoshida, Satoshi Kida
Dept. Applied Biol. Chem, Univ. Tokyo
17. Spontaneous recovery of contextual fear memory after extinction shows
similar hippocampal dependency as recent memory
Hotaka Fukushima1, Takanori Kawamura1, Satoshi Kida1,2
1. Dept. Biosci., Fac. Life Sci., Tokyo Univ. Agri.
2. Grad. Sch. Agr. Life Sci., Univ. Tokyo
18. Time-of-day dependent impairment of hippocampal memory retrieval in AD
model mice micro-infused Amyloid Beta 42 into the dorsal hippocampus.
James Borg, Satoshi Kida
Dept. Biosci., Fac. Life Sci., Tokyo Univ. Agri.
Note to presenters:
The size of poster board is W 90 cm x H 240 cm.
Please post your poster by 17:00 Jun. 27.

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P r e v e n t i o n m e a s u r e s a ga i n s t C O V I D - 1 9

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