CURRICULUM VITAE

GREGG A. HOWE
ADDRESSMSU-DOE Plant Research Lab, 4275 Molecular Plant Sciences, Michigan State University,
East Lansing, MI 48823
Tel: 517-355-5159; Email: howeg@msu.edu
https://prl.natsci.msu.edu/people/faculty/gregg-howe/
EDUCATION
1979 - 1983
1984 - 1987
1987 - 1993

East Carolina University, Greenville, NC. B.A., Biology
East Carolina University, Greenville, NC. M.Sc., Biology
University of California, Los Angeles, CA. Ph.D., Biology
Dissertation title: Biochemical and Genetic Analysis of Plastidic c-type
Cytochrome Biosynthesis in Chlamydomonas reinhardtii. (Dr. Sabeeha
Merchant, research advisor)

POSITIONS
1986 - 1987

Research Chemist, Plant Molecular Biology Group, Standard Oil of Ohio,
Cleveland, OH
1987
Research Assistant, Agricultural Research Biotechnology Unit, CIBAGEIGY, Research Triangle Park, NC
1993 - 1997
Postdoctoral Fellow, Institute of Biological Chemistry, Washington State
University, Pullman, WA (Dr. Clarence Ryan, research advisor)
1997 - 2003
Assistant Professor, MSU-DOE Plant Research Laboratory and Departmentof Biochemistry and Molecular Biology, Michigan State University, East
Lansing, MI
2003 - 2007
Associate Professor, MSU-DOE Plant Research Laboratory and Departmentof Biochemistry and Molecular Biology, Michigan State University, East
Lansing, MI2007 - present Professor, MSU-DOE Plant Research Laboratory and Department ofBiochemistry and Molecular Biology, Michigan State University, East
Lansing, MI
2013 – 2022
Project Lead of “Building and Operating the Biological Solar Panel”
research theme, core grant to the MSU-DOE Plant Research Laboratory2016 – present Founding Member, Plant Resilience Institute, Michigan State University
HONORS, AWARDS, AND FELLOWSHIPS
1984-1985
1985
1985
1987-1990

Burroughs Wellcome Research Fellowship
Mary Poston Award (presentation of paper)
James S. McDaniel Award (scholarship)
USDA Doctoral Research Fellowship1

1991-1992
1992-1993
1994-1997
1994-1997
1998-2003
2010
2010
2012
2014-2022
2016
2017
2017
2017
2020
2022

University of California Biotechnology Research Fellowship
Ursula Mandel Dissertation Year Fellowship
National Research Service Award (NRSA), National Institutes of HealthLife Sciences Research Foundation Fellowship (declined)
NIH FIRST grant award
MSU Distinguished Faculty Award
College of Natural Science Distinguished Faculty Award
Fellow of AAASHighly Cited Researcher (Thomson Reuters/Clarivate)
MSU Foundation Professor
MSU Innovation of the Year
Fellow of American Society of Plant Biologists AwardMSU Distinguished Professor
National Academy of Sciences, Member
US-Japan Fulbright Scholar

PROFESSIONAL SOCIETIESAmerican Society of Plant Biologists
American Association for the Advancement of Science
PROFESSIONAL ACTIVITIES
Editorial Boards
2005-20162004-2006
2006-2008
2008

Monitoring Editor, Plant Physiology
Member of the Advisory Board, The Plant Journal
Member of the Editorial Board, Molecular Plant Pathology
Co-editor of a Special Issue of Plant Physiology on “Plant Interactions with
Arthropod Herbivores”, 2008
2015
Guest Editor, Annual Review of Plant Biology
2012-2019
Guest Editor, Proc Natl Acad Sci USA
2017-present Section Head of Plant-Biotic Interactions, Faculty of 1000 (F1000)
Committees for Professional Societies
2005-2008
2021

Early Career Award Committee, American Society for Plant Biologists
Selection Committee, NAS Prize in Food and Agriculture Sciences

Grant Panels
1998
1999
2009
2011-20132015

Member, DOE Division of Energy Biosciences Grant Panel
Member, USDA/NRICGP Strengthening Grant Panel
Member, USDA/AFRI Arthropod & Nematode Suborganismal Biology andTools, Resources and Genomics Program
Ad hoc member, Cell Signaling and Regulatory Systems Study Section, NIH
Member, Strategic Partnership Grant Panel, MSU

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2016
2017
2020
2020
2022

Chair, Strategic Partnership Grant Panel, MSU
Member, DOE Division of Basic Energy Sciences
Member, NSF IOS Plant Biotic Interactions Panel
Review Team Member, DOE Division of Basic Energy Sciences
Member, NSF IOS/USDA NIFA Panel

OUTREACH
Host high school student for summer internship (1999)
Co-Chaired PRL CHOICES Day (Complete and Honest Information about Careers inScience), 2003; 2009
Faculty participant in MSU Plant Genomics Summer Research Program
http://plantgenomics.msu.edu/. Hosted and mentored a high school teacher (Carol Edwards,
2007-2008); Adar Zemin (summer, 2009); Jonathan Terrain (Iraq war veteran; summer2010); Kayla Moses (summer, 2014); Nicole Haddad (summer, 2016); Ryan Humphrey(2017)
Organized/chaired “Jasmonate signaling” and “Plant-herbivore Interactions” minisymposia,
American Society of Plant Biologists Annual Meeting, Merida, MX
Trained graduate student (Missy Smith, UC Riverside) in LC-MS as part of NSF IGERT
Program
Co-organizer of Inaugural Symposium on Plant Biotechnology for Health and Sustainability,
Michigan State University, October 2012, October 2013, October 2015
Hosted Brazilian Exchange student in Science Without Borders Program (Dalton de Oliveira
Ferreira, 2014 – 2015)
Hosted Brazilian Exchange student in Science Without Borders Program (Miriam Pimentel,
2015)
Seeds of Science Program in Plant-Insect Interactions, 4H MSU Children’s Garden (Local
Elementary School students). 2015-2018
INVITED CONFERENCE PRESENTATIONS & RESEARCH SEMINARS
1990
1992
1995
1996
1997
1998

Fourth International Conference on the Cell and Molecular Biology ofChlamydomonas. Delevan, WI
Fifth International Conference on the Cell and Molecular Biology ofChlamydomonas. Pacific Grove, CA“Plant Biochemistry 1995”. Washington State University, Pullman, WA
Institut de Biologie et de Physiologie végétales, Université de Lausanne, Switzerland
Conference on the Molecular Biology of Tomato. Berkeley, CA
Biology of Proteolysis. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Plant Biochemistry 1997. Washington State University, Pullman, WA
Department of Biology, University of Utah, Salt Lake City, UTNational Academy of Sciences/American Society of Plant Physiologists Symposium
on “Frontiers in Plant Biology,” Amherst, MA
Joint Annual Meeting, American Phytopathological Society and EntomologicalSociety of America, Las Vegas, NV
Department of Entomology, Michigan State University, East Lansing, MI

3

1999
2000
2001

2002
2003

2004
2005

2006

2007
2008

2009

Department of Biological Sciences, Western Michigan University, Kalamazoo, MI“Plant Biochemistry 1999.” Washington State University, Pullman, WA
Genetics and CMB Annual Retreat, MSU, Lake Higgins, MI
Cayman Chemical Company, Ann Arbor, MI
Dept of Horticulture/Crop and Soil Science, Michigan State Univ, East Lansing, MI
Michigan Life Science Corridor Conference, Novi, MI
1st IOBC Conference on Induced Resistance in Plants against Insects and Diseases,
Wageningen, The Netherlands
Department of Biological Sciences, University of South Carolina, Columbia, SC“Plant Biochemistry 2001,” Washington State University, Pullman, WA
Midwest Cytochromes P450 Symposium, West Lafayette, IN
Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, AR
Department of Cellular and Molecular Biology, UCLA, Los Angeles, CA
Dow AgroSciences, Indianapolis, IN
Department of Biology, University of Michigan, Ann Arbor, MI
Department of Plant Sciences, University of Arizona, Tucson, AZ
Institute for Plant Physiology and Biotechnology, University of Hohenhein, Stuttgart,
Germany
International Meeting on “Intra- and Intercellular Communication in Plants”, Halle,
Germany
American Society of Plant Biologists Annual Meeting, Orlando, FL
Entomological Society of America Annual Meeting, Salt Lake City, UT
Biology Department, Calvin College, Grand Rapids, MI
Plant Gene Expression Center, USDA, Albany, CA
Department of Plant Biology, University of California at Davis, Davis, CA
American Society of Plant Biologists Annual Meeting, Seattle, WA“Regulatory Oxylipins”, Lausanne, Switzerland
Department of Biochemistry, Purdue University, West Lafayette, IN
Genetics Research Forum, Michigan State University, East Lansing, MI
Department of Botany, University of British Columbia, Vancouver BC, Canada
Department of Biology, University of Victoria, Victoria BC, Canada
American Chemical Society National Meeting, Atlanta, GA
Max-Plank Institute for Chemical Ecology, Jena, Germany
Abteilung Allgemeine und Entwicklungsphysiologie, Albrecht-von-Haller-Institutefor Plant Sciences, University of Göttingen, Göttingen, Germany
Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany
17th International Symposium on Plant Lipids, Michigan State University, East
Lansing, MI
Department of Biochemistry, Rice University, Houston, TX
Penn State University, Dept. of Entomology, University Park, PA
Induced resistance against pathogens and insects, Doorn, The Netherlands
Kansas State University, Manhattan, KS
Noble Foundation, Ardmore, OK
University of North Texas, Denton, TX
NRI Arthropod Herbivore Biology & Management Programs Awardee Workshop.
Reno, NV
Boyce Thompson Institute, Cornell University, Ithaca, NY
Regulatory Oxylipins Conference, Lausanne, Switzerland

4

2010

2011

2012

2013
2014

2015

2016

2017

Loomis Lecture, Department of Genetics, Development and Cell Biology, Iowa State
University, Ames, IA
Donald Danforth Plant Science Center, St. Louis, MO
9th International Congress on Plant Molecular Biology, St. Louis, MO
Institute of Biological Chemistry, Washington State University, WA
Michigan State University, Cell and Molecular Biology Retreat, Laingsburg, MI
Entomological Society of America Annual Meeting, San Diego, CA
Penn State University, Dept. Plant Biology, University Park, PA
Ohio State University, Depts. Plant Pathology and Entomology, Columbus, OH(Student-invited speaker)
22nd International Conference on Arabidopsis Research, Madison, WI
American Phytopathology Society Annual Meeting, Honolulu, HI
University of Nebraska, Symposium on plant abiotic and biotic stress responses,
Lincoln, NE
Molecular Biology Institute, UCLA, Los Angeles, CA
Science University, Michigan State University, East Lansing, MI
Inaugural Symposium on Plant Biotechnology for Health and Sustainability,
Michigan State University, East Lansing, MI
DOE Physical Biosciences Research Meeting, Potomac, MD
Department of Genetics, University of Wisconsin-Madison, Madison, WI
Plant Biological Science, University of Minnesota, Minneapolis, MN
Gordon Research Conference on Plant-Herbivore Interactions, Ventura, CA
Mid-Atlantic Plant Molecular Biology Society, Laurel, MD
Interdepartmental Plant Biology Program, University of Iowa, Ames, IA
Cold Spring Harbor Frontiers and Techniques in Plant Biology Course, Cold Spring
Harbor, NY
American Society of Plant Biologists Annual Meeting, Portland, OR
DOE Physical Biosciences Research Meeting, Annapolis, MD
Dow Gardens and Master Gardner Association, Midland, MI
Institute of Biological Chemistry, Washington State University, Pullman, WA
Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Göttingen,Germany
Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany
International Symposium, ‘Bridging Ecology and Molecular Biology: Organismic
Responses to Recurring Stress”, Berlin, Germany
Cold Spring Harbor Frontiers and Techniques in Plant Biology Course, Cold Spring
Harbor, NY
PRL 50th Anniversary Symposium, Michigan State University, East Lansing, MI
Department of Biological Sciences, Western Michigan University, Kalamazoo, MI
Department of Entomology, Michigan State University, East Lansing, MI
Gordon Research Conference on Plant Volatiles, Ventura CA
Entomological Society of America annual meeting, Orlando, FL
University of Western Ontario, Ontario, CA
Phytochemical Society of North America (PSNA), Davis, CA
Department of Entomology, Texas A&M University, College Station, TX
Forum on Plant Resilience and Innovation, University of Tsukuba, Tsukuba, JapanRIKEN Center for Sustainable Resource Science, Yokohama, Japan
DOE-BES Photosynthesis Systems PI Meeting, Gaithersburg, MD

5

2018

2019

2020
2021
2022

University of Nevada at Reno, Reno, NV
Molecular Plant Science Program, Michigan State University, East Lansing, MI
4th Annual Symposium Plant Biochemistry, Leibniz Institute of Plant
Biochemistry, Halle (Saale), Germany
Guest speaker, Great Lakes Bioenergy Research Center’s “Field-to-FuelOptimization” meeting
Agricultural Bioscience International Conference 2018, Weifang, China
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences,
Beijing, China
ASPB Midwest Meeting, Morgantown, WV
Regulatory Oxylipins Meeting, Ghent, Belgium
Dept. of Biochemistry & Biophysics, Texas A&M University, College Station, TX
DOE-BES Photosynthesis Systems PI Meeting, Gaithersburg, MD
Dept. of Biology, Wilfrid Laurier University, Ontario, CA
Dept. of Botany, University of Wisconsin at Madison, WI
31st International Conference on Arabidopsis Research, Seattle, WA
Annual Meeting of the Entomological Society, Denver, CO
Plant Biotechnology for Health and Sustainability
Institute of Biological Chemistry, Washington State University, Pullman, WA

PUBLICATIONS
Citation details at:https://scholar.google.com/citations?user=76LRNMEAAAAJ&hl=en&oi=ao
1. Bruschi CV, Comer A, Howe G (1987) Specificity of DNA uptake during whole celltransformation of Saccharomyces cerevisiae. Yeast 3: 131-137.
2. Bruschi CV, Howe G (1988) High frequency FLP-independent DNA recombination of the
2 micron plasmid in the yeast Saccharomyces cerevisiae. Curr Genet 14: 191-199.
3. Howe G, Aldrich J (1988) Use of oligonucleotide probes to discriminate chloroplastencoded streptomycin-resistant from streptomycin-sensitive tobacco plants using total
DNA mini-preps. Plant Mol Biol Rep 64: 258-265.
4. Howe G, Kutsunai S, Merchant S (1990) Physiological factors affecting the accumulationof plastocyanin, cytochrome c-552, and a 30-kD soluble protein in Chlamydomonas
reinhardtii. In, Current Research in Photosynthesis, Vol. III (ed. M. Baltscheffsky),
Kluwer Academic Publishers, The Netherlands, pp 13.711-13.714.
5. Merchant S, Hill K, Howe G (1991) Dynamic interplay between two Cu-titrating
components in the transcriptional regulation of cytochrome c6. EMBO J 10: 1383-1389.
6. Howe G, Merchant S (1992) Heavy-metal induced peptides in Chlamydomonas
reinhardtii. Plant Physiol 98: 127-136.
7. Howe G, Quinn J, Hill K, Merchant S (1992) Control of the biosynthesis of cytochrome c6
in Chlamydomonas reinhardtii. Plant Physiol Biochem 30: 299-307.
8. Howe G, Merchant S (1992) The biosynthesis of membrane and soluble plastidic c-type
cytochromes of Chlamydomonas reinhardtii is dependent on multiple common geneproducts. EMBO J 11: 2789-2801.
9. Howe G, Merchant S (1993) The maturation of thylakoid lumen proteins proceeds posttranslationally through an intermediate in vivo. Proc Natl Acad Sci USA 90: 1862-1866.

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10. Howe G, Merchant S (1994) Role of heme in the biosynthesis of cytochrome c6. J Biol
Chem 269: 5824-5832.
11. Howe G, Merchant S (1994) The biosynthesis of bacterial and plastidic c-type
cytochromes. Photosynthesis Research 40:147-165.
12. Howe G, Mets L, Merchant S (1995) Biosynthesis of cytochrome f in Chlamydomonas
reinhardtii: analysis of the pathway in gabaculine-treated cells and in the heme
attachment mutant B6. Mol Gen Genet 246: 156-165.
13. Conconi A, Smerdon M, Howe G, Ryan C (1996) The octadecanoid signaling pathway
mediates a UV response in plants. Nature 383: 826-829.
14. Bergey D, Howe G, Ryan C (1996) Polypeptide signaling for plant defensive genes
exhibits analogies to defense signaling in animals. Proc Natl Acad Sci USA 93: 1205312058.
15. Howe G, Lightner J, Browse J, Ryan C (1996) An octadecanoid pathway mutant (JL5) of
tomato is compromised in signaling for defense against insect attack. Plant Cell 8: 20672077.
16. Howe G, Ryan C (1999) Suppressors of systemin signaling identify genes in the tomato
wound response pathway. Genetics 153: 1411-1421.
17. Howe GA, Lee GI, Itoh A, Li L, DeRocher A (2000) Cytochrome P450-dependent
metabolism of oxylipins in tomato: Cloning and expression of allene oxide synthase andfatty acid hydroperoxide lyase. Plant Physiol 123: 711-724.
18. Froehlich JE, Itoh A, Howe GA (2001) Tomato allene oxide synthase and fatty acidhydroperoxide lyase, two cytochrome P450s involved in oxylipin metabolism, aretargeted to different membranes of chloroplast envelope. Plant Physiol 125: 306-317.
19. Itoh A, Howe GA (2001) Molecular cloning of a divinyl ether synthase. Identification asa novel CYP74 cytochrome P450. J Biological Chemistry 276: 3620-3627.
20. Li L, Howe GA (2001) Alternative splicing of prosystemin pre-mRNA in tomato
generates two active forms of the prosystemin wound signal. Plant Mol Biol 46: 409-419.
21. Li L, Li C, Howe GA (2001) Genetic analysis of wound signaling in tomato: Evidence
for a dual role of jasmonic acid in defense and female fertility. Plant Physiol 127: 14141417.
22. Howe GA (2001) Cyclopentenone signals for plant defense: Remodeling the jasmonate
response. Proc Natl Acad Sci USA 98: 12317-12319.
23. Li L, Li C, Lee GI, Howe GA (2002) Distinct roles for jasmonic acid synthesis and actionin the systemic wound response of tomato. Proc Natl Acad Sci USA. 99: 6416-6421.
24. Li C, Williams M, Loh Y-t, Lee G-I, Howe GA (2002) Resistance of cultivated tomato tocell-content feeding herbivores is regulated by the octadecanoid signaling pathway. Plant
Physiol. 130:494-503.
25. Strassner J, Schaller F, Frick U, Howe GA, Weiler EW, Amrhein N, Macheroux P,
Schaller A. (2002) Characterization and cDNA microarray expression analysis of 12oxophytodienoate reductases reveals differential roles for octadecanoid biosynthesis in
local versus systemic wound responses. Plant J. 32: 585-601.
26. Itoh A, Schilmiller AL, McCaig B, Howe GA (2002) Identification of a jasmonateregulated allene oxide synthase that metabolizes 9-hydroperoxides of linoleic andlinolenic acids. J Biological Chemistry 277: 46051-46058.
27. Howe GA, Li L, Lee GI, Li C, Shaffer D (2002) Genetic dissection of induced resistancein tomato. In, Induced Resistance in Plants Against Insects and Diseases. A. Schmitt & B.
Mauch-Mani, Eds. vol. 26, pp. 47-52.

728. Howe G, Schilmiller (2002) Oxylipin metabolism in response to stress. Curr Op Plant
Biol. 5:230-236.
29. Lee GI, Howe GA (2003) The tomato mutant spr1 is defective in systemin perception
and the production of a systemic wound signal for defense gene expression. Plant J. 33:
567-576.
30. Li C, Liu G, Xu C, Lee GI, Bauer P, Ling HQ, Ganal MW, Howe GA (2003) The tomato
Supperssor of Prosystemin-mediated Responses2 (Spr2) gene encodes a fatty aciddesaturase required for the biosynthesis of jasmonic acid and the production of a systemic
wound signal for defense gene expression. Plant Cell 15: 1646-1661.
31. Zhao Y, Thilmony R, Bender C, Schaller A, He SY, Howe GA (2003) Virulence systemsof Pseudomonas syringae pv. tomato promote bacterial speck disease in tomato bytargeting the jasmonate signaling pathway. Plant J. 36: 485-499.
32. Li L, Zhao Y, McCaig BC, Wingerd BA, Wang J, Whalon ME, Pichersky E, Howe GA(2004) The tomato homolog of COI1 is required for maternal control of seed maturation,jasmonate-signaled defense responses, and glandular trichome development. Plant Cell.
16: 126-143.
33. Chen H, McCaig BC, Melotto M, He SY, Howe GA (2004) Regulation of plant arginaseby wounding, jasmonate, and the phytotoxin coronatine. J Biological Chemistry 279:
45998-46007.
34. Howe GA (2004) Jasmonates as signals in the wound response. J. Plant Growth Reg.
23:223-237.
35. Li C, Schilmiller AL, Liu G, Lee GI, Jayanty S, Sageman C, Vrebalov J, Giovannoni JJ,
Yagi K, Kobayashi Y, Howe GA (2005) Role of b-oxidation in jasmonate biosynthesis
and systemic wound signaling in tomato. Plant Cell 17: 971-986.
36. Chen H, Wilkerson CG, Kuchar JA, Phinney BS, Howe GA (2005) Jasmonate-inducible
plant enzymes degrade essential amino acids in the herbivore midgut. Proc. Natl. Acad.
Sci. USA 102: 19237-19242.
37. Howe G (2005) Jasmonates. In, Plant Hormones: Biosynthesis, Signal Transduction, andAction! (ed. Peter J. Davies), pp. 610-634, Kluwer Academic Publishers, The
Netherlands.
38. Schilmiller AL, Howe GA (2005) Systemic signaling in the wound response. Curr Opin
Plant Biol. 8:369-377.
39. Cañoles MA, Beaudry RM, Li C, Howe GA (2006) Deficiency of linolenic acid in fad7
mutant tomato changes the volatile profile and sensory perception of disrupted leaf andfruit tissue. J Amer Soc Hort Sci 131: 284-289.
40. Chen H, Jones AD, Howe GA (2006) Constitutive activation of the jasmonate signaling
pathway enhances the production of secondary metabolites in tomato. FEBS Letters 580:
2540-2546.
41. Powers RA, Rife CL, Schilmiller AL, Howe GA, Garavito RM (2006)
Structure determination and analysis of acyl-CoA oxidase (ACX1) from tomato. Acta
Crystallographica D 62: 683-686.
42. Ko J-H, Kim J H, Jayanty S, Howe GA, Han K-H (2006) Loss of function of COBRA, adeterminant of oriented cell expansion, invokes cellular defence responses in Arabidopsis
thaliana. J Exp Bot 57: 2923-2936.
43. Koo AJK, Chung HS, Kobayashi Y, Howe GA (2006) Identification of a peroxisomal
acyl-activating enzyme involved in the biosynthesis of jasmonic acid in Arabidopsis. J
Biol Chem. 281: 33511-33520.

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44. Oh K, Asami T, Matsui K, Howe GA, Murofushi N (2006) Characterization of novel
imidazole derivative, JM-8686, a potent inhibitor of allene oxide synthase. FEBS Letters,
580: 5791-5796.
45. Schilmiller AL, Koo AJK, Howe GA (2007). Functional diversification of acyl-CoAoxidases in jasmonic acid biosynthesis. Plant Physiol 143: 812-824
46. Chen H, Gonzales-Vigil E, Wilkerson CG, Howe GA (2007). Stability of plant defense
proteins in the gut of insect herbivores. Plant Physiol. 143: 1954-1967.
47. Thines B, Katsir L, Melotto M, Niu Y, Mandaokar A, Liu G, Nomura K, He SY, Howe
GA, Browse J (2007) JAZ repressor proteins are targets of the SCFCOI1 complex duringjasmonate signaling. Nature 448: 661-665.
48. Kandoth PK, Ranf S, Pancholi S, Jayanty S, Miller M, Howe GA, Lincoln D, andStratmann JW (2007) The tomato MAP kinases LeMPK1, LeMPK2, and LeMPK3
function in the systemin-mediated defense response against herbivorous insects. Proc.
Natl. Acad. Sci. USA. 104: 12205-12210.
49. Koo AJK, Howe GA (2007). Role of peroxisomal β-oxidation in the production of plantsignaling compounds. Plant Signaling and Behavior. 2: 20-22
50. Howe GA, Browse J (2007) Jasmonate synthesis and action in higher plants. In:
Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester http://www.els.net/[DOI: 10.1002/9780470015902.a0020138]
51. Chung HS, Koo AJK, Gao X, Jayanty S, Thines B, Jones AD, Howe GA (2008)
Regulation and function of Arabidopsis JASMONATE-ZIM domain genes in response towounding and herbivory. Plant Physiol. 146: 952-964.
52. Katsir L, Schilmiller AL, Staswick PE, He SY, Howe GA (2008). COI1 is a criticalcomponent of a receptor for jasmonate and the bacterial virulence factor coronatine. Proc
Natl Acad Sci USA. 105: 7100-7105.
53. Chen H, Gonzales-Vigil E, Howe GA (2008) Action of plant defensive enzymes in theinsect midgut. In, Induced Plant Resistance to Herbivory, A. Schaller, ed. Springer
Publishing Co.
54. Howe GA, Schaller A (2008) Direct defense induced by wounding and herbivores. In,
Induced Plant Resistance to Herbivory, A. Schaller, ed. Springer Publishing Co.
55. Jander G, Howe GA (2008) Plant interactions with arthropod herbivores: State of the
field. Plant Physiol. 146:1-3.
56. Browse J, Howe GA (2008) Update on jasmonate signaling: New weapons and a rapid
response against insect attack. Plant Physiol. 146: 832-383.
57. Howe GA, Jander G (2008) Plant immunity to insect herbivores. Annu. Rev. Plant Biol.
59: 41-66.
58. Katsir L, Chung HS, Koo AJK, Howe GA (2008) Jasmonate signaling: a conserved
mechanism of hormone sensing. Curr Opin Plant Biol. 11:428-435.
59. Farmer EE, Howe GA, Pearce G, Schaller A (2008) Obituary: Clarence A. "Bud" Ryan
(1931-2007). Phytochemistry 69:1454-1456.
60. Melotto M, Mecey C, Niu Y, Chung HS, Katsir L, Yao J, Zeng W, Staswick P, Browse J,
Howe GA, He SY (2008) A critical role of two positively charged amino acids in the Jas
motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucinedependent interaction with the COI1 F-box protein. Plant J. 55: 979-988.
61. Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR (2008) Investigation ofsubstrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases.
Lipids 14:979-987

962. Chung HS, Howe GA (2009) A critical role for the TIFY motif in repression ofjasmonate signaling by a stabilized splice variant of the JASMONATE ZIM-domain
protein JAZ10 in Arabidopsis. Plant Cell 21: 131-145.
63. Koo AJK, Gao X, Jones AD, Howe GA (2009) A rapid wound signal activates systemic
synthesis of bioactive jasmonates in Arabidopsis. Plant J. 59: 974-986.
64. Chung HS, Niu Y, Browse J, Howe GA (2009) Top hits in contemporary JAZ: An updateon jasmonate signaling. Phytochemistry 70:1547–1559.
65. Koo AJK, Howe GA (2009). The wound hormone jasmonate. Phytochemistry 70:15711580.
66. Kang JH, Shi F, Jones AD, Marks D, Howe GA (2010) Distortion of trichomemorphology by the hairless mutation of tomato affects leaf surface chemistry. J Exp Bot.
61: 1053-1064.
67. Chung HS, Cooke TF, DePew CL, Patel C, Ogawa N, Kobayashi Y, Howe GA (2010)
Alternative splicing expands the repertoire of dominant JAZ repressors of jasmonate
signaling. Plant J 4: 613-622.
68. Kang JH, Liu G, Shi F, Jones AD, Beaudry RM, Howe GA (2010) The tomato odorless-2
mutant is defective in trichome-based production of diverse specialized metabolites andbroad-spectrum resistance to insect herbivores. Plant Physiol. 154: 262-272.
69. Sheard LB, Tan X, Mao H, Withers J, Nissan GB, Hinds TR, Kobayashi Y, Hsu F-F,
Sharon M, Browse J, He SY, Rizo-Rey J, Howe GA, Zheng N (2010) Mechanism ofjasmonate recognition by an inositol phosphate-potentiated COI1-JAZ co-receptor.
Nature. 468: 400-405.
70. Howe GA (2010) Update: The jasmonate receptor. In, Plant Hormones: Biosynthesis,
Signal Transduction, and Action! (3rd edition, revised; ed. Peter J. Davies), Kluwer
Academic Publishers, The Netherlands.
71. Howe GA (2010) Ubiquitin ligase-coupled receptors extend their reach to jasmonate.
Plant Physiol. 154:471-474.
72. Gonzales-Vigil E, Bianchetti, CM, Phillips, GN, Howe GA (2011) Adaptive evolution of
threonine deaminase in plant defense against insect herbivores. Proc Natl Acad Sci USA.
108: 5897-902.
73. Koo AJK, Cooke TF, Howe GA (2011) Cytochrome P450 CYP94B3 mediates
catabolism and inactivation of the plant hormone jasmonoyl-L-isoleucine. Proc Natl
Acad Sci USA. 108:9298-9303
74. Shyu C, Figueroa P, DePew CL, Cooke TF, Sheard LB, Moreno J, Katsir L, Zheng N,
Browse J, Howe GA (2012) JAZ8 Lacks a Canonical Degron and has an EAR Motif thatMediates Transcriptional Repression of Jasmonate Responses in Arabidopsis. Plant Cell,
24: 536-250.
75. Avila CA, Arévalo-Soliz LM, Jia L, Navarre DA, Chen Z, Howe GA, Meng QW, Smith
JE, Goggin FL (2012) Loss of function of FATTY ACID DESATURASE7 in tomato
enhances basal aphid resistance in a salicylate-dependent manner. Plant Physiol 158:
2028-2041.
76. Withers J, Yao J, Mecey C, Howe GA, Melotto M, He SY (2012) Transcription factordependent nuclear localization of a transcriptional repressor in jasmonate hormone
signaling. Proc Natl Acad Sci USA. 109: 20148-20153.
77. Erb M, Meldau S, Howe GA (2012) Role of phytohormones in insect-specific plant
reactions. Trends in Plant Sci. 17:250-259.
78. Koo AJK, Howe GA (2012). Catabolism and deactivation of the lipid-derived hormone
jasmonoyl-L-isoleucine. Front Plant Sci. 3:19

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79. Sanjaya, Miller R, Durrett TP, Kosma DK, Lydic TA, Muthan B, Koo AJK, Bukhman
YV, Reid GE, Howe GA, Ohlrogge J, Benning C (2013) Altered lipid composition andenhanced nutritional value of Arabidopsis leaves following introduction of an algal
diacylglycerol acyltransferase 2. Plant Cell, 25: 677-693.
80. Pourcel L, Irani NG, Koo AJ, Bohorquez-Restrepo A, Howe GA, Grotewold E (2013). A
chemical complementation approach reveals genes and interactions of flavonoids withother pathways. Plant J. 74: 383-397.
81. Nakata M, Mitsuda N, Herde M, Koo AJK, Moreno JE, Suzuki K, Howe GA, OhmeTakagi M (2013) A bHLH-type transcription factor, JA-INDUCIBLE MYC2-LIKE1,
acts as repressor to negatively regulate jasmonate signaling in Arabidopsis thaliana. Plant
Cell, 25: 1641-1656.
82. Moreno JE, Shyu C, Campos ML, Patel LC, Chung HS, Yao J, He SY, Howe GA (2013)
Negative feedback control of jasmonate signaling by an alternative splice variant of
JAZ10. Plant Physiol. 162: 1006-1017.
83. Bhosale R, Jewell JB, Hollunder J, Koo AJ, Vuylsteke M, Michoel T, Hilson P, Goossens
A, Howe GA, Browse J, Maere S (2013) Predicting gene function from uncontrolled
expression variation among individual wild-type Arabidopsis plants. Plant Cell 25: 28652877.
84. Herde M, Koo AJK, Howe GA (2013) Elicitation of jasmonate-mediated defense
responses by mechanical wounding and insect herbivory. Meth Mol Biol. 1011: 51-61
85. Chuang WP, Herde M, Ray s, Castano-Duque L, Howe GA, Luthe DS (2014) Caterpillar
attack triggers accumulation of the toxic maize protein RIP2. New Phytol. 201: 928-939.
86. Kang JH, McRoberts J, Shi F, Moreno J, Jones, AD, Howe GA (2014) The flavonoid
biosynthetic enzyme chalcone isomerase modulates terpenoid production in glandular
trichomes of tomato. Plant Physiol. 164: 1161-1174.
87. Herde M, Howe GA (2014) Host plant-specific remodeling of midgut physiology in thegeneralist insect herbivore Trichoplusia ni. Insect Biochem Mol Biol, 50: 58-67.
88. Attaran E, Major IT, Cruz JA, Rosa BA, Koo AJK, Chen J, Kramer DM, He SY, HoweGA (2014) Temporal dynamics of growth and photosynthesis suppression by jasmonate
signaling. Plant Physiol. 165: 1302-1314.
89. Koo AJK, Thireault C, Zemelis S, Poudel AN, Zhang T, Kitaoka N, Brandizzi F,
Matsuura H, Howe GA (2014) Endoplasmic reticulum-associated inactivation of thehormone jasmonoyl-L-isoleucine by multiple members of the cytochrome P450 94 family
in Arabidopsis. J Biol Chem, 289: 29728-29738.
90. Campos ML, Kang JH, Howe GA (2014) Jasmonate-triggered plant immunity. J Chem
Ecol. 40:657-675.
91. Thireault C, Shyu C, Yoshida Y, St Aubin B, Campos ML, Howe GA (2015) Repressionof jasmonate signaling by a lineage-specific JAZ protein in Arabidopsis. Plant J 82: 669679.
92. Liu MJ, Seddon AE, Major IT, Floer M, Howe GA, Shiu SH (2015). Determinants ofnucleosome positioning and their influence on plant gene expression. Genome Res, 25:
1182-1195.
93. Zhang L, Yao J, Withers J, Yao J, Xin X-F, Banerjee R, Fariduddin Q, Nakamura Y,
Nomura K, Howe GA, Boland W, Yan H, He SY (2015) Host target modification as a
strategy to counter pathogen hijacking of the jasmonate hormone receptor. PNAS 112:
14354-14359.

1194. Howe GA, Herde M (2015) Interaction of plant defense compounds with the insect gut:
New insights from genomic and molecular analyses. Curr Opin Insect Science. 9:62-68.
95. Havko NE, Major IT, Jewell J, Attaran E, Browse J, Howe GA (2016) Control of carbon
assimilation and partitioning by jasmonate: An accounting of growth-defense tradeoffs.
Plants. 5:7.
96. Campos ML, Yoshida Y, Major IT, de Oliveira Ferreira D, Weraduwage SM, Froehlich
JE, Johnson BF, Kramer D, Jander G, Sharkey TD, Howe GA (2016) Rewiring ofjasmonate and phytochrome B signaling uncouples plant growth-defense tradeoffs.
Nature Comm, 7, 12570.
97. Kang JH, Campos ML, Zemelis S, Al-Haddad JM, Jones AD, Telewski FW, Brandizzi F,
Howe GA (2016) Molecular cloning of the tomato Hairless gene implicates actin
dynamics in trichome-mediated defense and mechanical properties of stem tissue. J Exp
Bot, 67:5313-5324.
98. Okubara PA, Kang JH, Howe GA (2016) Belowground signaling and defense in hostPythium interactions. In Belowground Defence Strategies in Plants, K. Kazan and C.
Vos, eds. Pp. 171-193.
99. Zhang F, Jiyuan K, Zhang L, Chen R, Sugimoto K, Howe GA, Xu E, Melcher K, He SY(2017) Structural insights into alternative splicing-mediated desensitization of jasmonate
signaling. Proc Natl Acad Sci USA, 114:1720-1725.
100. Major IT, Yoshida Y, Campos ML, Kapali G, Xin XF, Sugimoto K, Ferreira DO, He
SY, Howe GA (2017) Regulation of growth-defense balance by the JAZ-MYC
transcriptional module. New Phytol. 215: 1533-1547.
Highlighted in a Commentary by C. Wasternack (2017) “A plant’s balance of growthand defense – revisted”, New Phytol. 215: 1291-1294.
101. Jeong N-R, Kim H, Hwang I-T, Howe GA, Kang JH (2017) Genetic analysis of thetomato inquieta mutant links the ARP2/3 complex to trichome development. J Plant Biol,
60: 582-592.
102. Howe GA (2018) Metabolic end run to jasmonate. Nat Chem Biol 14: 109-110.
103. Weraduwage S.M., Campos M.L., Yoshida Y., Major I., Kim Y-S., Kim S-J., Renna L.,
Anozie F.C., Brandizzi F., Thomashow M.F., Howe G.A., Sharkey T.D. (2018)
Molecular Mechanisms Determining Leaf Architecture. In: Adams III W. W., Terashima
I. (eds), The Leaf: A Platform for Performing Photosynthesis. Advances in
Photosynthesis and Respiration (Including Bioenergy and Related Processes), vol 44.
Springer, Cham104. Howe GA, Major IT, Koo AJ (2018) Modularity in jasmonate signalling for multistressresilience. Annu Rev Plant Biol 69: 387-415.
105. Gou Q, Major IT, Howe GA (2018) Resolution of growth-defense conflict: Mechanistic
insights from jasmonate signaling. Curr Opin Plant Biol 44:72-81.
106. Wang K, Guo Q, Froehlich J, Hersh H, Zienkiewicz A, Howe GA, and Benning C(2018) Two abscisic acid responsive plastid lipase genes involved in jasmonic acidbiosynthesis in Arabidopsis thaliana. Plant Cell 30: 1006-1022.
106. Liu MJ, Sugimoto K, Uygun S, Panchy N, Campbell MS, Yandell M, Howe GA, Shiu
SH (2018) Regulatory divergence in wound-responsive gene expression between
domesticated and wild tomato. Plant Cell, 30: 1445-1460.
107. Toyota M, Spencer D, Sawai-Toyota S, Jiaqi W, Zhang T, Koo AJ, Howe GA, Gilroy S(2018). Glutamate triggers long-distance, calcium-based plant defence signaling.
Science, 361: 1112-1115.

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108. Guo Q, Yoshida Y, Major IT, Wang K, Sugimoto K, Kapali G, Havko NE, Benning C,
Howe GA (2018) JAZ repressors of metabolic defense promote growth and reproductive
fitness in Arabidopsis. PNAS 115: E10768-E10777.
109. Howe GA, Yoshida Y (2019) Evolutionary origin of JAZ proteins and jasmonate
signaling. Molecular Plant, 12:153-155.
110. Howe GA (2019) Auspicious beginnings for the plant defense hormone jasmonate. Plant
Cell, 31:1198-1199.
111. Havko NE, Das MR, Kapali G, McClain A, Sharkey TD, Howe GA (2020) Insect
herbivory antagonizes leaf cooling responses to elevated temperature in tomato. PNAS,
17:2211-2217.
112. Havko NE, Howe GA (2020) Crops could face double trouble from insects and awarming climate. The Conversation. Apr. 7, 2020.
113. Major IT, Guo Q, Zhai J, Kapali G, Savage L, Kramer DM, Howe GA (2020). A
phytochrome B-independent pathway restricts growth at high levels of jasmonate
defense. Plant Physiol, 183:733-749.
114. Havko NE, Kapali G, Das MR, Howe GA (2020) Stimulation of insect herbivory by
elevated temperature outweighs protection by the jasmonate pathway. Plants,
DOI: 10.3390/plants9020172
115. Pan J, Wang H, Guo Q, Chen Y, Hu Y, Howe GA, Yu D. (2020) Molecular mechanism
underlying the synergetic effect of jasmonate on abscisic acid signaling during seedgermination in Arabidopsis. Plant Cell, 32:3846-3865.
116. Sugimoto K, Zager JJ, St. Aubin B, Lange BM, Howe GA (2021) Flavonoid deficiency
disrupts redox homeostasis and terpenoid biosynthesis in glandular trichomes of tomato.
Plant Physiol, 188:1450-1463.
117. Guo Q, Major IT, Kapali G, Howe GA (2022) MYC transcription factors coordinate
tryptophan-dependent defense responses and compromise seed yield in Arabidopsis.
New Phytologist, 236:132-145.

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