高齢者ブレインバンク https://www2.tmig.or.jp/brainbk/
リソース研究_研究成果_2020 年度【和文総説】
1.

村山繁雄，齊藤祐子：【神経変性疾患の治療開発の現状-新たな戦略構築の基盤をめざして】治療開発のバックアップシステム ブレインバンク．医学のあゆみ. 273 (1): 100-104, 2020.04

2.

村山繁雄，齊藤祐子：【パーキンソン病研究の最前線】家族性パーキンソン病の病理．医学と薬学.
(7): 1017-1022, 2020.06

3.

村山繁雄，齊藤祐子：【パーキンソン病-New concept?】総論 病態生理 病気はどこから 鼻粘膜とパーキンソン病．Clinical Neuroscience. 38 (7): 830-831, 2020.07

4.

島かさ音, 種井善一, 高原実香, 村上永尚, 山本伸昭, 坂東良美, 松原知康, 村山繁雄, 和泉唯信：腎移植から27年後に発症した延髄原発リンパ増殖性疾患の一例．臨床神経学. 60 (5): 386, 2020.05. 会議録

5.

小林 敬, 仙石錬平, 仁科裕史, 金丸和富, 村山繁雄, 秋本高義：起立性低血圧で発症し、広汎な自律神経障害を呈した49歳男性例．臨床神経学. 60 (5): 374.2020.05. 会議録

6.

齊藤祐子：カラーグラビア 病理アトラス慢性炎症と神経疾患．慢性炎症と疾患症．別冊BIO Clinoca. 9(2): 1-4, 2020.12

7.

村山繁雄，齊藤祐子 :（編集）貫名信行. 神経変性疾患の治療開発の現状―新たな戦略構築の基盤をめざして【ブレインバンク】．別冊・医学のあゆみ. 100-104, 2021. 02

77

神経疾患と慢性炎【著書等】
1.

齊藤祐子：カラーグラビア 病理アトラス慢性炎症と神経疾患．慢性炎症と疾患症．別冊BIO Clinoca. 9(2): 1-4, 2020.12

神経疾患と慢性炎【誌上発表】（含 2020 年度電子ジャーナル発表）
1．Hamaguchi T, Sakai K, Kobayashi A, Kitamoto T, Ae R, Nakamura Y, Sanjo N, Arai K, Koide M, Katada F,Harada M, Murai H, Murayama S, Tsukamoto T, Mizusawa H, Yamada M: Characterization of Sporadic Creutzfeldt-Jakob Disease and History of Neurosurgery to Identify Potential Iatrogenic Cases. Emerging infectious diseases 2020, 26:1140-6.
2．Hata S, Hu A, Piao Y, Nakaya T, Taru H, Morishima-Kawashima M, Murayama S, Nishimura M, Suzuki T:
Enhanced amyloid-beta generation by gamma-secretase complex in DRM microdomains with reduced cholesterollevels. Hum Mol Genet 2020, 29:382-93.
3. Hideshima M, Beck G, Yamadera M, Motoyama Y, Ikenaka K, Kakuda K, Tsuda H, Nagano S, Fujimura H,Morii E, Murayama S, Mochizuki H: A clinicopathological study of ALS with L126S mutation in the SOD1 genepresenting with isolated inferior olivary hypertrophy. Neuropathology 2020, 40:191-5.
4. Imai M, Tanaka M, Sakata M, Wagatsuma K, Tago T, Toyohara J, Sengoku R, Nishina Y, Kanemaru K, Ishibashi K, Murayama S, Ishii K: Metabolic Network Topology of Alzheimer's Disease and Dementia with Lewy Bodies
Generated Using Fluorodeoxyglucose Positron Emission Tomography. J Alzheimers Dis 2020, 73:197-207.
5. Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N,

Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S,Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, IkedaM, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K,Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, ImotoI, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y,Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H,Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M,Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, YamamotoK, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M,Kamatani Y: Large-scale genome-wide association study in a Japanese population identifies novel
susceptibility loci across different diseases. Nat Genet 2020, 52:669-79.
6. Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S,Ihara Y: gamma-Secretase Activity Is Associated with Braak Senile Plaque Stages. Am J Pathol 2020,
190:1323-31.
7. Koshi-Mano K, Mano T, Morishima M, Murayama S, Tamaoka A, Tsuji S, Toda T, Iwata A: Neuronspecific analysis of histone modifications with post-mortem brains. Scientific reports 2020, 10:3767.
8. Moriguchi S, Takahata K, Shimada H, Kubota M, Kitamura S, Kimura Y, Tagai K, Tarumi R, Tabuchi
H, Meyer JH, Mimura M, Kawamura K, Zhang MR, Murayama S, Suhara T, Higuchi M: Excess tau
PET ligand retention in elderly patients with major depressive disorder. Mol Psychiatry 2020,25(7):18.
9. Omura T, Motoyama R, Tamura Y, Nonaka K, Tanei ZI, Shigemoto K, Tokumaru AM, Murayama S,Arai T, Araki A: Meningoencephalitis caused by masked mastoiditis that was diagnosed during afollow-up in an elderly patient with diabetes mellitus: A case report. Geriatr Gerontol Int 2020, 20:5001.
10. Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T,
Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SHW, Goedert M: Structures ofalpha-synuclein filaments from multiple system atrophy. Nature 2020, 58:464-469.
11. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa
K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T,Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H: YAP-dependentnecrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. NatCommun 2020, 11(1):507.
12. Uchino A, Nagai M, Kanazawa N, Ichinoe M, Yanagisawa N, Adachi K, Nanba E, Ishiura H, MitsuiJ, Tsuji S, Suzuki K, Murayama S, Nishiyama K: An autopsy case of GM1 gangliosidosis type II in apatient who survived a long duration with artificial respiratory support. Neuropathology 2020
Aug;40(4):379-388.
13. Yoshinaga S, Yamanaka T, Miyazaki H, Okuzumi A, Hiyama A, Murayama S, Nukina N: Preserved
proteinase K-resistant core after amplification of alpha-synuclein aggregates: Implication to diseaserelated structural study. Biochem Biophys Res Commun 2020, 522:655-61.
14. Zhang W, Tarutani A, Newell KL, Murzin AG, Matsubara T, Falcon B, Vidal R, Garringer HJ, Shi
Y, Ikeuchi T, Murayama S, Ghetti B, Hasegawa M, Goedert M, Scheres SHW: Novel tau filament foldin corticobasal degeneration. Nature 2020, 580:283-7.

15. Tanei ZI, Saito Y, Ito S, Matsubara T, Motoda A, Yamazaki M, Sakashita Y, Kawakami I, Ikemura
M, Tanaka S, Sengoku R, Arai T, Murayama S. Lewy pathology of the esophagus correlates with theprogression of Lewy body disease: a Japanese cohort study of autopsy cases. Acta Neuropathol. 2021
Jan;141(1):25-37.
16. Arakawa A, Saito Y, Seki T, Mitsutake A, Sato T, Katsumata J, Maekawa R, Hideyama T, Tamura
K, Hasegawa M, Shiio Y: Corticobasal degeneration with deep white matter lesion diagnosed by brainbiopsy. Neuropathology. 2020, 40(3):287-294.
17. Sugiyama A, Sato N, Kimura Y, Fujii H, Shigemoto Y, Suzuki F, Tanei ZI, Saito Y, Sasaki M,Takahashi Y, Matsuda H, Kuwabara S: The cerebellar white matter lesions in dentatorubralpallidoluysian atrophy. J Neurol Sci. 2020, 15:416.
18. Minakawa EN, Popiel HA, Tada M, Takahashi T, Yamane H, Saitoh Y, Takahashi Y, Ozawa D,Takeda A, Takeuchi T, Okamoto Y, Yamamoto K, Suzuki M, Fujita H, Ito C, Yagihara H, Saito Y, Watase
K, Adachi H, Katsuno M, Mochizuki H, Shiraki K, Sobue G, Toda T, Wada K, Onodera O, Nagai Y:Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation.
Brain. 2020 143(6):1811-25
19. Kawazoe T, Uruha A, Mori-Yoshimura M, Saito Y, Ikeda SI, Saji M, Tanimura A, Amano T,Okamoto T, Oya Y, Murata M, Nishino I, Takahashi Y: A 67-Year-Old Man with Leg Weakness andHypertrophic Cardiomyopathy. Brain Pathol. 2020, 30(2):427-428
20. Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C, Takado Y, Shinotoh H, Sano Y,Yamamoto Y, Matsuoka K, Takuwa H, Shimojo M, Takahashi M, Kawamura K, Kikuchi T, Okada M,Akiyama H, Suzuki H, Onaya M, Takeda T, Arai K, Arai N, Araki N, Saito Y, Trojanowski JQ, Lee VMY,Mishra SK, Yamaguchi Y, Kimura Y, Ichise M, Tomita Y, Zhang MR, Suhara T, Shigeta M, Sahara N,Higuchi M, Shimada H: High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and NonAlzheimer's Disease Tauopathies. Neuron. 2021,109(1) 42-58.
21. Satoh JI, Kino Y, Yanaizu M, Ishida T, Saito Y: Reactive astrocytes express Aggregatin (FAM222A)in the brains of Alzheimer's disease and Nasu-Hakola disease. Intractable Rare Dis Res. 2020
Nov;9(4):217-221.
22. Fukumoto Y, Miyama T, Tanei ZI, Saito Y, Ota Y: Reactive bite-related tongue lesions in cognitively
impaired epilepsy patients: A report of two cases. Spec Care Dentist. 2020,40(3):285-290.
23. Nagano S, Jinno J, Abdelhamid RF, Jin Y, Shibata M, Watanabe S, Hirokawa S, Nishizawa M,Sakimura K, Onodera O, Okada H, Okada T, Saito Y, Takahashi-Fujigasaki J, Murayama S, WakatsukiS, Mochizuki H, Araki T: TDP-43 transports ribosomal protein mRNA to regulate axonal local
translation in neuronal axons. Acta Neuropathol. 2020,140(5):695-713.
24. Tasuku Ishihara, Tomoko Okamoto, Ken Saida, Yuji Saitoh, Shinji Oda, Terunori Sano, TakuhiroYoshida, Yuki Morita, Atsushi Fujita, Hiromi Fukuda, Noriko Miyake, Takeshi Mizuguchi, Yuko Saito,Yoshiki Sekijima, Naomichi Matsumoto, Yuji Takahashi. Neuronal intranuclear inclusion disease
presenting with an MELAS-like episode in chronic polyneuropathy. Neurol Genet Dec 2020, 6 (6) e531.
25. Matsubara T, Izumi Y, Oda M, Takahashi M, Maruyama H, Miyamoto R, Watanabe C, Tachiyama
Y, Morino H, Kawakami H, Saito Y, Murayama S: An autopsy report of a familial amyotrophic lateralsclerosis case carrying VCP Arg487His mutation with a unique TDP43 proteinopathy. Neuropathology.
2020, 41(2): 118-126.

27. Tarutani A, Miyata H, Nonaka T, Hasegawa K, Yoshida M, Saito Y, Murayama S, Robinson AC,Mann DMA, Tomita T, Hasegawa M. Human tauopathy-derived tau strains determine the substrates
recruited for templated amplification. Brain. 2021,144:2333-2348.
28. Ben J. E. Raveney, Sato W, Takewaki D, Chenyang Z, Kanazawa T, Youwei L, Okamoto T, Araki
M, Kimura Y, Sato N, Sano T, Saito Y, Oki S, Yamamura T: Involvement of cytotoxic Eomes-expressing
CD4+ T cells in secondary progressive multiple sclerosis. PNAS 2021,March 16; 118 (11): e2021818118
29. Kametani F, Yoshida M, Matsubara T, Murayama S, Saito Y, Kawakami I, Onaya M, Tanaka H,Kakita A, Robinson AC, Mann DMA, Hasegawa M. Comparison of Common and Disease-Specific Posttranslational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies. FrontNeurosci. 2020 Nov 4;14:581936.