高齢者ブレインバンク https://www2.tmig.or.jp/brainbk/
リソース研究_研究成果_2019 年
1. Fujita K, Matsubara T, Miyamoto R, Sumikura H, Takeuchi T, Maruyama, Saladini K,Kawarai T, Nodera H, Udaka F, Kume K, Morino H, Kawakami H, Hasegawa M, Kaji R,Murayama S, Izumi Y: Co-morbidity of progressive supranuclear palsy and amyotrophic
lateral sclerosis: a clinical-pathological case report. BMC Neurol 2019, 19:168.
2. Hatsuta H, Takao M, Nogami A, Uchino A, Sumikura H, Takata T, Morimoto S,Kanemaru K, Adachi A, Arai T, Hasegawa M, Murayama S: Tau and TDP-43
accumulation of the basal nucleus of Meynert in individuals with cerebral lobar infarcts
or hemorrhage. Acta Neuropathologica Communications. 2019; 7(1): 49.
3. Hongo Y, Iizuka T, Kaneko A, Suga H, Uchino A, Murayama S, Namba K, Inoue Y,Nishiyama K: An autopsy case of MM2-thalamic subtype of sporadic Creutzfeldt-Jakob
disease with Lewy bodies presenting as a sleep disorder mimicking anti-IgLON5 disease.
J Neurol Sci 2019, 404:36-9.
4. Ikegawa M, Nirasawa T, Kakuda N, Miyasaka T, Kuzuhara Y, Murayama S, Ihara Y:
Visualization of Amyloid beta Deposits in the Human Brain with Matrix-assisted Laser
Desorption/Ionization Imaging Mass Spectrometry. J Vis Exp 2019.
5. Ishiura H, Shibata S, Yoshimura J, Suzuki Y, Qu W, Doi K, Almansour MA, Kikuchi JK,Taira M, Mitsui J, Takahashi Y, Ichikawa Y, Mano T, Iwata A, Harigaya Y, Matsukawa
MK, Matsukawa T, Tanaka M, Shirota Y, Ohtomo R, Kowa H, Date H, Mitsue A, Hatsuta
H, Morimoto S, Murayama S, Shiio Y, Saito Y, Mitsutake A, Kawai M, Sasaki T,Sugiyama Y, Hamada M, Ohtomo G, Terao Y, Nakazato Y, Takeda A, Sakiyama Y,Umeda-Kameyama Y, Shinmi J, Ogata K, Kohno Y, Lim SY, Tan AH, Shimizu J, Goto J,Nishino I, Toda T, Morishita S, Tsuji S: Noncoding CGG repeat expansions in neuronal
intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping
disease. Nat Genet 2019, 51:1222-32.
6. Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M,Murayama S, Ihara Y, Miyasaka T: Distribution of endogenous normal tau in the mousebrain. J Comp Neurol 2019, 527:985-98.
7. Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A,Takashima A, Kato T, Onodera O, Goto M, Ito M, Tomiyama T, Mori H, Murayama S,Ihara Y, Misonou H, Miyasaka T: Ectopic Expression Induces Abnormal Somatodendritic
Distribution of Tau in the Mouse Brain. J Neurosci 2019, 39:6781-97.
8. Kurihara M, Koda H, Aono H, Izumi S, Sakurai Y, Sano T, Saito Y, Murayama S, Mori M:
Rapidly progressive miliary brain metastasis of lung cancer after EGFR tyrosine kinase
inhibitor discontinuation: An autopsy report. Neuropathology. 2019; 39: 147-155
9.

Matsubara T, Oda M, Takahashi T, Watanabe C, Tachiyama Y, Morino H, Kawakami H, KajiR, Maruyama H, Murayama S, Izumi Y: Amyotrophic lateral sclerosis of long clinical course
clinically presenting with progressive muscular atrophy. Neuropathology. 2019; 39: 47-53．

10. Matsuda Y, Itabashi M, Tachibana Y, Sugihara T, Sakashita Y, Matsubara T, Murayama
S, Yumura W, Shimizu A, Takei T, Arai T: Citrullinated histone H3 expression inanti-neutrophil cytoplasmic antibody-associated vasculitis in older Japanese autopsypatients. Geriatr Gerontol Int 2019.

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11. Matsuda Y, Nonaka K, Seki A, Kakizaki M, Takakuma S, Hamamatsu A, Wang T,Nakano Y, Takata T, Takahashi-Fujigasaki J, Murayama S, Sawabe M, Arai T:
Disseminated varicella zoster virus infection and acute hepatitis: Autopsy-proven cases
from a single institute. Pathol Int 2019, 69:378-80.
12. Nelson P, Dickson D, Trojanowski J, Jack Jr. C, Boyle P, Arfanakis K, Rademakers R,Alafuzoff I, Attems J, Brayne C, Chui H, Coyle-Gilchrist I, Fardo D, Flanagan M,Halliday G, Hokkanen S, Hunter S, Jicha G, Katsumata Y, Kawas C, Keene C, Kovacs G,Kukull W, Levey A, Makkinejad N, Montine T, Murayama S, Murray M, Nag S, Rissman
R, Seeley W, Sperling R, White C, Yu L, Schneider J: Limbic-predominant Age-related
TDP-43 Encephalopathy (LATE): Consensus Working Group Report. Brain. 2019; 142:1503-1527
13. Nonaka K, Matsuda Y, Kakizaki M, Takakuma S, Hamamatsu A, Sakashita Y,Matsubara T, Murayama S, Ishiwata T, Yamanaka N, Itabashi M, Takei T, Nakajima N,Hasegawa H, Arai T: Acute liver failure associated with influenza A virus infection: anautopsy case report. Jpn J Infect Dis 2019.
14. Nonaka K, Matsuda Y, Kakizaki M, Takakuma S, Matsubara T, Murayama S, Ishiwata T,Kameyama M, Ogura K, Kobayashi S, Arai T: Occult mucin-producing urothelial-typeadenocarcinoma of the prostate with elevated serum levels of carcinoembryonic antigen
and carbohydrate antigen 19-9: Report of an autopsy-proven case. Urol Case Rep 2019,23:6-9.
15. Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B,
Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC: Humanization of theentire murine Mapt gene provides a murine model of pathological human tau propagation.
J Biol Chem 2019, 294:12754-65.
16. Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki
S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI: Tau
isoform expression and phosphorylation in marmoset brains. J Biol Chem 2019,294:11433-44.
17. Tachibana M, Mohri I, Hirata I, Kuwada A, Kimura-Ohba S, Kagitani-Shimono K,Fushimi H, Inoue T, Shiomi M, Kakuta Y, Takeuchi M, Murayama S, Nakayama M,
Ozono K, Taniike M: Clasmatodendrosis is associated with dendritic spines and does not
represent autophagic astrocyte death in influenza-associated encephalopathy. Brain &development 2019, 41:85-95.
18. Tago T, Toyohara J, Harada R, Furumoto S, Okamura N, Kudo Y, Takahashi-Fujigasaki J,Murayama S, Ishii K: Characterization of the binding of tau imaging ligands tomelanin-containing cells: putative off-target-binding site. Annals of nuclear medicine
2019, 33:375-82.
19. Tago T, Toyohara J, Sengoku R, Murayama S, Ishii K: MAO-B binding of 18F-THK5351
visualized glioblastoma and associated gliosis: an autopsy- confirmed case. Clin Nucl Med.
2019; 44: 507-509
20. Takahashi Y, Uchino A, Shioya A, Sano T, Matsumoto C, Numata-Uematsu Y, Nagano S,Araki T, Murayama S, Saito Y: Altered immunoreactivity of ErbB4, a causative geneproduct for ALS19, in the spinal cord of patients with sporadic ALS. Neuropathology 2019,39:268-78.

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21. Yu WY, Xu Z, Lee HY, Tokumaru A, Tan JMM, Ng A, Murayama S, Lim CCT: Identifying
patients with neuronal intranuclear inclusion disease in Singapore using characteristic
diffusion-weighted MR images. Neuroradiology. 2019;61,1281-1290.
22. Kawakami I, Arai T, Hasegawa M: The basis of clinicopathological heterogeneity in TDP-43
proteinopathy, Acta Neuropathol. 2019;138(5):751-770.
23. Kurihara M, Mano T, Saito Y, Murayama S, Toda T, Iwata A: Colocalization of BRCA1

with tau aggregates in human tauopathies. Brain Sciences, 10(1) 2019 Dec 20. Doi:10.
3390/brainsci 10010007.
24. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, IwataA, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A,Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue
G, Murayama S, Okazawa H: YAP-dependent necrosis occurring in early stages regulates
Alzheimer’s-like pathology in mice. Nature Comm. 2020 Jan 24;11(1):507. doi:
10.1038/s41467-020-14353-6.

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