Appendix ：Grouping Organ Names

Target organs

Grouped organ names when multiple organs areapplicable（1st level）

Grouped organ names when multiple organs areapplicable（2nd level）

Grouped organ names when multiple organs areapplicable（3rd level）

Grouped organ names when multiple organs areapplicable（4th level）

Remarks■Organ names -single exposureRespiratory tract irritation

Respiratory tract irritation

Narcotic effects

Narcotic effects

Respiratory system
Respiratory organs

Respiratory system

Respiratory tract

Respiratory tract

If coexisting with organs for respiratory system, set
as "respiratory system"■Organ names -single exposure/repeated exposure -Upper respiratory tract
Upper respiratory organs
Nasal cavity
Nasal cavity (olfactory epithelia)
Nasal mucous membrane
Olfactory organs
Nasopharynx
Lower respiratory tract
LarynxTrachea
Bronchial tubes
Lungs
Nervous system
NervesCentral nerves
Central nervous system
Central neurological
Brain
Cranial nervous system
Spinal cord
Optice nerve
Peripheral nerves
Peripheral nervous system
Autonomic nerves
Autonomic nervous system
Motor nerves
Motor nervous system

The respiratory system is a general term for theupper respiratory tract and the lower respiratorytract.

Upper respiratory tract
Upper respiratory tract

Nasal cavity

Respiratory system
Respiratory tract

Nasopharynx
Lower respiratory tract
LarynxTrachea
Bronchial tubes
Lungs

Lower respiratory tract

Nervous system
Central nerves
Central nerves
Brain
Spinal cord
Optice nerve

Nervous system

Peripheral nerves

The peripheral nerves is a general term for theautonomic nerves and the motor nerves.
Peripheral nerves

Autonomic nerves
Motor nerves

Optic organs
Eyes
RetinaVisual system

Optic organs

Auditory organs
Sense of hearing
Sensory organ (sense of hearing)

Auditory organsBlood system
Blood
Red blood cells
Blood coagulation system
Hematopoietic organs
Hematopoietic system
Bone marrow

Blood system
Blood
Red blood cells
Blood coagulation system
Hematopoietic organs
Hematopoietic system
Bone marrow

Immune system

Blood system
Hematopoietic organs

Immune system

Reticuloendothelial system

Reticuloendothelial system

ThymusSpleenLymph system
Lymph nodes

ThymusSpleenLymph system
Lymph nodes

The reticuloendothelial system is cells that attach
to the sinusoids of inside of the macrophages,
spleen, lymph nodes, and bone marrow.

Immune system

Circulatory systemCirculatory organs
Cardiovascular system
HeartHeart muscle
Vascular system
Blood vessels
Cerebral blood vessels
Digestive system
Digestive organs
Digestive tract
Oral cavity
Esophagus
StomachIntestinal tract
Small intestine
Duodenum
Large intestine
Salivary gland
Submandibular gland
Pancreas
Teeth
Gums
Periodontal tissue
Liver
Gallbladder
Urinary organs
Urinary system
KidneyBladder
Reproductive system
Reproductive organs
Accessory reproductive organs
Male reproductive organs
Reproductive organs (man)TestesAppendix testis
Prostate
Female reproductive organs
Reproductive organs (woman)
OvaryUterus

Lymph system

Circulatory system
Circulatory system

Heart
Blood vessels
Cerebral blood vessels

Excluding liver and gallbladder. (Theliver/gallbladder is separated from the digestivesystem).

Digestive system
Digestive tract
Oral cavity
Esophagus
StomachDigestive tract
Digestive tract

Intestinal tract
Small intestine

Digestive system

Intestinal tract

The digestive tract is a general term for the oralcavity, esophagus, stomach, and intestinal tract.
The Intestinal tract is a general term for the small
intestine and large intestine.

Large intestine
Salivary gland
Pancreas
Teeth
Periodontal tissue

Teeth/periodontium

Liver
Gallbladder

Liver/gallbladder

Urinary system
Urinary system

KidneyBladder
Reproductive system
Accessory reproductive organs
Male reproductive organs
TestesAppendix testis
Prostate

Male reproductive organs

Reproductive system

Female reproductive organs
OvaryUterus

Female reproductive organs

Endocrine system
Pituitary gland
Thyroid gland
Parathyroid
Parathyroid gland
Adrenal gland

Endocrine system
Pituitary gland
Thyroid gland

Skin
Skin appendages
Skin (appendages)
Sweat gland
Sebaceous gland
Nail
Hair root
Hair
Hair (hair loss)
Body hair

Skin

Muscular system
MuscleSkeletal muscle

Muscular system
MuscleSkeletal muscle

Skeletal system
BoneSkeleton
Bone tissueJoints

Skeletal system
Bone

Skeletal system

Systemic toxicity
Systemic symptoms
Systemic

Systemic toxicity
Systemic symptoms
Systemic

Systemic toxicity

Endocrine system

Parathyroid
Adrenal gland

Skin appendages
Skin/skin appendages

HairMuscular system

Date of revision：April 1, 2021