高齢者ブレインバンク https://www2.tmig.or.jp/brainbk/
リソース研究_研究成果_2018 年
1. Hata Y, Ma N, Yoneda M, Morimoto S, Okano H, Murayama S, Kawanishi S, Kuzuhara S,Kokubo Y: Nitrative Stress and Tau Accumulation in Amyotrophic Lateral
Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) in the Kii Peninsula, Japan.
Front Neurosci. 2018. 11:751. doi: 10.3389/fnins.2017.00751.
2.

Matsuda Y, Seki A, Nonaka K, Kakizaki M, Wang T, Aida J, Ishikawa N, Nakano Y, Kaneda D, TakataT, Takahashi-Fujigasaki J, Murayama S, Takubo K, Ishiwata T, Sawabe M, Arai T: Clinicopathologicalcharacteristics of distant metastases of adenocarcinoma, squamous cell carcinoma and urothelial
carcinoma: An autopsy study of older Japanese patients. Geriatr Gerontol Int, 2018;18(2):211-215.

3. Uchino A, Ogino M, Takahashi-Fujigasaki J, Oonuma S, Kanazawa N, Kajita S. Ichinoe M, Hasegawa
M, Nishiyama K, Murayama S: Pathological and immunoblot analysis of phosphorylated TDP-43 insporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration. Neuropathology, 2018
Apr;38(2):171-178. doi: 10.1111/neup.12430.
4. Morimoto S, Hatsuta H, Motoyama R, Kokubo Y, Ishiura H, Tsuji S, Kuzuhara S, Murayama S:
Optineurin pathology in the spinal cord of amyotrophic lateral sclerosis/parkinsonism-dementia
complex patients in Kii Peninsula, Japan. Brain Pathol, 2018; 28(3): 422-426.
5. Morimoto S, Takao M, Nishina Y, Sakurai K, Komiya T, Kanemaru K, Murayama S: Spinocerebellar
ataxia type 2 presenting with rapidly progressing muscle weakness and muscular atrophy. Geriatr
Gerontol Int, 2018;18(2):361-364.
6. Nagata K, Mano T, Murayama S, Saido TC, Iwata A: DNA methylation level of the neprilysin
promoter in Alzheimer's disease brains. Neurosci Lett, 2018;670:8-13.
7. Zhao Y, Perera G, Takahashi-Fujigasaki J, Mash DC, Paul J, Vonsattel G, Uchino A, Hasegawa K,Nichols RJ, Holton JL, Murayama S, Dzamko N, Halliday GM : Reduced LRRK2 in association withretromer dysfunction in postmortem brain tissue from LRRK2 mutation carriers. Brain, 2018; 141(2):486-495.
8. Endo R, Takashima N, Nekooki-Machida Y, Komi Y, Hui KK, Takao M, Akatsu H, Murayama S,Sawa A, Tanaka M: TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation
Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration.
Biol Psychiatry, 2018;84(7):509-521
9. Hasegawa I, Takeda A, Hatsuta H, Kubo Y, Ohsawa M, Nakano Y, Ikeuchi T, Hasegawa M, Murayama
S, Itoh Y: An autopsy case of globular glial tauopathy presenting with clinical features of motor
neuron disease with dementia and iron deposition in the motor cortex. Neuropathology, 2018.
38:372-379
10. Lionnet A, Leclair-Visonneau L, Neunlist M, Murayama S, Takao M, Adler CH, Derkinderen P, Beach
TG: Does Parkinson's disease start in the gut?. Acta Neuropathol, 2018;135(1):1-12.
11. Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, Yoneda M, Hirokawa Y, Kuzuhara S,
Shiraishi T, Murayama S: Unusual tau pathology of the cerebellum in patients with amyotrophic1

lateral sclerosis/parkinsonism-dementia complex from the kii peninsula, Japan. Brain Pathol
2018 ;28(2):287-291.
12. Nishioka M, Bundo M, Ueda J, Katsuoka F, Sato Y, Kuroki Y, Ishii T, Ukai W, Murayama S,Hashimoto E, Nagasaki M, Yasuda J, Kasai K, Kato T, Iwamoto K: Identification of somatic
mutations in postmortem human brains by whole genome sequencing and their implications forpsychiatric disorders. Psychiatry Clin Neurosci 2018;72(4):280-294.
13. Omoto S, Hayashi T, Matsuno H, Higa H, Kameya S, Sengoku R, Takahashi-Fujigasaki J, MurayamaS, Iguchi Y: Neuronal intranuclear hyaline inclusion disease presenting with childhood-onset night
blindness associated with progressive retinal dystrophy. J Neurol Sci, 2018;388: 84-86.
14. Sano K, Atarashi R, Satoh K, Ishibashi D, Nakagaki T, Iwasaki Y, Yoshida M, Murayama S, Mishima

K, Nishida N : Prion-Like Seeding of Misfolded alpha-Synuclein in the Brains of Dementia withLewy Body Patients in RT-QUIC. Mol Neurobiol. 2018 ;55(5):3916-3930

15. Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi KS, Murayama S. Hwang H,
Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K: Soluble epoxide hydrolase plays a keyrole in the pathogenesis of Parkinson's disease. Proc Natl Acad Sci U S A. 2018;115(25):E5815-E5823
16. Tarutani A, Arai T, Murayama S, Hisanaga SI, Hasegawa M: Potent prion-like behaviors ofpathogenic alpha-synuclein and evaluation of inactivation methods. Acta Neuropathol Commun,
2018;6(1): 29.
17. Higashihara M, SonooM, Ishiyama A, Nagashima Y, Matsumoto K, Uesugi H, Mori Yoshimura M, Murata
M, Murayama S, Komaki H: Quantitative Analysis of Surface Electromyography for Pediatric
Neuromuscular Disorders. Muscle Nerve, 2018;58:824–827

18. Izumi Y, Miyamoto R, Fujita K, Yamamoto Y, Yamada H, Matsubara T, Unai Y,Tsukamoto A, Takamatsu N, Nodera H, Hayashi S, Oda M, Mori A, Nishida Y, Watanabe
S, Ogawa H, Uehara H, Murayama S, Sata M, Kaji R: Distinct Incidence of Takotsubo
Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A CohortStudy.Front Neurol. 2018;9:1099

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