Vol.3 No.3 2008

粘膜免疫の基礎−全身性免疫と粘膜性免疫−
The mucosal immune system

第３巻３号
２００８

林智 人

Tomohito Hayashi

The mucosal immune system6174>@B3-5<%;89B3+>@9B3%s-ëEp¸ð`ë O«¶ @\ñ«¤Ø%+/,1!,312 Þ¬J=SÃ&/0h-!1&
ÉøfQrzb$Lb²B!F^`FPBK#.(/,$Ôo!)f*M78MûÚZ;[QWñY®½¦<"GPçJD]MCfPro~\çJPZ]õX}dl~/ÌONPZ]

kmlD]"ÉøfLR'öZ%MBKQ

oîQ\µ®P#Bµ®D8µ"<]TAwd|ta$gX´.£Qvæ`.èMBGU

^]?MPZ]\QÙQ7!7_Y])ù

D8Of>PZ]bÙ<.èL6\!éîf*`4BKôeA^]?M<!;IG"

CfLR¹=DÏZ%MBK?=5½aX4B;B??-,íLP:>]fQ¢ýOê:½aM¯S^]z~s£<µ®D8Of

PZ\!6[Y]\µ®P#D]f>`>`kBD]ÍiPO]"?^[Qz~s£R!

RAE]ycqixR*×LRO=!m#O

6]Y]Wñ\Q¶ïï]`­]>]?MQÖ½a!úä6]7R]Â<lBG[ÀOfho]½a@MPOIG{jvk$]Â`½anxQÝPï\pIK7]?M<e[;PA^XgPÆIK7]"{jvk$Rµ®`­]>

KoG"]b~npQi`BK:\!5½aQßºR§L!DPfQ«¤L/hA^K7]?M

5½a{jvk$%TCR&!4½aQßºRµR!MQò;L6]¯¡!Û6]7"MACfe|uz~%Ig&<FQi`+Rñã!TK!TIONQ7_Y]Md

8"ÉøfLjD]wd|ta$gXÑâ©úäLRFQúäPDBKR)BG)Md½aON<væBGWñ\QZ`z~s£Pîf*Qÿ¿<e[;PA^G?ML6]µ®6ÈD]M!?^[Q{jvk$`4BK'-("MdúäLR!¯¡Xæ\.Qn\z~s£Pµ®Qá_<<_\!f>³

Q¡ÒQ¾ON!àP\`"GPÎ\»U

`¥=RAE]GVz~s£<]uüãD]"Nî<6]GV!f©QD1L6]É°MU¼Ó8PWñ\QÐtXõrPº_EG¼9É°QÊ^MFQªOfQâ$!DO_H½a`3òÜD]

?]f>R!ùé

îfMö`BGB=T`V9K7]"N`RD])½aîf*6]7Rµ"`.

c·LR!¼§e[;PA^GMdîf!

èMBKµ®`QÙD]N`RD])îf*`÷(B!"G;[Wñ\`QÙD]DP2fPJ7KôD]")0!1*"?^[Qf>R!SPõ
#;89B3!2?=,:A'0*&)B3"$ZP¼W§7Øþz~sóL?\%ì.&!

ùéîQfR!)Éøf*M)Cf*ñ±RCVKòåD]Wñ\µ®PÖ8M!

QHÕb²LõP5µD]?M<,[^K7FQµ®PD8Oµ"`ÁñD]4½a%¨]%ì-&'.!/("S8OûÚZ;[QË½a&PO]<!=Dµ"`ÁñBG4Wñ\çJP:>]f>QÇ8Oq^R!

½aRX<KFQi`Ó9]MÄPÅ]"?

― 105 ―

Journal of the Japanese Society for Clinical Infectious Disease
in Farm Animals Vol.3 No.3 2008

粘膜免疫の基礎4MBGo-GvÚYoÿpqßCK$µrú0Í7!à8ð»ô0ÞÎäF±(%"7/7oóG)úHð»ôCG¿+F

æY7A1>FH!¦w|ÀRTzÓFÆ+Hu;:!Ç¡CGÏ¿®øY.7A.2^d#aBr)ú0õ,É¯7*R2ÐÿprúCETØ~ÎäBÍ9U4C+G IgG ÎY»7Að»ôYê©9U4BÞà8G±æFï-U"C0¤(U"4VYåÿpqßCK$µ(%"4GÂ²¸GÿpéY³mÜF)%7A!|
À0#Å5VUð»ôG¹õ$i\_j%FÏ9UoÿpqßY*S/8P"á5;A.1!+6<Gð»ôGÁ|À04@>
FÙ?Fåÿpqß0"á¤(UR,FºÕGÎ.RJÿprúY¥ï7A.2G0&i\_b#]fj'GüÜE-ùB*U"7/744BÖl7E3VIESE+4CH!ºÕGñð»ôFÏ9UãnÎtYPA.24CGN0i\_b#]fjCX
V0?B*U0!ÎG»ÎäBGÍÌ~0ÿprúG<VFîLA'/FÒ+C+,4CY-UC!O7WÿprúY¢õ+{÷9UC+,4C0i\_b#]fjG
F.+APA£&B*T!i\_b#]fj
Y¹5;UeZj`CEU"
7/7E0SèýBGÿpìqF7AH!
4G$EÂ²¸G IgG ÎG»¨CHüÜFnE@A+U4CYö7A-A.2
4C0Ð¼B*U""=?@7,/#Äªók/S±æ9Uñð»ôQÖFRUi\_j0!§Ëgjc¾!/Ê*U+H¶Bÿpqß9UGFÏ7!«s}QâEDGèýÃ°/SG±æBH<Gókã!Gÿpìq0SVU4C044·çBþS/F
E@>"4VYÂ²¸ÿpFÏ7&èý¸ÿp'CK"èýHyxCG½ÝCEU­§B*T!
<V=V!FëÑ7>ÿpÃ°FRTyx/"&8>)<($;9:.5023!146%SGñð»ôG±æYû+B+U"×}FH-*'+#

òËgjc¾HcZ[híCIVUgjcÃ

FÎäFÛG®øYÔT´27A+Uÿp
日本家畜臨床感染症研究会誌
３巻３号 2008°0Ý7!4VSYÈ¬7A×}òËgjc

― 106 ―

The mucosal immune systemtissue #4J¥¢!õN0­;9D>KEý&Eýß

GALT'L£S&Ò-'!üGOþ&>OQÏ'?`!?]OD`9{r!¡bJ&bronchus associated lymphoid tissue#ñÊ-OBALT'L£R`_3ä{rØ93_"=J IgA ±Ö¸­;O8@!¬ÀõO¥Ø & gut associated lymphoid

R`!t|r%2­;PÅ=b½¢!õ IgA ¥çbñ$O8,A_&¹¤ßÏ'"IgA ¥ç8,PËLN_&>P¹¤ßÏLEýßÏQ!&>@ÃáP&common mucosal immune system#CMIS'K
R`J7^!>P,»PyqnoKÝÑÓ@LN_êP&>Ó@b¦ÔA_&Ò.'"rdg|*QïÊ-­;&follicle!associated epithelium#FAE'L£R`_Ê-­;O6a`!DPîO1­;L£R`_¥¢P¼
安部原図（文献４）^ªXbÚDLA_SBb´EN4­;9å®
A_&Ò-'(-!/)"1­;b@J¼^ªW`E0Ö7¥¢Q!FAE PòKéF¦6!)(*'%$#&"ñ&>Ê-1AOQ!&Ó3_4QMûÓJ4_vh}sc%jZ¾Ê­;NMP¥¢ôNMOI;7KõN<ÇÆPæ!{lm%µ­;O\^TÐ?`!D`b@E¥¢Ì:x!zhosf{NMPõ¥7¸O\92­;3_4Q0­;Oö6]`G$N@

_4a[_¥¢.!õN<ÇÆ9/aGJù9Eý?`_>LON_"rdg|*P

7^&&>Ó@O7=_¶Ü@'!?]O

4OQ?]O{rR;L£R`_O93^!

¥¢!õOñ$O8,?`_ IgA ¥çDPËO74J IgA ¥çb±ÖA_0­;99Û<ÇOFA_&&>Ó@O7=_

8âÎA_"DP{rR;P¿9OQ CD

ÿ@'"¡ÕîP IgA ¥çQ IgG ¥çPNO,IÓ2­;&!O CD-IÓ­;'9ÁWGJ

+VQ_8OÉN4NK3_9!çîOQë7^!­;Ó@OFA_ Th*­;!3_NOW`J4_">P IgA ¥çQò×P°4QÓ@OFA_ Th+­;L@JP¯Hb´EB!0Ö79´H×í8²&>`'bÿ@!8âÎA_">PËO7=_ Th

9¥¢LNGJ4_'O!õO©A_>L+­;90­;Oè@ú:8=!¥¢!õ IgA

O\^2¢0Ö7PÊ-­;U3í7\Sóí¥çPëN±ÖbãA>LON_"WE!Th*bà³A_"WE IgA ¥çQ2¢0Ö79±­;Y>PËK8âÎ@!rdg|*8]ñ

ÖA_"ÞZ¨ÞO

©A_>LO\^!DP

>{rØbJñ8]¡ÃO%^!

¤b·aC_îQ¯H&?"'Y´GJ7«÷ñO&>ßÏPR;OC^&>`bu%^!"Þ9¢LN_LNMb<<ú:93wiL£T'Û­;b(?C!¬ÀõO_"ç$8]­Zed|kP)Çb§N5"

ñO74J>P IgA ¥çP±ÖP@&>KQ!>P\5N@¦b#¶O´H

ùbì54Q!ÙO@E GALT K3_"

>L8]!=õOQðºKP~hm¥¢Pñ$O¼^ªW`E¥¢Oè@JQ!rdg

øF&ÝÑÓ@'KQ!&>ÄKú;¥¢|*O3_p%xÍP{rÈØP5©çO7!õN IgA ¥çP±ÖbãA>LQÂJN

― 107 ―

Journal of the Japanese Society for Clinical Infectious Disease
in Farm Animals Vol.3 No.3 2008

粘膜免疫の基礎

9AM>òY=OB\K9["DN]IÄ¼À!('*)"

ó}^OCK³åÂèÃPî±^ôÖ/$Áõê­$0..5$$áðó}=YP

MCHu`evQÌ¯üN9AM^xñCKÃ M ó } ~ Û  ¡$ª  {  È  039["GPôÖPyOQáðó}°^CH(0.)&/!1$u`ej'crv>æúMN[*5+"0$#Ò½$0..5$ó}O<@[ºÐMÎÜè$²TPØC!ó}cdgoMÅù$àïÓ$²Ãµ¨0(/)&/!5$
1$# Ò½!0..5!ó}îe'oPpvk'¶Mmt'cdgo!àïÓ$²Ãµ2$wç¨!0(1)&/!4$!!0..5!áðó}%Õó}O´×MÚKK!àïÓ$²Ãµ ¨!
1(0)&4/!43$
3$#

Ò½$0..6$,ó}-cdgo^Ï:Ç¸%£í%é§MGPâÖö$Ó»ÿ 33(3)&07/!1..$!#&%$"

4$Îõã¦$0..5$áðó}=YPÃMó

³=YPÃî±^ôÖMCH·¢!Ô«u`evLQÞzÖN IgAÊP¥Â^ÉDAMQ¯üN9>!GPOáðáð^D[AMOXZÄ¼Àó}(IgGXSáðÀó}(IgA}~Û¡$ª{È 03(0.)&//6!/04$
5$õÑÒì#Áõ$0..5$áðó}PÊ)<ÅòMG\^~ùCHáðu`evPÊ)PþëPó}~Û

ä$àïÓ$²Ãµ ¨1(0)&^÷ÝD[AM>¯ü[AM>òY=OB\K45!5/$9["%;R!atsßÆ8blqifh^ä

6$Nochi#T$#Yuki#Y$#Matsumura#A$#

BFHap¬§^n_dO¹UBF[M!aMejima#M$#Terahara#K$#Kim#D$Y$#

tsßÆ8blqifhOËD[Ä¼Àó}Fukuyama#S$# Iwatsuki!Horimoto#(K$#Kawaoka#Y$#Kohda#T$#Kozaki#ÞzÖ IgGðÀó}(Ê)P÷ÝPVNYEáÞzÖ IgAÊ)>÷Ý¯ü!

S$#Igarashi#O$and Kiyono#H$0..5$

BYOª¤APn_dOatsÃ^BFKW

A novel M cell!specific carbohydrateÖOÃû¿>¯ü[AMWòY=OB\!targeted mucosal vaccine effectively*6!7+!Ùø¯ü[©¾ÍPu`einduces antigen!specific immune re-vMCKÔôB\K9["sponses$J$Exp$Med$0.2(/0)& 0567®{Ó¥"|O<9KW!Ùø>âL=JýX?u`ev

ÞzÖ IgA!0574$

Ê>

7$Noch#i T$#Takagi#H$#Yuki# Y$#¥Â¯ü[áðu`evPªù>B\[AM

Yang#L$#Masumura#T$#Mejima#^ÌCH9"M#$Nakanishi#U$#Matsumura#A$#
Uozumi#A$#Hiroi#T$#Morita#S$#

日本家畜臨床感染症研究会誌
３巻３号 2008― 108 ―

The mucosal immune system

Tanaka! K"! Takaiwa! F" and Ki-!chain! and needle!free vaccination"

yono!H"(&&-" Rice!based mucosal

Proc"Natl"Acad"Sci"'&*$(,%# '&/.,vaccine as a global strategy for cold!'&//'"The mucosal immune system

Tomohito Hayashi
National Institute of Animal Health$)!'!+ Kannondai!Tsukuba!Ibaraki!)&+!&.+, Japan%― 109 ―

Journal of the Japanese Society for Clinical Infectious Disease
in Farm Animals Vol.3 No.3 2008