Aaron Donoghue: Implementation of a multicenter registry for pediatric ED resuscitations using video recording • Jonathan Elmer:
Development of multimodal monitoring and treatment protocols for high-risk post-arrest patients • Timothy Chan: Optimizing public access
defibrillation deployment incorporating hours of operation • Joseph Stephen Piktel: Test hypothesis that therapeutic hypothermia will be
anti-arrhythmic during resuscitation and improve ROSC after VF arrest • Elizabeth Foglia: Use eye-tracking technology to characterize how
providers focus their visual attention during newborn resuscitation and assess the impact of a novel resuscitation monitor • Soren Rahbek:
To investigate temporal differences between asphyxial induced cardiac arrest (ACA) and ventricular fibrillation induced cardiac arrest(VFCA) and its impact on myocardial and neurological injury; to examine the temporal changes in brain and cardiac ATP levels, antioxidant
reserve, and the generation of reactive oxygen species • Keith Marrill: Potassium cardioplegia with calcium reversal for ventricularfibrillation arrest: a blinded randomized controlled trial • Lauge Vammen: Investigation of organ dysfunction of diabetics following cardiac
arrest • Steve Lin: The study of adrenaline and its effects on cardiac arrest • Cindy Hsu: Impact of mask application on aerosol generation
during CPR in a swine cardiac arrest model • Jonathan Paul: Study involving cardiogenic shock patients randomized to therapeutic
hypothermia plus standard medical care or standard medical care alone • Mathias Holmberg: Test use of Coenzyme Q10 for neuroprotectionin post-cardiac arrest patients to mitigate mitochondrial injury • Alexander Lindqwister: Role of electrical impedance in pseudo pulselesselectric activity • Katie DeJong: Determining the impact of telemedicine on outcomes after pediatric out-of-hospital cardiac arrest• Jonathan Rud: Level ofsoluble CD73 association
with outcome, andpredictive utility for postcardiac arrest cerebral
edema • Allison Cohen:
Time for a change: use of
Doppler ultrasound forchecking pulses in cardiac
arrest • Lenny Weiss:
December
2021
ReportTesting the impact of intrashift naps during night
shifts on blood pressure
dipping and heart ratevariability among EMS
clinicians • Christina Skare:Supporting young investigators worldwide
Effect of MAP on cerebral
perfusionand metabolism
with more than $3.3 million in resuscitation
after CA in porcine •Edilberto Amorin: Burstand critical care research grants
suppression with Propofol
for seizure control postcardiac arrest • Felipe
Teran-Merino: The usage
and effects of epinephrine in pseudo-PEA • Stephanie Frisch: Using machine learning algorithms to predict critical care outcomes fromemergency department triage data • Brian Weil: Determine whether systemic allogeneic CDC administration reduces myocardialand neurological injury in swine with post-cardiac arrest syndrome • Michael Glas: Aim to improve initial and long-term survival
and diminish neurological damage after global ischemia and reperfusion by administration of Hemarina-M101 after CA • Takamitsu
Ikeda: Effects of sedation on post-cardiac arrest neurological recovery • Heyi Li: Multidisciplinary implementation of inspiratory muscle
training for mechanically ventilated patients: a feasibility study • Marion Leary: Advance healthcare provider resuscitation quality using an
immersive augmented reality CPR training system • Aurora Magliocca: Impact of kynurenin pathway (KP) inhibition on survival andneurological outcome after cardiac arrest and CPR • Salvatore Aiello: Testing hypothesis that shock burden will intensify myocardial
injury • Junhwan Kim: Will test the prognostic potential of LPC using an established rate model of cardiac arrest and human patients• Madhan Shanmugasundaram: Test hypothesis that rapidly induced therapeutic hypothermia in those with acute coronary occlusion
extends the door to perfusion time from 120-240 minutes with no increase in myocardial infarct size • Stéphanie Pons: Endothelial
dysfunction and repair during septic shock: transcriptome analysis of circulating endothelial cells and blood outgrowth endothelial cells
by RNA-seq • Takeyuki Kiguchi: Establish the effectiveness of physiologically guided resuscitation by use of NIRS during CPR • Michael
Silverman: Determine potential neuroprotective effects of dexmedetomidine • Alexandra Weissman: Test the feasibility and yield of
nanopore sequencing, as compared to culture, for assessment of body fluid speciments from post cardiac arrest patients • Guillaume
Hoareau: Hypothesize that CPR augmented by balloon aortic occlusion benefits from adaptive balloon-wealing protocol tailored tomaintain a blood pressure • Wendy Van Ittersum: Rapid cycle deliberate practice in first five minutes training to improve team dynamics
and resuscitation skills • Mohd Fazrul Mokhtar: Augmented reality-cardiopulmonary resuscitation (AR-CPR) interactive handbook:
A feasibility study of augmented reality basic life support training for Malaysia public users • Kei Hayashida: Targeting heme oxygenase-1
with H2 gas inhalation to improve cardiac arrest outcomes • Hyo Joon Kim: Mechanisms of coagulation following OHCA and how
influenced by post arrest care including therapeutic hypothermia • Emily Bartlett: Feasiblity of random allocation to active RIC vs. Sham
RIC quickly upon ED arrival following resuscitation • Salvatore Aiello: Amplitude spectral area to assess hemodynamic and metabolic
interventions during cardiac arrest • Patrick Coppler: Compare personalized selection of an optimal MAP to each patient versus standard
hemodynamic management with all having same BP goal • Pedja Kovacevic: Intensive care knowledge translation in practice (ICU
knowledge-TIP) • Jennifer Bradley: Investigate the effects of WIN55, 212-2 on CB2 receptors following cardiopulmonary resuscitation• Michael Wagner: Improving simulation-based medical education in pediatric resuscitation: Real-time feedback and visual attention

ZOLL FOUNDATION

President’s Message
Dear Colleagues:
We are pleased to issue our fourth report on the activities of the ZOLL
Foundation. It covers the types of research and the support provided
to our target group of young researchers in resuscitation and criticalcare; all grants approved as of this writing; the process and timelines
for application; and our current financial status. It also recognizes
the help we have had in establishing what we now believe will be an
enduring organization supporting research in these important areas.
Our Board of Directors serves without compensation; we are especially indebted to Dr. Norman
Paradis who guided and shaped our work since agreeing to help us as we started our effort.
His dedication has been essential to our work and progress. He has brought his keen andrenowned knowledge, science, and experience to our work tirelessly. As applications havegrown, the work to review them and score them has grown as well. For our last two roundsof applications we have also had the benefit of Dr. Fumito Ichinose’s expertise. As our newest
elected Board Director, we thank him for his support and help.
As we look back on our original vision of being a place for younger researchers to apply for initialfunds, maybe for their first effort, for studies that could lead to further research and funding fromtheir efforts, we are always pleased to receive reports from our grant recipients of our initial
grants facilitating this objective.
I mention just two grants as examples and fully expect these portend more of the same. Dr. Praveen
Chandrasekharan’s research data from his grant, “A Novel Approach to Bradycardia during Preterm
Neonatal Resuscitation Using an Ovine Model of Asphyxia,” at the University of Buffalo, recently
secured R01 funding from NIH NICHD for further work in this effort to improve resuscitation.
Another grant we approved for Dr. Christoph Nabzdyk, at the Mayo Clinic in Rochester, Minnesota,
supported preclinical studies of a hemostatic paste that was inspired by the adhesion mechanismof barnacles. This work was published in Nature Biomedical Engineering and attracted widespreadrecognition from the World Economic Forum, given its broad clinical implications. Additional
funding from MIT, National Institutes of Health, the National Science Foundation, and the U.S. Army
Research Office is helping the team to work toward commercialization of the paste.
With the constraints of COVID affecting everything that could be done in person, the Board also
wanted to acknowledge in our report the retirement of Wanchun Tang, MD, a dedicated leader
in efforts to improve care, who has brought so much to the field of Critical Care and Resuscitation.
Please note our salute to him on the back cover.
We all hope this report will be useful in attracting applications, by explaining the relatively simple
digital process and the components of an application and required information for review, andultimately encourage more competition in the submissions for the grants we will make in the future.
We thank you for your interest and support.

Ward M. Hamilton
President
ZOLL Foundation

THE ZOLL FOUNDATION
Ward Hamilton, President
Retired ZOLL Employee
Richard Packer, Clerk
Chairman of ZOLL Medical Corporation,
and Primary Executive Officer ofAsahi Kasei HealthCare
John Bergeron, Treasurer
Retired ZOLL Employee
Fumito Ichinose, MD, PhD, Director
Director, William T.G. Morton Professor of
Anaesthesia, Harvard Medical School,
and Anesthetist at Massachusetts
General HospitalCoreen Packer, Director
Trustee of the Packer Family Trust
Norman Paradis, MD, Director
Professor of Medicine at DartmouthCollege and an emergency physician at
Dartmouth Hitchcock Medical Center
Jonathan Rennert, Director
CEO, ZOLL Medical Corporation
All Directors serve voluntarily and receive
no compensation.

Susan Schumacher, Administrator
Retired ZOLL Employee
Alyssa Fitzgerald, Esq., Counsel
Goodwin Proctor LLP, Boston, MA

ZOLL Foundation
269 Mill Rd.
Chelmsford, MA 01824
foundation@zollfoundation.org
www.zollfoundation.org

Grants
GRANT TITLE

RECIPIENTCOUNTRY

LEAD INVESTIGATOR

Changes in adult out-of-hospital cardiac arrest outcomes and contributing factors during the
COVID-19 pandemic in Texas

Univ. of Texas Health Science
Center at Houston

USA

Summer Chavez, DO, MPH,
MPM

Nebulized nitroglycerin to improve blood flow during cardiac arrest

Univ. of Utah

USA

Christopher Kelly, MD

Optimizing chest compression location: Is the lower sternum really ideal?

Feinstein Institutes for
Medical Research

USA

Daniel Rolston, MD,
MDHPM

Reduction of prothrombotic antibodies in COVID-19 patients who received convalescent plasma
in the clinical trial of COVID-19 convalescent plasma in outpatients (C3PO)

Univ. of Pittsburgh
School of Medicine

USA

Nadine Talia, MD

Impact of mask application on aerosol generation during CPR in a swine cardiac arrest model

Univ. of Michigan

USA

Cindy Hsu, MD, PhD

The therapeutic potential of combinational Lysophosphatidylcholine (LPC)
therapy in the treatment of severe injury rodent cardiac arrest

Feinstein Institutes for
Medical Research

USA

Muhammad Shoaib, MD,
PhD Candidate

Role of hemolysis and nitric oxide consumption after cardiac arrest

Mass. General Hospital

USA

Yusuke Miyazaki, MD, PhD

Safety and feasibility of Kefir administration in critically ill adults receiving antibiotics

Mayo Clinic

USA

Simon Zec, MD

Use of the cold shock protein fibroblast growth factor 21 to enhance hypothermic
neuroprotection in a rat model of pediatric asphyxial cardiac arrest

Univ. of Pittsburgh Schoolof Medicine

USA

Jeremy Herrmann, MD

Detecting intrathoracic airway closure during prehospital cardiopulmonary resuscitation

University Hospital Ghent

Belgium

Maxim Vanwulpen, MD

Immunomodulatory therapy for treating brain injury after cardiac arrest

Brigham and Women’s Hospital

USA

Tamura Tomoyoshi, MD, PhD

Lipidomics for prognostication after cardiac arrest (LOGIC) study

National Univ. Heart Centre

SingaporeShir Lynn Lim, MD

Novel insights into the prediction and etiology of in-hospital cardiac arrest

Aarhus Univ. Hospital

Denmark

Peter Carøe Lind, MD

Ex vivo use of a cell-permeable Succinate Prodrug will rescue ischemia and reperfusion injury to
mitochondria and cardiac function in donation after circulatory death (DCD) hearts

Virginia Commonwealth Univ.

USA

Jennifer Bradley, PhD

Effect of resuscitation quality improvement (RQI) program on CPR quality in out-of-hospital
cardiac arrest

Feinstein Institutes for Medical
Research, Northwell HealthUSA

Priam Chakraborty, DO

Influence of sedation on neurocognitive outcomes and quality of life following extracorporeal
membrane oxygenation for cardiac arrest and post-cardiotomy shock

Stanford Univ. School of Medicine

USA

Melissa Vogelsong, MD

Investigation of myocardial sympathetic denervation as a novel mechanism of ischemia-induced
pulseless electrical activity cardiac arrest

State Univ. of New Yorkat Buffalo

USA

Brian Weil, PhD

An informatics-driven approach to a multicenter neonatal resuscitation network

Children’s Hospital ofPhiladelphia

USA

Leah Carr, MD

Translationally relevant swine model of Lipopolysaccharide-induced septic shock to assessa perfusion-centered approach for the management of septic shock

Rosalind Franklin Univ. of
Medicine & Science

USA

Shahid Azib, MD

2021: $875,696

Since it was established through it latest grants, the ZOLL Foundation has now
awarded over $3.3 million dollars in to 88 recipients in 16 countries.

A Special Contribution Makes the Future Brighter
In March 2021, Asahi Kasei Corporation, a diversified Japanesemultinational, confirmed that its U.S. subsidiary ZOLL Medical
Corporation, a manufacturer of medical devices and related software
solutions, donated $10M (USD) to the non-profit ZOLL Foundation in
December 2020 to support research and educational activities forresuscitation and acute critical care. This donation will pave the way
for the award of additional grants well into the future.

Grants (cont’d)
GRANT TITLE

RECIPIENTCOUNTRY

LEAD INVESTIGATOR

Burst suppression with Propofol for seizure control post-CA

Univ. of California

USA

Edilberto Amorin, MD

Assessing synaptic density in CA survivors using [11C] UCB-J PET: a pilot study

Yale New Haven Hospital

USA

Rachel Beekman, MD

A novel approach to bradycardia during pre-term neonatal resuscitation using an ovine
model of asphyxia

Univ. at Buffalo

USA

Praveen Chandrasekaran,MD, MSTime for a change: use of Doppler ultrasound for checking pulses in CA

Feinstein Institutes for
Medical Research

USA

Allison Cohen, MD

Using unstructured clinical data to predict critical illness

Univ. of Pittsburgh

USA

Adam Frisch, MD

CPR-REBOA: improving outcome of prehospital cardiopulmonary resuscitation with balloon
occlusion of the descending aorta

Univ. Hospital Bern

Switzerland

Anja Levis, MD

Derivation and validation of a clinical decision rule for the early prediction of shock-refractory
VT/VF out-of-hospital CA

Oregon Health and Science Univ.

USA

Joshua Lupton, MD

Mitochondrial injury differs with age in rat model

Soochow Univ.

China

Yan Xiao, MD

Bioadhesive paste for instant hemorrhage control of vascular and solid organ injuries

Mayo Clinic

USA

Christoph Nabzdyk, MD

Dodecafluoropentane to reduce ischemic-reperfusion injury in a swine model of CA

Univ. of Florida

USA

Travis Murphy, MD

Evaluating neuroprotective therapies that modulate leukocyte Infiltration into the brain following
CA and resuscitation

Univ. of Pittsburgh

USA

Tanner Smida, NREMT-B

Humanizing the (ICU): perspectives of patients & their families on the use of the “Get to Know Me” board

Mayo Clinic

USA

Sumera Ahmad, MBBS

Mitochondrial dynamics as target for inhaled argon therapy after CA

Istituto di Ricerche
Farmacoogiche Mario Negri

Italy

Francesca Fumagalli, PhD

Increased mitochondrial-mediated survival with improved neurological recovery after Metformin
treatment for brain Injury after cardiac arrest

Feinstein Institutes for
Medicine, Northwell Health

USA

Rishabh Choudhary, PhD

Methylene blue for treatment of CA

Aarhus Univ. Hospital

Denmark

Lauge Vammen, MD

Using machine learning algorithms to predict critical care outcomes from ER triage data

Univ. of Pittsburgh

USA

Stephanie Frisch, PhD

Effects of sedation on post-CA neurological recovery

Mass. General Hospital

USA

Takamitsu Ikeda, MD

Multidisciplinary implementation of inspiratory muscle training for mechanically ventilated
patients: A feasibility study

Mayo Clinic

USA

Heyi Li, MD

CAMeLOT study: CA prediction by machine learning to improve outcome in tots

Univ. of Texas SW Medical Center

USA

Priscilla Yu, MD

Impaired organ repair after sepsis: role of tissue resident macrophages and recruited
monocytes (ORISMO)INSERM U976
Université de Paris

FranceCharles de Roquetaillade,MD

Augmented reality-cardiopulmonary resuscitation (AR-CPR) interactive andbook: A feasibility studyof augmented reality basic life support training for Malaysia public users

Universiti Teknologi MARA

Malaysia

Mohd Fazrul Mokhtar, MD

Aloud real-time reading of ICU diaries for prevention of negative post-ICU psychological outcomes:
A feasibility study

Mayo Clinic

USA

Kimberly Johnson, MD

Delivery room peak performance for neonates with congenital anomalies

Children’s Hospital of Philadelphia

USA

Heidi Herrick, MD

Investigate the effects of WIN55, 212-2 on CB2 receptors following cardiopulmonary resuscitation

Virginia Commonwealth Univ.

USA

Jennifer Bradley, MS, CRA

Compare personalized selection of an optimal MAP to each patient vs. standard hemodynamic
management with all having same BP goal

Univ. of Pittsburgh Schoolof Medicine

USA

Patrick Coppler, PA-C

Aim to improve initial and long-term survival & diminish neurological damage after global
ischem and reperfusion by administration of Hemarina-M101 after CA

Inselspital Bern Univ. Hospital

Switzerland

Michael Glas, MD

Hypothesize that CPR augmented by balloon aortic occlusion benefits from adaptive balloon-wealing
protocol tailored to maintain a blood pressure

Travis Air Force Base, Clinical
Investigation Facility, CA

USA

Guillaume Hoareau,
DVM, PhD

Will test the prognostic potential of LPC using an established rate model of CA and human patients

Feinstein Institute for
Medical Reaserch

USA

Junhwan Kim, PhD

Effect of MAP on cerebral perfusion & metabolism after CA in porcine

Oslo Univ. Hospital

NorwayChristina Skare, MD

Improving simulation-based medical education in pediatric resuscitation: Real-time feedback
and visual attention

Medical Univ. of Vienna

Austria

Michael Wagner, MD

Test the feasibility and yield of nanopore sequencing, as compared to culture, for assessmentof body fluid speciments from post CA patients

Univ. of Pittsburgh

USA

Alexandra Weissman, MD

Mechanisms ot pharmacological hypothermia induced by cannabinoid receptor agonist WIN55,
212-2 on outcomes of CPR

Soochow Univ. Second AffiliatedHospital (Research at
VA Commonwealth Univ.)

China/USA

Yan Xiao, MD

Amplitude spectral area to assess hemodynamic and metabolic interventions during CA

Rosalind Franklin Univ. of
Medicine & Science

USA

Salvatore Aiello, MD
PhD Student

2020: $765,317

2019: $676,368

ca
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as of January 2020

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as of January 2020

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25%

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GRANT TITLE
Intensive care knowledge translation in practice (ICU knowledge-TIP)
Targeting heme oxygenase-1 with H2 gas inhalation to improve CA outcomes

lic

tabo

/Me

lar
Cellu

RECIPIENTCOUNTRY

LEAD INVESTIGATOR

Univ. Clinical Center ofRepublika Srpska
A)
s (PE
eles
Puls forFeinstein Institutes
Medical Research

Bosnia andHerzegovina

Pedja Kovacevic, MD, PhD

USA

Kei Hayashida, MD, PhD

Mitigation of ischemia-reperfusion injury and cardiovascular collapse during resuscitative
endovascular balloon occlusion of the aorta in trauma using adenosine, lidocaine, and magnesium

Madigan Army Medical Center
Joint Base Lewis-McChord, WA

USA

Daniel Lammers, MD

Endothelial dysfunction and repair during septic shock: transcriptome analysis of circulating
endothelial cells and blood outgrowth endothelial cells by RNA-seq

INSERM U976
Université de Paris

FranceStéphanie Pons, MD

Level of soluble CD73 association with outcome, and predictive utility for post-CA cerebral edema

Maine Medical Center

USA

Jonathan Rud, DO, PhD

Sex hormone differences in CA patients

Univ. of Illinois at Chicago

USA

Pavitra Kotini-Shah, MD

Improving successful defibrillation of ventricular fibrillation in a porcine model of CA using
machine learning algorithms with physiology guided resuscitation

Li Ka Shing Knowledge Institute

CanadaRohit Mohindra, MD

Testing the impact of intra-shift naps during night shifts on blood pressure dipping and heart
rate variability among EMS clinicians

Univ. of Pittsburgh

USA

Lenny Weiss, MD

Test hypothesis that rapidly induced therapeutic hypothermia in those with acute coronary occlusion
extends the door to perfusion time from 120-240 minutes with no increase in myocardial infarct size

Univ. of Arizona

USA

Madhan Shanmugasundaram, MD

Determining the impact of telemedicine on outcomes after pediatric out-of-hospital CA

Avera McKenna Hospital

USA

Katie A. DeJong, DO

Role of electrical impedance in pseudo pulseless electrical activity

Dartmouth Hitchcock
Medical Center

USA

Alexander Lindqwister,
MD Candidate

The usage and effects of epinephrine in pseudo-PEA

Univ. of Pennsylvania

USA

Felipe Teran-Merino, MD

Impact of kynurenin pathway (KP) inhibition on survival and neurologicaloutcome after CA and CPR

Istituto di Ricerche
Farmacologiche Mario Negri

Italy

Aurora Magliocca, MD

Define subsets of pulseless electrical activity (PEA) following initial out-of-hospital
cardiac rhythm analysis using machine learning

Univ. of Pennsylvania

USA

Steven Balian, MD

Advance healthcare provider resuscitation quality using an immersive augmented reality
CPR training system

Univ. of Pennsylvania

US

Marion Leary, MD

Mechanisms of coagulation following OHCA and how influenced by post arrest careincluding therapeutic hypothermia.

Yeouido St. Mary’s Hospital,
Seoul

S. KoreaJeong Ho Park, MD, PhD

Testing hypothesis that shock burden will intensify myocardial injury

Rosalind Franklin Univ. of
Medicine and Science

USA

Salvatore Aiello, MS

Feasiblity of random allocation to active RIC vs. Sham RIC upon ED arrival following resuscitation

Univ. of Washington

USA

Emily Bartlett, MD

Investigate the pharmacokinetics of ART-123 in healthy pigs to verify that the relativelynprolonged
circulation times seen in other species will be reproduced in swine

Univ. of Michigan

USA

Colin Greineder, MD

Determine potential neuroprotective effects of dexmedetomidine

Mass. General Hospital
Simches Research Center

USA

Michael Silverman, MD

Rapid cycle deliberate practice in first five minutes training to improve team dynamics
and resuscitation skills

Northeast Ohio Medical Univ.

USA

Wendy Van Ittersum, MD

Determine whether systemic allogeneic CDC administration reduces myocardial and neurologicalinjury in swine with post-CA syndrome

Univ. of Buffalo

USA

Brian Weil, PhD

Investigate whether the three second pause in compressions is long enough to provide twoventilations when using mechanical chest compressions during out-of-hospital CA

Amsterdam University
Medical Center

Netherlands

Hans van Schuppen, MD

Establish the effectiveness of physiologically guided resuscitation by use of NIRS during CPR

Kyoto Univ. Health Service

Japan

Takeyuki Kiguchi, MD

2018: $706,057

Grants (cont’d)
GRANT TITLE

RECIPIENTCOUNTRY

LEAD INVESTIGATOR

Investigation of organ dysfunction of diabetics following CA

Aarhus Univ. Hospital

Denmark

Lauge Vammen, MD

The study of adrenaline and its effects on CA

St. Michael’s Univ.

CanadaSteve Lin, MD

Use eye-tracking technology to characterize how providers focus their visual attention during
newborn resuscitation and assess the impact of a novel resuscitation monitor

Univ. of Pennsylvania

USA

Elizabeth E. Foglia, MD

Study involving cardiogenic shock patients randomized to therapeutic hypothermia plus standard
medical care or standard medical care alone

Univ. of Chicago Medicine

USA

Jonathan Paul, MD

Test use of Coenzyme Q10 for neuroprotection in post-CA patients to mitigate mitochondrial injury

Aarhus Univ. Hospital

Denmark

Mathias Holmberg, MD

A scoping review of existing studies investigating OHCA in the Arab Gulf Region

Fanshawe College

CanadaAlan M. Batt, MICP

Implementation of a multicenter registry for pediatric ED resuscitations using video recording

Univ. of Pennsylvania

USA

Aaron Donoghue, MD

Development of multimodal monitoring and treatment protocols for high-risk post-arrest patients

Univ. of Pittsburgh

USA

Jonathan Elmer, MD

Optimizing public access defibrillation deployment incorporating hours of operation

Univ. of Toronto

CanadaTimothy Chan, PhD

Test hypothesis that therapeutic hypothermia will be anti-arrhythmic during resuscitation andimprove ROSC after VF arrest

Case Western Reserve Univ.

USA

Joseph Stephen Piktel, MD

Investigate temporal differences between asphyxial induced CA (ACA) and ventricular fibrillationinduced CA (VFCA) and its impact on myocardial and neurological injury; examine the temporalchanges in brain and cardiac ATP levels, antioxidant reserve, and the generation of reactive
oxygen species

Aarhus Univ. Hospital

Denmark

Soren Rahbek, MD

Potassium cardioplegia with calcium reversal for ventricular fibrillation arrest: a blind
randomized controlled trial

Univ. of Pittsburgh

USA

Keith Marrill, MD

2017: $193,525

2016-2014: $130,681“ Our findings with this grant have been shared with the world experts on this line ofresearch, who feel very excited regarding these preliminary findings. Thank you for
all your support; our work would not have been possible without your help!”
Daniel Lammers, MD
General Surgery
Madigan Army Medical Center
Joint Base Lewis-McChord, WA
USA

ABOUT THE FOUNDATIONThe ZOLL Foundation, Inc. was established in 2013 by ZOLL Medical Corporation, an Asahi Kasei Group Company, to promoteresearch in resuscitation and acute critical care by providing grants to support research, education and public awareness
related to improving resuscitation practices, preventing patient deterioration associated with cardiac arrest and morbidity,
and enhancing the care of acute patients to reduce mortality and morbidity. The ZOLL Foundation is a Massachusetts
non-profit corporation and a private foundation under Section 501(c)(3) of the Internal Revenue Code of 1986, as amended.
The Foundation is registered with the Non-Profit/Organizations/Public Charities Division of the Office of the Attorney
General of Massachusetts. The Foundation adheres to policies governing conflicts of interest, grant-making procedures,and records retention. The Foundation’s fiscal year ends on March 31 of each year.
The Foundation has been supported by substantial donations from ZOLL Medical Corporation, Asahi Kasei, The Packer Family
Trust, donations from ZOLL executives and employees, and ongoing contributions from members of the ZOLL and Asahi
Kasei Group companies.
The Foundation provides grants to U.S. organizations classified as 501(c)(3) public charities or private foundations, and toforeign organizations whose activities are in furtherance of the Foundation’s charitable mission to promote research inresuscitation and acute critical care. The Foundation does not provide grants for payment of overhead charges or costs
not related to the grant-related research.
The Foundation exits as an independent entity from ZOLL Medical Corporation. Its Board of Directors includes three outside
directors who are not affiliated with ZOLL Medical and four directors who are ZOLL employees or retirees.

How to Apply for a Grant
The ZOLL Foundation has bi-annual application deadlines of March 31 and September 30 each year.
Requests for support from the Foundation can be made at these designated times via a simple application. Applications, whether from an individual
or an organization, must include a reference from a health care professional recommending the project. Applicants must also disclose any conflictsof interest in accordance with their institution’s or agency’s policies.
The application is web-based at www.zollfoundation.org. All forms can be completed electronically, and materials requested uploaded, such as a
description of the proposed research, budget and details, references, professional recommendation and other associated materials. We can assist
with questions by email. Receipt of applications will be confirmed with an immediate email confirmation. Applications are reviewed bi-annually by
the Board of Directors.
Approvals are oriented toward:

Application Review Schedule• early research in new therapies or techniques;▲

The Board of Directors will respond to all proposals during two application deadlines
per year, and will on occasion request further information or have direct discussions
with grant applicants.

SPRING▲• reviews of data and information to better understand practices in the field
		 of resuscitation and acute critical care;• educational activities combined with measurement to enhance care;• promising start-up projects whose initial results may allow researchers to seek
		 additional funding from other sources, allowing for continued research that		 will require more extensive trials or scale.

JANUARYMARCH 31

MAY 31

Applications

Application
Deadline

GrantsAwardedApproved grants will be listed on the ZOLL Foundation website atwww.zollfoundation.org

FALL

Eligibility• Be a newer researcher, ideally recommended by a more established investigator• Have a formal association with an institution or agency involved in		 resuscitation or acute critical care in a medical, scientific, educational,
		 or administrative capacity• Individual applicants must not be under any professional restrictions
		 and must have all required certifications or licenses necessary to		 practice their occupation• Funds awarded will not cover institutional overhead costs

▲

▲

▲

▲

Grant applicants must meet minimum criteria:

JUNE

SEPTEMBER 30

NOVEMBER 30

Applications

Application
Deadline

GrantsAwardedContact
ZOLL Foundation
269 Mill Rd.
Chelmsford, MA 01824
foundation@zollfoundation.org

Thank YouThe ZOLL Foundation acknowledges and thanks the many researchers who have submitted applications and helped to establish thisfoundation’s activities. We regret we are not able to fund all applicants.
The Foundation also acknowledges and thanks the organizations and individuals who have and continue to contribute to the Foundation.
These contributions have ensured sufficient resources to pursue the goals we established in the formation of the organization.

Daniel Lammers: Mitigation of ischemia-reperfusion injury and cardiovascular collapse during resuscitative endovascular balloon
occlusion of the aorta in trauma using adenosine, lidocaine, and magnesium • Pavitra Kotini-Shah: Sex hormone differences in cardiac
arrest patients • Yan Xiao: Mechanisms of pharmacological hypothermia induced by cannabinoid receptor agonist WIN55, 212-2 onoutcomes of CPR • Anja Levis: CPR-REBOA: improving outcome of prehospital cardiopulmonary resuscitation with balloon occlusion of
the descending aorta • Hans van Schuppen: Investigate whether the three second pause in compressions is long enough to provide twoventilations when using mechanical chest compressions during out-of-hospital cardiac arrest • Lauge Vammen: Methylene blue for treatmentof cardiac arrest • Kimberly Johnson: Aloud real-time reading of ICU diaries for prevention of negative post-ICU psychological outcomes:
A feasibility study • Adam Frisch: Using unstructured clinical data to predict critical illness • Joshua Lupton: Derivation and validationof a clinical decision rule for the early prediction of shock-refractory VTVF out-of-hospital cardiac arrest • Colin Greineder: Investigate
the pharmacokinetics of ART-123 in healthy pigs to verify that the relatively prolonged circulation times seen in other species will
• Heidi Herrick: Delivery
be reproduced in swine
room peak performancefor neonates with congenital
Wanchun Tang, MD, MCCM, FAHA, FNIA•
anomalies Alan M. Batt: A
scoping review of existingstudies investigating OHCA
in the Arab Gulf Region
The ZOLL Foundation wishes to acknowledge the retirement of Dr.
Wanchun Tang, a pillar and a close friend of us all in Resuscitation• Daniel Rolston: Optimizing
chest compression location:
and Critical Care. Dr. Tang’s recent academic appointments have been
Is the lower sternum really
ideal? • Jeong Ho Park:at The Keck School of Medicine, University of Southern California, andMechanisms of coagulation
following OHCA and how
the Department of Emergency Medicine, Virginia Commonwealthinfluenced by post arrest
care including therapeutic
University. He is an editor for numerous publications and member
hypothermia • Charles deRoquetaillade: Impairedof many organization councils. COVID-19 restrictions have preventedagatheringofcolleagues
andfriends
tocelebrate
his
contributions.
organ repair after sepsis:role of tissue resident
We felt it an honor to salute him in our report.
macrohages and recruited
monocytes(ORISMO)His work and that of his mentor, Dr. Max Harry Weil, is known all over the world and is at• Yusuke Miyazak: Roleof hemolysis and nitricthe core of much basic science in the field of cardiopulmonary resuscitation, emergency
oxide consumption after
cardiac arrest • Jonathan
cardiac care, and critical care medicine. He has been involved in the training of over 400
Paul: Study involving
cardiogenic shock patients
Fellows, who now practice worldwide during his leadership at the Weil Institute, where
randomized to therapeutic
hypothermia plus standard
he became President in 2006. He founded and has directed a second Weil Institute in
medical care or standard
medical care alone • Rishabh
China that will add to our knowledge in these fields. He has published more than 200
peer-reviewed
papersofhiswork.
Choudhary:
Increased
mitochondrial-mediatedsurvival with improved
neurological recovery afterHis impact is especially notable in his support of young investigators and inspiring manyof us involved in these fields. He has co-convened or convened the Wolf Creek Meeting
metformin treatment forbrain injury after cardiacon
Resuscitation
16
times.
This
prestigious
invitation-only
event
was
first
convenedin•arrest Alexandra Weissman:
Test the feasibility and yield
the 1960s as resuscitation was dawning as a discipline to advance the science and theof nanopore sequencing,as compared to culture, fortechnology. It has brought leaders in the medical community and industry together sinceassessment of body
fluid speciments from post
its beginning. It has provided a unique source of cross fertilization between research,cardiac arrest patients •Rachel Beekman: Assessing
patient care, industry and technology. The Weil Institute’s Fellows have always been a
part
of
these
meetings
and
have
been
recognized
with
no
fewer
than
22
Young
Investigator
synaptic density in cardiac
arrest survivors using [11C]Awards by the American Heart Association over the years. There are just too many other•
UCB-J PET: a pilot study
Priscilla Yu: CAMeLOT
awards to begin to mention them all in this salute.
study: Cardiac arrest
prediction by machine
Dr.
Wanchun
Tang
has
been
a
tireless
contributortothescienceofresuscitation
andlearning to improve outcome
in tots • Christopher Kelly:inspired many around the world to improve care with his quiet and thoughtful wisdom
Nebulized nitroglycerin
to improve blood flow
and extraordinary knowledge.
•
during cardiac arrest
Tanner Smida: EvaluatingThank you, Dr. Tang.
neuroprotective therapies
that modulate leukocyte
infiltration into the brain
following cardiac arrest
and resuscitation • Steven Balian: Define subsets of pulseless electrical activity (PEA) following initial out-of-hospital cardiac rhythm analysis
using machine learning • Nadine Talia: Reduction of prothrombotic antibodies in COVID-19 patients who received convalescent plasma inthe clinical trial of COVID-19 convalescent plasma in outpatients (C3PO) • Praveen Chandrasekaran: A novel approach to bradycardia
during pre-term neonatal resuscitation using an ovine model of asphyxia • Francesca Fumagalli: Mitochondrial dynamics as target for
inhaled argon therapy after cardiac arrest • Rohit Mohindra: Improving successful defibrillation of ventricular fibrillation in a porcine
model of cardiac arrest using machine learning algorithms with physiology guided resuscitation • Travis Murphy: Dodecafluoropentane
to reduce ischemic-reperfusion injury in a swine model of cardiac arrest • Sumera Ahmad: Humanizing the intensive care unit (ICU):
Perspectives of patients and their families on the use of the get to know me board • Muhammad Shoaib: The therapeutic potential of
combinational Lysophosphatidylcholine (LPC) therapy in the treatment of severe injury rodent cardiac arrest • Christoph Nabzdyk:
Bioadhesive paste for instant hemorrhage control of vascular and solid organ injuries • Summer Chavez: Changes in adult out-of-hospital cardiac
arrest outcomes and contributing factors during the COVID-19 pandemic in Texas • Yan Xiao: Mitochondrial injury differs with age in rat model