Tokyo University of Science

2023/2024

Information and Societal
Center for Fire Science and Technology
Research Center for Fire Safety Science
Research Center for Space System
Research Center for Multi-Hazard Urban

Bio and Pharmacy

Research Division for Advanced Disaster

Research Center for Drug Discovery andApplied Sciences

Statistical Science Research Division
Parallel Brain Interaction Sensing division

Division of Nucleic Acid Drug Development

Division of Digital Transformation

Division of Synthetic Biology

Medical Data Science

Division of Biological Environment Innovation

Division of Smart Healthcare Engineering

Development of superior cell and
DDS for regenerative medicine

Research ＆ Development Platform ofFundamentals

Structural Materials

Research Alliance for Mathematical

Division of Composite Materials Engineering

Division of Nano-quantum Information

Division of Implementation of sustainable technology in society

Modern Algebra and Cooperation

Functional Materials
Water Frontier Research Center
Carbon Value Research Center
Division of Nanocarbon Research
Division of Colloid and Interface Science
Renewable Energy Science & Technology Research Division
Research Group for Advanced Energy Conversion

Research Centers
These are research organizations that obtain the researchfunding needed for their activities from the national
government, from local governments, and from industry
and other sources, and that carry out initiatives that are
strategically important for their research.

The Kao “Kirei” Future Open Innovation Project

Joint Usage / Research Center
A nationally selected organization for joint use /joint research open to public and funded partiallyby MEXT.

Research Divisions
These are core research organizations comprised ofresearchers selected from within TUS and from outside the
TUS in order to provide a synergistic effect. They developinterdisciplinary and cross-disciplinary“Only at TUS”research
activities.

The Open Innovation Projects
These are research organizations that
promote the co-creation of new value withthe aim of contributing to society throughboth TUS and corporations.

Building a better future with

Message from the Director
Innovation [SSI]
Disaster Prevention
Prevention on cities

The Research Institute for Science and Technology (RIST) is a cross-disciplinary research organization within the
Organization for Research Advancement that was established in 2015 as a general research institution. Its forerunner,
the Institute for General Research, was established in 1981. Education, research, and social contributions, the threepillars of Tokyo University of Science (TUS), are synergistically related, and the many cutting-edge integrated research
projects conducted at RIST play a major role in training students to take a broad perspective and create social value.
As of September 2023, one Laboratory, three Research Centers, one Joint Usage/Research Center, two Research Hubs, 19
Research Divisions, and two Open Innovation Projects are active at RIST. In all our activities, in addition to actively pursuing
basic science in various academic fields, we promote close cooperation between disciplines and conduct innovative
research by removing bureaucratic barriers both inside and outside the university. We began promoting research focusedon environmental and energy issues even before the United Nations established its SDGs (Sustainable Development Goals)
in 2015.
Since 2021, we have launched three Research Centers, two Research Hubs, and two Open Innovation Projects. Moreinformation is available below.

Functional Green Building Materials

analysis
Science and Technology
with Engineering

The Water Frontier Research Center is the successor to the Water Frontier Science & Technology Research Center(WFST), which was established under a Ministry of Education, Culture, Sports, Science and Technology branding
project in 2016 and launched in 2021. It was established as a research center to promote cutting-edge research related
to “water interfaces,” the behavior of water on material surfaces, and to provide comprehensive services forcooperatively finding solutions to problems faced by industry.
The Space System Creation Research Center was established in 2021 from a reorganization of the Photocatalyst
International Research Center (established in 2013) and the Space Colony Research Center (established in 2017). It
has been building and expanding a human resource base consisting of next-generation space scientists and engineers
capable of operating at the international level, and it has been developing technologies required for space habitation
involving water, air, food, energy, and so on to create a virtuous cycle between earth and space with a focus onphotocatalysis. It also conducts research and development on technologies necessary for humans to stay in extreme
enclosed environments for prolonged periods, and it has been developing integrated systems that encompass thescience and technologies necessary for creating future space planes as well as the legislation that governs
commercial space transportation. In 2022, the Research Center for Near-Future City Function by Terrestrial-Space
Dual Development was selected by the Japan Science and Technology Agency (JST) as an educational project (in thefield of co-creation) under the Program on Open Innovation Platforms for Industry-Academia Co-creation (COI-NEXT).
The Research Center for Drug Discovery and Applied Sciences was established in 2023 to carry on the Chemical
Biology Division Supported by Practical Organic Synthesis, which had been active until 2022, through collaboration
with researchers in the field of molecular biology. The goal of this Center is to create drugs by carrying out drug
discovery research on new substances developed by TUS using our proprietary organic synthesis technology.
One of the research hubs, the Carbon Value Research Center was developed in January 2022 with the aim of utilizing
the science and technology of the university’s faculty to develop essential chemical science and technology, such as
artificial photosynthesis, that will contribute to carbon neutrality, through collaboration and joint research withexternal organizations. The Center is developing carbon value science and technology by pursuing the science andtechnology of green hydrogen production and the synthesis of useful materials utilizing carbon dioxide as a source ofcarbon.
The other research hub, the Research Center for Multi-Hazard Urban Disaster Prevention was launched in August2023. The Center will create and implement a new science of urban disaster management that addresses
multi-hazards in which hazard chains occur across time and space causing an increase in damage, through strong
collaboration of disaster management researchers on various hazards and data science researchers. Through thisCenter, we aim to build a safe and security society in which no one is left behind in a sustainable anddiversity-conscious manner.
With our Open Innovation Projects, we aim to contribute to the creation of new value by disseminating, both inside andoutside the university, the results and findings of joint research involving both university faculty and companies. These
research activities, which could be described as “knowledge co-creation”, are expected to produce solid research
results in line with the medium-term R&D strategies of corporations and other participants. Through the Kao ‘Kirei’
Future Open Innovation Project, which we launched in 2021, we continue to recognize the roles of the respective social
missions of companies and the university while we promote the development of innovative technologies in order toenrich people’s lives. In 2022, we launched our second Open Innovation Project, the Research ＆ Development
Platform of Functional Green Building Materials, in collaboration with Shimizu Corporation. This project promotes
research and development aimed at the social implementation of environmentally friendly architecture.
Through collaboration on research across Research Centers, Research Hubs, and Research Divisions, RIST aims toenhance the fluidity and mobility of faculty personnel. By taking advantage of appealing
research environments that are rich in vitality and unity, we aim to foster highly creative,
diverse human resources who will lead the next generation of society, and to become aninternational hub for interdisciplinary research. We will also create new academic trends
and produce transparent research results in a way that is unique to TUS.

Science

Dr.Hiroshi Nishihara

Director
Research Institute for Science and Technology
Tokyo University of Science

INDEX
06 Research Center for Drug Discovery and Applied Sciences
07 Research ＆ Development Platform of Functional Green Building Materials
Joint Usage / Research Center
08 Research Center for Fire Safety Science
Functional Materials
10 Water Frontier Research Center
11 Carbon Value Research Center
12 Division of Nanocarbon Research
13 Division of Colloid and Interface Science
14 Renewable Energy Science & Technology Research Division
15 Research Group for Advanced Energy Conversion
Structural Materials
16 Division of Composite Materials Engineering
17 Division of Implementation of sustainable technology in society

Only at TUS

Bio and Pharmacy
18 Research Center for Drug Discovery and Applied Sciences
19 Division of Nucleic Acid Drug Development
20 Division of Synthetic Biology
21 Division of Biological Environment Innovation
22 Development of superior cell and DDS for regenerative medicine
Information and Societal
23 Center for Fire Science and Technology
24 Research Center for Space System Innovation [SSI]
25 Research Center for Multi-Hazard Urban Disaster Prevention
26 Research Division for Advanced Disaster Prevention on cities
27 Statistical Science Research Division
28 Parallel Brain Interaction Sensing division
29 Division of Digital Transformation
30 Medical Data Science
31 Division of Smart Healthcare Engineering
Fundamentals
32 Research Alliance for Mathematical analysis
33 Division of Nano-quantum Information Science and Technology
34 Modern Algebra and Cooperation with Engineering
Open Innovation Project
35 The Kao “Kirei” Future Open Innovation Project
36 Research ＆ Development Platform of Functional Green Building Materials
RIST Organization Chart
37 RIST Organization Chart/Campus Map

①
Research Center for Drug Discovery and Applied Sciences

Structure-Activity Relationship (SAR) and Mode of Action (MOA) Studies
Using New Compounds Developed at the Tokyo University of Science
Artiﬁcial synthesis of FE399, a natural substance derived from a fungus of the Japanese yew(a tree in the yew family): First successful synthesis of a natural substance through MNBA
macrolactamization〜 Prospects for the development of cancer drugs that inhibit the growth of colorectal cancer and other formsof cancer caused by mutations of gene p53 〜
Cancer is the leading cause of death in modern society. It is said that one in two men and one in three women will develop
some form of cancer during their lives. This makes the development of new treatment techniques and new drugs an importantsocial issue.
FE399 is a novel natural compound (Fig. 1) that has been isolated from cultures of Ascochyta sp., which is a type of fungus. It
has an inhibitory eﬀect on the growth of various tumor cells, including human colorectal cancer cells. In particular, it isunderstood that some cells, including those of colorectal cancer, esophageal cancer, and breast cancer, come about due to amutation of the p53 gene, which is a cancer suppressor gene. Thus, FE399 suppresses the growth of cancer cells formed by the
p53 mutation by promoting apoptosis in them.
In order to synthesize compounds with bioactivity that issimilar to that of natural compounds, it is essential to clarify
not only the molecular formula but also its structure andstereochemical properties. However, until now, the exact
molecular structure of FE399 was unknown, even though theprecise molecular formula was known. For that reason, theprecise structure of FE399 and the establishment of a method
for synthesizing it were long-awaited.
The Synthetic and Pharmacological Activity Evaluation Groups
at the Research Center for Drug Discover y and Applied
Sciences, RIST, TUS have determined the structure of FE399
using a synthetic chemistry approach and has established ahighly eﬃcient route for the total synthesis of FE399 by using
MNBA (2-methyl-6-nitrobenzoic anhydride), a rapid dehydration
co nd ensatio n agent that the u niversit y had p reviously
developed, utilizing a three-stage key reaction (Fig. 2).

Fig. 1.

FE399, a natural substance obtained from Ascochyta, a type of moldFig. 2.

Overview of an artiﬁcial synthesis method for FE399 using MNBA

We have clariﬁed the molecular structure of FE399 andestablished a pathway for synthesis. This is expected to
improve quality of life (QOL) in the treatment and prognosisof colorectal cancer and other forms of cancer.
At present, the Research Center for Drug Discovery andApplied Sciences is evaluating bioactive compounds thatwere seen during the synthesis of FE399. We are also testingartiﬁcial analogs of other natural substances to determine
their therapeutic eﬃcacy for treating colorectal cancer, lungcancer, and blood-related cancers. We expect the results of
t h i s re s e a rc h to m a ke si g n i ﬁ c a n t co n t ri b u t i o n s to t h edevelopment of novel future cancer drugs based on natural
substances as lead compounds.

06

Tokyo University of Science②
Research ＆ Development Platform of Functional
Green Building Materials
Achieving Environmentally Friendly Construction Through Research and Development ofHigh-Functionality Materials and Construction Methods That Help to Reduce CO₂ Emissions
In this project, we will construct a system for evaluating and visualizing CO₂ emissions related to non-structural components̶
an area in which no research and development progress has been made so far̶taking life stages into consideration, in order tocreate a society oriented toward environmentally friendly construction. We will also promote research and development ofhigh-functionality materials, including exterior materials, interior materials, entrance components, and foundation materials, aswell as construction methods that help to reduce CO₂ emissions during manufacturing and construction.
In order to reduce the burden of buildings on the environment at a time when eﬀorts to eliminate carbon are increasing throughout society,
it is crucial to establish an academic foundation for achieving environmentally friendly construction at a high level and to develop acomprehensive platform for encouraging the implementation of those goals in society. In particular, non-structural components forapproximately 20% of the CO₂ emitted as embodied carbon during
the construction. However, despite individual studies and societal
Architecture and Global Fire Science
Architecture
and Technology
attempts from an environmental conservation perspective, there(materials)(ﬁre protection and resistance)
has been lit tle holistic at tempt to o p t i m i z e t h e o v e ra l lenvironmental impact of buildings.
An OpenIn order to reduce the environmental impact of non-structuralcomponents, we need to consider whole life carbon̶thetotal amount of CO₂ emissions produced during a building's
life cycle, including embodied carbon as well as operational
carbon, which is the amount of CO₂ emitted during the operational
stage of a building. However, at present, there is no establishedmethod for assessing whole life carbon. Another issue is thatin the case of non-structural materials, unlike structural
materials, there has not been adequate preparation of thebasic information that would be indispensable for making
precise calculations of embodied carbon, taking into accountthe eﬀect of diﬀerences in material processing treatments onenvironmental impact, the eﬀects of reducing environmental
impact through the use of recycled materials, and other suchfactors.
In this project, we will develop a system for evaluating andvisualizing the CO₂ emissions of non-structural components foreach life stage, and we will promote research and developmentof materials and construction methods that achieve a highdegree of compatibility between environmental performanceand functionality with regard to exterior materials, interiormaterials, entrance components, and foundation materials̶
items that have a high level of impact on whole life carbon. We
will also contributeto nature-positivity, encouraging research
Resource conservation
Conserving materials and streamlining
and development
directed toward high-functionality
andlifeLonger service
structural engineering methods
Ensuring highdurability
Developing surface ﬁnishinghigh-performanceinterior
andexteriorbuilding
materials
thattechniques
to ensure freedom of design
Reducing deterioration andalso promotes resource conservation and recycling.
controlling the eﬀects
High insulationof aging through structural
engineering methods

By promoting
this industry-academia collaboration project as
Embodying energy-saving
exterior materials
a comprehensive initiative based on open innovation, theUsing exterior materials thatto energy conservation
project's contribute
members
intend to create pioneering examples in abyreducing the energy requiredfor heating and cooling during the
Wood utilization
operational stage
w i d e ra n g e o f b o u n d a r y re g i o n s a n d l e a d t h e
w ay i n
Encouraging the use of wood
Resource recycling
environmental
conservation eﬀorts within the construction
Making improvements that
Circular economy
encourage the utilization ofwood
industry.
Proactively utilizing recycled
aluminum and steel

Innovation Project
involving approximately
25 people

Industrial andSystems Engineering

Pure and Applied Chemistry
Architecture(environment)This project is an Open Innovation Project conducted by Tokyo University of Scienceand Shimizu Corporation.

Resource conservation
Conserving materials and streamlining
structural engineering methods
Developing surface ﬁnishingtechniques
to ensure freedom of design

High insulation

Longer service life
Ensuring high durability
Reducing deterioration andcontrolling the eﬀects
of aging through structural
engineering methods

Embodying energy-saving
exterior materials
Using exterior materials that
contribute to energy conservation
by reducing the energy requiredfor heating and cooling during theoperational stage

Resource recycling
Circular economy

਽౫ણ৷
Wood
utilizक़ॵॻ‫؞‬ই॓‫ش‬५
Encouraging
the u਽౫भ஋ாਹ
Actively
using

ৈ૵೸৲
High
insulaWood utilization
Encouraging the use of wood
Making improvements thatencourage the utilization ofwood

Improving the perf
foundation mateৣ৉౫ृ૵೸౫भਙ
insulation ma

Using interior mat
contribute to energyઈ৷஺మभഐ཮ඬ
by reducing the energ
heatingand cooling੄ग़ॿपఞଖघ
operational s

Proactively utilizing recycled
aluminum and steel

਽౫ણ৷
Wood
utilizationक़ॵॻ‫؞‬ই॓‫ش‬५ॺ
Encouraging
the use of wood਽౫भ஋ாਹ৷ष
Activelyusing wood

ৈ૵೸৲
High
insulation
Improving the performance offoundation materials andৣ৉౫ृ૵೸౫भਙચ਱঱ष
insulation materials

Using interior materials that
contribute to energy conservationઈ৷஺మभഐ཮ඬਗ਼ৡ॑చ੖
by reducing the energy required forheatingand cooling during the੄ग़ॿपఞଖघॊ৔ಎष
operational stage

Examples of eﬀorts aimed at achieving environmentally friendly construction

Tokyo University of Science07

Joint Usage/Research Center

Established: July, 2009

kasaianzen-ml@tusml.tus.ac.jp

Director
Professor,
Graduate School of Science andTechnology, Department of Global
Fire Science and Technology

Research Center for Fire
Safety Science
Research Center for Fire Safety Science is currently promoting formation ofresearch and education center, and produced two major outcomes, one is thedevelopment of“theory”pertaining to performance-based fire safety design, andthe other is the development in“practice”through experimental research utilizing
the full-scale experimental facilities. Upon these two pillars, the Center will

Open Call Schedule

Ken Matsuyama
Dr.Eng.

further research and deepen our knowledge of how to control the potential firerisks that are increasing along with the emergence of new spatial configurations(high-rise or underground) and use of new materials (e.g. aluminum and plastics).
These are inevitable changes brought about by modernization, industrializationand increased need of energy conservation.

Management Structure and Assessment Procedure

The Center invites and accepts research plans from public basically once a
year research activities of the selected plans start at the beginning of eachacademic year. However, research of urgency may be accepted at any pointof an academic year as needed.
The rough schedule of the application is as follows:● Announcement of the theme：early February● Application period：February to mid-March● Notification of acceptance：March to April● Conducting collaborative research：April to next March● Briefing report of achievement：by next April

The Research Center for Fire Safety Science Committee“(the Committee”),
playing the central role in the Center, consists of a chairperson and 10
members (5 from inside and 5 from outside of TUS).
The Committee is the supreme decision-making body of the Center thatdevelops a research and operation policy, formulates a management policy(including budget drafting), and plans research projects such as deciding atheme to call for entries.
Aiming to support smooth operation of the Center, the Research Theme
Selection Committee and two special committees (called Working Groups or
WG) are placed under the Committee. The Research Theme Selection
Committee and two special committees function as follows respectively:
The Research Theme Selection Committee

Reference Research Theme[General Category, A ～ F]
A. Fundamental research on building fire safety(Examples from the past)◦A n experimental study on measurement method and estimation
algorithm of radiant heat flux from large scale facade fire
B. Fundamental research on material combustion science◦Measures for controlling fire propagation at the surface of wooden linings◦An investigation of the measurement methods of lateral flame spreadrate over wall lining materials◦F T-IR/Thermal Decomposition Analysis of Surface Combustion
Characteristics in Flame Retardant Cross-Laminated Timber with
Intumescent Nano-Clay Composites
C. Fundamental research on fire safety and disaster prevention◦An Experimental Study on Fire Prevention Effect with High Viscosity
Liquid on A Wood Board
D. Fundamental research on large-scale fire
E. Research on technology and measures pertaining to fire safety
F. R & D issues that can be expected for technological innovation to reducefire risk[Emphasis Category, G]（※）
G. Experimental Research on Building Structural Fire Resistance（※）Large-scale experimental challenge to use Structural Fire ResistanceFurnace, or Multiple Full-scale FurnaceThis committee makes judgment on acceptance or rejection of
applications received. Judgment will be made considering whether the
research objective is defined clearly, the plan and the methodology areappropriate, proposed budget is reasonable, and whether the researchoutcome has potential for further development.
Facilities and Equipment Control Committee (WG)
This committee (WG) is primarily involved in the operation planning of the
full-scale experimental facilities. It is also responsible for the maintenance offacilities and equipment installed in the institution. In addition, it gives users
instruction on how to use these facilities and equipment and on safetycontrol.
The Research Theme Planning Committee (WG)
This committee (WG) draws out research themes and projects that areappropriate for the collaborative use or research and that serve the purposeof the Center and fulfill a social need.
The Assessment Committee
This committee functions as an assessing body of the Center by providing
interim and ex-post evaluation on the progress and outcome of research
projects.

Research Institute for Science and Technology

Center for Fire Science and Technology

Research Center for Fire Safety Science
The Research Center forFire Safety Science Committee

The Assessment
Committee

The Research Theme Selection Committee
Facilities and Equipment Control Committee (WG)
The Research Theme Planning Committee (WG)

(Management Structure)

08

Tokyo University of ScienceExample of Available Facilities/Equipment

Cone Calorimeter Testing Device (ISO 5660)

FTIR Gas Analyzer

ICAL Testing Unit (Heat Radiation Panel)This device is used to examine ignitability and the exothermal
properties of construction materials using thermal radiation. A
test object is placed under the conical-shape electric heater,which controls the thermal radiation to the object, and a pilot
flame, is applied to the object 10mm from its surface. The ignition
time and the heat release rate can be measured per thermalradiation that can be set in the range of 0 to 50 kW//m2.

This unit is designed to be connected to the combustion andsmoke generation tester and enables high-speed and continuous
analysis of combustion gas. A measured value can be updated atshort intervals (five to ten seconds). This unit specializes inmeasuring certain types of gas that is result from combustion in
fire.

This unit is designed to elucidate the burning behavior of
combustible materials under the condition where a certain heat
flux was given through radiative heat transfer. The unit can also
be used to investigate the behavior of members exposed toradiative heat. The panel heater has a heating area of 1.75 m (W)× 1.38 m (H). Members can be exposed experimentally tosurface temperatures up to 950 and a heat flux of 50 kW/m2.

Calorimetry Hoods (5 m × 5 m)

Full-Scale Compartment for Fire Experiment(with Water Pump)

This unit is used to analyze the burning characteristics of furnitureand equipment in a room by burning them and collecting theburning gas. The duct is equipped with devices for flow
measurement and sampling. The design heat release rate is 2
MW at maximum, and the smoke suction power is 600 m3/min at
maximum. A movable unit (4 m × 4 m) is also available.

This fire compartment is 6 m (W) × 6 m (D) × 2.7 m (H) in actual
size, and the sprinkler system can be attached to the ceiling. The
compartment is mainly used to evaluate the fire extinguishing
performance of sprinkler systems and also has used forexperiments on smoke movement during sprinkler system
activation.

Structural Fire Testing Furnace(Medium scale)

Structural Fire Testing Furnace(Large scale, for Walls)

This unit is used to evaluate the fire-resistive performance ofvarious structural members such as columns, beams, floors andwalls. The unit can control the heat to the standard heating
temperature and furnace pressure set by ISO 834.The heating
furnace, with dimensions of 1.5 m (W) × 1.5 m (D) × 1.5 m (H),can also provide immediate heating.

This unit is used to evaluate the fire-resistive performance of an
exterior wall under fire and can control the heat to the standard
heating temperature and furnace pressure set by ISO 834. Thereare 20 burners on the lateral side, and this can heat up to a 3.5 m
× 3.5 m area. The unit is also suitable for performing heat tests.

Room Corner Testing Unit (ISO 9705)
This unit is comprised of a space of 2.4 m (W) × 3.6 m (D) × 2.4 m(H) (approximately, the size of a 6-tatamimat room) and an
opening 0.8 m (W) × 2 m (H). It can be used to recreate a fire ina room with furniture and dry walls, which can be developed intoa fully developed fire.
In addition, flashover experiments can be performed with this unit
by recreating fires that spread to entire rooms in a short time
period, and then combustible gas concentration and temperature
distribution data can be collected. The development of the fire
can be captured by video camera.

Multiple Full-scale FurnaceThis device is used to measure the fire-resistive duration ofhorizontal materials of buildings including beams, floors and roofs
by using the standard heating test (ISO834). Fire-resistive
performance of any kind of horizontal materials can be evaluatedby the heating test using this device. Put a full-scale model of 3 m(W) × 4 m (D) on the top the heater like covering it and then turnon the burner to heat the model from beneath.

Tokyo University of Science09

Functional Materials
Established: April, 2021

watus@rs.tus.ac.jp

Director
Professor,
Department of MechanicalEngineering,
Faculty of Engineering

Water Frontier Research Center(WaTUS)

Masahiro Motosuke
Ph.D

Objectives

To discover principles and mechanisms of interaction between water andmaterials surface including how to control them by interdisciplinary researchcollaboration.

Future Development Goals

To promote advanced researches on water interface by collaboration, and toform a research organization offering one-stop service for water science andtechnology.

Water is one of the most familiar substances but
there are many unexplained issues, especially aroundthe interface with materials surface. We, WaTUS,
tackle these researches relating to“water interface”
by interdisciplinary approaches and aim to provide
practical solutions to industries as well.

Core of excellence for research and development of “Water Interface”
Background“Water”is one of the most essential substances which supports our basisof lives in various forms, and we, not only the human being but also all thelife cannot survive without the benefit of water. It plays crucial roles totransfer oxygen, nutrition and waste, and to assist structuring and fulfillingcells, tissues and organs. Additionally, in industrial fields, it is of importancein drinking, cleaning, immersion, coating and so on. So, it is no exaggeration
to say that water is the longest and most frequently used substance in our
history. However, there are still plenty of unexplained issues in its properties,
performance and function; especially, interaction between water andmaterials’surface, namely“water interface”, is generally very complicatedand particularly difficult to be fully understood (Fig. 1).
To tackle these issues, a former research center, Water Frontier Scienceand Technology Research Center (W-FST) was launched on November 2016.
Through research activities of W-FST, it is found that the topic of“waterinterface”is crucial and is highly needed both for academics and industries.
Then we concluded to keep our continuous challenges and progresses tothese issues by expanding and deepening the fields. Then, the successive
research center “Water Frontier Research Center (WaTUS)” has been
established after the reorganization on April 2021 to highly promote ourresearch activities. The logotype of our center (Fig. 2) represents“water”
encompassing its molecule, nature of continuum, and interfacical behavior.

Materials and Water :	this unit pursues research and development
considering relation between water and materials
from atomic to macroscale.
Life and Water :	this unit pursues research and development
contributing to human beings and medical
diagnostics or medical and biological engineering.
Environment and Water :	this unit pursues research and development forenvironment and industries. Earth science andenergy conservation is also included in this unit.
In addition, events such as the Water Frontier Symposium and evening
seminars are held to promote the output of research activities and enhancemutual exchange among related researchers.

Our mission
We, WaTUS, aims to pursue leading-edge researches and developments

relating to“Water Interface”with multi-disciplinarily collaborative researches.
Our mission is to perform following missions (Fig. 3);( i ) Pursuit of state-of-the-art science and technologies of water interface bycollaboration and technical excellence( i i ) Establishment of international research core of excellence( i i i ) Provision of“one-stop service”of water researches for industries( i v ) Visualization of TUS through our research activities
Formation of research and development hub for“Water Interface”throughour researches means to create the place where researchers all over theworld can join and to establish research organization which can provide
practical solutions to industries.
To carry our above-mentioned missions, highly intensive collaborations offundamental researches and technical developments with researchers insideand outside of the center become a key.

Fig. 1 Various phenomena and applications of“Water Interface”from atomic/
molecular scale to macroscaleFig. 2 Logo of Water
Frontier Research Center(WaTUS)

Fig. 3

Research organization of WaTUS
WaTUS promotes interdisciplinary collaborative researches to achieve ourgoals. We consist of matrix-based research units with approaches (Materials
development, Measurement & Analysis, and Theory & Simulation) and targets(Materials & Water, Life & Water, and Environment & Water). In this 3 x 3matrix-based research unit (Fig. 4), our center encourages researchers whodevelop novel materials with high functionality, ones who develop cuttingedge measurement and analysis techniques, and ones who perform
advanced theoretical consideration and simulation, to perform intensively
flexible collaborative studies expecting synergetic effects. Also, more flexible
style of collaboration involving ones outside of the center are appreciated inthis center.
Fig. 4

10

Tokyo University of Science

Matrix-based research units in WaTUS

Strategies of WaTUS

Functional Materials
Established: January, 2022

a-kudo@rs.tus.ac.jp

Director
Professor,
Department of Applied
Chemistry, Faculty of Science
DivisionⅠ

Carbon Value Research Center

Akihiko Kudo
Ph.D. (Science)

Objectives

We aim at developing technologies based on basic researches for green H 2
production and CO2 utilization by converting it into valuable products.

Future Development Goals

We will contribute to achievement of carbon neutral and solution of resource,energy and environmental issues we are globally facing.

For a carbon neutral society, it is indispensable todevelop technologies utilizing CO2 as a carbon sourcefor production of valuable compounds. Our CV center
study science and technology using photocatalysts
and batteries that are our strong research fields for
the CARBON VALUE that contributes to the solutionof resource, energy, and environmental issues.

Carbon value beyond carbon neutral ~ Green H2 production and CO2 utilization ~Background of the establishment
Due to the concern about climate change and global warming, themovement toward decarbonized society is being accelerated globally. In
October, 2020, Japanese government announced that Japan would achieve“Carbon neutral” (i.e., net emission of greenhouse effect gas is zero in total)
by 2050. The Green Growth Strategy, which connects challenges for carbon
neutral with an economical and industrial growth, was formulated. In 2021,
the summit among university’s presidents on the contributions toward
carbon neutral was held and, based on the discussion done here, “University
Coalition for Carbon Neutrality” was established.
Based on the social background mentioned above, our university ranked
research fields relating to “carbon neutral” as a strategical key area, and then
“Carbon Value Research Center”, where researchers on artificial
photosynthesis, electrochemical CO 2 reduction, secondary batteries,hydrogen usage gathered, was launched in January, 2022.

Aims of our CV center
The CV center develops original and essential technologies for CARBONVALUE by which CO2 is converted to valuable products as a carbon source
through collaborations. The CV center aims to solve the resource, energy,
and environmental issues by social implementation of the total system basedon our basic research through the carbon value technology.

Main research topics in our center• Manufacturing of highly-valuable products by CO2 reduction
To manufacture highly-valuable products (i.e., gasoline, jet fuel, olefin, andalcohol) from CO2 as a carbon source, we work on the development of CO2
reduction technologies. CO2 reduction by artificial photosynthesis using sun
light, H 2O and photocatalysts/semiconductor photoelectrodes, and anelectrochemical reaction of CO2 with renewable electricity are studied forthe direct CO2 reduction.
• Green hydrogen production with renewable energy
Hydrogen is also an essential material from a perspective of carbon neutral.
Because hydrogen burns without emitting CO 2, it is attracted as a clean
energy source. In addition, hydrogen is indispensable as a basic material in achemical industry. Today, an industrial production of hydrogen is based on asteam reforming method, in which fossil fuels (i.e., petroleum, natural gas,and coal) are reacted with water at high temperature. Therefore,
consumption of fossil fuels and emission of CO 2 are still remaining. To
achieve carbon neutral, technological development of green hydrogenproduction from water with renewable energy is desired. Our CV center
conducts the research on artificial photosynthesis in which green hydrogen is
produced by water splitting using a photocatalyst that is the strength of ouruniversity. The green hydrogen can be utilized for a carbon value technology
such as hydrogenation of CO2 to produce valuable compounds in a chemicalindustry.
• Development of batteries supporting carbon neutral society
When green hydrogen is considered as a clean energy, the application to afuel cell technology becomes important. Our CV center works on reduction
in an amount of platinum and even platinum free in fuel cells, because
platinum is rare and expensive. A secondary battery to store renewableelectricity is also a key technology for green hydrogen production and CO2
reduction by electrochemical reactions. Developments of not only lithium but
also sodium ion battery are important from a view point of stable supply of
the alkaline metal resource. The secondary battery contributes to carbon
neutral in an electric vehicle.

Fig. 1

Future vision that our CV center aims

Research system of CV center
About 10 researchers from Tokyo University of Science belong to the CV
center. The researchers collaborate with each other and also outside
researchers. We work on developments of photocatalysts andsemiconductor photoelectrodes for artificial photosynthesis, electrocatalysts
for electrochemical reduction of CO 2 using a renewable electricity, andsecondary batteries for storage of the renewable electricity, and minimizationof platinum in a fuel cell for usage of green hydrogen. In addition, life cycle
assessment (LCA) simulation, CO2 storage and adsorption, biological process,and measurement technology are also studied. The collaboration will be
expanded to accelerate the research in the future.

Fig. 2

Research topics in our centerTokyo University of Science11

Functional Materials
Established: October, 2012

takahiro@rs.tus.ac.jp

Director
Professor,
Department of Physics,
Faculty of Science DivisionⅠ

Division of Nanocarbon Research

Takahiro Yamamoto
Ph.D.

Objectives

To investigate novel properties relating to carbon nanotubes and graphene,
and to develop material sciences utilizing the nanospace of nanotubes and theinteraction between nanotubes and various molecules.

Future Development Goals

To promote advanced researches on nanocarbons based on tight and highly
active collaborations of division members.

Nanocarbon is an active research field with increasing
publications. Our research division is unique in that
advanced researchers of nanocarbons are getting
together and perform researches with wide scopes.
In particular, tight collaborations between theorists
and experimentalists are our strength. We are aiming
at creating new fields and technologies based on our
researches.

Research and development on carbon nanotubes and graphene.
Carbon nanotubes and graphene are low dimensional materials (withlinear and flat shapes, respectively) composed of networks of 6-members
rings (honeycomb structure). Owing to strong covalent bonds of carbon
atoms, they have excellent mechanical strength and chemical stability
enough to sustain the monolayered structure in a free space. Furthermore,they exhibit properties peculiar to the geometrical configuration and low
dimensionality, which cannot be expected for three-dimensional crystals. As
you can see from the fact that the Nobel Prize in Physics 2010 relates tographene, nanocarbons such as carbon nanotubes and graphene areextensively studied in basic science. In the future, nanocarbons are expected
to play a main role in an industrial revolution as iron and silicon did in the
Industrial Revolution and the information technology revolution, respectively.
The Division of Nanocarbon Research covers topics of nanocarbons fromfundamental to applied researches by collaboration of experts in theoretical

Research topics
Materials Sciences in Nanospace・We use an individual single-walled carbon nanotube as a well-definednanospace, and study the interactions between nanotubes and molecules
such as water and alcohol by optical spectroscopy, electron microscopy
and molecular dynamics simulations. Thereby, we elucidate the structure
and phase of the molecules in the nanospace. We also study theinteraction between nanotubes and polymers, aiming at application ofpolymer-nanotube composites.
・We regard systems composed of nanotubes with adsobates or defects asextended composites, and study the basic properties by first-principles
electronic state calculations and model calculations.

and experimental condensed matter physics, electrical engineering, thermal
engineering, and biophysics. We expect synergy effects by enhancing mutual
discussion and exchange of ideas in the division.

Nanotube-Hybrid Materials
・We study structural properties of composites composed of nanotubes andbiomolecules (DNA, protein). Specifically, we fabricate biodevices withhorizontallyalignednanotubes functionalized by DNA, and examine whether the structuralproperties of the biomolecules are retained, and whether the molecular
recognition function is retained.
・We theoretically investigate the host-guest interactions of the nanotube/
biomolecule composites, and clarify the effect on the properties of thecomposites.
Growth Control of Nanocarbons
・W e develop techniques for precise structural control of nanocarbons
based on the various nanotube synthesis techniques such as verticallyaligned growth on silicon and silica substrates and horizontally-aligned
growth on quartz substarte.
・We study novel synthesis methods of nanocarbons utilizing arc discharge
by changing the discharge ambience, electrode materials, etc. We also
study novel methods for graphene synthesis.
Properties and Functions
・We develop the physics of energy conversion based on nanocarbons andits application.
・We establish the basic science for nanocarbon-based paper electronics.

12

Tokyo University of ScienceFunctional Materials
Established: January, 1981

mhashizu@ci.tus.ac.jp

Director
Professor,
Department of Industrial
Chemistry,
Faculty of Engineering

Division of Colloid andInterface Science

Mineo Hashizume
Dr. Eng.

Objectives

To play a leading role in colloid and interface science both in Japan and theworld.

Future Development Goals

Promoting researches on “experimental and theoretical elucidation of the
dynamic behavior of interfaces” and “construction of new functional interfaces”
in collaboration with different fields such as chemistry, physics, biology, andmechanical engineering.

It may be said that knowledge in the field of surface
and interface science is necessary to understandall tangible“things”. We aim to utilize the strengthsof the group of experts in various fields related tointerface science, not only to connect the results
obtained to the development of next-generationmaterials, but also to pioneer new academic fields.

Basic and applied researches on phenomena at various interfaces
Interface science is a field of study that deals points, lines, surfaces, and volumes(spaces), and uses geometry such as dimensions, sizes, shapes, boundaries, front
and back, and connectivity as elements, and comprehensively systematizes these
phenomena. In particular, interface science deals mainly with“particles”(all three
dimensions are colloidal dimensions),“lines (wires)”(two dimensions are colloidal
dimensions), and“membranes”(only one dimension is colloidal dimension), whereat least one of the three dimensions is a colloidal dimension (1 nm - 1 μm), making
it a unique academic field that deals with a wide range of research topics. Thisdivision views the interface as a“spatio-temporal functional expression field that

integrates different fields”. Starting from the verification and demonstration of
conventional interface theories, we aim to create new physical properties,functions, and theories, and ultimately develop unprecedented novel functional
materials. Specific research targets are diverse, include soft (mainly organic)
materials, hard (mainly inorganic) materials, nanomaterials, and biomaterials.
We promote projects from both basic and applied perspectives.
Tokyo University of Science has traditionally had laboratories specializing in“interface science”on each campus. The Division of Colloid and Interface
Science was established in 1981 by the researchers specializing in this fields, andhas been active as a cross-campus and cross-departmental research center, andits activities are widely recognized in Japan and around the world. The first
Director, Professor Kenjiro Meguro (Faculty of Science Division I) was succeededby Professor Tamotsu Kondo (Faculty of Pharmaceutical Sciences), Professor
Minoru Ueno (Faculty of Science Division I), Professor Kijiro Konno (Faculty ofEngineering), Hiroyuki Ohshima (Faculty of Pharmaceutical Sciences), Professor
Takeshi Kawai (Faculty of Engineering). Since 2018, Professor Hideki Sakai(Faculty of Science and Technology) has led the division as the director. In themeantime, the division had been shifted to the Center for Colloid and Interface
Science during FY 2008-2012, because a project application was accepted as
the MEXT Program for the Development of Strategic Research Bases.
We would like to introduce our recent activities. In FY 2013-2017 (Director:
Prof. Kawai), we divided the research subjects of interface science into two
major areas, soft and hard interfaces, and worked to deepen our understandingof dynamic interface phenomena. The soft and hard interfaces here are different
from the general definition that distinguishes between then by the substancesthat make up the interface. A“soft interface”is a dynamic interface in which themolecules (atoms) forming the interface are constantly replaced during normal
observation time, such as micelles (molecular assemblies) of surfactants. On theother hand, a“hard interface”is a rigid interface in which there is (almost) no
replacement of surface constituent molecules (atoms), such as metal
nanoparticles. The division members were divided into groups dealing with“softinterfaces”and“hard interfaces”, and each interface was further classified into
one-dimensional, two-dimensional, and three-dimensional interfaces. We
promoted accurate understanding of the phenomena at the interface and“manufacturing”research using interface science (Fig. 1). The distinctive featureof this division is that researchers who conduct research on the theme ofinterface science from the aspects of chemistry, physics, bioscience, theoreticalchemistry, etc., to carry out research from basic to application on interface
phenomena through mutual information exchange and collaboration, while being
conscious of“dynamics of interfaces”and“dimensionality of objects”. Throughthe collaboration of the members, we were able to achieve synergistic results,
especially with regard to“stimulus-responsive interfaces that respond to external
stimuli such as light, temperature, and electricity”.
In FY 2018-2022 (Director: Prof. Sakai), the researchers who specialize inphysics, mechanics, pharmacology, theoretical science, and measurement
science joined the membership, which was previously mainly consisted ofchemists. With the support of advanced measurement science and theoreticalscience, we have set a new goal of conducting“accurate understanding of theinterface dynamics/reaction mechanism at the interface” regarding“manufacturing using interface science”. Especially in the fields of“advanced

Figure 1

Figure 2interface measurements”,“stimulus-responsive materials”, and“biofunctional
interfaces”, we were able to achieve many results, including collaborations
among members with different specialties. We also strengthened our ties withindustry by actively holding seminars by corporate researchers. In addition, we
contributed to public outreach, such as by cooperating with open colleges.
From FY 2023, together with the new members, we will promote researchdevelopment with a focus on“dynamics at interfaces”as the most important issue,
based on the achievements accumulated by the division so far. For example, inunderstanding the dynamic functions of materials formed by molecularassemblies, we will understand the linkage of“dynamics of molecules”→“dynamics
of molecular assemblies”→“dynamics of functions of molecular assemblies”and link
this knowledge to the“creation of functional materials”based on new ideas. In
addition, we will promote activities aimed at turning our university and thisdivision into an international research base in interface science research, throughactive dissemination of our results overseas, participation in international
conferences, and collaboration with overseas universities.
Regarding the operation of the division, we have set“advanced interface
measurements/theoretical analyses”,“stimuli-responsive interfaces”, and“biointerfaces”as priority themes, and promote research development with anawareness of collaboration between members while utilizing their specialties(Fig. 2). In particular, we will promote further collaboration between experts inboth materials fabrication and theory in order to understand and utilize
dynamics at interfaces as described above. In addition, we will work on creatinga system that feeds back the results obtained in one material system to othersystems and utilizes them. We will develop the results of“only at TUS”
, andintegrate collaborations within the group, and in the future, we will open up
new research areas by the entire division and lead to the acquisition of external
research funds. We will also continue the cooperation with industry that wehave cultivated so far, and promote activities such as seminars. As forinternational activities, we aim to effectively coordinate the efforts of individual
members so far and develop the division into an international base.

Tokyo University of Science13

Functional Materials
Established: April, 2020

solar@rs.tus.ac.jp

Director
Professor,
Department of ElectricalEngineering,
Faculty of Science and Technology

Renewable Energy Science &Technology Research Division

Mutsumi Sugiyama
Ph.D.

Objectives

To propose a foundation for stable and low-cost power supply/management,
and to activate and promote research, development and education of renewableenergy utilization technology at TUS.

Future Development Goals

Through ac tive interac tion among the Division members from dif ferent
backgrounds, we will promote both internal and external joint research tocreate novel concepts for renewable energy technology.

In response to the trend of times, this division iscreated by reorganizing the Photovoltaic Sci & Tech
Division established in 2010. We are composed ofmembers from different fields of expertise in various
renewable energy devices and systems. We willdevelop unique renewable energy and integrated
systems/infrastructures such as solar-wind-biomass
power generation.

Research and development on renewable energy andsystems such as solar, wind, biomass etc.
To solve the global warming problem, the biggest issue for humankind in
the 21st century, it is necessary to substantially shift the energy sources fromfossil energy such as coal, oil and natural gas to renewable energy. With thisbackground, the predecessor Solar Power Generation Technology Division
had worked to promote research of the University on solar power generation
by disseminating the research results in Japan and worldwide, tackling the
global warming problem. Meanwhile, in today world, there is a wide varietyof research and development ongoing on“renewable energy”beyond solar,
such as wind power, biomass power generation and fuel cells. In addition, at

the time of the establishment of the predecessor Division, the power supply
was simply based on nuclear power to provide a stable base power andthermal power generation to supplement the fluctuation of demand.
However, nowadays many types of renewable energy are connected to thegrid and the operation of the system infrastructures for stable power supply
has become highly difficult and critical. We have therefore reorganized theDivision, which previously focused only on solar, to include the entire“renewable energy”, and defined the purpose of the new Division as following:( i ) Development of power generation materials that reduce the installationand operation costs to the same level as power generation by fossil fuels.
( i i ) Development of highly efficient management technology for electric
power from various power generation methods.
( i i i ) Development of new materials and new system technologies.
( i v ) Collaborations between our research division and external research institutes.

Research Activities
As a research and development hub for renewable energy technology, we
will realize novel renewable energy materials and power generation systems
through vertical integration of technologies, as well as educate the next
generation of researchers and disseminate the technology to society.
Specifically, the following activities will be carried out:
• Renewable energy materials group:( i ) Proposal of ultra-high efficiency power generation device by tandem
configuration of thin film solar cells/thermoelectric generation elements.
( i i ) Establishment of hydrogen production technology using solar cell thinfilms and charging technology such as supercapacitors.
( i i i ) D evelopment of ultra-low-cost solar and fuel cell materials andmanufacturing methods, and examination of their common basic technology.
• Energy management group:( i ) Development of technologies of failure diagnosis, remote diagnosis,
power generation prediction and AI utilization for energy loss control.
( i i ) Integration of smoothing technology development for wind × solar power
generation and power storage technology such as batteries and flywheels.
( i i i ) Solar matching for agriculture and application of renewable energy
technologies to smart houses.

Members of the Division
The Division consists of 19 members listed as follows, who all havedifferent fields of expertise in physics, chemistry, electrical power, electronics,
materials and management. We are gathered together to deepen thediscussion on the development of renewable energy utilization technology
and aim for major developments through synergistic effects.

Design and evaluation on renewable energy
system utilizing regional characteristics

Renewable energy recovery system assuming
a blackout due to a disaster

Monitoring of output power from multiple small
wind turbines, and a prototype of a flywheel
energy storage system

Polymer electrolyte membrane fuel cell andautomatic humidity control system for supply air

Bio-photovoltaics using photosynthetic proteinsfrom algae

Photofunctional metal complex and catalytic
enzyme for biofuel cell

Table Members of Renewable Energy Science & Technology Research Division
Affiliation of key role

Main research field

Professor/
Director

Faculty of Science and Engineering,
Department of Electrical Engineering

Semiconductor material engineering /Thin film solar cell

Takashiro
AkitsuProfessor

Faculty of Science Division II,
Department of Chemistry

Coordination chemistry /Photofunctional fuel cells of organic/
inorganic hybrid materials

Zhao
Xinwei

Professor

Faculty of Science Division II,
Department of Physics

Semiconductor nano-material engineering /Thin film photovoltaic cellYuzuruUeda

Professor

Faculty of Engineering,
Department of Electrical Engineering

Electricity and energy engineering /Photovoltaic system

Morio
NagataAssociate
Professor

Faculty of Engineering,
Department of Industrial Chemistry

Organic photovoltaic cell /Artificial photosynthesis

Junji
KondohAssociate
Professor

Faculty of Science and Engineering,
Department of Electrical Engineering

Photovoltaic power system /Wind power generation /Power conditioning system

NoboruKatayama

Associate
Professor

Faculty of Science and Engineering,
Department of Electrical Engineering

Fuel cells / Hydrogen storage /Diagnosis for energy devices

Takashi
Ikuno

Associate
Professor

Faculty of Faculty of Advanced Engineering, Surface and interfaces /Department of Applied Electronics
Photovoltaic devices / Nanogenerators

TomoyukiHaraguchi

Junior Associate Faculty of Science Division II,
Professor
Department of Chemistry

Coordination chemistry /Dye sensitized solar cell

Yuka
TakagiJunior Associate Faculty of Science and Engineering,
Professor
Department of Electrical Engineering

Ferroelectric Materials,
Energy Storage, Metamaterials

DaisukeNakaneAssistant
Professor

Faculty of Science Division II,
Department of Chemistry

Coordination chemistry /Bioinorganic chemistry / Catalytic chemistry

Cui
JindanAssistant
Professor

Faculty of Engineering,
Department of Electrical Engineering

Photovoltaic system /Energy management system

Kohei
Terashima

Assistant
Professor

Faculty of Engineering,
Department of Architecture

Solar heat utilization /Photovoltaic system

Yoichi
HirataVisiting
Professor

Suwa University of Science,
Faculty of Engineering

Photovoltaic power generation system /Wind-power generation / Micro grid

Yasuyuki
Watanabe

Visiting
Professor

Suwa University of Science,
Faculty of Engineering

Molecular electronics & Bioelectronics /Photosynthetic engineering

Sho
Shirakata

Visiting
Professor

Ehime University

Semiconductor material engineering /Thin film photovoltaic cell, CIGS solar cell

SatoshiOhnishiVisiting
Researcher

National Institute for Environmental
Studies

Energy economics /Low carbon city management

Ayaka
Kanai

Visiting
Researcher

Nagaoka University of Technology

Thin ﬁlm photovoltaic cell /Optical Properties of Semiconductor

University of Tsukuba

Smart grid /Energy storage system management /PV generation forecasting

Daisuke
Kodaira14

Job title

MutsumiSugiyama

Visiting
Researcher

Tokyo University of Science

Optical transmittance ofthe transparent solar cell (%)

Name

Wavelength (nm)Transparent solar cells fabricated on
bio-derived transparent film substrates

Figs.

Solar matching (Co-developing technology
both photovoltaics and photosynthesis)

Research theme of Renewable Energy Science & Technology Research DivisionFunctional Materials
Established: April, 2021

gunji@rs.tus.ac.jp

Director
Professor,
Department of Pure and Applied
Chemistry,
Faculty of Science and Technology

Research Group for Advanced
Energy Conversion

Takahiro Gunji
Dr. Eng.

Objectives

This research aims at the development of novel “Only at TUS” energy systems
based on SDGs by establishing elemental know-how of the systematic materialto-system research.

Future Development Goals

Practical use of secondary cells and fuel cell systems, building of efficient
thermoelectric conversion systems, and the development of new light-reactive
materials.

An efficient, new energy system based on Sustainable
Development Goals (SDGs) is needed. In this group,
specialists in chemistry, mechanical engineering,
electronic engineering, and system engineering cometogether to develop and test a new, efficient system
for the generation, storage, and utilization of clean
energy by “Only at TUS”.

The development of a system for the generation, transformation, storage,
and utilization of energy by “Only at TUS”
The development and use of highly efficient energy systems are a matter ofurgency, because the exhaustion of petroleum resources and the resultant
economic instability are a call to action. The problem is conspicuous in ourcountry since it depends heavily on the import of petroleum. Studies arebeing carried out in the Division of Ecosystem Research and the Advanced
EC Device Research Division, on the development and testing of anelectrochemistry device for commercialization purposes.
The United Nations has set 17 targets as global SDGs, and these targets
are indispensable for future technical development. The following two relate

to our research group:
SDG 7: “Ensure access to affordable, reliable, sustainable, and modern energy
for all.”
SDG 12: “Ensure sustainable consumption and production patterns.”
In our research group, we will study the development and environmentfriendly use of new energy, following a product of the Advanced EC Device
Research Division, on electrochemical devices, hydrogen energy, heat energy,
and light energy.
Our research group consists of two teams: the research team for energy
transformation and the research team for energy storage. The research teamfor energy transformation takes charge of the development of technology
and materials for the generation and transformation of energy. The researchteam for energy storage takes charge of the development of technology andmaterials on the storage and utilization of energy. Both teams cooperatemutually with the aim of building a system for the generation, transformation,
storage, and utilization of energy. When an advanced energy device iscreated, its development is accelerated by cooperation between groupmembers beyond the limit of their specialty and research fields, to overcome
current problems and improve the fundamental knowledge level amonggroup members, furthering collaboration.
Based on “Only at TUS”, a researcher on the front line participating in thisresearch should be able to accumulate information and technological knowhow from scholars in the various fields and achieve high technicaldevelopment and originality.
A characteristic feature of our research group is the inclusion of the“Sustainable Energy Systems and Materials”course from the Graduate
School of Science and Technology curriculum. The participation of bothstudents and teachers is indispensable for the development of new materials
and systems. We plan to hand-down technology and knowledge fromgeneration to generation through research proceeds of students who carry
the science and technology of the next generation, and we plan for an
aggressive exchange between students and teachers in order to achieve thegoal of this research group early.

Research on energy conversion
Based on outcomes from the Division of Ecosystem Research and theAdvanced EC Device Research Division, the development of highly efficient,environment-friendly organic synthetic processes, and highly sensitive andfunctional light-reactive polymers are advancing. One of the aims of thisresearch group is the development of new catalytic reactions for the highly
selective reduction of carbonyl groups to methylene groups, to be used inapplications for organic compounds made up of elements other than oxygen.
Another objective of this group is the development of a polymer that
responds to multiple forms of energy, by designing a polymer that reacts
stepwise to light and heat. In addition, high-speed material screening will be
carried out using a combinatorial experimental method.
The generation and utilization of bio hydrogen will be proposed in relation
to SDG 12, based on life-cycle assessment (LCA). A system consisting of thegeneration of hydrogen from waste wood, its purification, storage, and use in
the generation of electricity through fuel cells, as well as in charge storage incapacitors will be built and evaluated based on LCA.
We will manufacture a printable wearable biofuel cell with paper andtransfer sheet. For example, a fuel cell that uses organic material in urine asfuel can be used for urine detection (Elderly care, health maintenance). By
using lactic acid in sweat as fuel, one can monitor the health of athletes. In
order to make the wearable device, we prepare mesoporous carbon
materials suitable for use as enzymes, and then develop a printable paper
device using the carbon as the electrodes.
In the development of the polymer electrolyte fuel cell, we synthesize ametal-complex-supported conductive diamond as the electrode catalyst anddevelop a novel silicon-based polymer as the electrolyte.

Research on energy storage
We aim to prepare high-capacity electrodes with structures that are wellcontrolled at atomic-to-micro levels and perform high-throughput material
screening, and device-oriented electrochemical and structural analyses. For
optimization of nano and micro structures of the electrodes, we will prepare
the powder using liquid-phase synthetic methods like solvothermal synthesis,
and then perform a surface coating on the pristine powder.
Atomic configurations of the materials will be simulated computationallyfor theoretical screening. In addition, we will investigate degradation
mechanisms of the batteries under various operation conditions, by means of
selected electrochemical techniques such as in-situ analyses of the atomic
and electronic structures using neutron and synchrotron X-ray sources andin-situ electrochemical impedance spectroscopy (EIS) by cooperating withenergy conversion group. This strategy enables us to produce a customized
and appropriate device design based on a working condition and a purposeof use.

Tokyo University of Science

15

Structural Materials
Established: April 2023

rmatsuza@rs.tus.ac.jp

Director
Professor
Department of Mechanical andAerospace Engineering,
Faculty of Science and Technology

Division of Composite
Materials Engineering

Ryosuke Matsuzaki
Doctor of Engineering

Objectives

E xper t s in various specialized fields, such as molding process, frac turemechanics, material science, and numerical simulation, collaborate to achieve
rapid technological development, with a focus on composite materials.

Future Development Goals

The division aims to be a center of research and development where theresults of basic research at the university are used as seeds to promote thedevelopment of applications in collaboration with industry.

The division is equipped with an advanced experimental
and analytical environment with faculty members
who are capable of advancing research centered oncomposite materials in a cross-sectional manner. We
also actively promote collaboration with industry,
government, and academia outside the university. If
you are interested in working with us, please feel free
to contact the head of the division.

We conduct research on a wide range of lightweight andhigh-strength composite materials, such as CFRP,
from the fundamentals to applications.
The Division of Composite Materials Engineering promotes research oncomposite materials with members who have extensive knowledge ofmaterials and structures. Composite materials have been mainly used in theaerospace field, but their adoption in the automotive industry has been
increasing in recent years, and their application to flying mobility is expected
to expand in the future (Figure 1). In order to utilize composite materials inthese new industrial fields, new design, evaluation, and molding methods
specific to CFRP are required. In this division, research is being conductedwith a particular focus on simulation technology and new forming methods.

As a new forming method, we are focusing on 3D printing of composite
materials (Figure 2). Conventional composite molding relies on the knowhow of skilled craftsmen and molds, and as a result, it is difficult to produce
a wide variety of products. On the other hand, general thermoplastic resinlaminated 3D printers have low mechanical properties of resin, making it
difficult to fabricate aerospace and automotive product-level structures.
However, recent progress in research on carbon fiber composite 3D printers
has solved these problems, and high-strength 3D modeling for automotive
and aerospace applications is now possible. In this division, research is being

Figure 1

Figure 2

Simulation technology ranges from material simulation at the atomic andmolecular level to fracture analysis at the structural level, and is studied inparallel with experimental verification. With the recent improvements incomputer performance, numerical analysis has become an important tool,
and we are benefiting from it.

16

 e expect personal flight mobility to become commonplace with theWdevelopment of composite materials engineering.

Tokyo University of Science

conducted on new optimal design methods applicable to carbon fiber
composite 3D printers, understanding the mechanism of molding by 3D
printing, and functionalization.
The division emphasizes industry-academia collaboration and serves as apartner for commissioned and joint research to meet the needs of industry.
We also focus on training engineers in composite materials. Our goal is tocreate synergies between the university and industry by producing a large
number of ready-to-work engineers who have acquired skills throughresearch. Our research division is characterized by education and research
activities based on strong collaboration between industry and academia.

Honeycomb structure molded by composite 3D printerStructural Materials
Established: April 2023

hiroshi@kobalab.com

Director
Professor
Department of MechanicalEngineering
Faculty of Engineering

Division of Implementation ofsustainable technology in society

Hiroshi Kobayashi
Ph.D

Objectives

The objective is to provide concrete solutions to realize a sustainable society bycreating new products which create new value.

Future Development Goals

To apply to NEDO and then obtain a large budget, to launch 1 new product/year,
to establish 1 venture/year, and to apply for 3 patents/year.

T h e t r u e l o n gin g o f e n gin e e r in g is to “ m a ke
something useful.” The social implementation ofuniversity-originated products mainly consists ofpublishing findings in papers and commenting onthem as academics. Whereas, in engineering, I thinkthat we should implement it as a real object and evensee how it’s used and useful. This division aims to bea role model for the social implementation.

Commercializing university-originated medical, welfare, and life support technologies
and energy ones that will realize a sustainable society.
First goal is social implementation
With a strong awareness of practicality and realization, this division aims
not only to produce papers but also to commercialize technologies thatcreate new value and open up new markets.
Therefore, as shown in the table below, we will combine the elemental
technologies possessed by the contributors, actively collaborate withexternal organizations (participants from external organizations areunderlined), and conduct collaborative research and development with anawareness of specific applications as an exit. is performed.
At the moment, there are only a few external organizations, but we will ask
them to participate as needed according to the progress and strengthen
cooperation beyond formality.
In addition, we will commercialize products and start ventures, and actively
promote social development of new technologies originating fromuniversities.
Compared to IT and materials/devices that spread rapidly around theworld, the creation of “products” as “things”, especially as integrated systemsof technologies that are directly related to our daily lives, has high risks andextremely poor cost performance.
For this reason, commercialization at universities tends to be generally
avoided, but since universities are public institutions of society, we willpropose new solutions to society in the form of “real things.”

Members and R&D content
Table 1 shows the specialized classifications of the members and thespecific items of applications that combine them.

This field is mainly classified into (1) motion analysis/sensing (images/
measurement and analysis in the table), (2) motion assistance/creation
devices (mechanisms/devices and control in the table), (3) vehicles, and (4)field verification/evaluation.
(1) are Kobayashi, Hashimoto, Takemura, Iida, Arai, Hobara, Hayakawa,Kasai, Ushijima, Huang, and Yoshida; (2) are Wada, Kobayashi, Hashimoto,Takemura, Iida, and Hobara; Matsumoto and Kasai each specialize.
For example, (1) A. Precise walking motion analysis device and B.
Swallowing sensor, (2) C. Assist device and prosthetic arm/leg, and (3) D.
Table1 The specialized classifications of the members and the specific items of applications
Application

Technology
Vehicle・Car

Medical andWelfareLivelihood
SupportAgriculture·Rehabilitation·Diagnosis·E xamination·Welfare Vehicle·M otion Assist·M otion Assist·M otion Assist·M onitoring·Automatic·Automatic Driving Cultivation/·Sports
Harvest·Genetically
Modified

Wada, Kurusu

Hayashi, Wada

Kobayashi, Iida,
Arai

Infrastructure・Production・Industry·M otion Assist·Digital
Fabrication·Laboratory
Automation·Recycle

Resource・
Energy·Binary Power
Generation

Arai

Kobayashi,
Hashimoto,Takemura, Iida,
Mechanism・Wada, Kurusu,
DeviceMatsumoto S.

Kobayashi,
Kobayashi,
Hashimoto,Takemura, Iida,
Takemura, Iida, Arai, Hobara
Matsumoto K.,
Wada, Nagano,
Hobara, Kurusu,
Matsumoto S.

Kobayashi,
Hashimoto, Arai

Kobayashi

Kobayashi,
Hashimoto,
Visual/Signal Takemura, Iida,
Processing・Measurement Arai, Hobara,
Hayakawa

Hashimoto,Takemura, Iida,
Takemura,
Arai, Hobara
Hayashi, Arai,
Matsumoto K.,
Hobara, Tabata,Miyashita

Takemura, Iida,
Arai, Hobara

Arai

Ushijima, Arai

Kobayashi,
Takemura,
Ushijima, Iida,
Wada

Kobayashi,
Hashimoto,Takemura,
Hayashi,Matsumoto K.,
Wada, Nagano

Iida, Arai

Analysis・Control

Hashimoto,
Yoshida,Ushijima, Iida,
Arai

Robotics・
Humanoid

Yoshida, Iida,
Arai

Hashimoto,
YoshidaIida, Arai

Yoshida, Arai,
Huang

Highly intuitive operation interface and omnidirectional mobile device. We
will create various deliverables by consolidating each knowledge.
The details are described below.
Kobayashi, Takemura, and Hobara will lead the development of a sensor
that extracts the three-dimensional displacement of the body during walking
and the rotation angle around three axes with high accuracy.
Yoshida, Miyashita, Tabata, and Huang link the movement of the wholebody with dynamic models and image analysis．
Accurate walking motion data of healthy and non-healthy subjects will be

accumulated, tools will be prepared to quantitatively indicate changes after
diagnosis and treatment, and practical application and commercialization
will be examined.
Kurusu and Matsumoto will acquire data at the clinical site.
In B, Hashimoto will lead the development of a swallowing sensor todetermine the presence or absence of aspiration in daily life and toencourage early rehabilitation intervention.
Currently, we are researching a unique sensing technology that cansimultaneously measure body sounds, muscle activity, and laryngeal
elevation during swallowing using a piezo film.
In addition, together with Kobayashi, we are developing a robot simulator
to clarify the swallowing mechanism, and we can make use of the knowledge
obtained.
In addition, Iida’s world-leading soft robotics technology will be used todevelop sensor devices with high biocompatibility and no discomfort whenworn.
Kurusu and Matsumoto conduct evaluation experiments in clinical settings
to evaluate the practicality of the medical and welfare equipment describedabove.
In addition, by providing feedback to each group, the development forpractical use can be advanced efficiently.
Kobayashi, Takemura, and Hobara have already put C into practical use.
Wada, Hayashi, and Nagano are the main members of D, and conduct
research and development on the design and control of mobile units andrelated systems that support the mobility of people with disabilities and theelderly.
It integrates elemental technologies such as electric motor control
technology that realizes the movement of mobile objects, comfortable andintuitive control interface, self-position recognition and route planningtechnology for mobile objects, remote control, automatic driving/navigation
technology, and so on.
Furthermore, by further expanding the application range of the originaltechnology “Active Caster” developed for the omnidirectional movement
system, we will consider practical application to wheelchairs and senior cars
using practical mobile robot technology.

Target results
In accordance with the progress of research and development, we will
periodically review specifications, prioritize them, roadmap forcommercialization, and new developments. We will operate with the goalsof 1 new product launch/year, 1 start-up venture/year, and 3 patentapplications/year.

Tokyo University of Science17

Bio and Pharmacy
Established: April 2023

shiina@rs.tus.ac.jp

Research Center for
Drug Discovery and Applied Sciences
Objectives

Our goals include the efficient production of pharmaceutical products from natural
and/or artificial compounds. In our research center, our team will collaborate withresearchers within the campus, as well as outside, who have made considerable
achievements in the field of molecular biology, thereby completely exploiting syntheticorganic technologies from which the representative research can derive its strength.

Future Development Goals

Recently, the discovery of new medicines originating from academia via industryuniversity collaboration from an industrial viewpoint has attracted a significant amount ofattention. Results obtained from such research provide a methodology for solving various
issues associated with the development of drugs derived from natural sources.

Director
Professor
Department of Division ofApplied Chemistry,
Faculty of Science Division Ⅰ

Isamu Shiina
Ph.D

In this project, novel biological research will be
conducted by completely exploiting organic synthesis
technology, referred to as the“total synthesis ofnaturally occurring products,”which has been scarcely
used so far for the discovery of new drugs. Synthetic
studies based on natural product-derived compounds
lead to the production of novel drugs with a uniquemechanistic MOA and pave the way for the treatment of
intractable diseases that have not been treated thus far.

Structure-Activity Relationship (SAR) and Mode of Action (MOA) Studies
Using New Compounds Developed at the Tokyo University of ScienceDevelopment of New Synthetic Methods for the
Effective Transformations in Organic Chemistry
A majority of the products that are used as medicines by humans comprisecarbon-based organic compounds, which are synthesized by combining
multiple chemical reactions. However, when it is crucial to perform several
reaction steps before achieving the synthesis of the desired compound,considerable time and effort are spent, as well as a considerable amount ofwaste is generated, thereby adding to the environmental burden.
Our synthetic team is conducting research on reaction methods that can
improve the synthetic yield of pharmaceutical products to the maximum.
Hence, in 2002, our team developed a new dehydration condensation agent,
namely 2-methyl-6-nitrobenzoic anhydride (MNBA), which can drasticallyenhance the production efficiency of antibiotics and anticancer drugs.
Dehydration condensation is a structural transformation where twohydrogen atoms and one oxygen atom are simultaneously removed fromorganic molecules, and two compounds are ligated using a reagent such asa dehydrating condensation agent. For decades, dehydration condensation
has been employed to construct the basic skeleton of pharmaceuticals.
However, as conventional methods require harsh reaction conditions,
including the use of an acid catalyst or high temperatures, issues related tothe destruction of reagents or compounds that serve as the raw materials
were noted.
With the establishment of the Shiina laboratory in 1999, compounds andreaction conditions for the invention of the fastest dehydration condensation
reaction in the world were thoroughly analyzed, which finally led to thedevelopment of MNBA.
After the establishment of this new technology, MNBA has been widelyused to synthesize new antibiotics, molecular target anticancer drugs, anddrugs for diabetes treatment, and more than 14,000 successful results havebeen reported worldwide (Please check YouTube using“YouTube MNBA
Shiina”as the keyword, Fig. 1).

raw materials. For example, some rare chemical compounds extracted fromsoil-borne bacteria exhibit anticancer properties. If these compounds can be
artificially synthesized, not only the stable production of medicines can beachieved but also the chemical structures that are optimum forpharmaceuticals, including the suppression of side effects, can be designed.
In the total synthesis research, MNBA is predominantly used for thesynthesis of organic compounds exhibiting anticancer properties.
Our team completed the total synthesis of M-COPA, which limits thefunction of the Golgi apparatus that is responsible for the transport of
intracellular proteins. Both domestic and international research groups haveattempted to apply this compound to cancer cells activated by the Golgi
apparatus to block transportation pathways and to suppress the growth ofcancer (Fig. 2). At the Shiina laboratory, our team has worked toward thedevelopment of a large-scale method to prepare M-COPA for use in animal
experiments.
Each reaction step was analyzed to ensure gram-scale production, or
higher, of M-COPA with seven consecutive stereogenic carbons. Our teamestablished largescale synthesis by effectively employing organic reactions,such as asymmetric aldol reaction, intramolecular Diels–Alder reaction, and
MNBA dehydration condensation reaction. Experiments to verify the effect on
cancer cells using M-COPA via total synthesis have been conducted, andeven the inhibition of proliferation of cancer, which has been thought to not
be cured using the current anticancer drugs, has been observed. In addition,other outstanding achievements have been consistently reported in articles.
The design of a synthetic method in the anticipation of the development up
to industrial use has played an important role in successfully achieving thisobjective.
In addition, these results have also been presented on YouTube.
These can be viewed on the YouTube handle“YouTube M-COPA Shiina”
or“YouTube Shiina Laboratory TUS.”

Fig. 1 Efficient Synthesis of Various Compounds Using MNBA
(The Shiina Research Group)(https://www.youtube.com/watch?v=Dw1ajJchujw)

A New Method for the Inhibition of Cancer Cells(Total Synthesis of Vesicle Protein Transport Blocker, M-COPA)
In this center, research on the“Development of New Reactions”and“Total
Synthesis of Natural Products”is interconnected as major research topics.
Total synthesis involves the artificial synthesis of natural-derived chemical
substances with complex molecular structures using a minimum amount of

18

Tokyo University of ScienceFig. 2 Proliferation Suppression Mechanism of Cancer Cells using M-COPA(Fig. 2 was created by Dr. Yuuki Obata who collaborates with Prof. Shiina:
PLOS ONE, 12(4), e0175514 (2017))

Bio and Pharmacy
Established: April, 2019

twada@rs.tus.ac.jp

Director
Professor,
Department of Pharmaceutical
Sciences

Division of Nucleic Acid
Drug Development

Takeshi Wada
Doctor of Science

Objectives

We aim to create nucleic acid drugs to treat unprecedented target diseases
through the synthesis of novel chemically-modified nucleic acids and theestablishment of DDS and formulation methods.

Future Development Goals

Our goal is to make a breakthrough in the field of nucleic acid drugs through thecollaboration of researchers within the university.

T h i s d i v i s i o n w a s e s t a b l i s h e d b y t h e c r o s sdepartmental team of in-house researchers working
on the nucleic acid or other related research fields.
By succession of networks and joint researches
created through the activity of the TR center, we aim
to develop innovative nucleic acid drugs from TUS.

Development of nucleic acid-based drugs that are expected to be a next-generation drugHistory of This Division
The TR (Translational Research) center, which was the former organizationof this division and lasted until 2018, got notable results in the field of
nucleic acid drug. Also, nucleic acid-based drugs have recently attracted
much attention as a next generation type drug. There are a plenty of
researchers who work on nucleic acids at TUS, and the most of them took
part the activity of TR center. Then,“round-table conference on nucleic aciddrugs and DDS”was established in 2017 (representative: Prof. Makiya
Nishikawa), and we have active discussions on nucleic acid drugs. Under
these circumstances, the Division of Nucleic Acid Drug Development wasestablished as a subsequent organization of TR center in April 2019.

Research Objectives
The development of nucleic acid drugs requires a knowledge from wide
range of research field. There are many prominent researchers who work on
nucleic acid or related research at TUS, thus innovative and unique results
are highly anticipated through their collaborations. In this division, one of our
mission is the development of novel nucleic acid derivatives which
overwhelm conventional ones in the viewpoint of efficacy, stability andsafety. Also, we aim at establishing the cationic molecules and formulation
technology which stabilize and improve pharmacokinetics of nucleic aciddrugs. We chose immune system, metabolic system related diseases andcancer as targets. As just described, the development of original nucleic aciddrugs targeting unique diseases are highly expected by gathering of in-housecompetent researchers in this division.

Figure 1

Oligonucleotides as therapeutic agents

Members
In-house Members
Faculty of Pharmaceutical Sciences
Takeshi Wada (Organic chemistry)
Makiya Nishikawa (Drug delivery system)
Takehisa Hanawa (Medicinal formulation)
Yoshikazu Higami (Molecular pathology and metabolic diseases)
Kazunori Akimoto (Molecular pathology)
Chikamasa Yamashita (Physical pharmacy)
Yosuke Harada (Immunology)
Faculty of Science
Satoru Miyazaki (Bioinformatics)
Hidetaka Torigoe (Biophysical chemistry)
Hidenori Otsuka (Polymer chemistry)
Faculty of Advanced Engineering
Chiharu Nishiyama (Immunology, allergy and molecular biology)
Suguru Yoshida (Organic synthesis)

Research Institute of Biomedical Sciences
Ryo Goitsuka (Developmental immunology)
Masayuki Sakurai (RNA editing)
The Division of Nucleic Acid Drug Development
Faculty of
Pharmaceutical
Sciences

Takeshi Wada

Organic Chemistry

Yoshikazu Higami
Metabolic Diseases

Satoru Miyazaki

Drug Delivery System

Faculty of Science

Bioinformatics

Physical pharmacy

Yosuke Harada
Immunology

Hidetaka Torigoe

Kazunori Akimoto

Chikamasa Yamashita

Biophysical Chemistry

Oncology

Takehisa Hanawa

Hedenori Otsuka

Medicinal Formulation

Ryo Goitsuka

Developmental Immunology

Research Instituteof Biomedical
Sciences

Makiya Nishikawa

Masayuki Sakurai

Faculty of
AdvancedEngineering

RNA Editing

Polymer Chemistry

Chiharu Nishiyama
Immunology

Suguru Yoshida
Organic synthesis

Figure 2 urrent Situation of Nucleic Acid Drugs and C
Our Research Topics
Nucleic acid-based drugs are anticipated to be an epoch-making remedy
for the treatment of intractable hereditary diseases. The global market sizeof nucleic acid-based drugs is predicted to expand to 19 billion dollars in
2030 from 2 billion dollars in 2018, according to the estimation of Seed
Planning Inc., a marketing research and consulting enterprise. Althoughmuch efforts have been devoted to the research of nucleic acid-based drugs,
only 17 drugs have been approved so far. There are a lot of challenges toovercome for the development of potent nucleic acid drugs, and a breakthrough is required for the further progress of this area. To address this issue,
we are dealing with following topics;
1. D evelopment of an efficient method to synthesize boranophosphateoligonucleotides which is anticipated as an alternative candidate ofphosphorothioate
2. E stablishment of a scalable synthetic method of artificial cationicoligosaccharides and peptides that bind to and stabilize nucleic acids.
3. Construction of a highly target selective drug delivery system through theelucidation of interaction between nano-structured nucleic acid and cells
4. Development of antisense drugs that target such as wound and bladdercancer remedy
5. Development of a novel formulation method of nucleic acid drug
6. Research on the control of aging, aging related diseases and metabolic
abnormalities by nucleic acid drugs
7. Development of nucleic acid drugs which regulate autoimmune response
and rejection reaction during an organ transplantation
8. Development of effective breast cancer drugs using novel artificial cationicmolecules and siRNAs
9. Establishment of investigation technology via bioinformatics and AI todetermine the sequence of a mRNA that codes disease-related protein

Tokyo University of Science19

Bio and Pharmacy
Established: April, 2019ikawa@rs.tus.ac.jp

Director
Professor,
Division of Immunology
and Allergy

Division of Synthetic Biology

Tomokatsu Ikawa
Ph.D.

Objectives

Using informatics analysis and modern biotechnology such as DNA synthesis,
cell fusion, microinjection and microscopic laser technolog y, we create
genetically transplanted cells.

Future Development Goals

Emphasis on ethical, legal and social impacts, we aim to establish genometransplantation technology with sufficient safety measures.

We will promote our synthetic biology projects thatcreate cells with our frontier spirits. This researchdivision can become a platform for joint research,
information sharing and technology exchange withsynthetic biology researchers.

We create genetically transplanted cells, which will contribute to useful substanceproduction and medical technology.
Synthetic biology is the study to elucidate the biological principle throughartificial cells with DNA synthesis. Pet animals such as dogs and cats,horticultural crops such as orchids, livestock such as mules and chickens,and multiple species of agricultural products such as wheat and fruits are
hybrids by crosses of related species. Since ancient times, we have createdand used such genomic hybrid organisms. Current technological innovations
have also enabled crosses and transfer of genomes other than closely
related species. In order to create a frontier area from the modern
biotechnology, we will promote departmental research. Our research is
conducted with strict awareness of ethical, legal and social issues. With aview to the development of useful substance production technology andmedical technology in the future, we will promote the following threeresearch subjects with the aim of establishing a genome transfer technology
with sufficient safety measures.

Strategy 1: Plant genome transplantation
There are many modules in the plant genome that are not found in animal
genome, such as photosynthetic modules, pigment modules, and metabolic
pathway modules that produce medicine materials. By transplanting theseplant modules into the animal genome, we aim to impart new functions toanimal cells. We call artificially photosynthetic animal cells“planimal cells”(Figure 1).

Figure 1

20

Tokyo University of Science

Strategy 2: Genome transfer beyond the species barrier
Even close relatives, there is a “species barrier” in genome crossing
between organisms. Therefore, we aim to create ascomycete hybrid cells
that enable useful substance production by genome engineering and cellfusion.
Strategy 3: Cell creation leading to regenerative medicine
Methods to control cell proliferation and cell metabolism are needed topromote the production of spheroids and organoids. We aim to develop

technologies that can be safely applied to medical technology byincorporating a regulatory system with epigenetic and optogenetic
techniques.
Through this department, the fields of biology divided into microbiology,
botany, zoology and medical science can be fused to make it possible toelucidate the basic principles of life.

Creation of artificially photosynthetic animal cells“planimal cells”

Bio and Pharmacy
Established: April, 2020

garimura@rs.tus.ac.jp

Director
Professor
Department of Biological Scienceand Technology,
Faculty of Advanced Engineering

Division of Biological
Environment Innovation

Gen-ichiro Arimura
Ph.D.

Objectives

We explore the mechanisms by which life adapts and diversifies, and evolution
occurs in a rapidly changing habitat environment. Our aim is also to develop
technological seeds that contribute to our food and health quality.

Future Development Goals

We will create a new revolutionary academic field that has never existed byfusing individually developed research areas such as environmental biology andecology.

With the theme of “environment,” we will elucidate
the environmental adaptabilit y and molecul ar
evolution mechanisms of various species, such as
plants, mammals, reptiles, amphibians, fish, insects,
and fungi species. We will explore applications ofnovel discoveries to aid the preservation of natural
ecosystems and biological diversity.

Bioenvironmental research with the aim of creation of synergy between academic fields
and technological seeds in an environmentally changing society.
Summary
Academic experts in the fields of environmental adaptation, biologicalinteractions, molecular evolution, co-evolution, and ecology of livingorganisms have formed three subgroups“the section of environmental
adaptation”,“the section of molecular evolution” , and the“section of nature
symbiosis”. In order to create an academic research field that breaks throughthe classical concepts and barriers of environmental biology, evolutionary
science, and ecology, we produce new technological seeds that willcontribute to protecting our lives in a global environment that is always
changing.

<Section of Molecular Evolution>
We analyze the mechanisms of genomic evolution and biology’s central
dogma that enable adaptation and diversification of life from the viewpointof evolution, which has been overlooked in the past. We also aim to develop
new life system technology beyond conventional conceptions.
• Elucidation and utilization of minimum components and the mechanism of
biological protein synthesis system of life on Earth• Development of new life system technology based on RNA technology
Members: Koji Tamura, Toshiki Furuya, Mitsunori Shiroishi, Masayuki Sakurai,
Takashi Nakajima, Kazunori Okada (Univ. of Tokyo), Akiko Soma (Chiba Univ.)<Section of Environmental Adaption>
We explore to find the mechanisms underlying biological sensing ofenvironmental stress, and develop new technologies including environmental
stress-adaptive cultivation systems.
• Elucidation of the mechanisms underlying the evolution and diversity oflives• Development of significant plant lines adapted for environmental stress
tolerance and biologial interaction, leading to the creation of next-generation
organic cultivation systems using immunostimulants and companion plantsthat contribute to reduced pesticide use.
Members: Gen-ichiro Arimura, Kazuyuki Kuchitsu, Ryuichi Nishihama, Hisataka
Ohta, Fuminori Takahashi, Takuya Uemura, Kenji Hashimoto, Takuya Sakamoto(Kanagawa Univ.), Sachihiro Matsunaga (Univ. of Tokyo)

Figure 2<Section of Nature Symbiosis>
We advance scientific knowledge that contributes to the conservation of
ecosystems and biodiversity, and develop technologies for assessing risks ofchemical substances to living things and for managing and improving the air,water, and soil environment.
• Elucidation of environmental factors and mechanisms that affect future
biological production• D evelopment of analytical methods for atmospheric molecules andenvironmental chemicals, and of methods for assessing the effects on livingorganisms
Members: Shinichi Miyagawa, Shinichi Satake, Yoshitsugu Akiyama, Yutaka Sumino,
Takuya Saito (NIEFS)

Figure 1

Figure 3
Tokyo University of Science21

Bio and Pharmacy
Established: April, 2021

makiya@rs.tus.ac.jp

Director
Professor
Department of Pharmacy
Faculty of Pharmaceutical Sciences

Development of superior cell and
DDS for regenerative medicine

Objectives

To develop “superior cells” and DDS that can precisely control the function andin vivo fate of the cells for accelerating regenerative medicine.

Future Development Goals

To create a novel and unique research field focusing on “superior cells” bycollaboration of researchers with a variety of expertise.

Makiya Nishikawa
Ph.D.

Cell-based therapy and regenerative medicine canbe greatly accelerated by applying the concept ofdrug delivery system (DDS), i.e., drug delivery at theright time, at the right site of action, and in the rightamount, to cells that are administered to patients fordisease treatment. This division aims at developing“superior cells” whose functions are ex tremely
upregulated and DDS that improves their functions.

Development of superior cells and DDS for accelerating regenerative medicine
History and Background of This DivisionThis division has a root in the DDS Research Division established in the
Research Institutes for Science and Technology, Tokyo University of Sciencein 2003. In“Fusion of Regenerative Medicine with DDS Division”started from2015, researchers headed by Professor Kimiko Makino have conductedcollaborative researches focusing on regenerative medicine and thedevelopment of DDS for intractable diseases. To continue these activities, apredecessor round-table conference on Superior Cells and DDS Developmentfor Regenerative Medicine was founded on 2020, which has been reestablished as a division in April 2021.

Figure 1 summarizes the members and roles of each group. This divisiondevelops superior cells and DDS regenerative medicine by constructing
organic interrelationships among the members of the division in pursuit of a
new-stage collaboration.

Research Purposes and Goals of This Division
Under the overall goal of accelerating cell-based therapy and regenerative
medicine, this division is focusing on (1) the development of“superior cells”
by functionalizing the cells administered to patients for therapeutic purposes,and (2) the development of DDS that can precisely manipulate the in vivo
distribution of cells and other functional molecules. The research purposesalso include the development of therapeutic modalities against respiratory,
brain, immune, cancer, and bone diseases.

Members and Their Roles in This Division
The four groups below cooperate with one another to accelerate thegroup research.
(1) Superior cell/DDS development group
This group designs and constructs superior cells, and develops DDS aiming
at controlling the function and in vivo distribution of cells and other functional
bioactive molecules. A goal is to develop“superior cells”that super-exceed
the existing cells in terms of cellular functions through (1) the addition ofnovel functions, (2) the development of multicellular spheroids/organoids,and (3) the use of exosomes and other extracellular vesicles. In addition,
various delivery systems are developed and applied to the superior cells andtheir usefulness is examined in animal models.
(2) Cell function regulation system development group
This group creates novel compounds that regulate cellular functions, andfunctional materials that can be used in cell-based therapy and regenerative
medicine. These compounds and materials are supplied to other groups forapplications and analysis. The data obtained using them are used for thedevelopment of more functional compounds/materials.
(3) Physical property control/analysis group
This group evaluates the physical properties of the items developed by thesuperior cell/DDS development group and the cell function regulation systemdevelopment group, including superior cells, delivery systems, and functional
compounds/materials. This group supports the optimization of these items
by data feedback to the corresponding groups.
(4) Cell/tissue regeneration group
This group investigates the mechanisms of the regeneration of the lung, boneand other tissues, and treat the diseases of these tissues/organs. Theinteraction of superior cells/DDS and the immune systems is also analyzed.

22Tokyo University of Science

Figure 1

Members and roles of each group.

Information and Societal
Established: April, 2004

kmatsu@rs.tus.ac.jp

Director
Professor,
Department of Global Fire Scienceand Technology,Graduate Schoolof Science and Technology

Center for Fire Scienceand Technology

Ken Matsuyama
Dr. Eng.

Objectives

To promote the development of fire science and fire safety engineering, as wellas the training of young researchers and specialist professionals.

Future Development Goals

To establish an education and research center at the highest level of the world,
to meet various social demands concerning fire safety, and to contribute tosociety.

Safety and security play pivotal roles in social development.
TUS has, as a core of the fire safety engineering community
both domestically and internationally, contributed to theiradvancement. In recent years, major cities in East Asia inparticular have been undergoing marked development at a
speed that no other Asian countries, including Japan, haveever experienced. We have a duty to mitigate this urgent
situation sufficiently and, at the same time, to develop
the innovative educational research system to prevent theoccurrence of such fire accidents.

Research on the safety technology to protect human life and property from fires,and research on the fire science to support it.
Fire science at TUS
In 1981, Tokyo University of Science established Department of Fire
Science and Technology in its Institute for Science and Technology. The aim
was to set up a research center that would promote research on the safety
technology to protect human life and property from fires, and research on
the fire science that supports the technology. This development was initiallystarted by the inauguration of a course on Architectural Fire Safety
Engineering when the Department of Architecture, TUS was founded some
50 years ago. In this way, TUS laid the foundations of research and education
on fire science ahead of the times, when such developments were unknownin other universities. These foundations have yielded a strong record ofaccomplishment of achievements since then, as amply illustrated in the factthat we have received two prestigious awards from the International
Association for Fire Safety Science, the highest authority body of its kind in
the world. The first of these was awarded for“Meritorious achievements inresearch contributing to the advancement of fire safety science”, and thesecond was for“Meritorious achievements in education producing numerous
researchers in fire science”. In the past, Japan has suffered many fires in large
buildings, which have claimed a large number of human lives. Members of
the Department of Fire Science and Technology, TUS have been involved inappraising the majority of these serious building fires since 1968.
In recognition of this record of accomplishment, the Department was
included in the 21st Century COE Program of the Ministry of Education,
Culture, Sports, Science and Technology (MEXT) in fiscal 2003, as a“Center ofAdvanced Fire Safety Science and Technology for Buildings”. It is currently
engaged in activities aimed at establishing itself as a research and education

center on fire science and fire safety engineering at the world’s highest level.
Other aims are to promote the advancement of fire safety engineering and thetraining of young researchers and specialist professionals. We will continue
our efforts in offering innovative education and research to protect human lives
and properties from fires. Following the 21st Century COE Program, whichconcluded in 2007, the Global COE Program 2008, which would conclude in2012, further adopted the“Center for Education and Research on Advanced
Fire Safety Science and Technology in East Asia”. Now, the Center restarted asa five-year project after having been selected as a 2013 recipient of the Private
University Strategic Research Formation Assistance Grant from the MEXT. “Fire
Safety Information Center in Asia based on Sharing Expertise-New Fire Safety
in Information Society” was started. Fire Safety Information in Asia as a
research base that focuses on building a network of networks, and works
together to reduce fire risk in Asian cities, we have realized the global
development of science, which is an issue for the 21st century.
Since April 2018, it has been playing a role as permanent organization of“Fire Science Research Center”, as a center for fire science and fire safetyengineering that represents East Asia.

Fire Research and Test Laboratory
Taking the opportunity of being adopted as the 21st Century COE Program,
this laboratory was built in March 2005. It is one of the largest and mostfunctional laboratories in the world meant solely for fire science. Built at Noda
campus, it has a building area of 1,500 m2, and gross floor area of 1,900 m2, anda height of 20 m (Photo1). Members of the Center constructed a basic plan anddid the designing utilizing their wealth of experiences, so that the laboratory
would enable us to promote world-leading researches on fire sciences.
In March 2006, a large-scale fire furnace was added. Other large-scale
experimental facilities to be included in the laboratory are composite
furnace, fire resistance assessment machines for exterior wall materials, andcombustion performance testing facilities, which are needed internationally,
to contribute to the advancement of innovative researches.

Graduate School of Global Fire Science and Technology
The Master’s Course in Fire Science & Technology at the Tokyo University of
Science’s Graduate School of Global Fire Science & Technology was establishedin April 2010 is the first postgraduate fire science course in Asia, and is aimed atthose employed in the area of fire science and safety (such as the construction,
firefighting, and non-life insurance industries) as well as students from Japan andoverseas who want to become fire safety technicians and fire officers.
The graduate school represents one aspect of the MEXTs Center of
Excellence (COE) program,“Center for Education and Research on Advanced
Fire Safety Science & Technology in East Asia”, being promoted by the Center
for Fire Science and Technology, and aims to establish Asia’s first definitive
fire science education facility. The school to familiarize students with basic
theory in a practical setting uses the Fire Research Test Laboratory.
In addition to the Master’s Course, students also have the opportunity tocontinue their studies, such as Doctoral Course in Fire Science & Technology
established in April 2012. The Department of Global Fire Science andTechnology is scheduled to be set up in April 2018 under the Graduate
School of Science and Technology by reorganization of the Graduate School.

Designated Performance Evaluation
In order to improve fire safety technology and improve reliability at the Fire
Science Research Center, the Building Standard Law has been applied to theconstruction method of buildings as a designated performance evaluation bodydesignated by a designated performance evaluation body of the Ministry ofLand, Infrastructure and Transport. Carry out performance evaluations required
to obtain Minister of Land, Infrastructure, Transport and Tourism approval.
Performance evaluation is conducted by an evaluator who has expert
knowledge of the field of performance evaluation based on the businessmethod approved by the Minister of Land, Infrastructure, Transport and Tourism.
Current Conditions

Mission

COE Outcomes
MEXT-Supported Program for
the Strategic Research
Foundation at Private Universities
Outcomes

Increasing Fire
Risk in Major
East Asian Cities

Education andResearch Demand
In Each Country

Fig. 1

Department of Global Fire
Science and Technology
Education

Respond to
the Need toTrain Specialist

Practical Training Programs
Programs for Nurturing
Researchers

Center for Fire Science
And Technology
Research
Advanced Fire ScienceCentral Core for Fire
Safety Technology
Integration of
Knowledge
In East Asia
Technological
Development for Fire
Disaster Prevention
in East Asia

Practical Performance
Evaluation and Design
For Fire Safety

Perspective of the Center for Fire Science and Technology
Photo 1

Fire Research and Test Laboratory

Fig. 2 Home‌
Page
「Center for Fire Science and Technology」
https://gcoe.tus-fire.com/
Tokyo University of Science23

Information and Societal
Established: April, 2021

ssi@rs.tus.ac.jp

Director
Professor,
Department of ElectricalEngineering,
Faculty of Science and Technology

Research Center forSpace System Innovation[ SSI ]Objectives
Objectives
Future Development Goals
Future Development Goals

Shinichi Kimura
Ph.D.

To develop a virtuous cycle between earth and space research and solve various●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
problems
common to both.
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
Through technology transfer to collaborative private companies, SSI aims to●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
enhancestate-of-the-art technologies that can improve life on earth and are●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
usablein space.

The goal of the center is to become an innovationdriven hub for outer space and ear th researchthrough collabor ation with various entities .
T hese coll ab o r ations will allow innov ation by
fostering excellent human resources. Researchers,
businesspersons, and students can explore thefrontiers of space.

Living in space, bringing benefits to earth!
－Trial for Space-Terrestrial Dual Development on Space Living and Spacecraft－
Background of SSI Establishment
In recent years, space research has gained considerable attention. Space
systems are multidisciplinary, and in addition to aerospace engineering,
require expertise of various domains. As exemplified by recycling-based livingin the closed environment of space, technologies required for humanity toreach into space are closely related to solving various earth-related
problems, such as sustainable development and a recycling society.

Research Organization of SSI▪ Education Unit
- Education based on“real”technology and experience that can be usedin space Utilizing Tokyo University of Science research, such as flight missions,rocket launches, theoretical research in astrophysics, and astronomical
observations, for the purpose of education can be an incentive for bothresearchers and students. In addition to participating in numerous missions,
we will cooperate with domestic and international space development
organizations, space venture companies, and space development companies
and actively use the results for education.
▪ Photocatalysis International Unit
- Solving resource and environmental problems by using photocatalysis Photocatalysts, such as titanium dioxide, can effectively decompose
organic pollutants and exhibit antibacterial and disinfecting properties
because of their strong oxidative decomposition. Considerable research is
being conducted on artificial photosynthesis using photocatalysts (hydrogenproduction by water decomposition and generation of valuable substancesby carbon dioxide reduction). By advancing these studies, we can address
existing issues, such as environmental purification and energy production, on
earth and implement solutions in space.

About the Center
By pooling research and education activities related to space development
and space environment utilization at Tokyo University of Science, theresearch center can be used for comprehensive analyses of various
technological challenges, including research related to space travel.
The aim is to develop a creation hub in which cross-disciplinary technologies
and human resources can be pooled to form a virtuous cycle to solve
problems common to both space and earth.
・B y utilizing photocatalytic technology, which is the specialty of ouruniversity, we aim to develop life-support technologies in space and realizea safe and comfortable living environment on earth.
・We will demonstrate suborbital spaceplanes under development, anddevelop a new“space”market in partnership with the industry.
・The Research Center for Space Colony, which has been researching anddeveloping space-stay technologies, will shift its focus to “dualdevelopment on earth and in space, and the development of spacevehicles to bridge the two,”to achieve strategic development.
・W e will provide a place for education based on space research
opportunities, secure and foster PhD students and young researchers, anddevelop an environment where they can experience“real”research.

24

Tokyo University of Science▪ Space Colony Unit
-Advancement of space-stay technologies and promotion of their use,with a focus on space habituation We will conduct cross-disciplinary research on various technologies related
to clothing, food, and housing that have not been directly related to space
so far, as well as infrastructure construction technologies, such as electric
power and telecommunications, in closed environments. In addition, we will
collaborate with companies and research institutes for the development of
space-stay technology to allow humans to stay in an extreme closed
environment for a long time. The results can be applied in case of common
problems such as disasters or food scarcity on earth.
▪ Spaceplane Unit
- Development of spaceplanes that can facilitate easy space travel The Spaceplane Unit is focused on the integration of technologies including
system optimization technology, fault-tolerant systems, LOX/LNG engine
operation, autonomous navigation technology, composite airframes andpropellant tanks, and legalization of commercial space transportation. This
integration is necessary to allow travel to and from space using spaceplanes
in a manner similar to airplanes under the motto“Space is for everyone.”

Information and Societal
Established: August, 2023

nihei@rs.tus.ac.jp

Director
Professor
Department of Civil Engineering
Faculty of Science and Technology

Research Center for Multi-Hazard
Urban Disaster Prevention
Objectives
Objectives
Future Development Goals
Future Development Goals

Yasuo Nihei
Ph.D.

Our mission is to develop and apply innovative urban disaster prevention studies
that target multi-hazards, with the ultimate goal of fostering a safe, sustainable
society that values diversity and ensures no one is left behind.
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●We
are dedicated to stimulating research exchanges both within and beyond●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
the university, focusing particularly on multi-hazard urban disaster prevention.
●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
N
otably, we aim to foster the ex pansion of connec tions among young●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●
researchersand students.

Even a single hazard - be it a natural disaster, alarge fire, or a novel infectious disease - can spelldisaster. However, when multiple hazards coincide,the situation escalates into a crisis threatening thesurvival of the nation. In response to this challenging
problem, we collaborate with researchers fromvarious hazard-related and data science fields. Would
you consider joining our quest to save as many lives
as possible?

Research center for multi-hazard urban disaster prevention
What is multi-hazard?
Cities, the epicenters of population density and valuable assets, represent
unique societal structures and living spaces teeming with skyscrapers andbustling with a vast network of transportation and information. The blend oforder and intensity has peaked within these urban landscapes. However,these complex systems are vulnerable to chain reactions of devastation in
the face of natural disasters, large fires, and the emergence of new infectious
diseases. Should an element of the system fail, it can trigger a cascadingcollapse of others, leading to widespread social unrest, medical emergencies,
and life-threatening situations.
Located in a region prone to frequent natural calamities, Japan presents
significant urban risks from a global perspective. Particularly, earthquakes,
tsunamis, floods, storm surges, strong winds, volcanic eruptions, and fires, as
exemplified by historical events, such as the Great Kanto Earthquake of1923, Great Hanshin-Awaji Earthquake of 1995, and Great East Japan
Earthquake of 2011, pose significant threats. The nation's future anticipates
further calamities such as the Tokyo Inland Earthquake, Nankai TroughEarthquake, and super typhoons. The impact becomes even more severe
when multiple hazards occur simultaneously within the same region, ascenario known as spatially chained multi-hazard. In such cases, the survivalof the nation is at stake. Therefore, we must leverage previous research oneach type of hazard, elevating it into an academic system that addresses
these time-space chained multi-hazards. Our goal is to develop acomprehensive approach that transcends various disciplines, including
science, engineering, life science, humanities, and social sciences. The
advancement of urban disaster prevention science is essential in thisendeavor.

Fig. 1

Direction of this research center

Fig. 2

Research system

Direction
At our center, our objective is to develop and apply innovative studies ontime-space-linked multi-hazard urban disaster prevention. Our goal is tocontribute towards building a safe, sustainable society that values diversity
and ensures no one is left behind (Fig. 1). Our university houses numerous
researchers specializing in disaster prevention across various hazards,
including earthquakes, fires, and floods, as well as experts in data science.
We intend to forge a new path in urban disaster prevention studies throughtwo collaborative cross-sections: the synergy between disaster prevention
researchers and the combined efforts of these researchers and data science
professionals.

Research system
This center is composed of approximately 10 faculty members hailing fromdiverse faculties and graduate schools within the university. The research
units include: (1) the Multi-Hazard Unit, led by Professor Ken Matsuyama
from the Department of Global Fire Science and Technology, Graduate
School of Science and Engineering; (2) the Disaster Prevention Informatics
Unit, led by Professor Takahiro Yamamoto from the Department of Physics,
Faculty of Science; and (3) the Regional Co-Creation Unit, led by Professor
Takumi Ito from the Department of Architecture, Faculty of Engineering.
Moving forward, the center will collaborate with external academic
institutions (such as universities and scholarly societies), administrative
bodies (including national and local governments, medical institutions),
national research institutes (specializing in various areas including civilengineering, architecture, disaster prevention, and materials and information
systems), and private sector entities (including sectors such ascommunication, electricity/gas, automotive, construction, IT, and media).

Tokyo University of Science25

Information and Societal
Established: April, 2014

o.taka@rs.tus.ac.jp

Research Division for Advanced
Disaster Prevention on Cities

Director
Professor
Department of architecture,
Faculty of engineering

Osamu Takahashi
Dr.Eng.

Objectives

Respond to the cityʼs complex environment and lives caused by the significant
development of technology, by bringing together wisdom for various fields ofarchitecture. Explore the Visions for Tokyo as a metropolis in the 21st century from theKagurazaka and Sotobori (outer moat) areas, where Tokyo University of Science locates.
How to prepare modern cities should against incoming unprecedented disasters

Future Development Goals

Building up theories for city planning with the sustainability and resilience against
disasters.Renewal of infrastructures in cities by merging various perspectives andknowledge of the architectural fields: materials, structures, planning, design, andhistory, into the primal purpose, disaster prevention.

This research division is composed of exper ts ofarchitecture, city planning and civil engineering.
Stuffs belong to Faculty of Engineering and to Facultyof Science and Engineering, and School of International
Fire Science. For many years, researchers in this divisioncontinue to develop regional researches, contributions
to local communities, and regional exchanges with thickaccumulation of their researches.
We aim to create result s to contribute the areal
development of Kagurazaka and Sotobori area where is
the home of Tokyo University of Science.

Based on the theme of “Disaster Prevention in Cities Built on Advanced Systems”, building
cities which enable recovery, maintenance and sustain their whole cultures and functions onthemselves, by interconnecting the research results of the three fields: city culture, city
performances and city planning.
Academics or Social Characteristics for the Division
The researchers and specialists belonging to this division consist of faculty
members from four faculties: the Faculty of Engineering, the Former Facultyof Engineering II, the Faculty of Science and Technology for Innovation, andthe International Graduate School of Fire Science and Technology.
They are conducting front-line research in their respective fields ofexpertise. In addition, they are certificated by major domestic academic
societies such as AIJ (Architectural Institute of Japan), CPIJ (The City Planning
Institute of Japan), and SAHJ (Society of Architectural Historians of Japan).
Our division collaborates for advanced research in various fields related tocity planning, including architecture and disaster prevention.
The Kagurazaka and its surrounding areas are unique in terms ofchronological context and city structure in the world’s city’s history, andresearch on these areas is likely to attract international attention.
In addition, there are high expectations from both sectors public(governmental organizations) and private (private commercial and non-profit
organizations) for proposing, reflecting, and presenting the results of ourresearch.
This is one of the unique characteristics of contribution to society by theuniversity and the division.

Areas Researching
Our principal research areas are Kagurazaka and its surrounding areas
including Sotobori (outer moat), which should be called the home of Tokyo
University of Science.
Researchers and specialists belonging for the division have long been
engaged in regional research, contribution, and exchange activities in theseareas, and have accumulated sufficient research experience.
We have created disaster prevention plan models and city plan models
based on the results obtained in the areas.
We will develop urban disaster prevention research by applying andextending these results to urban areas throughout Japan.

Fig. 1Historical Changes of Kagurazaka“Outside of Sotobori”, Lecture of Professor
Akihisa ITO, April 2014

‌Research field and partners

Fig. 2 “Sotobori-Kagurazaka‌
7 images”, CKARD_TUS, April 201426

Tbl. 1

Tokyo University of ScienceFig. 3 “Brought
Close between Town and Sotobori”Proposal to connect town and
Sotobori with a barrier-free deck, Sotobori Reconstruction Plan Symposium,
CKARD_TUS, May 2014

Information and Societal
Established: April, 2020seo@rs.tus.ac.jp

Director
Professor,
Department of Applied
Mathematics,
Faculty of Science

Statistical Science
Research Division

Takashi Seo
D.Sc.

Objectives

In this research division, the researchers interested in the underlying common
theory gather to improve the level of study on essential theories and methods.
Additionally, we aim to create new theories in the age of data science anddevelop new fields.

Future Development Goals

This research division contributes to the study of mathematical data science
with the aim of working closely with the Data Science Center, conducting joint
research with companies, and becoming a base for the international research on
statistical science.

Many professors involved in statistics are enrolled in
our university, across campuses and undergraduate
depar tment s . In this research division, these
professors from the field of statistical science
come together and actively interact with each otherto conduct a research which is unique to Tokyo
University of Science. In the future, we would like toestablish a“Statistical Science Research Center” and“AI and Data Science Theory Research Center”.

Development of mathematical and applied statistics and their fusion
Background and Purpose of the Research Department“Statistical science”is a field of study that uses the concept of probability
to provide optimality theory and statistical methods to estimate thecharacteristics of the population behind the data obtained. In the recent
years,“data science”, which is associated with big data, as well as artificial
intelligence (AI), has attracted significant attention. Furthermore, the core ofthese theories is“statistical science (statistical theory)”, which has gained
considerable prominence.
Accordingly, our university must build a research system that will lead not
only Japan but also the rest of the world in the domain of AI and data
science research. However, research in AI and data science is significantly
extensive. Tokyo University of Science has been planning to conduct researchin this field, intending to make the world proud. The university has many
faculty members who specialize in“statistics”, and these members arepresent across all its campuses. In particular, it is no exaggeration to say that
our university is the only one in Japan with a huge number of researchersthat specialize in mathematical statistics, which handles statistical inference
logic mathematically. Tokyo University of Science also has the distinction of
being strong in medical statistics, as it used to host a medical statistics
program for the working members of society. Therefore, we aim to create a
research stronghold where the researchers in these fields can come together
and actively interact with members from across all campuses anddepartments to conduct research“unique to Tokyo University of Science”.
Furthermore, establishing this department will bring together researcherswith specialties in different research topics but with a shared interest in acommon theory. Our goal is to increase the level of research on essential
theories and methods, and to create new theories and introduce new fields
in the era of data science.

Members of Statistical Science Research Division
Name

Job title

ANDO Shin

Professor, School of Management, Department of Business Economics

HASHIGUCHI Hiroki

Professor, Faculty of Science Division I, Department of Applied Mathematics

IWASHITA Toshiya

Professor, Institute of Arts and Sciences, Noda Division, Institute of Arts and Sciences

KUROSAWA Takeshi

Professor, Faculty of Science Division I, Department of Applied Mathematics

MATSUZAKI Takuya

Professor, Faculty of Science Division I, Department of Applied Mathematics

MIYAOKA Etsuo

Professor, Faculty of Science Division II, Department of Mathematics

MURAKAMI Hidetoshi Professor, Faculty of Science Division I, Department of Applied Mathematics
NISHIYAMA Takahiro ** Professor, Senshu University, Department of Business Administration
SEO Takashi *Professor, Faculty of Science Division I, Department of Applied Mathematics

SHIOHAMA Takayuki ** Professor, Nanzan University, Department of Data Science
SOZU Takashi

Professor, Faculty of Engineering, Department of Information and Computer Technology

TAHATA Kouji

Professor, Faculty of Science and Technology, Department of Information SciencesTERUI Nobuhiko

Professor, School of Management, Department of Business Economics

TOMIZAWA Sadao

Professor, Faculty of Science and Technology, Department of Information Sciences

TSUBAKI Michiko

Professor, School of Management, Department of Management

WATANABE Yuki

Professor, Organization for Education Advancement, Center for Teacher Education

YABE Hiroshi

Professor, Center for Data Science

KAWASAKI Tamae ***Associate Professor, Aoyama Gakuin University, College of Economics

KOIZUMI Kazuyuki *** Associate Professor, Juntendo University, Faculty of Health Data Science
NAKAGAWA Tomoyuki *** Associate Professor, Meisei University, School of Data Science
SHIMOKAWA Asanao

Associate Professor, Faculty of Science Division II, Department of Mathematics

SHINOZAKI Tomohiro

Associate Professor, Faculty of Engineering, Department of Information andComputer Technology

ANDO Shuji

Junior Associate Professor, Faculty of Science and Technology, Department ofInformation Sciences

HU Yannan

Junior Associate Professor, Faculty of Science Division I, Department ofApplied Mathematics

ISHII Aki

Junior Associate Professor, Faculty of Science and Technology, Department ofInformation Sciences

YAGI Ayaka

Junior Associate Professor, Faculty of Science Division I, Department ofApplied Mathematics

EGASHIRA Kento

Assistant Professor, Faculty of Science and Technology, Department ofInformation Sciences

KITANI Masato

Assistant Professor, Faculty of Science Division I, Department of Applied Mathematics

SHIMIZU Koki

Assistant Professor, Faculty of Science Division I, Department of Applied Mathematics

YAMAGUCHI Hikaru

Assistant Professor, Faculty of Science and Technology, Department ofInformation Sciences

Research Group
This research department is roughly divided into two groups that conducts
research in the following fields.
1. Mathematical Statistics Basis Group(Leader: Hiroki Hashiguchi (Department of Applied Mathematics, Faculty of
Science Division I))
The “multivariate analysis group”comprises faculty members from
Kagurazaka, Katsushika, and Noda Campuses and visiting associate
professors. Focusing on the existing research themes of each faculty member,“multidimensional missing data analysis”,“high-dimensional data analysis”,“random matrix theory”, and“dimension reduction method”, we will conduct
research with a view to developing the Applied Statistics Research Group.
The“statistical model group”comprises faculty members from Kagurazaka
and Noda Campuses and conducts research on topics such as“statisticalmodeling and model selection”,“nonparametric methods”, and“contingency
table analysis”. The method, handled by the Mathematical Statistics BasisGroup, has a clear theoretical background and acts as a white box. However,
the method of solving a“real-world problem”has a black-box aspect, suchas in heuristics and deep learning. In constructing the theory of AI and data
science, how to clarify the black-box-like solution of the latter using themethodologies of the former, as well as other methodologies, will be asked.
2. Applied Statistics Research Group(Leader: Takashi Sozu (Department of Information and Computer Technology,
Faculty of Engineering))
In the field of“medical statistics (biostatistics)”, the faculty members of
Katsushika Campus will conduct research activities related to themethodology of research design and data analysis, focusing on medical
research. Research on the development of educational methods and systems
via quantitative analysis in“educational engineering”will be conducted
mainly by the faculty members from Kagurazaka Campus. Additionally, inrecent years, the field of“sports statistics”has been gaining attention, andthe faculty members from Noda Campus, visiting professors, and visiting
associate professors are actively conducting research in this field. Moreover,
we plan to conduct joint research involving student exchange programs.
Regarding the“statistical machine learning/mathematical optimization
field”, research on“natural-language processing that integrates statistical/
machine learning and symbolic modeling”,“large-scale nonlinear optimization
problems related to big-data analysis and machine learning”, and“statisticalmethods for computer-based data mining and pattern recognition”will be
conducted mainly by the faculty members from Kagurazaka Campus.
Moreover, regarding one of the objectives of this research department,“collaboration with external institutions, such as companies, through a Data
Science Center”, a“data analysis team”, which comprises research coordinators
appropriate for each research content, will be formed, and joint research will be
conducted.

*Director, **Visiting Professor, ***Visiting Associate Professor
Tokyo University of Science27

Information and Societal
Established: April, 2021

takemura@rs.tus.ac.jp

Parallel Brain Interaction
Sensing Division

Director
Professor,
Department of Mechanical andAerospace Engineering,
Faculty of Science and Technology

Hiroshi Takemura
Doctor of Engineering

Objectives

Our goal is to proceed from the conventional brain research and technology
development focused on a single individual, creating a new brain research area
analyzing the multiple brain interaction.

Future Development Goals

We will have several open seminars and workshops to find a common language
for researchers in multidisciplinary fields, educate the young investigator andstudents, increasing the integration of researchers.

This division brings together researchers from both
inside and outside the university in the field of thebrain science and neural information and systems tocreate an innovative academic field, “Parallel Brain,”originating from the Tokyo University of Science.
We aim to reveal how the brain activity of multiple
individuals interacts with each other.

Toward Next-generation Brain Project: Knocking new era of IoB (Internet of Brains)
Background and purpose of the division
Neuroscience (brain science) is a field of life science that is dramaticallydeveloping in the 21st century. People expect that, the maintenance of brain
health will improve the quality of life in an aging society, and the applicationof information processing mechanisms in the brain lead to the creation of
innovative technologies. In recent years, most thing have been connected to
the Internet (IoT: Internet of Things), and wearable devices such as
smartwatches have made it possible for humans to connect to the Internet
without even realizing it (IoB: Internet of Bodies). It is easy to imagine thatthe next era will happen the human mind is connected to the Internet (IoM:
Internet of Minds). This is indeed the arrival of the era of the Internet ofBrains. This division will establish a multidisciplinary and interdisciplinary
research and development platform by concentrating the multidimensionaland multiaxial expertise and information on the brain and neural information/systems, and by collaborating with related researchers outside of theuniversity. We aim to create an innovative academic field of brain science,“Parallel Brain,” which will be developed at the Tokyo University of Science inpreparation for the coming era of the Internet of the Brain.

Research Organization and Members
We will propose technology for sensing and reproducing biologicalinformation based on the knowledge of brain research by synchronous(parallel) measurement of the brains of multiple individuals using brain
research methods for mice and humans, which will become our original
interdisciplinary brain research field. This division aims to elucidate andsupport the mechanisms of group formation and symbiosis in online space,
and to build a theoretical background to describe the interaction between
multiple brains common to social animals by using the common sensing
technology in both mouse and human experiments through mathematicalmodels. This division consists of three groups, and seeks to produce
emergent results through synergistic effects among these groups.
Animal experiment group (mouse/human)This group conducts multidimensional research on brain health anddiseases focusing on cognition (depression characterized by pessimistic
cognition, senile dementia with impaired cognition and memory functions,autism with impaired social cognition and communication, etc.), frommolecular and neural circuits to animal models, to elucidate related
mechanisms, and to create seeds for improvement drugs and diagnostic
agents. We aim to create the seeds for new drugs and diagnostics.
Sensing GroupThe Sensing Group conducts multidimensional research on the analysis
and evaluation of brain dysfunction concerning personality traits focusing ongaze behavior and physiological indicators in developmental disorders, etc.,
and aims to create related measurement technologies and assistive devices.
Mathematical Model Group
The Mathematical Modeling Group aims to develop models and theoriesof brain information processing systems based on the results ofmultidimensional studies of functional brain imaging, cognitive psychology
experiments, brain-type algorithms, etc., with a focus on human visual
perception.

28

Tokyo University of Science

The division consists of 17 researchers in interdisciplinary neurosciencerelated fields, including the Faculty of Science and Technology (Hiroshi
Takemura, Takeo Ushijima, Takahiko Yamamoto, Akari Hagiwara, Takumi
Asakura, Masataka Yamamoto), the Faculty of Pharmaceutical Sciences(Akiyoshi Saito, Daisuke Yamada), the Research Institute for Biomedical
Sciences (Takeshi Nakamura, Shingo Koinuma), the Faculty of Engineering(Osamu Sakata, Takuya Hashimoto), the Faculty of Advanced Engineering (Eri
Segi (Nishida), Kanzo Suzuki), the Institute of Arts and Sciences (Hiroko
Ichikawa), and two visiting researchers: Ryohei Hasegawa from the National
Institute of Advanced Industrial Science and Technology (AIST) and Asami
Oguro-Ando from the University of Exeter Medical School.
We are mainly engaged in collaborative and cooperative research use of
the unique talents and strengths of each member. The following is a list ofongoing collaborative research projects that transcend the boundaries ofeach specialized field, which are possible only in this division. For details,
please see the division’s website.
・Elucidation of brain functions controlling social behavior(Prof. Segi and Prof. Oguro-Ando [University of Exeter])・Investigation of cross-species vocal communication(Prof. Ichikawa, Prof. Saito, and Prof. Yamada)・Examination of cross-species vocal communication: Relationship between
ultrasonic vocalizations in mice and the effects of ultrasonic listening in humans(Prof. Ichikawa, Prof. Saito, Prof. Yamada, and Prof. Asakura)・Analysis of Stress-Induced Depression-like State(Prof. Saito, Prof. Yamada, Prof. Takemura, and Prof. Yamamoto)・Study on the Relationship between Human Gait Behavior and Personality Traits:
Extraction and Evaluation of Gait Characteristics Derived from Human Internal State(Prof. Ichikawa, Prof. Takemura, and Prof. Yamamoto)・Biomechanical Analysis of Age-Dependent Gait Deficiency in Cerebellar
Neural Transmission Deficient Mice
(Prof. Hagiwara, Prof. Takemura, and Prof. Yamamoto)・Evaluation of the neural basis of stress sensitivity in synaptic protein-deficient mice
(Prof. Hagiwara, Prof. Saito, Prof. Yamada, Prof. Takemura, and Prof. Yamamoto)・Analysis of Jakmip1-deficient mice, a mouse model for autism(Prof. Saito, Prof. Oguro-Ando, Prof. Hagiwara, Prof. Yamada)・DNA methylation analysis in various mouse models(Prof. Oguro-Ando, Prof. Segi, Prof. Saito, Prof. Hagiwara, Prof. Yamada)Information and Societal
Established: April, 2021

mune@rs.tus.ac.jp

Director
Professor,
Department of Information
Sciences,
Faculty of Science and Technology

Division of Digital Transformation

Munehiro Takimoto
Ph.D.

Objectives

D evelo p m e nt of n ew integ rate d big dat a p ro cessing man n e rs th ro ug hbreakthrough on mathematical theories in theory level, modeling methods infundamental level, and statistical analyses of results in application level.

Future Development Goals

Development of big data processing manners that give accurate predictions forpractical missions through mutually and spirally reflecting feedbacks between
machine learning systems and statistical analyses of their results.

This research division aims to give high-performanceand more accurate big data processing manners withmutual feedbacks between machine learning systems
and statistical analyses of their results, based onmathematical foundations in various levels. The
processing manners include redesign from theory andimplementation of systems and analyses. We believethat the challenges of this division will open newhorizons for big data processing.

R&D on integrated big data processing manners based on new theory and implementation.
They include mathematically redesigning machine learning systems and implementing highaccurate and safe A.I. In addition, they achieve high confidential big data processing, throughstatistically analyzing the results generated by the systems.
Introduction and BackgroundIn most science areas, which include DNA & molecule designs in micronlevel and earth environment sciences in macro level, it is so important to
extract meaningful information from big data, which is superficially uselessdata with huge size. The extraction techniques are called data mining. Datamining is so costly that it is difficult to process it in traditional ways. To
achieve much more efficient and accurate data mining and result ininnovative science technologies, we have to propose new approaches basedon mathematical theorems in algorithms and execution styles.
Division of Super Distributed Intelligent Systems, which is the previous
division, especially focuses attention to medical and bio-systems, and has
developed next generation data mining softwares together with researchers
in artificial intelligence and statistics areas. In the process of that, we havefound that we have to not only enhance parallelization/distribution andpropose new approaches based on mathematical theorems to achieve new
innovative technologies. In Division of Digital Transformation, we will improve
the results of the previous division, and develop new big data processing
manners based on performance and accuracy issues that the results have
exposed. For example, we will continuingly enhance execution efficiency inthe low level that is related with programming languages, parallel/distributed
algorithms, and network protocols. In addition, we will design new deeplearning manners based on adjusting their super-parameters based on
combinatory theorem. Eventually, we will apply these techniques and models
to several areas such as image processing, power systems, machine learning,
robot systems, software engineering tools and so on, including data mining.

Research Topics
We currently have two main projects as follows:① Genomix Data Science Medical Care of Cancer
It is a project that is advanced with National Cancer Center Exploratory
Oncology Research & Clinical Trial Center (NCC-EPOC) as a cooperative
research (Fig. 1). In this project, the purposes in the applicative level arecancer prevention, lengthening the time of a healthy life, improvement ofquality of life and rehabilitation. Also, we are developing methods special toeach applicative level purpose through fusing data sciences such as
mathematical statistics, machine learning, information processing andstatistical analysis, and cancer biological experiments.

Research Hierarchy
We address the issues of big data processing in three hierarchical levels,“applications”,“fundamentals, and“theories”as follows:
1.Applications
In this level, members who are specialists of each applications investigate
issues of the applications based on their expertise, propose approaches tosolve the issues, and check validity of results given by the solution. In theprocess, they give new models based on characteristics of the applications,and develop systems implementing the models. The results given by thesystems are validated in mathematical methods.

Fig. 1

Genomix Data Science Medical Care of Cancer.

② Implementation and Practical Realization of Cerebral Apoplexy Prevention by AI
We are developing the system that enables AI to support a doctor
medically examining or treating patients of cerebral apoplexy using medical
big data and engineering big data. This project was conducted as one of
NEDO projects, implementing two kinds of A.I.s, which were A.I. α based onjust medical information and A.I. β based on both of medical information andengineering information.

2.Fundamentals
In this level, members directly improve performance of fundamental
techniques such as A.I. and machine learning, and propose new approachesof them. The improvement of performance includes network performance indistributed systems and sensor networks, and learning performance of A.I.
through parallel and distributed techniques. The new approaches include
improvements of parallelism in instruction level on GPU, improvement of
accuracy of existing machine learning, and development of new machinelearning model based on biological systems. The fundamental techniquesand systems developed in the level are validated in mathematical methods.
3.Theories
In this level, members give proofs of techniques with black box parts suchas deep learning and machine learning. Furthermore, through knowledges
obtained in the process, they propose new methods or system models.
Fig. 2

Cerebral Apoplexy Prevention by AI.

Tokyo University of Science29

Information and Societal
Established: April, 2022

akimoto@rs.tus.ac.jp

Director
Professor,
Department of Pharmaceutical
Sciences

Medical Data Sciences

Kazunori Akimoto
Ph.D.

Objectives

Toward the realization of “Medical Data Sciences” based on digital medical
data, we aim to solve the needs of clinical sites using data science methods andidentify novel biomarkers for stratification.

Future Development Goals

In addition to the multifaceted analyses of global public medical data, it isexpected that the unique “Medical Data Sciences” will be established bypromoting cooperation with the National Cancer Center.

This division has been launched by a group of
researchers specializing in data sciences and cancer
biology, crossing the boundaries of the faculties andcampuses of TUS. We aim to construct “Medical Data
Sciences” at TUS by forming a network both insideand outside TUS, such as in collaboration with the
National Cancer Center.

Construction of “Medical Data Sciences” establishing novel preventive andtherapeutic methods for diseases at TUS
Objectives

Current Situation of “Medical Data Sciences”

The realization of “Medical Data Sciences” is becoming indispensable forestablishing preventive and therapeutic methods for the cure of diseases. In
medical care, Precision Medicine is being established: patients are stratified
into specific groups by analyzing various medical big data, and theappropriate treatment is precisely selected for each patient group. However,at present, there are various problems pose barriers and is a limit to theprovision of precise medical care. The purpose of launching this division is
combined with data science methods and cancer biological methods tosolve the medical problems by the collaboration between NCC-EPOC and
TUS. The outcomes are expected to prevent cancer progression, extend
healthy life expectancy, and realize high QOL and rehabilitation of cancer
patients.

Attempts to solve medical problems with data science methods havebecome a global trend. Such efforts are also being actively carried out inJapan. This division uses NCC and global medical databases as medical
sources and needs, but is characterized by using the data science methods
accumulated at TUS. This is made possible by gathering specialists highly
specialized data science and cancer biology of TUS. Although the network
scale of researchers is smaller than the global networks by other groups, it
secures the diversity of researchers’ specialties and enables them tocooperate closely and flexibly carry out research activities.

This division will promote new patient stratification and proposals fortreatment methods by using data science research on medical big data as astarting point. There are various challenges to be overcome in the realizationof “Medical Data Sciences”. Therefore, we will make full use of data science
methods accumulated in TUS to solve the problem and develop thetheoretical foundation for proposing new therapeutic agents and treatments.
A series of research will enable the creation of new academic fields and theestablishment for the theoretical foundation of “Medical Data Sciences”.
Furthermore, we will promote next-generation education and thedevelopment of researchers who will adapt and develop “Medical Data
Sciences” based on medical big data.

Digital Transformation

NCC

Big data processing
Medical sources and needs

Medical Data
Sciences
Mathematical andapplied statistics

Nucleic acid-based drug

Statistical Science Research

Nucleic Acid Drug Development
Faculty of Pharmaceutical Sciences

Synergistic effects

30

Tokyo University of Science

Faculty of Science and Technology
Research Institute for Biomedical
Sciences

Information and Societal
Established: April, 2022

t_yamamoto@rs.tus.ac.jp

Director
Associate Professor,
Department of ElectricalEngineering,
Faculty of Science and Technology

Division of Smart Healthcare
Engineering

Takahiko Yamamoto
Ph.D.

Objectives

This division aims to conduct interdisciplinary research that contributes to thecreation of a smart, healthy, and longevity society by researchers in a wide rangeof fields, including physiology, materials engineering, metabolism, integrated circuit
engineering, radio frequency systems, and wireless communication engineering.

Future Development Goals

We are promoting active interactions among division members covering a wide
range of specific fields, to emphasize joint research within and outside TUS, andto encourage young researchers.

This division conducts basic and interdisciplinary
research on basic technologies and cross-disciplinary
related to biometric sensing for health diagnosis
to telemedicine, and high-quality, secure wirelesscommunication, with the aim of supporting a smart,healthy, and longevity society in which people canlead healthy and high quality of life.

Creation of a Smart, Healthy, and Long-Lived Society that Supports People’s Daily Life
with High Quality of Life
The stresses that people may experience in their daily lives in society, even if
they seem small and insignificant, increase the risk of various diseases. Researchis needed to create a society in which people can live healthy daily lives with ahigh quality of life, even when their physiological functions are impaired or lost
due to disease. This division advocates the value of smart healthcare systems
that support to realize such a society and conducts research on thedevelopment of elemental technologies and their effective integrations.

Research Structure and Members of this DivisionThis division is divided into four major groups, and some of their research
activities are presented below.
○ Sensing Group・Elucidation of the mechanisms of health promotion and longevity throughphysical activity
Based on exercise physiology, behavioral physiology, material science, andmetabolism, this group uses non-contact methods to quantify the amount ofphysical activity using animal models and explore the optimal amount ofphysical activity for physical and mental health in order to elucidate themechanisms of health promotion and longevity from daily physical activity.
・Analysis of nanoscale materials derived from skeletal muscle/fat tissue on
physical function and mental health
Quantitative visualization of various mental and physical functions in humans
is being attempted. In particular, Yanagita, Umezawa, and Kobayashi in our
members have collaborated on a health promotion/longevity mechanism
through exercise that is opened up by brain-organ communication, and are
currently working on a research project to reveal the mechanism of brainperipheral organ communication associated with changes in the amount ofphysical activity. The physicochemical and biological properties of nanoscale
structures produced and released by muscle and fat cells in response toenvironmental stimuli are also being studied to visualize brain-organ
communication.
○ Device Operation and Control Group・Transcutaneous energy transmission for body-implanted electronic devices
Transcutaneous energy transmission and information transmission systems
for medical electronic devices implanted inside the body are studied. Thissystem completely reduces the risk of infection when supplying the driving
energy essential for device operation. and achieves miniaturization andweight reduction through battery-free operation (Figure 1).
・Development of an electromagnetic phantom
When conducting wireless power or information transmission between
inside and outside living organisms, it is essential to investigate the effects ofthe presence of living bodies on the operation of the equipment and theelectromagnetic radiation from the equipment to ensure stable operation of
the equipment. By using materials that mimic the electromagnetic propertiesof living bodies, these studies can be performed without animal experiments.
In this research, we are developing various types of simulated living organisms.

Figure 1

Wireless power transmission to an implantable momentum meter○ Integrated Circuits and Signal Processing GroupThe Transmission Group and the Information and Communication Group
conduct research on high-frequency and high-speed signal processing circuits,
low-voltage and low-power circuits, and their miniaturization, which areessential for hardware implementation. We develop high-performance amplifiers(low noise, high input impedance), analog-to-digital conversion circuits (ADC),
and digital-to-analog conversion circuits (DAC) with high resolution and low
power consumption, which are essential for measuring minute bioelectric
potentials. In addition, as sensing devices become increasingly popular, we are

analyzing device variation and studying variation-resistant circuits to realize
robust circuits that are low-cost and highly resistant to variation.
○ Information and Communication Group・Small antennas installed near living bodies
We are researching and developing compact, high-gain biometric antennas
that can be used near living bodies and are not easily affected by them.
・Low power, high quality and secure wireless communication
This group is researching communication methods that achieve high speed, large
capacity, high quality/low latency, multiple simultaneous connections, and low
power consumption without degrading transmission quality. These are envisioned
for transmitting biometric and other information measured by the sensing group to
medical facilities using wireless communications. In addition, research will be
conducted to promote the safe and secure use of radio waves by protecting
information and communications from unauthorized access and malicious attacks.
Table 1Affiliation

Member and Main Research Field
Job title

Name

Main research field

Group

Associate
Department of Electrical Engineering,
Professor,
Faculty of Science and Engineering
Director

Takahiko Yamamoto

Medical Electronic
Systems

Device Operation
and Control

Department of Electrical Engineering,
Professor
Faculty of Science and Engineering

Kenichi Higuchi

Wireless Communications

Information andCommunication

Department of Electrical Engineering,
Professor
Faculty of Science and Engineering

Akira Hyogo

Integrated
Electronic Circuits andCircuits and Signal
Integrated Circuits
Processing

Department of Information Science,
Faculty of Science and Engineering

Professor

Shigeo Akashi

Information Theory

Information andCommunication

Department of Pharmacy, Faculty of
Pharmaceutical Sciences

Professor

Akiyoshi Saito

Pharmacology

Sensing

Noda Division, Institute of Arts andSciences, Institute of Arts and Sciences

Professor

Shinya Yanagita

Neurology andExercise Physiology

Sensing

Department of Medical and Robotic
Engineering Design, Faculty of
Advanced Engineering

Associate
Professor

Pharmaceutical Science
Masakazu Umezawa and Materials
SensingEngineering
Information andCommunication

Department of Electrical Engineering, AssistantFaculty of Science and Engineering
Professor

Takanori Hara

Department of Electrical Engineering, AssistantFaculty of Science and Engineering
Professor

Integrated circuits,
Ryoichi Miyauchi biological signal
measurement systems.

Integrated
Circuits and Signal
Processing

Department of Pharmacy, Faculty of
Pharmaceutical Sciences

Assistant
Professor

Daisuke Yamada Neurochemistry

Sensing

Department of Medicinal and Life
Sciences, Faculty of Pharmaceutical
Sciences

Assistant
Professor

Yuka Nozaki

Functional
biochemistry

SensingKohji Koshiji

Radio systems andmedical electronics

Device Operation
and Control

Department of Electrical Engineering, Visiting
Faculty of Science and Engineering
Professor

Wireless Communications

Tokyo City University

Visiting
Professor

Tatsuji Matsuura

Integrated
Integrated Circuits andCircuits and Signal
Signal Processing
Processing

Tokyo Polytechnic University

Visiting
Professor

Fukuro Koshiji

Bio-Communication

Information andCommunication

Nippon Medical School

Visiting
Professor

Shoji Yokobori

Emergency Medicine

Clinicalengineering andmedicine

Nippon Institute of Technology

Visiting
Kenko Ohta
Researcher

Emotion Analysis

Sensing

Tokyo International University

Visiting
Natsuko Kubota
Researcher

Physiology

Sensing

Tokyo Institute of Technology

Visiting
Hiroki Sato
Researcher

Integrated
Integrated circuits andCircuits and Signal
software engineering
Processing

Ochanomizu University

Visiting
Masaki Kobayashi Metabolism
Researcher

SensingToyama Prefectural University

Visiting
Ryo Kishida
Researcher

Integrated Systems
and Reliability

Integrated
Circuits and Signal
Processing

ZENKIGEN

Visiting
Issei Hashimoto
Researcher

Sensitivity Engineering Sensing

Jichi Medical University Saitama
Medical Center

Visiting
Chinori Umeda
Researcher

Clinical engineering

Clinicalengineering andmedicineTokyo University of Science31Fundamentals
Established: April, 2020

kato@rs.tus.ac.jp

Director
Professor,
Department of Mathematics,
Faculty of Science

Research Alliance forMathematical analysis

Keiichi Kato
Mathematical Sciences

Objectives

To make interdisciplinary researches with researchers of mathematical analysis,numerical analysis, physics, chemistry, biology and engineering

Future Development Goals

We make research alliance with other divisions in our research institute andinstitutes outside the university

This division has been established on the April of2020, as the succession of Division of Mathematicalmodeling and mathematical analysis. Our aim is
to make interdisciplinar y researches bet ween
mathematical analysis, numerical analysis, physics,
chemistry, biology and technology. The membersof our division are willing to cooperate to those
who need to techniques of mathematical analysis,numerical analysis or theoretical physics.

Interdisciplinary researches between mathematical analysis, science and engineering
This division has been established on the April of 2020, as the successionof Division of Mathematical modeling and mathematical analysis. The aim ofour division is to make alliance research over mathematical analysis,numerical analysis, physics, chemistry, biology and engineering.

Alliance inside the division
We make research alliance based on Three groups(Group of mathematicalphysics, Group of mathematical biology and Group of mathematicalengineering).

・Group of mathematical engineering
This is a research group focused on mathematical analysis of various
phenomena in continuum mechanics and applying to inverse problems.
Especially, we study fracture phenomena for elastic structures, motion ofvortex filaments, faulting rupture in seismology and so on. As regards inverse
problems, we deal with reconstruction problems for discontinuity embedded
in a medium, such as cracks, cavities, inclusions and obstacles, fromobserved data, which are arising from non-invasive tests for a living body,non-destructive tests in engineering and inversion of source process inseismology. The aim of the group is to provide theoretical foundations andtheir numerical implementation.

・Group of mathematical physics
The aim of the group is to establish original numerical method for
Schrödinger equations based on representation of solutions via wave packet
transform due to K. Kato et al. and apply it to condensed matter physics. We
have succeeded to establish original numerical method and are applying it tocompute numerical solutions of Schrödinger equations.

Alliance with other divisions in RIST・Group of mathematical biology
We investigate asymptotic behavior of solutions of mathematical models
including epidemiological models and Keller–Segel system for cancer
invasion. One of our study is a free boundary problem that describes thespatial propagation of a transmitted disease. By a joint work among E.
Ishiwata, T. Ushijima, Y. Enatsu, we have obtained a new result for existence
and nonexistence of a traveling wave solution (a solution propagating in a
direction with the same profile and the same speed). Starting February 2018,
we have organized regular seminars relating to infectious diseases in
Kagurazaka campus. In the seminar, talks on infectious diseases are given byresearchers in the field of mathematics, biology, medical science.

32

Tokyo University of Science

From the beginning of the 21st century, the importance of mathematics has
been known more and more even in our country. In the research institute for
Science and technology(RIST), we have two mathematical division: thisdivision and the division of modern algebra and cooperation ofengineering(DMACE). We will make research alliance with other divisions
such as divisions of condensed matter physics, divisions of chemistry,
divisions of biology and divisions of engineering with cooperation of DMACE.

Alliance with other institutes
On the January of 2020, we have concluded the agreement for researchalliance between RIST and Research Alliance Center for Mathematical
Sciences(RACMaS) in Tohoku University. We will promote research alliance
between this division and RACMaS based on the agreement. We also try to
make research alliance with other institutes.

Fundamentals
Established: April, 2020

tsai@rs.tus.ac.jp

Director
Professor,
Research Institute for Scienceand Technology

Division of Nano-quantum
Information Science and Technology

Objectives

Our research division aims at optimization of the operation condition forsuperconducting, optical and spin qubits.

Future Development Goals

This division will contribute to the practical realization of the quantum computer
thirty years later.

Tsai Jaw-Shen
Ph.D.
T he research of quantum co mputer has b een
very active during the recent years. One of thereasons of the rapid progress is the improvement incoherence time of the qubit due to the advancementof nanotechnology. However, the current statusof the quantum circuit is still far from the real
implementation. We must accelerate the pace of
research and development toward the truly faulttolerant quantum computer.

Nanotechnology and its applications to quantum information and electronics
BackgroundIn recent years, demonstrations of quantum supremacy by Google andlater the University of Science and Technology of China, the establishment ofIBM’s commercial quantum computer, and the D-Wave System’s 4,000-bit
quantum annealing machines, quantum information processing has maderemarkable progress. All of the above systems are based onsuperconducting qubits, but quantum computing systems based on othersystems such as light, semiconductors, and ions are also being actively
researched around the world.

Yoshihara, Takayanagi, Watabe and Hashizume join this program.
This program continues until 2025（https://ms-iscqc.jp）.

Collaboration with the University of Tokyo
Other research activity of the division is the collaborated one with the
University of Tokyo. The partner organizations are the Institute for Nano
Quantum Information Electronics（http://www.nanoquine.iis.u-tokyo.ac.jp/）
and Quantum Innovation Co-creation Center. The research subject isquantum optics utilizing single photon. Drs. Sanaka, Sadgove, andTkachenko join this activity.

Our targets
Our division mainly investigate the superconducting qubit. Qubit cause
errors like ordinary classical semiconductor circuits. Malfunction of the qubit
also would come from the breakdown of the quantum superposition state.
Such phenomenon is called decoherence. The fault-tolerant quantum
computer would be realized by employing a quantum error correction
procedure, and it would deliver truly practical applications. The divisionplans to carry out research of several kinds of fault-tolerant quantum circuitswith superconducting qubits. It is expected that the fault-tolerant quantum
computer would appear by 2050, and we would try to contribute to its
realization.
Superconducting qubit is considered as the most suitable platform for thequantum computers. However, it also has its problems. The coherence timeof superconducting qubit is still short, for example. Beside thesuperconducting qubit, qubits based on other physical systems, like photon,
ion, atom and electron spin in quantum dot have been investigated earlier. In
our division, spin qubit and optical qubit will also be investigated, along withthe superconducting qubit.

Moonshot Research & Development ProgramMembers
Affiliation

NameTokyo University of Science

Jaw-Shen Tsai

Tokyo University of Science

Kaoru Sanaka

Tokyo University of Science

Mark Paul Sadgrove

Tokyo University of Science

Fumiki Yoshihara (June, 2022 - )Tokyo University of Science

Noboru Watanabe

Tokyo University of Science

Satoshi Iriyama

Tokyo University of Science

Takeo Kamizawa

Tokyo University of Science

Yoichiro Hashizume

Tokyo University of Science

Georgiy Tkachenko (July, 2022 - )The University of Tokyo

Hideaki Takayanagi

Shibaura Institute of Technology

Shohei Watabe

The University of Tokyo

Yasuhiko Arakawa

Riken

Seigo Tarucha

NEC

Tsuyoshi Yamamoto

NTT

Shiro Saito

Fig. 2

 -bit quantum logic gate. Two transmon-type qubits (cross-shaped structures)2
are connected by a superconducting resonator.

The research subject“Developing bosonic code using superconducting
resonator” was adopted to the government moonshot research &development program in 2020. The program leader is Dr. Tsai and Drs.

Fig. 1

Heart of the dilution refrigerator for superconducting qubits’evaluation.
Multiple wideband signal lines can be seen.

（Tokyo University of Science, Tsai Laboratory)

Tokyo University of Science33

Fundamentals
Established: April, 2021

ito_hiroyuki@rs.tus.ac.jp

Modern Algebra and Cooperation
with Engineering

Director
Professor,
Department of Mathematics,
Faculty of Science and Technology

Hiroyuki Ito
Doctor of Science

Objectives

To research and develop algebra itself and algebra based engineering, also
to make cooperative research on algebra and engineering, thereby to make acontribution to mathematics and engineering.

Future Development Goals

To make contribution to mathematics and engineering, and to continue to be
the center of research on algebra and its applications to engineering.

This division do research from purely theoreticalmathematics to experimental engineering, and makecooperative environment between mathematicians
and researchers in algebra based engineering.
Furthermore, the division will contribute to makecooperative research bet ween algebra andengineering which induces mathematical innovation.
The division continue to play an important role as theinternational hub for research on algebras.

Theoretical research on algebra and its applications on engineering
Background and purpose of the division
It is important for mathematics, which has more than 2000 years history
for research, to interact with other research fields outside mathematics.
Research area of pure mathematics is roughly divided into three parts,
algebra, geometry and analysis. One can think that algebra and analysis are
two wheels of a cart, via geometry and geometric objects. In its long history,
analysis, which treat mainly continuous objects, has been developed ininteraction with various engineering technology. On the other hand, algebra,
which treat mainly discrete objects, has been started to make interaction
with information science, information technology, electrical and mechanicalengineering, etc., after 20th century, and produce many useful results andeffects which are indispensable for modern human life. Our division based on
algebra are going to cooperate with another division“Research Alliance forMathematical Analysis”, and are going to be a basis of science andtechnology to cooperate with various research areas. And finally, to be acenter of research on algebra and algebra based engineering.

 esearch on Modern Algebra and Cooperation Rwith Engineering
The division consists of various researchers inside Tokyo University of
Science, whose research fields are number theory, arithmetic geometry,algebraic geometry, commutative algebra, representation theory,
automorphic forms, algebraic topology, discrete mathematics, combinatorial
design, computational mathematics, computer algebra, cryptology,
information security, coding theory, applied algebra, and statistical science.
In the past, these researchers have cooperated with each other in theoccasion of seminars, workshops and international meetings. As an activityof this division, we pursue further cooperative relationship not only inside thedivision, but also outside the division, and we are going to produce many
cooperative research between pure mathematics and engineering.
More precisely, the division consists of three groups for purely mathematicalresearch and four groups for applied research. Pure mathematics groups are

34

Tokyo University of Sciencemanaged by holding seminars, workshops and symposiums on algebra,
algebraic geometry, number theory, and so on. Engineering groups are also
managed by making a place for engagement of researchers of pure mathematics
and engineering, and by proposing and developing many research plans forboth sides, mathematics and engineering. Furthermore, the division docooperative research under continuously pursuing the deep cooperation with
Research Alliance Center for Mathematical Sciences, Tohoku University.
There are three special features of this division. 1) The generations ofresearchers are widely distributed. 2) They have enough experiences of joint
research not only for domestic but also for international. 3) The researchers
have been managed continuously various seminars and symposiums inside
Tokyo University of Science.

 bout the Future of Modern Algebra andA
Cooperation with Engineering
Since making relationship between person and person in various research
fields has already done, the next step is expanding the relationship between
person and person to the cooperative relationship between person and group,group and group. Furthermore, develop a new cooperative research fields basedon algebra. Also keep to play an role as an international research hub cooperatewith Research Alliance Center for Mathematical Sciences, Tohoku University.

Established: April, 2022

Open Innovation Project

koho@admin.tus.ac.jp

Director
Associate Professor,
Department of Pure and Applied
Chemistry,
Faculty of Science and Technology

The Kao “Kirei” Future
Open Innovation Project

Isao Shitanda

Objectives

Kao will promote the development of innovative technologies to enrich peopleʼs
lives by collaborating with Kao’s technologies and the TUS’s knowledges inbiochemical science, interface science, and brain science.

Future Development Goals

We will work not only on research and development, but also on contributions
to the SDGs and human resource development. Details of these efforts can befound in the movie ※ at TUS Forum 2021 (Japanese only).
※ URL: https://www.tus.ac.jp/tusforum/2021/archive.html#point03

This open innovation project is a joint research projectb e t w e e n K a o C o r p o r a ti o n (“ K a o”) a n d t h e To k y oUniversity of Science (TUS). This is the first project
designated under the “Open Innovation Projects” systemof the RIST. Kao and TUS are both working to solve
social problems through science and technology, and we
expect significant synergy effects through collaborative
research and development.

Develop innovative technologies to enrich peopleʼs lives
Based on educational philosophy of TUS, “Innovation in Science andTechnology for Sustainable Development”, TUS aims to solve various
problems in society through education and research. In addition, Kao Group
Mid-term Plan 2025 (K25) outlines the company’s direction to “Become acompany that protects future lives” and Kao conducts research anddevelopment to contribute to sustainable society and realization of a richlifestyle culture. Thus, Kao and TUS expect significant synergy effects fromthe collaboration for Kirei—Making Life Beautiful.
Therefore, we have established the “The Kao “Kirei” Future Open
Innovation Project” and started joint research. While recognizing theirrespective social missions and roles, both parties are promoting thedevelopment of innovative technologies to enrich people’s lives.
The following four joint research themes are in progress. We aim tocontribute to the areas of “Ecology”, “Life” and “Everyday lives” through theresearch and development of each research theme.
Theme 1: Research on biofuel cells and biosensors
Theme 2: Research on foaming control and functionalization
Theme 3: Research on neural and molecular mechanisms of pain
Theme 4: Research on application of cellulose nanofiber reinforced resin
composites to structural materials
Theme 1
Research on Biofuel Cells and Biosensors
Innovative development of bio-devices1 ) Investigation of the practical application of health monitoring devices thatgenerate power from the human body2 ) We will study the realization of an ultimate health care device that allows
anyone to manage health information at any time by incorporating biofuel
cells, which provide clean and safe power supply regardless of location,
into wearable devices.

Theme 3
Research on Neural and Molecular Mechanisms of Pain
Innovative development for improvement of low back pain1 ) Elucidation of neural and molecular mechanisms of chronic low back pain2 ) Elucidation of the mechanism of stress-induced aggravation of low backpain and search for treatment methods by modulating brain functions
Through the above, we aim to clarify the relationship between the onset of
low back pain and stress, and to improve low back pain by regulating brain
functions.
テーマ３：腰痛改善のための革新的開発
慢性腰痛モデルの確立

痛み改善時の神経回路・分子メカニズムの解明

腰痛の劇的改善へ
生体機能メカニズム解明
分子
↓↑

薬物

生体
標的分子

神経
↓↑

脳

↓↑

個体

治療効果
（抗うつ効果）
病態（うつ）

病因（ストレス）

Theme 4
Research on Application of Cellulose Nanofiber Reinforced Resin Composites
to Structural Materials
Research on innovative development of CNF reinforced resin composites forinternal localization in carbon fiber reinforced Plastics (CFRP)
1 ) E xplore the application of CNF-reinforced resin composites for highinterlaminar toughness of CFRP composite laminates.
2 ) Explore material design guidelines for the application of CNF-reinforced
resin composites as structural materials.
Theme 4 : Innovative development of localized technology of cellulose
nanofiber reinforced resin in carbon fiber reinforced plastics(CFRP)

テーマ１：バイオデバイスの革新的開発

人体から発電するヘルスモニタリングデバイスの実用化に向けた検討

Theme 2
Research on foaming control and functionalization
Innovative development of foaming control technology1 ) Maximize surfactant performance using small amounts of polymers toachieve comfortable and rich foam with a minimum of materials2 ) Understand the synergistic effects of mixing surfactants and polymers tocreate technologies that can control various foam performances

In addition to research and development on the above existing themes,
discussions are held on the establishment of new themes. In order to discuss
new themes, we will hold a new technology presentation to introduce the
TUS’s technological seeds. Brainstorming sessions are also planned to
discuss the expansion and development of research and development into
new areas. In addition, we also offer special lectures for undergraduate andgraduate students and other human resource development programs to
expand organization-to-organization collaboration.

テーマ２：泡立ち制御技術の革新的開発

Tokyo University of Science35

Open Innovation Project

Established: June, 2022

manabu@rs.tus.ac.jp

Professor
Department of Architecture
Faculty of Science and Technology

Research ＆ Development
Platform of Functional
Green Building Materials
Objectives

Future Development Goals

Director

Manabu KANEMATSU
Ph.D

Our goal is to achieve the societal implementation of environmentally conscious
architecture by developing a system to assess and visualize the life cycle CO₂
emissions of non-structural components, considering their lifespan. Additionally, we
promote research and development of high-performance materials and construction
methods that reduce CO₂ emissions during manufacturing and construction.

We will achieve the design and construction methods with innovative functionalbuilding materials based on new concepts while taking advantage of theindustry-academia collaboration and science-engineering partnership, toward
the ultimate goal of environmentally conscious architecture.

What is Environmentally conscious architecture, and how
should it be designed and constructed? What materials andconstruction methods contribute to that realization? Our goal
is to create and enhance the academic research field thatbridges cutting-edge and fundamental research areas withpractical application areas, bringing together Tokyo Universityof Science's scientific and engineering expertise and Shimizu
Corporation's practical and operational capabilities towards
achieving the design and construction methods required torealize truly environmentally conscious buildings.

Toward the realization of environmentally conscious architecture through research anddevelopment of high-performance materials and design-construction methods contributing to
CO₂ emission reduction
Background and Purpose of the ProjectAs efforts towards decarbonization spread throughout society, the role servedby the construction sector, which forms the foundation of people's activities andlives, is immensely significant. It is essential to conduct a comprehensive
examination that combines the academic foundation required for achieving
highly advanced environmentally friendly architecture with the practical capability
to implement these concepts in the real world. Given the significant advancements
in energy conservation, renewable energy, and CO₂ reduction during the operational
phase of buildings, the proportion of environmental impact generated during
material procurement, production, and construction processes is relatively
increasing throughout the entire building lifecycle. In particular, nonstructuralcomponents, which produce about 20% of the "Embodied Carbon" emissions
during the construction phase, play an important role in controlling the diverse
performance and functionality of spaces. On the other hand, while there are a vast
number of combinations of materials and construction methods, and there havebeen many individual studies on it and social implementations from theperspective of environmental considerations, efforts to optimize the environmental
impact, performance, and functionality of entire buildings have not been sufficient.
This project aims to establish practical design and construction methods
that minimize environmental impacts throughout the entire lifecycle, bydeveloping the evaluation methods for environmentally friendly architecture.
Our fusion research project will serve as a platform for the development of
new functional building materials that bridge advanced foundational researchand practical applications, with the goal of creating new research fields.

(WG1), interior materials (WG2), opening components (WG3), and substratematerials (WG4), which have a significant impact on Whole Life Carbon.

Contribution of this Project
By promoting this industry-academia collaboration project as a comprehensive
project based on open innovation, the project’s two collaborators intend tocreate pioneering examples in a wide range of boundary regions and leadthe way in environmental conservation efforts within the constructionindustry. The realization of this initiatives is expected to result in the following
contributions to the societal issue:
Establishment of an ecologically congruous society via the formulation of
methodologies underpinning design and construction facets of environmentally
mindful architecture.
Pioneering the development and real-world assimilation of novel material
technologies and construction methodologies that underpin environmentallyconscious architectural endeavors.
The crystallization of an integrated framework that fosters both foundational
research and societal deployment, culminating in the creation and implementationof pioneering environmentally conscious technological paradigms.
Nurturing a cadre of adept professionals pivotal to the realization ofenvironmentally conscious architectural endeavors.
Planning

Basic design

Execution

Detailed design

Operation(1) Estimate preparation

Demolition(3) Outputting diﬀerent formats

Automatic one-click conversion

 owards Achieving Environmentally Friendly
T
Architecture through Reduction of Environmental
Impact in Non-Structural Components
In the pursuit of reducing environmental impacts associated with non-structuralcomponents, a comprehensive assessment considering both Embodied Carbon
and operational carbon emissions during the operational phase is necessary toevaluate the entire lifecycle CO₂ emissions of buildings, known as "Whole Life
Carbon." However, the evaluation methodology for Whole Life Carbon has notbeen definitively established. Moreover, it's essential to take into account the
impacts of variations in material production processes, the use of recycledmaterials, and other practical initiatives. However, when compared to structural
materials, the inadequate progress in establishing a comprehensive database fornon-structural materials, which is crucial for accurately calculating Embodied
Carbon, is also a noteworthy concern.
Therefore, this project will advance research and development through theestablishment of the following working groups for "Investigation ofEnvironmentally Friendly Architecture Strategies," which aims to constructevaluation and optimization methodologies for the design and construction ofenvironmentally friendly architecture, as well as "Research and Development ofEnvironmentally Friendly Construction Methods," which involves theimplementation of specific material and construction method developments.
Resource conservationi )Investigation of Environmentally Friendly Architecture
Strategies
Conserving materials and streamlining
structural engineering methods
WG0: CO₂ Reduction Strategy
Developing surface ﬁnishingtechniquesii )Research and Development of EnvironmentallytoFriendly
Construction Methods
ensure freedom of design
WG1: Exterior Materials / WG2: Interior Materials/
High insulation
Embodyingenergy-saving
WG3: Opening Components / WG4: Substrate
Materials
exterior materials
Using exterior materials that
contribute to energy conservation
by reducing the energy requiredfor heating and cooling during theoperationalstage
In the WG0, we aim to construct a system thatassessesand visualizes
Resource recycling
CO₂emissions of non-structural materials at each life
stage. Additionally, we will
Circular economy
promote research and development of materials and methods that achieve a
Proactively utilizing recycled
aluminum and steel
high level of environmental performance and functionality
for exterior materials

36

Tokyo University of Science(2) Automatic conversion

GORLEM CO₂
The system is capable of outputting
data in formats that are compatible
with diﬀerent methods.

Shimizu estimate system

Embodied carbon is derived at the basic design stage through the use of an automated platform (belonging to
Shimizu Corporation) for calculating CO₂ emissions associated with construction and production.

Items

A

B

C

D

E

F

Total ﬂoor area (m²)

3,700

4,100

6,500

7,500

16,00019,000CO₂ emissions(kg-CO₂ / m²)

1,300

1,300

1,200

1,200

1,100

1,400

40

40

42

43

46

42

12

11

12

10

12

11

Building frame (%)
Exterior materials (%)
Interior materials (%)

8

9

7

6

4

12

Other

Building
frame:
40‒46
Interior/
exterior
materials:
16‒23

Examples of life cycle CO₂ calculation results (six office building examples) are basedon the“LCA Guidelines for Buildings”published by the Architectural Institute of Japan
Interior and exterior materials (non-structural components) play a functional role indetermining the direct performance of buildings, and their share of CO₂ emissions
cannot be ignored.
Resource conservation
Conserving materials and streamlining
structural engineering methods
Developing surface ﬁnishingtechniques
to ensure freedom of design

High insulation

木材活用
Wood
utilization

Longer service life
Ensuring high durability

ウッド・ファースト
Encouraging
the use of wood

Reducing deterioration andcontrolling the eﬀects
of aging through structural
engineering methods

木材の積極利用へ
Activelyusing wood

Embodying energy-saving
exterior materials
Using exterior materials that
contribute to energy conservation
by reducing the energy requiredfor heating and cooling during theoperational stage

Resource recycling
Circular economy

高断熱化
High
insulation
Wood utilization
Encouraging the use of wood
Making improvements thatencourage the utilization ofwood

Improving the performance offoundation materials and
下地材や断熱材の性能向上へ
insulation materials

Using interior materials that
contribute to energy conservation
運用段階の冷暖房電力を削減
by reducing the energy required forheatingand cooling during the
省エネに寄与する内装へ
operational stage

Proactively utilizing recycled
aluminum and steel

Longer service life
Ensuring high durability
Reducing deterioration andcontrolling the eﬀects
of aging through structural
engineering methods

木材活用
Wood
utilization
ウッド・ファースト
Encouraging
the use of wood

木材の積極利用へ
Activelyusing wood

高断熱化
High
insulation
Wood utilization
Encouraging the use of wood
Making improvements thatencourage the utilization ofwood

Improving the performance offoundation materials and
下地材や断熱材の性能向上へ
insulation materials

Using interior materials that
contribute to energy conservation
運用段階の冷暖房電力を削減
by reducing the energy required forheatingand cooling during the
省エネに寄与する内装へ
operational stage

Examples of efforts aimed at achieving environmentally friendly construction

RIST Organization Chart
Chairman of
the Board ofGovernors

Research Institutefor Science &Technology

Research Centers● Center for Fire Science and Technology● Water Frontier Research Center● Research Center for Space System Innovation [ SSI ]● Research Center for Drug Discovery and Applied Sciences

Joint Usage / Research Center● Research Center for Fire Safety Science

Research Divisions

President

OrganizationforResearch
Advancement

Research Institutefor Science &Technology

Research Institutefor Science &Technology
Steering
Committee★ Carbon Value Research Center★ Research Center for Multi-Hazard Urban Disaster Prevention● Development of superior cell and
DDS for regenerative medicine● Division of Biological Environment Innovation● Division of Colloid and Interface Science● Division of Composite Materials Engineering● Division of Digital Transformation● Division of Implementation of sustainable
technology in society● Division of Nanocarbon Research● Division of Nano-quantum Information Science andTechnology● Division of Nucleic Acid Drug Development● Division of Smart Healthcare Engineering● Division of Synthetic Biology● Medical Data Sciences● Modern Algebra and Cooperation with Engineering● Parallel Brain Interaction Sensing Division● Renewable Energy Science &Technology Research Division● Research Alliance for Mathematical analysis● Research Division for Advanced Disaster Prevention
on cities● Research Group for Advanced Energy Conversion● Statistical Science Research Division

The Open Innovation Projects● The Kao

Kirei Future Open Innovation Project● Research ＆ Development Platform of Functional

Green Building Materials

2023.8.1

Campus Map

Ｔｏｋｙｏ University of Science

Oshamambe Campus

Ｔｏｋｙｏ University of Science

Noda Campus

Ｔｏｋｙｏ University of Science

Katsushika Campus
Ｔｏｋｙｏ University of Science

Kagurazaka Campus

Tokyo University of Science37Tokyo University of Science
Research Support Division■ Noda Campus

2641 Yamazaki, Noda-shi, Chiba-ken, 278-8510 JAPAN■ Kagurazaka Campus■ Katsushika Campus

1-3 Kagurazaka, Shinjuku-ku, Tokyo, 162-8601 JAPAN[TEL] +81-4-7122-9151 [FAX] +81-4-7123-9763 [URL] https://rist.tus.ac.jp/en/

6-3-1, Niijuku, Katsushika-ku, Tokyo, 125-8585 JAPANTokyo University of Science

2023/2024

RIST creates new directions in science and technology achievable“Only at TUS”.

2,265