Vol.3 No.3 2008

子牛の免疫の特徴と感染症
Character of the immunity and infectious disease in calf

第３巻３号
２
０
０
８

大 塚 浩 通Hiromichi Ohtsuka

Character of the immunity and infectious disease in calf

3.50

72'>/'<;%198õÿ·þJ\õÓ{Aõ*B-«Ì&*+./!21-2 æà¬Òa%Æ&-.9û.0!,'
N´®_0Ë#BI6<&+O'!É!($)&"
ÅPOevotw_ÇFDNÖåC[FOO7N<8[K67-HO(NC]A[W4MLO\I6["AYN!@OA\F,y´®N

2LêÚ;ð=TY\[K67O;}8#MòC[µ§EFKBI´ñ_ÁåC[&ãO­ËJ5["E@J@\YOêÚ_RIC[

'!½GNXZ>#_µ§C[&½GãO'

FUN!
(Öåý±NÅNØ._SC[)

K67-HEFNXGII²7;zÇA\I@K;ÅOOã_ºU[FUOéòÜªK

6["

UNO3;MÕJ5Z!

A\[":NØ.;SA\!ÑCNØ.ù

JP!@\Y6=H:N¥CA\FO(OOevotw_ÐBFÅP´?ãVºOùJ!Öå±OÅN96I^GI6[O=êÚNV::ZN=6FU!ÈNPØ.ù

(PLOACJ5]7:"¼V°=:Y÷Y

OOevotw;ÅOO3_íBI\I6[OP!Oevotw_DQBI6M

6[X7N¿A\[@KA85["

6@KJ5[;!E\N8IÊëO3N¤1!ONC[«;áT!Ø.ùNP

96IÔWMP_ö7!³ùOî3#@

OevotwxOU$MO_BÍ;ï

ø3;äÓN:R!

¾BI9Z!ÅOO3OäÕN~¢BI["AYN+O3_Ã[4½GW3½G

6[@K;NY:NA\HH5["SF!Ø.

âOãV!6ÝóJÖåC["Öå±!ÅOèÎPÅOOäÕO"N9>[OOÊëO3N^[½G¦PØ.:YÐãO}"J5GI!b.#|äNPU$M

A\[´ñ_ØUKC[OãBÍ_ZVB

Wì;ÅOOgikqOäÕN~¢BI6

M;Y!êI²_ÄC["}E!4½GW["K¸JP!ÅOOO,úKêÚO6

3½GMLO+O3_ö7½G¦PØ.

ÚNH6I£:M;Y¹ÀBF6"_BIÐA\[falbawOÂ¨W´®

BI6[@K;?Y\

OH`_Ï>IãB!+O(_Ä*C["TÓOO½G3PäÓN:RI^G!72'>/*+,-"OgikqOK#3NP!åñQOß

I6[VOO!ôåSJOOgikqOä/B_0ËB!?®ñNòBI5©;7!

Õ!Ø.OèÎ!$'M´®KOçÞNXGI

EO?®ñ_BIÙYOß/N<8[!K×üNOgikq;äÕC[@KKM["

67õ<=.HO)<;5["¯¾JP!?®
ñ;åñNß/BFÛ»OO(KBI!=!#6=%4:"åBOñ-QOß/NXGI!pdvn`%h

+OO}XJ5[ñãOP3½G;

W³ù!mjrsucs%½GNX[;,yö7´ñÁåNX[O¶J5["3½GK#M?®ñOµ§&ÊëO';ÄA\!É

4½GP¡N´®K7C[@KNXGIO― 111 ―

Journal of the Japanese Society for Clinical Infectious Disease
in Farm Animals Vol.3 No.3 2008

子牛の免疫の特徴と感染症

=^Õ@"-Ë\NTcMOÀ¸J+/+I

NNüM41Hbdq}I<6êè@O@[À¸irj$^ÓFH1[CU!Ë

[VNN!b8Àù6Å8LFHO1L1N\Nÿ/ø6-1RKü.Nùb£JJ>

6Z5ZW@1qI0["

HfmI0["ü.MO@Þ?YNË\I0F
HV!RÖ¾JG×@[£Â6+Ì@["ü.

!(+$#),%'*&"

NË\TcMO¼.<JMFCÀ¸6+Ì>!

0Ñ¢NÑ¨OÀ¸SüYJNþï6`1C,ôN$î^í@[JBNÀ¸M/@[b

UM!SüYN¤6L1SSäü@["äü=6ü?H©ÿO^¥;@";NX2LË

@[J4EMbË\6SüYMM=\[;J\TcNÀ¸^$î:ÆÀ¸J½P!B\^µ

MLZ!H]WQWLKMñF>CSüY^v

7@[;Ñ±^Üj$î:ÆÀ¸'MHC(

ð>L6Y!bË\OñF>CSüYNÀ¸

J12"MHC À¸MO!ü.CNRJ_KN

ù^¤>H18;JML["È÷5Y¬!M$îM+Ì@[c|h.J-Ë\!vcp`$

FFC/Ë\À¸irj$^Nº>H1L1

gWàêË\LKXNË\M>5+Ì>L1"¯Ë\O!)Ö¾*J)RÖ¾*^G×=A!

c|hJ60["

ûìLÖ¾Ë\OÁ³>L1X2M/}n§/Ë\irj$OÀ¸srkm6 MHC Z
ÑM¶Æ>CVN^G×@["-Ë\Okù^úã=A!W6H/Ë\O#òM?>H!
Ab=^C@"

NÀ¸JO@[J7M!;N MHC class!

¬!IN/Ë\NúãO!l%Wý%6?

^mi>HÀ¸srkm^ÝZÉT!/Ë\>ÐUùt~y6Îü=\ÐU[J!B\NÏ´ùMXFHÝZÉ_DÀ¸srkmM

ÄO¹1>*9["PM!¬!Ns6/Ë:>CÀ.^Îü@["À.OB7Njnc\£JN¹1^VCY>!År?YNb£JÙLKÀ¸^G×>!¶Æ@[>7^ÓG"À

N¹çJ8ÀoN6MGL6FH18JÃ3.O!À¸^Á³@[wea~NX2LYI0

Y\H1["BM!gr¢M¬!6â>H>[6!À¸BNY^Z@[ÍiOL1"À.

S2JñF>CNÍiMO!ba~h6Ë\M¡üI7L1X[CU!/Ë\N%«NV)&OüNb

2M@[!Ë®M¶Æ>HL·§Nvð^ÅU

8ÀùMV­@["YM/@[bO6Û8L[![.N>7^å9[!LK6ª:Y\["

äü4¿NÑ¨IO!/Ë\NZ£JD9-Ë\6ÍZä@À.O,Þp0Z!À¸^G

IL8À.NÎüJoV61">5>¬!IN

×>H5YøD²>HÎü=\[J1]\H/Ë\NZ£JOäü¿5Yæ#MÅSZ!

1["5ì!ñF>CYWU¸.MÀ.6¶

uE¢5Yùúã6¥;[ÊSIN2>*9!

Æ>!L·§6eNG1CñFÚ^Á³@[;\O¬!NN2J&Ò@[J13["õ+M

N6!bfhlxNnj$I0["¨6ñOÇdtÞÑ¨Näü¿N^é·L·§uozF^ß9[5YNÀ¸'U¸.(MOh#$f{ö^Õ>H1["äü¿5Y!/

LVN60FH!#M¶Æ@[À.O LZ!

4XP-Ë\6æ#M(>H4Z!;NÔ¢BNøO+3¼êMV¦QJ=\H1[";

M41HbË\Núã6óT!üa?^

NX2L.ùbMXFHb=@[ëÆÓ@[êI!'°@[SüYM/>HNAb

MO!À.NnXZÙ6ájI0FH!Å1À^úã=A[9I0[JÃ3Y\[".6Ó=\HV!ü.6À¸M/>HÅ1
Á³Jo^ÓGJO»YL1"_ùNKùØ
日本家畜臨床感染症研究会誌
３巻３号 2008― 112 ―

Character of the immunity and infectious disease in calfYÏóQÓ-Y%?LR!3¸;åíQ1,+
Ó_áW]":!GÇQ©3¸;R!ì
6XQLR1,+ÓPX¡T·L@Ñ«y|q¢ñPë¹B]"©3¸;R!âË
QB*Y;`¸;Q(ÎON!pmwxz
fx$¸;IQ¸;ÒºJ_¿IK6]Mµ8[^K6]"ÅÔ¸;!NK 3¸;!3¸;ON;ÀäBM!BQRªYç°º
J¡Sâ=±BP¦WKÈKL5]Mµ8[$%"()#&'"()!
3¸;PR!ug{sa$jON_Ú[^K6]"

B]hboeb|_¼ÜAK§Y6_ÊMBÆLQ­AO"Ú_8¿AFBiknv]*_FÿB]!³íQ¼Ü_êØAK_(!B&acquired immunity')5]6

Ú6ÁPZ]=±*&_êØB]!cbzk

R(ùB&adaptive immunity')M¯Tâ¸;!ÃS¸;YÕ¸;_'B]!M

QPîA!í1C_ñ×Pë¹B]ÅÔ¸;Y

67&;5]"?^[Q&R!D_ð7

©3¸;¨_(>B5]6RàúB#Q3¸;P7ð@^K6]"MR CD&innate immunity')MX¯T"B;

0³¬_)®B]tzq$3¸;L5\!R

O=!B&QôAK6]GÇQBö

b|l$sd{|&IFN'!Yb|l${b³Ú_¶=¿B]FWPR!."øOB

f|&IL'!._J=] Th&3tzq$'-¸ü&_¶=¿B]?M;0KL5\!í;!R IL!0!1!-,!-/ON_J=] Th.

:[Q³¬/Ü6MÝAK6]%?LQB¸;;EQ&_FAK6]"VFQ¸;üP©3¸;;<2Pë¹B]?MR!Ü

_»Bý<_B]3¸;Rfx$3¸;M¯S

íQ=±*P96KE²L5]Mµ8[^]"CD2³¬_)®AK6]"?^[3¸;R¸©3¸;;GÇQBiknvP96KÈ

;1CP3 cell Receptor&T4R'M67³

KOD_ðIK6]¾_æè@D]"@^K6]*UÇRroYuckP,UK©3¸;;!?Q3cR PR}~MQ.ÂPQ3cR

Ù;ì=ë¹B]"ò;5\!"PGQPR;ë¹A!3¸;RNH[:Q3cR _8EB

ì6"© T ¸;ÙR!IFN!g Y IL!0!IL]"ÓQ CD0*3¸;Y CD2*3¸;R!-.M6IFhboeb|_¼ÜB]&O;¶

3cR}~_8EB]}~©3¸;P7P@^!

6"ß8C³¬/Ü6;Ö$B]%?P96K!

ÛÇQ@ÑñLRï57;?Q}~©3¸;L©3¸;;BiknvQÚPû·N

5\!©3¸;RÐÙL5]"=þAK6]XQMµ8[^]"VF!

¬ÄHí_8EB]¸;MAKõ

GQPR TcR}~_´ÛAF3¸;;£©3¸;;GQPì=ë¹B]?MR!£ããPKÛÉA!@Ñ«!y|qÞYTéONPQÛÉME^PMXO7}~©3¸;Q³¬73B]QPîAK!TCR_EB]

*PX¤AK6]XQMµ8[^!©3¸;R!ó¥ÌON£ãPK7B]

3¸;Q&MAK>BM67>LQ&&ÚX½÷@^K6]"+P!©3¸

G>LO=!!BPîAKX9ÍøOD;R!ÛÇP96KR@Ñ«Yy|qÞP!y_ð7&ÚX5]"|q¢Q#Q-%1+A:ë¹AO6;!-4― 113 ―

Journal of the Japanese Society for Clinical Infectious Disease
in Farm Animals Vol.3 No.3 2008

子牛の免疫の特徴と感染症!(-/*)'"

A¥æE{VK7dzA)S"Õê(«S·Fê½E-*@!9cFgl^`Wo

F¾FW}ßøGyj!1.AGD*4BE

Î!8cF¸YxÎ/Âx5T@*SÌDHÓKmt6@!¾FìÛFBê_RVÔÁÎA)R!4F&?FHÎGD5TS4B/

6;ãê¾FhV7SJ0A)S"4TE

õ*"B.1!¸YxÎ¾GìÛVBÛ6

,@KMÅFÃªGÕê¾FöqVÚZ5

O71!ËöÈA)SB5TS"¸YxÎ¾

9!:F«FW}]^ahFè'V¨ú59SFW}>E6@G)LRO¶5T@*D

NFB²,QTS"7½F§zGù¾H.R*NFF!ôHÎEDJ@kocaÊC

AD1!NFå)FËEP>@NBê7S;/t>@*S4B/Ç5T@*S"L;¸Yx

M!¾F¦®hF;MEKMîFNFÂÎ¾FW}]^ahF4$B6@!gl^`fhVÒÉ59S4BGÔdA)S"WoÎEDJ@UÙ¥kocæ/ØD*4B/3QT!D.ANpq(ºP/ØD*"Ü

!+,#0,&$%."

Ö6;P+Epq(ºPG=TW}/E-*y9E-2SiÛG!W}>F*5/@Ôdç/Ç¹5T!4FºPF*ÿEP>@§zABê7SB¿UT/=A!4E×9F

Q.FW}/F*VK7 >ç/)S"`p/#[5TS4B/õ*"×9GÕês³

IL!&GkocFKuVòä7S\WbYW

F¾FW}]^ahF±!E-*@û0D]oA)S"IL!&Fm_f`#B5TS CD&'G

VÄ>@*S4BGw*D*"ùêE¯ç6;(ºPFGXEB©7Sm_f`#§FQvVÏ2@*D.>;¾G!Õê«!

A)R!UÙ¥pq(ºPæG CD&'eçkB

5ïùAFêJFQvVÏ2S;M!:FRË*éFñVÄ?"5QE!¸YxÎE-2¬GêöVvÄ7SE);Rû0D\üBDS"SË¾Û­¢$WCS%FÛrAG!Õê

×9GÕê(«F¾FW}çV21;ME!

Å.QÄó-EUÙ¥pq£(ºPæ/ØD*EÞEûÃD]VÄ>@*S"4TLAN

4BNVQ.E5T@*S"asE-*@p

w5T@*SP+E!×9FèKG½ÆONq£(ºP>E\üF)SÝµ!à:6;Fê

Fö&EP>@õØuD>@*S":F;M!

JIF°¤<2AD1!íV"âB6;3¾FW}>V´MS;ME!ÕgS<2È

W}ºPFBýNr1DS>ç/)S"\WF´*×9!4EW}[nekoFõ*×9V

bYWoF½ê>/´1!NK b»cVÄ?B`,S4BE#[/ÑLS4BN)S"¡<G!

5TSpq(ºPFUÙ¥"F*æG!¸Yx

×9"EGW}[nekosENjZbdXÎFW}/>E-*@ØD.Q8r{6@koOglioE,!\WbYWoONF*SNFBÇ¹5T!¸YxÎ¾F"ANA¥DCNõ1FW}JÈ/LT@-R!

WCS FE-*@@~Oi/LB6O7*

ãê¾E÷6@W}çVN;Q74B/À

h^B6@!W}-D>*EPS%6O,5T@*S"6.6NFê½6;×9Fè@FºK/oÈA)>@N!ëÍ7S¾F×9FðF?þV0;6O7*4B/3Q

TS"

Ð>N²nE:TSJ0A)R!Ë¾AGÜFP+E¸YxÎ¾GôHÎEDJ@×9FÐk/*6O71!×9ëÍ«F¥>ç/)S/!,@"W}[nekop/*ÿA)S4BN6H6

4+F¥0!;áUFNF|fIoON

H¼5TS"×9EPS¾FW}çG!

F*)S*G´½ÆDCN!Õê(«FUÙ¥

N¾BNE¦®<.Q4:!èl7S»A)S"

W}>/t>@*S

日本家畜臨床感染症研究会誌
３巻３号 2008― 114 ―

Character of the immunity and infectious disease in calf+DI[

v>H27VÃ£IlÝJØì´*Ñ

5JõCI½¨Hÿ:C8ò´HDì:R;/"Ã£IlÝ4@Y[VY7DJZ6!d4ü¿;V"ÜI@

AI/HSVðE¸1TWC/V>P!

Y&js\%'ZâÐ:C!@Y&ìþ<'

Ù>I¢c<d4]$H9WV8E4ý/"·H?UºMG/·°Hÿ:CJ![¨OÊZý6OÙ>J!Øì-´IÃ£IÜ

8:G/"/YK!¤üI¬ZEAC/V":

<I½¨IûàZD5V?7iç;V^

3:!T3IkaD+<½¨ø4T:>U!

QÆAC2U!S£4Àì;VÙ>4ß>éP

I°è½¨4ð#ûà;VE!ÜI@Y

HR;V1D!Ã£IÜ<HÚ$H½

js\%4âÐZÎ7!@YI7è4uå:¨40):C/6":3:!(D.VÃ£I

C!@Y&ìþ<'HGìO4â?:C6V"

Å}¥JÉôv>Eæ¶v>4.U!+BI

8I·°Hÿ:CJ![v>UVIRÇHJ6~è4G/"9THè½¨ZBÛ:S0E:ClÝZD;V"

54

5JD

8U!I°

²$IÃ£IÜ#¡ÏAH²þ»4.V8E+[E+<½¨HJù³Hã/ª4.

J!Ã£I+<½¨øI|ÆH#5G¦Z

U!y0:>+<½¨ø4[½WIèÆB"Ã£Ih±D.Vì>.V/J"f>Zb9:C/V"+<½¨4ü¿:G7WK+

J!Ü<I½¨HEACQh±D.U!

[Jè=<!ìþ4zðèEGV">IÜI14J+<½¨øH#5G¦Z

úáÕD.V£J,/ÜZÆ@!ï1MG

ÆAC/V"½¨øITJlÝIDì°6Ü¡ÏZ:C/C/V4!:H(DJìI~BD.V"ÀèZÖÄ:>Ånî­HSVÅhkH&
3WV>PH+<½¨ø4R:R;/"Ã
£I[AIëßHJy0:>`f¨I|!8.)*+,#502%91"
Eí;VFKRÜGFIJ![

Æ4HgD.X0"

bdgo4A;V¼òñE/1V"G3D
QÜHJ[½WI,)3T-)(4ÒMU!

!/:6$'(8.74&%-3"·þI,)(4+DÀì9WV¼#I[lÝHJe$°4.VQII!¤.;V

D.V"+H.V[bdgoJ!þH`µ

IJ+<½¨ø4TW!+@YHfp%c

GQIZ_©:!EÿH`G{OR;ö3T

4ÂV8ED.V"[bdgoIé,H.

þZÌVS0HE;V"

Vv>3Tm>H37CIÃ£HEAC!+

+<HJ*))*²EQ9WVX#G+<½¨<½¨øZëßH|Æ;V8E4[LHH

40Ó:C!+<lv%rZ¬é:C/V"#

gD.U!Ã£IlÝJ_it`%IÜ\!

MPJìþHEAC:QGI°èIG/0Ó«

hI¡ÏJp!½¨øIT!ÞGdhu

I½¨D!ìþ8HHgGmtqwOÊ!kdGF!ý6I3D[bdgoIé×Z÷

enwZ¹é:>U!ÜHQYAC/V";V¼#Isdal[ae%D.V"M>!Ã

8I+<lv%rIü¿HSAC!I°èI½£IlHÿ;V·¨¾IjfJëßG½¨ø¨R^]td4â?:CQCD2Gûà4i1

LINZ'9=VAèQ.U!lIÍ

TWC/V".ß!+<½¨HJI°èIZ/

rRI!ZÔPHk:CÈo;VHg4.V"½¨&ó§¨'!Ë/I°èI.V½¨&x§

s1K#+¨GFJ+<Hß¿:C/V½¨D¨'E=t¯¨E/0Á0«I+<½¨ø4ê

.VQII!lÝZDÝ:>²þ3T#qH

NB/C/V"®Ø9WVE°Z#+¨èlÝEä%9W― 115 ―

Journal of the Japanese Society for Clinical Infectious Disease
in Farm Animals Vol.3 No.3 2008

子牛の免疫の特徴と感染症

S7CNÏE4E-"Ëã®G¼¡BH!âÕ

F,=SNGG!YXydæFP>AQM

E"4µ¥íG&þ22TSNGG!Ñ¯82H9="4BHµ¥íGÀ2Ë

8H&9A-E-=M"4µ¥í29ú

[E4ES7CNVð8TS"<G=MF'Á

9O;-"2FG6áE2C&B,>=R!

'Fµ¥EDGæÒU;Ò;Sxd^2³4

÷X6JG*ED¼¡GÑ8`CG¨F

ES"7GP.E'Á'Eµ¥æUVð9A

C§´2ã:SC!PÑG6àE2"F^±¥·N»X8TS7CN,S2!âÕµ¥í

79A"4µ¥í2C&CER!]ÒU;UÀ;S=MFozkX[!o{kX[ä·Ò;S7CFNES"ÔÌ9=2!¼¡G]G,WEDN°2õB3SJKG?B,ÒU²¹;SÔBQ8I1RGRùBE4

S"L=!`^bcYsÒHÅFB<F;ã;¼¡GÑ8`F?-ANÈRÔ6SK3B,S"

S2!;ãF¶9AH¦!UÿØFôÍ8TS

]GP.EdizdBH`ygeyGºG2=B,S"919`^bcYsH¡G"ã2ïÚ8T!á#pyu|Gºã2$;S"4FÕ¸9A-S?ãDB,R!æFP>A`ygeyHQµLG8UZß;Spyux|l|B,R!á#pyu|H¤çGá#UïÚ;20DFô9AN-F(åEJKB,S1F?

S¼G?B,S"L=!`ygeyH¤ç-AH©Ó;S@YN,S1N9TE-"

GE82³LSC8T!êE¦Î

Fô9Ao{_ws½$Wqi#bd%UU1¢-+æ`CA«`UÀ??ãDGæH¬;S7CNüQTA0R!]FPSdizd

ÉFVM;SK3B,S2!`^bcYsÒO

H¤çBG+µLG£8U¢4Zß;SNø"¥EDH¼¡G"4GÕ¸?ãDB,R!

GC²/QTS"¤çBE;S CD(!CDÛBHnjY)C->=}~+µLÞG­ÏFH!]ÒF

U5bªæÒFý@5A-S"¼¡G5bPS®)'E¤çG$áÊGW2,S"J!

ªæÒFEaB3SP.E¼¡G]ÒUV

"FH*µLOÔÌ9=+µL2ò4ñ

M;SEQ!¼¡GàUÉ¾9A¼¡Uÿ¸9!"4JG±óºãOQàUïÚ9ØC9=éJKU©/;S7CNB,S"

A-S"]ÒU;Ò9=¼¡BH"ì×G
ft#c2ø34!+µLGE2%ö;S8àH³-"Ü'FHËã®F:]U;Ò
9A!Â_9=¼¡GOÐ+µLGÝUÃ9A-S"]ÒU;Ò9A-Sè®G+µLÞ
2$ûBÝ9A-S"æà]ÒF0-AH!æ?ãDGFP>AQ.2

ES¿Nî&B3S"ø

"¥H¥ó43ë!Z|ji]b|UFT9A-S"Z|ji]b|H¢`FÒàaXi\X|GIËUï9!"JGÒDÄGE>UïÚ;SCCNF!êÙGbvh^ÒÖUÆ;S"YXydà]ÒF0-AH!NK µL!
CD)&+µLOr^{mV#c2ÇSCE>A!YXydOYXydGæ9=µLGÍ\
日本家畜臨床感染症研究会誌
３巻３号 2008― 116 ―

¥O^xoidqxcYsæCharacter of the immunity and infectious disease in calf

I:}~ìE\ìD35?!5G5Gº¤Ä!,+&)-$.*"}~ìS\ì5:ËL!tû}Eu8.

SMw7P3A/)P"º¤ÄFAU@Â¤

N\t/dàgC³2@F![{S\ì7P3

E*ó5:}~ìD35?·/)PKEE!

A/11)P"[{FÞ;\þ7P3A/11!

[UD)PðÅ¤E4ú~SK:N7Zú/ëTCBEü_L!º¤ÄE(9!kX\)PA*+g[XSY×5C2QGCNC*"_%ZelbjYfdEÙÌN/âÏ4QP"

}sDu8/)P:JD}~L[{E\þ/5.5ûCdE)P³2@Fpê«(Âm/

1*¥@F!EÐttû/ßg@C*:JD}7Pg[X/½1!N.E[^i[/

D[{E\þ7P¯úK½1CP"5:/=

RPArzZED}DM=?W®[{E\?!}~Eæ?Dº¤ÄSðy7PA[{E\ìSxoD7PKEA¼,NQP"

þÓDv·Cº¤ÄE(9ÎS

17P¯ú

rzÂmS»û5?*PEFUc`É@)O!

/½1CP"4ú¤E*óArzZ[]dEû

3QNEÂmFPgSV_hW%A5?Z7ãdFVÔ[{S\ì49P¯úS6*D

P"SD¡'@E(ÂmEt|O/a%XE½17P"Ó@)PX#tûË@Ex{dF!â
6CrzZ[]dEûãdSé1")å5:!#('%"/!Eë~!SDrE\:F0QfDFC

@EþÈD-*?!%ìE\þF]2P*SÛCKE@!7urE\:Aë~ZCx

3AEä|C*u8@)P"%ìE\ìS¼{gEF!tûE¿¨ûLç+EÆ7Pî@!%`þfAþ2E%n¶AEZEqÒD^ðD60Cw¢Sw,P"X¦Sã7PH0@)P"3QI@Â¤D3

Dx{SXáDn/5?*:ËF!Xá

7Põ:Cº¤ÄE\L!rzZS½JPmE´¨ÐSÁô5ÊJ!>*DFX5:JDkX\lD7P­F!þÈ²ïD-?&qA´¨Ð.NCPÐ{}E}@tû*?ÙÃEQfE2U@!)P*F¥U@

7P3ADCP"Ð#©d-E)PËEp/3=?*PE.SqD5C*II÷JN

ê«(ÂmùFÒ.GDD<@øp7P"I:!

Q?0:M+DK6NQP"µJGCûCdD)Ptû@F!
&ÂöE

WoEM+DÐtEh~DeT;>s@

2§'ACP3AFÝ=EÑÙ@)P/!3E

F!@E2B/h~5L71!$,8W®

M+C2§E@Fpê« T Âmù/D<@%ìS\ì5L7*"$FþÈ²ï@\þ)P"ËEÐ{klDu8/)Pï¾DF!

5?*P%ìS):.Kc°úK%cAR

èGCØcS\ì5?*C1?KrzÂmE

NEM+D,,?5I*!yþEIEDÚ
S?*:M+DK¼,NQP"°v`þfAg~#*óS±549PKEAÕÀ4QP"[{E1\7P¥@F!5G5Gx{d

RND@ÖöEtû#Ðtò/B+@)P

E2§E/Ç®4QP"[{E1\7P¥E.!QfÖöEFºú/BEM+Cò@)

D35?!rzZE¹îStGDkX\_%

PE.SK+uLÆ7P3AKaz.K5Q

ZelbjYfdSÿ£GDÙÌ7P3A/1

C*"u8/\þ5?*P²ï@EñjSý*KEE!kX\lE·

S½JPECN"Ü

Db5!K+uLoD<i=?&')7PÖöErzZS½JPaz/)O!H

P*F&¥'/BEM+CòCE.S¬í!CÐtE}@HýDSûC49PH0

7P3A/u8ªEÍ¸DCPKEA¼,P"@)P"― 117 ―

Journal of the Japanese Society for Clinical Infectious Disease
in Farm Animals Vol.3 No.3 2008

子牛の免疫の特徴と感染症

Character of the immunity and infectious disease in calf

Hiromichi Ohtsuka
Kitasato University"')!%!Higashi&'bancho! Towada! Aomori! $'(!+*&+!Japan#

日本家畜臨床感染症研究会誌
３巻３号 2008― 118 ―