SAFETY DATA SHEETThis safety data sheet complies with the requirements of:
JIS Z 7253:2019
Revision date 10-Jul-2024
Revision Number 16

1. Identification
Product Name

DOP

Safety data sheet number

CGE-A-001

Registration Number(s)CGE-A-001

Details of the supplier of the safety data sheet
Manufacturer
CG ESTER CORPORATION
Shin Otemachi Bldg.,2-1,Otemachi 2-Chome,Chiyoda-ku,Tokyo 100-8105 Japan
TEL:+81-3-5203-2860 Fax:+81-5203-2864
Emergency telephone number+81-3-5203-2860

Recommended use of the chemical and restrictions on use
Recommended Use
Restrictions on use

Plasticizer and solvent for various resins
Please do not use for other than recommended use.

2. Hazard(s) identification
GHS Classification
Acute toxicity - Oral
Acute toxicity - Dermal
Acute toxicity - Inhalation (Gases)
Acute toxicity - Inhalation (Vapors)
Acute toxicity - Inhalation (Dusts/Mists)
Skin corrosion/irritation
Serious eye damage/eye irritation
Respiratory sensitization
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
Specific target organ toxicity (single exposure)Specific target organ toxicity (repeated exposure)
Aspiration hazard
Acute aquatic toxicity
Chronic aquatic toxicity
Ozone

Not classified
Not classified
Classification not applicable
Classification not possible
Not classified
Not classified
Category 2B
Classification not possible
Not classified
Not classified
Not classified
Classification not possible
Not classified
Classification not possible
Not classified
Not classified
Classification not possible

GHS label elements
Does not apply

Signal word
Hazard statements
Causes eye irritation

Warning

Precautionary statementsPage

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Prevention• Wash face, hands and any exposed skin thoroughly after handlingResponse• Not applicable• IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing• If eye irritation persists: Get medical advice/attention
Storage• Not applicable
Disposal• Not applicable
Other hazards
No information available.

3. Composition/information on Ingredients
Pure substance/mixture

Substance

Common name

Dioctyl phthalate

Chemical formulaC6H4(COOCH2CH(C2H5)C4H9)2

Chemical name

CAS No.

Weight-%1,2-Benzenedicarboxylic acid bis(2-ethylhexyl)
ester

117-81-7

>=99

ENCS
Inventory
Existing

ENCS
Number(3)-1307

ISHL
Inventory
Existing

ISHL No.
(3)-1307

4. First-aid measures
General advice

Show this safety data sheet to the doctor in attendance.

In case of inhalation

Move to a place with fresh air and rest in a comfortable posture. If you feel unwell, contact
your doctor.

In case of skin contact

Wash off immediately with soap and plenty of water. Consult a physician if necessary.

In case of eye contact

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing. Keep eye wide open while rinsing. Get medical
attention if irritation develops and persists.

In case of ingestion

Rinse mouth. Do NOT induce vomiting. Call a physician.

Most important symptoms/effects,
acute and delayed

No information available.

Note to physicians

Treat symptomatically.

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Suitable Extinguishing MediaDry chemical or CO2. Foam. Dry sand.

Unsuitable extinguishing media

Do not scatter spilled material with high pressure water streams.

Specific hazards arising from thechemicalIncomplete combustion may generate toxic carbon monoxide gas.

10-Jul-2024

Hazardous combustion products Carbon monoxide. Carbon dioxide (CO2).
Special Extinguishing Media
Large Fire-

If it cannot be moved, sprinkle water on the container and its surroundings to cool it.
Firefighters should wear self-contained breathing apparatus and full firefighting turnout
gear. Use personal protection equipment.

6. Accidental release measures
Personal precautions, protective
equipment and emergency
procedures

Avoid contact with skin, eyes or clothing. Use personal protective equipment as required.
Do not touch or walk in the leak.

For emergency responders

Use personal protection recommended in Section 8.

Environmental precautions

See Section 12 for additional Ecological Information.

Methods for containment

Prevent further leakage or spillage if safe to do so.

Methods for cleaning up

For a small spill, collect the spill by adsorbing it with absorbent (sawdust,soil, sand, or
waste cloth) and wipe the residue well with waste cloth anddust cloths. Dike to collect large
liquid spills. Use a non-combustible material like vermiculite, sand or earth to soak up the
product and place into a container for later disposal.

Prevention of secondary hazards

Clean contaminated objects and areas thoroughly observing environmental regulations.

Other information

Refer to protective measures listed in Sections 7 and 8.

7. Handling and Storage
Handling
Local and General Ventilation

Perform local exhaust and general ventilation in item 8.

Advice on safe handling

Handle in accordance with good industrial hygiene and safety practice.

Prevents Handling of Incompatible See Section 10, Reactivity, Conditions to Avoid, Dangerous Goods to Touch.
Substances or Mixtures
Hygiene Measures

Avoid contact with skin, eyes or clothing.

Storage
Storage Conditions

Keep container tightly closed in a dry and well-ventilated place.

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8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Exposure guidelines
Chemical name

Japan Society of Occupational
Health

1,2-Benzenedicarboxylic acidbis(2-ethylhexyl) ester
117-81-7

TWA: 5 mg/m3

Biological occupational exposure
limitsISHL Working Environmental
Evaluation Standards Administrative Control Levels-

ACGIH TLVTWA: 0.1 mg/m3
Sk*This product, as supplied, does not contain any hazardous materials with biological limits
established by the region specific regulatory bodies

Chemical name
1,2-Benzenedicarboxylic acid bis(2-ethylhexyl)
ester
117-81-7

Japan Society of Occupational Health-Engineering controls

Showers
Eyewash stations
Ventilation systems.

Environmental exposure controls

No information available.

ACGIH
-

Personal protective equipment
Respiratory protection

Use gas masks, air masks, air respirators, etc. for organic gas as needed.

Hand protection

Impervious gloves.

Eye/face protection

Wear safety glasses with side shields (or goggles).

Skin and body protection

Antistatic long-sleeve protective clothes and shoes.

9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
Appearance
Physical state
Color
Odor
Property
Melting point / freezing point
Initial boiling point and boilingrange
Flammability

Liquidcolorless
Almost odorless
Remarks

Values-50 °C / -58.0 °F
386 °C / 726.8 °F

When heated to high temperatures,combustible gas is produced bydecomposition.
Upper/lower flammability or explosive limits
Upper flammability or explosive No data available
limitsLower flammability or explosive 0.1 vol%Page

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limitsFlash point
Evaporation rate
Autoignition temperature
Decomposition temperature
pH
Viscosity
Kinematic viscosity
Dynamic viscosity
Water solubility
Solubility(ies)
Partition Coefficient(n-octanol/water)
Vapor pressure
Density and/or relative density
Relative density
Liquid Density
Bulk density
Relative vapor density
Particle characteristics
Particle Size
Particle Size Distribution

218 °C / 424.4
No data available
400 °C / 752.0
No data available
No data available

10-Jul-2024°F°F

77 mPa s
No data available
Insoluble in water 0.003 mg/L
Soluble in Ether Alcohol
7.60@ 20 °C

160 Pa@ 200 °C

0.986
No data available
No data available
13.46@ 20 °C@ 20 °C

Other information

10. STABILITY AND REACTIVITY
Reactivity

Stable.

Chemical stability

Stable under normal conditions.

Possibility of hazardous reactions

None under normal processing.

Conditions to avoid

Keep away from open flames, hot surfaces and sources of ignition.

Incompatible materials

Strong oxidizing agents. Strong bases. Strong acids.

Hazardous decomposition products Carbon monoxide. Carbon dioxide (CO2).
Explosion data
Sensitivity to static discharge
No information available.
Sensitivity to mechanical impact No information available.

11. TOXICOLOGICAL INFORMATION
Acute toxicity
Numerical measures of toxicity
No information available

Chemical name
1,2-Benzenedicarboxylic acidbis(2-ethylhexyl) ester
Abbreviations and acronyms- Product Information

Oral LD50= 30 g/kg ( Rat )Dermal LD50
= 25 g/kg ( Rabbit )Page

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Inhalation LC50
> 10620 mg/m3 ( Rat ) 4 h

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Rat: Rat
Rabbit: Rabbit
Symptoms

May cause redness and tearing of the eyes.

Product Information
Ingestion

Specific test data for the substance or mixture is not available.

Inhalation

Specific test data for the substance or mixture is not available.

Skin contact

Specific test data for the substance or mixture is not available.

Eye contact

Specific test data for the substance or mixture is not available. Causes eye irritation. May
cause redness, itching, and pain.

Skin corrosion/irritation

Classification not applicable.

1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
Species
Effective dose
Results
Serious eye damage/eye irritation

Rabbit0.5 g
Mild skin irritant

Classification based on data available for ingredients. Causes eye irritation.

1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
Hazard rationale information
According to ACGIH (7th, 2001), ATSDR (2002),EHC 131 (1992)11)and EU-ARA No.42(2003), it is conceivable that DOP is not eye irritating or slightly eye irritating, and based on
the study result that DOP is slightly eye irritating, it was classified into category 2B
Respiratory or skin sensitization

1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
Hazard rationale information
Skin sensitization:According to the description in EU-RAR No. 42 (2003), DOP was notshown as skin sensitizing by test results of the “maximizing method and Buehler method
using guinea pigs.” It was conceivable that DOP is not skin sensitizing, and it was classified
as “not classified”

Germ cell mutagenicity

1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
Hazard rationale information
DOP was negative from results of mutagenicity tests with microbes (not injurious toDNA).According to CERI & NITE’s Hazards Evaluation No. 7 (2004) and ATSDR (2002),
DOP is positive in mutagenicity tests (dominant lethal tests) through generations. However,since administration routes in the tests showing positive were not appropriate and otherdominant lethal tests and micronucleus tests proved negative, it was classified as “notclassified”
Carcinogenicity
The table below indicates whether each agency has listed any ingredient as a carcinogen.

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Chemical name

Revision date

Japan

IARC

1,2-Benzenedicarboxylic acid2bis(2-ethylhexyl) ester
117-81-7
LegendIARC (International Agency for Research on Cancer)
Group 2B - Possibly Carcinogenic to Humans

10-Jul-2024

Japan - ISHL DesignatedCarcinogens

Group 2B

1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
Hazard rationale information
In 1980, it was reported that DOP administration at very high concentration to rats induced
tumors in the liver. The subsequent research revealed that the hepatic tumors occur
through a mechanism unique to rodents. Based on this, in 2000, IARC (International
Agency for Research on Cancer) modified the DOP carcinogenic classification from theconventional “2B” (possibly carcinogenic to humans) to “3” (not classifiable as tocarcinogenicity for humans) because of no carcinogenicity in humans. At the meeting in
February 2011,however, IARC decided to return DOP to “2B.” It is not because new
evidence in humans was found, but because further investigations and research areconsidered necessary for the mechanism and epidemiology of carcinogenicity in rodents.
The Japan Plasticizer Industry Association(JPIA) examined in detail the articles used as theevidence for the modification, and considered as in the past that species differences exist
in DOP carcinogenicity, and the GHS classification was established as “not classified”
Reproductive toxicity

1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
Hazard rationale information
The substance was administered to a pair of male and female mice by blending into food,and the pair mated multiple times . As a result administration of 144 mg/kg/day or more wasobserved to produce infertility and decrease the number of surviving babies of the same
pair No influence is observed on testis in testing the substance by using adult and juvenile
marmosets. From the data of rats/marmosets in the studies performed so far, it was shownthat a large species difference exists in the reproductive toxicity(including testicular toxicity)of DOP between rodents and primates, and applying the data obtained in rodents tohumans is not considered. In the past literatures of the assessment in CSTEE in EU,
assessment by CERHR in the U.S.A. and assessment by Advanced Industrial Science andTechnology of Japan, it is observed that there is any species difference. In the estimation of
acceptable level based on the data of rodents, the discussion about the above species
difference has not been reflected to the safety coefficient, and the possibility of reproductive
toxicity in humans has not been concluded yet. It has been reported in the aspect of
metabolism of DEHP that there is a species difference between rodents and humans. Thatis, after ingestion of DEHP in rodents, its free metabolite is likely to circulate in the body,
but in humans, most of the metabolites are excreted from the body quickly in the nontoxic
glucuronide form. These phenomena have been confirmed in the experimental result ofpharmacokinetics in the liver-humanized chimera mice, and the amount of exposure
estimated from the humanized PBPK model and human biomonitoring data is
incommensurably lower than the present TDI value. That is, it was concluded that the risk ismanaged appropriately. In compliance with the present manual for GHS classification, theevaluation of species difference is insufficient, it is inappropriate for DOP with vast amountsof research data to perform the evaluation in humans as the evaluation of species
differences is insufficient, and at present, it should not be classified (“not classified”).

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1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
Hazard rationale information
As described in the reproductive toxicity section, it was found from the data of the study inrats/marmosets performed so far that the pharmacokinetics of DOP is different between
rodents and primates, and it is shown that testicular toxicity does not develop in primates.
(Not classified)

Other adverse effects

No activations were observed in estrogen activation tests in vivo (uterine hypertrophy
reaction test with the ovariectomized rats).

12. ECOLOGICAL INFORMATION
Ecotoxicity

1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
Hazard rationale information
Acute: Acute toxicity has not been reported at concentrations up to water solubility (0.003mg/L).
Chronic: Classified as “not classified” because of rapid degradation and low
bioaccumulation. The NOEL observed in the toxicity study of killifish in the initial growthstage by Shioda and Wakabayashi (2000) and the Ministry of the Environment (2004d)
using the dissolution aid by the method considered appropriate is far higher than watersolubility, and the concentration is the implausible value at the DOP concentration detectedin the general aquatic environment

Persistence and degradability

Good degradability.

1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester (117-81-7)
MethodExposure time
OECD Test No. 301C: Ready
Biodegradability: Modified MITI Test (I)(TG 301 C)
Bioaccumulation

Value
BOD 69%Results
Readily biodegradable

It is no or low concentrative and does not bioaccumulate.

Component Information
Chemical name
1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester
117-81-7

Partition coefficient5.03 (*BCF=29.7)

Mobility in soil

No information available.

Hazardous to the ozone layer

Classification not possible. Based on available data, the classification criteria are not met.

Other adverse effects

No information available.

13. DISPOSAL CONSIDERATIONS
Waste from residues/unused products
Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation.

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Contaminated packaging
Dispose of in accordance with federal, state and local regulations.

14. TRANSPORT INFORMATION
IMDG

Not regulated

ADR

Not regulated

IATA

Not regulated

Japan
Special precautions

Not regulated
Make sure the container is not damaged, corroded, leaked, etc. before shipping.

15. Regulatory Information
Safety, health and environmental regulations/legislation
specific for the substance or mixture
National regulations
Pollutant Release and Transfer Register (PRTR)
The amount of the relevant substance in certain cases referenced in article 4(i)(a) or 4(i)(b) of the Enforcement Order of the Act on
Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to theManagement Thereof (PRTR Act) is calculated based on the conversion factors shown (with safety factor = 1 in cases whereconversion factor information is not available)
Chemical name**Cabinet order Metal, CN, F, etc
nameBis(2-ethylhexyl)
phthalateConversion
coefficient

Content rate %Category

100

Class I
designatedchemical
substance

Ordinance
number
1-396

Control number
355

Refer to Cabinet order name

Industrial Safety and Health Law
Harmful Substances Whose Names Are to be Indicated on the Label
Article 57-1 of ISHL, Article 18, Item 1, Item 2, Appended Table 9 and Item 3, Appended Table 3 of Order for Enforcement
Chemical name
1,2-Benzenedicarboxylic acidbis(2-ethylhexyl) ester

Ministerial OrdinanceName
Bis(2-ethylhexyl) phthalate(synonym: DEHP)

CAS No.

Content rate %117-81-7100

Implementation date

ISHL Notifiable Substances
Article 57-2 of the ISHL, Article 18-2, Item 1, Item 2, Appended Table 9 and Item 3, Appended Table 3 of Order for Enforcement
Chemical name
1,2-Benzenedicarboxylic acidbis(2-ethylhexyl) ester

Ministerial OrdinanceName
Bis(2-ethylhexyl) phthalate(synonym: DEHP)

CAS No.

Content rate %117-81-7100

Implementation dateHarmful substances requiring risk assessment
Article 57-3 of the ISHL

Industrial Safety and Health Act 【2024.4.1~】Chemical Substances Hazardous to Skin, etc.(Regulations Article 594-2

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Paragraph 1)

Chemical name

CAS No.

1,2-Benzenedicarboxylic acidbis(2-ethylhexyl) ester

117-81-7

Causing Skin
Absorption
X

Causing Skin Damage

Causing Skin Eye
DamageCausing Skin Specific
Substance

Poisonous and Deleterious Substances Control Law
Not applicable
Fire Service Law:
Flammable liquids, group 4, 4th class petroleums, hazard rank III, 6000 liters
Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (CSCL)
The table below indicates ingredients above the cut-off threshold considered as relevant which are listed
Chemical name
CAS No.
Chemical Substances Control Law
1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester
117-81-7
Priority assessment chemical substance
Act on Prevention of Marine Pollution and Maritime Disaster
Subject to the Law Regarding the Prevention of Marine Pollution and Maritime Disaster and its Ordinance, Table 1- 2; category Y
Water Pollution Control Act
Designated substance may cause adverse effects to human health or the living environment per Water Pollution Control Law
article 2 and Enforcement Order article 3-3
Waterworks (Water Supply) Act
Waterworks (Water Supply) Act article 4 water quality guidelines
Air Pollution Control Law
Hazardous air pollutants (HAPs) per Air Pollution Control Law article 2, paragraph 1, item 3 and Enforcement Order article 1
Positive List of Food Contact Materials
Specifications and standards of foods, additives, etc. 3-A-7 “In the devices or containers and packages contacting with foods containing oil or fat,the synthetic resin mainly containing polyvinyl chloride using bis(2-ethylhexyl) phthalate as a raw material should not be used as a raw material.
However, this shall not apply when processed so that bis(2-ethylhexyl) phthalate may not dissolve or leach and may not be mixed with foods.
Specifications and standards of foods, additives, etc. 4-A-6 “the synthetic resin mainly containing polyvinyl chloride using bis(2-ethylhexyl) phthalate
as a raw material should not be used as a raw material in toys.”

International Regulations
The Stockholm Convention on Persistent Organic Pollutants
The Rotterdam Convention
International Inventories
TSCA
DSL/NDSL
EINECS/ELINCS
ENCS
IECSC
KECI
AIIC

Not applicableNot applicableComplies
Complies
Complies
Complies
IncludedComplies
Complies

Legend:TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AIIC - Australian Inventory of Industrial Chemicals

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16. Other Information
Revision date
Revision Number
Revision Note

10-Jul-2024
17

Key or legend to abbreviations and acronyms used in the safety data sheet
Legend Section 8: Exposure controls/personal protection
TWA
TWA (time-weighted average)
STEL
Ceiling
Maximum limit valueSk*+
Sensitizers
LegendIMDG

International Maritime Dangerous Goods (IMDG)

IATAInternational Air Transport Association (IATA)ADRSTEL (Short Term Exposure Limit)
Skin designation

European Agreement concerning the International
Carriage of Dangerous Goods by Road

Key literature references and sources for data used to compile the SDS
Agency for Toxic Substances and Disease Registry (ATSDR)
U.S. Environmental Protection Agency ChemView Database
European Chemicals Agency
European Food Safety Authority (EFSA)
Environmental Protection Agency
Acute Exposure Guideline Level(s) (AEGL(s))
U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act
U.S. Environmental Protection Agency High Production Volume Chemicals
Food Research Journal
Hazardous Substance Database
International Uniform Chemical Information Database (IUCLID)
Japan GHS Classification
Australia National Industrial Chemicals Notification and Assessment Scheme (NICNAS)
NIOSH (National Institute for Occupational Safety and Health)National Library of Medicine's ChemID Plus (NLM CIP)
National Library of Medicine’s PubMed database (NLM PUBMED)
U.S. National Toxicology Program (NTP)New Zealand's Chemical Classification and Information Database (CCID)
Organization for Economic Co-operation and Development Environment, Health, and Safety Publications
Organization for Economic Co-operation and Development High Production Volume Chemicals Program
Organization for Economic Co-operation and Development Screening Information Data Set
World Health Organization
Disclaimer
This SDS complies with the requirements of JIS Z 7253:2019 (Japan). The information provided in this Safety Data Sheet is correct
to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a
guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or
quality specification. The information relates only to the specific material designated and may not be valid for such material used in
combination with any other materials or in any process, unless specified in the text.
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