LEISURE, INC.

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What IS LEISURE

Leisure offers

A Health Management Platform That Supports Individuals To Manage Their Own Health数

Demecal service consists of an immediate blood separation system that anyone can use anytime, anywhere and alifetime health management data service.
Health management approach should be in sync with an individual’s lifestyle.
The most innovative feature of the service is a “health management program” that is based on an individual’s
chronological history of test results.

Leisure’s goal is to be the “home doctor to 100 million people.”2

DEMECAL Service

Three Pillars ofService

Immediate blood separation device
Capability to conduct blood
analysis with ultra-small
volume of blood3

Demecal Kit has been approved by theMinistry of Health, Labor and Welfare. It is thefirst combined medical device to be approvedby the ministry.
Approval Number
22600BZX00362000(Combined medical device）
Lancet（prick finger）

Pipette（absorb blood）

Cylinder with filter（separate blood）

Sealing cap（seal separated blood）

Vial with buffering liquid（mix blood with liquid）

Band-Aid（place over wound）

Alcohol wipe（disinfect finger）

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DEMECAL’S SELFCARE PROCESSDEMECAL kit isdelivered directlyto user

User collects
blood anytime,anywhere

Blood test report
Is sent to user by
post or email

User sends theblood sample
back to laboratory

Blood sample
is measured
and analyzed
at laboratory

Self-Medication

Disease prevention

Early treatment
in hospital

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Features of DEMECAL SERVICE

6FEATURE.1

Point Blood Test Requiring Ultra-small
Volume of Blood

Today clinical blood tests are conducted in the following manner1) Doctors, nurses or clinical laboratory technicians collect blood from patients
2) Blood is centrifuged to separate plasma3) Serum is placed in a container
4) Serum is analyzed by a blood analysis equipment
This method requires approximately three vacuum tubes (10 ml) of blood
With the Demecal kit, it is possible to separate the plasma by placing 3 to 4 drops of peripheral blood into a cylinder
containing a dilution buffering solution and simply pressing a piston equipped with a special filter. This method isproprietary to Leisure, and is the only technology available worldwide that is capable of immediate plasma separationof ultra-small volume of blood at ambient temperature and pressure.

約10ml

150

0.065ml

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FEATURE.2

Point

Stability during Transportation and Highprecision Analysis

Separating the plasma immediately
after drawing blood using theimmediate plasma separation device
developed by Leisure allows thespecimen to maintain its integrity
during transportation.
Analysis is conducted by reliable
analyzers utilized in conventional
blood test centers.

Leisure’s patented technologies thatconsist of immediate plasma
separation device and ultra-small
volume quantitative blood analyses arethe foundation to ensure accuracy.

8FEATURE.3

Point

CRMLN CERTIFICATIONThe CDC (Centers for Disease Control and Prevention) is a federal
agency under the Department of Health and Human Services in the USA
that assumes a leading role in promoting health. It provides reliable
information that contributes to decisions related to health and is a key
player in developing activities targeted to disease prevention and healthpromotion.
As the effects of lipids on cardiovascular disease have become moreevident, accuracy of lipid tests has become even more important. It is,therefore, imperative to standardize lipid measurement. The CRMLN(Cholesterol Reference Method Laboratory Network) an internationalorganization set up by the guidance of the CDC has continuously
undertaken such standardization. The CRMLN is a network centeredaround the CDC which was requested by the WHO to standardize
measurement of lipids. The CRMLN has standardized laboratories
located in 10 facilities across 8 countries and is accepted as the model forinternational collaboration for clinical testing.
The CRMLN issued certificate is proof of accuracy assurance for
manufacturers of reagents and laboratories. Test results using reagents bysuch manufacturers and laboratories are deemed to be highly reliable.
Demecal’s measurement of lipids using Leisure’s immediate plasma
separation technology and ultra-small volume blood analysis method was
the first to meet international standards using ultra-small volume of blood,

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FEATURE.4

Point Laboratory Dedicated to Demecal
Demecal’s tests are conducted at a dedicated laboratory
located in Yamanashi Prefecture called “The Demecal
Healthcare Research Center” (DHRC).

DHRC is registered with the Yamanashi Prefecture as aclinical laboratory that meets the regulations establishedby the Health, Labor and Welfare Ministry (RegisteredClinical Laboratory No.16). Furthermore, DHRC has
received the highest possible grade by the Integrated
Accuracy Assurance Committee of the Japanese
Association of Medical Technologists that annually
evaluates the facility’s accuracy management.
DHRC has the capacity to handle three million specimens
per annum.
Management Company

Eil Inc,
Demecal Healthcare Research Center
855-24 Komatsu Kasugaicho Fuefuku-shi
Yamanashi JapanIMS Group
Eil, Inc. is the clinical laboratory arm of IMSGroup that operates more than 70 hospitals
and medical facilities in Northern Japan andthe Kanto Area.

衛生検査所登録番号：板橋区第４号
医療関連サービスマーク認定番号：E(7)0802130310
医薬品販売許可番号：0319030029号
高度管理医療機器販売業：4501190500022号
アメリカ血液バンク協会（AABB）認証施設

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FEATURE.5

Point

Prompt and Easy to Understand Test Reports• Test results are sent to the user’s registered address in approximately
seven business days after the user mails the blood specimen.
• If the user registers an email address, the user will receive an email with
an url link to the test results in approximately four business days.

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中表紙

TEST CATEGORIES

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TEST CATEGORIESBiochemistry
Total protein (TP)Albumin (ALB)
Asparatateaminotransferase(AST)
Alanineaminotransferase(ALT)
γ-glutamyltranspeptidase(γ-GTP)
Total cholesterol (T-Cho)
Triglyceride (TG)High density lipoprotein cholesterol (HDL-Cho)
Low density lipoprotein cholesterol ( LDL-Cho)
Blood urea nitrogen (BUN)
Creatinine（CRE）
Uric acid （UA）
Glucose （GＬＵ）
Glycosylatedhemoglobin A1c （HbA1c）

Periodontology
Actinobacillusactinomycetemcomitans(A.a)
Porphytomonasgingivalis(P.g)
Prevotellaintermedia(P.i)
Eikenellacorrodens(E.c)

Tumor Marker
Carcinoembryonicantigen (CEA)
α-fetoprotein (AFP)
Carbohydrate antigen 19-9 (CA19-9)
Carbohydrate antigen 125 (CA125)
Prostate-specific antigen (PSA)

Immunology
Ferritin
Helicobacter pylori antibody
High sensitive C-reactive protein
Anti-p53 antibody (anti-P53)
PepsinogenⅠ/Ⅱ

Viral Immunology
Human immunodeficiency virusantibody (HIV)Hepatitis C virus antibody (HCV)
Hepatitis B virus antibody (HBV)

Other
Adiponectin
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PATENTS

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PATENTS. 1

JAPANUltra-Small Volume Blood Separation System

Ultra-small volume test system（Plasma Separation Device）（Leisure Device Testing Procedure）

Patent No.：3597837

Patent No：3698696

Title：BLOOD SEPARATING DEVICE AND BLOOD

Title：BIOLOGICAL SAMPLE PREPARATION, QUANTIFICATION AND

SEPARATING METHODPRESERVATION METHOD

Table-Top Automatic Analysis Machine
Patent No：3445791
Title：METHOD, DEVICE, AND CARTRIDGE FOR
BIOCHEMICAL ANALYSISUSA
Patent No.：US6936473 B2
Title：METHOD OF PREPARING A BIOLOGICALSAMPLE FOR QUANTIFICATIONEUROPE
Patent No ：EP1221614
Title：METHOD OF PREPARING BIOLOGICALSAMPLE FOR QUANTIFICATION

15PATENTS. 2

Patent No：10-0566124

Patent No：I 247615

Title：APPARATUS FOR SEPARATING BIOLOGICALSAMPLE

Title：分離生物様品之装置及分離生物様品之方法

METHOD OF THE SAME

Patent No：１３５９２６
特許名称： APPARATUS FOR SEPARATING BIOLOGICALSAMPLEMETHOD OF THE SAME

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中表紙

Company Profile17

Corporate Name：

Leisure, Inc.

Established：

May 25, 2000

Capital：¥881,862,750（as of May 31, 2016）

Business Purpose：

Analysis of Biological Samples and R&D
R&D, Production and Distribution of Medical
Instruments and Device
Clinical Testing Service
Production and Distribution of Medical and Healthrelated Computer Systems
Information Service on the Internet andDistribution of Information Service

Address：

Head Office
2-33-8 Nihombashi Ningyocho,Chuo-ku, Tokyo 103-0013
TEL：+81-3-5645-7371 FAX ：+81-3-5645-7039

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