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Safety Data Sheet
1. Chemical product and company identification
Product name: XYLENE

Company information
Name of manufacturer
Address
Name of section
Telephone number
Facsimile number
Mail address
Reference No： KANTO CHEMICAL CO., INC.
： 2-1, Nihonbashi, Muromachi 2-Chome, Chuo-Ku, Tokyo, 103-0022, Japan： Electronic materials division technical department： +81-3-6214-1080： +81-3-3241-1043： el-info@kanto.co.jp: GE00024 1.3

Recommended uses andrestrictions: Electronic chemicals

2. Hazards identification
GHS classification
Physical hazards

Flammable liquids

Category 3

Health hazards

Acute toxicity(inhalation:vapors)

Category 4

Skin corrosion/irritation

Category 2

Serious eye damage/eyeirritation

Category 2ACarcinogenicity

Category 2

Reproductive toxicity

Category 1BSpecific target organ toxicity(single exposure)

Category 1 (respiratory organs, central nervoussystem)

Specific target organ toxicity(single exposure)

Category 3 (narcosis)

Specific target organ toxicity(repeated exposure)

Category 1 (nervous system, respiratory organs,auditory organs)

Aspiration hazard

Category 1

Aquatic acute

Category 1

Aquatic chronic

Category 2

Environmental
hazards

Hazardpictograms

Signal word:

DangerHazard statements:

Flammable liquid and vapor
May be fatal if swallowed and enters airways
Causes skin irritation
Causes serious eye irritation
Harmful if inhaled
May cause drowsiness or dizziness<< GE00024 XYLENE >>

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Suspected of causing cancer
May damage fertility or the unborn childCauses damage to organs (respiratory organs, central nervoussystem)
Causes damage to organs (nervous system, respiratory organs,auditory organs) through prolonged or repeated exposure
Very toxic to aquatic life
Toxic to aquatic life with long lasting effects
Precautionary statements
Prevention:

Do not handle until all safety precautions have been read andunderstood.
Keep away from heat, hot surfaces, sparks, open flames and otherignition sources. No smoking.
Keep container tightly closed.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use only non-sparking tools.
Take action to prevent static discharges.
Do not breathe mist/vapors.
Wash hands, forearms and face thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Avoid release to the environment.
Wear protective gloves/protective clothing/eye protection/faceprotection.

Response:

IF SWALLOWED: Immediately call a POISON CENTER or doctor.
IF ON SKIN: Wash with plenty of water.
IF ON SKIN (or hair): Take off immediately all contaminatedclothing. Rinse skin with water .
IF INHALED: Remove person to fresh air and keep comfortable forbreathing.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
IF exposed or concerned: Call a POISON CENTER or doctor.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER or doctor if you feel unwell.
Get medical advice/attention if you feel unwell.
Do not induce vomiting.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
Collect spillage.

Storage:

Store in a well-ventilated place. Keep container tightly closed.
Store in a well-ventilated place. Keep cool.
Store locked up.

Disposal:

Dispose of contents/container to hazardous or special waste
collection point, in accordance with local, regional, national
and/or international regulation.

3. Composition/information on ingredients
Distinction of substance or
mixture:Substance

Synonyms:

Dimethylbenzene

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Chemical nameXylene

Concentration(%)
85(as mixtureof o-, m-, p-)

FormulaC6H4(CH3)2

TSCA
ListedEC-No.
215-535-7

CAS RN
1330-20-7＊Contains 15% ethylbenzene as an impurity.

4. First aid measures
First aid measures
First-aid measures afterinhalation:

Remove the victim to fresh air, and make him blow his nose andgargle. If necessary, get medical treatment.

First-aid measures after skincontact:

Wash the affected areas under running water.

First-aid measures after eye
contact:

Wash the affected areas under running water for at least 15minutes. Get medical treatment.

First-aid measures afteringestion:

The chemical is volatile. Do not induce vomiting because it
increases the risk of aspiration into the lungs. Get medical
attention immediately. If necessary, rinse mouth with water.

Personal Protection in FirstAid and Measures:

Rescuers should wear proper protective equipment like rubber
gloves, goggles.

Suitable extinguishing media:

Dry chemical powder, carbon dioxide, dry sand, foam

Unsuitable extinguishing media:

Water spray

Firefighting instructions:

Move containers from fire area if it can be done without risk, if
not possible, apply water from a safe distance to cool andprotect surrounding area.

5. Fire fighting measures

Fight fire from windward.
Dry chemical powder, carbon dioxide or dry sand should be used
for small fires. Foam extinguisher is effective for a large scalefire.
Personal protection (Emergencyresponse):

Firefighters should wear protective equipment.

6. Accidental release measures
Personal Precautions, Protective Equipment and Emergency Procedures
General measures:

Wear proper protective equipment and avoid contact with skin andinhalation of vapor. Conduct operations from upwind and evacuate
people downwind. Remove all sources of ignition. Keep away
personnel except for authorized ones from spillage area by
stretching ropes.

:

Attention should be given to avoid damage to the environment byflowing of spillage to rivers.

Environmental precautions
Environmental precautions

Methods and Equipment for Containment and Cleaning up
For containment:

Absorb spill with inert material （e.g, diatomaceous earth,sand） and flush spillage area with copious amounts of water.

Prevention Measures for
Secondary Accidents:

Remove nearby sources of ignition and prepare extinguishingmedia.

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7. Handling and storage
Handling
Technical measures:

Wear proper protective equipment to avoid contact with skin or
inhalation of vapor. Fire is strictly prohibited.
Ventilate well at working places.

Precautions for safe handling:

Use with an enclosed system or a local exhaust ventilation. Use
in well-ventilated areas.
Do not allow contact with oxidizing substances.

Storage
Storage conditions:

Store in a dark, cool place and tightly closed.

Material used inpackaging/containers:Glass, stainless steel.
Do not use polyvinyl chloride resin, polystyrene, polypropylene.

8. Exposure controls / Personal protection equipment
XyleneACGIHTWA 20 ppm,STEL -Ethylbenzene
ACGIH TWA

20 ppmAppropriate engineering
controls
Protective equipment: Use with an enclosed system or a local exhaust ventilation.

Respiratory protection: Chemical cartridge respirator with an organic vapor cartage orairline respirator

Hand protection: Organic solvents resistant gloves

Eye protection: Safety goggles

Skin and body protection: Protective clothing, protective boots

9. Physical and chemical properties
Physical state: Liquid

Color: Colorless.

Odor: CharacteristicpH: No data available

Melting point: -47.4 °C (as m-xylene)

Freezing point: No data available

Boiling point: 139.3 °C (as m-xylene)

Flash point: 27 °C (C.C.) (as m-xylene)

Auto-ignition temperature: 527 °C (as m-xylene)

Decomposition temperature: No data available

Flammability: Flammable

Vapor pressure: 8 hPa (20℃) (as m-xylene)

Relative density: No data available

Density: 0.860 – 0.870 g/cm³ (20℃)

Relative gas density: 3.66 (as m-xylene)

Solubility: Organic solvents: Soluble in acetone, ethanol, diethyl ether.
Water: 0.02 % (20℃) (as m-xylene)

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Partition coefficient noctanol/water (log Pow)

: 3.2 (as m-xylene)

Explosive limits (vol %): 1.1 – 7 vol % (as m-xylene)

Viscosity, kinematic:: No data available

Particle characteristics: No data available

10. Stability and reactivity
Reactivity: May react with oxidizing substances.

Chemical stability: Stable under normal conditions.

Possibility of hazardous
reactions: Stable under normal conditions of use.

Conditions to avoid: Light, heat.

Incompatible materials: Oxidizing substances.

Hazardous decomposition
products: Carbon monoxide.

11. Toxicological information
Acute toxicity (oral)

Acute toxicity (dermal)

Acute toxicity (inhalation)

Acute toxicity (vapor) Description: No classification
rat LD50=3600mg/kg (as o-xylene)
LD50=4320mg/kg (as m-xylene)
LD50=4029mg/kg (as p-xylene)
LD50=3500-4700mg/kg (as ethylbenzene): No classificationrabbit LD50>3160mg/kg (as o-xylene)
LD50=3228mg/kg (as m-xylene)
LD50=15400mg/kg (as ethylbenzene): No classification (gas)Harmful if inhaledClassification not possible (dust, mist): rat LC50=5303ppm/4h (as o-xylene)
LC50=7328ppm/4h (as m-xylene)
LC50=4740ppm/4h (as p-xylene)
LC40=4000ppm/4h (as ethylbenzene)

Skin corrosion/irritation: Causes skin irritation
m-Xylene : Application of the substance to rabbit skin(application period unknown) caused irritation. In a test in which
13 volunteers soaked their both hands in the substance for 20minutes, they experienced burning sensation after 10 minutes ofexposure, which were reversible within 10 minutes after the end ofexposure. Erythema was observed in the exposure sites, but theeffects faded within a few hours.
Based on the content, this product was classified into category 2.

Serious eye damage/irritation: Causes serious eye irritation
m-Xylene : Application of 0.5 mL of the substance to rabbit eyes
resulted in mild to moderate irritation. Thus, it was classified
into category 2A.
Based on the content, the product was classified into category 2A.

Respiratory sensitization
Skin sensitization
Germ cell mutagenicity: Classification not possible: Classification not possible: No classification
The substance gave negative results in micronucleus assay in mousebone marrow cells in vivo and reverse mutation test in bacteria invitro.

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Carcinogenicity: Suspected of causing cancer
IARC classifies ethylbenzene as group 2B (possibly carcinogenic tohumans).
Based on the content, this product was classified into category 2.

Reproductive toxicity: May damage fertility or the unborn child
Ethylbenzene : The Japan Society for Occupational Healthconsidered that although no clear reproductive toxicity effect isreported for humans, it is certain that reproductive toxicity
occurs in laboratory animals, and they classified it inreproductive toxicants group 2 (suspected human reproductivetoxicant).
Based on the content, the product was classified into category 1B.

STOT-single exposure: Causes damage to organs (respiratory organs, central nervoussystem)
May cause drowsiness or dizzinesso-Xylene : Inhalation exposure in mice caused excitability of thecentral nervous system at low doses and central nervous systemdepression at high doses. The effects on the central nervous
system were observed within the guidance value range of category
1. Xylene isomers cause central nervous system depression,
uncoordinated movements, lying down, and coma. ACGIH reports thatxylene isomers result in respiratory tract irritation.
m-Xylene : There is human evidence including "In inhalation
exposure, nausea, short-term dysmnesia, hyporeactivity, lowered
sense of equilibrium and lowered pulmonary function wereobserved." and "in oral ingestion, pulmonary congestion and dropsy
were noted, and the death was due to central respiratory
depression."
p-Xylene : As for human cases, dizziness was observed in four ofsix volunteers exposed to this substance by inhalation. For
experimental animals, it is reported that inhalation exposure(unknown species of animals, and doses corresponding to category1) caused incoordination, tremors, reduced axonal transport, andat higher doses, narcotic effects; additionally, while theroute(s) of exposure, doses, etc. are not known, tremors, biphasic
central nervous system response (depression and excitement), andgastrointestinal-tract damage were reported as toxic symptoms ofthis substance.
Ethylbenzene : Exposure of volunteers to the substance resulted in
no adverse effects in 100 ppm, but it has been reported that
irritation of the respiratory tract, conjunctivitis, andsomnolence were common above 200 ppm. In a single inhalation
exposure study in mice, lacrimation, decreased respiratory rate,
effects on the central nervous system, sedation, eyes closed, andsensory paralysis were reported.
Based on the content, this product was classified into category 1(respiratory organs, central nervous system) and category 3(narcosis).

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STOT-repeated exposure: Causes damage to organs (nervous system, respiratory organs,auditory organs) through prolonged or repeated exposurem-Xylene : After human volunteers were exposed by inhalation tothe substance for 5 days (6 hours/day), followed by no exposure
on weekend, and then exposed again for one day, they wereevaluated for sense of equilibrium after forced exercise.
Reduced response time at 90-100 ppm and reduced sense ofequilibrium at the high concentration of 400 ppm were observed,indicating neurological effects from even short-term exposure.
Although there are no data on long-term effects from exposure to
the substance alone, it could potentially have the same effects
as xylene (mixture), which suggests that neurological andrespiratory effects are of concern. Animal studies have shownthat in 3-month or 6-month inhalation exposure tests with thesubstance (probably vapor) in male rats, reduced locomotion andincoordination were observed at 100 ppm (category 2), suggestingneurological effects in humans.
Ethylbenzene : Significant hearing loss was seen in workers coexposed to about 30 ppm of ethylbenzene and 85 dB noise than inthose exposed to noise alone, indicating that relatively low
ethylbenzene exposures may be involved in hearing loss. And, theresult of the neurobehavioral function test in this worker was
significantly inferior to the worker of the office work in the
result of "simple reaction time, number of advocation, dexterityof the hand, visual memory power, index tracking power". In
addition, it was reported that acetylcholinesterase activity wassignificantly lower, suggesting inhibition of neuronal function
and disturbance of neurotransmitters.
Based on the content, this product was classified into category
1 (respiratory organs, nervous system, auditory organs).

Aspiration hazard: May be fatal if swallowed and enters airways
The substance (mixture) is a hydrocarbon and its kinematic
viscosity data is not available. Kinematic viscosities of o-, m, p-xylene and ethylbenzene are 0.86, 0.67, 0.70 and 0.74 mm2/s(25℃), respectively. The substance is considered to have asimilar, low kinematic viscosity. Thus, it was classified into
category 1.

12. Ecological information
Ecotoxicity
Aquatic acute

Aquatic chronic: Very toxic to aquatic life
Pseudokirchneriella subcapitata ErC50=0.799mg/L/72h (as oxylene)
Daphnia magana EC50=2.42mg/L/48h (as m-xylene)
Crangon franciscorum LC50=1.7mg/L/96h (as p-xylene)
Crangon franciscorum LC50=0.42mg/L/96h (as ethylbenzene): Toxic to aquatic life with long lasting effects
Daphnia magna NOEC=0.407mg/L/21-day (as o-xylene)
Daphnia magna NOEC=0.407mg/L/21-day (as m-xylene)
Ceriodaphnia dubia NOEC=0.956mg/L/7-day (as ethybenzene)

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Persistence and degradability
No additional information available
Bioaccumulative potential
No additional information available
Mobility in soil
No additional information available
Hazardous to the ozone layerOzone: Classification not possible

13. Disposal considerations
Ecological waste information: Burn in a chemical incinerator equipped with an afterburnerand a scrubber. Or entrust approved waste disposal companies
with the disposal.

Contaminated container andpackaging: In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea(IMDG)
UN-No. (IMDG)
Proper Shipping Name (IMDG)
Packing group (IMDG)
Transport hazard class(es)(IMDG)Air transport(IATA)
UN-No. (IATA)
Proper Shipping Name (IATA)
Packing group (IATA)
Transport hazard class(es)(IATA)::::1307XYLENES
III
3::::

1307
XylenesIII
3

Marine pollutant: Applicable
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC CodePollutant category:Y
MFAG-No:130

15. Regulatory information
Regulatory information with regard to this substance in your country or region should be examined byyour own responsibility.

16. Other information
Data sources: Dictionary of Organic Compounds, The society of Synthetic
Organic Chemistry, Kodansha Ltd.（1985）
Solvents Handbook, T, Asahara el, Kodansha Scientific Ltd.
（1976）
Registry of Toxic Effects of Chemical Substances （RTECS）
1985-86 ed. National Instituted for Occupational Safety andHealth（1987）
Handbook of 17322 Chemical Products, The Chemical Daily Co.
（2022）

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Handbook of Poisonous and Deleterious substances, revised andenlarged edition, Yakumu Kohosa（2000）
NITE Chemical Risk Information Platform (NITE-CHRIP), National
Institute of Technology and Evaluation
The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully.The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements.The information herein is only provision of information, andit does not represent a guarantee the properties of the product.The Safety Data Sheet(SDS) isprepared based on JIS Z7253.