May 19 (Fri.)-May 20 (Sat.), 2023

8:00

The 1st Day : Friday, May 19
Oral Presentation

The 2nd Day : Saturday, May 20
Oral Presentation

8:30~9:35

Session 5

8:00

▶P.6

Pluripotent stem cells

9:00

9:00

O-13~O-15

Chair : Toshihiro Kobayashi
9:30~11:30

9:35~10:55▶P.6

Session 6

10:00

10:00

Cancer stem cells
O-16~O-19

幹細胞若手の会（つくしの会）

Chair : Yohei Shimono

11:00

10:55~11:10

11:00

Coffee Break

11:10~12:30▶P.7

Session 7

Organoid and microenvironmentO-20~O-23

12:00

12:30~12:40

13:00

12:00

Chair : Koji Okamoto

12:45~13:20
13:00~13:05
13:05~13:55

Opening Remarks

Session 1

Keynote Lecture 1

▶P.3

O-01

13:20~13:30
13:30~15:40

General Meeting

Lunch Seminar

13:00

Coffee Break▶P.8

Chair : Atsushi Iwama
14:00

13:55~15:20▶P.3

Session 8

Session 2

Hematopoietic stem cells 2

Hematopoietic stem cells 1

O-24~O-31

O-02~O-06

Chair : Satoshi Yamazaki

Chair : Fumio Arai

15:00
15:20~15:35

15:00

Coffee Break

15:35~17:10

16:00

14:00

▶P.4

15:40~15:50
15:50~15:55

Session 3

Tissue stem cells

Award Announcement
Closing Remarks

16:00

O-07~O-11
Chair : Ritsuko Morita
17:00

17:00
17:10~17:25
17:25~18:10

Miltenyi Biotech technical seminar for
multi-dimensional stem cell research

Session 4

Keynote Lecture 2

▶P.5

O-12

18:00

18:00

Chair : Issay Kitabayashi

18:30~20:00

19:00

19:00

Poster Session

20:00

20:00

20th Stem Cell Research Symposium

2

May 19 (Fri.)-May 20 (Sat.), 2023

The 1st Day

Opening Remarks

13:00～13:05

Session 1: Keynote Lecture 1

13:05～13:55

Chair Atsushi Iwama（The Institute of Medical Science, The University of Tokyo）

O-01
Self-renewal capacity in hematopoietic stem cells
Toshio Suda
(Kumamoto University, IRCMS)

13:55～15:20

Chair Fumio Arai

（Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University）

Invited Lecture(Hematology, Kobe University Hospital)

O-03（14:20～14:35）
Akkermansia muciniphila induces delayed extramedullary hematopoiesis throughcooperative IL-R and TLR signals
Yuxin Wang1, Tatsuya Morishima1,2 , Maiko Sezaki1,2 , Ryo Sato1,
Gaku Nakato3 , Shinji Fukuda3,4,5 , Yuhua Li6 , Hitoshi Takizawa1,7(1Laboratory of Stem Cell Stress, International Research Center for Medical
Sciences (IRCMS), Kumamoto University, Kumamoto, Japan, 2Laboratory of
Hematopoietic Stem Cell Engineering, IRCMS, Kumamoto University, Kumamoto,Japan, 3Gut Environmental Design Group, Kanagawa Institute of Industrial
Science and Technology, Kanagawa, Japan, 4Institute for Advanced Biosciences(IAB), Keio University, Tokyo, Japan, 5Transborder Medical Research Center,
University of Tsukuba, Ibaraki, Japan, 6Department of Hematology, Zhujiang
Hospital, Southern Medical University, Guangzhou, China, 7Center for Metabolic
Regulation of Healthy Aging (CMHA), Kumamoto University, Kumamoto, Japan)(1Department of Hematology and Oncology, Graduate School of Medicine, The
University of Tokyo, 2Department of Cell Therapy and Transplantation, The
University of Tokyo Hospital)

3

20th Stem Cell Research Symposium

Abstract / Poster

O-04（14:35～14:50）
Genome-wide screen in myeloid leukemia cell lines identifies novel upstream
regulatory factors of the EVI1 gene
Hiroki Hayashida1, Yosuke Masamoto1, Toshiya Hino1, Ken Morita1,
Mineo Kurokawa1,2

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-02（13:55～14:20）
Nervous-skeletal-hematopoietic integration to understand the phenomena in clinicalhematology
Yoshio Katayama

Program / Poster

Session 2: Hematopoietic stem cells 1

Program / 1st Day Program / 2nd Day

Friday, May 19.

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 19 (Fri.)-May 20 (Sat.), 2023

O-05（14:50～15:05）
Regulation of hematopoietic stem cell aging by adaptive immunity
Yuko Tadokoro, Atsushi Hirao(Division of Molecular Genetics, Cancer Research Institute, WPI Nano Life Science
Institute, Kanazawa University)

O-06（15:05～15:20）
Trisomy 8 remodels epigenome and activates transcription of canonical Runx1-target
genes in hematopoietic stem cell
Goro Sashida, Jie Bai, Sho Kubota(International Research Center for Medical Sciences, Kumamoto University)

Coffee Break

15:20～15:35

Session 3: Tissue stem cells

15:35～17:10

Chair Ritsuko Morita（Graduate School of Frontier Biosciences, Osaka University）

Invited Lecture

O-07（15:35～16:00）
Mechanism of aging-induced intestinal stem cell proliferation in Drosophila
Sa Kan Yoo（RIKEN）

Invited Lecture

O-08（16:00～16:25）
Chromosome abnormalities in early embryos
Hirohisa Kyogoku1,2 , Saori Takahashi3 , Ichiro Hiratani3 ,Tomoya S Kitajima 2（1Kobe University, Graduate School of Agricultural Science, Japan, 2Lab for
Chromosome segregation, RIKEN BDR, Japan, 3Lab for Developmental
epigenetics, RIKEN BDR, Japan）

O-09（16:25～16:40）
Self-maintenance strategies of neural stem/progenitor cells via autocrine VEGF-A
under hypoxia in the developing brain
Taichi Kashiwagi1,2 , Yuuki Takazawa 2 , Tetsushi Kagawa 2 , Tetsuya Taga 2(1Tokyo Medical University, Department of Histology and Neuroanatomy, 2Tokyo
Medical and Dental University, Department of Stem Cell Regulation, Medical
Research Institute)O-10（16:40～16:55）
Tracing intestinal p57+ cells uncovers spatiotemporal reprogramming of regenerating
epithelium and the identity of cancer stem cells
Tsunaki Higa, Takeru Oka, Yasutaka Okita, Matsumoto Akinobu,
Keiichi I. Nakayama(Department of Molecular and Cellular Biology, Medical Institute of Bioregulation,
Kyushu University)

20th Stem Cell Research Symposium

4

May 19 (Fri.)-May 20 (Sat.), 2023

(1Life Science Center for Survival Dynamics, TARA, University of Tsukuba,
2
Institute of Physiology I, University of Bonn)

Miltenyi Biotech technical seminar for multi-dimensional stem cell research

17:10～17:25

Presenter Sohei Nakayama（Miltenyi Biotec K.K.）

Sponsored by : Miltenyi Biotec K.K.

17:25～18:10

Session 4: Keynote Lecture 2（National Cancer Center Research Institute）

O-12
Cell Analysis with Networked Measurement Machines
Sadao Ota

(Research Center for Advanced Science and Technology, The University of Tokyo)

Program / Poster

Chair Issay Kitabayashi

Program / 1st Day Program / 2nd Day

O-11（16:55～17:10）
Bone marrow CD73+ mesenchymal stem cells display increased stemness and promote
fracture healing
Kenichi Kimura1, Bernd K. Fleischmann2 , Hiromi Yanagisawa1

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)
Abstract / Poster

5

20th Stem Cell Research SymposiumAbstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 19 (Fri.)-May 20 (Sat.), 2023

Saturday, May 20.

The 2nd Day
8:30～9:35

Session 5: Pluripotent stem cells

Chair Toshihiro Kobayashi（Division of Mammalian Embryology, Center for Stem Cell Biology andRegenerative Medicine, The Institute of Medical Science, The University of Tokyo）

Invited LectureO-13（8:30～8:55）
Reconstituting human axial development & disease in vitro
Cantas Alev

（Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University）

Invited LectureO-14（8:55～9:20）
Molecular programming for human early germ cell development
Naoko Irie

(Metabolic Systems Laboratory, Live Imaging Center, Central Institute forExperimental Animals)

O-15（9:20～9:35）
Self-organization, quality control, and preclinical studies of human iPSC-derived
retinal sheets for first-in-human clinical research
Atsushi Kuwahara1, Kenji Watari1, Suguru Yamasaki1, Tatsuya Kamei1,
Hideki Adachi2 , Tomoaki Tochitani2 , Yasuyuki Kita1, Masayo Fujiwara1,
Yoriko Hori1, Anna Tanabe1, Rina Hirai1, Keiichi Ono3 , Kazuki Ueyama3 ,Aya Nakamura3 , Tetsuya Hayama1, Akiyoshi Kishino1, Atsushi Ikeda1,
Shin Kawamata4 , Michiko Mandai5,6 , Toru Kimura1(1Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd.,
2
Preclinical Research Unit, Research Division, Sumitomo Pharma Co., Ltd.,
3
Technology Research & Development Division, Sumitomo Pharma Co., Ltd.,
4
Research & Development Center for Cell Therapy, Foundation for Biomedical
Research and Innovation at Kobe, 5Laboratory for Retinal Regeneration, RIKEN
Center for Biosystems Dynamics Research, 6RIKEN Program for Drug Discovery
and Medical Technology Platforms, RIKEN Cluster for Science, Technology andInnovation Hub.)

9:35～10:55

Session 6: Cancer stem cells

Chair Yohei Shimono（Fujita Health University）

Invited Lecture

O-16（9:35～10:00）
Early stages of pancreatobiliary cancer development
Hiroshi Seno, Munemasa Nagao, Mio Namikawa, Yuichi Fukunaga,
Takahisa Maruno, Akihisa Fukuda(Kyoto University, Department of Gastroenterology & Hepatology)

20th Stem Cell Research Symposium

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May 19 (Fri.)-May 20 (Sat.), 2023

O-17（10:00～10:25）
Cellular heterogeneity of tumor stem cells causes treatment resistance
Norikatsu Miyoshi1,2(1Department of Innovative Oncology Research and Regenerative Medicine, Osaka
International Cancer Institute, 2Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University)

O-18（10:25～10:40）
γ-Glutamylcyclotransferase, a novel regulator of cancer stem cell properties inbreast cancer
Takanori Hayashi1, Seiji Okada 2 , Munetsugu Hirata1, Yasuyoshi Mizutani1,
Yuko Kijima1, Motoshi Suzuki1, Yohei Shimono1(1Fujita Health University School of Medicine, 2Joint Research Center for Human
Retrovirus Infection, Kumamoto Univ.)(Institute of Medical Science, the University of Tokyo)

10:55～11:10

Session 7: Organoid and microenvironment

11:10～12:30

Chair Koji Okamoto（Teikyo University
Advanced Comprehensive Research Organization）

Invited LectureO-20（11:10～11:35）
Cancer evolution by positive selection and negative selection
Masanobu Oshima1, Sau Yee Kok1, Dong Wang2 , Mizuho Nakayama1,
Hiroko Oshima1(1Cancer Research Institute, Kanazawa University, 2Nano Life Science Institute,
Kanazawa University)

Invited LectureO-21（11:35～12:00）
Application of organoid/spheroid culture as tools for understanding heterogeneity,
chemoresistance, and metastasis of refractory cancers
Koji Okamoto(Teikyo University, Advanced Comprehensive Research Organization)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

Coffee Break

Program / Poster

O-19（10:40～10:55）
Developing next-generation drug sensitivity screening using primary tumor specimens
derived from patients of myeloid malignancies
Kimihito Cojin Kawabata, Yasuhito Nannya, Satoshi Takahashi

Program / 1st Day Program / 2nd Day

Invited Lecture

Abstract / Poster

7

20th Stem Cell Research Symposium

O-22（12:00～12:15）
The membrane-linked adaptor FRS2β fashions a cytokine-rich microenvironment that
promotes breast cancer carcinogenesis
Yasuto Takeuchi1, Natsuko Kimura1, Takahiko Murayama1,
Yukino Machida 2 , Daisuke Iejima 2 , Tatsunori Nishimura1,
Minoru Terashima 3 , Wang Yuming1, Mengjiao Li1, Rieko Sakamoto4 ,Mizuki Yamamoto5, Naoki Itano6 , Yusuke Inoue7, Masataka Ito8 ,Nobuaki Yoshida4 , Jun-ichiro Inoue5, Koichi Akashi9, Hideyuki Saya10,
Koji Fujita11, Masahiko Kuroda11, Issay Kitabayashi12 , Voon Dominic13 ,Takeshi Suzuki14 , Arinobu Tojo2 , Noriko Gotoh1(1Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University,
2
Division of Molecular Therapy, Institute of Medical Science, University of Tokyo,
3
Division of Functional Genomics, Cancer Research Institute, Institute for Frontier
Science Initiative, Kanazawa University, 4Laboratory of Developmental Genetics,
Institute of Medical Science, University of Tokyo, 5Division of Cellular andMolecular Biology, Institute of Medical Science, University of Tokyo, 6Departmentof Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University,
7
Department of Diagnostic Radiology, Kitasato University of School of Medicine,8
Department of Anatomy, National Defense Medical College, 9Department ofMedicine and Biosystemic Science, Graduate School of Medicine, Kyushu
University, 10Division of Gene Regulation, Insitute of Advanced Medical Research,
Keio University, 11Department of Molecular Pathology, Tokyo Medical University,
12
Division of Hematological Malignancy, National Cancer Center ResearchInstitute, 13Cancer Research Institute, Institute for Frontier Science Initiative,
Kanazawa University, 14Division of Functional Genomics, Cancer ResearchInstitute, Institute for Frontier Science Initiative, Kanazawa University)

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 19 (Fri.)-May 20 (Sat.), 2023

O-23（12:15～12:30）
Nociceptive nerves facilitate hematopoietic stem and progenitor cell homing to bonemarrow by regulating microcirculation
Shinya Fujita1,2 , Takayuki Morikawa1, Keisuke Kataoka 2,3 , Keiyo Takubo1(1Department of Stem Cell Biology, Research Institute, National Center for Global
Health and Medicine, Tokyo, Japan, 2Division of Hematology, Department ofMedicine, Keio University School of Medicine, Tokyo, Japan, 3Division of Molecular
Oncology, National Cancer Center Research Institute, Tokyo, Japan)

General Meeting

12:30～12:40

Lunch Seminar: Recent advances in CAR-T therapy

12:45～13:20

Chair Koichi Akashi（Kyushu University）

Presenter Koji Kato

（Kyushu University）

Sponsored by: LSI Medience Corporation

Coffee Break

13:20～13:30

Session 8: Hematopoietic stem cells 2

13:30～15:40

Chair Satoshi Yamazaki（University of Tsukuba）

20th Stem Cell Research Symposium

8

May 19 (Fri.)-May 20 (Sat.), 2023

O-24（13:30～13:55）
Development of the hematopoietic system in the mouse embryo
Tomomasa Yokomizo(Tokyo Women’s Medical University)O-25（13:55～14:10）
A large scale paired-daughter cell analysis reveals that hematopoietic stem cells
exhibit different division patterns according to subtypes
Yosuke Tanaka1, Tsuyoshi Fukushima 2 , Toshio Suda1, Toshio Kitamura3(1IRCMS, Kumamoto University, 2Center for Regenerative Medicine,
Massachusetts General Hospital, Harvard Stem Cell Institute and the Departmentof Stem Cell and Regenerative Biology, Harvard University, 3Division of Cellular
Therapy, IMS, The University of Tokyo)

O-27（14:25～14:40）
Rasip1 gene functioning downstream of Sox17 maintains the hematopoietic
cluster-forming cells in E10.5 mouse embryos
Gerel Melig1, Ikuo Nobuhisa1,2 , Kiyoka Saito1, Ryota Tsukahara1,
Ayumi Itabashi1, Yoshiakira Kanai3 , Masami Kanai-Azuma4 , Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University, 2Department of Nutritional Science, Faculty of Nutritional
Sciences, Nakamura Gakuen University, 3Department of Veterinary Anatomy,
Graduate School of Agricultural and Life Science, University of Tokyo,
4
Department of Experimental Animal Model for Human Disease, Center for
Experimental Animals, Tokyo Medical and Dental University)O-28（14:40～14:55）
Unveiling highly fluctuating single-cell transcriptome dynamics at a novel bifurcation
point in a human lymphoid pathway
Keiki Nagaharu1,2 , Yasuhiro Kojima 3 , Haruka Hirose3 , Kodai Minoura3 ,Kunihiko Hinohara4,5, Yuka Sugimoto6 , Shigeru Nii7, Masahide Seki8 ,Yutaka Suzuki8 , Isao Tawara6 , Teppei Shimamura3 , Naoyuki Katayama6 ,Hiroyoshi Nishikawa4,5,9,10, Kohshi Ohishi6

9

20th Stem Cell Research Symposium

Abstract / Poster(1Department of Hematology and Oncology, Mie University Graduate School of
Medicine, 2Yokkaichi Municipal Hospital, 3Division of Systems Biology, Nagoya
University Graduate School of Medicine, 4Department of Immunology, Nagoya
University Graduate School of Medicine, 5Institute for Advanced Research,
Nagoya University, 6Department of Hematology and Oncology, Mie University
Graduate School of Medicine, 7Shiroko Women’s Hospital, 8Department ofComputational Biology and Medical Sciences, The University of Tokyo, 9Divisionof Cancer Immunology, Research Institute, National Cancer Center, 10Division ofCancer Immunology, Exploratory Oncology Research and Clinical Trial Center(EPOC), National Cancer Center)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

(1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology andRegenerative Medicine, The Institute of Medical Science, The University of Tokyo,
Tokyo, Japan., 2Department of Immunology, Yokohama City University Graduate
School of Medicine, Yokohama, Japan., 3Advanced Medical Research Center,
Yokohama City University, Yokohama, Japan.)

Program / Poster

O-26（14:10～14:25）
Two distinctive hematopoietic stem cell populations coordinate hematopoietic aging
Shuhei Koide1, Motohiko Oshima1, Akira Nishiyama 2 , Koichi Murakami2,3 ,Naoki Itokawa 2 , Yuta Yamada 2 , Yaeko Nakajima-Takagi2 , Zhiqian Zheng2 ,Tomohiko Tamura 2,3 , Atsushi Iwama 2

Program / 1st Day Program / 2nd Day

Invited LectureO-29（14:55～15:10）
Functional analysis of novel mesenchymal stem cells in the endosteal niche ofhematopoietic stem cells
Hisayuki Yao, Ryosuke Yuta, Fumio Arai

(Stem Cell Regulation/ Cancer Stem Cell, Department of Stem Cell Biology andMedicine, Graduate School of Medical Sciences, Kyushu University)

O-30（15:10～15:25）
Terminal erythroid differentiation is mediated by mitochondrial translation throughregulation of iron homeostasis
Tatsuya Morishima1,2 , Md. Fakruddin1,2 , Takeshi Masuda3 , Yuxin Wang1,
Vivien A. C. Schoonenberg4 , Falk Butter4 , Yuichiro Arima 5,
Takaaki Akaike6 , Kazuhito Tomizawa7, Fan-Yan Wei8 , Toshio Suda9,10,
Hitoshi Takizawa1(1Laboratory of Stem Cell Stress, International Research Center for Medical
Sciences (IRCMS), Kumamoto University, 2Laboratory of Hematopoietic Stem Cell
Engineering, IRCMS, Kumamoto University, 3Department of Pharmaceutical
Microbiology, Faculty of Life Sciences, Kumamoto University, 4Quantitative
Proteomics, Institute of Molecular Biology, Mainz, Germany, 5Laboratory ofDevelopmental Cardiology, IRCMS, Kumamoto University, 6Department ofEnvironmental Medicine and Molecular Toxicology, Tohoku University Graduate
School of Medicine, 7Department of Molecular Physiology, Faculty of Life Sciences,
Kumamoto University, 8Department of Physiology and Metabolism, IDAC, Tohoku
University, 9Laboratory of Stem Cell Regulation, IRCMS, Kumamoto University,
10
Cancer Science Institute of Singapore, National University of Singapore)O-31（15:25～15:40）
Functional HSCs Preferentially Migrate to Spleen During Hematopoietic Regeneration
Alban Johansson1, Ahad Khalilnezhad2 , Hitoshi Takizawa3 ,Hidenobu Mizuno4 , Toshio Suda5, Terumasa Umemoto1(1Laboratory of Hematopoietic Stem Cell Engineering, International ResearchCenter for Medical Sciences, Kumamoto University, Japan, 2Department of
Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston,
MA, USA, 3Laboratory of Stem Cell Stress, International Research Center for
Medical Sciences, Kumamoto University, Japan, 4Laboratory of Multi-dimensional
imaging, International Research Center for Medical Sciences, Kumamoto
University, Japan, 5Laboratory of Stem Cell Regulation, International ResearchCenter for Medical Sciences, Kumamoto University, Japan)

Award Announcement

15:40～15:50

Closing Remarks

15:50～15:55

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 19 (Fri.)-May 20 (Sat.), 2023

20th Stem Cell Research Symposium

10

May 19 (Fri.)-May 20 (Sat.), 2023

P-01 Elongation of long-chain fatty acids is crucial for hematopoietic stem cellengraftment and leukemia propagation
Takayasu Kato1,2 , Yusuke Kiyoki1, Sakura Kito3 , Takashi Matsuzaka4 ,Shin Morioka5, Junko Sasaki5, Tatsuhiro Sakamoto1, Hidekazu Nishikii1,
Naoshi Obara1, Mamiko Sakata-Yanagimoto1,4 , Takehiko Sasaki3 ,Hitoshi Shimano6 , Shigeru Chiba1

P-02 Screening of TPO receptor agonists for efficient ex-vivo expansion of humanhematopoietic stem cells in polymer based culture system
Riko Kikuchi1, Kantaro Ishitsuka1, Takaharu Kimura1, Hidekazu Nishikii2 ,Satoshi Yamazaki1(1Stem Cell Therapy, Institute of Medicine, University of Tsukuba, 2Department of
Hematology, Institute of Medicine, Univerisity of Tsukuba)(Department of Microscopic and Developmental Anatomy, Tokyo Women’s
Medical University)

P-04 Chromatin remodeling factors BRM and BRG1 regulate the rapid immune
response in hematopoietic cells
Hiroki Nishikawa, Haruka Suzuki, Hiroki Miyachi, Tatsuro Shiina,
Nonoko Kawabata, Tsuyoshi Imasaki, Ryo Nitta, Eriko Nitta(Division of Structural Medicine and Anatomy, Kobe University Graduate Schoolof Medicine)P-05 Chromatin remodeling factor BRM maintains hematopoietic stem cells via thebone marrow microenvironment niche
Haruka Suzuki1, Hiroki Miyachi1, Hiroki Nishikawa1, Tatsuro Shiina1,
Nonoko Kawabata1, Ryo Yoshikawa 2 , Yoshiaki Sakihama1,
Tomiyoshi Setsu1, Satoshi Kikkawa1, Tsuyoshi Imasaki1, Ryo Nitta1,
Eriko Nitta1(1Division of Structural Medicine and Anatomy, Kobe University Graduate Schoolof Medicine, 2Kobe University Orthopaedic Surgery)(1Research Institute, National Center for Global Health and Medicine, 2Graduate
School of Medicine, Kyoto University, 3Nippon Medical School, 4Graduate School of
Medicine, Chiba University, 5Institute of Medical Science, The University ofTokyo)

11

20th Stem Cell Research Symposium

Abstract / Poster

P-06 The Pbx1-G9a axis dysregulates lineage output of aged hematopoietic stem
cells
Hiroshi Kobayashi1, Shintaro Watanuki1, Yusuke Shiozawa 2,3 ,Naoya Takayama4 , Seishi Ogawa 2 , Atsushi Iwama5, Keiyo Takubo1

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-03 Thrombopoietin deficiency accelerates LPS-induced inflammatory response
Ayano Yahagi, Makiko Mochizuki-Kashio, Tomomasa Yokomizo,
Ayako Nakamura-Ishizu

Program / Poster(1Department of Hematology, Faculty of Medicine, University of Tsukuba, Ibaraki,
Japan., 2Department of Laboratory Medicine, Faculty of Medicine, University ofTsukuba, Ibaraki, Japan., 3Graduate School of Comprehensive Human Sciences,
University of Tsukuba, Ibaraki, Japan, 4Division of Advanced Hemato-Oncology,
Transborder Medical Research Center, University of Tsukuba, Ibaraki, Japan.,5Department of Lipid Biology, Graduate School of Medical and Dental Sciences,
Tokyo Medical and Dental University, Tokyo, Japan., 6Department ofEndocrinology and Metabolism, Faculty of Medicine, University of Tsukuba,
Ibaraki, Japan.)

Program / 1st Day Program / 2nd Day

Poster Session

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 19 (Fri.)-May 20 (Sat.), 2023

P-07 Phip deficiency leads to the expansion of hematopoietic stem/progenitor cells
and splenomegaly upon aging
Yuko Kato1, Takako Yokomizo2 , Goro Sashida 3 , Atsushi Iwama 2 ,Satoru Miyagi4(1Department of Life Science, Faculty of Medicine, Shimane University, 2Divisionof Stem Cell and Molecular Medicine, Center for Stem Cell Biology andRegenerative Medicine, The Institute of Medical Science, The University of Tokyo,
3
International Research Center for Medical Sciences, Kumamoto University,
4
Department of Biochemistry, Faculty of Medicine, Shimane University)

P-08 Distinct subunit composition between Polycomb bodies within the nucleus of aneocortical neural stem-progenitor cell
Natsumi Yamada1, Kazunori Hojo1, Hiroki Sugishita1,2 , Yukiko Gotoh1,2(1Graduate School of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences,
The University of Tokyo, 2International Research Center for Neurointelligence(WPI-IRCN), The University of Tokyo)

P-09 Development of synthetic polymer scaffolds mimicking a niche that maintains
neural stem cells in a growth factor- and serum-free system
Norihisa Bizen1,2 , Kouichi Tabu1, Mei Wu3 , Christian Mangani3 ,Rong Zhang3 , Mark Bradley3 , Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU), Tokyo, Japan, 2Division of Neurobiology andAnatomy, Graduate School of Medical and Dental Sciences, Niigata University,
Niigata, Japan, 3EaStChem, School of Chemistry, University of Edinburgh,
Edinburgh, London, United Kingdom)

P-10 The balance between ERK/MAPK and IFN-g signaling activities regulates
intestinal epithelial homeostasis during aging
May Nakajima-Koyama1, Eisuke Nishida 2 , Takuya Yamamoto1,3,4(1Center for iPS Cell Research and Application (CiRA), Kyoto University, 2RIKEN
Center for Biosystems Dynamics Research (BDR), 3Institute for the Advanced
Study of Human Biology (ASHBi), Kyoto University, 4Medical-Risk Avoidance
Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP))

P-11 Strain differences in cellular dynamics characteristic of carcinogenesis in the
mammary gland after radiation exposure
Daisuke Iizuka, Mari Ogawa, Mayumi Shinagawa, Chizuru Tsuruoka,
Masaaki Sunaoshi, Tatsuhiko Imaoka, Shizuko Kakinuma(Department of Radiation Effects Research, National Institute of Radiological
Sciences, QST)

P-12 Dermatan sulphate contributes to differentiation and self-renewal in stem cells
Chika Ogura1, Kazumi Hirano2 , Shuji Mizumoto3 , Shuhei Yamada3 ,Shoko Nishihara4(1Department of Science and Engineering for Sustainable Innovation, Faculty of
Science and Engineering, Soka University, 2Molecular Neurophysiology ResearchGroup, Biomedical Research Institute, The National Institute of Advanced
Industrial Science and Technology (AIST), 3Department of Pathobiochemistry,
Faculty of Pharmacy, Meijo University, 4Department of Bioinformatics, Graduate
School of Engineering, Soka University Glycan & Life System Integration Center(GaLSIC), Soka University)

20th Stem Cell Research Symposium

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May 19 (Fri.)-May 20 (Sat.), 2023

(1Department of Bioinformatics, Graduate School of Engineering, Soka University,2
Department of Science and Engineering for Sustainable Innovation, Faculty of
Science and Engineering, Soka University, 3National Institute of Radiological
Sciences (NIRS), National Institutes for Quantum and Radiological Science andTechnology, 4Department of Integrated Biosciences, Graduate School of Frontier
Sciences, The University of Tokyo, 5Glycan & Life Systems Integration Center(GaLSIC), Soka University)

P-14 Essential roles of TIP60 in acute myeloid leukemia with NPM mutation
Yukiko Aikawa, Kazutune Yamagata, Issay Kitabayashi(Division of Hematological Malignancy, National Cancer Center Research Institute)(Division of Hematological Malignancy, National Cancer Center Research Institute)(1Department of Biochemistry, Fujita Health University School of Medicine,2
Department of Medical Oncology, Fujita Health University School of Medicine,3
Department of Pathology, Fujita Health University School of Medicine,
4
Laboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba,
5
Department of Molecular Oncology, Fujita Health University School of Medicine,
6
Joint Research Center for Human Retrovirus Infection, Kumamoto University)

P-17 Pathogenic mechanism of amino acid metabolism in acute myeloid leukemia
Hiromi Yamazaki, Hiromi Ito, Koutarou Nishimura, Yui Koike,
Inoue Daichi(Department of Hematology–Oncology, Institute of Biomedical Research andInnovation, Foundation for Biomedical Research and Innovation at Kobe)

P-18 Uncovering the unrecognized roles on cell fate and leukemogenesis of p53
mutations
Koutarou Nishimura, Weijia Zang, Hiromi Ito, Yui Koike, Daichi Inoue(Department of Hematology-Oncology, Institute of Biomedical Research andInnovation, Foundation for Biomedical Research and Innovation at Kobe)

P-19 In vivo visualization of senescence-associated gene expression during cancer
development
Fumie Nakasuka, Nao Sankoda, Sho Ohta, Yasuhiro Yamada

13

20th Stem Cell Research Symposium

Abstract / Poster(Department of Molecular Pathology, Graduate School of Medicine, The Universityof Tokyo)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-16 Adipocytes promote cancer stem cell properties and metastatic progression ofbreast cancer cells through adipsin
Behnoush Khaledian1, Jumpei Yoshida1,2 , Masahiro Mizuno1,
Masao Maeda1,3 , Takanori Hayashi1, Eiji Munetsuna1, Seiya Mizuno4 ,Yasuyoshi Mizutani5, Seiji Okada6 , Motoshi Suzuki5, Fumihiro Sugiyama4 ,Satoru Takahashi4 , Naoya Asai3 , Kenji Kawada 2 , Yohei Shimono1

Program / Poster

P-15 CCTC-binding factor (CTCF) is necessary for development and maintenance of
CALM-AF10-induced leukemia
Yoko Kuroki, Yukiko Aikawa, Kazutsune Yamagata, Issay Kitabayashi

Program / 1st Day Program / 2nd Day

P-13 O-GlcNAc on serine 111 of Psme3 is a key proteasome regulator for mouseembryonic stem cell pluripotency by controlling P-body homeostasis
Hayato Ota1, Federico Pecori1, Nanako Kondo2 , Chika Ogura 2 ,Taichi Miura1,3 , Masahiko Kume4 , Youhei Minamijima4 , Kazuo Yamamoto4 ,Shoko Nishihara1,2,5

May 19 (Fri.)-May 20 (Sat.), 2023

参加者へのご案内とお願い
1．参加者の皆様へ
今大会は参加者の皆様に安心してご来場いただけますよう、新型コロナウイルス（COVID - 19）の感染対策を徹底した運営を行い、「現地開催」とさせていただきます。
なお、今大会の発表言語は「日本語」としますが、抄録、スライド、ポスターの表示は「英語」とします。
開催に向けて最善の準備を行うよう努めて参りますので、ご理解とご支援のほど、何卒よろしく
お願い申し上げます。
2．参加登録について
2 - 1．受付場所：兵庫県立淡路夢舞台国際会議場 2F（〒656 - 2306 兵庫県淡路市夢舞台1番地）
2 - 2．受付時間：5月19日（金）12時～
2 - 3．参 加 費：10,000円

ロビー

3．口演発表について
3 - 1．発表時間
・事前に通知された発表時間内でのご発表をお願いいたします。
3 - 2．発表形式
・ご発表はすべて PC によるプレゼンテーションとなります。
・PowerPoint を用いて作成したデータを、演台上に設置された PC を使用して、発表していただきます。
3 - 3．データ受付
1）ファイル名は「演題番号演者名.pptx」としてください。必ずバックアップ用のデータも、お持ちくださるようお願いいたします。
2）ご講演の一つ前のセッション開始までに、必ず PC 受付にて試写を終えていただきます
ようお願いいたします。
3）PC 受付では、PC 本体（Windows または Macintosh）あるいは、メディア（CD - R または USB フラッシュメモリ）で受付させていただきます。
4）メディア持ち込みの場合、受付したデータは発表用 PC にインストールします。発表用
PC の OS は Windows で、アプリケーションは PowerPoint です｡ 発表後のデータは、シンポジウム終了後に事務局で削除いたします。
5）PC 本体持ち込みの場合、Windows、Macintosh 共に使用可能です。
・また、外部モニター接続端子（MiniD - sub15ピン）を確認の上、コネクタを必要とする場合はこちらもご持参ください。
・AC アダプターを必ずご持参くださいますようお願いいたします。
・予め、スクリーンセーバーならびに省電力設定を「なし」にしてください。
・PC 本体持ち込みの場合でも、CD - R または USB フラッシュメモリに保存したバック
アップデータをご用意ください。
6）動画のある方やアニメーション効果を多用される場合は、ご自身の PC をご持参ください。

20th Stem Cell Research Symposium

44May 19 (Fri.)-May 20 (Sat.), 2023

4．ポスターセッションについて
20㎝
70㎝
4 - 1．ポスター会場
・淡路夢舞台国際会議場 2F
20㎝
演題名・演者名・所属名
レセプションホール B
4 - 2．ポスター貼付
・5月19日（金）13時～
演題番号・通知されたポスター番号に従い、掲示をお（事務局で準備）
願いいたします。
4 - 3．ポスター発表
160㎝
205㎝
・発表は、5月19日（金）18時30分～です。
本文スペース・発表時間になりましたら、ご自身のポス
ター前で待機していただき、閲覧者からの質問への回答、発表、討議を行ってください。
4 - 4．貼付パネル
・パネルの大きさは全体で縦205cm×横90cm（貼付しない）25㎝です。（演題番号は事務局準備）
・演題名・演者名・所属名は縦20cm×横70cm、90㎝
本文は縦160cm×横90cm 以内でお願いいたします。
4 - 5．ポスター撤去
・2日目（5月20日（土））の11時以降、各自の責任で撤去してお帰りください。
・撤去されないポスターは事務局にて処分させていただきますので、予めご了承ください。

5．宿泊先について（事前にお申し込みいただきました先生方へ）
5 - 1．宿泊施設
・グランドニッコー淡路
5 - 2．宿泊受付
・5月19日（金）15時20分からの Coffee Break 時に、メインホール（口演会場）のホワイエにて、宿泊の方全員のキーケースを机に並べておりますので、各自でお取りください。
・それ以降の時間帯につきましては、ホテルフロントにて各自でチェックインをお願いします。
5 - 3．宿泊費（朝食付き、税金・サービス料込み）15,000円
・5月20日（土）のチェックアウト時に各自でお支払いください。
6．問合せ先第20回幹細胞シンポジウム事務局（東京大学医科学研究所 システム疾患モデル研究センター）E - mail：scrs - office@umin.ac.jp
幹細胞シンポジウムホームページ
http://stem - cell.jp

45

20th Stem Cell Research Symposium

May 19 (Fri.)-May 20 (Sat.), 2023

Registration Hours and PC/Data Registration
Registration Hours : May 19（Fri）12：00pm 

Awaji Yumebutai International Conference Center

PC/Data Registration :1. Please check your presentation date and time, and bringyour PC/Data to the PC desk next to the registration
desk at least one session prior to your scheduled presentation.
2. Please bring backup of your presentation data（USB flash
memory）.Only the software “PowerPoint” is allowed.
3. Please name the file as [Presentation number_Name of first author.pptx].
4. When you presentation, please use the PC on the lectern to project your PowerPoint data by using “Share Screen” function on Zoom.
5. If you are bringing your own PC, you may bring either Windows or Macintosh. Please install
Zoom application in advance as you are requested to use “Share Screen” function on Zoom tomake your presentation.
6. Please confirm the LAN port (network cable (LAN cable) outlet), and be sure to bring the connector if you need it.
7. Please check your PC’s “Mini D - Sub 15 pin”. If your PC does not have the port, please bring a
converting adaptor.
** Mini D - Sub 15 pin is a junction part of a cable which connects your PC with a projector.
8. If you prefer to bring your own PC for the presentation, please do not fail to bring your AC adapter.

20th Stem Cell Research Symposium

46

May 19 (Fri.)-May 20 (Sat.), 2023

交通案内
交通機関でのルート
姫路

大阪国際空港
新神戸

西明石
明石港

新幹線
J

舞子

明石海峡大橋R

高速艇・フェリー

三ノ宮

新大阪
大阪

神戸空港

岩屋港

空港リムジンバス

東浦 IC

淡路夢舞台
国際会議場

関西国際空港

大鳴門橋
徳島空港

大
阪
駅

大
阪
国
際
空
港
（
伊
丹
空
港
）

徳
島
市
内

バス 15分

JR 45分

新
神
戸
駅

神
戸
空
港

地下鉄 3分

JR 20分

JR 10分

バス 15分

ポートライナー 18分
バス 40分

関
西
国
際
空
港

舞
子
駅

三
ノ
宮
駅

バス 新神戸発 三ノ宮経由 60分
三ノ宮発 45分

路
夢
台

東
浦
IC

リムジンバス 90分

高
速
舞
子

48

国
タクシー 10分

岩屋
港

高速艇 15分

バス 75分20th Stem Cell Research Symposium

淡舞リムジンバス
65分

明
石
港

西
明
石
駅

際
会

バス 10分

バス 15分

議場

May 19 (Fri.)-May 20 (Sat.), 2023

49

20th Stem Cell Research Symposium