May 29 (Fri)-May 30 (Sat), 2015

Friday, May 29.

The First Day

Registration・Exhibit posters

9:00〜

Opening Remarks Organizer Issay Kitabayashi

9:30〜9:40(National Cancer Center Research Institute, Division of Hematological
Mallignancy)

9:40〜10:30

Keynote Lecture (1)Chair Yukiko Gotoh(Laboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences,
The University of Tokyo)

K-1 Molecular Regulation of Stem Cell QuiescenceThomas A. Rando, MD, PhD(Stanford University School of Medicine)

Coffee Break

10:30〜10:50

Special Session on Tissue Stem Cells

10:50〜12:05

Chair Yukiko Gotoh(Laboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences,
The University of Tokyo)

SS-1 Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells
Shohei Furutachi and Yukiko Gotoh(Graduate School of Pharmaceutical Sciences, The University of Tokyo)
SS-2 The epidermal stem cell niche instructs the creation and positioning of mesenchymalfeatures
Hironobu Fujiwara(RIKEN Center for Developmental Biology)
SS-3 Melanocyte stem cells: a key for hair graying and melanoma
Emi K. Nishimura(Department of Stem Cell Biology, Medical Research Institute, Tokyo
Medical and Dental University)

12:05〜13:25

Lunch Time/Poster Session

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May 29 (Fri)-May 30 (Sat), 2015

Session 1: Hematopoietic & Neural Stem Cells

Chair Yoshihiro Takihara

13:25〜14:40(Department of Stem Cell Biology, Research Insitute for Radiation Biology andMedicine, Hiroshima University)

O-1 Disruption of Tsukushi function results aberrant neurogenesis in mouse brain.
Naofumi Ito, Riyadh MD Asrafuzzaman, Kunimasa Ohta
(Department of Developmental Neurobiology, Graduate School of Life
Sciences, Kumamoto University)
O-2 Manipulation of the Geminin activity by using cell-penetrating Geminin and its
domain-specific mutants
Yoshinori Ohno1, Shin’ichiro Yasunaga1,2 , Kyoko Suzuki-Takedachi1,
Toshiaki Kurogi1, Mimoko Santo1, Motoaki Ohtsubo3 , Kazuhito Naka1,4 ,Yoshihiro Takihara1(1Dept. Stem Cell Biol., RIRBM, Hiroshima Univ., 2Dept. Biochem., Facul.
Med., Fukuoka Univ., 3Dept. Food and Ferment. Sci., Beppu Univ., 4Explor.
Proj. Can. Stem Cells, CRI, Kanazawa Univ.)
O-3 Chromatin remodeling factor BRM is essential for maintaining HSC quiescence
Eriko Nitta1,2 , Masayuki Yamashita 2 , Motohiko Oshima1, Atsushi Iwama1,
Toshio Suda 2(1Chiba University Graduate School of Medicine, 2Keio University School of
Medicine)
O-4 Highly efficient Runx1 enhancer (eR1)-mediated genetic engineering for fetal andadult hematopoietic stem cells
Motomi Osato1,2 , Cai Ping Koh2 , Tomomasa Yokomizo1(1International Research Center for Medical Sciences, Kumamoto
University, 2Cancer Science Institute of Singapore, National University ofSingapore)O-5 Direct Activation of TLR4-TRIF-ROS-p38 Pathways Limits Hematopoietic Stem Cell
Fitness
Hitoshi Takizawa1, Kristin Fritsch2 , Yasuyuki Saito2 , Larisa V. Kovtonyuk2 ,Markus G. Manz2(1International Research Center for Medical Sciences, Kumamoto
University, 2Division of Hematology, University Hospital Zurich,
Switzeralnd)

14:40〜15:00

Coffee Break

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May 29 (Fri)-May 30 (Sat), 2015

15:00〜15:45

Session 2: Leukemia Stem Cells (1)Chair Shigeru Chiba(Department of Hematology, Faculty of Medicine, University of Tsukuba)

O-6 The clinical impact of both point mutated and alternatively spliced BCR-ABL in CML
patients: Result of highly-sensitive, deep sequencing study
Junichiro Yuda1, Toshimiro Miyamoto1, Jun Odawara1, Yasuyuki Ohkawa 2 ,Koichi Akashi1(1Medicine and Biosystemic Science, Kyushu University, Faculty of Medical
Sciences, 2Department of Advanced Medical Initiatives, Kyushu University,
Faculty of Medical Sciences)
O-7 Overexpression of the Shortest Isoform of Histone Demethylase LSD1 Primes
Hematopoietic Stem/Progenitor Cells for Malignant Transformation
Taeko Wada, Yusuke Furukawa(Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi
Med.Univ.)
O-8 Gene profiling analyses and mode of action in acute myeloid leukemia during
treatment with Hedgehog signaling inhibitor
Yosuke Minami(Division of Transfusion Medicine and Cell Therapy, Kobe University
Hospital)

15:45〜16:45

Session 3: Leukemia Stem Cells (2)Chair Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University)

O-9 Truncated Form EZH2 Mutation Promotes Myeloid Tumorigenesis in Mouse BMT
Model via Upregulation of Tumor Stem Cell Markers
Kimihito C. Kawabata1, Daichi Inoue1, Jiro Kitaura1, Yasutaka Hayashi1,
Tomofusa Fukuyama1, Hironori Harada 2 , Susumu Goyama1,
Toshio Kitamura1(1Division of Cell Therapy, Institute of Medical Science, the University ofTokyo, 2Department of Hematology, School of Medicine, Juntendo
University)
O-10 The roles of Glis2 in leukemic and hematopoietic stem cells
Emi Takamatsu-Ichihara, Haruko Shima, Shuhei Fujita,
Kazutsune Yamagata, Yukiko Aikawa, Issay Kitabayashi(Division of Hematological Malignancy, National Cancer Center ResearchInstitute)
O-11 Enhanced autophagy promotes survival of peripheral blast cells from murine MLLENL leukemia.
Yoshiki Sumitomo1,2 , Junji Koya1, Keisuke Kataoka1,
Takako Tsuruta-Kishino1, Morita Ken1, Tomohiko Sato1,3 ,Mineo Kurokawa1,4(1Department of Hematology & Oncology, Graduate School of Medicine,
The University of Tokyo, 2Oncology Research Laboratories, Kyowa Hakko
Kirin Co., Ltd., 3Department of Transfusion Medicine, The University ofTokyo Hospital, 4Department of Cell Therapy and Transplantation, The
University of Tokyo Hospital.)

5

13th Stem Cell Research SymposiumProteinase-activated receptor 1 (Par-1) inhibits proliferation but enhances leukemia
stem cell activity in MLL-fusion leukemia
Susumu Goyama 1, Mahesh Shrestha 2, Janet Schibler 2, Leah Rosenfeldt 2,
Whitney Miller 2, Eric OʼBrien 2, Benjamin Mizukawa 2, Toshio Kitamura 1,
Joseph S. Palumbo 2, James C. Mulloy 2(1Division of Cellular Therapy, The Institute of Medical Science, The
University of Tokyo, 2Division of Experimental Hematology and Cancer
Biology, Cincinnati Children's Hospital Medical Center, University ofCincinnati College of Medicine)Coﬀee BreakKeynote Lecture (2)Chair Koichi Akashi(Department of Medicine and Biosystemic Science, Faculty of Medicine, Kyushu
University)“Stem Cell Niche” – From Cells to Organs and Beyond
Hiromitsu Nakauchi(Stanford University / University of Tokyo)

General Meeting

Chief Director Koichi Akashi(Department of Medicine and Biosystemic Science, Faculty of Medicine, Kyushu
University)

Reception (Venue for Poster Presentation)

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May 29 (Fri)-May 30 (Sat), 2015

Saturday, May 30.

The Second Day
9:30〜10:10

Special Lecture: Metabolism & Stem Cells

Chair Atsushi Hirao(Cancer Research Institute, Kanazawa University)

S-1 Metabolic heterogeneity of cancer stem cells
Hideyuki Saya

(Keio University, School of Medicine, Institute for Advanced Medical
Research, Division of Gene Regulation)

Coffee Break

10:10〜10:30

Session 4: Metabolism & Stem Cells

10:30〜11:45

Chair Keiyo Takubo(Department of Stem Cell Biology, National Center for Global Health and Medicine)O-13 AMPK confers metabolic stress resistance to leukemia-initiating cells
Yusuke Saito1,2 , Daisuke Nakada1(1Molecular and Human Genetics, Baylor college of medicine, 2Division ofTumor and Cellular Biochemistry, Faculty of Medicine, University ofMiyazaki)
O-14 IDH mutants are promising therapeutic targets for acute myeloid leukemia
Yoko Ogawara1, Hironori Matsunaga 2 , Takahiko Seki2 , Yukino Machida1,
Kazushi Araki2 , Issay Kitabayashi1(1Division of Hematological Malignancy, National Cancer Center ResearchInstitute, 2R&D Division, Daiichi Sankyo Co., Ltd.)
O-15 Proliferation of transplanted hematopoietic stem cells is controlled by p38alphaactivated purine metabolism.
Daiki Karigane1,2 , Toshio Suda 3,4 , Keiyo Takubo1(1Department of Stem Cell Biology, Research Institute, National Center for
Global Health and Medicine, 2Division of Hematology, Department ofInternal Medicine, Keio University School of Medicine, 3Cancer Science
Institute, National University of Singapore, 4The International ResearchCenter for Medical Sciences (IRCMS), Kumamoto University)
O-16 Specific amino acid environment in bone marrow is crucial for the maintenance ofhematopoietic stem cells
Yuki Taya1, Satoshi Yamazaki1, Hiroshi Watarai1, Ayano Kanazawa1,
Yasunori Ota 2 , Takaho Endo3 , Hiromitsu Nakauchi1,4(1Laboratory of Stem Cell Therapy, Center for Experimental Medicine,
The Institute of Medical Science, University of Tokyo, 2Department of
Pathology, Research Hospital, The Institute of Medical Science, The
University of Tokyo, 3Laboratory for Integrative Genomics, RIKEN Center
for Integrative Medical Sciences, The institute of Physical and Chemical
Research, 4Institute for Stem Cell Biology and Regenerative Medicine,
Stanford University School of Medicine)7

13th Stem Cell Research Symposium

May 29 (Fri)-May 30 (Sat), 2015

O-17 Lactic acid bacteria-derived materials convert human fibroblasts to multipotential
cells
Kunimasa Ohta1, Kaoru Katou2 , Naofumi Ito1
(1Department of Developmental Neurobiology, Graduate Schoo of Life
Sciences, Kumamoto University, 2Biomedical Research Institute, National
Institute of Advanced Industrial Science and Technology (AIST))

Lunch Time/Poster Session

11:45〜12:45

Session 5: Cancer Stem Cells

12:45〜13:45

Chair Yohei Shimono(Division of Molecular and Cellular Biology, Kobe University Graduate School of
Medicine)

O-18 HER2/3-NF κ B-IGF2-ID1 circuit addiction as a fundamental mechanism forstabilization of the stemness of breast cancer cells in their niche
Kana Tominaga1,2 , Natsuko Kimura1, Takahiko Murayama1,
Yohei Shimono3 , Hideshi Ishii4 , Hideyuki Saya5, Masaki Mori6 ,Koichi Akashi7, Kei-ichiro Tada 8 , Arinobu Tojo1, Noriko Gotoh1,9(1Division of Molecular Therapy, Institute of Medical Science, University ofTokyo, 2JSPS DC2, 3Division of Molecular and Cellular Biology, Kobe
University, Graduate School of Medicine, 4Department of Cancer Profiling
Discovery, Osaka University Graduate School of Medicine, 5Division ofGene Regulation, Institute Advanced Medicine Research, Graduate Schoolof Medicine, Keio University, 6Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University, 7Department of Medicine
and Biosystemic Science, Graduate School of Medicine, Kyusyu Univesity,
8
Department of Breast & Endocrine Surgery, Graduate School of Medicine,
University of Tokyo, 9Division of Cancer Cell Biology, Cancer ResearchInstitute, Kanazawa University)
O-19 Epithelial to mesenchymal transition by TGF-beta treatment enhances sphere
forming ability in primary colorectal cancer
Michitaka Nakano1, Hiroshi Ariyama1, Shingo Tamura1, Taichi Isobe1,
Kohta MIyawaki1, Yuta Okumura1, Hitoshi Kusaba1, Takashi Ueki2 ,Eishi Baba1, Koichi Akashi1(1Medicine and Biosystemic Science, Kyushu University, 2Surgery andOncology, Kyushu University)
O-20 miR-142 Upregulates miR-150 and Confers an Aberrant Proliferative Ability to
Human Breast Cancer Stem Cells.
Yohei Shimono1, Taichi Isobe2 , Shigeo Hisamori3 , Michael Clarke2(1Kobe University Graduate School of Medicine, 2Institute for Stem Cell
Biology and Regenerative Medicine, Stanford University, U.S.A., 3Kyoto
University Graduate School of Medicine.)

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O-21 CD74-NRG1 is a potential oncoprotein that promotes cancer stem cell properties.
Takahiko Murayama1,2 , Takashi Nakaoku3 , Koji Tsuta4 , Masato Enari5,
Tatsunori Nishimura6 , Kana Tominaga6 , Asuka Nakata1, Arinobu Tojo7,
Sumio Sugano2 , Takashi Kohno3 , Noriko Gotoh1,6(1Division of Cancer Cell Biology, Cancer Research Institute of Kanazawa
University, 2Laboratory of Functional Genomics, Department of Medical
Genome Sciences, Graduate School of Frontier Sciences, University ofTokyo, 3Division of Genome Biology, National Cancer Center ResearchInstitute, 4Pathology Division, National Cancer Center Research Institute,
5
Division of Refractory Cancer Research, National Cancer Center ResearchInstitute, 6Division of Molecular Therapy, Molecular targets laboratory,
Institute of Medical Science, University of Tokyo, 7Division of Molecular
Therapy, Advanced Clinical Research Center, Institute of Medical Science,
University of Tokyo)

13:45〜14:30

Session 6: Hematopoiesis

Chair Motomi Osato(International Research Center for Medical Sciences, Kumamoto University)

O-22 A single micro-RNA can completely rescue B-cell differentiation arrest due to EBF1
deficiency—Can miR-195 control cell fate more than a fine tuner?
Bidisha Chanda1, Tomokatsu Ikawa 2 , Kazuki Okuyama1, Katsuto Hozumi3 ,Kiyoshi Ando4 , Arinobu Tojo5, Hiroshi Kawamoto6 , Ai Kotani1(1Division of Hematological Malignancy, Institute of Medical Science, Tokai
University, 2RIKEN Research Center for Allergy and Immunology,3
Depertment of Immunology, Tokai University Medical School,
4
Department of Hematology, Tokai University, 5Division of Molecular
Therapy, Institute of Medical Science, University of Tokyo, 6Depertment of
Immunology, Kyoto University)
O-23 Modulation of macrophages by tumor-derived secretory small RNAs is critical for
EBV lymphoma formation
Natsuko Yamakawa1, Ken-Ichi Imadome2 , Takashi Yahata 3 , Ai Kotani1(1Department of Hematological Malignancy, Institute of Medical Science,
Tokai University, 2Department of Infectious Diseases, National Center forChild Health and Development, 3Research Center for Cancer Stem Cell,
Tokai University School of Medicine)O-24 A novel 2 amino acids deletion of the transcription factor C/EBP epsilon leads toneutrophil-specific granule deficiency (SGD).
Tadayuki Akagi1, Taizo Wada 2 , Masahiro Muraoka 2 , Tomoko Toma 2 ,Kenzo Kaji3 , Kazunaga Agematsu4 , H. Phillip Koeffler5, Takashi Yokota1,
Akihiro Yachie2(1Department of Stem Cell Biology, Graduate School of Medical Sciences,
Kanazawa University, 2Department of Pediatrics, Graduate School of
Medical Sciences, Kanazawa University, 3Department of Dermatology,
Komatsu Municipal Hospital, 4Department of Infection and Host Defense,
Shinshu University Graduate School of Medicine, 5Cancer Science Instituteof Singapore, National University of Singapore, Singapore)

14:30〜14:50

Coffee Break9

13th Stem Cell Research Symposium

May 29 (Fri)-May 30 (Sat), 2015

Session 7: Multi-/pluri-potent Stem Cells 1

Chair Takumi Era

14:50〜15:35(Department of Cell Modulation, IMEG, Kumamoto University)

O-25 Dynamic expression patterns of Pax6 during spermatogenesis in the mouse
Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi(Department of Developmental Neuroscience, Center for Neuroscience,
Tohoku University School of Medicine.)
O-26 OVOL2 controls transcriptional programs of ectodermal lineage
Shinji Masui1, Koji Kitazawa1, Shigeru Kinoshita 2(1Center for iPS Cell Research and Application, Kyoto University,2
Department of Ophthalmology, Kyoto Prefectural University of Medicine.)
O-27 Actin regulates cellular reprogramming
Takashi Ikeda, Takafusa Hikichi, Akira Watanabe, Akitsu Hotta,
Shinji Masui(Department of Reprogramming Science, Center for iPS Research andApplication (CiRA), Kyoto University)

Session 8: Multi-/pluri-potent Stem Cells 2

Chair Shinji Masui

15:35〜16:20(Center for iPS Cell Research and Application, Kyoto University)

O-28 A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T-Cell
Therapy
Miki Ando1, Toshinobu Nishimura 2 , Satoshi Yamazaki1, Malcolm Brenner3 ,Hiromitsu Nakauchi1,2(1Division of Stem Cell Therapy, Center for Stem Cell Biology andRegenerative Medicine, The Institute of Medical Science, The Universityof Tokyo, 2Institute for Stem Cell Biology and Regenerative Medicine,
Stanford University, 3Center for Cell and Gene Therapy, Baylor College ofMedicine)
O-29 A newly effective drug candidate was found using iPS cell derived from NiemannPick disease type C
Minami Soga1, Yoichi Ishitsuka 2 , Makoto Hamasaki1, Kaori Yoneda3 ,Hirokazu Furuya4 , Muneaki Matsuo5, Hironobu Ihn6 , Noemi Fusaki7,
Kimitoshi Nakamura3 , Naomi Nakagata 8 , Fumio Endo3 ,Tetsumi Irie2 , Takumi Era1
(1Department of Cell Modulation, Institute of Molecular Embryology andGenetics, Kumamoto University, 2Department of Clinical Chemistry andInformatics, Graduate School of Pharmaceutical Sciences, Kumamoto
University, 3Department of Pediatrics, Graduate School of Medical
Sciences, Kumamoto University, 4Department of Cardiology, Neurology
and Aging Science, Kochi University Medical School, 5Department ofPediatrics, Saga University, Faculty of Medicine, 6Department of
Dermatology and and Plastic Surgery, Faculty of Life Sciences, Kumamoto
University, 7Department of Ophthalmology, Keio University School of
Medicine, 8Division of Reproductive Engineering, Center for Animal
Resources and Development, Kumamoto University.)

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May 29 (Fri)-May 30 (Sat), 2015

O-30 New Type of Sendai Virus Vector Provides Transgene-Free iPS Cells Derived from
Chimpanzee Blood
Makoto Hamasaki1, Yasumitsu Fujie1, Noemi Fusaki2,3 ,Tomohiko Katayama1, Yumi Soejima1, Minami Soga1, Hiroshi Ban2 ,Mamoru Hasegawa 2 , Satoshi Yamashita4 , Shigemi Kimura5, Saori Suzuki6 ,Tetsuro Matsuzawa7, Hirofumi Akari6,8 , Takumi Era1
(1Department of Cell Modulation, Institute of Molecular Embryology andGenetics, Kumamoto University, 2DNAVEC Corporation, 3Department ofOphthalmology, Keio University School of Medicine, 4Department of
Neurology, Graduate School of Medical Sciences, Kumamoto University,
5
Department of Child Development, Graduate School of Medical Sciences,
Kumamoto University, 6Section of Comparative Microbiology and
Immunology, Center for Human Evolution Modeling Research, Primate
Research Institute, Kyoto University, 7Section of Language andIntelligence, Primate Research Institute, Kyoto University, 8Laboratory of
Evolutional Virology, Experimental Research Center for Infectious
Diseases, Institute for Virus Research, Kyoto University)

16:20〜16:30

Closing Remarks

Next Organizer Atsushi Hirao(Cancer Research Institute, Kanazawa University)

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13th Stem Cell Research Symposium

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Poster Session
P-1

Functional analysis of neurodevelopmental disorder causative protein MeCP2 inneural stem cells
Keita Tsujimura, Hideyuki Nakashima, Koichiro Irie, Kinichi Nakashima(Stem Cell Biology and Medicine, Department of Stem Cell Biology andMedicine, Graduate School of Medical Science, Kyushu University)

P-2

Identification of a potential progenitor cell population of bile duct epithelial cells withclonal proliferation activity in regenerating mouse liver
Kenji Kamimoto, Tohru Itoh, Atsushi Miyajima(IMCB, The University of Tokyo, Department of Biophysics andBiochemistry, the University of Tokyo)

P-3

Characterization of Liver Stem/Progenitor Cell by the Expression Profile of Lutheran
Yasushi Miura1, Minoru Tanaka 2 , Yamato Kikkawa3 , Nobuhito Goda1,
Atsushi Miyajima4(1Department of Life Science and Medical Bioscience, School of Scienceand Engineering, Waseda University, 2Department of Regenerative
Medicine, Research Institute of National Center for Global Health andMedicine, 3Laboratory of Clinical Biochemistry, Tokyo University of
Pharmacy and Life Sciences, 4Laboratory of Cell Growth andDifferentiation, Institute of Molecular and Cellular Biosciences, The
University of Tokyo)

P-4 Roles of metabolic signals in differentiation and de-differentiation of mouse primordial
germ cells
Yuki Yoshimura1, Mizuki Wakabayashi1, Shigeyuki Nada 2 , Masato Okada 2 ,Yoichi Sekita1, Tohru Kimura1(1Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato
University School of Science, 2Department of Oncogene Research,
Research Institute for Microbial Diseases, Osaka University)
P-5 Identification of mouse Biliary Tree Stem/Progenitor Cell (BTSC) based on TROP2
expression profile.
Satoshi Matsui1,2 , Minoru Tanaka1,2 , Atsushi Miyajima1(1Laboratory of Cell Growth and Differentiation, Institute of Molecular andCellular Biosciences (IMCB), The University of Tokyo., 2Dept. ofRegenerative Medicine, National Center for Global Health and Medicine(NCGM).)
P-6 Locus-specific expansion of Polycomb domain determines the temporal repression of
the neurogenic genes in neocortical development
Yusuke Kishi1, Yusuke Hirabayashi2 , Kelsey Tyssowski2 , Haruhiko Koseki3 ,Yutaka Suzuki4 , Yukiko Gotoh1(1Grad Sch Pharma, Univ of Tokyo, 2IMCB, Univ of Tokyo, 3RIKEN, IMSRCAI, 4Grad Sch Frontier Sci, Univ of Tokyo)
P-7

Sp1/3 sustain self-renewal of Embryonic stem cell through regulating core Klf
circuitry
Hiroki Ura(RIKEN Center for Developmental Biology)

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P-8

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells
Shohei Furutachi, Yukiko Gotoh(Graduate School of Pharmaceutical Sciences, The University of Tokyo)

P-9 Investigation of the lower c-kit expressing cells in murine hematopoietic stem cellcompartment
Yutaka Sasaki, Yoshikazu Matsuoka, Ryusuke Nakatsuka,
Keisuke Sumide, Hiroshi Kawamura, Tatsuya Fujioka, Sonoda Yoshiaki(Department of Stem Cell Biology and Regenerative Medicine, Graduate
School of Medical Science, Kansai Medical University)
P-10 Role of the Polycomb Gene Bcor in Hematopoiesis
Tomoyuki Tanaka1,2 , Sha Si3 , Shiro Tara3 , Atsunori Saraya 3 ,Yaeko Nakajima-Takagi4 , Hirohito Sone4 , Haruhiko Koseki5,
Atsushi Iwama 3(1Department of Hematology, Endocrinology and Metabolism, Niigata
University, 2Department of Cellular and Molecular Medicine, Graduate
School of Medicine, Chiba University, 3Department of Cellular andMolecular Medicine, Graduate School of Medicine, Chiba University,
4
Department of Hematology, Endocrinology and Metabolism, Niigata
University, 5Laboratory for Developmental Genetics, RIKEN ResearchCenter for Integrative Medical Sciences, IMS.)
P-11 Quality control of undifferentiated status in hematopoietic stem cells during cell
division by Spred1
Yuko Tadokoro1, Akihiko Yoshimura 2 , Hiromitsu Nakauchi3 ,Atsushi Hirao1(1Division of Molecular Genetics, Cancer Research Institute, Kanazawa
University, 2Department of Microbiology and Immunology, Keio University
School of Medicine, 3Division of Stem Cell Therapy, The Institute ofMedical Science, The University of Tokyo)
P-12 Maintenance of intra-aortic hematopoietic cell clusters in the AGM region throughthe Sox17-Notch1-Hes1 axis
Kiyoka Saito, Ikuo Nobuhisa, Maha Anani, Kaho Harada,
Satomi Takahashi, Tetsuya Taga
(Department of Stem Cell Regulation, Medical Research Institute, Tokyo
Medical and Dental University (TMDU))
P-13 Exo-utero surgical technique enables us to investigate hematopoietic homing fromfetal liver to bone marrow.
Yuka Tanaka1,2 , Tomoko Inoue3 , Kasem Kulkeaw3 , Chiyo Yanagi2 ,Keai Sinn Tan3 , Naoko Kojima 3 , Anthony Swain3 , Senji Shirasawa 2 ,Yoichi Nakanishi4 , Daisuke Sugiyama1,5(1Center for Advanced Medical Innovation, Kyushu University,2
Department of Cell Biology, Faculty of Medicine, Fukuoka University,
3
Department of Research and Development of Next Generation Medicine,
Kyushu University Faculty of Medical Sciences, 4Center for Clinical andTranslational Research, Kyushu University Hospital, 5Center for Clinicaland Translational Research, Kyushu university Hospital)

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P-14 Role of UTX, a histone H3K27 demethylase, in normal hematopoiesis and hematologic
malignancies
Yasuyuki Sera1, Takeshi Ueda1, Yuichiro Nakata1, Ken-ichiro Ikeda1,
Norimasa Yamasaki1, Hideaki Oda 2 , Zen-ichiro Honda3 , Hiroaki Honda1(1Department of Disease Model, Research Institute for Radiation Biology
and Medicine, Hiroshima University, 2Department of Pathology, Tokyo
Women’s Medical University, 3Health Care Center and Graduate School of
Humanities and Sciences, Institute of Environmental Science for Human
Life, Ochanomizu University)
P-15 A transient treatment of GSK3β inhibitor enhances hematopoietic differentiation ofhuman pluripotent stem cells.
Kenji Kitajima1, Marino Nakajima1,2 , Mai Kanokoda1,2 , Takahiko Hara1,2(1Stem Cell project, Tokyo Metropolitan Institute of Medical Science,2
Graduate School of Medical and Dental Sciences, Tokyo Medical and
Dental University)
P-16 Induction of the megakaryocyte differentiation from mouse/human pluripotent stem
cells by Gata transcription factors
Mai Kanokoda1,2 , Kenji Kitajima1, Manami Kawaguchi1,2 ,Marino Nakajima1,2 , Michael Kyba 3 , Takahiko Hara1,2(1Stem Cell project, Tokyo Metropolitan Institute of Medical Science,2
Graduate School of Medical and Dental Sciences, 3Lillehei Heart Institute,
University of Minnesota)
P-17 Full hematopoietic differentiation potentials of tetraploid pluripotent stem cells
generated by cell fusion between mouse T cells and embryonic stem cells
Marino Nakajima1,2 , Kenji Kitajima1, Mai Kanokoda1,2 , Takahiko Hara1,2(1Stem Cell project, Tokyo Metropolitan Institute of Medical Science,2
Graduate School of Medical and Dental Sciences, Tokyo Medical and
Dental University)
P-18 Promotion of iPS cell induction by AKT signaling activation
Eriko Kanai, Toshihisa Haraoka, Yuki Yoshimura, Keita Fujikawa,
Yoichi Sekita, Tohru Kimura(Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato
University School of Science.)
P-19 Zfp296 associates with Klf4 and regulates its activity as an activator and a repressor.
Yuka Fujii, Tadayuki Akagi, Takashi Yokota(Department of Stem Cell Biology, Graduate School of Medical Sciences,
Kanazawa University)
P-20 Dynamic regulation of colon tumor-derived stem cells demonstrated by single-cell
qPCR
Daisuke Shiokawa, Hirokazu Ohata, Koji Okamoto(Division of Cancer Differentiation, National Cancer Center ResearchInstitute)

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P-21 Estrogen induces proliferation of breast cancer stem cells via NO/sGC/cGMP
signaling pathway
Naoya Hirata1, Yosuke Demizu2 , Masaaki Kurihara 2 , Yuko Sekino1,
Yasunari Kanda1(1Div. Parmacol., NIHS, 2Div. Org. Chem., NIHS)
P-22 The roles of p62/SQSTM1, an adaptor protein for selective autophagy, for stemnessof breast cancer cells
Chiaki Ito, Noriko Gotoh(Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa
University)
P-23 GDF15 promotes mammosphere formation in breast cancer
Asako Sasahara1, Tominaga Kana1, Arinobu Tojo1, Noriko Gotoh2,3(1Division of Molecular Therapy, Institute of Medical Science, University ofTokyo, 2Division of Molecular Therapy, Institute of Medical Science,
University of Tokyo, 3Division of Cancer Cell Biology, Cancer ResearchInstitute, Kanazawa University)
P-24 Notch3 regulates the quiescence of neural stem cells in the adult mouse
subependymal zone
Hiroki Kawai, Shohei Furutachi, Yukiko Gotoh(Laboratory of Molecular Biology, Graduate School of Pharmaceutical
Sciences, The University of Tokyo)
P-25 Distinctive Thy1-expressing mesenchymal cells contribute to hepatic tissue
remodeling in mouse models of cholestatic liver injury
Len Katsumata, Tohru Itoh, Atsushi Miyajima(Laboratory of Cell Growth and Differentiation, Institute of Molecular andCellular Biosciences, The University of Tokyo)
P-26 Dppa3 accelerates erythroid differentiation accompanied with globin synthesis in themouse fetal liver
Kasem Kulkeaw1, Daisuke Sugiyama 2 , Tomoko Inoue1, Naoko Kojima1,
Anthony Swain1, Muttika Madtookung1, Kaori Takakusagi3 , Yuka Tanaka1,
Akane Yonehara 3(1Department of Research and Development of Next Generation Medicine,
Faculty of Medical Sciences, Kyushu University, 2Department Head,
Professor Department of Clinical Study Center for Advanced Medical
Innovation Kyushu University, 3International Cooperation Unit Center for
Clinical and Translational Research Kyushu University Hospital)
P-27 Apoptosis inducing factor 2 functions in erythropoiesis by regulating Klf1 gene andenucleation related genes in mouse erythro-leukemic cells
Naoko Kojima1, Kasem Kulkeaw2 , Tomoko Inoue2 , Yuka Tanaka3 ,Keai Sinn Tan2 , Anthony Swain2 , Muttika Madtookung2 , Yoichi Nakanishi4 ,Senji Shirasawa1, Daisuke Sugiyama 3(1Department of Cell Biology, Faculty of Medicine, Graduate school of
Fukuoka University, 2Department of Research and Development of Next
Generation Medicine, Faculty of Medical Sciences, Kyushu University,
3
Department of Clinical Study, Center for Advanced Medical Innovation,
Kyushu University, 4Center for Clinical and Translational Research,
Kyushu University Hospital)

15

13th Stem Cell Research Symposium