May 13 (Fri)-14(Sat), 2011

The 9th Stem Cell Research Symposium
Program

Date： May 13 (Fri) - 14(Sat), 2011

Venue

： Izumi Garden Gallery

Director ：Mineo Kurokawa
Department of Hematology and Oncology, Graduate School of
Medicine, University of Tokyo

Organizer ：Stem Cell Research Symposium
Cosponsor：Tokyo University Global COE Program
Comprehensive center of education and research forchemical biology of the diseases

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9th Stem Cell Research Symposium

May 13 (Fri)-14(Sat), 2011

Friday, May 13.

The First Day

Registration・Exhibit posters
Opening Remarks

Director

9:00～9:50
Mineo Kurokawa

9:50～10:00(Department of Hematology and Oncology, Graduate School of Medicine,
University of Tokyo)

Session 1：ES cells/iPS cells (I)Chair Atsushi Miyajima

10:00～11:20(Institute of Molecular and Cellular Biosciences, The University ofTokyo)
O-1

Induction of primordial germ cell-like cells from mouse embryonic stem cellsby manipulation of signaling pathways
Tohru Kimura1, Mitinori Saitou2, Takashi Shinohara3, Toru Nakano2（1 Gradual School of Frontier Biosciences, Department of Pathology, Medical
School, Osaka University , 2 Department of Anatomy and Cell Biology, 3
Department of Molecular Genetics, Graduate School of Medicine, Kyoto
University）

O-2

Involvement of nuclear hormone receptors Dax1 and Esrrb in themaintenance of self-renewal in ES cells
Kousuke Uranishi, Tadayuki Akagi, Chuanhai Sun, Hiroshi Koide,
Takashi Yokota(Department of Stem Cell Biology, Graduate School of Medical Science,
Kanazawa University)

O-3

LIF/STAT3 signaling is regulated by LacdiNAc (GalNAcβ1–4GlcNAc) glycan
structures on mouse embryonic stem cells
Norihiko Sasaki, Kazumi Hirano, Shoko Nishihara(Laboratory of Cell Biology, Department of Bioinformatics, Faculty ofEngineering, Soka University)

O-4

Generation of induced pluripotent stem cells from primary hematologicalmalignancies and search for the novel targeted therapy
Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Koki
Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, and Mineo Kurokawa.
(Department of Hematology and Oncology, Graduate School of Medicine,
University of Tokyo)

Coffee Break9th Stem Cell Research Symposium

11:20～11:40

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May 13 (Fri)-14(Sat), 2011

Special Lecture 1
Chair Keiya Ozawa

11:40～12:20(Division of Hematology, Department of Medicine, Jichi Medical University )Role of an RNA binding protein Musashi in stem cells and cancer
development
Takahiro Ito1,2, Tannishtha Reya1(1Department of Pharmacology, University of California San Diego;
2Interdisciplinary Stem Cell Training Program, California Institute ofRegenerative Medicine)Lunch time

12:20～13:40（Secretary society

12:20～13:40）

Poster Session

13:40～14:40

Coffee Break

14:40～15:00

Session 2: Somatic stem cells
Chair Tetsuya Taga

15:00～16:00(Department of Stem Cell Regulation, Medical Research Institute, Tokyo
Medical and Dental University)
O-5

Tsukushi is involved in the neuronal stem/progenitor cells proliferation as a
Wnt signalling inhibitor
Kunimasa Ohta1, Ayako Ito1,2, Yohei Shinmyo1, Naoko Kaneko3, Yuki
Hirota3, Masahiro Yamaguchi4, Kazunobu Sawamoto3, Hideaki
Tanaka1,2(1Graduate School of Medical Sciences, Kumamoto University, 2Global COE,
Kumamoto University, Institute of Molecular Medicine, 3Nagoya City
University Graduate School of Medical Sciences, 4Graduate School of Medical
science, University of Tokyo,)O-6

FGF’7 is a functional niche signal required for stimulation of adult liverprogenitor cells that support liver regeneration
Tohru Itoh, Hinako Takase, and Atsushi Miyajima(Institute of Molecular and Cellular Biosciences, The University of Tokyo)

O-7

Identification of eccrine gland melanocyte stem cells in mouse acral skin as
a potential source of acral melanoma
Natsuko Okamoto1, Takahiro Aoto2, Yoshiki Miyachi1, Emi K.
Nishimura2(1Department of Dermatology, Kyoto University Graduate School of Medicine,
Kyoto, Japan. 2Department of Stem Cell Biology, Medical Research Institute,Tokyo Medical and Dental University, Tokyo, Japan)

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9th Stem Cell Research Symposium

May 13 (Fri)-14(Sat), 2011

Coffee Break

16:00～16:20

Session 3: Hematopoietic stem cells (I)Chair
Kiyoshi Ando

16:20～17:20(Division of Hematology/Oncology, Department of Internal Medicine, Tokai
University School of Medicine)
O-8

Characterization of Runx1+ lateral mesodermal progenitors in the earlymouse embryo
Yosuke Tanaka, Shin-ichi Nishikawa(RIKEN CDB Laboratory for Stem Cell Biology)

O-9

A new immunodeficient mouse model introduced with defined Sirpa
polymorphism for human hematopoietic stem cell assay
Takuji Yamauchi1, Shingo Urata1, Katsuto Takenaka1, Yoshikane
Kikushige1, Toshihiro Miyamoto1, Koichi Akashi1,2(1Department of Medicine and Biosystemic Science, Kyushu University
Graduate School of Medical Sciences, Fukuoka, 2Centre for Cellular andMolecular Medicine, Kyushu University Hospital, Fukuoka, Japan）

O-10

Dependency on the polycomb gene Ezh2 distinguishes fetal from adulthematopoietic stem cells
Makiko Mochizuki-Kashio, Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University)

General Meeting

Chief Director

Toshio Suda

17:20～17:40(Department of Cell Differentiation, Keio University School of Medicine)

9th Stem Cell Research Symposium

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May 13 (Fri)-14(Sat), 2011

Saturday, May 14.

The Second Day

Session 4: Cancer stem cell
Chair Atushi Hirao

9:00～10:40(Division of Molecular Genetics, Cancer and Stem Cell Research
Program, Cancer Research Institute, Kanazawa University)
O-11

Fibrotic tissues in human primary myelofibrosis are derived from malignant
hematopoietic stem cells
Takahiro Shima1, Noriyuki Saito1, Takuji Yamauchi1, Yoshikane
Kikushige1, Fumihiko Ishikawa2, Koichi Akashi1(1Medicine and Biosystemic Science, Kyushu University, 2Research Unit for
Human Disease Models, RIKEN Research Center for Allergy and Immunology)

O-12

Bone marrow-derived myofibroblasts contribute to the mesenchymal stem
cell niche and promote tumor growth.
Shigeo Takaishi1,2, Quante Michael3, Shuiping Tu3, Hiroyuki Tomita3,
Tamas Gonda3, Wataru Shibata3, Sophie S.W. Wang3, Gwang Ho Baik3,
Kelly S. Betz3, Benjamin Tycko3, Timothy C. Wang3, Koichi Akashi1,2.
(1 Department of Cell Therapy and Regenerative Medicine,Center for Advanced
Medical Innovation, 2 Department of Medicine and Systemic Bioscience, Schoolof Medicine, Kyushu University, Fukuoka, Japan ,3 Division of Digestive andLiver Disease, Department of Medicine, Columbia University, New York, USA.)

O-13

Combination of a Ptgs2 inhibitor and an EGFR-signaling inhibitor prevents
tumorigenesis of oligodendrocyte-lineage derived glioma-initiating cells.
Takuichiro Hide1,2, Tatsuya Takezaki1,2, Yuka Nakatani1, Hideo
Nakamura2, Jun-ichi Kuratsu2 and Toru Kondo1,3(1 Laboratory for Cell Lineage Modulation, Center for Developmental Biology,
RIKEN, Kobe 650-0047, Japan, 2 Department of Neurosurgery, Kumamoto
University Graduate School of Medical Science, Kumamoto 860-8556, Japan ,3Department of Stem Cell Biology, Ehime University Proteo-Medicine
Research Center, To-on, Ehime 791-0295, Japan.)

O-14

Treatment with mTOR inhibitors, everolimus and BEZ235 overcomes
resistance to imatinib in BCR-ABL-positive leukemia quiescent cells
Yosuke Minami, Yachiyo Kuwatsuka, Miho Minami and Tomoki Naoe
(Department of Hematology and Oncology, Nagoya University Graduate Schoolof Medicine)O-15

EGF receptor/ ErbB-NFkB signaling for self-renewal of breast cancer stem
cells
Kunihiko Hinohara1, Seiichiro Kobayashi2, Kazuo Umezawa3, Arinobu
Tojo2, Jun-ichiro Inoue4, Hajime Kanauchi5, Toshihisa Ogawa6, Noriko
Gotoh1(1Division of Systems Biomedical Technology, Institute of Medical Science,
University of Tokyo, 2Division of Molecular Therapy, Advanced ClinicalResearch Center, Institute of Medical Science, University of Tokyo,
3Department of Applied Chemistry, Faculty of Science and Technology, Keio
University, 4Division of Cellular and Molecular Biology, Institute of Medical
Science, University of Tokyo, 5Department of Breast and Endocrine Surgery,Showa General Hospital, 6Department of Breast and Endocrine Surgery,
Graduate School of Medicine, The University of Tokyo)

Coffee Break

10:40～11:00

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9th Stem Cell Research Symposium

May 13 (Fri)-14(Sat), 2011

Special Lecture 2
Chair Yusuke Furukawa

11:00～11:40(Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi
Medical University School of Medicine, Tochigi, Japan)

Systems Approach to Stem Cell Biology
Jun Seita, M.D. Ph.D.
(Institute for Stem Cell Biology and Regenerative Medicine, Stanford
University)

Lunch time

11:40～13:00

Poster Session

13:00～14:00

Session 5: ES cells/iPS cells (II)
Chair Takumi Era

14:00～15:20(Department of Cell Modulation, Institute of Molecular Embryology andGenetics, Kumamoto University)
O-16

Eed/Sox2 regulatory loop controls ES cell self-renewal through histone
methylation and acetylation
Hiroshi Koide1, Hiroki Ura1, Kazuhiro Murakami2, Tadayuki Akagi1,
Keita Kinoshita1, Shukuro Yamaguchi1, Shinji Masui3, Hitoshi Niwa2,
Takashi Yokota1(1Department of Stem Cell Biology, Graduate School of Medical Science,
Kanazawa University, 2Laboratory for Pluripotent Cell Studies, RIKEN Center
for Developmental Biology, 3Division of Molecular Biology and Cell
Engineering, Department of Regenerative Medicine, International Medical
Center of Japan)

O-17

H2A ubiquitination is an essential step to mediate PRC1 Polycomb silencing
of differentiation genes in ES cells
Mitsuhiro Endoh, Haruhiko Koseki(Laboratory for Developmental Genetics, RIKEN Research Center for Allergy
and Immunology)

O-18

Ground state condition renders Myc activity redundant in ES cells for theirindefinite self-renewal
Tomoaki Hishida, Akihiko Okuda(Division of Developmental Biology, Research Center for Genomic Medicine,
Saitama Medical University)

O-19

Differentiation of functionally mature eosinophils from human embryonicand induced pluripotent stem cells
Feng MA, Wenyu YANG, Yanzheng GU, Hiromitsu NAKAUCHI,
Kohichiro TSUJI(Division of Stem Cell Processing and Stem Cell Therapy, Center for Stem Cell
Biology and Regenerative Medicine, Institute of Medical Science, University ofTokyo)

9th Stem Cell Research Symposium

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May 13 (Fri)-14(Sat), 2011

Coffee Break

15:20～15:40

Session 6: Hematopoietic stem cells (II)
Chair Yoshiaki Sonoda

15:40～16:40(Department of Stem Cell Biology and Regenerative Medicine, Graduate
School of Medical Science, Kansai Medical University)
O-20

Latexin Regulates the Abundance of Multiple Cellular Proteins in
Hematopoietic Stem Cells
Kanae Mitsunaga, Jiro Kikuchi, Taeko Wada, and Yusuke Furukawa(Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi
Medical University School of Medicine, Tochigi, Japan)

O-21

A protective metabolic program in hematopoietic stem cells
Keiyo Takubo, Toshio Suda
(Department of Cell Differentiation, The Sakaguchi
Developmental Biology, Keio University School of Medicine)

O-22

Laboratory

of

BAALC regulates hematopoietic stem cells through p53 and promotes
leukemia with impaired p53 function
Sumimasa Nagai, Keiki Kumano, Akihito Shinohara, Masahiro
Nakagawa, Motoshi Ichikawa, Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine,
University of Tokyo)

Closing Remarks

Next Director

Toshio Suda

16:40～(Department of Cell Differentiation, Keio University School of Medicine)7

9th Stem Cell Research Symposium

May 13 (Fri)-14(Sat), 2011

Poster Session（Gallery B）
Friday, May 13
Saturday, May 14
P-1

13:40～14:40
13:00～14:00

Identities arising during mesoderm differentiation
Martin Jakt, Satoko Moriwaki, Shinichi Nishikawa( Stem Cell Biology Group, Riken Center for Developmental Biology, Kobe

P-2

Establishment of embryonic stem-like cells from bovine blastocysts in vitro
Manabu Ozawa1,2, Nobuaki Yoshida2 and Peter J. Hansen1(1Department of Animal Sciences, University of Florida, 2Institute of Medical
Science, University of Tokyo)

P-3

Cell cycle regulation of embryonic stem cells by RNA binding protein PTB
Satona Ohno, Masaki Shibayama, Nobuaki Yoshida(Center for Experimental Medicine and Systems Biology, Institute of Medical
Science, Tokyo University)

P-4

Cell cycle regulation of mouse embryonic stem cells
Hisao Masai1, Hiroko Fujii1, Yutaka Kanoh1, Sayuri Ito1, Naoko
Kakusho1, Asako Sawano2, and Atsushi Miyawaki2(1Genome Dynamice Project, Tokyo Metropolitan Institute of Medical Science
2-1-6 Kamikitazawa, Setagaya-ku, Tokyo156-8506; 2Laboratory for Cell
Function and Dynamics, Advanced Technology Development Group, Brain
Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198)

P-5

Nanog regulates anchorage-independent growth of HT1080 fibrosarcoma
cells
Yuhki Tada, Tadayuki Akagi, Takashi Yokota, Hiroshi Koide(Dept. of Stem Cell Biology, Grad. Sch. of Med. Sci., Kanazawa Univ.)

P-6

Hematopoietic differentiation of human iPS cells induced by forced
expression of hematopoietic key regulators.
Mitsujiro Osawa1,2, Yaeko Nakajima1,2, Motohiko Oshima1,2, Haruna
Takagi1, Atsushi Iwama1,2(1Department of Cellular and Molecular Medicine, Graduate School of
Medicine, Chiba University, 2JST/CREST)

P-7

In vivo analyses of mouse iPSC-derived HSC-like cells generated byenforced expression of LIM-homeobox transcription factor Lhx2.
Kenji Kitajima, Takahiko Hara
(Stem Cell Project, Tokyo Metropolitan Institute of Medical Science)

P-8

Establishment of mouse induced pluripotent stem cells expressing HNF3β
in a tetracycline-regulated fashion to induce hepatic differentiation
Yuta Tetsuka1, Gana Adyaksa1, Yoshiaki Matsumi1, Yoshiko
Hoshikawa1, Satsuki Miyazaki2, Jun-ichi Miyazaki2, and Goshi Shiota1(1Division of Molecular and Genetic Medicine, Graduate School of Medicine,
Tottori University, 2Division of Stem Cell Regulation Research, Graduate
School of Medicine, Osaka University)

9th Stem Cell Research Symposium

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May 13 (Fri)-14(Sat), 2011

P-9

The generation of porcine iPS cells with characters similar to those of mouse
ES cells
Yoshihisa Mizukami1, Shuh-hei Fujishiro1, Rikiya Ishino1, Yutaka
Furukawa1, Takashi Nishimura1,2, Hitomi Matsunari3, Kazuaki
Nakano3, Hiroshi Nagashima3, Yutaka Hanazono1,4(1Division of Regenerative Medicine, Center for Molecular Medicine, Jichi
Medical University, 2Fuji Micra Incorporated, 3Department of Life Sciences,
School of Agriculture, Meiji University, 4JST, CREST)

P-10

Generation of induced pluripotent stem cells from the patients withintractable diseases
Tomomi Towata1, Yoshinori Yamada1, Noemi Fusaki2, Takumi Era1
(1Department of Cell Modulation, Institute of Molecular Embryology andGenetics, Kumamoto University, 2DNAVEC Corporation)

P-11

Analysis of PTB-dependent alternative splicing switch during neuraldevelopment
Akinori Tokunaga, Takayuki Shibasaki, Shinya Masaki, Reiko
Sakamoto, Nobuaki Yoshida(Institute of Medical Science, University of Tokyo)

P-12

FGF signaling inhibitor Sprouty4 modulates preference between neuronaland glial differentiation
Taichi Kashiwagi1, Tetsushi Kagawa1, Akihiko Yoshimura2, Tetsuya
Taga1(1Department of Stem Cell Regulation, Medical Research Institute Tokyo
Medical and Dental University, 2Department of Microbiology and Immunology,
Keio University School of Medicine)

P-13

Essential role of Nucleostemin in injury-induced liver regeneration
Haruhiko Shugo1,2, Takako Ooshio1, Shuichi Kaneko2, Atsushi Hirao1(1Division of Molecular Genetics, Cancer and Stem Cell Research Program,Cancer Research Institute, Kanazawa University, 2Department of
Gastroenterology,Kanazawa University Graduate School of Medicine)

P-14

Analysis of hepatic differentiation in conditional β-catenin knockout mice byusing NGFR promoter
Yoshiaki Matsumi, Keiko Shirakawa, Keita Kanki, Goshi Shiota(Division of Molecular and Genetic Medicine, Graduate School of Medicine,
Tottori University)

P-15

Analysis of glial cell sub-lineages in the mouse central nervous system
Tetsushi Kagawa1, Rieko Nomura1, Takeshi Shimizu2, Kimi Araki3,
Naoki Takeda4, Naomi Nakagata5, Ikuo Nobuhisa1, Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo
Medical and Dental University, Tokyo, Japan; 2Department of Biological
Sciences & Division of Bioengineering, Research Centre of Excellence in
Mechanobiology, National University of Singapore, 3Division of Developmental
Biology, 4Division of Transgenic Technology, and 5Division of Reproductive
Engineering, Center for Animal Resources and Development, Kumamoto
University)

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9th Stem Cell Research Symposium

May 13 (Fri)-14(Sat), 2011

P-16

The role of cyclin D1 in inhibition of astrocyte differentiation from neural
stem/progenitor cells
Norihisa Bizen1, Toshihiro Inoue2, Takeshi Shimizu3, Tetsushi
Kagawa1, Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo
Medical and Dental University, 2Department of Ophthalmology and Visual
Science, Graduate School of Medical Sciences, Kumamoto University,
3Department of Biological Science & Division of Bioengineering, National
University of Singapore)

P-17

Hypoxic culture condition facilitates the proliferation and differentiation
potentials of mouse dental pulp stem cells.
Ryusuke Nakatsuka, Yoshikazu Matsuoka, Masaya Takahashi, Ryuji
Iwaki, Yutaka Sasaki, Yoshiaki Sonoda(Department of Stem Cell Biology and Regenerative Medicine, Graduate
School of Medical Science, Kansai Medical University)

P-18

Enhanced competitive repopulation ability of hematopoietic stem cells by
inhibition of Spred-1
Yuko Tadokoro1, Atsushi Hirao1, Takayuki Hoshii1, Kazuhito Naka1,
Koji Eto2, Hideo Ema2, Satoshi Yamazaki2, Reiko Kato3, Akihiko
Yoshimura3,4, Hiromitsu Nakauchi2(1Division of Molecular Genetics, Cancer and Stem Cell Research Program,Cancer Research Institute, Kanazawa University, 2Division of Stem Cell
Therapy, Center for Stem Cell Biology and Regenerative Medicine, The
Institute of Medical Science, The University of Tokyo, 3Division of Molecular
and Cellular Immunology, Medical Institute of Bioregulation, Kyushu
University, 4Department of Microbiology and Immunology, Keio University
School of Medicine)

P-19

HOXA9 acts as an E3 ubiquitin ligase for Geminin to provide hematopoietic
cells with cellular proliferation potential.
Yoshinori Ohno, Yasunaga Shin’ichiro, Motoaki Ohtsubo, Hiroki
Tetsuguchi, Takuma Furutani, Ai Kawashima, Yoshie Nakashima,
Yoshihiro Takihara(Dept. Stem Cell Biol., RIRBM, Hiroshima Univ.)

P-20

Histone acetyltransferase MOZ and MORF are essential for hematopoiesis
and self renewal of hematopoietic stem cells
Takuo Katsumoto,
Kitabayashi

NozomiTakahashi,

Naomi

Yoshida,Issay(Hematological Malignancy Division, National Cancer Center ResearchInstitute)P-21

Bmi1 Confers Stress Resistance to Self-Renewing Hematopoietic Stem Cells
Shunsuke Nakamura, Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University)

P-22

MT1-MMP plays a critical role in the modulation of hematopoiesis.
Chiemi Nishida1, Beate Heissig2,
Nakauchi4, Koichi Hattori1

Motoharu

Seiki3,Hiromitsu(1Division of Stem Cell Regulation, 2Frontier Research Initiative, 3Division ofCancer Cell Research, 4Division of Stem Cell Therapy, The Institute of Medical
Science, The University of Tokyo)

9th Stem Cell Research Symposium

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May 13 (Fri)-14(Sat), 2011

P-23

Role of SoxF family proteins in the maintenance of immature phenotype ofhematopoietic progenitors in the aorta-gonad-mesonephros region
Ikuo Nobuhisa1,2, Yuko Kishikawa2, Uemura Mami3, Maha Anani1,
Gomaa Ahmed1,2, Masami Kanai-Azuma3, Yoshiaki Kanai4, Tetsuya
Taga1,2(1Dept. of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental Univ., 2Dept. of Cell Fate Modulation, IMEG, Kumamoto Univ.,
3Dept. of Experimental Animal Model for Human Disease, Center for
Experimental Animal, Tokyo Medical and Dental Univ., 4Dept. of Veterinary
Anatomy, Graduate School of Agricultural and Life Science, the Univ. of Tokyo)

P-24

FoxO1 is required for hemangioblast development in mice
Ken-ichi Minehata1, Kenji Kitajima1, Michael Kyba2, Takahiko Hara1(1Stem Cell Project, Tokyo Metropolitan Institute of Medical Science,
2Department of Pediatrics, University of Minnesota)

P-25

Hematopoietic Disturbance in Iron-Overload
Hiroshi Okabe, Takahiro Suzuki, Eisuke Uehara, Masuzu Ueda,
Tadashi Nagai and Keiya Ozawa(Division of Hematology, Department of Medicine, Jichi Medical University,
Japan)

P-26

Expression cloning of a reprogramming activity that induces bone marrowadherent myofibroblasts toward hematopoietic stem cells: Interleukin 1β
promotes the expression of CD34 and cytokine receptors
Haruko Tashiro, Ryosuke Shirasaki, Tadashi Yamamoto, Yoko Oka,
Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji(Department of Hematology/Oncology, Teikyo University School of Medicine)

P-27

Dynamics of the expression
stem/progenitor cells

of CXCR4

onmurinehematopoietic

Yutaka Sasaki, Yoshikazu Matsuoka, Masaya Takahashi, Ryuji Iwaki,
Ryusuke Nakatsuka, Yoshiaki Sonoda(Department of Stem Cell Biology and Regenerative Medicine, Graduate
School of Medical Science, Kansai Medical University)

P-28

Single Stem Cell Based Analysis of Signal Transduction Regulating
Vasculogenic Fate of Umbilical Cord Blood-CD133+ cell
Haruchika Masuda, Tomoko Shizuno, Atsuko Sato, Shotaro Obi,
Asahara Takayuki(Department of Regenerative Medicine, Tokai University. School of Medicine.)

P-29

Effects of sex hormones on proliferation of breast cancer stem cells
Yasunari Kanda, Naoya Hirata, Lin Waka, Yuko Sekino.
(Division of Pharmacology, National Institute of Health Sciences)

P-30

Salinomycin inhibits proliferation and migration of endometrial cancer
stem-like cells
Soshi Kusunoki, Kiyoko Kato, Nurisimangul Yusuf, Tetsunori Inagaki,
Satoru Takeda(Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo
University)

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9th Stem Cell Research Symposium

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P-31

Sodium butyrate inhibits the self-renewal capacity of endometrial tumor
side-population cells by inducing a DNA damage response
Kiyoko Kato1, Aya Kuhara2,Tomoko Yoneda2,Takafumi Inoue2,Tomoka
Takao2, Tatsuhiro Ohgami2, Li Dan2, Ayumi Kuboyama2, Soshi
Kusunoki1, Satoru Takeda1, Norio Wake2(1Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo
University, 2Department of Obstetrics and Gynecology, School of Medicine)P-32

Evaluation of 5-hydroxymethylcytosine in blood cells from normal subjects
and patients with hematologic malignancies
Mamiko Sakata-Yanagimoto1, Terukazu Enami1, Hideharu Muto1,
Seishi Ogawa2, Shigeru Chiba1(1Department of Hematology, Graduate School of Comprehensive Human
Sciences, University of Tokyo, 2Cancer Genomics Project, University of Tokyo)

P-33

Myofibroblasts originating from myelogenous leukemia cases form blastoma
in severe combined immunodeficiency mice
Ryosuke Shirasaki, Haruko Tashiro, Tadashi Yamamoto, Yoko Oka,
Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji(Department of Hematology/Oncology, Teikyo University School of Medicine)

P-34

Immuno-editing of leukemic stem cells in MLL/ENL mouse leukemia model
Jun Nakata1, Naoki Hosen2, Atsushi Okumura2, Yusuke Shimizu2,
Minghua Guo2, Yuka Fujioka2, Hiroko Kinoshita2, Haruo Sugiyama2(1Department of Respiratory Medicine, Rheumatology, and Allergy,
2Department of Functional Diagnostic Science, Osaka University Graduate
School of Medicine)

9th Stem Cell Research Symposium

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