Stock Handling Regulations
Revised: August 5, 2022

Eisai Co., LtdStock Handling Regulations

Chapter 1 General(Purpose)
Article 1 In accordance with the stipulations of Article 12 of the Articles ofIncorporation of the Company, handling and fees related to stock and newshare subscription rights, as well as procedures, etc., for the exercise of rights
by shareholders, shall conform to the stipulations of these Regulations, aswell as any relevant stipulations made by Japan Securities Depository Center,Inc. (hereinafter, "JASDEC"), which is the depository institution, and thesecurities companies, trust banks, etc. (hereinafter, "securities companies,etc.") that act as the account management institution.
2Handling and fees related to special accounts opened in accordance withagreements concluded between the Company and a trust bank specified by
the Company, as well as procedures, etc., for the exercise of rights byshareholders, shall conform to the stipulations of these Regulations, as wellas any relevant stipulations made by the applicable trust bank.

(Shareholder Registry Administrator)
Article 2 The shareholder registry administrator for the Company and the location atwhich related office work will be conducted shall be as follows.
Shareholder registry administrator
1-4-5, Marunouchi, Chiyoda-ku, Tokyo
Mitsubishi UFJ Trust and Banking Corporation
Office work location
1-4-5, Marunouchi, Chiyoda-ku, Tokyo
Mitsubishi UFJ Trust and Banking Corporation
Stock Transfer Agency Department

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(Requests and Notifications)
Article 3 Requests and notifications in accordance with these Regulations shall bemade using the form stipulated by the Company. However, cases in which therequest or notification is made via the securities companies, etc., andJASDEC, and cases stipulated in Article 18, Paragraph 1, may be excluded
from this requirement.
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When the request or notification indicated in the preceding Paragraph is madevia an agent, written verification of the agent's authority must be submitted,and when the request or notification requires the agreement of a supervisor orassistant, written verification of such agreement must be submitted.

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When the request or notification indicated in Paragraph 1 is made via
securities companies, etc., and JASDEC, or via securities companies, etc., theCompany shall be able to handle the request or notification as if it had been
made by the shareholder himself/herself.

4The Company shall be able to demand that the party making the request or
notification indicated in Paragraph 1 submit materials verifying that said
party is the shareholder or agent himself/herself.

5

When the Company has demanded submission of the materials stipulated in
the preceding Paragraph, the Company shall not accept the request or
notification indicated in Paragraph 1 unless the materials have beensubmitted.

6

When it is necessary for the Company to confirm that parties claiming to beshareholders are true shareholders, when it has acknowledged the intention ofa specific party to make a request, etc., as a shareholder, or in the case ofother justifiable reasons, the Company shall be able to make the requests
stipulated in Article 277 of the Act on Transfer of Bonds, Stocks, etc.
(hereinafter, "Bond Transfer Act") to JASDEC or the securities companies,etc.

2Chapter 2 Listing or Recording, etc., in the Shareholder Registry(Listing or Recording in the Shareholder Registry)
Article 4 The Company shall list or record in the shareholder registry in accordancewith the general shareholders notification received from JASDEC.
2When the Company has received notification of changes to the addresses ofparties that have been listed or recorded in the shareholder registry byJASDEC (including standing agents and registered pledgees; hereinafter,"shareholders, etc.") or notification of changes to other items listed in theshareholder registry, the Company shall change the listing or record in theshareholder registry in accordance with such notification.

3In addition to the preceding 2 Paragraphs, the Company shall list or record
items in the shareholder registry for the issuance of new shares and asotherwise stipulated in laws and regulations.

4When it is necessary for notification of shareholders by the Company, and theBoard of Directors has judged that it is necessary to reflect current owners ofstock in the shareholder registry, or in the case of other justifiable reasons,the Company shall be able to make the requests stipulated in Article 151,
Paragraph 8 of the Bond Transfer Act to JASDEC.

(Characters, etc., Used in the Shareholder Registry)
Article 5 The characters and symbols specified by JASDEC shall be used to list orrecord items in the shareholder registry of the Company.
(Listing or Recording, etc., in the Original New Share Subscription RightsRegistry)
Article 6 Requests for the listing or recording of items in the original new sharesubscription rights registry, the registration, transfer, or cancellation of theright of pledge for new share subscription rights, and the display orcancellation of trust assets shall be made to the shareholder registryadministrator.

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It shall be possible to stipulate separately the handling of new sharesubscription rights, in addition to the stipulations of the preceding Paragraph.

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The characters and symbols specified by JASDEC may be used for the listingor recording of items in the original new share subscription rights registrywhen changing the system for management of the original new sharesubscription rights registry or in other cases in which it is necessary.

Chapter 3 Notifications(Notification of the Address and Name of Shareholders, etc.)
Article 7 Shareholders, etc., must notify the Company of their address and name.
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Notification of or changes to items indicated in the preceding Paragraph mustbe submitted via the securities companies, etc., and JASDEC. However, thecases stipulated in Article 4, Paragraph 3 may be excluded from thisrequirement.

(Notification by Shareholders, etc., Residing Overseas)
Article 8 Shareholders, etc., who reside overseas must select a standing agent in Japan,or establish a location for receiving notifications in Japan, and notify theCompany of such.
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Notification of or changes to items indicated in Paragraph 1 must besubmitted via the securities companies, etc., and JASDEC. However, thecases stipulated in Article 4, Paragraph 3 may be excluded from thisrequirement.

(Representatives of Corporations)
Article 9 When shareholders, etc., are companies, the shareholder must submit thename and position of its representative.
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Notification of or changes to items indicated in the preceding Paragraph mustbe submitted via the securities companies, etc., and JASDEC. However, the4cases stipulated in Article 4, Paragraph 3 may be excluded from thisrequirement.
(Representatives of Joint Shareholders)
Article 10 Shareholders that own stock jointly must establish a representative andsubmit the address, name, and title of the representative.
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Notification of or changes to items indicated in the preceding Paragraphmust be submitted via the securities companies, etc., and JASDEC.
However, the cases stipulated in Article 4, Paragraph 3 may be excluded
from this requirement.

(Statutory Agent)
Article 11 When there is a statutory agent, such as individuals with parental authority
or guardians, for shareholders, etc., the address, name, and title of thestatutory agent must be submitted.
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Notification of, changes to, or cancellation of items indicated in thepreceding Paragraph must be notified via the securities companies, etc., andJASDEC. However, the cases stipulated in Article 4, Paragraph 3 may beexcluded from this requirement.

(Other Notifications)
Article 12 In addition to the notifications stipulated from Article 7 through thepreceding Article, when submitting notification to the Company, thenotification must be submitted via securities companies, etc., and JASDEC,
or via securities companies, etc., unless otherwise specified by the Company.
However, the cases stipulated in Article 4, Paragraph 3 may be excluded
from this requirement.
2Notifications that cannot be received or relayed by the securities companies,
etc., shall be submitted to the shareholder registry administrator.

(Notification Items, etc., for Holders of New Share Subscription Rights)
Article 13 Article 7 through the preceding Article shall apply for notification items andthe notification method for parties listed or recorded in the Company's
original new share subscription rights registry. However, if no separate

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stipulation is made in accordance with Article 6, Paragraph 2, notification
shall be made to the shareholder registry administrator.

Chapter 4 Purchase of Fractional Shares(Purchase Request Method)
Article 14 When requesting the purchase of a fractional share, the purchase shall bemade via securities companies, etc., and JASDEC, in accordance with theJASDEC stipulations.
(Determination of Purchase Price)
Article 15 The unit purchase price of fractional shares shall be the closing price at amarket opened on the Tokyo Stock Exchange, on the day on which therequest indicated in the preceding Article arrives at the location handlingoffice work for the shareholder registry administrator stipulated in Article 2.
However, if no trading is completed on that day, the price shall be the first
subsequent trading price.
2The purchase price shall be the unit purchase price indicated in thepreceding Paragraph multiplied by the number of shares requested for thepurchase.

(Payment of the Purchase Price)
Article 16 Except in cases stipulated separately by the Company, the Company shall
pay the purchase price to the party requesting purchase on the fourthbusiness day from the day after the date on which the purchase price isdetermined.
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In the case indicated in the preceding Paragraph, if the purchase price is asurplus dividend, share split-up, or other price with rights, the price shall bepaid by the record date.

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(Transfer of Purchased Stock)
Article 17 Fractional shares for which a purchase request has been made shall betransferred to the Company's transfer account on the date on which payment
procedures have been completed for the purchase price stipulated in thepreceding Article.

Chapter 5 Additional Purchase of Fractional Shares(Method of Requesting Additional Purchase)
Article 18 When requesting the additional purchase of a fractional share, the purchaseshall be made via securities companies, etc., and JASDEC, in accordancewith the JASDEC stipulations.
(Limitations on Requests for Additional Purchase)
Article 19 If the total number of shares for which a request for additional purchase wasmade on the same day exceeds the number of shares of treasury stock thatare held for requests for additional purchase, the request shall not be valid.
(Determination of Price for Additional Purchase)
Article 20 The unit price for additional purchase of fractional shares shall be theclosing price at a market opened on the Tokyo Stock Exchange, on the dayon which the request indicated in Article 18 arrives at the location handlingoffice work for the shareholder registry administrator stipulated in Article 2.
However, if no trading is completed on that day, the price shall be the first
subsequent trading price.
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The price for additional purchase shall be the unit price for additionalpurchase indicated in the preceding Paragraph multiplied by the number ofshares requested for the additional purchase.

(Suspension of Acceptance of Requests for Additional Purchase)
Article 21 The Company shall suspend acceptance of requests for additional purchase7

for the period starting on the day 10 business days prior to the date indicatedin the following Items and ending on the applicable day indicated in thefollowing Items.
(1) March 31(2) September 30(3) Other shareholder record date2In addition to the stipulations of the preceding Paragraph, acceptance ofrequests for additional purchase may be suspended if judged to be necessary
by the Company or JASDEC.

(Timing of Transfer of Additionally Purchased Shares)
Article 22 The Company shall request the transfer of fractional shared that have beenrequested for additional purchase to the account of the individual making
the request, on the day on which it is confirmed that payment for theadditional purchase has been deposited into the bank account specified bythe Company.

Chapter 6

Method of Exercising Shareholder Rights, etc.

(Requests for Documents and Filing of Objections)
Article 23 Requests for printed copies of documents that include the General
Shareholders' Meeting Reference Materials stipulated in Article 325-5,Paragraph 1 of the Companies Act (hereinafter, "requests for printedcopies") and other contents that are provided electronically and objections
that are filed as stipulated in Paragraph 5 of the same Article shall be
submitted in writing. However, when requests for printed copies are madethrough a securities company, etc., or JASDEC, the stipulations of thesecurities company, etc., or JASDEC shall apply8(Method of Exercising Minority Shareholder Rights, etc.)
Article 24 When exercising the minority shareholder rights, etc., stipulated in Article
147, Paragraph 4 of the Bond Transfer Act directly toward the Company, awritten receipt, signed with seal affixed, shall be attached for individual
shareholder notification (the notification stipulated in Article 154, Paragraph
3 of the Bond Transfer Act) delivered by securities companies, etc. However,a signature can be used instead of a seal in the case of foreign individuals.
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Article 3, Paragraphs 2, 4, and 5 shall apply to the exercise of the minority
shareholder rights, etc., indicated in the preceding Paragraph, and othershareholder rights.

(General Shareholders' Meeting Reference Materials for Shareholder Proposals)
Article 25 When shareholders' proposal rights have been exercised in accordance withthe stipulations of Paragraph 1 of the preceding Article, the following items,
or an outline of such if the number of characters exceeds 400 (or a number
deemed necessary and established separately by the Company), shall be
included in the General Shareholders' Meeting reference materials.
(1) Reason for the proposal(2) Overview of the item

Chapter 7 Fees(Fees)
Article 26 No fees shall be charged for the handling of Company stock.
2Fees paid by shareholders, etc., to securities companies, etc., or JASDEC
shall be the responsibility of the shareholders, etc.

9Supplementary Provisions(Revision of the Article Number in Article 1 Accompanying Revision of theArticles of Incorporation)
Article 1 If, in accordance with a decision of the General Shareholders' Meeting, thearticle number of Article 12 (Stock Handling Regulations) of the Company's
Articles of Incorporation is changed, "Article 12 of the Articles ofIncorporation" as found in Article 1 shall be deemed to have been altered inaccordance with the new article number.
(End of document)

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