12th Stem Cell Research Symposium
The First Day : Friday, May 30
Oral Presentation
9:00

Poster
D iscussion

The Second Day : Saturday, May 31
Oral Presentation

Opening Remarks

9:00~9:10

Poster
Discussion
9:00

9:00~9:45

Session 5

9:10~10:25

Stem Cell and Cancer Metabolites
Chair : Issay Kitabayashi

Session 1

Hematopoietic Stem Cells (1)9:45~10:45

Chair : Atsushi Iwama

10:00

10:00

Session 6

Leukemia Stem Cells (1)Chair : Mineo Kurokawa

10:25~11:25

Session 2
11:00

10:45~11:00

Hematopoietic Stem Cells (2)Coffee Break
11:00

11:00~12:00

Chair : Yoshiaki Sonoda

Session 7
11:25~11:40

Chair : Hiromi Iwasaki

11:40~12:25

12:00

Leukemia Stem Cells (2)Coffee BreakSession 3

Niches for
Hematopoietic Stem Cells

12:00

12:00~12:45

Korea-Japan Bilateral Session

Chair : Fumio Arai

Chair : Shigeru Chiba

12:25~13:45
12:45~13:30

13:00

Lunch Time

PosterSessionLunch Time

PosterSession

13:00

13:30~14:15

Session 8
13:45~14:45

14:00

Cancer Stem Cells (1)Chair : Tetsuya Taga

Session 4

iPS / ES Cells

14:00

14:15~15:00

Chair : Kinichi Nakashima

Session 9

Cancer Stem Cells (2)Chair : Noriko Gotoh

14:45~15:45

15:00

Special Session on
iPS / ES Cells

15:00~15:15

15:00

Coffee Break

15:15~16:00

Session 10

Chair : Takafumi Kimura

Tissue Stem Cells (1)15:45~16:00

16:00

Chair : Atsushi Suzuki

Coffee Break

16:00~16:35

Keynote Lecture (1)Session 11

Tissue Stem Cells (2)Kristen Kroll
Chair : Shin’ ichiro Yasunaga

Chair : Daisuke Sugiyama

16:35~17:10

Keynote Lecture (2)16:45~17:00

R. Keith Humphries

17:00

16:00

16:00~16:45

Closing Remarks
17:00

Chair : Koichi Akashi
17:10~17:45

Keynote Lecture (3)Michele Pagano
Chair : Toshio Suda
17:45~17:55

18:00

General Meeting

17:55~

18:00

Reception(Venue for Poster Presentation)

19:00

19:00

1

The 12th Stem Cell Research Symposium Program

The 12th Stem Cell Research Symposium
Friday, May 30.

The First Day

Registration・Exhibit posters
Opening Remarks

Program

Organizer

8：30～
Yoshihiro Takihara

9：00～9：10(Department of Stem Cell Biology, Research Insitute for Radiation Biology andMedicine, Hiroshima University)

Session 1 : Hematopoietic Stem Cells (1)Chair

9：10～10：25

Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University)

O-1

WDR68 is critical for maintenance of long-term hematopoietic stem cells
Miu Adachi(Division of Hematological Malignancy, National Cancer Center
Research Institute)

O-2

Pot1 regulates hematopoietic stem cell activity during aging
Kentaro Hosokawa1, Yoshiko Ikushima2, Benjamin MacArthur3,
Toshio Suda2, Fumio Arai1(1Department of Stem Cell Biology and Medicine, Graduate School of
Medical Sciences, Kyushu University, 2Department of Cell
Differentiation,School of Medicine, Keio University, 3Faculty of
Medicine & School of Mathematics, University of Southampton)

O-3

Clock gene Bmal1 is dispensable for intrinsic properties of murine HSCs
Aki Ieyasu, Satoshi Yamazaki, Hiromitsu Nakauchi(Laboratory of Stem Cell Therapy, Center for Experimental Medicine,the Institute of Medical Science, the University of Tokyo)

O-4

The role of Prdm16 in hematopoietic stem cell function
Kenjiro Kamezaki1, Koichi Akashi1, Hans Snoeck2(1Department of Medicine and Biosystemic Science, Kyushu
University Graduate School of Medical Sciences, 2Columbia Center forTranslational Immunology, Columbia University Medical Center)

O-5

Identification and functional analysis of self-renewing hematopoietic stem cells byusing Geminin-EYFP knock-in mice
Shin’ichiro Yasunaga1, Yoshinori Ohno1, Kyoko Suzuki-Takedachi1,
Toshiki Kurogi1, Mimoko Santo1, Motoaki Ohtsubo1,2,
Yoshihiro Takihara1(1Department of Stem Cell Biology, Research Institute for Radiation
Biology and Medicine, Hiroshima University, 2Department of Food
andFermentation Science, Beppu University)

2The 12th Stem Cell Research Symposium Program

Session 2 : Hematopoietic Stem Cells (2)Chair

10：25～11：25

Yoshiaki Sonoda(Department of Stem Cell Biology and Regenerative Medicine, Graduate Schoolof Medical Science, Kansai Medical University)

O-6

Cord blood-derived CD34-negative hematopoietic stem cells (HSCs) are
myeloidbiased HSCs residing at the apex of the human HSC hierarchy
Yoshikazu Matsuoka1, Keisuke Sumide1, Masaya Takahashi2,
Ryusuke Nakatsuka1, Tatsuya Fujioka1, Yutaka Sasaki1,
Yoshiaki Sonoda1(1Department of Stem Cell Biology and Regenerative Medicine,
Graduate School of Medical Science, Kansai Medical University,
2Department of Pediatrics, Kansai Medical University)

O-7

CD133 is a positive marker of human cord blood-derived CD34-negative
hematopoietic stem cells
Masaya Takahashi1, Yoshikazu Matsuoka2, Keisuke Sumide2,
Ryusuke Nakatsuka2, Tatsuya Fujioka2, Yutaka Sasaki2,
Kazunari Kaneko1, Yoshiaki Sonoda2(1Department of Pediatrics, Kansai Medical University, 2Departmentof Stem Cell Biology and Regenerative Medicine, Kansai Medical
University)

O-8

Embryonic hematopoietic progenitors migrate through muscle before homing tobone marrow
Yuka Tanaka1,2, Tomoko Inoue3, Kasem Kulkeaw3, Yanagi Chiyo1,
Senji Shirasawa2, Yoichi Nakanishi1, Daisuke Sugiyama3(1Center for Clinical and Translational Research, Kyushu University
Hospital, 2Department of Cell Biology, Faculty of Medicine, Fukuoka
University, 3Department of Research and Development of Next
Generation Medicine, Kyushu University Faculty of Medical Sciences)

O-9

Inhibitory effect of Spred1 on self-renewal activity mediated by cell-cell interaction
determines size of hematopoietic stem cell pool
Yuko Tadokoro1, Takayuki Hoshii1, Kazuhito Naka2, Koji Eto3,
Hideo Ema4,Satoshi Yamazaki5, Akihiko Yoshimura6,
Hiromitsu Akauchi5, Atsushi Hirao1(1Division of Molecular Genetics, Cancer Research Institute,
KanazawaUniversity, 2Exploratory Project on Cancer Stem Cells,
Cancer ResearchInstitute, Kanazawa University, 3Department ofClinical Application,Center for iPS Cell Research and Application(CiRA), Kyoto University,4Department of Cell Differentiation, Schoolof Medicine, Keio University,5Division of Stem Cell Therapy, Center
for Stem Cell Biology andRegenerative Medicine, The Institute ofMedical Science, The Universityof Tokyo, 6Department ofMicrobiology and Immunology, Keio University School of Medicine)

Coffee Break

11：25～11：40

3

The 12th Stem Cell Research Symposium Program

Session 3 : Niches for Hematopoietic Stem Cells
Chair

11：40～12：25

Fumio Arai
(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)

O-10 NG2+ arteriolar pericytes form niches for dormant hematopoietic stem cells
Yuya Kunisaki1,2, Dachuan Zhang2, Toshihide Mizoguchi2,
Aviv Bergman3, Paul Frenette2(1Kyushu University Department of Medicine and Biosystemic
Science, 2Ruth L. and David S. Gottesman Institute for Stem Cell andRegenerative Medicine Research Albert Einstein College of Medicine,
3Department of Systems and Computational Biology, Albert Einstein
College of Medicine)O-11 Role of Oncostatin M in the bone marrow microenvironment for hematopoiesis
Fumi Sato1, Minoru Tanaka2, Atsushi Miyajima1(1Laboratory of Cell Growth and Differentiation, Institute of
Molecular and Cellular Biosciences, The University of Tokyo,
2Laboratory of Stem Cell Regulation, Institute of Molecular andCellular Biosciences, The University of Tokyo)
O-12 The niche factor Angiopoietin-1 regulates stem and progenitor cell numbers bycontrolling hematopoietic stem cell division asymmetry
Yoshiko Ikushima1, Ben D. MacArthur2, Patrick S. Stumpf2,
Kentaro Hosokawa1,3, Toshio Suda1, Fumio Arai1,3(1Department of Cell Differentiation, School of Medicine, Keio
University, 2Centre for Human Development, Stem Cells andRegeneration, Institute of Developmental Sciences, School ofMathematics, and Institute for Life Sciences, University ofSouthampton, 3Department of Stem Cell Biology and Medicine,
Graduate School of Medical Sciences, Kyushu University)

Lunch Time /Poster Session

12：25～13：45

Session 4 : iPS/ES Cells

13：45～14：45

Chair

Kinichi Nakashima(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Science, Kyushu University)

O-13 Lactic acid bacteria-derived materials convert human fibroblasts to multipotential
cells
Kunimasa Ohta, Rie Kawano, Naofumi Ito(Kumamoto University)
O-14 Search of machinery for efficient reversion from EpiSC to ESC-like cell
Hideyuki Murayama(The Institute of Medical Science, University of Tokyo)
O-15 Generation of a mouse model capable of visualizing pluripotent cells in
Nanogexpressing cells
Maiko Terada1, Sayaka Sekiya1, Atsushi Suzuki1,2(1Division of Organogenesis and Regeneration, Medical Institute of
Bioregulation, Kyushu University, 2Core Research for Evolutional
Science and Technology (CREST))

4The 12th Stem Cell Research Symposium Program
O-16 iPS cells show hypersensitivity to X-irradiation than isogenic somatic cells, leading
to p53-dependent apoptosis
Harunobu Kagawa1, Hidehiko Kawai2, Tetsushi Sakuma3,
Takashi Yamamoto3, Bunshyou Shiotani1, Akira Shimamoto1,
Hidetoshi Tahara1(1Department of Cellular and Molecular Biology, Graduate School of
Biomedical Science, and Health, Hiroshima University, 2Departmentof Regulatory Radiobiology, Research Institute for Radiation Biology
and Medicine, Hiroshima University, 3Department of Mathematicaland Life Sciences, Graduate School of Science, Hiroshima University)

Special Session on iPS/ES Cells
Chair

14：45～15：45

Takafumi Kimura(Department of Fundamental Cell Technology, Center for iPS Cell Research andApplication (CiRA), Kyoto University)

O-17 Strategies for manufacturing and banking of clinical-grade human embryonic stem
cell lines
Tsuneo Takahashi(The Institute for Frontier Medical Sciences, Kyoto University)
O-18 Autologous transplantation of iPS cell-derived neurons to the brain of non-humanprimateAsuka Morizane1, Daisuke Doi1, Tetsuhiro Kikuchi1,
Jun Takahashi1,2,3(1Department of Clinical Application, Center for iPS Cell Researchand Application, Kyoto University, 2Department of Biological Repair,
Institute for Frontier Medical Sciences, Kyoto University,
3Department of Neurosurgery, Kyoto University Graduate School of
Medicine)
O-19 Regeneration of immune cells for immunotherapy
Shin Kaneko(Shin Kaneko Laboratory, CiRA, Kyoto University)

Coffee Break

15：45～16：00

Keynote Lecture (1)16：00～16：35

Chair

K-1

Shin'ichiro Yasunaga(Department of Stem Cell Biology, Research Institute for Radiation Biology andMedicine, Hiroshima University)

Epigenetic regulation of embryonic cell fate selection
Kristen L. Kroll, Ph.D., Elizabeth Caronna,

Dhananjay Yellajoshyula, Ethan S. Patterson, Matthew Elitt,
Pamela M. Hummert(Department of Developmental Biology, Washington University Schoolof Medicine, Saint Louis)

5The 12th Stem Cell Research Symposium Program

Keynote Lecture (2)Chair

16：35～17：10

Koichi Akashi(Department of Medicine and Biosystemic Science, Faculty of Medicine, Kyushu
University)

K-2

Targeting self-renewal function of normal and leukemic
hematopoietic stem cells
R. Keith Humphries, M.D., Ph.D.
(Terry Fox Lab, BC Cancer Agency, Vancouver)

Keynote Lecture (3)
Chair
K-3

17：10～17：45

Toshio Suda

(Department of Cell Differentiation Keio University, School of Medicine)SCF ubiquitin ligase complexes regulate modular elements ofmolecular machines
Michele Pagano, M.D., Ph.D.
(Howard Hughes Medical Institute and Department of Pathology,
NYU Cancer Institute, New York University School of Medicine, NewYork)

General Meeting
Chief Director

Koichi Akashi

17：45～17：55(Department of Medicine and Biosystemic Science, Faculty of Medicine,
Kyushu University)

Reception(Venue for Poster Presentation)

6

17：55～

The 12th Stem Cell Research Symposium Program

Saturday, May 31.

The Second Day

Session 5 : Stem Cell and Cancer Metabolites
Chair

9：00～9：45

Issay Kitabayashi(Division of Hematological Malignancy National Cancer Center ResearchInstitute)

O-20 Critical roles of the IDH2 mutation in development and maintenance of acute
myeloid leukemia
Yoko Ogawara1, Takuo Katsumoto1, Yukiko Aikawa1, Yutaka Shima1,
Yuki Kagiyama1, Tomoyoshi Soga2, Hironoroi Matsunaga3,
Takahiko Seki3, Kazushi Araki3, Issay Kitabayashi1(1National Cancer Center Research Institute, 2Institute for Advanced
Biosciences, Keio University, 3R&D Division, Daiichi Sankyo Co., ltd)
O-21 MicroRNA-369 dictates glucose metabolism and cell differentiation of pluripotent
stem cells by splicing PKM2
Masamitsu Konno1, Nobuhiro Tanuma2, Hiroshi Shima2,
Noriko Gotoh3, Yuichiro Doki4, Masaki Mori4, Hideshi Ishii1(1Department of Frontier Science for Cancer and Chemotherapy,
Osaka University Graduate School of Medicine, 2Division of Cancer
Chemotherapy, Miyagi Cancer Center Research Institute, 3Division ofCancer Cell Biology, Cancer Research Institute of Kanazawa
University, 4Department of Gastrointestinal Surgery, Osaka
University Graduate School of Medicine)
O-22 Methionine metabolism regulates maintenance and differentiation of humanpluripotent stem cells
Nobuaki Shiraki1, Yasuko Shiraki2, Tomonori Tsuyama1,3,
Fumiaki Obata4,5, Masayuki Miura4,5, Genta Nagae6,
Hiroyuki Aburatani6, Kazuhiko Kume1,7, Fumio Endo2, Shoen Kume1,3(1Department of Stem Cell Biology, Institute of Molecular Embryology
and Genetics, Kumamoto University, 2Department of Pediatrics,
Graduate School of Medical Sciences, Kumamoto University,
3Program for Leading Graduate Schools “HIGO”, Kumamoto
University, 4Department of Genetics, Graduate School of
Pharmaceutical Sciences, The University of Tokyo, 5CREST, Japan
Science and Technology Agency, 6Genome Science Division, ResearchCenter for Advanced Science and Technology, The University of Tokyo,
7Department of Neuropharmacology, Graduate School of
Pharmaceutical Sciences, Nagoya City University)

Session 6 : Leukemia Stem Cells (1)Chair

9：45～10：45

Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine,
The University of Tokyo)

O-23 Treatment with Hedgehog inhibitor, PF-913, attenuates leukemia-initiation
potential in AML cells
Yosuke Minami1, Nobuaki Fukushima2, Tomoki Naoe3(1Kobe University Hospital, 2Nagoya University School of Medicine,
3National Hospital Organization Nagoya Medical Center)

7

The 12th Stem Cell Research Symposium Program
O-24 BAALC promotes leukemogenesis by balancing MEK/ERK-dependent proliferation
with KLF4-derived differentiation block
Ken Morita1, Yosuke Masamoto1, Yuki Kagoya1, Keisuke Kataoka1,
Junji Koya1, Hideki Yashiroda2, Tomohiko Sato1, Shigeo Murata2,
Mineo Kurokawa1(1Department of Hematology & Oncology, Graduate School of
Medicine, the University of Tokyo, 2Laboratory of Protein Metabolism,
Graduate School of Pharmaceutical Sciences, the University of Tokyo)
O-25 Physiologic hypoxia promotes maintenance of CML stem cells despite effective
BCRABL1 inhibition
King Pan Ng1,8, Aditi Manjeri1, Kian Leong Lee2, Weijie Huang1,
Soo Yong Tan3, Charles T H Chuah1,4, Lorenz Poellinger2,6,
S Tiong Ong1,4,5,7(1Cancer and Stem Cell Biology Signature Research Program, Duke−
NUS Graduate Medical School, Singapore, 2Cancer Science Instituteof Singapore, National University of Singapore, 3Department of
Pathology, Singapore General Hospital, 4Department of Haematology,
Singapore General Hospital, 5Department of Medical Oncology,
National Cancer Centre, Singapore, 6Department of Cell andMolecular Biology, Karolinska Institutet, Sweden, 7Department ofMedicine, Duke University Medical Center, Durham, NC., 8Present
address: Cancer Science Institute of Singapore, National University ofSingapore)
O-26 Disruption of quiescence by p57 ablation confers oncogene addiction on leukemia
stem cells through altered microenvironmental regulation
Shoichiro Takeishi, Akinobu Matsumoto, Keiichi I. Nakayama(Department of Molecular and Cellular Biology, Medical Institute of
Bioregulation, Kyushu University)

Coffee Break

10：45～11：00

Session 7 : Leukemia Stem Cells (2)11：00～12：00

Chair

Hiromi Iwasaki(Center for Cellular and Molecular Medicine, Kyushu University Hospital)

O-27 Leukemia-associated mutations of DNMT3A inhibit differentiation ofhematopoietic stem and leukemic cells via aberrant recruitment of Bmi1
Junji Koya, Keisuke Kataoka, Takako Kishino-Tsuruta,
Tomohiko Sato, Mineo Kurokawa(Department of Hematology & Oncology, Graduate School of Medicine,
The University of Tokyo)
O-28 Dominant negative EZH2 promotes myeloid tumorigenesis in mouse BMT model
Kimihito C Kawabata, Daichi Inoue, Jiro Kitaura, Toshio Kitamura(Institute of Medical Science, the University of Tokyo)
O-29 Loss of p53 induces leukemic transformation in a murine model of JAK2
V617Finduced polycythemia vera
Takako Tsuruta-Kishino, Keisuke Kataoka, Junji Koya,
Hiroshi Kobayashi, Kensuke Narukawa, Tomohiko Sato,
Mineo Kurokawa(Department of Hematology & Oncology, Graduate School of Medicine,
The University of Tokyo)

8

The 12th Stem Cell Research Symposium Program
O-30 TIM-3, a leukemia stem cell marker, plays a role in leukemic transformation
through autocrine stimulatory signaling by its ligand, galectin-9
Yoshikane Kikushige, Junichiro Yuda, Takahiro Shima,
Toshihiro Miyamoto, Koichi Akashi(Department of Medicine and Biosystemic Sciences, Kyushu
University Graduate School of Medicine)

Korea-Japan Bilateral Session
Chair

12：00～12：45

Shigeru Chiba(Department of Hematology, Faculty of Medicine, University of Tsukuba)

KJ-1 Functional regulation of stem cells and embryos bycell-penetrating peptide (CPP)-conjugated recombinant proteinsDong Ryul Lee, Soomin Hong, Ning Jie Yang, Junghyun Jo(Department of Biomedical Science, CHA University, Seoul, Korea)

KJ-2

Molecular integration of hoxB4 and STAT3 for self-renewal ofhematopoietic stem cells: a model of molecular convergence forstemness
Il-Hoan Oh, MD, Ph.D

(Department of Medical Lifescience, Catholic University of Korea,
Seoul)

KJ-3

Studies for applying human ES/iPS cell cultures to therapeutic
development of Parkinson’s disease
Sang-Hun Lee, M.D., Ph.D.

(Department of Biochemistry and Molecular Biology, College ofMedicine,Hanyang University, Seoul)

Lunch Time /Poster Session

12：45～13：30

Session 8 : Cancer Stem Cells (1)13：30～14：15

Chair

Tetsuya Taga

(Department of Stem Cell Regulation, Medical Research Institute, Tokyo
Medical and Dental University (TMDU))

O-31 Discrimination of mutations arising in pre-malignant cells and those in lymphoma
cells in angioimmunoblasitc t-cell lymphoma
Mamiko Sakata-Yanagimoto, Shigeru Chiba(Department of Hematology, University of Tsukuba)
O-32 All-trans retinoic acid enhances cytotoxic effect of T cells with an anti-CD38
chimeric antigen receptor in acute myeloid leukemia
Keichiro Mihara1, Tetsumi Yoshida1, Tatsuji Mino1,
Yoshihiro Takihara2, Tatsuo Ichinohe1(1Department of Hematology/Oncology, Research Institute for
Radiation Biology and Medicine, Hiroshima University, 2Departmentof Stem Cell Biology, Research Institute for Radiation Biology andMedicine, Hiroshima University)

9The 12th Stem Cell Research Symposium Program
O-33 Hypoxia-induced noncoding ultraconserved transcripts in cancer
Naohiro Nishida1, Jana Ferdin2, Mircea Ivan3, George Calin4,
Masaki Mori5, Hideshi Ishii1(1Department of Frontier Science for Cancer and Chemotherapy,
Osaka University Graduate School of Medicine, 2Department of
Animal Science, Biotechnical Faculty, University of Ljubljana,
3Department of Medicine, Indiana University School of Medicine,
4Department of Experimental Therapeutics, MD Anderson Cancer
Center, 5Department of Gastroenterological Surgery, Osaka
University Graduate School of Medicine)

Session 9 : Cancer Stem Cells (2)Chair

14：15～15：00

Noriko Gotoh(Division of Cancer Cell Biology Cancer Research Institute, Kanazawa
University)

O-34 Activation of the canonical Wnt signaling pathway and enhancement of thetumorigenicity of breast cancer stem cells by microRNA-142
Yohei Shimono1, Taichi Isobe2, Shigeo Hisamori3, Michael Clarke4(1Kobe University, Graduate School of Medicine, 2Institute for Stem
Cell Biology and Regenerative Medicine, Stanford University, 3Kyoto
University, Graduate School of Medicine, 4Institute for Stem Cell
Biology and Regenerative Medicine, Stanford University)
O-35 Plasticity of CD44+ colorectal cancer stem cells depends on TGF-beta-induced
epithelial mesenchymal transition (EMT): evidences from an ex vivo culture
systemMichitaka Nakano1, Hiroshi Ariyama1, Yuta Okumura1,
Shingo Tamura1, Kohta Miyawaki1, Taichi Isobe1, Hitoshi Kusaba1,
Takashi Ueki2, Eishi Baba1, Koichi Akashi1(1Department of Medicine and Biosystemic Science, Kyushu
University Graduate School of Medical Sciences, 2Departement ofSurgery and Oncology, Kyushu University Graduate School of Medical
Science)O-36 Understanding of C6 glioma cancer stem cell niche with the use of synthetic
polymers
Tetsuya Taga, Kouichi Tabu
(Department of Stem Cell Regulation, Medical Research Institute,Tokyo Medical and Dental University (TMDU))

Coffee Break

15：00～15：15

Session 10 : Tissue Stem Cells (1)15：15～16：00

Chair

Atsushi Suzuki(Division of Organogenesis and Regeneration, Medical Institute of
Bioregulation,Kyushu University)

O-37 FBXL12 targets ALDHs for degradation in trophoblast stem cells to induce
Differentiation
Keiichi I. Nakayama(Department of Molecular and Cellular Biology, Medical Institute of
Bioregulation, Kyushu University)

10The 12th Stem Cell Research Symposium Program
O-38 The Lin28/let-7 axis regulates proliferation of hepatoblasts
Yasuo Takashima1, Maiko Terada1, Atsushi Suzuki1,2(1Division of Organogenesis and Regeneration, Medical Institute of
Bioregulation, Kyushu University, 2Core Research for Evolutional
Science and Technology (CREST), Japan Science and Technology
Agency)O-39 Establishment of the gene transduction into the primary intestinal organoid
identified the subpopulation of the stem cells in a crypt
Nobukatsu Horita1, Kiichiro Tsuchiya2, Ryohei Hayashi1,
Keita Fukushima1, Shuji Hibiya1, Masayoshi Fukuda1,
Yoshihito Kano1, Tomohiro Mizutani1, Yasuhiro Nemoto1, Shiro Yui1,
Ryuichi Okamoto2, Tetsuya Nakamura2, Mamoru Watanabe1(1Department of Gastroenterology and Hepatology, Graduate School,
Tokyo Medical and Dental University, 2Department of Advanced
Therapeutics for Gastrointestinal Diseases, Tokyo Medical and Dental
University)

Session 11 : Tissue Stem Cells (2)Chair

16：00～16：45

Daisuke Sugiyama(Department of Research and Development of Next Generation Medicine,
Faculty of Medical Sciences, Kyushu University)

O-40 Cell motion predicts epidermal stemness
Daisuke Nanba1, Fujio Toki1, Sota Tate2, Matome Imai2,
Natsuki Matsushita3, Hiroshi Toki4, Shigeki Higashiyama1,
Yann Barrandon5(1Proteo-Science Center, Ehime University, 2Graduate School of
Medicine, Ehime University, 3Translational Research Center, Ehime
University Hospital, 4Research Center for Nuclear Physics, Osaka
University, 5Laboratory of Stem Cell Dynamics, Ecole Polytechnique
Federale de Lausanne)
O-41 Defective maintenance of COL17A1 in hair follicle stem cells orchestrates hairfollicle aging
Hiroyuki Matsumura, Yasuaki Mohri, Nguyen Thanh Binh,
Hironobu Morinaga, Emi Nishimura(Department of Stem Cell Medicine, Medical Research Institute Tokyo
Medical and Dental University)
O-42 Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte
differentiation
Hiroyuki Nobusue1,2, Nobuyuki Onishi1, Takatsune Shimizu3,
Eiji Sugihara1, Yoshinao Oki2, Yuko Sumikawa2, Tatsuyuki Chiyoda1,
Koichi Akashi4, Koichiro Kano2, Hideyuki Saya1(1Division of Gene Regulation, Institute for Advanced Medical
Research, Keio University School of Medicine, 2Laboratory of Cell andTissue Biology, College of Bioresource Sciences, Nihon University,
3Department of Pathophysiology, School of Pharmacy andPharmaceutical Sciences, Hoshi University, 4Department of Medicine
and Biosystemic Science, Kyushu University Graduate School of
Medical Science)

Closing Remarks
Next Organizer

16：45～17：00
Issay Kitabayashi(Division of Hematological Malignancy National Cancer Center ResearchInstitute)11

The 12th Stem Cell Research Symposium Program

Poster Session
Session 1: Hematopoietic Stem Cells
P-1

Ezh2 is required for the maintenance of developmental stage-specific functions ofhematopoietic stem cells
Motohiko Oshima1, Satoru Miyagi1, Shuhei Koide1,
George Russel Wendt1, Yutaka Suzuki2, Atsushi Iwama1(1Department of Cellular and Molecular Medicine, Graduate School of
Medicine, Chiba University, 2Laboratory of Functional Genomics,
Department of Medical Genome Sciences, Graduate School of Frontier
Sciences, University of Tokyo)

P-2

Stem cell factor enhances generation of hematopoietic progenitors from humanpluripotent stem cells
Seok-Ho Hong1,3, Borim An1,3, Se-Ran Yang2,3(1Department of Internal Medicine, School of Medicine, Kangwon
National University, Chuncheon, 2Department of Thoracic andCardiovascular Surgery, School of Medicine, Kangwon National
University, Chuncheon, 3Stem Cell Institute, Kangwon National
University, Chuncheon, Korea)

P-3

FGF7 supports hematopoietic stem/progenitor cells and niche-dependent
myeloblastoma cells via autocrine action on bone marrow stromal cells
Satowa Tanaka1, Ruri Ishino1, Azusa Imanishi1, Masaya Yano1,
Keiji Matsui1, Kaori Minami1, Mami Nagai2, Natsumi Hasegawa1,
Shigetaka Asano3, Mitsuhiro Ito4
(1Kobe University Graduate School of Health Sciences, 2Waseda
University, 3Waseda University, Kobe University Graduate School of
Medicine, 4Kobe University Graduate School of Health
Sciences/Medicine, Rockefeller University)

P-4

Prospective isolation of human erythroid lineage-committed progenitors
Yasuo Mori1,2, Jun Seita2, James Chen2, John Pluvinage2,
Koichi Akashi1, Irving Weissman2(1Department of Medicine and Biosystemic Science, Graduate Schoolof Medical Sciences, Kyushu University, 2Institute for Stem Cell
Biology and Regenerative Medicine, Stanford University, CA, USA)

P-5

Geminin regulates transcription via chromatin remodeling to govern cellular
proliferation and differentiation
Yoshinori Ohno1, Shin’ichiro Yasunaga1, Toshiaki Kurogi1,
Kyoko Suzuki-Takedachi1, Mimoko Santo1, Motoaki Ohtsubo2,
Yoshihiro Takihara1(1Department of Stem Cell Biology, Research Institute for Radiation
Biology and Medicine, Hiroshima University, 2Department of Foodand Fermentation Science, Beppu University)

P-6

A novel approach for identification of hematopoietic stem cell population by
nucleostemin promoter activity
Mohamed A.E. Ali, Takayuki Hoshii, Yuko Tadokoro, Masaya Ueno,
Kazuhito Naka, Atsushi Hirao(Division of Molecular Genetics, Cancer Research Institute,
Kanazawa University)

12The 12th Stem Cell Research Symposium Program
P-7

EED, a non-catalytic subunit of PRC2, plays an essential role in maintenance ofadult hematopoietic stem cells
Kenichiro Ikeda, Takeshi Ueda, Hiroaki Honda(Department of Disease Model, Research Institute for Radiation
Biology and Medicine, Hiroshima University)

P-8

Establishment and genetic analysis of bone marrow mesenchymal cell clones
supporting proliferation of CD34+ umbilical cord blood cells
Tetsumi Yoshida1, Keichiro Mihara1, Tatsuji Mino1, Dario Campana2,
Yoshihiro Takihara3, Tatsuo Ichinohe1(1Department of Hematology/Oncology, Research Institute for
Radiation Biology and Medicine, Hiroshima University, 2Departmentof Pediatrics, National University of Singapore, 3Department of Stem
Cell Biology, Research Institute for Radiation Biology and Medicine,
Hiroshima University)

P-9

Eset regulates energy metabolism in hematopoietic stem and progenitor cells
Shuhei Koide1, Keiyo Takubo2, Motohiko Oshima1, Satoru Miyagi1,
Shogo Yabata1, George Wendt1, Toshio Suda2, Atsushi Iwama1(1Department of Cellular and Molecular Medicine, Graduate School of
Medicine, Chiba University, 2Department of Cell Differentiation, The
Sakaguchi Laboratory of Developmental Biology, Keio University
School of Medicine)P-10 Antibody-free flow cytometric analysis of zebrafish neutrophil by DNA-binding
DRAQ5 dye and lectin
Kasem Kulkeaw1, Tomoko Inoue1, Kanitta Srinoun2, Tohru Ishitani3,
Yuka Tanaka1, Keai Sinn Tan1, Takaaki Kanemaru4,
Daisuke Sugiyama1(1Center for Clinical and Translational Research, Kyushu University
Hospital, 2Faculty of Allied Health Sciences, Prince of Songkla
University, Thailand, 3Division of Cell Regulation Systems,
Department of Post-Genome Science Center, Medical Institute of
Bioregulation, Kyushu University, 4Morphology Core Unit, Kyushu
University Hospital)
P-11 Histone acetyltransferase MORF is essential for maintenance of hematopoietic
stem cells
Takuo Katsumoto, Issay Kitabayashi(Hematological Malignancy Division, National Cancer Center
Research Institute)P-12 The herbal drug ninjin’yoeito accelerates myelopoiesis but not erythropoiesis in
vitro
Tomoko Inoue1, Kasem Kulkeaw1, Kanitta Muennu1,2,3,
Yuka Tanaka4,5, Yoichi Nakanishi5, Daisuke Sugiyama1(1Department of Research and Development of Next Generation
Medicine, Faculty of Medical Sciences, Kyushu University,
2Thalassemia Research Center, Institute of Molecular Biosciences,
Mahidol University, 3Faculty of Medical Technology, Prince of Songkla
Univers, 4Department of Cell Biology, Faculty of Medicine, Fukuoka
University, 5Center for Clinical and Translational Research, Kyushu
University Hospital)

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The 12th Stem Cell Research Symposium Program
P-13 Three-dimensional analysis of hematopoietic development in the mouse embryonichead
Kazuhide Iizuka1, Tomomasa Yokomizo1, Motomi Osato2,
Tomoiku Takaku1, Norio Komatsu1(1Department of Hematology, Juntendo University School of Medicine,
2Cancer Science Institute of Singapore, National University ofSingapore)
P-14 The pro-phagocytic calreticulin on hematopoietic stem cell in the pathogenesis of
JAK2 non-mutated myeloproliferative neoplasms
Shinya Daitoku, Katsuto Takenaka, Takuji Yamauchi, Ayano Yurino,
Fumiaki Jinnouchi, Kohta Miyawaki, Koichi Akashi(Department of Medicine and Biosystemic Science, Kyushu University
Graduate School of Medical Sciences)P-15 Jmjd3, a histone demethylase, is required for the functional integrity ofhematopoietic stem cells in mice
Yuichiro Nakata, Takeshi Ueda, Norimasa Yamasaki, Hiroaki Honda(Department of Disease Model, Research Institute for Radiation
Biology and Medicine, Hiroshima University)
P-16 Embryonic spleen niche accelerates erythropoiesis through SCF and IGF-1
secretion
Keai Sinn Tan1,2, Tomoko Inoue-Yokooc1, Kasem Kulkeaw1,
Wai Feng Lim2, Sarinthip Preedagasamzin1, Yuka Tanaka3,
Mei I Lai2,Daisuke Sugiyama1,3(1Department of Research and Development of Next Generation
Medicine, Faculty of Medical Sciences, Kyushu University,
2Department of Pathology, Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia, Malaysia, 3Center for Clinical andTranslational Research, Kyushu University Hospital)
P-17 The generation of Runx1 enhancer, eR1(+24m), driven CreERT2 transgenic micefor hematopoietic stem cells-specific gene targeting, imaging and transgenesis
Cai Ping Koh, Chelsia Qiuxia Wang, Cherry Ee Lin Ng, Linsen Du,
Zakir Hossain, Motomi Osato(Cancer Science Institute of Singapore, National University ofSingapore)

Session 2: Leukemia and Cancer Stem Cells
P-18 Transcription factor Lhx2 inhibits proliferation of T-cell acute lymphoblastic
leukemia-derived cells
Kazuya Miyashita1,2, Kenji Kitajima1, Takahiko Hara1,2(1Stem Cell Project, Tokyo Metropolitan Institute of Medical Science,
2Graduate School of Tokyo Medical and Dental University)
P-19 Autophagy activated by TIM-4-AMPKα interaction suppresses
chemotherapyinduced antitumor immunity
Muhammad Baghdadi, Masahisa Jinushi(Hokkaido University Institute for Genetic Medicine)P-20 C6 glioma SP and MP cells have different metabolism on the ALA-PpIX-heme
pathway: an implication for self-creating cancer stem cell niche
Wenqian Wang1, Kouichi Tabu1, Yuta Sugiyama2, Yuichiro Hagiya2,
Shun-ichiro Ogura2, Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute,Tokyo Medical and Dental University (TMDU), 2Graduate School of
Bioscience and Biotechnology, Tokyo Institute of Technology)

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The 12th Stem Cell Research Symposium Program
P-21 Heterogeneity within CD204+ tumor-associated macrophages induced by C6 glioma
stem cells
Yasuhiro Kokubu, Kouichi Tabu, Nozomi Muramatsu,
Yoshitaka Murota, Ryosuke Kimura, Tetsuya Taga
(Department of Stem Cell Regulation, Medical Research Institute,Tokyo Medical and Dental University (TMDU))
P-22 CD74-NRG1 is a potential oncoprotein that promotes cancer stem cell properties
Takahiko Murayama1,2, Takashi Nakaoku3, Koji Tsuta4, Masato Enari5,
Tatsunori Nishimura1, Kana Tominaga1, Asuka Nakata1,6,
Arinobu Tojo7, Sumio Sugano2, Takashi Kohno3, Noriko Gotoh1,6(1Division of Molecular Therapy, Molecular targets laboratory,
Institute of Medical Science, University of Tokyo, 2Laboratory of
Functional Genomics, Department of Medical Genome Sciences,
Graduate School of Frontier Sciences, University of Tokyo, 3Divisionof Genome Biology, National Cancer Center Research Institute,
4Pathology Division, National Cancer Center Research Institute,
5Division of Refractory Cancer Research, National Cancer Center
Research Institute, 6Division of Cancer Cell Biology, Cancer ResearchInstitute of Kanazawa University, Kanazawa University, 7Division of
Molecular Therapy, Advanced Clinical Research Center, Institute ofMedical Science, University of Tokyo)
P-23 Insulin-like growth factor regulates breast cancer stem cell properties
Kana Tominaga1, Teppei Shimamura2, Kunihiko Hinohara1,
Hiroaki Fukuda1, Hajime Kanauchi3, Seiichiro Shimizu4,
Kotoe Nishioka5, Ei-ichi Tsuji5, Kei-ichiro Tada5, Yohei Shimono6,
Hideshi Ishii7, Hideyuki Saya8, Masaki Mori7, Toshihisa Ogawa5,
Satoru Miyano2, Arinobu Tojo1, Noriko Gotoh1,9(1Division of Molecular Therapy, Institute of Medical Science, The
University of Tokyo, 2Laboratory of DNA Information Analysis,
Institute of Medical Science, The University of Tokyo, 3Department ofBreast and Endocrine Surgery, Showa General Hospital, 4Departmentof Pathology Diagnosis, Showa General Hospital, 5Department ofBreast and Endocrine Surgery, Graduate School of Medicine, The
University of Tokyo, 6Graduate School of Medicine, Kobe University,
7Department of Gastroenterological Surgery, Graduate School of
Medicine, Osaka University, 8Division of Gene Regulation, Institutefor Advanced Medical Research, Graduate School of Medicine, Keio
University, 9Division of Cancer Cell Biology, Cancer ResearchInstitute, Kanazawa University)
P-24 Novel molecular mechanisms of acquired resistance to gefitinib in lungadenocarcinoma
Asuka Nakata1, Ryo Yoshida2, Rui Yamaguchi3, Mai Yamauchi3,
Yoshinori Tamada3, Andre Fujita3, Teppei Shimamura3,
Seiya Imoto3,Tomoyuki Higuchi2, Masaharu Nomura4, Seiji Yano5,
Satoru Miyano3,Noriko Gotoh1,3(1Division of Cancer Cell Biology, Cancer Research Institute,
KanazawaUniversity, 2The Institute of Statistical Mathematics,
3Institute of MedicalScience, The University of Tokyo, 4Tokyo Medical
University Hospital,5Cancer Research Institute, Kanazawa
University)

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The 12th Stem Cell Research Symposium Program
P-25 Maintenance of stemness of breast cancer stem-like cells by FRS2beta, a feedback
inhibitor for ErbB, during mammary tumorigenesis
Yukino Machida1, Daisuke Iejima1, Anna Mizutani1, Natsuko Kimura1,
Reiko Sakamoto2, Yusuke Inoue3, Nobutaka Kobayashi4, Naoki Itano4,
Arinobu Tojo1, Nobuaki Yoshida2, Ko-ichi Akashi5, Hideyuki Saya6,
Issay Kitabayashi7, Noriko Gotoh1,8(1Division of Molecular Therapy, Institute of Medical Science,
University of Tokyo, 2Division of Developmental Genetics, Institute ofMedical Science, University of Tokyo, 3Department of Diagnostic
Radiology, Kitasato University School of Medicine, 4Medical
Department, Shinsyu University, 5Department of Medicine andBiosystemic Science, Kyusyu University, 6Division of Gene Regulation,
Institute for Advanced Medical Research, School of Medicine, Keio
University, 7Division of Hematological Malignancy, National Cancer
Center Research Institute, 8Division of Cancer Cell Biology, Cancer
Research Institute, Kanazawa University)
P-26 FRS2beta, a feedback inhibitor for EGF receptor/ErbB family, may control
malignancy of breast cancer, in association with overexpression of a polycomb
protein, Ezh2
Natsuko Kimura1, Yukino Machida1, Tatsunori Nishimura1,
Arinobu Tojo1, Noriko Gotoh1,2(1Division of Molecular Therapy, Institute of Medical Science,
University of Tokyo, 2Division of Cancer Cell Biology, Cancer ResearchInstitute, Kanazawa University)
P-27 Sphingosine-1-phosphate induces cancer stem cell proliferation via a Notch
ligandindependent Notch activation
Naoya Hirata, Shigeru Yamada, Yuko Sekino, Yasunari Kanda(Div. Pharmacol, NIHS)

Session 3: iPS/ES Cells
P-28 Induction of primordial germ cell-like cells from mouse embryonic stem cells by
ERK signal inhibition
Mika Odamoto1, Tohru Kimura1,2, Hiroshi Ohta3, Keita Fujikawa1,
Ayako Isotani4, Katsuhiko Hayashi3,5, Masaru Okabe4,
Takashi Shinohara6, Mitinori Saitou3,7, Tohru Nakano2,8(1Department of Stem Cell Biology, Kitasato University School of
Science, 2Graduate School of Frontier Biosciences, and Department of
Pathology, Medical School, Osaka University, 3Department of
Anatomy and Cell Biology, Graduate School of Medicine, Kyoto
University, 4Research Institute for Microbial Diseases, Osaka
University, 5PRESTO, Japan Science and Technology Agency (JST),
6Department of Molecular Genetics, Graduate School of Medicine,
Kyoto University, 7ERATO, JST, 8CREST, JST)
P-29 Analysis of tetraploid embryonic stem cells in mice
Hiroyuki Imai1,2, Kiyoshi Kano1,2, Wataru Fujii3, Ken Kusakabe2,
Yasuo Kiso2(1Laboratory of Developmental Biology, Joint Faculty of Veterinary
Medicine, Yamaguchi University, 2Laboratory of Veterinary Anatomy,
Joint Faculty of Veterinary Medicine, Yamaguchi University,
3Laboratory of Applied Genetics, Graduate School of Agricultural andLife Science, University of Tokyo)

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The 12th Stem Cell Research Symposium Program
P-30 In vitro embryotoxicity testing based on human iPS cells
Nobuo Aikawa, Atsushi Kunisato, Katsumi Takaba, Kenji Nagao,
Kinya Ohgami, Hideaki Kusaka(R&D Division, Kyowa Hakko Kirin Co., Ltd.)
P-31 Promotion of iPS cell induction by Akt signaling activation
Keita Fujikawa, Tohru Kimura(Department of Stem cell Biology, Kitasato University School of
Science)P-32 Sox17-transduction imparts fetal hematopoietic cells with the myeloid-restricteddifferentiation potential
Maha Anani1, Ikuo Nobuhisa1, Mitsujiro Osawa2, Atsushi Iwama3,
Kaho Harada1, Kiyoka Saito1, Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute,Tokyo Medical and Dental University (TMDU), 2Clinical Application
Department, Center for iPS Cell Research and Application (CiRA),
Kyoto University, 3Department of Cellular and Molecular Medicine,
Graduate School of Medicine, Chiba University)
P-33 Improved hematopoietic differentiation of common marmoset embryonic stem cells
Takenobu Nii, Tomotoshi Marumoto, Saori Yamaguchi,
Hirotaka Kawano, Jiyuan Liao, Kenzaburo Tani
(Division of Molecular and Clinical Genetics, Medical Institute of
Bioregulation, Kyushu University)
P-34 Role of an atypical Polycomb Repressive Complex 1 (PRC1) involving MBLR and
Mga/Max in repressing meiosis-related genes in mouse ES cells
Mitsuhiro Endoh, Takaho Endoh, Haruhiko Koseki(RIKEN Center for Integrative Medical Sciences)P-35 The Nanog/Zfp57 axis regulates anchorage-independent growth
Hiroshi Koide1, Yuhki Tada1, Yukari Yamaguchi2,
Hiroyuki Takamura2, Tadayuki Akagi1, Tetsuo Ohta2, Takashi Yokota1(1Department of Stem Cell Biology, Graduate School of Medical
Sciences, Kanazawa University, 2Department of Gastroenterological
Surgery, Graduate School of Medical Sciences, Kanazawa University)
P-36 Establishment of disease model using induced pluripotent stem cells derived
Niemann-Pick disease type C
Makoto Hamasaki1, Minami Soga1, Kaori Yoneda2,
Kimitoshi Nakamura2, Muneaki Matsuo3, Tetsumi Irie4, Fumio Endo2,
Takumi Era1
(1Department of Cell Modulation, Institute of Molecular Embryology
and Genetics, Kumamoto University, 2Department of Pediatrics,
Graduate School of Medical Sciences, Kumamoto University,
3Department of Pediatrics, Saga University, Faculty of Medicine,
4Department of Clinical Chemistry and Informatics, Graduate Schoolof Pharmaceutical Sciences, Kumamoto University)
P-37 Visualization and characterization of Tbx18 positive cells, derived from mouse ES
cells
Natsumi Nakazawa, Nobuhito Ikeda, Yasuaki Shirayoshi,
Ichiro Hisatome(Division of Regenerative Medicine and Therapeutics, Institute ofRegenerative Medicine and Biofunction, Graduate School of Medical
Sciences, Tottori University)

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The 12th Stem Cell Research Symposium Program
P-38 Treatment approach for HPP via genetically modified patient’s iPS cells and
iPSMSCs
Yasuaki Oda1, Mika Tadokoro2, Shunsuke Yuba2, Hajime Ohgushi2,
Takeshi Taketani3, Takumi Era1
(1Department of Cell Modulation, Institute of Molecular Embryology
and Genetics, Kumamoto University, 2Tissue Engineering ResearchGroup, Health Research Institute, National Institute of Advanced
Industrial Science and Technology, 3Division of Blood Transfusion,
Shimane University Hospital)

Session 4: Tissue Stem Cells and others
P-39 Therapeutic effects of human umbilical cord-derived mesenchymal stem cells inexperimental stroke
Jihwan Song2, Seung-Hun Oh1, Jeong-Eun Roh2, Chunggab Choi2,
Yongwoo Jeong2, Nayeon Lee2, Da-Jeong Chang2, Iksoo Jeon2,
Hyun Sook Kim1, Youngjun Lee3, Yong-Soo Choi3, Ok-Joon Kim1
(1Department of Neurology, CHA Bundang Medical Center, CHA
University, Gyeonggi-do, Korea, 2CHA Stem Cell Institute,
Department of Biomedical Science, CHA University, Seoul, Korea,
3Department of Applied Bioscience, CHA University, Seongnam-si,
Korea)
P-40 Evaluation of stem cell characteristics of murine bone-derived small cells
Ryusuke Nakatsuka, Ryuji Iwaki, Yoshikazu Matsuoka,
Keisuke Sumide, Tatsuya Fujioka, Yutaka Sasaki, Yoshiaki Sonoda(Department of Stem Cell Biology and Regenerative Medicine,
Graduate School of Medical Science, Kansai Medical University)
P-41 Pluripotent stem cells derived from mouse primordial germ cells by small moleculecompounds
Tohru Kimura1, Keita Fujikawa1, Mika Odamoto1, Masahito Ikawa2,
Kuniya Abe3, Toru Nakano4(1Department of Stem Cell Biology, Kitasato University School of
Science, 2Research Institute for Microbial Diseases, Osaka University,
3RIKEN BioResource Center, 4Graduate School of Frontier
Biosciences, Medical School, Osaka University)
P-42 Transcriptional regulatory networks underlying reprogramming of spermatogonial
stem cells to pluripotent states
Kye-Seong Kim1, Jinhyuk Bhin2, Hyung Joon Kim3, Hoe Su Jeong1,
Dong Ryul Lee3, Daehee Hwang2,4,5(1Hanyang University Graduate School of Biomedical Science andEngineering, Seoul, Korea, 2Department of Chemical Engineering,
POSTECH, Pohang, Korea, 3Fertility Center of CHA Gangnam
Medical Center, College of Medicine, CHA University, Seoul, Korea,
4School of Interdisciplinary Bioscience and Bioengineering,
POSTECH, Pohang, Korea, 5Division of Integrative Biosciences andBiotechnology, POSTECH, Pohang, Korea)

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The 12th Stem Cell Research Symposium Program
P-43 TLR9 signaling in microglia suppresses seizure-induced aberrant neurogenesis in
the adult hippocampus
Taito Matsuda1, Naoya Murao1,2, Yuki Katano1,2, Berry Juliandi1,3,
Shizuo Akira4,5, Taro Kawai6, Kinichi Nakashima1(1Department of Stem Cell Biology and Medicine, Graduate School of
Medical Sciences, Kyushu University, 2Laboratory of Gene Regulation
Research, Graduate School of Biological Sciences, Nara Institute of
Science and Technology (NAIST), 3Department of Biology, Bogor
Agricultural University, Bogor, Indonesia., 4Laboratory of Host
Defense, World Premier International Immunology Frontier ResearchCenter, Osaka University, 5Department of Host Defense, ResearchInstitute for Microbial Diseases, Osaka University, 6Laboratory of
Molecular Immunobiology, Graduate School of Biological Sciences,
NAIST.)
P-44 Analysis of mechanisms underlying neurogenesis in the adult hippocampus
regulated by hemimethylated DNA recognition factor, Np95/Uhrf1
Naoya Murao1,2, Taito Matsuda1, Haruhiko Koseki3,
Masakazu Namihira4, Kinichi Nakashima1(1Stem cell Biology and Medicine, Department of Stem cell Biology
and Medicine, Graduate School of Medical Sciences, Kyushu
University, 2Laboratory of Gene Expression Research, Graduate
School of Biological Science, NAIST, 3Developmental Genetics, Riken
Research Center for Allergy and Immunology, 4Neuroscience ResearchInstitute, AIST)
P-45 Development of a new method for the simultaneous integration of multiple vectors
into human/mouse artificial chromosome
Teruhiko Suzuki1, Manami Kawaguchi1, Mitsuo Oshimura2,3,
Takahiko Hara1(1Stem Cell Project, Tokyo Metropolitan Institute of Medical Science,
2Department of Biomedical Science,Graduate School of Medical
Sciences, Tottori Uniersity, 3Chromosome Engineering ResearchCenter, Tottori Uniersity)
P-46 The investigation on possibility of existence of endothelial stem-like cell populationin kidney
Keitaro Yamane(Department of signal Transduction, Research Institute for Microbial
Diseases, Osaka University)
P-47 Functional analysis of MeCP2, the Rett syndrome responsible factor, in neuralstem cells
Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie,
Kinichi Nakashima(Stem Cell Biology and Medicine, Department of Stem cell Biology
and Medicine, Graduate School of Medical Sciences, Kyushu
University)
P-48 Dual roles of cyclin D1 in self-renewal of neural stem cells: promotion of cellproliferation and inhibition of glial differentiation
Norihisa Bizen1, Toshihiro Inoue2, Takeshi Shimizu3, Koichi Tabu1,
Tetsushi Kagawa1, Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute,Tokyo Medical and Dental University (TMDU), 2Department ofOphthalmology, Faculty of life Sciences, Kumamoto University,
3Division of Neurobiology and Bioinformatics, National Institute forPhysiological Sciences)19