June 1 (Fri.)–June 2 (Sat.), 2018

8:00

The 1st Day : Friday, June 1
Centennial HallThe 2nd Day : Saturday, June 2
Centennial Hall

8:00

9:00

9:00

9:30~10:55▶P.6

Session 5

10:00

10:00

Tissue stem cells 2
O-16~O-20

Chair : Kinichi Nakashima
11:00

10:55~11:15
11:15~12:20

11:00

Coffee BreakSession 6▶P.6

Reprogramming and pluripotent stem cells 2
O-21~O-23

12:00

12:00

Chair : Hitoshi Niwa
12:20~13:30

13:00

13:00~13:05
13:05~14:15

Opening Remarks
Session 1

Hematopoietic stem cells 1

Lunch Time / Poster Session▶P.3
13:30~15:05

O-01~O-04
14:15~14:35
14:35~15:35

O-24~O-29

15:35~16:40▶P.3

O-05~O-07

15:05~15:20

Chair : Takashi Shinohara

15:20~16:25

Session 3▶P.4

Session 4

▶P.8

16:00

Chair : Hitoshi Takizawa
16:25~17:10

Coffee Break

17:00~18:15

Session 8

O-30~O-33

O-08~O-11

16:40~17:00

15:00

Coffee BreakHematopoietic stem cells 2

Reprogramming and pluripotent stem cells 1
Chair : Katsuhiko Hayashi

17:00

Chair : Issay Kitabayashi
Takahiro Maeda

Germline stem cells

15:00

16:00

14:00

Cancer stem cells

Coffee BreakSession 2▶P.7

Session 7

Chair : Atsushi Iwama
Motomi Osato

14:00

13:00

Session 9

MicroenvironmentO-34~O-36▶P.4

Chair : Keiyo Takubo
17:10~17:20

▶P.9

17:00

Closing Remarks

Tissue stem cells 1
O-12~O-15

Chair : Atsushi Hirao

18:00
18:15~18:30

18:00

General Meeting

18:30~19:30

19:00

Reception / Poster viewing

19:00

20:00

20:00

16th Stem Cell Research Symposium2June 1 (Fri.)–June 2 (Sat.), 2018

The 1st Day
13:00～13:05

Opening Remarks

Organizer Fumio Arai

(Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University)

13:05～14:15

Session 1: Hematopoietic stem cells 1

Chair Atsushi Iwama（Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba
University）

Motomi OsatoO-01 Fetal bile acid regulates multiple organ development
Kenichi Miharada(Div. Molecular Medicine and Gene Therapy, Lund University, Sweden)(Columbia Stem Cell Initiative, Department of Genetics and Development,
Columbia University, New York, NY 10032, USA)

O-03 Acute gut inflammation shifts early hematopoiesis toward myelopoiesis
Yoshikazu Hayashi, Hitoshi Takizawa(International Research Center for Medical Sciences, Kumamoto University,
Kumamoto, 860-0811 Japan)

O-04 Phf6 restricts the self-renewal of hematopoietic stem cells via regulation of
Nr4a1 expression
Satoru Miyagi1, Patrycja Sroczynska 2 , Yuko Kato1, Motohiko Oshima1,
Kristian Helin2 , Atsushi Iwama1(1Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University, 2Biotech Research and Innovation Centre (BRIC), University of
Copenhagen)Coffee Break

14:15～14:35

Session 2: Germline stem cells

14:35～15:35

Chair Takashi Shinohara（Department of Molecular Genetics, Graduate School of Medicine, Kyoto University）(1Research Institute for Microbial Diseases, Osaka University, 2Whitehead
Institute, 3MIT Department of Biology, 4HHMI)

3

16th Stem Cell Research Symposium

Abstract / Poster

O-05 Retinoic acid signal for continuous sperm production: Exit from the stem cellpool toward terminally differentiated cells
Tsutomu Endo1, Dirk de Rooij2 , David Page2,3,4Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-02 Inflammation-produced TNFα protects hematopoietic stem cells fromnecroptosis and promotes hematopoietic regeneration
Masayuki Yamashita, Emmanuelle Passegué

Program / Poster(Cancer Science Institute of Singapore, National University of Singapore/International
Research Center for Medical Sciences, Kumamoto University)

Program / 1st Day Program / 2nd Day

Friday, June 1.

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

June 1 (Fri.)–June 2 (Sat.), 2018

O-06 Genomic imprinting by maternal histones
Azusa Inoue1, Zhiyuan Chen2 , Yi Zhang2(1RIKEN Center for Integrative Medical Sciences, 2Harvard Medical School/
Boston Childrens Hospital)

O-07 The role of H3K27 demethylases in the regulation of spermatogonial stem cells
Naoki Iwamori1, Sakurako Shima1, Tokuko Iwamori2 , Hiroshi Iida1(1Laboratory of Zoology, Graduate School of Bioresource and Bioenvironmental
Sciences, Kyushu University, 2Department of Biomedicine, Graduate School of
Medical Sciences, Kyushu University)

Session 3: Reprogramming and pluripotent stem cells 1

15:35～16:40

Chair Katsuhiko Hayashi（Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University）

O-08 Higher-order chromatin features in human pluripotent stem cells
Takuya Yamamoto(Department of Life Science Frontiers, Center for iPS Cell Research andApplication, Kyoto University)

O-09 Zfp281 shapes the transcriptome of trophoblast stem cells and regulates
placental development
Takashi Ishiuchi(Division of Epigenomics and Development, Medical Institute of Bioregulation,
Kyushu University)

O-10 The intrinsic genetic program that drives trophoblast differentiation fromhuman ES cells
Masatoshi Ohgushi(Institute for Frontier and Medical Science, Kyoto University)

O-11 Ribosome incorporation into somatic cells promotes lineagetransdifferentiation towards multipotency
Kunimasa Ohta, Mohammad Badrul Anam, Shah Adil Ishtiyaq Ahmad,
Naofumi Ito(Graduate School of Life Sciences, Kumamoto University)

Coffee Break

16:40～17:00

Session 4: Tissue stem cells 1

17:00～18:15

Chair Atsushi Hirao（Division of Molecular Genetics, Cancer Research Institute, Kanazawa University）

O-12 Hox genes control muscle stem cell function in a body-region-specific manner
Yusuke Ono(Musculoskeletal Molecular Biology Research Group, Nagasaki University
Graduate School of Biomedical Sciences)

O-13 Derivation of human trophoblast stem cells
Hiroaki Okae, Takahiro Arima(Department of Informative Genetics, Tohoku University Graduate School of
Medicine)

16th Stem Cell Research Symposium

4June 1 (Fri.)–June 2 (Sat.), 2018

(Tokyo Institute of Technology)

O-15 Different contribution of quiescent stem cells to the maintenance of intestinal,
gastric and neoplastic epithelia
Tsunaki Higa, Yasutaka Okita, Akinobu Matsumoto, Hirokazu Nakatsumi,
Keiichi I. Nakayama(Department of Molecular and Cellular Biology, Medical Institute of Bioregulation,
Kyushu University)

18:15～18:30

General Meeting

Chief Director Koichi Akashi(Department of Medicine and Biosystemic Science, Faculty of Medicine, Kyushu University)

Program / Poster

18:30～19:30

Reception / Poster viewing

Program / 1st Day Program / 2nd Day

O-14 Osteoblast production by reserved progenitor cells in zebrafish boneregeneration and maintenance
Atsushi Kawakami

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)
Abstract / Poster

5

16th Stem Cell Research SymposiumAbstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

June 1 (Fri.)–June 2 (Sat.), 2018

Saturday, June 2.

The 2nd Day
9:30～10:55

Session 5: Tissue stem cells 2

Chair Kinichi Nakashima（Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University）

O-16 Regulated IFN-signal preserves stemness of intestinal stem-cells by restricting
secretory-cell differentiation
Taku Sato, Toshiaki Ohteki(Department of Biodefense Research, Medical Research Institute, Tokyo Medical
and Dental University)

O-17 Fetalization of colonic epithelium mediated by YAP/TAZ links ECM
remodeling to tissue regeneration
Shiro Yui1, Ryuichi Okamoto1, Kiichiro Tsuchiya 2 , Tetsuya Nakamura 3 ,Mamoru Watanabe2(1Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental
University, 2Department of Gastroenterology and Hepatology, Tokyo Medical and
Dental University, 3Department of Advanced Therapeutics in GI Diseases, Tokyo
Medical and Dental University)

O-18 Regulatory Mechanism of Neural Stem Cells Revealed by Optical Manipulationof Gene Expression
Itaru Imayoshi(Graduate School of Biostudies, Kyoto University)

O-19 Decoding mouse embryonic neural stem cell fate by BMP2 responsivenessSayako Katada, Mizuki Honda, Kinichi Nakashima(Graduate School of Medical Sciences, Kyushu University)

O-20 Polycomb Group Proteins Ring1A/B regulate early-stage patterning in thetelencephalic development
Hikaru Eto, Yusuke Kishi, Yukiko Gotoh(Graduate School of Pharmaceutical Sciences, The University of Tokyo)

10:55～11:15

Coffee BreakSession 6: Reprogramming and pluripotent stem cells 2

11:15～12:20

Chair Hitoshi Niwa

（Department of Pluripotent Stem Cell Biology, Institute of Molecular Embryology andGenetics, Kumamoto University）

O-21 Flexible generation of male germ cells from female somatic cells of anendangerd Tokudaia osimensis
Arata Honda(Institute of Laboratory Animals, Kyoto University Graduate School of Medicine)

O-22 Transcriptome Manipulation to Facilitate the Differentiation of Human
Pluripotent Stem Cells
Tomohiko Akiyama, Minoru Ko(Keio University School of Medicine)

16th Stem Cell Research Symposium

6June 1 (Fri.)–June 2 (Sat.), 2018

(1Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ,
UK, 2Mathematical Institute, University of Oxford, Oxford OX2 6GG, UK,
3
Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University, Fukuoka 812-8582, Japan)

Lunch Time / Poster Session

12:20～13:30

Session 7: Cancer stem cells

13:30～15:05

Chair Issay Kitabayashi（Division of Hematological Malignancy, National Cancer Center Research Institute）

Takahiro Maeda

O-24 Identification of BCAAs metabolism pathway as a common machinery for
maintaining the stemness of human acute leukemia
Yoshikane Kikushige, Koichi Akashi(Kyushu University)(1Division of Hematological Malignancy, National Cancer Center ResearchInstitute, 2Department of Orthopaedic Surgery, Graduate School of Medical
Sciences, Kyushu University, 3Oncology Laboratories, Daiichi Sankyo Co., Ltd.,
4
Oncology Clinical Development Department, Daiichi Sankyo Co., Ltd.,
5Functional Genomics and Proteomics Research Group, Discovery Science andTechnology Department, Daiichi Sankyo RD Novare Co., Ltd.)

O-26 Blockade of PAI-1 activity increases therapeutic susceptibility of leukemicstem cells
Takashi Yahata1, Ibrahim Abd Aziz1, Toshio Miyata 2 , Kiyoshi Ando1(1Tokai University School of Medicine, 2Tohoku University Graduate School of
Medicine)

O-27 Lineage-specific RUNX2 super enhancer activates MYC via a chromosomaltranslocation and promotes the development of BPDCN
Sho Kubota1, Motomi Osato1,2 , Goro Sashida1(1International Research Center for Medical Sciences, Kumamoto University,
2
Cancer Science Institute of Singapore, National University of Singapore)(1Department of Hematology and Oncology, Osaka University Graduate School of
Medicine, Suita, Japan, 2Department of Vascular Physiology, Research InstituteNational Cerebral and Cardiovascular Center, Suita, Japan, 3Department of
Immunology and Cell Biology, Osaka University Graduate School of Medicine,
Suita, Japan)

7

16th Stem Cell Research Symposium

Abstract / Poster

O-28 Variable Expression Levels of the Hematopoietic Stem Cell Surface Antigen
ESAM Depict Heterogeneity and Fluctuations in Leukemic Stem Cells
Yasuhiro Shingai1, Takafumi Yokota1, Takayuki Ozawa1, Tomoaki Ueda1,
Yukiko Doi1, Tomoaki Ishibashi2 , Takao Sudo3 , Michiko Ichii1,
Hirohiko Shibayama1, Yuzuru Kanakura1

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-25 Dual inhibition of EZH1/2 depletes stem cells and over-activates WNT
signaling in multiple myeloma
Makoto Nakagawa1,2 , Takuo Katsumoto1, Kazutsune Yamagata1,
Yoko Ogawara1, Ayuna Hattori1, Yukiko Aikawa1, Daisuke Honma3 ,Kazushi Araki4 , Tatsuya Inoue5, Ayako Kato5, Koichiro Inaki5,
Chisa Wada5, Yoshimasa Ono5, Yasuharu Nakashima 2 , Issay Kitabayashi1

Program / Poster(Center for Cellular and Molecular Medicine, Kyushu University Hospital)

Program / 1st Day Program / 2nd Day

O-23 Stochastic models of stem cell differentiation
Ben D. MacArthur1, Patrick S. Stumpf1, Rosanna C. G. Smith1,
Colin P. Please2 , Sam D. Howison2 , Fumio Arai3

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

June 1 (Fri.)–June 2 (Sat.), 2018

O-29 ASXL1 mutation revealed impaired hematopoiesis caused by derepression of
p16Ink4a through aberrant histone modification
Masahiro Uni1,2 , Yosuke Masamoto1,2 , Tomohiko Sato1,2 ,Yasuhiko Kamikubo1,2 , Shunya Arai1,2 , Eiji Hara3,4 , Mineo Kurokawa1,2(1Department of Hematology and Oncology, Graduate School of Medicine, The
University of Tokyo, 2Department of Transfusion Medicine, The University ofTokyo Hospital, 3Department of Molecular Microbiology, Research Institute forMicrobial Diseases, Osaka University, 4The Cancer Institute, Japanese Foundation
for Cancer Research)

Coffee Break

15:05～15:20

Session 8: Hematopoietic stem cells 2

15:20～16:25

Chair Hitoshi Takizawa（International Research Center for Medical Sciences, Kumamoto University）

O-30 Thrombopoietin mediates metabolic priming of hematopoietic stem cells for
rapid megakaryocyte lineage differentiation
Ayako Nakamura-Ishizu1, Takayoshi Matsumura1,
A’Qilah Banu Bte Abdul Majeed1, Terumasa Umemoto2 , Toshio Suda1(1National University of Singapore, Cancer Science Institute, 2International
Research Center for Medical Sciences, Kumamoto University)

O-31 Metabolic regulation of hematopoietic stem cells by O-linked
N-acetylglucosamine transferase
Koichi Murakami1,2 , Daisuke Kurotaki3 , Wataru Kawase3 , Shunsuke Soma1,
Yumi Fukuchi1, Hiroyoshi Kunimoto2 , Ryusuke Yoshimi2 , Shuhei Koide4 ,Motohiko Oshima4 , Mayumi Oda 5, Minoru Ko5, Noriyo Hayakawa6 ,Tomomi Matsuura6 , Takako Hishiki6 , Kiichi Yanagisawa7, Miho Haraguchi7,
Hiroshi Kobayashi7, Yoshitoshi Atobe8 , Kengo Funakoshi8 , Atsushi Iwama4 ,Keiyo Takubo7, Shinichiro Okamoto1, Tomohiko Tamura3 ,Hideaki Nakajima 2(1Division of Hematology, Department of Internal Medicine, Keio University Schoolof Medicine, 2Department of Stem Cell and Immune Regulation, Yokohama City
University Graduate School of Medicine, 3Department of Immunology, Yokohama
City University Graduate School of Medicine, 4Department of Cellular andMolecular Medicine, Graduate School of Medicine, Chiba University, 5Department
of Systems Medicine, Keio University School of Medicine, 6Department ofBiochemistry, Keio University School of Medicine, 7Department of Stem Cell
Biology, Research Institute, National Center for Global Health and Medicine,8
Department of Neuroanatomy, Yokohama City University School of Medicine)O-32 Hlf expression marks developmental pathway for hematopoietic stem cells, but
not for erythroid-myeloid progenitors
Tomomasa Yokomizo1, Naoki Watanabe2 , Terumasa Umemoto1,
Tomoiku Takaku2 , Mohamed Gaber1, Seiichi Mori3 , Mineo Kurokawa4 ,Daniel G Tenen5, Toshio Suda1, Motomi Osato1, Norio Komatsu2(1IRCMS, Kumamoto University, 2Department of Hematology, Juntendo University
School of Medicine, 3Cancer Institute of Japanese Foundation for Cancer Research,
4
Department of Hematology and Oncology, The University of Tokyo, 5CSI,National University of Singapore)

16th Stem Cell Research Symposium

8June 1 (Fri.)–June 2 (Sat.), 2018

(Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University)

16:25～17:10

Session 9: Microenvironment

Chair Keiyo Takubo（Department of Stem Cell Biology, Research Institute, National Center for Global Healthand Medicine）

O-34 Adipsin is an adipokine that functions as a regulator of cancer stem cell-like
properties in human breast cancer
Yohei Shimono1, Hideaki Goto2 , Yohei Funakoshi2 , Yoshinori Imamura 2 ,Masanori Toyoda 2 , Naomi Kiyota 2 , Seishi Kono3 , Shintaro Takao3 ,Toru Mukohara4 , Hironobu Minami2(1Duke university, 2Hiroshima-Nishi Medical Center, 3Vitrisa Therapeutics, Inc.,
4
Gilead Sciences, Inc., 5LabCorp, Research Triangle Park)

O-36 Age-related alteration in nitric oxide signaling attenuates arrival oftransplanted hematopoietic stem/progenitor cells to bone marrow
Takayuki Morikawa, Keiyo Takubo(Department of Stem Cell Biology, Research Institute, National Center for Global
Health and Medicine)

17:10～17:20

Closing Remarks

Next Organizer Yukiko Gotoh(Graduate School of Pharmaceutical Sciences, The University of Tokyo)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-35 Acute lymphoblastic leukemia cells hijack a neuronal pathfinding mechanism
to invade the central nervous system
Hisayuki Yao1,2 , Trevor Price1, Matthew Warner1,3 , Gaia Cantelli1,
Lindsey Olivere1, Brandon Ngo1, Sarah Ridge1, Joe Therrien4 ,Stacey Tannheimer4 , Chad McCall1, Anjen Chenn5, Dorothy Sipkins1

Program / Poster(1Division of Molecular and Cellular Biology, Kobe University Graduate School of
Medicine, 2Division of Medical Oncology/Hematology, Kobe University Graduate
School of Medicine, 3Division of Breast and Endocrine Surgery, Kobe University
Graduate School of Medicine, 4Division of Breast and Medical Oncology, National
Cancer Center Hospital East)

Program / 1st Day Program / 2nd Day

O-33 Epigenetic hallmarks of aging hematopoietic stem cells
Motohiko Oshima, Kazumasa Aoyama, Yaeko Nakajima-Takagi,
Naoki Itokawa, Wakako Kuribayashi, Shuhei Koide, Atsushi Iwama

Abstract / Poster

9

16th Stem Cell Research SymposiumAbstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

June 1 (Fri.)–June 2 (Sat.), 2018

Poster Session
P-01 Identification of a novel marker that defines bona fide and complementresistant HSC fractions
Takashi Jiromaru(Medicine and Biosystemic Science, Kyushu University)

P-02 G0 phase analysis of hematopoietic stem cell in mVenus-p27K- mice
Tsuyoshi Fukushima1, Yosuke Tanaka1, Toshihiko Oki2 , Toshio Kitamura1(1Institute of medical medicine, 2Harvard university)

P-03 Ca 2+ -Mitochondrial axis drives cell division in hematopoietic stem cells
Terumasa Umemoto1, Michihiro Hashimoto1, Takayoshi Matsumura 2 ,Toshio Suda1,2(1International Research Center for Medical Sciences, Kumamoto University,
2
Cancer Science Institute of Singapore, National University of Singapore)

P-04 CGRP-CRLR/RAMP1 signal is essential in stress-induced hematopoiesis
Akira Suekane1, Yusuke Saito1, Tomonaga Ichikawa1, Nakahata Shingo1,
Honami Ogoh1, Kazutake Tsujikawa 2 , Kazuhiro Morishita1(1Division of Tumor and Cellular Biochemistry, Department of Medical Science,
Faculty of Medicine, University of Miyazaki, Miyazaki, Japan, 2Laboratory of
Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences,
Osaka University, Osaka, Japan)

P-05 Foxp2 is necessary for maintenance of quiescence in hematopoietic stem cells
Saki Morimoto(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)

P-06 Expression of TET family members on intra-aortic hematopoietic cell clustersof the dorsal aorta in midgestation mouse embryo
Ikuo Nobuhisa, Kiyoka Saito, Tetsuya Taga
(Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU))

P-07 Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal
expansion during pregnancy and regeneration
Ryo Ichijo1, Hiroki Kobayashi1, Yoneda Saori1, Yui Iizuka1, Hirokazu Kubo1,
Shigeru Matsumura1, Tetsuya Honda 2 , Fumiko Toyoshima1(1Institute for Frontier Life and Medical Science, Kyoto University, 2Department of
Dermatology, Kyoto University Graduate School of Medicine)P-08 Basic properties of the mammary stem cell system of rats: towards
mathematical modeling of its response to ionizing radiation
Tatsuhiko Imaoka1, Ken-ichi Kudo1, Yukiko Nishimura1, Daisuke Iizuka1,
Yuya Hattori2,3 , Ritsuko Watanabe3 , Akinari Yokoya3 , Shizuko Kakinuma1(1QST National Institute of Radiological Sciences, 2Tokyo Institute of Technology,
3
QST Quantum Beam Science Research Directorate)

P-09 Evaluation of low-dose radiation effect on mammary stem cells using threedimensional immunnohistochemical analysis
Daisuke Iizuka, Tatsuhiko Imaoka, Yukiko Nishimura, Shizuko Kakinuma(Department of Radiation Effects Research, National Institute of Radiological
Sciences, QST)

16th Stem Cell Research Symposium

10June 1 (Fri.)–June 2 (Sat.), 2018

(1Division of Tumor and Cellular Biochemistry Department of Medical, Faculty of
Medicine, University of Miyazaki, 2Department of Biological, Graduate School of
Humanities and Science, Nara Women’s University, 3Division of Hematological
Malignancy, National Cancer Center Research Institute, 4Department of Biological,
Graduate School of Humanities and Science, Nara Women’s University,
5
Department of Oral immunology and Infectious Disease, University of Louisville,
School of Dentistry, 6Division of Tumor and Cellular Biochemistry Department ofMedical, Faculty of Medicine, University of Miyazaki, 7Laboratory ofDevelopmental Neurobiology, Graduate School of Brain Science, Doshisha
University)(1Department of Stem Cell Biology and Medicine, Graduate School of Medical
Science, Kyushu University, 2Laboratory of Biochemistry and Molecular Biology,
Department of Medical Sciences, University of Miyazaki)

P-12 The role of DNA repair machinery and cell death in induced pluripotent stem
cells
Mikio Shimada, Yoshihisa Matsumoto

P-13 Phenotypic differences associated with the loss of Mbd3 between ESCs and
EpiSCsMasataka Hirasaki, Masamitsu Asaka, Kousuke Uranishi, Ayumu Suzuki,
Masazumi Nishimoto, Akihiko Okuda(Division of Developmental Biology, Research Center for Genomic Medicine,
Saitama Medical University)

P-14 Generation of keratinocytes from human induced pluripotent stem cells andanalysis of its DNA damage response
Tomoko Miyake1,2 , Mikio Shimada3 , Yoshihisa Matsumoto3 ,Akitoshi Okino1(1FIRST, Institute of Innovative Research, Tokyo Institute of Technology,
2
Cosmetic R&D Department, Takara Belmont Corp., 3LANE, Institute of
Innovative Research, Tokyo Institute of Technology)

P-15 Neural dysfunction of Tay-Sachs disease (TSD) neurons established frominduced pluripotent stem cells derived from TSD patients
Kozo Matsushita(Department of Cell Modulation, Institute of Molecular Embryology and Genetics,
Kumamoto University)(Yamaguchi University, Veterinary Anatomy)

P-17 Analysis of the microenvironment for the maintenance of primordial follicle
Go Nagamatsu, Katsuhiko Hayashi(Kyushu University Department of Stem Cell Biology and Medicine Graduate
School of Medical Science)11

16th Stem Cell Research Symposium

Abstract / Poster

P-16 Reprograming of domestic and wild animal fibroblast by cell fusion withmouse embryonic stem cells
Hiroyuki Imai, Yasuo Kiso, Takeshi Kusakabe, Kiyoshi Kano

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

(Laboratory for Advanced Nuclear Research, Institute of Innovative Research,
Tokyo Institute of Technology)

Program / Poster

P-11 The hemi-methylated DNA recognition factor, Np95 maintains adulthippocampal neurogenesis
Shuzo Matsubara1, Naoya Murao2 , Taito Matsuda1, Kinichi Nakashima1

Program / 1st Day Program / 2nd Day

P-10 Af10 regulates spatiotemporal cell proliferation of neural progenitor andneural crest cells in mid facial development via H3K79 methylation
Honami Ogoh1,2 , Kazutsune Yamagata3 , Tomomi Nakao4 , Lisa L. Sandell5,
Kazuhiro Morishita6 , Issay Kitabayashi3 , Toshio Watanabe4 , Daisuke Sakai7

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

June 1 (Fri.)–June 2 (Sat.), 2018

P-18 AKT promotes somatic cell nuclear reprogramming through α-KG
Yoichi Sekita1, Akari Matsumoto1, Yuki Kawasaki2 , Yuki Sugiura3 ,Ryo Konno4 , Yoshio Kodera4 , Takashi Kohda 2 , Fumitoshi Ishino2 ,Tohru Kimura1(1Lab Stem Cell Biol, Kitasato University School of Science, 2Medical ResearchInstitute, Tokyo Medical and Dental University, 3Keio University School of
Medicine, 4Lab Biophysics, Kitasato University School of Science)

P-19 Mutant ASXL1 provokes mitochondrial dysregulation and ROS-induced DNA
damage in haematopoietic stem and progenitor cells
Takeshi Fujino, Susumu Goyama, Toshio Kitamura(Division of Cellular Therapy, The Institute of Medical Science, The University ofTokyo)

P-20 Loss of Tet2 and Tet3 alleles accentuate development of myeloid and lymphoidmalignancies
Raksha Shrestha1, Koichiro Maie1, Mamiko Sakata-Yanagimoto1,2 ,Motohiko Oshima3 , Yaeko Nakajima-Takagi3 , Hirotaka Matsui4 ,Takayasu Kato1,2 , Hideharu Muto1,2 , Enguerran Mouly5,
Olivier A. Bernard5, Haruhiko Koseki6 , Atsushi Iwama3 , Shigeru Chiba1,2(1Graduate School of Comprehensive Human Sciences, University of Tsukuba,
Tsukuba, Japan, 2Faculty of Medicine, University of Tsukuba, Tsukuba, Japan,
3
Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University, Chiba, Japan, 4Department of Molecular Laboratory Medicine,
Kumamoto University, Kumamoto, Japan, 5INSERM U1170, Institut Gustave
Roussy, Villejuif, France, 6RIKEN Research Center for Allergy and Immunology,
Yokohama, Japan)

P-21 Identification of a subpopulation of glioma cells with a potential for tumor
niche development involving myeloid cells
Kouichi Tabu, Tetsuya Taga

(Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU))

P-22 The novel imipridone ONC212 induces pronounced GPR132-mediated antileukemia effects and is highly synergistic with Bcl-2 inhibitor ABT-199
Takenobu Nii1, Jo Ishizawa1, Varun Prabhu2 , Vivian Ruvolo1,
Neel Madhukar3 , Ran Zhao1, Hong Mu1, Lauren Heese1, Kensuke Kojima4 ,Mathew Garnett 5, Ultan McDermott 5, Cyril Benes6 , Neil Charter7,
Sean Deacon7, Olivier Elemento3 , Joshua Allen2 , Wolfgang Oster2 ,Martin Stogniew2 , Michael Andreeff1(1Section of Molecular Hematology and Therapy, Department of Leukemia, The
University of Texas MD Anderson Cancer Center, Houston, TX, 2Oncoceutics,
Inc., Philadelphia, PA, 3Weill Cornell Medicine, New York, NY, 4 Saga University,
Saga, Japan, 5Wellcome Trust Sanger Institute, Hinxton, UK, 6Massachusetts
General Hospital, Boston, MA, 7DiscoverX Corporation, Fremont, CA)

P-23 Characterization of Chronic Myeloid Leukemia Initiating Cells Using a Novel
G 0 Marker
Yosuke Tanaka, Keiko Mikami, Tsuyoshi Fukushima, Susumu Goyama,
Toshio Kitamura(University of Tokyo, Institute for Medical Science)

16th Stem Cell Research Symposium

12June 1 (Fri.)–June 2 (Sat.), 2018

(1Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University, 2International Research Center for Medical Sciences, Kumamoto
University)

P-25 The role of one-carbon metabolic enzyme MTHFD1L for cancer stem-like cells
in triple-negative breast cancer
Tatsunori Nishimura1, Mengjiao Li2 , Kazuki Nishimura1, Shigeki Sato1,
Noriko Gotoh1(1Kanawazwa University Cancer Research Institute, 2Fudan University Shanghai
Cancer Center)(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)(1Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University, 2Laboratory of Stem Cell Therapy, Center for Experimental
Medicine, The institute of Medical Science, The University of Tokyo)

P-28 Impairment of bone marrow erythropoiesis is induced by disruption of Notch
signaling in specific bone marrow microenvironment
Tatsuhiro Sakamoto1,2 , Naoshi Obara1, Hidekazu Nishikii1, Takayasu Kato1,
Ryosuke Fujimura3 , Luan Cao Sy4 , Mamiko Sakata-Yanagimoto1,
Satoru Takahashi5, Shigeru Chiba1(1Department of Hematology, Faculty of Medicine, University of Tsukuba,
2
Department of Hematology, University of Tsukuba Hospital, 3School of Medical
Sciences, University of Tsukuba, 4Graduate School of Comprehensive Human
Sciences, University of Tsukuba, 5Department of Anatomy and Embryology,
Faculty of Medicine, University of Tsukuba)

P-29 Hierarchical differentiation of mesenchymal progenitors forming
hematopoietic stem cell niches
Yasufumi Uehara1, Kentaro Hosokawa 2 , Yuya Kunisaki3 , Fumio Arai2(1Department of Medicine and Biosystemic Science, Kyushu University,2
Department of Stem Cell Biology and Medicine, Kyushu University, 3Center forcellular and Molecular Medicine, Kyushu University Hospital)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-27 The polycomb protein Bmi1 restrains perivascular mesenchymal stromal cells
from adipogenic differentiation to maintain the integrity of hematopoietic
stem cell niche
Yuko Kato1, Li-Bo Hou1, Shuhei Koide1, Satoru Miyagi1, Motohiko Oshima1,
Kazumasa Aoyama1, Sha Si1, Satoshi Yamazaki2 , Erico Nitta1,
Atsushi Iwama1

Program / Poster

P-26 Roles of angiopoietin-1 in reconstruction of vascular niches by leukemia
Haruka Imanishi

Program / 1st Day Program / 2nd Day

P-24 The core targets of polycomb repressive complex 2 in the maintenance of
myelodysplastic syndrome stem cells
Kazumasa Aoyama1, Motohiko Oshima1, Makiko Mochizuki-Kashio1,
Shuhei Koide1, Emi Suzuki1, Yuko Kato1, Yaeko Nakajima-Takagi1,
Nobuhiro Hiura1, Goro Sashida1,2 , Atsushi Iwama1

Abstract / Poster

13

16th Stem Cell Research SymposiumP-30 Abcg2-induced MDS/AML cells inhibited hematopoiesis through blocking
osteoblastic differentiation of bone marrow mesenchymal stem cells
Yasutaka Hayashi1, Kimihito C Kawabata 2 , Yasufumi Uehara3 ,Yosuke Tanaka1, Shigeru Kiryu4 , Yasunori Ota5, Yuya Kunisaki3 ,Tomofusa Fukuyama1, Susumu Goyama1, Fumio Arai3 , Toshio Kitamura1(1Division of Cellular Therapy, The Institute of Medical Science, The University ofTokyo, 2Division of Hematology/Medical Oncology, Department of Medicine,
Weill-Cornell Medical College, Cornell University, 3Department of Stem Cell
Biology and Medicine/Cancer Stem Cell Research, Graduate School of Medical
Sciences, Kyushu University, 4Department of Radiology, The Institute of Medical
Science, The University of Tokyo, 5Department of Pathology, Research Hospital,
The Institute of Medical Science, The University of Tokyo)

P-31 Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce
Glioma Stem Cell Niches at the Tumor Border
Takuichiro Hide1, Yoshihiro Komohara 2 , Yuko Miyasato2 ,Hideo Nakamura1, Keishi Makino1, Motohiro Takeya 2 , Jun-ichi Kuratsu1,
Akitake Mukasa1, Shigetoshi Yano1(1Department of Neurosurgery, Kumamoto University Medical School,2
Department of Cell Pathology, Kumamoto University Medical School)

P-32 Analysis of the effects of choroid plexus on adult neurogenesis by focusing ona chronic inflammatory regulator, Angiopoietin-like protein 2
Rie Yamashita, Kinichi Nakashima, Sayako Katada(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)

P-33 Maintenance of breast cancer stem-like cells by cancer associated fibroblastderived soluble factors
Takahiko Murayama1, Tatsunori Nishimura 2 , Masao Yano3 ,Kei-ichiro Tada4 , Kazuhiro Ikeda5, Koji Okamoto6 , Kuniko Horie-Inoue5,
Satoshi Inoue5, Arinobu Tojo1, Noriko Gotoh2(1Division of Molecular Therapy, Institute of Medical Science, The University ofTokyo, 2Division of Cancer Cell Biology, Cancer Research Institute of Kanazawa
University, Kanazawa University, 3Department of Breast Surgery, Minamimachida
Hospital, 4Department of Breast & Endocrine Surgery, Graduate School of
Medicine, University of Tokyo, 5Division of Gene Regulation and Signal
Transduction, Research Center for Genomic Medicine, Saitama Medical University,
6
Division of Cancer Differentiation, National Cancer Center Research Institute)P-34 Hematopoietic stem cells from human pluripotent stem cells
Ryohichi Sugimura(Stem Cell Transplantation Program, Division of Pediatric Hematology andOncology, Dana-Farber Cancer Institute, Boston Children’s Hospital andDana-Farber Cancer Institute)

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

June 1 (Fri.)–June 2 (Sat.), 2018

16th Stem Cell Research Symposium

14