The 11th Stem Cell Research Symposium
Friday, May 17.

Program

The First Day

Registration・Exhibit posters

9：00～

Opening Remarks Organizer Shigeru Chiba

9：30～9：40(Department of Hematology, Faculty of Medicine, University of Tsukuba)

Session 1 : Hematopoietic Stem Cell
Chair

9：40～10：40

Mineo Kurokawa(Department of Hematology & Oncology Graduate School of Medicine,
The University of Tokyo)

O-1

Hemp, an epigenetic regulator, sustains hematopoietic stem cell quiescencethrough regulating FoxO3a and downstream CDK inhibitors
Hiroaki Honda1, Keiyo Takubo2, Takeshi Ueda1, Norimasa Yamasaki1,
Ayako Nakamura-Ishizu2, Zen-ichiro Honda3, Fumio Arai2, Toshio
Suda2(1Research Institute of Radiation Biology and Medicine, Hiroshima
University, 2The Sakaguchi Laboratory of Developmental Biology,
Keio University School of Medicine, 3Institute of Environmental
Science for Human Life, Ochanomizu University)

O-2

Visualization and functional analysis of Geminin, a candidate molecule governing
self-renewal and cellular differentiation of hematopoietic stem cells
Shin’ichiro Yasunaga1, Yoshinori Ohno1, Toshiaki Kurogi1, Keita
Saeki1, Yoshie Nakashima1, Motoaki Ohtsubo2, Yoshihiro Takihara1(1Dept. Stem Cell Biol., RIRBM, Hiroshima Univ., 2Dept. Food andFerment. Sci., Beppu Univ.)

O-3

Aspp1 (Apoptosis-stimulating protein of p53, 1) induces hematopoietic stem cell
cycling and apoptosis in response to cellular stress
Masayuki Yamashita, Eriko Nitta, Toshio Suda
(Department of Cell Differentiation, the Sakaguchi Laboratory ofDevelopmental Biology, Keio University School of Medicine)

Coffee Break

10：40～11：00

Special Lecture 1

11：00～11：30

Chair Toshio Suda
(Keio University School of Medicine)

S-1 Replication stress in aging hematopoietic stem cells
Emmanuelle Passegue,PhD(The Eli and Edythe Broad Center of Regeneration Medicine andStem Cell Research,University of California San Francisco)

Lunch Time

11：30～13：10

Poster Session

13：10～14：10

Coffee Break

14：10～14：30

Session 2 : Hematopoietic Stem Cell Regulation

14：30～15：35

Chair Koichi Akashi(Dept.of Medicine and Biosystemic Science Faculty of Medicine,
Kyushu University)

Topics in Human HSCs
Transcriptional architecture of the human hematopoietic hierarchy:
insights into lineage commitment and self-renewal
Elisa Laurenti, Ph.D.
(Campbell Family Institute for Cancer Research,
Ontario Cancer Institute,University Health Network)
O-4

Adiponectin promotes proliferation of hematopoietic cells in vivo.
Yosuke Masamoto1, Shunya Arai1, Tomohiko Sato1, Akihide Yoshimi1,
Iseki Takamoto2, Naoto Kubota2, Takashi Kadowaki2, Mineo
Kurokawa1(1Department of Hematology and Oncology, the University of Tokyo,
2Department of Metabolic Diseases, the University of Tokyo)

O-5

Functional Significance of MPL Expression in the Human Primitive Hematopoietic
Stem Cell Compartment
Masaya Takahashi, Yoshikazu Matsuoka, Ryusuke Nakatsuka, Ryuji
Iwaki, Hirao Kohno, Tatsuya Fujioka, Yutaka Sasaki, Yoshiaki
Sonoda(Department of Stem Cell Biology and Regenerative Medicine,
Graduate School of Medical Science, Kansai Medical University)

Coffee Break

15：35～15：50

Session 3 : iPS/ES Cell (1)15：50～16：50

Chair Takumi Era(Department of Cell Modulation ,IMEG, Kumamoto University)
O-6

Incompletely Reprogrammed Human iPSCs Form Glioma-like Tumors ThroughGenomic Instability During Neural Differentiation
Yohei Okada1, Fuyuki Miya2, Masato Koike3, Shuta Tomisato1,
Tomoko Tokura1, Yasuharu Ishihara1, Daisuke Shimojo1, Chinatsu
Hattori1, Daisuke Kanematsu4, Yonehiro Kanemura4, Kazuhisa
Kohda1, Gen Sobue5, Shinya Yamanaka6, Michisuke Yuzaki1, Yasuo
Uchiyama3, Eiji Ikeda7, Tatsuhiko Tsunoda2, Hideyuki Okano1(1Department of Physiology, School of Medicine, Keio University,
2Laboratory for Medical Informatics, Center for Genomic Medicine,
RIKEN, 3Department of Cell Biology and Neuroscience, Graduate
School of Medicine, Juntendo University, 4Division of Regenerative
Medicine, Institute for Clinical Research, Osaka National Hospital,
National Hospital Organization, 5Department of Neurology, Graduate
School of Medicine, Nagoya University, 6Center for iPS Cell Researchand Application (CiRA), Kyoto University, 7Department of Pathology,
Graduate School of Medicine, Yamaguchi University)

O-7

Characterization of dysgerminoma like tumors arisen in the process of generating
common marmoset induced pluripotent stem cells
Saori Yamaguchi1, Tomotosh Marumoto1, Takenobu Nii1, Hirotaka
Kawano1, Liao Jiyuan1, Yoko Nagai1, Michiyo Okada1, Atsushi
Takahashi1, Hiroyuki Inoue1, Erika Sasaki2, Shinji Okano3, Yoshie
Miura1, Kenzaburo Tani1(1Division of Molecular and Clinical Genetics, Medical Institute of
Bioregulation, Kyushu University, 2Central Institute forExperimental Animals, Keio University, 3Division of
Pathophysiological and Experimental Pathology, Department of
Pathology, Kyushu University)

O-8

Molecular functions of the LIM-homeobox transcription factor Lhx2 inhematopoietic stem-like cell differentiation from mouse embryonic stem cells
Kenji Kitajima1, Manami Kawaguchi1, Michelina Iacovino2, Michael
Kyba2, Takahiko Hara1(1Stem Cell Project, Tokyo Metropolitan Institute of Medical Science,
2Lillehei Heart Institute and Department of Pediatrics, University of
Minnesota)

Coffee Break

16：50～17：05

Session 4 : Mesenchymal and Tissue Stem Cell

17：05～18：05

Chair Noriko Gotoh(Division of Cancer Cell Biology, Cancer Molecular Target Exploration Program
Cancer Research Institute, Kanazawa University)

Keynote Lecture on Mesenchymal Stem Cell
Genetically modified stem cell therapy for neurological diseases
Haeyoung Suh-Kim1,2 and Sung-Soo Kim3
(1Department of Anatomy, 2NeuroScience Graduate Program, 3Centerfor Cell Death Regulating Biodrug, Ajou University, School of
Medicine)
O-9

The fate switch of hair follicle stem cells to the epidermis underlies hair follicle
aging and baldness
Yasuaki Mohri1, Nguyen Thanh Binh1,2, Hiroyuki Matsumura1, Yuko
Tadokoro2,3, Mayumi Ito4, Jan Hoeijmakers5, Emi Nishimura1,2(1Department of Stem Cell Biology, Medical Research Institute, Tokyo
Medical and Dental University, 2Department of Stem Cell Medicine,
Cancer Research Institute, Kanazawa University, 3Division of
Molecular Genetics, Cancer Research Institute, Kanazawa University,
4Departments of Dermatology and Cell Biology, New York University
School of Medicine, 5Department of Genetics, Cancer Genomics
Center)O-10 Lactic acid bacteria convert human fibroblasts to multipotential cells
Kunimasa Ohta, Rie Kawano, Naofumi Ito(Kumamoto University)

General Meeting

Chief Director

Toshio Suda

18:05～18:15(Department of Cell Differentiation, Keio University School of Medicine)

Reception(Venue for Poster Presentation)

18:15～20:00

Saturday, May 18.

The Second Day

Session 5 : iPS/ES Cell (2)Chair

9：20～10：20

Hideyuki Okano(Dept. of Physiology, Keio University School of Medicine)

Keynote Lecture on iPS cells
Differentiation and signaling pathways in human pluripotent
stem cells
Yong-Mahn Han, Ph.D.
(Department of Biological Sciences and Center for Stem Cell
Differentiation, KAIST)
O-11 Demonstration of iPSCs as a disease model for the preclinical assessment of safeand efficacious vector mediated CGD gene therapy
Huan-Ting Lin, Makoto Otsu, Hiromitsu Nakauchi(Division of Stem Cell Therapy, Center for Stem Cell Biology andRegenerative Medicine, IMSUT.)
O-12 Analysis of iPS cells derived from Fibrodysplasia ossificans progressiva.
Makoto Hamasaki1, Yoshinobu Hashizume2, Yoshinori Yamada1,
Tomohiko Katayama1, Hirohiko Hohjoh3, Noemi Fusaki4, Yasuharu
Nakashima5, Hirokazu Furuya6, Nobuhiko Haga7, Yoichiro Takami1,
Takumi Era1
(1Department of Cell Modulation, Institute of Molecular Embryology
and Genetics,Kumamoto University, 2RIKEN Program for Drug
Discovery and Medical Technology Platforms. 3National Institute of
Neuroscience, National Center of Neurology and Psychiatry, 4JST
PRESTO and Ophthalmology, Keio University, 5Department ofOrthopaedic Surgery, Kyushu University School of Medicine,
6Department of Neurology, Neuro-Muscular Center, National Omuta
Hospital, 7Rehabilitation Medicine, Graduate School of Medicine.)

Coffee Break

10：20～10：40

Special Lectures on HSC Microenvironmental Regulation 10：40～11：30
Chair

Shigeru Chiba(Department of Hematology, Faculty of Medicine, University of Tsukuba)

S-2

Oncogenesis in the hematopoietic system: A role for the niche ?
Marc H.G.P. Raaijmakers, M.D., Ph.D.
(Erasmus University Medical Center, Department of Hematology andErasmus Stem Cell Institute)

S-3

Microenvironmental Regulation of Normal and Malignant
Hematopoietic Stem Cells
Il-Hoan Oh, MD, Ph.D
(Catholic High-Performance Cell Therapy Center, The Catholic
University of Korea)

Lunch Time

11：30～13：10

Poster Session

13：10～14：10

Coffee Break

14：10～14：30

Session 6 : Epigeneticsi in Leukemogenesis

14：30～15：30

Chair

Yoshihiro Takihara(Department of Stem Cell Biology, Research Institute for Radiation Biology andMedicine, Hiroshima University)

O-13 A novel approach to identify mutations responsible for leukemogenesis based on
epigenetic information
Jun Odawara1,2, Kohta Miyawaki1, Junichiro Yuda1, Masayasu
Hayashi1,2, Kazumitsu Maehara2, Kentaro Kohno1, Takahiro Shima1,
Masao Nagasaki3, Yasuyuki Ohkawa2, Koichi Akashi1(1Department of Medicine and Biosystemic Sciences, Kyushu
University Graduate School of Medicine, 2Department of Advanced
Medical Initiatives, Faculty of Medical Sciences, Kyushu University,
3Division of Biomedical Information Analysis, Department ofIntegrative Genomics, Tohoku Medical Megabank Organization,
Tohoku University)
O-14 Reduced Tet2 Function Contributes to Dysregulated Hematopoietic Stem Cells andSubsequent Development of Peripheral T- cell Lymphoma
Hideharu Muto1, Mamiko Sakata-Yanagimoto1, Yasuyuki Miyake1,
Terukazu Enami1, Yuhei Kamada1, Kazumi Suzukawa1, Naoya
Nakamura2, Genta Nagae3, Hiroyuki Aburatani3, Seishi Ogawa4,
Shigeru Chiba1(1Department of Hematology, Faculty of Medicine, University ofTsukuba, 2Department of Pathology, Tokai University School of
Medicine, 3Genome Science Division RCAST- The University of Tokyo,
4Cancer Genomics Project, Graduate School of Medicine, The
University of Tokyo)
O-15 C-terminal-truncating ASXL1 mutations induce MDS via derepression of miR125aand reduced expression of Clec5a/Mdl1
Daichi Inoue, Toshio Kitamura(Division of Cellular Therapy, Advanced Clinical Research Center, The
Institute of Medical Science, The University of Tokyo)

Coffee Break

15：30～15：50

Session 7 : Cancer Stem Cell

15：50～16：50

Chair

Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University)

O-16 Leukemogenic function of TIM-3, a leukemia stem cell marker, in acute
myelogenous leukemia and myelodysplastic syndromes
Yoshikane Kikushige, Takahiro Shima, Junichiro Yuda, Toshihiro
Miyamoto, Koichi Akashi(Department of Medicine and Biosystemic Sciences, Kyushu
University)O-17 Immunological regulation of leukemia-initiating cells in MLL-rearranged leukemia
Naoki Hosen, Jun Nakata, Kana Hasegawa, Hiroko Kinoshita,
Katsuhiko Nakano, Yoshihiro Oka, Atsushi Kumanogoh, Haruo
Sugiyama(Osaka University Graduate School of Medicine)
O-18 Innovative microRNA-Based Cellular Reprogramming Medicine for Exterminationof Cancer Stem Cells
Masamitsu Konno1, Hisataka Ogawa2,3, Tsuyoshi Yamamoto4,
Yuichiro Doki5, Nobuhiro Nishiyama6,7, Kazunori Kataoka8, Satoshi
Obika4, Masaki Mori5, Hideshi Ishii1(1Department of Frontier Science for Cancer and Chemotherapy,
Osaka University, Graduate School of Medicine, 2Department ofFrontier Science for Cancer and Chemotherapy, 3Department of
Gastroenterological Surgery, Osaka University, Graduate School of
Medicine, 4Bioorganic Chemistry, Graduate School and School of
Pharmaceutical Sciences, Osaka University, 5Department of
Gastroenterological Surgery, Osaka University, Graduate School of
Medicine, 6Department of Materials Engineering, University of Tokyo,
7Department of Chemical Resources Laboratory, Tokyo Institute ofTechnology, 8Department of Materials Engineering, University ofTokyo)

Coffee Break

16：50～17：05

Session 8 : iPS/HSC
Chair Atsushi Hirao

17：05～18：05(Kanazawa University,Cancer Research Institute)
O-19 Analysis of familial platelet disorder with disease-specific iPSCs.
Hitomitsu Iizuka, Shunya Arai, Masashi Miyauchi, Kazuki Taoka,
Keisuke Kataoka, Masataka Hosoi, Keiki Kumano, Mineo Kurokawa(Department of Hematology and Oncology, the University of Tokyo)
O-20 A telomere shelterin factor, POT1 supports the maintence of hematopoietic stem
cells.
Kentaro Hosokawa, Fumio Arai, Yumiko Gomei, Toshio Suda
(Department of Cell Differentiation, The Sakaguchi Laboratory ofDevelopmental Biology, School of Medicine, Keio University)
O-21 The Role of Long Intergenic Non-Coding RNAs in Hematopoietic Stem Cells
George Wendt, Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of
Medicine, Chiba University)

Closing Remarks
Next Organizer

18：05～18：15
Yoshihiro Takihara(Department of Stem Cell Biology, Research Institute for Radiation Biology andMedicine, Hiroshima University)

Poster Session
Friday, May 17

13：10～14：10

P-01 Sox17 protein-mediated maintenance of cells with stem cell phenotype in thehematopoietic cell clusters in the fetal AGM region
Ikuo Nobuhisa1, Mitsujiro Osawa2, Mami Uemura3,4, Yoko Kishikawa5,
Maha Anani1, Kaho Harada1, Haruna Takagi2, Masami
Kanai-Azuma4, Yoshiakira Kanai3, Atsushi Iwama2, Tetsuya Taga1(1Dept. Stem Cell Reg., Med. Res. Inst., Tokyo Med. Dental Univ.,
2Dept. Cellular and Mol. Med., Grad. Sch. Med., Chiba Univ., 3Dept.
Vet. Ana., Grad. Sch. Agri. and Life Sci., Univ. of Tokyo, 4Dept. Exp
Ani. Mod. for Hum. Dis., Cent. For Exp. Animal., Tokyo Med. Dent.
Univ., 5Dept. Cell Fate Mod., IMEG, Kumamoto Univ.)
P-02 The Role of Eset in Hematopoietic Stem Cell
Shuhei Koide1, Satoru Miyagi1, George Wendt1, Motohiko Oshima2,
Atsushi Iwama1(1Department of Cellular and Molecular Medicine, Graduate School of
Medicine, Chiba University, 2Department of Cellular and Molecular
Medicine, Graduate School of Medicine, Chiba University / JST,
CREST)
P-03 TPO/cMpl-dependent differentiation pathway for megakaryocytes at the proximityof hematopoietic stem cells.
Hidekazu Nishikii, Kenji Matsuhita, Yosuke Kanazawa, Terumasa
Umemoto, Yu Matsuzaki, Takayasu Kato, Mamiko
Sakata-Yanagimoto, Masayuki Yamato and Shigeru Chiba.
(Department of Hematology, Faculty of Medicine, Graduate School ofComprehensive Human Sciences, University of Tsukuba)
P-04 Differentiation of mast cells from induced pluripotent stem cells
Tomoko Yamaguchi1, Katsuhisa Tashiro1, Satoshi Tanaka2, Hiroyuki
Mizuguchi3, Kenji Kawabata1(1National Institute of Biomedical Innovation, 2Okayama University
Graduate School, 3Osaka University)
P-05 Development of a highly efficient method for isolating bone-derived small stem
cells identified in adult mouse bone
Ryusuke Nakatsuka, Ryuji Iwaki, Yoshikazu Matsuoka, Masaya
Takahashi, Tatsuya Fujioka, Yutaka Sasaki, Yoshiaki Sonoda(Department of Stem Cell Biology and Regenerative Medicine,
Graduate School of Medical Science, Kansai Medical University)
P-06 Functional Restoration of Aged Stem Cells by Regulating Their Competence
Hayato Naka-Kaneda1, Michiko Ohno-Oishi1, Yo Mabuchi2, Shiho
Nakamura1(1RIKEN, 2Tokyo Medical and Dental University)
P-07 LNGFR+Thy-1+CD106high+ cells reveal functionally distinct subpopulations inmesenchymal stem cells
Yo Mabuchi1,2, Chihiro Akazawa1, Hideyuki Okano2, Yumi Matsuzaki2(1Department of Biochemistry and Biophysics, Graduate School of
Health Care Sciences, Tokyo Medical and Dental University,
2Department of Physiology, Keio University School of Medicine)P-08 Igf2 accelerates mesenchymal cell activity in the mouse yolk sac
Tomoko Inoue1,2, Chiyo Mizuochi1, Kasem Kulkeaw1, Keai Sinn Tan1,
Sarinthip Preedagasamzin1, Yuka Tanaka1, Daisuke Sugiyama1(1Center for Clinical and Translational Research Kyushu University
Hospital, 2Department of Medicine and Biosystemic Science, Kyushu
University, Graduate School of Medical Sciences)
P-09 Inhibition of VEGF-C induces the expression of FLT 3 in IL-1-beta-stimulated
adult human dermal fibroblasts
Takuji Matsuo, Ryosuke Shirasaki, Yoko Oka, Naoki Shirafuji(Teikyo University School of Medicine)P-10 A novel 3D imaging technique reveals dynamic behavior of the biliary tree andliver progenitor cells in regenerating mouse livers
Tohru Itoh, Kota Kaneko, Atsushi Miyajima(Institute of Molecular and Cellular Biosciences, The University ofTokyo)
P-11 Immunogenicity of induced pluripotent stem cells assessed in the setting of porcine
syngeneic transplantation
Yoshihisa Mizukami1, Tomoyuki Abe1, Hiroaki Shibata2, Shuh-hei
Fujishiro1, Shuji Hishikawa3, Eiji Kobayashi3, Yutaka Hanazono1,4(1Division of Regenerative Medicine, Jichi Medical University,
2Tsukuba Primate Research Center, National Institute of Biomedical
Innovation, 3CDAMTec, Jichi Medical University, 4 JST, CREST)
P-12 Fas signaling via 3-O-sulfated heparan sulfate is required for the differentiation ofmouse embryonic stem cells
Kazumi Hirano1, Norihiko Sasaki1, Toin van Kuppevelt2, Shoko
Nishihara1(1Faculty of Engineering, Soka University, 2Nijmegen Center for
Molecular Life Sciences, Radboud University Nijmegen Medical
Centre)P-13 Identification of The CXCL14 Receptor: CXCL14 is a Natural Inhibitor of The
CXCL12/CXCR4 Axis
Kosuke Tanegashima1, Kenji Suzuki1, Takashi Nagasawa2, Takahiko
Hara1(1Stem cell project group, Tokyo Metropolitan Institute of Medical
Science, 2Department of Immunobiology and Hematology, Institute of
Frontier Medical Sciences, Kyoto University)
P-14 Molecular Characterization of Human Germ Cell and A Trial toward In Vitro Germ
Cell Differentiation from Human iPSCs.
Ryusuke Nakajima, Masanori Imamura, Zachary Yu-Ching Lin, Rie
Yamadera, Yuji Takehara, and Hideyuki Okano(Department of Physiology, School of Medicine, Keio University)
P-15 Molecular characterization of proliferative germ-like cells and oocyte-like cells
derived from pluripotent stem cells in vitro
Masanori Imamura1, Mai Nitta2,3, Rieko Ikeda4, Keiichiro Yogo5,
Noritaka Fukunaga6, Eimei Sato6, Tatsuo Takeya2, Jun Miyoshi3,
Takashi Shinohara7, Yasuhisa Matsui6, Kuniya Abe4, Shinya
Yamanaka7, Toshiaki Noce1, and Hideyuki Okano1(1Department of Physiology, School of Medicine, Keio University;
2Nara Institute of Science and Technology; 3Osaka Medical Center for
Cancer and Cardiovascular Diseases; 4RIKEN BioResource Center;
5Shizuoka University; 6Tohoku University; 7Kyoto University)P-16 Molecular Characterization and Culture of Testicular Germ Cells in A New-World
Monkey Common Marmoset Callithrix Jacchus
Zachary YC Lin1, Masanori Imamura1, Takamasa Hirano2, Eiji
Matsunaga3, Miki Taoka3, Hiroo Imai4, Hirotaka James Okano1,
Atsushi Iriki3, Mikiko C Siomi5, Haruhiko Siomi2, Erika Sasaki6,
Hideyuki Okano1(1Physiology Department, Keio University, 2Molecular Biology
Department, Keio University, 3RIKEN BSI, 4Primate researchInstitute, Kyoto university, 5Biochemistry Department, Tokyo
university, 6CIEA)
P-17 Phylogenic diversity of DNA methylation status in mammalian germline
Orie Hikabe1, Masanori Imamura1, Ikuo Tomioka2, Zachary Yu-Ching
Lin1, Ryusuke Nakajima1, Arata Honda3, Ayako Isotani4, Masaru
Okabe4, Atsuo Ogura3, Erika Sasaki2, Hideyuki Okano1(1Dept. of Physiol., School of Med., 2Keio Univ., CIEA, 3Riken BRC,
4Genome Information Research Center, Osaka Univ.)
P-18 5-methylcytosine hydroxylase TET3 endows mid-gestational neural stem cells withthe astrogliogenic competence
Norihisa Bizen1, Tetsushi Kagawa1, Toshinobu Nakamura2, Toru
Nakano3, Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute,Tokyo Medical and Dental University, 2Department of Animal
Bio-Science, Nagahama Institute of Bio-Science and Technology,
3Department of Pathology, Graduate School of Medicine and Frontier
Biosciences, Osaka University)
P-19 Deficiency of DGCR8 gene, a candidate gene for 22q11.2 deletion-associatedschizophrenia, decreases cell proliferation and neurogenesis in the adult mousedentate gyrus
Yasuo Ouchi1, Yuya Banno1, Yuko Shimizu1, Shouta Ando1, Koichi
Adachi2, Takashi Iwamoto1(1Department of Biomedical Sciences, Chubu University,
2Radioisotope Research Center Medical Division, Nagoya University
Graduate School of Medicine)P-20 Notch3 null mutation in mice causes muscle hyperplasia by repetitive muscle
regeneration
Takeo Kitamoto, Kazunori Hanaoka(Kitasato University School of Science)
P-21 Anti-apoptotic molecule Anamorsin is crucial for stromal function to support
embryonic hematopoiesis
Akira Tanimura, Yuri Hamanaka, Hirohiko Shibayama, Yuzuru
Kanakura(Department of Hematology and Oncology, Osaka University
Graduate School of Medicine)Poster Session
Saturday, May 18

13：10～14：10

P-22 Analysis of endothelial niche cells in fetal spleen erythropoiesis
Keai Sinn Tan1, Tomoko Inoue2, Wai Feng Lim3, Chiyo Mizuochi4,
Kasem Kulkeaw4, Sarinthip Preedagasamzin4, Yuka Tanaka4, Mei I
Lai5, Daisuke Sugiyama4(1Center for Clinical and Translational Research Kyushu University
Hospital / Department of Pathology, Faculty of Medicine and Health
Sciences, Universiti Putra Malaysia, 2Center for Clinical andTranslational Research Kyushu University Hospital / Department ofMedicine and Biosytemic Science, Kyushu University, Graduate
School of Medical Sciences, 3Center for Clinical and Translational
Research Kyushu University Hospita, 4Center for Clinical andTranslational Research Kyushu University Hospital, 5Department of
Pathology, Faculty of Medicine and Health Sciences, Universiti Putra
Malaysia)
P-23 mTORC1 is essential for propagation of earliest T lineage-committed cell in normal
lymphopoiesis and leukemogenesis.
Takayuki Hoshii, Kasada Atsurou, Atsushi Hirao(Cancer Research Institute, Kanazawa University)
P-24 Generation and analysis of a novel model for chronic myelomonocytic leukemia(CMML) with acquired expression of c-CBL Q367P
Yuichiro Nakata1, Takeshi Ueda1, Norimasa Yamasaki1, Akiko
Nagamachi2, Keiyo Takubo3,Yasuhiro Ebihara4, Masashi Sanada5,
Seishi Ogawa5, Koichiro Tsuji4, Toshio Suda3, Toshiya Inaba2 andHiroaki Honda1(1Department of Disease Model, Research Institute for Radiation
Biology and Medicine,Hiroshima University, 2Department of
Molecular Oncology, Research Institute for Radiation Biology andMedicine,Hiroshima University, 3Departmentt of Cell Differentiation,
Keio University, 4Department of Pediatric Hematology/Oncology, The
Institute of Medical Science, TheUniversity of Tokyo, 5Cancer
Genomics Project, The University of Tokyo)
P-25 E2F-mediated transcriptional activation of the Geminin gene is under the
regulation of a negative-feedback loop
Yoshinori Ohno1, Keita Saeki1, Shin'ichiro Yasunaga1, Manabu Shirai2,
Toshiaki Kurogi1, Yoshie Nakashima1, Motoki Ohtsubo3, Yoshihiro
Takihara1(1Dept. Stem Cell Biol., RIRBM, Hiroshima Univ., 2Dept. Biosci.
Genetics., NCVC Res. Inst., 3Dept. Food and Fermentation Science.,
Beppu Univ.)
P-26Hes1 is responsible for Notch signaling-mediated suppression of acute myeloid
leukemia development
Takayasu Kato, Mamiko Sakata-Yanagimoto, Yasuyuki Miyake,
Hidekazu Nishikii, Hideharu Muto, Yasuhisa Yokoyama, Naoshi
Obara, Kazumi Suzukawa and Shigeru Chiba(Department Hematology, University of Tsukuba)
P-27 The roles of Hes1 in the myeloid leukemogenesis
Tomoyuki Uchida1, Jiro Kitaura1, Daichi Inoue1, Katsuhiro Togami1,
Kimihito Kawabata1, Toshihiko Oki1, Fumio Nakahara1, Akiko Sada2,
Yoshio Katayama2, Toshimitsu Matsui3, Yuka Harada4, Hironori
Harada4, Toshio Kitamura1

(1Division of Cellular Therapy, Advanced Clinical Research Center,
The Institute of Medical Science, The University of Tokyo,
2Department of Hematology, Kobe University, 3Department of
Hematology, Ono Municipal Hospital, 4Department of Hematology
and Oncology, Resarch Institute for Radiation Biology and Medicine,
Hiroshima University)
P-28 Constitutive NF-kB activation maintained by autocrine TNF-a signaling andactive proteasome system supports leukemia stem cell capacity
Yuki Kagoya, Akihide Yoshimi, Keisuke Kataoka, Masahiro
Nakagawa, Keiki Kumano, Shunya Arai, Mineo Kurokawa(Department of Hematology & Oncology, Graduate School of Medicine,
The University of Tokyo)
P-29 Integrin A6 as a special marker of refractory leukemia is important for
maintaining of leukemia stem cells.
Kazuko Kaneda, Kazuhiro Morishita(Division of Tumor and Cellular Biochemistry,Department of medical
Sciences,Faculty of Medicine, University of Miyazaki)
P-30 Novel Humanized Anti-CD33 Antibody with Enhanced Cytotoxic Functions for theTreatment of Acute Myeloid Leukemia
Takuya Murakami, Tomoaki Nakagawa, Tomonori Tawara, Tsuguo
Kubota, Uichi Nishiyama, Masao Asada, Miki Murai, Sayaka
Hori-Inada, Yukiko Shimizu, Yoshimasa Inagaki, Mitsuo Satoh,
Kenya Shitara, Tomoyuki Tahara, Rinpei Niwa
(Research Division, Kyowa Hakko Kirin Company, Limited)
P-31 Induced Pluripotent Stem Cell Reprogramming For Innovative Cell-Modifying
Technology in Cancer
Koichi Kawamoto1, Hideshi Ishii2, Masamitsu Konno2, Hisataka
Ogawa1.2, Hidetoshi Eguchi1, Masahiro Tanemura1.3, Hiroaki Nagano1,
Yuichiro Doki1, Masaki Mori1(1Department of Gastrointestinal Surgery, Osaka University
Graduate Schoolof Medicine, 2Department of Frontier Science forCancer and Chemotherapy, OsakaUniversity Graduate School of
Medicine, 3 Department of Surgery and Institute for Clinical Research,
NationalHospital Organization Kure Medical Center)
P-32 Identification of an ES-specific gene Zfp57 as a novel oncogene
Hiroshi Koide1, Yuhki Tada1, Yukari Yamaguchi2, Hiroyuki
Takamura2, Tadayuki Akagi1, Tetsuo Ohta2, Takashi Yokota1(1Department of Stem Cell Biology, and 2Department of
Gastroenterological Surgery, Graduate School of Medical Sciences,
Kanazawa University)
P-33 Polymer-based identification of niche elements for C6 glioma cancer stem cells
Kouichi Tabu, Norihisa Bizen, Tetsuya Taga
(Department of Stem Cell Regulation, Medical Research Institute,Tokyo Medical & Dental University)
P-34 New treatment target gene focusing on GBM stem cells and stem cell niches
Takuichiro Hide, Shigeo Anai, Jun-ichiro Kuroda, Naoki Shinojima,
Keishi Makino, Hideo Nakamura, Shigetoshi Yano, Jun-ichi Kuratsu(Department of Neurosurgery, Kumamoto University Medical School)
P-35 ADAM17 mediates cancer stem cell phenotype in MCF-7 cells
Naoya Hirata, Shigeru Yamada, Yuko Sekino, Yasunari Kanda(Div. Pharmacol., NIHS)

P-36 GDF15 promotes mammosphere formation in breast cancer
Kana Tominaga1, Kunihiko Hinohara1, Teppei Shimamura2, Satoru
Miyano2, Arinobu Tojo3, Noriko Gotoh1(1Division of Molecular therapy, Molecular targets laboratory,
Institute of Medical Science, University of Tokyo, 2Human Genome
Center, Institute of Medical Science, University of Tokyo, 3Division of
Molecular Therapy, Advanced Clinical Research Center, Institute ofMedical Science, University of Tokyo)
P-37 A PI3K-dependent gene expression program that regulates mammosphere
formation of breast cancer cells.
Kunihiko Hinohara1, Teppei Shimamura2, Hiroaki Fukuda1, Kana
Tominaga1, Hajime Kanauchi3, Atsushi Niida2, Keiichiro Tada4, Eiichi
Tuji4, Kotoe Nishioka4, Masaki Mori5, Toshihisa Ogawa4, Satoru
Miyano2, Noriko Gotoh1(1Div. Mol. Therapy, IMS, Univ. Tokyo, 2Lab. DNA Inform. Analysis,
IMS, Univ. Tokyo, 3Dept. Breast. Endo. Surg., Showa Gen. Hosp.,
4Dept. Breast. Endo. Surg., Grad. Sch. Med., Univ. Tokyo, 5Dept.
Gasro. Surg., Grad. Sch. Med., Osaka Univ.)
P-38 Growth factor receptor signaling controls breast cancer stem cells and their niche
Yukino Machida1, Daisuke Iejima1, Anna Mizutani1, Reiko Sakamoto2,
Yusuke Inoue3, Nobutaka Kobayashi4, Naoki Itano4, Nobuaki Yoshida2,
Noriko Gotoh1(1Division of Molecular Therapy, Institute of Medical Science,
University of Tokyo, 2Division of Developmental Engineering,
Institute of Medical Science, University of Tokyo, 3Department of
Diagnostic Radiology, Kitasato University School of Medicine,
4Medical Department, Shinsyu University)
P-39 Amphiregulin/EGFR pathway contributes to mammosphere formation in humanbreast cancer
Hiroaki Fukuda1,2, Kunihiko Hinohara1, Teppei Shimamura3, Toshiki
Watanabe2, Satoru Miyano3, Noriko Gotoh1(1Div. of Mol. Therapy, Inst. of Med. Sci., Univ. of Tokyo, 2Depart. ofMed. Gen. Sci., Graduate School of Front. Sci., Univ. of Tokyo, 3Lab. of
DNA Info. Anal., Inst. of Med. Sci., Univ. of Tokyo)
P-40 MTHFD2, an enzyme in a folate-metabolism, is a key molecule in EGF receptor
tyrosine kinase and regulates lung cancer cell growth.
Tatsunori Nishimura, Asuka Nakata, Arinobu Tojo, Noriko Gotoh(University of Tokyo)
P-41 Novel molecular mechanisms of acquired resistance to gefitinib in Non-small celllung cancer
Asuka Nakata1, Ryo Yoshida2, Rui Yamaguchi1, Mai Yamauchi1, Ikuyo
Yoshino1, Yoshinori Tamada1, Andre Fujita1, Adi F Gazdar3, Teppei
Shimamura1, Seiya Imoto1, Tomoyuki Higuchi2, Masaharu Nomura4,
Satoru Miyano1, Noriko Gotoh1(1Institute of Medical Science, The University of Tokyo, 2Institute of
Statistical Mathematics, 3University of Texas, 4Tokyo Medical
University)

参加者へのご案内とお願い
1．参加登録について
1-1．受付場所：東京大学 伊藤国際学術研究センターB2 伊藤謝恩ホール（〒113-0033 東京都文京区本郷 7-3-1）
1-2．受付時間：5 月 17 日（金） 9 時 00 分から
1-3．参加費：5,000 円
2．発表について
2-1．発表形式
・PowerPoint を用いて作成したデータを、リモートプレゼンシステム（演台上に設置されたマウスまたはキーボードを操作するシステム）を用いての発表となります。
（スライドは使用できません。
）
2-2．データ受付
1）ファイル名は「演題番号演者名.ppt」としてください。必ずバックアップ用のデータも、お持ちくださるようお願い致します。
2）ご講演の一つ前のセッション開始までに、必ず PC 受付にて試写を終えて頂きますようお願い致します。
3）PC 受付では、PC 本体（Windows または Macintosh）あるいは、メディア（CD-R または USB メモリー）で受付させて頂きます。
4）メディア持ち込みの場合、受付したデータは発表用 PC にインストールします。発表用
PC の OS は Windows XP、Vista、Windows7 で、アプリケーションは PowerPoint 2000
～2010 です｡発表後のデータは、シンポジウム終了後に事務局で削除致します。
5）PC 本体持ち込みの場合、Windows、Macintosh 両方共に可能です。
・外部モニター接続端子（MiniD-sub15 ピン）を確認の上、コネクタを必要とする場合は必ず持参ください。AC アダプターは忘れないようお願い致します。
・予め、スクリーンセイバーならびに省電力設定は【なし】にしてください。
・PC 本体持込の場合でも、CD-R・USB メモリーに保存したバックアップデータをご用意ください。
6）動画のある方やアニメーション効果を多用される場合は、ご自身の PC をご持参ください。
3．ポスターセッションについて
3-1．ポスター会場
・多目的スペース
3-2．ポスター貼付
・5 月 17 日（金）9 時から・通知されたポスター番号に従い、掲示をお願い致します。
3-3．ポスター発表・ポスターは 2 日間同一ポスターの貼付となります。
・演題番号 P-1～P-21 は 17 日（金）の発表、P-22～P-41 は 18 日（土）の発表となります。
3-4．貼付パネル
・パネルの大きさは全体で縦 240cm×横 90cm です。

（演題番号は事務局準備）
・演題名・演者名・所属名は縦 20cm×横 70cm、本文は縦 220cm×横 90cm になっております。
3-5．ポスター撤去
・5 月 18 日（金）14 時 30 分から 17 時 00 分まで
・ポスターの撤去は各位の責任で行ってください。時間内に撤去されないポスターは事務局にて処分させていただきますので、予めご了承ください。
4．問合せ先第 11 回幹細胞シンポジウム 事務局

久保田美和子（筑波大学医学医療系血液内科）
e-mail : m-kubota@md.tsukuba.ac.jp
Tel : 029-853-3127〒305-8575

Fax : 029-853-8079

茨城県つくば市天王台 1-1-1幹細胞シンポジウムホームページ
http://www.celldiff.med.keio.ac.jp/simpo.html

Registration Hours and PC/Data Registration
Registration Hours : May 17（Fri） 9：00am THE UNIVERSITY OF TOKYOITO INTERNATIONAL RESEACH CENTER
PC/Data Registration :1. Please check your presentation date and time, and bring your PC/Data to the PC desk next to
the registration desk at least one session prior to your scheduled lecture.
2. Please bring backup of your presentation data (USB flash memory). Only the software“PowerPoint” is allowed.
3. Please check your PC’s “MiniDsub-15 pin”. If your PC
doesn’t have pins, please bring a converting adaptor. **MiniDsub-15 pin is a junction part of a cable which connects
your PC with a projector.
4. If you prefer to bring your own PC for the presentation,please do not fail to bring your AC adapter.

交通アクセス・周辺図

千
代
田
線

丸ノ内線
大江戸線

伊藤国際学術研究センター〒113-0033 東京都文京区本郷 7-3-1 03-5841-0779
●地下鉄
●地下鉄
●地下鉄
●バス
●バス
●バス

丸ノ内線 本郷三丁目駅 徒歩8分
大江戸線 本郷三丁目駅 徒歩6分
千代田線 湯島駅または根津駅 徒歩15分
東京駅丸の内北口・・・「東43荒川土手操車所前」行・・・東大赤門前下車
上野駅前・・・「学01東大構内」行・・・東大龍岡門下車
御茶ノ水駅前・・・「学07東大構内」行・・・東大龍岡門下車

THE UNIVERSITY OF TOKYOITO INTERNATIONAL RESEACH CENTER

http://www.u-tokyo.ac.jp/ext01/iirc/index.html

B2
ポスター会場
Venue for Poster
Presentation

総合受付
Registration Desk

講演会場
Venue for Oral Presentation