The 4th Taiwan-Japan Conjoint Slide Conference

国際病理アカデミー

第4回 日本 − 台湾
スライドカンファレンス
The 4th Taiwan-Japan Conjoint Slide Conference
2012年度 台日切片討論會

日会時：2012年10月26日（金）〜 27日（土）場：公益財団法人がん研究会がん研究所

Oct. 26-27, 2012 TOKYO

Date: October 26(Fri)−27(Sat), 2012
Venue: The Cancer Institute, Japanese Foundation for Cancer Research

世話人：石川雄一 公益財団法人がん研究会がん研究所病理部部長

Conference President: Yuichi Ishikawa
Chief, Department of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research国際病理アカデミー（IAP）

第 4 回日本 - 台湾スライドカンファレンス
2012 年度台日切片討論會
The 4th Taiwan-Japan Conjoint Slide Conference

プログラム・抄録集
Program・Abstract

世話人：石川雄一

公益財団法人がん研究会がん研究所病理部部長

Conference President: Yuichi Ishikawa
Chief, Department of Pathology,
The Cancer Institute, Japanese Foundation for Cancer Research

第 4 回日本 - 台湾スライドカンファレンス
事務局

Secretariat of
4th J-T Conjoint Slide Conference

公益財団法人がん研究会がん研究所病理部内〒 135-8550 東京都江東区有明 3-8-31
Tel: 03-3570-0448

The Cancer Institute,Japanese Foundation for Cancer Research
3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, JAPAN
Tel: +81-3-3570-0448

Conference staff
Hiroaki Kanda, Naoko Inoshita, Noriko Motoi
Hironori Ninomiya, Tomo Osako, Yoshiya Sugiura, Eisaku Miyauchi
Yumiko Toriyama, Yuki Takano and Yuichi Ishikawa

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IAP 第４回日本 - 台湾合同スライドカンファレンス開催にあたり下記の皆様よりご支援を賜りました。
ここに深甚なる感謝の意を表しお礼を申し上げます。

IAP 第４回日本 - 台湾合同スライドカンファレンス会長

石川国際病理アカデミー（IAP）
第 4 回日本 - 台湾スライドカンファレンス概要
2012 年度台日切片討論會議程
Agenda for the Fourth Taiwan-Japan Conjoint Slide Conference

雄一

≪寄付金≫

日にち・Date:2012 年 10 月 26 日（金）〜 27 日（土）October 26(Fri) - 27(Sat), 2012

場所・Venue:

公益財団法人がん研究会がん研究所 吉田記念講堂（〒 135-8550 東京都江東区有明 3-8-31）
Yoshida Memorial Hall, The Cancer Institute,Japanese Foundation for Cancer Research)(3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, JAPAN

ナカライテスク株式会社
株式会社バイオシス
株式会社山口薬品
株式会社池田理化
オリンパスメディカルサイエンス販売株式会社

スケジュール・Schedule:
October 26 (Fri)10 月 26 日（金）15:00

Opening ceremony

15:05 - 18:00 Slide conference
18:00 - 19:15 Poster session≪企業展示≫

株式会社三啓≪プログラム・抄録集広告≫

株式会社キーエンス
サクラファインテックジャパン株式会社
第一三共株式会社
株式会社臨床病態医学研究所
ロシュ・ダイアグノスティックス株式会社
エーザイ株式会社
ダコ・ジャパン株式会社

19:30 - 21:30
		
		
		

Reception at“Restaurant Nakamura Komei”(Ariake Park Building 2F, 3-1-28, Ariake,
Koto-ku, Tokyo, 135-8550, JAPAN)
TEL: +81-3-3599-3636

October 27 (Sat)09:00 - 17:00 Social excursion: Tokyo Skytree tour
10 月 27 日（土）		(Departure place：Hotel Sunroute Ariake		
3-6-6 Ariake, Koto-ku, Tokyo, 135-0063, JAPAN)
TEL: +81-3-5530-3610
18:00 - 19:00 Farewell party at "The Lady Crystal"
19:00 - 21:00
		
		
		
		

Cruising(Departure place：Crystal Yacht Club
1F SeafortSquare 2-3-16, Higashi-Shinagawa,Shinagawa-ku, Tokyo, 140-0002, JAPAN)
TEL: +81-3-3450-4300

中外製薬株式会社
株式会社ニチレイバイオサイエンス
ファイザー株式会社
武藤化学株式会社
ライカマイクロシステムズ株式会社

以上、プログラム・抄録集編集時点での情報です。

参加費・Registration Fees
スライドカンファレンス＋レセプション：5000 円
都内観光＋送別会：10,000 円（国内からの参加者）
Slide Conference + Reception : 5,000 JPY
Excursion + Farewell party : 5,000 JPY (only from Taiwan)

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鉄道のご案内Railroad map

交通のご案内㕲㐨ࡢࡈ᱌ෆ Railroad map

AccessThe Cancer Institute(Venue)Ariake Station
有明

Restaurants Nakamura Komei（The place of welcome party）

Kokusaitenjijou Station
国際展示場

Tokyobay Ariake Washington HotelTokyo Big Sight
羽田空港からのアクセス࠿ࡽࡢ࢔ࢡࢭࢫ
⩚⏣✵From
TokyoInternational
International Airport(Haneda
Airport(Haneda Air
From
Tokyo
Airport)port)

Hotel Sunroute Ariake

ホテルサンルート有明

Rinkai Line

Tennozu Isle

Tokyo Monorail

天王洲アイルTokyo International Airport(Haneda Airport)

The Cancer Institute / Cancer Institute Hospital,
Japanese Foundation for Cancer Research
3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, JAPAN
Phone: +81-3-3520-0111(Reception)8

Hotel Sunroute Ariake

3-6-6 Ariake, Koto-ku, Tokyo, 135-0063, JAPAN
Phone: +81-3-5530-3610

Restaurant Nakamura Komei

Ariake Park Building 2F
3-7-11 Ariake, Koto-ku, Tokyo, 135-0063, JAPAN
Phone: +81-3-3599-3636

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発表方法について

How to present each case

スライドカンファレンス

Slide Conference・ One moderator chairs one case.

・ 各症例の司会・進行は moderator/ 座長が務めます。
・ はじめに discussant/ コメンテータによる担当症例の解説、鑑別診断。
（発表時間 5 分、PowerPoint 使用）
・ 次に presenter/ 症例発表者による症例の解説、解答（発表時間 5 分、PowerPoint 使用）

・ First, discussant presents his/her comments on thecase and shows differential diagnoses (5 min. by
PowerPoint).
・ Second, presenter gives his/her diagnosis of thecase and gives comments.

会場案内図Hall map఍ሙ᱌ෆᅗ Hall map

CancerInstitute1F
YoshidaMemorial
Auditorium

PosterSessionAtriumcloakroom

CancerInstitute
Entrance

W/C

・ Then, the case is open for discussion.

EV・ 最後に総合討論（5 分）
発 表 会 場 で 用 意 さ れ る の は Windows パ ソ コ ン、PowerPoint/Office 2007 (Windows) です。Mac 対応の準備はされていません。発表ファイルは CD、USB
いずれでも受付が可能です。

At the venue, only Windows laptops are available,using PowerPoint/Office 2007. Mac is not available.
Computer files should be submitted with a USB
memory or a CD.

ポスター

Poster・ 発表時間 4 分、総合討論 2 分です。

・ 4 min for Presenter, then Open discussion 2 min・ Poster size, Height×Width(cm): 100×80

・ ポスターの大きさは縦 100cm ×横 80cm です。

convenience
store

W/C

CancerInstitute
Hopspital Entrance

CancerInstituteHospital1F


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Slide Conference Time Schedule

Oral session

Poster session

5 min for Discussant, 5 min for Presenter, then Open discussion 5 min

Time: 18:00-19:15
4 min for Presenter, then Open discussion 2 min

15:00-15:05

Opening Ceremony: Yuichi Ishikawa / Osamu Matsubara

Time

Case No

Moderator

15:05-15:20

Case 1 (T-1)

60 years old. Male. Nasal cavity lesion............................................................... 10		15;20-15:35

Case 2 (J-1)

		
15:35-15:50

Case 3 (T-2)

		
15:50-16:05

Case 4 (J-2)

		
16:05-16:20

Case 5 (T-3)

		

Ying-Tai Jin
Takeshi Fujii
Tseng-Tong Kuo
Masanori Hisaoka

17:10-17:25

Case 8 (J-4)

		
17:25-17:40

Case 9 (T-5)

		
17:40-17:55

Tetsuo Kondo

Poster: T-1

Ocular Sparganosis.................................................................................................................. 30

Yoko Yonemori
Poster: T-2

Toshiaki Morito
Chen-Lin Chi

Pao-Shu Wu

Reiko Kumagai

Teh-Ying Chou

Yuko Minami

Hua-Lin Kao

Yoko Yonemori
Poster: T-3

72 years old. Male. Lung tumor........................................................................ 20

Masayuki Noguchi Tai-Di Chen
Yasunori Ota
Chia-Yin Chu

Noriko Motoi

Jen-Fan Hang

Poster: J-2
Poster: J-3

Poster: J-4

Mu-Zon Wu

Takashi Tasaki
Chih-Ping Li

Interobserver agreement in the nuclear grading of primary pulmonary adenocarcinoma........... 48

Yosimasa Nakasato

A Case of Allergic Bronchopulmonary Mycosis (ABPM) caused by Schizophyllum commune..... 50

Yung-Hsiang Hsu
Poster: J-5

Swei-H. Tsung

A case report of autopsy.......................................................................................................... 46

Liang-Che Chang

Yoshiya Sugiura

Shien-Tung Pan

A case of Alport syndrome with diffuse leiomyomatosis........................................................... 44

Liang-Che Chang

Chien-Feng Li

Hsiao-Bai Yang

Ultrastructural features of nodal asbestos fibers in Taiwan........................................................ 42

Liang-Che Chang

Kosuke Miyai

67 years old. Male. Submucosal tumor of stomach........................................... 26

Hsuan-Ying Huang Yutaka Takazawa

Poster: J-1

Yung-Hsiang Hsu

Primary pure squamous cell carcinoma of the breast: A case report.......................................... 40

Naoko Inoshita

Sheng-Tsung Chang

19 years old. Female. Breast mass lesion............................................................ 24

Yoshinao Oda

Poster: T-7

Pao-Shu Wu

3-D imaging of human colorectal tissues with optical clearing:
Spatial analysis of the tumor vasculature through transparent specimens................................. 38

Naoko Inoshita

Kenichi Taguchi

62 years old. Male. HBV-positive, liver nodule and splenomegaly (autopsy)........ 22

Mu-Zon Wu

Poster: T-6

Wei-Wen Yu

Appendiceal diverticular disease ? Analysis of 10 cases............................................................. 36

Junko Fujigasaki
Poster: T-5

Page

Fatal pulmonary hypertension due to pulmonary venous occlusive disease
following renal transplantation- an autopsy case report........................................................... 34

Yoko Yonemori
Poster: T-4

Presenter							Lung adenocarcinoma metastasizing into renal angiomyolipoma:
A case report with immunohistochemical and molecular analysis............................................. 32

Junko Fujigasaki

Case 10 (J-5) 74 years old. Male. Pancreatic tumor with peritoneal lesion............................... 28		Moderator

Hsiang-Lin Song32 years old. Male. Nodular lesion of lung........................................................ 18

Case 6 (J-3)

		Cheng-Lin Wu

Poster No

51 years old. Female. Vaginal tumor (Soft tissue tumor).................................... 16

16:40-16:55

Case 7 (T-4)

Page

71 years old. Male. Right infra-auricular mass lesion.......................................... 14

Coffee Break (photo for all speakers)

16:55-17:10

Junji Shibahara

Presenter47 years old. Female. Dyspnea after intake of nutritional supplements.............. 12

16:20-16:40

		Discussant

Y. Takahashi

Molecular detection of micrometastasis in sentinel lymph nodes using
One-Step Nucleic acid Amplification assay for breast cancer patients- Comparison with routine pathological examination............................................................... 52

Yung-Hsiang Hsu

Tomo Osakoᛞ㍳㓸 Abstract10


15:05-15:20

Case 1 (T-1)‫ޣ‬Oral Session‫ޤ‬

11Case 1

History:This 60-year-old male has nasal obstruction for unknown duration. CT reveals an
ill-defined soft tissue mass lesion with heterogenous enhancement in superior aspect ofright nasal cavity, medial to the middle turbinate. The impression was inverted
papilloma or other neoplasms.




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ORAL SESSION

Slide: T-1
Case: 60 years old. Male. Nasal cavity lesion
Moderator: ᣂᙥบ Ying-Tai Jin, DDS, MS
Taiwan Adventist Hospital, Taipei,
Discussant: ᩊේ⚐ੑ Junji Shibahara
Graduate School of Medicine, the University of Tokyo
Presenter:٤ቡḕ℘ Hsiang-Lin Song, M.D.
National Taiwan University Hospital, Hsinchu branch

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15;20-15:35

Case 2 (J-1)

13

Case 2

History:
A 47-year old female was admitted to the hospital who complained dyspnea and coughon exertion. She had taken nutritional supplements during a period of 130days, as a dietaid. On admission, her FEV1.0 was 0.57L, and forced vital capacity was 36.3%.
The chest high-resolution computed tomography (HRCT) revealed diffuse air trapping in
the expiratory phase, and the ventilation scintiscanning showed patchy defects.
She received corticosteroids, bronchodilator and erythromycin; however, her dyspnea
was not improved. About 1 year later, living-donor lobar lung transplantation was
performed.

24

ORAL SESSION

Slide: J-1
Case: 47 years old. Female. Dyspnea after intake of nutritional supplements
Moderator: ⮮੗ਂ჻ Takeshi Fujii,
Toranomon Hospital
Discussant: Cheng-Lin Wu, M.D.
National Cheng Kung University Medical Center
Presenter:٤቞ㇺᢅᤩ Toshiaki Morito1), Ichiro Yamadori2), Katsuya Kato3),
Takahiro Oto4), Koichi Mizobuchi5), Tadashi Yoshino1),
1) Department of Anatomic Pathology; Kagawa Rosai Hospital,
2) Department of Pathology; National Health Organization Okayama Medical Center,3) Department of Radiology; Okayama University Graduate School4) Department of General Thoracic Surgery; Okayama University Graduate School5) Department of Pathology; Okayama University Graduate School

14

15:35-15:50

Case 3 (T-2)

15

Case 3

History:
A 71-year-old man visited ENT clinic because of a right infra-auricularmass for five
years. The mass was movable, non-tender and measuring 4×3cm. There were no
associated symptoms. The tumor mass was surgically removed.

16

ORAL SESSION

Slide: T-2
Case: 71 years old. Male. Right infra-auricular mass lesion
Moderator: ㇳᛚ⛔ Tseng-tong Kuo, M.D., Ph.D.
Chang Gung Memorial Hospital-Linkou
Discussant: ㄭ⮮ືᄦ Tetsuo Kondo
University of Yamanashi
Presenter:٤♿ᛚ㔪 Chen-Lin Chi, M.D., Tseng-tong Kuo, M.D., Ph.D.,
Li-Yu Lee, M.D.
Chang Gung Memorial Hospital-Linkou

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15:50-16:05

Case 4 (J-2)

17

Case 4

History:
Vaginal tumor, 51-year-old female
The patient had been aware of irregular genital bleeding and go to the hospital. Six
cm-sized vaginal, well circumscribed tumor was found by colposcopy. Preoperative
clinical diagnosis of myoma delivery was made, and tumor resection was performed. The
tumor was connected to the left side of vaginal wall by broad stalk. The cut surface of thetumor was yellowish and solid.

26

ORAL SESSION

Slide: J-2
Case: 51 years old. Female. Vaginal tumor (Soft tissue tumor)
Moderator:ਭጟᱜౖ Masanori Hisaoka
University of Occupational & Environmental Health
Discussant: Pao-Shu Wu, M.D.
Taipei Veterans General HospitalPresenter:٤ᾢ⼱⃍ሶ Reiko Kumagai1), Yoshihiro Ohishi, Hiroko Imamura,
Yoshinao Oda
Graduate School of Medical Sciences, Kyushu University,

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16:05-16:20

Case 5 (T-3)

19Case 5History:This 32-year-old man was found to have a nodule over left lower lung on chest
radiograph in routine physical examination. He denied of any history of smoking or
medical event. His occupation is information technologist. Chest CT scans reported a
1.5-cm left lower lobe nodule. The follow-up CT after four months revealed enlargementof the left lower lobe nodule to the size of 1.7cm. Tumor markers CEA, CA-125, CA-199
and SCC were all within normal limits. Routine laboratory studies of peripheral blood
revealed negative results. The patient received wedge resection of left lower lobe.

18

ORAL SESSION

Slide: T-3
Case 3: 32 years old. Male. Nodular lesion of lung
Moderator: ๟ᓼ⋇ Teh-Ying Chou, M.D., Ph.D.
Taipei Veterans General Hospital
Discussant: ධఝሶ Yuko Minami
University of Tsukuba
Presenter: ٤㜞⪇⅑ Hua-Lin Kao, M.D.
Taipei Veterans General Hospital

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16:40-16:55

Case 6 (J-3)

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Case 6History:
A 72-year-old male ex-smoker of 60 pack-years had undergone a high anterior resection,
followed by chemotherapy (Leucovorin+5-Fluorouracil, S-1, FOLFOX-4+Bevacizumab,
FOLFIRI+Bevacizumab) for rectal cancer with liver and sacral bone metastases for a
total of 6 years. A nodal shadow in the right lower lobe of the lung had appeared in spiteof the disappearance of the liver and sacral metastasis, so he was referred to departmentof Thoracic Oncology for a treatment of the pulmonary nodule.
Computed tomography showed an irregular nodule in the right lower lobe confirmed tobe active by positron emission tomography, while there were active lesions on neither
the liver nor sacral bone. Right lower lobectomy with lymphadenectomy was performed.
The pulmonary lesion was assumed to be primary lung cancer and right lower lobectomy
with lymphadenectomy was performed. The cut sections revealed a whitish solid nodule
encircled by a grey-whitish component with a maximum diameter of 4.5 cm. The centralcomponent was pathologically diagnosed as small cell lung cancer (SCLC), 30% of theentire tumor, and the surrounding area was adenocarcinoma (60%) with papillary,acinar and lepidic components. Both the components showed immunoreactivity tothyroid transcriptional factor 1 (TTF-1) while synaptophysin and CD56 were detected
only in the SCLC component. Interestingly, the SCLC component was
immunohistochemically positive for ALK whereas the adenocarcinoma component was
negative.
1) How is the immunoreactivity of SCLC component to ALK interpreted?
2) What is the driver mutation of adenocarcinoma component expected to be?
1 Toyokawa G, Taguchi K et al.

J Thorac Oncol (accepted).

28

ORAL SESSION

Slide: J-3
Case: 72 years old. Male. Lung tumor
Moderator: ㊁ญ㓷ਯ Masayuki Noguchi
University of Tsukuba
Discussant: Tai-Di Chen, M.D.
Chang Gung Memorial Hospital-Linkou
Presenter:٤↰ญஜ৻ Kenichi Taguchi1), Gouji Toyokawa2), Taro Ohba2), Yosuke
Morodomi2), Tomoyoshi Takenaka2), Fumihiko Hirai2), Masafumi Yamaguchi2),
Takashi Seto2), Mitsuhiro Takenoyama2), Kenji Sugio2), Yukito Ichinose2)
1) Cancer Pathology Laboratory, Institute for Clinical Research,
National Kyushu Cancer Center2) Department of Thoracic Oncology, National Kyushu Cancer Center

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16:55-17:10

Case 7 (T-4)

23Case 7

History:
Tracing back the patient's medical history, computed tomography(CT) scans in January
2007, when he was 62 years old, revealed a 1cm hepatic nodule and splenomegaly bothconsidered to be HBV-related. In March 2008, abdominal CT scans showed rightinguinal, abdominal, mesenteric and retroperitoneal lymphadenopathy and persistentsplenomegaly. Biopsies of inguinal lymph node(2008-03-6524). Complete staging
procedures revealed an Ann Arbor stage ΦA disease of lymphoma with an IPI score of
3. He was treated with 6 cycles of R-CHOP and achieved complete remission.
Fifteen months later in August 2009,a left parotid nodular lesion was noted and abiopsy (2009-08-6923) was performed. Unfortunately a relapse with systemic
lymphadenopathy occurred in March 2010. He was then treated with oral
cyclophosphamide and prednisolone with a stable disease until a subsequent relapse
occurred in May 201l when he experienced fever and weightloss with elevated LDH.
In August 2011 he presented with fever, chillness, dry cough, dysuria, urinary
frequency, and an episode of falling down. Imaging studies revealed pneumonia and a
subdural hemorrhage in the right frontal and temporal regions. Laboratory examination
revealed elevated C-reactive protein, pancytopenia, and hepatitis B virus infection.
Bloody diarrhea was noted during this admission with pending hypovolemic shock andhe underwent exploratory laparotomy, which revealed a bleeding lesion and a hematoma
at ileum. A segmental resection of Ileum (2011-09-6320) was performed. His condition
deteriorated and he passed away 2 weeks after operation.

20

ORAL SESSION

Slide: T-4
Case: 62 years old. Male. HBV-positive, liver nodule and splenomegaly (autopsy)
Moderator: 吳木榮藀ᧁ᭢ Mu-Zon Wu, M.D.
National Taiwan University Hospital
Discussant: ᄢ↰ᵏᓼ Yasunori Ota
Toranomon HospitalPresenter: ٤ᒛ⡛ቬ Sheng-Tsung Chang, M.D.
Chi-Mei Medical Center

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17:10-17:25

Case 8 (J-4)

25

Case 8

Title: A gradually enlarged breast mass in a young woman
History:
A 19-year-old woman noticed a painless mass of the right breast 2 years ago. She hadno exceptional past, familial or pregnant history. During a follow-up under a diagnosisof lipoma the breast mass gradually enlarges from 3 cm to 10 cm in the largest diameter.
Ultrasonographic examination revealed a poorly-marginated, uniformly-isoechoic massof the right breast. No significant finding was observed in the left breast.
Core needle biopsy was performed.

30

ORAL SESSION

Slide: J-4
Case: 19 years old. Female. Breast mass lesion
Moderator: ዊ↰⟵⋥ Yoshinao Oda,
Graduate School of Medical Sciences, Kyushu University
Discussant: Chia-Yin Chu, M.D.
Taipei Medical University HospitalPresenter:٤ችዬᒄテ Kosuke Miyai1), Kenichi Iwaya, Ryoko Kikuchi,
Osamu Matsubara
National Defence Medical College,

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17:25-17:40

Case 9 (T-5)

27Case 9

History:
A 67-year-old man felt abdominal fullness for one month. There was no bloody or tarrystool.
Panendoscope study and abdominal CT revealed a submucosal tumor, measuring up to 3
cm, with
central ulceration located at the low body of stomach. He received partial gastrectomy
and the tumor was totally excised.

22

ORAL SESSION

Slide: T-5
Case: 67 years old. Male. Submucosal tumor of stomach
Moderator: 㤛₵⿊ Hsuan-Ying Huang, M.D.
Chang Gung Memorial Hospital- Kaohsiung
Discussant: 㜞Ỉ⼾ Yutaka Takazawa
University of Tokyo
Presenter:٤᧘ஜㅩ Chien-Feng Li, M.D.
Chi-Mei Medical Center

28

17:40-17:55

Case 10 (J-5)

29

Case 10

History:
74 year-old male‫ޣ‬Chief complaint‫ ޤ‬Back pain‫ޣ‬Present illness‫ޤ‬The patient had suffered from back pain since 8 months before
operation. Six months before operation, he developed upper abdominal pain. At theprevious hospital, he was diagnosed as pancreatic body cancer by blood biochemistry andCT scan. The values of CEA and CA19-9 were 10 [ng/ml] and 453 [U/ml], respectively.
Because the tumor extended to the root of celiac artery, it was considered borderline
unresectable at that time. Then, he had been treated by gemcitabine. CA19-9 was
reduced a lot, being 44 [U/ml] at the time of one month before operation. On CT scan, themass had withdrawn from the root of celiac artery. Neither ascites nor peritoneal mass
was detected. He was then referred to our hospital. The tumor was considered resectable
and surgical resection was performed.
‫ޣ‬Clinical diagnosis‫ޤ‬Pancreatic body cancer‫ޣ‬Operation‫ޤ‬Distal pancreatectomy with celiac artery resection (DP-CAR) and left gastric arteryreconstruction was performed.
‫ޣ‬Frozen section‫ޤ‬
During the operation, two nodules were found on the gastric serosa (4mm in diameter)and on the serosa under the diaphragm (5mm in diameter). On frozen section, they were
histologically diagnosed as GIST and adenocarcinoma at that time, respectively.
‫ޣ‬Gross findings of the DP-CAR operation specimen‫ޤ‬Poorly demarcated white hardmass with a cyst, 75x55x28mm in size, was found in the pancreatic body. Grossly there
was neither papillary nor nodular lesion on the serosa.
‫ޣ‬H&E staining‫ޤ‬(A) Pancreatic body, main cut surface of the pancreatic body cancer.
(B) Pancreatic body.

32

ORAL SESSION

Slide: J-5
Case: 74 years old. Male. Pancreatic tumor with peritoneal lesion
Moderator: ర੗♿ሶ Noriko Motoi
the Cancer Institute, Japanese Foundation for Cancer Research
Discussant: Jen-Fan HANG, M.D.
Taipei Veterans General HospitalPresenter:٤᧖ᶆༀᒎ Yoshiya Sugiura1), Noriko Motoi1), Susumu Kirimura1), Hiroaki
Kanda1), Akio Saiura2), Yo Kato1), Yuichi Ishikawa1)
1)Department of Pathology; Cancer Institute, Japanese Foundation for Cancer
Research (JFCR)
2) Hepatic, Biliary and Pancreas Center, Cancer Institute Hospital, JFCR

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18:00-19:15‫ޣ‬PosterSession‫ޤ‬

31

Poster: T-1
Title: Ocular Sparganosis
Presenter:٤᷿உ㔒 Wei-Wen Yu M.D., Jyh-Seng Wang M.D., PhD
Kaohsiung Veterans General Hospital, Kaohsiung
Moderator: Yoko Yonemori
Chiba University Graduate School of Medicine

Figures

34

POSTER SESSION

Abstract
Human sparganosis is reported mostly from Southeast Asian countries, caused bylarval forms of canine/feline tapeworms, Spirometra species. Human can get infected byingesting contaminated water or uncooked meat carrying their larva.
A 34-year-old lady presented to our hospital due to swelling of her left eye. Left
exophthalmos was noted and orbital computed tomography revealed enlargement ofsuperior oblique muscle. Her thyroid function tests were normal. Under the impressionof idiopathic orbital inflammation syndrome, she was treated with oral prednisolone.
Three months later, she visited a local clinic with irritation and painful sensation of her
left eye. Unexpectedly, a white, ribbon-like soft worm was removed from the conjuntiva.
The specimen sent for pathologic examination contained three pieces of white, longtissue, measuring up to 5.5 x 0.2 x 0.1 cm. Microscopically, the body wall of the organism
consists of tegument with smooth muscle and a row of tegumental cells. The
parenchyma is composed of calcereous bodies, mesenchcymal fibers and smooth muscles.
Neither a scolex nor internal organ is present. The pathologic diagnosis is ocularsparganosis.
The migrating spargana can cause various symptoms depending on the final
location of the host. Most patients were reported having subcutaneous, orbital, or
central nervous system lesions. Currently there is no recommended medical therapy andcomplete surgical removal is the choice. After removal of the sparganum, the patient
showed much improvement of the left eyelid thickening and exophthalmos. No signs ofrecurrence were noted during one-year follow-up.

32

33

18:00-19:15

Poster: T-2
Title: Lung adenocarcinoma metastasizing into renal angiomyolipoma: A case reportwith immunohistochemical and molecular analysis
吳保樹 Pao-Shu Wu., Chin-Chen Pan.
Presenter:٤藀଻᮸
Taipei Veterans General Hospital
Moderator: Yoko Yonemori
Chiba University Graduate School of Medicine

36

POSTER SESSION

Abstract
Tumour-to-tumour metastasis is a rare phenomenon and less than 100 cases havebeen reported since its first description in 1902. The most common donor intumour-to-tumour metastasis is lung adenocarcinoma whereas the most common
recipient malignant and benign tumours are renal cell carcinoma and meningioma,
respectively. Here we report a case of lung adenocarcinoma metastasizing into renal
angiomyolipoma (AML). Interestingly, the two neoplasms did not occur concomitantly
but with a nine-year interval after surgical removal of the primary lung tumour. Studies
from morphology and immunohistochemistry showed the lesion within renal AML is oflung origin. Further molecular analysis revealed both the primary lung adenocarcinoma
and the metastatic tumour in renal AML carried the same epithelial growth factor
receptor (EGFR) exon 19 deletion. To our knowledge, this is the first case of tumour
metastasizing into renal AML reported in Asia and the second case of lungadenocarcinoma metastasizing into renal AML in the world.

34

35

18:00-19:15

Poster: T-3
Title: Fatal pulmonary hypertension due to pulmonary venous occlusive disease
following renal transplantation- an autopsy case report
Presenter:٤⸵᳗␽ Yung-Hsiang Hsu1, M.D., Ming-Che Lee2 , M.D.
1) Department of Pathology, Buddhist Tzu-Chi General Hospital2) Department of Pathology, General Surgery1, Buddhist Tzu-Chi General
Hospital, Hualien,
Moderator: Yoko Yonemori
Chiba University Graduate School of Medicine

Key words: pulmonary hypertension, pulmonary venous occlusive disease (PVOD), renaltransplantation

38

POSTER SESSION

Abstract
We are presenting a case of fatal pulmonary hypertension occurred in a 57-year-old
woman five years after a renal transplantation due to end stage kidney disease.
Premortem investigations failed to reveal the cause for the pulmonary hypertension.
The postmortem histological features in the lung at the autopsy were consistent with adiagnosis of pulmonary venous occlusive disease (PVOD) characterized by fibrotic
occlusion in the venules of pulmonary septum. The possible pathogenesis will be
discussed.

36

37

18:00-19:15

Poster: T-4
Title: Appendiceal Diverticular Disease – Analysis of 10 cases
Presenter:٤ᬢᦇ⊕ Hsiao-Bai Yang1,4, Yun-Wu Deng2, Tein-Kuei Cheng3
1) Department of Pathology, 2) Department of Emergency Medicine,3) Department of Surgery, Ton Yen General Hospital, Hsinchu,
4) Department of Pathology, Medical College, National Cheng Kung
University, Tainan,
Moderator: Junko Fujigasaki
The Jikei University School of Medicine

40

POSTER SESSION

Abstract
Diverticulosis of the appendix is typically identified incidentally during pathologicalexamination following an appendectomy. The occurrence of this disease is rare andeasily ignored. Only one case has been reported in Taiwan. In this study, we report 10
cases, all of which were diagnosed after an operation. The incidence rate was 0.88%.
The patients comprised 8 men and 2 women. The patient age distribution was 22 to 71
years, with an average of 39.7 years. All the diverticula were acquired. Eight patients
presented with acute appendicitis and diverticulitis, one presented with a normal
appendix and acute diverticulitis, and one presented with periappendicitis with a noninflammatory diverticulum. The number of diverticula for each patient ranged from 1 to6. Multiple diverticula were observed in 80% of the patients. For 90% of the patients,
the diverticula were located in the distal portion of the appendix. The perforation
rate was 70%. Diverticula can be preoperatively diagnosed with careful differentiationof the clinical presentations. High-resolution ultrasounds or CT scans may facilitate
diagnosis. The recommended treatment for asymptomatic appendiceal diverticulosis isprophylactic appendectomy because of the high perforation rate and significant
association with neoplasia. We advise conducting thorough pathologic examinations andobtaining additional sections to identify a higher number of diverticula, perforations,and associated neoplasms.

38

39

18:00-19:15

Abstract
Angiogenesis is the process in which endothelial cells divide and migrate to form newcapillaries which support the growth of tumor. Measuring microvessel density in 2-D
histology has been developed to assess the angiogenesis in human tumors, and serves as
a prognostic indicator of colorectal carcinoma. However, it is usually difficult to evaluate
the architecture and density of perspective spatial vasculature with the method due tothe difficulty to resolve complex tumor vasculature in space in microtome-based 2-D
histology. Of the currently available imaging methods, confocal microscopy generates
high resolution images by excluding out-of-focus signals for 3-D reconstruction, yet thein-depth imaging is obscured by the opacity of most tissues. In this research, we applied
optical clearing to generate transparent human colon tissue of normal and cancerous
parts, thus allowing better resolution of in-depth confocal imaging. Optical clearing is atechnique to match the refractive index of tissue constituents, so that light scattering is
reduced. With reconstruction of serial high resolution images of the immuno-labeledvasculature in optically cleared specimens along the focal path, we obtained a panoramic
3-D visualization and an image of distinct 3-D architecture of tumor vasculature. In
addition, we devised a voxel-based quantitative indicator named “spatial microvessel
density” to quantitatively evaluate the density of 3-D vasculature and to correlate withits morphology. We found a significant increase in “spatial microvessel density” incolorectal carcinoma. In addition, our 3-D imaging method was comparable tomicrotome-based 2-D histology as an add-on to conventional planar analysis. In
summary, we integrated immuno-staining, optical clearing and confocal microscopy tovisualize 3-D vasculature in normal colon mucosa and colorectal carcinoma. This 3-D
histological method provides a useful approach for qualitative and quantitative analysesof angiogenesis in human tumors.

42

POSTER SESSION

Poster: T-5
Title: 3-D imaging of human colorectal tissues with optical clearing: Spatial analysis of
the tumor vasculature through transparent specimens
Presenter: Yuan-An Liu1, ٤ẘᙗ᫠ Shien-Tung Pan2,3, Yung-Chi Hou4, Shih-Rung Peng1,
Shiue-Cheng Tang1, 5, Yuan-Chiang Chung4, 6
1) Department of Chemical Engineering, National Tsing Hua University,
Hsinchu2) Department of Pathology, National Taiwan University Hospital – Hsinchu
Branch, Hsinchu
3) Department of Laboratory Medicine, Miao-Li General Hospital,
Miao-Li City
4) Department of Surgery, National Taiwan University Hospital – Hsinchu
Branch, Hsinchu
5) Institute of Biotechnology, National Tsing Hua University, Hsinchu
6) Department of Surgery, Cheng Ching General Hospital – Chung Kang
Branch, TaichungModerator: Junko Fujigasaki
The Jikei University School of Medicine

40

41

18:00-19:15

Poster: T-6
Title: Primary pure squamous cell carcinoma of the breast: A case report
Presenter:٤㈕ℰ㓶 Swei H. Tsung1,M.D., Chen Chia Chen2, M.D.,
Ching Chao Fan3, M.D.
1) Department of Pathology, 2) Department of Surgery,3) Department of Radiation Oncology, St Mary Hospital, Loudong, Yilan
Moderator: Naoko Inoshita
The Cancer Institute, Japanese Foundation for Cancer Research

44

POSTER SESSION

Abstract
We report a 50-year-old woman who presented a rapidly growing large breast tumor,
diagnosed as pure squamous cell carcinoma of the breast (PSCCB). PSCCB is a rare
condition. The reported incidence is 0.1% of all ductal carcinoma. The histogenesis is
unclear. Patients typically report a breast mass that enlarges over a period of 2 to 3
weeks. Metastsis to axillary lymph nodes is uncommon. Estrogen and progesterone
receptors are negative in 90% of cases. There were only two reported cases of Her2/neu
gene overexpression. Therefore, hormonal therapy provides minimal assistance to the
management of such cases.
The initial treatment is usually surgery. In some cases, complete excision of thetumor may be enough, while other cases, a mastectomy is required. It could be argued
that axillary lymph nodes dissection might be omitted except in cases with palpablenodal disease.
In the literature, the report on the role of neoadjuvant therapy is controversial.In ourcase, neoadjuvant therapy using cytoxan, epirubicin and fluorouracil was ineffective.
Postoperative adjuvant therapy for PSCCB has generally been carried out in the same
way as therapy for more common types of breast cancer . However, optimal choice ofchemotherapeutic agents is unknown. Also the role of adjuvant radiation therapy
remains unknown.
The rarity of the disease makes it difficult to draw firm conclusion on the course of
the disease and the overall prognosis. The SEER database from 1988 to 2001 included
137 cases of PSCC B with a 5 year survival of 64%.
In conclusion, PSCCB is rare. The prognosis and clinical course of this type of breast
cancer remain mostly unknown. Effective adjuvant or neoadjuvant therapy is notavailable. The usefulness of adjuvant radiation therapy has not been extensively studied.
Further studies should be carried out to solve these issues.

42

43

18:00-19:15

Poster: T-7
Title: Ultrastructural features of nodal asbestos fibers in Taiwan
Presenter:٤藀ᧁ᭢吳木榮 Mu Zon Wu, M.D.
National Taiwan University Hospital
Moderator: Naoko Inoshita
The Cancer Institute, Japanese Foundation for Cancer Research

46

POSTER SESSION

Abstract
Asbestos, a fibrous miracle mineral, had extremely good resistance to thermal andchemical breakdown for many variant purposes of industrial and commercial
applications.
In current literatures, long-termed occupational or environmental exposure toasbestosis were associated with progressive interstitial fibro-hyalinization of lung with
disseminated asbestos-associated lymphadenopathy, malignant mesothelioma or othermalignancies such as carcinoma of lung, esophagus and/or larynx.
Also, there were significant differences in crystalline structures and chemicalcompositions of asbestos, with the fiber structure, dimension and bio-persistence
related to marked differences in potency for causing disease in humans.
In order to explore the geographic characters of asbestos fibers in the regional thoracic
lymph nodes in Taiwan, we examined 5 cases of asbestos-associated lymphadenopathy,
diagnosed from Jan. 2012 to June 2012, by electron microscopic examination. Twotypes of crystalline structures of amphibole asbestos fiber and chrysotile asbestos fiber
were observed in the 5 case of asbestos-containing lymph nodes. The ratio of amphibole
asbestos to chroysotile asbestos was 4:1.
In summary, our recent study of ultrastructural features for asbestos fibers in theregional thoracic lymph nodes of cases of asbestos-associated lymphadenopathy
disclosed more predominant presence of amphibole asbestos than chrysotile asbestos in
Taiwan.

44

45

18:00-19:15

Poster: J-1
Title: A case of Alport syndrome with diffuse leiomyomatosis
Presenter:٤ ↰ፒ⾆༹ Takashi Tasaki
Department of 2nd Pathology and cell biology; University of Occupational
and Environmental HealthModerator: Liang-Che Chang
Keelung Chang Gung Memorial Hospital

48

POSTER SESSION

Abstract:
Alport syndrome (AS) is a hereditary nephropathy with progressive hematuric
nephritis with ultrastructural changes of the glomerular basement membrane,
sensorineural deafness, and variable ocular abnormalities (lenticonus, macular flecks,
and congenital cataracts). Inheritance is X-linked in about 85% of the cases, caused bydifferent mutations in the COL4A5 gene. X-linked Alport syndrome is rarely seen in
combination with diffuse leiomyomatosis (DL), a benign hypertrophy of the visceralsmooth muscle, mostly of the esophagus. The AS-DL complex is due to deletions of the
5'-end of both the COL4A5 and the COL4A6 genes, respectively.
We described a case of a 16-years-old girl affected by Alport syndrome with DL,
hematoureic heohritis and intermittent exotropia. She has a familial history of AS-DL.
Since early childhood, she was noticed asymptomatic leiomyomatosis and has taken wait
and see approach. She had total esophagectomy because DL has slowly enlarged.
Macroscopically, the esophagus was dilatated and became markedly thickened
muscularis propia and musclaris mucosa. Microscopically, we recognized hyperplasia ofsmooth muscle cells in thickened muscle.

46

47

18:00-19:15

Poster: J-2
Title: A case report of autopsy.
Presenter:٤᧘ᴦᐔ Li Chih-Ping, Yang Yang, Eriko Abe, Mieko Uno, Koyu Suzuki
Department of Pathology, St. Luke’s International Hospital
Moderator: Liang-Che Chang
Keelung Chang Gung Memorial Hospital



50



POSTER SESSION

Abstract:
A 78-year-old male, diagnosed as B-cell lymphoma, Stage IIIA in Nov, 2010. The
pretreatment screening for hepatitis displayed HBsAg-negative, anti-HBs-positive, andanti-HBc-positive. From February of 2011, he received 5 cycles of R-CHOP andcompleted remission was achieved. In September of 2011, aminotransferase elevatedand Entecavir was strated under suspect of reactivation of HBV. In October,deterioration of renal function was noted and hemodialysis was administered. The
response to treatment was poor, ascites accumulation, hypotension, bradycardia
progressed and he expired in December of 2011 and autopsy was performed.
The autopsy showed diminished liver, 710g in weight, with cholestasis and wrinkled
surface. Microscopically, relatively marked dropout of hepatocytes replaced by diffuse
fibrosis representing P-P and P-C bridging and distortion of lobular architecture.
Conspicuous ballooning, microvesicular degeneration of hepatocytes, moderate
lymphocyte infiltration in portal areas, and severe cholestasis in bile canaliculi andhepatocyte. The findings in other organs included acute tubular necrosis of bilateralkidneys, hyperemic change with hyaline membrane formation of bilateral lungs,
enlargement of astrocytic nuclei (Alzheimer type II astrocytes) in cortex of cerebrum,consistent with hepatic encephalopathy. No recurrence of B-cell lymphoma was noted.
What happened to the patient? What is your diagnosis?

48

49

18:00-19:15

Poster: J-3
Title: Interobserver Agreement in the Nuclear Grading of Primary Pulmonary
Adenocarcinoma.
Presenter:٤ਛ㉿ቱᱜ Yosimasa Nakasato1) Yuko Minami2), Masayuki Noguchi2)
1) Department of Anatomic and Diagnostic Pathology; Dokkyo University
School of Medicine
2) Department of Pathology, Faculty of Medicine, University of Tsukuba
Moderator: Liang-Che Chang
Keelung Chang Gung Memorial Hospital‫ޣ‬Nuclear Grading Criteria‫ޤ‬
Negative cells

Positive cells

Nuclear area less than 5- fold smaller in Nuclear area more than 5-fold larger incomparison with lymphocytes
comparison with lymphocytes


52



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
53

POSTER SESSION

Abstract
Introduction: Nuclear grading involves an evaluation of the size and shape of nuclei andthe percentage of tumor cells in the mitotic phase. In the present study, we evaluatedthe interobserver variability of nuclear grading in primary pulmonary adenocarcinomas.
Methods: We analyzed 122 primary pulmonary adenocarcinomas, 2 cm or less indiameter. Eight pathologists independently evaluated the nuclear factors using thenuclear grading system (Nakazato Y. et al., Cancer, 2010) and we analyzed theinterobserver variability and compared the usefulness with other prognostic factors.
Results and Conclusion: The mean (±SD) kappa value for nuclear grading was 0.58+0.09
and the rate was highest among other factors including revised WHO and Noguchi’sclassification. The cases judged as negative on the basis of nuclear grading showed asignificantly better prognosis (5-year disease-free survival rate, 91.8%+2.7) than thepositive cases (68.6%+3.1). Nuclear grading is practical for prognostic evaluation of
pulmonary adenocarcinoma and highest of the interobserver agreement.

50

51

18:00-19:15

Poster: J-4
Title: A Case of Allergic Bronchopulmonary Mycosis (ABPM) caused by Schizophyllum
communePresenter:٤Takahashi Y1), Yonemori Y2), Ota S1), Toyoda Y3), Morimoto J3), Moriya Y3),
Toyotome T4), Watanabe A4), Kamei K4), Yoshino I3), Kawahara E5) and
Nakatani Y1, 2)
1) Department of Pathology, Chiba University Hospital2) Department of Diagnostic Pathology,3) Department of Thoracic Surgery, Graduate School of Medicine,
Chiba University
4) Division of Clinical Research, Medical Mycology Research Center,
Chiba University5) Institute of Medical, Pharmaceutical and Health Sciences,
Kanazawa University
Moderator: Yung-Hsiang Hsu
Buddhist Tzu-Chi General Hospital

54

POSTER SESSION

Abstract:
A 72-year-old female with a history of total gastrectomy and chemotherapy for gastriccancer had a complaint of cough, sputum and fever in 2011. Computed tomography
showed an irregular consolidation which was 70 mm in size in the middle lobe of theright lung. Bronchoscopy revealed a mucous plug in the right B5 bronchus. Sputum
culture grew Schizophyllum commune (S. commune). Analysis of her serum showedelevated IgE and IgG antibodies against the fungus. She was treated by itraconazole forabout 2 months, but the symptom did not improve. For the therapeutic purpose, middle
lobectomy of the right lung was performed. Gross examination showed multiple solid
lesions that were 7.0x3.5x2.0 cm in maximum size, slightly firm, relatively
well-circumscribed and tan in color. Microscopically, bronchial lumina were filled anddistended with mucous plugs of mucinous exudate, eosinophils and cellular debris with alayered pattern. Charcot-Leyden crystals were present in a background of mucus. Distal
bronchioles showed bronchocentric granulomatosis which displayed palisading
epithelial cells and central necrosis. The surrounding lung parenchyma showed areas ofeosinophilic pneumonia. Grocott staining showed small numbers of fragmented fungal
hyphae in mucous plugs without bronchial wall invasion. Based on the histopathologicalfindings, serological analysis and the culture result, we diagnosed the present case as
ABPM caused by S. commune. She had an uneventful postoperative course and is wellwith no recurrence of the disease 7 months after lobectomy.  S. commune usuallycolonizes rotten wood, bearing a basidiocarp (a fruiting body of a basidiomycete), and it
is distributed throughout the world. The fungus has rather uncharacteristic appearance,
and therefore has long been ignored as a contaminant. Due to the recent increase of theinfections, including ABPM, by this fungus, S. commune is presently recognized as an
emerging fungal pathogen. It is important to take into account the possibility of ABPM
caused by S. commune when Aspergillus species, the most common pathogen of ABPM,
are not isolated.

52

53

18:00-19:15

56

POSTER SESSION

Poster: J-5
Title: Molecular detection of micrometastasis in sentinel lymph nodes using One-Step
Nucleic acid Amplification assay for breast cancer patients- Comparison with routine pathological examination
Presenter:٤ᄢㄼᥓ Tomo Osako
Department of Pathology; The Cancer Institute Hospital of the JapaneseFoundation for Cancer Research
Moderator: Yung-Hsiang Hsu
Buddhist Tzu-Chi General Hospital
Abstract:
Background: Conventional histopathological examination is limited in measuring
accurate total metastatic volume in a lymph node. Recently, a molecular-based
procedure to detect lymph node metastases, one-step nucleic acid amplification (OSNA)
assay (Sysmex, Kobe, Japan), has been developed. The OSNA assay can assess an entire
lymph node and detect clinically relevant metastases quantified based on cytokeratin 19
mRNA copy number. We aimed to compare the performance of intraoperative detectionof sentinel node (SN) metastases with OSNA assay using a whole node and routine
frozen section (FS) histology using a 2-mm-sectioned node.
Methods: Subjects comprised 531 patients diagnosed with OSNA assay between 2009
and 2010, and 618 patients diagnosed with FS histology in 2008. We comparedSN-positive rate between the OSNA and FS cohorts. The cutoffs of the OSNA assay for
negative/positive and micro-/macrometastasis were set at 250 and 5,000 copies/µL,
respectively.
Results: OSNA assay detected more cases of SN metastases than FS histology (OSNA
121/531, 22.8% vs. FS 109/618, 17.6%; P=0.036), particularly micrometastases (46/531,
8.7% vs. 28/618, 4.5%; P=0.0064). There was no difference in macrometastasis detection
between OSNA and FS (75/531, 14.1% vs. 81/618, 13.1%; P=0.68).
Conclusion: Intraoperative OSNA assay detects more SN metastases, particularly
micrometastases, than routine FS histology. Follow up of the patients is required toclarify the prognosis of patients with micrometastasis using the OSNA assay, and as theresult, it may be possible to establish the new breast cancer staging system using OSNA
results.

54

55

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B Z シリーズだけの 基 本コンセプト
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正立・倒立の1台2役

安全・安心の作業環境

オールインワン設計

1台2役

ハイブリッドセルカウントで精度向上

筐体内部に暗室を設けることで、部屋本体一つに全てのシステムが内蔵され切片と培養細胞両方をこの一台でまか

キーエンス独自のアルゴリズムを用い、は明るいまま、他の作 業も同 時に行なており、使い方も簡単。
またレイアウトのなうことができ、結果色々な機器の操従 来ソフトで難しかった位 相 差 画 像えます。

変更も思いのままに行なえます。

作を覚えることや煩わしいメンテナンスかのセルカウントを実 現 。
もちろんオート

ら解放されます。

キャリブレーションで煩わしい作 業は観察効率の向上

A3サイズの設置面積でコンパクト

暗室を用意しにくい管理区域内にも設

手狭な場所でもわずかな面積で設置置ができるため、サンプルの近くで作業可能です。

必要ありません。

マクロセルカウントで時間短縮
一 回の調 整で、短 時 間かつ同 一 条

することができます。

汎用標本対応暗 室 不 要・省スペースと幅 広い観 察
標本対応を両立しています。

切片

件で複 数の画 像をカウントでき、大 幅

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な時 間の短 縮と精 度の向 上を両 立

高感度カメラを採用できます。

高感度カメラのため、蛍光観察時にサンプルの褪 色を低 減しつつ、鮮 明
な画像を表現。また、電動によるカラー
フィルタの挿入で、明視野観察もでき
マルチウェルプレート

ガラスボトムディッシュ

ます。

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