May 21 (Fri.)-May 22 (Sat.), 2021

The 1st Day : Friday, May 21

The 2nd Day : Saturday, May 22

Oral Presentation

Poster

9:00

Oral Presentation

9:00~10:25

Poster

9:00▶P.5

Session 4

Blood Stem Cell
O-8~O-12

10:00

Chair : Shigeru Chiba
Fumio Arai

10:00~11:30

幹細胞若手の会（つくしの会）

10:25~10:45

Chair : Sho Kubota
Michihiro Hashimoto

11:00

10:45~11:40

10:00

Coffee BreakSession 5

Tissue Stem Cell Ⅰ▶P.6

PosterViewing

11:00

O-13~O-15

Chair : Hironobu Fujiwara, Yusuke Ono
11:40~13:00

12:00

12:00~12:10
12:10~13:10

12:00

Opening Remarks

Lunch Time

Special Lecture
sponsered by BD
Kiyokazu Agata

13:00

Chair : Hiroyuki Kayo

13:10~13:40

Keynote Lecture Ⅰ▶P.3

Session 1▶P.3

13:00~13:05
13:05~14:35

Session 6

Takanori Takebe Chair : Ryuichi Nishinakamura
13:40~14:30

Organoid

14:00

O-16~O-19

15:00

14:50~15:40

Session 2

14:35~14:50

Session 3

Germline Stem Cell
O-5~O-7

O-20~O-22

PosterViewing

Chair : Atsushi Hirao
16:05~16:55

Chair : Shosei Yoshida
17:00

16:45~17:10
17:10~18:00

15:00

Cancer Stem Cell

O-3~O-4

16:00

▶P.8

Session 7

Chair : Hitoshi Niwa, Yasuhiro Yamada▶P.4

Coffee Break

14:50~16:05▶P.4

Reprogramming/Pluripotent Stem Cell
15:40~16:45

13:00

14:00

Chair : Kunimasa Ohta
Goro Sashida

Chair : Kosaku Nanki

Coffee Break▶P.7

Award Voting Due

Tissue Stem Cell Ⅱ

O-1~O-2

14:30~14:50

General Meeting

Keynote Lecture Ⅲ

▶P.8

16:00

Hideyuki Okano

Chair : Yukiko Gotoh

Coffee BreakKeynote Lecture Ⅱ▶P.4

16:55~17:05
17:05~17:10

Award Announcement
Closing Remarks

17:00

Hiroshi Hamada
Chair : Toshio Suda

18:00

18:00

19:00

19:00

20:00

20:00

18th Stem Cell Research Symposium

2

May 21 (Fri.)-May 22 (Sat.), 2021

The 1st Day
12:00～12:10

Opening Remarks

Organizer Hitoshi Takizawa(International Research Center for Medical Sciences, Kumamoto University)

12:10～13:10

Special Lecture

Chair Hiroyuki Kayo

(Nippon Becton Dickinson Company, Ltd., BD Life Sciences-Biosciences)SL

Purification and characterization of planarian adult Pluripotent StemCells (aPSC) by FACS
Kiyokazu Agata(National Institute for Basic Biology, Director General)

Sponsored by：Nippon Becton Dickinson Company

Chair Ryuichi Nishinakamura(Department of Kidney Development, IMEG, Kumamoto University)

KL-1 Modeling hepato-biliary-pancreatic organogenesis towards therapy
Takanori Takebe1,2

13:40～14:30

Session 1: Organoid

Chair Kosaku Nanki(Department of Organoid Medicine, Keio University School of Medicine)

Invited Lecture

O-01 Direct reprogramming to hepatic and intestinal lineages
Atsushi Suzuki(Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu
University)

Invited Lecture

O-02 Organoid-based analysis of human kidney development and disease
Ryuichi Nishinakamura(Department of Kidney Development, IMEG, Kumamoto University)

3

18th Stem Cell Research Symposium

Keynote Lecture Abstract / Oral (1st Day) Abstract / Oral (2nd Day) Abstract / Poster(1Division of Gastroenterology, Hepatology and Nutrition, Developmental Biology and Center
for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children’s Hospital Medical
Center, 2Institute of Research, Tokyo Medical and Dental University)

Special Lecture

13:10～13:40

Keynote Lecture Ⅰ

Program / 1st Day Program / 2nd Day Program / Poster

Friday, May 21.

Abstract / Poster Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Keynote Lecture

Special Lecture

Program / Poster Program / 2nd Day Program / 1st Day

May 21 (Fri.)-May 22 (Sat.), 2021

Coffee Break

14:30～14:50

Session 2: Reprogramming/Pluripotent Stem Cell

14:50～15:40

Chair Hitoshi Niwa

(Department of Pluripotent Stem Cell Biology, IMEG, Kumamoto University)

Yasuhiro Yamada(Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology,
Institute of Medical Science, University of Tokyo)

Invited Lecture

O-03 Context-dependent roles of NAT1 in stem cells
Kazutoshi Takahashi(Center for iPS cell Research and Application, Kyoto University)

Invited Lecture

O-04	Exploring the developmental regulation of 3D genome organization throughsingle-cell DNA replication profiling
Ichiro Hiratani(Laboratory for Developmental Epigenetics, RIKEN BDR, Kobe, Japan)

15:40～16:45

Session 3: Germline Stem Cell

Chair Shosei Yoshida(National Institute for Basic Biology, National Institutes of Natural Sciences)

Invited Lecture

O-05	Reconstitution of molecular and cellular networks regulating oocyte formation
Katsuhiko Hayashi(Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University)

Invited Lecture

O-06	Restoration of fertility by tuning the post-transplantation fate of mouse
spermatogonial stem cells
Yoshiaki Nakamura1, David Jörg2 , Benjamin Simons2 , Shosei Yoshida3(1Hiroshima University, 2University of Cambridge, 3National Institute for Basic Biology)

O-07 Multistate dynamics of stem cells in steady-state mouse spermatogenesis
Toshinori Nakagawa1, David Jorg2 , Ben Simons2 , Shosei Yoshida1(1National Institute for Basic Biology, 2University of Cambridge)

Coffee Break

16:45～17:10

Keynote Lecture Ⅱ

17:10～18:00

Chair Toshio Suda

(International Research Center for Medical Sciences, Kumamoto University)KL-2 Mechanism for left-right symmetry breaking:diversity among vertebrates
Hiroshi Hamada(RIKEN Center for Biosystems Dynamics Research)

18th Stem Cell Research Symposium

4

May 21 (Fri.)-May 22 (Sat.), 2021

The 2nd Day
9:00～10:25

Session 4: Blood Stem Cell

Chair Shigeru Chiba(Department of Hematology, Faculty of Medicine, University of Tsukuba)

Fumio Arai

(Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University)

Invited Lecture

O-08 Insights into the metabolic control of hematopoietic stem cell fateKeisuke Ito(Albert Einstein College of Medicine)(1Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center
for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan., 2Department ofBiochemistry Faculty of Medicine, Khon Kaen University, Thailand, 3Cancer Science Instituteof Singapore, National University of Singapore, Singapore, 4Institute of Resource Development
and Analysis, Kumamoto University, Kumamoto, Japan., 5Laboratory of Hematopoietic Stem
Cell Engineering, IRCMS , Kumamoto University, Kumamoto, Japan.)(1Laboratory of Stem Cell Stress, International Research Center for Medical Sciences(IRCMS), Kumamoto University, Japan, 2Division of Functional Structure, Department ofMorphological Biology, Fukuoka Dental College, Fukuoka, Japan, 3Intestinal Microbiota
Project, Kanagawa Institute of Industrial Science and Technology (KISTEC-KAST),
Kanagawa, Japan, 4Laboratory of Hematopoietic Stem Cell Engineering, International
Research Center for Medical Sciences (IRCMS), Kumamoto University, Japan, 5Graduate
School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology(KAIST), Daejeon, Republic of Korea, 6Graduate School of Nanoscience and Technology,
7
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Scienceand Technology (KAIST), Daejeon, Republic of Korea, 8Department of Gastroenterological
Surgery, Graduate School of Medical Sciences, 9Center for Metabolic Regulation of Healthy
Aging, Kumamoto University, Kumamoto, Japan, 10Institute for Advanced Biosciences (IAB),
Keio University, Yamagata, Japan, 11Transborder Medical Research Center, University ofTsukuba, Ibaraki, Japan, 12Laboratory of Stem Cell Stress, International Research Center for
Medical Sciences (IRCMS))

O-11 Group 2 innate lymphoid cells (ILC2s) support hematopoietic stem andprogenitor cell recovery under stress conditions
Takao Sudo1, Soichiro Hashimoto2 , Takafumi Yokota3 , Naoki Hosen3 , Masaru Ishii2(1Department of Hematology and Oncology/Immunology and Cell Biology, Graduate School of
Medicine, Osaka University, 2Department of Immunology and Cell Biology, Graduate Schoolof Medicine, Osaka University, 3Department of Hematology and Oncology, Graduate School of
Medicine, Osaka University)

5

18th Stem Cell Research Symposium

Keynote Lecture Abstract / Oral (1st Day) Abstract / Oral (2nd Day) Abstract / Poster

O-10 Hematopoietic stem and progenitor cells integrate microbial signals toenhance gut tissue repair
Maiko Sezaki1, Yoshikazu Hayashi2 , Gaku Nakato3 , Subinoy Biswas1,
Tatsuya Morishima4 , Jieun Moon5, Soyeon Ahn5, Pilhan Kim6,7, Yuji Miyamoto8,9,Hideo Baba 8,9, Shinji Fukuda3,10,11, Hitoshi Takizawa9,12Special Lecture

O-09 HMGA2 protects hematopoietic stem cell in stress hematopoiesis
Sho Kubota1, Yuqi Sun1, Jie Bai1, Takako Yokomizo-Nakano1, Mariko Morii1,
Supannika Sorin1,2 , Ai Hamashima1, Mihoko Iimori1, Motomi Osato3 , Kimi Araki4 ,Terumasa Umemoto5, Goro Sashida1

Program / 1st Day Program / 2nd Day Program / Poster

Saturday, May 22.

Abstract / Poster Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Keynote Lecture

Special Lecture

Program / Poster Program / 2nd Day Program / 1st Day

May 21 (Fri.)-May 22 (Sat.), 2021

O-12 Tracing the origin of hierarchical hematopoietic structure in fetal liver
Tomomasa Yokomizo1, Takako Ideue1, Mineo Kurokawa 2 , Norio Komatsu3 ,Kimi Araki4 , Motomi Osato1,5, Toshio Suda1,5(1IRCMS, Kumamoto University, 2Department of Hematology and Oncology, University ofTokyo, 3Department of Hematology, Juntendo University School of Medicine, 4Institute ofResource Development and Analysis, Kumamoto University, 5CSI, National University ofSingapore)

Coffee Break

10:25～10:45

Session 5: Tissue Stem Cell Ⅰ

10:45～11:40

Chair Hironobu Fujiwara(RIKEN Center for Biosystems Dynamics Research)

Yusuke Ono(Department of Muscle Development and Regeneration, IMEG, Kumamoto University)

Invited Lecture

O-13 Behaviors of muscle stem cells in overloaded muscle
So-ichiro Fukada(Graduate School of Pharmaceutical Sciences, Osaka University)

O-14 Nutrition-dependent de-differentiation of enteroendocrine cells ensures
adaptive growth in the adult Drosophila midgut
Yuichiro Nakajima1,2 , Erina Kuranaga 2 , Hiroki Nagai1(1FRIS, Tohoku University, 2Graduate School of Life Sciences, Tohoku University)

O-15 Airway tissue stem cells reutilize the embryonic proliferation regulator,
Tgfβ-Id2 axis, for tissue regeneration
Mitsuru Morimoto, Hirofumi Kiyokawa(RIKEN Center for Biosystems and Dynamics Research)

Lunch Time

11:40～13:00

General Meeting

13:00～13:05

Session 6: Tissue Stem Cell Ⅱ

13:05～14:35

Chair Kunimasa Ohta

(Department of Stem Cell Biology, Faculty of Arts and Science, Kyushu University)

Goro Sashida(Laboratory of Transcriptional Regulation in Leukemogenesis, International ResearchCenter for Medical Sciences (IRCMS), Kumamoto University)

Invited Lecture

O-16	A rtificially-induced neurogenesis and its therapeutic application to injury in
the adult central nervous systems
Kinichi Nakashima(Graduate School of Medical Sciences, Kyushu University)

Invited Lecture

O-17 Stem cell dynamics in skin regeneration and aging
Aiko Sada(International Research Center for Medical Sciences (IRCMS), Kumamoto University)

18th Stem Cell Research Symposium

6

May 21 (Fri.)-May 22 (Sat.), 2021

O-18 Origin and induction process of hair follicle stem cells
Ritsuko Morita1, Noriko Sanzen1, Hiroko Sasaki1, Tetsutaro Hayashi2 , Mana Umeda 2 ,Mika Yoshimura 2 , Takaki Yamamoto3,4 , Tatsuo Shibata3 , Takaya Abe5,
Hiroshi Kiyonari5, Yasuhide Furuta5,6 , Itoshi Nikaido2,7 and Hironobu Fujiwara1(1Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics
Research (BDR), Kobe, Japan, 2Laboratory for Bioinformatics Research, RIKEN Center for
Biosystems Dynamics Research (BDR), Kobe, Japan, 3Laboratory for Physical Biology, RIKEN
Center for Biosystems Dynamics Research (BDR), Kobe, Japan, 4Nonequilibrium Physics of
Living Matter RIKEN Hakubi Research Team, RIKEN Center for Biosystems Dynamics
Research (BDR), Kobe, Japan, 5Laboratory for Animal Resources and Genetic Engineering,
RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan, 6Mouse Genetics Core
Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, USA,
7
Bioinformatics Course, Master’s/Doctoral Program in Life Science, Innovation (T-LSI), Schoolof Integrative and Global Majors (SIGMA), University of Tsukuba, Wako, Saitama, Japan)(1Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental
University, Tokyo, Japan., 2Research Center for Medical and Dental Sciences, Tokyo Medical
and Dental University, Tokyo, Japan., 3Beppu Garden-Hill Clinic, Kurata Clinic, Beppu City,
Japan., 4Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department ofDevelopment and Stem Cells, CNRS UMR7104, Inserm U1258, Université de Strasbourg,
Illkirch, France., 5Department of Molecular Biology, Yokohama City University School of
Medicine, Kanazawa, Yokohama, Japan)

14:35～14:50

Session 7: Cancer Stem Cell

14:50～16:05

Chair Atsushi Hirao(Division of Molecular Genetics, Cancer Research Institute, Kanazawa University)

Invited Lecture

O-20	Epithelial Mesenchymal Transition (EMT) in developmental and cancer biology
Guojun SHENG, Sofiane HAMIDI, Hiroki NAGAI, Galym ISMAGULOV, Wei WENG
(International Research Center for Medical Sciences, Kumamoto University)

Invited Lecture

O-21 Somatic mutations in human ulcerative colitis epithelium
Kosaku Nanki1,2 , Toshiro Sato2(1Department of Gastroenterology, Keio University School of Medicine, 2Department ofOrganoid Medicine, Keio University School of Medicine)

Invited Lecture

O-22 Metabolic regulation of cancer cell fate in myeloid leukemia
Takahiro Ito(Institute for Frontier Life and Medical Sciences, Kyoto University)

7

18th Stem Cell Research Symposium

Keynote Lecture Abstract / Oral (1st Day) Abstract / Oral (2nd Day) Abstract / Poster

Coffee BreakSpecial Lecture

O-19 Distinct types of stem cell divisions determine organ regeneration and aging
in hair follicles
Hiroyuki Matsumura1, Nan Liu1, Daisuke Nanba1, Shizuko Ichinose2 , Aki Takada1,
Sotaro Kurata3 , Hironobu Morinaga1, Yasuaki Mohri1, Adèle De Arcangelis4 ,Shigeo Ohno5, Emi K. Nishimura1

Program / 1st Day Program / 2nd Day Program / Poster

Invited Lecture16:05～16:55

Keynote Lecture Ⅲ

Chair Yukiko Gotoh(Graduate School of Pharmaceutical Sciences, The University of Tokyo)

KL-3	Investigation of human neurological diseases using iPSCs and GM
Non-human Primates
Hideyuki Okano(Keio University School of Medicine)Award Announcement

16:55～17:05

Closing Remarks

17:05～17:10

Next Organizer

Yasuhiro Yamada

Abstract / Poster Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Keynote Lecture

Special Lecture

Program / Poster Program / 2nd Day Program / 1st Day

May 21 (Fri.)-May 22 (Sat.), 2021

18th Stem Cell Research Symposium

8

May 21 (Fri.)-May 22 (Sat.), 2021

Poster Session 1: Tissue Stem Cell
P-01 GFI1 Is a Downstream Target of EVI1 in Normal Hematopoiesis
Akira Chiba, Yosuke Masamoto, Hideaki Mizuno, Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine, The University ofTokyo)

P-02 Dysfunction of the proteoglycan Tsukushi causes hydrocephalus throughaltered neurogenesis in the subventricular zone in mice
Kunimasa Ohta1,2 , Shah Adil Ishtiyaq Ahmad2 , Naofumi Ito2
(1Kyushu University, 2Kumamoto University)(1Department of Life Science, Faculty of Medicine, Shimane University, 2PuREC Co., Ltd.)

P-04 Defining diversity and similarity of epithelial stem cell populations and theiranatomical environment in murine skin and oral mucosa
Yen Xuan Ngo1,2,3 , Hiroko Kato4 , Kenji Izumi4 , Hiromi Yanagisawa 2,5 , Aiko Sada 2,3

P-05 Biological effect of radiation exposure on clonal proliferation of mammary
stem cells using a lineage tracing technology
Daisuke Iizuka, Chizuru Tsuruoka, Mayumi Shinagawa, Masaaki Sunaoshi,
Tatsuhiko Imaoka, Shizuko Kakinuma(Department of Radiation Effects Research, National Institute of Radiological Sciences, QST)

P-06 Fanconi Anemia protein FANCD2 confers with Replication Stress through theHematopoietic Stem Cell expansion in Fetal Liver
Makiko Mochizuki-Kashio1, Yoon me Young2 , Theresa Menna3 , Markus Grompe4 ,Ayako Nakamura-Ishizu1, Peter Kurre3(1Department of Anatomy, Department of Medicine, Tokyo Women’s Medical University,
Tokyo, 2Committee on Immunology, Graduate Program in Biosciences, University of Chicago,
Chicago, 3Comprehensive Bone Marrow Failure Center, Children’s Hospital of Philadelphia;
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., 4Department ofPediatrics, Papé Family Pediatric Research Institute, Pediatric Blood & Cancer Biology
Program, Stem Cell Center, Oregon Health & Science University, Portland, OR.)918th Stem Cell Research Symposium

Keynote Lecture Abstract / Oral (1st Day) Abstract / Oral (2nd Day) Abstract / Poster(1Ph.D. Program in Human Biology, School of Integrative and Global Majors, University ofTsukuba, Tsukuba, Japan, 2Life Science Center for Survival Dynamics, Tsukuba Advanced
Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan, 3International ResearchCenter for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan, 4Graduate
School of Medical and Dental Sciences, Niigata University, Japan, 5Faculty of Medicine,
University of Tsukuba, Tsukuba, Japan)

Special Lecture

P-03 NRP2+ human mesenchymal stem cells have stemness-associated properties
Kotaro Tanaka1, Rintaro Yoshikawa1, Satoru Miyagi1, Takashi Suyama1,2 ,Hiromi Miyauchi1,2 , Yuko Kato1,2 , Ayako Watanabe1, Kenichi Miyamoto1,
Yumi Matsuzaki1,2Program / 1st Day Program / 2nd Day Program / Poster

Poster Session

Abstract / Poster Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Keynote Lecture

Special Lecture

Program / Poster Program / 2nd Day Program / 1st Day

May 21 (Fri.)-May 22 (Sat.), 2021

P-07 The metabolic fitness corresponding to chromatin accessibility patterns isessential for hematopoietic stem cell regulations
Terumasa Umemoto1, Alban Johansson1, Shah Adil Ishtiyaq Ahmad1,
Michihiro Hashimoto2 , Sho Kubota3 , Haruki Odaka4 , Takumi Era4 , Goro Sashida 3 ,Toshio Suda 2,5(1Laboratory of Hematopoietic Stem Cell Engineering, International Research Center for
Medical Sciences, Kumamoto University, 2Laboratory of Stem Cell Regulation, International
Research Center for Medical Sciences, Kumamoto University, 3Laboratory of Transcriptional
Regulation in Leukemogenesis, International Research Center for Medical Sciences,
Kumamoto University, 4Department of Cell Modulation, Institute of Molecular Embryology
and Genetics, Kumamoto University, 5Cancer Science Institute of Singapore, National
University of Singapore)

P-08 Environmental optimization to maintain the function of hematopoietic stem
cells after genome editing
Kohei Shiroshita1,2 , Hiroshi Kobayashi1, Keiyo Takubo1(1Department of Stem Cell Biology, Research Institute, National Center for Global Health andMedicine, 2Division of Hematology, Department of Internal Medicine, Keio University Schoolof Medicine)P-09 Characterization of Thpo-induced metabolic changes upon HSC induction toquiescence
Ayako Nakamura-Ishizu(Tokyo Women’s Medical University)

P-10 Dynamics of DNA double-strand break repair of stem and mature cells in rat
mammary gland
Kento Nagata1, Yukiko Nishimura1, Yuya Hattori2 , Ritsuko Watanabe3 , Keiji Suzuki4 ,Shizuko Kakinuma1, Tatsuhiko Imaoka1(1Department of Radiation Effects Research, National Institute of Radiological Sciences,
National Institutes for Quantum and Radiological Science and Technology, 2Department of
Systems and Control Engineering, School of Engineering, Tokyo Institute of Technology,
3
Institute for Quantum Life Science, National Institutes for Quantum and Radiological Scienceand Technology, 4Department of Radiation Medical Sciences, Atomic Bomb Disease Institute,
Nagasaki University)

P-11 The chromatin remodeling factor BRM maintains the hematopoietic stem cellquiescence via repression of inflammatory stress signaling
Eriko Nitta1, Hiroki Kiriyama1, Hiroki Miyachi1, Nonoko Kawabata1,
Tsuyoshi Imasaki1, Naoki Itokawa 2 , Shuhei Koide2 , Masayuki Yamashita 2 ,Motohiko Oshima 2 , Toshio Suda 3 , Atsushi Iwama 2 , Ryo Nitta1(1Kobe University Graduate School of Medicine, 2Institute of Medical Science, University ofTokyo, 3Cancer Science Institute of Singapore, National Institute of Singapore)

P-12 Melanocyte stem cell dynamics underlie de novo melanomagenesis
Sally Eshiba1, Takeshi Namiki2 , Yasuaki Mohri1, Naotaka Serizawa1,
Takakazu Shibata3 , Hironobu Morinaga1, Daisuke Nanba1, Keiko Miura4 ,Masaru Tanaka5, Hisashi Uhara6 , Hiroo Yokozeki2 , Toshiaki Saida7,
Emi K. Nishimura1(1Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental
University, Japan, 2Department of Dermatology, Medical Research Institute, Tokyo Medical
and Dental University, Japan, 3Medical Corporation Shibata Dermatology Clinic, Japan,
4
Department of Pathology, Medical Research Institute, Tokyo Medical and Dental University,
Japan, 5Department of Dermatology, Tokyo Women's Medical University Medical Center East,
Tokyo, Japan, 6Department of Dermatology, Sapporo Medical University School of Medicine,
Sapporo, Japan, 7Shinshu University, Matsumoto, Japan)

18th Stem Cell Research Symposium

10

May 21 (Fri.)-May 22 (Sat.), 2021

(Graduate School of Pharmaceutical Sciences, The University of Tokyo)

P-14 Low dose-rate irradiation preferentially damages mitochondrial function of
the more undifferentiated hematopoietic cells
Yoshinori Ohno1, Kyoko Suzuki-Takedachi2 , Yun Guo3 , Naoto Shirasu1,
Motoaki Ohtsubo4 , Yoshihiro Takihara 2,5 , Shin’ichiro Yasunaga1(1Dept. Biochem., Facul. Med., Fukuoka Univ., 2Dept. Stem Cell Biol., RIRBM, Hiroshima Univ.,
3
Dept. Immunol., Grad. Sch. Biomed. Sci., Hiroshima Univ., 4Dept. Food and Ferment. Sci.,
Beppu Univ., 5Japanese Red Cross Kinki Block Blood Center.)

P-15 Dynamic changes in the chromatin accessibility during neuronal differentiation
Yusuke Kishi, Seishin Sakai, Merve Bilgic, Yukiko Gotoh(Graduate School of Pharmaceutical Sciences, The University of Tokyo)

Poster Session 2: Multi-/pluri-potent Stem Cell (iPS/ES)(Department of Regenerative Medicine and Theraputics, Graduate School of Medical Science,
Tottori University)(1IMEG, Kumamoto University, 2RIKEN IMS)

P-18 PRC1.6-dependent and –independent repression of meiosis-related genes by
MGA with its sophisticated use of two distinct DNA binding domains
Kousuke Uranishi, Yuka Kitamura, Ayumu Suzuki, Masataka Hirasaki,
Masazumi Nishimoto, Akihiko Okuda(Saitama Medical University)

P-19 Polycomb repressive complex 2 coordinates total glycome dynamics during themouse naïve-to-primed pluripotency state transition
Hayato Ota1, Federico Pecori1, Ikuko Yokota 2 , Hisatoshi Hanamatsu2 , Taichi Miura3 ,Chika Ogura1, Jun-ichi Furukawa 2 , Shinya Oki4 , Kazuo Yamamoto5, Osamu Yoshie6 ,Shoko Nishihara1(1Department of Bioinformatics, Graduate School of Engineering, Soka University,2
Department of Advanced clinical glycobiology, Faculty of Medicine and Graduate School of
Medicine, Hokkaido University, 3National Institute of Radiological Sciences (NIRS), National
Institutes for Quantum and Radiological Science and Technology, 4Department of Drug
Discovery Medicine, Graduate School of Medicine, Kyoto University, 5Department ofIntegrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo,
6
Health and Kampo Institute)

11

18th Stem Cell Research Symposium

Keynote Lecture Abstract / Oral (1st Day) Abstract / Oral (2nd Day) Abstract / Poster

P-17 Role of PRC1.6 Polycomb complex for repression of ZGA- and germline-related
genes in pluripotent stem cells
Mitsuhiro Endoh1, Haruhiko Koseki2 , Hitoshi Niwa1

Special Lecture

P-16 An investigation of human cardiac pacemaker cells differentiation processusing human induced pluripotent stem cells visualizing HCN4/Shox2 gene
expression
Takayuki Wakimizu, Motokazu Tsuneto, Yasuaki Shirayoshi, Ichiro Hisatome

Program / 1st Day Program / 2nd Day Program / Poster

P-13 BMP signaling suppresses Gemc1 expression and ependymal differentiation ofmouse telencephalic progenitors
Hanae Omiya, Shima Yamaguchi, Tomoyuki Watanabe, Kuniya Takaaki,
Yujin Harada, Daichi Kawaguchi, Yukiko GotohAbstract / Poster Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Keynote Lecture

Special Lecture

Program / Poster Program / 2nd Day Program / 1st Day

May 21 (Fri.)-May 22 (Sat.), 2021

P-20 Mucin-type O-glycosylation regulates the pluripotency of mouse embryonicstem cells via Wnt receptor endocytosis
Miki Mori1, Federico Pecori2 , Yoshihiro Akimoto3 , Jun-ichi Furukawa4 ,Yasuro Shinohara5, Yuzuru Ikehara6 , Shoko Nishihara7(1Department of Life Sciences, Graduate School of Science and Engineering, Soka University,
2
Laboratory of Cell Biology, Department of Bioinformatics, Graduate School of Engineering,Soka University, 3Department of Anatomy, Kyorin University School of Medicine,
4
Department of Advanced clinical glycobiology, Faculty of Medicine and Graduate School of
Medicine, Hokkaido University, 5Department of Pharmacy, Kinjo Gakuin University,
6
Department of Molecular and Tumor Pathology, Graduate School of Medicine, Chiba
University, 7Glycan & Life System Integration Center (GaLSIC), Faculty of Science andEngineering, Soka University)

P-21 Max regulates the transition from mitosis to meiosis in mouse ESCs and PGCs
Ayumu Suzuki1, Kousuke Uranishi1, Yuka Kitamura1, Masazumi Nishimoto2 ,Akihiko Okuda1(1Research Center for Genomic Medicine, Saitama Medical University, 2Biomedical ResearchCenter, Saitama Medical University)

Poster Session 3: Cancer Stem Cell
P-22 Polymer-based elucidation of molecular basis underlying
cancer stem cell-mediated niche reconstruction and glioma recurrence
Kouichi Tabu, Tetsuya Taga

(Department of Stem cell regulation, Medical Research Institute, Tokyo Medical and Dental
University (TMDU))

P-23 miR-93 targets WASF3 and functions as a metastasis suppressor in humanbreast cancer stem cells
Yohei Shimono1,2 , Naoki Shibuya 2 , Tatsunori Nishimura3 , Noriko Gotoh3 ,Yoshihiro Kakeji2(1Fujita Health University, 2Kobe University Graduate School of Medicine, 3Cancer ResearchInstitute, Kanazawa University)

P-24 Niche-mimicking polymer-based characterization of human pancreatic cancer
stem cells
Mariko Nagane1, Kouichi Tabu1, Yoshitaka Murota1, Shinji Tanaka 2 , Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental
University, 2Department of Molecular Oncology, Graduate school of Medical and Dental
Sciences, Tokyo Medical and Dental University)

P-25 Effect of ionizing radiation on balance between basal and luminal cell
populations in rat mammary epithelium
Tatsuhiko Imaoka1, Ken-ichi Kudo2 , Yukiko Nishimura1, Keiji Suzuki3 , Kento Nagata1,
Mayumi Nishimura1, Kazuhiro Daino1, Shizuko Kakinuma1(1National Institutes for Quantum and Radiological Science and Technology, 2Fukushima
Medical University, 3Nagasaki University)

P-26 Age-dependent thymus regeneration by activation of PI3K-AKT-mTOR
pathway in B6C3F1 mice during thymic lymphomagenesis after irradiation
Masaaki Sunaoshi1, Benjamin J. Blyth2 , Yi Shang1, Chizuru Tsuruoka1,
Takamitsu Morioka1, Mayumi Shinagawa1, Mari Ogawa1, Yoshiya Shimada 3 ,Akira Tachibana4 , Daisuke Iizuka1, Shizuko Kakinuma1(1Radiat. Effects Res., Nat. Inst. Radiol. Sci., QST, 2Cancer Res. Div., Peter MacCallum Cancer
Centre, 3Inst. Environ. Sci., 4Grad. Sch. Sci. Eng., Ibaraki Univ.)

18th Stem Cell Research Symposium

12

May 21 (Fri.)-May 22 (Sat.), 2021

(The University of Tokyo, The Institute of Medical Science)

P-28 A mechanism of oncogenic self-renewal mediated by MLL and MOZ complexes
Akihiko Yokoyama(National Cancer Center Tsuruoka Metabolomics Laboratory)

Poster Session 4: Microenvironment
P-29 A novel YAP/TAZ activator restores bone marrow microenvironment andpromotes hematopoietic regeneration
Shun Uemura1, Masayuki Yamashita1, Ayako Aihara 2 , Taito Nishino2 ,Atsushi Iwama1(1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology andRegenerative Medicine, The Institute of Medical Science, The University of Tokyo, 2BiologicalResearch Laboratories, Nissan Chemical Corporation)(1Department of Stem Cell Biology, National Center for Global Health and Medicine ResearchInstitute, Japan, 2Division of Hematology, Keio University School of Medicine, 3Division of
Biochemistry, Keio University School of Medicine, 4Laboratory of Stem Cell Stress, IRCMS,
Kumamoto University, Kumamoto, Japan, 5Division of Hematology, Keio university School of
Medicine)(1Laboratory of Stem Cell Stress, International Research Center for Medical Sciences,
Kumamoto University, 2Laboratory of Stem Cell Engineering, International Research Center
for Medical Sciences, Kumamoto University, 3Intestinal Microbiota Project, Kanagawa
Institute of Industrial Science and Technology (KISTEC-KAST), 4Institute for Advanced
Biosciences (IAB), Keio University, 5Transborder Medical Research Center, University ofTsukuba)

P-32 CD271+CD51+ human mesenchymal stem/stromal cells possess enhanced
chondrogenic potential towards humanized ossicle generation
Maiko Sezaki1, Subinoy Biswas1, Pui-Yu Ho1, Shuhei Koide2 , Takeshi Miyamoto3 ,Atsushi Iwama 2 , Hitoshi Takizawa1(1International Research Center for Medical Sciences, Kumamoto University, Kumamoto,Japan, 2The Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan,
3
Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University,
Kumamoto, Japan)

P-33 Nitric oxide-dependent vasodilation maintains physiological hypoxia and local
crawling of hematopoietic stem cell in bone marrow
Takayuki Morikawa1, Shinya Fujita1,2 , Toshitada Yoshihara 3 , Reiko Sakaguchi4 ,Yasuo Mori4 , Seiji Tobita3 , Keiyo Takubo1(1Department of Stem Cell Biology, Research Institute, National Center for Global Health andMedicine, 2Division of Hematology, Keio University School of Medicine, 3Graduate School of
Science and Technology, Gunma University, 4Laboratory of Molecular Biology, Department ofSynthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto
University)

13

18th Stem Cell Research Symposium

Keynote Lecture Abstract / Oral (1st Day) Abstract / Oral (2nd Day) Abstract / Poster

P-31 Akkermansia Muciniphila induces long-term sustained extramedullary
hematopoiesis
Yuxin Wang1, Tatsuya Morishima1,2 , Gaku Nakato3 , Shinji Fukuda3,4,5 ,Hitoshi Takizawa1

Special Lecture

P-30 Non-neuronal acetylcholine in the bone marrow regulates B cell differentiation
Shinya Fujita1,2 , Takayuki Morikawa1, Yuki Sugiura3 , Takako Hishiki3 , Maiko Sezaki4 ,Hitoshi Takizawa4 , Keisuke Kataoka5, Makoto Suematsu3 , Keiyo Takubo1

Program / 1st Day Program / 2nd Day Program / Poster

P-27 IRAK1/4-NFkB-PD-L1 axis is crucial for imatinib-insensitivity of CML LSCs
Yosuke Tanaka, Susumu Goyama, Toshio Kitamura

Abstract / Poster Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Keynote Lecture

Special Lecture

Program / Poster Program / 2nd Day Program / 1st Day

May 21 (Fri.)-May 22 (Sat.), 2021

P-34 The membrane-linked adaptor FRS2b fashions a cytokine-rich inflammatory
microenvironment that promotes breast cancer carcinogenesis
Yasuto Takeuchi1, Natsuko Kimura 2 , Takahiko Murayama1, Yukino Machida 2 ,Daisuke Iejima 2 , Tatsunori Nishimura1, Reiko Sakamoto3 , Mizuki Yamamoto4 ,Naoki Itano5, Yusuke Inoue6 , Masataka Ito7, Nobuaki Yoshida3 , Jun-ichiro Inoue4 ,Kouichi Akashi8 , Hideyuki Saya9, Koji Fujita10, Masahiko Kuroda10,
Issay Kitabayashi11, Arinobu Tojo2 , Noriko Gotoh1(1Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kakumamachi, Kanazawa, Japan, 2Division of Molecular Therapy, Institute of Medical Science,
University of Tokyo, Minato-ku, Tokyo, Japan, 3Laboratory of Developmental Genetics,
Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan, 4Division of
Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Minato-ku,
Tokyo, Japan, 5Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo
University, Kita-ku, Kyoto, Japan, 6Department of Diagnostic Radiology, Kitasato University of
School of Medicine, Sagamihara city, Kanagawa, Japan, 7Department of Anatomy, National
Defense Medical College, Tokorozawa, Japan, 8Department of Medicine and Biosystemic
Science, Graduate School of Medicine, Kyushu University, Fukuoka, Japan, 9Division of Gene
Regulation, Insitute of Advanced Medical Research, Keio University, Shinjuku, Tokyo, Japan,
10
Department of Molecular Pathology, Tokyo Medical University, Shinjuku, Tokyo, Japan,
11
Division of Hematological Malignancy, National Cancer Center Research Institute, Chuo- ku,
Tokyo, Japan)

Poster Session 5: Organoid
P-35 Epithelial expression of Gata4 and Sox2 regulates specification of thesquamous–columnar junction via MAPK/ERK signaling in murine stomach
Nao Sankoda1, Yoshiya Kawaguchi2 , Yasuhiro Yamada1(1Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology,
Institute of Medical Science, University of Tokyo, 2Department of Life Science Frontiers,
Center for iPS Cell Research and Application (CiRA), Kyoto University)

P-36 Conceptual basis of lineage shift between intestinal epithelium and hepatocytes
Sakurako Kobayashi1, Satoshi Watanabe1, Nobuhiko Ogasawara1, Yosuke Yoneyama 2 ,Ryu Nishimura1, Sayaka Nagata1, Masami Inoue3 , Kouhei Suzuki1, Go Ito4 ,Hiromichi Shimizu3 , Tomohiro Mizutani1, Yoshihito Kano5, Shigeru Oshima1,
Sei Kakinuma6 , Kiichiro Tsuchiya1, Ryuichi Okamoto1, Mamoru Watanabe4 ,Takanori Takebe2,7, Shiro Yui3

(1Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology,
2
Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research,
3
Tokyo Medical and Dental University, Center for Stem Cells and Regeneration Medicine,4Tokyo Medical and Dental University, Advanced Research Institute (IBD Lab), 5Tokyo
Medical and Dental University, Department of Precision Cancer Medicine, Graduate School,
Center for Innovative Cancer Treatment, 6Tokyo Medical and Dental University, Departmentof Clinical and Diagnostic Laboratory Science, 7Cincinnati Children’s Hospital Medical Center,
Division of Gastroenterology, Hepatology & Nutrition, Developmental Biology, Center for Stem
Cell and Organoid Medicine (CuSTOM))

P-37 Generation of allogenic iPSC-derived three-dimensional retinal sheet for
first-in-human clinical research
Atsushi Kuwahara1, Suguru Yamasaki1, Kenji Watari1, Tetsuya Hayama1,
Tatsuya Kamei1, Aya Nakamura 2 , Kazuki Ueyama 2 , Keiichi Ono2 , Osamu Ohno1,
Yasuyuki Kita1, Orie Terai1, Masayo Fujiwara1, Yoriko Hori1, Anna Tanabe1,
Rina Hirai1, Hidetaka Ohara3 , Keigo Kawabe3 , Atsushi Ikeda1, Akiyoshi Kishino1,
Michiko Mandai4 , Toru Kimura1(1Regenerative & Cellular Medicine Kobe Center, Sumitomo Dainippon Pharma Co., Ltd.,
2
Technology Research & Development Division, Sumitomo Dainippon Pharma Co., Ltd.,
3
Regenerative & Cellular Medicine Office, Sumitomo Dainippon Pharma Co., Ltd., 4Laboratory
for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research)

18th Stem Cell Research Symposium

14

May 21 (Fri.)-May 22 (Sat.), 2021

P-39 Taurine Modification of Mitochondrial tRNAs is Indispensable for Fetal
Erythroid Differentiation
Md Fakruddin1, Vivien Schoonenberg2 , Falk Butter2 , Yuichiro Arima 3,4 ,Tatsuya Morishima1, Kenichi Tsujita4 , Hitoshi Takizawa1

Program / 1st Day Program / 2nd Day Program / Poster

P-40 演題取り下げ

Special Lecture

Poster Session 6: Other
P-38 Phospholipid metabolism adaptation induces drug resistance in IDH mutant
AML cells
Tatsuya Morishima1,2 , Koichi Takahashi3 , Desmond Chin4 , Kenji Tokunaga5,
Masao Matsuoka5, Toshio Suda6,7, Hitoshi Takizawa1(1Laboratory of Stem Cell Stress, International Research Center for Medical Sciences,
Kumamoto University, 2Laboratory of Hematopoietic Stem Cell Engineering, International
Research Center for Medical Sciences, Kumamoto University, 3Department of Leukemia andDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center,
4
Genome Institute of Singapore, 5Department of Haematology, Rheumatology, and Infectious
Diseases, Kumamoto University School of Medicine, 6Laboratory of Stem Cell Regulation,
International Research Center for Medical Sciences, Kumamoto University, 7Cancer Science
Institute of Singapore, National University of Singapore)(1Laboratory of Stem Cell Stress, International Research Center for Medical Sciences(IRCMS), Kumamoto University, Kumamoto, Japan, 2Institute of Molecular Biology, Mainz,
Germany, 3Laboratory of Developmental Cardiology, International Research Center for
Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan, 4Department of
Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University,
Kumamoto, Japan)(Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology,
Institute of Medical Science, The University of Tokyo)

P-42 Midazolam anesthesia modifies chromatin landscape to promote neural stem
cell dormancy
Hiroyoshi Doi1,2 , Taito Matsuda1, Kinichi Nakashima1(1Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University, 2Department of Anesthesiology and Critical Care Medicine, Graduate
School of Medical Sciences, Kyushu University)

P-43 Germ cell specific Mga splicing variant might function as a fail-safe in meiotic
process
Yuka Kitamura, Kousuke Uranishi, Masataka Hirasaki, Masazumi Nishimoto,
Ayumu Suzuki, Akihiko Okuda(Saitama Medical University)

P-44 Laminin-derived recombinant fragment facilitates isolation and proliferationof skeletal myoblast from various animal species
Yuki Kihara1,2 , Ryo Takagi2 , Satoru Nagata1, Masayuki Yamato2(1Department of Pediatrics, Tokyo Women’s Medical University, 2Institute of Advanced
BioMedical Engineering, Tokyo Women’s Medical University)

15

18th Stem Cell Research Symposium

Keynote Lecture Abstract / Oral (1st Day) Abstract / Oral (2nd Day) Abstract / Poster

P-41 The expansion of pancreatic insulin-producing cells for the amelioration ofdiabetic mellitus
Michitada Hirano, Yusei So, Yasuhiro YamadaP-45 Transcriptional corepressor-mediated regulation in human pluripotent stem
cells
Yusuke Tarumoto1, Katarzyna Tilgner2 , Bahar Mirshekar2 , Yoshie Masuda1,
Seiichi Sugino1, Kosuke Yusa1,2(1Institute for Frontier Life and Medical Sciences, Kyoto University, 2Wellcome Sanger
Institute, UK)

P-46 Blastocyst complementation using Prdm14-deficient rats for robust germline
transmission
Toshihiro Kobayashi1,2,3 , Teppei Goto1, Mami Oikawa1,3 , Makoto Sanbo1,
Yasuhiro Kazuki4,5, Hiromitsu Nakauchi6,7, Azim M Surani8,9, Masumi Hirabayashi1,2(1Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, 2The
Graduate University of Advanced Studies, 3Division of Mammalian Embryology, Institute ofMedical Science, The University of Tokyo, 4 Department of Biomedical Science, Institute ofRegenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori
University, 5Chromosome Engineering Research Center, Tottori University, 6 Division of Stem
Cell Therapy, Institute of Medical Science, The University of Tokyo, 7Institute for Stem Cell
Biology and Regenerative Medicine, Department of Genetics, Stanford University School of
Medicine, 8Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge,
9
Department of Physiology, Development and Neuroscience)

Abstract / Poster Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Keynote Lecture

Special Lecture

Program / Poster Program / 2nd Day Program / 1st Day

May 21 (Fri.)-May 22 (Sat.), 2021

18th Stem Cell Research Symposium

16