May 26 (Fri)-May 27 (Sat), 2017

8:00

The 1st Day : Friday, May 26
B2F HALLThe 2nd Day : Saturday, May 27
B2F HALL

8:00

9:00

9:00

9:30~11:30

9:30~10:40

3F 中教室Session 3▶P.5

Pluripotent Stem Cells and Patient-derived iPSC

10:00

O-8~O-11

幹細胞若手の会（つくしの会）

10:00

Chair : Koji Eto
10:40~10:55

11:00

Coffee Break

10:55~12:30

▶P.5

11:00

Session 4

Cancer Stem Cells
O-12~O-16

Chair : Issay Kitabayashi
Noriko Gotoh

12:00

12:00

12:30~14:00

13:00

13:00~13:10
13:10~14:15

Opening Remarks
Session 1

13:00

Lunch Time / Poster Session▶P.3

Tissue Stem Cells (I)O-1~O-3

14:00

Chair : Fumio Arai
14:15~14:30

Session 2▶P.3

Reprogramming and Pluripotent Stem Cells

O-17~O-22

O-4~O-7

15:50~16:05
16:05~17:35

Coffee BreakSpecial Lecture

15:00

Chair : Atsushi Hirao
Kunimasa Ohta

16:05~▶P.4

S-1 Takashi Shinohara
S-2 Emi K. Nishimura
S-3 Yasuyuki Fujita

17:00

14:00

Session 5

Tissue Stem Cells (II)

Chair : Hitoshi Niwa
Takumi Era
16:00

▶P.6

Coffee Break

14:30~15:50

15:00

14:00~16:05

Closing Remarks

16:00

17:00

Chair : Atsushi Iwama
17:35~17:50

18:00

19:00

General Meeting
18:00

18:00~

Reception

19:00

20:00

20:00

15th Stem Cell Research Symposium

2

May 26 (Fri)-May 27 (Sat), 2017

The 1st Day
13:00～13:10

Opening Remarks Organizer Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba
University)

13:10～14:15

Session 1: Tissue Stem Cells (I)Chair Fumio Arai

(Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University)(Project Division of Advanced Regenerative Medicine, The Institute of Medical
Science, the University of Tokyo)(1Department of Molecular Genetics, Princess Margaret Cancer Centre, University
Health Network, Toronto, 2Department of Innovation Therapy, Chiba University
Graduate School of Medicine, Chiba, 3Department of Medicine, University ofToronto, 4Department of Medical Biophysics, University of Toronto, 5Ontario
Institute for Cancer Research, Toronto, 6Authors equally contributed to this work)O-3 27-hydroxycholesterol induces hematopoietic stem cell mobilization andextramedullary hematopoiesis during pregnancy
Hideyuki Oguro1, Sean Morrison2(1Cellular Engineering, The Jackson Laboratory for Genomic Medicine, 2Children’s
Research Institute, Howard Hughes Medical Institute, University of Texas
Southwestern Medical Center)

14:15～14:30

Coffee BreakSession 2: Reprogramming and Pluripotent Stem Cells

14:30～15:50

Chair Hitoshi Niwa

(Institute of Molecular Embryology and Genetics, Kumamoto University)

Takumi Era

O-4 In vitro reprogramming of mature hepatocytes to culturable liver progenitor
cells using small molecules
Takeshi Katsuda, Masaki Kawamata, Keitaro Hagiwara,
Ryou-u Takahashi, Yusuke Yamamoto, Kazunori Hosaka, Takahiro Ochiya(National Cancer Center Research Institute)3

15th Stem Cell Research Symposium

Abstract / Poster(Department of Cell Modulation, Institute of Molecular Embryology and Genetics,
Kumamoto University)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-2 Chromatin accessibility identifies CTCF as a gatekeeper of stemness functions
in human hematopoietic development
Naoya Takayama1,2,6 , Alex Murison1,6 , Shin-ichiro Takayanagi1,
Sasan Zandi1, Nadia Penrod1, Amanda Mitchell1, James Kennedy1,
Stanley Ng1, Stephanie Xie1, Mark Minden3 , John E. Dick1,
and Mathieu Lupien1,4,5

Program / Poster

O-1 Valine starving permits hematopoietic stem cell transplantation without
chemoirradiative myeloablation
Satoshi Yamazaki

Program / 1st Day Program / 2nd Day

Friday, May 26.

May 26 (Fri)-May 27 (Sat), 2017

O-5 Srf destabilizes cellular identity by suppressing cell-type-specific gene
expression programs
Shinji Masui, Takashi Ikeda, Akitsu Hotta(Department of Life Science Frontiers, CiRA, Kyoto University)

O-6 Generation of adult-like cardiomyocytes from pluripotent stem cells in vivo
Hideki Uosaki1, Nawin Chanthra1, Yasumitsu Nagao1, Gunsik Cho2 ,Chulan Kwon2 , Yutaka Hanazono1(1Jichi Medical University, 2Johns Hopkins University)

O-7 Creation of eggs in a dish as a model and a resource
Katsuhiko Hayashi(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)

Coffee Break

15:50～16:05

Special Lecture

16:05～17:35

Chair Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba
University)

S-1 Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell selfrenewal

Takashi Shinohara(Kyoto University)

S-2 Stem cells orchestrates hair follicle aging program
Emi K. Nishimura(Dept. Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental
University)

S-3 Cell competition between normal and transformed epithelial cells
Yasuyuki Fujita(Hokkaido University, Institute for Genetic Medicine, Division of Molecular
Oncology)

17:35～17:50

General Meeting

Chief Director

Koichi Akashi(Department of Medicine and Biosystemic Science, Faculty of Medicine, Kyushu
University)

18:00～

Reception

15th Stem Cell Research Symposium

4

May 26 (Fri)-May 27 (Sat), 2017

The 2nd Day

Session 3: Pluripotent Stem Cells and Patient-derived iPSC

9:30～10:40

Chair Koji Eto(Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto
University)

O-8 Regulating the mesoderm patterning generates kidney organoids from humanpluripotent stem cells
Minoru Takasato(RIKEN CDB)

(1Department of Dentistry and Oral Surgery, Keio University School of Medicine,2
Department of Physiology, Keio University School of Medicine, 3Department ofOrthopedic Surgery, Keio University School of Medicine)(1Department of Pediatrics, Perinatal Medical Center, Kumamoto University
Hospital, 2Department of Cell Modulation, Division of Stem Cell Research, Instituteof Molecular Embryology and Genetics, Kumamoto University, 3Department ofPediatrics, Developmental and Reconstructive Medical Sciences, Division ofAdvanced Biomedical Sciences, Faculty of Life Sciences Kumamoto University)

O-11 Patient-derived induced pluripotent stem cells identify ADAM8 (CD156) as anovel antigen of TKI-resistant chronic myeloid leukemia cells
Masashi Miyauchi, Junji Koya, Shunya Arai, Sho Yamazaki, Akira Honda,
Keisuke Kataoka, Akihide Yoshimi, Kazuki Taoka, Keiki Kumano,
Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine, The
University of Tokyo)

Coffee Break

10:40～10:55

Session 4: Cancer Stem Cells

10:55～12:30

Chair Issay Kitabayashi(Division of Hematological Malignancy, National Cancer Center Research Institute)

Noriko Gotoh(Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University)(Division of Gene Regulation, Institute for Advanced Medical Research (IAMR),
School of Medicine, Keio University)

5

15th Stem Cell Research Symposium

Abstract / Poster

O-12 Therapeutic targeting of amino acid transport system xc(-) in
CD44v-expressing stem-like cancer cells
Osamu Nagano

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-10 Target specific drug screening using patient-derived induced pluripotent stem
cell for methylmaronic acidemia
Shirou Matsumoto1, Tadahiro Numakawa 2 , Fumio Endo3 , Takumi Era 2

Program / Poster

O-9 LNGFR(+)THY-1(+) multipotent stem cells derived from human induced
pluripotent stem cells
Takehito Ouchi1,2 , Shinsuke Shibata 2 , Hiroo Kimura3 , Masaya Nakamura3 ,Taneaki Nakagawa1, Hideyuki Okano2

Program / 1st Day Program / 2nd Day

Saturday, May 27.

Program / Poster

Program / 2nd Day Program / 1st Day

May 26 (Fri)-May 27 (Sat), 2017

O-13 Maintenance of stemness and niche environment of breast cancer cells by
FRS2beta, a feedback inhibitor for HER2-ERK pathway, during mammary
tumorigenesis
Natsuko Kimura1, Yukino Machida 2 , Keiichiro Tada 3 , Jun-ichiro Inoue4 ,Issay Kitabayashi2 , Arinobu Tojo1, Noriko Gotoh5(1Division of Molecular Therapy, Institute of Medical Science, University of Tokyo,
2
Division of Hematological Malignancy, National Cancer Center Research Institute,3
Department of Breast and Endocrine Surgery, The University of Tokyo Hospital,
4
Division of Cellular Molecular and Biology, Institute of Medical Science,
University of Tokyo, 5Division of Cancer Cell Biology, Cancer Research Institute,
Kanazawa University)

O-14 Coordinated action of miRNAs for the regulation of normal and colon cancer
stem cells
Yohei Shimono1, Shigeo Hisamori2 , Piero Dalerba3 , Junko Mukohyama1,
Taichi Isobe4 , Hironobu Minami5, Akira Suzuki1(1Division of Molecular and Cellular Biology, Kobe University Graduate School of
Medicine, 2Department of Surgery, Kyoto University Hospital, 3Department of
Pathology and Cell Biology, Columbia University, 4Institute for Stem Cell Biology
and Regenerative Medicine, Stanford University, 5Division of Oncology/
Hematology, Kobe University Graduate School of Medicine)

O-15 Transcriptional machinery that maintains cancer stem cell potential in MLLrearranged leukemia
Akihiko Yokoyama1, Hiroshi Okuda1, Satoshi Takahashi2

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special(1National Cancer Center, 2Kyoto University)

O-16 Plasticity and stemness in gastrointestinal tumorigenesis
Hiroshi Seno, Takahisa Maruno, Norihiro Goto, Akihisa Fukuda(Kyoto University, Department of Gastroenterology and Hepatology)

Lunch Time / Poster Session

12:30～14:00

Session 5: Tissue Stem Cells (II)

14:00～16:05

Chair Atsushi Hirao(Division of Molecular Genetics, Cancer Research Institute, Kanazawa University)

Kunimasa Ohta

(Department of Developmental Neurobiology, Kumamoto University Graduate School ofLife Sciences)O-17 Tsukushi dysfunction leads to hydrocephalus by altering neurogenesis in thesubventricular zone
Kunimasa Ohta, Adil Shah, Anam Mohammad, Naofumi Ito(Kumamoto University)

O-18 MT-nanotube mediated niche-stem cell signal specification
Mayu Inaba(University of Connecticut, Department of Cell Biology)

O-19 G 0 phase analysis of hematopoietic stem cell in mVenus-p27K- mice
Tsuyoshi Fukushima1, Yosuke Tanaka1, Toshihiko Oki2 , Toshio Kitamura1(1Division of cell therapy, Institute of medical science, Tokyo University,2
Department of Stem Cell and Regenerative Biology, Harvard University,
Cambridge)

15th Stem Cell Research Symposium

6

May 26 (Fri)-May 27 (Sat), 2017

(1Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University, 2YCI Labolatory for Immune Regeneration, RIKEN ResearchCenter for Integrative Medical Science, 3Labolatory for Developmental Genetics,
RIKEN Research Center for Integrative Medical Science)

O-21 Defining the stem cell lineages in the mouse inter-follicular epidermis
Aiko Sada1, Fadi Jacob2 , Eva Leung2 , Sherry Wang2 , Brian White3 ,David Shalloway2 , Tudorita Tumbar2(1University of Tsukuba, Life Science Center, Tsukuba Advanced Research
Alliance, Hiromi Yanagisawa Laboratory, 2Department of Molecular Biology andGenetics, Cornell University, USA, 3McDonnell Genome Institute, Washington
University, USA)(Institute for Fontier Life and Medical Science, Kyoto Univ.)

16:05～

Closing Remarks(Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences,
Kyushu University)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

Next Organizer Fumio Arai

Program / Poster

O-22 Orchestration of stem and progenitor cells drives abdominal skin expansion
during pregnancy
Fumiko Toyoshima

Program / 1st Day Program / 2nd Day

O-20 Role of the polycomb-group protein Pcgf1 in the lineage commitment ofhematopoietic stem and progenitor cells
Yaeko Nakajima-Takagi1, Motohiko Oshima1, Yusuke Isshiki1,
Tomokatsu Ikawa 2 , Junichiro Takano2 , Sha Si1, Kazumasa Aoyama1,
Atsunori Saraya1, Haruhiko Koseki3 , Atsushi Iwama1

Abstract / Poster

7

15th Stem Cell Research SymposiumPoster Session
P-1

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special
Abstract / Poster

Endothelial cell-selective adhesion molecule (ESAM) is required for the
ontogeny of definitive hematopoietic system in mice
Tomoaki Ueda1, Takafumi Yokota1, Yasuhiro Shingai1, Yukiko Doi1,
Tomohiko Ishibashi1,2 , Takao Sudo1,3 , Yasuhiro Nagate1, Akira Tanimura1,
Masahiro Tokunaga1, Jiro Fujita1, Michiko Ichii1, Sachiko Ezoe1,
Hirohiko Shibayama1, Kenji Oritani1, Yuzuru Kanakura1(1Department of Hematology and Oncology, Osaka University Graduate School of
Medicine, 2Department of Vascular Physiology, Research Institute National
Cerebral and Cardiovascular Center, 3Department of Immunology and Cell
Biology, Osaka University Graduate School of Medicine)

P-2

Program / Poster

Program / 2nd Day Program / 1st Day

May 26 (Fri)-May 27 (Sat), 2017

Hemidesmosomal component-mediated stem cell polarity and the cell divisionaxis determine hair follicle stem cell fate during aging
Hiroyuki Matsumura1, Nan Liu1, Aki Takada1, Daisuke Nanba1,
Shizuko Ichinose2 , Makoto Fukuda1, Elisabeth Geroges-laboohouse3 ,Shigeo Ohno4 , Emi K Nishimura1(1Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical
and Dental University, 2Division of human gene sciences research, ResearchCenter for Medical and Dental Sciences, Tokyo Medical and Dental University,
3
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Cell
Biology and Development,, 4Department of Molecular Biology, Yokohama City
University School of Medicine)

P-3

Variable SATB1 levels confer hematopoietic stem cell heterogeneity with
distinct lineage fate
Yukiko Doi1, Takafumi Yokota1, Yusuke Satoh1,2 , Tomoaki Ueda1,
Yasuhiro Shingai1, Michiko Ichii1, Akira Tanimura1, Sachiko Ezoe1,
Hirohiko Shibayama1, Kenji Oritani1, Terumi Kohwi-Shigematsu3 ,Yuzuru Kanakura1(1Department of Hematology and Oncology, Osaka University Graduate School of
Medicine, 2Department of Lifestyle Studies, Kobe Shoin Women’s University,
3
Department of Orofacial Sciences, University of California San Francisco)

P-4 Development of HSC-dependent and independent lineages in the mouse embryo
Tomomasa Yokomizo1, Naoki Watanabe2 , Tomoiku Takaku2 , Seiichi Mori3 ,Motomi Osato1,4 , Norio Komatsu2(1IRCMS, Kumamoto University, 2Department of Hematology, Juntendo University
School of Medicine, 3The Cancer Institute of JFCR, 4CSI, National University ofSingapore)

P-5 Aged hematopoietic stem cells enhance self-renewal program at single celllevel
Hiroshi Kobayashi1, Yusuke Shiozawa 2 , Seishi Ogawa 2 , Keiyo Takubo1(1Department of Stem Cell Biology, National Center for Global Health andMedicine, 2Department of Pathology and Tumor Biology, Kyoto University)

P-6 Asymmetric distribution of midbody and asymmetric cell division ofhematopoietic stem cells
Yosuke Tanaka, Tsuyoshi Fukushima, Toshio Kitamura(The University of Tokyo Institute of Medical Science Division of Cellular
Therapy)

15th Stem Cell Research Symposium

8

May 26 (Fri)-May 27 (Sat), 2017

Radiobiology of sphere-forming rat mammary epithelial cells under
nonadherent culture
Tatsuhiko Imaoka1, Ayaka Hosoki2 , Mari Ogawa1, Yukiko Nishimura 2 ,Shusuke Tani3 , Mayumi Nishimura1, Kazuhiro Daino1, Yutaka Yamada1,
Shizuko Kakinuma1, Yoshiya Shimada4(1Department of Radiation Effects Research, National Institute of Radiological
Sciences, National Institutes for Quantum and Radiological Science andTechnology, 2Radiation Effect Accumulation and Prevention Project, Fukushima
Project Headquarters, National Institute of Radiological Sciences, 3Radiobiology forChildren’s Health Program, National Institute of Radiological Sciences, 4National
Institutes for Quantum and Radiological Science and Technology)

P-8

Molecular response for low dose-rate irradiation in the hematopoietic system
Yoshinori Ohno1, Kyoko Suzuki-Takedachi1, Yun Guo2 , Naoto Shirasu3 ,Mimoko Santo1, Masamoto Kanno2 , Shin’ichiro Yasunaga 3 ,Motoaki Ohtsubo4 , Yoshihiro Takihara5

P-9 Dynamics of liver stem/progenitor cells during pregnancy
Satoshi Kozuki1,2 , Fumiko Toyoshima1,2(1Lab. of Tissue Homeostasis, Inst. for Front. Life and Med. Sci., Kyoto Univ.,
2
Grad. Sch. of Biostudies, Kyoto Univ.)(Department of Biosystems Science, Lab. of Tissue Homeostasis, Institute for
Frontier Life and Medical Science, Kyoto University)

P-11 Stem cells and their microenvironment as a candidate target of radiationinduced mammary carcinogenesis
Daisuke Iizuka, Megumi Sasatani, Hidehiko Kawai, Kenji Kamiya(Department of Experimental Oncology, Research Institute for Radiation Biology
and Medicine, Hiroshima University)

P-12 Mitochondria metabolism regulates the activation of hematopoietic stem cells
Terumasa Umemoto1, Yu Matsuzaki1, Michihiro Hashimoto1, Toshio Suda1,2(1International Research Center for Medical Science (IRCMS), 2Cancer Science
Institute of Singapore, National University of Singapore)

P-13 Differential effects of pregnancy on rat mammary carcinoma induction by preand post-pubertal radiation exposures
Masaru Takabatake1, Tatsuhiko Imaoka1, Kazuhiro Daino1, Kaye Showler2 ,Ayaka Hosoki2 , Yukiko Nishimura1, Mayumi Nishimura1,
Shizuko Kakinuma1, Masahiro Fukushi3 , Yoshiya Shimada4

9

15th Stem Cell Research Symposium

Abstract / Poster(1Departmet of Radiation Effects Research, National Institute of Radiological
Sciences, National Institutes for Quantum and Radiological Science andTechnology, 2National Institute of Radiological Sciences, 3Tokyo Metropolitan
University, 4National Institutes for Quantum and Radiological Science andTechnology)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-10 Interfollicular epidermal cell dynamics in the process of abdominal skincontraction after parturition
Takuya Okada, Ryo Ichijo, Mitsuko Fukuhara, Fumiko Toyoshima

Program / Poster(1Dept. Stem Cell Biol., RIRBM, Hiroshima Univ., 2Dept. Immunol., Grad. Sch.
Biomed. Sci., Hiroshima Univ., 3Dept. Biochem., Facul. Med., Fukuoka Univ., 4Dept.
Food and Ferment. Sci., Beppu Univ., 5Japanese Red Cross Osaka Blood Center.)

Program / 1st Day Program / 2nd Day

P-7

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 26 (Fri)-May 27 (Sat), 2017

P-14 Human bone-derived SSEA-4 and CD271 double positive mesenchymal stromalcells accelerated aging by TGF-beta 2
Hiroshi Kawamura, Ryusuke Nakatsuka, Keisuke Sumide,
Yoshikazu Matsuoka, Yasumasa Shirouzu, Tatsuya Fujioka,
Yoshiaki Sonoda(Department of Stem Cell Biology, Graduate School of Medical Science, Kansai
Medical University)

P-15 Role of Kdm2b, a component of non-canonical PRC1.1, in hematopoiesis
Yusuke Isshiki1, Yaeko Nakajima-Takagi1, Motohiko Oshima1,
Kazumasa Aoyama1, Haruhiko Koseki2 , Atsushi Iwama1(1Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University, 2Laboratory for Developmental Genetics, RIKEN ResearchCenter for Integrative Medical Science)

P-16 Roles of miR-17 family in the age-related dysfunctions of tissue stem cells
Hayato Naka-Kaneda1, Daisuke Hisamatsu2(1Dept. Anatomy, Shiga Univ. Med. Sci., 2Dept. Physiol., Keio Univ. Sch. Med.)

P-17 Setdb1 maintains HSPCs by restricting the ectopic activation of nonhematopoietic genes
Shuhei Koide, Motohiko Oshima, Eriko Nitta, Atsunori Saraya,
Kazumasa Aoyama, Yuko Kato, Satoru Miyagi, Yaeko Nakajima-Takagi,
Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University)

P-18 CHD7 specifies stem cell identity and neurogenic potential in human central
nervous system
Tsukasa Sanosaka, MuhChyi Chai, Hironobu Okuno, Satoe Banno,
Ikuko Koya, Zhi Zhou, Hideyuki Okano, Jun Kohyama(Department of Physiology, Keio University School of Medicine)P-19 Functional defect of Polycomb group complex during hematopoietic stem cellaging and myelid malignancies
Motohiko Oshima1, Kazumasa Aoyama1, Changshan Wang2 , Shuhei Koide1,
Atsushi Iwama1(1Dept. Cell. Mol. Med., Chiba Univ., 2Coll. Life Sci., Inn. Mong. Univ.)

P-20 Role of the polycomb group protein Bmi1 in hematopoietic stem cell aging
Eriko Nitta, Atsunori Saraya, Shuhei Koide, Motohiko Oshima,
Atsushi Iwama(Cellular Molecular Medicine, Chiba University Graduate School of Medicine)P-21 Abcg2-induced MDS/AML cells perturb bone formation by inhibiting
osteoblastic differentiation of bone marrow mesenchymal stem cells
Yasutaka Hayashi1, Kimihito Kawabata 2 , Yasufumi Uehara3 ,Yosuke Tanaka1, Yuya Kunisaki3 , Susumu Goyama1, Toshio Kitamura1(1Division of Cellular Therapy, The Institute of Medical Science, The University ofTokyo, 2Division of Hematology/ Medical Oncology, Department of Medicine,
Weill-Cornell Medical College, Cornell University, 3Department of Stem Cell
Biology and Medicine/Cancer Stem Cell Research, Graduate School of Medical
Sciences, Kyushu University)

15th Stem Cell Research Symposium

10

May 26 (Fri)-May 27 (Sat), 2017

(1Laboratory of Molecular Embryology, Yokohama City University, 2Laboratory of
Endocrinology, Yokohama City University, 3Laboratory of Regenerative Biology,
Yokohama City University)

P-23 The loss of Bmi1 promotes age-associated changes in bone marrow niche cells
Li-Bo Hou1, Sha Si1, Motohiko Oshima1, Yuko Kato1, Erico Nitta1,
Yaeko Nakajima1, Satoshi Yamazaki2 , Atsushi Iwama1(1Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University., 2Project division of advanced regenerative medicine, theuniversity of Tokyo, the institute of medical science.)(1Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University, 2Division of Stem Cell Therapy, Center for Stem Cell andRegenerative Medicine, The Institute of Medical Science, The University of Tokyo,
3
Department of Cell Differentiation, The Sakaguchi Laboratory, School of
Medicine, Keio University, 4Department of Cardiovascular Biology and Medicine,
Niigata University Graduate School of Medical and Dental Sciences,; PRESTO,
Japan Science and Technology Agency)(Division of Developmental Biology, Research Center for Genomic Medicine,
Saitama Medical University)

P-26 Baf53a deficiency inhibits cell proliferation and Baf53b substitutes forfunctions of Baf53a in mouse embryonic stem cells
Bo Zhu, Atsushi Ueda, Xiaohong Song, Tadayuki Akagi, Takashi Yokota(Department of Stem Cell Biology, Graduate School of Medical Sciences,
Kanazawa University)

P-27 O-GlcNAc is essential for the transition from primed state to naïve state ofmouse pluripotent stem cells
Taichi Miura1,2 , Shoko Nishihara1(1Department of Bioinformatics, Graduate School of Engineering, Soka University,
2
National Institute of Radiological Sciences, Department of Basic Medical Sciencesfor Radiation Damages, Regenerative Therapy Research Team)

P-28 Generation of reporter ESC lines to study trophoblast fate specification
Masatoshi Ohgushi(RIKEN CDB, Laboratory for in vitro Histogenesis)(1Department of Cardiology, Keio University School of Medicine, 2Laboratory
Animal Resource Center, University of Tsukuba, 3Department of Physiology, Keio
University School of Medicine, 4Department of Obstetrics and Gynecology, Keio
University School of Medicine)11

15th Stem Cell Research Symposium

Abstract / Poster

P-29 H1foo has a pivotal role in qualifying induced pluripotent stem cells
Akira Kunitomi1, Shinsuke Yuasa1, Fumihiro Sugiyama 2 , Hideyuki Okano3 ,Ken-ichi Yagami2 , Mamoru Tanaka4 , Keiichi Fukuda1

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-25 Mbd3 variant lacking methyl-CpG binding domain exerts equivalent function
to canonical Mbd3 for preserving ESC pluriptency
Masataka Hirasaki, Ayumu Suzuki, Kousuke Uranishi, Masamitsu Asaka,
Masazumi Nishimoto, Akihiko Okuda

Program / Poster

P-24 The impact of p53 activation in bone marrow vascular niche cells on
hematopoiesis
SHA SI1, Yaeko Nakajima-Takagi1, Motohiko Oshima1, Atsunori Saraya1,
Satoshi Yamazaki2 , Libo Hou1, Yoshiaki Kubota 3 , Tohru Minamino4 ,Atsushi Iwama1

Program / 1st Day Program / 2nd Day

P-22 Jagged1 expression in Sertoli cells is controlled by cAMP
Ryu Okada1, Taro Hara1, Tomomi Sato2 , Nobuhiko Kojima3 , Yukio Nishina1

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 26 (Fri)-May 27 (Sat), 2017P-30 AKT promotes somatic cell nuclear reprogramming through α-KG
Akari Matsumoto1, Yoichi Sekita1, Yuki Kawasaki2 , Yuki Sugiura3 ,Ryo Konno4 , Yoshio Kodera4 , Takashi Kohda 2 , Fumitoshi Ishino2 ,Tohru Kimura1(1Lab Stem Cell Biol, Kitasato Univ., 2TMDU, 3Keio Univ., 4Lab Biophysics, Kitasato
Univ.)

P-31 A novel megakaryocyte-based screening system identifies molecules that
promote production of platelets in vitro
Si Jing Chen1, Hideya Seo1, Akitsu Hotta 2 , Yohei Nishi2 , Akira Ohta 2 ,Koji Eto1(1Department of Clinical Application, Center for iPS Cell Research and Application,
Kyoto University, 2Department of Life Science Frontiers, Center for iPS Cell
Research and Application, Kyoto University)

P-32 Drug screening for GM1 gangliosidosis using the patient-derived iPS cells
Ryutaro Kajihara, Takumi Era(Department of Cell Modulation, Institute of Molecular Embryology and Genetics,
Kumamoto University)

P-33 Induced cancer stem cells: a model for studying cancer stem cell dormancy
and recurrence
Akira Shimamoto, Tahara Hidetoshi(Department of Cellular and Molecular Biology, Graduate School of Biomedical &Health Sciences, Hiroshima University)

P-34 Single-cell gene expression analysis reveals a novel candidate AML stem cellassociated antigen, ALCAM
Arika Shimura-Nukina, Yosuke Masamoto, Yuki Kagoya, Shunya Arai,
Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine, The
University of Tokyo)

P-35 mTORC2-mediated metabolic processes contributes drug resistance inleukemia
Masaya Ueno, Hui Peng, Atsushi Hirao(Division of Molecular Genetics, Cancer Research Institute, Kanazawa University)

P-36 Identification of potential stemness-maintaining factors in cancer stem cells
Takahiko Murayama1, Tatsunori Nishimura 2 , Kana Tominaga1,
Asuka Nakata 2 , Masao Yano3 , Kei-ichiro Tada4 , Arinobu Tojo1,
Noriko Gotoh1,2(1Division of Molecular Therapy, Institute of Medical Science, University of Tokyo,
2
Division of Cancer Cell Biology, Cancer Research Institute of Kanazawa
University, 3Department of Breast Surgery, Minamimachida Hospital, 4Department
of Breast & Endocrine Surgery, Graduate School of Medicine, University of Tokyo)

P-37 Screening for human pancreatic cancer stem cell niche mimicry by usingsynthetic polymer microarrays
Yoshitaka Murota1, Sara Schmidt2 , Kouichi Tabu1, Hiromitsu Ito3 ,Shinji Tanaka3,4 , Mark Bradley2 , Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU), 2High-Throughput Chemical Biology, School ofChemistry, University of Edinburgh, 3Department of Hepato-Billary-Pancreatic
Surgery, Graduate School of Medicine, Tokyo Medical and Dental University(TMDU), 4Department of Molecular Oncology, Graduate School of Medicine, Tokyo
Medical and Dental University (TMDU)

15th Stem Cell Research Symposium

12

May 26 (Fri)-May 27 (Sat), 2017

(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Science, Kyushu University)

P-39 Establishment of novel circadian rhythm sleep disorder model using
pluripotent stem cells
Hiroyuki Tamiya1, Sumito Ogawa1, Yasuyoshi Ouchi2 , Masahiro Akishita1(1Department of Geriatric Medicine, The University of Tokyo Hospital,
2
Toranomon Hospital)

P-40 The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and
RUNX1-RUNX1T1
Taishi Yonezawa1, Hirotaka Takahashi2 , Shiori Shikata1, Shyuhei Asada1,
Tsuyoshi Fukushima1, Tomofusa Fukuyama1, Yosuke Tanaka1,
Tatsuya Sawasaki2 , Toshio Kitamua1, Susumu Goyama1

P-41 Physiological roles of the genes expressed during maternal zygotic transition
Satoko Kanzaki1, Mizuki Wakabayashi1, Shuji Takada 2 , Yoichi Sekita1,
Tohru Kimura1(1Kitasato University, 2National Center for Child Health and Development)(1Laboratory of Stem Cell Biology, Kitasato University School of Science,2
Dana-Farber Cancer Institute)P-43 Identification and analysis of imprinting control region-binding proteins
Yoichi Sekita1, Yuki Yoshimura1, Hodaka Fujii2 , Kimura Tohru1(1Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University
School of Science, 2Research Institute for Microbial Diseases, Osaka University)

P-44 Identification of novel human hematopoietic stem cell subpopulations via
comprehensive surface marker analysis
Takashi Jiromaru, Kohta Miyawaki, Yasuo Mori, Hiromi Iwasaki,
Takahiro Maeda, Koichi Akashi(Medicine and Biosystemic Science, Kyushu University)

P-45 Role of the polycomb methyltransferase Ezh1 in EZH2-insufficient
myelodysplastic syndrome
Kazumasa Aoyama1, Emi Suzuki1, Makiko Mochizuki-Kashio1,Motohiko Oshima1, Shuhei Koide1, Yaeko Nakajima-Takagi1, Goro Sashida1,2 ,Atsushi Iwama1(1Dept. of Cel. and Mol. Med., Grad. Sch. of Med., Chiba Univ., 2IRCMS, Kumamoto
Univ.)(Department of hematological Malignancy, Institute of Medical Science, Tokai
University)

13

15th Stem Cell Research Symposium

Abstract / Poster

P-46 Dramatically increased myelopoiesis in the bone marrow of EBV-infected
humanized NOG mice
Yasuhiro Katahira

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-42 Essential roles of Snf5 in female germ cell sex differentiation
Toshiaki Ito1, Yoichi Sekita1, Charles Roberts2 , Tohru Kimura1

Program / Poster(1Division of Cellular Therapy The Institute of Medical Science The university ofTokyo, 2Proteo-Science Center (PROS) Ehime University)

Program / 1st Day Program / 2nd Day

P-38 Development of a novel anti-leukemic therapy targeting the circadian clock
genes
Tomoko Hyoda, Yuya Kunisaki, Kentaro Hosokawa, Fumio Arai