2019 年 5 月 24 日（金）－25 日（土）1 日目：5 月 24 日（金）2 日目：5 月 25 日（土）2F メインホール

8:00

2F メインホール

8:30~10:15

8:00

▶P.22

Session 4

9:00

9:00

O-14~O-17
座長：山田 泰広
後藤 由季子
10:00

10:00
10:15~10:35

休憩

10:35~12:20

11:00

▶P.24

11:00

Session 5
O-18~O-22
座長：林 克彦

12:00

12:00
12:20~12:35

全体会議

12:35~13:20

13:00

13:00~13:05
13:05~15:00

休憩

開会の辞
▶P.16

13:20~15:35

13:00
▶P.27

Session 1
O-01~O-06

14:00

Session 6

座長：新井 文用
岩間 厚志
15:00

15:00~15:15

O-23~O-29
座長：黒川 峰夫
北林 一生

休憩

15:15~16:45

15:00

▶P.19
15:35~15:40

Session 2
O-07~O-10

16:00

14:00

閉会の辞
16:00

座長：田久保 圭誉

17:00

16:45~17:00

休憩

17:00~18:15

Session 3

17:00

▶P.21

O-11~O-13
座長：田賀 哲也

18:00

18:00

18:30~20:00

19:00

19:00

Poster Session

20:00

20:00

第 17 回幹細胞シンポジウム22019 年 5 月 24 日（金）－25 日（土）13:00～13:05

開会の辞

世話人

後藤

由季子

（東京大学大学院薬学系研究科

分子生物学教室）

13:05～15:00

Session 1

座長

新井

文用

岩間

厚志

（九州大学大学院医学研究院（東京大学医科学研究所

応用幹細胞医科学部門

幹細胞再生修復医学分野）

幹細胞治療研究センター）

特別講演

O-01（13:05～13:35）
Mitochondria-Lysosome Metabolism in Hematopoietic Cells
Toshio Suda

(Cancer Science Institute (CSI), National University of Singapore (NUS), 14
Medical Drive, #12-01, Singapore, 117599
IRCMS, Kumamoto University)O-02（13:35～13:50）
Environmental optimization enables maintenance of quiescent hematopoietic stem
cells ex vivo
Hiroshi Kobayashi, Takayuki Morikawa, Keiyo Takubo(Research Institute National Center for Global Health and Medicine)

O-03（13:50～14:15）
In vivo single cell analysis resolves hematopoietic stem cell heterogeneity and aging
Ryo Yamamoto1, Hiromitsu Nakauchi1,2,3(1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
School of Medicine, 2Department of Genetics, Stanford University, 3Division ofStem Cell Therapy, Center for Stem Cell Biology and Regeneration Medicine,
Institute of Medical Science, University of Tokyo)(Laboratory of Transcriptional Regulation in Leukemogenesis, International
Research Center for Medical Sciences, Kumamoto University)O-05（14:30～14:45）
Regulation of neural stem cell fate by histone modifications
Masafumi Tsuboi1, Yusuke Kishi2 , Wakana Yokozeki2 , Haruhiko Koseki3 ,Yusuke Hirabayashi1, Yukiko Gotoh2(1Graduate School of Engineering, The University of Tokyo, 2Graduate School of
Pharmaceutical Sciences, The University of Tokyo, 3RIKEN Center for Integrative
Medical Sciences)3

第 17 回幹細胞シンポジウム

抄録（ポスター）

O-04（14:15～14:30）
Tet2 loss reshapes the binding regions of Hmga2 and promotes the development of
myelodysplastic syndrome
Goro Sashida

抄録 口演（２日目）

招待講演

プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

5 月 24 日（金） 【１日目】

2019 年 5 月 24 日（金）－25 日（土）プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

O-06（14:45～15:00）
MBD3 contributes to the differentiation competence of ESCs into EpiLCs via therecruitment of PRC2 complex
Masataka Hirasaki, Kousuke Uranishi, Yuka Kitamura, Ayumu Suzuki,
Masazumi Nishimoto, Akihiko Okuda(Division of Developmental Biology, Research Center for Genomic Medicine,
Saitama Medical University)

休憩

15:00～15:15

Session 2

15:15～16:45

座長

田久保

圭誉

（国立国際医療研究センター研究所

生体恒常性プロジェクト）

招待講演

O-07（15:15～15:40）
細胞競合による上皮の恒常性維持機構
井垣 達吏（京都大学大学院生命科学研究科

システム機能学分野）

招待講演

O-08（15:40～16:05）
Stem cell competition orchestrates skin homeostasis and ageing
Nan Liu1, Hiroyuki Matsumura1, Tomoki Kato1, Shizuko Ichinose2 ,Aki Takada 2 , Takeshi Namiki3 , Kyosuke Asakawa1, Hironobu Morinaga1,
Yasuaki Mohri1, Adèle De Arcangelis4 , Elisabeth Geroges-Labouesse4 ,Daisuke Nanba1, Emi K. Nishimura1

抄録 口演（２日目）(1Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical
and Dental University, 2Research Center for Medical and Dental Sciences, Tokyo
Medical and Dental University, 3Department of Dermatology, Tokyo Medical and
Dental University Graduate School and Faculty of Medicine, 4Institut de Génétiqueet de Biologie Moléculaire et Cellulaire, Development and Stem Cells Department,
CNRS UMR7104, Inserm U1258, Université de Strasbourg, Illkirch, France)

招待講演

O-09（16:05～16:30）
一つ一つの幹細胞のランダムなふるまいが安定した精子形成を支える吉田 松生

抄録（ポスター）（基礎生物学研究所）

O-10（16:30～16:45）
Regulation of dormant state of oocyte by mechanical stress involved in nuclear
rotation
Go Nagamatsu, Katsuhiko Hayashi(Kyushu University)

16:45～17:00

休憩

第 17 回幹細胞シンポジウム

42019 年 5 月 24 日（金）－25 日（土）

座長

田賀

哲也

（東京医科歯科大学

難治疾患研究所

幹細胞制御分野）

招待講演

O-11（17:00～17:25）
Visualization of turbulent flow in vivo and computer simulation in vitro enabled
production of 100 billion-order platelets from iPSCs
Koji Eto(Center for iPS Cell Research and Application, Kyoto University, Japan)

招待講演

O-12（17:25～17:50）
生後脳組織の維持・再生における新生ニューロンの移動
澤本 和延（名古屋市立大学大学院医学研究科

再生医学分野）招待講演

O-13（17:50～18:15）
Unravel the mysteries of cancer cell dormancy in brain metastasis
Eishu Hirata(Division of Tumor Cell Biology and Bioimaging, Cancer Research Institute ofKanazawa University)

18:30～20:00

Poster Session

プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

17:00～18:15

Session 3

抄録 口演（２日目）
抄録（ポスター）5

第 17 回幹細胞シンポジウム

2019 年 5 月 24 日（金）－25 日（土）プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

5 月 25 日（土） 【２日目】
8:30～10:15

Session 4

座長

山田

泰広

後藤

由季子

（東京大学医科学研究所

システム疾患モデル研究センター）（東京大学大学院薬学系研究科

分子生物学教室）

招待講演

O-14（8:30～8:55）
幹細胞による試験管内胚盤胞再構成の試み
大日向 康秀（理化学研究所

生命医科学研究センター

免疫器官形成研究チーム）

招待講演

O-15（8:55～9:20）
ヒトナイーブ型多能性幹細胞とヒト初期発生
高島 康弘（京都大学 iPS 細胞研究所

CiRA

未来生命科学開拓部門）

招待講演

O-16（9:20～9:45）
Reconstitution and understanding of mammalian oogenesis
Katsuhiko Hayashi(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)

特別講演

抄録 口演（２日目）

O-17（9:45～10:15）
インテリジェント画像活性細胞選抜法がもたらす生物学の新展開
合田 圭介1,2,3,4（1 東京大学大学院理学系研究科、2 武漢大学工業科学研究院、3 株式会社 CYBO、
4
株式会社 Cupido）

抄録（ポスター）休憩

10:15～10:35

Session 5

10:35～12:20

座長

林

克彦

（九州大学医学研究院

応用幹細胞医科学

ヒトゲノム幹細胞医学）

招待講演

O-18（10:35～11:00）
ダイレクトリプログラミングの発生・再生学への応用
家田 真樹（筑波大学医学医療系

第 17 回幹細胞シンポジウム

循環器内科）

6

2019 年 5 月 24 日（金）－25 日（土）(Kumamoto University)

招待講演

O-20（11:15～11:40）
環境適応と心臓再生能
木村航（理化学研究所

多細胞システム形成研究センター

心臓再生研究チーム）

招待講演

O-21（11:40～12:05）
細胞系譜の直接転換による潰瘍面からの新規上皮化の誘導栗田 昌和（東京大学医学部附属病院

形成外科）

O-22（12:05～12:20）
IL-1 and TNFa in the inflammatory niche enhance the proliferation of alveolar type 2
epithelial cell and contribute to alveolar regeneration
Hiroaki Katsura, Yoshihiko Kobayashi, Purushothama Tata, Brigid Hogan(Duke University)

12:20～12:35

全体会議

代表幹事 赤司浩一（九州大学大学院医学研究院

病態修復内科学）

12:35～13:20

Session 6

13:20～15:35

座長

黒川

峰夫

北林

一生

（東京大学医学部附属病院）（国立がん研究センター

研究所

造血器腫瘍研究分野）

O-23（13:20～13:45）
The role of endothelial stem cell in vascular regeneration
Hisamichi Naito(Department of Signal Transduction, Research Institute for Microbial Diseases,
Osaka University)O-24（13:45～14:00）
Analysis with an alternative marker for Sca-1 revealed unexpected hematopoietic
responses during infection
Masashi Kanayama, Toshiaki Ohteki(Department of Biodefense Research, Medical Research Institute, Tokyo Medical
and Dental University)

7

第 17 回幹細胞シンポジウム

抄録（ポスター）

招待講演

抄録 口演（２日目）

休憩

プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

O-19（11:00～11:15）
Transdifferentiation of human somatic cells by ribosome
Kunimasa Ohta

2019 年 5 月 24 日（金）－25 日（土）プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

O-25（14:00～14:15）
Patient-derived induced pluripotent stem cells revealed calcium/calmodulin dependent
protein kinase 2 gamma as a therapeutic target of myelofibrosis
Masashi Miyauchi, Ken Sasaki, Kazuki Taoka, Yosuke Masamoto,
Sho Yamazaki, Shunya Arai, Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine,
The University of Tokyo)

招待講演

O-26（14:15～14:40）
Deciphering and Engineering Human Hematopoietic Development
Ryohichi Rio Sugimura(CiRA)

O-27（14:40～14:55）
LMO2 activation by NAMPT-NAD+-SIRT2 pathway mediated deacetylation isindispensable for early hematopoiesis and T-ALL leukemogenesis
Tatsuya Morishima1,2 , Ann-Christin Krahl2 , Yun Xu2 , Narges Aghaallaei2 ,Masoud Nasri2 , Maksim Klimiankou2 , Malte Ritter2 , Marcus D Hartmann3 ,Betül Findik2 , Sylwia Stefanczyk2 , Christian Lindner2 , Benedikt Oswald2 ,Regine Bernhard2 , Karin Hähnel2 , Ursula Hermanutz-Klein2 , Lothar Kanz2 ,Baubak Bajoghli2 , Maya Andre4,5, Patrick Müller6 , Karl Welte4 ,Julia Skokowa 2(1International Research Center for Medical Sciences, Kumamoto University,
Kumamoto, Japan, 2Department of Oncology, Hematology, Immunology,
Rheumatology and Pulmonology, University Hospital Tübingen, Germany,
3
Department of Protein Evolution, Max Planck Institute for Developmental
Biology, Tübingen, Germany, 4University Children’s Hospital Tübingen, Germany,
5
University of Basel Children’s Hospital, Dep. of Pediatric Intensive Care, Basel,
Switzerland, 6Friedrich Miescher Laboratory of the Max Planck Society,
Tübingen, Germany)

抄録 口演（２日目）

O-28（14:55～15:10）
miR-221 targets an RNA-binding protein QKI-5 and enhances the tumorigenic capacityof human colorectal cancer stem cells
Yohei Shimono1, Junko Mukohyama 2 , Takanori Hayashi1,
Takashi Watanabe1, Taichi Isobe3 , Qingjiang Hu4 , Debashis Sahoo5,
Hironobu Minami6 , Koshi Mimori4 , Piero Dalerba 2 , Yoshihiro Kakeji6 ,Akira Suzuki6

抄録（ポスター）(1Fujita Health University School of Medicine, 2Columbia University, 3Kyushu
University, 4Kyushu University Beppu Hospital, 5University of California San
Diego, 6Kobe University Graduate School of Medicine)

招待講演

O-29（15:10～15:35）
iPS 細胞技術によるがん細胞の理解と制御
山田 泰広（東京大学医科学研究所 システム疾患モデル研究センター
先進病態モデル研究分野）

15:35～15:40

閉会の辞

次期世話人 滝澤仁

		 （熊本大学国際先端医学研究機構）

第 17 回幹細胞シンポジウム

82019 年 5 月 24 日（金）－25 日（土）P-01 Age-dependent decrease in requirement for glycolysis in hematopoietic stem
cells
Shintaro Watanuki, Hiroshi Kobayashi, Daiki Karigane,
Takayuki Morikawa, Keiyo Takubo(National Center for Global Health and Medicine, Division of Stem Cell Biology)

P-02 A system for construction and observation of mosaic mammary gland towards
exploration of the hypothetical cell competition between irradiated and nonirradiated cells
Tatsuhiko Imaoka, Yukiko Nishimura, Ken-ichi Kudo, Mayumi Nishimura,
Kazuhiro Daino, Daisuke Iizuka, Mari Ogawa, Misuzu Fujita,
Shizuko Kakinuma(QST)

P-03 Low dose-rate irradiation preferentially affects hematopoietic stem cell
activity
Yoshinori Ohno1, Kyoko Suzuki-Takedachi1, Yun Guo2 , Masamoto Kanno2 ,Naoto Shirasu3 , Shin’ichiro Yasunaga 3 , Motoaki Ohtsubo4 ,Yoshihiro Takihara1,5(1Dept. Stem Cell Biol., RIRBM, Hiroshima Univ., 2Dept. Immunol., Grad. Sch.
Biomed. Sci., Hiroshima Univ., 3Dept. Biochem., Facul. Med., Fukuoka Univ., 4Dept.
Food and Ferment. Sci., Beppu Univ., 5Japanese Red Cross Osaka Blood Center.)

P-04 Elucidation of a mechanism regulating the expansion-to-neurogenic transition in
neocortical neural progenitor cells
Naohiro Kuwayama, Yusuke Kishi, Yurie Nishiumi, Yukiko Gotoh(The university of Tokyo)(1Graduate School of Pharmaceutical Sciences, The University of Tokyo,
2
Department of Computational Biology and Medical Sciences, Graduate School of
Frontier Sciences, The University of Tokyo)(1Center for iPS Cell Research & Application, Kyoto University, 2RIKEN Center
for Biosystems Dynamics Research)

P-07 Acute gut inflammation orchestrates early hematopoiesis via innate immune
signaling
Yoshikazu Hayashi1, Maiko Sezaki1, Sumit Sheoran1, Tatsuya Morishima1,
Gaku Nakato2 , Shinji Fukuda 2,3 , Hitoshi Takizawa1(1Laboratory of Stem Cell Stress, International Research Center for Medical
Sciences, Kumamoto University, Kumamoto, Japan, 2Kanagawa Institute ofIndustrial Science and Technology, Kanagawa, Japan, 3Institute for Advanced
Biosciences, Keio University, Yamagata, Japan)

9

第 17 回幹細胞シンポジウム

抄録（ポスター）

P-06 Transcriptional profiling of aged intestinal stem cells, progenitor cells and thestem cell niche
May Nakajima-Koyama1, Takuya Yamamoto1, Eisuke Nishida 2

抄録 口演（２日目）

P-05 Identification and characterization of embryonic origin of adult subventricularneural stem cells
Shima Yamaguchi1, Takaaki Kuniya1, Hanae Omiya1, Daichi Kawaguchi1,
Yutaka Suzuki2 , Yukiko Gotoh1

プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

Poster Session

2019 年 5 月 24 日（金）－25 日（土）プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

P-08 Investigation of niche signals for the maintenance of embryonic origin of adultneural stem cells
Yuewen Ding, Daichi Kawaguchi, Yukiko Gotoh(Graduate school of pharmaceutical sciences, The University of Tokyo)

P-09 Spatiotemporal patterning of epithelial Sox2 and Gata4 orchestrates theformation of a squamous-columnar junction in a mouse stomach
Nao Sankoda1, Yasuhiro Yamada1, Yoshiya Kawaguchi2(1Center for Experimental Medicine and System Biology, Institute of Medical
Science, University of Tokyo, 2Center for iPS Cell Research and Application, Kyoto
University)

P-10 Hoxa10 regulates adult muscle regeneration in a body-region-specific manner
Yusuke Ono1, Yasuo Kitajima1, Daiki Seko1, Jumpei Nogami2 ,Yoshifumi Tsuchiya1, Shizuka Ogawa3 , Narihiro Okazaki3 ,Akihiko Yonekura3 , Seigo Ohba3 , Yoshinori Sumita3 , Ko Chiba3 ,Izumi Asahina3 , Yasuyuki Ohkawa 2 , Kiyoshi Yoshioka1(1Department of Muscle Development and Regeneration, Institute of Molecular
Embryology and Genetics, Kumamoto University, 2Division of Transcriptomics,
Medical Institute of Bioregulation, Kyushu University, 3Nagasaki University
Graduate School of Biomedical Sciences)P-11 Autophagy-Independent Neonatal Hematopoiesis
Michihiro Hashimoto1, Terumasa Umemoto1, Tomomasa Yokomizo1,
Toshio Suda1,2(1IRCMS, Kumamoto University, 2CSI, National University of Singapore)

P-12 Trim28 participates in neuro-gliogenic potential change of neural stem cells
Takumi Nakagawa(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)

抄録 口演（２日目）

P-13 p53 Deficiency in Mesenchymal Stem Cells Alters Stress Hematopoiesis andDevelops Fibrosarcoma
Yuriko Sorimachi1,2 , Nobuhito Goda 2 , Keiyo Takubo1(1Department of Stem Cell Biology, Research Institute, National Center for Global
Health and Medicine, 2Department of Life Sciences and Medical BioScience,
Waseda University School of Advanced Science and Engineering)

P-14 Activation of Keap1-Nrf2 pathway in HSCs during aging
Motohiko Oshima1, Wakako Kuribayashi2 , Yaeko Nakajima-Takagi1,
Kazumasa Aoyama 3 , Shuhei Koide2 , Naoki Itokawa 2 , Atsushi Iwama1

抄録（ポスター）(1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology andRegenerative Medicine, Institute of Medical Science, University of Tokyo, 2Divisionof Stem Cell and Molecular Medicine, Center for Stem Cell Biology andRegenerative Medicine, Institute of Medical Science, University of Tokyo,
3
Department of Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University)

P-15 Identifying a new stem/progenitor like population of vascular resident
endothelial cells
Tomohiro Iba1, Hisamichi Naito1, Hideya Kawaji2 , Tsukasa Kouno2 ,Nobuyuki Takakura1(1Dept. of Signal Transduction, RIMD, Osaka Univ., 2Div. of Genomic Medicine,
IMS, Riken)

第 17 回幹細胞シンポジウム

102019 年 5 月 24 日（金）－25 日（土）(1IRCMS, Kumamoto University, 2CSI, National University of Singapore)

P-17 Regular division and stochastic state switch of Plvap+ spermatogenic stem cells
in homeostasis
Toshinori Nakagawa(National Institute for Basic Biology)

P-18 Induction of vascular endothelial cells from feeder free iPS cells using 3D
suspension culture
Shinako Masuda, Katsuhisa Matsuura, Tatsuya Shimizu(Institute of Advanced Biomedical Engineering and Science Tokyo Women’s
Medical University)

P-19 Characterization of the progenitor cell state during ESC-to-trophoblast
differentiation
Masatoshi Ohgushi(Institute for Frontier Life and Medical Bioscience, Kyoto University)

P-20 Cell type-specific one-step in vivo sarcoma model unveiled cell-of-origin and its
critical role in EWS/ATF1-induced sarcomas
Kenji Ito1, Shingo Komura 2 , Yasuhiro Yamada1(1Division of Stem Cell Pathology, Institute of Medical Science, The University ofTokyo, 2Department of Orthopaedic Surgery, Gifu University Graduate School of
Medicine)

P-21 Establishment of primitive endoderm like cells from human naïve pluripotent
stem cells
Takumi Okubo, Yasuhiro Takashima(Department of Life Science Frontiers, Center for iPS Cell Research andApplication, Kyoto University)(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)

P-23 Role of PCGF factors during ES cell differentiation
Hiroki Sugishita1,2 , Shinsuke Ito1, Takashi Kondo1, Haruhiko Koseki1,2

P-24 Hsa-miR-302s are essential for self-renew of human pluripotent stem cells
Tohru Sugawara, Hidenori Akutsu, Akihiro Umezawa(National Center for Child Health and Development)

P-25 Transcriptional regulatory networks controlling the oocyte identity
Nobuhiko Hamazaki, So Shimamoto, Orie Hikabe, Norio Hamada,Katsuhiko Hayashi(Department of Developmental Stem Cell Biology, Faculty of Medical Sciences,
Kyushu University, Japan)

11

第 17 回幹細胞シンポジウム

抄録（ポスター）(1RIKEN IMS, Laboratory for Developmental Genetics, 2Chiba University,
Graduate School of Medicine)

抄録 口演（２日目）

P-22 Hypoxia induces the dormant state in oocytes through expression of Foxo3
So Shimamoto, Yohei Nishimura, Go Nagamatsu, Norio Hamada,
Haruka Kita, Orie Hikabe, Nobuhiko Hamazaki, Katsuhiko Hayashi

プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

P-16 Low energy metabolism contributes to the maintenance of hematopoietic stem
cells
Terumasa Umemoto1, Michihiro Hashimoto1, Toshio Suda1,2

2019 年 5 月 24 日（金）－25 日（土）プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

P-26 Cell-Matrix Adhesion Modulates Pluripotent Stem Cell Differentiation toward
Hematopoietic Cells
Akinori Yuzuriha1, Naoshi Sugimoto1, Sou Nakamura1, Koji Eto1,2(1Center for iPS Cell Research and Application, Kyoto University, Kyoto Japan,
2
Department of Regenerative Medicine, Chiba University Graduate School of
Medicine, Chiba, Japan)

P-27 Autoschizis-like spontaneous necrosis mediates a self-expanding strategy ofglioma stem cells by modulating tumor-associated macrophages
Kouichi Tabu1, Wenyu Liu1, Takuichiro Hide2 , Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU), 2Department of Neurosurgery, Graduate School of
Medical Sciences, Kumamoto University)

P-28 Enhanced erythropoiesis in bone marrow of C6 glioma-bearing mice
Alapati Aimaitijiang, Kouichi Tabu, Wenqian Wang, Ikuo Nobuhisa,
Tetsuya Taga

(Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU))

P-29 Activated pentose phosphate pathway mediated by Fbp1 upregulation supports
leukemia initiation of AML with high Evi1 expression
Hideaki Mizuno, Yuki Kagoya, Junji Koya, Yosuke Masamoto,
Mineo Kurokawa(Graduate School of Medicine, The University of Tokyo)

P-30 MCM10 maintains breast cancer stem-like cells by promoting the response to
DNA replicative stress
Takahiko Murayama1, Toyoaki Natsume2 , Tatsunori Nishimura1,
Yutaka Suzuki3 , Sumio Sugano3 , Masato Kanemaki2 , Arinobu Tojo4 ,Noriko Gotoh1

抄録 口演（２日目）(1Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University,
2
Division of Molecular Cell Engineering, National Institute of Genetics,
3
Department of Medical Genome Sciences, Graduate School of Frontier Sciences,
The University of Tokyo, 4Division of Molecular Therapy, Institute of Medical
Science, The University of Tokyo)

P-31 Identification of BCAAs metabolism pathway as a common machinery for
maintaining the stemness of human colorectal cancer
Fumiyasu Hanamura1, Yoshikane Kikushige1, Eishi Baba 2 , Koichi Akashi1

抄録（ポスター）(1Department of Medicine and Biosystemic Sciences, Kyushu University Graduate
School of Medical Sciences, 2Department of Comprehensive Clinical Oncology,
Faculty of Medical Sciences, Kyushu University)

P-32 p57 identifies quiescent stem cells in normal and neoplastic intestinal epithelia:
towards development of an eradicative cancer therapy
Takeru Oka, Tsunaki Higa, Yasutaka Okita, Keiichi I. Nakayama(Department of Molecular and Cellular Biology, Medical Institute of Bioregulation,
Kyushu University)

P-33 Identification of critical downstream molecules of FOXO for targeting leukemicstem cells
Masaya Ueno1,2 , Yusuke Takase1, Kenta Kurayoshi1, Atsushi Hirao1,2(1Cancer Research Institute, Kanazawa University, 2WPI Nano Life Science
Institute, Kanazawa University)

第 17 回幹細胞シンポジウム

122019 年 5 月 24 日（金）－25 日（土）(1Division of Hematological Malignancy, National Cancer Center, ResearchInstitute, 2Division of Stem Cell and Molecular Medicine, Center for Stem Cell
Biology and Regenerative Medicine, Institute of Medical Science, University ofTokyo)

P-35 Glioma stem like cells can be targeted in Boron Neutron Capture Therapy withboronophenylalanine
Natsuko Kondo1, Masaki Hikida 2 , Mitsutoshi Nakada3 , Yoshinori Sakurai1,
Minoru Suzuki1(1Institue for Integrated Radiation and Nuclear Science, Kyoto University,2
Department of Life Science, Akita university, 3Department of Neurosurgery,
Kanazawa university)

P-36 Incomplete rejuvenation of aged HSCs in young bone marrow niche
Wakako Kuribayashi1,2 , Motohiko Oshima 2 , Atsushi Iwama 2(1Chiba Univercity, 2The Institute of Medical Science, Tokyo Univercity)

P-37 CD244 is a sensitive marker to represent functional retardation of HSCs after invitro culture
Shuhei Koide1,2 , Valgardur Sigurdsson1, Visnja Radulovic1, Mark Garde1,
Stefan Lang3 , Kenichi Miharada1(1Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund
University, 2Division of Stem Cell and Molecular Medicine, Center for Stem Cell
Biology and Regenerative Medicine, Institute of Medical Science at University ofTokyo, 3StemTherapy Bioinformatics Core Facility, Lund Stem Cell Center, Lund
University)

P-38 Identification and local manipulation of bone marrow vasculature duringin vivo intravital imaging
Takayuki Morikawa, Keiyo Takubo

P-39 Radiation response of mammary stem and progenitor cells of Sprague-Dawley
rats as a potential target of radiation-induced carcinogenesis
Ken-ichi Kudo1, Yukiko Nishimura1, Masaru Takabatake1, Kazuhiro Daino1,
Ayaka Hosoki2 , Mayumi Nishimura1, Shizuko Kakinuma1,
Tatsuhiko Imaoka1

P-40 Allelic inactivation of Tets is responsible for leukemic transformation in micealready losing Tet functions in multiple alleles
Mamiko Sakata-Yanagimoto1, Shrestha Raksha1, Koichiro Maie1,
Motohiko Oshima 2 , Yaeko Nakajima-Takagi2 , Hirotaka Matsui3 ,Takayasu Kato1, Hideharu Muto1, Enguerran Mouly4 , Olivier A. Bernard4 ,Haruhiko Koseki5, Atsushi Iwama 2 , Shigeru Chiba1(1University of Tsukuba, 2the University of Tokyo, 3Kumamoto University,
4
INSERM U1170, 5RIKEN Research Center for Allergy and Immunology)

P-41 Investigation of the mechanisms of delayed aging and cancer resistance in thelongest-lived rodent, the naked mole-rat
Kyoko Miura(Kumamoto University, Faculty of Life Sciences)13

第 17 回幹細胞シンポジウム

抄録（ポスター）(1Department of Radiation Effects Research, National Institute of Radiological
Sciences, National Institutes for Quantum and Radiological Science andTechnology, 2Fukushima Project Headquarters, National Institute of Radiological
Sciences)

抄録 口演（２日目）(Department of Stem Cell Biology, Research Institute, National Center for Global
Health and Medicine)プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

P-34 MOZ is critical for leukemic cell proliferation and immortalization throughrepression of p16Ink4a geneTakuo Katsumoto1, Atsushi Iwama 2 , Issay Kitabayashi1

2019 年 5 月 24 日（金）－25 日（土）プログラム（１日目） プログラム（２日目） プログラム（ポスター） 抄録 口演（１日目）

P-42 Functional requirement of Ovol genes for lineage specification of mouse PGCs
Yuki Naito1, Go Nagamatsu1, Nobuhiko Hamazaki1, Makoto Hayashi2 ,Yuko Shinozuka 2 , Satoru Kobayashi2 , Katsuhiko Hayashi1

抄録 口演（２日目）

P-48 Maintenance of heterogeneous epidermal stem cell populations by the distinct
niche
Aiko Sada1, Lalhaba Oinam1, Gopakumar Changarathil1, Jun Tsunezumi2 ,Hiromi Yanagisawa1(1Kyushu University, 2Tsukuba University)

P-43 Identification of the early progenitor cell for the cardiac conduction system
Akane Sakaguchi1, Hiroki Kokubo2 , Rieko Ajima 3 , Yumiko Saga3(1BDR, Laboratory for Heart Regeneration, 2Hiroshima university, 3NIG)

P-44 Functional analysis of MeCP2, the Rett syndrome responsible factor, mediatedby microRNA in neural stem cells fate specification
Hideyuki Nakashima1, Keita Tsujimura 2 , Koichiro Irie3 , Takuya Imamura1,
Kinichi Nakashima1(1Stem Cell Biology and Medicine, Kyushu University, 2Nagoya University
Graduate School of Medicine, 3Faculty of Education and Integrated Arts andSciences, Waseda University)

P-45 Germ cell specific generation of Mga variant that may facilitate meiotic process
Yuka Kitamura, Kousuke Uranishi, Ayumu Suzuki, Masataka Hirasaki,
Masazumi Nishimoto, Akihiko Okuda(Saitama Medical University, Research Center for Genomic Medicine, Division of
Developmental Biology)

P-46 Investigation for a novel therapeutic target in acute myeloid leukemia withmonosomy 7
Kensuke Matsuda, Yuki Kagoya, Sho Yamazaki, Masashi Miyauchi,
Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine, The
University of Tokyo)

P-47 Cell competition in the growing epithelial progenitors is driven by autophagy
Rina Nagata, Mai Nakamura, Yuya Sanaki, Tatsushi Igaki(Graduate School of Biostudies, Kyoto University)(1Life Science Center for Survival Dynamics, Tsukuba Advanced Research
Alliance (TARA), University of Tsukuba, Tsukuba, Japan, 2Department of Internal
Medicine, Division of Nephrology, UT Southwestern Medical Center, Dallas, USA)抄録（ポスター）第 17 回幹細胞シンポジウム

14