May 27 (Fri.)-May 28 (Sat.), 2022

8:00

The 1st Day : Friday, May 27
Oral Presentation

The 2nd Day : Saturday, May 28
Oral Presentation

8:30~10:05

8:00

▶P.6

Session 5

9:00

9:00

Tissue stem cells
O-13~O-17

Chair : Aiko Sada

9:30~11:30（予定）

10:00

10:05~10:20

幹細胞若手の会（つくしの会）

10:20~11:25

10:00

Coffee BreakSession 6▶P.7

Microenvironment for stem cells
O-18~O-20

11:00

11:00

Chair : Atsushi Hirao
11:25~11:40

General Meeting

11:40~12:50

12:00

13:00

13:00~13:05
13:05~14:40

12:50~14:10

Opening Remarks
Session 1

14:40~14:55
14:55~16:30

13:00

O-21~O-24

O-01~O-05

14:10~14:25
14:25~15:30

Session 8

O-25~O-27▶P.4

Chair : Kyoko Miura
Daisuke Nanba
15:30~15:35

14:00

Coffee BreakAging of stem cells

Coffee BreakHematopoietic stem cells/
Hematopoietic malignancy/
Cancer stem cells 2

16:00

▶P.8

Chair : Koji Eto
Takuya Yamamoto

Chair : Issei Kitabayashi

Session 2

Session 7

Pluripotent stem cells/
clinical application of stem cells▶P.3

Hematopoietic stem cells/
Hematopoietic malignancy/
Cancer stem cells 1

14:00

15:00

12:00

Lunch Time

▶P.9

15:00

Award Announcement / Closing Remarks
16:00

O-06~O-10
Chair : Yoshikane Kikushige
16:30~16:45

17:00

16:45~17:30

Coffee BreakSession 3

Special Lecture 1

▶P.5

17:00

O-11

Chair : Yasuhiro Yamada
17:30~18:15

Session 4

Special Lecture 2

▶P.5

O-12

18:00

18:00

Chair : Atsushi Iwama
18:30~20:00

19:00

19:00

Poster Session

20:00

20:00

19th Stem Cell Research Symposium

2

May 27 (Fri.)-May 28 (Sat.), 2022

The 1st Day
13:00～13:05

Opening Remarks

Session 1: Hematopoietic stem cells/ Hematopoietic malignancy/
Cancer stem cells 1
13:05～14:40

Chair Issei Kitabayashi(National Cancer Center Research Institute)

Invited Lecture(Cancer Research Institute, Kanazawa University)

Invited Lecture

O-02（13:30～13:55）
Aberrant splicing events lead to altered cell fate of hematopoietic stem cells
Daichi Inoue
O-03（13:55～14:10）
Infection stresses initiate the transformation of pre-MDS stem cells via activation oftranscription factor Elf1
Takako Yokomizo1, Ai Hamashima1, Sho Kubota1, Mariko Morii1, Jie Bai1,
Sun Yuqi1, Mihoko Iimori1, Atsushi Iwama 2 , Hitoshi Takizawa1,
Hirotaka Matsui1, Goro Sashida1(1Kumamoto University, 2The University of Tokyo)

O-04（14:10～14:25）
Screening with Homozygous Mutant Embryonic Stem Cells to Identify a Novel Gene
Essential for Hematopoiesis
Ritsuko Nakai1, Takafumi Yokota1, Masahiro Tokunaga 2 , Takao Sudo1,
Naoki Hosen1, Junji Takeda3(1Department of Hematology and Oncology, Osaka University Graduate School of
Medicine, 2Department of Hematology, Suita Municipal Hospital, 3ResearchInstitute for Microbial Diseases, Osaka University)O-05（14:25～14:40）
Formation of microbial signal-induced innate immune memory in hematopoietic stem
cells
Nicole Pui-Yu Ho1, Alban Johansson1, Roland Huber2 , Paola Betancur3 ,Hitoshi Takizawa1,4

3

19th Stem Cell Research Symposium

Abstract / Poster(1Laboratory of Stem Cell Stress, International Research Center for Medical
Sciences (IRCMS), Kumamoto University, 2A*STAR Bioinformatics Institute,Singapore, 3University of California San Francisco, USA, 4Center for Metabolic
Regulation of Healthy Aging (CMHA), Kumamoto University)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

(Foundation for Biomedical Research and Innovation at Kobe)

Program / Poster

O-01（13:05～13:30）
FXYD3, a subunit of Na+ pump, determines the origin of triple-negative breast cancer
stem-like cells, the preeminent driver of drug resistance
Noriko Gotoh

Program / 1st Day Program / 2nd Day

Friday, May 27.

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 27 (Fri.)-May 28 (Sat.), 2022

14:40～14:55

Coffee BreakSession 2: Hematopoietic stem cells/ Hematopoietic malignancy/
Cancer stem cells 2
14:55～16:30

Chair Yoshikane Kikushige(Kyushu University)

Invited Lecture

O-06（14:55～15:20）
Expanded Common myeloid progenitor act in concert with the spleen to support
hematopoietic stem cell transplantation
Satoshi Yamazaki(University of Tsukuba)

Invited Lecture

O-07（15:20～15:45）
Thrombopoietin regulates mitochondria quality in hematopoietic stem cells
Ayako Nakamura-Ishizu(Tokyo Women’s Medical University)

O-08（15:45～16:00）
ACLY-dependent coupling of metabolic state and chromatin accessibility regulates
hematopoietic stem cell functions during bone marrow regeneration
Terumasa Umemoto1, Alban Johansson1, Shah Adil Ishtiyaq Ahmad1,
Michihiro Hashimoto2 , Sho Kubota3 , Kenta Kikuchi4 , Haruki Odaka5,
Takumi Era5, Daisuke Kurotaki4 , Goro Sashida 3 , Toshio Suda 2,6(1Laboratory of Hematopoietic Stem Cell Engineering, International ResearchCenter for Medical Sciences, Kumamoto University, 2Laboratory of Stem Cell
Regulation, International Research Center for Medical Sciences, Kumamoto
University, 3Laboratory of Transcriptional Regulation in Leukemogenesis,International Research Center for Medical Sciences, Kumamoto University,
4
Laboratory of Chromatin Organization in Immune Cell Development,International Research Center for Medical Sciences, Kumamoto University,
5
Department of Cell Modulation, Institute of Molecular Embryology and Genetics,
Kumamoto University, 6Cancer Science Institute of Singapore, National Universityof Singapore)O-09（16:00～16:15）
Hematopoietic stem cells acquire robust mitochondrial metabolic plasticity byincreasing Sdhaf1 protein levels during aging
Shintaro Watanuki, Hiroshi Kobayashi, Keiyo Takubo(National Center for Global Health and Medicine)O-10（16:15～16:30）
Fanconi Anemia-related replication stress increases metabolic activity in fetal liver
hematopoietic stem cells
Makiko Mochizuki-Kashio, Ayako Nakamura-Ishizu(Department of Microanatomy, Department of Medicine, Tokyo Women’s Medical
University)

16:30～16:45

Coffee Break

19th Stem Cell Research Symposium

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May 27 (Fri.)-May 28 (Sat.), 2022

Chair Yasuhiro Yamada(Institute of Medical Science, University of Tokyo)

O-11
Mechanism and In Vitro Reconstitution of Mammalian Germ-Cell Development
Mitinori Saitou1,2,3(1Institute for the Advanced Study of Human Biology, Kyoto University,2
Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto
University, 3Center for iPS Cell Research and Application, Kyoto University)

17:30～18:15

Session 4: Special Lecture 2

Chair Atsushi Iwama(Institute of Medical Science, University of Tokyo)(1Institute for Frontier Life and Medical Sciences, Kyoto University, 2RIKEN
Center for Brain Science)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

18:30～20:00

Poster Session

Program / Poster

O-12
Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity
Ryoichiro Kageyama1,2

Program / 1st Day Program / 2nd Day

16:45～17:30

Session 3: Special Lecture 1

Abstract / Poster

5

19th Stem Cell Research SymposiumSaturday, May 28.

The 2nd Day
8:30～10:05

Session 5: Tissue stem cells

Chair Aiko Sada

(Kumamoto University)

Invited LectureO-13（8:30～8:55）
Vasculature-dependent epidermal stem cell state organizes tissue scaling in dynamic
skinFumiko Toyoshima(Kyoto University)

Invited LectureO-14（8:55～9:20）
The Dll4−Notch2 axis regulates mechanical unloading- and metabolic
overloading-induced muscle atrophy
Yusuke Ono(Institute of Molecular Embryology and Genetics, Kumamoto University)

O-15（9:20～9:35）
Identifying a tissue stem cell subpopulation by combining single-cell morphometrics,
organoid culture, and transcriptomics
Mitsuru Morimoto1, Takashi Fujimura 2,3(1RIKEN BDR, Lab for Lung Development and Regeneration, 2RIKEN BDR,
3
Otsuka Pharmaceutical Co., Ltd.)

O-16（9:35～9:50）
Modular and defined organoid culture conditions for mouse and human lung alveolar
stem cell expansion and differentiation
Hiroaki Katsura1,2 , Yoshihiko Kobayashi1,3 , Mitsuru Morimoto2 ,Purushothama Rao Tata1(1Duke University, Department of Cell Biology, 2RIKEN BDR, Lab. for Lung
Development and Regeneration, 3Kyoto University, Institute for Frontier Life andMedical Sciences, Lab. of Tissue Homeostasis)O-17（9:50～10:05）
Reservoir of tissue-resident stem cells for regeneration of airway epithelium
Yoshihiko Kobayashi1,2 , Aleksandra Tata1, Purushothama Rao Tata1(1Department of Cell Biology, Duke University School of Medicine, 2Lab. of Tissue
Homeostasis, Institute for Life and Medical Sciences, Kyoto University)

10:05～10:20

Coffee Break

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 27 (Fri.)-May 28 (Sat.), 2022

19th Stem Cell Research Symposium

6

May 27 (Fri.)-May 28 (Sat.), 2022

10:20～11:25

Chair Atsushi Hirao(Kanazawa University)

Invited Lecture

O-18（10:20～10:45）
Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
Sa Kan Yoo(RIKEN)

Invited Lecture

O-19（10:45～11:10）
Induction of primordial germ cells from pluripotent stem cells in non-mouse mammals
Toshihiro Kobayashi1,2(1Department of Regenerative Medicine, Graduate School of Medicine, Chiba
University, Chiba, Japan, 2Combinatics Inc., Japan, 3Department of Endocrinology,
Hematology and Gerontology, Graduate School of Medicine, Chiba University,
Chiba, Japan, 4Division of Stem Cell and Molecular Medicine, Center for Stem
Cell Biology and Regenerative Medicine, The Institute of Medical Science, The
University of Tokyo, Tokyo, Japan, 5Department of Molecular Oncology, Graduate
School of Medicine, Chiba University, Chiba, Japan, 6TOKIWA-Bio, Inc., Tsukuba,
Japan)

General Meeting

11:25～11:40

Lunch Time

11:40～12:50

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-20（11:10～11:25）
Retrotransposons in macrophages trigger type I interferon dependent inflammation in
Werner syndrome
Sudip Kumar Paul1, Masamitsu Sone1, Ashwini Patil2 , Hisaya Kato3 ,Yoshiro Maezawa 3 , Motohiko Oshima4 , Masaki Fukuyo5,
Bahityar Rahmutulla5, Yasuo Ouchi1, Manami Ohtaka6 , Mahito Nakanishi6 ,Kyoko Tsujimura1, Atsushi Kaneda5, Atsushi Iwama4 , Koutaro Yokote3 ,Koji Eto1, Naoya Takayama1

Program / Poster(1Division of Mammalian Embryology, Center for Stem Cell Biology andRegenerative Medicine, The Institute for Medical Science The University ofTokyo, 2Section of Mammalian Transgenesis, Center for Genetic Analysis of
Behavior, National Institute for Physiological Sciences)

Program / 1st Day Program / 2nd Day

Session 6: Microenvironment for stem cells

Abstract / Poster

7

19th Stem Cell Research SymposiumSession 7： Pluripotent stem cells/ clinical application of stem cells

12:50～14:10

Chair Koji Eto(CiRA, Kyoto University)

Takuya Yamamoto(CiRA, Kyoto University)

Invited LectureO-21（12:50～13:15）
Modelling peri-implantation development using naïve pluripotent stem cells
Yasuhiro Takashima(Kyoto University CiRA)

Invited LectureO-22（13:15～13:40）
Regeneration of ocular tissues using human pluripotent stem cell-derived organoids
Ryuhei Hayashi(Osaka University)O-23（13:40～13:55）
The combined bone forming capability of human-induced pluripotent stem
cells-derived platelets and human bone morphogenetic proteins-2
Michiaki Mukai1,2 , Norichika Mizuki3 , Yasuhiro Shiga 3 , Kentaro Kosaka1,
Naoya Takayama1, Seiji Ohtori3 , Koji Eto1,4(1Department of Regenerative Medicine, Chiba University Graduate School of
Medicine, Chiba, Japan, 2Department of Orthopaedic Surgery, Chiba University
Graduate School of Medicine, Chiba, Japan, 3Department of Orthopedic Surgery,
Graduate School of Medicine, Chiba University, 4Department of ClinicalApplication, Center for iPS Cell Research and Application (CiRA), Kyoto
University, Kyoto, Japan)

O-24（13:55～14:10）
Elucidating the immune escape mechanisms of HLA-KO iPSC-platelets from NK cells
Charlotte Flahou1, Mio Iwasaki1, Akitsu Hotta1, Hitoshi Takizawa 2 ,Naoshi Sugimoto1, Koji Eto1

(1Department of Clinical Application, Center for iPS Cell Research and Application(CiRA), Kyoto University, Kyoto, Japan, 2International Research Center for Medical
Sciences (IRCMS), Kumamoto University, Kumamoto, Japan)

14:10～14:25

Coffee Break

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 27 (Fri.)-May 28 (Sat.), 2022

19th Stem Cell Research Symposium

8

May 27 (Fri.)-May 28 (Sat.), 2022

Chair Kyoko Miura(Kumamoto University)

Daisuke Nanba(Institute of Medical Science, University of Tokyo)

Invited LectureO-25（14:25～14:50）
Investigation of the mechanisms underlying longevity and cancer-resistance in the
naked mole-rat
Kyoko Miura(Faculty of Life Sciences, Kumamoto University)

Invited LectureO-27（15:15～15:30）
MLKL mediates inflammation-induced attrition and aging-associated functional decline
in hematopoietic stem cells
Yuta Yamada, Jingjing Yang, Masayuki Yamashita, Atsushi Iwama(Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology andRegenerative Medicine, The Institute of Medical Science, The University of Tokyo)

Award Announcement / Closing Remarks

15:30～15:35

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

(1Division of Aging and Regeneration, The Institute of Medical Science, The
University of Tokyo, 2Department of Dermatology, Ehime University School of
Medicine, 3Department of Plastic and Reconstructive Surgery, International
University of Health and Welfare, School of Medicine, 4Research Center for
Nuclear Physics (RCNP), Osaka University)

Program / Poster

O-26（14:50～15:15）
EGFR-mediated epidermal stem cell motility drives skin regeneration through
COL17A1 proteolysis
Daisuke Nanba1, Fujio Toki1, Kyosuke Asakawa1, Hiroyuki Matsumura1,
Ken Shiraishi2 , Koji Sayama 2 , Kyoichi Matsuzaki3 , Hiroshi Toki4 ,Emi Nishimura1

Program / 1st Day Program / 2nd Day

14:25～15:30

Session 8: Aging of stem cells

Abstract / Poster

9

19th Stem Cell Research SymposiumAbstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 27 (Fri.)-May 28 (Sat.), 2022

Poster Session
P-01 HMGA1 is upregulated in leukemic stem cell fraction of myelodysplastic
syndromes and blocks normal differentiation of hematopoietic cells
Kazutoshi Ebisawa1, Yosuke Masamoto1, Mineo Kurokawa1,2(1Department of Hematology & Oncology, Graduate School of Medicine, The
University of Tokyo, 2Department of Cell Therapy and Transplantation Medicine,
The University of Tokyo Hospital)

P-02 Investigating the function of Rasip1 in HSC-containing IAHCs of midgestation
mouse embryos
Gerel Melig1, Ikuo Nobuhisa1,2 , Kiyoka Saito1, Ryota Tsukahara1,
Ayumi Itabashi1, Yoshiakira Kanai3 , Masami Kanai-Azuma4 , Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU), 2Department of Nutritional Science, Faculty of
Nutritional Sciences, Nakamura Gakuen University, 3Department of Veterinary
Anatomy, Graduate School of Agricultural and Life Science, University of Tokyo,
4
Department of Experimental Animal Model for Human Disease, Center for
Experimental Animal, Tokyo Medical and Dental University (TMDU))

P-03 DNMT3B contributes to the stemness of left-sided colorectal cancer derived
from patients
Ryosuke Taguchi1, Taichi Isobe2 , Yoshikane Kikushige3 , Shohei Ueno1,
Kenji Tsuchihashi4 , Hiroshi Ariyama4 , Koichi Akashi1, Eishi Baba 2(1Department of Medicine and Biosystemic Science, Graduate School of Medical
Sciences, Kyushu University, 2Department of Oncology and Social Medicine,
Graduate School of Medical Sciences, Kyushu University, 3Center for Cellular andMolecular Medicine, Kyushu University Hospital, 4Department of Hematology,
Oncology and Cardiovascular Medicine, Kyushu University Hospital)

P-04 Expanded CMPs act in concert with the spleen and support early hematopoietic
recoveryTakao Yogo1, Hans Jiro Becker2 , Satoshi Yamazaki2,3(1Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative
Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo,
Japan, 2Laboratory of Stem Cell Therapy, Faculty of Medicine, University ofTsukuba, Ibaraki, Japan, 3Division of Stem Cell Biology, Center for Stem Cell
Biology and Regenerative Medicine, The Institute of Medical Science, The
University of Tokyo, Tokyo, Japan)

P-05 5-methylcytosine hydroxylase Tet3 endows embryonic neural stem/precursor
cells with astrogliogenic competence
Norihisa Bizen1,2 , Toshinobu Nakamura 3 , Tetsuya Taga1(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU), Tokyo, Japan, 2Division of Neurobiology andAnatomy, Graduate School of Medical and Dental Sciences, Niigata University,
Niigata, Japan, 3Laboratory for Epigenetic Regulation, Department of Bio-Science,
Nagahama Institute of Bio-Science and Technology, Shiga, Japan)

P-06 Exogenous serine is required for robust proliferation of human mesenchymal
stem cells
Hiroaki Matsuda1, Satoru Miyagi1, Kenichi Miyamoto1, Hiromi Miyauchi2 ,Takashi Suyama1,2 , Yuko Kato1,2 , Takeshi Taketani3 , Yumi Matsuzaki1,2(1Department of Life Science, Faculty of Medicine, Shimane University, Izumo
City, Shimane, Japan, 2PuREC Co., Ltd., Izumo City, Shimane, Japan, 3Departmentof Pediatrics, Faculty of Medicine, Shimane University, Izumo City, Shimane,
Japan)

19th Stem Cell Research Symposium

10

May 27 (Fri.)-May 28 (Sat.), 2022

(1QST National Institute of Radiological Sciences, 2National Institute of Technology
Kure College, 3QST Institute for Quantum Life Science, 4Fukushima Medical
University)

P-08 Persistent suppression of the luminal progenitor cell differentiation precedes
radiation-induced rat mammary carcinogenesis
Kento Nagata1, Mayumi Nishimura1, Kazuhiro Daino1, Daisuke Iizuka1,
Yukiko Nishimura1, Yuya Hattori2 , Ritsuko Watanabe3 , Akinari Yokoya3 ,Shizuko Kakinuma1, Tatsuhiko Imaoka1

P-09 Mechanism of suppression of mammary cell clonal expansion by radiation
exposure: possible involvement of cellular senescence
Daisuke Iizuka, Mayumi Shinagawa, Mari Ogawa, Chizuru Tsuruoka,
Masaaki Sunaoshi, Tatsuhiko Imaoka, Shizuko Kakinuma(Dept. Radiat Effects Res, Nat Inst Radiol Sci, QST)

(Dept Radiat Effects Res, NIRS, QST)

P-11 Clonal dynamics in the murine male germline from primordial germ cells tospermatogonial stem cells, and the next generation
Tatsuro Ikeda1, Maurice Langhinrichs2,3 , Tamar Nizharadze2,3 ,Hans-Reimer Rodewald2,3 , Thomas Höfer2,3 , Shosei Yoshida1,4(1NIBB, 2DKFZ, 3Uni Heidelberg, 4 SOKENDAI)

P-12 Generation of novel mouse models regulating KRAS/MAPK/ERK signaling inthe spatiotemporal manner in vivo
Nao Sankoda, Kohei Nagata, Fumie Nakasuka, Takayuki Yasuda,
Yasuhiro Yamada(Institute of Medical Science, University of Tokyo)

P-13 Generation of a transgenic mouse strain that expresses CreERT andfluorescent protein under the transcriptional control of the Fzd5 locus
Satoru Miyagi1, Yuko Kato1,2 , Ayako Watanabe1, Kenichi Miyamoto1,
Rintaro Yoshikawa1, Yumi Matsuzaki1,2(1Department of Life Science, Faculty of Medicine, Shimane University, 2PuREC
Co., Ltd.)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-10 Genomic mutation analysis of precancerous lesions in radiation-induced
medulloblastoma
Chizuru Tsuruoka, Takamitsu Morioka, Mutsumi Kaminishi,
Mayumi Shinagawa, Shizuko Kakinuma

Program / Poster(1Department of Radiation Effects Research, National Institute of Radiological
Sciences, National Institutes for Quantum Science and Technology, 2Department
of Electrical Engineering and Information Science, National Institute ofTechnology Kure College, 3Institute for Quantum Life Science, National Institutes
for Quantum Science and Technology)

Program / 1st Day Program / 2nd Day

P-07 Understanding the mechanism of radiation dose rate dependence in mammary
carcinogenesis: integration of stem cell and mathematical biology
Tatsuhiko Imaoka1, Kento Nagata1, Yuya Hattori2 , Ritsuko Watanabe3 ,Akinari Yokoya3 , Ken-ichi Kudo4 , Mayumi Nishimura1, Kazuhiro Daino1,
Daisuke Iizuka1, Yukiko Nishimura1

Abstract / Poster

11

19th Stem Cell Research SymposiumAbstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 27 (Fri.)-May 28 (Sat.), 2022

P-14 Identification of a niche-mimicking synthetic polymer scaffold that maintains
neural stem cells in a growth factor- and serum-free system
Tetsuya Taga1, Norihisa Bizen1,2 , Kouichi Tabu1, Mei Wu3 ,Christian Mangani3 , Rong Zhang3 , Mark Bradley3(1Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU), 2Division of Neurobiology and Anatomy, Graduate
School of Medical and Dental Sciences, Niigata University, 3EaStChem, School ofChemistry, University of Edinburgh)

P-15 Hepatocyte growth factor is an adipokine that enhances breast cancer stem
cell properties
Behnoush Khaledian1, Masahiro Mizuno1, Masao Maeda1,
Takanori Hayashi1, Seiya Mizuno2 , Seiji Okada3 , Motoshi Suzuki1,
Naoya Asai1, Fumihiro Sugiyama 2 , Satoru Takahashi2 , Yohei Shimono1(1Fujita Health University School of Medicine, 2Faculty of Medicine, University ofTsukuba, 3Joint Research Center for Human Retrovirus Infection, Kumamoto
University)

P-16 Mesenchymal loss of p53 alters stem cell capacity and models humanfibrosarcoma
Yuriko Sorimachi1,2 , Hiroshi Kobayashi1, Nobuhito Goda 2 , Keiyo Takubo1(1Department of Stem Cell Biology, Research Institute, National Center for Global
Health and Medicine, 2Department of Life Sciences and Medical BioScience,
Waseda University School of Advanced Science and Engineering)

P-17 Efficacy of iPSC-derived megakaryocytes and platelets for skin wound healing
Kentaro Kosaka1,2 , Naoya Takayama1, Nobuyuki Mitsukawa 2 , Koji Eto1
(1Department of Regenerative Medicine, Chiba University Graduate School of
Medicine, 2Department of Plastic and Reconstructive Surgery, Chiba University
Graduate School of Medicine)

P-18 Establishment of mouse stem cells that can recapitulate the developmental
potential of primitive endoderm
Yasuhide Ohinata1, Haruhiko Koseki2,3(1Laboratory for Cellular and Molecular Medicine, Graduate School of Medicine,
Chiba University, 2Laboratory for Developmental Genetics, RIKEN Center for
Medical Sciences (IMS), 3Cellular and Molecular Medicine, Graduate School of
Medicine, Chiba University)

P-19 An interferon-γ/FLT3 axis positively regulates hemopoietic progenitor cell
expansion from human pluripotent stem cells
Kenji Kitajima1, Minako Shingai1,2 , Hikaru Ando1,2 , Takahiko Hara1,2,3(1Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, 2Graduate
School of Medical and Dental Sciences, Tokyo Medical and Dental University,
3
Graduate School of Science, Department of Biological Science, Tokyo Metropolitan
University)

P-20 Clu-positive hematopoietic stem cells show decreased stemness and expand thenumber with aging
Shuhei Koide1, Motohiko Oshima1, Akira Nishiyama 2 , Koichi Murakami2,3 ,Naoki Itokawa1, Zhiqian Zheng1, Yaeko Nakajima-Takagi1,
Tomohiko Tamura 2,3 , Atsushi Iwama1(1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology andRegenerative Medicine, The Institute of Medical Science, The University of Tokyo,
Tokyo, Japan, 2Department of Immunology, Yokohama City University Graduate
School of Medicine, Yokohama, Japan, 3Advanced Medical Research Center,
Yokohama City University, Kanagawa, Japan)

19th Stem Cell Research Symposium

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May 27 (Fri.)-May 28 (Sat.), 2022

(1Department of Aging and Longevity Research, Faculty of Life Sciences,
Kumamoto University, Japan, 2Division of Gene Regulation, Institute for Advanced
Medical Research, Keio University School of Medicine, Japan)

P-22 MYCL-mediated reprogramming expands pancreatic insulin-producing cells
Michitada Hirano, Yasuhiro Yamada(Division of Stem Cell Pathology, Center for Experimental Medicine and Systems
Biology, Institute of Medical Science, University of Tokyo)

Program / 1st Day Program / 2nd Day

P-21 Characterization of neural stem/progenitor cells in the subventricular zone of
the naked mole-rat brain
Yuki Yamamura1, Yoshimi Kawamura1, Yuki Oiwa1, Kaori Oka1,
Nobuyuki Onishi2 , Hideyuki Saya 2 , Kyoko Miura1

Program / Poster
Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)
Abstract / Poster

13

19th Stem Cell Research Symposium