May 20 (Fri)-May 21 (Sat), 2016

The 1st Day

Opening Remarks Organizer Atsushi Hirao

13:00～13:10(Cancer Research Institute, Kanazawa University)

13:10～15:05

Session 1: Hematopoietic Stem Cells

Chair Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine, The University ofTokyo)

Atsushi Iwama(Department of Cellular and Molecular Medicine, Chiba University)(Laboratory of Stem Cell Therapy, Center for Experimental Medicine, The
Institute of Medical Science, the University of Tokyo)(1Research Center for Regenerative Medicine, Tokai University School of Medicine,2
Molecular Medicine and Therapy, Tohoku University Graduate School of
Medicine)

O-3 A metabolic signal that awakens resting hematopoietic stem/progenitor cells
Keiyo Takubo(Department of Stem Cell Biology, Research Institute, National Center for Global
Health and Medicine)

O-4 Enhancer for Runx1, eR1: a powerful tool in stem cell and cancer biology
Motomi Osato1,2 , Cai Ping Koh1, Tomomasa Yokomizo2(1Cancer Science Institute, National University of Singapore, 2International
Research Center for Medical Sciences, Kumamoto University)

O-5 Pot1 maintains hematopoietic stem cell activity under stress
Fumio Arai

(Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University)

Coffee Break

15:05～15:25

Session 2: Tissue Stem Cells

15:25～17:20(Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and
Dental University (TMDU))

Emi Nishimura(Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental
University)

3

14th Stem Cell Research Symposium

Abstract / Poster

Chair Tetsuya Taga

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-2 TGF-beta-induced intracellular PAI-1 is a critical regulator of hematopoietic
stem cell localization in the niche
Takashi Yahata1, Abd Aziz Ibrahim1, Yukari Muguruma1, Satoko Kaneko1,
Toshio Miyata 2 , Kiyoshi Ando1

Program / Poster

O-1 Standard medium leads to high reproducible results of HSCs via removal of
non-scientific factors.
Satoshi Yamazaki

Program / 1st Day Program / 2nd Day

Friday, May 20.

O-6 Hair follicle aging is driven by COL17A1 proteolysis
Hiroyuki Matsumura1, Yasuaki Mohri1, Hironobu Morinaga1,
Makoto Fukuda1, Sotaro Kurata 2 , Emi K. Nishimura1(1Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical
and Dental University, 2Beppu Garden-Hill Clinic, Kurata Clinic, Beppu city, Oita)

O-7 Locus-specific expansion of Polycomb domain determines the temporal
repression of the neurogenic genes in neocortical development
Yusuke Kishi1, Yusuke Hirabayashi2 , Kelsey Tyssowski2 , Haruhiko Koseki3 ,Yutaka Suzuki4 , Yukiko Gotoh1(1Graduate School of Pharmaceutical Sciences, the University of Tokyo, 2Instituteof Molecular and Cellular Biosciences, the University of Tokyo, 3RIKEN Center
for Allergy and Immunology, 4Department of Medical Genome Sciences, theUniversity of Tokyo)

O-8 Oscillatory Control of Determination Factors for Multipotency versus Fate
Choice in Neural Stem Cells
Itaru Imayoshi(Institute for Virus Research, Kyoto University)

O-9 Alternative cell fate selection and following directed cell migration coordinate
epithelial pattern of branching airways
Mitsuru Morimoto(RIKEN Center for Developmental Biology)

O-10 Regulation of stem cell properties in liver development
Atsushi Suzuki(Division of Organogenesis and Regeneration, Medical Institute of Bioregulation,
Kyushu University)

Coffee Break

17:20～17:30

Special Lecture 1

17:30～18:15

Chair Yukiko Gotoh(Laboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences, The
University of Tokyo)

S-1 “Regenerative Medicine and Disease Modeling with iPS cells
technologies”.
Hideyuki Okano(Keio University School of Medicine)

18:45～

Poster Session and Reception

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 20 (Fri)-May 21 (Sat), 2016

14th Stem Cell Research Symposium

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May 20 (Fri)-May 21 (Sat), 2016

The 2nd Day
8:30～9:50

Session 3: Leukemia Stem Cells

Chair Shigeru Chiba(Department of Hematology, Faculty of Medicine, University of Tsukuba)

Yoshihiro Takihara(Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine,
Hiroshima University)

O-11 Nutrient Supply Essential for the Maintenance of CML Stem Cells
Kazuhito Naka1, Yoshihiro Takihara1, Yukio Kato2 , Hiromitsu Nakauchi3,4 ,Akira Ooshima 5, Seong-Jin Kim5

(1Kobe Univ Hospital, Dept of Transfusion Med and Cell Therapy, 2Kobe Univ
Hospital, Dept of Medical Oncology and Hematology, 3Japanese Red Cross Nagoya
the 1st Hospital, Dept of Hematology)

O-13 The role of Runx-F2r pathway in myeloid leukemia stem cells
Susumu Goyama1, Toshio Kitamura1, Joseph S. Palumbo2 , James C. Mulloy2(1Division of Cellular Therapy, The Institute of Medical Science, The University ofTokyo, 2Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital
Medical Center)O-14 Identification of TIM-3 as a functional leukemic stem cell surface molecule inprimary human myeloid leukemia
Yoshikane Kikushige, Koichi Akashi(Medicine and Biosystemic Science, Kyushu University Graduate School of Medical
Sciences)

Coffee Break

9:50～10:05

Session 4: Differentiation and Malignancy

10:05～11:35

Chair Issay Kitabayashi(Division of Hematological Malignancy, National Cancer Center Research Institute)(Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine)5

14th Stem Cell Research Symposium

Abstract / Poster

Yohei Shimono

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-12 NANOG expression as a responsive biomarker during treatment with
Hedgehog signal inhibitor in acute myeloid leukemia
Yosuke Minami1, Seiji Kakiuchi2 , Nobuaki Fukushima 3

Program / Poster(1Department of Stem Cell Biology, Research Institute for Radiation Biology andMedicine, Hiroshima University, 2Faculty of Pharmacy, Institute of Medical,
Pharmaceutical and Health Sciences, Kakuma-machi, Kanazawa University,
3
Division of Stem Cell Therapy, Center for Stem Cell Biology and Regeneration
Medicine, Institute of Medical Science, University of Tokyo, 4Institute for Stem
Cell Biology & Regenerative Medicine, Stanford University School of Medicine,CA, USA., 5CHA Cancer Institute and Department of Biomedical Science, CHA
University, Republic of Korea.)

Program / 1st Day Program / 2nd Day

Saturday, May 21.

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 20 (Fri)-May 21 (Sat), 2016

O-15 Double inactivation of Tet2 and Tet3 induces hypomethylating agent-sensitive
acute myeloid leukemia
Koichiro Maie1, Mamiko Sakata-Yanagimoto1, Motohiko Ohshima 2 ,Takayasu Kato1, Hideharu Muto1, Atsushi Iwama 2 , Shigeru Chiba1(1Department of Hematology, University of Tsukuba, 2Department of Cellular andMolecular Medicine, Graduate School of Medicine, Chiba University)

O-16 Ezh2 loss in hematopoietic stem cells predisposes mice to develop
heterogeneous malignancies in an Ezh1-dependent manner
Makiko Mochizuki-Kashio1,2 , Kazumasa Aoyama 3 , Goro Sashida4 ,Motohiko Oshima 3 , Changshan Wang5, Atsushi Iwama 3(1Laboratory of Chromatin Metabolism and Epigenetics, Graduate school of
Science, 2 Department of Cellular and Molecular Medicine, Graduate school of
Medicine, Chiba University, 3Department of Cellular and Molecular
Medicine,Graduate school of Medicine, Chiba University, 4International ResearchCenter for Medical Sciences, Kumamoto University, 5College of Life Sciences,
Inner Mongolia University, China)

O-17 Therapeutic strategies for osteosarcoma stem cells by regulating adipocyte
differentiation based on actin dynamics
Hiroyuki Nobusue1, Nobuhiro Takahashi1, Nobuyuki Onishi1,
Takatsune Shimizu2 , Eiji Sugihara1, Yoshinao Oki3 , Tatsuyuki Chiyoda1,
Koichi Akashi4 , Koichiro Kano3 , Hideyuki Saya1(1Division of Gene Regulation, Institute for Advanced Medical Research, Keio
University School of Medicine, 2Department of Pathophysiology, Hoshi University,
3
Laboratory of Cell and Tissue Biology, College of Bioresource Sciences, Nihon
University, 4Department of Medicine and Biosystemic Science, Kyushu University
Graduate School of Medical Science)

O-18 DISSECTING CANCER BIOLOGY WITH iPSC TECHNOLOGY
Yasuhiro Yamada(Laboratory of Stem Cell Oncology, Department of Life Science Frontiers, Center
for iPS Cell Research and Application, Kyoto University)

Coffee Break

11:35～11:45

Special Lecture 2

11:45～12:30

Chair Takashi Shinohara(Department of Molecular Genetics, Graduate School of Medicine, Kyoto University)

S-2 The Case for Predetermination of Spermatogonial Stem Cells
John R. McCarrey1, Christopher B. Geyer2, Jon M. Oatley3,
Brian P. Hermann1(1Department of Biology, University of Texas at San Antonio, San Antonio, TX,
USA, 2Department of Anatomy and Cell Biology, East Carolina University,
Greenville, NC, USA, 3School of Molecular Biosciences, Washington State
University, Pullman, WA, USA)

Lunch Time

12:30～13:30

General Meeting

13:30～13:40

Chief Director

Koichi Akashi(Department of Medicine and Biosystemic Science, Faculty of Medicine, Kyushu
University)

14th Stem Cell Research Symposium

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May 20 (Fri)-May 21 (Sat), 2016

Chair Koji Eto(Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto
University)

Shinji Masui(CiRA, Kyoto University)

O-19 Overlapped function of Klf family members to maintain pluripotency of mouseembryonic stem cells
Hitoshi Niwa
(Institute of Molecular Embryology and Genetics, Kumamoto University)(1Department of Systems Medicine, Mitsunada Sakaguchi Laboratory, Keio
University School of Medicine, 2Kazusa DNA Research Institute, 3DNA Chip
Research Inc., 4Department of Reproductive Biology, National Center for Child
Health and Development, 5Xcoo, Inc.)(RIKEN CDB, Laboratory for in vitro Histogenesis)O-22 Identifying the biphasic role of Calcineurin/NFAT signaling pathway enables
successfully to replace sox2 in somatic cell reprogramming.
Sherif Khodeer, Takumi Era(Department of Cell Modulation, Institute of Molecular Embryology and Genetics,
Kumamoto University)

O-23 Ribosomes convert human fibroblasts into multipotent cells
Kunimasa Ohta

(Department of Developmental Neurobiology, Kumamoto University Graduate
School of Life Sciences)

15:30～15:40

Closing Remarks

Next Organizer Atsushi Iwama(Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba
University)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

O-21 Toward understanding the immortal trait of human embryonic stem cells
Masatoshi Ohgushi

Program / Poster

O-20 Large-scaled transgene activation on human embryonic stem cells
Yuhki Nakatake1, Nana Nohtomi-Chikazawa1, Miyako Murakami1,
Chiaki Ookura1, Miki Sakota1, Shunichi Wakabayashi1, Siu San Mak1,
Martin Jakt1, Tomoo Ueno1, Misako Matsushita1, Mayumi Oda1,
Noriko Utsumi2 , Madoka Hirayama-Ishikawa 3 , Noriko Itoh3 ,Motohiko Tanino3 , Yukari Ikeda3 , Hiroshi Iijima 3 , Takumi Miura4 ,Masakazu Machida4 , Kahori Minami4 , Shigeru Ko1, Hiroyuki Nishimura5,
Ryo Matoba 3 , Hidenori Akutsu4 , Osamu Ohara 2 , Minoru Ko1

Program / 1st Day Program / 2nd Day

13:40～15:30

Session 5: Pluripotent Stem Cells

Abstract / Poster

7

14th Stem Cell Research SymposiumAbstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 20 (Fri)-May 21 (Sat), 2016

Poster Session
P-1

Endothelial antigen ESAM is a human HSC marker associated with a subset ofhuman leukemias
Tomohiko Ishibashi1, Takafumi Yokota1, Hirokazu Tanaka2 , Michiko Ichii1,
Takao Sudo1, Yusuke Satoh1,3 , Yukiko Doi1, Tomoaki Ueda1,
Akira Tanimura1, Yuri Hamanaka1, Sachiko Ezoe1, Hirohiko Shibayama1,
Kenji Oritani1, Yuzuru Kanakura1(1Department of Hematology and Oncology, Osaka University Graduate School of
Medicine, 2Department of Hematology and Rheumatology, Kinki University
Faculty of Medicine, 3Department of Lifestyle Studies, Kobe Shoin Women’s
University)

P-2

Disruption of Tsukushi leads to hydrocephalus by aberrant neurogenesis.
Naofumi Ito1, Riyadh Asrafuzzaman1, Ayako Ito1, Yohei Shinmyo2 ,Athary Felemban1, Jun Hatakeyama3 , Kenji Shimamura 3 ,Kazunobu Sawamoto4 , Kunimasa Ohta1(1Department of Developmental Neurobiology, Kumamoto University, 2Departmentof Biophysical Genetics, Kanazawa University, 3Department of Brain
Morphogenesis, Kumamoto University, 4Department of Developmental andRegenerative Biology, Nagoya City University)

P-3

A single miRNA rescues EBF1 deficiency in B cell development though TGF- β
pathway
Ryutaro Kotaki1, Ai Kotani1,2(1Division of Hematological Malignancy, Institute of Medical Science, Tokai
University, 2Department of Hematology/Oncology, School of Medicine, Tokai
University)

P-4 Mechanism of epidermal aging
Nan Liu, Hiroyuki Matsumura, Makoto Fukuda, Aki Takada,
Daisuke Nanba, Emi K Nishimura(Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and
Dental University)

P-5 Kinetic analysis and modeling for understanding human keratinocyte stem/
progenitor cell behavior in epidermal sheet formation
Daisuke Nanba1, Fujio Toki1, Hiroshi Toki2 , Emi K. Nishimura1(1Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical
and Dental University, 2Research Center for Nuclear Physics, Osaka University)

P-6 Human bone marrow-derived CD271+SSEA-4 + mesenchymal stromal cells
support hematopoietic stem/progenitor cells through the cell-cell contact
Yoshikazu Matsuoka1, Keisuke Sumide1, Hiroshi Kawamura1,2 ,Ryusuke Nakatsuka1, Tatsuya Fujioka1, Yutaka Sasaki1, Yoshiaki Sonoda1(1Department of Stem Cell Biology and Regenerative Medicine, Kansai Medical
University, 2Department of Orthopedic Surgery, Kansai Medical University)

P-7

G0 phase analysis of hematopoietic stem cells in mVenus-p27K-mice
Tsuyoshi Fukushima(The Institute of Medical Science Division of cell therapy)

P-8

Regulation of physical environment for stem cell fate determination during
brain development
Yoichi Kosodo, Misato Iwashita(Korea Brain Research Institute)

14th Stem Cell Research Symposium

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May 20 (Fri)-May 21 (Sat), 2016

(1RIKEN IMS Laboratory for Stem Cell Competency, 2 Keio University School of
Medicine, 3Tokyo Medical and Dental University)

P-10 Effect of low dose-rate irradiation on the hematopoietic system
Yoshinori Ohno1, Kyoko Suzuki-Takedachi1, Mimoko Santo1, Yun Guo2 ,Masamoto Kanno2 , Shin’ichiro Yasunaga 3 , Motoaki Ohtsubo4 ,Kazuhito Naka1, Yoshihiro Takihara1(1Dept. Stem Cell Biol., RIRBM, Hiroshima Univ., 2Dept. Immunol., Grad. Sch.
Biomed. Sci., Hiroshima Univ., 3Dept. Biochem., Facul. Med., Fukuoka Univ., 4Dept.
Food and Ferment. Sci., Beppu Univ.)(1Laboratory of Cell Growth and Differentiation, Institute of Molecular andCellular Biosciences, The University of Tokyo, 2Department of Stem Cells andHuman Disease Models, Research Center for Animal Life Science, Shiga
University of Medical Science)(Laboratory of Molecular Embryology, Yokohama City University)

P-13 The DGCR8 gene, a candidate gene for 22q11.2 deletion-associatedschizophrenia, regulates adult hippocampal neurogenesis and cognition
Yasuo Ouchi(Division of Innate Immune Regulation, International Research and Development
center for Mucosal Vaccine The Institute of Medical Science, The University ofTokyo)

P-14 Mechanism of maintaining hematopoietic stem and progenitor cell phenotype
of intra-aortic cell clusters in the AGM region through the Sox17-Notch1-Hes1
axis
Kiyoka Saito, Ikuo Nobuhisa, Maha Anani, Kaho Harada,
Satomi Takahashi, Tetsuya Taga

(Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU))

P-15 MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural
StemCells
Jun Tsuyama1, Jens Bunt2 , Linda Richards2 , Hiroko Iwanari3 ,Yasuhiro Mochizuki3 , Takao Hamakubo3 , Takuya Shimazaki1,
Hideyuki Okano1

914th Stem Cell Research Symposium

Abstract / Poster(1Department of Physiology, Keio University School of Medicine, 2Queensland
Brain Institute, The University of Queensland, 3Department of Quantitative
Biology and Medicine, Research Center for Advanced Science and Technology,
The University of Tokyo)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-12 The analyses of Notch signaling in mouse testis.
Ryu Okada, Megumi Fujimagari, Tomohisa Watanabe, Akiko Kumano,
Yukio Nishina

Program / Poster

P-11 The transcription factor Klf5 regulates biliary epithelial tissue growth inliver regeneration upon cholestatic injury
Hajime Okada1, Tohru Itoh1, Kota Kaneko1, Kenji Kamimoto1,
Len Katsumata1, Minami Yamada1, Cindy Kok1, Masatsugu Ema 2 ,Atsushi Miyajima1

Program / 1st Day Program / 2nd Day

P-9 Functional recovery of age-related disorders in multiple tissues by
upregulation of a regenerative factor derived from MSCs
Hayato Naka-Kaneda1, Daisuke Hisamatsu1,2 , Shiho Nakamura1,
Yo Mabuchi3

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 20 (Fri)-May 21 (Sat), 2016

P-16 Aging of bone marrow environments influence the functions of hematopoietic
stem cells
Yasufumi Uehara, Yuya Kunisaki(Center for cellular and Molecular Medicine, Kyushu University Hospital)

P-17 Integrin α v β 3 regulates long-term repopulating activity of hematopoietic
stem cells through the double-edged influences.
Terumasa Umemoto1, Yu Matsuzaki1, Junichi Furusawa 2 ,Takayuki Yoshimoto2 , Masayuki Yamato3 , Toshio Suda4,5(1International Research Center for Medical Science (IRCMS), Kumamoto
University, 2Institute of Medical Science, Tokyo Medical University., 3Institute ofAdvanced Biomedical Engineering and Science, Tokyo Women’s medical
University., 4International Research Center for Medical Science (IRCMS),
Kumamoto University, 5 Cancer Science Institute of Singapore, National Universityof Singapore)

P-18 Does hemogenic endothelium exist in the mouse embryonic head?
Tomomasa Yokomizo1,2 , Kazuhide Iizuka 2 , Naoki Watanabe2 ,Yosuke Tanaka3 , Motomi Osato1,4 , Tomoiku Takaku2 , Norio Komatsu2(1International Research Center for Medical Sciences, Kumamoto University,2
Department of Hematology, Juntendo University School of Medicine, 3Center for
Developmental Biology, RIKEN Kobe, 4Cancer Science Institute of Singapore,
National University of Singapore)

P-19 The new BMP down-stream molecule ANKS1B is controlling Histone H3
methylation with abnormal BMP signaling in reprogramming and diseases.
Makoto Hamasaki1, Takayuki Kiboku1, Minami Soga1, Naoki Shinojima 2 ,Hirokazu Furuya3 , Takumi Era1

(1Department of Cell Modulation, Institute of Molecular Embryology and Genetics,
Kumamoto University, 2Department of Neurosurgery, Graduate School of Medical
Sciences, Kumamoto University, 3Department of Neurology, Kochi Medical School,
Kochi University)

P-20 Disease specific iPSCs mimic their disease specific phenotypes in teratomas
Takayuki Kiboku1, Makoto Hamasaki1, Saori Ikeda1, Katsuhiko Sekimata 2 ,Hirokazu Furuya3 , Hashizume Yoshinobu4 , Takumi Era1

(1Department of Cell Modulation, Institute of Molecular Embryology and Genetics,
Kumamoto University, 2RIKEN Center for Life Science Technologies, Division of
Bio-Function Dynamics Imaging, Drug Discovery Chemistry Platform Unit,
3
Department of Neurology, Kochi Medical School, Kochi University, 4RIKEN
Program for Drug Discovery and Medical Technology Platforms)

P-21 Identification of Runx1-direct targets important for definitive hematopoiesis
Yosuke Tanaka1,2 , Vicki Moignard2 , Adam Wilkinson2 , Toshio Kitamura 3 ,Bertie Gottgens2(1The University of Tokyo Institute of Medical Science Division of Cellular
Therapy, 2Cambridge University Department of Hematology Cambridge Institutefor Medical Research, 3The University of Tokyo Institute of Medical Science
Division of Cellular Therapy)

P-22 Investigation of causative genes in chronic myelomonocytic leukemia throughpatient-derived induced pluripotent stem cells
Sho Yamazaki, Kazuki Taoka, Shunya Arai, Masashi Miyauchi,
Keisuke Kataoka, Akihide Yoshimi, Mineo Kurokawa(Department of Hematology and Oncology, Graduate School of Medicine, The
University of Tokyo)

14th Stem Cell Research Symposium

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May 20 (Fri)-May 21 (Sat), 2016

(1Japan Agency for Medical Research and Development, 2National Institute of
Health Sciences, 3Pharmacological Evaluation Institute of Japan)

P-24 Formation of vascular network structures in the co-culture with humaninducible pluripotent stem cell-derived CD31+ cells
Shinako Masuda, Katsuhisa Matsuura, Mie Anazawa, Tatsuya Shimizu,
Teruo Okano(Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s
Medical University)

P-25 β -actin regulates reprogramming
Shinji Masui, Takashi Ikeda, Akitsu Hotta(CiRA, Kyoto University)

Program / 1st Day Program / 2nd Day

P-23 Development of high-efficient differentiation protocols from human iPS cells to
glutamatergic or GABAergic neural progenitor cells
Yusuke Kubo1,2,3 , Shigeru Yamada 2 , Takashi Inutsuka3 , Yasunari Kanda 2 ,Yuko Sekino2

P-26 Challenge of “HLA omnipotent platelets” for overcoming allogeneic immune
response using induced Pluripotent Stem Cell (iPSC) technology
Daisuke Suzuki1, Naoshi Sugimoto1, Norihide Yoshikawa1, Sou Nakamura1,
Hiroshi Endo1, Akitsu Hotta 2 , Koji Eto1

Program / Poster

P-27 Novel tools for generation, purification, and analysis of pluripotent stem cell–
derived cardiomyocytes
Rumi Tanaka

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

(1Department of Clinical Application, Center for iPS Cell Research and Application,
Kyoto University, 2Department of Life Science Frontiers, Center for iPS Cell
Research and Application, Kyoto University)(Miltenyi Biotec K.K.)

P-28 Elucidating the role of MPL at the branch point of Erythrocytes andMegakaryocytes lineages.
Akinori Yuzuriha1, Naoshi Sugimoto1,2 , Koji Eto1

(1The Koji Eto Lab, Department of clinical application, Center for iPS Cells
Research and Application, Kyoto University, 2 Department of Hematology andOncology, Graduate school of Medicine, Kyoto University)

P-29 Oligodendrocytes and macrophages contribute stem cell niche for glioblastoma
in the edge of the tumor mass
Takuichiro Hide1, Yoshihiro Komohara 2 , Keishi Makino1, Hideo Nakamura1,
Shigetoshi Yano1, Motohiro Takeya 2 , Jun-ichi Kuratsu1(1Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto
University, 2Department of Cell Pathology, Graduate School of Medical Sciences,
Kumamoto University)

P-30 Molecular characterization of dormant metastatic human breast cancer stem
cells
Yohei Shimono1, Tatsunori Nishimura 2 , Junko Mukohyama1, Taichi Isobe3 ,Toru Mukohara4 , Noriko Gotoh2 , Hironobu Minami4

11

14th Stem Cell Research Symposium

Abstract / Poster(1Division of Molecular and Cellular Biology, Kobe University Graduate School of
Medicine, 2Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa
University, 3Institute for Stem Cell Biology and Regenerative Medicine, Stanford
University, 4Division of Oncology/Hematology, Kobe University Graduate School of
Medicine)Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 20 (Fri)-May 21 (Sat), 2016

P-31 Localization of distinct subsets of nestin-expressing cells in human bonemarrow and their abnormalities in myelodysplastic syndromes
Luan Cao Sy1, Naoshi Obara 2 , Tatsuhiro Sakamoto1, Takayasu Kato2 ,Hidekazu Nishikii2 , Satoshi Ikeda3 , Keiko Suzuki3 , Shigeru Chiba 2(1Hematology, Graduate School of Comprehensive Human Sciences, University ofTsukuba, 2Department of Hematology, Faculty of Medicine, University of Tsukuba,
3
Department of Pathology, Tsuchiura Kyodo General Hospital)

P-32 Heterozygous Dnmt3a mutation induces expansion of hematopoietic stem cellpool in a murine model
Takashi Higo1, Junji Koya1, Yoshiki Sumitomo2,3 , Takako Tsuruta-Kishino1,
Keisuke kataoka1, Tomohiko Sato1, Mineo Kurokawa1(1Department of Hematology & Oncology, Graduate School of Medicine, The
University of Tokyo, 2Department of Hematology & Oncology, Graduate School of
Medicine, The University of Tokyo, 3Oncology Research Laboratories, Kyowa
Hakko Kirin Co., Ltd.)

P-33 Maintenance of stemness of breast cancer cells by FRS2beta, a feedback
inhibitor for HER2-ERK pathway, during mammary tumorigenesis
Natsuko Kimura1, Yukino Machida 2 , Daisuke Iejima1, Arinobu Tojo1,
Nobuaki Yoshida 3 , Ko-ichi Akashi4 , Hideyuki Saya5, Issay Kitabayashi2 ,Noriko Gotoh1,6(1Division of Molecular Therapy, Institute of Medical Science, University of Tokyo,
2
Division of Hematological Malignancy, National Cancer Center ResearchInstitute, 3Division of Developmental Genetics, Institute of Medical Science,
University of Tokyo, 4Department of Medicine and Biosystemic Science, Kyusyu
University, 5Div. of Gene Regulation, Inst., Advanced Med. Res., Grad. Sch. of Med.,
Keio Univ.,, 6Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa
University)

P-34 CD74-NRG1, an oncogenic fusion gene product, leads to ErbB-NF- κ B-IGF2
autocrine/paracrine circuit and confers cancer stem cell properties
Takahiko Murayama1,2 , Takashi Nakaoku3 , Masato Enari4 ,Tatsunori Nishimura 2 , Kana Tominaga1, Asuka Nakata 2 , Arinobu Tojo1,
Sumio Sugano5, Takashi Kohno3 , Noriko Gotoh1,2(1Division of Molecular Therapy, Institute of Medical Science, University of Tokyo,
2
Division of Cancer Cell Biology, Cancer Research Institute of Kanazawa
University, Kanazawa University, 3Division of Genome Biology, National Cancer
Center Research Institute, 4Division of Refractory Cancer Research, National
Cancer Center Research Institute, 5Laboratory of Functional Genomics,
Department of Medical Genome Sciences, Graduate School of Frontier Sciences,
University of Tokyo)

P-35 C6 glioma stem cell-derived extracellular vesicles promote the development ofmacrophages
Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga

(Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU))

P-36 Development of mouse brain tumor models using in vivo electroporation andpiggyBac system
Nobuyuki Onishi, Hideyuki Saya(Division of Gene Regulation, Institute for Advanced Medical Research, Keio
University School of Medicine)P-37 The role of mTOR complex 1 in hematopoiesis and leukemogenesis
Hui Peng, Atsuo Kasada, Masaya Ueno, Takayuki Hoshii, Atsushi Hirao(Cancer Research Institute of Kanazawa University)

14th Stem Cell Research Symposium

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May 20 (Fri)-May 21 (Sat), 2016

(1Division of Molecular Therapy, Institute of Medical Science, University of Tokyo,
2
Department of Breast and Endocrine Surgery, Graduate School of Medicine,
University of Tokyo, 3Division of Molecular Therapy, Institute of Medical Science,
University of Tokyo, 4Department of Breast and Endocrine Surgery, Graduate
School of Medicine, University of Tokyo, 5Department of Breast and Endocrine
Surgery, Showa General Hospital, 6Department of Gastrointestinal Surgery,
Graduate School of Medicine, University of Tokyo, 7Division of Cancer Cell Biology,
Cancer Research Institute, Kanazawa University)

P-39 CGRP-CRLR signaling is important for leukemogenesis in AML with high
EVI1 expression
Akira Suekane, Yusuke Saito, Shingo Nakahata, Kazuhiro Morishita(Div of Tumor and Cellular Biochemistry, Dept of Medical Sci. Fac. of Med. Univof Miyazaki)(Department of Stem Cell Regulation, Medical Research Institute, Tokyo Medical
and Dental University (TMDU))(1Division of Molecular Therapy, Institute of Medical Science, University of Tokyo,
2
JSPS Research Fellow, 3Department of Breast & Endocrine Surgery, Graduate
School of Medicine, University of Tokyo, 4Division of Cancer Cell Biology, Cancer
Research Institute, Kanazawa University)

P-42 Resistance of glioma stem cells to 5-aminolevulinic acid (ALA)-based detection
due to enhanced metabolic conversion of protoporphyrin IX
Wenqian Wang1, Kouichi Tabu1, Yuichiro Hagiya 2 , Shun-ichiro Ogura 2 ,Tetsuya Taga1(1Dept. of Stem Cell Regulation, Tokyo Med. & Dent. Univ, 2Grad. Sch. of Biosci.
and Biotech., Tokyo Inst. of Technology)

P-43 GPR56 is one of important LSC surface markers associated with poor outcome
AML
Yusuke Saito, Kazuko Kaneda, Akira Suekane, Shingo Nakahata,
Kazuhiro Morishita(Div of Tumor and Cellular Biochemistry, Dept of Medical Sci. Fac. of Med. Univof Miyazaki)

P-44 Functional and comprehensive investigation of microRNA targeting Notch
receptors
Ryo Nasu1, Kazuki Okuyama1, Daisuke Ohgiya 2 , Katsuto Hozumi3 ,Akihiko Murata4 , Kiyoshi Ando2 , Ai Kotani1

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14th Stem Cell Research Symposium

Abstract / Poster(1Division of Hematological Malignancy, Institute of Medical Science, Tokai
University, 2Department of Hematology and Oncology, Tokai University School of
Medicine, 3Department of Immunology, Tokai University School of Medicine,
4
Department of Immunology, Tottori University Faculty of Medicine)

Abstract / Special Abstract / Oral (1st Day) Abstract / Oral (2nd Day)

P-41 MICAL3 regulates tumor initiating activity in human breast cancer stem cells.
Kana Tominaga1,2 , Kei-ichiro Tada 3 , Arinobu Tojo1, Noriko Gotoh1,4Program / Poster

P-40 Adaptive response of rat C6 glioma stem cells to iron deprivation by which thedevelopment of tumor infiltrating macrophages is induced
Kouichi Tabu, Yasuhiro Kokubu, Nozomi Muramatsu, Shunki Nomoto,Wenqian Wang, Tetsuya Taga

Program / 1st Day Program / 2nd Day

P-38 GDF15 promotes tumor sphere formation in breast cancer
Asako Sasahara1,2 , Kana Tominaga 3 , Keiichiro Tada4 , Hajime Kanauchi5,
Yasuyuki Seto6 , Arinobu Tojo3 , Noriko Gotoh1,7

P-45 NOTCH signaling pathway in bone marrow nestin-expressing cells controls
balance of erythropoiesis between bone marrow and spleen
Tatsuhiro Sakamoto1, Naoshi Obara 2 , Ryosuke Fujimura3 , Takayasu Kato2 ,Luan Cao Sy1, Hidekazu Nishikii4,5, Mamiko Sakata-Yanagimoto2 ,Satoru Takahashi6 , Shigeru Chiba 2(1Department of Hematology, Graduate School of Comprehensive Human Sciences,
University of Tsukuba, 2Department of Hematology, Faculty of Medicine,
University of Tsukuba, 3School of medical science, University of Tsukuba,
4
Department of Hematology, Faculty of Medicine, University of Tsukuba,
5
Department of Medicine, Division of Blood and Marrow Transplantation, Stanford
University, 6Department of Anatomy and Embryology, Faculty of Medicine,
University of Tsukuba)

P-46 Nanog alone induces germ cells in primed epiblast in vitro by activation ofenhancers
Kazuhiro Murakami1, Ufuk Gnesdogan2 , Azim Surani2(1Div. of Epithelial Stem Cell Biology, Cancer Research Inst., Kanazawa Univ., 2The
Gurdon Inst., Univ. of Cambridge)

Abstract / Poster

Abstract / Oral (2nd Day) Abstract / Oral (1st Day) Abstract / Special

Program / Poster

Program / 2nd Day Program / 1st Day

May 20 (Fri)-May 21 (Sat), 2016

14th Stem Cell Research Symposium

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