Symposia
Symposium 1 (Room A) 9:00 〜 11:30, December 12, (Tue.)
S1. Allergy: state-of-the-art
Chairpersons: Hiroshi Nakajima (Chiba University)
Susumu Nakae (The University of Tokyo)
S1-1

9:00 〜 9:30

Bart Lambrecht (VIB Center for Inflammation Research)
Dendritic cell epithelial cell interactions at the origin of asthma

S1-2

9:30 〜 10:00

Kazuyo Moro (Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical
Sciences (IMS), Yokohama, Japan / Division of Immunobiology, Department of Medical Life
Science, Graduate School of Medical Life Science, Yokohama City University, Yokohama,Japan)
Pathway of development and maturation of ILC2 from the fetal liver to peripheral tissues

S1-3

10:00 〜 10:30

Yamashita Masakatsu (Graduate School of Medicine, Ehime University, Ehime, Japan)
The critical role of Bach2 in regulating type 2 inflammation

S1-4

10:30 〜 11:00

Hajime Karasuyama (Department of Immune Regulation, Graduate School of Medical andDental Sciences, Tokyo Medical and Dental University, Tokyo, Japan)
Emerging roles of basophils in allergic inflammation and immune regulation

S1-5

11:00 〜 11:30

Hannah J Gould (King's College London, London, UK)
The Role of Mucosal B cells in IgE Memory

Symposium 2 (Room B) 9:00 〜 11:30, December 12, (Tue.)S2. Innate Immune Sensors and Diseases
Chairpersons: Kensuke Miyake (The University of Tokyo)
Takeshi Tsubata (Tokyo Medical and Dental University)
S2-1

9:00 〜 9:35

Osamu Nureki (Graduate School of Science, The University of Tokyo, Tokyo, Japan)
Molecular mechanism of CRISPR-Cas and structure-based development of genome editing
tool towards medical applications

S2-2

9:35 〜 10:10

Nobuhiko kayagaki (Genentech)
The Noncanonical Inflammasome

S2-3

10:10 〜 10:35

Takuma Shibata (The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. /CREST, Japan Science and Technology agency, Saitama, Japan.)
Guanosine sensing by TLR7 and its implication in inflammatory disease

S2-4

10:35 〜 11:05

Takeshi Tsubata (Medical Research Institute, Tokyo Medical and Dental University, Tokyo,Japan)
CD72 recognizes RNA-related self-antigens and prevents autoimmunity

S2-5

11:05 〜 11:30

Keisuke Horikawa (The John Curtin School of Medical Research, The Australian National
University, Canberra, Australia)
Oncogenic MYD88 mutations, the dark side of innate immune signalling(3)Symposium 3 (Room C) 9:00 〜 11:30, December 12, (Tue.)S3. Tissue-specific immune diseases
Chairpersons: Mamoru Watanabe (Tokyo Medical and Dental University)
Sachiko Miyake (Juntendo University)
S3-1

9:00 〜 9:30

Michael B Brenner (Harvard Medical School, Boston, Massachusetts, USA)New Insights into Rheumatoid Arthritis Autoimmunity and Tissue Pathology

S3-2

9:30 〜 10:00

Takashi Yamamura (National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan)
Effects of IL-6 signaling blockade for the central nervous system autoimmune disease,neuromyelitis optica (NMO)

S3-3

10:00 〜 10:30

Kenji Kabashima (Department of Dermatology, Kyoto University Graduate School ofMedicine, Kyoto, Japan)
Cutaneous immune responses to external stimuli in terms of inducible skin-associatedlymphoid tissue (iSALT)

S3-4

10:30 〜 11:00

Kiyoshi Takeda (Graduate School of Medicine, Osaka University, Osaka, Japan / IFReC,
Osaka University, Osaka, Japan)
Involvement of microbiota in immune diseases

S3-5

11:00 〜 11:30

Ken Cadwell (Skirball Institute, New York University School of Medicine, New York, USA)
Transkingdom interactions in the gut
JSPS: Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented
Researchers

Symposium 4 (Room D) 9:00 〜 11:30, December 12, (Tue.)S4. Pathogen infection and host responses
Chairpersons: Mari Kannagi (Tokyo Medical and Dental University)
Toshihiko Suzuki (Tokyo Medical and Dental University)
S4-1

9:00 〜 9:30

Akinori Takaoka (Institute for Genetic Medicine, Hokkaido University,)
Host sensing mechanism for IFN-mediated antiviral defense

S4-2

9:30 〜 10:00

Marcelo J. Kuroda (Tulane National Primate Research Center, Tulane University School ofMedicine, USA)
Distinct roles for short- and long-lived macrophages in the pathogenesis of AIDS: Lessons
from the SIV/rhesus macaque model

S4-3

10:00 〜 10:30

Atsuhiko Hasegawa (Department of Immunotherapeutics, Tokyo Medical and DentalUniversity, Tokyo, Japan)
Potential prophylactic vaccine to protect against ATL development via induction of functional
HTLV-1-specific CD8+ T cell responses

S4-4

10:30 〜 11:00

Edward A Miao (University of North Carolina at Chapel Hill, Chapel Hill, USA)
Caspase-7 drives bacterial clearance after perforin-mediated cytotoxicity

S4-5

11:00 〜 11:30

Yuumi Nakamura (Department of Dermatology, Chiba University Graduate School ofMedicine, Chiba, Japan)
Understanding the link between Staphylococcus aureus colonization and skin disease(4)

Symposium 5 (Room A) 8:30 〜 11:00, December 13, (Wed.)
S5. Mucosal Immunity and the Microbiota:
US-Japan Immunology Program Co-organized Session
Chairpersons: Kenya Honda (Keio University)
Satoshi Uematsu (Chiba University)
S5-1

8:30 〜 9:00

Hiroshi Ohno (RIKEN Center for Integrative Mdical Sciences, Kanagawa, Japan / Intestinal
Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kanagawa,Japan)
Characteristics of M cells and follicle-associated epitheliumS5-2

9:00 〜 9:30

Masayuki Amagai (Department of Dermatology, Keio University School of Medicine, Tokyo,
Japan / Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences,Yokohama, Japan)
Stratum corneum as niche for skin microbiome

S5-3

9:30 〜 10:05

Jeremiah J Faith (Icahn School of Medicine at Mount Sinai, New York, USA)The influence of interpersonal variation in human microbiome composition on immune tone
and disease susceptibility

S5-4

10:05 〜 10:40

Noah W Palm (Yale University, New Haven, CT, USA)
Functional Classification of the Human Intestinal MicrobiotaS5-5

10:40 〜 11:00

Yun-Gi Kim (Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan)
Neonatal Acquisition of Clostridia Species Controls Colonization Resistance Against Bacterial
Pathogens

Symposium 6 (Room B) 8:30 〜 11:00, December 13, (Wed.)
S6. Systemic immune diseases
Chairpersons: Hitoshi Kohsaka (Tokyo Medical and Dental University)
Tomohiro Morio (Tokyo Medical and Dental University)
S6-1

8:30 〜 9:05

Kaan Boztug (Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD))
Rare Disease, Monogenic Immune Dysregulation, and Precision Medicine

S6-2

9:05 〜 9:31

Motoi Yamashita (Department of Pediatrics and Developmental Biology, Tokyo Medical andDental University, Tokyo, Japan / Center for Integrative Medical Sciences, RIKEN, Kanagawa,Japan)
B cell differentiation defect caused by IKZF3 mutation.

S6-3

9:31 〜 9:57

Megumu Saito (Center for iPS cell research and application (CiRA), Kyoto University, Kyoto,Japan)
Modeling primary immunodeficiencies with induced pluripotent stem cells.

S6-4

9:57 〜 10:23

Kazuhiko Yamamoto (Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan)
Functional insights from genetic information of autoimmune diseases

S6-5

10:23 〜 10:58

Maripat Corr (University of California, San Diego, La Jolla, United States)
Paradoxical Modulation Strategies for Systemic Autoimmune Diseases(5)Symposium 7 (Room C) 8:30 〜 11:00, December 13, (Wed.)
S7. Cancer Immunity and Cancer Immunotherapy
Chairpersons: Jerome Galon (INSERM)
Shin-ichiro Fujii (RIKEN)
S7-1

8:30 〜 9:05

Jeffery W Pollard (MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh,
UK. / Department of Developmental and Molecular Biology, Albert Einstein College ofMedicine, New York, New York 10461, USA)
Macrophage-Tumor cell partnership promotes metastasis.

S7-2

9:05 〜 9:30

Shin-ichiro Fujii (Laboratory for Immunotherapy, RIKEN Center for Integrative MedicalSciences (IMS) / Program for Drug Discovery and Medical Technology Platforms, RIKENDMP)
Development of new cellular vaccine systems with synergistic immunopotentiating effects

S7-3

9:30 〜 9:55

Koji Tamada (Yamaguchi University Graduate School of Medicine, Ube, Japan)
Novel approaches of gene-modified T cell therapy for solid tumors

S7-4

9:55 〜 10:25

Hiroshi Shiku (Department of Immuno-Gene Therapy, Mie University Graduate School ofMedicine, Mie, Japan)
Adoptive cell therapy with TCR-gene engineered T cells and Beyond

S7-5

10:25 〜 11:00

Jerome Galon (INSERM UMRS1138, Cordeliers Research Center, Paris, France)
Immunoscore and classification of cancers

Symposium 8 (Room D) 8:30 〜 11:00, December 13, (Wed.)
S8. Immunosystem development
Chairpersons: Ichiro Taniuchi (RIKEN)
Tomokatsu Ikawa (RIKEN)
S8-1

8:30 〜 9:00

Tomokatsu Ikawa (RIKEN Center for Integrative Medical Sciences, Yokohama, Japan)
Transcriptional programs that drive the differentiation of B lymphocytes

S8-2

9:00 〜 9:30

Albert BENDELAC (University of Chicago, Chicago, Illinois, USA)
Shared. transcriptional control of innate and innate-like lymphocytesgammdelta

S8-3

9:30 〜 10:00

Masaki Miyazaki (Department of Immunology, Institute for Frontier Life and MedicalSciences, Kyoto University, Kyoto, Japan)
The E-Id Protein Axis Orchestrates the Cell Lineage Choice of Adaptive versus Innate
Lymphoid Cells

S8-4

10:00 〜 10:30

Thomas Boehm (Max Planck Institute of Immunobiology and Epigenetics, Freiburg,Germany)
Reconstruction of ancient thymopoietic environments

S8-510:30 〜 11:00

Ichiro Taniuchi (RIKEN, Center for Integrative Medical Sciences, Yokohama, JAPAN.)
Roles of Runx Transcription Factors In Immune Cell Development.

(6)Symposium 9 (Room A) 8:30 〜 11:00, December 14, (Thu.)
S9. Immunological tolerance: US-Japan Immunology Program Co-organized Session
Chairpersons: Mitsuru Matsumoto (Tokushima University)
Shohei Hori (The University of Tokyo)
S9-1

8:30 〜 8:55

Atsushi Tanaka (Immunology Frontier Research Center, Osaka University, Osaka, Japan)
Treg-specific control of TCR signaling molecules

S9-2

8:55 〜 9:30

Peter Savage (University of Chicago, Chicago, USA)
Role of antigen in regulatory T cell development and homeostasis

S9-3

9:30 〜 9:55

Hayato Takahashi (Department of Dermatology, Keio University School of Medicine)
Peripheral tolerance against desmoglein 3, a pemphigus autoantigen

S9-4

9:55 〜 10:25

Mitsuru Matsumoto (Institute for Enzyme Research, Tokushima University)
Tissue-specific autoimmune response controlled by AireS9-5

10:25 〜 11:00

Kathryn M Haskins (University of Colorado School of Medicine, Aurora CO, USA)
Hybrid Insulin Peptides - Neo-Antigens in Type 1 Diabetes

Symposium 10 (Room B) 8:30 〜 11:00, December 14, (Thu.)
S10. Activating and Inhibitory immunoreceptors in innate immunity:
US-Japan Immunology Program Co-organized Session
Chairpersons: Akira Shibuya (University of Tsukuba)
Sho Yamasaki (Kyushu University)
S10-1

8:30 〜 9:00

Hisashi Arase (Laboratory of Immunochemistry, WPI Immunology Frontier Research Center,
Osaka University, Japan / Department of Immunochemistry, Research Institute for Microbial
Diseases, Osaka University, Japan)
Paired receptors in host-pathogen interaction

S10-2

9:00 〜 9:30

Chigusa Nakahashi-Oda (Department of immunology, Faculty of Medicine, University ofTsukuba, Ibaraki, Japan)
Involvement of a new phosphatidylserine receptor, CD300a, in inflammatory diseases

S10-3

9:30 〜 10:00

Colonna Marco (Department of Pathology and Immunology, Department of Pediatrics,Washington University School of Medicine, St Louis, MO, USA)
Signals controlling conversion of NK cells into ILC1-like cells by

S10-4

10:00 〜 10:30

Sho Yamasaki (Department of Molecular Immunology, Research Institute for Microbial
Diseases, Osaka University, Suita, Japan / Molecular Immunology, Immunology Frontier
Research Center, Osaka University / Molecular Immunology, Medical Institute ofBioregulation, Kyushu University)
Sensing tissue damage through C-type lectin receptors

S10-5

10:30 〜 11:00

David H. Raulet (Immunotherapy and Vaccine Research Initiative, Department of Molecularand Cell Biology, Division of Immunology and Pathogenesis, University of California,Berkeley, Berkeley, CA, 94720, USA / Dragonfly Therapeutics / Innate Pharma / ADURO
Biotech / Ignite Immunotherapy)
Natural Killer cell activation and inhibition: potential for cancer therap(7)Symposium 11 (Room C) 8:30 〜 11:00, December 14, (Thu.)
S11. Dendritic cells and Macrophages
Chairpersons: Toshiaki Ohteki (Tokyo Medical and Dental University)
Yasutaka Okabe (Kyoto University)
S11-1

8:30 〜 9:00

Martin Guilliams (1Laboratory of Myeloid Cell Ontogeny and Functional Specialisation, VIBUGhent Centre for Inflammation Research, Ghent 9052, Belgium 2Department of Biomedical
Molecular Biology, Ghent University, Ghent 9052, Belgium)
The macrophage niche: in search of the tissue-specific mechanisms controlling macrophagedevelopment

S11-2

9:00 〜 9:30

Daniel Mucida (The Rockefeller University, New York USA)
Tissue Adaptation of Intestinal Macrophages

S11-3

9:30 〜 10:00

Yasutaka Okabe (Institute for Frontier Life and Medical Sciences, Kyoto University)
Functional Specialization of Macrophages in Peripheral Tissues

S11-4

10:00 〜 10:30

Shunsuke Kawamura (Medical Research Institute, Tokyo Medical and Dental University,Tokyo, Japan)
Identification of human common monocyte progenitors.

S11-5

10:30 〜 11:00

Tomohiko Tamura (Department of Immunology, Yokohama City University Graduate Schoolof Medicine, Yokohama, Japan)
IRF transcription factors in the development and function of mononuclear phagocytes

Symposium 12 (Room I) 8:30 〜 11:00, December 14, (Thu.)
S12. T/B cell dynamics in humoral immune responses
Chairpersons: Daisuke Kitamura (Tokyo University of Science)Masato Kubo (Tokyo University of Science)
S12-1

8:30 〜 9:00

Hideki Ueno (Icahn School of Medicine at Mount Sinai, New York, USA)
Circulating Tfh1 cells in Influenza vaccination

S12-2

9:00 〜 9:30

Kosuke Miyauchi (Center for Integrative Medical Science, RIKEN Yokohama Institute,Yokohama, Janan)
Virus replication drive mucosal antibody against heterologous influenza viruses

S12-3

9:30 〜 10:00

Gabriel D. Victora (Rockefeller University)
Germinal center selection and affinity maturation require dynamic regulation ofmTORC1
kinaseS12-4

10:00 〜 10:30

Yoshimasa Takahashi (National Institute of Infectious Diseases, Department of Immunology,Tokyo, Japan)
Induction of broadly-protective B cell responses to mutating viruses

S12-5

10:30 〜 11:00

Kyoko Ochiai (Biochemistry, Tohoku University School of Medicine)
Gene regulatory networks of B-to-plasma cell differentiation orchestrated by IRF4 and its
partner transcription factors(8)