A Message From the Dean of Faculty and Graduate
School of Medicine, the University of Tokyo
Faculty of Medicine, the University of Tokyo was established in 1858, and in May of 2008
we celebrated the 150th anniversary of our founding. University Executives, faculty members,
staff, and students came together for an impressive birthday ceremony, and a studentdesigned monument was installed in front of our main building. To mark the occasion, we
also established the Museum of Health and Medicine in 2011.
With its history and traditions in mind, we must move Faculty of Medicine, theUniversity of Tokyo continuously forward. Each year in our Faculty, some 100 to 110 students
begin medical school and about 40 are admitted to School of Integrated Health Sciences(School of Health Sciences and Nursing until 2009). Also, through our highly competitive
PhD-MD program and the Medical Scientist Training Program that we began in 2008, several
outstanding medical students have already taken their first steps on the road to research
careers. In 2010, we started the Clinical Research Training Program for clinicians and students
who are interested in clinical research. Our graduate school has a wide range of programs ofstudy, and we grant from 150 to 200 doctoral degrees each year. Since its establishment in
2007, our new School of Public Health has admitted many exceptional physicians and publichealth researchers. It is also noteworthy that many students who enter our Master's degree
program in the medical sciences after graduating with Bachelor's degrees in fields other than
medicine continue their studies in our doctoral programs.
We expect that medicine will be at the center of the rapidly advancing life sciences in the
21st century. Furthermore, as we face the consequences of having an increasing number of
elderly people in our population, we know that integrated health sciences, preventive
medicine, environmental medicine, and nursing will become increasingly important. We haveinternationally prominent teachers and researchers working in a wide variety of fields, andnumerous endowed departments and social cooperation programs that embody productive
relations between academia and industry.
Through our Programs for Leading Graduate Students, i.e. Graduate Program for Leadersin Life Innovation (GPLLI) and Graduate Program for Social ICT Global Creative Leaders (GCL),
we support financially graduate students and collaborative research with other graduate
schools. Among our international activities, we teach students mainly from Asia andsoutheast Asia but also from other regions, and we are forging new ties with universities in
Europe and North America.
Thus we are involved in a broad and growing spectrum of activities: investigating thehuman body in health and disease; promoting cross-disciplinary integration at the cuttingedge of medical research and education; improving methods of diagnosis, treatment, andacute and long-term care; strengthening preventive medicine; improving hospital management
and medical services delivery; and communicating effectively in the wider social sphere.
In brief, we continue on our missions to provide the best
possible medical care to patients in need today and to train
top-level research scientists who will lay the foundations of
medicine for tomorrow.

Kohei Miyazono
Dean, Faculty and Graduate School of Medicine
The University of Tokyo

HISTORY
1858

May
Nov.

Practitioners, trained in Dutch (European) medicine in Edo (Tokyo), laid out money to establish
the Shutojo (vaccination center) in Kanda Mitamagaike.
Shutojo was destroyed in a fire that had spread from Kanda Aioicho. Shutojo continued its
operations at other sites such as the residence of Ito Genboku.

1859

Sep.

Shutojo was reconstructed at Shitaya Izumibashi Dohri.

1860

Oct.

Shutojo became an official medical institution of the Shogunate Government.

1861

Oct.

Shutojo was renamed as Seiyo Igaku-Sho (Institute of Western Medicine) and offered coursesof Western Medicine in the fields of Education, Autopsy, and Vaccination.

1863

Feb.

Seiyo Igaku-Sho was renamed as Igaku-Sho (Institute of Medicine).

1868

Jul.

Igaku-Sho, affiliated with the Military Hospital which had been moved from Yokohama to Todo
residence in Shitaya, was renamed as Daibyoin (the Great Hospital).

1869

Feb.
Dec.

The Daibyoin was renamed as Igakko-Ken-Byoin (Medical School and Hospital).
Igakko-Ken-Byoin was renamed as Daigaku Toko (University East Building).

1871

Jul.

The Ministry of Education was established and Daigaku-Toko was renamed as Toko (East
Building).

1872

Aug.

A School System was established. Toko was renamed as Daiichi-Daigaku-Ku- Igakko (The First
University District Medical School).

1874

May

Daiichi-Daigaku-Ku-Igakko was renamed as Tokyo-Igakko (Tokyo Medical School).

1876

Nov.

Tokyo-Igakko was moved to Hongo.

1877

Apr.

Tokyo Igakko, affiliated with Tokyo-Kaisei School, was renamed as The University of Tokyo.
Tokyo Medical School was renamed as The University of Tokyo Faculty of Medicine.

1886

Mar.

The University of Tokyo was renamed as Imperial University, and The University of Tokyo
Faculty of Medicine was renamed as the Imperial University Medical College. A Graduate
School was established.

1897

Jun.

The Imperial University was renamed as Tokyo Imperial University.

1917

Aug.

Eiraku Hospital, affiliated with the Ministry of Education Medical Practice License Examination,
moved to Tokyo Imperial University and was renamed as Koishikawa Hospital affiliated with
Tokyo Imperial University Medical College.

1919

Apr.

A faculty system was established renaming Tokyo Imperial University Medical College as theFaculty of Medicine.

1931

Feb.

The first building of the Faculty of Medicine was constructed.

1936

Jan.
Nov.

The Brain Research Laboratory was built with funds donated by Mr. Hisasaburo Horikoshi.
The second building of the Faculty of Medicine (main building) was constructed.

1947

Oct.

Tokyo Imperial University was renamed as The University of Tokyo.

1950

Apr.

The Institute of Nursing was renamed as The University Nursing School.

1953

Apr.
Jul.

The School of Health Care and Nursing was founded.
The Graduate School was founded, and the Division of Medical Doctor Biological Science wasestablished. The Brain Research Laboratory became the Brain Research Institute of the Facultyof Medicine.

1956

Apr.

The Midwives School was established.

1958

Apr.
May

The Division of Pharmaceutical Sciences became an independent faculty.
The University of Tokyo Faculty of Medicine celebrated its centennial anniversary.

1961

Mar.

The Medical Library was built in commemoration of the centenary.

Apr.

The Institute of Medical Electronics was established.

2

1965

Apr.

The Research Institute of Logopedics and Pediatrics was established. The School of Health Careand Nursing was reorganized as the School of Health Sciences. The Graduate School of The
University of Tokyo was reorganized and the Division of Medical Doctor Biological Science
became the Faculty of Medicine. The Health science Course was established in the Medical
Science Division.

1966

Sep.

The third building of the Faculty of Medicine was constructed.

1971

Apr.

The Laboratory of Animal Experiments was established.

1973

Mar.

The Animal Center for Biomedical Research was constructed.

1983

Jan.

An annex of the third building of the Faculty of Medicine was constructed.

1985

Sep.

The office of International Academic Affairs was established.

1987

Apr.

Specialized courses were introduced to the Graduate School of Medicine.

1992

Apr.

The School of Health Sciences became the School of Health Science and Nursing. The Schoolof International Health was established in the Medical Science Division.
The Radiation Research Institute was established.

Jul.
1995

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, four divisions,Third Basic Medicine, Social Medicine, Third and Fourth Clinical Medicine, were replaced with
Pathology, Immunology and Microbiology, Social Medicine, Reproduction and Development,
and Aging Science and Surgery.

1996

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First Clinical Medicine, Health Science, and International Health, were replaced with Internal
Medicine, Health Science and Nursing, and International Health.

1997

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First and Second Basic Medicine, and Second Clinical Medicine, were replaced with Molecular
Cell Biology, Functional Biology, Radiology and Biomedical Engineering, and Neuroscience.
As a result of the above-mentioned reorganization, three institutes, the Institute of Brain
Research, the Institute of Medical Electronics, and the Institute of Logopedics and Phoniatrics
were made redundant.

		

1999

Apr.

The Master course of Medical Science was established in the Graduate School of Medicine.
This course accepts graduates of all faculties except those from Schools of Medicine, Dentistry,and Veterinary Medicine.

2000

Apr.

The International Research Center for Medical Education was established (A shared facility foreducation and research).

2001

Apr.

The University Branch Hospital was united with the University Hospital.

2002 Mar.
		

Nursing School and Midwives School was closed.
Experimental Building (First Stage) was constructed.

2003

Apr.

The Center for Disease Biology and Integrative Medicine was established.

2004

Apr.

All the National Universities owned by the Japanese Government became National University
Corporations. and the University of Corporation.

2005

Mar.

Experimental Building (Second Stage) was constructed.

2007

Apr.

The School of Public Health was established. This school offers programs for Master of Public
Health.

2008

May.

The University of Tokyo Faculty of Medicine and the University of Tokyo Hospital celebrated
their 150th anniversary.

2010

Apr.

The School of Health Science and Nursing became the School of Integrated Health Sciences.

2011

Jan.

The Museum of Health and Medicine was established.

2013

Apr.

The International Research Center for Medical Education became a facility of the Graduate
School of Medicine.

3As of July 16, 2013

Graduate School of Medicine

Dean Kohei Miyazono

Molecular Cell Biology
P14

Cell Biology andAnatomyBiochemistry andMolecular Biology

Cell Biology
Structural Biology
Structural Cell Biology
Cellular Neurobiology
Molecular Biology
Cellular Signaling
Physiological Chemistry
and Metabolism

Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Yosuke Takei
Masahide Kikkawa
Yoshimitsu Kanai
Shigeo Okabe
Noboru Mizushima
Shigeki Jinno
Hiroyuki Mano
Motonao Nakamura
Hiroki Kurihara

Functional Biology
Physiology
P17
Pharmacology

Integrative Physiology
Cellular and Molecular Physiology
Neurophysiology

Professor
Professor
Professor
Associate Professor
Cellular and Molecular Pharmacology Professor
Systems Pharmacology
Professor

Yasushi Miyashita
Kensaku Mori
Masanobu Kano
Kazuo Kitamura
Masamitsu Iino
Hiroki Ueda

Pathology, Immunology and Microbiology
Pathology

Professor

Pathology and Diagnostic Pathology Associate Professor
Associate Professor

P19
Microbiology
Immunology*Collaborative Department

Masashi Fukayama
Junji Shibahara
Tetsuo Ushiku
Kohei Miyazono

Molecular Pathology
Professor
Surgical Pathology
Microbiology
Professor
Masanori Hatakeyama
Infection Control and Prevention
Professor
Kyoji Moriya
Immunology
Professor
Hiroshi Takayanagi
Clinical Immunology
Tumor Pathology / Infection Pathology / Molecular Oncology

Radiology and Biomedical Engineering
Radiology

Diagnostic Radiology

Biomedical Engineering

Radiotherapy
Nuclear Medicine
System Physiology
Chemical Biology and Molecular Imaging Professor
Biosystem Construction and Control Associate Professor

P21

Professor
Associate Professor
Associate Professor
Associate Professor

Kuni Otomo
Satoshi Kunimatsu
Keiichi Nakagawa
Toshimitsu Momose
Yasuteru Urano
Yusuke Abe

Neuroscience
Basic Neuroscience
P23

4Integrative Medical
Neuroscience

Neuropathology
Neurochemistry
Neurobiology
Developmental Neuroscience
Cognitive Neuroscience
Systems Medical Neuroscience
Child Neuropsychiatry

Professor
Professor
Professor

Takeshi Iwatsubo
Haruhiko Bito
Kenzo Hirose

Associate Professor

Katsuyuki Sakai

Associate Professor

Yukiko Kano

Clinical Neuroscience

Neuropsychiatry

Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Kiyoto Kasai
Hidenori Yamasue
Chihiro Kakiuchi
Shoji Tsuji
Jun Goto
Nobuhito Saito
Kensuke Kawai

Molecular Preventive Medicine

Professor

Kouji Matsushima

Public HealthProfessor

Yasuki Kobayashi

Forensic Medicine
Medical Informatics and Economics

Professor
Professor
Associate Professor

Ken-ichi Yoshida
Kazuhiko Ohe
Kengo Miyo

Cardiovascular Medicine
Vascular Biology
Respiratory Medicine
Gastroenterology
Nephrology
Endocrinology
Nutrition and Metabolism

Professor

Issei Komuro

Professor
Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Takahide Nagase
Kazuhiko Koike
Masaomi Nangaku
Masaomi Nangaku
Takashi Kadowaki
Kohjiro Ueki
Mineo Kurokawa
Kazuhiko Yamamoto
Hiroshi Yotsuyanagi
Akira Akabayashi
Kazuhiro Yoshiuchi
Yutaka Yatomi
Hitoshi Ikeda
Hitoshi Okazaki

Professor
Associate Professor

Tomoyuki Fujii
Kei Kawana

Professor

Yutaka Osuga

Professor
Associate Professor
Associate Professor
Professor
Professor
Professor

Akira Oka
Junko Takita
Sachiko Kitanaka
Tadashi Iwanaka
Tadashi Iwanaka
Masahiro Akishita

Neurology
Neurosurgery

P26

Social Medicine
Occupational,
Environmental andPreventive Medicine
Forensic Medicine, andMedical Informatics andEconomics
Internal Medicine
Medicine I

P28
Medicine II

Clinical Laboratory
Medicine and Pathology*Collaborative Department

Hematology and Oncology
Allergy and Rheumatology
Infectious Diseases
Stress Science and Psychosomatic
Medicine
Clinical Laboratory Medicine
Transfusion Medicine
Molecular Diabetology

Reproductive, Developmental and Aging Sciences
Obstetrics andGynecology
P32
Pediatric Sciences

Aging Sciences*Collaborative Department

Reproductive Endocrinology
Gynecological Oncology
Perinatal Medicine
Molecular Cellular Reproductive
Medicine
Pediatrics

Developmental Pediatrics
Pediatric Surgery
Pediatric Oncology
Geriatrics
Aging Research
Health Policy for Children and Families

5Surgical Sciences
Surgery
P35

Thoracic Surgery
Cardiovascular Surgery

Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor

Jun Nakajima
Minoru Ono
Noboru Motomura
Yasuyuki Seto
Sachiyo Nomura
Norihiro Kokudo
Kiyoshi Hasegawa
Yukio Homma
Haruki Kume
Hiroaki Nishimatsu
Yasuhiko Sugawara

Professor
Associate Professor
Vascular Surgery
Associate Professor
Metabolic Care and Endocrine Surgery Associate Professor
Professor
Dermatology
Associate Professor
Associate Professor
Plastic and Reconstructive Surgery Professor
Oral and Maxillofacial Surgery
Professor
Associate Professor
Associate Professor
Orthopaedic Surgery
Professor
Associate Professor
Associate Professor
Ophthalmology
Professor
Associate Professor
Associate Professor
Otorhinolaryngology and Head &Professor
Neck Surgery
Associate Professor
Associate Professor
Rehabilitation Medicine
Professor
Anesthesiology
Professor
Emergency and Critical Care Medicine Professor
Associate Professor

Toshiaki Watanabe
Joji Kitayama
Tetsuro Miyata
Toshihisa Ogawa
Shinichi Sato
Takafumi Kadono
Makoto Sugaya
Isao Koshima
Tsuyoshi Takato
Takafumi Susami
Yoshiyuki Mori
Sakae Tanaka
Hiroshi Kawaguchi
Katsushi Takeshita
Shiro Amano
Satoshi Kato
Miyuki Nagahara
Tatsuya Yamasoba
Takahiro Asakage
Shinichi Iwasaki
Nobuhiko Haga
Yoshitsugu Yamada
Naoki Yahagi
Yoichi Kitsuta

Gastrointestinal Surgery
Hepatobiliary Pancreatic Surgery
Urology
Artificial Organ and Transplantation
Division
Surgical Oncology

Sensory and Motor
System Medicine

Vital Care Medicine

Health Sciences and Nursing
Health Sciences
P42

Health Sociology
Mental Health

Associate Professor
Professor
Associate Professor
Epidemiology and Preventive Health Professor

Naoki Kondo
Norito Kawakami
Akihito Shimazu
Yasuo Ohashi

Professor
Associate Professor

Hideki Hashimoto
Jung Su Lee

Professor
Associate Professor
Professor
Professor
Professor
Associate Professor

Akira Akabayashi
Yoshiyuki Takimoto
Noriko Yamamoto-Mitani
Noriko Yamamoto-Mitani
Kiyoko Kamibeppu
Satoko Nagata

Professor

Noriko Yamamoto-Mitani

Associate Professor
Professor
Professor
Professor

Megumi Haruna
Norito Kawakami
Hiromi Sanada
Hiromi Sanada

Sciences
Health Education
Health Promotion Sciences
Biostatistics
Biomedical Ethics

Preventive andAdministrative Nursing

Clinical Nursing

6

Advanced Clinical Nursing
Nursing Administration
Family Nursing
Community Health Nursing
Public Health Nursing
Adult Health Nursing
Palliative Care Nursing
Midwifery and Women's Health
Psychiatric Nursing
Gerontological Nursing
Wound Care Management

International Health
P46

International Social
Medicine
International
Biomedical Sciences

Global Health Policy
Community and Global Health
Human Genetics
Developmental Medical Sciences
Human Ecology
Biomedical Chemistry

Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Kenji Shibuya
Hiroshi Nishiura
Masamine Jimba
Katsushi Tokunaga
Akihiko Mabuchi
Masashi Mizuguchi
Teruyuki Tanaka
Chiho Watanabe
Masahiro Umezaki
Kiyoshi Kita
Yoh-ichi Watanabe

School of Public Health
P49

Epidemiology and
Health Sciences

Biostatistics
Professor
Social and Preventive Epidemiology Professor
Health Economics and Epidemiology Research Professor
Health Communication
Professor

Behavioral Health
Sciences

Mental Health

Health Services Sciences

Health Sociology and Health Education
Health and Social Behavior
Health Promotion Sciences
Biomedical Ethics
Health Policy
Healthcare Informatics
Clinical Information Engineering
Forensic Medicine and Medical Law

Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Professor

Center for Disease Biology and Integrative Medicine
P53

Laboratory of Molecular Biomedicine for Pathogenesis
Laboratory of Structural Physiology
Laboratory of Regenerative Medical Engineering
Laboratory of Clinical Biotechnology
Laboratory of Environmental Health Sciences
Laboratory of Animal Resources
Laboratory of Molecular Radiology
Divisions of Research Resources and Support(Section of Animal Research)(Section of Radiation Biology)(Section of Bioinfomatics)

Director Masamitsu Iino
Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Toru Miyazaki
Haruo Kasai
Takashi Ushida
Taichi Ito
Kazunori Kataoka
Kanjiro Miyata
Chiharu Tohyama
Seiichiroh Ohsako
Atsu Aiba
Kazuki Nakao
Kiyoshi Miyagawa

Professor
Professor

Atsu Aiba
Kiyoshi Miyagawa

The International Research Center for Medical Education
P56

Yasuo Ohashi
Satoshi Sasaki
Hideo Yasunaga
Takahiro Kiuchi
Hirono Ishikawa
Norito Kawakami
Akihito Shimazu
Naoki Kondo
Hideki Hashimoto
Jung Su Lee
Akira Akabayashi
Yoshiyuki Takimoto
Yasuki Kobayashi
Kazuhiko Ohe
Kengo Miyo
Hiroshi Oyama
Ken-ichi Yoshida

Director Kazuhiko Yamamoto

Department of Medical Education Studies
Professor
Department of International Cooperation for Medical Education

Kiyoshi Kitamura

Institution
P57

The Office of International Academic Affairs
Medical Library
Medical Scientist Training Program
Museum of Health and Medicine
Office for Research Ethics Support

Head
Head
Head
Head
Director
Deputy Director

Yasuyuki Seto
Tsuyoshi Takato
Masahide Kikkawa
Kazuhiko Ohe
Yutaka Yatomi
Akira Akabayashi

7Endowed Department
Pharmacoepidemiology

Professor
Associate Professor
Department of Bone & Cartilage Regenerative Medicine
Associate Professor
Department of Cartilage & Bone Regeneration (Fujisoft)
Associate Professor
Clinical Molecular Epidemiology (Mitsubishi Tanabe Pharma Corporation) Associate Professor
Immunotherapeutics (Medinet)
Associate Professor
Total Renal Care Medicine
Associate Professor
Integrated Molecular Science on Metabolic Diseases
Associate Professor
Department of Advanced Clinical Science and Therapeutics
Associate Professor
Associate Professor
Ischemic Circulatory Physiology, Kaatsu Training
Associate Professor
Translational Research for Healthcare and Clinical Science
Associate Professor
Department of Joint Disease Research
Associate Professor
Health Management and Policy
Professor
Associate Professor
Computational Diagnostic Radiology and Preventive Medicine Associate Professor
Associate Professor
Associate Professor
Clinical Motor System Medicine
Associate Professor
Healthcare Safety Management (Tokio Marine & Nichido)
Professor
Associate Professor
Molecular Cardiovascular Metabolism
Department of Healthcare Quality Assessment
Associate Professor
Anti-Aging Medicine
Professor
Associate Professor
Clinical Epidemiology and Systems
Clinical Trial Data Management
Associate Professor
Pharmacology and Pharmacokinetics
Associate Professor
Ubiquitous Preventive Medicine
Associate Professor
Science for Joint Reconstruction
Professor
Associate Professor
Therapeutic Strategy for Heart Failure
Professor
Molecular Neuroscience on Neurodegeneration
Associate Professor
Chronic Kidney Disease
Associate Professor
Molecular Structure and Dynamics (JEOL / Zeiss)
Professor
Molecular Vascular Endocrinology
Associate Professor
Department of Medical Genomics
Associate Professor
Continence Medicine
Professor
Department of Molecular Psychiatry
Associate Professor
Department of Life Support Technology (Molten)
Associate Professor
Quality Assessment and Control of Medical Device Sterilization
Associate Professor
Department of Youth Mental Health
Associate Professor
Molecular Medicinal Sciences on Metabolic Regulation
Associate Professor
Department of Advanced Nephrology and Regenerative Medicine Associate Professor
Department of Sensory-recognition and Locomotive-function Associate Professor

Sciences in the Super-aged Society
AXA Chair on Health and Human Security
Department of Advanced Translational Research andMedicine in Management of Pulmonary Hypertension
Department of Immunotherapy Management

8

Kiyoshi Kubota
Satoko Setoguchi
Taku Saito
Kazuto Hoshi
Takanari Gotoda
Kazuhiro Kakimi
Norio Hanafusa
Kazuo Hara
Junichi Suzuki
Hiroshi Akazawa
Toshiaki Nakajima
Hiroyuki Morita
Noriko Yoshimura
Soichi Koike
Ryuichi Yamamoto
Naoto Hayashi
Kansei Uno
Takeharu Yoshikawa
Toru Akune
Yasushi Kodama
Katsuyuki Ando
Hiroaki Miyata
Satoshi Inoue
Daisuke Koide
Takuhiro Yamaguchi
Akihiro Hisaka
Toru Suzuki
Yoshio Takatori
Toru Moro
Koichiro Kinugawa
Atsushi Iwata
Miki Nagase
Nobutaka Hirokawa
Masashi Isshiki
CHOI Young Lim
Yasuhiko Igawa
Kazuya Iwamoto
Taketoshi Mori
Yushi Uetera
Tsuyoshi Araki
Hiroaki Okazaki
Keiichi Hishikawa
Kimihiko Kameyama

Professor
Associate Professor

Manami Inoue
Hideki Takimoto

Associate Professor

Hiroko Kanda

Social Cooperation Program
Department of Ubiquitous Health Informatics
Department of Lipidomics
Functional Regulation of Adipocytes
Advanced Nursing Technology

Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor

Hideo Fujita
Takao Shimizu
Yoshihiro Kita
Hironori Waki
Ryoko Murayama

Associate Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor

Naoto Kubota
Satoshi Nishimura
Masato Eto
Keiji Itaka
Daizo Koinuma
Takashi Moritoyo

Research Unit
Research Unit
Translational Systems Biology and Medicine Initiative
Human Resource Development for Multidisciplianary Medical Teams
Graduate Program for Leaders in Life Innovation
Center for early and exploratory clinical trials on dementia,
intractable neurological disorders and psychiatric diseases

Faculty of Medicine

Dean Kohei Miyazono

School of Medicine

Cell Biology and Anatomy / Biochemistry and Molecular Biology / Physiology /Pharmacology / Pathology / Microbiology / Immunology / Radiology /Biomedical Engineering / Basic Neuroscience / Integrative Medical Neuroscience /Clinical Neuroscience / Occupational, Environmental and Preventive Medicine /Medical Principles and Medical Ethics / Forensic Medicine, and Medical
Informatics and Economics / Medicine I / Medicine II / Clinincal Laboratory
Medicine and Pathology / Obstetrics and Gynecology / Pediatric Science /Aging Science / Sugery / Sensory and Motor System Medicine / Vital Care
Medicine

School of
Integrated Health
Sciences

Family Nursing / Community Health Nursing / Fundamental Nursing /Gerontological Nursing / Midwifery and Women's Health /Adult Health and Nursing / Mental Health and Nursing / Health Sociology /Health Administration / Epidemiology and Biostatistics / Human Ecology /Biochemistry and Nutrition / Maternal and Child Health9University Hospital

Director Takashi Kadowaki

Clinical Division
Department ofInternal Medicine

General Medicine
Cardiovascular Medicine
Respiratory Medicine
Gastroenterology
Nephrology and Endocrinology
Metabolic Diseases
Hematology and Oncology
Allergy and Rheumatology
Infectious Diseases
Neurology
Geriatric Medicine
Psychosomatic Medicine

Department ofSurgery

General Surgery
Stomach and Esophageal Surgery
Colon and Rectal Surgery
Hepatobiliary Pancreatic Surgery
Vascular Surgery
Breast and Endocrine Surgery
Artificial Organ and Transplantation
Surgery
Cardiovascular Surgery
Thoracic Surgery
Neurosurgery
Anesthesiology and Pain Relief Center
Urology and Andrology
Gynecologic Surgery

Department ofsensory andMotor System Medicine

Dermatology and Photolaser Medicine
Ophthalmology and Vision Correction
Orthopaedic Surgery and Spinal
Surgery
Otorhinolaryngology, and Auditory
and Voice Surgery
Rehabilitation Medicine
Plastic, Reconstructive and Aesthetic
Surgery
Oral-Maxillofacial Surgery,
Dentistry and Orthodontics

10

Professor
Professor
Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Associate Professor

Kazuhiko Koike
Issei Komuro
Takahide Nagase
Kazuhiko Koike
Masaomi Nangaku
Takashi Kadowaki
Kojiro Ueki
Mineo Kurokawa
Kazuhiko Yamamoto
Hiroshi Yotsuyanagi
Shoji Tsuji
Jun Goto
Masahiro Akishita
Akira Akabayashi
Kazuhiro Yoshiuchi
Yoshiyuki Takimoto
Norihiro Kokudo
Yasuyuki Seto
Sachiyo Nomura
Toshiaki Watanabe
Joji Kitayama
Norihiro Kokudo
Kiyoshi Hasegawa
Tetsuro Miyata
Toshihisa Ogawa
Norihiro Kokudo
Yasuhiko Sugawara
Minoru Ono
Noboru Motomura
Jun Nakajima
Nobuhito Saito
Kensuke Kawai
Yoshitsugu Yamada
Yukio Homma
Haruki Kume
Hiroaki Nishimatsu
Yutaka Osuga
Kei Kawana
Shinichi Sato
Takafumi Kadono
Makoto Sugaya
Shiro Amano
Satoshi Kato
Miyuki Nagahara
Sakae Tanaka
Hiroshi Kawaguchi
Katsushi Takeshita
Tatsuya Yamasoba
Takahiro Asakage
Shinichi Iwasaki
Nobuhiko Haga
Isao Koshima
Tsuyoshi Takato
Takafumi Susami
Yoshiyuki Mori

Department ofPediatrics, Perinatal and
Women's Medicine

Pediatrics
Pediatric Surgery
Obstetrics and Gynecology

Department of
Neuropsychiatry

Neuropsychiatry

Department ofRadiology

Radiology

Professor
Associate Professor
Professor
Professor
Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor

Akira Oka
Sachiko Kitanaka
Tadashi Iwanaka
Tomoyuki Fujii
Yutaka Osuga
Kiyoto Kasai
Hidenori Yamasue
Chihiro Kakiuchi
Kuni Otomo
Keiichi Nakagawa
Toshimitsu Momose
Akira Kunimatsu

Central Clinical Facilities
Pharmaceutical Department
Clinical Laboratory
Operation Center
Imaging Center
Emergency Services
Department of Blood Transfusion
Perinatal Center
Rehabilitation Service
Department of Medical Engineering
Central Supply Service
Intensive Care Unit
Pathology
Department of Corneal Transplantation
Department of Cell Therapy and Transplantation Medicine
Department of Endoscopy and Endoscopic Surgery
Department of Hemodialysis and Apheresis
Medical Community Network and Discharge Planning
Infection Control and Prevention Service
Department of Planning, Information and Management
University Hospital Medical Information Network Center
Organ Transplantation Service
Labor Safety and Health Management OfficeChild Psychiatry
Tissue Bank
Epidemiology and Preventive Medicine
Cancer Resource Center
Center for Liaison and Public Relations
Department of Chemotherapy
Department of Medical Record Management
Critical Care Center
Department of Palliative Medicine
Children's Medical Center
Department of Disaster Medical Management

Professor
Hiroshi Suzuki
Professor
Yutaka Yatomi
Associate Professor Hitoshi Ikeda
Professor
Hiroshi Yasuhara
Associate Professor Kazuhiko Fukatsu
Professor and Director Kuni Otomo
Associate Professor Masaaki Akabane
Professor
Naoki Yahagi
Associate Professor Yoichi Kitsuta
Professor
Hitoshi Okazaki
Professor
Tomoyuki Fujii
Associate Professor Naoto Takahashi
Professor
Nobuhiko Haga
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Associate Professor
Professor
Professor
Associate Professor

Kazuhiko Fukatsu
Naoki Yahagi
Yoichi Kitsuta
Masashi Fukayama
Junji Shibahara
Takeshi Sasaki
Satoru Yamagami
Mineo Kurokawa
Mitsuhiro Fujishiro
Masaomi Nangaku
Eisei Noiri
Kiyoto Kasai
Kyoji Moriya
Kengo Miyo
Takahiro Kiuchi
Hirono Ishikawa
Norihiro Kokudo
Yasuhiko Sugawara
Shin Onishi
Yukiko Kano
Noboru Motomura
Sumihito Tamura
Tsutomu Yamazaki
Sachiyo Nomura
Toshiaki Watanabe
Norihiro Kokudo
Toshiaki Watanabe
Susumu Nakajima
Keichi Nakagawa
Tadashi Iwanaka
Akira Oka
Hiroyuki Nakao

11

International Medical Center
Department of Clinical Nutrition Therapy

Associate Professor
Professor
Associate Professor

Sumihito Tamura
Yutaka Yatomi
Kazuhiko Fukatsu

Professor
Associate Professor
Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor

Tsutomu Yamazaki
Yoshihiro Arakawa
Tsuyoshi Takato
Tsuyoshi Takato
Tetsuro Miyata
Mineo Kurokawa
Shoji Tsuji
Takeshi Iwatsubo
Yoshihiro Arakawa

Professor
Associate Professor
Associate Professor
Professor
Professor

Nobuhito Saito
Shin Onishi
Shin Onishi
Soichi Koike
Nobuhito Saito

Associate Professor
Professor
Professor

Shin Onishi
Kiyoto Kasai
Yutaka Yatomi

Nursing Department
Administration Office

Clinical Research Division
Clinical Research Support Center
22nd Century Medical and Research Center
Department of Tissue Engineering
Cooperative Unit of Medicine and Engineering Research
Translational Research Center
Center for Genome Medicine
Unit for Early and Exploratory Clinical Development

Organization of Clinical Management Support
Department of Personnel Administration and Human Resource Management
Department of Performance Monitoring and Risk Management
Department of Education and Staff Development
Department of Hospital Planning and Management
Department of Research Support

Organization of Clinical Management
Inpatient Services Administration
Outpatient Services Administration
Central Clinical Services Administration

12

Faculty of Medicine
Graduate School of
Medicine
The University of Tokyo

Graduate School of Medicine

Molecular Cell Biology.............................................. 14
Functional Biology..................................................... 17
Pathology, Immunology and Microbiology.................. 19
Radiology and Biomedical Engineering....................... 21
Neuroscience ..........................................................23
Social Medicine........................................................26
Internal Medicine . ...................................................28
Reproductive, Developmental and Aging Sciences . ....32
Surgical Sciences .....................................................35
Health Sciences and Nursing ....................................42
International Health .................................................46
School of Public Health ............................................49
Center for Disease Biology and Integrative Medicine...53
The International Research Center for
Medical Education............................................. 56
Institution

57

The Office of International Academic Affairs
Medical Library
Medical Scientist Training Program
Museum of Health and Medicine
Office for Research Ethics Support

13

A
G
C
T
Molecular Cell Biology

Cell Biology and Anatomy

http://cb.m.u-tokyo.ac.jp/

Cells transport various kinds of proteins, lipids and mRNAs after synthesis
to their specific destinations such as several types of membranousorganelles, protein complexes and the mRNA complex. Thus, intracellulartransport is fundamental to cellular functions, survival and morphogenesis.
Our laboratory is studying the mechanisms of intracellular transport andcellular morphogenesis, especially focusing on molecular motors, Kinesin
superfamily proteins (KIFs) and microtubule associated proteins (MAPs)
using molecular cell biology, biophysics, structural biology, and molecular
genetics.
Molecular cell biological study of KIFs
Studies of the mechanism for recognition of and binding to cargoes by KIFs
and the regulation of this mechanism● Studies of the mechanisms of differential directional transports and sorting● Studies of the dynamics and mechanism of motility of KIFs using molecularbiophysics and structural biology● Molecular genetics of KIFs
● Studies of KIFs and related diseases● Molecular cell biology and molecular genetics of MAPs●●

Schematic representation of intracellular transport
performed by Kinesin superfamily motor proteins, KIFs.
(Reproduced from the cover of Nature Review of
Molecular Cell Biology 10, 2009)http://structure.m.u-tokyo.ac.jp/

Structural Biology
Kikkawa lab is interested in flagella/cilia, which works
as a propeller as well as a sensor of cells. We are
studying the regulatory mechanism of flagella/cilia
using cryo-electron microscopy, optical microscopy
with high-speed camera, cell biology, and genetics. We
are also developing new technologies to analyze
images taken by the microscopes.

3
2

4
5

1

Our focuses are:● Molecular mechanisms of flagella and axonemal
dyneins● Structures of microtubule-associated proteins● Development of new image analysis methods forcryo-electron microscope and high-speed camera

14

6

9
8

7

鞭毛の断面
「９＋２」

外腕ダイニンと内腕ダイニンをつなぐ「司令塔」

Structural Cell Biology

http://cb.m.u-tokyo.ac.jp/

Our research aims to elucidate the cellular architecture, especially focusing on
the cytoskeleton by combining molecular cell biology, molecular genetics andstructural biology.
Structure of the cytoskeleton and the related proteins
Dynamics of the cytoskeleton and the related proteins● Function of the cytoskeleton and the related proteins●●

The neuronal cytoskeleton（From Nature Milestones 2008）

Cellular Neurobiology
The Laboratory of Cellular Neurobiology is interested in understanding themolecular mechanisms regulating synapse formation and maintenance,
which are essential in proper function of neural circuits in the brain. The
laboratory is using optical imaging of synaptic molecules in live neurons, in
combination with molecular biological approaches to modify neuronal
functions.
Molecular architecture of the postsynaptic density
Molecular mechanisms of activity-dependent synapse remodeling● Regulation of synapse functions by glial cells● Regulation of synapse formation and maintenance in vivo●●

Quantitative fluorescence imaging of cultured
hippocampal neurons (green: postsynaptic protein andcalibrated fluorescent microspheres, red: presynaptic
protein, blue: microtubule-associated protein)

Molecular Biology
Our laboratory has been doing trans-disciplinary
studies on autophagy, an intracellular degradation
system, and trying to understand the mechanisms andbiological and pathophysiological functions ofautophagy.

http://www.cellcycle.m.u-tokyo.ac.jp
Lysosome
Isolation membrane

Degradation
Amino acids
etc.

?
Autophagosome

Molecular mechanism of autophagy (its regulation,
membrane dynamism, selectivity, etc.)● Physiological and pathophysiological roles of
autophagy● Development of new methods for monitoring andmodulating autophagy

Protein synthesis
Energy production
Gluconeogenesis, etc●

Starvation adaptation, preimplantation development,
intracellular quality control, tumor suppression,
prevention of neurodegeration, degradation of invading
bacteria, antigen presentation
－/－

+/+

15

Cellular Signaling

http://mano-lab.umin.jp

Through a combined approach of our original functional screening
system and cancer-genome resequencing, we aim to identify
essential growth drivers in human cancer and to develop effectivemeans to treat this intractable disorder. Our research is conductedin a tight collaboration with Department of Medical Genomics.
Discovery of genetic changes directly responsible for
carcinogenesis● Identification of therapeutic targets in human cancer● Development of novel molecular diagnostics for cancer●

Physiological Chemistry and Metabolism

http://bio.m.u-tokyo.ac.jp/

We are investigating signaling mechanisms underlying cell fate
determination, morphogenesis and organogenesis in embryonicdevelopment.
Molecular mechanisms of neural crest fate determination and craniofacial
morphogenesis● Molecular mechanisms of cardiovascular development● Molecular mechanisms of stress responses in preimplantation
development● Roles of non-coding RNA in embryonic development●

Transformation of the upper jaw into a lower jaw inendothelin-1 knock-in (misexpressing) mouse (upper).
The lower is the wild-type control.

16

Functional Biology

Integrative Physiology

http://www.physiol.m.u-tokyo.ac.jp/
indexe/indexe.html

Our laboratory specializes in the neuroscience research on cognitive
functions in the primate. We investigate interactions among manyneurons in the cerebral cortex, which create human cognitive abilities
such as memory and its cognitive control. These studies have been done
through integrative efforts using electrophysiological, molecularbiological and neuroimaging approaches.
Neural circuits of memory neurons in the temporal cortex
Roles of the top-down signal from the prefrontal cortex● Functional architecture of the prefrontal cortex● Molecular biological basis of declarative memory in the primate● Development of optogenetics and viral gene-delivery methods in the
primate● High-field MRI for humans and monkeys●●

Brain activation in cognitive tasks (left) and gene
expression (BDNF) in cortical neurons

Cellular and Molecular Physiology

http://morilab.m.u-tokyo.ac.jp/eindex.html

We aim at a better understanding of neuronal mechanisms thattranslate sensory information of the external world into motivationaland emotional responses. We are currently analyzing the central
nervous system for olfaction, a sensory modality that has a strong
influence on human emotion. Another major focus is to understandcellular and molecular mechanisms for reorganization of neuronal
circuits and memory consolidation in the central olfactory system.
Functional analysis of the neuronal circuit in the central olfactory
nervous system (olfactory bulb and olfactory cortex)● Neurogenesis and neuron-elimination in the adult brain● Cellular and molecular mechanisms for the reorganization ofneuronal circuits and memory consolidation in the central olfactory
system.
●Neuronal circuits and 'odor maps' in the olfactory nervous system

17Neurophysiology

http://plaza.umin.ac.jp/˜neurophy/

Our laboratory studies the function of the synapse, a key
structure for brain functions, and its changes related topostnatal development, learning, and memory. We monitor
neural activity in real time using various methodologies
including; electrophysiology, molecular biology, and opticalimaging of functional molecules.
Postnatal development of synaptic function and organizationin the cerebellum● Retrograde synaptic modulation mediated by endogenous
cannabinoids● Synaptic integration in intact animals● Synaptic plasticity and motor learning in the cerebellum●

Postnatal development of cerebellar climbing fiber to Purkinje cell synapses

Cellular and Molecular Pharmacology

http://calcium.cmp.m.u-tokyo.ac.jp/index-e.html

We are studying the basic principles of Ca2+ signaling, thefundamental signal transduction mechanism of life. Based onsuch studies, we are searching for new functions of Ca 2+
signaling in the central nervous system, and are aiming atshedding new light on brain functions using innovative
imaging methods.

Glutamate

IP3

10 stimuli (50 Hz)

2 µm

500 msCytoplasm
20%
500 msMembrane

Elucidation of basic principles of Ca2+ signaling● Search for new functions of Ca2+ signaling in the brain● Functional analyses of neurons and glial cells using imaging
methods of signaling molecules

Ca

●

NFAT

NO signal
NO-induced
Ca2+ release[Ca2+]er2+

60 s[Ca2+]mt

SynapseN-cadherin

G PLC
Parallel fiber

IP3
AMPA
receptor

Purkinje cell

Pum2

InjuryCa

CaNO

Neuron-Glia

Metabotropic
glutamate receptor

Neuronal death

Pum2

Ca2+
IP3R2

Reactive
astrogliosis
Neuroprotection

Presynaptic maintenance

BDNF

Outline of our research on Ca2+ signaling

Systems Pharmacology
We are aiming at understanding of how multi-stability
and homeo-dynamics in sleep-wake systems, as amodel system, can be achieved through negative
feedback regulation of membrane potential in neurons,
and neural circuit structures. Also, we are establishinga high-throughput production platform of geneticallyengineered mice to facilitate a quantitative analysis andperturbation at the organismal level, and paving theway for the basic research by associating with humangenome analysis obtained from clinical studies.
Elucidation of the regulatory principle of sleep-wakerhythm● High-throughput production platform of geneticallyengineered mice
● Application of human genome analysis from clinicalstudies to basic research●

18

Organism‐level Systems Biology throughUnderstanding of Sleep‐awake Cycle
Elucidation of the regulatory
principle of sleep‐wake rhythm

High‐throughput platformof genetically engineered mice

Application of clinical studies
to basic research

Advanced Genome &Developmental Engineering

Sleep‐awake cycles in CNS“100% ES mice”“Quantitative” or “Qualitative” Oscillation?

How Sleep‐wake History isRecorded in CNS?

Establishment of F0 Phenotyping
through Non‐invasive Analysis

Verification of the Identified Disease‐related Genes from Human Genome
Analysis by Model Animals

Toward multi‐scale understanding of biological systems, we are planning multi‐scale research
activities based on different backgrounds such as physics, chemistry, informatics, engineering,and medicine, and intercommunicating between foundations and clinics.

Pathology, Immunology and Microbiology

Pathology and Diagnostic Pathology

http://pathol.umin.ac.jp/index_e.htm

Chronic inflammation and neoplasm
●
●
●
●
●

●

Application of molecular pathology to pathological diagnosis●●●

Epstein-Barr virus associated gastric carcinoma
Epigenetics of carcinoma
Carcinoma-stromal interaction
Lung adenocarcinoma and its scar formation
Lung fibrosis and adenocarcinoma
Discovery of molecular target for cancer therapy
Establishment of objective criteria for cancer grading

Streamlining and acceleration of pathological diagnostic
processes

Molecular Pathology

1.0

episomeEBV infection induces
methylation of host DNA

0.5

host genome

Cell line A
0

●

EBV

EBV(+)

We investigate the pathogenesis and pathobiology of disease,especially the neoplastic diseases, by means of morphology.
Our goal is to discover new entities and to clarify unknown
pathogenesis of diseases through the interaction with clinicalmedicine.

00.5

EBV(-)

1.0

Methylation of EBV DNA
Methylation of host DNA

Sequential global methylationof viral and host DNA

EBV-associatedgastric carcinoma

http://beta-lab.umin.ac.jp/index.htm

Our research is focused on the molecular mechanisms ofcarcinogenesis. We study the signaling mechanisms of the
TGF-b family, including TGF-b and bone morphogenetic
proteins (BMPs), and elucidate how they regulate
progression of cancers. We also investigate themechanisms of differentiation of murine embryonic stem
cells (ESCs) into various cells, including vascular andlymphatic endothelial cells. Based on these findings, wewill develop new strategies for the treatment of vascularand lymphatic diseases and cancer.
Molecular mechanisms of growth regulation by TGF- b
Roles of TGF- b in epithelial-to-mesenchymal transition● Effects of TGF- b family cytokines on cancer-initiating
cells● Roles of TGF- b family cytokines in vascular andlymphatic diseases● Differentiation of vascular and lymphatic endothelial
cells and mechanisms of diseases●●

Signaling by TGF-β (left) and TGF-β-mediated EMT of mammry epithelial cells (right)

19

Microbiology

http://www.microbiol.m.u-tokyo.ac.jp/

Our major objective is to elucidate molecular mechanisms
underlying development of gastric carcinoma triggered by
infection with Helicobacter pylori. Based on the results obtained
from these studies, we are also developing new strategies forprevention and treatment of infection/inflammation-associatedcancers, which account for ~ 50% of entire human malignancies.
Structural biological analysis of H. pylori oncoprotein CagA
Intracellular signaling pathways targeted by CagA
● Mouse genetic studies on gastric carcinogenesis● Host genetic factors determining gastric cancer susceptibility● Molecular mechanisms linking inflammation and cancer●●

H. pylori - gastric epithelial cell interaction

Infection Control and Prevention
We are engaged in education of medical staff as wellas in daily clinicalacti vities on the prevention of healthcare-associated infection(HAI). Research activities on the pathogenesis of infection with hepatitis
viruses and HIV, in particular, on the mechanism of hepatocarcinogenesis in
HCV infection are also our mission.
Development of preemptive strategies for the control of healthcare-associatedinfection● Development of new methods in infection control and treatment of viral
hepatitis● Molecular pathogenesis of hepatocellular carcinoma in HCV infection● Pathogenesis of progression of HIV infection● Molecular pathogenesis of the mitochondrial disturbances in viral infections● Molecular pathogenesis of hepatitis B viral infection● Host defences to microorganisms● Molecular analysis of innate immunity in microorganism infection● New detection method and pathogenesis of opportunistic cytomegaloviral
infection● Mechanism of multi-drug resistant microorganisms●

Immunology
We aim to comprehensively understand immune responses byanalyzing molecular mechanisms of the development of
immune cells and the regulation of innate and adaptive immune
systems, and to provide novel strategies for the treatment of
immune diseases. We focus on cytokine signal transduction andregulation of gene transcription, emphasizing thedemonstration of in vivo role using genetically modified mice.
The mechanisms underlying the development of immune cells
The pathogenesis of autoimmune diseases such as
rheumatoid arthritis and multiple sclerosis● Interplay between the immune and bone systems● The regulation of mucosal immune responses●●

20

Infection control team rounds

http://www.immunol.m.u-tokyo.ac.jp/english

Radiology and Biomedical Engineering

Radiology

http://www.ut-radiology.umin.jp/

We have been performing a variety of clinically oriented research programs inbiomedical imaging, voxel-based or ROI-based analysis, information analysis
and radiotherapy, such as computer-assisted diagnosis (CAD), PET-based
diagnosis, and intensity modulated radiotherapy (IMRT).
●

Diagnostic Radiology●●●

Radiation Oncology
●
●
●

●

Multi-row detector (up to 16 rows) helical computed tomography
MR imaging, MR digital subtraction angiography, perfusion imaging, anddiffusion tensor imaging/tractography
Physical engineering aspect of radiotherapy
Stereotactic irradiation by gamma knife and synergy system and IMRTClinical and biological studies for reduction of radiation-induced damage

Nuclear Medicine●●

Functional imaging by radioisotope-labeled tracer technology
Evaluation of blood flow and metabolism by emission tomography (PET and
SPECT)

Chemical Biology and Molecular Imaging

Representative images analyzed with computerassisted technology

http://cbmi.m.u-tokyo.ac.jp/

Our research field is so-called chemical biology. One of our main
research interests is to develop novel small molecule-based photofunctional tools for biological and medical research, including
fluorescence probes for detecting various events in living cells andanimals. Recently, we have succeeded to develop fluorescenceprobes for in vivo tumor detection, and they are now applied to realresected human samples by collaborating with many surgeons.
Establishment of rational design strategies for various photofunctional small molecule-based probes● Development of novel fluorescence probes, photosensitizing
probes and caged compounds, and their application to various
living biological samples● In vivo detection and therapy of tumors in model mice and realhuman samples by using rationally designed novel fluorescenceand photosensitizing probes●

21Biosystem Construction and Control

http://www.bme.gr.jp/bme_E/

Our research fields include medical engineering technologies
represented by the artificial organs. Especially in the research of theartificial heart, the goat whose heart was replaced with the new typeof the total artificial heart survived for more than three months. To
rescue the life of cardiopulmonary arrest patients, the compact
emergency life support system has been developed. Other thanthese, researchs and developments of bio-compatible materials,
sensors, new diagnostic devices and an application of theinformation technology have been performed.
Artificial heart
Emergency life support system● Hybrid technology of biological and artificial materials● New blood pumps● Implantable pressure sensor● Implantable angiogenesis observation probe● Application of the information technology●●

22

Helical flow total artificial heart (HFTAH), hybrid cannula andcompact emergency life support system (ELSS)Neuroscience

Neuropathology
Elucidate the pathomechanism of neuronal degeneration and death in major
neurodegenerative disorders (e.g., Alzheimer disease, Parkinson disease), anddevelop novel strategies for disease-modifying therapies.
Structural and functional analysis of g-secretase
Molecular analysis of the mode of action of g-secretase inhibitors● Mechanism of Ab production, aggregation and clearance● Pathological function of b-amyloid binding proteins (e.g., CLAC)● Mechanism of aggregation and neurotoxicity of a-synuclein● Pathological function of familial Parkinson disease gene LRRK2● Strategies for development and validation of disease modifying therapies for
Alzheimer disease (J-ADNI Clinical Study)●●

Phosphorylated α-synuclein deposited in Lewy
bodies of Parkinson's disease and Lewy body disease

Neurochemistry

http://www.neurochem.m.u-tokyo.ac.jp/
Homepage.html

Our brain is able to recognize and memorize external and internal events asthey occur. A functional neural network further stands out by its capacity to
extract patterns and rules, and to associate them with abstract meaning andaffective valence. What are the local and global spectra of the molecularsignaling events in neurons that underlie such complex information
processing at the systems level? Are these events, in turn, converted into
more profound modifications of the synaptic wiring mechanisms? To addressthese issues, we are currently investigating the chemistry and physiology ofvarious neuronal protein complexes near and at synapses.
Molecular investigation (including identification, characterization, opticalmanipulation and real-time visualization) of signaling molecules involved in
activity-dependent modification of synapse, gene expression and neuralcircuit formation.
● Understanding molecular and circuit mechanisms controlling memory andemotional behaviors, through integration of state-of-the-art in vitro and in vivo
neurobiological techniques in molecular optogenetics/imaging, geneticalcircuit tracing, and quantitative and behavioral experiments in combination
with genetically modified mice and gene transfer using viral vectors.
●

A. Single-synapse imaging (left) and frequencynumber response profile (right) of CaMKIIa andcalcineurin
B. Visualization of migrating neurons (green) andradial glial fibers (red) during corticogenesis
C. Novel object recognition task

23

Neurobiology

http://www.neurobiol.m.u-tokyo.ac.jp/

The goal of our research is to elucidate regulation
mechanisms of various cell functions. Toward this goal,
we have been developing novel technologies including
live cell imaging and RNAi technologies.
Development of novel strategy for generating
fluorescent probes for live cell imaging● We develop a high-throughput screening system forconstructing high performance fluorescent probes forlive cell imaging.
● Study of synapse physiology by glutamate imaging
technique● To clarify the dynamics of exocytosis in excitatory synapses, we have tried to quantitatively analyze released
glutamate at individual synapses by using our original optical glutamate probe.
● Novel technology for construction of genome-wide RNAi library● We are currently constructing a high performance genome-wide RNAi library based on our EPRIL technology.
●

Cognitive Neuroscience

http://square.umin.ac.jp/dcntky/English/Etop.html

We are trying to understand the neural mechanisms of human cognition
using functional MRI, EEG and TMS.
Working memory and cognitive control
Attention, perception and consciousness● Mind-reading and prediction of behavior●●

Child Neuropsychiatry
Main diseases of our current research are autism
spectrum disorders (ASD), ADHD, Tourette syndrome andchildhood Obsessive-compulsive disorder (OCD). Fromthe viewpoint of development of brain and mind, we aretrying to investigate pathogenesis of these diseases byintegrating phenomenological, neuropsychological, brainimaging and genetic studies. We are also applying thisintegrative approach to treatment research for patientswith these diseases.

Blood flow in Frontal area by NIRS

Relationship among ASD, TS and OCD
Tourette syndrome (TS)Tics
Persistent deficit insocial communicationand social interaction

ASD“Just right” perception
Persistency

Stereotypy

Hyperdirect pathway

OC symptoms

Cortex＋Indirectpathway －OCD

Striatum
Caudate & Putamen

Dopaminergic
GABAergic
Glutamatergic

Directpathway

D2(－)
D1(＋)
＋
＋
Behavior phenotype, neuropsychological and genetic－
Globus pallidus SN pars compacta
Brain imaging (MRI&NIRS)
study of Tourette syndrome and childhood OCD
externa● Brain-imaging study of ASD, ADHD and Tourette syndromeby－SN pars reticulata－
Subthalamic
structural-MRI, functional-MRI and near-infrared
Thalamus/Ventral tegmentum
nucleus＋ Globus pallidus interna
spectroscopy
Model of Cortico-striatal-thalamic-cortical pathway in TS● Genomic and epigenomic analysis of ASD● Development of predictor of pharmacotherapy and parent training for ADHD
● Effectiveness study of early intervention for autistic preschoolers and group cognitive behavior therapy for adults with ASD●

24

Neuropsychiatry

http://npsy.umin.jp/index-e.html

Our department mainly investigates schizophrenia and pervasive
developmental disorders not only by biological approaches which
integrate neuroimaging, genetic and animal studies, but also by
psycho-social approaches. We also promote the systematic clinicalresearch training programs and the cooperation with the basic
neuroscience research.
Integrated Neuroimaging studies in Schizophrenia Targeting Earlyintervention and Prevention
http://plaza.umin.ac.jp/arms-ut/● Multimodal neuroimaging studies of pervasive developmental disorders● Clinical trials to establish the medical equipment as a clinical test usefulfor the pharmacological treatment of mental disorders●

Multi-modality neuroimaging in neuropsychiatry using a combination of high-resolution MRI, EEG, MEG, NIRS, and PET

Neurology
Our Department is conducting research programs to elucidate
the pathophysiological mechanisms of neurological diseases
including neurodegenerative diseases, immune-mediateddiseases and neuromuscular diseases, and to establish newtherapeutic approaches for these diseases. We are also
providing excellent training programs to become a boardcertified neurologist.

Neurosurgery

Elucidating molecular basis of neurological diseases anddevelopment of mechanism-based therapy

Molecular basis
gene Adevelopment of mechanismbased therapy
disease modifying therapy

gene Bgene C

neuronal
dysfunction

neurodegeneration．．．

Molecular Genetics (identification of disease genes anddevelopment of therapeutic approaches)● Molecular pathophysiology of neurological diseases (protein
structures and functions)● Immune-mediated diseases (autoantibodies)● Neurophysiology and cognitive neuroscience (magnetic
stimulation, NIRS, MEG, PET, and fMRI)● Neuropathology of neuromuscular diseases (pathological studies
on biopsy and autopsy materials)● Multicenter-based clinical research●

http://square.umin.ac.jp/neurotky/

http://www.h.u-tokyo.ac.jp/neurosurg/

The 21st century has been designated as "The Century
of the Brain". To lead Japanese surgical neuroscience,
we have devoted our activities to the following:
advanced clinical neurosurgery, neuroscience researchand graduate and postgraduate education.
Skull base surgery in managing benign or malignant
skull base tumors and cerebrovascular disorders● Functional neurosurgery including epilepsy surgery● Development of new therapeutic strategies formalignat brain tumors● Cinical study on gamma-knife surgery● Application of brain functional imaging forneurosurgery● Application of VR technology for surgical simulation● Experiment on cerebral ischemia● Development of new stenting device forendovascular surgery●

Pre-operative simulation using 3D-fusion images

25

Social Medicine

Molecular Preventive Medicine
The immune system is maintained by continuous
migration of immune cells between lymphoid organs andperipheral tissues. Immune cells change their function
during this migration and interact with tissue cells at the
periphery. In the context of disease, immune cells induce
functional changes, destruction, and remodeling ofaffected tissues. We aim to clearify how immune cell
migration regulates immune function, which may lead tothe development of novel therapeutic and preventive
strategies toward various diseases.

http://www.prevent.m.u-tokyo.ac.jp/

Basic reserch
GVHD

Clinical application

ImmunologicalmemoryIndividual

Drug development

OrgansCell

Gene
expression
analysis

Molecule

Inflammation
Chemokine

Chemokine
signaling

Regeneration

Cellulartrafficking

Chemokine / Chemokine receptor
Antibody→ Anti inflammatory, Cancer therapy,
immuno-modulatory

Vaccine development→ HIV , SARS-CoV etc.

Contribution to society

Molecular and cellular basis of tissue fibrosis during
chronic inflammation● Pathophysiological regulation of the immune system by chemokines and the implication of this in GVHD, tumor development,
infectious diseases, and autoimmunity● Development of vaccines against cancers and infectious diseases● Gene expression analysis of hematopoietic and other tissue cells by next-generation sequencing●

Public Health

http://publichealth.m.u-tokyo.ac.jp/

Public health is the science and art of preventing disease,prolonging life, and promoting health and quality of life
(QOL) through organized community effort. Through studies
in various fields and laboratories, our department aims toadvance research, support policy development, and promote
education toward these ends.
Efficiency and equity issues of health systems
Health manpower policy● Occupational and environmental health● Evaluation of preventive services● Health services research●●Physician distribution by municipality in Japan

26

Forensic Medicine

http://plaza.umin.ac.jp/˜forensic/

We conduct autopsies and examinations related to unnatural
deaths and therapeutic deaths. We also perform the following
studies.
Development of new animal model of sleep apnea syndrome,
and the elucidation of the pathogenesis of heart failure andpulmonary hypertension● Study on the mechanism underlying sudden cardiac deaths andmyocardial lesions related to myocardial infarction andamphetamine-class drug poisoning● Study on the Takotsubo cardiomyopathy-like pathology inrestrained rats
● Study on the mechanism underlying propagation of brain
contusion● Study on the information disclosure, bereavement service, andresearch use of retained organs in death investigation system● Development of new methods for examinations of drug,
histological and DNA analyses in autopsy cases.
●

Medical Informatics and Economics

Forensic autopsy room

http://www.m.u-tokyo.ac.jp/medinfo/index_e.html

The role of research and education of this department is provided
as the department of the graduate school, and the role of practicalmanagement is conducted as the Department of Planning,
Information and Management in the University of Tokyo Hospital.
All teaching staffs are in charge of both the two roles and thedepartment of health informatics of school of public health. The
research and postgraduate education programs cover basic
medical informatics, advance applications of information
technology for clinical practice, technology assessment andstandardization of healthcare information.
Development and application of clinical ontology
Research for sharing healthcare data among medical institutions
and hospitals, and the application for clinical epidemiology● Extraction of medical knowledge from electronic medical record
database using natural language processing
Development of clinical ontology● Development of knowledge-driven real time alerting system inclinical practice● Evaluation study of hospital management and analysis of medical resource placement●●

27

Internal Medicine

Cardiovascular Medicine

http://plaza.umin.ac.jp/~utok-card/

We are investigating the pathogenesis, pathophysiology, diagnostic tools and novel therapeutic approaches for various
cardiovascular diseases including ischemic heart disease, heart failure, cardiomyopathy, arrhythmias, atherosclerosis andhypertension. To carry out the comprehensive study, we are adopting a wide variety of research modalities, such as molecularbiology, iPS cells, genomic analysis, molecular imaging, cardiac mechanics, endothelial function and hypoxia signaling.
Molecular mechanisms of human heart diseases using iPS cells
Interplay between organs, cells and molecules in chronic inflammation● Transcriptional regulation of various genes involved in cardiovasculardevelopment and pathogenesis● Cardiac hypertrophy and heart failure: analyses of pathogenic mechanisms
and development of novel therapies (gene therapy, etc.)● Roles of hypoxia signaling in cardiovascular diseases● Differentiation of smooth muscle cells (atherosclerosis and restenosis after
vascular interventions)● Endothelial dysfunction in various diseases● Genetic polymorphisms and risk factors in cardiovascular disease● Optimization of individual treatment using the Computer Heart Simulator● Development of new integrated databases for clinical information andresearch● Investigation of disease pathophysiology and development of novel therapies (severe heart failure, cardiac transplantation,
Marfan's syndrome, pulmonary hypertension, congenital heart disease, cardiac rehabilitation, etc.)● Imaging techniques (echocardiography, MRI, CT, SPECT) in cardiovascular diseases●●

Respiratory Medicine

http://kokyuki.umin.jp/

Based on the fact that a number of patients with respiratory diseases including lung cancer and COPD is tremendously
increasing, fruitful results of respiratory research are more and more expected in the 21st century. In this era, we areconducting basic and clinical researches for wide variety of respiratory disorders including lung cancer, asthma and COPD.
Especially, we have been intensively studying the molecular mechanisms underlying the pathogenesis of lung disorders.
Our research goal is to develop novel therapeutic tools to manage these pulmonary diseases.
Clinical studies of lung cancer, COPD, bronchial asthma and pulmonary fibrosis
Epidemiological studies of diffuse panbronchiolitis (DPB) and interstitial lung disease● Molecular mechanisms underlying the pathogenesis of acute lung injury or ARDS
● Molecular mechanisms underlying the pathogenesis of pulmonary fibrosis(as shown in Figure)● Analysis of disease models using genetically-engineered mice
● Effects of air pollutants such as diesel exhausts on airway hyperresponsiveness● Roles of chemokines/cytokines and eicosanoids on airway epithelial cells, smoothmuscle cells and eosinophils.
● Molecular mechanisms of epithelial-mesenchymal transition in lung cancer andinflammatory lung disease● DNA methylation and lung cancer● Establishment of conditional vectors for hairpin siRNA knockdowns● Establishment of CpG island searcher● Search of a biomarker of lung cancer and inflammatory lung disease●●

28

Murine model of pulmonary fibrosis

Gastroenterology

http://gastro.m.u-tokyo.ac.jp/med/home.html

Our Department of Gastroenterology is one of the top institutions in the world in
the treatment of hepatocellular carcinoma by unique ablation(RFA) andgastrointestinal/pancreatobiliary cancer/stone by endoscopic manipulation(ESD&ERCP). The goal of our department is to accurately diagnose and give thebest available treatment to these patients, and to this end, we are performing awide variety of basic as well as clinical research.
Development of better therapeutic strategy for hepatitis B and C
Elucidation of hepatocaricinogenesis mechanism in viral hepatitis● Development of a better therapeutic modality for hepatocellular carcinoma& metastatic liver tumor● Elucidation of gastric injury mechanisms by Helicobacter pylori● Clarification of colon disease, especially right-sided colon carcinogenesis● Development of therapeutic strategy for advanced pancreatobiliary cancer● Development of a better endoscopic therapeutic modality for pancreatobiliary cancer/stone● Development of better diagnostic & therapeutic strategy for chronic pancreatitis● Development of an endoscopic en bloc resection method for early gastric, esophageal and colonic cancer● Elucidation of the mechanisms of metabolism-associated liver diseases● Development of better diagnostic & therapeutic strategy for small intestinal diseases●●

Nephrology / Endocrinology

http://www.todai-jinnai.com/

We are investigating the pathophysiology of renal and endocrine
disorders for the development of innovative diagnostic and therapeutic
tools.
Renal physiology and morphology
Abnormal oxygen metabolism of kidney disease● Analysis of pathophysiology and development of therapy of chronic kidneydisease● Development of biomarkers and therapy of acute kidney injury● Role of nitric oxide and oxidative stress in renal disease and hypertension● Clinical and basic investigation of bone and mineral disorders● Mechanism of action of nuclear hormone receptors● Pathophysiology of hypertension and roles of adrenomedullin● G protein signaling in health and disease● Epigenetics●●

Nutrition and Metabolism
We are investigating to reveal the molecular mechanisms underlying thedevelopment of metabolic diseases (diabetes mellitus, lipid metabolic
disorders, obesity, metabolic syndrome and atherosclerosis) using
interdisciplinary approaches and state-of-the-art technology including
genetically engineered model animals, DNA chip, epigenetics, RNAtechnology, human genetics, clinical epidemiology and bioinfomatics. Our
major goal is to develop mechanism-based fundamental treatment andprevention strategies for the metabolic diseases.
Molecular mechanism of insulin resistance linked to obesity focusing on adipokines
Transcriptional regulation of insulin resistance and obesity by nuclear receptors andcofactors● Molecular mechanism of insulin signal transduction● Molecular mechanism of insulin secretory defect in type 2 diabetes● Genetic susceptibility and risk factors of type 2 diabetes● Development of accurate diagnostic algorithm for type 2 diabetes● Molecular mechanism of adipogenesis and obesity● Transcriptional regulation of lipid metabolism● Molecular mechanism of atherosclerosis● Mouse genetic models of diabetes, lipid metabolism disorder and atherosclerosis●●

29

Hematology and Oncology

http://www.h.u-tokyo.ac.jp/hematology/

We investigate the pathogenesis, diagnostic methods, and novel therapeutics of hematological diseases by thecomprehensive use of research technologies in molecular biology, cellular biology, developmental engineering, andgenomic science. Studies about transcriptional regulation and signal transduction in hematopoiesis and analyses ofregulation of hematopoietic stem cells are promoted.
We also implement basic and clinical studies based on
genomics, regenerative medicine, and transplantation
medicine, which aim at application to therapeuticstrategies.
Mechanisms in the regulation of self renewal anddifferentiation in hematopoietic stem cells● Comprehensive genomic and epigenetic analysis ofhematological malignancies● Elucidation of the molecular mechanisms underlying
the pathogenesis of leukemia● Development and analysis of mouse models of
leukemogenesis● Regenerative medicine and pathogenesis study basedon human iPS cell technology●

Allergy and Rheumatology
Allergy and rheumatic diseases are immune mediateddisorders. We are investigating the fine mechanisms of suchdisorders. One of our final purposes is to establish novel
therapies which control pathological immune disorders but
do not suppress other physiologically important immune
functions. We are combining recent findings in basic
immunology and our own viewpoints base on our clinicalexperience.

thymusperiphery

IL-10

ImmatureT

LAG3Naïve T

Foxp3
Treg
negative

Commensal microbiota

Egr2
Treg

Naïve T

selection
Functional analysis of a novel regulatory T cell subset that
Foxp3
Effector
Treg
T
suppresses autoantibody production● Clonal analyses of T cell receptor (TCR) , in vitro reconstitutionof the TCR function using such information and antigen
Development ofof CD4+CD25-LAG3+
CD4+CD25-LAG3+ regulatory
Development
regulatoryT Tcells
cells
specific immunotherapy● Genomic analyses of rheumatic diseases● Development of molecular targeting immunosuppressive reagents● Mechanism of immunological tolerance to autoantigens and immunoregulation● Intracellular signaling in immune disorders● Airway hypersensitivity and remodeling of bronchial asthma● Involvement of chemokines in allergic diseases and applications to therapeutic strategies●

Infectious Diseases
We are investigating both clinical and basic aspects in infectious diseaes, inparticular, on HIV infection and hepatitis viral infections, the latter of which is
the major cause of liver diseae worldwide. Our research topics cover the wide
areas in microbiology, immunology and pathobilology of infectious diseases,
including HIV and HCV infections.
Clinical studies of HIV infection
Treatment and prevention of viral hepatitis● Molecular pathogenesis of hepatocellular carcinoma in HCV infection● Pathogenesis of extrahepatic manifestations and its control in HCV infection● Pathogenesis of progression of HIV infection● Molecular pathogenesis of hepatocellular carcinoma in HBV infection● Molecular pathogenesis of hepatitis B viral infection● Host defences to microorganisms● Molecular analysis of innate immunity in microorganism infection● Pathogenesis of influenza viral infection● Mechanism of multi-drug resistant microorganisms●●

30

B cellStress Sciences and Psychosomatic Medicine

http://psmut.umin.ac.jp/

The targets of our laboratory include stress-related diseases such as primaryheadaches and lifestyle-related diseases, eating disorders and malignancies.
The goals of our work are to determine the mechanisms of these conditions,to develop objective markers for diagnosis and severity, and to discover new
treatment approaches using ecological momentary assessment (EMA),
biochemical assessment of eating-related molecules, and physiologicalassessment of autonomic nervous function.
We are using ecological momentary assessment (EMA) techniques tocollect and evaluate subjective and objective data including physicalactivity and autonomic nervous function in natural settings in stress-relateddiseases. We are also developing new treatments using these methods.
● Investigation into the pathophysiology, psychopathology andneurobehavioral basis of stress-related diseases by use of ecologicalmomentary assessment methods● Using heart rate and blood pressure variability, we are investigating
autonomic nervous function in eating disorders. This work uses non-linear
analyses such as fractal analysis, as well as linear analysis.
● We have developed an egogram questionnaire, which we refer to as the
TEG.
●

Clinical Laboratory Medicine

http://lab-tky.umin.ac.jp/

The main goal of our research projects, described below, is thedevelopment of new and useful laboratory tests, and elucidation ofpathophysiology of diseases through laboratory tests.
(Patho)physiological roles of lysophospholipid mediators, and its
application to laboratory medicine● Platelet biology● Hepatology● Genetic testing● Bioactive peptides, especially adrenomedullin● Oxidative stress and organ damage● Cell surface analysis and quantification of cell surface antigens
usingflow cytometry● Analysis of the ventricle functions using ultrasound● Relationship between the respiratory function and various
pathophysiological conditions● Magnetoencephalographic (MEG) study on neural mechanisms foraudiovisual integration●

Transfusion Medicine

Flow cytometer and analysis patterns

http://square.umin.ac.jp/traf-tky/

The Department of Transfusion Medicine aims the achievement ofsafe and appropriate transfusion practice in the hospital, and forthis purpose, controls, tests and supplies all blood products fortransfusion.
The research fields include:
Detection of red cells/ leukocytes/platelets antigens/antibodies
Development of novel methods for the evaluation of platelet
function● Development of new anti-angiogenic strategies for thetreatment of solid tumors● Use of hematopoietic stem cells in regenerative medicine● Investigation on the pathophysiology of the immunologicaladverse effects of transfusion● Development of new anti-thrombotic materials for clinical use●●

31

Reproductive, Developmental andAging Sciences

Reproductive Endocrinology

http://square.umin.ac.jp/tkyobgyn/

We manage women's reproductive health comprehensively throughout
their respective life stages (adolescence, reproductive ages, menopause,and post-menopause). We also aim to develop advanced reproductive
techniques, which could be practiced with higher success rates andimproved safety, based on experimental and clinical research.
Establishment of effective and low-risk treatment for infertility
Development of assisted reproductive technology● Understanding of interaction between the endometrium and embryo
during the implantation period● Study of pathophysiology of endometriosis● Understanding of local regulation of folliculogenesis● Technical development of advanced endoscopic / minimally invasive
surgery● Development of hormone replacement therapy for perimenopausal /postmenopausal women● Health care for women in perimenopausal / postmenopausal status● Development of oncofertility●●

Gynecologic Oncology

ICSI (intracytoplasmic sperm injection)

http://square.umin.ac.jp/tkyobgyn/

Our basic research in cervical cancer focuses on carcinogenesis and roles of
HPV (Human Papilloma Virus) infection, as well as development oftherapeutic vaccines. In endometrial and ovarian cancers, we haveidentified novel cancer-related genes and their functions, and are exploringnovel molecular-targeted therapies using oncogenomic analyses. Clinically,
we are investigating intensive surgical management, as well as lessinvasive (fertility-sparing) surgery in gynecologic malignancies.
Intensive surgery for advanced or recurrent tumors and less invasive(laparoscopic) surgery for selected patients● Trachelectomy for early staged cervical cancer patients● HPV genotyping and clinical trials of therapeutic vaccines for cervicalintraepithelial noeplasias● Identification of molecular-targeted therapies on basis of genomewide
analyses● Development of novel therapeutics using drug delivery system●

Expression of tumor suppressor scribble in malignant cells

32Perinatal Medicine

http://www.iiosan.umin.jp/

The researches are on going for development of precise prenatal
diagnosis on the fetal status using ultrasonography. We are also
focusing on the immunological aspects and inflammation in pathophysiology of pregnancy. Our goal is to develop the therapy andprevention methods for habitual abortion, pregnancy induced
hypertension, preterm labor, and cerebral palsy.
Early diagnosis of abnormal fetuses using three dimensional
ultrasonography● Management of habitual abortion● Management of complicated pregnancy● Management of preterm labor● Prevention of cerebral palsy of the newborn●

Three dimensional ultrasonography of fetus

Molecular and Cellular Reproductive Medicine
We investigate the molecular mechanisms of reproductive functions
using the knowledge and techniques of molecular and cellularbiology and genetics.
Our studies are focusing on the pathophysiological mechanism of sex
steroid hormones to elucidate how these hormones effect on
reproductive phenomena including embryogenesis, spermatogenesis
and fetal development, and on the prenatal genetic diagnosis.
Effect of sex steroid hormones on reproductive medicine
Molecular mechanisms of embryogenesis● Analysis of implantation mechanism● Analysis of intrauterine fetal development● Prenatal diagnosis using molecular genetics●●

Molecular mechanisms of sex steroids

Pediatrics / Developmental Pediatrics

http://square.umin.ac.jp/ped/

We are studying all aspects concerning the health of infants, children
and adolescents. We have achieved very important contributions toclarify the molecular pathogenesis of pediatric disorders.
Molecular diagnosis and analysis and collaborative treatment of
intractable renal glomerular and tubular diseases● Molecular diagnosis and analyses of hematological malignancies andsolid tumors● Molecular analysis and diagnosis and collaborative treatment of
endocrine/metabolic diseases and diabetes● Diagnosis, molecular analysis and collaborative treatment ofcongenital heart diseases● Investigation of biotin and gut hormones in neonates● Comprehensive analysis of biomarkers in neonatal diseases● Cytokine expression and immunological SNP in neonatal diseases● Neurocognitive effects of intrauterine infection and environmental toxins● Diagnosis and comprehensive treatment of neuromuscular disorders● Molecular diagnosis and treatment of mitochondrial disorders● Early intervention of developmental disorders● Molecular analysis and collaborative treatment of congenital immunodeficiency and allergic diseases●

33

Pediatric Surgery
Pediatric surgical diseases have great variety. In our department allkinds of pediatric surgical conditions are treated, and in these fetal
and neonatal surgical care is our main interest. We also treat many
pediatric patients using minimally invasive surgeries such as
laparoscopy and thoracoscopy.
The development and differentiation of the fetal lung
Fetal diagnosis of congenital malformations● Fetal surgery and treatment● Pediatric minimally invasive surgery● Pediatric robotic surgery● Probiotics and prebiotics applied to padiatric surgical patients● Biliary atresia and biliary dilatation: their treatment and long-term
prognosis● The treatment by regenerative medicine of air way malacia and stenosis● Development of pediatric surgical models●●

EXIT(ex utero intrapartum treatment):Tracheostomy on a fetus
with laryngeal atresia

Pediatric Oncology
Solid tumors in children are dealt with in our department.
Appropriate care strategies combining surgical treatment andchemotherapy are decided and carried out on various malignant
tumors after extremely close discussion with pediatric oncologists.
Genetic analysis and investigations for prognostic factors inneuroblastoma● Tumorigenesis in Wilms tumors● Analysis of cellular biology in Wilms tumors● Treatment of rhabdomyosarcoma● Genetic mutation in hepatoblastoma●

Microscopic and ultramicroscopic features of Wilms tumor cell line

Geriatrics

http://www.h.u-tokyo.ac.jp/patient/depts/rounenbyou/index.html

Our department is the first established department of GeriatricMedicine in Japan. It is our goal to treat all the geriatric diseases, suchas atherosclerosis, hyperlipidemia, osteoporosis, senile dementia,
diabetes, COPD, and aspiration pneumonia, and to improve the qualityof life of elderly patients.
Vascular endothelial function and atherosclerosis
Studies of molecular mechanisms in vascular calcification● Antioxidants inhibit vascular smooth muscle cell proliferation andinduce apoptosis● Vascular gene therapy using adenoviral mediated gene transfer of
estrogen receptors● New guidelines for hormone replacement therapy in females in Japan● Novel gene responsible for breast cancer● Novel gene responsible for osteoporosis● Molecular cloning of novel Ring finger protein● Studies of pathophysiology and novel treatment for Alzheimer's disease● Pathophysiological studies on bronchial asthma using gene-targeted mice
● The antimicrobial peptide, defensin● The molecular mechanisms of vascular injury in sleep apnea syndrome●●34Surgical Sciences

Thoracic Surgery

http://ctstokyo.umin.ne.jp/

We specialize in surgical treatment for malignant neoplasms of the chest,
such as primary lung cancer, pulmonary metastases, and mediastinal
tumors. Patients with these diseases have been increasing recently in ourcountry. We actively perform minimally invasive surgery throughthoracoscopy for patients with comorbidities. We also perform extended
surgery with extracorporeal circulation in collaboration with cardiac
surgeons. In 2012 we performed chest surgery for approximately 300
patients in our institute. We also study on nonsurgical treatment forpatients with postoperative recurrence of lung cancer or refractory
malignant neoplasms, doing new clinical trials of immunotherapy. In
response to increasing number of brain-death donor in our country, we
are now establishing a lung transplantation program in our institute.
Minimally invasive surgery for chest diseases
Genetic studies on primary lung cancer● Clinical or biological studies on thymic neoplasms● Immunotherapy for lung neoplasms● Basic studies on lung or tracheal transplantation●●

Cardiovascular Surgery

Figure: A case of lung cancer with interstitial pneumonia.
(left upper) High-resolution Computed Tomography(left lower) Axial section of 18F-FDG-PET(right upper) Frontal section of 18F-FDG-PET(right lower)resected specimen

http://ctstokyo.umin.ne.jp/

We are leading in Japan by annual surgery case volume of 400.
New knowledge and techniques are actively applied clinically.
Many clinical research projects are going on along with routine
clinical activities. Our laboratories have been also carrying out alarge variety of basic research.
●

Clinical research
●
●
●
●

●

Brain and spinal cord protection in thoracic aortic surgery
Minimally invasive cardiac
Valve or vascular tissue allograft transplantation
Ventricular assist device for end-stage heart failure

Basic and experimental research●●

Development of myocardial regeneration therapy
Analysis of resistance to infection of tissue allograft
MRI diffusion-weighed images of brain by various brain perfusion techniques

35

Gastrointestinal Surgery

http://todai3ge.umin.jp/

Our goal is to cure the cancer patients by much better surgery. The
development of better surgical methods has the highest priority. Better
surgery means radicality of the cancer, minimal invasiveness, and good QOL
after surgery. Recently, non-transthoracic radical esophagectomy withextended lymphadenectomy (NOVEL) has been applied, which shows lesspulmonary complications and good respiratory functions after surgery(Figure).
●For much better surgery●●●

For radicality of advanced cancer treatment
●

●
●

●

NOVEL (non-transthoracic esophageal cancer surgery)NEWS (Non-exposed Endoscopic Wall-inversion Surgery for gastric tumor)
Phase II: S-1, CDDP, Herceptin combined chemotherapy for HER2positive advanced gastric cancer
Chemo-Immunotherapy(DCF+gdT) for advanced esophageal cancer
Adjuvant vaccination for Stage IIA esophageal cancer patients after
surgery

Carcinogenesis, progression, metastasis, and prevention●●●●

Inflammation and gastrointestinal carcinogenesis
Are cancer cells derived from bone marrow?
Early detection of cancer by new biomarkers
Carcinogenic analysis with reflux esophagitis modelHepatobiliary Pancreatic Surgery
We constantly perfom nearly 200 hepatectomies every year on patients with
hepatobiliary malignancies including hepatocellular carcinoma andmetastatic liver tumors. The surgical results can be classified as amongst thehighest ranking in the world. In order to improve the surgical outcome forhepato-biliary-pancreatic malignancies, we conduct wide areas of researchsuch as analysis of prognostic factors for liver malignancies, evaluation ofliver hemodynamics using ultrasonography, liver ischemia/reperfusion injury,
and liver regeneration.

http://www.h.u-tokyo.ac.jp/transplant/

ICGfluorescent imaging for detecting tumors

The development of a radical and safe operative procedure for hepato-biliary malignancies
The analysis of genetic abnormalities in hepatocellular carcinoma● Development of new methods for the evaluation of liver functional reserve● The evaluation of hemodynamics in the congested liver using ultrasonography● Study of the effect of ischemic preconditioning on liver normothermic ischemia/reperfusion● Study of intraoperative diagnosis (enhanced ultrasound and ICG fluorescent imaging)● Clinical trials concerning adjuvant therapies after hepatic resection for hepatocellular
carcinoma (HCC) or colorectal liver metastasis● RCT to evaluate the effects of surgical resection and RFA for HCC (SURF trial)● Investigation of adjuvant immunotherapies after surgery for pancreato-biliary malignant
tumors● Vascular reconstraction using criopreserved vein grafts● Evaluation of the anti-adhesion materials●●

Urology

Vascular reconstraction using
criopreserved vein grafts
Preoperative 3D imaging of
the liver constructed bysimulation software

http://www.h.u-tokyo.ac.jp/urology/

We constantly perform more than 1,200 urological surgeries every year, including nephrectomy, cystectomy and prostatectomy,
with increasing trend of laparoscopic maneuvers. Robotic surgery was introduced in 2011. Surgical or non-surgical means are
employed for non-cancer disease including chronic renal failure, urinary dysfunction, urinary incontinence and interstitial cystitis.
With regard to basic research and treatment, genome analysis, dendritic cell therapy, viral therapy and Botulinum toxin injection
are now under extensive investigation.
Virus therapy for prostate cancer (Fig.1)
Genome analysis of renal cancer, renal pelvic cancer, ureteral cancer and testicularcancer (Fig.2)● Bladder cancer therapy with a vaccine against NY antibody● Dendritic cell therapy for metastatic renal
cancer and bladder cancer● Botulinum toxin injection therapy for interstitial
cystitis● Artificial urinary sphincter for male urinary
incontinence● Robot-assisted laparoscopic radical
prostatectomy● Robot-assisted laparoscopic partial
nephrectomy
Fig.1 The combination therapy of oncolytic
HSV-1 with androgen ablation led to significantly● Robot-assisted laparoscopic radical cystectomy●●

enhanced inhibition of the tumor growth.

36

Fig.2 New TCEB1 mutations and HIF accumulation.

http://www.h.u-tokyo.ac.jp/transplant/

Artificial Organ and Transplantation Division
529 living donor liver transplantation and 18 deceased donor livertransplantation until June, 2013. The 5-year survival rate for adult case was 85%,
which is significantly superior to that of the national data (70%).
Surgical technique of liver transplantation: including
right lateral sector graft, APOLT(Auxillary partial
orthotopic liver transplantation)● Hepatic vein reconstraction using criopreserved vein
grafts● Identification of veno-occlusive resions using ICG
fluorescence imaging● Antiviral treatment for hepatitic C virus infection after
liver transplantation● Validity and feasibility of transient elastography for thetransplanted liver● New-onset daibetes mellitus developing in adult living
donor liver transplant recipient● Diagnosis and treatment for acute rejection● Diagnosis and treatment for postoperative infection●

Overall survivals after living donor liver trasnplantation

Hepatic vein reconstraction using
criopreserved vein grafts
Identification of veno-occlusive
resions using ICG fluorescenceimaging

Surgical Oncology

http://all-1su.umin.jp/

We have performed basic and clinical research mainly on colorectal
cancer. In basic research, we are studying biological phenomenon fromvarious point of view such as carcinogenesis, cancer metastasis, andimmunology. In clinical study, we are trying to identify the best way totreat each patient with the least surgical stress by minimally invasive
surgery such as laparoscopic surgery and robotic surgey (da Vinci), andpreoperative chemoradiotherapy for rectal cancer.
Robot assisted surgery (da Vinci robotic surgery)Radiosensitivity and chemosensitivity of cancer● Characterization of tumor vasculature and its
therapeutic application● Surveillance of ulcerative colitis● Carcinogenesis in ulcerative colitis● Cancer and autophagy● Genetic analyze of poorly differentiated colorectal
cancer● Development of chemoradioimmunotherapy● Intraperitoneal chemotherapy for peritoneal
carcinomatosis●●

Fig.1 Prediction of radio
sensitivity with DNA
microarray

Fig.2 Incidece rate of cancer
or dysplasia in patients withlong-standing ulcerative
colitis and surveillance withmagnifying colonoscopy.

Vascular Surgery

http://all-1su.umin.jp/

We had a great deal of experience in treating patients with various
vascular diseases, and we have performed much research on
atherosclerosis, angiogenesis and vascular regeneration. Based on
the research results, we are trying to identify the best way to treat
each patient with the least surgical stress.
Development of a novel method to diagnose and treat thevasculardiseases.
●
●
●

●
●
●

●

Vascular regeneration therapy for atherosclerotic obliterans
Navigation system for less invasive vascular surgery
Analysis of intermittent claudication with dynamic and mechanicalmodel
Dynamic and genetic mechanism of aortic aneurysm expansion
Development of the new prosthesis with small diameter
Hemodynamic analysis of aortic wall after endovascular aneurysm
repairDrug delivery system for aortic aneurysm and peripheral arterial
disease37

Metabolic Care and Endocrine Surgery

http://todai3ge.umin.jp/

Division of breast and endocrine surgery performs surgery
for 300 cases of breast, thyroid and parathyroid tumors ay e a r, a n d p e r f o r m s r e s e a r ch o n t u m o r i g e n e s i s ,establishment of treatment and prevention of breast andthyroid cancers. We also performs several clinical trials
concerning cancer chemotherapy.
Detection of circulation tumor cells in breast and thyroid
cancer patients● Aberrant DNA methylation in human papillary thyroid
cancer and its association with RAF/RAS oncogene
mutation● Development of a novel approach, the epigenome-based
outlier approach, to identify tumor-suppressor genes
silenced by aberrant DNA methylation● A clinical effect of a new anti-cancer drug Eriburin formetastatic breast cancer● Anti-cancer drug sensitivity test in breast cancer patientsand clinical outcome● Excision of ectopic parathyroid adenoma with intraoperative
99m
Technetium sestamibi scanning●

99m
Technetium sestamibi scintigram showing
intense accumulation of the radioisotope
in the left upper mediastinum

Computed tomographic scan showing
an ectopic parathyroid adenoma posterior
to the oesophagus

Intraoperative photograph showing radioisotope-guided navigation system with gamma probe
and the ectopic parathyroid adenoma in the posterior superior mediastinum

Dermatology

http://www.h.u-tokyo.ac.jp/der/Our department actively performs the following cutting-edge, multifaceted
research projects that will be put into clinical practice in the future.
Molecular mechanisms of immunological abnormalities and skin and lungfibrosis in scleroderma● Development of novel therapies to scleroderma, including B cell depletion
therapy● Relative contribution of various cell adhesion molecules and chemokines toinflammatory conditions● Identification of novel autoantibodies and their clinical significance inconnective tissue diseases● New roles of B lymphocytes, especially regulatory roles, in inflammatory
disorders● Immunological abnormalities of atopic dermatitis● Pivotal roles of Fli1 in systemic sclerosis● Roles of chemokines in cutaneous lymphoma●

Skin fibrosis induced by bleomycin(left) is inhibited in
CD19-deficient mice(right)

Plastic and Reconstructive Surgery
In our lab, we are investigating the mechanisms of morphogenesis ofcongenital anomalies using a developmental biological approach. In
addition, we are performing extensive research into the clinicalapplication of engineered tissues such as skin, soft tissue, andcartilage. We also have several cosmesis-related projects such as
clinical hair regrowth with cultured cells and analysis of skin aging
mechanisms.
●

Basic Research●●●

Mesenchymal stem cells derived from lipoaspirates
Organ engineering with human adult stem cells
Hair regrowth with cultured dermal papilla cells Research on aging skinrelated factors Regulation of skin aging using hormones and retinoids
Regulation of epidermis by factors derived from dermal fibroblasts
●

●

●

●

Clinical Research
●
●

●
●
●

38

Supermicrosurgical vascularized nerve graft. 100% of

Schwan cells within a nerve graft can survive with
Ultramicrosurgical reconstruction using vascularized tissue transfers
microvascular anastomosis(0.5mm).
Reconstructions for established nerve palsy Esthetic microneurovascularsurgery
Mechanism and surgical treatments of lymphedema Vascularized ovarial preservation and transplantation
Free vascularized transfers of nerve cells, muscle cells, adiposal cells, and lymphnodes
Allogenic tissue transfer (uterus, ovarium, anus etc.) Training method for supermicrosurgical anastomosis●●●

Oral and Maxillofacial Surgery

http://plaza.umin.ac.jp/˜oralsurg/

Our laboratory has been performing a wide range of clinically oriented
research in oral-maxillofacial disorders such as congenital diseases, jaw
deformities and tumors in the oral region. Cartilage and bone regeneration
using tissue engineering techniques is our main field of research.
●

Clinical research:

Treatment of facial deformities and malocclusion in patients with cleft lip/palate
Research on facial growth in patients with craniofacial anomalies
Reconstruction of oral and maxillofacial area by custom-made artificial bone (CTbone) (clinical trial) Transplantation of implant-type tissue-engineered cartilage
for cleft lip-nose patients (clinical study) Management of occlusion in patientswith fibrodysplasia ossificans progressiva (FOP) QOL study of oral health caresystem in preoperative cancer patients Clinical study of antifungal susceptibility
in patients with oral candidiasis

●

●

●  

●

●

●

●

●

Basic and experimental research:

Regeneration of bone and cartilage with tissue-engineering approach Development of intelligent artificial bone with the ability ofbone induction Development of micro-tetrapod bone implant Molecular biology of cartilage repair and its application to cartilage
regenerative medicine Cartilage regenerative medicine using iPS cells Development of novel scaffolds for cartilage and boneregeneration In vivo evaluation of tissue-engineered cartilage and bone Study on the control of mesenchymal cell differentiation
Elucidation of epigenetic abnormalities in oral cancers and oral premalignant lesions Elucidation of sphingosine-1-phosphate signaling
and its role in multistage oral cancer Functional analysis of microRNAs in human dental pulp stem cells

●

●

●

●

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●

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Orthopaedic Surgery

http://www.u-tokyo-ortho.jp/

Our department was established in 1906 as the first department oforthopaedic surgery in Japan. Since then our efforts have been dedicated toresponding to the needs of patients for orthopaedic care and to related
research. Our department seeks to elucidate the molecular and genetic
backgrounds of bone and cartilage disorders in order to develop
groundbreaking treatments for these conditions. At the same time, we areattempting to establish various clinical devices.
Systemic and comprehensive study for osteoarthritis
Bone, cartilage and nerve regeneration
Surgical navigation system● Regulation of anabolic and catabolic bone metabolism by cytokines● Molecular mechanism of age-related bone loss
● Molecular mechanism of osteoclast differentiation and apoptosis (RANKL-RANK, INF, Src)
● Gene therapy to control pathological bone destruction (arthritic bone resorption and arthritic joint destruction)using adenovirus vectors● Non-invasive analyzing system to evaluate the mechanical properties of skeletal system in vivo using CT based
finite element analyses● Surgical navigation system with a three-dimensional display and navigation robot●●

Ophthalmology

http://plaza.umin.ac.jp/oph/

Our department applies cutting-edge technologies and knowledge todiagnosis and treatment of eye diseases. To elucidate pathogenesis andestablish more efficient ways of diagnosis and treatment of various
refractory eye diseases, basic researches utilizing molecular biological,
immunological and/or pharmacological techniques and clinical studies
utilizing epidemiological, biostatistical and/or optical methods are
conducted. Our efforts are also dedicated to regenerative medicine of thecornea and retina.
Investigation of primary glaucomas and relating factors
Development of new methods of glaucoma treatment and validation by RCT● Investigation of new ocular hypotensive drugs and their mechanism of action
by using transgenic or KO mice or experimental glaucoma monkeys● Investigation of mechanism of neural cell death by using cultured RGCs or
retinal glial cells and exploratory search for new neuroprotective agents● Analysis of ocular circulation in glaucoma and retinal diseases● Analysis of corneal topography and wave-front analysis of optical aberrations● Development of tissue-engineered cornea by using cultured stem cells of corneal endothelium and epithelium● Investigation of molecular mechanism of choroid-retinal neovascularization and new drug delivery system for it utilizing
nanotechnology● Regenerative medicine of the retina using retinal stem cells● Investigation of immune responses in rejection of transplanted cornea and role of chemokines and receptors in uveitis●●

39

Otorhinolaryngology and Head & Neck Surgery

http://www.h.u-tokyo.ac.jp/orl/

Our research is composed of both clinical and basic research. Clinical research is
conducted by specialized clinics in the hospital, which experience ear diseases andhearing disorders from neonates to adulthood, head and neck cancer, paranasal
diseases, olfactory and disorders, vertigo and balance disorders and voice andswallowing disorders. Basic and experimental research into molecular biology,
electrophysiology and morphology is conducted in our department's laboratories.
●
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Clinical researchCochlear implantation in deaf children and their development of hearing, speech and language
Surgical correction of congenial microtia and atresia and postoperative radical ears to improve
hearing
Quality of life in patients with head and neck cancer to restore speech and swallowing function
Vestibular research on the oculomotor and balance system and myogenic potential
Navigation of the paranasal sinuses and skull base surgery
Surgical treatment of voice and swallowing disorders
Basic and experimental research
Molecular biology of the inner ear
Molecular biology of pharyngeal cancer
Molecular biology of differentiation and development of inner ear and olfactory epithelium
Origins of vestibular myogenic potential
Aging and regeneration of olfactory epithelium
Physiology of vocal cord vibration

Chochlear implant

Rehabilitation Medicine
Our research purpose is to improve the provision of a unique andcomprehensive rehabilitation service enabling people to develop
their full potential and often returning from being a "patient" to beinga "person". Clinically oriented studies concentrate on elucidation of
the origin of disabilities to cause activity limitation and restriction ofparticipation.
●

Gait analysis
●
●
●

●

Clinical research on intractable rare diseases
●
●

●
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3-dimensional image analysis with a infrared camera system
Measurements of 3 dimensional ground reaction forces with a force platform
Measurements of foot pressures with a computerised pressure sensor
Fibrodysplasia Ossificans Progressiva
Congenital Insensitivity to Plan

Clinical research on congenital limb malformations
Research on the effect of physical therapy in locomotive syndrome

Anesthesiology

Gait analysis

http://www.anes.umin.ne.jp/

We have seven research groups and their fields include respiration, circulation, pain, immune system and shock.
These are recent major subjects of our research.
Respiratory system: A role of cytokine signaling in acute lung injury;
Exploring optimal ventilatory strategy for respiratory failure● Immune systems: Modification of immune system by anesthesia; Signaltransduction pathway related to apoptosis induced by sepsis or ischemiareperfusion injury● Shock: Investigation of pathophysiology of shock; Effect of new plasma
substitutes on hemorrhagic shock.
● Inflammation: A role of lipid mediators in organ damage mediated byischemia-reperfusion injury of a mouse lower limb.
● Pain: A role of lipid mediators in the formation of hyperalgesia; A role ofspinal microglial cells in the development of inflammation-mediatedneuropathic pain; Mechanism of pruritoceptive and neurogenic Itch;
Anesthesia and monitors
Cognitive-behavioral therapy on chronic pain.
● Nervous system: Analysis of electroencephalography during general anesthesia; Clinical evaluation of neurological sequelae
after cardiac surgery; Evaluation of neuroprotective properties of anesthetics.
● Anesthesia apparatus and other medical equipment: Invention and validation of a new airway device; Development andassessment of the system for treating waste anesthetic gases● Glucose metabolism: Effect of anesthetics on glucose metabolism in vivo
● Epidemiological survey and outcome study with large administrative database.
●40

Emergency and Critical Care Medicine

http://plaza.umin.ac.jp/todaiqq/

We are developing emergency department information
systems designed specifically for use in emergency
departments. This systems will increase the efficiency of
emergency medical care, leading to an accumulation ofknowledge and an advancement of epidemiological researchin Japan. Furthermore, we are collaborating with the Schoolof Engineering, and now developing new medical device andmonitoring system.
Emergency Department Information Systems
Vital Care Network System● Telemonitoring system for prehospital medicine● High-performance transfer system for the ambulances●●

41

Health Sciences and Nursing

Mental Health / Psychiatric Nursing
Our departments conduct research on mental health and psycho-social
stress and provide education/ training of professionals in related fields
from global perspectives.
Mental Health

●

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Mental health epidemiology
Occupational mental health/Occupational health psychology
Psychoeducation/Stress management
Disaster and mental health
Global mental health
Practice and Evaluation of Psychotherapy
Early detection and therapeutic education of Pervasive Developmental
Disorders

Psychiatric Nursing

●

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Supporting people living with mental health problems
Wellness self-management in mental health
Recovery for people with mental illness
Patients' satisfaction with psychiatric services

Biostatistics / Epidemiology and Preventive Health Sciences
Biostatistics and epidemiology provide the methodological basis forhealth sciences. We are conducting basic methodological research of
biostatistics and theoretical epidemiology as well as consultation works
and collaborative projects with basic/clinical researchers. The NPO"Japan Clinical Research Support Unit" established by the staff of thedepartment is supporting investigator-initiated clinical trials and largescale epidemiological studies in respect of data management, statistics
and quality assurance.
●

Methodological research
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●

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Design of clinical trials
Analysis of correlated data and longitudinal data such as QOL data,
multiple recurrence (events) data
Causal inference

Collaborative projects
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42

Japan Arteriosclerosis Longitudinal Study
Comprehensive Support Project for Oncology Research- Breast Cancer
Comprehensive Support Project for Adequate Treatment of Osteoporosis
Other investigator-initiated clinical trials

http://www.epistat.m.u-tokyo.ac.jp/

Nursing Administration / Advanced Clinical Nursing

http://nurs-adm.umin.jp/

Our research programs aim to support clinical nurses in providing highquality care for their patients in efficient way. Under a nation-wide
healthcare reform, improving the efficiency of healthcare delivery
systems becomes essential. For nursing care, assessing the efficacy
and the putting in place of quality assurance systems are required.
Applying management theories to nursing administration, we focus on
nursing quality improvement, nurse staffing, patient classification
systems, budgetary management, staff development and continuing
education.
Evaluation and improvement of quality of nursing care
Benchmarking of nursing quality indicators● Outcome management for nursing practice● Risk management● Human resources management● Nursing case management and critical pathways● Effect of care environment on patients● International comparison of nursing quality indicators● Nursing policy and economics●●

Promoting quality nursing care

Family Nursing
Hand-in-hand with the changes occurring in society, such as declining birthrate
and a growing proportion of elderly people, vulnerability of regional network,and gender-equal society, the conformation and the function of the family arealso changing. Current Japanese society expects not only client-centeredperspective but also a perspective to refer family as ‘client’ in the nursing
research. We are especially performing research on childrearing issues andcaring for child with illness.
Postnatal depression and difficulties in childrearing.
Prevention of child abuse and neglect.
● Development of Pediatric QOL Inventory for child with chronic illness and theirparents.
● Late effect of treatment and posttraumatic stress symptoms in children with cancer.
● The role and expertise of the nursing staffs in daycare centers.
● Primary caregivers’ burden of the severely disabled children and the utilization of therespite care.
● Care for dying patients and their families (QOL, family function).
●●

Community Health Nursing

http://park.itc.u-tokyo.ac.jp/chn/english/index.html

The goal of our department is to continuously maintain and improve thehealth and quality of life of people regardless of their life stages andhealth statuses, by taking advantage of the characteristics of a target
community or population and constructing the system. Also, we cover
the research on skills of public health nurses who are the provider ofcommunity health care.
Construction of community health care system
Community health care for maternal and child health/ mental health/elderly’s health● Community health nursing for disaster prevention and recovery● Skills of public health nurses●●

Research of community health nursing

43http://www.adng.m.u-tokyo.ac.jp

Adult Health Nursing/ Palliative Care Nursing
Our research activities are targeted at quality assurance/improvementof nursing care of those with chronic conditions, older adults as wellas their family members. 1) Developing theoretical frameworks thatguide nursing care by explaining the nature of illness/aging
experience and experience of taking care of others. Focusing on
chronic conditions such as dementia, cancer, pain or end-of-life, we
aim at advancing knowledge grounded at nursing activities in Japan.
2) Developing quality improvement systems for nursing/healthcare in
long-term care facilities, outpatients, and home healthcare. We focus
on care of such conditions as pain, dementia, or stem-celltransplantation, as well as families.
Developing quality indicators for gerontological homecare nursing
Developing IT-based nursing care/educational programs● Inter-professional collaboration for home end-of-life care
● Outpatient nursing care for clients with hematopoietic stem celltransplantation● Quality assurance/improvement of care in the long-term care system● Homecare nursing for those with dementia and their family● Developing a community care system and nursing role
● Nursing care to improve QOL of persons with cancer●●

Midwifery and Women's HealthFamily caregiver strategies to encourage older relatives withdementia to use social services

http://park.itc.u-tokyo.ac.jp/midwifery/index-e.html

The physical and mental changes that occur during the perinatal period have a criticalinfluence on women’s health for their entire lives, including the child-rearing years,
menopause, and old age. In addition, the influence extends to their children, family, andcommunity. Specifically, our department focuses on the health of mothers and babies in
the perinatal period, and mainly performs research in the following areas.
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Lifestyle in the perinatal period
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Mental health in the perinatal period●●

Effects of prenatal lifestyle modifications on oxidative stress as biomarkers
Effects of exercise (yoga) during pregnancy on physical and mental well-being
Development of intervention methodology for improving dietary and weight management
during pregnancy and postpartum
Health support for working women in the prenatal period and the child-rearing period
Effects of fear of childbirth on physical and mental well-being among prenatal and postnatal
women

Identification of health problems in the perinatal period
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Physical and mental conditions of pregnant women suffering from intimate partner violencePrevalence of dysfunction of the pelvic floor muscles in the postpartum period and theidentification of risk factors
Usage of maternal and child health handbooks in Mongolia
Relationship between the skin barrier function of infants and skin lesions
Disaster management in perinatal care

Gerontological Nursing / Wound Care Management

Photo by Sakae Kikuchi

http://www.rounenkango.m.u-tokyo.ac.jp/
english/index-e.html

Pressure ulcers and diabetic foot ulcers usually occur in elderly people
due to basic activities of daily living such as walking, sleeping, diet andexcretion. Thus their supports are inevitable for comprehensive woundcare management. Especially, diabetes mellitus, nutrition, and skin careare of importance for wound healing, hence we account for these keys todevelop wound care technologies and devices. Our department address
the new concept of nursing science, ”Bioengineering Nursing”, in which
the basic science will be translated into clinical science throughco-development of new technologies and devices with specializedengineers.
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Development and evaluation of wound management technology anddevices
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44

Elucidation of pathophysiology and its diagnosis technology of wound
Development of technology and devices for wound management andprevention
Evaluation of new technology and devices
Investigation of bioengineering aspect of elderly skin
Exploring of objective parameter of skin status
Development of intervention methodology for improving skin function

Example of Bioengineering Nursing research in our department.
–Investigation of mechanism for deep tissue injury and its
effective management strategy–Health Sciences and Nursing
Health Sociology See Health and Social Behavior(p50)
Health Education See Health and Social Behavior(p50)
Health Promotion Science See Health Promotion Sciences(p51)
Biomedical Ethics See Biomedical Ethics(p51)45International Health

Global Health Policy

http://www.ghp.m.u-tokyo.ac.jp

Our mission is to improve population health by enhancing accountability and improving the evidence base of global (bothdomestic and international) health programs through the provision of the best possible information and rigorous
monitoring and evaluation. The department's members generate knowledge and ideas through their research with highsocial and academic impacts, strengthen technical and leadership skills through educational programs, and enhancenational capacities through collaborative projects, especially in the developing world.
The priority areas of research are:
● Global Burden of Disease (GBD)● Health System Performance Assessment● Domestic Health Policy Reform● Inequality and Inequity in Health● Infectious Disease Modeling● Non-Communicable Diseases● Health Technology Assessment and Health Innovations● Radiation Exposure and Health in Fukushima

Community and Global Health
Our department acts for health and wellbeing of socially vulnerable
people. Health itself is not necessarily our ultimate goal. How anindividual can dream and reach her/his ultimate goal in life by making thebest use of his/her health? This is more critical. We study and teach how it
can be done in global settings. When any interventions are implemented,
we continue to ask who receives real benefits from them.
Health and wellbeing
Health and sustainable development● Health promotion● Ecology and infectious disease control●●

46

http://www.ich.m.u-tokyo.ac.jp/en/index.html

Human Genetics

http://www.humgenet.m.u-tokyo.ac.jp/

Department of Human Genetics is broadly interested in thehuman genome diversity, especially in the Asian populations.
Specifically, we are using genomic research tools including SNP
and microsatellite analyses, as well as gene expression profiling,
to better understand the genetic background of a variety ofcomplex diseases, especially bone and joint diseases, infectious
diseases and sleep disorders.
●Theoretical and experimental analyses on the genetics of complex
diseases
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Development of statistical approaches for susceptibility gene
mapping in complex diseases
Comprehensive genetics of bone and joint diseases
Host susceptibility factors to infectious diseases
Molecular mechanisms of sleep disorders

Development of new methodologies for genomic polymorphism
Analysis on the genome diversity of Asia-Pacific populations● Development of methodologies for the analysis of protein
interactions●●

Developmental Medical Sciences
Founded in 1966 as the Department of Maternal and Child Health,this department has devoted itself to the research and education on
the maintenance and promotion of mothers' and children's health,including studies of infectious diseases, nutritional disorders andcongenital anomalies. At present, the main research activities areexperimental and epidemiological studies on the etiology (genetic
and environmental factors), pathogenesis, prevention andtreatment of various childhood brain disorders (congenital andacquired) that cause mental and motor disabilities and epilepsy,
from the viewpoint of international health science anddevelopmental neuroscience.
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Studies on developmental brain disorders
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Inhibition of doubledortin expression by shRNA reduces the distanceof neuronal migration from the ventricular zone to cortical plate.
Abnormal neuronal differentiation and size control (tuberous sclerosis)
Neuronal migration disorders (lissencephaly, polymicrogyria)
Perinatal brain injury (periventricular leukomalacia)
Postnatal brain injury (acute encephalopathy)
Inherited metabolic disorders (peroxisomal and mitochondrial disorders)

Molecular epidemiology of infectious diseases (diarrheal viruses)● Field studies of maternal and child health (malnutrition, obesity)●

Human Ecology

http://www.humeco.m.u-tokyo.ac.jp/

Ecological understanding of health and survival of contemporary humanpopulations through the analyses of nutritional, demographic, andenvironmental aspects of each population is our primary goal. Bothfieldworks on various Asia-Oceania populations as well as experimental
studies dealing with nutrition and environmental chemicals are conducted,
which would serves as the basis in challenging the International Healthissues.
Mechanistic analyses of the effect of subsistence transitions on the healthand environment in rural and urban communities in developing countries● Application of GPS, GIS, and remote sensing to health ecology andinternational health
At a school in a survey area, West Java, Indonesia● Exposure-effects evaluation of chemical pollution of watershed in rural
Indonesian children● Nutritional ecology, subsistence ecology, medical anthropology and biological demography in Asia-Oceania populations● Development effects of perinatal exposures to heavy metals, pesticides, or endocrine disrupting chemicals● Modulating effects of nutrients and nutritional status on environmental hazardous chemicals● Sustainable society and health●47

Biomedical Chemistry
The aim of our department is to contribute to the overall global health andwelfare through basic research. Our current interests are: the energy
metabolism of humans, parasites, and bacteria; and RNA and RNA-binding
proteins.
Human succinate dehydrogenase complex and mitochondrial myopathy
Ascaris suum and Caenorhabditis elegans● Molecular mechanism of adaptation to low oxygen tension● Mitochondrial quinol-fumarate reductase● C. elegans as a model system of parasitic nematodes and ageing● Malaria and Trypanosome: characterization of mitochondria as a target forchemotherapy● Escherichia coli and Mycobacterium: respiratory enzymes and regulation ofenergy supply● RNA and RNA-binding proteins● Mitochondriral translation system● RNA biogenesis of Eukarya and Archaea●●

48

Structure of cyanide insensitive alternative oxidase, which
is a promising target of anti-sleeping sickness, with drugcandidate ascofuranone. This is a first report on themembrane-bound diiron proteins.

School of Public HealthSocial and Preventive Epidemiology
Our main research field is preventive epidemiology onlifestyle-related diseases. This department is unique inJapan since our core research field is "nutritional
epidemiology", which epidemiologically examines theroles of diets for disease prevention and control.
Methodological studies on dietary assessments
Nutritional epidemiologic studies on nutrient intakes/
dietary
behaviors and health status● Studies on development of dietary promotion methods
andevaluation of their effectiveness● Establishment of literature database for "epidemiologic
studies on diets and health"● Collaborative studies with clinical trial groups on nutritionrelated diseases●●

Health Economics and Epidemiology Research
The department purports to help students become ahealth service practitioner with a sound theoretical andscientific ground underscored by quantitative methods of
epidemiology and economics. The department will also
contribute to the society through conducting empiricalassessment of health practice and policy on the themes
such as;Economic assessment of medical technology
Clinical evaluation through patient-derived outcome● Standardization and management of quality of care
● Health policy assessment● Health impact of socio-economic policy
●
●

Japan

USA

Japan

USA

Comparison of quality of primary care; Japan vs. U.S. Hashimoto, et al. Lancet 201149

Health Communication
The Department of Health Communication conducts research on the
University hospital Medical Information Network (UMIN) Center related
activities as well as health communication research at various levels.
Main research topics include;● Communication of health information to general public● Patient-provider relationship and communication● Health literacy● Activities related to the UMIN
● Information systems for clinical epidemiologic studies● Security of the information network

Mental Health

http://plaza.umin.ac.jp/˜heart/

The Department of Mental Health has engaged in education andresearch on a wide range of topics related to mental health, such associal determinants of stress and mental health, and prevention ofmental disorders and suicide. The Department provides classes ofMental Health I (epidemiology and countermeasures in mental
health) and Mental Health II (occupational mental health).
Community-based mental health epidemiology
Occupational mental health● Positive mental health and well-being● Stress management● Disaster and mental health● Global mental health●●

Health and Social Behavior
The unit follows the legend of former departments of health sociology,
health education, and social gerontology, and extends its academic
endeavor to empirically reveal complex mechanisms between social
structure/relationship and individual health/behavior. Throughinterdisciplinary and global communication with social science andhealth science, the unit aims at exploring research and education onsocial determinants of health, such as;Trans-generational health impact of socioeconomic status
Health impact of retirement and social participation among the elderly● Policy intervention design to alleviate social exclusion● The impact of healthcare systems for health equity● Social experiences of chronically ills and their health●●

50

The UNU-IIGH/UNDESA/the University of Tokyo Expert Meeting on
Mental Well-being, Disability, and Development in Kuala Lumpur,
Malaysia, April 2013

Health Promotion Sciences

http://www.ethps.m.u-tokyo.ac.jp/

The department aims to develop scientifically effective and usefulhealth promotion activities and systems to prevent lifestyle-relateddiseases, and to contribute to society, conducts research andeducation concerning the methods of planning, implementationand evaluation for various health promotion activities.
Specific research topics include:● Development of effective health promotion programs incommunities, worksites, and schools● Assessment of the supportive environments for health behaviors● Evaluation of the supporting methods for health behaviors● Short- and long-term effects of behavior change● Social and physical environments that influence health behavior andhealth status
http://www.ethps.m.u-tokyo.ac.jp/HPS/

Biomedical Ethics

Average numberof walking steps(over 20 years
old male)Prevalence ofobesity(over 20 years
old male)

The number ofowned private cars(per household)

http://www.ethps.m.u-tokyo.ac.jp/

The Department of Biomedical Ethics conducts both theoreticaland empirical studies in the fields of biomedical ethics, research
ethics and clinical ethics. Research topics include ethical theories,
informed consent, ethics committees and organ transplantation.
The Center for Biomedical Ethics and Law (CBEL) was recently set
up as an adjunct to the Department of Biomedical Ethics.
(http://www.cbel.jp/)
Study of the functions and responsibilities of ethics committees in
Outreach Program: CBEL provides training courses for ethics committeeJapan
members. Participants include physicians, nurses and medical● Study of the methods for the formation of social consensus related
pharmaceutical representatives.
to advanced medical technology● Comparative study of clinical ethics in the Asian region● Acceptability of advance directives in Japan● Development of evaluation methods for biomedical ethics education● Psychosocial and ethical aspects of living related organtransplantation●

Health Policy
Health Policy is the academic fields in which scientificevidence is collected, established, accumulated, anddisseminated for health policy making. Through studies invarious aspects in health policy, our department aims toadvance research, support policy development, andpromote education toward these ends. This department is
concurrently operated with Department of Public Health.
Efficiency and equity issues of health systems
Health manpower policy● Occupational and environmental epidemiology● Health services research

http://publichealth.m.u-tokyo.ac.jp/

1980 cohort (male)	

1980 cohort (female)	

1990 cohort (male)	

1990 cohort (female)	

●●Physician workforce participation rate by age and gender in Japan

51

Healthcare Informatics

http://www.m.u-tokyo.ac.jp/medinfo/

The department conducts the practical education and researchon various issues about design, development andimplementation of healthcare information systems as well as
electronic health record systems. These issues cover broad
range of topics regarding healthcare informatics as follows:
basic infrastructure of healthcare information systems androles there, organizational theories, information management
and its ethics and standardization. Solutions of various
problems for promoting ICT in clinical fields are also targeted.
Since both the education-research section and the practicalmanagement section in the department are organized as asingle unit, students can benefit from education in many ways
in the environment of practical system management field.
Integration and big-data analysis of healthcare database
Medical knowledge extraction using natural language
processing● Development of clinical ontology● Development of real-time monitoring for patient safety●●

Clinical Information Engineering

Integrating multi-institutional healthcare data and medical ontology

http://home.cie.m.u-tokyo.ac.jp:8080/ciemutk

Clinical Information Engineering focuses on computer applications
that address biomedical data (collection, analysis, representation). It
is a combination of information science, computer science, andclinical science designed to assist in the management andprocessing of data, information and knowledge to support thepractice and delivery of clinical care and public health.
CDecM: Clinical Decision Making (PEC model)
ClinBi: Clinical Bioinformatics: Data Mining & Knowledge Discovery
in Database● ClinVR: Clinical Interactive 3D Computer Graphics & Virtual reality● PHI: Social information engineering for Public Health (Public Health
Informatics: GIS for Health Science etc.)●●

A methodology of neuroscience using virtual reality

School of Public Health
Biostatistics See Biostatistics / Epidemiology and Preventive Health Sciences(p42)
Health Sociology and Health Education See Health and Social Behavior(p50)
Forensic Medicine and Medical Law See Forensic Medicine(p27)52

Center for
Disease Biology and Integrative Medicine

Molecular Biomedicine for Pathogenesis

http://www.cdbim.m.u-tokyo.ac.jp/
english/index.html

Our laboratory focuses on clarification of the pathogenesis ofvarious diseases and the related physiological machineries incellular and molecular aspects. Based on our technical advantage
in gene manipulation via gene knockout and transgenesis, wegive high priorities to in vitro analyses. Our overall goal is to
apply our findings to develop a fundamental therapy against
diseases via AIM (Apoptosis Inhibitor of Macrophage).
Roles of AIM molecule in pathogenesis of metabolic disorders
including obesity, diabetes, and atherosclerosis● Involvements and roles of AIM molecule in diseases other thanmetabolic disorders, such as infertility, autoimmunity, and cancer● Development of the direct therapeutic application of our findings●

Structual Physiology

http://www.bm2.m.u-tokyo.ac.jp/index-e.html

We have been exploring two-photon excitation microscopy, which
utilizes an infrared femtosecond-pulsed laser as a light source, tovisualize and stimulate intact tissues at the cellular and molecularlevels. We focus on the functions and disorders of the brain andsecretory organs.
The dynamics of synapses in the cerebral cortex, in relation tomemory, cognitive processes and mental disorders● Molecular mechanisms of exocytosis in synapses and the islet of
Langerhans, and their optical control●

Fine structure and function of a central neuron studied
with two-photon excitation imaging and uncaging

53http://www.cdbim.m.u-tokyo.ac.jp/

Regenerative Medical Engineering
We aim to create a basic methodology for tissue engineering by integrating
engineering sciences such as mechanical, material, and chemical systemengineering into basic and clinical medicine. Especially for the regeneration ofbones, cartilages, and blood vessels, we focus on cellular response to physicalstimulations, which can be utilized instead of growth factors and cytokines. In
addition, fabrication of new biomaterials is important. We develop new
biocompatible hydrogels based on polysaccharides, hyperbranched polymers,
and DNA analogues, which materials are applied to drug delivery systems for
peritoneal diseases, artificial red blood cells, and artificial pancreas islets.

Ushida Lab

Ito LabDevelopment of new polymeric and inorganic biomaterials for regenerative
medicine● In vitro regeneration of carriages, bones, and small blood vessels● Mechanism of cellular response to physical stimulations● Fabrication of new biocompatible hydrogels● Development of anti-peritoneal adhesion barrier and drug delivery system for
peritoneal diseases● Development of artificial pancreatic islet by a microcapsulation technique, anddevelopment of artificial red blood cells by a membrane emulsification technique●

Clinical Biotechnology

http://www.bmw.t.u-tokyo.ac.jp/english/index.html
http://www.cdbim.m.u-tokyo.ac.jp/english/research/04.php"Medical nanodevices", which are constructed by integrating
medical materials and systems, hold promise for the futuristic
medical system that can serve the needed function at the righttime and the right place with minimal invasiveness. Our division
wishes to produce innovative medical nanodevices based on
nanobiotechnology, and further, to spread the idea of"Nanomedicine" intranationally and internationally.
Construction of multifunctional nanodevices based on selfassemblies of synthetic polymers● Targeted cancer therapy with anticancer drug-loaded nanodevices● Study on the packaging mechanism of plasmid DNA with block
catiomers for creation of artificial viruses● Development and applications of polyion complex-based vesicular
nanodevices●

Environmental Health Sciences

http://env-health.m.u-tokyo.ac.jp/english.html

Children's health problems of today include such conditions as
disorders in the reproductive and immune functions, learning
deficits, mental problem and metabolic syndrome. Our research iscarried out on the recognition that the homeostasis is disrupted byvarious environmentally hazardous chemicals, to which expectant
mothers and their newborn babies are exposed during theirhighly sensitive period of life, and that the contamination withthese chemicals may lead to various disease conditions in children
after birth. Our experimental investigations are focused on thefollowing themes.
Elucidation of mechanisms involved in the manifestation of
toxicity at the molecular and cellular level due to exposure toenvironmental pollutants, such as dioxin/PCBs and heavy metals● Clarification of epigenetic mechanisms that alter susceptibility toenvironmental chemicals● Development of methodologies for evaluating the toxicity ofchemicals to the learning and emotion of rodents and of in vitro toxicity techniques at the molecular and cellular levels● Development and application of techniques and methodology for evaluating risks of toxic substances in formulating safety
standard for the environment and food●54

Animal Resources / Research Resources and Support - Animal Research
Our laboratory focuses on understanding the molecular mechanisms
which underlie the brain function and cancer development. We also
try to generate animal models for human genetic diseases. Recently
we established the gene targeting methods using CRISPR/Cas
system. We also manage the animal facilities, provide reproductive
technology service, advice on animal experiments, and give lectureson laboratory animals so that animal experiments are carried out inaccordance with animal welfare.
Molecular analysis of brain function and cancer using geneticallymodified mice
● Development of new model animals for human diseases● Development of gene targeting animals using CRISPR/Cas system●

A mutant mouse lacking metabotropic glutamate receptor
subtype-1 (mGluR1)

Molecular Radiology / Reserch Resources and Suport-Radiation Biology

http://www.cdbim.m.u-tokyo.ac.jp/
english/index.html

We are investigating the molecular mechanisms of DNA double-strand
break repair as the scientific basis of radiation therapy andchemotherapy in medical oncology. We also promote the basic researchthat contributes to the development of a novel therapeutic strategy byexamining a link of the DNA metabolic network including DNA
replication and cell cycle control with chromosome instability.
Molecular mechanisms of homologous recombinational repair
Mechanisms of the choice between homologous recombination andnon-homologous end-joining● Molecular mechanisms of DNA rereplication● Mechanisms of the genesis of aneuploidy● Functional analysis of meiotic recombination genes●●

Centrosome fragmentation which may lead to aneuploidy

Research Resources and Support-Bioinformatics

http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

Targeting biomedical research support using information technologies,
the division performs management of the research network and thecentral servers of the Graduate School of Medicine, and researches onknowledge infrastructure and processing techniques (e.g. information
model, ontology, natural language processing, machine reasoning,etc.) and their application to clinical practice.
Biomedical research support using network system
Medical terminologies and ontologies● Standardization of healthcare information and information models● Natural language processing and its application to the medical domain● Machine reasoning and clinical decision support systems●●

Computer System for Biomedical Research

55

The International Research Center
for Medical Education

Department of Medical Education Studies
Faculty and staff in this department do research on a wide range of
topics in undergraduate and postgraduate medical education.
One goal is to move this field of inquiry forward by putting into
practice the information obtained from action-oriented researchdone with full appreciation of the trends in international research on
medical education. This department also makes important
contributions to undergraduate and postgraduate medical curricula,in ways that promote the development of research-minded andclinically skilled medical practitioners who can meet and exceed thehighest international standards and can become global leaders.

Lecture by Prof.Kitamura

International Cooperation for Medical Education
This department is to aim at participating international cooperation
projects in medical education area and conducting practical researchand development through activities mainly in Asian countries.
Furthermore the department domestically and internationally collects
information and expands human exchanges regarding international
cooperation in medical education area, and supports projects related
to medical education.

PBL class in Kabul Medical University, Afghanistan

56

Institution

The Office of International Academic Affairs

http://koryu.m.u-tokyo.ac.jp/homepage10.html

The Office of International Academic Affairs is under the direct authority of the
Dean of the Graduate School of Medicine. Its four most important roles, as
defined by the Committee on International Academic Affairs, are i) international
educational exchange, ii) international contacts in research and scientific fields,iii) helping young researchers excel not only as scientists, but also as educators
for the next generation and as administrators of their research groups, and iv)
holding Medical English classes and developing language-teaching materials
for medical students.

Medical Library

http://www.lib.m.u-tokyo.ac.jp

The University of Tokyo Medical Library was opened in 1961 as a model of theJapanese modern medical library. The view makes it a perfect place toconcentrate on study.
The library has adopted an open stack system so that users can have directaccess to almost all the materials.
Holdings:
Books(number of volumes) : 289,766 (Japanese 115,929 Foreign 173,837)
Periodicals(number of titles) :5,208 (Japanese 3,021 Foreign
2,187)● Visitors: 74,905● Borrowed Books: 11,361●

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Medical Scientist Training Program
Medical Scientist Training Program was launched in 2008, aiming that
medical students have the opportunity to experience basic medical
research in their early years and learn the attitude as a researcher.
Students taking this program will attend activities such as journal club,medical English course, an assignment to the lab, and FQ, during their
free time in addition to their usual curriculum. Students are also
expected to build up a network among medical students who intend to
be a researcher through the program support, such as the short term
stay at labs abroad, participations to the symposium, and the excursion
with other universities.

Museum of Health and Medicine
Museum of Health and Medicine was planned as part ofcommemorative projects to celebrate the 150th
anniversary of the founding of the School and the
University of Tokyo Hospital, and was opened on January
20, 2011. The first permanent exhibition was a display of
medical archives and instruments from the early Meiji
era, Ishihara’s Color Blind Test Charts and a gastroscope
developed at the University. Special exhibitions areplanned to promote understanding among the publicregarding advances in medical science and health care.
Following the first special exhibition is related to thebeginnings of the School and the Hospital, entitled "theChallenge to Infectious Diseases", four special exhibitions
which introduced blood vessel, cancer, brain, locomotive
syndrome were held.
We will hold two special exhibitions every year andspecial events for our visitors.

Office for Research Ethics Support
The Office for Research Ethics Support (ORES) aims to protect the rights,
health, and dignity of research participants. Based on this principle, ORES
supports researchers at the Graduate School of Medicine, the Faculty of
Medicine and the University Hospital to perform their studies in an ethicalmanner. Our primary task is the management of the Ethics Committee
secretariat. Additionally, we plan and manage research ethics seminars,
provide ethics education to researchers through consultations, develop humanresources for future research ethics specialists, and conduct related researches.

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http://www.ut-mdres.umin.jp/

Ikenohata Gate

Nurce Dormitory

East ClinicalResearch Bldg Inpatients' Ward

Central Bldg.
(East wing)

ClinicalResearchCenterHospitalFirst
Research
Bldg.

Inpatients'
Ward A

Central Bldg.
(South wing) Central Clinical
Service Bldg.1
Central Clinical
Service Bldg.2

Administration &Research Bldg.
Outpatient
Clinical Bldg.

Facility Center
Bldg.
No.4
South ClinicalResearch Bldg

MedicalLibrary
International
ResearchCenter for
Medical
Education
International
ResearchCenterBldg. No.2

Bldg.
No.5
Bioscience
Reseach Bldg.
Experimental Research Bldg.
Bldg. No.1

Akamon(Gate)

Bldg.
No.3
Annex of
Bldg.
No.3

Kohei Miyazono
Dean, Faculty of Medicine, Graduate School of Medicine
The University of Tokyo
Address:7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
http://www.m.u-tokyo.ac.jp

Issued on Sept. 1, 2013