1. Department of Virology I

6) Fujita R, Ejiri H, Lim CK, Noda S, Yamauchi T,
Watanabe M, Kobayashi D, Takayama-Ito M, Murota

1) Azami NAM, Moi ML, Ami Y, Suzaki Y, Lim CK,
Taniguchi S, Saijo M, Takasaki T, Kurane

K, Posadas-Herrera

G, Minami S, Kuwata R,

I.

Yamaguchi Y, Horiya M, Katayama Y, Shimoda H,

neutralizing

Saijo M, Maeda K, Mizutani T, Isawa H, Sawabe K.

antibodies induced by dengue virus infection: detection

Isolation and characterization of Tarumizu tick virus:of antibodies with different levels of neutralizing

A new coltivirus from Haemaphysalis flava ticks inactivities

Japan. Virus Res 242:131-140, 2017

Genotype-specificagainstandcross-reactive

homologous

andheterologous

genotypes of dengue virus type 2 in common

7) Fujii H, Kakiuchi S, Tsuji M, Nishimura H, Yoshikawa

marmosets (Callithrix jacchus). Virol J 15(1):51, 2018

T, Yamada S, Omura N, Inagaki T, Shibamura M,

2) Baba M, Toyama M, Sakakibara N, Okamoto M,

Harada S, Taniguchi S, Saijo M. Application of

Arima N, Saijo M. Establishment of an antiviral assay

next-generation

system and identification of severe fever withacyclovir-resistant herpes simplex virus type 1 variants

thrombocytopenia syndrome virus inhibitors. Antivir

at low frequency in thymidine kinase gene of theChem Chemother 25(3):83-89, 2017

isolates recovered from patients with hematopoietic

3) Egawa K, Shimojima M, Taniguchi S, Nagata N, Tani
H, Yoshikawa T, Kurosu T, Watanabe S, Fukushi S,

sequencing

todetectstem cell transplantation. J Virol Methods 251:123-128,
2018

Saijo M. Virulence, pathology, and pathogenesis of8) Fukuhara T, Tamura T, Ono C, Shiokawa M, Mori H,

Pteropine orthoreovirus (PRV) in BALB/c mice:

Uemura K, Yamamoto S, Kurihara T, Okamoto T,

Development of an animal infection model for PRV.

Suzuki R, Yoshii K, Kurosu T, Igarashi M, Aoki H,

PLoS Negl Trop Dis 11(12):e0006076, 2017

Sakoda Y, Matsuura Y. Host-derived apolipoproteins

4) Ejiri H, Lim CK, Isawa H, Yamaguchi Y, Fujita R,

play comparable roles with viral secretory proteins

Takayama-Ito M, Kuwata R, Kobayashi D, Horiya M,

Erns and NS1 in the infectious particle formation of

Posadas-Herrera G, Iizuka-Shiota I, Kakiuchi S,

Flaviviridae. PLoS Pathog 13(6):e1006475, 2017

Katayama Y, Hayashi T, Sasaki T, Kobayashi M,9) Fukushi S, Fukuma A, Kurosu T, Watanabe S,

Morikawa S, Maeda K, Mizutani T, Kaku K, Saijo M,

Shimojima M, Shirato K, Iwata-Yoshikawa N, Nagata

Sawabe K. Isolation and characterization of Kabuto

N, Ohnishi K, Ato M, Melaku SK, Sentsui H, Saijo M.

Mountain virus, a new tick-borne phlebovirus from

Characterization of novel monoclonal antibodies

Haemaphysalis flava ticks in Japan. Virus Res

against the MERS-coronavirus spike protein and their

244:252-261, 2017

application in species-independent antibody detection5) Ejiri H, Lim CK, Isawa H, Fujita R, Murota K, Sato T,
Kobayashi D, Kan M, Hattori M, Kimura T,
Yamaguchi

Y,

Takayama-Ito

M,

Horiyaby competitive ELISA. J Virol Methods 251:22-29,
2017

M,

10) Gaowa, Wulantuya, Yin X, Cao M, Guo S, Ding C,

Posadas-Herrera G, Minami S, Kuwata R, Shimoda H,

Kawabata H, Ando S, Su H, Shimada M, Takamoto N,

Maeda K, Katayama Y, Mizutani T, Saijo M, Kaku K,

Shimamura Y, Masuda S, Ohashi N. First case of

Shinomiya H, Sawabe K. Characterization of a novel

human Anaplasma phagocytophilum infection in Inner

thogotovirus isolated from Amblyomma testudinarium

Mongolia. China. Jpn J Infect Dis 71:155-157, 2018

ticks in Ehime, Japan: A significant phylogenetic

11) Gokuden M, Fukushi S, Saijo M, Nakadouzono F,

relationship to Bourbon virus. Virus Res 249:57-65,

Iwamoto Y, Yamamoto M, Hozumi N, Nakayama K,

2018

Ishitani K, Nishi N, Ootsubo M. Low seroprevalence

of severe fever with thrombocytopenia syndrome virus

detection of chikungunya virus antigen in India, aantibodies in individuals living in an endemic area indengue-endemic country. Virol J 15(1):84, 2018

Japan. Jpn J Infect Dis 71(3):225-228, 201819) Kakiuchi S, Tsuji M, Nishimura H, Yoshikawa T,12) Hashimoto T, Kutsuna S, Maeki T, Tajima S, Takaya S,

Wang L, Takayama-Ito M, Kinoshita H, Lim CK, Fujii

Katanami Y, Yamamoto K, Takeshita N, Hayakawa K,

H, Yamada S, Harada S, Oka A, Mizuguchi M,

Kato Y, Kanagawa S, Ohmagari N. A case of dengue

Taniguchi S, Saijo M. The association of thefever imported from Burkina Faso to Japan in Octoberemergence of acyclovir-resistant herpes simplex virus

2016. Jpn J Infect Dis 70:675-677, 2017

1 with the prognosis in hematopoietic stem cell13) Hashimoto T, Kutsuna S, Tajima S, Nakayama E,
Maeki T, Taniguchi S, Lim CK, Katanami Y,

transplantation patients. J Infect Dis 215(6):865-873,
2017

Takeshita N, Hayakawa K, Kato Y, Ohmagari N.

20) Kakiuchi S, Tsuji M, Nishimura H, Wang L,

Importation of Zika virus from Vietnam to Japan,

Takayama-Ito M, Kinoshita H, Lim CK, Taniguchi S,

November 2016. Emerg Infect Dis 23(7):1223-1225,

Oka A, Mizuguchi M, Saijo M. Human parainfluenza

2017

virus type 3 infections in hematopoietic stem cell14) Hishiki T, Kato F, Tajima S, Toume K, Umezaki M,

transplantation patients: The mode of nosocomial

Takasaki T, Miura T. Hirsutine, an indole alkaliid of

infections and the prognosis. Jpn J Infect Dis

Uncaria rhynchophylla, inhibits late step in dengue

71(2):109-115, 2018virus lifecycle. Front Microbiol 8:1674, 201721) Kamiyama N, Soma R, Hidano S, Watanabe K,15) Iizuka I, Ami Y, Suzaki Y, Nagata N, Fukushi S, Ogata

Umekita H, Fukuda C, Noguchi K, Gendo Y, Ozaki T,

M, Morikawa S, Hasegawa H, Mizuguchi M, Kurane I,

Sonoda A, Sachi N, Runtuwene LR, Miura Y,

Saijo M. A single vaccination of nonhuman primates

Matsubara E, Tajima S, Takasaki T, Eshita Y,

with highly attenuated smallpox vaccine, LC16m8,

Kobayashi T. Ribavirin inhibits ZIka virus (ZIKV)

provides long-term protection against monkeypox. Jpn

replication in vitro and suppresses Viremia in

J Infect Dis 70(4):408-415, 2017

ZIKV-infected STAT1-deficient mice. Antiviral Res16) Ikeda J, Matsushima A, Ishii W, Goto T, Takahashi K,

146:1-11, 2017

Nakamichi K, Saijo M, Sekijima Y, Ikeda SI. Brain

22) Kaneko M, Shikata, Matsukage S, Maruta M,

biopsy is more reliable than the DNA test for JC virus

Shinomiya H, Suzuki T, Hasegawa H, Shimojima M,

in derebrospinal fluid for the diagnosis of progressive

Saijo

multifocal

thrombocytopenia

leukoencephalopathy.

InternMed

56(10):1231-1234, 2017

Nakamichi K, Saijo M, Toyohara J, Ishii K. PET
Imaging of 18F-FDG, 11C-methionine, 11C-flumazenil,11

C-4DSTinA

patient

withsyndrome

severe
and

fever

with

hemophagocytic

lymphohistiocytosis-associated involvement of the17) Ishibashi K, Miura Y, Matsumura K, Kanemasa Y,

and

M.

progressive

centralnervoussystem.

J

InfectChemother24(4):292-297, 201823) Kaneko M, Maruta M, Shikata H, Asou K, Shinomiya

multifocal

H, Suzuki T, Hasegawa H, Shimojima M, Saijo M.

leukoencephalopathy. Intern Med 56(10):1231-1234,

Unusual presentation of a severely ill patient having

2017

severe fever with thrombocytopenia syndrome: a case18) Jain J, Okabayashi T, Kaur N, Nakayama E, Shioda T,
Gaind R, Kurosu T, Sunil S. Evaluation of an
immunochromatography

rapid

diagnosis

kit

for

report. J Med Case Rep 11(1):27, 201724) Katanami Y, Kutsuna S, Taniguchi S, Tajima S,
Takaya S, Yamamoto K, Takeshita N, Hayakawa K,
Kanagawa S, Kato Y, Ohmagari N. Detection of Zika

virus in a traveller from Vietnam to Japan. J Travel

mild IRIS in MS: A clinicopathologic study. Neurol

Med 24(5), 2017

Neuroimmunol Neuroinflamm 5(1):e415, 201725) Kato F, Ishida Y Kawakami A, Takasaki T, Saijo M,32) Ogawa M, Satoh M, Kataoka M, Ando S, Saijo M.

Miura T, Hishiki T. Evaluation of Macaca radiata as a

Nitric oxide enhanced the growth of an obligated

non-human primate model of Dengue virus infection.

intracellular bacterium Orientia tsutsugamushi in

Sci Rep 8(1):3421, 2018murine macrophages. Microbial Pathog 107:335-340,

26) Kato F, Tajima S, Nakayama E, Kawai Y, Taniguchi S,
Shibasaki K, Taira M, Maeki T, Lim CK, Takasaki T,

201733) Ogawa M, Satoh M, Saijo M, Ando S. Evaluation of a

Saijo M. Characterization of large and small-plaquebroad-ranging

variants

isolateimmunosorbent assay using the lysate of infected cells

ZIKV/Hu/S36/Chiba/2016. Sci Rep 7(1):16160, 2017with five serotypes of Orientia tsutsugamushi, a27) Kutsuna S, Kato Y, Nakayama E, Taniguchi S,

causative agent of scrub typhus. BMC Microbiol

in

the

Zika

virus

clinicalTakasaki T, Yamamoto K, Takeshita N, Hayakawa K,

andconvenient

enzyme-linked

17(1):7, 2017

Kanagawa S, Ohmagari N. A case of consecutive34) Omura N, Yoshikawa T, Fujii H, Shibamura M,

infection with Zika virus and Chikungunya virus in

Inagaki T, Kato H, Egawa K, Harada S, Yamada S,

Bora Bora, French Polynesia. J Infect ChemotherTakeyama H, Saijo M. A novel system for constructing

23(2):114-116, 2017a recombinant highly-attenuated vaccinia virus strain

28) Moi ML, Ami Y, Muhammad Azami NA, Shirai K,(LC16m8) expressing foreign genes and its application

Yoksan S, Suzaki Y, Kitaura K, Lim CK, Saijo M,

for the generation of LC16m8-based vaccines against

Suzuki R, Takasaki T, Kurane I. Marmosets (Callithrix

herpes simplex virus 2. Jpn J Infect Dis 71:229-233,

jacchus) as a non-human primate model for evaluation

2018

of

candidatedengueand35) Ozawa H, Tajima S, Nakayama E, Kato K, Yamashita

maintenance of specific protective immunity against

A, Sekizuka T, Kuroda M, Usuku S. Isolation andchallenges

complete genome sequencing of Zika virus imported

withclinicalvaccines:

isolates.

induction

J

Gen

Virol

98(12):2955-2967, 201729) Murakami S, Takenaka-Uema A, Kobayashi T, Kato K,

from the Dominican Republic to Japan. Jpn J Infect
Dis 71(1):72-74, 2018

Shimojima M, Palmarini M, Horimoto T. Heparan

36) Phanthanawiboon S, Pambudi S, Omokoko MD,

sulfate proteoglycan is an important attachment factor

Hanabara K, A-Nuegoonpipat A, Kamitani W, Ikuta K,

for cell entry of Akabane and Schmallenberg viruses. J

Kurosu T. Construction of a high-yield dengue virus

Virol 91(15). pii: e00503-17, 2017by replacing nonstructural proteins 3-4B without30) Nakayama E, Tajima S, Kotaki A, Shibasaki KI,
Itokawa K, Kato K, Yamashita A, Sekizuka T, Kuroda

increasing virulence. Biochem Biophys Res Commun
495(1):1221-1226, 2018

M, Tomita T, Saijo M, Takasaki T. A summary of the37) Sayama Y, Zamoto-Niikura A, Matsumoto C, Saijo M,

imported cases of Chikungunya fever in Japan from

Ishihara C, Matsubayashi K, Nagai T, Satake M.

2006 to June 2016. J Trop Med 25(1), 2018

Analysis of antigen-antibody cross-reactivity among31) Nishiyama S, Misu T, Shishido-Hara Y, Nakamichi K,

lineages and sublineages of Babesia microti parasites

Saijo M, Takai Y, Takei K, Yamamoto N, Kuroda H,

using

Saito R, Watanabe M, Tominaga T, Nakashima I,

58:1234-1244, 2018

Fujihara K, Aoki M. Fingolimod-associated PML withhumanbabesiosis

specimens.

Transfusion

38) Shigemura T, Nakazawa Y, Yoshikawa T, Fujii H,
Yamada

S,

Saijo

M,

OkuyamaR.

Severeacyclovir-resistant herpes simplex virus 1 infectionthat makes plaques in inoculated cells. J Virol Methods

following cord blood transplantation. Int J Hematol.

244:4-10, 2017201846) Taniguchi S, Maeda K, Horimoto T, Masangkay JS,

39) Suzuki T, Kutsuna S, Taniguchi S, Tajima S, Maeki T,

Puentespina R Jr, Alvarez J, Eres E, Cosico E, Nagata

Kato F, Lim CK, Saijo M, Tsuboi M, Yamamoto K,

N, Egawa K, Singh H, Fukuma A, Yoshikawa T, Tani

Morioka S, Ishikane M, Hayakawa K, Kato Y,

H, Fukushi S, Tsuchiaka S, Omatsu T, Mizutani T,

Ohmagari N. Dengue virus exported from Cote dIvoire

Une Y, Yoshikawa Y, Shimojima M, Saijo M, Kyuwa

toS. First isolation and characterization of pteropine

Japan,

June

2017.

Emerg

InfectDis23(10):1758-1760, 2017

orthoreoviruses in fruit bats in the Philippines. Arch40) Taira M, Ogawa T, Nishijima H, Yamamoto K, Hotta

Virol 162(6):1529-1539, 2017

C, Akita M, Tajima S, Saijo M. The first isolation of47) Tsuboi M, Kutsuna S, Maeki T, Taniguchi S, Tajima S,

Zika virus from a Japanese patient who returned to

Kato F, Lim CK, Saijo M, Takaya S, Katanami Y,

Japan from Fiji in 2016. Jpn J Infect Dis 70(5):586-589,

Kato Y, Ohmagari N. Dengue virus type 2 in travelers

2017

returning to Japan from Sri Lanka, 2017. Emerg infect41) Tajima S, Nakayama E, Kotaki A, Moi ML, Ikeda M,
Yagasaki K, Saito Y, Shibasaki KI, Saijo M, Takasaki
T.

Whole

genomesequencing-based

molecular

Dis 23(11):1931-1933, 201748) Ueno T, Sato N, Kon T, Haga R, Nunomura JI,
Nakamichi K, Saijo M, Tomiyama M. Progressive

epidemiologic analysis of autochthonous dengue virus

multifocal

leukoencephalopathy

associatedwithtype 1 strains circulating in Japan in 2014. Jpn J Infectthymoma with immunodeficiency: a case report andDis 70(1):45-49, 2018

literature review. BMC Neurol 18(1):37, 201842) Takagi Y, Matsui K, Nobori H, Maeda H, Sato A,

49) Yoshikawa T, Fujii H, Okutani A, Shibamura M,

Kurosu T, Orba Y, Sawa H, Hattori K, Higashino K,

Omura N, Egawa K, Kato H, Inagaki T, Harada S,

Numata Y, Yoshida Y. Discovery of novel cyclic

Yamada S, Morikawa S, Saijo M. Construction andpeptide inhibitors of dengue virus NS2B-NS3 proteasecharacterization of bacterial artificial chromosomeswith antiviral activity. Bioorg Med Chem Lett

harboring the full-length genome of a highly attenuated27(15):3586-3590, 2017vaccinia virus LC16m8. PLoS One 13:e0192725, 201843) Takaya S, Kutsuna S, Nakayama E, Taniguchi S,
Tajima S, Katanami Y, Yamamoto K, Takeshita N,
Hayakawa K, Kato Y, Kanagawa S, Ohmagari N.
Chikungunya fever in traveler from Angola to Japan,
2016. Emerg Infect Dis 23(1):156-158, 201744) Takayama-Ito M, Lim CK, Nakamichi K, Kakiuchi S,
Horiya M, Posadas-Herrera G, Kurane I, Saijo M.
Reduction of animal suffering in rabies vaccine
potency testing by introduction of humane endpoints.
Biologicals 46:38-45, 201745) Taniguchi S, Fukuma A, Tani H, Fukushi S, Saijo M,
Shimojima M. A neutralization assay with a severe
fever with thrombocytopenia syndrome virus strain