生物薬学講座神経科学分野
氏名

所属

職名

取得学位

専門分野

主な論文・著作・業績①Zou, K., Maeda, T., Watanabe, A., Liu, J., Liu, S., Oba, R., Satoh, Y. I., Komano, H. & Michikawa, M. (2009) Aβ42-to-Aβ40- and angiotensin-converting
activities in different domains of angiotensin-converting enzyme. J Biol Chem 284, 31914- 31920.
②Tanabe, C., Maeda, T., Zou, K., Liu, J., Liu, S., Nakajima, T., & Komano, H. (2012) The ubiquitin ligase synoviolin up-regulates amyloid β production bytargeting a negative regulator of γ-secretase, Rer1, for degradation. J Biol Chem 287, 44203-44211③Zou, K., Liu, J., Watanabe A., Liu, A., Hiraga, S., Matsumoto, Y., Miura1, Y., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Michikawa, M., Komano, H.
(2013) Aβ43 is the earliest depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE. Am J Pathol 182,2322-2331.
④Liu J., Liu S., Matsumoto Y., Murakami S., Sugakawa Y., Kami A., Tanabe C., Maeda T., Michikawa M., Komano H., Zou K. (2015) Angiotensin type 1areceptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology. Sci Rep 12059, doi:10.1038.
⑤Fujita, Y., Maeda, T., Kamaishi, K., Saito, R., Chiba, K., Shen, X., Zou, K., and Komano, H. (2017) Expression of MEGF10 in cholinergic and glutamatergic
neurons. Neurosci Lett 653, 25-30.
⑥ Maeda T., Fujita Y., Fujimura C., Zou K., Liu,J., Liu,S., Kikuchi,K, Shen X., Nakajima T., Komano H.（2018） An E3 ubiquitin ligase, synoviolin, is involved in駒野宏人

生物薬学講座神経科学分野教授

博士(薬学)

神経科学、生化学

the degradation of homocysteine-inducible endoplasmic reticulum protein. Biol.& Pharm. Bull. 41:915-919.
⑦Shen X., Liu J., Fujita Y., Liu,S., Kikuchi K., Maeda T., Sera K., Michikawa M., Komano K., and Zou, K.（2019）Iron treatment inhibits Aβ42 deposition invivo and reduces Aβ42/ Aβ40 ratio. Biochem. Biophys. Res. Commun. 512:653-658.
⑧Liu,S., Ando F., Fujita Y., Liu J., Maeda T., Shen X., Kikuchi K., Matsumoto A., Yokomori M., Tanabe-Fujimura C., Shimokata H., Michikawa M., Komano H.,and Zou K.(2019)
A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer’sdisease pathology in mice
J. Biol. Chem. 294:9760-9770.
⑨. Kikuchi K., Fujita Y., Shen X., Junjun Liu J., Terakawa T., Nishikata D., Niibori S., Ito T., Ashidate K., Kikuchi T., Kikuchi Y., Maeda T., Zou K. and Komano
H.(2020)
Interaction between angiotensin receptor and β-adrenergic receptor regulates the production of amyloid β-protein. Biol.& Pharm. Bull.43:731-735 (2020)⑩Fujita, Y., Maeda, T., Sato, C., Sato, M., Hatakeyama, H., Ota, Y., Iwabuchi, N., Tatesawa, K., Nomura, A., Zou, K., and Komano, H. Engulfment of toxic生物薬学講座神経科学分野
氏名

所属

職名

取得学位

専門分野

主な論文・著作・業績①Fujita, Y., Nagaosa, K., Shiratsuchi, A., Nakanishi, Y.(2012) Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila. Drug Discov Ther6, 291-297.
②Tung, T.T., Nagaosa, K., Fujita, Y., Kita, A., Mori, H., Okada, R., Nonaka, S., Nakanishi, Y.(2013) Phosphatidylserine recognition and induction of apoptotic cell
clearance by Drosophila engulfment receptor Draper. J Biochem 5,483-491.
③Maeda, T., Inagaki, M., Fujita, Y., Kimoto, T., Tanabe-Fujimura, C., Zou, K., Liu, J., Liu, S., and Komano, H. (2016)

ATP increases the migration of microglia

across the brain endothelial cell monolayer. Biosci Rep, 36, e00318-e00326.
④Maeda, T., Tanabe-Fujimura, C., Fujita, Y., Abe, C., Nanakida, Y., Zou, K., Liu, J., Liu, S., Nakajima, T., and Komano, H.(2016) NAD(P)H quinonoxidoreductase 1 inhibits the proteasomal degradation of homocysteine-induced endoplasmic reticulum protein.

B B R C, 473, 1276-1280.

⑤Fujita, Y., Maeda, T., Kamaishi, K., Saito, R., Chiba, K., Shen, X., Zou, K., and Komano, H. (2017) Expression of MEGF10 in cholinergic and glutamatergic
neurons. Neurosci Lett 653, 25-30.

藤田融

生物薬学講座神経科学分野助教

博士（医学）

生物系薬学、生化学⑥ Maeda T., Fujita Y., Fujimura C., Zou K., Liu,J., Liu,S., Kikuchi,K, Shen X., Nakajima T., Komano H.（2018） An E3ubiquitin ligase, synoviolin, is involved in the degradation of homocysteine-inducible endoplasmic reticulum protein. Biol.& Pharm. Bull. 41:915-919.
⑦Shen X., Liu J., Fujita Y., Liu,S., Kikuchi K., Maeda T., Sera K., Michikawa M., Komano K., and Zou, K.（2019）Iron treatment inhibits Aβ42 deposition invivo and reduces Aβ42/ Aβ40 ratio. Biochem. Biophys. Res. Commun. 512:653-658.
⑧Liu,S., Ando F., Fujita Y., Liu J., Maeda T., Shen X., Kikuchi K., Matsumoto A., Yokomori M., Tanabe-Fujimura C., Shimokata H., Michikawa M., Komano H.,and Zou K.(2019)
A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer’sdisease pathology in mice
J. Biol. Chem. 294:9760-9770.
⑨. Kikuchi K., Fujita Y., Shen X., Junjun Liu J., Terakawa T., Nishikata D., Niibori S., Ito T., Ashidate K., Kikuchi T., Kikuchi Y., Maeda T., Zou K. and Komano
H.(2020)
Interaction between angiotensin receptor and β-adrenergic receptor regulates the production of amyloid β-protein. Biol.& Pharm. Bull.43:731-735 (2020)⑩Fujita, Y., Maeda, T., Sato, C., Sato, M., Hatakeyama, H., Ota, Y., Iwabuchi, N., Tatesawa, K., Nomura, A., Zou, K., and Komano, H. Engulfment of toxic