International Health

Global Health Policy ———————————————————————————————————————————
http://www.ghp.m.u-tokyo.ac.jp

Our mission is to improve population health by enhancing accountability and improving evidencebase of global (both domestic and international) health programmes through the provision of best
possible information and rigorous monitoring and evaluation. The department's members generateknowledge and ideas through their research, strengthen technical and leadership skills through educational programs, and enhance national capacities through collaborative projects, especially in thedeveloping world.
The priority areas of research are:
1. Health outcome research (mortality, morbidity and disability, health services,cost-effectiveness of interventions, disease modeling, resource flows, andimpact evaluation, including tracking the progress towards the Millennium
Development Goals and contribution to the Global Burden of Disease study);
2. Health system performance assessment, including the analysis of health system inputs (evidence on financing and human resources), outputs (service
delivery, effective coverage), and impact (health status); and3. Health and foreign policy (e.g. global health architecture and governance, G8and global health, donor commitments).
Finally, the fundamental role of the Department is to produce the next generations of leaders in global health.

Community and Global Health ———————————————————————————————————
http://www.ich.m.u-tokyo.ac.jp/

Our Department aims at bringing together clinical, public health and social science research to address
following aspects of international health. We also conduct international cooperation activities with theU.N., JICA, local government and NGOs in developing countries. Our educational activities provide
practical trainings for students, who are enthusiastic about contributing to research in international
health and to international cooperation.

• Health promotion in developing countries• Health and human rights• Conflicts and health• School health• Infectious diseases (HIV/AIDS, TB, Malaria etc.)• Nutrition• Health policy and its impact on health of community people• Global health workforce policy50

Human Genetics ——————————————————————————————————————————————
http://www.humgenet.m.u-tokyo.ac.jp/

Department of Human Genetics is broadly interested in the human genome diversity, especially in
the Asian populations. Specifically, we are using genomic research tools including SNP andmicrosatellite analyses, as well as gene expression profiling, to better understand the genetic background of a variety of complex diseases, especially bone and joint diseases, infectious diseases andsleep disorders.

• Theoretical and experimental analyses on the genetics of complex diseases• Development of statistical approaches for susceptibility gene mapping in complex diseases• Comprehensive genetics of bone and joint diseases• Host susceptibility factors to infectious diseases• Molecular mechanisms of sleep disorders• Development of new methodologies for genomic polymorphism and gene
expression analyses• Analysis on the genome diversity of Asia-Pacific populations• Development of methodologies for the analysis of protein interactions
Tools for genomic analyses

Developmental Medical Sciences —————————————————————————————————
Founded in 1966 as the Department of Maternal and Child Health, this department has devoted
itself to the research and education on the maintenance and promotion of mothers' and children's
health, including studies of infectious diseases, nutritional disorders and congenital anomalies. At
present, the main research activities are experimental and epidemiological studies on the etiology(genetic and environmental factors), pathogenesis, prevention and treatment of various childhood
brain disorders (congenital and acquired) that cause mental and motor disabilities and epilepsy,
from the viewpoint of international health science and developmental neuroscience.

• Studies on developmental brain disorders• Abnormal neuronal differentiation and size control (tuberous sclerosis)• Neuronal migration disorders (lissencephaly, polymicrogyria)• Perinatal brain injury (periventricular leukomalacia)• Postnatal brain injury (acute encephalopathy)• Inherited metabolic disorders (peroxisomal and mitochondrial disorders)• Molecular epidemiology of infectious diseases (diarrheal viruses)• Field studies of maternal and child health (malnutrition, obesity)

Time- and space-specific expression of doublecortin,a protein regulating neuronal migration

Human Ecology ——————————————————————————————————————————————
http://www.humeco.m.u-tokyo.ac.jp/

Ecological understanding of health and survival of contemporary human populations through theanalyses of nutritional, demographic, and environmental aspects of each population is our primarygoal. Both fieldworks on various Asia-Oceania populations as well as experimental studies dealing
with nutrition and environmental chemicals are conducted, which would serves as the basis in challenging the International Health issues.

• Mechanistic analyses of the effect of subsistence transitions on the healthand environment in rural and urban communities in developing countries• Application of GPS, GIS, and remote sensing to health ecology and inter-national health• Exposure-effects evaluation of chemical pollution of watershed in rural
Indonesian children• Nutritional ecology, subsistence ecology, medical anthropology and biologicaldemography in Asia-Oceania populations• Development effects of perinatal exposures to heavy metals, pesticides, orendocrine disrupting chemicals• Modulating effects of nutrients and nutritional status on environmental
hazardous chemicals• Sustainable society and health

At a school in a survey area, West Java, Indonesia

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Biomedical Chemistry ——————————————————————————————————————————
The aim of our department is to contribute to the overall global health and welfare through basicresearch. Our current interests are: the energy metabolism of humans, parasites, and bacteria; andRNA and RNA-binding proteins.

• Human succinate dehydrogenase complex and mitochondrial myopathy• Ascaris suum and Caenorhabditis elegans• Molecular mechanism of adaptation to low oxygen tension• Mitochondrial quinol-fumarate reductase• C. elegans as a model system of parasitic nematodes and ageing• Malaria and Trypanosome: characterization of mitochondria as a targetfor chemotherapy• Escherichia coli and Mycobacterium: respiratory enzymes and regulation of energy supply• RNA and RNA-binding proteins• Mitochondriral translation system• RNA biogenesis of Eukarya and Archaea

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Free-living nematode Caenorhabditis elegans expressing a
recombinant green fluorescent protein inside the bodyunder the control of the promoter of the iron-sulfur subunit(Ip) gene of succinate-ubiquinone reductase (complex II)