18. AIDS Research Center

Mori H, Irahara Y, Yamada Y, Nomura W, Matsushita,S, Yoshimura K, Tamamura H: A minimally cytotoxic

1)

Yamamoto H, Matano T: Patterns of HIV/SIV

CD4 mimic as an HIV entry inhibitor. Bioorg Medprevention

Chem Lett 26: 397-400, 2016.

andcontrolbypassive

antibody
10)

immunization. Front Microbiol 7: 1739, 2016.
2)

Yamamoto H, Iseda S, Nakane T, Nomura T, Takahashi

S,N, Seki S, Nakamura M, Ishii H, Matano T:

maraviroc-resistant mutation M434I in the C4 region ofAugmentation of anti-simian immunodeficiency virus

HIV-1 gp120 on sensitivity to antibody-mediatedactivity in CD8+ cells by neutralizing but notneutralization. Jpn. J Infect Dis 69: 236-243, 2016.

nonneutralizing antibodies in the acute phase. AIDS3)of

Tsunetsugu-Yokota Y, Kobayahi-Ishihara M, Wada Y,

human

Homeostatically Maintained Resting Naive CD4+ T

immunodeficiency virus-specific naïve CD4(+) T cells

Cells Resist Latent HIV Reactivation. Front Microbiol

may facilitate persistent viral replication and chronic

7: 1944, 2016.

depletion

leadingtoofacquired

immunodeficiency12)

Ishizaka A, Sato H, Nakamura H, Koga M, Kikuchi T,syndrome. Med Hypotheses 94: 81-85, 2016.

Hosoya N, Koibuchi T, Nomoto A, Kawana-Tachikawa

Ishii H, Matsuoka S, Nomura T, Nakamura M, Shiino T,A, Mizutani T: Short intracellular HIV-1 transcripts as

Sato Y, Iwata-Yoshikawa N, Hasegawa H, Mizuta K,

biomarkers of residual immune activation in patients

Sakawaki H, Miura T, Koyanagi Y, Naruse TK, Kimuraon antiretroviral therapy. J Virol 90: 5665-5676, 2016.

Gag-specificcentral-memoryand13)

higherTakeda S, Takizawa M, Miyauchi K, Urano E, Fujino
M,

MurakamiT,

Murakami

T,KomanoJ:

Env-specific effector-memory CD8+ T-cell frequencies

Conformational properties of the third variable loop ofin a macaque AIDS model. Sci Rep 6: 30153, 2016.

HIV-1AD8 envelope glycoprotein in the liganded

Iseda S, Takahashi N, Poplimont H, Nomura T, Seki S,conditions. Biochem Biophys Res Commun 475(1):Nakane T, Nakamura M, Shi S, Ishii H, Furukawa S,113-118, 2016.

Biphasic

CD8+T-celldefensein14)Hikichi Y, Yokoyama M, Takemura T, Fujino M,

simianKumakura S, Maeda Y, Yamamoto N, Sato H, Matano

immunodeficiency virus control by acute-phase passive

T, Murakami T: Increased HIV-1 sensitivity toneutralizing antibody immunization. J Virol 90:

neutralizing antibodies by mutations in the Env

6276-6290, 2016.

V3-coding region for resistance to CXCR4 antagonists.

Seki S, Matano T: Development of a Sendai virus

J Gen Virol 97(9): 2427-2440, 2016.

vector-based AIDS vaccine inducing T cell responses.

15)

Sakai K, Ami Y, Suzaki Y, Matano T: First complete

Expert Rev. Vaccines 15: 119-127, 2016.

genome sequence of a simian foamy virus isolate from

Mitsuki YY, Yamamoto T, Mizukoshi F, Momota M,a cynomolgus macaque. Genome Announc 4(6):Terahara

e01332-16, 2016.

K,

YoshimuraK,

HaradaS,

Tsunetsugu-Yokota Y: A novel dual luciferase assay for9)

ImpactRecursion-based

H:8)

K:

Tokunaga K, Yamagishi M, Martinez JP, Meyerhans A:

Harada S, Naruse TK, Kimura A, Matano T, Yamamoto7)

Yoshimura

Tsukamoto T, Yamamoto H, Okada S, Matano T:lower

6)

S,Terahara K, Takeyama H, Kawana-Tachikawa A,A, Matano T: Association of lymph-node antigens with5)

11)

Matsushita

30: 2391-2394, 2016.

viraemia

4)

Boonchawalit S, Harada S, Shirai N, Gatanaga H, Oka

16)

Nyombayire J, Anzala O, Gazzard B, Karita E, Bergin

the simultaneous monitoring of HIV infection and cellP, Hayes P, Kopycinski J, Omosa-Manyonyi G,viability. J Virol Methods 231: 25-33, 2016.

Jackson A, Bizimana J, Farah B, Sayeed E, Parks CL,Ohashi N, Harada S, Mizuguchi T, Irahara Y, Yamada,Inoue M, Hironaka T, Hara H, Shu T, Matano T, Dally

Y, Kotani M, Nomura W, Matsushita S, Yoshimura K,L, Barin B, Park H, Gilmour J, Lombardo A, Excler

Tamamura H: Small-molecule CD4 mimics containing

J-L, Fast P, Laufer DS, Cox JH, the S001 Study Team:mono-cyclohexyl moieties as HIV entry inhibitors.

First-in-humanevaluation

Chem Med Chem 11: 940-946, 2016.

immunogenicityofMizuguchi T, Harada S, Miura T, Ohashi N, Narumi T,

replication-competent Sendai virus-vectored HIV type 1

anof

the

intranasallysafetyandadministered17)

Gag vaccine: induction of potent T-cell or antibody

dysfunction for pathogenesis of cortical degeneration

responses in prime-boost regimens. J Infect Dis 215:

in95-104, 2017.

Neuropathology. 37: 25-34, 2017.

Yoshimura K: Current status of HIV/AIDS in the ART
era. J Infect Chemother 23: 12-16, 2017.

18)

Miyazaki N, Sugiura W, Gatanaga H, Watanabe D,
Yamamoto Y, Yokomaku Y, Yoshimura K, Matsushita
S;

Japaneseantiretroviralprevalence

HIV-MDR
coverageinJapan:StudyandanGroup:

viral

excellentHighsuppression
profilefor

downstream HIV care spectrum. Jpn J Infect Dis 70:158-160, 2017.
19)

Harada S, Yoshimura K: Driving HIV-1 into a
Vulnerable Corner by Taking Advantage of Viral
Adaptation and Evolution. Front Microbiol 8: 390,
2017.

20)

Kamori D, Hasan Z, Ohashi J, Kawana-Tachikawa A,
Gatanaga H, Oka S, Ueno T: Identification of two
uniquenaturallyoccurringVprsequencepolymorphisms associated with clinical parameters in
HIV-1 chronic infection. J Med Virol 89: 123-129,
2017.
21)

Mizuguchi T, Ohashi N, Matsumoto D, Hashimoto C,Nomura W, Yamamoto N, Murakami T, Tamamura H:
Development of anti-HIV peptides based on a viralcapsidprotein.

Biopolymers:PeptideScience108:e22920, 2017.
22)

Fujino M, Sato H, Okamura T, Uda A, Takeda S,
Ahmed N, Shichino S, Shiino T, Saito Y, Watanabe S,
Sugimoto C, Kuroda MJ, Ato M, Nagai Y, Izumo S,
Matsushima K, Miyazawa M, Ansari AA, Villinger F,Mori K: Simian Immunodeficiency Virus Targeting ofCXCR3+ CD4+ T Cells in Secondary Lymphoid Organs
Is Associated with Robust CXCL10 Expression in
Monocyte/Macrophage Subsets. J Virol 91: e00439-17,2017.

23)

Wang J, Zhang Y, Xu Q, Qiu J, Zheng H, Ye X, Xue Y,Yin Y, Zhang Z, Liu Y, Hao Y, Wei Q, Wang W, Mori K,Izumo S, Kubota R, Shao Y, Xing HQ: Menin mediates
Tat-induced neuronal apoptosis in brain frontal cortexof SIV-infected macaques and in Tat-treated cells.
Oncotarget 8:18082-18094, 2017.

24)

Xing HQ, Zhang Y, Izumo K, Arishima S, Kubota R,Xu Q, Mori K, Izumo S: Decrease of aquaporin-4 andexcitatory amino acid transporter-2 indicate astrocyte

HIV-associatedneurocognitive

disorders.