1. Department of Virology I

D， Horiya M， Posadas-Herrera G， Iizuka-Shiota
I， Kakiuchi S， Katayama Y， Hayashi T， Sasaki

1) Azami NAM，Moi ML， Ami Y， Suzaki Y， Lim

T， Kobayashi M， Morikawa S， Maeda K，CK, Taniguchi S, Saijo M, Takasaki T, Kurane I．

Mizutani T， Kaku K， Saijo M， Sawabe K．

Genotype-specific and cross-reactive neutralizing

Isolation and characterization of Kabuto Mountainantibodies induced by dengue virus infection:

virus,

detection of antibodies with different levels ofHaemaphysalis flava ticks in Japan ． Virus Res

neutralizing

244:252-261, 2018 (*These authors contributed

activities

againsthomologous

andheterologous genotypes of dengue virus type 2 incommon marmosets (Callithrix jacchus) ． Virol J
15(1):51, 2018anewtick-borne

phlebovirus

fromequally to this work as first authors.)
6) Fujii H， Kakiuchi S， Tsuji M， Nishimura H，
Yoshikawa T， Yamada S， Omura N， Inagaki T，

2) Bui TT, Moi ML, Nabeshima T, Takemura T,

Shibamura M， Harada S， Taniguchi S， Saijo M．

Nguyen TT, Nguyen LN, Pham HTT, Nguyen TTT,

Application of next-generation sequencing to detect

Manh DH, Dumre SP, Mizukami S, Hirayama K,

acyclovir-resistant herpes simplex virus 1 variants at

Tajima S, Le MTQ, Aoyagi K, Hasebe F, Morita K．

low frequency in thymidine kinase gene of the

A single amino acid substitution in the NS4B protein

isolates recovered from patients with hematopoietic

of Dengue virus confers enhanced virus growth andstem

fitness in human cells in vitro through IFN-dependent

251:123-128，2018

host response．J Gen Virol 99(8):1044-1057, 2018

celltransplantation:

J

Virol

Methods

7) Fujii H， Harada S， Yoshikawa T， Yamada S，

3) Demetria C, Smith I, Tan T, Villarico D, Simon EM,

Omura N， Shibamura M， Inagaki T， Kato H，Centeno R, Tachedjian M, Taniguchi S, Shimojima M,

Fukushi S， Saijo M．Differences in the likelihood of

MirandaMMR,

acyclovir resistance-associated mutations in the

Capistrano R, Tandoc A 3rd, Marsh G, Eagles D,

thymidine kinase genes of herpes simplex virus 1 andCruz R, Fukushi S ． Reemergence of Reston

varicella-zoster virus．Antimicrob Agents Chemotherebolavirus in cynomolgus monkeys, the Philippines,

63(5):pii:

2015． Emerg Infect Dis 24(7):1285-1291, 20181128/AAC.00017-19，posted online 11 March 2019)

NLJ,

MirandaME,

Rondina

e00017-19,

2019

(doi:

10

．

4) Ejiri H*, Lim CK*, Isawa H, Fujita R, Murota K,

8) Fujita R， Kato F， Kobayashi D， Murota K，Sato T, Kobayashi D, Kan M, Hattori M, Kimura T,

Takasaki T， Tajima S， Lim CK， Saijo M， Isawa

Yamaguchi

H ， Sawabe K ． Persistent viruses in mosquito

Y,

Takayama-Ito

M,

HoriyaM,

Posadas-Herrera G, Minami S, Kuwata R, Shimoda H,

culturedMaeda K, Katayama Y, Mizutani T, Saijo M, Kaku K,

flaviviruses．Heliyon 4(8):e00736，2018

Shinomiya H, Sawabe K．Characterization of a novel
thogotovirus

isolated

from

cell

line

suppress

multiplicationof9) Gaowa， Wulantuya， Yin X， Guo S， Ding C，Amblyomma

Cao M， Kawabata H， Sato K， Ando S， Fujita

testudinarium ticks in Ehime, Japan: A significant

H， Kawamori F， Su H， Shimada M， Shimamura

phylogenetic relationship to Bourbon virus．Virus Res

Y， Masuda S， Ohashi N．Spotted fever group249:57-65, 2018 (* These authors contributed equally

Rickettsia in Inner Mongolia，China，2015-2016．

to this work as first authors.)

Emerg Infect Dis 24(11):2105-2107，2018

5) Ejiri H*， Lim CK*， Isawa H， Yamaguchi Y，10) Gokuden M， Fukushi S， Saijo M， Nakadouzono

Fujita R， Takayama-Ito M， Kuwata R， Kobayashi

F， Iwamoto Y， Yamamoto M， Hozumi N，

Nakayama K， Ishitani K， Nishi N， Ootsubo M．
Low

seroprevalenceofseverefever

J 15:84, 2018

with17) Kakiuchi S， Tsuji M， Nishimura H， Wang L，thrombocytopenia syndrome virus antibodies in

Takayama-Ito M ， Kinoshita H ， Lim CK ，

individuals living in an endemic area in Japan．Jpn J

Taniguchi S， Oka A， Mizuguchi M， Saijo M．

Infect Dis 71(3):225-228，2018

Human parainfluenza virus type 3 infections in11) Hidaka Y， Lim CK， Takayama-Ito M， Park CH，hematopoietic stem cell transplantation patients: The

Kimitsuki K， Shiwa N， Inoue KI， Itou T．

mode of nosocomial infections and the prognosis．

Segmentation of the rabies virus genome．Virus Res

Jpn J Infect Dis 71(2):109-115, 2018

252:68-75，201818) Kato F， Ishida Y， Kawakami A， Takasaki T，12) Hirosaki H， Maeda Y， Shimojima M， Maeda K，

Saijo M， Miura T， Hishiki T． Evaluation of

Iwata H， Takeyoshi M．Effects of soluble tumor

Macaca radiata as a non-human primate model ofnecrosis factor (TNF) on antibody-dependent cellular

Dengue virus infection． Sci Rep 8(1):3421， 2018

cytotoxicity of therapeutic anti-TNF-α antibody ．

19) Kawamori F， Shimazu Y， Sato H， Monma N，Immunol Invest 20:1-10，2018

Ikegaya A， Yamamoto S， Fujita H， Morita H，13) Hishiki T， Kato F， Nio Y， Watanabe S， Wen Tan

Tamaki Y， Su H， Shimada M， Takamoto N，NW， Yamane D， Miyazaki Y， Lin CC， Suzuki

Shimamura Y， Masuda S， Ando S， Ohashi N．

R，Tajima S，Lim CK，Saijo M，Hijikata M，

Evaluation of diagnostic assay for Rickettsioses using

Vasudevan

duplex real-time PCR in multiple laboratories indesaturase-1

SG ， Takasakiisrequired

T ． Stearoyl-CoA
forflavivirusRNAreplication．Antiviral Res 165:42-46，2019Japan． Jpn J Infect Dis 71(4):267-273，201820) Kimura T， Fukuma A，Shimojima M， Yamashita

14) Inagaki T，Satoh M，Fujii H，Yamada S，Shibamura

Y， Mizota F， Yamashita M， Otsuka Y， Kan M，M，Yoshikawa T，Harada S，Takeyama H，Saijo M．

Fukushi S， Tani H， Taniguchi S， Ogata M，Acyclovir sensitivity and neurovirulence of herpes

Kurosu T， Morikawa S， Saijo M， Shinomiya H．

simplex virus type 1 with amino acid substitutions in

Seroprevalence

the viral thymidine kinase gene, which were detected

thrombocytopenia syndrome (SFTS) virus antibodies

in the patients with intractable herpes simplex

in humans and animals in Ehime prefecture, Japan, an

encephalitis previously reported．Jpn J Infect Dis

endemic region of SFTS ． J Infect Chemother71(5):343-349，201824(10):802-806，2018

ofsevere

fever

with

15) Ishii J， Shishido-Hara Y， Kawamoto M， Fujiwara21) Kinoshita H，Nakamichi K，Lim CK，Takayama-Ito

S， Imai Y， Nakamichi K， Kohara N．A punctate

M ， Wang L ， Iizuka I ， Kurane I ， Saijo M ．

magnetic resonance imaging pattern in a patient with

A loop-mediated isothermal amplification assay forsystemic lupus erythematosus is an early sign ofthe detection and quantification of JC polyomavirus

progressiveAin cerebrospinal fluid: a diagnostic and clinicalMedmanagement tool and technique for progressive

multifocal

clinicopathologicalleukoencephalopathy:

study

．

Intern57(18):2727-2734，201816) Jain J， Okabayashi T， Kaur N， Nakayama E，multifocal leukoencephalopathy． Virol J 15(1):136，
2018

Shioda T ， Gaind R ， Kurosu T ， Sunil S ．

22) Kitagawa Y， Sakai M， Shimojima M， Saijo M，

Evaluation of an immunochromatography rapid

Itoh M， Gotoh B． Nonstructural protein of severe

diagnosis kit for detection of chikungunya virus

fever with thrombocytopenia syndrome phlebovirus

antigen in India、 a dengue-endemic country． Viroltargets STAT2 and not STAT1 to inhibit type Iinterferon-stimulated JAK-STAT signaling. Microbes

Tsubaki K， Satake M． Investigation of antibody to

Infect 20(6):360-368，2018

severe fever with thrombocytopenia syndrome virus23) Kitani S， Yoshida M， Boonlucksanawong O，

in

blood

samples

Panbangred W， Anuegoonpipat A， Kurosu T，

SFTS-endemic

area

in

Ikuta K， Igarashi Y， Nihira T． Cystargamide B，

113(3):297-299，2018a cyclic lipodepsipeptide with protease inhibitory
activity from Streptomyces sp ．

J Antibiot

71:662-666，2018(SFTSV)

donatedJapan ．

Vox

in

a

Sang

29) Matsuyama S， Shirato K， Kawase M， Terada Y，Kawachi K， Fukushi S， Kamitani W． Middle East
respiratory syndrome coronavirus spike protein is not24) Kumagai K， Cherilyn EA， Ando S， Engel JE，activated directly by cellular furin during viral entry

Hanada K． Both the N- and C- terminal regions of

into target cells． J Virol 92; pii: e00683-18， 2018

the Chlamydial inclusion protein D (IncD) are30) Miura T， Makino R， Yamada K， Matsuura M，

required for interaction with the pleckstrin homology

Okumura M， Yamada S， Watanabe S， Inoue N．

domain of the ceramide transport protein CERT．

Differences in the effects of mutations in GP131， a

Biochem Biophys Res Commun 505(4):1070-1076，

guinea pig cytomegalovirus homologue of pentameric

2018

complex component UL130， on macrophage and25) Kyaw AK ， Ngwe Tun MM ， Nabeshima T ，
Buerano CC，Ando T，Inoue S，Hayasaka D，Limepithelial

cellinfection

．

J

Gen

Virol 99(10):1425-1431，2018

CK， Saijo M， Thu HM， Thant KZ， Morita K．

31) Nakayama E，Tajima S，Kotaki A，Shibasaki KI，Japanese Encephalitis- and dengue-associated acute

Itokawa K， Kato K， Yamashita A， Sekizuka T，

encephalitis syndrome cases in Myanmar. Am J Trop

Kuroda M， Tomita T， Saijo M， Takasaki T． A

Med Hyg 100(3):643-646, 2019

summary of the imported cases of Chikungunya fever26) Maeki T， Tajima S， Kyaw AK， Matsumoto F，
Miura K， Yamashita A， Yoshikawa A， Negishi K，in Japan from 2006 to June 2016． J Travel Med
25(1)，2018 (doi: 10．1093/jtm/tax072)

Noguchi Y， Tadokoro K， Abe K， Taruya J， Koh32) Nguyen TTT， Tajima S， Ikeda M， Nguyen TT，J， Ito H， Ikegaya A， Abe F，Wada M，Nishigata

Le THT，Pham TTH，Pham DQ，Le TQM，Maeki

T， Ikeda M， Kato F， Taniguchi S， Nakayama

T， Taniguchi S， Kato F、 Moi ML， Morita K，E， Takasaki T， Morita K， Lim CK， Saijo M．

Lim CK， Saijo M， Hasebe F． Neutralization

Comparison of neutralizing antibody titers against

potency of sera from Vietnamese patients withJapanese encephalitis virus genotype V strain withJapanese encephalitis (JE) against genotypes I and V

those against genotype I and III strains in the sera ofJE viruses． Jpn J Infec Dis 72(2):115-117，2019Japanese encephalitis patients in Japan in 2016． Jpn

33) Nukuzuma S，Nukuzuma C，Kameoka M，Sugiura S，

J Infect Dis 71(5):360-364，2018

Nakamichi K，Tasaki T， Hidaka K，Takegami T．

27) Matsui T， Kinoshita N， Maeki T， Kutsuna S，Establishment of COS-JC cells persistently producing

Nakamura K， Nakamoto T， Ishikane M， Tajima

archetype JC polyomavirus ． Microbiol Immunol

S， Kato F， Taniguchi S， Lim CK， Saijo M，

62(8):524-530，2018

Ohmagari N． Dengue virus type 2 infection in a34) Ogawa M， Shirasago Y， Ando S， Shimojima M，traveler returning from Saudi Arabia to Japan． Jpn J

Saijo M ，Fukasawa M ．

Caffeic acid ，aInfec Dis 72(5):340-342, 2019coffee-related organic acid， inhibits infection by28) Matsumoto C，Shinohara N，Furuta RA，Tanishige

severe fever with thrombocytopenia syndrome virus

N， Shimojima M， Matsubayashi K， Nagai T，in vitro． J Infect Chemother 24(8):597-601， 201835) Oh H， Shin J， Lee C， Ochiai M， Nojima K，antigen and its use for serosurveillance in traditional

Lim CK， Raut S， Lisovsky I， Williams S， Yoocattle herds in Zambia． Vector Borne Zoonotic Dis

K， Shin DY， Ato M， Ye Q， Han K， Lee C，8(5):273-277，2018

Lee N， Hong JY， Jung K， Hung PV， Jeong J．

41) Saijo M ． Pathophysiology of severe fever withThe 2nd Meeting of National Control Laboratories

thrombocytopenia syndrome and development offor Vaccines and Biologicals in the Western Pacific．

specific antiviral therapy ． J Infect Chemother

Osong Public Health Res Perspect 9(3) : 133-139,

24(10):773-781，2018

201842) Sayama Y，Zamoto-Niikura A，Matsumoto C，Saijo

36) Omura N， Yoshikawa T， Fujii H， Shibamura M，M，Ishihara C，Matsubayashi K，Nagai T，Satake M.

Inagaki T，Kato H， Egawa K， Harada S， Yamada

Analysis of antigen-antibody cross-reactivity among

S， Takeyama H， Saijo M． A novel system forlineages and sublineages of Babesia microti parasites

constructing

using human babesiosis specimens ． Transfusionarecombinant

highly-attenuatedvaccinia virus strain (LC16m8) expressing foreign

58(5):1234-1244，2018

genes and Its application for the generation of43) Setoh YX，Peng NY，Nakayama E，Amarilla AA，

LC16m8-based vaccines against herpes simplex virus

Prow NA，Suhrbier A，Khromykh AA．Fatal brain

2．Jpn J Infect Dis 71(3):229-233，2018

infection is not a unique characteristic of Brazilian37) Ozawa H， Tajima S， Nakayama E， Kato K，

Zika viruses．Viruses 10(10):E541，2018

Yamashita A， Sekizuka T， Kuroda M， Usuku S．

44) Shigemura T，Nakazawa Y， Yoshikawa T， Fujii H，Isolation and complete genome sequencing of Zika

Yamada S ， Saijo M ， Okuyama R ． Severe

virus imported from the Dominican Republic to Japan．

acyclovir-resistant herpes simplex virus 1 infection

Jpn J Infect Dis 71(1):72-74，2018

following cord blood transplantation． Int J Hematol38) Phanthanawiboon S， Pambudi S， Omokoko MD，

108(3):237-238，2018

Hanabara K， A-Nuegoonpipat A， Kamitani W，45) Shimada M， Takamoto N， Su H， Sasahara H，

Ikuta K， Kurosu T． Construction of a high-yield

Shimamura Y， Ando S， Ohashi N． Predomination

dengue virus by replacing nonstructural proteins 3-4B

shift

without increasing virulence． Biochem Biophys Res

phagocytophilum in infected HL-60， THP-1， NB4，

Commun 495:1221-1226，2018

and RF/6A cell lines． Jpn J Infect Dis 72:73-80，

39) Prow NA， Liu L， Nakayama E， Cooper TH， YanofdifferentP44-expressing

Anaplasma

2019

K， Eldi P， Hazlewood JE， Tang B， Le TT，46) Suda Y， Chamberlain J， Dowall S， Saijo M，Setoh YX， Khromykh AA， Hobson-Peters J，Horimoto T， Hewson R， Shimojima M． The

Diener KR， Howley PM， Hayball JD， Suhrbier

development of a novel diagnostic assay that uses a

A ．

A vaccinia-based single vector constructpseudotyped vesicular stomatitis virus for themulti-pathogen vaccine protects against both Zika

detection of neutralizing activity to Crimean-Congoand chikungunya viruses． Nat Commun 9(1):1230，

haemorrhagic fever virus ．

2018

71(3):205-208，2018

Jpn J Infect Dis40) Saasa N，Kajihara M， Dautu G， Mori-Kajihara A，47) Suzuki T， Okamoto T、 Katoh H， Sugiyama Y，Fukushi S， Sinkala Y， Morikawa S， Mweene A，

Kusakabe S， Tokunaga M、 Hirano J， Miyata Y，Takada A， Yoshimatsu K， Arikawa J． Expression

Fukuhara T， Ikawa M， Satoh T， Yoshio S，of a recombinant nucleocapsid protein of Rift Valley

Suzuki R，Saijo M， Huang DCS， Kanto T，Akira

fever virus in Vero cells as an immunofluorescence

S， Matsuura Y． Infection with flaviviruses requires

BCLXLforcellsurvival ． PLoS

Pathog14(9):e1007299，2018

164(1):225-234，2019
54) Ueno T，Sato N，Kon T，Haga R，Nunomura JI，48) Tadokoro K， Ohta Y， Sato K， Maeki T， Sasaki

Nakamichi K，Saijo M，Tomiyama M．Progressive

R ， Takahashi Y ， Shang J ， Takemoto M ，multifocal

Hishikawa N， Yamashita T， Lim CK， Tajima S，thymoma with immunodeficiency: a case report and

Abe K． A Japanese encephalitis patient presenting

literature review． BMC Neurol 18(1):37，2018

with Parkinsonism with corresponding laterality of55) Yamada S，Shimojima M， Narita R， Tsukamoto Y，magnetic

resonanceanddopamineleukoencephalopathy

associatedwithtransporter

Kato H， Saijo M， Fujita T． RIG-I-Like receptor

imaging findings． Intern Med 57(15):2243-2246,

and toll-Like receptor signaling pathways cause

2018

aberrant

49) Taira M ， Ando S ， Kawabata H ， Fujita H ，production

cytokines/chemokines

in

a

of

inflammatory

severe

fever

with

Kadosaka T，Sato H，Monma N，Ohashi N，Saijo M．

thrombocytopenia syndrome virus infection mouse

Isolation and molecular detection of Ehrlichia

model． J Virol 92(13): e02246-17，2018

species from ticks in western，central，and eastern56) Yamagishi T， Kakimoto K， Doi I， Kawakami C，Japan． Ticks Tick Borne Dis 10: 344-351，2019Shimada T， Matsui T， Oishi K， Saijo M．

50) Takayama-Ito M ， Lim CK ， Yamaguchi Y ，Transmission routes of the virus causing viralPosadas-Herrera G，Kato H，Iizuka I，Islam MT，hemorrhagic fever: Extreme precautions are prudent

Morimoto K ， Saijo M ． Replication-incompetentbut high-quality evidence must be gathered． Infectrabies virus vector harboring glycoprotein gene ofControl Hosp Epidemiol 40(5):608-609，2019

lymphocytic choriomeningitis virus (LCMV) protects
mice from LCMV challenge．

PLoS Negl Trop Dis

12(4):e0006398，2018

57) Yoshikawa T， Fujii H， Okutani A， Shibamura M，Omura N， Egawa K ， Kato H、 Inagaki T，Harada S， Yamada S， Morikawa S， Saijo M．

51) Takeda M， Watanabe S， Katano H， Noguchi K，Construction

andcharacterizationofbacterial

ato Y，Kojima S，Miura T，Majima R，Yamada S，

artificial chromosomes harboring the full-length

Inouegenome of a highly attenuated vaccinia virus

N ． Rolesof

GP33 ， aguineapig

cytomegalovirus-encoded G protein-coupled receptor
homolog， in cellular signaling， viral growth andinflammation in vitro and in vivo ．

PLoS

Pathog 14(12):e1007487，2018
52) Tani H， Komeno T， Fukuma A， Fukushi S，Taniguchi S， Shimojima M， Uda A， Morikawa S，Nakajima N， Furuta Y， Saijo M． Therapeutic
effects of favipiravir against severe fever withthrombocytopenia syndrome virus infection in alethal mouse model: Dose-efficacy studies upon oral
administration． PLoS One 13(10):e0206416，201853) Tohma D，Tajima S，Kato F，Sato H，Kakisaka M，Hishiki T，Kataoka M，Takeyama H，Lim CK，Aida
Y， Saijo M． An estrogen antagonist， cyclofenil，
has

anti-dengue-virus

activity ．

Arch

Virol

LC16m8． PLoS One 13(2):e0192725，2018