The University of Tokyo
Faculty of Medicine
Graduate School of Medicine

PROSPECTUS
2007—2008

Welcome toFaculty of Medicine, Graduate School of Medicine
The University of Tokyo
The Faculty of Medicine and the Graduate School of Medicine focus on education and researchin medicine, nursing, and health sciences, to train future international leaders in these fields.
Having its roots in a vaccination facility established in 1858, our medical school has thelongest history of any in Japan. Each year, the Faculty of Medicine admits about 100 new
students and the School of Health Sciences and Nursing admits about 40. As many as 200
new graduate students enroll each year in Master's and Doctoral programs in the Graduate
School of Medicine, and a new graduate-level School of Public Health was established in
2007.
Entering the 21st century, we are well aware of the challenges posed by rapid developmentsin the life sciences, and by the importance of nursing, public health, health sciences, andenvironmental medicine to Japan's mature population. To meet the need for internationallyactive educators and researchers in this variety of fields, and to stay at the forefront of new
knowledge, we build institutions that are flexible and dynamic. One example is our Center
for Disease Biology and Integrative Medicine, established in 2003, which nurturesdevelopments at the interface of Engineering and Medicine. Our physical infrastructure has
been also strengthened by the recent completion of new university hospital buildings andnew laboratory facilities for biomedical research.
Promoting transdisciplinary approaches to the most modern medical education and research,
we continue pursuing knowledge of the human body in health and disease, diagnosis andtherapeutics, nursing and long-term care, preventive medicine, and health-care services; andwe make the fruits of our efforts available to benefit society.
While extending modern medicine's greatest achievements, our goal is always to foster thetalent needed to take on the challenges posed by the future of medical science and healthcare.

Takao Shimizu
Dean, Faculty of Medicine,
Graduate School of Medicine
The University of Tokyo

HISTORY
1858

May

Practitioners, trained in Dutch (European) medicine in Edo (Tokyo), laid out money to establish the
Shutojo (vaccination center) in Kanda Mitamagaike.

Nov.

Shutojo was destroyed in a fire that had spread from Kanda Aioicho. Shutojo continued its operations at other sites such as the residence of Ito Genboku.

1859

Sep.

Shutojo was reconstructed at Shitaya Izumibashi Dohri.

1860

Oct.

Shutojo became an official medical institution of the Shogunate Government.

1861

Oct.

Shutojo was renamed as Seiyo Igaku-Sho (Institute of Western Medicine) and offered courses ofWestern Medicine in the fields of Education, Autopsy, and Vaccination.

1863

Feb.

Seiyo Igaku-Sho was renamed as Igaku-Sho (Institute of Medicine).

1868

Jul.

Igaku-Sho, affiliated with the Military Hospital which had been moved from Yokohama to Todo residence in Shitaya, was renamed as Daibyoin (the Great Hospital).

1869

Feb.

The Daibyoin was renamed as Igakko-Ken-Byoin (Medical School and Hospital).

Dec.

Igakko-Ken-Byoin was renamed as Daigaku–Toko (University East Building).

1871

Jul.

The Ministry of Education was established and Daigaku-Toko was renamed as Toko (East Building).

1872

Aug.

A School System was established. Toko was renamed as Daiichi-Daigaku-Ku- Igakko (The First
University District Medical School).

1874

May

Daiichi-Daigaku-Ku-Igakko was renamed as Tokyo-Igakko (Tokyo Medical School).

1876

Nov.

Tokyo-Igakko was moved to Hongo.

1877

Apr.

Tokyo Igakko, affiliated with Tokyo-Kaisei School, was renamed as The University of Tokyo. Tokyo
Medical School was renamed as The University of Tokyo Faculty of Medicine.

1886

Mar.

The University of Tokyo was renamed as Imperial University, and The University of Tokyo Faculty of
Medicine was renamed as the Imperial University Medical College. A Graduate School was established.

1897

Jun.

The Imperial University was renamed as Tokyo Imperial University.

1917

Aug.

Eiraku Hospital, affiliated with the Ministry of Education Medical Practice License Examination,
moved to Tokyo Imperial University and was renamed as Koishikawa Hospital affiliated with Tokyo
Imperial University Medical College.

1919

Apr.

A faculty system was established renaming Tokyo Imperial University Medical College as theFaculty of Medicine.

1931
1936

Feb.

The first building of the Faculty of Medicine was constructed.

Jan.

The Brain Research Laboratory was built with funds donated by Mr. Hisasaburo Horikoshi.

Nov.

The second building of the Faculty of Medicine (main building) was constructed.

1947

Oct.

Tokyo Imperial University was renamed as The University of Tokyo.

1950

Apr.

The Institute of Nursing was renamed as The University Nursing School.

1953

Apr.

The School of Health Care and Nursing was founded.

Jul.

The Graduate School was founded, and the Division of Medical Doctor Biological Science wasestablished. The Brain Research Laboratory became the Brain Research Institute of the Faculty of
Medicine.

1956
1958

2

Apr.

The Midwives School was established.

Apr.

The Division of Pharmaceutical Sciences became an independent faculty.

May

The University of Tokyo Faculty of Medicine celebrated its centennial anniversary.

1961
1965

Mar.

The Medical Library was built in commemoration of the centenary.

Apr.

The Institute of Medical Electronics was established.

Apr.

The Research Institute of Logopedics and Pediatrics was established. The School of Health Careand Nursing was reorganized as the School of Health Sciences. The Graduate School of The
University of Tokyo was reorganized and the Division of Medical Doctor Biological Science
became the Faculty of Medicine. The Health science Course was established in the Medical
Science Division.

1966

Sep.

The third building of the Faculty of Medicine was constructed.

1971

Apr.

The Laboratory of Animal Experiments was established.

1973

Mar.

The Animal Center for Biomedical Research was constructed.

1983

Jan.

An annex of the third building of the Faculty of Medicine was constructed.

1985

Sep.

The office of International Academic Affairs was established.

1987

Apr.

Specialized courses were introduced to the Graduate School of Medicine.

1992

Apr.

The School of Health Sciences became the School of Health Science and Nursing. The School ofInternational Health was established in the Medical Science Division.

1995

Jul.

The Radiation Research Institute was established.

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, four divisions, Third
Basic Medicine, Social Medicine, Third and Fourth Clinical Medicine, were replaced with
Pathology, Immunology and Microbiology, Social Medicine, Reproduction and Development, andAging Science and Surgery.

1996

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions, First
Clinical Medicine, Health Science, and International Health, were replaced with Internal Medicine,
Health Science and Nursing, and International Health.

1997

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions, Firstand Second Basic Medicine, and Second Clinical Medicine, were replaced with Molecular Cell
Biology, Functional Biology, Radiology and Biomedical Engineering, and Neuroscience.
As a result of the above-mentioned reorganization, three institutes, the Institute of Brain Research,
the Institute of Medical Electronics, and the Institute of Logopedics and Phoniatrics were maderedundant.

1999

Apr.

The Master course of Medical Science was established in the Graduate School of Medicine. This
course accepts graduates of all faculties except those from Schools of Medicine, Dentistry, andVeterinary Medicine.

2000

Apr.

The International Research Center for Medical Education was established (A shared facility for education and research).

2001

Apr.

The University Branch Hospital was united with the University Hospital.

2003

Apr.

The Center for Disease Biology and Integrative Medicine was established.

2007

Apr.

The School of Public Health was established. This school offers programs for Master of Public
Health.

3

Graduate School of Medicine

Molecular
Cell Biology

Cell Biology and Anatomy･ Cell Biology ･ Structural Biology ･ Structural Cell Biology ･ Cellular Neurobiology
Biochemistry and Molecular Biology･ Molecular Biology ･ Cellular Signaling ･ Physiological Chemistry amd Metabolism

Functional
Biology

Physiology･ Integrative Physiology ･ Cellular and Molecular Physiology ･ Neurophysiology
Pharmacology･ Cellular and Molecular Pharmacology ･ Molecular Neurobiology

Pathology, Immunology
and Microbiology

Pathology･ Human Pathology and Diagnostic Pathology ･ Molecular Pathology
Microbiology･ Microbiology ･ Infection Control and Prevention
Immunology

Radiology and Biomedical
Engineering

Radiology･ Diagnostic Radiology ･ Radiotherapy ･ Nuclear Medicine
Biomedical Engineering･ System Physiology ･ Bioimaging and Biomagnetics ･ Biosystem Construction and Control

Neuroscience

Basic Neuroscience･ Neuropathology ･ Neurochemistry ･ Neurobiology
Speech and Cognitive Sciences･ Speech Science ･ Cognitive Neuroscience ･ Speech Physiology
Clinical Neuroscience･ Neuropsychiatry ･ Neurology ･ Neurosurgery

Social Medicine

Occuaptional, Environmental and Preventive Medicine･ Molecular Preventive Medicine ･ Public Health ･ Radiological HealthForensic Medicine, and Medical Informatics and Economics･ Forensic Medicine ･ Medical Informatics and Economics

Internal Medicine

Medicine I･ Cardiovascular Medicine ･ Vascular Biology ･ Respiratory Medicine ･ Gastroenterology ･ Nephrology
Medicine II･ Endocrinology ･ Nutrition and Metabolism ･ Hematology and Oncology ･ Allergy and Rheumatology･ Infectious Diseases ･ Stress Science and Psychosomatic Medicine
Clinical Laboratory Medicine and Pathology･ Clinical Laboratory Medicine ･ Transfusion Medicine

Reproductive,
Developmental andAging Sciences

Obstetrics and Gynecology･ Reproductive Endocrinology ･ Gynecological Oncology ･ Perinatal Medicine ･ Molecular Cellular Reproductive Medicine
Pediatric Sciences･ Pediatrics ･ Developmental Pediatrics ･ Pediatric Surgery ･ Pediatric Oncology
Aging Sciences･ Geriatrics ･ Aging Research

Surgical Sciences

Surgery･ Thoracic Surgery ･ Cardiovascular Surgery ･ Gastrointestinal Surgery･ Hepato Biliary Pancreatic Surgery ･ Urology ･ Artificial Organ and Transplantation Division･ Surgical Oncology ･ Vascular Surgery ･ Metabolic Care and Endocrine Surgery
Sensory and Motor System Medicine･ Dermatology ･ Plastic and Reconstructive Surgery ･ Oral and maxillofacial Surgery ･ Orthopaedic Surgery･ Ophthalmology ･ Otorhinolaryngology, and Head & Neck Surgery ･ Rehabilitation Medicine
Vital Care Medicine･ Anesthesiology ･ Emergency and Critical Care Medicine

Health Sciences
and Nursing

Health Sciences･ Health Sociology ･ Mental Health ･ Epidemiology and Preventive Health Sciences ･ Biostatistics･ Social Gerontology ･ Health Promotion Sciences ･ Biomedical Ethics
Preventive and Administrative Nursing･ Advanced Clinical Nursing ･ Nursing Administration ･ Family Nursing ･ Community Health Nursing ･ Public Health Nursing
Clinical Nursing･ Adult Nursing ･ Palliative Care Nursing ･ Midwifery and Women's Health･ Psychiatric Nursing ･ Gerontological Nursing ･ Wound Care Management

International HealthInternational Social Medicine･ Health Policy and Planning ･ International Community HealthInternational Biomedical Sciences･ Human Genetics ･ Developmental Medical Sciences ･ Human Ecology ･ Biomedical Chemistry

School of Public Health

Epidemiology and Health Sciences･ Biostatistics ･ Social and Preventive Epidemiology ･ Health Economics and Epidemiology Research･ Health Communication
Behavioral Health Sciences･ Mental Health ･ Health Sociology and Health Education ･ Social Gerontology･ Health Promotion Science ･ Biomedical Ethics
Health Services Sciences･ Health Policy ･ Healthcare Informatics ･ Clinical Information Engineering ･ Forensic Medicine and Medical Law

Center for Disease
Biology andIntegrative Medicine･ Basic Medical Sciences(I)Molecular Biomedicine for Pathogenesis･ Basic Medical Sciences(II)Biophysics ･ Biomedical Materials and Systems･ Clinical Biotechnology ･ Environmental Health Sciences･ Animal Research ･ Radiation Biology ･ Bioinformatics

4

Endowed Department･ Pharmacoepidemiology ･ Integrated Traditional Medicine (Tsumura)･ Corneal Tissue Regeneration (ArBlast Co., Ltd.) ･ Vascular Regeneration (Daiichi Pharmaceutical Co.)･ Bone & Cartilage Regenerative Medicine ･ Cartilage & Bone Regeneration(Fujisoft)･ Clinical Renal Regeneration ･ Developmental and Medical Technology (Sankyo) ･ Metabolome･ Hospital Logistics by Sagawa Express Co., Ltd. ･ Clinical Molecular Epidemiology (Tanabe Seiyaku Co., Ltd.)･ Immunotherapeutics (Medinet) ･ Healthcare Related Informatics (NTT DATA CORPORATION)･ Total Renal Care Medicine ･ Integrated Molecular Science on Metabolic Diseases･ Advanced Clinical Science and Therapeutics ･ Sato Sports Plaza Co., Ltd Kaatsu Training･ Sleep Disorder Research (Alfresa) ･ Translational Research Based on the Clinical Database･ Joint Disease Research ･ Health Care Management and Policy･ Computational Diagnostic Radiology and Preventive Medicine ･ Hospital Environment･ Clinical Motor System Medicine ･ Clinical Drug Evaluation ･ Medical Safety Management(Tokio Marine & Nichido)･ Molecular Cardiovascular Metabolism ･ Healthcare Quality Assessment ･ Coca-Cola Anti-Aging Medicine･ Integrated Imaging Informatics ･ Nutriproteomics ･ Clinical Epidemiology and Systems･ Clinical Trial Data Management ･ Pharmacology and Pharmacokinetics

Research Unit

･ Center for Biomedical Ethics and Law ･ Nano-Bioengineering Education Program･ Health Care and Social Policy Leadership Program

COE Program･ Center for Integrated Brain Medical Science･ Sundy on Deseases Caused by Environment/Genome Interactions

Institution･ International Academic Affairs ･ Medical Library

Faculty of Medicine
School ofMedicine･ Cell Biology and Anatomy ･ Biochemistry and Molecular Biology ･ Physiology ･ Pharmacology･ Pathology ･ Microbiology ･ Immunology ･ Radiology ･ Biomedical Engineering ･ Basic Neuroscience･ Speech and Cognitive Sciences ･ Clinical Neuroscience･ Occupational, Environmental and Preventive Medicine ･ Medical Principles and Medical Ethics･ Forensic Medicine, and Medical Informatics and Economics ･ Medicine I ･ Medicine II･ Clinincal Laboratory Medicine and Pathology ･ Obstetrics and Gynecology ･ Pediatric Science･ Aging Science ･ Sugery ･ Sensory and Motor System Medicine ･ Vital Care Medicine

School of
Health Sciences
and Nursing･ Family Nursing ･ Community Health Nursing ･ Fundamental Nursing ･ Adult Health and Nursing･ Mental Health and Nursing Health Sociology ･ Health Administration ･ Epidemiology and Biostatistics･ Human Ecology ･ Biochemistry and Nutrition ･ Maternal and Child Health

University Hospital
Clinical Division
Intenal Medicine･ General Medicine ･ Cardiovascular Medicine ･ Respiratory Medicine･ Gastroenterology ･ Nephrology and Endocrinology ･ Metabolic Diseases･ Hematology and Oncology ･ Allergy and Rheumatology ･ Infectious Diseases･ Neurology ･ Geriatric Medicine ･ Psychosomatic Medicine
Surgery･ General Surgery ･ Stomach and Esophageal Surgery ･ Colon and Rectal Surgery･ Hepato Biliary Pancreatic Surgery ･ Vascular Surgery ･ Breast and Endocrine Surgery･ Artificial Organ and Transplantation Surgery ･ Cardiovascular Surgery ･ Thoracic Surgery･ Neurosurgery ･ Anesthesiology and Pain Relief Center ･ Urology and Andrology ･ Gynecologic Surgery
Sensory and Motor System Medicine･ Dermatology and Photolaser Medicine ･ Opthalmology and Vision Correction･ Orthopaedic Surgery and Spinal Surgery･ Otorhinolaryngology, and Auditory and Voice Surgery ･ Rehabilitation Medicine･ Plastic, Reconstructive, and Aesthetic Surgery･ Oral-Maxillofacial Surgery, Dentistry and Orthodontics
Pediatrics, Perinatal and Women's Medicine･ Pediatrics ･ Pediatric Surgery ･ Obstetrics and Gynecology
Neuropsychiatry･ NeuropsychiatryRadiology･ Radiology

Central Clinical Facilities･ Clinical Laboratory Center ･ Surgical Center ･ Radiological Center ･ Emergency Services･ Transfusion Medicine ･ Department of Maternal, Fetal, and Neonatal Medicine ･ Rehabilitation Service･ Central Supply Service ･ Department of Medical Engineering ･ Intensive Care Unit ･ Pathology･ Section of Corneal Transplantation ･ Department of Cell Therapy and Transplantation Medicine･ Department of Endoscopy and Endoscopic Surgery ･ Department of Hemodialysis and Apheresis･ Department of Medical Community Network and Discharge Planning ･ Clinical Research Center･ Infection Control and Prevention Service ･ Department of Planning, Information, and Management･ University Hospital Medical Information Network Center ･ Organ Transplantation Service･ Department of Nutrition ･ Labor Safety and Health Management Office･ Department of Child Psychiatry ･ Public Relations ･ Tissue Bank ･ Office of University Corporate Relations･ Center for Epidemiology and Preventive Medicine ･ Division of Tissue Engineering･ Department of Clinical and Genetic Informatics ･ Department of Palliative Medicine･ Department of Clinical Genomics ･ Cooperative Unit of Medicine and Engineering Reserch･ Translational Research Center ･ 22nd Century Medical and Research Center

Pharmaceutical Department
Nursing Department
Administration Office

Center･ Health Service Center ･ The International Research Center for Medical Education

Administrative Division･ General Affairs Office ･ Personnel Office ･ Research Liaison ･ Educational Affairs･ Graduate Student Affairs ･ Buget Office ･ Purchasing Office ･ Finance Office･ Facilities Office ･ Reception Service Medical Library･ Administration Office Medical Library ･ Infomation Service Medical Library5Graduate School of Medicine
Dean

A
G
C
T

P14

Molecular Cell
Biology

Cell Biology and Anatomy*
Department of Cell Biology
Professor
Nobutaka Hirokawa
Associate Professor Yosuke Takei
Department of Structual Biology
Associate Professor Takao Nakata

Takao Shimizu

Microbiology
Department of Microbiology*
Professor
Akio Nomoto
Department of Infection Control and Prevention*
Professor
Kazuhiko Koike

Immunology
Department of Immunology*
Professor
Tadatsugu Taniguchi

Department of Structual Cell Biology
Associate Professor Yoshimitsu Kanai
Department of Cellular Neurobiology
Professor
Shigeo Okabe

Radiology andBiomedical
Engineering

P20

Biochemistry and Molecular Biology

Radiology*

Department of Molecular Biology*
Professor
Hiroto Okayama
Associate Professor Shigeki Jinno

Department of Diagnostic Radiology
Professor
Kuni Ohtomo
Associate Professor Shigeki Aoki

Department of Cellular Signaling*
Professor
Takao Shimizu
Associate Professor Motonao Nakamura
Associate Professor Satoshi Ishii

Department of Radiotherapy
Associate Professor Keiichi Nakagawa

Department of Physiological Chemistry and Metabolism*
Professor
Hiroki Kurihara

Functional Biology

P16

Physiology
Department of Integrative Physiology*
Professor
Yasushi Miyashita
Associate Professor Seiki Konishi

Department of Nuclear Medicine
Associate Professor Toshimitsu Momose

Biomedical Engineering
Department of System Physiology*
Professor
Joji Ando
Department of Bioimaging and Biomagnetics
Department of Biosystem Construction and Control*
Associate Professor Yusuke Abe

Neuroscience

Department of Cellular and Molecular Physiology*
Professor
Kensaku Mori
Department of Neurophysiology*
Professor
Masanobu Kano

Pharmacology
Department of Cellular and Molecular Pharmacology*
Professor
Masamitsu Iino
Department of Molecular Neurobiology*
Professor
Masayoshi Mishina

P22

Basic Neuroscience
Department of Neuropathology*
Professor
Takeshi Iwatsubo
Department of Neurochemistry*
Associate Professor Haruhiko Bito
Department of Neurobiology

Speech and Cognitive Sciences
Department of Speech Science

Pathology,
Immunology andMicrobiology

P18

Department of Cognitive Neuroscience*
Associate Professor Katsuyuki Sakai
Department of Speech Physiology

Pathology

Clinical Neuroscience

Department of Human Pathology and Diagnostic Pathology*
Professor
Masashi Fukayama

Department of Neuropsychiatry*
Associate Professor Nobuo Nakayasu

Associate Professor

Noriyioshi Fukushima

Department of Molecular Pathology*
Professor
Kohei Miyazono
Associate Professor Keiji Miyazawa

6* Introduction to lab included

Department of Neurology*
Professor
Shoji Tsuji
Associate Professor Shin Kwak
Department of Neurosurgery*
Professor
Nobuhito Saito
Associate Professor Nobutaka KawaharaSocial Medicine

P26

Occupational, Environmental andPreventive Medicine
Department of Molecular Preventive Medicine*
Professor
Kouji Matsushima
Associate Professor Sho Ishikawa-Yamawaki
Department of Public Health*Professor
Yasuki Kobayashi
Associate Professor Kazuo Inoue
Department of Radiological HealthForensic Medicine, and Medical Informatics andEconomics
Department of Forensic Medicine*
Professor
Ken-ichi Yoshida
Department of Medical Informatics and Economics*
Professor
Kazuhiko Ohe

Internal Medicine

P28

Reproductive,
Developmental andAging Sciences

P32

Obstrtrics and Gynecology
Department of Reproductive Endocrinology*
Professor
Yuji Taketani
Associate Professor Tomoyuki Fujii
Department of Gynecological Oncology*
Associate Professor Tetsu Yano
Department of Perinatal Medicine*
Associate Professor Shiro Kozuma
Department of Molecular Cellular Reproductive Medicine*
Professor
Osamu Tsutsumi

Pediatric Sciences
Department of Pediatrics*
Professor
Takashi Igarashi
Department of Developmental Pediatrics*
Professor
Takashi Igarashi
Associate Professor Takashi Sekine
Department of Pediatric Surgery*
Professor
Tadashi Iwanaka
Department of Pediatric Oncology*
Professor
Tadashi Iwanaka

Medicine I
Department of Cardiovascular Medicine*
Professor
Ryozo Nagai
Associate Professor

Yasunobu Hirata

Department of Vascular Biology
Department of Respiratory Medicine*
Professor
Takahide Nagase
Department of Gastroenterology*
Professor
Masao Omata

Aging Sciences
Department of Geriartics*
Professor
Yasuyoshi Ouchi (Cardiology)
Associate Professor Masahiro Akishita
Department of Aging Research

Surgical Sciences

Department of Nephrology*

P36

Medicine II

Surgery

Department of Endocrinology*
Professor
Toshiro Fujita

Department of Thoracic Surgery*
Professor
Shinichi Takamoto
Associate Professor Jun Nakajima

Department of Nutrition and Metabolism*
Professor
Takashi Kadowaki
Associate Professor

Kohjiro Ueki

Department of Hematology and Oncology*
Professor
Mineo Kurokawa
Department of Allergy and Rheumatology*
Professor
Kazuhiko Yamamoto
Department of Infectious Diseases*
Professor
Kazuhiko Koike
Department of Stress Science and Psychosomatic Medicine*
Professor
Akira Akabayashi
Associate Professor Hiroaki Kumano

Clinical Laboratory Medicine and Pathology
Department of Clinical Laboratory Medicine*
Professor
Yutaka Yatomi
Associate Professor Hitoshi Ikeda
Department of Transfusion Medicine*
Professor
Koki Takahashi

Department of Cardiovascular Surgery*
Professor
Shinichi Takamoto
Associate Professor Arata Murakami
Department of Gastrointestinal Surgery*
Professor
Michio Kaminishi
Associate Professor Sachiyo Nomura
Department of Hepato Biliary Pancreatic Surgery*
Associate Professor Norihiro Kokudo
Department of Urology*
Professor
Tadaichi Kitamura
Associate Professor Takumi Takeuchi
Kyoichi Tomita
Department of Artificial Organ and Transplantation Division*
Associate Professor Norihiro Kokudo
Associate Professor Yasuhiko Sugawara
Department of Surgical Oncology*
Professor
Hirokazu Nagawa
Department of Vascular Surgery*
Professor
Hirokazu Nagawa
Associate Professor Tetsuro Miyata
Department of Metabolic Care and Endocrine Surgery*
Professor
Michio Kaminishi
Associate Professor Toshihisa Ogawa
Associate Professor Yoshikazu Mimura

7

Sensory and Motor System Medicine

Clinical Nursing

Department of Dermatology*
Professor
Kunihiko Tamaki
Associate Professor Kanako Kikuchi

Department of Adult Nursing*
Professor
Keiko Kazuma

Department of Plastic and Reconstructive Surgery*
Professor
Isao Koshima
Department of Oral and Maxillofacial Surgery*
Professor
Tsuyoshi Takato
Associate Professor Takafumi Susami
Associate Professor Yoshiyuki Yonehara
Department of Orthopaedic Surgery*
Professor
Kozo Nakamura
Associate Professor Yoshio Takatori
Associate Professor Hiroshi Kawaguchi
Department of Ophthalmology*
Professor
Makoto Araie
Associate Professor Satoshi Kato
Associate Professor Yasuhiro Tamaki
Department of Otorhinolaryngology and Head & Neck Surgery*
Professor
Tatsuya Yamasoba (Otology, Neurotology andAudiology)
Department of Rehabilitation Medicine*
Professor
Nobuhiko Haga

Vital Care Medicine
Department of Anesthesiology*
Professor
Yoshitsugu Yamada
Associate Professor Tomoki Nishiyama
Department of Emergency and Critical Care Medicine*
Professor
Naoki Yahagi

Health Sciences
and Nursing

P42

Health Sciences
Department of Health Sociology*
Associate Professor Yoshihiko Yamazaki
Department of Mental Health*Professor
Norito Kawakami
Associate Professor Akihito Shimazu
Department of Epidemiology and Preventive Health Sciences*
Professor
Yasuo Ohashi
Department of Biostatistics*
Associate Professor Yutaka Matsuyama
Department of Social Gerontology*
Professor
Ichiro Kai
Department of Health Promotion Sciences*
Associate Professor Jung Su Lee
Department of Biomedical Ethics*
Professor
Akira Akabayashi

Department of Palliative Care Nursing*
Professor
Keiko Kazuma
Department of Midwifery and Women's Health*Professor
Sachiyo Murashima
Department of Psychiatric Nursing*
Professor
Norito Kawakami
Department of Gerontological Nursing*
Professor
Hiromi Sanada
Department of Wound Care Management*
Professor
Hiromi Sanada

International
HealthP48

International Social Medicine
Department of Health Policy and Planning*
Associate Professor Chushi Kuroiwa
Department of International Community Health*Professor
Masamine Jimba

International Biomedical Sciences
Department of Human Genetics*
Professor
Katsushi Tokunaga
Associate Professor Akihiko Mabuchi
Department of Developmental Medical Sciences*
Professor
Masashi Mizuguchi
Department of Human Ecology*
Professor
Chiho Watanabe
Associate Professor Masahiro Umezaki
Department of Biomedical Chemistry*
Professor
Kiyoshi Kita
Associate Professor Yoh-ichi Watanabe

School of Public
HealthP52

Epidemiology and Health Sciences
Department of Biostatistics
Professor
Yasuo Ohashi
Associate Professor Yutaka Matsuyama
Department of Social and Preventive Epidemiology*
Professor
Satoshi Sasaki
Department of Health Economics and Epidemiology Research*
Professor
Hideki Hashimoto
Associate Professor Takashi Fukuda
Department of Health Communicaton

Preventive and Administrative Nursing
Department of Advanced Clinical Nursing*
Professor
Katsuya Kanda
Department of Nursing Administration*
Professor
Katsuya Kanda
Department of Family Nursing*
Associate Professor Kiyoko Kamibeppu
Department of Community Health Nursing*
Professor
Sachiyo Murashima
Department of Public Health Nursing

8* Introduction to lab included

Professor
Associate Professor

Takahiro Kiuchi
Noriaki Aoki

Behavioral Health Sciences

Department of Cartilage & Bone Regeneration (Fujisoft)
Associate Professor

Kazuto Hoshi

Department of Mental HealthProfessor
Norito Kawakami
Associate Professor Akihito Shimazu

Department of Clinical Renal Regeneration

Department of Health Sociology and Health Education
Associate Professor Yoshihiko Yamazaki

Professor

Department of Social Gerontology
Professor
Ichiro Kai

Associate Professor

Keiichi Hishikawa

Department of Developmental and Medical Technology (Sankyo)
Hiroshi Suzuki

Department of Metabolome
Professor
Associate Professor

Ryo Taguchi
Yoshiya Oda

Hospital Logistics by Sagawa Express Co., Ltd.

Department of Health Promotion Science
Associate Professor Jung Su Lee

Professor

Department of Biomedical Ethics
Professor
Akira Akabayashi

Associate Professor

Health Services Sciences

Healthcare Related Informatics (NTT DATA CORPORATION)

Department of Health Policy
Professor
Yasuki Kobayashi
Associate Professor Kazuo Inoue

Takanari Gotoda

Immunotherapeutics (Medinet)
Associate Professor
Associate Professor

Kazuhiro Kakimi
Shinya Oku

Division of Total Renal Care Medicine
Associate Professor

Akira Ishikawa

Integrated Molecular Science on Metabolic Diseases

Department of Healthcare Informatics
Professor
Kazuhiko Ohe

Associate Professor

Department of Clinical Information Engineering*
Professor
Hiroshi Oyama

Associate Professor

Department of Forensic Medicine and Medical Law
Professor
Ken-ichi Yoshida

Hirohito Kuse

Clinical Molecular Epidemiology (Tanabe Seiyaku Co., Ltd.)

Toshimasa Yamauchi

Department of Advanced Clinical Science and Therapeutics
Masataka Sata

Sato Sports Plaza Co., Ltd Kaatsu Training
Associate Professor

Toshiaki Nakajima

Department of Sleep Disorder Research (Alfresa)
Associate Professor

Takashi Ebisawa

Translational Research Based on the Clinical Database
Associate Professor

Center for Disease
Biology andIntegrative Medicine

P54

Director
Tadatsugu Taniguchi
Division of Basic Medical Sciences(I)Molecular Biomedicine for Pathogenesis*
Professor

Toru Miyazaki

Division of Basic Medical Sciences(II)Biophysics*
Professor

Haruo Kasai

Dobun Hayashi

Department of Joint Disease Research
Associate Professor

Noriko Yoshimura

Health Care Management and Policy
Computational Diagnostic Radiology and Preventive Medicine
Associate Professor
Associate Professor

Naoto Hayashi
Kansei Uno

Hospital Environment
Associate Professor

Yushi Uetera

Clinical Motor System Medicine
Clinical Drug Evalutaion

Division of Biomedical Materials and Systems*

Associate Professor

Professor
Associate Professor

Medical Safety Management (Tokio Marine & Nichido)

Takashi Ushida
Yasuyuki Sakai

Fumihiko Kanai

Division of Clinical Biotechnology*

Professor
Associate Professor

Professor

Molecular Cardiovascular Metabolism

Kazunori Kataoka

Division of Environmental Health Sciences*
Professor
Associate Professor

Chiharu Tohyama
Seiichiroh Ohsako

Associate Professor

Yasushi Kodama
Shoichi Maeda
Katsuyuki AndoThe Department of Healthcare Quality Assessment
Associate Professor

Noboru Motomura

Division of Research Resources and Support
Section of Animal Research*

Coca-Cola Anti-Aging Medicine

Professor

Integrated Imaging Informatics

Akio Nomoto

Professor

Division of Research Resources and Support
Section of Radiation Biology*

Associate Professor

Professor
Associate Professor

Professor

Kiyoshi Miyagawa
Yoshio Hosoi

Division of Research Resources and Support
Section of Bioinformatics*

Satoshi Inoue
Naoki Yoshioka

The Department of Nutriproteomics
Kazumi Yagasaki

Clinical Epidemiology and Systems
Professor
Associate Professor

Tsutomu Yamazaki
Daisuke Koide

Clinical Trial Data Management
Associate Professor

Endowment
Department

Associate Professor

Pharmacoepidemiology
Associate Professor

Takuhiro Yamaguchi

Pharmacology and Pharmacokinetics
Akihiro Hisaka

Research Unit

Kiyoshi Kubota

Department of Integrated Traditional Medicine (Tsumura)
Associate Professor

Tetsuro Okabe

Department of Corneal Tissue Regeneration (ArBlast Co., Ltd.)
Associate Professor

Satoru Yamagami

Center for Biomedical Ethics and Law
Nano-Bioengineering Education Program
Health Care and Social Policy Leadership Program

Department of Vascular Regeneration (Daiichi Pharmaceutical Co.)
Associate Professor

Hiroyuki Koyama

Department of Bone & Cartilage Regenerative Medicine

9Vascular Surgery

COE

Professor
Associate Professor(Center of Excellence)

Program

Hirokazu Nagawa
Tetsuro Miyata

Breast and Endocrine Surgery

Center for Integrated Brain Medical Science
Associate Professor

Professor

Hiroshi Kawasaki

Study on Diseases Caused by Environment/Genome Interactions
Associate Professor
Associate Professor

Makoto Miyagishi
Seiji Ogawa

Professor
Associate Professor

Institution

Office of International Academic Affairs
Kazuhiko Yamamoto

Medical Library
Head

Shinichi Takamoto
Arata Murakami

Thoracic Surgery
Professor
Associate Professor

Head

Michio Kaminishi

Associate Professor Toshihisa Ogawa
Artificial Organ and Transplantation Surgery
Associate Professor Norihiro Kokudo
Cardiovascular Surgery

Shinichi Takamoto
Jun Nakajima

Neurosurgery
Professor

Nobuhito Saito

Associate Professor

Nobutaka Kawahara

Anesthesiology and Pain Relief Center
Professor
Yoshitsugu Yamada

Yasuyoshi Ouchi

Associate Professor

Tomoki Nishiyama

Urology and Andrology
Professor
Associate Professor

Faculty of Medicine
Dean

Takao Shimizu

Gynecologic Surgery
Professor
Associate Professor

P58

University
Hospital

Yuji Taketani

Director

Clinical Division (Department of Intenal Medicine)
General Medicine
Professor
Kazuhiko Yamamoto
Cardiovascular Medicine

Professor
Associate Professor

Ryozo Nagai
Yasunobu Hirata

Respiratory Medicine
Professor

Takahide Nagase

Gastroenterology
Professor

Masao Omata

Nephrology and Endocrinology
Professor

Toshiro Fujita

Metabolic Diseases
Professor

Takashi Kadowaki

Hematology and Oncology
Professor
Mineo Kurokawa
Allergy and Rheumatology
Professor

Kazuhiko Yamamoto

Infectious Diseases
Professor

Akira Akabayashi
Hiroaki Kumano

Stomach and Esophagus Surgery
Michio Kaminishi

Associate Professor Sachiyo Nomura
Colon and Rectal Surgery
Hirokazu Nagawa

Hepatobiliary Pancreatic Surgery
Associate Professor

10

Opthalmology and Vision Collection
Professor
Associate Professor
Associate Professor

Makoto Araie
Yasuhiro Tamaki

Professor
Associate Professor
Associate Professor

Kozo Nakamura
Yoshio Takatori
Hiroshi Kawaguchi

Satoshi Kato
Orthopaedic Surgery and Spinal Surgery

Otorhinolaryngology, and Auditory and Voice Surgery
Professor
Tatsuya Yamasoba
Rehabilitation Medicine
Professor
Nobuhiko Haga
Plastic, Reconstructive and Aesthetic Surgery
Professor

Isao Koshima

Oral-Maxillofacial Surgery Dentistry and Orhtodontics
Professor
Associate Professor
Associate Professor

Tsuyoshi Takato
Takafumi Susami
Yoshiyuki Yonehara

Pediatric Surgery
Professor
Tadashi Iwanaka
Obstetrics and Gynecology

Michio Kaminishi

Professor

Kunihiko Tamaki
Kanako Kikuchi

Yasuyoshi Ouchi
Masahiro Akishita

General Surgery

Professor

Professor
Associate Professor

Pediatrics

Clinical Division (Department of Surgery)
Professor

Dermatology and Photolaser Medicine

Shoji Tsuji
Shin Kwak

Psychomatic Medicine
Professor
Associate Professor

Clinical Division (Department of Sensory and Motor
System Medicine)

Clinical Division (Department of Pediatric, Perinatal
and Women's Medicine)

Geriatric Medicine
Professor
Associate Professor

Osamu Tsutsumi
Tetsu Yano

Kazuhiko Koike

Neurology
Professor
Associate Professor

Tadaichi Kitamura
Takumi Takeuchi
Kyoichi Tomita

Norihiro Kokudo* Introduction to lab included

Professor
Associate Professor

Takashi Igarashi
Takashi Sekine

Professor
Associate Professor

Yuji Taketani
Shiro Kozuma

Associate Professor

Tomoyuki Fujii

Clinical Division (Department of Neuropsychiatry)
Neuropsychiatry
Associate Professor

Nobuo Nakayasu

Cinical Division (Department of Radiology)

P61

CenterRadiology
Professor
Associate Professor
Associate Professor
Associate Professor

Kuni Ohtomo
Keiichi Nakagawa
Shigeki Aoki
Toshimitsu Momose

Health Service Center*
Director
Associate Professor

Central Clinical Facilities
Clinical Laboratory*
Director
Vice Director

Yoshio Uehara
Tsukasa Sasaki
Yasushi Ookubo

The International Research Center for Medical Education*

Yutaka Yatomi (Professor of Medicine, Department of
Director
Clinical Laboratory Medicine)
Professor
Hitoshi Ikeda (Associate Professor of Medicine, Department Associate Professorof Clinical Laboratory Medicine)

Kazuhiko Yamamoto
Kiyoshi Kitamura
Yuko Takeda

Department of Surgical Center*
Professor
Associate Professor

Hiroshi Yasuhara
Yoshikazu Mimura

Department of Radiological Center
Professor and Director

Kuni Ohtomo(Diagnostic Radiology)

Department of Emergency Services
Professor

Naoki Yahagi

Department of Transfusion Medicine and Immunohematology
Professor

Koki Takahashi (Transfusion Medicine)

Department of Maternal, Fetal, and Neonatal
Associate Professor

Shiro Kozuma

Department of Rehabilitation Service
Professor
Nobuhiko Haga
Department of Medical Engineering
Central Supply Service
Associate Professor Yoshikazu Mimura
Department of Intensive Care Unit
Professor

Naoki Yahagi

Department of Intensive Pathology
Professor
Associate Professor

Masashi Fukayama
Noriyioshi Fukushima

Department of Corneal Transplantation
Associate Professor

Shiro Amano

University Hospital Medical Information Network Center*
Professor
Associate Professor

Takahiro Kiuchi
Noriaki Aoki

Department of Cell Therapy and Transplantation Medicine
Associate Professor

Shigeru Chiba

Department of Infection Control and Prevention
Professor

Kazuhiko Koike

Department of Endoscopy and Endoscopic Surgery
Associate Professor

Takao Kawabe

Center for Hemodialysis and Apheresis
Professor

Toshiro Fujita

Clinical Research Center
Professor
Associate Professor

Masao Omata
Yoshihiro Arakawa

Department of Medical Social Service and Welfare
Professor

Yasuyoshi Ouchi

Department of Planning, Information and Management
Professor

Kazuhiko Ohe

Department of Organ Transplantation Service
Associate Professor Norihiro Kokudo
Associate Professor Yasuhiko Sugawara

Pharmacy
Pharmaceutical Department*
Professor
Associate Professor

Hiroshi Suzuki
Kousei Ito

Nursing Department
Administration Office

11

12

Faculty of Medicine
Graduate School of Medicine
The University of Tokyo

Graduate School of Medicine

Molecular Cell Biology...............................................14
Functional Biology .....................................................16
Pathology, Immunology and Microbiology ....................18
Radiology and Biomedical Engineering ........................20
Neuroscience ...........................................................22
Social Medicine ........................................................26
Internal Medicine .....................................................28
Reproductive, Developmental and Aging Sciences ........32
Surgical Sciences .....................................................36
Health Sciences and Nursing .....................................42
International Health ..................................................48
School of Public Health .............................................52
Center for Disease Biology and Integrative Medicine .....54
University Hospital

Central Clinical Facilities ............................................58
Pharmacy .................................................................60
Center

Health Service Center.................................................61
The International Research Center for Medical Education
and Research .............................................................61

13

1

A
G
C
T

Molecular Cell Biology

Cell Biology and Anatomy ——————————————————————————————————————
http://cb.m.u-tokyo.ac.jp/

Cells transport various kinds of proteins, lipids and mRNAs after synthesis to their specific destinations such as several types of membranousorganelles, protein complexes and the mRNA complex. Thus, intracellulartransport is fundamental to cellular functions, survival and morphogenesis. Our laboratory is studying the mechanisms of intracellular transportand cellular morphogenesis, especially focusing on molecular motors,
Kinesin superfamily proteins (KIFs) and microtubule associated proteins(MAPs) using molecular cell biology, biophysics, structural biology, andmolecular genetics.

• Molecular cell biological study of KIFs
• Studies of the mechanism for recognition of and binding to cargoes by KIFs and theregulation of this mechanism• Studies of the mechanisms of differential directional transports and sorting• Studies of the dynamics and mechanism of motility of KIFs using molecular biophysics and structural biology• Molecular genetics of KIFs
• Studies of KIFs and related diseases• Molecular cell biology and molecular genetics of MAPs

Quick freeze-deep etch electron micrographof a mouse nerve axon showing a microtubule (25 nm diameter, linear tube-likestructure) and a cross-bridge linking the
microtubule and a membranous organelle.
Microtubules are a major component of thecytoskeleton and serve as a type of railalong which motor proteins transportorganelles inside cells. (Reproduced fromthe cover of Science vol. 279, Jan 23 1998.)

Cellular Neurobiology —————————————————————————————————————————The Laboratory of Cellular Neurobiology is interested in understanding the molecular mechanisms regulating synapse formationand maintenance, which are essential in proper function of neuralcircuits in the brain. The laboratory is using optical imaging ofsynaptic molecules in live neurons, in combination with molecular biological approaches to modify neuronal functions.

• Molecular architecture of the postsynaptic density• Molecular mechanisms of activity-dependent synapse remodeling• Regulation of synapse functions by glial cells• Regulation of synapse formation and maintenance in vivo

Quantitative fluorescence imaging of cultured hippocampal neurons (green: postsynaptic protein andcalibrated fluorescent microspheres, red: presynaptic
protein, blue: microtubule-associated protein)14

Molecular Biology ————————————————————————————————————————————
http://www.cellcycle.m.u-tokyo.ac.jp

With the goal of understanding the molecular mechanisms controlling growth and differentiation,
we have been studying the cell cycle with cultured
mammalian cells and fission yeast as model systems.

• Understanding the molecular mechanism enabling the anchorage-independent S phase onset that is the key for malignant
transformation• Understanding the G1 and G2 cell cycle checkpoint controls• Understanding the molecular switch between growth and differentiation

Eukartotic cell cycling

Cellular Signaling —————————————————————————————————————————————
http://biochem2.umin.jp

Our laboratory specializes in biochemistry, molecular and cellular biology, and genetic engineering
to elucidate the roles of lipid mediators in vivo . In collaboration with the Department ofMetabolome, we analyze stimulus induced dynamic changes in the lipid composition of the cellular
membrane.

• Discovery and structural determination of novel lipid mediators• Cloning, functional characterization and K/O studies of receptors for lipid

mediators• Cloning, functional characterization and K/O studies of enzymes involvedin the metabolism of lipid mediators• Functional regulation of GPCR
• Roles of lipid mediators in the central nervous and immunological systems

Melanocytic tumor in platelet-activating factor receptor
transgenic mice

Physiological Chemistry and Metabolism ———————————————————————————
http://bio.m.u-tokyo.ac.jp/

Developmental and regenerative medicine group is investigating the molecular mechanisms ofembryogenesis and is establishing a unique basis for regenerative medicine; metabolic regulationgroup is studying the signaling mechanisms regulating metabolism and cell growth to develop new
therapy for metabolic syndrome.

• Developmental biology and regenerative medicine• Neural crest development and formation of the branchial arch and cardiovascular system• Reprogramming in early embryogenesis• Organogenesis and regeneration of vessels, inner ear and lung
• Establishment and analysis of disease model mice
• Establishment of therapeutic cloning models in mice

• Metabolism regulation and pathophysiology• Analysis of protein complexes in intracellular signaling and transcription• Proteomics and localization analysis of proteins constituting intracellularorganelles• Analysis of a novel Akt-binding protein, APE• Molecular mechanisms of insulin-resistance in metabolic syndrome

Transfer of somatic nuclei into enucleated mouse oocytes
using a Piezo-driven micromanipulator

15

2

Functional Biology

Integrative Physiology —————————————————————————————————————————
http://www.physiol.m.u-tokyo.ac.jp/indexe/indexe.html

Our laboratory specializes in the neuroscience research on cognitive functions in the primate. We
investigate interactions among many neurons in the cerebral cortex, which create human cognitive
abilities such as memory and its cognitive control. These studies
have been done through integrative efforts using electrophysiological, molecular biological and neuroimaging approaches.

• Functions of memory neurons in the temporal cortex• Roles of the top-down signal from the prefrontal cortex• Functional differentiations of the prefrontal cortex in memory• Molecular biological basis of declarative memory in the primate• Development of high-field MRI for humans and monkeys

Brain activation in cognitive tasks (left) and gene
expression (BDNF) in cortical neurons

Cellular and Molecular Physiology ————————————————————————————————
http://morilab.m.u-tokyo.ac.jp/eindex.html

We aim at a better understanding of neuronal mechanisms involved in sensory perception of theexternal world and for the emotional state induced in the brain by sensory inputs. We are currently
analyzing the central nervous system for olfaction, a sensory modality that has a strong influenceon human emotion. Another major focus is to understand cellular and molecular mechanisms forcontact-mediated interactions between neurons and immune cells that occur in pathological andphysiological conditions.

• Functional analysis of the neuronal circuit in the central olfactory nervous system (Analysis of odor maps in the brain)• Neurogenesis and neuron-elimination in the adult brain• Molecular and cellular mechanisms for the axonal recognition of spe-cific target neurons and for the formation of specific neuronal circuits• Cellular and molecular mechanisms for the contact-mediated interac-tions between neurons and immune cells in physiological and pathological conditions

Neuronal circuits and 'odor maps' in the olfactory nervous system

16

Neurophysiology —————————————————————————————————————————————
http://plaza.umin.ac.jp/~neurophy/

Our laboratory studies the function of the synapse, a key structure for brain functions, and itschanges related to postnatal development, learning, and memory. We make real time monitoring of
neuronal activities, using various methodologies including
electrophysiology, molecular biology, and optical imaging offunctional molecules.

• Postnatal development of synaptic function and organization in the cerebellum• Retrograde synaptic modulation mediated by endogenous cannabinoids• Crosstalk between G-protein-coupled receptors• Synaptic integration in intact animals• Synaptic plasticity and motor learning in the cerebellum

Molecular mechanisms of endocannabinoid-mediated retrograde modulation of synaptic transmission

Cellular and Molecular Pharmacology ——————————————————————————————
http://calcium.cmp.m.u-tokyo.ac.jp/

Spatiotemporal distribution of signalling molecules is extremely
important in defining cell signals. We are developing indicators ofimportant signalling molecules and visualize their spatiotemporal
distribution within intact cells. Using such novel imaging methods
we aim at elucidation of the physiological roles of calcium signalling and related signalling mechanisms in various types of cells
including neurons of the central nervous system.

• Development of genetically coded indicators of important cell signals• Molecular approaches to the study of IP receptor-mediated Ca signalling• Elucidation of the relationship between Ca signalling and cell functions• Visualization and analysis of molecular events at synapses
2+

3

2+

Imaging of synaptically induced nitric oxide dynamics
in cerebellar Purkinje cell

Molecular Neurobiology————————————————————————————————————————
http://www.pharmacol2.m.u-tokyo.ac.jp/

We have been investigating the molecular basis of higher brain functions by focusing on the glutamate receptor and memory. Previous studies have led to the hypothesis that there is a common
principle between memory signaling and synapse formation. The combination of conditional genetargeting in mice and molecular genetics in zebra fish will facilitate our understanding of the mechanism of higher brain function at the molecular, cellular and neural network levels.

• Regulation of brain functions by glutamate receptors in specific brain
regions• Identification of neural networks for learning and memory• Regulation of learning and memory• Roles of glutamate receptors in decision-making• Signaling from glutamate receptors to memory• Molecular mechanisms of synapse formation and remodeling• Molecular mechanism of synapse formation during development• Molecular mechanism of synapse remodeling in the adult brain
Glutamate receptor δ2 selectively expressed in cerebellar
Purkinje cells

17

3

Pathology, Immunology andMicrobiology

Human Pathology and Diagnostic Pathology ————————————————————————
http://pathol.umin.ac.jp/index_e.htm

We investigate the pathogenesis and pathobiology of disease, especially the neoplastic diseases, bymeans of morphology. Our goal is to discover new entities and to clarify unknown pathogenesis of
diseases through the interaction with clinical medicine.

• Chronic inflammation and neoplasm• Epstein-Barr virus associated gastric carcinoma• Epigenetics of carcinoma• Carcinoma-stromal interaction• Lung adenocarcinoma and its scar formation• Lung fibrosis and adenocarcinoma
Applicationof molecular pathology to pathological diagnosis•
Discoveryof cancer therapy target by DNA chip technology•• Establishment of objective criteria for cancer grading• Streamlining and acceleration of pathological diagnostic processes

Investigation of the development of EB virus-associated gastriccarcinoma

Molecular Pathology ——————————————————————————————————————————
http://beta-lab.umin.ac.jp/index.htm

Our research is focused on the molecular mechanisms of carcinogenesis. We study the signaling
β superfamily, including TGF-β
β and bone morphogenetic proteins (BMPs),
mechanisms of the TGF-β
and elucidate how they regulate progression of cancers. We also investigate the mechanisms of differentiation of murine embryonic stem cells (ESCs) into various cells, including vascular and lymphatic endothelial cells. Based on these findings, we will develop new strategies for the treatmentof vascular and lymphatic diseases and cancer.

• Negative regulation of TGF-β signaling by inhibitory Smads andoncogene c-Ski• Molecular mechanisms of growth regulation by TGF-β• Roles of TGF-β in epithelial-to-mesenchymal transition• Differentiation of mouse ESCs into vascular cells• Roles of TGF-β superfamily cytokines in vascular and lymphatic
diseases• Differentiation of vascular and lymphatic endothelial cells andmechanisms of diseases

Signaling by TGF-β receptors and Smad proteins18Microbiology ————————————————————————————————————————————————
http://microbiology.m.u-tokyo.ac.jp/

Our major objective is elucidation of the molecular mechanisms for replication and pathogenesis of
RNA viruses, such as poliovirus and hepatitis C virus. Based on theoutcome, we will develop new strategies against those viral diseases.

• Roles of the human poliovirus receptor in poliovirus infection• Molecular mechanisms for the dissemination pathways of poliovirus• Molecular mechanisms for the replication of poliovirus in neurons• Molecular mechanisms for the development of hepatocellular carcinoma following
hepatitis C virus infection• Replication mechanisms of the hepatitis C virus RNA replicon• IRES (internal ribosome entry site) activity-dependent virus tropism• Host and viral protein synthesis during poliovirus infection

Three-dimensional structure of poliovirus(Courtesy of James M.Hogle)

Infection Control and Prevention —————————————————————————————————We are engaged in education of medical staff as wellas in daily clinical activities on the preventionof healthcare-associated infection (HAI). Research activities on the pathogenesis of infection with
hepatitis viruses and HIV, in particular, on the mechanism of hepatocarcinogenesis in HCV infection
are also our mission.

• Development of preemptive strategies for the control of healthcareassociated infection• Development of new methods in infection control and treatment ofviral hepatitis• Molecular pathogenesis of hepatocellular carcinoma in HCV infection• Pathogenesis of progression of HIV infection• Molecular pathogenesis of the mitochondrial disturbances in viral
infections• Molecular pathogenesis of hepatitis B viral infection• Host defences to microorganisms• Molecular analysis of innate immunity in microorganism infection• New detection method and pathogenesis of opportunistic cytomegaloviral infection• Mechanism of multi-drug resistant microorganisms

Infection control teamroundsImmunology ————————————————————————————————————————————————
http://www.immunol.m.u-tokyo.ac.jp/english

Since the original identification of two cytokine genes, interferon-β andinterleukin-2, our laboratory has been continuing to elucidate the regulatory mechanisms of signal transduction and transcription in these andother cytokine systems in the context of immunity and oncogenesis.
More recently, we have also initiated a project on spatiotemporal regulation in lymphocytes and antigen-presenting cells in the context ofcytokine signaling cross talk.

• The mechanisms of signaling and transcription networks operating in the IFN-α/βsystem in innate immune responses• The function and regulation of the transcription factor family, i.e., the interferon
regulatory factors (IRFs), in innate and adaptive immune responses, such as Th1/Th2
differentiation mechanism, natural killer (NK) cell differentiation• The mechanisms of regulation of antigen-presenting cells (APCs), typically dendrite
cells (DCs), by IFN-α/β and other cytokines and toll-like receptors (TLRs)• The regulation of oncogenesis by IFN-α/β and the tumor suppressor p53, particularly
their mutual cooperation and function on target genes (Noxa etc.)• Regulation of hematopoiesis and autoimmunity by IFNs and IRFs
• Spatiotemporal regulation of the TLR and cytokine signaling in lymphocytes andantigen-presenting cells

Spatiotemporal regulation of the TLR9-IRF-7
pathway in dendritic cells.
The TLR9 ligand CpG-A DNA is retained inendosomes of plasmacytoid dendritic cells (orIFN producing cells), wherein the labeled CpG-A
merges with IRF-7 transcription factor. This is
critical to sustain the TLR9 signal for prolonged
activation of IRF-7 to efficiently induce IFN-α/β
genes (left). On the other hand, in conventional
dendritic cells, CpG-A undergoes rapid trafficking to lysosomes, therefore these cells fail toachieve high-level IFN-α/β induction (right).

19

4Radiology and Biomedical Engineering

Radiology ——————————————————————————————————————————————————
http://www.ut-radiology.umin.jp/

We have been performing a variety of clinically oriented research programs in biomedical imaging,voxel-based or ROI-based analysis, information analysis and radiotherapy, such as computer-assisted diagnosis (CAD), PET-based diagnosis, and intensity modulated radiotherapy (IMRT).

• Diagnostic Radiology• Multi-row detector (up to 16 rows) helical computed tomography• MR imaging, MR digital subtraction angiography, perfusion imaging, anddiffusion tensor imaging/tractography
Radiation
Oncology•
Physicalengineering aspect of radiotherapy•• Stereotactic irradiation by gamma knife and synergy system and IMRT
• Clinical and biological studies for reduction of radiation-induced damage
Nuclear
Medicine•• Functional imaging by radioisotope-labeled tracer technology• Evaluation of blood flow and metabolism by emission tomography (PET and
SPECT)
Representative images analyzed with computerassisted technology

System Physiology ————————————————————————————————————————————
http://bme-sysphysiol.m.u-tokyo.ac.jp/

A variety of living cells respond to mechanical forces occurring both inside and outside a body. We
have been pursuing biomechanical research focusing on the effects of shear stress generated byflowing blood on vascular cells and circulatory functions. Our analyses range all the way from genes
to whole organs and systems. Research on the molecular mechanism of artherogenesis and biomechanical tissue engineering is
also ongoing.

• Vascular cell responses to shear stress• Identification of flow-sensing molecules• Mechanical stress responsive genes• Tissue engineering using mechanical stresses• Atherosclerosis research from the aspect of hemodynamics• Vascular system physiology• Microcirculation study using optical imaging

Mechanical force-loading apparatus and calcium response
in vascular cells

20

Biosystem Construction and Control ———————————————————————————————
http://www.bme.rcast.u-tokyo.ac.jp/index_e.html

Our research fields include medical engineering technologies represented by artificial organs.
Especially the research of artificial heart has gotten excellent results such as the world longest survival record in animal replaced with a total artificial heart. We are performing the researches fromthe basic to the application.

• Implantable total artificial heart• Implantable ventricular assist device• Polymer artificial valve• Next generation artificial lung
• Tissue engineered artificial organs• Blood compatible material• Implantable pressure sensor• Implantable angiogenesis observation probe• Space medicine• Laser surgery and medicine
Implantable total artificial heart (Undulation pump total artificial heart) and artificial heart animal (goat)21

5

Neuroscience

Neuropathology —————————————————————————————————————————————
Elucidate the pathomechanism of neuronal degeneration and death inmajor neurodegenerative disorders (e.g., Alzheimer disease, Parkinson
disease), and develop novel strategies for disease-modifying therapies.

• Structural and functional analysis of γ-secretase• Molecular analysis of the mode of action of γ-secretase inhibitors• Mechanism of Aβ production, aggregation and clearance• Pathological function of β-amyloid binding proteins (e.g., CLAC)• Mechanism of aggregation and neurotoxicity of α-synuclein• Pathological function of familial Parkinson disease gene LRRK2• Strategies for development and validation of disease modifying therapies for
Alzheimer disease

Identification of phosphorylated α-synucleinin Lewy bodies
Phosphorylated α-synuclein deposited in Lewy
bodies of Parkinson's disease

Neurochemistry ——————————————————————————————————————————————
http://www.neurochem.m.u-tokyo.ac.jp/Homepage.html

Our brain is able to recognize and memorize external and internal events as they occur. A functional
neural network further stands out by its capacity to extract patterns and rules, and to associatethem with abstract meaning and affective valence. What are the local and global spectra of themolecular signaling events in neurons that underlie such complex
information processing at the systems level? Are these events, in turn,converted into more profound modifications of the synaptic wiring
mechanisms? To address these issues, we are currently investigating
the chemistry and physiology of various neuronal protein complexes
near and at synapses.

• Molecular investigation (including identification, characterization and real-timevisualization) of signaling molecules involved in calcium-dependent synaptic modification, especially during signaling from synapse-to-nucleus, and back from nucleus-to-synapses• Understanding molecular mechanisms controlling cytoskeletal dynamics andremodeling on both sides of the synapses, in the dendritic spines and in axon terminals

22

Real-time measurement of biochemical events
triggered by glutamate uncaging at hippocampal spines (A); Visualization of actin cytoskeleton in cerebellar Purkinje cell dendrites (B)Cognitive Neuroscience ————————————————————————————————————————
http://square.umin.ac.jp/dcntky/English/Etop.html

We are trying to understand the neural mechanisms of human cognition using functional MRI, EEG
and TMS.

• Working memory and cognitive control• Attention, perception and consciousness• Theory of mind and social behavior• Mind-reading and prediction of behavior

Neuropsychiatry —————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts.html

Our department has provided a leading role in biological psychiatry of stress-related disorders andschizophrenia. Recently, we have promoted cutting-edge biological studies of pervasive developmental disorders.

• Genetic, molecular, and neuroimaging studies of pervasive developmental
disorders• Molecular biology of epilepsy and stress-related disorders• Genetic studies in schizophrenia, autism, and anxiety disorders• Multimodal neuroimaging studies of schizophrenia, PTSD, and autism• Clinical psychopharmacology• Molecular studies in sleep-related disorders• Clinical studies on dementia and schizophrenia

Multi-modality neuroimaging in neuropsychiatry using a combination of high-resolution MRI, EEG, MEG, NIRS, and PET

Neurology ——————————————————————————————————————————————————
http://square.umin.ac.jp/neurotky/

Our Department is promoting research programs to elucidate the pathophysiological mechanisms ofneurological diseases including neurodegenerative diseases, immune-mediated diseases and neuromuscular diseases, and to establish therapeutic approaches for these diseases. We are also providing excellent programs to train neurologists.

• Molecular Genetics (identification of disease genes and development oftherapeutic approaches)• Molecular pathopysiology of neurological diseases (RNA editing, and protein structures)• Immune-mediated diseases (autoantibodies)• Neuropysiology and cognitive neuroscience (magnetic stimulation,
NIRS, MEG, PET, and fMRI)• Neuropathology of neuromuscular diseases (pathological studies on
biopsy and autopsy materials)• Multicenter-based clinical research• Development of new therapeutics

23

Neurosurgery————————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/neurosurg/

The 21st century has been designated as "The Century of the Brain". To lead Japanese Surgical
Neuroscience, we have devoted our activities to the following: advanced Clinical Neurosurgery,
Neuroscience Research and Graduate and Postgraduate education.

• Advanced Clinical Neurosurgery• Skull base surgery in managing benign or malignant skull base tumors andcerebrovascular disorders• Advancement of less invasive surgical techniques to maintain the quality oflife (QOL) of patients : application of endoscopy and γ-knife radiosurgery• Development of new therapeutic strategies for malignant glioma• Functional neurosurgery including epilepsy surgery• Neuroscience Research• Application of stem cells in regenerating damaged neuronal networks• Treatment of brain tumors using conditionally replicating virus vectors andnano drug delivery systems• Tailor-made therapy of malignant brain tumors using genetic analyses
Endonasal endoscopic pituitary surgery under navigation
guidance24

25

Social Medicine

Molecular Preventive Medicine ——————————————————————————————————
http://www.prevent.m.u-tokyo.ac.jp/

Chemokines play critical roles in the pathogenesis of diseases including acute inflammtaion,
autoimmune diseases, allergic diseases, HIV infection, atherosclerosis and tumor metastasis
through the regulation of chemotaxis, activation and differentiation. We hope chemokine research
will contribute to Molecular Preventive
Medicine.

• Pathogenesis of diseases by chemokine• Autoimmune diseases, liver injury, GVHD
• Atopic dermatitis, bronchial asthma• Activation of the chemokine receptor and its signaltransduction• Serial analysis of gene expression (SAGE) for hematopoietic cells• Development of vaccinations to cancers and infectious
diseases

Public Health ————————————————————————————————————————————————
http://publichealth.m.u-tokyo.ac.jp/

Public health is the science and art of preventing disease, prolonging life, promoting health, andquality of life (QOL) through organized community effort. Through studies in various fields and laboratories, our department aims to advance research, support policy development, and promote education toward
these ends.

• Efficiency and equity issues of health services• Health manpower policy• Occupational and environmental health• Policy analysis on health and environmental issues• Clinical epidemiology (QOL, outcome studies, economic evaluation)

A Malay farmer with a pesticide sprayer on his back and a tobacco
farm, subjects of one of our health surveys

26

Forensic Medicine ————————————————————————————————————————————
http://plaza.umin.ac.jp/~forensic/

Our practice is to determine the cause of unusual death by autopsy and examinations. For the
progress of the practice, we are pursuing molecular pathological studies on sudden cardiac deathand sociomedical studies on the death investigation system and risk management.

• Ischemic death of cardiomyocyte• Toxic or protective role of carbon monoxide• Oxidative stress and lipid peroxidation in pathogenesis• Law and system of death investigation and medical risk management• Analytical toxicology

Forensic autopsy room

Medical Informatics and Economics ———————————————————————————————
http://www.m.u-tokyo.ac.jp/medinfo/index_e.html

The department continually develops and manages the entire clinical and administrative information system of the University of Tokyo Hospital such as hospital management works. The researchand postgraduate education programs cover basic medical informatics, advance applications of
information technology to clinical medicine, technology assessment and standardization of healthcare information.

• Development of the new architecture of our hospital information system
is based on distributed computing technology• Development of intelligent computer-based medical record systems• Standardization of medical terminology and communication protocol forelectronic exchange of healthcare information• Patient-centered medical information systems• Development and management of a clinical data collection system using
the University Hospital Medical Information Network(UMIN)

Computer room of the hospital computer center

27

6Internal Medicine

Cardiovascular Medicine ———————————————————————————————————————
http://plaza.umin.ac.jp/~utok-card/

We are investigating the pathogenesis, pathophysiology, diagnostic methods, and novel therapeuticmeasures of various cardiovascular diseases (ischemic heart disease, heart failure, cardiomyopathy,
arrhythmias, atherosclerosis, hypertension, etc.) using a variety of research tools (from molecularbiology to epidemiology, bioinformatics).

• Transcriptional regulation of various genes in cardiovascular development
and pathogenesis
hypertrophy and heart failure: analyses of pathogenic mechanisms• Cardiacand developments of novel therapies (gene therapy, etc.)• Immunological basis of cardiovascular diseases• Imaging techniques (echocardiography, MRI, RI, NOGA) in cardiovasculardiseases• Mechanisms of anti-arrhythmia therapy• Molecular mechanisms of ischemia-reperfusion injury• Genetic polymorphisms and risk factors in cardiovascular disease• Differentiation of smooth muscle cells (atherosclerosis and restenosis after
vascular interventions)• Mouse genetic models of cardiovascular diseases and vascular development
Intraventricular mapping using the NOGA system• Neurohumoral factors in cardiovascular diseases
Respiratory Medicine ——————————————————————————————————————————
http://kokyuki.umin.jp/

Based on the fact that a number of patients with respiratory diseases including lung cancer and
COPD is tremendously increasing, fruitful results of respiratory research are more and more expected in the 21st century. In this era, we are conducting basic and clinical researches for wide variety of
respiratory disorders including lung cancer, asthma and COPD. Especially, we have been intensively
studying the molecular mechanisms underlying the pathogenesis of lung disorders. Our researchgoal is to develop novel therapeutic tools to manage these pulmonary diseases.

• Clinical studies of lung cancer, COPD, bronchial asthma and pulmonary fibrosis
studies of diffuse panbronchiolitis (DPB) and interstitial• Epidemiologicallung disease• Molecular mechanisms underlying the pathogenesis of acute lung injury or ARDS
• Molecular mechanisms underlying the pathogenesis of pulmonary fibrosis(as shown in Figure)• Analysis of disease models using genetically-engineered mice
• Effects of air pollutants such as diesel exhausts on airway hyperresponsiveness Roles of chemokines/cytokines and eicosanoids on airway epithelial
cells, smooth muscle cells and eosinophils.
• DNA methylation and lung cancer• Establishment of conditional vectors for hairpin siRNA knockdowns• Establishment of CpG island searcher

28

Murine model of pulmonary fibrosis

Gastroenterology ————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/gastro/

Our Department of Gastroenterology is one of the top institutions in the world in the treatment of
hepatocellular carcinoma by unique ablation(RFA) and gastrointestinal/pancreatobiliary cancer/stone byendoscopic manipulation(ESD&ERCP). The goal of our department is to accurately diagnose and givethe best available treatment to these patients, and to this end, we are performing a wide variety ofbasic as well as clinical research.

• Development of better therapeutic strategy for hepatitis B and C• Elucidation of liver injury mechanisms in viral hepatitis• Development of a better therapeutic modality for hepatocellular carcinoma& metastatic liver tumor• Elucidation of gastric injury mechanisms by Helicobacter pylori• Clarification of colon disease, especially right-sided colon carcinogenesis• Development of therapeutic strategy for advanced pancreatobiliary cancer• Development of a better endoscopic therapeutic modality forpancreatobiliary cancer/stone• Development of better diagnostic & therapeutic strategy for chronic pancreatitis• Development of an endoscopic en bloc resection method for early gastric,
esophageal and colonic cancer• Elucidation of the mechanisms of hepatic fibrosis and liver regeneration• Development of better diagnostic & therapeutic strategy for small intestinal diseases

Nephrology / Endocrinology —————————————————————————————————————
http://plaza.umin.ac.jp/~kid-endo/top.html

We are investigating the pathophysiology of renal and endocrine disorders for the development ofinnovative diagnostic and therapeutic tools. Hypertension is our special interest because not only is
it a serious medical problem which impairs many vital organs and the QOL of our patients, but also
we have the great advantage of organizing the strategic research aproach since hypertension isclosely related with both nephrology and endocrinology.

• Renal physiology and morphology• Pathophysiology of immune-mediated renal injury• Analysis of pathophysiology and prognistic factors of chronic renal failure• Endothelial injury and vascular biology in kidney disease• Role of nitric oxide and oxidative stress in renal disease and hypertension• Clinical and basic investigation of bone and mineral disorders• Mechanism of action of nuclear hormone receptors• Pathophysiology of hypertension and roles of adrenomedullin• G protein signaling in health and disease
Nutrition and Metabolism ——————————————————————————————————————We are investigating to reveal the molecular mechanisms underlying the development of metabolic
diseases (diabetes mellitus, lipid metabolic disorders, obesity, metabolic syndrome and atherosclerosis) using interdisciplinary approaches and state-of-the-art technology including genetically engineered model animals, DNA chip, RNA technology, human genetics, clinical epidemiology and bioinfomatics. Our major goal is to develop mechanism-based fundamental treatment and prevention strategies for the metabolic diseases.

• Molecular mechanism of insulin resistance linked to obesity focusing on

adipokines• Transcriptional regulation of insulin resistance and obesity by nuclear receptors
and cofactors• Molecular mechanism of insulin signal transduction• Molecular mechanism of insulin secretory defect in type 2 diabetes• Genetic susceptibility and risk factors of type 2 diabetes• Development of accurate diagnostic algorithm for type 2 diabetes• Molecular mechanism of adipogenesis and obesity• Transcriptional regulation of lipid metabolism• Molecular mechanism of atherosclerosis• Mouse genetic models of diabetes, lipid metabolism disorder and atherosclerosis

29

Hematology and Oncology——————————————————————————————————————
http://www.h.u-tokyo.ac.jp/mukin/E-index.htm

We are investigating the pathogenesis, diagnostic methods, and novel therapeutics of hematologicaldisorders by making comprehensive use of research technologies in molecular biology, developmental biology, and immunology. We are also performing basic and clinical studies based on
genomics, regenerative medicine, and transplantation medicine, which aim at application to therapeutic strategies.

• Self renewal and differentiation of hematopoietic stem cells• Establishment of ex vivo expansion of hematopoietic cells• Genome-wide analyses of hematological malignancies• Identification of molecular pathogenesis of leukemia• Identification and regulation of leukemic stem cells• Analyses of the immune system by developmental biology• Establishment of antigen-specific immunological therapeutics against
cancer• Development of therapeutic strategies for GVHD by engineered
immune cells

Transcription factor AML1 in normal hematopoiesis and leukemia

Allergy and Rheumatology——————————————————————————————————————
Allergy and rheumatic diseases are immune mediated disorders. We are investigating the fine mechanisms of such disorders. One of our final purposes is to establish novel therapies which control
pathological immune disorders but do not suppress other physiologically important immune functions. We are combining recent findings in basic immunology andour own viewpoints base on our clinical experience.

• Clonal analyses of T cell receptor (TCR) , in vitro reconstitution of the TCR

function using such information and antigen specific immunotherapy
Mechanismsof oral tolerance and application to therapeutic strategies•• Mechanism of immunological tolerance to autoantigens and immunoregulation• Development and induction of regulatory T cells and their applications• Intracellular signaling in immune disorders• Genomic analyses of rheumatic diseases• Development of molecular targeting immunosuppressive reagents• Airway hypersensitivity and remodeling of bronchial asthma• Mechanisms of IgE mediated allergic disorders and applications for therapies• Involvement of chemokines in allergic diseases and applications to therapeuticstrategies

Clonal analyses of T cell receptor (TCR) and in vitro
reconstitution of the TCR function for an antigen
specific immunotherapy

Infectious Diseases ————————————————————————————————————————————We are investigating both clinical and basic aspects in infectious diseaes, in particular, on HIV infection and hepatitis viral infections, the latter of which is the major cause of liver diseae worldwide.
Our research topics cover the wide areas in microbiology, immunology and pathobilology of infectious diseases, including HIV and HCV infections.

• Clinical studies of HIV infection• Development of new methods in infection control and treatment of viral hepatitis• Molecular pathogenesis of hepatocellular carcinoma in HCV infection• Pathogenesis of extrahepatic manifestations and its control in HCV infection• Pathogenesis of progression of HIV infection• Molecular pathogenesis of the mitochondrial disturbances in viral infections• Molecular pathogenesis of hepatitis B viral infection• Host defences to microorganisms• Molecular analysis of innate immunity in microorganism infection• New detection method and pathogenesis of opportunistic cytomegaluviral
infection• Mechanism of multi-drug resistant microorganisms

30

Stress Sciences and Psychosomatic Medicine ————————————————————————
http://psmut.umin.ac.jp/

Targeting stress-related diseases such as psychosomatic and lifestyle-related diseases, we are investigating their pathophysiology and psychopathology through assessing higher brain function, autonomic nervous function, and bio-psycho-behavioral time-series data. We are also actively conducting
basic as well as clinical research on stress and relaxation responses and eating-related substances.

• Elucidation of brain processes closely related to mind/body correlation in stress-

related diseases by use of brain functional analysis methods such as positronemission tomography, magnetoencephalography, and event-related potentials• Investigation into the pathophysiology, psychopathology and neurobehavioral basisof stress-related diseases by use of ecological momentary assessment methods• Behavioral scientific studies and interventional studies using psychobehavioral
treatment procedures on stress-related diseases• Development and clinical application of questionnaires concerning mental health• Interventional studies of various relaxation procedures• Psychophysiological and biochemical studies on stress responses and relaxation responses• Investigation on the effects of newly-found neuropeptides such as orexin andghrelin in the brain particularly on emotion and stress responses

Clinical Laboratory Medicine ————————————————————————————————————
http://lab-tky.umin.ac.jp/

The main goal of our research projects, described below, is the development of new and useful laboratory
tests, and elucidation of pathophysiology of diseases throughlaboratory tests.

• Elucidation of (patho)physiological roles of lysophospholipid mediators, and its application to laboratory medicine• Platelet biology, Hepatology• Genetic testing• Research on bioactive peptides, especially adrenomedullin• Oxidative stress and organ damage• Cell surface analysis and quantification of cell surface antigens using

flow cytometry• Analysis of the ventricle functions using ultrasound• Relationship between the respiratory function and various pathophysiological conditions• Magnetoencephalographic (MEG) study on neural mechanisms foraudiovisual integration
Flow cytometer and analysis patterns

Transfusion Medicine ——————————————————————————————————————————
http://square.umin.ac.jp/traf-tky/

Control, testing and supply of all blood products for transfusion are the main clinical activities of thedepartment of transfusion medicine, which is responsible for the provision of safe blood products andthe control of the transfusion practice in the hospital. It actively takes part in autologous blood collection, preservation, and supply for patients receiving routine surgery. In addition, apheresis proceduresfor collection of peripheral blood stem cells for transplantation, and of peripheral blood mononuclear
cells for dendritic cell-based vaccine therapy of cancer patients are performed. Also, lymphocyte-based
vaccine is prepared for the immunotherapy of recurrent abortion cases. Special laboratory testings,
including HLA typing (serologic and DNA-based) for bone marrow and organ transplantations and thedetection of anti-HLA, anti-platelet (HPA) and anti-granulocyte antibodies, as well as the phenotyping
and genotyping of platelet- and granulocyte-specific antigens for patients with adverse reactions after
transfusion, are performed. The research fields include 1) the development of immunological methods
for antigen-antibody testing of red cells, lymphocytes, granulocytes, platelets and endothelial cells, 2)
the development and clinical application of dendritic cell-based and other vaccines for immunotherapyof cancer, and 3) the development of new anti-thrombotic materials for clinical use.

• Detection of platelet alloantigens and alloantibodies /• Detection of leukocyte alloantigens and alloantibodies• Detection of anti-endothelial cell antibodies and investigation on their clinical relevance• Development of a novel method for the evaluation of platelet function• Dendritic cell-based immunotherapy for malignant diseases• Development of new anti-angiogenic strategies to treat cancer• Development of new immunotherapeutic approaches to treat malignant diseases• Development of new anti-thrombotic materials for clinical use /• Use of stem cells in regenerative medicine
31

8

Reproductive, Developmental andAging Sciences

Reproductive Endocrinology ————————————————————————————————————
http://square.umin.ac.jp/tkyobgyn/

We manage women's reproductive health comprehensively throughout their respective life stages(adolescence, reproductive ages, menopause, and post-menopause). We also aim to develop
advanced reproductive techniques, which could be practiced with higher success rates andimproved safety, based on experimental and clinical research.

• Establishment of effective and low-risk treatment for infertility• Development of assisted reproductive technology• Interaction between the endometrium and embryo during the implantation period• Pathophysiology of endometriosis• Local regulation of folliculogenesis• Technical development of advanced endoscopic surgery• Development of hormone replacement therapy for postmenopausal
women• Medical treatment for menopausal women

ICSI (intracytoplasmic sperm injection)

Gynecological Oncology ————————————————————————————————————————
http://square.umin.ac.jp/tkyobgyn/

We are developing the intensive surgical management and selection of the most suitablechemotherapy regimen, which improved prognosis of the patients with ovarian cancer. The basic
researches are focusing on the mechanism of gynecological malignancies, especially cervical cancer.
We have identified the tumor suppressors involving in the process of cervical carcinogenesis. We
are investigating a possible clinical application of the vaccine against
human papillomavirus, which is a causative agent of cervical cancer.

• Intensive surgery including pelvic and paraaortic lymphadenectomy• Selection of adjuvant chemotherapy based on the pathological and molecular marker• Tumor suppressors involving carcinogenesis of gynecological malignancy• Analysis of the molecular marker in tumor cells related to clinical behavior• Prevention of cervical cancer using the human papillomavirus vaccines

Expression of tumor suppressor scribble inmalignant cells

32Perinatal Medicine ————————————————————————————————————————————
http://www.iiosan.umin.jp/

The researches are on going for development of precise prenatal diagnosis on the fetal status using
ultrasonography, and for investigation of fetal physiology using animal models. We are also focusing
on the immunological aspects in patho-physiology of pregnancy,
developing the immunotherapy for habitual abortion or gestational toxicosis.

• Early diagnosis of abnormal pregnancy• Development of three dimensional ultrasonography• Experimental fetal physiology• Immunotherapy for pregnancy• Management of complicated pregnancy

Three dimensional ultrasonography of fetus

Molecular Cellular Reproductive Medicine ——————————————————————————We are approaching the molecular mechanisms in various reproductive pathological states, using
the knowledge and techniques of molecular biology, cellular biology and genetics. The studies areproceeding on the effects of endocrine disruptors on reproductive phenomena, such as embryogenesis, spermatogenesis and fetal development, and on the prenatal genetic diagnosis.

• Effect of endocrine disruptors on reproduction• Embryogenesis• Spermatogenesis• Intrauterine fetal development• Prenatal diagnosis using molecular genetics• Molecular mechanisms of embryonic development

Molecular mechanisms of endocrine disruptors

Pediatrics / Developmental Pediatrics ——————————————————————————————
http://square.umin.ac.jp/ped/

We are studying all the issues concerning the health of infants, children and adolescents. We haveachieved very important investigations to clarify the molecular pathogenesis of human congenital
disorders.

• Molecular diagnosis and analysis and collaborative treatment of intractable renal glomerular and tubular diseases• Molecular diagnosis and analysis of hematological malignancy and bone marrow transplantation• Study of Embryonic stem cell (ESC) treatments for various human congenital diseases• Diagnosis, molecular analysis and collaborative treatment of congenital heart diseases• Molecular analysis and collaborative treatment of congenital immunodeficiency
and allergic diseases• Collaborative treatment of extremely premature neonates and babies with pulmonary hypoplasia• Enhancement of the immunological resistance of premature neonates using a
new type of lactobacillus• Diagnosis and treatment of neurological, endocrine and metabolic diseases• Collaborative study and treatment of psychological disorders• Investigation of new systems to promote mother and baby co-relationships during rearing

33

Pediatric Surgery —————————————————————————————————————————————
Pediatric surgical diseases have great variety. In our department all kinds of pediatric surgical conditions are treated, and in these fetal and neonatal surgical care is our main interest. We also treat
many pediatric patients using minimally invasive surgeries such as laparoscopy and thoracoscopy.

• The development and differentiation of the fetal lung
• Fetal diagnosis of congenital malformations• Fetal surgery and treatment• Pediatric minimally invasive surgery• Probiotics and prebiotics applied to padiatric surgical patients• The development and differentiation of intestinal lymphoid organs• Renal functions in congenital hydronephrosis• Biliary atresia and biliary dilatation: their treatment and long-term
prognosis• Surgical treatment of pediatric respiratory malformations

EXIT(ex utero intrapartum treatment):Tracheostomy on a fetus
with laryngeal atresia

Pediatric Oncology ————————————————————————————————————————————
Solid tumors in children are dealt with in our department. Appropriate care strategies combining
surgical treatment and chemotherapy are decided and carried out on various malignant tumors after
extremely close discussion with pediatric oncologists.

• Genetic analysis and investigations for prognostic factors in neuroblastoma• Tumorigenesis in Wilms tumors• Analysis of cellular biology in Wilms tumors• Treatment of rhabdomyosarcoma• Genetic mutation in hepatoblastoma

Microscopic and ultramicroscopic features of Wilms tumor
cell line

Geriatrics ———————————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/1510rounenbyou.html

Our department is the first established department of Geriatric Medicine in Japan. It is our goal totreat all the geriatric diseases, such as atherosclerosis, hyperlipidemia, osteoporosis, senile dementia, diabetes, COPD, and aspiration pneumonia, and to improve the quality of life of elderly
patients.

• Vascular endothelial function and atherosclerosis• Studies of molecular mechanisms in vascular calcification• Antioxidants inhibit vascular smooth muscle cell proliferation andinduce apoptosis• Vascular gene therapy using adenoviral mediated gene transfer of
estrogen receptors• New guidelines for hormone replacement therapy in females in Japan• Novel gene responsible for breast cancer• Novel gene responsible for osteoporosis• Molecular cloning of novel Ring finger protein• Studies of pathophysiology and novel treatment for Alzheimer's disease• Pathophysiological studies on bronchial asthma using gene-targeted mice
• The molecular mechanisms of vascular injury in sleep apnea syndrome

34

35

9

Surgical Sciences

Cardiovascular Surgery, Thoracic Surgery ———————————————————————————
http://ctstokyo.umin.ne.jp/

We are leading in Japan by annual surgery case volume of 550. New knowledge and techniques areactively applied clinically. Many clinical research projects are going on along with routine clinicalactivities. Our laboratories have been also carrying out a large variety of basic research.

• Clinical research• Brain and spinal cord protection in thoracic aortic surgery• Minimally invasive cardiac surgery• Valve or vascular tissue allograft transplantation• Ventricular assist device for end-stage heart failure• Pathophysiology of thymoma• Basic and experimental research• Development of real-time 3D echo
• Development of myocardial regeneration therapy• Analysis of resistance to infection of tissue allograft• Analysis of suppressor gene of lung cancer

MRI diffusion-weighed images of brain by various brain perfusion
techniques

Gastrointestinal Surgery ———————————————————————————————————————
http://todai3ge.umin.jp/

Our research activities range from basic topics to clinical ones with close interconnections. Basic research topics encompass underlying molecular mechanisms
and the regulation of carcinogenesis, progression, metastasis and prevention ofgastrointestinal cancer. Clinical research topics include the establishment of tailored treatment strategies from a patients-by-patient point of view, which ultimately provide a better quality of life while improving survival quality.

• Carcinogenesis, progression, metastasis and prevention of gastrointestinal cancer• Inflammation and gastrointestinal carcinogenesis (gastroduodenal reflux, H. pylori infection)• Are cancer cells derived from bone marrow?
• Earlier detection of cancer and micrometastasis by new genetic markers• Roles of epigenetic alteration (DNA methylation) in gastrointestinal carcinogenesis• Chemoprevention of gastric cancer with PPARγ ligand• Establishment of tailored treatment strategies• Less invasive treatment of early cancer by laparoscopic (assisted) surgery• Sentinel node navigation surgery for early cancer• Extended radical treatment of advanced cancer• Induction of neaoadjuvant chemotherapy and improvement of survival• Estimation of chemotherapy effects by new bio- and genetic-markers• Alternative gastrointestinal reconstruction and estimation of the results

36

Bone marrow cell homing into gastricmucosa of Helicobacter infected mouseHepato Biliary Pancreatic Surgery —————————————————————————————————
http://square.umin.ac.jp/hbp-t/index21.htm

We constantly perfom nearly 200 hepatectomies every year on
patients with hepato-biliary malignancies including hepatocellular carcinoma and metastatic liver tumors. The surgical results can be classified as amongst the highest ranking in the world. In order to improve
the surgical outcome for hepato-biliary-pancreatic malignancies, we
conduct wide areas of research such as analysis of prognostic factors
for liver malignancies, evaluation of liver hemodynamics using ultrasonography, liver ischemia/reperfusion injury, and liver regeneration.
• The development of a radical and safe operative procedure for hepato-biliary
malignancies• The analysis of genetic abnormalities in hepatocellular carcinoma• Development of new methods for the evaluation of liver functional reserve• The evaluation of hemodynamics in the congested liver using ultrasonography• Study of the effect of ischemic preconditioning on liver normothermic
ischemia/reperfusion• Study of the underlying mechanisms of acute pancreatitis using rats
• The prediction of recurrence of hepatocellular carcinoma by measuring AFP
mRNA in the peripheral blood• Induction of hepatocyte differentiation from bone marrow cells

Color flow mapping of intra- Color flow mapping of intraoperative Doppler ultrasonography
operative Doppler ultrasonography before division after transection of the middleof the middle hepatic vein. hepatic vein. Portal flow was hepPortal flow was hepatopetal atofugal (shown in blue) in theveno-occlusive area.
(shown in red).
Bone marrow cells
from the GFP transgenic mouse differentiated into hepatocytes
by coculture with nonparenchymal liver cells.
Bone marrow derived
GFP positive cells
expressed albumin.

Urology ————————————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/urology/

We constantly perform more than 1,000 urological surgeries a year,
including nephrectomy, cystectomy and prostatectomy, with increasing
trend of laparoscopic maneuvers and brachytherapy for organ confined
prostate cancer. Surgical or Non-surgical means are employed for noncancer diseases including renal transplantation, urinary dysfunction,
urinary incontinence, urolithiasis and male infertility. With regard tolaboratory research, not only oncology but also JC virus, PCK diseaseand vascular biology are now under extensive investigation.
• Tailor medicines on estramustine phosphate (EMP) has been investigated for
newly diagnosed advanced prostate cancer (Fig.1)• JC viral genomic analyses and its distribution in the world• Estrogen receptor beta and its metabolic cascade analysis• Hormonal regulation of prostatic proliferation and atrophy
E&H-cadherin correlation with invasiveness of transitional cell carci• Humannoma and prostate cancer• Oncolytic viral therapy using HSV-1 (Fig.2)• PCK disease and genetic analysis• Urolithiasis: ion channels membrane transport (NaDC-1)• Vascular biology and erectile dysfunction (ED)• Fluorescence in situ hybridization (FISH) flow cytometry• Immunotherapy for renal cancer by IL-2 blocking with anti-IL-2-mAb

Fig.1 Overall Survival; EMP 2Cp versus EMP 1Cp + LHRH agonist

Fig. 2 The combination therapy of oncolytic HSV-1 withandrogen ablation led to significantly enhanced inhibition of the tumor growth.

Artificial Organ and Transplantation Division ————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/1512ishokugeka.html

We have performed liver transplantation for end staged liverdiseases. Until March 2007, we have experienced 394 cases ofliving donor liver transplantation and 5 deceased donor livertransplantation case.

• Surgical technique on living donor liver transplantation• Right lateral sector graft• Criteria and technique on middle hepatic vein reconstruction in right livergraft• Vascular reconstruction using homograft vein

• Diagnosis on acute rejection• Artificial Organ• Artificial Liver

The 5-year survival rate in our 320 adult patients who
underwent living donor liver transplantation was 82%,
which was much higher than overall Japan series (70%).

37

Surgical Oncology / Vascular Surgery ——————————————————————————————
http://all-1su.umin.jp/

We had a great deal of experience in treating patients with various cancers and vascular diseases,
and we have performed much research on carcinogenesis, cancer metastasis, immunology,
atherosclerosis, angiogenesis and vascular regeneration. Based on the
research results, we are trying to identify the best way to treat eachpatient with the least surgical stress.

• Development of the novel and order-made therapy for cancer• Genetic mutation analysis of various cancers• Radiosensitivity and chemosensitivity of cancer• Detection of sentinel lymph nodes using magnetic particle• Immunotherapy using dendritic cells• Characterization of tumor vasculature and its therapeutic application• Gene therapy for disseminated metastasis• Drug development to target the receptor and signal transduction cascade of bioactive
lipids• Development of a novel method to diagnose and treat the vascular diseases• Vascular regeneration therapy for atherosclerotic obliterans (ASO)• Visualization of atherosclerotic lesions• Robotics surgery for vascular diseases

Diagramatic representation of clinical-oriented
research, with the ultimate goal of improving
patient QOL

Metabolic Care and Endocrine Surgery —————————————————————————————
http://todai3ge.umin.jp/

Our department has two main divisions. Division of surgical metabolism and nutrition performs
research on vital response to surgical stress and on metabolic and nutritional care during peri-surgical period. Division of breast and endocrine surgery performs surgery for 200 cases of breast, thyroid and parathyroid tumors a year, and performs research on
tumorigenesis, establishment of treatment and prevention of breast
and thyroid cancers.

• Surgical metabolism and nutrition• Induction of tolerance against surgical stress and endotoxemia• Response to endotoxemia through Toll-like receptors• Effects of surgical stress on tumor development• Gender difference in the response to surgical stress• Bacterial translocation during chemotherapy for cancer• Establishment of metabolic care and nutritional support team• Breast and endocrine surgery• Roles of nuclear receptor in development of breast cancer• Micrometastasis of breast cancer• Diagnosis of breast and thyroid tumors by fluorescence in situ hybridization of telomere• Apoptotic gene expression in endocrine neoplasm• Roles of carbohydrate in breast cancer metastasis• Establishment of evaluation on QOL of the patients with breast cancer

Detection of telomere and centromere by Fish. Fluorescencevolume of telomere attenuates with increase of cell division.
(red: telomere, green: centromere, blue: chromosome)

Dermatology ————————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/der/Our department performs very varied of basic and clinical research concerning the cutaneous
immune system that is orchestrated by Langerhans cells, pathogenesis of skin fibrosis in the scleroderma, and mechanism of growth and metastasis of skin cancers (especially in malignant
melanoma). Our specific interest is to develop new therapeutic approaches to the relevant skin diseases using the knowledge we obtain through the data generated by our research .

• Molecules of Langerhans cells that regulate antigen presentation• The role of chemokines in allergic skin diseases• Understanding and clinical application of the regulatory mechanisms of allergy inducing factors produced by the epidermis• Understanding and clinical application of mechanisms of up-regulated expression of
the type I collagen gene in scleroderma fibroblasts• The role of transforming growth factor-β Smad signaling in fibrosis• The role and signal transduction of transforming growth factor-β receptors in dermal
fibroblasts• The mechanisms of up-regulated expression of integrins in fibrosis• Mechanisms of growth and metastasis in malignant melanoma cell lines• Early diagnosis of metastatic lymph nodes by the sentinel lymph node biopsy technique• Early diagnosis of malignant melanoma with dermoscopy
38

Axillary sentinel lymph node in patientswith chest malignant melanoma(2% patent blue staining)Plastic and Reconstructive Surgery ————————————————————————————————
In our lab, we are investigating the mechanisms of morphogenesis of congenital anomalies using adevelopmental biological approach. In addition, we are performing extensive research into the clinical application of engineered tissues such as skin, soft tissue, and cartilage. We also have several
cosmesis-related projects such as clinical hair regrowth with cultured cells and analysis of skinaging mechanisms.

• Basic Research• Mechanisms of embryonic craniofacial morphogenesis• Angiogenesis in embryo and vascular malformations• Mesenchymal stem cells derived from lipoaspirates• Organ engineering with human adult stem cells• Hair regrowth with cultured dermal papilla cells• Research on aging skin-related factors• Regulation of skin aging using hormones and retinoids• Regulation of epidermis by factors derived from dermal fibroblasts• Clinical Research• Ultramicrosurgical reconstruction using vascularized tissue transfers• Reconstructions for established nerve palsy• Cranio maxillo facial surgery• Lymphedema

Microsurgical lymphaticovenular anastomosis(0.5mmφ)
for human arm lymphedema

Oral and Maxillofacial Surgery ———————————————————————————————————
http://plaza.umin.ac.jp/~oralsurg/

Our laboratory has been performing a wide range of clinically oriented research in oral-maxillofacial
disorders such as congenital diseases, jaw deformities and tumors in the oral region. Cartilage andbone regeneration using tissue engineering techniques is our main field of research.

• Clinical research:• Mandibular lengthening by distraction osteogenesis• Correction of facial deformity in patients with cleft lip and palate• Facial growth in craniofacial anomalies• Surgical-orthodontic treatment of dentofacial deformities• Evaluation of the treatment outcomes in patients with cleft lip and/or palate• Basic and experimental research:• Cartilage and bone regeneration using the tissue engineering technique• Gene analysis of congenital anomalies in the oral and maxillofacial region• Effect of free radicals on bone metabolism• COX-2 regulation on bone metabolism• Mandibular lengthening by the floating bone method

Cartilage and bone regeneration using the tissue
engineering technique

Orthopaedic Surgery ——————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/ortho/

Our department was established in 1906 as the first department of orthopaedic surgery in Japan.
Since then our efforts have been dedicated to responding to the needs of patients for orthopaediccare and to related research. Our department seeks to elucidate the molecular and genetic backgrounds of bone and cartilage disorders in order to develop groundbreaking treatments for these
conditions. At the same time, we are attempting to establish various clinical devices.

• Systemic and comprehensive study for osteoarthritis• Bone, cartilage and nerve regeneration• Regulation of anabolic and catabolic bone metabolism by cytokines (FGFs, PGs)
• Molecular mechanism of age-related bone loss (klotho, PPARγ)• Molecular mechanism of osteoclast differentiation and apoptosis (RANKLRANK, INF, Src)

• Gene therapy to control pathological bone destruction (arthritic bone resorption and arthritic joint destruction) using adenovirus vectors• Non-invasive analyzing system to evaluate the mechanical properties ofskeletal system in vivo using CT based finite element analyses• Surgical navigation system with a three-dimensional display and navigation
robot

Surgical navigation system

39

Ophthalmology ——————————————————————————————————————————————
http://plaza.umin.ac.jp/oph/

Our department applies cutting-edge technologies and knowledge to diagnosis and treatment ofeye diseases. To elucidate pathogenesis and establish more efficient ways of diagnosis and treatment of various refractory eye diseases, basic researches utilizing molecular biological, immunological and/or pharmacological techniques and clinical studies utilizing epidemiological, biostatistical
and/or optical methods are conducted. Our efforts are also dedicated to regenerative medicine of
the cornea and retina.

• Investigation of primary glaucomas and relating factors• Development of new methods of glaucoma treatment and validation by RCTof new ocular hypotensive drugs and their mechanism of action• Investigationby using transgenic or KO mice or experimental glaucoma monkeys
of mechanism of neural cell death by using cultured RGCs or retinal• Investigation
glial cells and exploratory search for new neuroprotective agents• Analysis of ocular circulation in glaucoma and retinal diseases• Analysis of corneal topography and wave-front analysis of optical aberrationsof tissue-engineered cornea by using cultured stem cells of• Development
corneal endothelium and epitheliumof molecular mechanism of choroid-retinal neovascularization• Investigationand new drug delivery system for it utilizing nanotechnology• Regenerative medicine of the retina using retinal stem cellsof immune responses in rejection of transplanted cornea and• Investigationrole of chemokines and receptors in uveitis
Otorhinolaryngology and Head & Neck Surgery ——————————————————————
http://www.h.u-tokyo.ac.jp/orl/

Our research is composed of both clinical and basic research. Clinical research is conducted by specialized clinics in the hospital, which experience ear diseases and hearing disorders from neonates
to adulthood, head and neck cancer, paranasal diseases, olfactory and disorders, vertigo and balance disorders and voice and swallowing disorders. Basic and experimental research into molecularbiology, electrophysiology and morphology is conducted in our department's laboratories.

• Clinical research• Cochlear implantation in deaf children and their development of hearing, speech and language• Surgical correction of congenial microtia and atresia and postoperative radical ears to improve
hearing• Quality of life in patients with head and neck cancer to restore speech and swallowing function• Vestibular research on the oculomotor and balance system and myogenic potential• Navigation of the paranasal sinuses and skull base surgery• Surgical treatment of voice and swallowing disorders• Basic and experimental research• Molecular biology of the inner ear• Molecular biology of epipharyngeal cancer and hypopharyngeal cancer• Molecular biology of differentiation and development of inner ear and olfactory epithelium• Origins of vestibular myogenic potential• Aging and regeneration of olfactory epithelium• Binaural hearing
Chochlear implant

Rehabilitation Medicine ————————————————————————————————————————
Our research purpose is to improve the provision of a unique and comprehensive rehabilitation service enabling people to develop their full potential and often returning from being a “patient” tobeing a “person”. Clinically oriented studies concentrate on elucidation of the origin of disabilities
to cause activity limitation and restriction of participation.

• Gait analysis• Measurements of 3 dimensional ground reaction forces with aforce platform• Measurements of foot pressures with a computerized insole sensor system• 2-dimensional image analysis with a video camera system• Cognitive Rehabilitation• Functional localization using event related potential and MEG• Simple evaluation system of higher brain dysfunction• Clinical and biological study on disuse syndromes• Joint contracture and disuse atrophy in molecular biology• Development of a proper program for recovery from deconditioning
2D sagital gait analysis

40

Anesthesiology ——————————————————————————————————————————————
http://www.anes.umin.ne.jp/

We conduct research into various subjects concerned with anesthesia and the pain clinic. There are 6
laboratories in our department. Comprising respiratory, circulatory, nervous and muscular, immune andpain research, and research into anesthetic instruments including monitoring systems.

• Respiratory system Our areas of research include changes in pulmonary vascular resistances in pulmonary edema; and influence ofanesthetic drugs on the pulmonary system; and pathophysiological changes in neurogenic pulmonary edema• Circulatory system Studies are now being perfomed on the relationship between the sympathetic nerve system and cardiac function; the influence of inhibitory enzymes upon organic microcirculations; and the ventilation-perfusion distributions during artificial positive pressure ventilation
Nervous and muscular system Studies are now in progress on the mechanism of epidural-spinal anesthesia(using Hanaoka's needle); the•influence of anesthetics on the auditory brain stem response; the influence of inhalation anesthetic drugs on the autonomic nervous system; and the pharmacology of neuromuscular blocking agents; and the development of a new monitoring system for neuromuscular blockade• Immune system Themes include the response of immune systems to endotoxins inblood and the influences of anesthetics on hepatic Kupffer cells• Pain We have perfomed many studies in this area, including the effects of epidural
drugs on thermal nociception with different stimulus intensity; the clinical applications ofcurrent perceptive thresholds; the mechanism of the analgesic action of laser energy; theclinical applications of drug challenge tests; the examination of the application of epidroscopic therapy; the analgesic mechanism of hyperventilation; the applications of patient
controlled analgesia; the effects of epidural narcotics; and the optimal combination of low
dose opioids and inhalated anesthetics
Anesthesia machines and other medical equipment The development of•simulators
for anesthetic education, and the development of new equipment for tracheal intubation are now in progress

Anesthesia and monitors

Emergency and Critical Care Medicine —————————————————————————————We are collaborating with the School of Engineering, and now concentrating on the development of
the infrastructure of emergency medicine including “the Vital Care Network System”, which allows
us to manage continuously large numbers of high risk patients. We are also making efforts toimprove sterilization and wound healing.

• Vital Care Network System• Telemonitoring system for prehospital medicine• High-performance transfer system for the ambulances• Electrolyzed water• Autonomic nervous system regulation of the heart

41

Health Sciences and Nursing

Health Sociology —————————————————————————————————————————————
http://www.hlthsoc.m.u-tokyo.ac.jp/index.htm

Our department studies social and psychological factors related to health problems and health caresystems, through developing and applying theories, concepts and methods, which have been developed in sociology and social psychology. We carry out studies in interdisciplinary academic fields,
involving health, medicine and nursing as well as the field of sociology.

• Studies on Antonovsky's Salutogenesis and Sense of Coherence (SOC)• Study on medically infected HIV subjects• Studies on the current situation and theories of changing professionalpatient relationship and patient autonomy• Studies on the effects of changes in industrial society on “Ways ofWorking and Living” and fatigue / stress among wokers• Studies on social differences and inequalities in health• Studies on theory and research methodology on the lives of ill and disabled people and their families
An example of a visual presentation on research results

Mental Health / Psychiatric Nursing ———————————————————————————————
Our departments conduct research on mental health and psychosocial stress and provide education/
training of professionals in related fields from global perspectives.

• Mental Health• Mental health epidemiology• Occupational mental health/Occupational health psychology• Psychoeducation/Stress management• Evaluation of school counseling• Practice and Evaluation of Psychotherapy• Early detection and therapeutic education of PDD• Psychiatric Nursing• Supporting people living with mental health problems• Practice and evaluation of home visiting psychiatric nursing• Illness self-management in mental health• Recovery for people with mental illness• Patients' satisfaction with psychiatric services

42

Biostatistics / Epidemiology and Preventive Health Sciences —————————————
http://www.epistat.m.u-tokyo.ac.jp/

Biostatistics and epidemiology provide the methodological basis for health sciences. We are conducting basic methodological research of biostatistics and theoretical epidemiology as well as consultation
works and collaborative projects with basic/clinical researchers. The NPO “Japan Clinical Research
Support Unit” established by the staff of the department is supporting investigator-initiated clinical
trials and large-scale epidemiological studies in respect of data
management, statistics and quality assurance.

• Methodological research• Design of clinical trials• Analysis of correlated data and longitudinal data such as QOL data,
multiple recurrence (events) data
• Analysis of microarray data

• Collaborative projects• Japan Arteriosclerosis Longitudinal Study• Comprehensive Support Project for Oncology Research- Breast Cancer• Comprehensive Support Project for Adequate Treatment of Osteoporosis• Investigator-initiated clinical trials of cell therapies
Multivariate analysis of cDNA-array data

Social Gerontology ———————————————————————————————————————————
http://www.sg.m.u-tokyo.ac.jp/informatione.htm

The three major research areas of this department include social gerontology, psychosocial oncology and biomedical ethics. The faculty and graduate students are multidisciplinary and include those
whose primary training is in nursing, medicine, psychology, anthropology and health sciences.
Using the theories and research methods of those disciplines, we aim to suggest practical ways todeal with a wide variety of public health problems.

• Exchange of social support and subjective well-being among the elderly• Psychological well-being among the elderly who have experienced
relocation• Measurement of active life expectancy• Sexuality and body image issues related to cancer treatments• Treatment decision-making process among cancer survivors• Self-help group activities for chronic, life-threatening illnesses• Psychosocial issues related to infertility treatments• Multi-disciplinary collaboration in the clinical setting

Class meeting of the department

Health Promotion Sciences ——————————————————————————————————————
http://www.ethps.m.u-tokyo.ac.jp/

The main activity of the Department of Health Promotion Sciences is making health policy proposals
concerning health promotion in the community and work place through experimental and survey
research. The main research fields are health behavior and life-style related disease. The main focus ofhealth behaviors are physical activity including exercise, diet and nutrition, and obesity. Our classes
include lectures and practical training with the aim of helping
students to understand the method of planning, implementation and evaluation of the health promotion programs in thecommunity and work place.

• Development of effective health promotion programs• Assessment of the supportive environments in the community andwork place• Assessment of and supporting methods for health behavior, and theimpact on health status• Short and long term effects of behavior change• Influence of behavior change on medical costs, and cost effectiveness analysis• Determinants in the social and physical environment on the adherenceof behavior change

Physical fitness test as part of a community health promotion program43

Biomedical Ethics —————————————————————————————————————————————
http://www.ethps.m.u-tokyo.ac.jp/

The Department of Biomedical Ethics conducts both theoretical and empirical studies in the fieldsof biomedical ethics, research ethics and clinical ethics. Research topics include ethical theories,
informed consent, ethics committees and organ transplantation. The Center for Biomedical Ethics
and Law (CBEL) was recently set up as an adjunct to the Department of Biomedical Ethics.

• Study of the functions and responsibilities of ethics committees inJapan• Study of the methods for the formation of social consensus related toadvanced medical technology• Comparative study of clinical ethics in the Asian region• Publication of a medical ethics case book for Japan• Acceptability of advance directives in Japan• Development of evaluation methods for biomedical ethics education• Psychosocial and ethical aspects of living related organ transplantation

Outreach Program: CBEL provides training courses for ethics
committee members. Participants include physicians, nurses
and medical pharmaceutical representatives.

Nursing Administration / Advanced Clinical Nursing ———————————————————
http://nurs-adm.m.u-tokyo.ac.jp/

Our research programs aim to support clinical nurses in providing high quality care for theirpatients in efficient way. Under a nation-wide healthcare reform, improving the efficiency ofhealthcare delivery systems becomes essential. For nursing care, assessing the efficacy and theputting in place of quality assurance systems are required. Applying management theories to nursing administration, we focus on nursing quality improvement, nurse staffing, patient classification
systems, budgetary management, staff development and continuing education.

• Assessment and improvement of quality of nursing care
• Outcome management for nursing practice• Risk management in acute care settings• Nursing case management and critical pathways• Cost-effectiveness of nursing services• Patient classification systems• Physiological studies of clients'/caregivers' activities• Occupational safety and health of health care workers• Nursing policy and strategies to meet the professional
demands

Promoting quality nursing care

Family Nursing ———————————————————————————————————————————————
http://www.hn.m.u-tokyo.ac.jp/dept/famn/indexj.htm

Hand-in-hand with the changes occurring in society, the formation and the function of the family isalso changing. Current Japanese society expects not only client-centered perspective but also family-centered perspective from nursing research. We are especially focusing on the childrearing andchildbearing family nursing research issues.

• Late effects of treatment and posttraumatic stress disorder in children with cancer• Psychological preparation for children undergoing minor surgery• Child abuse• Care of dying children and their families• Qualitative research to explore childbearing family
formation process• Postnatal depression and difficulties in childrearing

44

Community Health Nursing —————————————————————————————————————
http://park.itc.u-tokyo.ac.jp/chn/english/index.html

Our research focuses on the development of health care programs, and establishment and evaluation of community health care systems, in response to the health care needs of individuals, families, aggregates and the communities. Also, we are performing research on standardization of skillsof public health nurses and terminology of community
health nursing.

• Establishment and evaluation of community health care systems• Around-the-clock in-home care system• Expansion of the target of visiting nurse• Hospital discharge planning• Comprehensive community care, care-networking• Development of health care programs• Support for people with diseases or disabilities• Support for families with babies and children• Elderly care
• Occupational health• Definition and standardization of skills of public health nurses/
Development of community health program• Terminology of community health nursing

Concepts of the Community Health Nursing

Adult Nursing / Palliative Care Nursing —————————————————————————————
http://www.adng.m.u-tokyo.ac.jp/indexe.htm

Mainly for subjects in their adulthood, we have been performing research in a variety of domains
including prevention of cancer and several chronic illnesses, support for coexistence with disease,and palliative care. Focal points in our research, which we conduct under a team approach, arestrategies in education and provision of relevant information based on the findings of molecularbiology, and the team-approach nursing care system.

• Care for adaptation to physical alteration after surgery• Cancer genetic counseling in nursing• Physical activity in middle- aged / elderly• Prevention and self care support for family with diabetes• Symptom management for inflammatory diseases• Evaluation of palliative care services• Spiritual care for terminally ill persons and their families• Continuity and dissemination of palliative care
• Nursing care system for out patients• Nursing terminology
Midwifery and Women's Health ——————————————————————————————————
http://park.itc.u-tokyo.ac.jp/midwifery/index1eng.htm

Having been in place since June, 2002, our research activities focus onmaternal-child health care as well as health promotion to achieve an allround good life for the well woman.

• Life style and oxidative stress during pregnancy• Maternal body composition during pregnancy and infant birth weight• Nutrition and weight management during pregnancy and postpartum• Quality of sleep and sleeping posture of women• Promotion of women's health care after delivery and during menopause• Application of the ICF (International Classification of Functioning Disability and
Health) to an assessment of quality of life among pregnant women

Photo by Sakae Kikuchi

45

Gerontological Nursing / Wound Care Management ———————————————————
http://www.rounenkango.m.u-tokyo.ac.jp/english/index-e.html

The goal of our department is "Evidence-based practice and development of Gerontological nursing/
Wound care management", where we are striving to develop new techniques, instruments, andassessment skills in accordance of nursing science and engineering and clinical nursing. We are also
involved in education and research to maintain physical ability of vulnerable elderly in community.

• Development of wound care management technique, instruments,
and assessment skills• Research of evidence based wound care
• Development of instruments to achieve the wound care management andprevention• Invention of assessment skills to manage wound care

• Development of education programs to maintain. Physical ability ofvulnerable elderly in community• Research on status of nutrition management and disuse symdrom anddevelopment of education program for the vulnerable elderly in institution and at home

46

47

International Health

Health Policy and Planning ——————————————————————————————————————
By pursuing alternative richness or happiness instead of economic growth, we would like to achieve
health through respecting existing health systems, indigenous cultures, and our nature.

• International health policy and system analysis: MDGs, IMCI, ODAs/
NGOs, Health damages and real poverty caused by globalization• Child Health: EPI, IMCI, Nutrition by Brest Feeding• Environment Health (Medical waste management and international
health policy, safety injection, aid and environmental damage)• Reproductive Health, Gender (violence)• Infectious Diseases: Malaria prevention; HIV/AIDS; Tuberculosis• Allergic Diseases and Asthma Epidemiology• Emergency Medicine

Mass vaccination campaign during National Immunization
Days for poliomyelitis eradication

International Community Health —————————————————————————————————
http://www.ich.m.u-tokyo.ac.jp/

Our Department aims at bringing together clinical, public health and social science research to address
following aspects of international health. We also conduct international cooperation activities with the
U.N., JICA, local government and NGOs in developing countries. Our educational activities provide
practical trainings for students, who are enthusiastic about contributing to research in international
health and to international cooperation.

• Health promotion in developing countries• Health and human rights• Conflicts and health• School health• Infectious diseases (HIV/AIDS, TB, Malaria etc.)• Environmental health• Health policy and its impact on health48

Human Genetics ——————————————————————————————————————————————
http://www.humgenet.m.u-tokyo.ac.jp/

Department of Human Genetics is broadly interested in the human genome diversity, especially in
the Asian populations. Specifically, we are using genomic research tools including SNP andmicrosatellite analyses, as well as gene expression profiling, to better understand the genetic background of a variety of complex diseases, especially bone and joint diseases, infectious diseases andsleep disorders.

• Theoretical and experimental analyses on the genetics of complex diseases• Development of statistical approaches for susceptibility gene mapping in complex diseases• Comprehensive genetics of bone and joint diseases• Host susceptibility factors to infectious diseases• Molecular mechanisms of sleep disorders• Development of new methodologies for genomic polymorphism and gene
expression analyses• Analysis on the genome diversity of Asia-Pacific populations• Development of methodologies for the analysis of protein interactions
Tools for genomic analyses

Developmental Medical Sciences —————————————————————————————————
Founded in 1966 as the Department of Maternal and Child Health, this department has devoted
itself to the research and education on the maintenance and promotion of mothers' and children's
health, including studies of infectious diseases, nutritional disorders and congenital anomalies. At
present, the main research activities are experimental and epidemiological studies on the etiology(genetic and environmental factors), pathogenesis, prevention and treatment of various childhood
brain disorders (congenital and acquired) that cause mental and motor disabilities and epilepsy,
from the viewpoint of international health science and developmental neuroscience.

• Studies on developmental brain disorders• Abnormal neuronal differentiation and size control (tuberous sclerosis)• Neuronal migration disorders (lissencephaly, polymicrogyria)• Perinatal brain injury (periventricular leukomalacia)• Postnatal brain injury (acute encephalopathy)• Inherited metabolic disorders (peroxisomal and mitochondrial disorders)• Molecular epidemiology of infectious diseases (diarrheal viruses)• Field studies of maternal and child health (malnutrition, obesity)• Effects of fetal malnutrition on congenital anomalies and adulthood diseases• Effects of urbanization on maternal and child health (high-rise living, childabuse, social epidemiology of infectious diseases)

Time- and space-specific expression of doublecortin,a protein regulating neuronal migration

Human Ecology ——————————————————————————————————————————————
http://www.humeco.m.u-tokyo.ac.jp/

Ecological understanding of health and survival of contemporary human populations through theanalyses of nutritional, demographic, and environmental aspects of each population is our primarygoal. Both fieldworks on various Asia-Oceania populations as well as experimental studies dealing
with nutrition and environmental chemicals are conducted, which would serves as the basis in challenging the International Health issues.

• Mechanistic analyses of the effect of subsistence transitions on the healthand environment in rural and urban communities in developing countries• Application of GPS, GIS, and remote sensing to health ecology and inter-national health• Exposure-effects evaluation of chemical pollution of watershed in rural
Indonesian children• Nutritional ecology, subsistence ecology, medical anthropology and biologicaldemography in Asia-Oceania populations• Development effects of perinatal exposures to heavy metals, pesticides, or
endocrine disrupting chemicals• Modulating effects of nutrients and nutritional status on environmental
hazardous chemicals• Genetic and environmental factors related with tolerance to infectious diseases

At a school in a survey area, West Java, Indonesia

49

Biomedical Chemistry ——————————————————————————————————————————
The aim of our department is to contribute to the overall global health and welfare through basic
research. Our current interests are: the energy metabolism of humans, parasites, and bacteria; andRNA and RNA-binding proteins.

• Human succinate dehydrogenase and mitochondrial myopathy• Ascaris suum and Caenorhabditis elegans• Molecular mechanism of adaptation to low oxygen tension• Mitochondrial quinol-fumarate reductase• C. elegans as a model system of parasitic nematodes and ageing• Malaria and Trypanosome: characterization of mitochondria as a target
for chemotherapy• Escherichia coli and Mycobacterium: respiratory enzymes and regulation of energy supply• RNA and RNA-binding proteins• Mitochondriral translation system• RNA biogenesis of Eukarya and Archaea

50

Free-living nematode Caenorhabditis elegans expressing a
recombinant green fluorescent protein inside the bodyunder the control of the promoter of the iron-sulfur subunit(Ip) gene of succinate-ubiquinone reductase (complex II)

51

1

School of Public HealthSocial and Preventive Epidemiology ———————————————————————————————
Our main research field is preventive epidemiology on lifestyle-related diseases. This department is
unique in Japan since our core research field is "nutritional epidemiology", which epidemiologicallyexamines the roles of diets for disease prevention and control.

• Methodological studies on dietary assessments• Nutritional epidemiologic studies on nutrient intakes/dietarybehaviors and health status• Studies on development of dietary promotion methods andevaluation of their effectiveness• Establishment of literature database for "epidemiologic studies ondiets and health"• Collaborative studies with clinical trial groups on nutrition-relateddiseases

Health Economics and Epidemiology Research ———————————————————————The department purports to help students become a health service practitioner with a sound theoretical and scientific ground underscored by quantitative methods of epidemiology and economics.
The department will also contribute to the society through conducting empirical assessment ofhealth practice and policy on the themes such as;• Economic assessment of medical technology• Clinical evaluation through patient-derived outcome• Standardization and management of quality of care
• Health policy assessment• Health impact of socio-economic policy

The scatter plots of financial indicators and case mix
index among Japanese acute hospitals(Research in Aid from Ministry of Health Labor andWelfare, 2006)

52

Clinical Information Engineering —————————————————————————————————
Clinical Information Engineering is a combination of information science, computer science, andclinical science designed to assist in the management and processing of data, information andknowledge to support the practice and delivery of biomedical research and clinical care.

• Medical Decision Making• Cancer informatics• Data Mining & Knowledge Discovery in Database• Virtual reality for medical science• Social information engineering for Public Health

A virtual reality application for medical decision
making53

Center for Disease Biology andIntegrative Medicine

Basic Medical Sciences (I) / Molecular Biomedicine for Pathogenesis ———————
http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

Focusing on functional analysis of newly isolated genes, particularly related to apoptosis, cell differentiation, or cell cycle, our laboratory is pursuing clarification of the pathogenesis of various diseases and the related physiological machineries in cellular and molecular aspects. Based on our
technical advantage in gene manipulation via gene knockout and transgenesis, we give high priorities to in vivo analyses. Our overall goal is to apply our findings to development of novel and definitive therapies fortypes of diseases.

• Role of AIM (Apoptosis Inhibitor of Macrophage) in atherosclerosis

development and other diseases• Regulation of hematopoiesis and its relevance to leukemogenesis; via
functional analysis of a newly identified Polycomb group molecule
MBT-1• Regulation of tumorgenesis by modulating apoptosis and cell cycle;
via analysis of DEDD-deficient animals

Basic Medical Sciences (II) / Biophysics —————————————————————————————
http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

We have been exploring two-photon excitation microscopy, which utilizes an infrared femtosecondpulsed laser as a light source, to visualize and stimulate intact tissues at the cellular and molecularlevels. We focus on the functions and disorders of the brain and secretory organs.

• The dynamics of synapses in the cerebral cortex, in relation to memory, cognitive

processes and mental disorders• Molecular mechanisms of exocytosis in synapses and the islet of Langerhans, andtheir optical control

Fine structure and function of a central
neuron studied with two-photon excitation
imaging and uncaging

54

Biomedical Materials and Systems ————————————————————————————————
http://park.itc.u-tokyo.ac.jp/tissue/ http://envchem.iis.u-tokyo.ac.jp/ http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

Ushida Lab investigates regenerated cartilage, bone and blood vessel in combination of 3D scaffold
technologies and tissue engineering. We also focus on the elucidation of cellular mechanism of signaltransduction evoked by physical stimulations such as stretching,shear and hydrostatic pressure. Sakai Lab tries to develop novel
experimental systems or devices for clinical or diagnostic applications
and those for evaluation of environmental impacts on humans basedon the approaches of chemical system engineering and on cultivationof human organ-derived cells in different scales, towards the final
goal, “human body system engineering”.

• Biodegradable polymers, bioceramics for tissue engineering• Regenerated cartilage, regenerated bone and regenerated blood vessel• Elucidation of signal transduction mechanism responding to physical stimulations• Engineering of human large internal organs• Evaluation of toxicological responses in humans using in vitro model organs• Bioassay-based environmental assessment and management
Tissue Engineering & Organ Engineering

Clinical Biotechnology —————————————————————————————————————————
http://www.bmw.t.u-tokyo.ac.jp/english/index.html http://park.itc.u-tokyo.ac.jp/NBEP/index-en.html http://square.umin.ac.jp/t-e/Nanodevices produced by nanotechnology integrate materials and systems on a nanometer scale,and hold the key to realizing the futuristic medical system that can serve the needed function at
the right time and the right place with minimal invasiveness. Furthermore, nanodevices are expected to become an important interface between basic biomedical science and clinical medicine byfacilitating the translation of basic achievements into clinical applications. Our division wishes to produce revolutionary medical nanodevices based on nanotechnology and thereby to spread the idea of“Nanomedicine” intranationally and internationally.

• Development of nano-scaled carriers of drugs and genes based on polymeric micelles• Functional diagnostic imaging• Pinpoint cancer therapy• Gene therapy• Development of functional polymeric micelles responsive to external stimuli• Development of functional cell arrays based on nano-fabrication of polymers• Development of intelligent scaffolds delivering drugs and genes and their application to regenerative medicine

Environmental Health Sciences ———————————————————————————————————
http://env-health.m.u-tokyo.ac.jp/english/index.html

The manifestation of diseases having modulation of advance brain function, endocrine system andimmune system is known to be induced not only by ‘internal environmental’ factors, but also by‘external environmental’ agents such as environmental chemicals. In order to provide scientificbasis for health risk assessment of environmental chemicals by focusing upon children's health, we
implement the mission of our division to characterize possible health effects of environmental hazardous chemicals and to clarify the toxicity mechanism with an integrative spectrum from the individual to molecular levels.

• Elucidation of the mechanism of toxicity of environmental hazardous

chemicals, such as dioxins/PCBs and heavy metals at the molecular andcellular levels• Clarification of the molecular basis of difference in susceptibility to
toxic chemicals among strains of a particular animal species as well as
among different animal species.
• Development and application of toxicity evaluation techniques at whole
body, cells and molecular levels• Development of risk assessment methodology to set up safety guidelines on the environment and food55

Research Resources and Support - Animal Research ———————————————————
http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

All researchers are accountable for paying attention to "3R" in animal experiment. We give theresearchers advice on their animal experiment plans and manage the facility of laboratory animals
so that animal experiments are carried out in consideration of animal welfare. We also teach laboratory animal science to medical undergraduates. Research activities are the development of methods
to detect trace amount of antigen and the study of interaction between host and parasite in protozoan disease.

• Histopathological diagnosis of BSE using nucleic acid signal amplification
technique• Improvement of immuno-PCR technique• Elucidation of the mechanisms that parasite escapes host immunity

Immunofluorescence stain of Golgi apparatus and tightjunction in Vero cells using nucleic acid signal amplification techniqueResearch Resources and Support - Radiation Biology ——————————————————
http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

We are investigating the molecular mechanisms of DNA double-strand break repair as the scientificbasis of radiation therapy and chemotherapy in medical oncology. We also promote the basic
research that contributes to the development of a novel therapeutic strategy by examining a link of
the DNA metabolic network including DNA replication and cell
cycle control with chromosome instability.

• Molecular mechanisms of homologous recombinational repair• Mechanisms of the choice between homologous recombination and nonhomologous end-joining• Molecular mechanisms of DNA rereplication• Mechanisms of the genesis of aneuploidy• Functional analysis of meiotic recombination genes

Centrosome fragmentation which may lead to aneuploidy

Research Resources and Support - Bioinformatics —————————————————————
http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

Targeting biomedical research support using information technologies, our division performs management of the research
network and the central servers of the Graduate School of
Medicine, and basic research of medical informatics (medical
terminology and standardization of medical vocabularies), privacy and anonymizing of personal information, security of
research network, distributed processing system for medical
information.

• Biomedical research support using network system• Standardization of medical vocabularies and coding system• Biomedical terminology and ontology• Security of biomedical research network• Privacy of personal data in medical research• Distributed processing system for medical information using the internet

56

Computer System for Biomedical Research

57

Central Clinical Facilities

Clinical Laboratory ————————————————————————————————————————————
http://lab-tky.umin.jp/

Our main duty is to provide the high-quality results of laboratory tests. We also emphasize the basic
research on laboratory automation and standardization, development and improvement of laboratory tests, and pathophysiological analyses through laboratory tests, as follows.

• Laboratory automation system• Clinical application of genetic analysis of leukemia and drug response
genes• Analysis of bioactive substances, and its application to laboratory

medicine• Analysis of the cardiac functions using ultrasound• Relationship between the respiratory function and various pathophysiological conditions• Investigation of brain function using magnetoencephalography
Laboratory automation system

Surgical Center ——————————————————————————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/syujutsu.html

Operating rooms were centralized as a surgical center for the first time in Japan, in the surgical ward building of University of Tokyo Hospital on July 1955. The surgical center moved to the new central building on
January 1988. In July 2001,the branch hospital of our university located in Mejiro was closed and joined to
our University Hospital located in Hongo. Furthermore, a new ward building was opened in October 2001.
Since then, the number of operations has been remarkably increasing. Another new central building
including new operating rooms will be constructed in fall 2006. Over 8,300 operations were performed in
the year 2006.
Teaching activities include lectures to the undergraduate and postgraduate medical students as well as
nursing staffs and medical electronics engineers, regarding aseptic techniques, sterilization methods, disinfecion methods, prevention of perioperative infections, humoral and cellular responses to trauma andshock, training of handwashing and gown techniques.

• Safety management in the operating rooms• Efficient management of the operating rooms• Cleaning, Disinfection and Sterilization• Environmental control in the operating rooms• Improvement of cost-effectiveness in the management of surgical center• Perioperative infection control• Precautions of accidental troubles in handling surgical instruments and medical devises• Development of new surgical instruments and medical devises• Three-dimensional processing of visual information
58

University hospital Medical Information Network Center (UMIN Center) ———————
http://www.umin.ac.jp/english/

UMIN is the largest and most versatile academic medical information center in the world with 270 thousands registered medical professionals and 40 million pages per view monthly web accesses.
UMIN is managed by the UMIN Council under the National
University Hospital Association.

• Major information services• Electronic Library for Biomedical Sciences (ELBIS)• Internet Data and Information Center for clinical and epidemiological research(INDICE)• Evaluation system of Postgraduate Clinical training (EPOC)• Web-based Quality Management system of Educational effectiveness (Web-QME)• Major research activities• Information systems for clinical and epidemiological research• Evaluation of medical schools and university hospitals• Library and information science• Network security

59

Pharmacy

Pharmaceutical Department —————————————————————————————————————
http://www.h.u-tokyo.ac.jp/patient/depts/yakuzai.html

Our goal is to provide optimized pharmacotherapy for each patient, based on the analysis and prediction of individual pharmacokinetics, drug sensitivity and drug adverse reaction.
We are now advancing the basic study of the regulatory mechanism of gene function and gene expression, paticularly focusing on the molecules related to osteoporosis and lifestyle diseases, as well as clinical application of genetic polymorphism analysis of drug metabolizing
enzymes and drug transporters.

• Analysis of genotype and phenotype of drug metabolizing enzymes and drugtransporters• Strategies for accurate prediction of drug disposition, and pharmacokinetic/
pharmacodynamic (PK/PD) studies• Transporters involved in lipid homeostasis• Regulatory mechanisms of signaling molecules involved in bone homeostasis
Therapentic drug monitoring

60

Center

Health Service Center ——————————————————————————————————————————
Health service center provides various annual health-checkups, health counselling and education to
the students and university staff. We also provide clinical services at our outpatient clinics. Our
search divisions are targeting elucidation of predictive factors of various diseases, presymptomatic
diagnosis of fatal diseases and mechanisms of common disorders in young adults.

• Health management• Annual health-checkups for students and the university staff• Health counseling and education• Clinical services at our outpatient clinics, including Internal Medicine,
Psychiatry etc.
• Research divisions• Genetic and MRI diagnosis of cardiovascular diseases• Genetic mechanisms of psychiatric disorders• Predictors of malignancy in the stomach• Hypertensive genes and hemodynamics in the ocular fundi• Genetic analysis of asthma• Immune responses and cardiovascular disorders• Predictors of forthcoming cognitive dysfunction in the elderly

The stepwise-determination of genetic polymorphism
responsible for cardiomyopathy

The International Research Center for Medical Education ———————————————
http://www.ircme.u-tokyo.ac.jp/

The International Research Center for Medical Education was installed as a joint educational study
institution to promote interdisciplinary research on medical education and international cooperative studies in relation to medical education. This center consists of three sections: the medical
educational international cooperation study section, the medical educational international cooperation enterprise plan coordination and information section, and the visiting professor section.

• Medical education theory / method• Medical education curriculum / technique / evaluation• Needs of medical educational international cooperation• Strategies for international cooperation in medical education• Evaluation method of international cooperation projects in medical education• Drafting, planning, and implementing international cooperation in thefield of medical education• Network formation to promote international cooperation in the field of
medical education
Prof. Snell (McGill Univ.) at her final lecture61

1

Nurce Dormitory

East ClinicalResearch Bldg

ClinicalResearchCenterInpatients' Ward B

ClinicalAmphiteater

Inpatients'
Ward ARI Bldg.

Old

Hospital Central Clinical
Service Bldg.

First
Research
Bldg.

CentralClinical Service
Bldg. 1
CentralClinical Service
Bldg. 2Administration &Research Bldg.

Tetsumon Gate

Facility Center
Bldg.
No.4

Outpatient
Clinical Bldg.

South ClinicalResearch Bldg

MedicalLibrary
International
ResearchCenter for
Medical
Education
International
ResearchCenterBldg. No.2

Center for Disease
Biology andIntegrative
Medicine
Bldg.
No.3
Experimental Research Bldg.

Bldg. No.1

Kaitokumon
Gate(Akamon Gate)

Bldg.
No.5

Kasugamon
Gate
Annex of
Bldg.
No.3

Takao Shimizu
Dean, Faculty of Medicine, Graduate School of Medicine
The University of Tokyo
Address:7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
http://www.m.u-tokyo.ac.jp

Issued on June 30, 2007