N 1881ー4980

No.50 (2021)

信 州 大 学 医 学 部 医 学 科・大 学 院 医 学 系 研 究 科・医 学 部 附 属 病 院 業 績 録

信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録

第五〇号（二〇二一）

二〇二二

2022

信大
州学
大医
学学
医部
学業
部績
業録
績編
録集要
集項
要（
項抜粋）
信州
（令和 4 年11月24日改正）

１．収録対象 ２．収録対象
信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で認めた施設等に所属する者（当該年に在籍した者全員）認めた施設等に所属する者（当該年に在籍した者全員）
２．収録内容 ３．収録内容
収録対象は、本文が欧文で執筆された研究業績とし、次の３項目に分ける。
研究業績を次の２項目に分ける。
１）論文
１）論文
原著、綜説、展望、症例報告、速報、予報で、査読のある学術雑誌に発表のもの。
原著、綜説、展望、症例報告、速報、予報で学術雑誌に発表のもの。
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をも
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をもち、ち、別刷が発行されているもの）
別刷が発行されているもの）
２）著書
２）著書
単行書、分担執筆。
単行書、分担執筆。
３）その他
治療指針、トピックス、事典等、専門的知見にもとづき執筆された、論文形式の
ただし、以下のものは除外する。
記事（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表に関するもの及び１頁ものの速報は抄録とみなす）
ただし、以下のものは除外する。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表（ハ）業務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）
に関するもの及び１頁ものの速報は抄録とみなす）（ニ）座談会記事。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（ホ）学会記。
（ハ）業務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）（ヘ）質疑応答（and ）、治療指針、問題集の解説、トピックス、話題、グラビア、（ニ）座談会記事。
事典等に類するもの。
（ホ）学会記。
（ト）新聞記事、教育に関する記事、人物紹介、書評、随筆など学術性が認められ（ヘ）論文形式をとらない質疑応答（Q and A）、問題集の解説、話題、グラビア等ないもの。
に類するもの。
（チ）著者表示が団体名で個人の著者性が認められないもの。
（ト）新聞・週刊誌記事、教育に関する記事、人物紹介、書評、随筆など学術性が（リ）学術雑誌とは認められないものに発表したもの。
認められないもの。
（ ） 本及び 論文。
（チ）著者表示が団体名で個人の著者性が認められないもの。
４．収録期間
毎年１月～12月

あ と が きあ と が き信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録第50号をお届けします。
第１号の業績録には、1972年に発表された英語論文55本（全論文339本）が掲載されておりました。それから50年の歳月が流れ、2021年に信州大学医学部から発表された英語論文数は586
信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録第 38 号をお届けします。
本と、10倍以上になりました。診療や教育で忙しい中、論文を発表された先生方の熱意、努力に敬意を表します。今回、区切りとなる第50号の業績録を担当させて頂き、大変光栄です。出
版委員会の同志であります堀内哲吉教授、福山哲広先生、北沢将人先生には、業績録に掲載可
本業績録は１年間、各講座や部門等でなされた４つの活動（研究、教育、診療、 会）
能な論文を厳格に審査して頂きました。そして医学部図書館の後閑壮登様、滝口智子様には、のうち、研究活動の成果として公表された論文を中 にまとめたものです。
、
評
事務作業で大変お世話になりました。皆様に厚く御礼申し上げます。
研究は大学の使命であり、その成果を論文として発表することは大学人の責務です。研究を、学内外への報告において、本業績録の果たすは 要と思われます。このようなから、綿密に計画してから、新たなエビデンスを得て、それを論理的思考に基づいて論文にまとめ、この１年間の研究活動を り り、今後の方 性等を考える 機にしていただけたら幸いに学術雑誌に発表するまでに、多大な労力と時間を要します。信州大学医学部から発表された英ます。
語論文数は2019年
445本、2020年 543本、2021年 586本と、年々増加しています。業績録を詳細に見ますと、誰がどのような研究を行っているか、明確に理解できます。是非本号を注意深くご覧頂き、我々の研究活動の「今と未来」を考える機会にして頂きたいです。
今年 の英文論文総数は 年 よりし、90 年 以 で最も ない 386 という 果となり現在の研究の特徴の一つとして、膨大な臨床データを用いた多施設共同研究の普及が挙げらました。しかしながら、単なる総数のみの評 がしも 切であるとは言え 、今年 の業れます。データを他施設に提供することで、研究協力者として論文に名前を連ねることができますが、そのような研究は信州大学オリジナルとは言えません。そこで本号から、コレスポン
績の中には めて質の い研究成果も なくありません。今日、 業生の大学 れや医学科入デンスオーサーにアスタリスクをつけ、論文の責任者を明示することにしました。各教室でア
学 員数増加等により、診療や教育活動等の業務は増加の一 にあります。このような現スタリスクのついた論文が毎年増えていく、そして将来の信州大学医学部を担う若手研究者・医師にアスタリスクがつくことを期待しています。
ではありますが、研究活動は大学が大学であるための大きな責務であり、外部評 基 のまた、他大学の業績録を見ますと、原著・症例報告・総説と分けて表示しているケースが多要項目であることは言うまでもありません。今後、各講座・部門等でのさらなる研究の発展をいです。研究成果は原著として発表されますので、コレスポンデンスを取っている原著論文数
祈念 します。
が、その大学の研究活動をより正確に表しているとも言えます。今後、我々の業績録でも、そのような区分けを導入したいと考えております。
さらに、各教室が現在注力している研究テーマを把握できるように、2021年から教室代表論
最後に、本業績録の 集にあたりご 力頂きました先生方、図書館 員の方々に厚く御礼申文リストを作成し、公開しています（https://www.shinshu-u.ac.jp/faculty/medicine/international/）。
し上げます。
業績録と合わせて、ご一読頂けますと幸いです。
最後に、この業績録が信州大学医学部の研究活動のさらなる活性化につながることを祈念し、あとがきとさせて頂きます。関係者の皆様、本当にありがとうございました。
英樹
田中直樹
出 版 委 員 長：英樹
出出 版版委 委員 員：
長：田中直樹山、 田文 、
知
出 版 委 員：堀内哲吉、福山哲広、北沢将人
医医学部図書館
学 部 図 書 査：
館：後閑壮登、滝口智子

第第 50 号
号
年11月
令和 25 年
月221日印刷
日印刷
年11月
令和 25 年
月221日発行日発行

発行
印刷

信州大学医学部
1

印刷

21

1

a

SCIENTIFIC ACHIEVEMENTS OFSHINSHU UNIVERSITY SCHOOL OF MEDICINE,SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE,
AND SHINSHU UNIVERSITY HOSPITAL

信州大学医学部医学科・大学院医学系研究科・
医学部 附 属 病 院 業 績 録
No. 50( 2 0 2 1 )

2022

b

1

I. Scientific Achievements of Shinshu University School of Medicine,
Shinshu University Graduate School of Medicine,and Shinshu University HospitalContents
Aging Biology ..............................................................3

Division of General Thoracic Surgery .......................20

Metabolic Regulation ...................................................3

Division of Breast and Endocrine Surgery ................21

Cardiovascular Research ..............................................3

Orthopaedic Surgery ..................................................21

Sports Medical Sciences ..............................................3

Neurosurgery ..............................................................24

Molecular Pathophysiology .........................................4

Dentistry & Oral Surgery ...........................................25

Molecular Cellular Physiology ....................................4

Urology ......................................................................26

Biochemistry and Molecular Biology ..........................4

Ophthalmology ..........................................................27

Molecular Pharmacology .............................................5

Otorhinolaryngology ..................................................27

Pathology .....................................................................5

Obstetrics and Gynecology ........................................28

Molecular and Cellular Immunology ...........................5

Anesthesiology and Resuscitology ............................28

Medical Genetics .........................................................5

Plastic and Reconstructive Surgery ...........................29

Preventive Medicine and Public Health .......................6

Laboratory Medicine ..................................................29

Legal Medicine ............................................................7

Emergency and Critical Care Medicine .....................33

Regenerative Science and Medicine ............................7

Hematology and Medical Oncology ..........................33

Medicine I

Child and Adolescent Developmental Psychiatry ......35(Respirology, Infectious Disease & Allergology) .....7
Medicine II(Gastroenterology Nephrology Hematology) ...........8
Medicine III(Neurology and Rheumatology) .............................10
Medicine IV(Diabetes,Endocrinology and Metabolism) ............12
Medicine V

Brain Disease Research ..............................................35
Innovation of Medical and Health Sciences
Research .................................................................35
Hearing Implant Sciences ..........................................36
Clinical Sequence Course ..........................................37
International Relations Office ....................................37
Radiology Division ....................................................37
Rehabilitation Center .................................................37(Cardiovascular) .....................................................12Center for Medical Genetics ......................................38

Pediatrics ....................................................................15

Shinshu Cancer Center ...............................................39

Dermatology ..............................................................16

Department of Pharmacy ...........................................39

Radiology ...................................................................17

Center for Clinical Research ......................................39

Division of Gastroenterological, Hepato-Biliary-Pancreatic,

Medical Safety Management Room ...........................39

Transplantation and Pediatric Surgery ..........................18

Division of Animal Research .....................................39

Division of Cardiovascular Surgery ...........................20

2

3

Aging Biology

Cardiovascular Research20210001
Dai J*, Li Y, Kametani F, Cui X, Igarashi
Y, Huo J, Miyahara H, Mori M, Higuchi K : Curcuminpromotes AApoAII amyloidosis and peroxisome
proliferation in mice by activating the PPARα signaling
pathway. eLife 10: e63538, 2021.

20210009
Koyama T, Kuriyama N, Suzuki Y, Saito S,
Tanaka R, Iwao M, Tanaka M, Maki T, Itoh H, Ihara M,
Shindo T, Uehara R : Mid-regional pro-adrenomedullin is
a novel biomarker for arterial stiffness as the criterion for
vascular failure in a cross-sectional study. Sci Rep 11(1):305, 2021.

20210002
Igarashi Y, Iida S, Dai J, Huo J, Cui X,
Sawashita J, Mori M, Miyahara H, Higuchi K : Glavonoidrich oil supplementation reduces stearoyl-coenzyme A
desaturase 1 expression and improves systemic metabolism
in diabetic, obese KK-Ay mice. Biomed Pharmacother 140:
111714, 2021.

Metabolic Regulation
20210003
Jia F, Hu X, Kimura T, Tanaka N* : Impact ofDietary Fat on the Progression of Liver Fibrosis: Lessons
from Animal and Cell Studies. Int J Mol Sci 22: 10303,
2021.
20210004
Aomura D, Harada M, Yamada Y, Nakajima T,
Hashimoto K, Tanaka N, Kamijo Y : Pemafibrate Protects
against Fatty Acid-Induced Nephropathy by Maintaining
Renal Fatty Acid Metabolism. Metabolites 11: 372, 2021.
20210005
Kimura T, Tanaka N, Fujimori N, Yamazaki
T, Katsuyama T, Iwashita Y, Pham J, Joshita S, Pydi SP,
Umemura T : Serum thrombospondin 2 is a novel predictor
for the severity in the patients with NAFLD. Liver Int 41:
505-514, 2021.
20210006
Kudo T, Horiuchi A, Kyodo R, Horiuchi I, AraiN, Kajiyama M, Tanaka N : Linked colour imaging versus
white-light colonoscopy for the detection of flat colorectal
lesions: A randomized controlled trial. Colorectal Dis 23:1414-1420, 2021.

20210010
Ta n a k a M , K a k i h a r a S , H i r a b a y a s h i K
Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A,
Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y,
Zhao Y, Aruga K, Yamauchi A, Murata M, Shindo T* :Adrenomedullin-Receptor Activity-Modifying Protein
2 system ameliorates subretinal fibrosis by suppressing
epithelial-mesenchymal transition in age-related maculardegeneration. Am J Pathol 191(4): 652-668, 2021.
20210011
Sakurai T*, Shindo T : Production of single- andmultiple-gene-modified mice via maternal SpCas9-based
gene editing. STAR Protoc 2(2): 100509, 2021.
20210012
Cui N, Sakurai T, Kamiyoshi A, IchikawaShindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara
S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M,
Shindo T* : Adrenomedullin-RAMP2 and -RAMP3 systems
regulate cardiac homeostasis during cardiovascular stress.
Endocrinology 162(3): 1-20, 2021.
20210013
Wei Y, Tanaka M, Sakurai T, Kamiyoshi A,
Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y,
Aruga K, Sanjo H, Shindo T* : Adrenomedullin ameliorates
pulmonary fibrosis by regulating TGF-ß-Smads Signaling
and Myofibroblast Differentiation. Endocrinology 162(8):1-22, 2021.

Sports Medical Sciences20210007
Koshu K, Ikeda T, Tamura D, Muramatsu
K, Osaka H, Ono S, Adachi K, Nanba E, Nakajima T,
Yamagata T : Gallbladder cancer with ascites in a child withmetachromatic leukodystrophy. Brain Dev 43: 140-143,
2021.

20210014
Ichihara Y, Masuki S*, Uchida K, Takahashi
K, Nakajima M, Nose H : Effects of 5-aminolevulinic acidwith iron supplementation on respiratory responses to graded
cycling and interval walking training achievement in older
women over 75 yrs. Experimental Gerontology 150: 111356,
2021.

20210008
Diao P, Jia F, Wang X, Hua X, Kimura T,
Nakajima T, Aoyama T, Moriya K, Koike K, Tanaka N* :Mechanisms of Steatosis-Derived Hepatocarcinogenesis:
L e s s o n s f r o m H C V C o r e G e n e Tr a n s g e n i c M i c e .
Engineering 7: 1797-1805, 2021.

20210015
Horiuchi M, Hasegawa T, Nose H : Effect ofCarbohydrate-Electrolyte Solution Including Bicarbonate
Ion Ad Libitum Ingestion on Urine Bicarbonate Retention
during Mountain Trekking: A Randomized, Controlled Pilot
Study. Int J Environ Res Public Health 18(4): 1441, 2021.
20210016

Nose H, Morikawa M, Furihata M, and Masuki

4

S* : High-intensity interval walking training using internetof things (IoT): past and future. J Phys Fitness Sports Med
10: 139-144, 2021.

Molecular Pathophysiology
20210017
Kakino A, Fujita Y, Ke LY, Chan HC, Tsai MH,
Dai CY, Chen CH, Sawamura T* : Adiponectin forms acomplex with atherogenic LDL and inhibits its downstream
effects. J Lipid Res 62: 100001, 2021.
20210018
Takahashi T, Huang Y, Yamamoto K, Hamano
G, Kakino A, Kang F, Imaizumi Y, Takeshita H, Nozato Y,
Nozato S, Yokoyama S, Nagasawa M, Kawai T, Takeda M,
Fujimoto T, Hongyo K, Nakagami F, Akasaka H, Takami Y,
Takeya Y, Sugimoto K, Gaisano HY, Sawamura T, Rakugi H: The endocytosis of oxidized LDL via the activation of theangiotensin II type 1 receptor. iScience 24: 102076, 2021.

T, Nohara K, Kouyama-Suzuki E, Yanagawa T, Shirai Y,
Tabuchi K* : Risperidone Mitigates Enhanced Excitatory
Neuronal Function and Repetitive Behavior Caused by an
ASD-Associated Mutation of SIK1. Front Mol Neurosci 14:
706494, 2021.
20210025
Suzuki T*, Terada N, Higashiyama S, Kametani
K, Shirai Y, Honda M, Kai T, Li W, Tabuchi K : Nonmicrotubule tubulin-based backbone and subordinate
components of postsynaptic density lattices. Life Sci
Alliance 4(7): e202000945, 2021.
20210026
Kim S, Park D, Kim J, Kim D, Kim H, Mori T,
Jung H, Lee D, Hong S, Jeon J, Tabuchi K, Cheong E, Kim
J, Um JW, Ko J : Npas4 regulates IQSEC3 expression in
hippocampal somatostatin interneurons to mediate anxietylike behavior. Cell Rep 36(3): 109417, 2021.

20210019
Yokoyama S, Kawai T, Yamamoto K, Yibin H,
Yamamoto H, Kakino A, Takeshita H, Nozato Y, Fujimoto
T, Hongyo K, Takahashi T, Nakagami F, Akasaka H, Takami
Y, Takeya Y, Sugimoto K, Sawamura T, Rakugi H : RAGE
ligands stimulate angiotensin II type I receptor (AT1) via
RAGE/AT1 complex on the cell membrane. Sci Rep 11:
5759, 2021.

20210027
Yoshida T, Yamagata A, Imai A, Kim J, Izumi
H, Nakashima S, Shiroshima T, Maeda A, IwasawaOkamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K,
Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H,
Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina
M, Mori H, Fukai S : Canonical versus non-canonicaltranssynaptic signaling of neuroligin 3 tunes development ofsociality in mice. Nat Commun 12(1): 1848, 2021.

20210020
Joshita S, Yamashita Y, Okamoto T, Usami Y,
Sugiura A, Yamazaki T, Kakino A, Ota M, Sawamura T,
Umemura T : Quantitative and qualitative lipid improvementwith chronic hepatitis C virus eradication using direct-acting
antivirals. Hepatol Res 51: 758-766, 2021.

20210028
Iizumi S, Uchida F, Nagai H, Takaoka S,
Fukuzawa S, Kanno NI, Yamagata K, Tabuchi K, Yanagawa
T, Bukawa H : MicroRNA 142-5p promotes tumor growth inoral squamous cell carcinoma via the PI3K/AKT pathway by
regulating PTEN. Heliyon 7(10): e08086, 2021.

20210021
Ohno M, Kakino A, Sekiya T, Nomura N,
Shingai M, Sawamura T, Kida H : Critical role of oxidized
LDL receptor-1 in intravascular thrombosis in a severe
influenza mouse model. Sci Rep 11: 15675, 2021.

20210029
Mehta A, Shirai Y, Kouyama-Suzuki E, Zhou
M, Yoshizawa T, Yanagawa T, Mori T, Tabuchi K* : IQSEC2
Deficiency Results in Abnormal Social Behaviors Relevant
to Autism by Affecting Functions of Neural Circuits in theMedial Prefrontal Cortex. Cells 10(10): 2724, 2021.

20210022
Ohno M, Sasaki M, Orba Y, Sekiya T, Masum
MA, Ichii O, Sawamura T, Kakino A, Suzuki Y, Kida H,
Sawa H, Shingai M : Abnormal blood coagulation andkidney damage in aged hamsters infected with severe acuterespiratory syndrome coronavirus 2. Viruses 13: 2137, 2021.

Molecular Cellular Physiology
20210023
Lai ESK, Nakayama H, Miyazaki T, Nakazawa
T, Tabuchi K, Hashimoto K, Watanabe M, Kano M :An Autism-Associated Neuroligin-3 Mutation Affects
Developmental Synapse Elimination in the Cerebellum.
Front Neural Circuits 15: 676891, 2021.
20210024

Badawi M, Mori T, Kurihara T, Yoshizawa

Biochemistry and Molecular Biology
20210030
Tomita T, Kato M, Mishima T, Matsunaga
Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H,
Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru
Y, Hiratsuka S* : Extracellular mRNA transported to
the nucleus exerts translation-independent function. Nat
Commun 12: 3655, 2021.
20210031
Tomita T, Kato M, Hiratsuka S* : Regulation ofvascular permeability in cancer metastasis . Cancer Sci 112:
2966-2974, 2021.
20210032

Ieguchi K, Tomita T, Takao T, Omori T,

5Mishima T, Shimizu I, Tognolini M, Lodola A, Tsunoda
T, Kobayashi S, Wada S, Maru Y. : Analysis of ADAM12Mediated Ephrin-A1 Cleavage and Its Biological Functions .
Int J Mol Sci 22: 2480, 2021.

Molecular Pharmacology
20210033
Cui N, Sakurai T, Kamiyoshi A, IchikawaShindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara
S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M,
Shindo T : Adrenomedullin-RAMP2 and -RAMP3 Systems
Regulate Cardiac Homeostasis during Cardiovascular Stress. Endocrinology 162(3): bqab001, 2021.

Pathology
20210034
Kobayashi M*, Matsumoto Y, Ohya M, Harada
K, Kanno H : Histologic and Immunohistochemical
Evaluation of Infiltrating Inflammatory Cells in Kawasaki
Disease Arteritis Lesions. Appl Immunohistochem Mol
Morphol 29: 62-67, 2021.
20210035
S h i g e m u r a T, M a r u y a m a Y, S h i g e t o S ,Nakazawa Y, Kanno H : Orbital Epstein-Barr virus-related
post-transplant lymphoproliferative disorder in a 13-year-old
girl with cord blood transplantation. Transpl Infect Dis 23:
e13536, 2021.
20210036
Hineno A, Oyanagi K, Yoshida T, Sakai Y,
Kanno H, Sekijima Y : Spread of vimentin-immunoreactive
cells within the plaque-like lesion in the spinal anterior
horn of a patient with post-poliomyelitis syndrome.
Neuropathology 41: 406-411, 2021.

Molecular and Cellular Immunology
20210037
Tomita T, Kato M, Mishima T, Matsunaga
Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H,
Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y,
Hiratsuka S : Extracellular mRNA transported to the nucleus
exerts translation-independent function. Nat Commun 12:
1-19, 2021.
20210038
Wei Y, Tanaka M, Sakurai T, Kamiyoshi A,
Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y,
Aruga K, Sanjo H, Shindo T : Adrenomedullin Ameliorates
Pulmonary Fibrosis by Regulating TGF-ß-Smads Signaling
and Myofibroblast Differentiation. Endocrinology 162: 1-22,
2021.

Medical Genetics
20210039

Hanafusa H, Hidaka Y, Yamaguchi T, Shimojo

H, Tsukahara T, Murase T, Matsuoka D, Chiba N, Shimada
S, Morokawa H, Omori N, Minoura H, Nagano C, Takano
K, Nakamura K, Wakui K, Fukushima Y, Uehara T,
Nakazawa Y, Iijima K, Nozu K, Kosho T* : Heterozygous
missense variant in TRPC6 in a boy with rapidly progressive
infantile nephrotic syndrome associated with diffuse
mesangial sclerosis. Am J Med Genet A 185: 2175-2179,
2021.
20210040
Minatogawa M*, Tsukahara Y, Yuzuriha S,
Kosho T* : Detailed clinical and radiological features of thefirst patient with Elsahy-Waters syndrome in East Asia . Am
J Med Genet A 185: 3909-3915, 2021.
20210041
Beck DB, Basar MA, Asmar AJ, Thompson JJ,
Oda H, Uehara DT, Saida K, Pajusalu S, Talvik I, D'Souza
P, Bodurtha J, Mu W, Barañano KW, Miyake N, Wang R,
Kempers M, Tamada T, Nishimura Y, Okada S, Kosho T,
Dale R, Mitra A, Macnamara E; Undiagnosed Diseases
Network; Matsumoto N, Inazawa J, Walkiewicz M, Õunap
K, Tifft CJ, Aksentijevich I, Kastner DL, Rocha PP, Werner
A : Linkage-specific deubiquitylation by OTUD5 defines anembryonic pathway intolerant to genomic variation . Sci Adv
7: eabe2116, 2021.
20210042
Hirose T, Mizumoto S, Hashimoto A, Takahashi
Y, Yoshizawa T, Nitahara-Kasahara Y, Takahashi N,
Nakayama J, Takehana K, Okada T, Nomura Y, Yamada
S, Kosho T*, Watanabe T : Systematic Investigation of
the Skin in Chst14-/- Mice: A Model for Skin Fragility in
Musculocontractural Ehlers-Danlos Syndrome Caused by
CHST14 Variants (mcEDS-CHST14) . Glycobiology 31:
137-150, 2021.
20210043
Ogawa A, Watanabe T, Natsume T, Okura E,
Saito S, Kato S, Nakayama Y, Furukawa S, Yamaguchi T,
Kosho T, Uehara T, Kobayashi N, Agematsu K, Nakazawa
Y, Shigemura T : Early-onset Inflammatory Bowel Disease
Caused by Mutations in the X-linked Gene IL2RG . J
Investig Allergol Clin Immunol 31: 69-71, 2021.
20210044
Ishikawa S, Kosho T, Kaminaga T, Miyamoto
M, Hamasaki Y, Yoshihara S, Hayashi S, Igawa K :Endoplasmic reticulum stress and collagenous formation
anomalies in vascular-type Ehlers-Danlos syndrome via
electron microscopy . J Dermatol 48: 481-485, 2021.
20210045
Genova F, Nonnis S, Maffioli E, Tedeschi G,
Strillacci MG, Carisetti M, Sironi G, Cupaioli FA, Di Nanni
N, Mezzelani A, Mosca E, Helps CR, Leegwater PAJ, Dorso
L; 99 Lives Consortium (including Kosho T), Longeri M :Multi-omic analyses in Abyssinian cats with primary renal
amyloid deposits . Sci Rep 11: 8339, 2021.

620210046
Uekawa K, Kaku Y, Amadatsu T, Matsuzaki
H, Ohmori Y, Kawano T, Hirata S, Yamaguchi T, Kosho T,
Mukasa A : Intracranial and extracranial multiple arterial
dissecting aneurysms in rheumatoid arthritis: A case report .
Interv Neuroradiol 27: 212-218, 2021.

20210054
Yamamoto H, Itamoto C, Yamaguchi T, Koshyo
T : Severe Hypoxemia Caused by High-Output Heart Failure
and Pulmonary Arteriovenous Malformations in Hereditary
Hemorrhagic Telangiectasia. JACC Case Rep 3: 1863-1868,
2021.

20210047
Lyons LA, Buckley RM, Harvey RJ; 99 Lives
Cat Genome Consortium (including Kosho T) : Mining
the 99 Lives Cat Genome Sequencing Consortium database
implicates genes and variants for the Ticked locus indomestic cats (Felis catus) . Anim Genet 52: 321-332, 2021.

Preventive Medicine and Public Health20210048
Yasukawa S, Uehara M, Suzuki T, Nakano M,
Kosho T, Nakamura Y, Takahashi J : The First Experienceof Denosmab Therapy on Patients with Ehlers-Danlos
Syndrome and Osteoporosis: Detailed Observation of Two
Patients. Mod Rheumatol Case Rep 5: 377-383, 2021.
20210049
Nakazawa H, Yamaguchi T, Sakai H, Maruyama
M, Kawakami T, Kawakami F, Nishina S, Ishikawa M,
Kosho T, Ishida F : A novel germline GATA2 frameshift
mutation with a premature stop codon in a family withcongenital sensory hearing loss and myelodysplastic
syndrome . Int J Hematol 114: 286-291, 2021.
20210050
Nitahara-Kasahara Y, Posadas-Herrera G,
Mizumoto S, Nakamura-Takahashi A, Inoue YU, Inoue
T, Nomura Y, Takeda S, Yamada S, Kosho T, Okada T :Myopathy Associated With Dermatan Sulfate-Deficient
Decorin and Myostatin in Musculocontractural EhlersDanlos Syndrome: A Mouse Model Investigation . Front Cell
Dev Biol 9: 695021, 2021.
20210051
Miyake N, Kosho T, Matsumoto N : Ehlers
Danlos Syndrome with Glycosaminoglycan Abnormalities .
Adv Exp Med Biol 1348: 235-249, 2021.
20210052
Hara-Isono K, Matsubara K, Hamada
R, Shimada S, Yamaguchi T, Wakui K, Miyazaki O,
Muroya K, Kurosawa K, Fukami M, Ogata T, Kosho T,
Kagami M : A patient with Silver-Russell syndrome withmultilocus imprinting disturbance, and Schimke immunoosseous dysplasia unmasked by uniparental isodisomy ofchromosome 2 . J Hum Genet 66: 1121-1126, 2021.
20210053
Nitahara-Kasahara Y, Mizumoto S, Inoue
YU, Saka S, Posadas-Herrera G, Nakamura-Takahashi A,
Takahashi Y, Hashimoto A, Konishi K, Miyata S, MasudaC, Matsumoto E, Maruoka Y, Yoshizawa T, Tanase T, Inoue
T, Yamada S, Nomura Y, Takeda S, Watanabe A, Kosho T,
Okada T : A new mouse model of Ehlers-Danlos syndrome
generated using CRISPR/Cas9-mediated genomic editing.
Dis Model Mech 14: dmm048963, 2021.

20210055
Committee for Recommendation ofO c c u p a tio n a l Ex p o s u r e Limits , J ap an Societ y for
Occupational Health, Araki A, Azuma K, Endo G, Endo Y,
Fukushima T, Hara K, Harada K, Hori H, Horie S, Horiguchi
H, Ichiba M, Ichihara G, Ishitake T, Ito A, Ito Y, Iwasawa
S, Kakamu T, Kamijima M, Karita K, Kawai T, Kawamoto
T, Kishi R, Kumagai S, Matsumoto A, Miyagawa M,
Miyauchi H, Morimoto Y, Nagano K, Naito H, Nakajima
T, Nakano M, Nomiyama T*, Okuda H, Okuda M, Omae
K, Sato K, Sobue T, Suwazono Y, Takebayashi T, Takeshita
T, Takeuchi A, Takeuchi A, Tanaka S, Tsuji M, Tsukahara
T, Ueno S, Ueyama J, Umeda Y, Yamamoto K, Yamano
Y, Yamauchi T and Yano E : Occupational exposure limits
for acetaldehyde, 2-bromopropane, glyphosate, manganeseand inorganic manganese compounds, and zinc oxide
nanoparticle, and the biological exposure indices for
cadmium and cadmium compounds and ethylbenzene, andcarcinogenicity, occupational sensitizer, and reproductive
toxicant classifications. J Occup Health 63(1): e12294, 2021.
20210056
Kurita H, Motoki N*, Inaba Y, Misawa Y,
Ohira S, Kanai M, Tsukahara T, Nomiyama T; Japan
Environment and Children’s Study (JECS) Group : Maternal
alcohol consumption and risk of offspring with congenital
malformation: the Japan Environment and Children's Study.
Pediatr Res 90(2): 479-486, 2021.
20210057
Shibazaki T, Motoki N, Misawa Y, Ohira S,
Inaba Y, Kanai M, Kurita H, Nakazawa Y, Tsukahara T,
Nomiyama T*; Japan Environment & Children’s Study(JECS) Group : Association between pesticide usage during
pregnancy and neonatal hyperbilirubinemia requiring
treatment: the Japan Environment and Children's Study.
Pediatr Res 89(6): 1565-1570, 2021.
20210058
H a s e g a w a K * , To u b o u H , Ts u k a h a r a T,
Nomiyama T : Short-Term Associations of Ambient
Fine Particulate Matter (PM2.5) with All-Cause Hospital
Admissions and Total Charges in 12 Japanese Cities. Int J
Environ Res Public Health 18(8): 4116, 2021.
20210059
Sasayama D, Kudo T, Kaneko W, Kuge R,
Koizumi N, Nomiyama T, Washizuka S, Honda H : Brief
Report: Cumulative Incidence of Autism Spectrum Disorder
Before School Entry in a Thoroughly Screened Population. J

7Autism Dev Disord 51(4): 1400-1405, 2021.

Legal Medicine
20210060
Otagiri T*, Sato N, Shiozaki T, Harayama Y,
Hayashi T, Kobayashi K, Asamura H* : Mutation analysis
for 25 Y-STR markers in Japanese population. Legal
Medicine 50: 101860, 2021.
20210061
Sato N, Shiozaki T, Otagiri T, Hayashi T,
Kobayashi K, Asamura H : A Case of Infant Suffocation due
to Incorrect Use of the Nursing Pillow. Res Pract Forens
Med 64: 183-186, 2021.

Regenerative Science and Medicine
20210062
Takemoto Y, Kadota S, Minami I, Otsuka S,
Okuda S, Abo M, Punzalan LL, Shen Y, Shiba Y*, Uesugi
M : Chemical Genetics Reveals a Role of Squalene Synthase
in TGFβ Signaling and Cardiomyogenesis. Angew Chem Int
Ed Engl 60: 21824-21831, 2021.
20210063
Kobayashi H, Ichimura H, Ohashi N, Shiba
Y* : Transplantation of Pluripotent Stem Cell-Derived
Cardiomyocytes into a Myocardial Infarction Model ofCynomolgus Monkey. Methods Mol Biol 2320: 295-302,
2021.

Medicine I(Respirology, Infectious Disease & Allergology)
20210064
Komatsu M, Yamamoto H*, Kitaguchi Y,
Kawakami S, Matsushita M, Uehara T, Kinjo T, Wada Y,
Ichiyama T, Urushihata K, Ushiki A, Yasuo M, Hanaoka M :Clinical characteristics of non-idiopathic pulmonary fibrosis,
progressive fibrosing interstitial lung diseases: A Singlecenter retrospective study . Medicine 100(13): e25322,
2021.
20210065
Nozawa S, Urushihata K*, Machida R,
Hanaoka M : The risk assessment by clinical backgroundand cephalometry for obstructive sleep apnea with CPAP
indication in Japanese . Sleep and Biological Rhythms 19:
145-154, 2021.
20210066
Koizumi T, Kanda S, Nihonmatu R, Gomi
D, Sekiguchi N, Noguchi T, Fukushima T, Kobayashi T,
Yamamoto H, Takeda T : Primary mediastinal germ celltumors- A retrospective analysis of >30 years of experiencein a single institution. Thoracic Cancer 12: 807-813, 2021.
20210067
Kawabata H, Fujimoto S, Sakai T, Yanagisawa
H, Kitawaki T, Nara K, Hagihara M, Yamamoto H :Patient’s age and d-dimer levels predict the prognosis inpatients with TAFRO syndrome. Int J Hematol 114: 179-188,
2021.
20210068
Nishie K*, Yamamoto S, Yamaga T, Horita
N, Mori R, Gouda MA, Hanaoka M : Prophylactic cranial
irradiation for extensive-stage small cell lung cancer(Protocol) . Cochrane Database of Systematic Reviews 3:
CD014559, 2021.
20210069
Urushihata K, Yunden Droma, Ito M, Hanaoka
M* : Hypoxic Ventilatory Response to Acute and Prolonged
Hypoxic Exposures in Subjects Susceptible to High-altitude
Pulmonary Edema. Shinshu Med J 69(4): 179-187, 2021.
20210070
Sonehara K, Tateishi K*, Araki T, Komatsu
M, Yamamoto H, Koizumi T, Hanaoka M : The Role of
Immune-Related Adverse Events in Prognosis and Efficacy
Prediction for Patients with Non-Small Cell Lung Cancer
Treated with Immunotherapy: A Retrospective ClinicalAnalysis. Oncology 99: 271-279, 2021.
20210071
Sonehara K, Tateishi K*, Araki T, Komatsu M,
Yamamoto H, Hanaoka M : Prognostic value of the geriatricnutritional risk index among patients with previously treatedadvanced non-small cell lung cancer who subsequently
underwent immunotherapy. Thorac Cancer 12(9): 13661372, 2021.
20210072
Kinugawa Y, Uehara T, Iwaya M, Asaka S,
Kobayashi S, Nakajima T, Komatsu M, Yasuo M, Yamamoto
H, Ota H : IL-6 expression helps distinguish Castleman's
disease from IgG4-related disease in the lung . BMC Pulm
Med 21: 219, 2021.
20210073
Akahane J, Ushiki A*, Kosaka M, Ikuyama Y,
Matsuo A, Hachiya T, Yoshiike F, Koyama S, Hanaoka M: Blood urea nitrogen-to-serum albumin ratio and A-DROP
are useful in assessing the severity of Pneumocystis
pneumonia in patients without human immunodeficiency
virus infection . J Infect Chemother 27: 707-714, 2021.
20210074
Komatsu M, Yamamoto H*, Matsui S, Terasaki
Y, Hebisawa A, Iwasawa T, Johkoh T, Baba T, Miyamoto A,
Handa T, Tomii K, Waseda Y, Bando M, Ishii H, Miyazaki
Y, Oshizawa A, Takemura T, Kawabata Y, Ogura T : Clinicalcharacteristics of immunoglobulin G4-positive interstitial
pneumonia . ERJ Open Reserch 7: 317, 2021.
20210075
Morichika D, Taniguchi A, Oda N, Fujii U,
Senoo S, Itano J, Kanehiro A, Kitaguchi Y, Yasuo M,
Hanaoka M, Satoh T, Akira S, Kiura K, Maeda Y, Miyahara
N : Loss of IL-33 enhances elastase-induced and cigarette

8smoke extract-induced emphysema in mice . Respir Res
22(1): 150, 2021.
20210076
Araki T, Tateishi K, Sonehara K, Hirota
S, Komatsu M, Yamamoto M, Kanda S, Kuraishi H,
Hanaoka M, Koizumi T : Clinical utility of the C-reactive
protein:albumin ratio in non-small cell lung cancer patientstreated with nivolumab . Thorac Cancer 12(5): 603-612,
2021.
20210077
Kawabata H, Fujimoto S, Sakai T, Yanagisawa
H, Kitawaki T, Nara K, Hagihara M, Yamamoto H, Tanimizu
M, Kato C, Origuchi T, Sunami K, Sunami Y, Masunari T,
Nakamura N, Kobayashi M, Yamagami K, Miura K, Takai
K, Aoki S, Tsukamoto N, Masaki Y : Correction to: Patient’s
age and D‑dimer levels predict the prognosis in patients withTAFRO syndrome . Int J Hematol 114: 301-302, 2021.
20210078
Kitaguchi Y*, Fujimoto K, Droma Y, Yasuo
M, Wada Y, Ueno F, Kinjo T, Kawakami S, Fukushima K,
Hanaoka M : Automated Diseased Lung Volume Percentage
Calculation in Quantitative CT Evaluation of Chronic
Obstructive Pulmonary Disease and Idiopathic Pulmonary
Fibrosis. J Comput Assist Tomogr 45: 649-658, 2021.
20210079
Araki T, Kitaguchi Y*, Suzuki Y, Komatsu M,
Sonehara K, Wada Y, Tateishi K, Hanaoka M : Prognostic
implication of erector spinae muscles in non-small-cell lungcancer patients treated with immuno-oncology combinatorial
chemotherapy . Thorac Cancer 12: 2857-2864, 2021.
20210080
Goto N, Wada Y*, Ikuyama Y, Akahane J,
Kosaka M, Ushiki A, Kitaguchi Y, Yasuo M, Yamamoto H,
Matsuo A, Hachiya T, Ideura G, Yamazaki Y, Hanaoka M :The usefulness of a combination of age, body mass index,
and blood urea nitrogen as prognostic factors in predicting
oxygen requirements in patients with coronavirus disease2019 . J Infect Chemother 27(12): 1706-1712, 2021.
20210081
Nishina S, Sakai H, Kawakami T, Kanai S,
Ushiki A, Natori T, Igarashi Y, Mitarai S, Yoshiyama T,
Ishida F, Nakazawa H : Isolated splenic Mycobacterium
tuberculosis complex infection in an immunocompetent
individual with FDG-PET positive mass. J Infect Chemother27: 354-358, 2021.
20210082
Sonehara K, Tateishi K*, Hirabayashi T, Araki
T, Ikuyama Y, Machida R, Hanaoka M : A Case of Lung
Adenocarcinoma with Long-Term Response after Late-Onset
Pembrolizumab-Induced Acute Adrenal Insufficiency. Case
Rep Oncol 14: 1-7, 2021.
20210083

Araki T*, Kobayashi T, Kobayashi S, Sonehara

K, Tateishi K, Kanda S, Hanaoka M, Koizumi T : Thymic
epithelial tumor with superior vena cava syndrome
diagnosed by percutaneous endovascular tumor biopsy: A
report of two cases. Respir Investig 59(5): 695-699, 2021.
20210084
Sonehara K*, Araki T, Hanaoka M : Rothia
aeria pneumonia in an immunocompetent patient: A novel
case study. Respirol Case Rep 9: e0843, 2021.
20210085
Sonehara K, Tateishi K*, Araki T, Komatsu M,
Akahane J, Yamamoto H, Hanaoka M : PembrolizumabInduced Adrenal Insufficiency in Patients with Untreated
Advanced Non-Small Cell Lung Cancer: A Case Series.
Case Rep Oncol 14: 1561-1566, 2021.

Medicine II(Gastroenterology Nephrology Hematology)
20210086
Aomura D, Harada M, Yamada Y, Nakajima T,
Hashimoto K, Tanaka N, Kamijo Y* : Pemafibrate Protects
against Fatty Acid-Induced Nephropathy by Maintaining
Renal Fatty Acid Metabolism. Metabolites 11: 372, 2021.
20210087
Aomura D, Yamada Y*, Harada M, Hashimoto
K, Kamijo Y : Hospital Admission to a Window-Side Bed
Does Not Prevent Delirium: A Retrospective Cohort Studyof Older Medical Inpatients in General Wards. Front Med 8:744581, 2021.
20210088
Barella LF, Jain S, Kimura T, Pydi SP :Metabolic roles of G protein-coupled receptor signaling inobesity and type 2 diabetes. FEBS J 288: 2622-2644, 2021.
20210089
Enomoto M, Umemura T, Suzuki F : I shall be
released (from infinite HBV nucleos(t)ide analog therapy):
Japanese experience. J Hepatol 75: 1496-1497, 2021.
20210090
Hashimoto K, Kamijo Y, Harada M, Yamada Y,
Kanno T, Kanno Y* : Impact of a change in vascular accessflow volume after percutaneous transluminal angioplasty on
cardiac function. Sci Prog 104: 368504211031097, 2021.
20210091
Ikeda H, Inoue H, Abad MRA, Fujiyoshi
Y, Nishikawa Y, Toshimori A, Tanabe M, Shimamura Y,
Sumi K, Iwaya Y, Manolakis A, Onimaru M : Diagnosis ofcongenital esophageal stenosis in adults and treatment withperoral endoscopic myotomy. Ann Gastroenterol 34: 493500, 2021.
20210092
Iwaya M, Hayashi H, Nakajima T, Matsuda K,
Kinugawa Y, Tobe Y, Tateishi Y, Iwaya Y, Uehara T, Ota H: Colitis-associated colorectal adenocarcinomas frequently
express claudin 18 isoform 2: implications for claudin 18.2

9

monoclonal antibody therapy. Histopathology 79: 227-237,
2021.
20210093
Jia F, Hu X, Kimura T, Tanaka N : Impact ofDietary Fat on the Progression of Liver Fibrosis: Lessons
from Animal and Cell Studies. Int J Mol Sci 22: 10303,
2021.
20210094
Joshita S*, Ota M, Kobayashi H, Wakabayashi
SI, Yamashita Y, Sugiura A, Yamazaki T, Tanaka E,
Umemura T : Association analysis of KIR/HLA genotype
with liver cirrhosis, hepatocellular carcinoma, and NUC
freedom in chronic hepatitis B patients. Sci Rep 11: 21424,
2021.
20210095
Joshita S*, Yamashita Y, Okamoto T, Usami
Y, Sugiura A, Yamazaki T, Kakino A, Ota M, Sawamura T,
Umemura T : Quantitative and qualitative lipid improvementwith chronic hepatitis C virus eradication using direct-acting
antivirals. Hepatol Res 51: 758-766, 2021.
20210096
Kako S, Iwaya Y*, Nagaya T, Hara D, Okamura
T, Iwaya M, Kurasawa S, Kato S, Nakayama Y, Akamatsu
T, Umemura T : Clinicopathological features of nodular
gastritis in three classes of age. Helicobacter 26: e12845,
2021.
20210097
Kako S, Iwaya Y*, Nagaya T, Umemura T :Successful treatment of gallstone ileus with double-balloon
enteroscopy-assisted electrohydraulic lithotripsy. Dig Liver
Dis 53: 498-499, 2021.
20210098
Kimura T*, Singh S, Tanaka N, Umemura T: Role of G Protein-Coupled Receptors in Hepatic Stellate
Cells and Approaches to Anti-Fibrotic Treatment of NonAlcoholic Fatty Liver Disease. Front Endocrinol 12:773432, 2021.
20210099
Kimura T*, Tanaka N, Fujimori N, Yamazaki
T, Katsuyama T, Iwashita Y, Pham J, Joshita S, Pydi SP,
Umemura T : Serum thrombospondin 2 is a novel predictor
for the severity in the patients with NAFLD. Liver Int 41:
505-514, 2021.
20210100
Kobayashi H, Joshita S*, Akahane Y, Matsuzaki
K, Yamada H, Aomura D, Joshita N, Midorikawa H, Suyama
K, Ota M, Wakabayashi SI, Yamashita Y, Sugiura A,
Yamazaki T, Misawa H, Umemura T : Protocol: Prospective
observational study aiming for micro-elimination of hepatitis
C virus in Nagawa town: The Nagawa Project. PLoS One
16: e0256711, 2021.
20210101

Kobayashi H, Joshita S*, Nozawa Y, Tanaka

T, Hashigami K, Suganuma T, Takahashi T, Nakamura Y,
Ogiwara H, Sano K, Umemura T : Intestinal Obstruction
Due to Mesenteric Inflammatory Veno-occlusive Disease: A
Case Report and Summary of the Literature. Shinshu Med J
69: 141-147, 2021.
20210102
Koyama M, Yamazaki T*, Joshita S, Ito A, Ono
K, Watanabe T, Yamashita Y, Sugiura A, Kobayashi M, Sato
Y, Takahashi M, Okamoto H, Umemura T : An Autopsy Caseof Primary Biliary Cholangitis with Histological Submassive
Hepatic Necrosis Caused by Acute Hepatitis E Virus
Infection. Intern Med 60: 1863-1870, 2021.
20210103
Kuraishi Y, Uehara T, Muraki T, Iwaya M,
Kinugawa Y, Nakajima T, Watanabe T, Miyagawa Y,
Umemura T : Impact of DNA double-strand breaks onpancreaticobiliary maljunction carcinogenesis. Diagn Pathol
16: 72, 2021.
20210104
Ogawa Y, Harada M, Hashimoto K, Kamijo Y* :Prevalence of latent tuberculosis infection and its risk factors
in Japanese hemodialysis patients. Clin Exp Nephrol 25:1255-1265, 2021.
20210105
Okada R, Furusawa A, Vermeer DW, Inagaki F,
Wakiyama H, Kato T, Nagaya T, Choyke PL, Spanos WC,
Allen CT, Kobayashi H : Near-infrared photoimmunotherapy
targeting human-EGFR in a mouse tumor model simulating
current and future clinical trials. EBioMedicine 67: 103345,
2021.
20210106
Shimamura Y, Inoue H, Rodriguez de Santiago
E, Abad MRA, Fujiyoshi Y, Toshimori A, Tanabe M, Sumi
K, Iwaya Y, Ikeda H, Onimaru M : Characterization of
intragastric pressure waveform in endoscopic pressure
study integrated system: Novel diagnostic device forgastroesophageal reflux disease. Dig Endosc 33: 780-787,
2021.
20210107
Shimamura Y, Inoue H, Rodriguez de Santiago
E, Abad MRA, Fujiyoshi Y, Toshimori A, Tanabe M, Sumi
K, Iwaya Y, Ikeda H, Onimaru M, Kushima M, Goda K: Diagnostic yield of fourth-generation endocytoscopy
for esophageal squamous lesions using a modified
endocytoscopic classification. Dig Endosc 33: 1093-1100,
2021.
20210108S h i m a m u r a Y, I w a y a Y, K o b a y a s h i R ,Rodriguez de Santiago E, Muwanwella N, Raftopoulos
S, Mosko JD, May GR, Kandel G, Kortan P, Marcon N,
Teshima CW : Clinical and pathological predictors offailure of endoscopic therapy for Barrett's related highgrade dysplasia and early esophageal adenocarcinoma. Surg

10

Endosc 35: 5468-5479, 2021.
20210109
Sumi K, Inoue H, Kobayashi Y, Iwaya Y,
Abad MRA, Fujiyoshi Y, Shimamura Y, Ikeda H, Onimaru
M : Endoscopic treatment of proton pump inhibitorrefractory gastroesophageal reflux disease with anti-reflux
mucosectomy: Experience of 109 cases. Dig Endosc 33:
347-354, 2021.
20210110
Ta n a k a N , M u k a i y a m a K , M o r i k a w a A ,Kawakami S, Ichise Y, Kimura T, Horiuchi A : Pemafibrate,a novel selective PPARalpha modulator, attenuatestamoxifen-induced fatty liver disease. Clin J Gastroenterol
14: 846-851, 2021.
20210111
Tsuchiya T, Iwaya Y*, Iwaya M, Okamura T,
Nagaya T, Umemura T : A Case of Multiple Perineuriomas
in the Colon With Underlying Neurofibromatosis Type I.
ACG Case Rep J 8: e00665, 2021.
20210112
Umemura T*, Joshita S, Saito H, Wakabayashi
SI, Kobayashi H, Yamashita Y, Sugiura A, Yamazaki T,
Ota M : Investigation of the Effect of KIR-HLA Pairs on
Hepatocellular Carcinoma in Hepatitis C Virus Cirrhotic
Patients. Cancers (Basel) 13: 3267, 2021.
20210113
Wakabayashi SI, Joshita S*, Kimura K, Motoki
H, Kobayashi H, Yamashita Y, Sugiura A, Yamazaki
T, Kuwahara K, Umemura T : Protocol: Prospective
observational study investigating the prevalence and clinicaloutcome of portopulmonary hypertension in Japanesepatients with chronic liver disease. PLoS One 16: e0249435,
2021.

hepatocellular carcinoma occurrence and incidence-free rate
after a sustained virologic response in chronic hepatitis C.
Hepatol Res 51: 933-942, 2021.
20210117
Yamazaki T*, Joshita S, Ichijo T, Kobayashi
H, Wakabayashi SI, Yamashita Y, Sugiura A, Kawakami
F, Nakazawa H, Umemura T : Successful treatment byglecaprevir/pibrentasvir followed by hepatoprotective
therapy of acute chronic hepatitis exacerbation caused bydaratumumab-based regimen for multiple myeloma: Case
report and review of the literature. J Infect Chemother 27:
1750-1755, 2021.

Medicine III(Neurology and Rheumatology)
20210118
Abe R, Katoh N*, Takahashi Y, Takasone
K, Yoshinaga T, Yazaki M, Kametani F, Sekijima Y :Distribution of amyloidosis subtypes based on tissue biopsy
site - Consecutive analysis of 729 patients at a single
amyloidosis center in Japan. Pathol Int 71: 70-79, 2021.
20210119
Aono Y, Hamatani Y, Katoh N, Nakagawa M,
Nakamura K, Yazaki M, Kametani F, Iguchi M, Murakami
I, Ogawa H, Abe M, Akao M, Sekijima Y* : Late-onset
Hereditary ATTR Amyloidosis with a Novel p.P63S (P43S)
Transthyretin Variant. Intern Med 60: 557-561, 2021.
20210120
Fujiya T, Hatta W, Koike T, Ogata Y, Saito M,
Jin X, Nakagawa K, Kanno T, Asanuma K, Uno K, Asano N,
Imatani A, Fujishima F, Katoh N, Yoshinaga T, Masamune A: A Rare Case of Localized Esophageal Amyloidosis. Intern
Med 60: 1529-1532, 2021.

20210114
Yamada Y*, Harada M, Hara Y, Iwabuchi R,
Hashimoto K, Yamamoto S, Kamijo Y : Efficacy of plasma
exchange for antineutrophil cytoplasmic antibody-associatedsystemic vasculitis: a systematic review and meta-analysis.
Arthritis Res Ther 23: 28, 2021.

20210121
Garcia-Pavia P, Bengel F, Brito D, Damy T,
Duca F, Dorbala S, Nativi-Nicolau J, Obici L, Rapezzi C,
Sekijima Y, Elliott PM : Expert consensus on the monitoringof transthyretin amyloid cardiomyopathy. Eur J Heart Fail
23: 895-905, 2021.

20210115
Ya m a s h i t a Y, J o s h i t a S * , K o b a y a s h i H ,Wakabayashi SI, Sugiura A, Yamazaki T, Umemura T :Primary Hepatic Extranodal Marginal Zone Lymphomaof Mucosa-Associated Lymphoid Tissue in a Patient with
Chronic Hepatitis B Virus Infection: Case Report andSummary of the Literature. Medicina (Kaunas) 57: 280,
2021.

20210122
Hanafusa H, Hidaka Y, Yamaguchi T, Shimojo
H, Tsukahara T, Murase T, Matsuoka D, Chiba N, Shimada
S, Morokawa H, Omori N, Minoura H, Nagano C, Takano
K, Nakamura K, Wakui K, Fukushima Y, Uehara T,
Nakazawa Y, Iijima K, Nozu K, Kosho T : Heterozygous
missense variant in TRPC6 in a boy with rapidly progressive
infantile nephrotic syndrome associated with diffuse
mesangial sclerosis. Am J Med Genet A 185: 2175-2179,
2021.

20210116
Yamashita Y, Joshita S*, Sugiura A, Yamazaki
T, Kobayashi H, Wakabayashi SI, Yamada Y, Shibata S,
Kunimoto H, Iwadare T, Matsumura M, Miyabayashi C,
Okumura T, Ozawa S, Nozawa Y, Kobayashi N, Komatsu M,
Fujimori N, Saito H, Umemura T : aMAP score prediction of

20210123
Hayashida A, Li Y, Yoshino H, Daida K, Ikeda
A, Ogaki K, Fuse A, Mori A, Takanashi M, Nakahara T,
Yoritaka A, Tomizawa Y, Furukawa Y, Kanai K, Nakayama

11Y, Ito H, Ogino M, Hattori Y, Hattori T, Ichinose Y,
Takiyama Y, Saito T, Kimura T, Aizawa H, Shoji H, Mizuno
Y, Matsushita T, Sato M, Sekijima Y, Morita M, Iwasaki
A, Kusaka H, Tada M, Tanaka F, Sakiyama Y, Fujimoto
T, Nagara Y, Kashihara K, Todo H, Nakao K, Tsuruta K,
Yoshikawa M, Hara H, Yokote H, Murase N, Nakamagoe K,
Tamaoka A, Takamiya M, Morimoto N, Nokura K, Kako T,
Funayama M, Nishioka K, Hattori N : The identified clinicalfeatures of Parkinson's disease in homo-, heterozygous anddigenic variants of PINK1. Neurobiol Aging 97: 146.e1-146.
e13, 2021.
20210124
Hineno A,Ikeda SI : A Long-Term Observationon the Possible Adverse Effects in Japanese Adolescent Girls
after Human Papillomavirus Vaccination. Vaccines 9: 856,
2021.
20210125
Hineno A, Oyanagi K, Yoshida T, Sakai Y,
Kanno H, Sekijima Y : Spread of vimentin-immunoreactive
cells within the plaque-like lesion in the spinal anterior
horn of a patient with post-poliomyelitis syndrome.
Neuropathology 41: 406-411, 2021.
20210126I c h i k a w a T, S h i m o j i m a Y * , K i s h i d a
D , K a n e k o T, S e k i j i m a Y : P r i m a r y c e n t r a lnervous system lymphoma in neuropsychiatricsystemic lupus erythematosus: case‑based review.
Rheumatol Int 41: 1009-1017, 2021.

20210131
Koyama S, Sekijima Y*, Ogura M, Hori M,
Matsuki K, Miida T, Harada-Shiba M : Cerebrotendinous
Xanthomatosis: Molecular Pathogenesis, Clinical Spectrum,
Diagnosis, and Disease-Modifying Treatments. J Atheroscler
Thromb 28: 905-925, 2021.
20210132
Kuroha M, Yoshinaga T, Yazaki M, Fujishima
F, Handa T, Suzuki K, Hishinuma K, Masu Y, Shimoyama
Y, Naito T, Moroi R, Kanazawa Y, Shiga H, Kakuta Y,
Masamune A : Localized intestinal AL amyloidosis detected
as bright green using autofluorescence endoscopy. Clin J
Gastroenterol 14: 815-819, 2021.
20210133
Miyawaki Y, Shimizu S, Ogawa Y, Sada KE,
Katayama Y, Asano Y, Hayashi K, Yamamura Y, HiramatsuAsano S, Ohashi K, Morishita M, Watanabe H, TakanoNarazaki M, Matsumoto Y, Yajima N, Yoshimi R, Shimojima
Y, Ohno S, Kajiyama H, Ichinose K, Sato S, Fujiwara M,
Yamazaki H, Yamamoto Y, Wada J, Fukuhara S : Associationof glucocorticoid doses and emotional health in lupus low
disease activity state (LLDAS): a cross-sectional study.
Arthritis Res Ther 23: 79, 2021.
20210134
Mizuno H, Hoshino J, So M, Kogure Y, Fujii
T, Ubara Y, Takaichi K, Nakaniwa T, Tanaka H, Kurisu
G, Kametani F, Nakagawa M, Yoshinaga T, Sekijima Y,
Higuchi K, Goto Y, Yazaki M : Dialysis-related amyloidosis
associated with a novel β2-microglobulin variant. Amyloid
28: 42-49, 2021.

20210127
Ichikawa T, Shimojima Y*, Kishida D, Ueno
KI, Sekijima Y : The implication of interferon-gammaproducing immunocompetent cells for evaluating diseaseactivity and severity in adult-onset Still's disease. Int J
Rheum Dis 24: 1176-1185, 2021.

20210135
Morisaki S, Tsuchida S, Konishi E, Katoh N,
Takahashi Y, Takahashi K : Localized Immunoglobulin
Light-Chain Amyloidosis of the Ulnar Nerve. Case Rep
Neurol 13: 305-311, 2021.

20210128
Ichimata S, Katoh N*, Abe R, Yoshinaga T,
Kametani F, Yazaki M, Uehara T, Sekijima Y : A case ofnovel amyloidosis: glucagon-derived amyloid deposition
associated with pancreatic neuroendocrine tumour. Amyloid
28: 72-73, 2021.

20210136
Nakagawa M, Yazaki M, Kametani F, Katoh
N, Yoshinaga T, Higuchi K, Sekijima Y : Development
of diagnostic antibodies against immunoglobulin heavy
chain variable region for heavy chain amyloidosis (AHamyloidosis). Pathol Int 71: 245-254, 2021.

20210129
Kinoshita M, Oyanagi K, Kondo Y, Ishizawa
K, Ishihara K, Yoshida M, Inoue T, Mitsuyama Y, Yoshida
K, Yamada M, Sekijima Y, Ikeda SI : Pathologic basis of thepreferential thinning of thecorpus callosum in adult-onset
leukoencephalopathy with axonal spheroids and pigmented
glia (ALSP). eNeurologicalSci 22: 100310, 2021.

20210137
Nomura S, Shimojima Y*, Yoshizawa E,
Kondo Y, Kishida D, Sekijima Y : Mesenteric panniculitis
in systemic lupus erythematosus showing characteristic
computed tomography findings. Lupus 30: 1358-1359, 2021.

20210130
K i s h i d a D , U s h i y a m a S , S h i m o j i m a Y,
Ueno KI, Kurashina JI, Shirai T, Sekijima Y : PainlessPanniculitis upon the Treatment of Clinically Amyopathic
Dermatomyositis with Anti-MDA5 Antibody. Intern Med
60: 2697-2700, 2021.

20210138
Sagawa T, Kogiso T, Ito T, Yasuda H, Katoh N,
Yoshinaga T, Yazaki M, Kato T, Omori A, Kotera Y, Egawa
H, Yamamoto M, Tokushige K : Hereditary Apolipoprotein
A-1 Amyloidosis With Glu34Lys Mutation Treated by Liver
Transplantation: A Case Report. Transplant Proc 53: 13271332, 2021.

1220210139
S h i m o j i m a Y * , I c h i k a w a T, K i s h i d a D ,Takamatsu R, Sekijima Y : Circulating regulatory T cells in
adult-onset Still's disease: Focusing on their plasticity andstability. Clin Exp Immunol 206: 184-195, 2021.
20210140S h i m o j i m a Y * , K i s h i d a D , I c h i k a w a T,
Takamatsu R, Nomura S, Sekijima Y : Oxidative Stress
Promotes Instability of Regulatory T Cells in Antineutrophil
Cytoplasmic Antibody-Associated Vasculitis. Front Immunol
12: 789740, 2021.
20210141
Takahashi Y, Hatta W, Koike T, Ogata Y, Fujiya
T, Saito M, Jin X, Nakagawa K, Kanno T, Asanuma K, Uno
K, Asano N, Imatani A, Fujishima F, Katoh N, Yoshinaga T,
Masamune A : Localized Gastric Amyloidosis that Displayed
Morphological Changes over 10 Years of Observation. Intern
Med 60: 539-543, 2021.
20210142
Tsuda R, Shinoda K, Ushijima R, Nakamura M,
Katoh N, Imura J, Tobe K : A case of wild-type transthyretin
cardiac amyloidosis with rheumatoid arthritis. Mod
Rheumatol Case Rep 5: 206-213, 2021.
20210143
Waddington-Cruz M, Ando Y, Amass L,
Kiszko J, Chapman D, Sekijima Y, THAOS investigators :Feasibility of assessing progression of transthyretin amyloid
polyneuropathy using nerve conduction studies: Findings
from the Transthyretin Amyloidosis Outcomes Survey(THAOS). J Peripher Nerv Syst 26: 160-166, 2021.
20210144
Yanagisawa S, Takahashi Y, Sasaki J, Takasone
K, Yoshie K, koyama J,Katoh N, Yazaki M, Kuwahara K,
Sekijima Y* : Absolute quantitative analysis of cardiac
amyloidosis using SPECT/CT with 99mTc-pyrophosphate.
Amyloid 28: 213-214, 2021.
20210145
Yoshinaga T, Katoh N, Yazaki M, Sato M,
Kametani F, Yasuda H, Watanabe K, Kawata K, Nakagawa
M, Sekijima Y : Giant hepatomegaly with splenotesticular enlargement in a patient with apolipoprotein A-I
amyloidosis: an uncommon type of amyloidosis in Japan.
Intern Med 60: 575-581, 2021.

Medicine IV(Diabetes,Endocrinology and Metabolism)
20210146
Komatsu M*, Ekelund M, Horio H, Kadowaki
T : Efficacy and safety of fast-acting insulin aspart comparedwith insulin aspart in combination with insulin degludec inJapanese adults with type 1 diabetes: a subgroup analysis of
the randomized onset 8 trial . Endocr J 68: 429-440, 2021.
20210147

Komatsu M*, Watada H, Kaneko S, Ross Agner

BF, Nishida T, Kaku KJ : Efficacy and safety of the fixedratio combination of insulin degludec and liraglutide bybaseline glycated hemoglobin, body mass index and age
in Japanese individuals with type 2 diabetes: A subgroup
analysis of two phase III trials . J Diabetes Investig 12:
1610-1618, 2021.
20210148
Sekido K, Sekido T, Ohkubo Y, Shibata Y,
Kawata I, Yamaguchi T, Sato A, Sato Y, Komatsu M* :Exploring hidden atrial fibrillation in patients with type 2
diabetes mellitus admitted to Shinshu University Hospital.
Shinshu Med J 69: 75-81, 2021.
20210149
Shibata Y, Yamazaki M*, Kitahara J, Okubo
Y, Oiwa A, Sato A, Komatsu M : Changes in serum uricacid levels as a predictor of future decline in renal function
in older adults with type 2 diabetes . Medicine (Baltimore)
100: e27420, 2021.
20210150
Matsushita R, Sakurai A, Minamitani K,
Yamazaki M, Uchino S : Extra-endocrine phenotypes atinfancy in multiple endocrine neoplasia type 2B: A caseseries of six Japanese patients . Clin Pediatr Endocrinol 30:
195-200, 2021.
20210151
Asano Y, Koshi T, Sano A, Maruno T, Kosaka
M, Yamazaki Y, Oiwa A*, Nishii Y : A patient with mild
respiratory COVID-19 infection who developed bilateral
non-hemorrhagic adrenal infarction . Nagoya J Med Sci 83:
883-891, 2021.

Medicine V(Cardiovascular)
20210152
Okada A, Shoda M*, Tabata H, Kobayashi H,
Shoin W, Okano T, Yoshie K, Kato K, Motoki H, Kuwahara
K : Simultaneous infection of abandoned leads and newly
implanted leadless cardiac pacemaker: Why did this occur?.
J Cardiol Cases 23: 35-37, 2021.
20210153
Maruyama S, Ebisawa S, Miura T, Yui H,
Kashiwagi D, Nagae A, Sakai T, Kato T, Saigusa T, Okada
A, Motoki H, Kuwahara K : Impact of nutritional index on
long‑term outcomes of elderly patients with coronary arterydisease: sub‑analysis of the SHINANO 5 year registry. Heart
Vessels 36: 7-13, 2021.
20210154
Kinoshita H, Aoki T, Motoki H, Wakita T,
Onishi Y, Watanabe-Fujinuma E, Kuwahara K : Patient
Journey and Disease-Related Burden in Japanese Patients
With Chronic Thromboembolic Pulmonary Hypertension: A
Mixed Methods Study. Value Health Reg Issues 24: 17-23,
2021.

13

20210155
Tabata H, Okada A, Kobayashi H, Shoin W,
Okano T, Yoshie K, Motoki H, Shoda M, Kuwahara K :“Alpha”-Looped Broken Pacemaker Lead Inside the Heart.
Circ J 85: 77, 2021.
20210156
Kobayashi H, Tabata H, Shoin W, Okano T,
Yoshie K, Okada A*, Shoda M*, Kuwahara K : A case oftransient ventricular pre-excitation associated with takotsubo
cardiomyopathy. J Electrocardiol 65: 73-75, 2021.
20210157
Kashiwagi D, Ebisawa S, Yui H, Maruyama S,
Nagae A, Sakai T, Kato T, Saigusa T, Okada A, Motoki H,
Kuwahara K : Prognostic usefulness of residual SYNTAX
score combined with clinical factors for patients with acutecoronary syndrome who underwent percutaneous coronary
intervention from the SHINANO Registry. Heart Vessels 36:
170-179, 2021.
20210158
Okada A, Kato K, Shoda M*, Tabata H, Yoshie
K, Kuwahara K : Successful catheter ablation of atrial
tachycardia in cor triatriatum sinister: A figure of eight
reentry in the left atrial membrane. HeartRhythm Case Rep
7: 109-111, 2021.
20210159
Nomoto F, Suzuki S, Hashizume N, Kanzaki
Y, Maruyama T, Kozuka A, Saigusa T, Ebisawa S, Okada
A, Motoki H, Yahikozawa K, Kuwahara K : A case of
Dressler’s syndrome successfully treated with colchicine andacetaminophen. J Cardiol Cases 23: 131-135, 2021.
20210160
Okada A, Tabata H, Shoda M*, Shoin W,
Kobayashi H, Okano T, Yoshie K, Kato K, Saigusa T,
Ebisawa S, Motoki H, Kuwahara K : Safe and effective
transvenous lead extraction for elderly patients utilizing nonlaser and laser tools: A single-center experience in Japan.
Heart Vessels 36: 882-889, 2021.
20210161
Kuwahara K : The natriuretic peptide systemin heart failure: Diagnostic and therapeutic implications.
Pharmacol Ther 227: 107863, 2021.
20210162
Harada M*, Motoki H, Sakai T, Kuwahara K: Granulocyte colony stimulating factor-associated aortitis
evaluated via multiple imaging modalities including vascularechography:a case report. Eur Heart J Case Rep 5: ytaa503,
2021.
20210163
Otagiri K, Machida K, Itagaki T, Takeuchi
T, Tsujinaka Y, Yui H, Nakamura C, Sakai T, Kato T,
Saigusa T, Ebisawa S, Motoki H, Kuwahara K, Kitabayashi
H : Predictive Value of Abdominal Fat Distribution on
Coronary Artery Disease Severity Stratified by Computed
Tomography-Derived SYNTAX Score. Am J Cardiol 150:

32-39, 2021.
20210164
Uchida M, Kashima Y, Mochizuki K, Sakamoto
H, Mori K, Ebisawa S, Takeshige K, Nitta K, Kuwahara
K, Imamura H : Multisystem Inflammatory Syndrome inChildren - A New Syndrome Complicated With Acute Heart
Failure Following Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2) Infectio. Circ J 85: 948-952,
2021.
20210165
Higuchi S, Okada A, Shoda M*, Yagishita D,
Saito S, Kanai M, Kataoka S,Yazaki K, Tabata H, Kobayashi
H, Shoin W, Okano T, Yoshie K, Ejima K, Kuwahara K,
Hagiwara N : Leadless cardiac pacemaker implantations
after infected pacemaker system removals in octogenarians.
J Geriatr Cardiol 18: 505-513, 2021.
20210166
Fuchida A, Suzuki S, Motoki H, Kanzaki Y,
Maruyama T, Hashizume N, Kozuka A, Yahikozawa K,
Kuwahara K : Prognostic significance of diastolic bloodpressure in patients with heart failure with preserved ejection
fraction. Heart Vessels 36: 1159-1165, 2021.
20210167
Yoshie K, Okada A, Shoda M, Kuwahara
K : Unique Atrial Tachycardia From the Right Inferior
Pulmonary Vein Mimicking Multiple Focal Patterns in the
Bilateral Atria and Aorta. Circ Rep 3: 472-473, 2021.
20210168
Kobayashi H, Ichimura H, Ohashi N, Shiba
Y : Transplantation of Pluripotent Stem Cell-Derived
Cardiomyocytes into a Myocardial Infarction Model ofCynomolgus Monkey. Methods Mol Bio 2320: 295-302,
2021.
20210169
Shiba M, Kato T, Morimoto T, Yaku H, Inuzuka
Y, Tamaki Y, Ozasa N, Seko Y, Yamamoto E, Yoshikawa
Y, Kitai T, Yamashita Y, Iguchi M, Nagao K, Kawase Y,
Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K,
Sato Y, Kuwahara K, Kimura T : Serum cholinesterase asa prognostic biomarker for acute heart failure. Eur Heart J
Acute Cardiovasc Care 10: 335-342, 2021.
20210170
Taki M, Miura T, Okina Y, Mochidome T,
Kobayashi T, Kasai T, Ikeda U, Ezawa N, Sekijima Y,
Kuwahara K : Searching for the Frequency of Cardiac
Transthyretin Amyloidosis among Elderly Heart Failure
Patients Noninvasively Using 99mTc-labeled Pyrophosphate
Scintigraphy. Shinshu Med J 69: 37-44, 2021.
20210171
Imanishi A, Ichise H, Fan C, Nakagawa
Y, Kuwahara K, Sumiyama K, Matsuda M, Terai K :Visualization of Spatially-Controlled Vasospasm by
Sympathetic Nerve-Mediated ROCK Activation. Am J

14

Pathol 191: 194-203, 2021.
20210172
Shiba M, Kato T, Morimoto T, Yaku H, Inuzuka
Y, Tamaki Y, Ozasa N, Seko Y, Yamamoto E, Yoshikawa
Y, Kitai T, Yamashita Y, Iguchi M, Nagao K, Kawase Y,
Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K,
Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators: Prognostic value of reduction in left atrial size during afollow-up of heart failure: an observational study. BMJ Open11: e044409, 2021.
20210173
Senda K, Miura T, Kato T, Kanzaki Y, Abe
N, Yokota D, Yanagisawa T, Okina Y, Wakabayashi T,
Oyama Y, Karube K, Itagaki T, Yoda H, Shoin K, Oguchi
Y, Aizawa K, Suzuki C, Kuwahara K; on behalf of the
I-PAD NAGANO registry investigators : Association of the
Prognosis of Ankle-brachial Index Improvement One Year
Following Endovascular Therapy in Patients with Peripheral
Artery Disease: Data from the I-PAD NAGANO Registry.
Intern Med 60: 1999-2006, 2021.
20210174
Wakabayashi S, Joshita S, Kimura K, Motoki
H, Kobayashi H, Yamashita Y, Sugiura A, Yamazaki
T, Kuwahara K, Umemura T : Protocol: Prospective
observational study investigating the prevalence and clinicaloutcome of portopulmonary hypertension in Japanesepatients with chronic liver disease. PLoS One 16: e0249435,
2021.
20210175
Itagaki T, Motoki H*, Otagiri K, Machida K,
Takeuchi T, Kanai M, Kimura K, Higuchi S, Minamisawa
M, Kitabayashi H, Kuwahara K : Inflammation-based
assessment for the risk stratification of mortality in patientswith heart failure. Sci Rep 11: 14989, 2021.
20210176
Seko Y, Kato T, Morimoto T, Yaku H, Inuzuka
Y, Tamaki Y, Ozasa N, Shiba M, Yamamoto E, Yoshikawa
Y, Kitai T, Yamashita Y, Iguchi M, Nagao K, Kawase Y,
Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K,
Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators: A decrease in tricuspid regurgitation pressure gradientassociates with favorable outcome in patients with heart
failure. ESC Heart Fail 8: 2826-2836, 2021.
20210177
Kawase Y, Kato T, Morimoto T, Hata R,
Murai R, Tada T, Katoh H, Kadota K, Yamamoto E, Yaku
H, Inuzuka Y, Tamaki Y, Ozasa N, Yoshikawa Y, Iguchi
M, Nagao K, Sato Y, Kuwahara K, Kimura T : Admission
systolic blood pressure as a prognostic predictor of acutedecompensated heart failure: A report from the KCHF
registry. PLoS One 16: e0253999, 2201.
20210178

Tamaki Y, Yaku H, Morimoto T, Inuzuka Y,

Ozasa N, Yamamoto E, Yoshikawa Y, Miyake M, Kondo
H, Tamura T, Kitai T, Iguchi M, Nagao K, Nishikawa R,
Kawase Y, Morinaga T, Kawato M, Toyofuku M, Sato
Y, Kuwahara K, Nakagawa Y, Kato T, Kimura T; KCHF
Study Investigators : Lower In-Hospital Mortality With
Beta-Blocker Use at Admission in Patients With Acute
Decompensated Heart Failure. J Am Heart Assoc 10:
e020012, 2021.
20210179
Okina Y, Miura T, Senda K, Taki M, Kobayashi
M, Kanai M, Okuma Y, Yanagisawa T, Hashizume N, Otagiri
K, Shoin K, Watanabe N, Ebisawa S, Karube K, Nakajima
H, Saigusa T, Miyashita Y, Kashiwagi D, Machida K, Abe N,
Tachibana T, Kanzaki Y, Maruyama T, Nomi H, Sakai T, Yui
H, Mochidome T, Kobayashi T, Kasai T, Ikeda U, Kuwahara
K : Prognostic ability of mid-term worsening renal function
after percutaneous coronary intervention: findings from the
SHINANO registry. Heart Vessels 36: 1496-1505, 2021.
20210180
Kobayashi H, Okada A*, Tabata H, Shoin W,
Okano T, Yoshie K, Oguchi Y, Kato K, Motoki H, Shoda
M, Kuwahara K : Association between Inter-atrial Septum
motion and Persistent Atrial Fibrillation Recurrence after
Catheter Ablation. Shinshu Med J 69: 189-201, 2021.
20210181
Kato T, Nagae A, Sakai T, Saigusa T, Ebisawa
S, Kuwahara K : Successful bailout of stent graft stuck instent occlusion lesion. Cardiovasc Interv Ther 36: 535-536,
2021.
20210182
Miura T, Ueki Y, Senda K, Otagiri K, Tachibana
T, Saigusa T, Ebisawa S, Motoki H, Ikeda U, Kuwahara K :Early vascular response of ultra‑thin bioresorbable polymer
sirolimus‑eluting stents assessed by optical frequency
domain imaging: the EVALUATION study. Cardiovasc
Interv Ther 36: 281-288, 2021.
20210183
Fujimori K, Okada A, Tabata H, Shoda M,
Kuwahara K : Percutaneous removal of a displaced inferior
vena cava filter using a loop-wire technique and leadextraction sheaths. Circ J 85: 1403, 2021.
20210184
Minamisawa M, Inciardi RM, Claggett B,
Cuddy SAM, Quarta CC, Shah AM, Dorbala S, Falk RH,
Matsushita K, Kitzman DW, Chen LY, Solomon SD : Leftatrial structure and function of the amyloidogenic V122I
transthyretin variant in elderly African Americans. Eur J
Heart Fail 23: 1290-1295, 2021.
20210185
Sunohara D, Miura T, Komatsu T, Hashizume
N, Momose T, Kono T, Motoki H, Mochidome T, Kasai
T, Kuwahara K, Ikeda U : Relationship between the flood
disaster caused by the Reiwa first year east Japan typhoon

15

and cardiovascular and cerebrovascular events in Nagano
City: The SAVE trial. J Cardiol 78: 447-455, 2021.
20210186
Yoshie K, Yamasaki M, Yokoyama M, Ueki Y,
Tachibana E, Yonemoto N, Nagao K : Prognostic beneitsof prior amiodarone or β-blocker use before the onset ofventricular arrhythmia with hemodynamic collapse. Heart
Vessels 36: 1430-1437, 2021.
20210187
Yanagisawa S, Takahashi Y, Sasaki J, Takasone
K, Yoshie K, Koyama J, Katoh N, Yazaki M, Kuwahara
K, Fujinaga Y, Sekijima Y : Absolute quantitative analysis
of cardiac amyloidosis using SPECT/CT with (99m)
Tc-pyrophosphate. Amyloid 28: 213-214, 2021.
20210188
Itagaki T, Ebisawa S*, Otagiri K, Kato T, Miura
T, Kanzaki Y, Abe N, Yokota D, Yanagisawa T, Senda K,
Okina Y, Wakabayashi T, Oyama Y, Karube K, Machida K,
Takeuchi T, Saigusa T, Motoki H, Kitabayashi H, Kuwahara
K : Body composition and mortality in patients undergoingendovascular treatment for peripheral artery disease. Heart
Vessels 36: 1830-1840, 2021.
20210189
Minamisawa M, Claggett B, Suzuki K, Hegde
SM, Shah AM, Desai AS, Lewis EF, Shah SJ, Sweitzer NK,
Fang JC, Anand IS, O'Meara E, Rouleau JL, Pitt B, Pfeffer
MA, Solomon SD, Vardeny O : Association of HyperPolypharmacy With Clinical Outcomes in Heart Failure With
Preserved Ejection Fraction. Circ Heart Fail 14: e008293,
2021.
20210190
Iguchi M, Kato T, Yaku H, Morimoto T, Inuzuka
Y, Tamaki Y, Ozasa N, Yamamoto E, Yoshikawa Y, Kitai T,
Hamatani Y, Yamashita Y, Masunaga N, Ogawa H, Ishii M,
An Y, Taniguchi R, Kato M, Takahashi M, Jinnai T, Ikeda
T, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y,
Morinaga T, Kawato M, Seko Y, Toyofuku M, Furukawa Y,
Ando K, Kadota K, Abe M, Akao M, Sato Y, Kuwahara K,
Kimura T : Ischemic Stroke in Acute Decompensated Heart
Failure: From the KCHF Registry. J Am Heart Assoc 10:
e022525, 2021.
20210191
Seko Y, Kato T, Morimoto T, Yaku H, Inuzuka
Y, Tamaki Y, Ozasa N, Shiba M, Yamamoto E, Yoshikawa
Y, Yamashita Y, Kitai T, Taniguchi R, Iguchi M, Nagao K,
Jinnai T, Komasa A, Nishikawa R, Kawase Y, Morinaga
T, Toyofuku M, Furukawa Y, Ando K, Kadota K, Sato Y,
Kuwahara K, Kimura T; KCHF Study Investigators : Newly
Diagnosed Infection After Admission for Acute Heart
Failure: From the KCHF Registry. J Am Heart Assoc 10:
e023256, 2021.
20210192

Seko Y, Kato T, Morimoto T, Yaku H, Inuzuka

Y, Tamaki Y, Ozasa N, Shiba M, Yamamoto E, Yoshikawa
Y, Kitai T, Yamashita Y, Iguchi M, Nagao K, Kawase Y,
Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K,
Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators: Improved and new-onset anemia during followup in patients with acute decompensated heart failure:
Characteristics and outcomes. Medicine (Baltimore) 100:e26892, 2021.
20210193
Washida K, Kato T, Ozasa N, Morimoto T, Yaku
H, Inuzuka Y, Tamaki Y, Seko Y, Yamamoto E, Yoshikawa
Y, Kitai T, Yamashita Y, Iguchi M, Nagao K, Kawase Y,
Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K,
Sato Y, Kuwahara K, Kimura T : Risk Factors and Clinical
Outcomes of Nonhome Discharge in Patients With Acute
Decompensated Heart Failure: An Observational Study. J
Am Heart Assoc 10: e020292, 2021.
20210194
Suzuki K, Claggett B, Minamisawa M,
Nochioka K, Mitchell GF, Anand IS, Zannad F, Shah SJ,
Lefkowitz M, Shi V, Pfeffer MA, McMurray JJV, Solomon
SD : Pulse Pressure, Prognosis, and Influence of Sacubitril/
Valsartan in Heart Failure With Preserved Ejection Fraction.
Hypertension 77: 546-556, 2021.
20210195
Biering-Sørensen T, Minamisawa M, Liu J,
Claggett B, Papolos AI, Felker GM, McMurray JJV, Legg
JC, Malik FI, Honarpour N, Kurtz CE, Teerlink JR, Solomon
SD : The effect of the cardiac myosin activator, omecamtiv
mecarbil, on right ventricular structure and function inchronic systolic heart failure (COSMIC-HF). Eur J Heart
Fail 23: 1052-1056, 2021.

Pediatrics
20210196
Hasegawa A, Saito S*, Narimatsu S, Nakano S,
Nagai M, Ohnota H, Inada Y, Morokawa H, Nakashima I,
Morita D, Ide Y, Matsuda K, Tashiro H, Yagyu S, Tanaka M
and Nakazawa Y* : Mutated GM-CSF-based CAR-T cells
targeting CD116/CD131 complexes exhibit enhanced antitumor effects against acute myeloid leukaemia. Clin Transl
Immunology 10: e1282, 2021.
20210197
Hirabayashi K, Du H, Xu Y, Shou P, Zhou X,
Fuca G, Landoni E, Sun C, Chen Y, Savoldo B and Dotti G: Dual Targeting CAR-T Cells with Optimal Costimulationand Metabolic Fitness enhance Antitumor Activity andPrevent Escape in Solid Tumors. Nat Cancer 2: 904-918,
2021.
20210198
Matsuoka D, Hirabayashi K*, Murase T, Saito S
and Nakazawa Y : Impact of acute kidney injury on overall
survival in children and young adults undergoing allogeneic

16

hematopoietic stem cell transplantation. Pediatr Blood
Cancer 68: e29167, 2021.
20210199
Motoki N, Motoki H, Utsumi M, Yamazaki
S, Obinata H, Takei K and Yasukochi S : Identificationof metabolomic profile related to adult Fontan
pathophysiology. Int J Cardiol Heart Vasc 37: 100921, 2021.
20210200
Nakamura C, Miyosawa Y*, Motoki N,
Yanagisawa T, Hirabayashi K, Ishida T, Nakazawa Y andNakamura T : Relationship between placental weight andlate-onset circulatory collapse. Pediatr Int 63: 1205-1211,
2021.
20210201
Nakamura K, Yagyu S, Hirota S, Tomida
A, Kondo M, Shigeura T, Hasegawa A, Tanaka M and
Nakazawa Y : Autologous antigen-presenting cells
efficiently expand piggyBac transposon CAR-T cells withpredominant memory phenotype. Mol Ther Methods Clin
Dev 21: 315-324, 2021.
20210202
Ogawa A, Watanabe T, Natsume T, Okura E,
Saito S, Kato S, Nakayama Y, Furukawa S, Yamaguchi T,
Kosho T, Uehara T, Kobayashi N, Agematsu K, Nakazawa
Y and Shigemura T* : Early-Onset Inflammatory Bowel
Disease Caused by Mutations in the X-Linked Gene IL2RG.
J Investig Allergol Clin Immunol 31: 69-71, 2021.
20210203
Shibazaki T, Motoki N, Misawa Y, Ohira S,
Inaba Y, Kanai M, Kurita H, Nakazawa Y, Tsukahara T,
Nomiyama T, Japan E and Children's Study G : Association
between pesticide usage during pregnancy and neonatal
hyperbilirubinemia requiring treatment: the Japan
Environment and Children's Study. Pediatr Res 89: 15651570, 2021.
20210204
Shigemura T*, Maruyama Y, Shigeto S,
Nakazawa Y and Kanno H : Orbital Epstein-Barr virusrelated post-transplant lymphoproliferative disorder in a
13-year-old girl with cord blood transplantation. Transpl
Infect Dis 23: e13536, 2021.
20210205
Tsukahara T, Matsuoka D*, Shimada S,
Hachiya A and Motoki N : Myocardial ischemia during
methylprednisolone pulse therapy with dipyridamole. Pediatr
Int 63: 722-723, 2021.
20210206
Yagyu S, Mochizuki H, Yamashima K, Kubo H,
Saito S, Tanaka M, Sakamoto K, Shimoi A and Nakazawa
Y* : A lymphodepleted non-human primate model forthe assessment of acute on-target and off-tumor toxicity
of human chimeric antigen receptor-T cells. Clin Transl
Immunology 10: e1291, 2021.

20210207
Yamazaki S, Akazawa Y*, Obinata H, Motoki
N, Takei K, Yasukochi S and Takigiku K : Ventricularmyocardial response to exercise in patients with Fontan
circulation. J Echocardiogr 19: 212-221, 2021.

Dermatology
20210208
Nakamura K*, Kosano M, Sakai Y, Saito N,
Takazawa Y, Omodaka T, Kiniwa Y, Okuyama R : Case ofbullous pemphigoid following coronavirus disease 2019vaccination. J Dermatol 48(12): e606-e607, 2021.
20210209
Midorikawa H, Kiniwa Y*, Minagawa A,
Osawa K, Shirai T, Sano T, Nakamura K, Ashida A,
Ueno KI, Takeichi T, Akiyama M, Okuyama R : Case ofannular pustular psoriasis/circinate erythematous psoriasis
induced by hydroxychloroquine in a patient with systemic
lupus erythematosus: Possible association with CARD-14
mutation. J Dermatol 48(9): e440-e442, 2021.
20210210M e l i n g M T, K i n i w a Y, O g a w a E , S a t o
Y, Okuyama R* : Increased expression of secreted
protein acidic and rich in cysteine and tissue inhibitor of
metalloproteinase-3 in epidermotropic melanoma metastasis.
J Dermatol 48(11): 1772-1779, 2021.
20210211
Sano K, Asahina M, Uehara T, Araki N,
Yamanaka Y, Matsumoto K, Okuyama R : Clear cell injury
associated with reduced expression of carbonic anhydrase
II in eccrine glands consistently occurs in patients withacquired idiopathic generalized anhidrosis. J Dermatol
48(4): 439-446, 2021.
20210212
Minagawa A, Koga H, Sano T, Matsunaga
K, Teshima Y, Hamada A, Houjou Y, Okuyama R*: Dermoscopic diagnostic performance of Japanesedermatologists for skin tumors differs by patient origin: A
deep learning convolutional neural network closes the gap. J
Dermatol 48(2): 232-236, 2021.
20210213
Kawashima S, Inozume T, Kawazu M, Ueno T,
Nagasaki J, Tanji E, Honobe A, Ohnuma T, Kawamura T,
Umeda Y, Nakamura Y, Kawasaki T, Kiniwa Y, YamasakiO, Fukushima S, Ikehara Y, Mano H, Suzuki Y, Nishikawa
H, Matsue H, Togashi Y : TIGIT/CD155 axis mediates
resistance to immunotherapy in patients with melanoma with
the inflamed tumor microenvironment. J Immunother Cancer
9(11): e003134, 2021.
20210214
Umeda Y, Yoshikawa S, Kiniwa Y, Maekawa
T, Yamasaki O, Isei T, Matsushita S, Nomura M, Nakai
Y, Fukushima S, Saito S, Takenouchi T, Tanaka R, Kato
H, Otsuka A, Matsuya T, Baba N, Nagase K, Inozume T,

17Onuma T, Kuwatsuka Y, Fujimoto N, Kaneko T, Onishi
M, Namikawa K, Yamazaki N, Nakamura Y : Real-world
efficacy of anti-PD-1 antibody or combined anti-PD-1 plus
anti-CTLA-4 antibodies, with or without radiotherapy, inadvanced mucosal melanoma patients: A retrospective,
multicenter study. Eur J Cancer 157: 361-372, 2021.
20210215
Kiniwa Y, Okuyama R* : Recent advances inmolecular targeted therapy for unresectable and metastatic
BRAF-mutated melanoma. Jpn J Clin Oncol 51(3): 315-320,
2021.
20210216
Sano T, Minagawa A*, Suzuki R, Koga H,
Okuyama R : Dermoscopy with near-ultraviolet lighthighlights the demarcation of melanin distribution in
cutaneous melanoma. J Am Acad Dermatol 84(1): e23-e24,
2021.
20210217
Makino T, Ihn H, Nakagawa M, Urano M,
Okuyama R, Katoh N, Tateishi C, Masuda K, Ogawa E,
Nishida E, Nishimoto S, Muramoto K, Tsuruta D, Morita A: Effect of adalimumab on axial manifestations in Japanesepatients with psoriatic arthritis: a 24 week prospective,
observational study. Rheumatology 60(8): 3669-3678, 2021.
20210218
Miyake T, Minagawa A*, Ito S, Yokokawa Y,
Wakamatsu K, Okuyama R : Utility of Melanin Degradation
Products in the Nail for Diagnosing Nail Apparatus
Melanoma. Acta Derm Venereol 101(2): adv00387, 2021.
20210219
Umaru BA, Kagawa Y, Shil SK, Arakawa N,
Pan Y, Miyazaki H, Kobayashi S, Yang S, Cheng A, Wang Y,
Shinoda Y, Kiniwa Y, Okuyama R, Fukunaga K, Owada Y :Ligand bound Fatty acid binding protein 7 (FABP7) drives
melanoma cell proliferation via modulation of Wnt/β-cateninsignaling. Pharm Res 38(3): 479-490, 2021.
20210220
Omodaka T, Minagawa A*, Okuyama R :Ultraviolet-related skin cancers distribute differently on theface surface. Br J Dermatol 185(1): 205-207, 2021.
20210221
Kiniwa Y, Nakamura K, Mikoshiba A, Ashida
A, Akiyama Y, Morimoto A, Okuyama R* : Usefulnessof monitoring circulating tumor cells as a therapeutic
biomarker in melanoma with BRAF mutation. BMC Cancer
21(1): 287, 2021.
20210222
Nakamura K*, Kiniwa Y, Okuyama R : CCL5
production by fibroblasts through a local renin-angiotensin
system in malignant melanoma affects tumor immune
responses. J Cancer Res Clin Oncol 147(7): 1993-2001,
2021.

20210223
Meling MT, Minagawa A*, Miyake T, Ashida
A, Okuyama R : Certolizumab pegol treatment for leg ulcers
due to rheumatoid vasculitis. JAAD Case Rep 18: 12-14,2021.
20210224
Nakamura Y, Namikawa K, Yoshikawa S,
Kiniwa Y, Maekawa T, Yamasaki O, Isei T, Matsushita S,
Nomura M, Nakai Y, Fukushima S, Saito S, Takenouchi T,
Tanaka R, Kato H, Otsuka A, Matsuya T, Baba N, Nagase
K, Inozume T, Fujimoto N, Kuwatsuka Y, Onishi M, Kaneko
T, Onuma T, Umeda Y, Ogata D, Takahashi A, Otsuka M,
Teramoto Y, Yamazaki N : Anti-PD-1 antibody monotherapy
versus anti-PD-1 plus anti-CTLA-4 combination therapy
as first-line immunotherapy in unresectable or metastatic
mucosal melanoma: a retrospective, multicenter study of 329
Japanese cases (JMAC study). ESMO Open 6(6): 100325,
2021.
20210225
Ansai SI, Umebayashi Y, Katsumata N, Kato
H, Kadono T, Takai T, Namiki T, Nakagawa M, Soejima T,
Koga H, Sugaya M : Japanese Dermatological Association
Guidelines: Outlines of Guidelines for Cutaneous Squamous
Cell Carcinoma 2020. J Dermatol 48(7): e288-e311, 2021.
20210226
Ohtsuka M, Hamada T, Miyagaki T, Shimauchi
T, Yonekura K, Kiyohara E, Fujita H, Izutsu K, Okuma K,
Kawai K, Koga H, Sugaya M : Outlines of the Japaneseguidelines for the management of primary cutaneous
lymphomas 2020. J Dermatol 48(2): e49-e71, 2021.

Radiology
20210227
Ohya A*, Ichinohe F, Matoba H, Kobara H,
Fujinaga Y : Useful preoperative examination findings
to classify the grade of ovarian primary mucinous tumor.
Abdominal Radiology 46: 2393-2402, 2021.
20210228
Ohya A*, Kobara H, Miyamoto T, Komatsu M,
Shiozawa T, Fujinaga Y : Usefulness of the 'cosmos pattern'for defferentiating between cervical gastaric-type mucinpositive lesions and other benign cervical cystic lesions inmagnetic resonance images. J Obstet Gynaecol Res 47: 745756, 2021.
20210229
Tsukahara Y, Okajima Y, Yamada A, Momose
M, Uehara T, Shimizu A, Soejima Y, Fujinaga Y : The
peritumoral hypointense rim around hepatocellular
carcinoma on T2*-weighted magnetic resonance imaging:radiologic-pathologic correlation. World J Surg Oncol 19:41, 2021.
20210230
Suzuki T, Aonuma T, Oyama K, Yamada
A , K i t o h Y, A d a c h i Y, H a y a s h i h a r a H , M a r c e l D

18

Nickel, Maruyama K, Fujinaga Y : High-resolution
three-demensional T1-weighted hepatobiliary MR
cholangiography using Gd-EOB-DTPA for assessment ofbiliary tree anatomy:Parallel imaging versus compressedsensing. World J Surg Oncol 136: 109515, 2021.
20210231
Notake T, Shimizu A, Kubota K, Ikehara T,
Hayashi H, Yasukawa K, Kobayashi A, Yamada A, Fujinaga
Y, Soejima Y : Hepatocellular uptake index obtained withgadoxetate disodium-enhanced magnetic resonance imaging
in the assessment future liver remnant function after major
hepatectomy for biliary malignancy. BJS Open 48: 1-8,
2021.

20210239
Yamada A*, Yoshizawa E* : Quantitative
assessment of liver steatosis using ultrasound:dual-energy
CT. J Med Ultrason 48: 507-514, 2021.
20210240
Minagawa T, Oguchi T, Saitou T, Fukazawa A,
Hashida I, Koiwai K, Iijima K, Kato H, Ogawa T, Ishizuka
O : Impact of low-dose tadalafil on adverse events after lowdose-rate brachytherapy for prostate cancer: A bi-center
randomized open-label trial. Int J Urol 28: 432-438, 2021.

Division of Gastroenterological, HepatoBiliary-Pancreatic, Transplantation andPediatric Surgery

20210232
Yanagisawa S, Takahashi Y, Sasaki J, Takasone
K, Yoshie K, Koyama J, Katoh N, Yazaki M, Kuwahara K,
Fujinaga Y*, Sekijima Y : Absolute quantitative analysis
of cardiac amyloidosis using SPECT/CT with 99mTcpyrophosphate. Amyloid 28: 213-214, 2021.

20210241
Hondo N, Miyagawa Y*, Kitazawa M,
Muranaka F, Tokumaru S, Koyama M, Takahata S, Soejima
Y : Laparoscopic abdominosacral resection for rectal andanal canal carcinoma with pagetoid spread. Asian J Endosc
Surg 14: 624-627, 2021.

20210233
Ohya A*, Matoba H, Fujinaga Y, Nakayama
J : Decreased Gastric Gland Mucin-specific 0-glycans Are
Involved in the Progression of Ovarian Primary Mucinous
Tumours. Acta Histochem Cytochem 54: 115-122, 2021.

20210242
Yamamoto Y*, Miyagawa Y, Kitazawa M,
Tanaka H, Kuroiwa M, Hondo N, Koyama M, Nakamura S,
Tokumaru S, Muranaka F, Soejima Y : Association of feces
sign with prognosis of non-emergency adhesive small bowel
obstruction. World J Surg 44: 292-297, 2021.

20210234
I w a k a w a H , U c h i y a m a S , F u j i n a g a Y,
Hayashi M, Komatsu M, Kato H, Takahashi J : Magnetic
resonance imaging of diffusion characteristics followingc ol l a g enas e cl os t ri di um hi s t ol yt i c u m in je c tio n in
Dupuytren's contracture. J Orthop Surg (Hong Kong) 29:
23094990211047200, 2021.
20210235
Fukamatsu F, Yamada A*, Hayashihara H,
Kitou Y, Fujinaga Y : Optimization of scan protocol for hightemporal resolution magnetic resonance imaging of the liver
under single breath-holding using compressed sensing andparallel imaging techniquies in a 1.5-T magnetic resonancesystem. BJS Open 3: 1-11, 2021.
20210236
Minatogawa M, Tsukahara Y, Yuzuriha S,
Kosho T : Detailed clinical and radiological features of thefirst patient with Elsahy-Waters syndrome in East Asia. Am J
Med Genet A 185: 3909-3915, 2021.
20210237
M a t s u s h i t a H , O z a w a T, S e k i g u c h i N ,Fukushima T, Kobayashi T, Kanda S, Koizumi T : A Caseof Sinonasal Undifferentiated Carcinoma Sucessfully
Responding to Chemoradiotherapy. Shinshu Medical Journal
69: 121-126, 2021.
20210238
Yoshizawa E*, Yamada A* : MRI-derived
proton density fat fraction. J Med Ultrason 48: 497-506,
2021.

20210243
Yasukawa K*, Shimizu A, Motoyama H,
Kubota K, Notake T, Fukushima K, Ikehara T, Hayashi H,
Kobayashi A, Soejima Y : Impact of Remnant Carcinoma
in Situ at the Ductal Stump on Long-Term Outcomes inPatients with Distal Cholangiocarcinoma. World J Surg 45:
291-301, 2021.
20210244
Shimizu A*, Motoyama H, Kubota K, Notake
T, Fukushima K, Ikehara T, Hayashi H, Yasukawa K,
Kobayashi A, Soejima Y : Safety and Oncological Benefit of
Hepatopancreatoduodenectomy for Advanced Extrahepatic
Cholangiocarcinoma with Horizontal Tumor Spread:
Shinshu University Experience. Ann Surg Oncol 28: 20122025, 2021.
20210245
Yasukawa K*, Shimizu A, Kubota K, Notake T,
Sugenoya S, Hosoda K, Hayashi H, Kobayashi R, Soejima
Y : Clinical characteristics and management of acutecholecystitis after cardiovascular surgery. J Hepatobiliary
Pancreat Sci 28: 211-220, 2021.
20210246
Yamamoto Y*, Miyagawa Y, Kitazawa M,
Tokumaru S, Muranaka F, Soejima Y : A perpendicularapproach to mesorectal excision using an articulating tissue
sealer in laparoscopic sigmoidectomy - a video vignette.
Colorectal Dis 23: 1008, 2021.

1920210247
Hosoda K*, Shimizu A, Kubota K, Notake T,
Sugenoya S, Yasukawa K, Hayashi H, Kobayashi R, Soejima
Y : A focal extramedullary hematopoiesis of the spleen ina patient with essential thrombocythemia presenting with acomplicated postoperative course: a case report. Surg Case
Rep 7: 33, 2021.
20210248
Yasukawa K*, Shimizu A, Motoyama H,
Kubota K, Notake T, Sugenoya S, Hosoda K, Hayashi H,
Kobayashi R, Soejima Y : Applicability of sentinel lymph
node oriented treatment strategy for gallbladder cancer.
PLoS One 16: e0247079, 2021.
20210249
Yasukawa K*, Shimizu A, Kubota K, Notake
T, Sugenoya S, Hosoda K, Ikehara T, Hayashi H, Kobayashi
R, Soejima Y : The survival benefit of surgery for perihilar
cholangiocarcinoma in octogenarians. J Surg Oncol 124:
67-78, 2021.
20210250
Iguchi T, Shimizu A*, Kubota K, Notake T,
Sugenoya S, Hosoda K, Yasukawa K, Hayashi H, Kobayashi
R, Soejima Y : Lymphoepithelial cyst mimicking pancreaticcancer: a case report and literature review. Surg Case Rep 7:108, 2021.
20210251
Hayashi H*, Shimizu A, Motoyama H,
Kubota K, Notake T, Sugenoya S, Hosoda K, Yasukawa
K, Kobayashi R, Soejima Y : Usefulness and limitation of
indocyanine green fluorescence for detection of peritoneal
recurrence after hepatectomy for hepatocellular carcinoma: acase report. BMC Surgery 21: 107, 2021.
20210252
Ehara T, Uehara T, Nakajima T, Kinugawa
Y, Kobayashi S, Iwaya M, Ota H, Soejima Y : LGR5
expression is associated with prognosis in poorly
differentiated gastric adenocarcinoma. BMC Cancer 21: 228,
2021.
20210253
Kitazawa M*, Miyagawa Y, Koyama M,
Nakamura S, Hondo N, Miyazaki S, Muranaka F, Tokumaru
S, Yamamoto Y, Ehara T, Kuroiwa M, Tanaka H, Komatsu
D, Takeoka M, Soejima Y : Drug sensitivity profile ofminor KRAS mutations in colorectal cancer using mix
culture assay: The effect of AMG‑510, a novel KRAS
G12C selective inhibitor, on colon cancer cells is markedly
enhanced by the combined inhibition of MEK and BCL‑XL.
Mol Clin Oncol 15: 148, 2021.
20210254
Yamazaki S*, Shimodaira Y, Kobayashi A,
Takata M, Hayashibara K, Sakon M, Sekino Y, Okada M,
Takahashi Y, Shimura M, Seki H, Soejima Y : Predictive
factors of perforated appendicitis: Impact of the C-reactive
protein level. Surg Open Sci 6: 1-4, 2021.

20210255
Notake T, Shimizu A*, Kubota K, Ikehara T,
Hayashi H, Yasukawa K, Kobayashi A, Yamada A, Fujinaga
Y, Soejima Y : Hepatocellular uptake index obtained withgadoxetate disodium-enhanced magnetic resonance imaging
in the assessment future liver remnant function after major
hepatectomy for biliary malignancy. BJS Open 5: zraa048,
2021.
20210256
Tokumaru S*, Koizumi T, Sekino Y, Takeuchi
N, Nakata S, Miyagawa Y, Kitazawa M, Muranaka F,
Nakamura S, Koyama M, Yamamoto Y, Ehara T, Hondo N,
Soejima Y : Lymphocyte-to-Monocyte Ratio Is a Predictive
Biomarker of Response to Treatment with Nivolumab for
Gastric Cancer. Oncology 99: 632-640, 2021.
20210257
Yamamoto Y*, Miyagawa Y, Kitazawa M,
Koyama M, Nakamura S, Tokumaru S, Muranaka F, Soejima
Y : Sex differences in non-strangulated postoperativeadhesive small bowel obstruction: A retrospective cohort
study. ANZ J Surg 91: 2074-2080, 2021.
20210258
Takagi Y, Koyama M*, Miyagawa Y, Kitazawa
M, Kimura K, Soejima Y : A case of sigmoidectomy forsigmoid colon cancer with severe pulmonary arterial
hypertension associated with mixed tissue connecteddisease: A case report. Int J Surg Case Rep 83: 105906,
2021.
20210259
Kobayashi R*, Shimizu A, Kubota K, Notake
T, Sugenoya S, Hosoda K, Hayashi H, Yasukawa K, SatohY, Iwaya M, Sano K, Soejima Y : Maffucci Syndrome with
Intrahepatic Cholangiocarcinoma: A Case Report. Case Rep
Oncol 14: 1347-1352, 2021.
20210260
Hosoda K*, Fukushima K, Shimizu A,
Motoyama H, Kubota K, Notake T, Sugenoya S, Hayashi H,
Yasukawa K, Kobayashi R, Soejima Y : Survival Outcomesof Gemcitabine Plus S-1 Adjuvant Chemotherapy after
Surgical Resection for Advanced Biliary Tract Cancer.
Oncology 99: 703-712, 2021.
20210261
Shimizu T, Hondo N, Miyagawa Y, Kitazawa
M*, Muranaka F, Tokumaru S, Nakamura S, Koyama M,
Yamamoto Y, Ehara T, Miyazaki S, Iijima Y, Iwaya M,
Soejima Y : A case of appendiceal ganglioneuroma inneurofibromatosis type 1. Surg Case Rep 7: 218, 2021.
20210262
Tomida H*, Nakagawa K, Matsumura H,
Imai S, Matsushita A, Koike S : Perforated Duodenal
Diverticulum With Postoperative Diverticulum Bleeding
Successfully Treated Using Transcatheter Arterial
Embolization. Cureus 13: e18219, 2021.

20

20210263
Kuroiwa M, Kitazawa M*, Miyagawa Y,
Muranaka F, Tokumaru S, Nakamura S, Koyama M,
Yamamoto Y, Hondo N, Ehara T, Miyazaki S, Tanaka H,
Soejima Y : Mesh Migration into the Neobladder and Ileumwith Complicated Fistula Formation following Incisional
Hernia Repair. Case Rep Surg 2021: 5683621, 2021.
20210264
Soejima Y*, Taguchi T, Matsuura T, Hayashida
M, Ikegami T, Yoshizumi T, Maehara Y : Rex Shunt for
Portal Vein Thrombosis After Pediatric Living Donor Liver
Transplantation. Ann Transplant 26: e909493, 2021.
20210265
Shimizu A*, Soejima Y : ASO Author
Reflections: Is Major Hepatopancreatoduodenectomy
Beneficial for Patients with Advanced and Widespread
Extrahepatic Cholangiocarcinoma?. Ann Surg Oncol 28:
2026-2027, 2021.
20210266
Yamazaki S*, Shimodaira Y, Kobayashi A,
Takata M, Hayashibara K, Sakon M, Sekino Y, Okada M,
Takahashi Y, Seki H, Soejima Y : Successful Treatmentof Protein-Losing Enteropathy After Superior Mesenteric
Artery Occlusion without Surgery. Am J Case Rep 22:
e931114, 2021.

Division of Cardiovascular Surgery
20210267
G o m i b u c h i T, S e t o T, N a i t o K , C h i n o
S, Mikoshiba T, Komatsu M, Tanaka H, Ichimura H,
Yamamoto T, Nakahara K, Ohashi N, Fuke M, Wada Y,
Okada K : Strategies to improve outcomes for acute type
A aortic dissection with cerebral malperfusion. Eur J
Cardiothorac Surg 59(3): 666-673, 2021.

Division of General Thoracic Surgery
20210268
Nakamura D, Kobayashi N, Miyazawa M,
Miura K, Satomi H : Pulmonary metastasis with coexisting
pulmonary mucosa-associated lymphoid tissue (MALT)
lymphoma 20 years after endometrioid adenocarcinoma
surgery: A case report . Thorac Cancer 12: 402-406, 2021.
20210269
Matsuoka S, Eguchi T, Takeda T, Miura K,
Hamanaka K, Shimizu K* : Three‑dimensional computed
tomography and indocyanine green‑guided technique forpulmonary sequestration surgery. Gen Thorac Cadiovasc
Surg 69: 621-624, 2021.
20210270
Ohtaki Y, Shimizu K*, Suzuki H, Suzuki K,
Tsuboi M, Mitsudomi T, Takao M, Murakawa T, Ito H,
Yoshimura K, Okada M, Chida M; Japanese Association
for Chest Surgery : Salvage surgery for non-small cell lungcancer after tyrosine kinase inhibitor treatment. Lung Cancer

153: 108-116, 2021.
20210271
Kimura Kuroiwa K, Shiko Y, Kawasaki Y, Aoki
Y, Nishizawa M, Ide S, Miura K, Kobayashi N, Sehmbi H :Phrenic Nerve Block at the Azygos Vein Level Versus Sham
Block for Ipsilateral Shoulder Pain After Video-Assisted
Thoracoscopic Surgery: A Randomized Controlled Trial .
Anesth Analg 132: 1594-1602, 2021.
20210272
Eguchi T*, Hamanaka K, Shimizu K : Thymic
malignancy still needs aggressive surgery: safety andoncologic feasibility of superior vena cava resection. Ann
Thorac Surg 112: 277-278, 2021.
20210273
Nakazawa S, Hanawa R, Nagashima T, Shimizu
K, Yajima T, Shirabe K : Segmentectomy Guided by
3-Dimensional Images Reconstructed from Nonenhanced
Computed Tomographic Data. Ann Thorac Surg 111:
e301-e304, 2021.
20210274
Koyama T, Shimizu K*, Uehara T, Matsuoka
S, Takeda T, Yamada K, Eguchi T, Hamanaka K, Sano K :Synchronous triple primary lung cancer with three different
histological subtypes in the same lobe: A case report. Thorac
Cancer 12: 711-714, 2021.
20210275
Mishima S, Mishima O, Azuhata K, Shimojo
H, Ito N, Misawa K, Shimizu K : Angiomatoid fibrosis
histiocytoma in the pulmonary artery: A case report . Thorac
Cancer 12: 1453-1456, 2021.
20210276
Miura K, Shimizu K*, Eguchi T, Koike S,
Matsuoka S, Takeda T, Hamanaka K, Uehara T : Usefulness
of SS18-SSX antibody as a diagnostic marker for pulmonary
metastatic synovial sarcoma. Diagn Pathol 16: 54, 2021.
20210277
Eguchi T, Sato T, Shimizu K* : Technical
Advances in Segmentectomy for Lung Cancer: A Minimally
Invasive Strategy for Deep, Small,and Impalpable Tumors.
Cancers 13: 3137, 2021.
20210278
Shimizu K*, Ohtaki Y, Suzuki K, Date H,
Yamashita M, Iizasa T, Ito H, Yoshimura K, Okada M,
Chida M; Japanese Association for Chest Surgery : Salvage
Surgery for Non-Small Cell Lung Cancer After Definitive
Radiotherapy . Ann Thorac Surg 112: 862-873, 2021.
20210279
M a t s u o k a S , E g u c h i T, K o y a m a T,
Takeda T, Miura K, Hamanaka K, Shimizu K : Threedimensional computed tomography-guided excision of an
intrathoracic giant thymoma with elongated thymic vessels.
Multimed Man Cardiothorac Surg 2021: doi: 10.1510/
mmcts.2021.039, 2021.

21

20210280
Miura K, Shimizu K*, Ide S, Mishima S,
Matsuoka S, Takeda T, Eguchi T, Hamanaka K, Uehara T : A
Novel Strategy for the Diagnosis of Pulmonary High-Grade
Neuroendocrine Tumor . Diagnostics 11: 1945, 2021.

Division of Breast and Endocrine Surgery
20210281
Watanabe T, Oba T, Tanimoto K, Shibata T,
Kamijo S, Ito K* : Tamoxifen resistance alters sensitivity to
5-fluorouracil in a subset of estrogen receptor-positive breast
cancer. Plos One 16: e0252822, 2021.
20210282
Ono M, Oba T, Shibata T, Ito K* : The
mechanisms involved in the resistance of estrogen receptorpositive breast cancer cells to palbociclib are multiple andchange over time. J Cancer Res Clin Oncol 147: 3211-3224,
2021.
20210283
Nakajima H, Maeno K, Ito T, Kanai T, Oba T,
Ono M, Takayama F, Uehara T, Ito K* : Concomitant useof 18F-FDG PET-CT SUVmax is useful in the assessmentof Ki67 labeling index in core-needle biopsy specimens ofbreast cancer. Gland Surg 10: 1-9, 2021.
20210284
Oba T, Ono M, Matoba H, Uehara T, Hasegawa
Y, Ito K* : HDAC6 inhibition enhances the anti-tumor effectof eribulin through tubulin acetylation in triple-negative
breast cancer cells. Breast Cancer Res Treat 186: 37-51,
2021.
20210285
Oba T, Maeno K, Ono M, Ito T, Kanai T, Ito
K* : Prognostic Nutritional Index Is Superior to Neutrophilto-lymphocyte Ratio as a Prognostic Marker in Metastatic
Breast Cancer Patients Treated With Eribulin. Anticancer
Res 41: 445-452, 2021.
20210286
Oba T, maeno K, Amitani M, Shimizu T, Ohno
K, Ono M, Ito T, Kanai T, Uehara T, Ito K* : Prognostic
significance of neutrophil-to-lymphocyte ratio for longterm outcomes in patients with poorly differentiated thyroid
cancer. Endocr J 68: 1329-1336, 2021.
20210287
Oba T, Kajihara R, Yokoi T, Repaasky EA, Ito
K* : Neoadjuvant In Situ Immunomodulation Enhances
Systemic Antitumor Immunity against Highly Metastatic
Tumors. Cancer Res 81: 6183-6195, 2021.
20210288
Oba T, Makino K, Kajihara R, YokoiT, Araki
R, Masumi A, Miderman H, Chang AE, Odunsi K, Ito
F : In situ delivery of iPSC-derived dendritic cells withlocal radiotherapy generates systemic antitumor immunityand potentiates PD-L1 blockade in preclinical poorly
immunogenic tumor models. J Immunother Cancer 9:e002432, 2021.
20210289
Shimizu T, Oba T, Chino T, Soma A, Ono M, Ito
T, Kanai T, Maeno K, Sato Y, Uehara T, Ito K* : Papillary
thyroid microcarcinoma with lung metastases: a case reportand review of the literature. Thyroid Res 14: 15, 2021.
20210290
Patel A, Oba T,Kajihara R, Yokoi T, Abrams S,
Ito F : Multimodal Intralesional Therapy for Reshaping the
Myeloid Compartment of Tumors Resistant to Anti-PD-L1
Therapy via IRF8 Expression. J Immunol 207: 1298-1309,
2021.
20210291
Yokoi T, Oba T, Kajihara R, Abrams S, Ito
F : Multimodal Intralesional Therapy for Reshaping the
Myeloid Compartment of Tumors Resistant to Anti-PD-L1
Therapy via IRF8 Expression. Sci Rep 11: 21992, 2021.

Orthopaedic Surgery
20210292
Ikegami S*, Uehara M, Miyaoka Y, Kuraishi S,
Oba H, Munakata R, Takizawa T, Kamanaka T, Hatakenaka
T, Takahashi J : A Novel Technique for Cervical Microscopic
Foraminotomy Utilizing Spinous Process Splitting:Microscopic Mini-Open Foraminotomy. Spine Surg Relat
Res 5: 431-436, 2021.
20210293
Hisano K, Yoshida H, Kawase S, Mimura T,
Haniu H, Tsukahara T, Kurihara T, Matsuda Y, Saito N,
Uemura T : Abundant oleoyl-lysophosphatidylethanolamine
in brain stimulates neurite outgrowth and protects against
glutamate toxicity in cultured cortical neurons. J Biochem
170: 327-336, 2021.
20210294
Mimura T, Tsutsumimoto T, Yui M, TakahashiJ, Kuraishi S, Misawa H : Adjacent segment pathology
following posterior lumbar interbody fusion for lumbar
degenerative spondylolisthesis: a comparison between
minimally invasive and conventional open approach. Spine J
21: 1297-1302, 2021.
20210295
Ideta H, Yoshida K, Okamoto M*, Sasaki
J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A,
Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima
A, Kamanaka T, Takahashi J, Kato H, Saito N : Antitumor
Effect of Sclerostin against Osteosarcoma. Cancers (Basel)
13: 6015, 2021.
20210296
Nakano M, Nakamura Y*, Urano T, Miyazaki
A, Suzuki T, Watanabe K, Takahashi J, Shiraki M :Associations of Homocysteine Metabolism With the Riskof Spinal Osteoarthritis Progression in Postmenopausal
Women. J Clin Endocrinol Metab 106: 3428-3438, 2021.

2220210297
Nakano M, Yui H, Kikugawa S, Tokida R, Sakai
N, Kondo N, Endo N, Haro H, Shimodaira H, Suzuki T,
Kato H, Takahashi J, Nakamura Y* : Associations of LRP5
and MTHFR Gene Variants with Osteoarthritis Prevalencein Elderly Women: A Japanese Cohort Survey Randomly
Sampled from a Basic Resident Registry. Ther Clin Risk
Manag 17: 1065-1073, 2021.
20210298
Takasaka M, Kobayashi S, Usui Y, Haniu H,
Tsuruoka S, Aoki K*, Saito N* : Biokinetic Evaluationof Contrast Media Loaded Carbon Nanotubes Using aRadiographic Device. Toxics 9: 331, 2021.
20210299
Ikegami S, Uehara M*, Tokida R, Nishimura
H, Sakai N, Horiuchi H, Kato H, Takahashi J : Cervical
Spinal Alignment Change Accompanying Spondylosis
Exposes Harmonization Failure with Total Spinal Balance:
A Japanese Cohort Survey Randomly Sampled from a Basic
Resident Registry. J Clin Med 10: 5737, 2021.
20210300
Iwaasa T, Tensho K*, Koyama S, ShimodairaH, Horiuchi H, Saito N, Takahashi J : Clinical outcome ofa new remnant augmentation technique with anatomical
double-bundle anterior cruciate ligament reconstruction:
Comparison among remnant preservation, resection, andabsent groups. Asia Pac J Sports Med Arthrosc Rehabil
Technol 25: 22-29, 2021.
20210301
Outani H, Kobayashi E, Wasa J, Saito M,
Takenaka S, Hayakawa K, Endo M, Takeuchi A, Kobayashi
H, Kito M, Morii T, Imanishi J, Ueda T : Clinical Outcomesof Patients with Metastatic Solitary Fibrous Tumors:
A Japanese Musculoskeletal Oncology Group (JMOG)
Multiinstitutional Study. Ann Surg Oncol 28: 3893-3901,
2021.
20210302
Sakai D, Tanaka M, Takahashi J, Taniguchi
Y, Schol J, Hiyama A, Misawa H, Kuraishi S, Oba H,
Matsubayashi Y, Kato S, Sugawara R, Sato M, Watanabe M,
Takeshita K : Cobalt–chromium versus titanium alloy rods
for correction of adolescent idiopathic scoliosis based on
one-year follow-up: a multicenter, randomized clinical trial.
J Neurosurg Spine 34: 897-906, 2021.

3298, 2021.
20210305
Sato M, Mutai H, Yamamoto S, Tsukakoshi
D, Takeda S, Oguchi N, Ichimura H, Ikegami S, Wada Y,
Seto T, Horiuchi H : Decreased activities of daily living
at discharge predict mortality and readmission in elderly
patients after cardiac and aortic surgery: A retrospective
cohort study. Medicine (Baltimore) 100: e26819, 2021.
20210306
Kobayakawa T, Miyazaki A, Saito M, Suzuki
T, Takahashi J, Nakamura Y* : Denosumab versus
romosozumab for postmenopausal osteoporosis treatment.
Sci Rep 11: 11801, 2021.
20210307
Kito M, Okamoto M*, Aoki K, Tanaka A,
Komatsu Y, Suzuki S, Takazawa A, Yoshimura Y, Takahashi
J : Distal femoral impaction bone grafting in revision for
tumor endoprosthesis. Knee 29: 42-48, 2021.
20210308
Uehara M, Nakamura Y*, Suzuki T, Nakano M,
Takahashi J : Efficacy and Safety of Oral Ibandronate versus
Intravenous Zoledronic Acid on Bone Metabolism and Bone
Mineral Density in Postmenopausal Japanese Women with
Osteoporosis. J Clin Med 10: 5420, 2021.
20210309
Uehara M, Nakamura Y*, Suzuki T, Sakai
N, Takahashi J : Efficacy of denosumab therapy for a
12-year-old female patient with Williams syndrome withosteoporosis and history of fractures: a case report. J Med
Case Rep 15: 594, 2021.
20210310
Izumiya M, Haniu M, Ueda K, Ishida H, Ma
C, Ideta H, Sobajima A, Ueshiba K, Uemura T, Saito N, H,
Haniu H : Evaluation of MC3T3-E1 Cell Osteogenesis in
Different Cell Culture Media. Int J Mol Sci 22: 7752, 2021.
20210311
Nakamura M, Ueda K, Yamamoto Y, Aoki K,
Zhang M, Saito N*, Yudasaka M : Ibandronate-Loaded
Carbon Nanohorns Fabricated Using Calcium Phosphates
as a Mediator and Their Effects on Macrophages andOsteoclasts. ACS Appl Mater Interfaces 13: 3701-3712,
2021.

20210303
Uehara M*, Ikegami S, Kuraishi S, Oba H,
Takizawa T, Munakata R, Hatakenaka T, Kamanaka T,
Miyaoka Y, Takahashi J : Comparison of fusion versus nonfusion surgery for retro-odontoid pseudotumor with atlantoaxial subluxation. N Am Spine Soc J 6: 100064, 2021.

20210312
Kuroda C, Ajima K, Ueda K, Sobajima A,
Yoshida K, Kamanaka T, Sasaki J, Ishida H, Haniu H,
Okamoto M, Aoki K, Kato H, Saito N* : Isolated lymphatic
vessel lumen perfusion system for assessing nanomaterial
movements and nanomaterial-induced responses inlymphatic vessels. nano today 36: 101018, 2021.

20210304
Hirai T, Uehara M, Miyagi M, Takahashi S,
Nakashima H : Current Advances in Spinal Diseases of theElderly: Introduction to the Special Issue. J Clin Med 10:20210313
Ohba T, Oba H, Koyama K, Oda K, Tanaka
N, Fujita K, Haro H : Locomotive syndrome: Prevalence,
surgical outcomes, and physical performance of patients

23

treated to correct adult spinal deformity. J Orthop Sci 26:
678-683, 2021.
20210314
Iwakawa H*, Uchiyama S, Fujinaga Y, Hayashi
M, Komatsu M, Kato H, Takahashi J : Magnetic resonanceimaging of diffusion characteristics following collagenase
clostridium histolyticum injection in Dupuytren's
contracture. J Orthop Surg (Hong Kong) 29: 1-8, 2021.
20210315
Osawa R, Ikegami S*, Horiuchi H, Tokida R,
Kato H, Takahashi J : Osteoporosis Detection by Physical
Function Tests in Resident Health Exams: A Japanese Cohort
Survey Randomly Sampled from a Basic Resident Registry.
J Clin Med 10: 1896, 2021.
20210316
Uehara M*, Ikegami S, Kuraishi S, Oba
H, Takizawa T, Munakata R, Hatakenaka T, Koseki M,
Takahashi J : Pre-operative angle of trunk rotation in prone
position estimates postoperative correction results. Medicine(Baltimore) 100: e28445, 2021.
20210317
Banno T, Yamato Y, Oba H, Ohba T, Hasegawa
T, Yoshida G, Arima H, Oe S, Mihara Y, Ushirozako H,
Takahashi J, Haro H, Matsuyama Y : Preoperative Thoracic
Curve Magnitude and L4 end Vertebra were Risk Factors
for Subjacent Disc Wedging after Selective Thoracolumbar/
Lumbar Fusion with L3 as the Lowest Instrumented Vertebra
in Lenke type 5 Curve Patients. Spine (Phila Pa 1976) 46:
E878-E887, 2021.
20210318
Uehara M*, Ikegami S, Horiuchi H, Takahashi
J, Kato H : Prevalence and Related Factors of Low Back
Pain in the General Elderly Population: A Japanese CrossSectional Study Randomly Sampled from a Basic Resident
Registry. J Clin Med 10: 4213, 2021.
20210319
Kobayakawa T, Suzuki T, Nakano M, Saito
M, Miyazaki A, Takahashi J, Nakamura Y* : Real-world
effects and adverse events of romosozumab in Japaneseosteoporotic patients: A prospective cohort study. Bone Rep
14: 101068, 2021.
20210320
Tokida R, Uehara M, Nakano M, Suzuki T,
Sakai N, Ikegami S, Takahashi J, Nakamura Y*, Kato H :Reference values for bone metabolism in a Japanese cohort
survey randomly sampled from a basic elderly resident
registry. Sci Rep 11: 7822, 2021.
20210321
Koiwai H, Kamimura M, Nakamura Y*,
Takahasi J,Taguhi A : Same-side insufficiency fractures of
the tibia and femur after denosumab discontinuation: a casereport. Mod Rheumatol Case Rep 5: 178-181, 2021.

20210322
Momose T, Nakamura Y*, Nakano M, Maeda T,
Morioka S, Sobajima A, Nakatsuchi Y, Takahashi J, Nawata
M : Short- to Mid-Term Clinical Outcomes of PosteriorStabilized Cementless Total Knee Arthroplasty with
Trabecular Metal Components. Ther Clin Risk Manag 17:
809-816, 2021.
20210323
Banno T, Yamato Y, Oba H, Ohba T, Hasegawa
T, Yoshida G, Arima H, Oe S, Mihara Y, Ushirozako H,
Takahashi J, Haro H, Matsuyama Y : Should L3 be selected
as the lowest instrumented vertebra in patients with Lenke
type 5C adolescent idiopathic scoliosis whose lowest end
vertebra is L4?. J Neurosurg Spine 35: 330-339, 2021.
20210324
Uehara M*, Takahashi J, Ikegami S, Tokida
R, Nishimura H, Sakai N, Kato H : Spinal Deformity andthe Musculoskeletal Cohort Study of the General Older
Population. Shinshu Med J 69: 111-120, 2021.
20210325
Hisano K, Kawase S, Mimura T, Yoshida
H, Yamada H, Haniu H, Tsukahara T, Kurihara T,
Matsuda Y, Saito N, Uemura T : Structurally different
lysophosphatidylethanolamine species stimulate neurite
outgrowth in cultured cortical neurons via distinct G-proteincoupled receptors and signaling cascades. Biochem Biophys
Res Commun 534: 179-185, 2021.
20210326
Ohba T, Oba H, Oda K, Tanaka N, Haro H: Surgical Outcomes After Minimally Invasive Direct
Lateral Corpectomy with Percutaneous Pedicle Screws
for Osteoporotic Thoracolumbar Vertebral Collapse
with Neurologic Deficits in the Thoracolumbar Spine
Compared with Those After Posterior Spinal Fusion with
Vertebroplasty. Spine (Phila Pa 1976) 46: 1271-1278, 2021.
20210327
Uehara M*, Ikegami S, Kuraishi S, Oba H,
Takizawa T, Munakata R, Hatakenaka T, Takahashi J : Tenyear clinical and radiographic results of computer-assisted
cervical pedicle screw fixation combined with laminoplasty.
Interdisciplinary Neurosurgery 26: 101353, 2021.
20210328
Sugawara R, Takeshita K, Takahashi J, Arai
Y, Watanabe K, Yamato Y, Oba H, Matsumoto M : The
complication trends of adult spinal deformity surgery inJapan - The Japanese Scoliosis Society Morbidity andMortality survey from 2012 to 2017. J Orthop Sci 26: 533537, 2021.
20210329
Sugawara R, Takeshita K, Takahashi J, Arai
Y, Watanabe K, Yamato Y, Oba H, Matsumoto M : The
complication trends of pediatric spinal deformity surgery
in Japan - The Japanese Scoliosis Society Morbidity andMortality survey from 2012 to 2017. J Orthop Sci 26: 744-

24749, 2021.
20210330
Yasukawa S, Uehara M*, Suzuki T, Nakano M,
Kosho T, Nakamura Y*, Takahashi J : The First Experienceof Denosmab Therapy on Patients with Ehlers-Danlos
Syndrome and Osteoporosis: Detailed Observation of Two
Patients. Mod Rheumatol Case Rep 5: 377-383, 2021.
20210331
Oguchi N, Yamamoto S, Terashima S, Arai
R, Sato M, Ikegami S, Horiuchi H : The modified water
swallowing test score is the best predictor of postoperative
pneumonia following extubation in cardiovascular surgery:A retrospective cohort study. Medicine (Baltimore) 100:e24478, 2021.
20210332
Mimura T, Yamazaki H, Hayashi M, Isobe F,
Kitamura Y : The Predictive Factors of Displacement of
Adult Distal End Radius Fracture Treated with Casting. J
Hand Surg Asian Pac Vol 26: 525-534, 2021.
20210333
Shimodaira H, Hatakeyama A, Suzuki H,
Takada S, Murata Y, Sakai A, Uchida S : The prevalence
and risk factors of pubic bone marrow edema infemoroacetabular impingement and hip dysplasia. J Hip
Preserv Surg 8: 318-324, 2021.
20210334
Uehara M, Takahashi J*, Ikegami S, Tokida R,
Nishimura H, Sakai N, Kuraishi S, Horiuchi H, Kato H :Values for the Japanese Orthopaedic Association Back Pain
Evaluation Questionnaire in the general elderly population:
A Japanese cohort survey randomly sampled from a basic
resident registry. J Orthop Sci 26: 774-778, 2021.
20210335
Nakano M, Nakamura Y*, Miyazaki
A, Takahashi J : Zinc Pharmacotherapy for Elderly
Osteoporotic Patients with Zinc Deficiency in a ClinicalSetting. Nutrients 13: 1814, 2021.

Neurosurgery
20210336
Fujii Y, Hanaoka Y*, Ogiwara T, Koyama JI,
Horiuchi T : Pediatric Case of Life-Threatening Stroke
Caused by Reversible Cerebral Vasoconstriction Syndrome
with Spontaneous Cervical Internal Carotid Artery
Vasospasm: A Case Report. J Stroke Cerebrovasc Dis30(10): 106036, 2021.
20210337
Fujii Y, Ogiwara T*, Goto T, Kanaya K, Hara Y,
Hanaoka Y, Hardian RF, Hongo K, Horiuchi T : Microscopic
Navigation-Guided Fence Post Technique for Maximal
Tumor Resection During Glioma Surgery. World Neurosurg
151: E355-E362, 2021.

20210338
Fujii Y, Ogiwara T*, Yamazaki D, Hanaoka Y,
Horiuchi T : Late malignant transformation of anaplastic
meningioma 18 years after primary surgery: A case report. J
Clin Neurosci 86: 136-138, 2021.
20210339
Hanaoka Y*, Koyama JI, Ogiwara T, Horiuchi
T : Letter to the Editor Regarding "Distal Access Catheters
for Coaxial Radial Access for Posterior Circulation
Interventions". World Neurosurg 152: 237, 2021.
20210340
Hanaoka Y*, Koyama JI, Fujii Y, Ogiwara
T, Ito K, Horiuchi T : Bilateral Transradial Approach for
Coil Embolization of Basilar Artery Aneurysms Associatedwith an Unfavorable Vertebral Artery Anatomy : Initial
Experience with Role-sharing Technique. Clin Neuroradiol
31(3): 699-707, 2021.
20210341
Hanaoka Y*, Koyama JI, Yamazaki D, Ogiwara
T, Horiuchi T : The need for further study of microcatheter
behavior through the trans-cell approach using a Neuroform
Atlas stent. J Neuroradiol 48(5): 406-407, 2021.
20210342
H a n a o k a Y * , Ya m a z a k i D , K o y a m a J I ,Horiuchi T : Letter: Combined Transradial and Transfemoral
Approach Using a Compliant Balloon for Emboli Protection
at the Vertebral Artery During Subclavian Stenosis
Stenting: 2-Dimensional Operative Video. Oper Neurosurg(Hagerstown) 21(4): E399, 2021.
20210343
Hanaoka Y*, Koyama JI, Ogiwara T, Horiuchi
T : Letter: Lessons Learned After 760 Neurointerventions
via the Upper Extremity Vasculature: Pearls and Pitfalls.
Neurosurgery 89(4): E259-E260, 2021.
20210344
Hardian RF, Ogiwara T*, Sato A, Fujii Y,
Suzuki Y, Hanaoka Y, Miyata M, Kamiya K, Sasaki T,
Goto T, Hongo K, Horiuchi T : Comparison Between
Conventional Flash and Off-Response Intraoperative Visual
Evoked Potential Monitoring for Endoscopic Endonasal
Surgery. Oper Neurosurg (Hagerstown) 21(6): 516-522,
2021.
20210345
Hardian RF, Goto T, Kanaya K, Hara Y,
Fujii Y, Hanaoka Y, Horiuchi T, Hongo K : Intraoperative
Lumbar Muscle Motor Evoked Potential Monitoring
With Transcortical Stimulation. World Neurosurg 146:
e1126-e1133, 2021.
20210346
Hardian RF*, Hanaoka Y, Funato K, Agata M,
Ito K, Horiuchi T : Assessment of collateral venous flowusing temporary clip placement at ICG videoangiography.
Acta Neurochir (Wien) 163(9): 2533-2536, 2021.

25

20210347
Ito K : Letter to the Editor. Understanding theanatomy of the mater. J Neurosurg Spine 34: 348-350,
2021.
20210348
I n o m a t a Y, H a n a o k a Y * , K o y a m a J I ,Suzuki Y, Fujii Y, Ogiwara T, Horiuchi T : Endovascular
Revascularization with a Scoring Balloon for Carotid
In-Stent Restenosis : Case Report and Literature Review.
Clin Neuroradiol 31(4): 1199-1204, 2021.
20210349
Kanaya K*, Mitsuhashi T, Kiuchi T, Kobayashi
S : The Efficacy of Intraoperative Passive Language
Mapping for Glioma Surgery: A Case Report. Front Neurol
12: 652401, 2021.
20210350
Ndukuba K, Ogiwara T*, Nakamura T, Kamiya
K, Hanaoka Y, Horiuchi T, Ohaegbulam S, Hongo K :Surgical strategy for symptomatic pineal cyst: is endoscopit
third ventriculostomy necessary in addition to cyst
fenestration?. Nagoya J Med Sci 83(3): 627-633, 2021.
20210351
Ogiwara T*, Horiuchi T : Letter to the
Editor. How to reduce unsolicited patient complaints toneurosurgeons. J Neurosurg 134: 2010-2011, 2021.
20210352
Ogiwara T*, Suzuki Y, Hasegawa T, Nakamura
T, Fujii Y, Hanaoka Y, Ito K, Yokota A, Higashiyama F, Oya
F, Horiuchi T : Tailor-Made Endoscopic Surgical Strategy
for Severe Intraventricular Hemorrhage with Obstructive
Hydrocephalus. World Neurosurg 150: e771-e776, 2021.
20210353
Ogiwara T*, Hori T, Fujii Y, Nakamura T,
Suzuki Y, Watanabe G, Hanaoka Y, Goto T, Hongo K,
Horiuchi T : Effectiveness of the intraoperative magnetic
resonance imaging during endoscopic endonasal approach
for acromegaly. Pituitary 24(5): 690-697, 2021.
20210354
Ogiwara T*, Goto T, Fujii Y, Nakamura
T, Suzuki Y, Hanaoka Y, Ito K, Horiuchi T, Hongo K: Endoscopic Endonasal Approach in the Smart Cyber
Operating Theater (SCOT): Preliminary ClinicalApplication. World Neurosurg 147: e533-e537, 2021.
20210355
Ya m a z a k i D , H a n a o k a Y * , K o y a m a J I ,Ogiwara T, Horiuchi T : Transradial dual-balloon protection
system for subclavian artery stenting: "Balloon Switching"technique and literature review. Eur J Radiol 143: 109907,
2021.
20210356
Aoyama T, Ogiwara T*, Ito K, Miyaoka Y,
Fujii Y, Hanaoka Y, Hasegawa T, Watanabe G, Seguchi T,
Hongo K : Correlations Among Consistency, Computed
Tomography Values, and Histopathological Subtypes of

Spinal Meningioma. Acta Med Okayama 75(6): 713-718,
2021.
20210357
Inojie MO, Suzuki Y*, Tamada H, Ogihara
N, Inomata Y, Yako T, Ohaegbulam SC, Horiuchi T : Rare
sphenoid ridge intracranial mature teratoma in an adultfemale. Nagoya J Med Sci 83(2): 379-386, 2021.
20210358
Kubota Y, Hanaoka Y*, Koyama J, Fujii
Y, Ogiwara T, Ito K, Horiuchi T : T-Configuration Stent
Placement for Carotid BifurcationStenosis Co-Existing with
Ipsilateral Intracranial Stenosis:A Case Report and Literature
Review. J Stroke Cerebrovasc Dis 30(2): 105472, 2021.
20210359
K a n a m o r i M , Ta k a m i H , Ya m a g u c h i S ,Sasayama T, Yoshimoto K, Tominaga T, Inoue A, Ikeda N,
Kambe A, Kumabe T, Matsuda M, Tanaka S, Natsumeda
M, Matsuda KI, Nonaka M, Kurihara J, Yamaoka M,
Kagawa N, Shinojima N, Negoto T, Nakahara Y, Arakawa
Y, Hatazaki S, Shimizu H, Yoshino A, Abe H, Akimoto J,
Kawanishi Y, Suzuki T, Natsume A, Nagane M, Akiyama
Y, Keino D, Fukami T, Tomita T, Kanaya K, Tokuyama T,
Izumoto S, Nakada M, Kuga D, Yamamoto S, Anei R, Uzuka
T, Fukai J, Kijima N, Terashima K, Ichimura K, Nishikawa
R : So-called bifocal tumors with diabetes insipidus andnegative tumor markers: are they all germinoma?. Neuro
Oncol 23(2): 295-303, 2021.
20210360
Kanamori M, Takami H, Suzuki T, Tominaga
T, Kurihara J, Tanaka S, Hatazaki S, Nagane M, Matsuda
M, Yoshino A, Natsumeda M, Yamaoka M, Kagawa N,
Akiyama Y, Fukai J, Negoto T, Shibahara I, Tanaka K,
Inoue A, Mase M, Tomita T, Kuga D, Kijima N, Fukami T,
Nakahara Y, Natsume A, Yoshimoto K, Keino D, Tokuyama
T, Asano K, Ujifuku K, Abe H, Nakada M, Matsuda KI,
Arakawa Y, Ikeda N, Narita Y, Shinojima N, Kambe A,
Nonaka M, Izumoto S, Kawanishi Y, Kanaya K, Nomura
S, Nakajima K, Yamamoto S, Terashima K, Ichimura K,
Nishikawa R : Necessity for craniospinal irradiation ofgerminoma with positive cytology without spinal lesion
on MR imaging-A controversy. Neurooncol Adv 3(1): 1-8,
2021.

Dentistry & Oral Surgery
20210361
Koyama Y*, Ohmori N, Momose H, Kondo E,
Yamada S, Kurita H : Detection of swallowing disorders
using a multiple channel surface electromyography sheet; apreliminary study. J Dent Sci 16: 160-167, 2021.
20210362
Yamada S*, Kondo E, Hashidume M, Sakurai
A, Otagiri H, Matsumura N, Kubo K, Hakoyama Y, Yajima
J, Morioka M, Akahane Y, Anzai K, Goto K, Uehara T, Sakai

26

H, Kurita H : A retrospective investigation of minor risk
factors as prognostic predictors and treatment indications
in oral squamous cell carcinoma. J Dent Sci 16: 445-452,
2021.
20210363
Sakurai A, Yamada S*, Karasawa I, Kondo E,
Kurita H : Accuracy of a salivary examination kit for thescreening of periodontal disease in a group medical check-up(Japanese-specific health check-up). Medicine (Baltimore)
100: e24539, 2021.
20210364
Kawamoto M, Yamada S*, Gibo T, Kajihara
R, Nagashio S, Tanaka H, Yajima J, Takizawa A, Kondo
E, Sakai H, Kaneko T, Uehara T, Kurita H : Relationshipbetween dry mouth and hypertension . Clin Oral Investig 25:
5217-5225, 2021.
20210365
Yamada S, Koike K, Isomura Tanaka E Chikazu
D, Yamagata K, Iikubo M, Hino S, Hibi H, Katsura K,
Nakamura S, Nomura T, Mori Y, Tojyo I, Kanamura N,
Yamamori I, Aota K, Fujita S, Tanzawa H, Kurita H : The
effects of perioperative oral management on perioperative
serum albumin levels in patients treated surgically undergeneral anesthesia: A multicenter retrospective analysis inJapan . Medicine (Baltimore) 100: e25119, 2021.
20210366
Nishizaki H, Morimoto Y, Yamada S, Kurita
H, Tanaka A, Yamaguchi A, Miyata M, Yoshikawa H,
Yanamoto S, Imai Y : Awareness of Complications of
Dental Treatment in Patients Treated with Drugs Affecting
the Immune System: A Nationwide Questionnaire Survey of
Dental Practitioners in Japan. Acta Med Okayama 75: 115123, 2021.
20210367
Rokutanda S, Yamada S, Yanamoto S, Sakamoto
H, Omori K, Rokutanda H, Yoshimi T, Fujishita A, Morita Y,
Yoshida N, Umeda M : redisposing conditions for condylar
sag after intraoral vertical ramus osteotomy. Sci Rep 11(1):10463, 2021.
20210368
Hasegawa T, Ueda N, Yamada S, Kato S, Iwata
E, Hayashida S, Kojima Y, Shinohara M, Tojo I, Nakahara
H, Yamaguchi T, Kirita T, Kurita H, Shibuya Y, Soutome S,
Akashi M : Japanese Study Group of Co-operative Dentistrywith Medicine (JCDM) Denosumab-related osteonecrosis of
the jaw after tooth extraction and the effects of a short drug
holiday in cancer patients: A multicenter retrospective study.
Osteoporos Int 32(11): 2323-2333, 2021.
20210369
Kawamoto M, Tanaka H*, Sakurai A, Otagiri H,
Karasawa I, Yamada S, Kurita H : Exploration of correlationof oral hygiene and condition with influenza infection. PLoS
One 16(8): e0254981, 2021.

20210370
Naruse T, Yanamoto S, Otsuru M, Yamakawa
N, Kirita T, Shintani Y, Okura M, Ota Y, Yamada S, Kurita
H, Umeda M : Multicenter retrospective study of weekly
cetuximab plus paclitaxel for recurrent or metastatic oral
squamous cell carcinoma . Anticancer Res 41: 5785-5791,
2021.
20210371
Kajihara R, Amari K, Arai N, Nagashio S,
Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y,
Maejima D, Kawai Y, Ohhashi T : Water intake releases
serotonin from enterochromaffin cells in rat jejunal villi.
Pflugers Arch 473: 921-936, 2021.
20210372
Kurita H*, Motoki N, Inaba Y, Misawa Y,
Ohira S, Kanai M, Tsukahara T, Nomiyama T : Maternal
alcohol consumption and risk of offspring with congenital
malformation: the Japan Environment and Children's Study.
Pediatr Res 90(2): 479-486, 2021.
20210373
Shibazaki T, Motoki N, Misawa Y, Ohira S,
Inaba Y, Kanai M, Kurita H, Nakazawa Y, Tsukahara T,
Nomiyama T : Association between pesticide usage during
pregnancy and neonatal hyperbilirubinemia requiring
treatment: the Japan Environment and Children's Study.
Pediatr Res 89(6): 1565-1570, 2021.

Urology20210374
Gotoh D, Cao N, Alexandre EC, Saito T,
Morizawa Y, Hori S, Miyake M, Torimoto K, Fujimoto
K, Yoshimura N : Effects of low-dose insulin or asoluble guanylate cyclase activator on lower urinary tract
dysfunction in streptozotocin-induced diabetic rats. Life
Science 286: 120001, 2021.
20210375
Minagawa T*, Oguchi T, Saitou T, Fukazawa A,
Hashida I, Koiwai K, Iijima K, Kato H, Ogawa T, Ishizuka
O : Impact of low-dose tadalafil on adverse events after lowdose-rate brachytherapy for prostate cancer: A bi-center
randomized open-label trial. Int J Urol 28(4): 432-438, 2021.
20210376
Saito T, Gotoh D, Wada N, Tyagi P, Minagawa
T, Ogawa T, Ishizuka O, Yoshimura N : Time-dependent
progression of neurogenic lower urinary tract dysfunction
after spinal cord injury in the mouse model. Am J Physiol
Renal Physiol 321(1): F26-F32, 2021.
20210377
Saito T, Hitchens TK, Foley LM, Singh N,
Mizoguchi S, Kurobe M, Gotoh D, Ogawa T, Minagawa T,
Ishizuka O, Chermansky C, Kaufman J, Yoshimura N, Tyagi
P : Functional and histologic imaging of urinary bladder wallafter exposure to psychological stress and protamine sulfate.
Scientific Reports 11(1): 19440, 2021.

27

20210378
Suzuki T*, Minagawa T, Saito T, Nakagawa T,
Suzuki T, Furuhata M, Hosaka K, Ogawa T, Ishizuka O :Effect of oxybutynin patch versus mirabegron on nocturiarelated quality of life in female overactive bladder patients:
A multicenter randomized trial. Int J Urol 28(9): 944-949,
2021.
20210379
Takahashi S, Takei M, Asakura H, Gotoh M,
Ishizuka O, Kato K, Koyama M, Takeyama M, Tomoe
H, Yamanishi T, Yokoyama O, Yoshida M, Yoshimura Y,
Yoshizawa T : Clinical guidelines for female lower urinary
tract symptoms (second edition). Int J Urol 28(5): 474-492,
2021.
20210380
Matsuda H*, Minagawa T, Agatsuma H,
Uehara T, Utazu H, Ogawa T, Yoshida K, Ishizuka O :Pleural and pulmonary metastases from nonseminomatous
germ cell tumors successfully managed by extrapleuralpneumonectomy. IJU Case Rep 4(2): 89-91, 2021.

Ophthalmology
20210381
Hirano T*, Toriyama Y, Takamura Y, Sugimoto
M, Nagaoka T, Sugiura Y, Okamoto Fi, Saito M, Noda
K, Yoshida S, Ishibazawa A, Sawada O, Murata T : Treatand-extend therapy with aflibercept for diabetic macularedema: a prospective clinical trial. Jpn J Ophthalmol
65: 354-362, 2021.
20210382
Hirano T*, Toriyama Y, Takamura Y, Sugimoto
M, Nagaoka T, Sugiura Y, Okamoto F, Saito M, Noda K,
Yoshida S, Ishibazawa A, Sawada O, Murata T : Outcomesof a 2-year treat-and-extend regimen with aflibercept fordiabetic macular edema. Sci Rep 11: 4488, 2021.
20210383
Kakihara S*, Hirano T, Imai A, Kurenuma
T, Chiku Y, Murata T : Micropulse laser trabeculoplasty
under maximal tolerable glaucoma eyedrops: treatment
effectiveness and impact of surgical expertise. Int J
Ophthalmol 14: 388-392, 2021.

1005-1008, 2021.
20210386
Kakihara S*, Kurenuma T, Murata T : BranchRetinal Artery Occlusion with Prepapillary Macroaneurysm
Enlargement. Ophthalmol Retina 5: 1124, 2021.
20210387
Chiku Y, Hirano T*, Takahashi Y, Tuchiya
A, Nakamura M, Murata T : Evaluating posterior vitreous
detachment by widefield 23-mm swept-source opticalcoherence tomography imaging in healthy subjects. Sci Rep
11: 19754, 2021.
20210388
Kondo M, Noma H, Shimura M, Sugimoto M,
Matsui Y, Kato K, Saishin Y, Ohji M, Ishikawa H, Gomi F,
Iwata K, Yoshida S, Kusuhara S, Hirai H, Ogata N, Hirano
T, Murata T, Tsuboi K, Kamei M, Kinoshita T, Kuwayama
S, Hirano Y, Ohta M, Kimura K, Takayama K, Takeuchi M,
Takamura Y, Okamoto F, Mitamura Y, Terasaki H, Sakamoto
T, Group OBOJCRSJ : Background Factors Affecting Visual
Acuity at Initial Visit in Eyes with Central Retinal Vein
Occlusion: Multicenter Study in Japan. J Clin Med 10: 5619,
2021.
20210389
Akahane S, Hirano T*, Shu S, Murata T :Bilateral Adie's Pupil following Laser Treatment of the
Ischemic Peripheral Retina for Uveitis: A Case Report. Case
Rep Ophthalmol 12: 909-914, 2021.
20210390
S u g i m o t o M , S a m p a K , Ts u k i t o m e H ,Kato K, Matsubara H, Asami S, Sekimoto K, Kitano S,
Yoshida S, Takamura Y, Hirano T, Murata T, Shimizu
M , K i n o s h i t a T, K u s u h a r a S , S a w a d a O , O h j i M ,Yoshikawa R, Kimura K, Ishikawa H, Gomi F, Terasaki
H , K o n d o M , I k e d a T, O n B e h a l f O f T h e Wr i t i n g
Committee Of Japan-Clinical Retina STudy Group
J-Crest : Trends in the Prevalence and Progression of
Diabetic Retinopathy Associated with Hyperglycemic
Disorders during Pregnancy in Japan. J Clin Med
11: 165, 2021.

Otorhinolaryngology

20210384
Ta n a k a M , K a k i h a r a S , H i r a b a y a s h i K ,Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A,
Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei
Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T :Adrenomedullin-Receptor Activity-Modifying Protein 2
System Ameliorates Subretinal Fibrosis by Suppressing
Epithelial-Mesenchymal Transition in Age-Related Macular
Degeneration. Am J Pathol 191: 652-668, 2021.

20210391
Kurozumi M, Takumi Y, Uehara T, Suzuki T,
Ohya A, Shinagawa J, Miyagawa J, Tsukahara Y, Yamada
A, Tsukada K, Suzuki H, Fujinaga Y : Preoperative Arterial
Embolization to Avoid Intraoperative Bleeding during
Endoscopic Sinus Surgery for Organized Hematoma of theMaxillary Sinus: A Case Series and Literature Review. Interv
Radiol (Higashimatsuyama) 6: 102-107, 2021.

20210385
Kakihara S*, Hirano T, Matsuda Y, Takano D,
Imai A, Miyahara T, Murata T : Deposits on Retinal Surface
Seen on OCT in Ocular Amyloidosis. Ophthalmol Retina 5:20210392
Kasuga M, Yoshimura H*, Shinagawa J, Nishio
SY, Takumi Y, Usami SI : Frequency and natural courseof congenital cytomegalovirus-associated hearing loss in28children. Acta Otolaryngol 141: 1038-1043, 2021.
20210393
Uchida Y, Mise K, Suzuki D, Fukunaga Y,
Hakuba N, Oishi N, Ogawa T, Takahashi M, Takumi Y,
Fujimoto S, Maeda Y, Nishizaki K, Noda T, Komune
N, Matsumoto N, Nakagawa T, Nishita Y, Otsuka R,
Maegawa A, Kimizuka T, Miyata A, Gonda A, Ishikawa K,
Higashino Y, Murakami S : A Multi-Institutional Study ofOlder Hearing Aids Beginners-A Prospective Single-Arm
Observation on Executive Function and Social Interaction. J
Am Med Dir Assoc 22: 1168-1174, 2021.
20210394
Yoshimura H, Nishio SY, Usami SI : Milestones
toward cochlear gene therapy for patients with hereditary
hearing loss. Laryngoscope Investig Otolaryngol 6: 958-967,
2021.
20210395
Yoshimura H, Nishio SY, Isaka Y, Kurokawa
T, Usami SI : A nationwide epidemiologic, clinical, genetic
study of Usher syndrome in Japan. Acta Otolaryngol 141:841-846, 2021.
20210396
Yo s h i m u r a H , Ta k a h a s h i M , I w a s a k i S ,Shinagawa J, Takashimizu I, Nagai F, Yotsuyanagi T, Usami
SI : Vibrant soundbridge implantation prior to auricular
reconstruction with unilateral microtia-atresia. Clin Case
Rep 9: e04408, 2021.

Fujinaga Y : Useful preoperative examination findings
to classify the grade of ovarian primary mucinous tumor.
Abdom Radiol (NY) 46: 2393-4202, 2021.
20210402
Yamada Y, Miyamoto T*, Higuchi S, Ono M,
Kobara H, Asaka R, Ando H, Suzuki A, Shiozawa T : cDNA
expression library screening revealed novel functional genes
involved in clear cell carcinogenesis of the ovary in vitro. J
Obstet Gynaecol 41: 100-105, 2021.
20210403
Youngran Park, Jin-Gyoung Jung, Zheng-Cheng
Yu, Asaka R, Wenjing Shen, Yeh Wang, Wei-Hung Jung,
Alicja Tomaszewski, Geoff Shimberg, Yun Chen, Vamsi
Parimi, Stephanie Gaillard, Ie-Ming Shih, Tian-Li Wang :A novel human endometrial epithelial cell line for modelinggynecological diseases and for drug screening. La b Invest
101: 1505-1512, 2021.
20210404
Shibazaki T, Noriko M, Misawa Y, Ohira S,
Inaba Y, Kanai M, Kurita H, Nakazawa Y, Tsukahara T,
Nomiyama T and the Japan Environment & Children’s
Study (JECS) Group : Association between pesticide usage
during pregnancy and neonatal hyperbilirubinemia requiring
treatment: the Japan Environment and Children’s Study.
Pediatric Research 89: 1565-1570, 2021.

Anesthesiology and Resuscitology

20210397
Tsukada K, Usami SI : Vestibular nerve
deficiency and vestibular function in children with unilateral
hearing loss caused by cochlear nerve deficiency. Acta
Otolaryngol. 141: 835-840, 2021.

20210405
Yoshiyama Y, Sugiyama Y*, Ishida K, Fuseya
S, Tanaka S, Kawamata M : Plantar incision with severe
muscle injury can be a cause of long-lasting postsurgical
pain in the skin. Life Sciences 275: 119389, 2021.

20210398
Tsukada K, Usami SI : Vestibular Preservation
After Cochlear Implantation Using the Round Window
Approach. Front Neurol 12: 656592, 2021.

20210406
Tanaka R*, Tanaka S, Hayashi K, Iida K, Sawa
T, Kawamata M : The histamine H1 receptor antagonist
hydroxyzine enhances sevoflurane and propofol anesthesia:
A quantitative EEG study. Clinical Neurophysiology 132:2054-2061, 2021.

20210399
Hiramatsu K, Nishio SY, Kitajiri SI, Kitano
T, Moteki H, Usami SI, On Behalf Of The Deafness Gene
Study Consortium : Prevalence and Clinical Characteristics
of Hearing Loss Caused by MYH14 Variants. Genes 12:1623, 2021.

Obstetrics and Gynecology

20210407
Ide S, Arai N, Morimitsu N, Momose H,
Hayashi M, Watanabe‑Asaka T, Ishida T, Tanaka S, Seto T,
Kawai Y, Kawamata M, Ohhashi T : Another route of CO2
gas excretion independent of red blood cells in human lungs.
European Journal of Physiology 473(10): 1657-1666, 2021.

20210400
Ohya A, Kobara H, Miyamoto T, Komatsu M,
Shiozawa T, Fujinaga Y : Usefulness of the 'cosmos pattern'for differentiating between cervical gastric-type mucinpositive lesions and other benign cervical cystic lesions inmagnetic resonance images. J Obstet Gynaecol Res 47: 745756, 2021.

20210408
Takazawa T, Sugiyama Y, Amano Y, Hara T,
Kanemaru E, Kato T, Kawano T, Kochiyama T, Tsuji T, Saito
S : Impact of the First Wave of COVID-19 on the Number ofGeneral Anesthesia Cases in 34 Tertiary Hospitals in Japan:
A Multicenter Retrospective Study. Anesthesiology Researchand Practice 2021: 8144794, 2021.

20210401

Ohya A, Ichinohe F, Matoba H, Kobara H,

2920210409
Sugiyama Y*, Aiba K, Arai N, Ito M, Urasawa
M, Hirose C, Murakami I, Tanaka R, Yamada T, Iida K,
Nakamura H, Kawamata M : Successful management of apatient with intraoperative bleeding of more than 80,000 mL
and usefulness of QTc monitoring for calcium correction.
Case reports in Anesthesiology 2021: 6635696, 2021.
20210410
Kondo N, Kasamatsu H, Nakazawa H, Tanaka
H, Kimura Kuroiwa K, Ide S : Is That a Real Tumor?.
Journal of Cardiothoracic and Vascular Anesthesia 35(8):2530-2532, 2021.
20210411
Sugiyama Y*, Numata K, Watanabe N, Urasawa
M, Murakami T, Murakami I, Koyama JI, Kawamata M: Catheter-induced anaphylaxis and determination of thecausative catheter in a patient undergoing neuroendovascularsurgery: a case report. JA Clin Rep 7: 59, 2021.

prospective comparison of the Baxter and Modified Brooke
formulas for acute burn resuscitation. Burns Open 5: 89-95,
2021.
20210418
Hosomi K, Yuzuriha S, Yanagisawa D : Buried
patch skin grafting under granulation flap for impaired
wounds with local and general severe complications. Int J
Surg Wound Care 2: 84-89, 2021.
20210419
Ishii T, Takashimizu I, Martin Micuel CascoRobles, Taya Y, Yuzuriha S, Toyama F, Maruo F, Kishi K,
Chiba C : Skin Wound Healing of the Adult Newt, Cynops
pyrrhogaster: A Unique Re-Epithelialization and Scarless
Model. Biomedicines 9: 1892, 2021.

Plastic and Reconstructive Surgery

20210420
Minatogawa M, Tsukahara Y, Yuzuriha S,
Kosho T : Detailed clinical and radiological features of thefirst patient with Elsahy-Waters syndrome in East Asia. Am J
Med Genet A 185: 3909-3915, 2021.

20210412
Tsunekawa K*, Nagai F, Kato T, Takashimizu
I, Yanagisawa D, Yuzuriha S : Hallucal thenar index: a newindex to detect peripheral arterial disease using laser speckle
flowgraphy. Vascular 29: 100-107, 2021.

20210421
Nakajima Y, Iwasawa M, Mishima Y : Subtotal
Nasal Reconstruction in a 91-year-old Patient: Expanded
Double Forehead Flaps and Costal Cartilage. Plast Reconstr
Surg Glob Open 15: e3868, 2021.

20210413
I w a s a w a M , K a w a m u r a T, Yu z u r i h a S :Pharmacological flap thinning with local injection oftriamcinolone acetonide. J Plast Reconstr Aesthet Surg 74:
2392-2442, 2021.

20210422
Suito M, Abe N, Hirasawa C, Aisaka T, Sakai H: Reconstruction of Completely Circumferentially Degloved
Thumb Using Omental Flap and Tubular Split-thickness
Skin Graft. Plast Reconstr Surg Glob Open 9: e3901, 2021.

20210414
Yasunaga Y, Nakajima Y, Mimura S, Yuzuriha
S, Kondoh S : Magnetic resonance lymphography as threedimensional navigation for lymphaticovenular anastomosis
in patients with leg lymphedema. J Plast Reconstr Aesthet
Surg 74: 1253-1260, 2021.

Laboratory Medicine

20210415
Yasunaga Y, Nakajima Y, Mimura S, Kobayashi
M, Yuzuriha S, Kondoh S : Extracellular Water Ratioas an Indicator of the Development and Severity of Leg
Lymphedema Using Bioelectrical Impedance Analysis.
Lymphat Res Biol 19: 223-230, 2021.
20210416
Ts u n e k a w a K * , K o n d o h S , N o g u c h i M ,Yuzuriha S, Iwasawa M : Aesthetic outcomes following
adipose flap versus fillet flap technique for radial
polydactyly: a comparison study. J Hand Surg Eur 46: 378383, 2021.
20210417
Saitoh D, Gando S, Maekawa K, Sasaki J,
Fujishima S, Ikeda H, Shiino Y, Takuma K, Nakada T,
Tanaka K, Tasaki O, Nemoto M, Yuzuriha S, Yamaguchi H,
Iwase F, Matsuyama S, Matsui K, Yoshimuta K, Yamamura
H, Harunari N, Okamoto K, Tanaka H : A randomized

20210423
Iwaya M*, Hayashi H, Nakajima T, Matsuda K,
Kinugawa Y, Tobe Y, Tateishi Y, Iwaya Y, Uehara T, Ota H: Colitis-associated colorectal adenocarcinomas frequently
express claudin 18 isoform 2: implications for claudin 18.2
monoclonal antibody therapy. Histopathology 79: 227-237,
2021.
20210424
K a n a z a w a H , S a s a k i N , K o b a y a s h i T,
Fukushima T, Kanda S, Koizumi T, Iwaya M : Direct
Intraesophageal Growth from Metastatic Mediastinal
Lymphadenopathy in Thymic Carcinoma. Intern Med 60:
923-926, 2021.
20210425
Iwaya M*, Ota H, Nakajima T, Uehara T,
Riddell R, Conner J : Most colitis associated carcinomas
lack expression of LGR5: a preliminary study with
implications for unique pathways of carcinogenesis
compared to sporadic colorectal carcinoma. BMC Cancer
21: 119, 2021.
20210426

Yamazaki H, Fujimoto K : A new noninvasive

30

method for measurement of dynamic lung compliance fromfluctuations on photoplethysmography in respiration. J Appl
Physiol 130: 215-225, 2021.
20210427
Nakajima H, Maeno K, Ito T, Kanai T, Oba T,
Ono M, Takayama F, Uehara T, Ito KI : Concomitant useof 18F-FDG PET-CT SUVmax is useful in the assessmentof Ki67 labeling index in core-needle biopsy specimens ofbreast cancer. Gland Surg 10: 1-9, 2021.
20210428
Kawamoto M, Yamada SI, Gibo T, Kajihara
R, Nagashio S, Tanaka H, Yajima J, Takizawa A, Kondo
E, Sakai H, Kaneko T, Uehara T, Kurita H : Relationshipbetween dry mouth and hypertension. Clin Oral Investig 25:
5217-5225, 2021.
20210429
Uchino K, Notohara K, Uehara T, Kuraishi
Y, Itakura J, Matsukawa A : Utility of gastric biopsy indiagnosing IgG4-related gastrointestinal disease. Pathol Int
71: 124-134, 2021.
20210430
Tsukahara Y, Okajima Y, Yamada A, Momose
M, Uehara T, Shimizu A, Soejima Y, Fujinaga Y : The
peritumoral hypointense rim around hepatocellular
carcinoma on T2*-weighted magnetic resonance imaging:radiologic-pathologic correlation. World J Surg Oncol 19:41, 2021.
20210431
Koyama T, Shimizu K, Uehara T, Matsuoka
S, Takeda T, Yamada K, Eguchi T, Hamanaka K, Sano K :Synchronous triple primary lung cancer with three different
histological subtypes in the same lobe: A case report. Thorac
Cancer 12: 711-714, 2021.
20210432
Oba T, Ono M, Matoba H, Uehara T, Hasegawa
Y, Ito KI : HDAC6 inhibition enhances the anti-tumor effectof eribulin through tubulin acetylation in triple-negative
breast cancer cells. Breast Cancer Res Treat 186: 37-51,
2021.
20210433
Yamada SI, Kondo E, Hashidume M, Sakurai A,
Otagiri H, Matsumura N, Kubo K, Hakoyama Y, Yajima J,
Morioka M, Akahane Y, Anzai K, Goto K, Uehara T, Sakai
H, Kurita H : A retrospective investigation of minor risk
factors as prognostic predictors and treatment indications inoral squamous cell carcinoma. J Dent Sci 16: 445-452, 2021.
20210434
Hori A, Ishida F, Nakazawa H, Yamaura
M, Morita S, Uehara T, Honda T, Hidaka H* : Serum
sphingomyelin species profile is altered in hematologic
malignancies. Clin Chim Acta 514: 29-33, 2021.
20210435

Ogawa A, Watanabe T, Natsume T, Okura E,

Saito S, Kato S, Nakayama Y, Furukawa S, Yamaguchi T,
Kosho T, Uehara T, Kobayashi N, Agematsu K, Nakazawa
Y, Shigemura T : Early-Onset Inflammatory Bowel Disease
Caused by Mutations in the X-Linked Gene IL2RG. J
Investig Allergol Clin Immunol 31: 69-71, 2021.
20210436
Konno S, Yanagisawa R, Motoki N, Shimodaira
S : Predictive factors of poor blood collecting flow during
leukocyte apheresis for cellular therapy. Ther Apher Dial 25:
1001-1011, 2021.
20210437
Sogawa K, Kiyosuke M, Hattori K, Murata S,
Watari T, Kusaba K, Saeki Y, Horiuchi K, Yasuda K, Uechi
K, Okumura H, Sekiguchi S, Fujinaga A, Murakami M,
Nakayama T : Examination of conditions for regular internal
quality control in identification of microorganisms using
MALDI-TOF MS. Biocontrol Sci 26: 99-104, 2021.
20210438
Kaido T, Yoda M, Kamijo T, Arai S, Yamauchi
K, Okumura N : A novel variant fibrinogen, AαE11del,demonstrating the importance of AαE11 residue in thrombin
binding. Int J Hematol 114: 591-598, 2021.
20210439
Hasegawa A, Saito S, Narimatsu S, Nakano S,
Nagai M, Ohnota H, Inada Y, Morokawa H, Nakashima I,
Morita D, Ide Y, Matsuda K, Tashiro H, Yagyu S, Tanaka
M, Nakazawa Y : Mutated GM-CSF-based CAR-T cells
targeting CD116/CD131 complexes exhibit enhanced antitumor effects against acute myeloid leukaemia. Clin Transl
Immunology 10: e1282, 2021.
20210440
Kamijo T, Kaido T, Yoda M, Arai S, Yamauchi
K, Okumura N : Recombinant γY278H Fibrinogen Showed
Normal Secretion from CHO Cells, but a Corresponding
Heterozygous Patient Showed Hypofibrinogenemia. Int J
Mol Sci 22: 5218, 2021.
20210441
Ehara T, Uehara T*, Nakajima T, Kinugawa
Y, Kobayashi S, Iwaya M, Ota H, Soejima Y : LGR5
expression is associated with prognosis in poorly
differentiated gastric adenocarcinoma. BMC Cancer 21: 228,
2021.
20210442
M a t s u d a H , M i n a g a w a T, A g a t s u m a H ,Uehara T, Utazu H, Ogawa T, Yoshida K, Ishizuka O :Pleural and pulmonary metastases from nonseminomatous
germ cell tumors successfully managed by extrapleuralpneumonectomy. IJU Case Rep 4: 89-91, 2021.
20210443
Komatsu M, Yamamoto H, Kitaguchi Y,
Kawakami S, Matsushita M, Uehara T, Kinjo T, Wada Y,
Ichiyama T, Urushihata K, Ushiki A, Yasuo M, Hanaoka
M : Clinical characteristics of non-idiopathic pulmonary

31

fibrosis, progressive fibrosing interstitial lung diseases: A
single-center retrospective study. Medicine (Baltimore) 100:
e25322, 2021.

Umemura T : Impact of DNA double-strand breaks onpancreaticobiliary maljunction carcinogenesis. Diagn Pathol
16: 72, 2021.

20210444
Sato K, Uehara T*, Nakajima T, Iwaya M,
Miyagawa Y, Watanabe T, Ota H : Inverse correlation
between PD-L1 expression and LGR5 expression in tumor
budding of stage II/III colorectal cancer. Ann Diagn Pathol
52: 151739, 2021.

20210452
Miura K, Shimizu K, Ide S, Mishima S,
Matsuoka S, Takeda T, Eguchi T, Hamanaka K, Uehara T : A
Novel Strategy for the Diagnosis of Pulmonary High-Grade
Neuroendocrine Tumor. Diagnostics (Basel) 11: 1945, 2021.

20210445
Hanafusa H, Hidaka Y, Yamaguchi T, Shimojo
H, Tsukahara T, Murase T, Matsuoka D, Chiba N, Shimada
S, Morokawa H, Omori N, Minoura H, Nagano C, Takano
K, Nakamura K, Wakui K, Fukushima Y, Uehara T,
Nakazawa Y, Iijima K, Nozu K, Kosho T : Heterozygous
missense variant in TRPC6 in a boy with rapidly progressive
infantile nephrotic syndrome associated with diffuse
mesangial sclerosis. Am J Med Genet A 185: 2175-2179,
2021.
20210446
Shimizu T, Oba T, Chino T, Soma A, Ono M,
Ito T, Kanai T, Maeno K, Sato Y, Uehara T, Ito KI : Papillary
thyroid microcarcinoma with lung metastases: a case reportand review of the literature. Thyroid Res 14: 15, 2021.
20210447
Miura K, Shimizu K, Eguchi T, Koike S,
Matsuoka S, Takeda T, Hamanaka K, Uehara T : Usefulness
of SS18-SSX antibody as a diagnostic marker for pulmonary
metastatic synovial sarcoma. Diagn Pathol 16: 54, 2021.
20210448
Hori Y, Chari ST, Tsuji Y, Takahashi N, Inoue
D, Hart PA, Uehara T, Horibe M, Yamamoto S, Satou A,
Zhang L, Notohara K, Naitoh I, Nakazawa T : Diagnosing
Biliary Strictures: Distinguishing IgG4-Related Sclerosing
Cholangitis From Cholangiocarcinoma and Primary
Sclerosing Cholangitis. Mayo Clin Proc Innov Qual
Outcomes 5: 535-541, 2021.

20210453
Morikawa H, Nobuoka M, Amitani M, Shimizu
T, Ohno K, Ono M, Oba T, Ito T, Kanai T, Maeno K, Uehara
T, Ito KI : Fibroadenoma in a young male breast: A casereport and review of the literature. Clin Case Rep 9: e05114,
2021.
20210454
Ya m a d a H , F u k u s h i m a T, K o b a y a s h i T,
Kanda S, Koizumi T, Iwaya M : Successful Response
to Cyclophosphamide, Vincristine, and Dacarbazine
Chemotherapy in a Patient with Metastatic Carotid Body
Paraganglioma. Case Rep Oncol 14: 1827-1833, 2021.
20210455
Kobayashi R, Shimizu A, Kubota K, Notake
T, Sugenoya S, Hosoda K, Hayashi H, Yasukawa K, SatohY, Iwaya M, Sano K, Soejima Y : Maffucci Syndrome with
Intrahepatic Cholangiocarcinoma: A Case Report. Case Rep
Oncol 14: 1347-1352, 2021.
20210456
Tsuchiya T, Iwaya Y, Iwaya M, Okamura T,
Nagaya T, Umemura T. : A Case of Multiple Perineuriomas
in the Colon With Underlying Neurofibromatosis Type I.
ACG Case Rep J 8: e00665, 2021.
20210457
Shimizu T, Hondo N, Miyagawa Y, Kitazawa
M, Muranaka F, Tokumaru S, Nakamura S, Koyama M,
Yamamoto Y, Ehara T, Miyazaki S, Iijima Y, Iwaya M,
Soejima Y : A case of appendiceal ganglioneuroma inneurofibromatosis type 1. Surg Case Rep 7: 218, 2021.

20210449
Oba T, Maeno K, Amitani M, Shimizu T, Ohno
K, Ono M, Ito T, Kanai T, Uehara T, Ito KI : Prognostic
significance of neutrophil-to-lymphocyte ratio for longterm outcomes in patients with poorly differentiated thyroid
cancer. Endocr J 68: 1329-1336, 2021.

20210458
Kako S, Iwaya Y, Nagaya T, Hara D, Okamura
T, Iwaya M, Kurasawa S, Kato S, Nakayama Y, Akamatsu
T, Umemura T : Clinicopathological features of nodular
gastritis in three classes of age. Helicobacter 26: e12845,
2021.

20210450
Hoshino H, Akama TO, Uchimura K,
Fukushima M, Muramoto A, Uehara T, Nakanuma Y,
Kobayashi M : Apical Membrane Expression of Distinct
Sulfated Glycans Is a Characteristic Feature of Ductules andTheir Reactive and Neoplastic Counterparts. J Histochem
Cytochem 69: 555-573, 2021.

20210459
Kudo T, Horiuchi A, Kyodo R, Tokita K,
Tanaka N, Horiuchi I, Sano K : Mucosal defect size predicts
the adequacy of resection of ≤10 mm nonpedunculatedcolorectal polyps using a new cold snare polypectomy
technique. Eur J Gastroenterol Hepatol 33: e484-e489, 2021.

20210451
Kuraishi Y, Uehara T*, Muraki T, Iwaya
M, Kinugawa Y, Nakajima T, Watanabe T, Miyagawa Y,

20210460
Kurozumi M, Takumi Y, Uehara T, Suzuki T,
Ohya A, Shinagawa J, Miyagawa J, Tsukahara Y, Yamada
A, Tsukada K, Suzuki H, Fujinaga Y : Preoperative Arterial

32

Embolization to Avoid Intraoperative Bleeding during
Endoscopic Sinus Surgery for Organized Hematoma of theMaxillary Sinus: A Case Series and Literature Review. Interv
Radiol (Higashimatsuyama) 6: 102-107, 2021.
20210461
Yamaguchi M, Koizumi T, Sugano M : Impact
of short-term storage of plasma samples on quantitationof ultra-low levels of interleukin-6. J Int Med Res 49:
3000605211056846, 2021.
20210462
Ota H, Ito M, Kobayashi C, Asaka S, Iwaya M,
Uehara T : Superiority of sucrase-isomaltase to CD10 for
immunohistochemical detection of intestinal absorptive cell
phenotype in differentiated-type gastric adenocarcinoma. Int
J Clin Exp Pathol 14: 1031-1037, 2021.
20210463
Matsumoto T*, Matsumoto-Matsubara M,
Horiuchi K, Arai E, Negishi T, Natori T, Kawakami
Y : Antibiotic resistance and the presence of bla CfxA
and bla CSP genes in β-lactamase-producing clinicalCapnocytophaga isolates from a university hospital in Japan.
J Med Microbiol 70: 001448, 2021.
20210464
Arai S, Kamijo T, Kaido T, Yoda M, Shinohara
S, Suzuki T, Arai N, Sugano M, Uehara T, Okumura N: Automated screening procedure for the phenotypes ofcongenital fibrinogen disorders using novel parameters,|min1|c and Ac/|min1|c, obtained from clot waveform
analysis using the Clauss method. Clin Chim Acta 521: 170176, 2021.
20210465
Yoda M, Kaido T, Kamijo T, Taira C, Higuchi
Y, Arai S, Okumura N : Novel variant fibrinogen γp.C352R
produced hypodysfibrinogenemia leading to a bleeding
episode and failure of infertility treatment. Int J Hematol
114: 325-333, 2021.
20210466
Tsukadaira T, Hayashi S, Ota H, Kobayashi N,
Sekiguchi Y, Kodaira H, Matsumoto T, Horiuchi K, Negishi
T, Kurahashi M : Acute gastric mucosal lesions caused byacute infection of non-Helicobacter pylori Helicobacter: acase report. Helicobacter 26: e12814, 2021.
20210467
Tsukadaira T, Hayashi S, Ota H, Kobayashi
N, Sekiguchi Y, Kodaira H, Matsumoto T, Horiuchi K,
Negishi T, Kurahashi M : Prevalence, clinical features,and esophagogastroduodenoscopy (EGD) findings of nonHelicobacter pylori Helicobacter infection: A study of 50
cases at a single facility in Japan. Helicobacter 26: e12811,
2021.
20210468
Joshita S, Yamashita Y, Okamoto T, Usami Y,
Sugiura A, Yamazaki T, Kakino A, Ota M, Sawamura T,

Umemura T : Quantitative and qualitative lipid improvementwith chronic hepatitis C virus eradication using direct-acting
antivirals. Hepatol Res 51: 758-766, 2021.
20210469
S h i g e m u r a T, M a r u y a m a Y, S h i g e t o S ,Nakazawa Y, Kanno H : Orbital Epstein-Barr virus-related
post-transplant lymphoproliferative disorder in a 13-year-old
girl with cord blood transplantation. Transpl Infect Dis 23:
e13536, 2021.
20210470
Hayashi W, Iimura M, Horiuchi K, Arai E,
Natori T, Suzuki S, Matsumoto G, Izumi K, Yoshida
S, Nagano Y, Nagano N : Occurrence of blaNDM-1
in a Clinical Isolate of Acinetobacter lwoffii in Japan:
Comparison of blaNDM-1-Harboring Plasmids between A.
lwoffii and A. pittii Originated from a Hospital Sink. Jpn J
Infect Dis 74: 252-254, 2021.
20210471
Inojie MO, Suzuki Y, Tamada H, Ogihara N,
Inomata Y, Yako T, Ohaegbulam SC, Horiuchi T : Rare
sphenoid ridge intracranial mature teratoma in an adultfemale. Nagoya J Med Sci 83: 379-386, 2021.
20210472
Sano K*, Asahina M, Uehara T, Araki N,
Yamanaka Y, Matsumoto K, Okuyama R : Clear cell injury
associated with reduced expression of carbonic anhydrase
II in eccrine glands consistently occurs in patients withacquired idiopathic generalized anhidrosis. J Dermatol 48:
439-446, 2021.
20210473
Arai S, Kamijo T, Hayashi F, Shinohara S,
Arai N, Sugano M, Uehara T, Honda T, Okumura N :Screening method for congenital dysfibrinogenemia using
clot waveform analysis with the Clauss method. Int J Lab
Hematol 43: 281-289, 2021.
20210474
Usami Y, Sugano M, Uehara T*, Koinuma M,
Ishimine N, Kawasaki K, Yamauchi K, Hamano H, Honda
T : Cut-off values of serum IgG4 among three reagents,
including a novel IgG4 reagent: a multicenter study. Sci Rep
11: 7280, 2021.
20210475
Bergsma AJ, In 't Groen SLM, Catalano F,
Yamanaka M, Takahashi S, Okumiya T, van der Ploeg AT,
Pijnappel WWMP : A generic assay for the identificationof splicing variants that induce nonsense-mediated decay in
Pompe disease. Eur J Hum Genet 29: 422-433, 2021.
20210476
Ichimata S, Katoh N, Abe R, Yoshinaga T,
Kametani F, Yazaki M, Uehara T, Sekijima Y : A case ofnovel amyloidosis: glucagon-derived amyloid deposition
associated with pancreatic neuroendocrine tumour. Amyloid
28: 72-73, 2021.

33

20210477
Nishina S, Sakai H, Kawakami T, Kanai S,
Ushiki A, Natori T, Igarashi Y, Mitarai S, Yoshiyama T,
Ishida F, Nakazawa H : Isolated splenic Mycobacterium
tuberculosis complex infection in an immunocompetent
individual with FDG-PET positive mass. J Infect Chemother27: 354-358, 2021.
20210478
Fujimura S, Higuchi Y, Usami Y, Yamaura M,
Higuchi T, Terasawa F, Okumura N : Changes in serum
citrullinated fibrinogen concentration associated with thephase of bacteremia patients. Clin Chim Acta 512: 127-134,
2021.

Emergency and Critical Care Medicine
20210479
Imamura H*, Kashima Y, Hattori M, Mori K,
Takeshige K, Nakazawa H : Unexplained recurrent shock inperipheral T-cell lymphoma: A case report. Clin Case Rep
10: e04612, 2021.
20210480
Mochizuki K*, Fujii T, Paul E, Anstey M,
Pilcher DV, Bellomo R : Early metabolic acidosis in
critically ill patients: a binational multicentre study. Crit
Care Resusc 23: 67-75, 2021.
20210481
Mochizuki K*, Fujii T, Paul E, Anstey M :Acidemia subtypes in critically ill patients: An international
cohort study. J Crit Care 64: 10-17, 2021.
20210482
Nitta K*, Imamura H, Miyama H, Mori K,
Hamano Y, Mochizuki K, Kamijo H, Ichikawa M, Takeshige
K, Kashima Y : A retrospective analysis of 30 patients withspontaneous spinal epidural hematoma. Interdisciplinary
Neurosurgery 25: 101216, 2021.
20210483
Kameyama A, Imamura H, Kamijo H,
Takeshige K, Mochizuki K, Nitta K* : Diagnostic Pitfalls
in Papillary Muscle Rupture-Associated Acute Mitral
Regurgitation after Acute Myocardial Infarction. Case Rep
Crit Care 2021: 1396194, 2021.
20210484
Uchida M, Kashima Y*, Mochizuki K,
Sakamoto H, Mori K, Ebisawa S, Takeshige K, Nitta K,
Kuwahara K, Imamura H : Multisystem Inflammatory
Syndrome in Children - A New Syndrome Complicated With
Acute Heart Failure Following Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Circ J
25: 948-952, 2021.
20210485
Furuhata S, Okubo T, Imamura H : Investigationof durability against disinfection wash and sterilization of
two-dimensional symbols for individual recognition. Journalof Japanese Association for Operative Medicine 42: 49-57,

2021.
20210486
Yagi T, Nagao K, Tachibana E, Yonemoto N,
Sakamoto K, Ueki Y, Imamura H, Miyamoto T, Takahashi
H, Hanada H, Chiba N, Tani S, Matsumoto N, Okumura
Y : Treatment with Vasopressor Agents for Cardiovascular
Shock Patients with Poor Renal Function; Results from theJapanese Circulation Society Cardiovascular Shock Registry.
Frontiers Med 8: 648824, 2021.

Hematology and Medical Oncology
20210487
Araki T, Tateishi K, Sonehara K, Hirota
S, Komatsu M, Yamamoto M, Kanda S, Kuraishi H,
Hanaoka M, Koizumi T* : Clinical utility of the C-reactive
protein:albumin ratio in non-small cell lung cancer patientstreated with nivolumab. Thorac Cancer 12(5): 603-612,
2021.
20210488
Araki T, Kobayashi T, Kobayashi S, Sonehara
K, Tateishi K, Kanda S, Hanaoka M, Koizumi T : Thymic
epithelial tumor with superior vena cava syndrome
diagnosed by percutaneous endovascular tumor biopsy: A
report of two cases. Respir Investig 59(5): 695-699, 2021.
20210489
Fujimoto A, Anzai T, Fukuda T, Uchida N, Ohta
T, Mori T, Sawa M, Yoshioka S, Miyamoto T, Uchiyama
H, Katayama Y, Matsuoka KI, Shiratori S, Nakazawa H,
Kanda J, Ichinohe T, Atsuta Y, Fujita N, Kondo E, Suzuki
R : Impact of event-free survival status after stem celltransplantation on subsequent survival of patients withlymphoma. Blood Adv 5(5): 1412-1424, 2021.
20210490
Hori A, Ishida F, Nakazawa H, Yamaura
M, Morita S, Uehara T, Honda T, Hidaka H : Serum
sphingomyelin species profile is altered in hematologic
malignancies. Clin Chim Acta 514: 29-33, 2021.
20210491
Imamura H, Kashima Y, Hattori M, Mori K,
Takeshige K, Nakazawa H : Unexplained recurrent shock inperipheral T-cell lymphoma: A case report. Clin Case Rep
9(8): e04612, 2021.
20210492
K a n a z a w a H , S a s a k i N , K o b a y a s h i T,
Fukushima T, Kanda S, Koizumi T*, Iwaya M : Direct
Intraesophageal Growth from Metastatic Mediastinal
Lymphadenopathy in Thymic Carcinoma. Intern Med 60(6):923-926, 2021.
20210493
Kobayashi T, Kanda S*, Fukushima T, Noguchi
T, Sekiguchi N, Koizumi T : Response to lorlatinib on apatient with ALK-rearranged non-small cell lung cancer
harboring 1151Tins mutation with uterine metastasis. Thorac

34

Cancer 12(16): 2275-2278, 2021.
20210494
Koizumi T*, Kanda S, Nihonmatu R, Gomi
D, Sekiguchi N, Noguchi T, Fukushima T, Kobayashi T,
Yamamoto H, Takeda T : Primary mediastinal germ celltumors - A retrospective analysis of >30 years of experiencein a single institution. Thorac Cancer 12(6): 807-813, 2021.
20210495
Kurosawa S, Shimomura Y, Itonaga H, Najima
Y, Kobayashi T, Ozawa Y, Kanda Y, Kako S, Kawakita T,
Matsuoka KI, Maruyama Y, Ota S, Nakazawa H, Imada K,
Kanda J, Fukuda T, Atsuta Y, Aoki J : Fludarabine/busulfan
versus busulfan/cyclophosphamide as myeloablative
conditioning for myelodysplastic syndrome: a propensity
score-matched analysis. .Bone Marrow Transplant 56(12):3008-3015, 2021.
20210496
Matsuoka S, Hasegawa H, Koike S, Koyama
T, Takeda T, Miura K, Eguchi T, Hamanaka K, Kito M,
Takahashi J, Fukusima T, Koizumi T, Shimizu K, Uehara T: Undifferentiated pleomoriphic sarcoma of soft tissue withmultinucleated giant cell with osteogenic phenotypes: A
mimicker of malignant giant cell tumor of soft tissue. J ofHard Tissue Biology 30: 309-316, 2021.
20210497
M a t s u s h i t a H , O z a w a T, S e k i g u c h i N ,Fukushima T, Kobayashi T, Kanda S, Koizumi T* : A
Case of Sinonasal Undifferentiated Carcinoma Sucessfully
Responding to Chemoradiotherapy. Shinshu Med J 69(3):121-126, 2021.
20210498
Nakano Y, Koide N, Koyama Y, Nitta K,
Koizumi T* : Lung adenocarcinoma initially presenting
as Trousseau's syndrome treated successfully withpembrolizumab: A case report. Thorac Cancer 12(4): 557559, 2021.

K, Makino T, Yoshida Y, Hirono Y, Hayashi R, Koizumi
K, Nakazawa Y, Ito K, Motoo Y, Uramoto H, Nakada M,
Nishino Y, Yano S : Multi-institutional survey of cancer
disparities in disabled patients in the region of northwesternJapan. Int J Clin Oncol 26(6): 1009-1014, 2021.
20210502S e k i g u c h i N , K o m a t s u M , I c h i y a m a T,
Kobayashi A, Gomi D, Fukushima T, Kobayashi T,
Noguchi T, Nakazawa H, Asano N, Ishida F, Koizumi T* :CCR4-positive peripheral T-cell lymphoma presenting as
eosinophilic pneumonia and developing from prolonged
pustular psoriasis. J Int Med Res 49(2): 300060521996165,
2021.
20210503
Shimizu Y, Kanda S*, Fukushima T, Kobayashi
T, Kondo R, Koizumi T : Increased carbohydrate antigen
19-9 expression in a thymic neuroendocrine tumor. Thorac
Cancer 12(21): 2949-2952, 2021.
20210504
Sonehara K, Tateishi K, Araki T, Komatsu
M, Yamamoto H, Koizumi T, Hanaoka M : The Role of
Immune-Related Adverse Events in Prognosis and Efficacy
Prediction for Patients with Non-Small Cell Lung Cancer
Treated with Immunotherapy: A Retrospective ClinicalAnalysis. Oncology 99(5): 271-279, 2021.
20210505
Takahashi T, Suzuki R, Yamamoto G, Nakazawa
H, Kurosawa M, Kobayashi T, Okada M, Akasaka T,
Kim SW, Fukuda T, Ichinohe T, Atsuta Y, Suzumiya J :Hematopoietic stem cell transplantation for diffuse large
B-cell lymphoma having 8q24/MYC rearrangement inJapan. Hematol Oncol 39(1): 66-74, 2021.
20210506
Taniguchi S* : In Situ Delivery and Production
System (iDPS) of Anti-Cancer Molecules with GeneEngineered Bifidobacterium. J Pers Med 11 (6): 566, 2021.

20210499
N a k a z a w a H * , Ya m a g u c h i T, S a k a i H ,Maruyama M, Kawakami T, Kawakami F, Nishina S,
Ishikawa M, Kosho T, Ishida F : A novel germline GATA2
frameshift mutation with a premature stop codon in a familywith congenital sensory hearing loss and myelodysplastic
syndrome. Int J Hematol 114(2): 286-291, 2021.

20210507
Tokumaru S, Koizumi T, Sekino Y, Takeuchi
N, Nakata S, Miyagawa Y, Kitazawa M, Muranaka F,
Nakamura S, Koyama M, Yamamoto Y, Ehara T, Hondo N,
Soejima Y : Lymphocyte-to-Monocyte Ratio Is a Predictive
Biomarker of Response to Treatment with Nivolumab for
Gastric Cancer. Oncology 99(10): 632-640, 2021.

20210500
Nishina S, Sakai H, Kawakami T, Kanai S,
Ushiki A, Natori T, Igarashi Y, Mitarai S, Yoshiyama T,
Ishida F, Nakazawa H* : Isolated splenic Mycobacterium
tuberculosis complex infection in an immunocompetent
individual with FDG-PET positive mass. Journal of Infection
and Chemotherapy 27(2): 354-358, 2021.

20210508
Ya m a d a H , F u k u s h i m a T, K o b a y a s h i T,
Kanda S, Koizumi T*, Iwaya M : Successful Response
to Cyclophosphamide, Vincristine, and Dacarbazine
Chemotherapy in a Patient with Metastatic Carotid Body
Paraganglioma. Case Rep Oncol 14(3): 1827-1833, 2021.

20210501
Sato S, Tanimoto A, Yanagimura N, Suzuki C,
Takumi Y, Nishiyama A, Yamashita K, Takeuchi S, Ohtsubo

20210509
Yamaguchi M, Koizumi T, Sugano M : Impact
of short-term storage of plasma samples on quantitationof ultra-low levels of interleukin-6. J Int Med Res 49(11):353000605211056846, 2021.
20210510
Yamashita T, Takamatsu H, Kawamura K,
Sunami K, Hagiwara S, Itagaki M, Takahashi T, Kondo
T, Ikeda T, Watakabe-Inamoto K, Handa H, Imaizumi Y,
Kuroda J, Murakami J, Nakamura Y, Nakazawa H, Ozaki S,
Okura M, Takeuchi M, Nagai H, Hanamura I, Nakao S, Iida
S : A nationwide survey on central nervous system multiple
myeloma in Japan: analysis of prognostic and treatment
factors that impact survival. Br J Haematol 195(2): 217-229,
2021.
20210511
Yanagisawa K, Horiuchi T, Matsuo A, Kuraishi
H, Satomi H, Ito I, Noguchi T, Sekiguchi N, Kanda S,
Koizumi T* : Serial Cancer Development Three Times in a
Patient with Fanconi Anemia. Case Rep Oncol 14(2): 11681174, 2021.
20210512
Yanagisawa R, Nakazawa H, Nishina S, Saito S,
Shigemura T, Tanaka M, Nakazawa Y : Investigation of risk
factors associated with erythrocyte engraftment after ABOincompatible hematopoietic stem cell transplantation. Clin
Transplant 35(6): e14300, 2021.

Child and Adolescent Developmental
Psychiatry20210513
Imai J, Sasayama D*, Kuge R, Honda H,
Washizuka S : Hyperactive/impulsive symptoms andautistic trait in institutionalized children with maltreatment
experience. New Dir Child Adolesc Dev 2021: 29-39, 2021.
20210514
Sasayama D*, Kuge R, Toibana Y, Honda H :Trends in Autism Spectrum Disorder Diagnoses in Japan,
2009 to 2019. JAMA Netw Open 4: e219234, 2021.
20210515
Takemori Y, Sasayama D*, Toida Y, Kotagiri
M, Sugiyama N, Yamaguchi M, Washizuka S, Honda
H : Possible utilization of salivary IFN-γ/IL-4 ratio
as a marker of chronic stress in healthy individuals.
Neuropsychopharmacol Rep 41: 65-72, 2021.
20210516
Sasayama D*, Kudo T, Kaneko W, Kuge R,
Koizumi N, Nomiyama T, Washizuka S, Honda H : Brief
Report: Cumulative Incidence of Autism Spectrum Disorder
Before School Entry in a Thoroughly Screened Population. J
Autism Dev Disord 51: 1400-1405, 2021.
20210517
Saito K, Kuge R*, Nagasawa T, Ohkura T,
Miura M : QT prolongation is over-estimated by Bazett
compared to Friderica in Japanese child and adolescentinpatients. Int Clin Psychopharmacol 36: 268-273, 2021.

20210518
Takahashi F, Honda H : Prevalence of clinical‐
level emotional/behavioral problems in schoolchildren
during the coronavirus disease 2019 pandemic in Japan: Aprospective cohort study. JCPP Advances 1: e12007, 2021.

Brain Disease Research20210519
Kinoshita M, Oyanagi K*, Kondo Y, Ishizawa
K, Ishihara K, Yoshida M, Inoue T, Mitsuyama Y, Yoshida
K, Yamada M, Sekijima Y, Ikeda S : Pathologic basis of thepreferential thinning of the corpus callosum in adult-onset
leukoencephalopathy with axonal spheroids and pigmented
glia (ALSP). eNeurologicalSci 22: 100310, 2021.
20210520
Fukushima K, Nakamura A, Takei Y, Oguchi
K, Itagaki H, Ohara S, Yamada M : Elderly-onset multiple
system atrophy with Lewy body pathology: a case report.
Case Rep Neurol 13: 613-619, 2021.
20210521
Hineno A, Oyanagi K*, Yoshida T, Sakai Y,
Kanno H, Sekijima Y : Spread of vimentin-immunopositive
cells within the plaque-like lesion of the spinal anterior
horn of a patient with post-poliomyelitis syndrome.
Neuropathology 41: 406-411, 2021.
20210522
Matsushima A, Maruyama Y, Mizukami N,
Tetsuya M, Hashimoto M, Yoshida K : Gait training with awearable curara® robot for cerebellar ataxia: a single-arm
study. Biomed Eng Online 20: 90, 2021.
20210523
Waddington-Cruz M, Ando Y, Amass L,
Kiszko J, Chapman D, Sekijima Y : Feasibility of assessing
progression of transthyretin amyloid polyneuropathy using
nerve conduction studies: findings from the Transthyretin
Amyloidosis Outcomes Survey (THAOS). J Peripher Nerv
Syst 26: 160-166, 2021.
20210524
Yanagisawa S, Takahashi Y, Sasaki J, Takasone
K, Yoshie K, Koyama J, Katoh N, Yazaki M, Kuwahara
K, Fujinaga Y, Sekijima Y : Absolute quantitative analysis
of cardiac amyloidosis using SPECT/CT with 99mTcpyrophosphate. Amyloid 28: 213-214, 2021.
20210525
Garcia-Pavia P, Bengel F, Brito D, Damy T,
Duca F, Dorbala S, Nativi-Nicolau J, Obici L, Rapezzi C,
Sekijima Y, Elliott PM : Expert consensus on the monitoringof transthyretin amyloid cardiomyopathy. Eur J Heart Fail
23: 895-905, 2021.

Innovation of Medical and Health Sciences
Research20210526

Watanabe-Asaka T, Hayashi M, Maejima D,

36

Kawai Y, Ohhashi T* : From digestion and absorption to
innate immunity and health care: water and food intake may
contribute to IL-22 in ILC3-dependent mucosal immunity inthe jejunum. J Physiol Sci 71: 31, 2021.
20210527
Ide S, Arai N, Morimitsu N, Momose H,
Hayashi M, Watanabe-Asaka T, Ishida T, Tanaka S, Seto T,
Kawai Y, Kawamata M, Ohhashi T* : Another route of CO2
gas excretion independent of red blood cells in human lungs.
Pflugers Arch 473: 1657-1666, 2021.
20210528
Kajihara R, Amari K, Arai N, Nagashio S,
Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y,
Maejima D, Kawai Y, Ohhashi T* : Water intake releases
serotonin from enterochromaffin cells in rat jejunal villi.
Pflugers Arch 473: 921-936, 2021.
20210529
Hayashi M, Watanabe-Asaka T, Nagashio S,
Kaidoh M, Yokoyama Y, Maejima D, Kajihara R, Amari
K, Arai N, Kawai Y, Ohhashi T* : Water intake accelerates
ATP release from myofibroblast cells in rats: ATP-mediatedpodoplanin-dependent control for physiological function
and immunity. Am J Physiol Gastrointest Liver Physiol 320:
G54-G65, 2021.

Hearing Implant Sciences
2021530
N i s h i o S Y, To n o T, I w a k i T, M o t e k i H ,Suzuki K, Tsushima Y, Kashio A, Akamatsu Y, Sato H,
Yaegashi K, Takeda H, Kumagai F, Nakashima T, Matsuda
Y, Hato N, Dairoku T, Shiroma M, Kawai R, Usami SI*: Development and validation of an iPad-based Japanese
language monosyllable speech perception test (iCI2004
monosyllable). Acta Otolaryngol 141(3): 267-272, 2021.
2021531
Miyake K, Shirai K, Nishiyama N, Kawaguchi
S, Ohta Y, Kawano A, Usami SI, Kitano T, Tsukahara K :Cochlear implantation in a patient with a POU4F3 mutation.
Clin Case Rep 9(1): 298-303, 2021.
2021532
Isaka Y, Nishio SY, Hishinuma E, Hiratsuka M,
Usami SI* : Improvement of a Rapid and Highly Sensitive
Method for the Diagnosis of the Mitochondrial m.1555A>G
Mutation Based on a Single-Stranded Tag Hybridization
Chromatographic Printed-Array Strip. Genet Test Mol
Biomarkers 25(1): 79-83, 2021.
2021533
N a k a s h i m a T, G a n a h a A , Ts u m a g a r i S ,Nakamura T, Yamada Y, Nakamura E, Usami SI*, Tono
T : Is the Conductive Hearing Loss in NOG-Related
Symphalangism Spectrum Disorder Congenital?. ORL J
Otorhinolaryngol Relat Spec 83(3): 196-202, 2021.

2021534
van de Heyning P, Mertens G, Topsakal V, deBrito R, Wimmer W, Caversaccio MD, Dazert S, Volkenstein
S, Zernotti M, Parnes LS, Staecker H, Bruce IA, Rajan G,
Atlas M, Friedland P, Skarzynski PH, Sugarova S, Kuzovkov
V, Hagr A, Mlynski R, Schmutzhard J, Usami SI, Lassaletta
L, Gavilán J, Godey B, Raine CH, Hagen R, Sprinzl GM,
Brown K, Baumgartner WD, Karltorp E : Two-phase survey
on the frequency of use and safety of MRI for hearing
implant recipients. Eur Arch Otorhinolaryngol 278: 42254233, 2021.
2021535
Ishino T, Ogawa Y, Sonoyama T, Taruya
T, Kono T, Hamamoto T, Ueda T, Ishino T, Ogawa Y,
Sonoyama T, Taruya T, Kono T, Hamamoto T, Ueda T,
Takeno S, Moteki H, Nishio SY, Usami SI, Nagano Y,
Yoshimura A, Yoshikawa K, Kato M, Ichimoto M, Watanabe
R : Identification of a Novel Copy Number Variation of
EYA4 Causing Autosomal Dominant Non-Syndromic
Hearing Loss. Otol Neurotol 42(7): e866-e874, 2021.
2021536
Tsukada K, Usami SI* : Vestibular Preservation
After Cochlear Implantation Using the Round Window
Approach. Front Neurol 12: 656592, 2021.
2021537
Matsuda N, Ootsuki K, Kobayashi S, Nemoto
A, Kubo H, Usami SI, Kanai K : A novel case of concurrent
occurrence of demyelinating-polyneuropathy-causing
PMP22 duplication and SOX10 gene mutation producing
severe hypertrophic neuropathy. BMC Neurol 21(1): 243,
2021.
2021538
Yo s h i m u r a H , Ta k a h a s h i M , I w a s a k i S ,Shinagawa J, Takashimizu I, Nagai F, Yotsuyanagi T, Usami
SI* : Vibrant soundbridge implantation prior to auricular
reconstruction with unilateral microtia-atresia. Clin Case
Rep 9(8): e04408, 2021.
2021539
Yoshimura H, Nishio SY, Isaka Y, Kurokawa T,
Usami SI*. The Interactable Hearing Disorder Consortium :A nationwide epidemiologic, clinical, genetic study of Usher
syndrome in Japan. Acta Otolaryngol 141(9): 841-846, 2021.
2021540
Yo s h i m u r a H , N i s h i o S Y, U s a m i S I * :Milestones toward cochlear gene therapy for patientswith hereditary hearing loss. Laryngoscope Investigative
Otolaryngology 6(5): 958-967, 2021.
2021541
Tsukada K, Usami SI* : Vestibular nerve
deficiency and vestibular function in children with unilateral
hearing loss caused by cochlear nerve deficiency. Acta
Otolaryngol 141(9): 835-840, 2021.
2021542

Hiramatsu K, Nishio SY, Kitajiri SI, Kitano T,

37

Moteki H, Usami SI*, On Behalf Of The Deafness Gene
Study Consortium : Prevalence and Clinical Characteristics
of Hearing Loss Caused by MYH14 Variants. Genes(Basel)
12(10): 1623, 2021.

Role of G Protein-Coupled Receptors in Hepatic Stellate
Cells and Approaches to Anti-Fibrotic Treatment of NonAlcoholic Fatty Liver Disease. Front Endocrinol (Lausanne)
12: 773432, 2021.

2021543
Kasuga M, Yoshimura H, Shinagawa J, Nishio
SY, Takumi Y, Usami SI : Frequency and natural courseof congenital cytomegalovirus-associated hearing loss inchildren. Acta Otolaryngol 141(12): 1038-1043, 2021.

Radiology Division

2021544
Miyoshi T, Belyantseva IA, Kitajiri SI,
Miyajima H, Nishio SY, Usami SI, Kim BJ, Choi BY, Omori
K, Shroff H, Friedman TB : Human deafness-associatedvariants alter the dynamics of key molecules in hair cellstereocilia F-actin cores. Hum Genet 141(3-4): 363-382,
2021.
2021545
Usami SI, Isaka Y, Nisho SY, Nakatani T, Itoh T: Phylogeny and biogeography of arctic-alpine butterflies of
the genus Oeneis (Nymphalidae: Satyrinae). Entomological
Science 24: 183-195, 2021.

Clinical Sequence Course
20210546
Hanafusa H, Hidaka Y, Yamaguchi T, Shimojo
H, Tsukahara T, Murase T, Matsuoka D, Chiba N, Shimada
S, Morokawa H, Omori N, Minoura H, Nagano C, Takano
K, Nakamura K, Wakui K, Fukushima Y, Uehara T,
Nakazawa Y, Iijima K, Nozu K, Kosho T* : Heterozygous
missense variant in TRPC6 in a boy with rapidly progressive
infantile nephrotic syndrome associated with diffuse
mesangial sclerosis. Am J Med Genet A 185: 2175-2179,
2021.

International Relations Office20210547
Jia F, Hu X, Kimura T, Tanaka N* : Impact ofDietary Fat on the Progression of Liver Fibrosis: Lessons
from Animal and Cell Studies. Int J Mol Sci 22: 10303,
2021.
20210548
Tanaka N*, Mukaiyama K, Morikawa A,
Kawakami S, Ichise Y, Kimura T, Horiuchi A : Pemafibrate,a novel selective PPARα modulator, attenuates tamoxifeninduced fatty liver disease. Clin J Gastroenterol 14: 846851, 2021.
20210549
Aomura D, Harada M, Yamada Y, Nakajima T,
Hashimoto K, Tanaka N, Kamijo Y : Pemafibrate Protects
against Fatty Acid-Induced Nephropathy by Maintaining
Renal Fatty Acid Metabolism. Metabolites 11: 372, 2021.
20210550

Kimura T, Singh S, Tanaka N*, Umemura T :20210551
Maruyama T*, Hayashi N, Sato Y, Ogura T,
Uehara M, Ogura A, Watanabe H, Kitoh Y, Alzheimer’s
Disease Neuroimaging Initiative : Simultaneous brain
structure segmentation in magnetic resonance images using
deep convolutional neural networks. Radiological Physics
and Technology 14: 358-365, 2021.
20210552
Ya n a g i s a w a S , Ta k a h a s h i Y, S a s a k i J ,Takasone K, Yoshie K, Koyama J, Katoh N, Yazaki
M, Kuwahara K, Fujinaga Y, Sekijima Y : Absolute
quantitative analysis of cardiac amyloidosis using
S P E C T / C T w i t h 99m Tc - p y r o p h o s p h a t e . A m y l o i d
The Journal of Protein Folding Disorders 28: 213-214, 2021.
20210553
Kurozumi M, Takumi Y, Uehara T, Suzuki T,
Ohya A, Shinagawa J, Miyagawa J, Tsukahara Y, Yamada
A, Tsukada K, Suzuki H, Fujinaga Y : Preoperative Arterial
Embolization to Avoid Intraoperative Bleeding during
Endoscopic Sinus Surgery for Organized Hematoma of
the Maxillary Sinus: A Case Series and Literature Review.
Interventional Radiology 6: 102-107, 2021.

Rehabilitation Center
20210554
Oguchi N*, Yamamoto S, Terashima S, Arai
R, Sato M, Ikegami S, Horiuchi H : The modified water
swallowing test score is the best predictor of postoperative
pneumonia following extubation in cardiovascular surgery:A retrospective cohort study. Medicine (Baltimore) 100:e24478, 2021.
20210555
Nishie K, Yamamoto S, Yamaga T, Horita N,
Mori R, Gouda MA, Hanaoka M : Prophylactic cranial
irradiation for extensive-stage small cell lung cancer.
Cochrane Database Syst Rev 2021: CD014559, 2021.
20210556
Yamada Y, Harada M, Hara Y, Iwabuchi R,
Hashimoto K, Yamamoto S, Kamijo Y : Efficacy of plasma
exchange for antineutrophil cytoplasmic antibody-associatedsystemic vasculitis: a systematic review and meta-analysis.
Arthritis Res Ther 23: 28, 2021.
20210557
Nozaki K, Kamiya K, Hamazaki N, Saito H,
Saito K, Ogasahara Y, Maekawa E, Konishi M, Kitai T,
Iwata K, Jujo K, Wada H, Kasai T, Nagamatsu H, Ozawa
T, Izawa K, Yamamoto S, Aizawa N, Makino A, Oka K,

38

Momomura S, Kagiyama N, Matsue Y : Validity and Utilityof the Questionnaire-based FRAIL Scale in Older Patients
With Heart Failure: Findings From the FRAGILE-HF. J Am
Med Dir Assoc 22: 1621-1626.e2, 2021.
20210558
Osawa R, Ikegami S*, Horiuchi H, Tokida R,
Kato H, Takahashi J : Osteoporosis Detection by Physical
Function Tests in Resident Health Exams: A Japanese Cohort
Survey Randomly Sampled from a Basic Resident Registry.
J Clin Med 10: 1896, 2021.
202105459 Tokida R, Uehara M, Nakano M, Suzuki T,
Sakai N, Ikegami S, Takahashi J, Nakamura Y, Kato H :Reference values for bone metabolism in a Japanese cohort
survey randomly sampled from a basic elderly resident
registry. Sci Rep 11: 7822, 2021.
20210560
Ikegami S, Uehara M, Tokida R, Nishimura
H, Sakai N, Horiuchi H, Kato H, Takahashi J : Cervical
Spinal Alignment Change Accompanying Spondylosis
Exposes Harmonization Failure with Total Spinal Balance:
A Japanese Cohort Survey Randomly Sampled from a Basic
Resident Registry. J Clin Med 10: 5737, 2021.
20210561
Sato M, Mutai H, Yamamoto S, Tsukakoshi
D, Takeda S, Oguchi N, Ichimura H, Ikegami S, Wada Y,
Seto T, Horiuchi H : Decreased activities of daily living
at discharge predict mortality and readmission in elderly
patients after cardiac and aortic surgery: A retrospective
cohort study. Medicine (Baltimore) 100: e26819, 2021.
20210562
Yamaga T, Yamamoto S, Sakai Y, Ichiyama
T : Effects of inspiratory muscle training after lungtransplantation in children. BMJ Case Rep 14: e241114,
2021.
20210563
Kawachi S, Yamamoto S, Nishie K, Yamaga
T, Shibuya M, Sakai Y, Fujimoto K : The effectiveness of
supplemental oxygen during exercise training in patientswith chronic obstructive pulmonary disease who show
severe exercise-induced desaturation: a protocol for a metaregression analysis and systematic review. Syst Rev 10: 110,
2021.
20210564
Jujo K, Kagiyama N, Saito K, Kamiya K, Saito
H, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata
K, Wada H, Kasai T, Nagamatsu H, Ozawa T, Izawa K,
Yamamoto S, Aizawa N, Yonezawa R, Oka K, Makizako
H, Momomura S, Matsue Y : Impact of Social Frailty
in Hospitalized Elderly Patients With Heart Failure: A
FRAGILE-HF Registry Subanalysis. J Am Heart Assoc 10:
e019954, 2021.

20210565
Maeda D, Kagiyama N, Jujo K, Saito K,
Kamiya K, Saito H, Ogasahara Y, Maekawa E, Konishi M,
Kitai T, Iwata K, Wada H, Hiki M, Dotare T, Sunayama T,
Kasai T, Nagamatsu H, Ozawa T, Izawa K, Yamamoto S,
Aizawa N, Yonezawa R, Oka K, Momomura S, Matsue Y :Aspartate aminotransferase to alanine aminotransferase ratio
is associated with frailty and mortality in older patients withheart failure. Sci Rep 11: 11957, 2021.
20210566
Saka K, Konishi M, Kagiyama N, Kamiya K,
Saito H, Saito K, Ogasahara Y, Maekawa E, Misumi T, Kitai
T, Iwata K, Jujo K, Wada H, Kasai T, Nagamatsu H, Ozawa
T, Izawa K, Yamamoto S, Aizawa N, Makino A, Oka K,
Kimura K, Tamura K, Momomura S, Matsue Y : Impact ofphysical performance on exercise capacity in older patientswith heart failure with reduced and preserved ejection
fraction. Exp Gerontol 156: 111626, 2021.
20210567
Okamura M, Taito S, Yamamoto S* : Effect ofTraining on Peak Oxygen Consumption in Patients With
Heart Failure With Preserved Ejection Fraction. JAMA 326:
771, 2021.
20210568
C h o n g N J , Ya m a m o t o S , Wo n g R C C :Treatment for hyperkalaemia in heart failure: a network
meta-analysis (Protocol). Cochrane Database Syst Rev
2021: CD014770, 2021.

Center for Medical Genetics
20210569
Hanafusa H, Hidaka Y, Yamaguchi T, Shimojo
H, Tsukahara T, Murase T, Matsuoka D, Chiba N, Shimada
S, Morokawa H, Omori N, Minoura H, Nagano C, Takano
K, Nakamura K, Wakui K, Fukushima Y, Uehara T,
Nakazawa Y, Iijima K, Nozu K, Kosho T* : Heterozygous
missense variant in TRPC6 in a boy with rapidly progressive
infantile nephrotic syndrome associated with diffuse
mesangial sclerosis. Am J Med Genet A 185: 2175-2179,
2021.
20210570
Ogawa A, Watanabe T, Natsume T, Okura E,
Saito S, Kato S, Nakayama Y, Furukawa S, Yamaguchi T,
Kosho T, Uehara T, Kobayashi N, Agematsu K, Nakazawa
Y, Shigemura T : Early-onset Inflammatory Bowel Disease
Caused by Mutations in the X-linked Gene IL2RG . J
Investig Allergol Clin Immunol 31: 69-71, 2021.
20210571
Aono Y, Hamatani Y, Katoh N, Nakagawa M,
Nakamura K, Yazaki M, Kametani F, Iguchi M, Murakami
I, Ogawa H, Abe M, Akao M, Sekijima Y : Late-onset
Hereditary ATTR Amyloidosis with a Novel pP63S (P43S)
Transthyretin Variant . Intern Med (in press) 60: 557-561,
2021.

39

20210572
Uekawa K, Kaku Y, Amadatsu T, Matsuzaki
H, Ohmori Y, Kawano T, Hirata S, Yamaguchi T, Kosho T,
Mukasa A : Intracranial and extracranial multiple arterial
dissecting aneurysms in rheumatoid arthritis: A case report .
Interv Neuroradiol 27: 212-218, 2021.
20210573
Iwayama H, Tanaka T, Aoyama K, Moroto
M, Adachi S, Fujisawa Y, Matsuura H, Takano K, Mizuno
H, Okumura A : Regional Difference in Myelination in
Monocarboxylate Transporter 8 Deficiency: Case Reports
and Literature Review of Cases in Japan . Front Neurol 12:657820, 2021.
20210574
Nakazawa H, Yamaguchi T, Sakai H, Maruyama
M, Kawakami T, Kawakami F, Nishina S, Ishikawa M,
Kosho T, Ishida F : A novel germline GATA2 frameshift
mutation with a premature stop codon in a family withcongenital sensory hearing loss and myelodysplastic
syndrome . Int J Hematol 114: 286-291, 2021.
20210575
Iwayama H, Kakita H, Iwasa M, Adachi S,
Takano K, Kikuchi M, Fujisawa Y, Osaka H, Yamada Y,
Okumura A, Hirani K, Weiss RE, Refetoff S : Measurementof Reverse Triiodothyronine Level and the Triiodothyronine
to Reverse Triiodothyronine Ratio in Dried Blood Spot
Samples at Birth May Facilitate Early Detection of
Monocarboxylate Transporter 8 Deficiency. Thyroid 31:
1316-1321, 2021.
20210576
Hara-Isono K, Matsubara K, Hamada
R, Shimada S, Yamaguchi T, Wakui K, Miyazaki O,
Muroya K, Kurosawa K, Fukami M, Ogata T, Kosho T,
Kagami M : A patient with Silver-Russell syndrome withmultilocus imprinting disturbance, and Schimke immunoosseous dysplasia unmasked by uniparental isodisomy ofchromosome 2 . J Hum Genet 66: 1121-1126, 2021.
20210577
Yamamoto H, Itamoto C, Yamaguchi T, Koshyo
T : Severe Hypoxemia Caused by High-Output Heart Failure
and Pulmonary Arteriovenous Malformations in Hereditary
Hemorrhagic Telangiectasia. JACC Case Rep 3: 1863-1868,
2021.

Shinshu Cancer Center
20210578
Yamamoto K, Mamiya K*, Furukawa H : A
Rare Complication of Retrograde Ejaculation after Lumbar
Sympathetic Block and its Spontaneous Recovery: A Case
Report. Shinshu Med J 69(1): 53-56, 2021.

Department of Pharmacy
20210579

Shiozawa A, Yamaori S*, Kamijo S, Ohmori S: Effects of acid and lactone forms of statins on S-warfarin
7-hydroxylation catalyzed by human liver microsomes andrecombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3).
Drug Metab Pharmacokinet 36: 100364, 2021.
20210580
Takachi T, Watanabe T, Miyamura T, Moriya
Saito A, Deguchi T, Hori T, Yamada T, Ohmori S, Haba
M, Aoki Y, Ishimaru S, Sasaki S, Ohshima J, Iguchi A,
Takahashi Y, Hyakuna N, Manabe A, Horibe K, Ishii E, Koh
K, Tomizawa D : Hematopoietic stem cell transplantation
for infants with high-risk KMT2A gene-rearranged acutelymphoblastic leukemia. Blood Adv 5: 3891-3899, 2021.

Center for Clinical Research20210581
Sano K, Asahina M, Uehara T, Araki N,
Yamanaka Y, Matsumoto K, Okuyama R : Clear cell injury
associated with reduced expression of carbonic anhydrase
Ⅱ in eccrine glands consistently occurs in patients withacquired idiopathic generalized anhidrosis. J Dermatol 48:
439-446, 2021.

Medical Safety Management Room20210582
Shimizu I, Matsuyama Y, Duvivier R, van der
Vleuten C : Contextual attributes to promote positive social
interdependence in problem-based learning: a focus groupstudy. BMC Med Educ 21: 1-9, 2021.

Division of Animal Research20210583
Ono-Ohmachi A, Ishida Y, Morita Y, Kato K,
Yamanaka H, Masuyama R : Bone mass protective potential
mediated by bovine milk basic protein requires normal
calcium homeostasis in mice. Nutrition 91-92: 111409, 2021.
20210584
Badawi M, Mori T, Kurihara T, Yoshizawa
T, Nohara K, Kouyama-Suzuki E, Yanagawa T, Shirai Y,
Tabuchi K : Risperidone mitigates enhanced excitatoryneuronal function and repetitive behavior caused by an
ASD-associated mutation of SIK1. Front Mol Neurosci 14:
706494, 2021.
20210585
Mehta A, Shirai Y, Kouyama-Suzuki E, Zhou
M, Yoshizawa T, Yanagawa T, Mori T, Tabuchi K : IQSEC2
deficiency results in abnormal social behaviors relevant to
autism by affecting functions of neural circuits in the medial
prefrontal cortex. Cells 10(10): 2724, 2021.
20210586
Nitahara-Kasahara Y, Mizumoto S, Inoue
YU, Saka S, Posadas-Herrera G, Nakamura-Takahashi A,
Takahashi Y, Hashimoto A, Konishi K, Miyata S, Masuda C,
Matsumoto E, Maruoka Y, Yoshizawa T, Tanase T, Inoue T,40

Yamada S, Nomura Y, Takeda S, Watanabe A, Kosho T, Okada
T : A new mouse model of Ehlers-Danlos syndrome generatedusing CRISPR/Cas9-mediated genomic editing. Dis Model
Mech 14(2): dmm048963, 2021.

41

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遺
No．50
2021

43

Center for Medical Genetics
Matsuoka D, Noda S, Kamiya M, Hidaka Y,
Shimojo H, Yamada Y, Miyamoto T, Nozu K, Iijima K,
Tsukaguchi H : Immune-complex glomerulonephritis with amembranoproliferative pattern in Frasier syndrome: a casereport and review of the literature . BMC Nephrol 21: 362,
2020.

20200544

信大
州学
大医
学学
医部
学業
部績
業録
績編
録集要
集項
要（
項抜粋）
信州
（令和 4 年11月24日改正）

１．収録対象 ２．収録対象
信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で認めた施設等に所属する者（当該年に在籍した者全員）認めた施設等に所属する者（当該年に在籍した者全員）
２．収録内容 ３．収録内容
収録対象は、本文が欧文で執筆された研究業績とし、次の３項目に分ける。
研究業績を次の２項目に分ける。
１）論文
１）論文
原著、綜説、展望、症例報告、速報、予報で、査読のある学術雑誌に発表のもの。
原著、綜説、展望、症例報告、速報、予報で学術雑誌に発表のもの。
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をも
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をもち、ち、別刷が発行されているもの）
別刷が発行されているもの）
２）著書
２）著書
単行書、分担執筆。
単行書、分担執筆。
３）その他
治療指針、トピックス、事典等、専門的知見にもとづき執筆された、論文形式の
ただし、以下のものは除外する。
記事（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表に関するもの及び１頁ものの速報は抄録とみなす）
ただし、以下のものは除外する。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表（ハ）業務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）
に関するもの及び１頁ものの速報は抄録とみなす）（ニ）座談会記事。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（ホ）学会記。
（ハ）業務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）（ヘ）質疑応答（and ）、治療指針、問題集の解説、トピックス、話題、グラビア、（ニ）座談会記事。
事典等に類するもの。
（ホ）学会記。
（ト）新聞記事、教育に関する記事、人物紹介、書評、随筆など学術性が認められ（ヘ）論文形式をとらない質疑応答（Q and A）、問題集の解説、話題、グラビア等ないもの。
に類するもの。
（チ）著者表示が団体名で個人の著者性が認められないもの。
（ト）新聞・週刊誌記事、教育に関する記事、人物紹介、書評、随筆など学術性が（リ）学術雑誌とは認められないものに発表したもの。
認められないもの。
（ ） 本及び 論文。
（チ）著者表示が団体名で個人の著者性が認められないもの。
４．収録期間
毎年１月～12月

あ と が きあ と が き信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録第50号をお届けします。
第１号の業績録には、1972年に発表された英語論文55本（全論文339本）が掲載されておりました。それから50年の歳月が流れ、2021年に信州大学医学部から発表された英語論文数は586
信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録第 38 号をお届けします。
本と、10倍以上になりました。診療や教育で忙しい中、論文を発表された先生方の熱意、努力に敬意を表します。今回、区切りとなる第50号の業績録を担当させて頂き、大変光栄です。出
版委員会の同志であります堀内哲吉教授、福山哲広先生、北沢将人先生には、業績録に掲載可
本業績録は１年間、各講座や部門等でなされた４つの活動（研究、教育、診療、 会）
能な論文を厳格に審査して頂きました。そして医学部図書館の後閑壮登様、滝口智子様には、のうち、研究活動の成果として公表された論文を中 にまとめたものです。
、
評
事務作業で大変お世話になりました。皆様に厚く御礼申し上げます。
研究は大学の使命であり、その成果を論文として発表することは大学人の責務です。研究を、学内外への報告において、本業績録の果たすは 要と思われます。このようなから、綿密に計画してから、新たなエビデンスを得て、それを論理的思考に基づいて論文にまとめ、この１年間の研究活動を り り、今後の方 性等を考える 機にしていただけたら幸いに学術雑誌に発表するまでに、多大な労力と時間を要します。信州大学医学部から発表された英ます。
語論文数は2019年
445本、2020年 543本、2021年 586本と、年々増加しています。業績録を詳細に見ますと、誰がどのような研究を行っているか、明確に理解できます。是非本号を注意深くご覧頂き、我々の研究活動の「今と未来」を考える機会にして頂きたいです。
今年 の英文論文総数は 年 よりし、90 年 以 で最も ない 386 という 果となり現在の研究の特徴の一つとして、膨大な臨床データを用いた多施設共同研究の普及が挙げらました。しかしながら、単なる総数のみの評 がしも 切であるとは言え 、今年 の業れます。データを他施設に提供することで、研究協力者として論文に名前を連ねることができますが、そのような研究は信州大学オリジナルとは言えません。そこで本号から、コレスポン
績の中には めて質の い研究成果も なくありません。今日、 業生の大学 れや医学科入デンスオーサーにアスタリスクをつけ、論文の責任者を明示することにしました。各教室でア
学 員数増加等により、診療や教育活動等の業務は増加の一 にあります。このような現スタリスクのついた論文が毎年増えていく、そして将来の信州大学医学部を担う若手研究者・医師にアスタリスクがつくことを期待しています。
ではありますが、研究活動は大学が大学であるための大きな責務であり、外部評 基 のまた、他大学の業績録を見ますと、原著・症例報告・総説と分けて表示しているケースが多要項目であることは言うまでもありません。今後、各講座・部門等でのさらなる研究の発展をいです。研究成果は原著として発表されますので、コレスポンデンスを取っている原著論文数
祈念 します。
が、その大学の研究活動をより正確に表しているとも言えます。今後、我々の業績録でも、そのような区分けを導入したいと考えております。
さらに、各教室が現在注力している研究テーマを把握できるように、2021年から教室代表論
最後に、本業績録の 集にあたりご 力頂きました先生方、図書館 員の方々に厚く御礼申文リストを作成し、公開しています（https://www.shinshu-u.ac.jp/faculty/medicine/international/）。
し上げます。
業績録と合わせて、ご一読頂けますと幸いです。
最後に、この業績録が信州大学医学部の研究活動のさらなる活性化につながることを祈念し、あとがきとさせて頂きます。関係者の皆様、本当にありがとうございました。
英樹
田中直樹
出 版 委 員 長：英樹
出出 版版委 委員 員：
長：田中直樹山、 田文 、
知
出 版 委 員：堀内哲吉、福山哲広、北沢将人
医医学部図書館
学 部 図 書 査：
館：後閑壮登、滝口智子

第第 50 号
号
年11月
令和 25 年
月221日印刷
日印刷
年11月
令和 25 年
月221日発行日発行

発行
印刷

信州大学医学部
1

印刷

21

1

N 1881ー4980

No.50 (2021)

信 州 大 学 医 学 部 医 学 科・大 学 院 医 学 系 研 究 科・医 学 部 附 属 病 院 業 績 録

信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録

第五〇号（二〇二一）

二〇二二2022