1881ー4 80

No.44 (2015)

信 州 大 学 医 学 部 医 学 科・大 学 院 医 学 系 研 究 科・医 学 部 附 属 病 院 業 績 録

信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録

第四四号（二〇一五 ）

二〇一六

2016

信大
州学
大医
学学
医部
学業
部績
業録
績編
録集
編要
集項
要（
項抜粋）
信州
（平成27年２月28日改正）

１．収録対象 １．収録対象
 信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で認めた施設等に所属する者（当該年に在籍した者全員）認めた施設等に所属する者（当該年度に在籍した者全員）
２．収録内容 ２．収録内容
研究業績を次の３項目に分ける。
研究業績を次の２項目に分ける。
１）論文
１）論文
原著、綜説、展望、症例報告、速報、予報で、査読のある学術雑誌に発表のもの。
原著、綜説、展望、症例報告、速報、予報で学術雑誌に発表のもの。
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をも
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をもち、ち、別刷が発行されているもの）
別刷が発行されているもの）
２）著書
２）著書
単行書、分担執筆。
単行書、分担執筆。
３）その他
治療指針、トピックス、事典等、専門的知見にもとづき執筆された、論文形式の
ただし、以下のものは除外する。
記事（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表に関するもの及び１頁ものの速報は抄録とみなす）
ただし、以下のものは除外する。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表（ハ）業務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）
に関するもの及び１頁ものの速報は抄録とみなす）（ニ）座談会記事。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（ホ）学会記。
（ハ）業and
務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）（ヘ）質疑応答（）、治療指針、問題集の解説、トピックス、話題、グラビア、
（ニ）
座
談会記事。
事典等に類するもの。
（ホ）学会記。
（ト）新聞記事、教育に関する記事、人物紹介、書評、随筆など学術性が認められ（ヘ）論文形式をとらない質疑応答（Q and A）、問題集の解説、話題、グラビア等ないもの。
に類するもの。
（チ）著者表示が団体名で個人の著者性が認められないもの。
（ト）新聞・週刊誌記事、教育に関する記事、人物紹介、書評、随筆など学術性が（ ）学術雑誌とは認められないものに発表したもの。
認められないもの。
（ ） 本及び 論文。
（チ）著者表示が団体名で個人の著者性が認められないもの。
３．収録期間
毎年１月～12月

あ

と

が

き

信州大学医学部医学科
・大学院医学系研究科・医学部附属病院業績録第44号をお届けします。
信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録第8 号をお届けします。
本業績録は過去１年間、各教室や部門などでなされた４つの活動（研究活動、教育活動、診本業績録は過去１年間、各講座や部門等でなされた４つの活動（研究、教育、診療、社会貢献）
療活動、社会貢献）のうち、研究活動の成果として公表された論文を中心にまとめたものです。
のうち、研究活動の成果として公表された論文を中心にまとめたものです。自己点検、自己評
自己点検、自己評価、学内・学外への報告において、本業績録の役割は重要と思われます。この１年の研究活動を振り返り、今後の方向性を考える契機にしていただければ幸いです。
価、学内外への報告において、本業績録の果たす役割は重要と思われます。このような 点から、この１年間の研究活動を振り返り、今後の方向性等を考える契機にしていただけたら幸いに運営費交付金の毎年一定比率削減と重点配分による、中堅大学での研究力の落ち込みが、日じます。
本の論文発表件数の減少、研究競争力の低下につながっていることが指摘されるようになりました（いわゆる豊田レポート）。要するに、研究の裾野を狭めることで、全国に散らばる潜在能力が発揮されにくくなり、コンピテントな研究者の実質的な層が薄くなってしまったという
今年度の 文論文 数は 年度より 減し、 0 年度以 で最も少ない 8 という 果となりことです。そのため、毎年のように日本の受賞者が出るようになったノーベル賞も、最近は喜ました。しかしながら、単なる 数のみの評価がしもであるとは え 、今年度の業
ばれるだけでなく、現場を知る研究者の将来への危惧のコメントがむしろ目立つようになりました。
績の中には めて質の い研究成果も少なくありま。今日、 業生の大学 れや医学科
学定員数増加等により、診療や教育活動等の業務は増加の一 にあります。このような現さて、そのような中堅大学に特に厳しい研究環境の中で、このたびの業績録を見ますと、こではありますが、研究活動は大学が大学であるための大きな 務であり、外部評価 準の重の数年間、一定水準を維持してきていることがわかります。研究者数の減少の中でこのように要項目であることは うまでもありま。今後、各講座・部門等でのさらなる研究の発展を水準が保たれている根底には、現場の先生方それぞれの血のにじむような努力があることが、痛いほどわかります。
祈します。
折しも、2017年度からの科学技術関連予算の十数%の増加が、文科省から打ち出されています。科学の裾野を広げる方向に転換することを祈るばかりです。
最後に、本業績録の編集にあたりご尽力頂きました先生方、図書館職員の方々に厚く御礼申
最後に、本業績録の編集にあたりご尽力頂きました先生方、図書館職員の方々に厚く御礼申し上げます。
し上げます。

沢村 達也
村
出出 版
版委
委員
員 長：沢村達也
長： 村
出出 版
委 員：鷲塚伸介、瀬戸達一郎、伊東清志
版 委 員：平、 田文 、
知
医学部図書館主査：岩井雅史
医学部図書館主査：

第第 44 号
号
平成
平成 23
29 年１月年１月230日印刷
日印刷
平成
平成 23
29 年１月年１月230日発行
日発行

発行
印刷

3

印刷

2

a

44
（ 2 0 1

201

）

3

32

3

0

b

1

I. Scientific Achievements of Shinshu University School of Medicine,
Shinshu University Graduate School of Medicine,and Shinshu University Hospital

Histology and Embryology ..........................................3

Obstetrics and Gynecology ........................................22

Anatomy.......................................................................3

Anesthesiology and Resuscitology ............................22

Physiology....................................................................3

Plastic and Reconstructive Surgery............................23

Molecular & Cellular Physiology ................................3

Emergency and Critical Care Medicine .....................23

Molecular Pharmacology .............................................4

Comprehensive Cancer Therapy ................................23

Pathology .....................................................................4

Brain Disease Research..............................................23

Pathobiology ................................................................4

Lower Urinary Tract Medicine ..................................24

Molecular and Cellular Immunology ...........................5

Home-Care Promotion ...............................................24

Medical Genetics .........................................................5

Innovation of Medical and Health Sciences Research..25

Preventive Medicine and Public Health .......................5

Center for Medical Education and Clinical Training .25

Legal Medicine ............................................................5

Aging Biology............................................................25

Internal Medicine 1 ......................................................6

Neuroplasticity ...........................................................25

Internal Medicine 2 ......................................................6

Molecular Oncology ..................................................26

Internal Medicine 3 ......................................................7

Molecular Pathology ..................................................26

Internal Medicine 4 ......................................................9Metabolic Regulation .................................................26

Internal Medicine 5 ......................................................9

Cardiovascular Research ............................................27

Psychiatry...................................................................11

Sports Medical Sciences ............................................27

Pediatrics ....................................................................12

Health Education and Psychology .............................27

Dermatology ..............................................................13

Laboratory Medicine ..................................................28

Radiology ...................................................................15

Blood Transfusion Center ..........................................30

Surgery 1 ....................................................................15

Endoscopic Examination Center ................................30

Surgery 2 ....................................................................16

Medical Informatics ..................................................31

Orthopaedic Surgery ..................................................17

Clinical and Molecular Genetics ................................31

Neurosurgery..............................................................19

Advance Center for Cellular Therapy ........................31

Dentistry & Oral Surgery ...........................................20

Department of Pharmacy ...........................................32

Urology ......................................................................20

Clinical Resident Training Center..............................32

Ophthalmology ..........................................................20

Laboratory of Animal Research .................................32

Otorhinolaryngology ..................................................21

2

3

Histology and Embryology
20150001
Seguchi S, Yue F, Asanuma K, Sasaki K :Experimental splenosis in the liver and lung spread throughthe vasculature. Cell Tissue Res 360: 287-296, 2015.
20150002
Takahashi Y, Tomotsune D, Takizawa S, Yue F,
Nagai M, Yokoyama T, Hirashima K, Sasaki K : New model
for cardiomyocyte sheet transplantation using a virus-cellfusion technique. World J Stem Cells 7(5): 883-893, 2015.

Anatomy20150003
Kawagishi K, Ando M, Yokouchi K, Sumitomo
N, Karasawa M, Fukushima N, Moriizumi T : Stereologicalestimation of olfactory receptor neurons in rats. Chem Senses
40: 89-95, 2015.
20150004
Fukushima N, Yokouchi K, Kawagishi K,
Karasawa M, Kuroiwa M, Moriizumi T : Two specific tongue
regions receive bilateral hypoglossal innervation: a study inneonatal rat pups. Arch Oral Biol 60: 432-438, 2015.
20150005
Kakegawa A, Yokouchi K, Itsubo T, Kawagishi
K, Karasawa M, Moriizumi T, Fukushima N : Correlation
between motor function and axonal morphology in neonatally
sciatic nerve-injured rats. Anat Sci Int 90: 97-103, 2015.
20150006
Karasawa M, Yokouchi K, Kakegawa A,
Kawagishi K, Moriizumi T, Fukushima N : Effect of gradednerve pressure injuries on motor function. J Neurosurg 122:
1438-1443, 2015.
20150007
Matsuki H, Shibano J, Kobayashi M, Nakatsuchi
Y, Moriizumi T, Kato H : Elastic modulus of the femoral
trochanteric region measured by scanning acoustic microscopy
in elderly women. J Med Ultrason 42: 303-313, 2015.

Physiology
20150008
Morton JS, Quon A, Cheung PY, Sawamura
T, Davidge ST : Effect of sodium tanshinone IIA sulfonate
treatment in a rat model of preeclampsia. Am J Physiol Regul
Integr Comp Physiol 308: R163-R172, 2015.
20150009
Nakayachi M, Ito J, Hayashida C, Ohyama
Y, Kakino A, Okayasu M, Sato T, Ogasawara T, Kaneda T,
Suda N, Sawamura T, Hakeda Y : Lectin-like oxidized lowdensity lipoprotein receptor-1 abrogation causes resistance toinflammatory bone destruction in mice, despite promoting
osteoclastogenesis in the steady state. Bone 75: 170-182,
2015.

20150010
Tomita T, Ieguchi K, Sawamura T, Maru Y :Human serum amyloid A3 (SAA3) protein, expressed as afusion protein with SAA2, binds the oxidized low density
lipoprotein receptor. PLoS One 10: e0118835, 2015.
20150011
Uetake Y, Ikeda H, Irie R, Tejima K, Matsui H,
Ogura S, Wang H, Mu S, Hirohama D,,o K, Sawamura T,
Yatomi Y, Fujita T, Shimosawa T : High-salt in addition tohigh-fat diet may enhance inflammation and fibrosis in liver
steatosis induced by oxidative stress and dyslipidemia in mice.
Lipids Health Dis 14: 6, 2015.
20150012
Yamamoto K, Kakino A, Takeshita H, Hayashi N,
Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi
Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M,
Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi
M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M,
Kurtz TW, Sawamura T, Rakugi H : Oxidized LDL (oxLDL)
activates the angiotensin II type 1 receptor by binding to thelectin-like oxLDL receptor. FASEB J 29: 3342-3356, 2015.
20150013
Sugiyama D, Higashiyama A, Wakabayashi I,
Kubota Y, Adachi Y, Hayashibe A, Kawamura K, Kuwabara
K, Nishimura K, Kadota A, Nishida Y, Hirata T, Imano H,
Miyamatsu N, Miyamoto Y, Sawamura T, Okamura T :The relationship between lectin-like oxidized low-density
lipoprotein receptor-1 ligands containing apolipoprotein B
and the cardio-ankle vascular index in healthy community
inhabitants: The KOBE study. J Atheroscler Thromb 22: 499508, 2015.
20150014
Lin FY, Tsao NW, Shih CM, Lin YW, Yeh JS,
Chen JW, Nakagami H, Morishita R, Sawamura T, Huang CY: The biphasic effects of oxidized-low density lipoprotein on
the vasculogenic function of endothelial progenitor cells. PLoS
One 10: e0123971, 2015.
20150015
Ding Z, Liu S, Wang X, Deng X, Fan Y,
Shahanawaz J, Shmookler Reis RJ, Varughese KI, Sawamura
T, Mehta JL : Cross-talk between LOX-1 and PCSK9 in
vascular tissues. Cardiovasc Res 107: 556-567, 2015.
20150016
Chang KC, Lee AS, Chen WY, Lin YN, Hsu
JF, Chan HC, Chang CM, Chang SS, Pan CC, Sawamura T,
Chang CT, Su MJ, Chen CH : Increased LDL electronegativity
in chronic kidney disease disrupts calcium homeostasis
resulting in cardiac dysfunction. J Mol Cell Cardiol 84: 36-44,
2015.

Molecular & Cellular Physiology
20150017
Anderson GR, Aoto J, Tabuchi K, Földy C, Covy
J, Yee AX, Wu D, Lee SJ, Chen L, Malenka RC, Südhof TC :

4

β-Neurexins Control Neural Circuits by Regulating Synaptic
Endocannabinoid Signaling. Cell 162(3): 593-606, 2015.
20150018
Aoto J, Földy C, Ilcus SM, Tabuchi K, Südhof
TC : Distinct circuit-dependent functions of presynaptic
neurexin-3 at GABAergic and glutamatergic synapses. Nat
Neurosci 18(7): 997-1007, 2015.
20150019
Ko JS, Pramanik G, Um JW, Shim JS, Lee D,
Kim KH, Chung GY, Condomitti G, Kim HM, Kim H, de Wit
J, Park KS, Tabuchi K, Ko J : PTPσ functions as a presynaptic
receptor for the glypican-4/LRRTM4 complex and is essential
for excitatory synaptic transmission. Proc Natl Acad Sci U S A
112(6): 1874-1879, 2015.
20150020
Nagaoka T, Tabuchi K, Kishi M : PDZ interactionof Vangl2 links PSD-95 and Prickle2 but plays only a limited
role in the synaptic localisation of Vangl2. Sci Rep 5: 12916,
2015.
20150021
Yamagata A, Yoshida T, Sato Y, Goto-Ito S,
Uemura T, Maeda A, Shiroshima T, Iwasawa-Okamoto S, Mori
H, Mishina M, Fukai S : Mechanisms of splicing-dependenttrans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for
synaptic differentiation. Nat Commun 6: 6926, 2015.
20150022
Yamagata A, Sato Y, Goto-Ito S, Uemura T,
Maeda A, Shiroshima T, Yoshida T, Fukai S : Structure of
Slitrk2-PTPδ complex reveals mechanisms for splicingdependent trans-synaptic adhesion. Sci Rep 5: 9686, 2015.

Molecular Pharmacology
20150023
Gautam M, Fujita D, Kimura K, Ichikawa H,
Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M,
Ikeda U, Shiba Y : Transplantation of adipose tissue-derived
stem cells improves cardiac contractile function and electricalstability in a rat myocardial infarction model. J Mol Cell
Cardiol 81: 139-149, 2015.

Tateiwa N, Iwaya Y, Momose M, Uehara T : Principal cells ingastric neoplasia of fundic gland (chief cell predominant) typeshow characteristics of immature chief cells. Pathol Int 65:
202-204, 2015.
20150027
Kobayashi M, Uehara T, Horikawa M, Kobayashi
T, Sakai H, Honda T : Flower-like/clover leaf lymphocytes
appear in various diseases: cerebrospinal fluid cytology casewith review of the literature. Diagn Cytopathol 43: 88-90,2015.
20150028
Shigemura T, Nakazawa Y, Amano Y, Sudo
A, Watanabe M,Kobayashi M, Kobayashi N, Koike K,
Agematsu K, Nishimura K : Subcutaneous abscess due tothe basidiomycete Phellinus mori in a patient with chronic
granulomatous disease. Infection 43: 371-375, 2015.

Pathobiology
20150029
Migita K, Izumi Y, Fu jikawa K, Agematsu
K, Masumoto J, Jiuchi Y, Kozuru H, Nonaka F, Shimizu
T, Nakamura T, Iwanaga N, Furukawa H, Yasunami M,
Kawakami A, Eguchi K : Dysregulated mature IL-1ß
production in familial Mediterranean fever. Rheumatology 54:
660-665, 2015.
20150030
Motobayashi M, Inaba Y, Fukuyama T, Kurata
T, Niimi T, Saito S, Shiba N, Nishimura T, Shigemura
T, Nakazawa Y, Kobayashi N, Sakashita K, Agematsu
K, Ichikawa M, Koike K : Successful treatment for West
Syndrome With severe combined immunodeficiency. Brain
Dev 37(1): 140-144, 2015.
20150031
Kobayashi N, Takezaki S, Kobayashi I, Iwata N,
Mori M, Nagai K, Nakano N,.Miyoshi M, Kinjo N, Murata
T, Masunaga K, Umebayashi H, Imagawa T, Agematsu K,
Sato S, Kuwana M, Yamada M, Takei S, Yokota S, Koike
K, Ariga T : Clinical and laboratory features of fatal rapidly
progressive interstitial lung disease associated with juvenile
dermatomyositis. Rheumatology 54: 784-791, 2015.

Pathology
20150024
Aoki T, Tensho K, Shimodaira H, Akaoka Y,
Takanashi S, Shimojo H, Saito N, Kato H : Intrameniscal
Gouty Tophi in the Knee, A Case Report. J Bone Joint Surg
Case Connect 5: e74, 2015.
20150025
Makino M, Kawaguchi K, Shimojo H, Nakamura
H, Nagasawa M, Kodama R : Extensive lanthanum depositionin the gastric mucosa: the first histopathological report. Pathol
Int 65: 33-37, 2015.
20150026

Ota H, Yamaguchi D, Iwaya M, Kobayashi M,

20150032
Ka wa m u ra S,Agema tsu K,Ka wa m u ra
D,Kawamura G,Suzuki K,Minami M : A Case Report of
Familial Mediterranean Fever Diagnosed Following the Total
Knee Arthroplasty. HSS J 11: 278-280, 2015.
20150033
Miyagi T, Itonaga H, Aosai F, Taguchi J, Norose
K, Mochizuki K, Fujii H, Furumoto A, Ohama M, Karimata
K, Yamanoha A, Taniguchi H, Sato S, Taira N, Moriuchi Y,
Fukushima T, Masuzaki H, Miyazaki Y : Successful treatmentof toxoplasmic encephalitis early diagnosed by a polymerase
chain reaction after allogeneic hematopoietic stem celltransplantation: two cases reports and review of the literature.

5Transpl Infect Dis 17: 593-598, 2015.

Preventive Medicine and Public Health20150034
Abdel-Hafeez EH, Mohamed RM, Belal US,
Atiya AM, Takamoto M, Aosai F : Human wound myiasis
caused by Phormia regina and Sarcophaga haemorrhoidalisin Minia Governorate, Egypt. Parasitol Res 114: 3703-3709,
2015.

Molecular and Cellular Immunology
20150035
Sumiya E, Negishi-Koga T, Nagai Y, Suematsu A,
Suda T, Shinohara M, Sato K, Sanjo H, Akira S, Takayanagi H: Phosphoproteomic analysis of kinase-deficient mice reveals
multiple TAK1 targets in osteoclast differentiation. Biochem
Biophys Res Commun 463: 1284-1290, 2015.
20150036
Sa n jo H, Tok u ma r u S, Akira S, Ta ki S :Conditional Deletion of TAK1 in T Cells Reveals a Pivotal
Role of TCRαβ+ Intraepithelial Lymphocytes in Preventing
Lymphopenia-Associated Colitis. PLoS One 10: e0128761,
2015.

Medical Genetics
20150037
Nishi E, Miz u no S, Na n jo Y, Niihor i T,
Fukushima Y, Matsubara Y, Aoki Y, Kosho T : A novel
heterozygous MAP2K1 mutation in a patient with Noonan
syndrome with multiple lentigines. Am J Med Genet A 167A:
407-411, 2015.
20150038
Higurashi N, Takahashi Y, Kashimada A,
Sugawara Y, Sakuma H, Tomonoh Y, Inoue T, Hoshina M,
Satomi R, Ohfu M, Itomi K, Takano K, Kirino T, Hirose S :Immediate suppression of seizure clusters by corticosteroids in
PCDH19 female epilepsy. Seizure 27: 1-5, 2015.
20150039
Wada T, Takano K, Tsurusaki Y, Miyake N,
Nakashima M, Saitsu H, Matsumoto N, Osaka H : Japanesefamilial case of myoclonus-dystonia syndrome with a splicing
mutation in SGCE. Pediatr Int 57: 324-326, 2015.
20150040
Takano K, Tsuyusaki Y, Sato M, Takagi M, Anzai
R, Okuda M, Iai M, Yamashita S, Okabe T, Aida N, Tsurusaki
Y, Saitsu H, Matsumoto N, Osaka H : A Japanese girl with an
early-infantile onset vanishing white matter disease resembling
Cree leukoencephalopathy. Brain Dev 37: 638-642, 2015.
20150041
Miyake F, Kuroda Y, Naruto T, Ohashi I, Takano
K, Kurosawa K : West syndrome in a patient with SchinzelGiedion syndrome. J Child Neurol 30: 932-936, 2015.

20150042
Murasugi K, Tsukahara T, Washizuka S : The
development and trial of a mediciation discontinuation
program in the department of forensic psychiatry. Ann Gen
Psychiarity 14: 11, 2015.
20150043
Shimizu A, Kobayashi A, Koide N, Suzuki
A, Takeuchi D, Yokoyama T, Motoyama H, Furusawa
N, Tsukahara T, Miyagawa S : Effect of Application of
Subcutaneous Suction Drainage with Subcuticular Sutures for
Wound Closure on the Incidence of Incisional Surgical Site
Infection following Elective General Abdominal Surgery : A
Randomized Controlled Trial. Shinshu Med J 63(2): 91-101,
2015.

Legal Medicine
20150044
Nunotani M, Shiozaki T, Sato N, Kamei S,
Takatsu K, Hayashi T, Ota M, Asamura H : Analysis of 30
insertion-deletion polymorphisms in the Japanese population
using the Investigator DIPplex® kit. Legal Med 17: 467-470,
2015.
20150045
Umemura T, Ota M : Genetic factors affect the
etiology, clinical characteristics and outcome of autoimmune
hepatitis. Clin J Gastroenterol 8: 360-366, 2015.
20150046
Sekiguchi T, Umemura T, Fujimori N, Shibata S,
Ichikawa Y, Kimura T, Joshita S, Komatsu M, Matsumoto A,
Tanaka E, Ota M : Serum cell death biomarkers for predictionof liver fibrosis and poor prognosis in primary biliary cirrhosis.
PLoS ONE 10: e0131658, 2015.
20150047
Oguchi T, Ota M, Ito T, Hamano H, Arakura
N, Katsuyama Y, Meguro A, Kawa S : Investigation ofsusceptibility genes triggering lachrymal/salivary gland lesion
complications in Japanese patients with type I autoimmune
pancreatitis. PLoS ONE 10: e0127078, 2015.
20150048
Carapito R, Shahram F, Michel S, Le Gentil M,
Radosavljevic M, Meguro A, Abdollahi BS, Inoko H, Ota M,
Davatchi F, Bahram S : On the genetics of the Silk Route:association analysis of HLA, and IL10, IL23R-IL12RB2
regions with Behçet's disease in an Iranian population.
Immunogenetics 67: 289-293, 2015.
20150049
Umemura T, Joshita S, Sekiguchi T, Usami Y,
Shibata S, Kimura T, Komatsu M, Matsumoto A, Ota M,
Tanaka E : Serum Wisteria Floribunda agglutinin-positive
Mac-2-binding protein level predicts liver fibrosis andprognosis in primary biliary cirrhosis. Am J Gastorenterol 110:6

857-864, 2015.
20150050
Ozaki Y, Suzuki S, Kashiwase K, Shigenari A,
Okudaira Y, Ito S, Masuya A, Azuma F, Yabe T, Morishima
S, Mitsunaga S, Satake M, Ota M, Morishima Y, Kulski JK,
Saito K, Inoko H, Shiina T : Cost-efficient multiplex PCR
for routine genotyping of up to nine classical HLA loci in asingle analytical run of multiple samples by next generation
sequencing . BMC Genomics 16: 318, 2015.

N, Iwaya M, Maruyama Y, Matsuda K, Arakura N, Tanaka
E, Ota H : Insulin-Like Growth Factor II mRNA-Binding
Protein 3 (IMP3) as a Useful Immunohistochemical Marker
for the Diagnosis of Adenocarcinoma of Small Intestine. Acta
Histochem Cytochem 48: 193-204, 2015.

Internal Medicine 1

20150059
Kamijo N, Matsumoto A, Umemura T, Shibata S,
Ichikawa Y, Kimura T, Komatsu M, Tanaka E : Mutations of
pre-core and basal core promoter before and after hepatitis B
e antigen seroconversion. World J Gastroenterol 21: 541-548,
2015.

20150051
Kitaguchi Y, Fujimoto K, Hotta J, Horie S,
Hirayama J, Hanaoka M : Clinical Characteristics andEmphysema Syndrome and Lung Cancer. J Pulm Respir Med
5: 3, 2015.

20150060
Kanno T, Kamijo Y, Hashimoto K, Kanno Y :Outcomes of blood flow suppression methods of treating highflow access in hemodialysis patients with arteriovenous fistula.
J Vasc Access 16 Suppl 10: S28-S33, 2015.

20150052
Horiuchi T, Ota M, Droma Y, Kobayashi N
Hanaoka M : Gene-gene Interaction Between EPAS1 and
EGLN1 in Patients with High-Altiude Pulmonary Edema.
Shinshu Med J 63: 157-165, 2015.

20150061
Kimura T, Tanaka N, Umemura T, Tanaka
E : Primary hepatocellular carcinoma in a patient withneurofibromatosis type I. Liver Int 35: 2057-2058, 2015.

20150053
Yamamoto H, Yasuo M, Ichiyama T, Ushiki A,
Hanaoka M, Hamano H, Uehara T, Kawakami S, Matsui S,
Kubo K : Cytokine profiles in the BAL fluid of IgG4-related
respiratory disease compared with sarcoidosis. ERJ Open Res
1: 00009-2015, 2015.

Internal Medicine 2
20150054
Akamatsu T, Okamura T, Iwaya Y, Suga T :Screening to Identify and Eradicate Helicobacter pylori
Infection in Teenagers in Japan. Gastroenterol Clin North Am
44: 667-676, 2015.
20150055
Arakura N, Ito T, Tanaka E, Umemura T :Treatment of a Huge Pancreatic Pseudocyst Associatedwith Autoimmune Pancreatitis. Shinshu Med J 63: 417-418,
2015.
20150056
Arakura N, Ito T, Tanaka E, Umemura T :Endoscopic Retrograde Cholangiopancreatography Usinga Multi-bending Duodenoscope in Patients with a Billroth I
Gastrectomy. Shinshu Med J 63: 385-389, 2015.
20150057
Asano J, Watanabe T, Oguchi T, Kanai K,
Maruyama M, Ito T, Muraki T, Hamano H, Arakura N,
Matsumoto A, Kawa S : Association Between Immunoglobulin
G4-related Disease and Malignancy within 12 Years after
Diagnosis: An Analysis after Longterm Followup. J Rheumatol
42: 2135-2142, 2015.
20150058

Daikuhara S, Uehara T, Higuchi K, Hosaka

20150062
Komatsu M, Kimura T, Yazaki M, Tanaka
N, Yang Y, Nakajima T, Horiuchi A, Fang ZZ, Joshita S,
Matsumoto A, Umemura T, Tanaka E, Gonzalez FJ, Ikeda S,
Aoyama T : Steatogenesis in adult-onset type II citrullinemia
is associated with down-regulation of PPARalpha. Biochim
Biophys Acta 1852: 473-481, 2015.
20150063
Maruyama M, Watanabe T, Kanai K, Oguchi
T, Asano J, Ito T, Muraki T, Hamano H, Arakura N,
Uehara T, Kawa S : Extracorporeal shock wave lithotripsy
treatment of pancreatic stones complicated with advanced
stage autoimmune pancreatitis. BMC Gastroenterol 15: 28,
2015.
20150064
M a r u y a m a Y, U e h a r a T, D a i k u h a r a S,
Kobayashi Y, Nakajima T, Matsumoto A, Tanaka E, Ota
H : Clinicopathological characterisation of duodenal
adenocarcinoma with high CD44 variant 9 expression.
Pathology 47: 647-652, 2015.
20150065
Matsumoto A, Yatsuhashi H, Nagaoka S, Suzuki
Y, Hosaka T, Tsuge M, Chayama K, Kanda T, Yokosuka O,
Nishiguchi S, Saito M, Miyase S, Kang JH, Shinkai N, Tanaka
Y, Umemura T, Tanaka E : Factors associated with the effectof interferon-alpha sequential therapy in order to discontinue
nucleoside/nucleotide analog treatment in patients with chronic
hepatitis B. Hepatol Res 45: 1195-1202, 2015.
20150066
Mitsuka Y, Hashimoto T, Takamoto T, Inoue K,
Maruyama Y, Ogata S, Komatsu M, Ikeda S, Takayama T,
Makuuchi M : Living donor liver transplantation using a graftwith periportal fibrosis. Hepatol Res 45: 1248-1250, 2015.

7

20150067
Mizokami M, Yokosuka O, Takehara T, Sakamoto
N, Korenaga M, Mochizuki H, Nakane K, Enomoto H, Ikeda
F, Yanase M, Toyoda H, Genda T, Umemura T, Yatsuhashi
H, Ide T, Toda N, Nirei K, Ueno Y, Nishigaki Y, Betular J,
Gao B, Ishizaki A, Omote M, Mo H, Garrison K, Pang PS,
Knox SJ, Symonds WT, McHutchison JG, Izumi N, Omata
M : Ledipasvir and sofosbuvir fixed-dose combination withand without ribavirin for 12 weeks in treatment-naive andpreviously treated Japanese patients with genotype 1 hepatitis
C: an open-label, randomised, phase 3 trial. Lancet Infect Dis
15: 645-653, 2015.
20150068
Muraki T, Uehara T, Sano K, Oota H, Yoshizawa
A, Asaka S, Tateishi A, Otsuki T, Shingu K, Matoba H,
Kobayashi S, Ichimata S, Watanabe T, Itou T, Tanaka E: A case of MUC5AC-positive intraductal neoplasm of
the pancreas classified as an intraductal tubulopapillary
neoplasm?. Pathol Res Pract 211: 1034-1039, 2015.
20150069
Nagaya T, Tanaka N, Iwaya Y, Jimbo Y, Tatai T,
Ito T, Seki A, Suzawa K, Ochi Y, Hara E, Takata M, Otsuki
T, Iwaya M, Hosaka N, Arakura N, Tanaka E, Hasebe O :Helicobacter pylori-negative Differentiated Adenocarcinomaof the Stomach. Intern Med 54: 2857-2862, 2015.
20150070
Nagaya T, Tanaka N, Kimura T, Kitabatake H,
Fujimori N, Komatsu M, Horiuchi A, Yamaura T, Umemura
T, Sano K, Gonzalez FJ, Aoyama T, Tanaka E : Mechanismof the development of nonalcoholic steatohepatitis afterpancreaticoduodenectomy. BBA Clin 3: 168-174, 2015.
20150071
Nishida N, Ohashi J, Sugiyama M, Tsuchiura T,
Yamamoto K, Hino K, Honda M, Kaneko S, Yatsuhashi H,
Koike K, Yokosuka O, Tanaka E, Taketomi A, Kurosaki M,
Izumi N, Sakamoto N, Eguchi Y, Sasazuki T, Tokunaga K,
Mizokami M : Effects of HLA-DPB1 genotypes on chronic
hepatitis B infection in Japanese individuals. Tissue Antigens
86: 406-412, 2015.
20150072
Oguchi T, Ota M, Ito T, Hamano H, Arakura
N, Katsuyama Y, Meguro A, Kawa S : Investigation ofsusceptibility genes triggering lachrymal/salivary gland lesion
complications in Japanese patients with type 1 autoimmune
pancreatitis. PLoS One 10: e0127078, 2015.
20150073
Okamura T, Komatsu M, Ito A, Ito T, Suga T,
Arakura N, Sakai H, Tanaka E : A case of acquired hemophilia
A diagnosed after percutaneous endoscopic gastrostomy. Clin J
Gastroenterol 8: 290-293, 2015.
20150074
Okamura T, Sakai Y, Hoshino H, Iwaya Y, Tanaka
E, Kobayashi M : Superficially located enlarged lymphoidfollicles characterise nodular gastritis. Pathology 47: 38-44,

2015.
20150075
Pavlidis P, Shums Z, Koutsoumpas AL, Milo J,
Papp M, Umemura T, Lakatos PL, Smyk DS, Bogdanos DP,
Forbes A, Norman GL : Diagnostic and clinical significance of
Crohn's disease-specific anti-MZGP2 pancreatic antibodies by
a novel ELISA. Clin Chim Acta 441: 176-181, 2015.
20150076
Sekiguchi T, Umemura T, Fujimori N, Shibata S,
Ichikawa Y, Kimura T, Joshita S, Komatsu M, Matsumoto A,
Tanaka E, Ota M : Serum cell death biomarkers for predictionof liver fibrosis and poor prognosis in primary biliary cirrhosis.
PLoS One 10: e0131658, 2015.
20150077
Umemura T, Joshita S, Sekiguchi T, Usami Y,
Shibata S, Kimura T, Komatsu M, Matsumoto A, Ota M,
Tanaka E : Serum Wisteria floribunda Agglutinin-Positive
Mac-2-Binding Protein Level Predicts Liver Fibrosis andPrognosis in Primary Biliary Cirrhosis. Am J Gastroenterol 110:
857-864, 2015.
20150078
Yamada S, Okamura T, Kobayashi S, Tanaka
E, Nakayama J : Reduced gland mucin-specific O-glycan ingastric atrophy: A possible risk factor for differentiated-typeadenocarcinoma of the stomach. J Gastroenterol Hepatol 30:
1478-1484, 2015.
20150079
Yuzhe H, Kamijo Y, Hashimoto K, Harada M,
Kanno T, Sugiyama E, Kyogashima M, Oguchi T, Nakajima
T, Kanno Y, Aoyama T : Serum sulfatide abnormality is
associated with increased oxidative stress in hemodialysis
patients. Hemodial Int 19: 429-438, 2015.

Internal Medicine 3
20150080
Echigoya Y, Aoki Y, Miskew B, Panesar D,
Touznik A, Nagata T, Tanihata J, Nakamura A, Nagaraju K,
Yokota T : Long-term efficacy of systemic multiexon skipping
targeting dystrophin exons 45-55 with a cocktail of vivomorpholinos in mdx52 mice. Mol Ther Nucleic Acids 4: e225,2015.
20150081
Ikeda J, Ka toh N, Seki jima Y, Ikeda S :Regression of localized ureter amyloidosis after treatment withsteroids suggested by Tc-99 m pyrophosphate scintigraphy.
Amyloid 22: 257-258, 2015.
20150082
Jin C, Washimi Y, Yoshida K, Hashizume Y,
Yazawa I : Characterization of spheroids in hereditary diffuse
leukoencephalopathy with axonal spheroids. J Neurol Sci 352:
74-78, 2015.
20150083

Katoh N, Matsuda M, Ikeda S : Clinical,

8

endoscopic, and histopathological features of localized
immunoglobulin light chain (AL) amyloidosis in thegastrointestinal tract. Amyloid 22: 254-256, 2015.
20150084
Kinoshita T, Ikeda S : Human papillomavirus(HPV) vaccination: just the facts. Intern Med 54: 1831,2015.
20150085
Kinoshita T, Ikeda S : Human papillomavirus(HPV) vaccination safety assessment: the methods matter.
Intern Med 54: 2533, 2015.

triaxial accelerometer. Cerebellum Ataxias 2: 9, 2015.
20150094
Moriyama M, Fujimoto Y, Rikimaru S, Ushikai
M, Kuroda E, Kawabe K, Takano K, Asakawa A, Inui A,
Eto K, Kadowaki T, Sinasac DS, Okano Y, Yazaki M, Ikeda
SI, Zhang C, Song YZ, Sakamoto O, Kure S, Mitsubuchi H,
Endo F, Horiuchi M, Nakamura Y, Yamamura KI, Saheki T: Mechanism for increased hepatic glycerol synthesis in the
citrin/mitochondrial glycerol-3-phosphate dehydrogenase
double-knockout mouse: Urine glycerol and glycerol
3-phosphate as potential diagnostic markers of human citrin
deficiency. Biochim Biophys Acta 1852: 1787-1795, 2015.

20150086
Kinoshita T, Ikeda S : Peripheral sympathetic
nerve dysfunction in adolescent japanese girls following
immunization with the human papillomavirus vaccine. Intern
Med 54: 1955, 2015.

20150095
Nakamura A : X-linked dilated cardiomyopathy: acardiospecific phenotype of dystrophinopathy. Pharmaceuticals
8: 303-320, 2015.

20150087
Kondo T, Mizuno Y; Japanese Istradefylline
Study Group : A long-term study of istradefylline safety
and eff icacy in patients with Parkinson disease. Clin
Neuropharmacol 38: 41-46, 2015.

20150096
Nishizawa H, Genno H, Shiba N, Nakamura A: Periodic sound-based 6-minute walk test forpatients with
Duchenne muscular dystrophy: a preliminary study. J Phys
Ther Sci 27: 3473-3479, 2015.

20150088
Koyama J, Ikeda S, Ikeda U : Echocardiographic
assessment of the cardiac amyloidoses. Circ J 79: 721-734,
2015.

20150097
Sasaki A, Kakita A, Yoshida K, Konno T, Ikeuchi
T, Hayashi S, Matsuo H, Shioda K : Variable expression of
microglial DAP12 and TREM2 genes in Nasu-Hakola disease.
Neurogenetics 16: 265-276, 2015.

20150089
Koyama J, Minamisawa M, Sekijima Y, Ikeda S,
Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A, Izawa A,
Ikeda U : Left ventricular deformation and torsion assessedby speckle-tracking echocardiography in patients with mutatedtransthyretin-associated cardiac amyloidosis and the effect ofdiflunisal on myocardial function . Int J Cardiol Heart Vasc 9:
1-10, 2015.

20150098
Sato M, Kodaira M, Ishii W, Nakagawa M,
Kishida D, Miyazaki D, Shimojima Y, Matsuda M, Uehara
T, Ikeda S : Multifocal fibrosclerosis with hypertrophic
pachymeningitis and a soft tissue mass around the thoracic
vertebral bodies: a case report with review of the literature.
Intern Med 54: 2267-2272, 2015.

20150090
Kyo M, Mii H, Takekita Y, Tokuhara D, Yazaki
M, Nakamori Y, Kono S, Kinoshita T : Case of adult-onset
type II citrullinemia treated as schizophrenia for a long time.
Psychiatry Clin Neurosci 69: 306-307, 2015.

20150099
Sekijima Y : Transthyretin (ATTR) amyloidosis:
clinical spectrum, molecular pathogenesis and diseasemodifying treatments. J Neurol Neurosurg Psychiatry 86:1036-1043, 2015.

20150091
Lee D, Yun JY, Jeong JH, Yoshida K, Nagasaki
S, Ahn TB : Clinical evolution, neuroimaging, and volumetricanalysis of a patient with a CSF1R mutation who presented
with progressive nonfluent aphasia. Parkinsonism Relat Disord
21: 817-820, 2015.

20150100
Sekijima Y : Transthyretin-type cerebral amyloid
angiopathy: a serious complication in post-transplant patientswith familial amyloid polyneuropathy. J Neurol Neurosurg
Psychiatry 86: 124-124, 2015.

20150092
Manabe S, Hatano M, Yazaki M, Nitta K,
Nagata M : Renal AH amyloidosis associated with atruncated immunoglobulin heavy chain undetectable byimmunostaining. Am J Kidney Dis 66: 1095-1100, 2015.
20150093
Matsushima A, Yoshida K, Genno H, Murata A,
Matsuzawa S, Nakamura K, Nakamura A, Ikeda S : Clinicalassessment of standing and gait in ataxic patients using a

20150101
Sekijima Y, Campos RI, Hammarström P, Nilsson
KP, Yoshinaga T, Nagamatsu K, Yazaki M, Kametani F, Ikeda
S : Pathological, biochemical, and biophysical characteristicsof the transthyretin variant Y114H (p.Y134H) explain its very
mild clinical phenotype. J Peripher Nerv Syst 20: 372-379,
2015.
20150102
Sekijima Y, Tojo K, Morita H, Koyama J, Ikeda
S : Safety and efficacy of long-term diflunisal administration

9in hereditary transthyretin (ATTR) amyloidosis. Amyloid 22:
79-83, 2015.
20150103
Shiba N, Miyazaki D, Yoshizawa T, Fukushima
K, Shiba Y, Inaba Y, Imamura M, Takeda S, Koike K,
Nakamura A : Differential roles of MMP-9 in early and latestages of dystrophic muscles in a mouse model of duchenne
muscular dystrophy. Biochim Biophys Acta 1852: 2170-2182,
2015.
20150104
Tachibana N, Kinoshita M, Kametani F, Tanaka
K, Une Y, Komatsu Y, Kobayashi Y, Ikeda S : Expressionof N-Methyl-D-Aspartate receptor subunits in the bovine
ovum: ova as a potential source of autoantigens causing antiNMDAR encephalitis. Tohoku J Exp Med 235: 223-231,
2015.
20150105
Takeuchi S, Yazaki M, Yamada S, Fukuyama
T, Inui A, Iwasaki Y, Ikeda S : An adolescent case of citrin
deficiency with severe anorexia mimicking anorexia nervosa.
Pediatrics 136: e530-e534, 2015.
20150106
Yabe I, Matsushima M, Yoshida K, Ishikawa K,
Shirai S, Takahashi I, Sasaki H : Rare frequency of downbeat
positioning nystagmus in spinocerebellar ataxia type 31. J
Neurol Sci 350: 90-92, 2015.
20150107
Yahikozawa H, Yoshida K, Sato S, Hanyu N,
Doi H, Miyatake S, Matsumoto N : Predominant cerebellar
phenotype in spastic paraplegia 7(SPG7). Hum Genome Var 2:
15012, 2015.
20150108
Yasunami M, Nakamura H, Agematsu K,
Nakamura A, Yazaki M, Kishida D, Yachie A, Toma
T, Masumoto J, Ida H, Koga T, Kawakami A, Eguchi
K, Furukawa H, Nakamura T, Nakamura M, Migita K: Identification of disease-promoting HLA class i andprotective class II modifiers in japanese patients with familial
mediterranean fever. PLoS One 10: e0125938, 2015.
20150109
Yazaki M, Yoshinaga T, Sekijima Y, Nishio S,
Kanizawa Y, Kametani F, Miyashita K, Hachiya N, Higuchi
K, Ikeda S : The first pure form of ostertag-type amyloidosis
in japan: a sporadic case of hereditary fibrinogen Aα-chain
amyloidosis associated with a novel frameshift variant.
Amyloid 22: 142-144, 2015.
20150110
Yoshinaga T, Nakamura K, Kaneko K, Nakamura
A : A case report of WEBINO syndrome with convergence
impairment. J Neurol Neurophysiol 6: 1, 2015.

Internal Medicine 4
20150111
Takei M, Ishii H, Kawai Y, Kato K, Sekido T, Sato
Y, Takeda T, Komatsu M : Efficacy of oral glucocorticoid andcyclosporine in a case of rituximab-refractory type B insulin
resistance syndrome. J Diabetes Investig 6: 734-738, 2015.
20150112
Ohkubo Y, Sekido T, Sekido K, Nisio S, Suzuki
S, Komatsu M : Triiodothyronine Acts as Protective Factor
against Hyperglycemia Mainly via Thyroid Hormone Receptoralpha. Diabetes 64: A601-A601, 2015.
20150113
Takei M, Komatsu M, Aizawa T : Intracellular
free fatty acid upholds beta-cell glucose competence: The
role of peroxisome proliferator-activated receptor delta andmitochondrial metabolism. J Diabetes Investig 6: 133-136,
2015.
20150114
Shibata Y, Yamazaki M, Takei M, Uchino S,
Sakurai A, Komatsu M : Early-onset, severe, and recurrent
primary hyperparathyroidism associated with a novel CDC73
mutation. Endocr J 62: 627-632, 2015.
20150115
Ishii H, Kobayashi Y, Shibata Y, Miyakoshi
T, Miyakoshi W, Kitahara J, Kato K, Yokota N, Kawai Y,
Komatsu M : The Ratio of Plasma Aldosterone Concentration
to Potassium in Adrenocorticotropin Stimulation Test is a
Possible New Index for Diagnosis of Aldosterone-producing
Adenoma in Patients with Primary Aldosteronism. Shinshu
Med J 63: 145-156, 2015.
20150116
Hamano K, Nakagawa Y, Ohtsu Y, Li L, Medina
J, Tanaka Y, Masuda K, Komatsu M, Kojima I : Lactisole
inhibits the glucose-sensing receptor TIR3 expressed in mousepancreatic beta-cells. J Endocrinol 226: 57-66, 2015.
20150117
Moteki H, Azaiez H, Booth KT, Hattori M, Sato
A, Sato Y, Motobayashi M, Sloan CM, Kolbe DL, Shearer
AE, Smith RJH, Usami S : Hearing loss caused by a P2R2X2
Mutation identified in a MELAS Family with a coexisting
mitochondrial 3243AG mutation. Ann Otol Rhinol Laryngol
124: 177S-183S, 2015.

Internal Medicine 520150118
Shiba Y : New strategy for the treatment of
myocarditis by cell-sheet technology. Circ J 79: 51-52,
2015.
20150119Izawa A, Kashima Y, Miura T, Ebisawa S,
Kitabayashi H, Yamamoto H, Sakurai S, Kagoshima M,
Tomita T, Miyashita Y, Koyama J, Ikeda U : Assessment of

10

Lipophilic vs. Hydrophilic Statin Therapy in Acute Myocardial
Infarction. Circ J 79: 161-168, 2015.
20150120
Abe N, Kashima Y, Izawa A, Motoki H, Ebisawa
S, Miyashita Y, Imamura H, Ikeda U : A 2-year follow-up ofoxidative stress levels in patients with ST-segment elevation
myocardial infarction: A subanalysis of the ALPS-AMI study.
Angiology 66: 271-277, 2015.
20150121
Takeuchi T, Tomita T, Yoshie K, Hioki H, Oguchi
Y, Miura T, Ebisawa S, Motoki H, Okada A, Aizawa K, Izawa
A, Miyashita Y, Koyama J, Ikeda U : Electrocardiographic J
waves are associated with right ventricular morphology andfunction: evaluation by cardiac magnetic resonance imaging.
Heart Vessels 30: 98-107, 2015.
20150122
Hioki H, Miyashita Y, Miura T, Ebisawa S,
Motoki H, Izawa A, Tomita T, Koyama J, Ikeda U : Prognostic
improvement by multidisciplinary therapy in patients withcritical limb ischemia. Angiology 66: 187-194, 2015.
20150123
Takeuchi T, Tomita T, Kasai H, Kashiwagi D,
Yoshie K, Yaguchi T, Oguchi Y, Kozuka A, Gautam M, Motoki
H, Okada A, Shiba Y, Aizawa K, Izawa A, Miyashita Y,
Koyama J, Hongo M, Ikeda U : A young patient with atypical
type-B Wolff-Parkinson-White syndrome accompanied by left
ventricular dysfunction. J Arrhythm 31: 50-54, 2015.
20150124
Pa r k JH, K usu nose K, Motoki H, K won
DH, Grimm RA, Griffin BP, Marwick TH, Popović ZB :Assessment of Right Ventricular Longitudinal Strain in
Patients with Ischemic Cardiomyopathy: Head-to-Head
Comparison between Two-Dimensional Speckle-Based Strain
and Velocity Vector Imaging Using Volumetric Assessment
by Cardiac Magnetic Resonance as a "Gold Standard".
Echocardiography 32: 956-965, 2015.
20150125
Ikeda U, Minamisawa M, Koyama J : Isolated
left ventricular non-compaction cardiomyopathy in adults. J
Cardiol 65: 91-97, 2015.
20150126
Suematsu N, Iida O, Takahara M, Yamauchi
Y, Soga Y, Nakano M, Hirano K, Kawasaki D, Yamaoka T,
Suzuki K, Shintani Y, Miyashita Y, Tazaki J, Meno H, Inou
T : Prognostic Factors in Hemodialysis Patients Undergoing
Endovascular Treatment for Critical Limb Ischemia due to
Isolated Below-the-Knee Disease. J Atheroscler Thromb 22:
404-414, 2015.
20150127
Fujihara M, Yokoi Y, Abe T, Soga Y, Yamashita
T, Miyashita Y, Nakamura M, Yokoi H, Ito S; J-RAS Study
Investigators : Clinical outcome of renal artery stenting for
hypertension and chronic kidney disease up to 12 months in

the J-RAS Study. Circ J 79: 351-359, 2015.
20150128
Okada A, Izawa A, Motoki H, Tomita T,
Miyashita Y, Koyama J, Aizawa K, Shoda M, Ikeda U : Initial
experience of percutaneous extraction of infected cardiac
implantable electric devices using excimer laser. Shinshu Med
J 63: 103-108, 2015.
20150129
Gautam M, Fujita D, Kimura K, Ichikawa H,
Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M,
Ikeda U, Shiba Y : Transplantation of adipose tissue-derived
stem cells improves cardiac contractile function and electricalstability in a rat myocardial infarction model. J Mol Cell
Cardiol 81: 139-149, 2015.
20150130
Koyama J, Ikeda S, Ikeda U : Echocardiographic
assessment of the cardiac amyloidoses. Circ J 79: 721-734,
2015.
20150131
Shiraki T, Iida O, Takahara M, Soga Y, Yamauchi
Y, Hirano K, Kawasaki D, Fujihara M, Utsunomiya M, Tazaki
J, Yamaoka T, Shintani Y, Suematsu N, Suzuki K, Miyashita
Y, Tsuchiya T, Uematsu M : Predictors of Delayed Wound
Healing after Endovascular Therapy of Isolated Infrapopliteal
Lesions Underlying Critical Limb Ischemia in Patients withHigh Prevalence of Diabetes Mellitus and Hemodialysis. Eur J
Vasc Endovasc Surg 49: 565-573, 2015.
20150132
Yamasaki S, Izawa A, Koshikawa M, Saigusa T,
Ebisawa S, Miura T, Shiba Y, Tomita T, Miyashita Y, Koyama
J, Ikeda U : Association between estimated glomerular
filtration rate and peripheral arterial disease. J Cardiol 66: 430434, 2015.
20150133
Hioki H, Miura T, Miyashita Y, Motoki H,
Shimada K, Kobayashi M, Nakajima H, Kimura H, Mawatari
E, Akanuma H, Sato T, Ebisawa S, Ikeda U : Risk stratification
using the CHA2DS2-VASc score in patients with coronary
heart disease undergoing percutaneous coronary intervention;
sub-analysis of SHINANO registry. Int J Cardiol Heart Vasc 7:
76-81, 2015.
20150134
Minamisawa M, Izawa A, Motoki H, Kashima Y,
Hioki H, Abe N, Miura T, Ebisawa S, Miyashita Y, Koyama
J, Ikeda U : Prognostic significance of neuroadrenergic
dysfunction for cardiovascular events in patients with acute
myocardial infarction. Circ J 79: 2238-2245, 2015.
20150135
Miura T, Izawa A, Motoki H, Miyashita Y,
Kashima Y, Ebisawa S, Tomita T, Koyama J, Ikeda U : ClinicalImpact of Rapid Reduction of Low-Density Lipoprotein
Cholesterol Level on Long-Term Outcome of Acute
Myocardial Infarction in the Statin Era: Subanalysis of the11

ALPS-AMI Study. PLoS One 10: e0127835, 2015.
20150136
E b isa w a S, I z a w a A , U e k i Y, H i o k i H,
Minamisawa M, Hashizume N, Abe N, Kashima Y, Miura
T, Takeuchi T, Motoki H, Okada A, Miyashita Y, Koyama
J, Ikeda U : Impact of combination therapy with statin andezetimibe on secondary prevention for post-acute myocardial
infarction patients in the statin era. Int J Cardiol Heart Vasc 8:
154-160, 2015.
20150137
Koyama J, Minamisawa M, Sekijima Y, Ikeda S,
Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A, Izawa A,
Ikeda U : Left ventricular deformation and torsion assessed byspeckle-tracking echocardiography in patients with mutatedtransthyretin-associated cardiac amyloidosis and the effect ofdiflunisal on myocardial function. Int J Cardiol Heart Vasc 9:
1-10, 2015.
20150138
Hioki H, Miura T, Motoki H, Kobayashi H,
Kobayashi M, Nakajima H, Kimura H, Mawatari E, Akanuma
H, Sato T, Ebisawa S, Miyashita Y, Ikeda U, On behalf of
the SHINANO registry investigators : Lean body mass index
prognostic value for cardiovascular events in patients withcoronary artery disease. Heart Asia 7: 12-18, 2015.
20150139
Okada A, Aizawa K, Tomita T, Yoshie K,
Takeuchi T, Shoda M, Ikeda U : Successful transjugular
extraction of a lead in front of the anterior scalene muscle byusing snare technique. J Arrhythm 31: 249-251, 2015.
20150140
Okamoto S, Iida O, Nakamura M, Yamauchi Y,
Fukunaga M, Yokoi Y, Soga Y, Zen K, Hirano K, Suematsu
N, Suzuki K, Shintani Y, Miyashita Y, Urasawa K, Kitano
I, Yamaoka T, Ohura N, Hamasaki T, Uematsu M, Nanto S;
on behalf of the OLIVE Investigators : Postprocedural Skin
Perfusion Pressure Correlates With Clinical Outcomes 1 Year
After Endovascular Therapy for Patients With Critical Limb
Ischemia. Angiology 66: 862-866, 2015.
20150141
Iida O, Nakamura M, Yamauchi Y, Fukunaga
M, Yokoi Y, Yokoi H, Soga Y, Zen K, Suematsu N, Inoue
N, Suzuki K, Hirano K, Shintani Y, Miyashita Y, Urasawa
K, Kitano I, Tsuchiya T, Kawamoto K, Yamaoka T, Uesugi
M, Shinke T, Oba Y, Ohura N, Uematsu M, Takahara M,
Hamasaki T, Nanto S; on behalf of the OLIVE Investigators: 3-Year Outcomes of the OLIVE Registry, a Prospective
Multicenter Study of Patients With Critical Limb Ischemia:
A Prospective, Multi-Center, Three-Year Follow-Up Study on
Endovascular Treatment for Infra-Inguinal Vessel in Patients
With Critical Limb Ischemia. JACC Cardiovasc Interv 8: 14931502, 2015.
20150142

Shiba N, Miyazaki D, Yoshizawa T, Fukushima

K, Shiba Y, Inaba Y, Imamura M, Takeda S, Koike K,
Nakamura A : Differential roles of MMP-9 in early and latestages of dystrophic muscles in a mouse model of Duchenne
muscular dystrophy. Biochim Biophys Acta 1852: 2170-2182,
2015.

Psychiatry
20150143
Hattori K, Ota M, Sasayama D, Yoshida S,
Matsumura R, Miyakawa T, Yokota Y, Yamaguchi S, Noda T,
Teraishi T, Hori H, Higuchi T, Kohsaka S, Goto Y, Kunugi H: Increased cerebrospinal fluid fibrinogen in major depressive
disorder. Sci Rep 5: 11412, 2015.
20150144
Koike S, Kayama T, Arai M, Horiuchi Y, Kobori
A, Miyashita M, Itokawa M, Ogasawara Y : Characterizationof modif ied proteins in plasma f rom a su bt y pe ofschizophrenia based on carbonyl stress: Protein carbonyl is apossible biomarker of psychiatric disorders. Biochem Biophys
Res Commun 467: 361-366, 2015.
20150145
Kouidrat Y, Amad A, Arai M, Miyashita M, Lalau
JD, Loas G, Itokawa M : Advanced glycation end products andschizophrenia: A systematic review. J Psychiatr Res 66-67: 112117, 2015.
20150146
Murasugi K, Tsukahara T, Washizuka S : The
development and trial of a medication discontinuation programin the department of forensic psychiatry. Ann Gen Psychiatry
14: 11, 2015.
20150147
Ogawa S, Hattori K, Sasayama D, Yokota Y,
Matsumura R, Matsuo J, Ota M, Hori H, Teraishi T, Yoshida S,
Noda T, Ohashi Y, Sato H, Higuchi T, Motohashi N, Kunugi H: Reduced cerebrospinal fluid ethanolamine concentration in
major depressive disorder. Sci Rep 5: 7796, 2015.
20150148
Ota M, Noda T, Sato N, Okazaki M, Ishikawa M,
Hattori K, Hori H, Sasayama D, Teraishi T, Sone D, Kunugi H: Effect of electroconvulsive therapy on gray matter volume
in major depressive disorder. J Affect Disord 186: 186-191,
2015.
20150149
Ota M, Noda T, Sato N, Hattori K, Hori H,
Sasayama D, Teraishi T, Nagashima A, Obu S, Higuchi T,
Kunugi H : White matter abnormalities in major depressive
disorder with melancholic and atypical features: A diffusion
tensor imaging study. Psychiatry Clin Neurosci 69: 360-368,
2015.
20150150
Sasaki Y, Usami M, Sasayama D, Okada T,
Iwadare Y, Watanabe K, Ushijima H, Tanaka T, Harada
M, Tanaka H, Kodaira M, Sugiyama N, Sawa T, Saito K :12Concerns expressed by parents of children with pervasive
developmental disorders for different time periods of the day:a case control study. PLoS One 10: e0124692, 2015.
20150151
Sasayama D, Hori H, Nakamura S, Yamamoto
N, Hattori K, Teraishi T, Ota M, Kunugi H : Increased protein
and mRNA expression of resistin after dexamethasone
administration. Horm Metab Res 47: 433-438, 2015.
20150152
Sasaki T, Kinoshita Y, Matsui S, Kakuta S,
Yokota-Hashimoto H, Kinosita K, Iwasaki Y, Kinoshita
T, Yada T, Amano N, Kitamura T : N-methyl-D-aspartate
receptor coagonist D-serine suppresses intake of highpreference food. Am J Physiol Regul Integr Comp Physiol
309: R561-R575, 2015.
20150153
Teraishi T, Hori H, Sasayama D, Matsuo J, Ogawa
S, Ota M, Hattori K, Kajiwara M, Higuchi T, Kunugi H : (13)C-tryptophan breath test detects increased catabolic turnoverof tryptophan along the kynurenine pathway in patients withmajor depressive disorder. Sci Rep 5: 15994, 2015.
20150154
Teraishi T, Hori H, Sasayama D, Matsuo J,
Ogawa S, Ishida I, Nagashima A, kinoshita Y, Ota M, Hattori
K, Higuchi T, Kunuugi H : Personality in remitted major
depressive disorder with single and recurrent episodes assessedwith the Temperament and Character Inventory. Psychiatry
Clin Neurosci 69: 3-11, 2015.
20150155
Usami M, Iwadare Y, Watanabe K, Ushijima H,
Kodaira M, Okada T, Sasayama D, Sugiyama N, Saito K :A case-control study of the difficulties in daily functioning
experienced by children with depressive disorder. J Affect
Disord 179: 167-174, 2015.

Pediatrics
20150156
Motobayashi M, Shigemura T, Tanaka M, Kurata
T, Kobayashi N, Agematsu K, Amano Y, Inaba Y, Koike K,
Nakazawa Y : Cytomegalovirus Encephalitis in a Patient with
Severe Combined Immunodeficiency. J Clin Immunol 35: 689689, 2015.
20150157
Kobayashi N, Kobayashi I, Mori M, Sato S,
Iwata N, Shigemura T, Agematsu K, Yokota S, Koike K :Increased Serum B Cell Activating Factor and a Proliferationinducing Ligand Are Associated with Interstitial Lung Disease
in Patients with Juvenile Dermatomyositis. J Rheumatol 42:
2412-2418, 2015.
20150158
Motobayashi M, Inaba Y, Nishimura T, Kobayashi
N, Nakazawa Y, Koike K : An increase in circulating B cellactivating factor in childhood-onset ocular myasthenia gravis.

Pediatr Neurol 52: 404-409, 2015.
20150159
Shigemura T, Nakazawa Y, Amano Y, Sudo
A, Watanabe M, Kobayashi M, Kobayashi N, Koike K,
Agematsu K, Nishimura K : Subcutaneous abscess due tothe basidiomycete Phellinus mori in a patient with chronic
granulomatous disease. Infection 43: 371-375, 2015.
20150160
Shigemura T, Nakazawa Y, Hirabayashi K,
Kobayashi N, Sakashita K, Agematsu K, Koike K : Dramatic
Improvement in the Multifocal Positron Emission Tomography
Findings of a Young Adult with Chronic Granulomatous
Disease Following Allogeneic Hematopoietic Stem Cell
Transplantation. J Clin Immunol 35: 84-86, 2015.
20150161
Kobayashi N, Takezaki S, Kobayashi I, Iwata N,
Mori M, Nagai K, Nakano N, Miyoshi M, Kinjo N, Murata
T, Masunaga K, Umebayashi H, Imagawa T, Agematsu K,
Sato S, Kuwana M, Yamada M, Takei S, Yokota S, Koike
K, Ariga T : Clinical and laboratory features of fatal rapidly
progressive interstitial lung disease associated with juvenile
dermatomyositis. Rheumatology (Oxford) 54: 784-791,
2015.
20150162
Nakagawa K, Gonzalez-Roca E, Souto A,
Kawai T, Umebayashi H, Campistol JM, Cañellas J, Takei S,
Kobayashi N, Callejas-Rubio JL, Ortego-Centeno N, RuizOrtiz E, Rius F, Anton J, Iglesias E, Jimenez-Treviño S, Vargas
C, Fernandez-Martin J, Calvo I, Hernández-Rodríguez J,
Mendez M, Dordal MT, Basagaña M, Bujan S, Yashiro M,
Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito
MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike
T, Yagüe J, Nishikomori R1, Aróstegui JI : Somatic NLRP3
mosaicism in Muckle-Wells syndrome. A genetic mechanism
shared by different phenotypes of cryopyrin-associatedperiodic syndromes. Ann Rheum Dis 74: 603-610, 2015.
20150163
Chien YH, Abdenur JE, Baronio F, Bannick AA,
Corrales F, Couce M, Donner MG, Ficicioglu C, Freehauf C,
Frithiof D, Gotway G, Hirabayashi K, Hofstede F, Hoganson
G, Hwu WL, James P, Kim S, Korman SH, Lachmann R, Levy
H, Lindner M, Lykopoulou L, Mayatepek E, Muntau A, Okano
Y, Raymond K, Rubio-Gozalbo E, Scholl-Bürgi S, Schulze
A, Singh R, Stabler S, Stuy M, Thomas J, Wagner C, Wilson
WG, Wortmann S, Yamamoto S, Pao M, Blom HJ : Mudd's
disease (MAT I/III deficiency): a survey of data for MAT1A
homozygotes and compound heterozygotes. Orphanet J Rare
Dis 10: 99, 2015.
20150164
Sakashita K, Kato I, Daifu T, Saida S, Hiramatsu
H, Nishinaka Y, Ebihara Y, Ma F, Matsuda K, Saito S,
Hirabayashi K, Kurata T, Uyen LT, Nakazawa Y, Tsuji
K, Heike T, Nakahata T, Koike K : In vitro expansion of

13

CD34(+)CD38(-) cells under stimulation with hematopoietic
growth factors on AGM-S3 cells in juvenile myelomonocytic
leukemia. Leukemia 29: 606-614, 2015.
20150165
Saito S, Yanagisawa R, Yoshikawa K, Higuchi Y,
Koya T, Yoshizawa K, Tanaka M, Sakashita K, Kobayashi T,
Kurata T, Hirabayashi K, Nakazawa Y, Shiohara M, Yonemitsu
Y, Okamoto M, Sugiyama H, Koike K, Shimodaira S : Safety
and tolerability of allogeneic dendritic cell vaccination withinduction of WT1-specific T cells in a pediatric donor andpediatric patient with relapsed leukemia: A case report andreview of the literature. Cytotherapy 17: 330-335, 2015.
20150166
Nishimura T, Inaba Y, Nakazawa Y, Omata T,
Akasaka M, Shirai I, Ichikawa M : Reduction in peripheral
regulatory T cell population in childhood ocular type
myasthenia gravis. Brain Dev 37: 808-816, 2015.
20150167
Motobayashi M, Inaba Y, Fukuyama T, Kurata
T, Niimi T, Saito S, Shiba N, Nishimura T, Shigemura T,
Nakazawa Y, Kobayashi N, Sakashita K, Agematsu K,
Ichikawa M, Koike K : Successf ul treatment for Westsyndrome with severe combined immunodeficiency. Brain Dev
37: 140-144, 2015.
20150168
Wang X, Muramatsu H, Okuno Y, Sakaguchi H,
Yoshida K, Kawashima N, Xu Y, Shiraishi Y, Chiba K, Tanaka
H, Saito S, Nakazawa Y, Masunari T, Hirose T, Elmahdi S,
Narita A, Doisaki S, Ismael O, Makishima H, Hama A, Miyano
S, Takahashi Y, Ogawa S, Kojima S : GATA2 and secondary
mutations in familial myelodysplastic syndromes and pediatricmyeloid malignancies. Haematologica 100: e398-e401,
2015.
20150169
Yanagisawa R, Ishii E, Motoki N, Yamazaki
S, Morita D, Sakashita K, Shiohara M, Tanaka M, Hidaka
Y, Kubota N, Hidaka E, Ogiso Y, Nakamura T,Yasukochi
S : Pretransplant-corrected QT dispersion as a predictor of
pericardial effusion after pediatric hematopoietic stem celltransplantation. Transpl Int 28: 565-574, 2015.
20150170
Shiba N, Miyazaki D, Yoshizawa T, Fukushima
K, Shiba Y, Inaba Y, Imamura M, Takeda S, Koike K,
Nakamura A : Differential roles of MMP-9 in early and latestages of dystrophic muscles in a mouse model of Duchenne
muscular dystrophy. Biochim Biophys Acta 1852: 2170-2182,
2015.
20150171
Akazawa Y, Inaba Y, Hachiya A, Motoki N,
Matsuzaki S, Minatoya K, Morisaki T, Morisaki H, Kosaki
K, Kosho T, Koike K : Reversible cerebral vasoconstriction
syndrome and posterior reversible encephalopathy syndrome
in a boy with Loeys-Dietz syndrome. Am J Med Genet A

167A: 2435-2439, 2015.
20150172
Kano T, Inaba Y, D'Antuono M, Biagini G,
Levésque M, Avoli M : Blockade of in vitro ictogenesis
by low-frequency stimulation coincides with increased
epileptiform response latency. J Neurophysiol 114: 21-28,
2015.
20150173
Biagini G, D'Antuono M, Inaba Y, Kano
T, Ragsdale D, Avoli M : Activity-dependent changes in
excitability of perirhinal cortex networks in vitro. Pflugers
Arch 467: 805-816, 2015.
20150174
Yoshimura-Furuhata M, Nishimura-Tadaki A,
Amano Y, Ehara T, Hamasaki Y, Muramatsu M, Shishido S,
Aikawa A, Hamada R, Ishikura K, Hataya H, Hidaka Y, Noda
S, Koike K, Wakui K, Fukushima Y, Matsumoto N, Awazu M,
Miyake N, Kosho T : Renal complications in 6p duplication
syndrome: Microarray-based investigation of the candidate
gene(s) for the development of congenital anomalies of thekidney and urinary tract (CAKUT) and focal segmental
glomerular sclerosis (FSGS). Am J Mel Genet A 167A: 592601, 2015.
20150175
Ito N, Hataya H, Saida K, Amano Y, Hidaka Y,
Motoyoshi Y, Ohta T, Yoshida Y, Terano C, Iwasa T, Kubota W,
Takada H, Hara T, Fujimura Y, Ito S : Efficacy and safety ofeculizumab in childhood atypical hemolytic uremic syndromein Japan. Clin Exp Nephrol 20: 265-272, 2015.
20150176
H a g i w a r a S, N a k a y a m a Y, Ta g a w a M ,Arai K, Ishige T, Murakoshi T, Sekine T, Abukawa D,
Yamada H, Inoue M, Saito T, Kudo T, Seki Y : Pediatricpatient and parental anxiety and impressions related toinitial gastrointestinal endoscopy: A Japanese multicenterquestionnaire study. Scientif ica (Cairo) 2015: 797564,
2015.

Dermatology
20150177
Sano T, Minagawa A, Koga H, Uhara H,
Okuyama R : Melanocytic naevus shows parallel ridge pattern
due to the melanin columns under the ridges. Acta Derm
Venereol 95: 95-96, 2015.
20150178
Asai Y, Minagawa A, Koga H, Okuyama R :Pigmented macule on the nipple. Clin Exp Dermatol 40: 938940, 2015.
20150179
Nakamura K, Kamijo F, Negishi T, Matsumoto T,
Okuyama R, Uhara H : Primary cutaneous nocardiosis causedby Nocardia concava. J Dermatol 42: 1121-1122, 2015.

14

20150180
Namiki T, Yaguchi T, Nakamura K, Valencia
JC, Coelho SG, Yin L, Kawaguchi M, Vieira WD, Kaneko Y,
Tanemura A, Katayama I, Yokozeki H, Kawakami Y, Hearing
VJ : NUAK2 Amplification Coupled with PTEN Deficiency
Promotes Melanoma Development via CDK Activation.
Cancer Res 75: 2708-2715, 2015.
20150181
Ohmura G, Tsujikawa T, Yaguchi T, Kawamura
N, Mikami S, Sugiyama J, Nakamura K, Kobayashi A, Iwata
T, Nakano H, Shimada T, Hisa Y, Kawakami Y : Aberrant
Myosin 1b Expression Promotes Cell Migration and Lymph
Node Metastasis of HNSCC. Mol Cancer Res 13: 721-731,
2015.
20150182
Ohashi A, Minagawa A, Ashida A, Koga H,
Uhara H, Okuyama R : Histopathological improvement ofscleroderma induced by paclitaxel in a patient with breast
cancer. J Dermatol 42: 1198-1199, 2015.
20150183
Ohashi A, Kiniwa Y, Okuyama R, Kosho T, Suga
T, Has C, Kubo H : A case of Kindler syndrome with severe
esophageal stenosis. Int J Dermatol 54: e106-e108, 2015.
20150184
Shirota S, Minagawa A, Koga H, Momose M,
Uhara H, Okuyama R : Brown nodule on the lower eyelid: aquiz -- lichenoid keratosis. Acta Derm Venereol 95: 1037-1039,
2015.

20150189
Nagaoka T, Kiyohara Y, Koga H, Nakamura A,
Saida T, Sota T : Modification of a melanoma discriminationindex derived f rom hyperspectral data: a clinical trial
conducted in 2 centers between March 2011 and December
2013. Skin Res Technol 21: 278-283, 2015.
20150190
Lallas A, Kyrgidis A, Koga H, Moscarella E,
Tschandl P, Apalla Z, Di Stefani A, Ioannides D, Kittler H,
Kobayashi K, Lazaridou E, Longo C, Phan A, Saida T, Tanaka
M, Thomas L, Zalaudek I, Argenziano G : The BRAAFF
checklist: a new dermoscopic algorithm for diagnosing acralmelanoma. Br J Dermatol 173: 1041-1049, 2015.
20150191
Kiniwa Y, Li J, Wang M, Sun C, Lee JE, Wang
RF, Wang HY : Identification of DRG-1 As a MelanomaAssociated Antigen Recognized by CD4+ Th1 Cells. PLoS One
10: e0124094, 2015.
20150192
Sho ji H, Kiniwa Y, Okuyama R, Yang M,
Higuchi K, Mori M : A nonsense nucleotide substitution in theoculocutaneous albinism II gene underlies the original pinkeyed dilution allele (Oca2(p)) in mice. Exp Anim 64: 171-179,2015.
20150193
Tokuda Y, Arakura F, Uhara H. : Combination
chemotherapy of low-dose 5-fluorouracil and cisplatin foradvanced extramammary Paget's disease. Int J Clin Oncol 20:
194-197, 2015.

20150185
Takazawa Y, Ogawa E, Saito R, Uchiyama R,
Ikawa S, Uhara H, Okuyama R : Notch down-regulation inregenerated epidermis contributes to enhanced expression ofinterleukin-36α and suppression of keratinocyte differentiation
during wound healing. J Dermatol Sci 79: 10-19, 2015.

20150194
Asaka S, Yoshizawa A, Sano K, Uhara H, Honda
T, Ota H : A Case of Vulval Extramammary Paget Disease
With Dermal Invasion Showing Mucinous Carcinoma. Int J
Gynecol Pathol 34: 396-400, 2015.

20150186
Sakaizawa K, Ashida A, Uchiyama A, Ito T,
Fujisawa Y, Ogata D, Matsushita S, Fujii K, Fukushima S,
Shibayama Y, Hatta N, Takenouchi T, Uehara J, Okuyama
R, Yamazaki N, Uhara H: Clinical characteristics associatedwith BRAF, NRAS and KIT mutations in Japanese melanoma
patients. J Dermatol Sci 80: 33-37, 2015.

20150195
Fujisawa Y, Yoshino K, Kiyohara Y, Kadono
T, Murata Y, Uhara H, Hatta N, Uchi H, Matsushita S,
Takenouchi T, Hayashi T, Fujimoto M, Ohara K : The role ofsentinel lymph node biopsy in the management of invasive
extramammary Paget's disease: Multi-center, retrospective
study of 151 patients. J Dermatol Sci 79: 38-42, 2015.

20150187
Minagawa A, Arakura F, Koga H, Tokuda Y,
Koga H, Hashimoto T, Okuyama R : An immunogenetic studyof bullous pemphigoid with mucosal involvement in two
siblings. Eur J Dermatol. 25: 186-188, 2015.

20150196
Yamazaki N, Uhara H, Fukushima S, Uchi
H, Shibagaki N, Kiyohara Y, Tsutsumida A, Namikawa K,
Okuyama R, Otsuka Y, Tokudome T : Phase II study of theimmune-checkpoint inhibitor ipilimumab plus dacarbazine inJapanese patients with previously untreated, unresectable ormetastatic melanoma. Cancer Chemother Pharmacol 76: 969975, 2015.

20150188
Motoyama H, Kobayashi A, Yokoyama T,
Shimizu A, Furusawa N, Sakai H, Kitagawa N, Ashida
A, Okuyama R, Miyagawa S : An initial case report of alaparoscopic spleen-preserving distal pancreatomy for a patientwith a pancreatic metastasis of malignant melanoma. Shinshu
Med J 63: 19-24, 2015.

20150197
Yamazaki N, Kiyohara Y, Uhara H, Fukushima
S, Uchi H, Shibagaki N, Tsutsumida A, Yoshikawa S,
Okuyama R, Ito Y, Tokudome T : Phase II study of ipilimumab
monotherapy in Japanese patients with advanced melanoma.

15

Cancer Chemother Pharmacol 76: 997-1004, 2015.
20150198
Yamazaki N, Kiyohara Y, Sugaya N, Uhara H :Phase I/II study of vemurafenib in patients with unresectableor recurrent melanoma with BRAFV600 mutations. J Dermatol
42: 661-666, 2015.

Radiology
20150199
Nishie A, Kakihara D, Nojo T, Nakamura K,
Kuribayashi S, Kadoya M, Ohtomo K, Sugimura K, Honda H: Current radiologist workload and the shortages in Japan: how
many full-time radiologists are required?. Jpn J Radiol 33: 266272, 2015.

20150205
Robles L, Vaziri ND, Li S, Takasu C, Masuda Y,
Vo K, Farzaneh SH, Stamos MJ, Ichii H : Dimethyl fumarate
ameliorates acute pancreatitis in rodent. Pancreas 44(3): 441447, 2015.
20150206
Takeuchi D, Koide N, Komatsu D, Suzuki A,
Miyagawa S : Prevalence and management of colorectal
neoplasia in surgically treated esophageal cancer patients. Int J
Surg 17: 60-66, 2015.
20150207
Masuda Y, Vaziri ND, Li S, Le A, HajighasemiOssareh M, Robles L, Foster CE, Stamos MJ, Al-AbodullahI, Ricordi C, Ichii H : The effect of Nrf2 pathway activation
on human pancreatic islet cells. PLoS One 10(6): e0131012,
2015.

Surgery 1
20150200
Sugiyama S, Koide N, Takeuchi D, Suzuki
A, Miyagawa S : Clinicopathological characteristics andoutcomes of esophageal submucosal tumors upon treatmentby thoracoscopic enucleation or endoscopic follow up alone.
Esophagus 12: 31-37, 2015.
20150201
Hosoda F, Arai Y, Okada N, Shimizu H,
Miyamoto M, Kitagawa N, Katai H, Taniguchi H, Yanagihara
K, Imoto I, Inazawa J, Ohki M, Shibata T : Integrated genomic
and f unctional analyses reveal glyoxalase I as a novel
metabolic oncogene in human gastric cancer. Oncogene 34(9):1196-1206, 2015.
20150202
Shimizu A, Kobayashi A, Koide N, Ishizone S,
Suzuki A, Takeuchi D, Yokoyama T, Motoyama H, Furusawa
N, Miyagawa S : Effect of Application of Subcutaneous
Suction Drainage Combined with Subcuticular Sutures for
Wound Closure on the Incidence of Incisional Surgical Site
Infection following Elective General Abdominal Surgery: A
Single-Center, Randomized, Open-Label Trial. Shinshu Med J
63(2): 91-101, 2015.
20150203
Shirota T, Ikegami T, Sugiyama S, Kubota K,
Shimizu A, Ohno Y, Mita A, Urata K, Nakazawa Y, Kobayashi
A, Iwaya M, Miyagawa S : Successful living donor livertransplantation for acute liver failure after acetylsalicylic acidoverdose. Clin J Gastroenterol 8(2): 97-102, 2015.
20150204
Motoyama H, Kobayashi A, Yokoyama T,
Shimizu A, Sakai H, Furusawa N, Notake T, Kitagawa N, Arai
T, Yokoi K, Okubo Y, Miyagawa S : Impact of advanced age
on the short- and long-term outcomes in patients undergoinghepatectomy for hepatocellular carcinoma: a single-center
analysis over a 20-year period. Am J Surg 209(4): 733-741,
2015.

20150208
Arai T, Kobayashi A, Yokoyama T, Ohya A,
Fujinaga Y, Shimizu A, Motoyama H, Furusawa N, Sakai
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Kikushima W, Imai A, Toriyama Y, Hirano T,
Murata T, Ishibashi T : Dynamics of Macular Hole Closure in
Gas-Filled Eyes within 24h of Surgery Observed with Swept
Source Optical Coherence Tomography. Ophthalmic Res 53:
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20150304
Toriyama Y, Iesato Y, Imai A, Sakurai T,
Kamiyoshi W, Ichikawa-Shindo Y, Kawate H, Yamauchi A,
Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata
T, Shindo T : Pathophysiological Function of Endogenous
Calcitonin Gene-Related Peptide in Ocular Vascular Diseases.
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20150305

Imai A, Toriyama Y, Iesato Y, Hirano T, Murata T

21: En face swept-source optical coherence tomography detecting
thinning of inner retinal layers as an indicator of capillary
nonperfusion. Eur J Ophthalmol 25: 153-158, 2015.

Otorhinolaryngology
20150306
Moteki H, Kitoh R, Tsukada K, Iwasaki S, Nishio
S, Usami S : The advantages of sound localization and speech
perception of bilateral electric acoustic stimulation. Acta
Otolaryngol 135: 147-153, 2015.
20150307
Nishio S, Hayashi Y, Watanabe M, Usami S :Clinical application of a custom AmpliSeq library and ion
torrent PGM sequencing to comprehensive mutation screening
for deafness genes. Genet Test Mol Biomarkers 19: 209-217,
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20150308
Moteki H, Yoshimura H, Azaiez H, Booth KT,
Shearer AE, Sloan CM, Kolbe DL, Murata T, Smith RJ,
Usami S : USH2 Caused by GPR98 Mutation Diagnosed by
Massively Parallel Sequencing in Advance of the Occurrenceof Visual Symptoms. Ann Otol Rhinol Laryngol 124:
123S-128S, 2015.
20150309
Yoshimura H, Oshikawa C, Nakayama J, Moteki
H, Usami S : Identification of a novel CLRN1 gene mutationin Usher syndrome type 3: two case reports. Ann Otol Rhinol
Laryngol 124: 94S-99S, 2015.
20150310
Yoshimura H, Hashimoto T, Murata T, Fukushima
K, Sugaya A, Nishio S, Usami S : Novel ABHD12 mutations in
PHARC patients: the differential diagnosis of deaf-blindness.
Ann Otol Rhinol Laryngol 124: 77S-83S, 2015.
20150311
Miyagawa M, Nishio S, Sakurai Y, Hattori M,
Tsukada K, Moteki H, Kojima H, Usami S : The patientsassociated with TMPRSS3 mutations are good candidates forelectric acoustic stimulation. Ann Otol Rhinol Laryngol 124:
193S-204S, 2015.
20150312
Iwasa Y, Moteki H, Hattori M, Sato R, Nishio
S, Takumi Y, Usami S : Non-ocular Stickler syndrome with anovel mutation in COL11A2 diagnosed by massively parallel
sequencing in Japanese hearing loss patients. Ann Otol Rhinol
Laryngol 124: 111S-117S, 2015.
20150313
Tsukada K, Ichinose A, Miyagawa M, Mori K,
Hattori M, Nishio S, Naito Y, Kitajiri S, Usami S : Detailed
hearing and vestibular profiles in the patients with COCH
mutations. Ann Otol Rhinol Laryngol 124: 100S-110S,
2015.
20150314

Miyagawa M, Nishio S, Hattori M, Takumi Y,

Usami S : Germinal mosaicism in a family with BO syndrome.
Ann Otol Rhinol Laryngol 124: 118S-122S, 2015.
20150315
Mori K, Moteki H, Kobayashi Y, Azaiez H,
Booth KT, Nishio S, Sato H, Smith RJ, Usami S : Mutations in
LOXHD1 gene cause various types and severities of hearing
loss. Ann Otol Rhinol Laryngol 124: 135S-141S, 2015.
20150316
Mori K, Miyanohara I, Moteki H, Nishio S,
Kurono Y, Usami S : Novel mutation in GRXCR1 at DFNB25
lead to progressive hearing loss and dizziness. Ann Otol Rhinol
Laryngol 124: 129S-134S, 2015.
20150317
Nishio S, Hattori M, Moteki H, Tsukada K,
Miyagawa M, Naito T, Yoshimura H, Iwasa Y, Mori K, Shima
Y, Sakuma N, Usami S : Gene expression profiles of thecochlea and vestibular endorgans: localization and functionof genes causing deafness. Ann Otol Rhinol Laryngol 124:
6S-48S, 2015.
20150318
Moteki H, Azaiez H, Booth KT, Hattori M, Sato
A, Sato Y, Motobayashi M, Sloan CM, Kolbe DL, Shearer AE,
Smith RJ, Usami S : Hearing loss caused by a P2RX2 mutation
identified in a MELAS family with a coexisting mitochondrial
3243AG mutation. Ann Otol Rhinol Laryngol 124: 177S-183S,
2015.
20150319
Ichinose A, Moteki H, Hattori M, Nishio S, Usami
S : Novel mutations in LRTOMT associated with moderate
progressive hearing loss in autosomal recessive inheritance.
Ann Otol Rhinol Laryngol 124: 142S-147S, 2015.
20150320
Nishio S, Usami S : Deafness gene variations
in a 1120 nonsyndromic hearing loss cohort: molecularepidemiology and deafness mutation spectrum of patients inJapan. Ann Otol Rhinol Laryngol 124: 49S-60S, 2015.
20150321
Miyagawa M, Nishio S, Ichinose A, Iwasaki
S, Murata T, Kitajiri S, Usami S : Mutational spectrum andclinical features of patients with ACTG1 mutations identified
by massively parallel DNA sequencing. Ann Otol Rhinol
Laryngol 124: 84S-93S, 2015.
20150322
Sakuma N, Moteki H, Azaiez H, Booth KT,
Takahashi M, Arai Y, Shearer AE, Sloan CM, Nishio S, Kolbe
DL, Iwasaki S, Oridate N, Smith RJ, Usami S : Novel PTPRQ
mutations identified in three congenital hearing loss patientswith various types of hearing loss. Ann Otol Rhinol Laryngol
124: 184S-192S, 2015.
20150323
Moteki H, Shearer AE, Izumi S, Kubota Y, Azaiez
H, Booth KT, Sato A, Sloan CM, Kolbe DL, Shearer AE, Smith
RJ, Usami S : De novo mutation in X-linked hearing loss-

22

associated POU3F4 in a sporadic case of congenital hearing
loss. Ann Otol Rhinol Laryngol 124: 169S-176S, 2015.
20150324
Miyagawa M, Nishio S, Hattori M, Moteki H,
Kobayashi Y, Saton H, Watanabe T, Naito Y, Oshikawa C,
Usami S : Mutations in the MYO15A gene are a significant
cause of nonsyndromic hearing loss: massively parallel DNA
sequencing-based analysis. Ann Otol Rhinol Laryngol 124:
158S-168S, 2015.
20150325
Tsukada K, Fukuoka H, Usami S : Vestibularfunctions of hereditary hearing loss patients with GJB2
mutations. Audiol Neurootol 20(3): 147-152, 2015.

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Ke H, Suzuki A, Miyamoto T, Kashima H,
Shiozawa T : 4-hydroxy estrogen induces DNA damage oncodon 130/131 of PTEN in endometrial carcinoma cells. Mol
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Asaka R, Miyamoto T, Yamada Y, Ando H,
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Anesthesiology and Resuscitology
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Tsukada K, Nishio S, Hattori M, Usami S :Ethnic-specific spectrum of GJB2 and SLC26A4 mutations:
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20150327
Miyagawa M, Nishio S, Kumakawa K, Usami S: Massively parallel DNA sequencing successfully identified
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20150328
Suzuki N, Okamura K, Yano T, Moteki H, Kitoh
R, Takumi Y, Usami S : Silicone impression material foreign
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Taniguchi M, Matsuo H, Shimizu S, Nakayama
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Gavilan J, Adunka O, Aqrawal S, etc.44 Usami
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Obstetrics and Gynecology
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Kashima H, Wu RC, Wang Y, Sinno AK,
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Kobayashi Y, Kashima H, Wu RC, Jung JG, Kuan
JC, Gu J, Xuan J, Sokoll L, Visvanathan K, Shih IeM, Wang
TL : Mevalonate Pathway Antagonist Suppresses Formationof Serous Tubal Intraepithelial Carcinoma and Ovarian
Carcinoma in Mouse Models. Clin Cancer Res 21(20): 4652-

20150335
Sugiyama Y, Shimizu F, Shimizu S, Urasawa M,
Tanaka S, Kawamata M : Severe Re-expansion Pulmonary
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Gotoh S, Sugiyama D, Imai E, Kawamata M: Difficulty with cuff deflation of reinforced tracheal tube
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Ishida T, Sakamoto A, Tanaka H, Ide S, Ishida K,
Tanaka S, Mori T, Kawamata M : Transversus abdominis plane
block with 0.25% levobupivacaine: a prospective, randomized,
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20150338
Tanaka H, Kawamata T, Gen-No H, Nose
H, Kawamata M : Evaluation of the Physical Activity ofAnesthesiologists in the Operating Room During Daily Work
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20150339
Bidur Baral K, Ide S, Uzawa M, Kiyosawa K,
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20150340
Kawai Y, Ajima K, Kaidoh M, Sakaguchi M,
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Ishida T, Kiuchi C, Sekiguchi T, Tsujimoto T,
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23

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Plastic and Reconstructive Surgery
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20150351
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Emergency and Critical Care Medicine
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Nitta K, Imamura H, Mochizuki K, Takayama H: A foreign body in the nasopharynx: missing tooth mystery
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20150347
Abe N, Kashima Y, Izawa A, Motoki H, Ebisawa
S, Miyashita Y, Imamura H, Ikeda U : A 2-year follow-up ofoxidative stress levels in patients with ST-segment elevation
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Comprehensive Cancer Therapy
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Koizumi T, Fukushima T, Tatai T, Kobayashi T,
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20150354
Shimodaira S, Higuchi Y, Koya T, Kobayashi T,
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Brain Disease Research
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24

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20150366
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20150360
Makanga JO, Kobayashi M, Ikeda H, ChristiantoA, Yamada M, Kawasaki T, Inazu T : Generation of Rat
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Lower Urinary Tract Medicine
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Home-Care Promotion
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Yoshinaga T, Nakamura K, Kaneko K, Nakamura

25

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Center for Medical Education and ClinicalTraining
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Aging Biology
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Neuroplasticity
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Molecular Oncology
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26

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activation by mitochondrial oxidative stress in macrophages
leads to the development of angiotensin II-induced aortic
aneurysm. Arterioscler Thromb Vasc Biol 35: 127-136,
2015.
20150391
Shirasuna K, Karasawa T, Usui F, Kobayashi M,
Komada T, Kimura A, Ohkuchi A, Taniguchi S, Takahashi
M : NLRP3 Deficiency Improves Angiotensin II-Induced
Hypertension But Not Fetal Growth Restriction During
Pregnancy. Endocrinology 156: 4281-4292, 2015.
20150392
Kadoya H, Satoh M, Sasaki T, Taniguchi S,
Takahashi M, Kashihara N : Excess aldosterone is a criticaldanger signal for inflammasome activation in the developmentof renal fibrosis in mice. FASEB J 29: 3899-3910, 2015.
20150393
Harada N, Amano J : Obligate Anaerobic
Lactobacillus Casei KJ686 Selectively Targets Solid Tumors
and Exihibits an Antitumor Effect. Shinshu Med J 63: 375-384,
2015.

Molecular Pathology
20150394
Okamura T, Sakai Y, Hoshino H, Iwaya Y, Tanaka
E, Kobayashi M : Superficially located enlarged lymphoidfollicles characterise nodular gastritis. Pathology 47: 38-44,
2015.
20150395
Takayama Y, Nobusawa S, Ochiai I, Watanabe
H, Ishigame H, Ikota H, Hirato J, Nakayama J, Yokoo H :Malignant meningioma with adenocarcinoma-like metaplasia:
Demonstration of intestinal phenotype. Neuropathology 35:
158-164, 2015.
20150396
Yamanoi K, Sekine S, Higuchi K, Kushima R,
Nakayama J : Decreased expression of gastric gland mucinspecific glycan α1,4-linked N-acetylglucosamine on its scaffold
mucin 6 is associated with malignant potential of pyloric
gland adenoma of the stomach. Histopathology 67: 898-904,
2015.
20150397
Yamada S, Okamura T, Kobayashi S, Tanaka
E, Nakayama J : Reduced gland mucin-specific O-glycan ingastric atrophy is a possible risk factor for differentiated-typeadenocarcinoma of the stomach. J Gastroenterol Hepatol 30:
1478-1484, 2015.

20150398
Zhang Y, Nakayama J, Kamata T : Nox4generated ROS regulate TGF-β1-induced motility of coloncancer cells through the low molecular weight protein tyrosine
phosphatase-Rho signaling pathway. Shinshu Med J 63: 281293, 2015.
20150399
Kawakubo M, Ito Y, Fukuda M, Nakayama J :Helicobacter pylori. Taniguchi N, Endo T, Hart G, Seeberger
P, Wong CH (eds.) : Glycoscience: Biology and Medicine. 723729, Springer Japan, Tokyo, 2015.

Metabolic Regulation
20150400
Komatsu M, Kimura T, Yazaki M, Tanaka
N, Yang Y, Nakajima T, Horiuchi A, Fang ZZ, Joshita S,
Matsumoto A, Umemura T, Tanaka E, Gonzalez FJ, Ikeda S,
Aoyama T : Steatogenesis in adult-onset type II citrullinemia isassociated with down-regulation of PPARα. Biochim Biophys
Acta 1852: 473-481, 2015.
20150401
Tanaka N, Takahashi S, Zhang Y, Krausz KW,
Smith PB, Patterson AD, Gonzalez FJ : Role of fibroblast
growth factor 21 in the early stage of NASH induced bymethionine- and choline-deficient diet. Biochim Biophys Acta
1852: 1242-1252, 2015.
20150402
Tanaka N, Takahashi S, Matsubara T, Jiang C,
Sakamoto W, Chanturiya T, Teng R, Gavrilova O, Gonzalez FJ: Adipocyte-specific disruption of fat-specific protein 27 causes
hepatosteatosis and insulin resistance in high-fat diet-fed mice.
J Biol Chem 290: 3092-3105, 2015.
20150403
Nagaya T, Tanaka N, Kimura T, Kitabatake H,
Fujimori N, Komatsu M, Horiuchi A, Yamaura T, Umemura
T, Sano K, Gonzalez FJ, Aoyama T, Tanaka E : Mechanismof the development of nonalcoholic steatohepatitis afterpancreaticoduodenectomy. BBA Clin 3: 168-174, 2015.
20150404
Yuzhe H, Kamijo Y, Hashimoto K, Harada M,
Kanno T, Sugiyama E, Kyogashima M, Oguchi T, Nakajima
T, Kanno Y, Aoyama T : Serum sulfatide abnormality is
associated with increased oxidative stress in hemodialysis
patients. Hemodial Int 19: 429-438, 2015.
20150405
Xu MJ, Cai Y, Wang H, Altamirano J, Chang B,
Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara
T, Mukhopadhyay P, Kimura S, Pacher P, Gonzalez FJ,
Bataller R, Gao B : Fat-specific protein 27/CIDEC promotes
development of alcoholic steatohepatitis in mice and humans.
Gastroenterology 149: 1030-1041, 2015.
20150406
Jiang C, Xie C, Li F, Zhang L, Nichols RG,
Krausz KW, Cai J, Qi Y, Fang ZZ, Takahashi S, Tanaka

27

N, Desai D, Amin SG, Albert I, Patterson AD, Gonzalez
FJ : Intestinal farnesoid X receptor signaling promotes
nonalcoholic fatty liver disease. J Clin Invest 125: 386-402,
2015.

20150415
Koyama T, Sakurai T, Kamiyoshi A, IchikawaShindo Y, Kawate H, Shindo T : Adrenomedullin-RAMP2
system in vascular endothelial cells. J Atheroscler Thromb 22:
647-653, 2015.

20150407
Zhang L, Nichols RG, Correll J, Murray IA,
Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert
I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD :Persistent organic pollutants modify gut microbiota-hostmetabolic homeostasis in mice through aryl hydrocarbon
receptor activation. Environ Health Perspect 123: 679-688,
2015.

Sports Medical Sciences
20150416
Masuki S, Sumiyoshi E, Nose H : Vasopressin
V1a receptor gene and voluntary exercise: Insights fromhumans and animal models. The journal of physical fitness andsports medicine 4: 271-278, 2015.

20150408
Fang ZZ, Tosh DK, Tanaka N, Wang H, Krausz
KW, O'Connor R, Jacobson KA, Gonzalez FJ : Metabolic
mapping of A3 adenosine receptor agonist MRS5980. Biochem
Pharmacol 97: 215-223, 2015.

20150417
Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K,
Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H,
Higuchi K, Nakajima K, Taniguchi S : NFkB2 gene as a novel
candidate that epigenetically responds to interval walking
training. Int J Sports Med 36(9): 769-775, 2015.

20150409
Manna SK, Golla S, Golla JP, Tanaka N, Cai Y,
Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez
FJ : St. John's wort attenuates colorectal carcinogenesis in micethrough suppression of inflammatory signaling. Cancer Prev
Res (Phila) 8: 786-795, 2015.

20150418
Masuki S, Mori M, Tabara Y, Sakurai A,
Hashimoto S, Morikawa M, Miyagawa K, Sumiyoshi E, Miki
T, Higuchi K, Nose H : The factors affecting adherence to along-term interval walking training program in middle-aged
and older people. J Appl Physiol 118: 595-603, 2015.

20150410
Horiuchi A, Hosoi K, Kajiyama M, Tanaka N,
Sano K, Graham DY : Prospective, randomized comparisonof 2 methods of cold snare polypectomy for small colorectal
polyps. Gastrointest Endosc 82: 686-692, 2015.

20150419
Masuki S, Sumiyoshi E, Nose H : Vasopressin
V1a Receptor Gene and Voluntary Exercise in Humans andMice. Kanosue K, Oshima S, Cao ZB, Oka K eds. : Physical
Activity, Exercise, Sedentary Behavior and Health. 251-262,
Springer Japan, Tokyo, 2015.

20150411
Horiuchi A, Makino T, Ichise Y, Kajiyama M,
Kato N, Tanaka N : Comparison of newly found polyps after
removal of small colorectal polyps with cold or hot snare
polypectomy. Acta Gastroenterol Belg 78: 406-410, 2015.
20150412
Kimura T, Tanaka N, Umemura T, Tanaka
E : Primary hepatocellular carcinoma in a patient withneurofibromatosis type I. Liver Int 35: 2057-2058, 2015.
20150413
Nagaya T, Tanaka N, Iwaya Y, Jimbo Y, Tatai T,
Ito T, Seki A, Suzawa K, Ochi Y, Hara E, Takata M, Otsuki
T, Iwaya M, Hosaka N, Arakura N, Tanaka E, Hasebe O :Helicobacter pylori-negative differentiated adenocarcinoma of
the stomach. Intern Med 54: 2857-2862, 2015.

Health Education and Psychology
20150420
Maruo SJ, Sanongdetch W, Choeychom S,
Chansirikarn S, Thrakul S, Phuphaibul R, Phuphaibul S,
Terasawa S, Nakade K, Watanabe T, Murata Y, Terasawa K :Comparing the Effectiveness of Health Program in Thailand
and Japan. J Nurs Care 4(5): 298, 2015.
20150421
Watanabe T, Terasawa K, Nakade K, Murata Y,
Terasawa S, Nemoto K, Kobayashi T, Nakajima K, Zhang
Y, Maruo S, Sasamori F, Hirota N, Okuhara M : Difference
between Two Japanese Health Promotion Programs on
Measures of Health and Wellness. Innovative Journal of
Medical and Health Science 5(4): 170-181, 2015.

Cardiovascular Research
20150414
Toriyama Y, Iesato Y, Imai A, Sakurai T,
Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A,
Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata
T, Shindo T : Pathophysiological function of endogenous
calcitonin gene-related peptide in ocular vascular diseases. Am
J Pathol 185: 1783-1794, 2015.

20150422
Murata Y, Nemoto K, Kobayashi I, Miyata Y,
Terasawa S, Sasamori F, Nakajima K, Hirota N, Kobayashi
T, Yong Z, Watanabe T, Okuhara M, Keisuke N, Maruo SJ,
Terasawa K : Effect of a Two-year Health Program on Brain
Function, Physical Fitness and Blood Chemistry. J Community
Med Health Educ 5(3): 349, 2015.
20150423

Murata Y, Watanabe T, Terasawa S, Nakajima

28

K, Kobayashi T, Yong Z, Okuhara M, Nakade K, Terasawa
K : Moderate Exercise Improves Cognitive Performanceand Decreases Cortical Activation in Go/No-Go Task. BAOJ
Medical and Nursing 1(1): 002, 2015.
20150424
Murata Y, Tabuch H, Watanabe T, Terasawa S,
Nakajima K, Kobayashi T, Yong Z, Okuhara M, Nakade K,
Maruo SJ, Terasawa K : Comparison of Cortical Activation
during Subtraction in Mental Calculation and with a
Calculator. Biochem Anal Biochem 4(3): 185, 2015.
20150425Fu jimori S, Terasawa K, Murata Y, Ogawa
K, Tabuchi H, Yanagisawa H, Terasawa S, Shinohara K,
Yanagisawa A : Comparison of Cortical Activation during
Mahjong Game Play in a Video Game Setting and a Real-life
Setting. Biochem Anal Biochem 4(2): 164, 2015.

outcome of deep-seated atypical lipomatous tumor of theextremities with median-term follow-up study. Eur J Surg
Oncol 41(3): 400-406, 2015.
20150432
Tachibana N, Kinoshita M, Kametani F, Tanaka
K, Une Y, Komatsu Y, Kobayashi Y, Ikeda S : Expressionof N-Methyl-D-Aspartate Receptor Subunits in the Bovine
Ovum: Ova as a Potential Source of Autoantigens Causing
Anti-NMDAR Encephalitis. Tohoku J Exp Med 235(3): 223231, 2015.
20150433
Shimizu A, Kobayashi A, Motoyama H, Sakai H,
Yamada A, Yoshizawa A, Momose M, Kadoya M, Miyagawa
SI : Features of Acute Liver Congestion on Gadoxetate
Disodium-Enhanced MRI in a Rat Model: Role of OrganicAnion-Transporting Polypeptide 1A1. J Magn Reson Imaging
42(3): 828-836, 2015.

Laboratory Medicine
20150426
Kobayashi M, Horikawa M, Uehara T, Honda T,
Kobayashi T, Sakai H : Flower-like/clover leaf lymphocytes
appear in various diseases: Cerebrospinal fluid cytology casewith review of the literature. Diagn Cytopathol 43(1): 88-90,2015.
20150427
Horiuchi K, Matsumoto T, Ota Y, Kasuga E,
Negishi T, Yaguchi T, Sugano M, Honda T : Addition ofthymidine to culture media for accurate examination ofthymidine-dependent small-colony variants of methicillinresistant Staphylococcus aureus: A pilot study. J Microbiol
Methods 110: 40-44, 2015.
20150428
Yanagisawa S, Soyano A, Igarashi H, Ura M,
Nakamura Y : Effect of a maternal and child health handbook
on maternal knowledge and behaviour: a community-based
controlled trial in rural Cambodia. Health Policy Plan 30(9):1184-1192, 2015.
20150429
Ikeda M, Arai S, Mukai S, Takezawa Y, Terasawa
F, Okumura N : Novel heterozygous dysfibrinogenemia,
Sumida (AαC472S), showed markedly impaired lateralaggregation of protofibrils and mildly lower functional
fibrinogen levels. Thromb Res 135(4): 710-717, 2015.
20150430
Taira C, Matsuda K, Yamaguchi A, Uehara M,
Sugano M, Okumura N, Honda T : Rapid single nucleotide
polymorphism based method for hematopoietic chimerism
analysis and monitoring using high-speed droplet allelespecific PCR and allele-specific quantitative PCR. Clin Chim
Acta 445: 101-106, 2015.
20150431
Kito M, Yoshimura Y, Isobe K, Aoki K, Momose
T, Suzuki S, Tanaka A, Sano K, Akahane T, Kato H : Clinical20150434
Ota H, Yamaguchi D, Iwaya M, Kobayashi M,
Tateiwa N, Iwaya Y, Momose M, Uehara T : Principal cells ingastric neoplasia of fundic gland (chief cell predominant) typeshow characteristics of immature chief cells. Pathol Int 65(4):202-204, 2015.
20150435
Nakamura K, Kamijo F, Negishi T, Matsumoto T,
Okuyama R, Uhara H : Primary cutaneous nocardiosis causedby Nocardia concava. J Dermatol 42(11): 1121-1122, 2015.
20150436
Tooyama H, Matsumoto T, Hayashi K, Kurashina
K, Kurita H, Uchida M, Kasuga E, Honda T : Candida
concentrations determined following concentrated oral rinse
culture reflect clinical oral signs. BMC Oral Health 15: 150,
2015.
20150437
Mukai S, Ikeda M, Takezawa Y, Sugano M,
Honda T, Okumura N : Differences in the function andsecretion of congenital aberrant fibrinogenemia between
heterozygous γD320G(Okayama II) and γΔN319-ΔD320(Otsu
I). Thromb Res 136: 1318-1324, 2015.
20150438
Komatsu M, Yasuo M, Kobayashi N, Tateishi
K, Ushiki A, Urushihata K, Yamamoto H, Hanaoka M,
Matoba H, Honda T, Ichikawa K : Hypertrophic Pulmonary
Osteoarthropathy in Anaplastic Lymphoma Kinase (ALK)positive Lung Cancer. Intern Med 54(16): 2045-2049,
2015.
20150439
Yamaguchi A, Matsuda K, Sueki A, Taira C,
Uehara M, Saito Y, Honda T : Development of a rapid andsensitive one-step reverse transcription-nested polymerase
chain reaction in a single tube using the droplet-polymerase
chain reaction machine. Clin Chim Acta 448: 150-154,
2015.

29

20150440
Saida K, Kawasaki K, Hirabayashi K, Akazawa
Y, Kubota S, Kasuga E, Kusakari M,Ishida T, Kitamura M,
Baba A, Koike K : Exfoliative toxin A staphylococcal scalded
skin syndrome in preterm infants. Eur J Pediatr 174(4): 551555, 2015.
20150441
Hayashi T, Horiuchi A, Sano K, Kanai Y, Yaegashi
N, Aburatani H, Konishi I : Biological characterization of soft
tissue sarcomas. Ann Transl Med 3(22): 368, 2015.
20150442
Kito M, Yoshimura Y, Isobe K, Aoki K, Momose
T, Suzuki S, Tanaka A, Sano K,Akahane T, Kato H : Clinicaloutcome of deep-seated atypical lipomatous tumor of theextremities with median-term follow-up study. Eur J Surg
Oncol 41(3): 400-406, 2015.
20150443
Shimodaira S, Sano K, Hirabayashi K, Koya T,
Higuchi Y, Mizuno Y, Yamaoka N, Yuzawa M, Kobayashi T,
Ito K, Koizumi T : Dendritic Cell-Based Adjuvant Vaccination
Targeting Wilms' Tumor 1 in Patients with Advanced
Colorectal Cancer. Vaccines (Basel) 3(4): 1004-1018, 2015.
20150444
Nagaya T, Tanaka N, Kimura T, Kitabatake H,
Fujimori N, Komatsu M, Horiuchi A,Yamaura T, Umemura
T, Sano K, Gonzalez FJ, Aoyama T, Tanaka E : Mechanismof the development of nonalcoholic steatohepatitis afterpancreaticoduodenectomy. BBA Clin 3: 168-174, 2015.
20150445
Kobayashi S, Tsukadaira A, Kobayashi S,
Izumiyama S, Yoon HS : Amoebic encephalitis in a farmer.
Pathology 47(7): 720-722, 2015.
20150446
Urata K, Ikegami T, Nakazawa Y, Ohno Y,
Kobayashi A, Mita A, Sano K, Kurozumi M, Miyagawa S :Living-Donor Liver Transplantation for Hepatic Metastasis
From Meningeal Hemangiopericytoma: A Case Report.
Transplant Proc 47(7): 2274-2277, 2015.
20150447
Yanagisawa R, Nakamura T, Ogiso Y, Hachiya
A, Fujihara I, Morita D, Sakashita K, Kitamura M, Matsui
H, Nishijima F, Hayashi H, Hidaka E, Sano K, Shiohara
M, Yasukochi S : Interleukin-8-producing primary cardiac
undifferentiated sarcoma in a child with sustained fever.
Pediatr Int 57(4): 742-745, 2015.
20150448
Sakai K, Shimodaira S, Maejima S, Udagawa
N, Sano K, Higuchi Y, Koya T, Ochiai T, Koide M, Uehara
S, Nakamura M, Sugiyama H, Yonemitsu Y, Okamoto M,
Hongo K : Dendritic cell-based immunotherapy targetingWilms' tumor 1 in patients with recurrent malignant glioma. J
Neurosurg 123(4): 989-997, 2015.
20150449

Horiuchi A, Hosoi K, Kajiyama M, Tanaka N,

Sano K, Graham DY : Prospective, randomized comparisonof 2 methods of cold snare polypectomy for small colorectal
polyps. Gastrointest Endosc 82(4): 686-692, 2015.
20150450
Sakaizawa T, Yoshizawa A, Nishimura H,
Arimura T, Kobayashi N, Ozawa K, Asaka S, Yoshida K,
Hirai K, Hosaka N : A Case of Pulmonary Squamous Cell
Carcinoma Revealed Ground Glass Opacity on Computed
Tomography. J Thorac Oncol 10(8): 1229-1230, 2015.
20150451
Asaka S, Yoshizawa A, Sano K, Uhara H, Honda
T, Ota H : A Case of Vulval Extramammary Paget Disease
With Dermal Invasion Showing Mucinous Carcinoma. Int J
Gynecol Pathol 34(4): 396-400, 2015.
20150452
Sato M, Kodaira M, Ishii W, Nakagawa M,
Kishida D, Miyazaki D, Shimojima Y, Matsuda M, Uehara
T, Ikeda S : Multifocal Fibrosclerosis with Hypertrophic
Pachymeningitis and a Soft Tissue Mass around the Thoracic
Vertebral Bodies: A Case Report with Review of the Literature.
Intern Med 54(17): 2267-2272, 2015.
20150453
Del Portillo A, Lagana SM, Yao Y, Uehara T,
Jhala N, Ganguly T, Nagy P, Gutierrez J, Luna A, Abrams
J, Liu Y, Brand R, Sepulveda JL, Falk GW, Sepulveda AR :Evaluation of Mutational Testing of Preneoplastic Barrett's
Mucosa by Next-Generation Sequencing of Formalin-Fixed,
Paraffin-Embedded Endoscopic Samples for Detection ofConcurrent Dysplasia and Adenocarcinoma in Barrett's
Esophagus. J Mol Diagn 17(4): 412-419, 2015.
20150454
Minagawa T, Kato H, Ogawa T, Uehara T,
Ishizuka O : Usefulness of sonourethrography for penile
abscess as a result of xanthogranulomatous granuloma in the
corpus cavernosum of an adult: A case report. Int J Urol 22(8):788-790, 2015.
20150455
Maruyama M, Watanabe T, Kanai K, Oguchi
T, Asano J, Ito T, Muraki T, Hamano H, Arakura N,
Uehara T, Kawa S : Extracorporeal shock wave lithotripsy
treatment of pancreatic stones complicated with advanced
stage autoimmune pancreatitis. BMC Gastroenterol 15: 28,
2015.
20150456
Muraki T, Uehara T, Sano K, Oota H, Yoshizawa
A, Asaka S, Tateishi A, Otsuki T, Shingu K, Matoba H,
Kobayashi S, Ichimata S, Watanabe T, Itou T, Tanaka E :A case of MUC5AC-positive intraductal neoplasm of thepancreas classified as an intraductal tubulopapillary neoplasm?
. Pathol Res Pract 211(12): 1034-1039, 2015.
20150457
Daikuhara S, Uehara T, Higuchi K, Hosaka
N, Iwaya M, Maruyama Y, Matsuda K, Arakura N, Tanaka

30

E, Ota H : Insulin-Like Growth Factor II mRNA-Binding
Protein 3 (IMP3) as a Useful Immunohistochemical Marker
for the Diagnosis of Adenocarcinoma of Small Intestine. Acta
Histochem Cytochem 48(6): 193-204, 2015.
20150458
Maruyama Y, Uehara T, Daikuhara S, Kobayashi Y,
Nakajima T, Matsumoto A, Tanaka E, Ota H : Clinicopathologicalcharacterisation of duodenal adenocarcinoma with high CD44
variant 9 expression. Pathology 47(7): 647-652, 2015.

components may inf luence the incidence of allergictransfusion reactions. Transfusion 55: 2576-2581, 2015.
20150466
Ikegami S, Takahashi J, Kuraishi S, Shimizu M,
Futatsugi T, Uehara M, Shimodaira S, Horiuchi K, Kato H :Efficacy of erythropoietin-beta injections during autologous
blood donation before spinal deformity surgery. Spine 40:
1144-1149, 2015.

Endoscopic Examination Center
20150459
Arai T, Kobayashi A, Yokoyama T, Ohya A,
Fujinaga Y, Shimizu A, Motoyama H,Furusawa N, Sakai
H, Uehara T, Kadoya M, Miyagawa S : Signal intensity ofthe pancreas on magnetic resonance imaging: Prediction of
postoperative pancreatic fistula after a distal pancreatectomy
using a triple-row stapler. Pancreatology 15(4): 380-386,
2015.
20150460
Hanamura T, Ito K, Uehara T, Fukushima
T, Sasaki S, Koizumi T : Chemosensitivity in Carcinoma
Showing Thymus-Like Differentiation: A Case Report andReview of the Literature. Thyroid 25(8): 969-972, 2015.
20150461
Kameda T, Ohkawa R, Yano K, Usami Y,
Miyazaki A, Matsuda K, Kawasaki K, Sugano M, Kubota T,
Tozuka M : Effects of Myeloperoxidase-Induced Oxidation
on Antiatherogenic Functions of High-Density Lipoprotein. J
Lipids 2015: 592594, 2015.
20150462
Umemura T, Joshita S, Sekiguchi T, Usami Y,
Shibata S, Kimura T, Komatsu M, Matsumoto A, Ota M,
Tanaka E : Serum Wisteria floribunda Agglutinin-Positive
Mac-2-Binding Protein Level Predicts Liver Fibrosis andPrognosis in Primary Biliary Cirrhosis. Am J Gastroenterol
110(6): 857-864, 2015.
20150463
Matsuda K, Honda T : High-speed droplet-allelespecific polymerase chain reaction for genotyping of single
nucleotide polymorphisms. Bugert P (ed.) : Molecular Typingof Blood Cell Antigens (Methods Mol Biol 1310). 29-35,
Springer Science+Buisiness Media, New York, 2015.

Blood Transfusion Center
20150464
Kato H, Nakayama T, Uruma M, Okuyama
Y, Handa M, Tomiyama Y, Shimodaira S, Takamoto S : A
retrospective observational study to assess adverse transfusion
reactions of patients with and without prior transfusion history.
Vox Sang 108: 243-250, 2015.
20150465
Kato H, Nakayama T, Uruma M, Okuyama
Y, Handa M, Tomiyama Y, Shimodaira S, Takamoto S :Repeated exposure rather than the total volume of transfused

20150467
Arakura N, Ito T, Tanaka E, Umemura T :Endoscopic Retrograde Cholangiopancreatography using
a multi-bending duodenoscope in patients with a Billroth I
Gastrectomy. Shinshu Med J 63: 385-389, 2015.
20150468
Arakura N, Ito T, Tanaka E, Umemura T :Treatment of a huge pancreatic pseudocyst associatedwith autoimmune pancreatitis. Shinshu Med J 63: 417-418,
2015.
20150469
Oguchi T, Ota M, Ito T, Hamano H, Arakura N,
Katsuyama Y, Meguro A, Kawa S. Muraki T : Investigation ofsusceptibility genes triggering lachrymal/salivary gland lesion
complications in Japanese patients with type 1 autoimmune
pancreatitis. PLoS One 10: e0127078, 2015.
20150470
Furusawa N, Kobayashi A, Yokoyama T, Shimizu
A, Motoyama H, Kanai K, Arakura N, Yamada A, Kitou Y,
Miyagawa S : Biliary tract variations of the left liver withspecial reference to the left medial sectional bile duct in 500
patients. Am J Surg 210: 351-356, 2015.
20150471
Maruyama M, Watanabe T, Kanai K, Oguchi
T, Asano J, Ito T, Muraki T, Hamano H, Arakura N,
Uehara T, Kawa S : Extracorporeal shock wave lithotripsy
treatment of pancreatic stones complicated with advanced
stage autoimmune pancreatitis. BMC Gastroenterol 15: 28,
2015.
20150472
Okamura T, Komatsu M, Ito A, Ito T, Suga T,
Arakura N, Sakai H, Tanaka E : A case of acquired hemophilia
A diagnosed after percutaneous endoscopic gastrostomy. Clin J
Gastroenterol 8: 290-293, 2015.
20150473
Asano J, Watanabe T, Oguchi T, Kanai K,
Maruyama M, Ito T, Muraki T, Hamano H, Arakura N,
Matsumoto A, Kawa S : Association Between Immunoglobulin
G4-related Disease and Malignancy within 12 Years after
Diagnosis: An Analysis after Longterm Followup. J Rheumatol
42: 2135-2142, 2015.
20150474

Nagaya T, Tanaka N, Iwaya Y, Jimbo Y, Tatai T,

31

Ito T, Seki A, Suzawa K, Ochi Y, Hara E, Takata M, Otsuki
T, Iwaya M, Hosaka N, Arakura N, Tanaka E, Hasebe O :Helicobacter pylori-negative Differentiated Adenocarcinomaof the Stomach. Intern Med 54: 2857-2862, 2015.

Medical Informatics

Amano Y, Ehara T, Hamasaki Y, Muramatsu M, Shishido S,
Aikawa A, Hamada R, Ishikura K, Hataya H, Hidaka Y, Noda
S, Koike K, Wakui K, Fukushima Y, Matsumoto N, Awazu M,
Miyake N, Kosho T : Renal complications in 6p duplication
syndrome: microarray-based investigation of the candidate
gene(s) for the development of congenital anomalies of thekidney and urinary tract (CAKUT) and focal segmental
glomerular sclerosis (FSGS). Am J Med Genet A 167A: 592601, 2015.

20150475
Asano J, Watanabe T, Oguchi T, Kanai K,
Maruyama M, Ito T, Muraki T, Hamano H, Arakura N,
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1985
1986
1987
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Y, H o s h i T, Ya n a g i s a w a T, S u g i t a Y : Wa l d e n s t r ö m ' smacroglobulinemia accompanying systemic amyloidosis: theusefulness of endobronchial ultrasound-guided transbronchialneedle aspiration for detecting amyloid deposits. Intern Med 53:
2789-2793, 2014.

20140568N
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5
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20140569N Dombroski BA, Galasko DR, Mata IF, Zabetian CP,
Craig U-K, Garruto RM, Oyanagi K, Schellenberg GD : C9orf72
hexanucleotide repeat expansion and Guam amyotrophic lateralsclerosis-parkinsonism-dementia complex. JAMA Neurol 70:
742-745, 2013.

発

20140570N
発

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63-65

2014

信大
州学
大医
学学
医部
学業
部績
業録
績編
録集
編要
集項
要（
項抜粋）
信州
（平成27年２月28日改正）

１．収録対象 １．収録対象
 信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で認めた施設等に所属する者（当該年に在籍した者全員）認めた施設等に所属する者（当該年度に在籍した者全員）
２．収録内容 ２．収録内容
研究業績を次の３項目に分ける。
研究業績を次の２項目に分ける。
１）論文
１）論文
原著、綜説、展望、症例報告、速報、予報で、査読のある学術雑誌に発表のもの。
原著、綜説、展望、症例報告、速報、予報で学術雑誌に発表のもの。
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をも
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をもち、ち、別刷が発行されているもの）
別刷が発行されているもの）
２）著書
２）著書
単行書、分担執筆。
単行書、分担執筆。
３）その他
治療指針、トピックス、事典等、専門的知見にもとづき執筆された、論文形式の
ただし、以下のものは除外する。
記事（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表に関するもの及び１頁ものの速報は抄録とみなす）
ただし、以下のものは除外する。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表（ハ）業務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）
に関するもの及び１頁ものの速報は抄録とみなす）（ニ）座談会記事。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（ホ）学会記。
（ハ）業and
務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）（ヘ）質疑応答（）、治療指針、問題集の解説、トピックス、話題、グラビア、
（ニ）
座
談会記事。
事典等に類するもの。
（ホ）学会記。
（ト）新聞記事、教育に関する記事、人物紹介、書評、随筆など学術性が認められ（ヘ）論文形式をとらない質疑応答（Q and A）、問題集の解説、話題、グラビア等ないもの。
に類するもの。
（チ）著者表示が団体名で個人の著者性が認められないもの。
（ト）新聞・週刊誌記事、教育に関する記事、人物紹介、書評、随筆など学術性が（ ）学術雑誌とは認められないものに発表したもの。
認められないもの。
（ ） 本及び 論文。
（チ）著者表示が団体名で個人の著者性が認められないもの。
３．収録期間
毎年１月～12月

あ

と

が

き

信州大学医学部医学科
・大学院医学系研究科・医学部附属病院業績録第44号をお届けします。
信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録第8 号をお届けします。
本業績録は過去１年間、各教室や部門などでなされた４つの活動（研究活動、教育活動、診本業績録は過去１年間、各講座や部門等でなされた４つの活動（研究、教育、診療、社会貢献）
療活動、社会貢献）のうち、研究活動の成果として公表された論文を中心にまとめたものです。
のうち、研究活動の成果として公表された論文を中心にまとめたものです。自己点検、自己評
自己点検、自己評価、学内・学外への報告において、本業績録の役割は重要と思われます。この１年の研究活動を振り返り、今後の方向性を考える契機にしていただければ幸いです。
価、学内外への報告において、本業績録の果たす役割は重要と思われます。このような 点から、この１年間の研究活動を振り返り、今後の方向性等を考える契機にしていただけたら幸いに運営費交付金の毎年一定比率削減と重点配分による、中堅大学での研究力の落ち込みが、日じます。
本の論文発表件数の減少、研究競争力の低下につながっていることが指摘されるようになりました（いわゆる豊田レポート）。要するに、研究の裾野を狭めることで、全国に散らばる潜在能力が発揮されにくくなり、コンピテントな研究者の実質的な層が薄くなってしまったという
今年度の 文論文 数は 年度より 減し、 0 年度以 で最も少ない 8 という 果となりことです。そのため、毎年のように日本の受賞者が出るようになったノーベル賞も、最近は喜ました。しかしながら、単なる 数のみの評価がしもであるとは え 、今年度の業
ばれるだけでなく、現場を知る研究者の将来への危惧のコメントがむしろ目立つようになりました。
績の中には めて質の い研究成果も少なくありま。今日、 業生の大学 れや医学科
学定員数増加等により、診療や教育活動等の業務は増加の一 にあります。このような現さて、そのような中堅大学に特に厳しい研究環境の中で、このたびの業績録を見ますと、こではありますが、研究活動は大学が大学であるための大きな 務であり、外部評価 準の重の数年間、一定水準を維持してきていることがわかります。研究者数の減少の中でこのように要項目であることは うまでもありま。今後、各講座・部門等でのさらなる研究の発展を水準が保たれている根底には、現場の先生方それぞれの血のにじむような努力があることが、痛いほどわかります。
祈します。
折しも、2017年度からの科学技術関連予算の十数%の増加が、文科省から打ち出されています。科学の裾野を広げる方向に転換することを祈るばかりです。
最後に、本業績録の編集にあたりご尽力頂きました先生方、図書館職員の方々に厚く御礼申
最後に、本業績録の編集にあたりご尽力頂きました先生方、図書館職員の方々に厚く御礼申し上げます。
し上げます。
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沢村 達也
村
出出 版
版委
委員
員 長：沢村達也
長： 村
出出 版
委 員：鷲塚伸介、瀬戸達一郎、伊東清志
版 委 員：平、 田文 、
知
医学部図書館主査：岩井雅史
医学部図書館主査：

第第 44 号
号
平成
平成 23
29 年１月年１月230日印刷
日印刷
平成
平成 23
29 年１月年１月230日発行
日発行

発行
印刷

3

印刷

2

1881ー4 80

No.44 (2015)

信 州 大 学 医 学 部 医 学 科・大 学 院 医 学 系 研 究 科・医 学 部 附 属 病 院 業 績 録

信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録

第四四号（二〇一五 ）二〇一六

2016