内科学講座消化器内科肝臓分野
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主な論文・著作・業績①Takikawa Y, Endo R, Suzuki K, Tsubouchi H. Early prediction of short-term development of hepatic
encephalopathy in patients with acute liver disease unrelated to paracetamol. A prospective study in Japan. JHepatol 2009;51:1021-1029.
②Takikawa Y, Miyoshi H, Rust C, Roberts P, Siegel R, Mandal PK, Millikan RE, Gores GJ. The Bile Acid Activated
Phosphatidylinositol 3-Kinase Survival Pathway Inhibits Apoptosis Upstream of Bid Translocation to滝川 康裕

内科学講座消化器内科肝臓分野教授

博士(医学)

消化器;病学、肝臓病学、血液凝固学

Mitochondria. Gastroenterology 2001;120:1810-1817.
③Takikawa Y, Endo R, Suzuki K, Fujiwara K, Omata M, The fulminant hepatitis study group of Japan. Predictionof hepatic encephalopathy development in patients with severe acute hepatitis. Dig Dis Sci 2006;51:359-364.
④Takikawa Y, Harada M, Wang T, Suzuki K. The usefulness and accuracy of international normalized ratio (INR)
and activity percent of prothrombin time in patients with liver disease. Hepatol Res 2014,44:92-101.
⑤Takase HM, Itoh T, Ino S, Wang T, Koji T, Akira S, Takikawa Y, Miyajima A. FGF7 is a functional niche signal
required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev 2013;27:169181.
①Miyasaka A, Yoshida Y, Suzuki A, Ueda H, Morino Y, Takikawa Y. A case of suspected portal-pulmonary
hypertension due to hepatitis C virus infection. Clin J Gastroenterol. 2020; 13(1): 90-96.
②Miyasaka A. Yoshida Y, Wang T, Takikawa Y. Next-generation sequencing analysis of the human T-cell and Bcell receptor repertoire diversity before and after hepatitis B vaccination. Hum Vaccin Immunother. 2019; 15(11):2738-2753.

宮坂 昭生

内科学講座消化器内科肝臓分野

消化器内科、准教授

博士(医学) 肝臓病学
ウイルス性肝炎③Miyasaka A, Yoshida Y, Yoshida T, Murakami A, Abe K, Ohuchi K, Kawakami T, Watanebe D, Hoshino T, Sawara
K, Takikawa Y. The Real-world Efficacy and Safety of Ombitasvir/Paritaprevir/Ritonavir for Hepatitis C genotype
1. Intern Med 2018; 57: 2807-2812.
④Sakai A, Noguchi E, Fukushima T, Tagawa M, Iwabuchi A, Kita M, Kakisaka K, Miyasaka A, Takikawa Y,Sumazaki R. Identification of amino acids in antigen-binding site of class II HLA proteins independently
associated with hepatitis B vaccine response.Vaccine. 35(4): 703-710, 2017.
⑤平成27年度科学研究費助成事業（科研費）, 基盤研究（C),研究代表者：宮坂昭生, 研究期間：平成27 〜30年度, B型肝炎ワクチンに対する初期および記憶免疫応答に関する研究内科学講座消化器内科肝臓分野
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主な論文・著作・業績①Kuroda H, Abe T, Kakisaka K, Fujiwara Y, Yoshida Y, Miyasaka A, Ishida K, Ishida H, Sugai T, Takikawa Y.
Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis Cvirus: A novel technique. World J Gastroenterol. 2016;14;22(26):6057-64.
②Kuroda H, Kakisaka K, Oikawa T, Onodera M, Miyamoto Y, Sawara K, Endo R, Suzuki K, Takikawa Y. Liverstiffness measured by acoustic radiation force impulse elastography reflects the severity of liver damage andprognosis in patients with acute liver failure. Hepatol Res. 2015;45(5):571-7.

⿊⽥ 英克

内科学講座消化器内科肝臓分野

特任准教授 博士(医学)

消化器内科学、肝臓病学③Kuroda H, Kakisaka K, Kamiyama N, Oikawa T, Onodera M, Sawara K, Oikawa K, Endo R, Takikawa Y, Suzuki K.
Non-invasive determination of hepatic steatosis by acoustic structure quantification from ultrasound echo
amplitude. World J Gastroenterol. 2012;7;18(29):3889-95.
④Kuroda H, Ushio A, Miyamoto Y, Sawara K, Oikawa K, Kasai K, Endo R, Takikawa Y, Kato A, Suzuki K. Eﬀects ofbranched-chain amino acid-enriched nutrient for patients with hepatocellular carcinoma following
radiofrequency ablation: a one-year prospective trial. J Gastroenterol Hepatol. 2010;25(9):1550-5.
⑤2016年度学術研究助成基⾦助成⾦, 基盤研究(C)，研究代表者:⿊⽥英克, 期間：平成28〜30年度, 研究課題名：超音波画像のテクスチャ解析とエラストグラフィによるNASHの非侵襲的診断法の開発①Kakisaka K, Suzuki Y, Fujiwara Y, Abe T, Yonezawa M, Kuroda H, Ishida K, Sugai, T, Takikawa Y. Evaluation ofballooned hepatocytes as a risk factor for future progression of fibrosis in patients with non-alcoholic fatty liverdisease. J Gastroenterol. 2018 Dec;53(12):1285-1291.
②Kakisaka K, Suzuki Y, Kataoka K, Okada Y, Miyamoto Y, Kuroda H, Takikawa Y. Predictive formula of coma
onset and prothrombin time to distinguish patients who
recover from acute liver injury. J Gastroenterol Hepatol. 2018 Jan;33(1):277-282.
柿坂 啓介

内科学講座消化器内科肝臓分野講師

博士(医学)③Kakisaka K, Kataoka K, Suzuki Y, Kuroda H, Takikawa Y. Appropriate timing to start and optimal response
消化器内科学、肝臓 evaluation of high-dose corticosteroid therapy for patients with acute liver failure. J Gastroenterol. 2017
学

Aug;52(8):977-985.
④Kakisaka K, Cazanave SC, Werneburg NW, Razumilava N, Mertens JC, Bronk SF, Gores GJ. A hedgehog survival
pathway in 'undead' lipotoxic hepatocytes. J Hepatol. 2012 Oct;57(4):844-51.
⑤ Kakisaka K, Cazanave SC, Fingas CD, Guicciardi ME, Bronk SF, Werneburg NW, Mott JL, Gores GJ.
Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. Am J Physiol Gastrointest LiverPhysiol. 2012 Jan 1;302(1):G77-84.

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主な論文・著作・業績①Oikawa T, Shi De Lin, Takikawa Y, Suzuki K: Epidermal Growth factor, dexamethasone and insulin downregulate Per2 mRNA levels and restore circadian oscillation of Per2 mRNA expression in cultured mousehepatocytes / J Iwate Med Assoc Vol.60 NO.4:265-275(2008)②OIKAWA T, KURODA H, TAKIKAWA Y, SUZUKI K
The impact of diabetes and obesity on carcinogenesis in cirrhotic patients with hepatitis C virus infection
JSGE-APAGE Joint Conference 第3回 Asian Paciﬁc Topic Conference③Kasai K, Kooka Y, Suzuki Y, Suzuki A, Oikawa T, Ushio A, Kasai Y, Sawara K, Miyamoto Y, Oikawa K, Takikawa

及川 隆喜

内科学講座消化器内科肝臓分野

消化器内科学、特任講師

博士(医学) 肝臓学、
消化器内視鏡学Y.
Efficacy of Hepatic Arterial Infusion Chemotherapy Using 5-Fluorouracil and Systemic Pegylated Interferon α-2bfor Advanced Intrahepatic Cholangiocarcinoma.
Ann Surg Oncol. 2014 Oct;21(11):3638-45.
④Takayoshi Oikawa, Kei Sawara, Hidekatsu Kuroda, Yasuhiro Takikawa
The effectiveness of cisplatin-eluting beads TACE in the treatment of early/intermediate-stage HCCInternational Liver Cancer Association 10Th Annual Conference Vancouver, Canada September 9–11 2016
⑤Takayoshi Oikawa, Kei Sawara, Hidekatsu Kuroda, Yasuhiro Takikawa
Sorafenib treatment for advanced hepatocellular carcinoma-the effectiveness, safety and controversial point.
The 2017 Gastrointestinal Cancers Symposium SanFrancisco, CA, January 19-21, 2017
①Yoshida Y, Yonezawa M, Okamoto T, Fujiwara Y, Suzuki A, Suzuki Y, Endo K, Kakisaka K, Oikawa T, Kuroda H,Miyasaka A, Takikawa Y: Occurrence of hepatocellular carcinoma 24 years after successful interferon therapy ina patient with chronic hepatitis C: a case report. Clin J Gastroentol 12(2):120-127, 2019
②Yoshida Y, Okada Y, Suzuki A, Kakisaka K, Miyamoto Y, Miyasaka A, Takikawa Y, Nishizawa T, Okamoto H: Fatalacute hepatic failure in a family infected with the hepatitis A virus subgenotype IB: A case report. Medicine 96(吉⽥ 雄一

内科学講座消化器内科肝臓分野助教

博士(医学)

35): e7847, 2017
消化器内科学、肝臓 ③Yoshida Y and Suzuki K. Eﬀects of subcutaneous administration of pegylated interferon alpha-2b on the学

behavior and the cytokine levels of serum and brain in rats. J Iwate Medical Association. 66(3):101-112, 2014.
④吉⽥雄一、滝川康裕：A型・E型肝炎重症化因子とその対策．消化器・肝臓内科 6(1):68-74,2019⑤吉⽥雄一、岡⽥洋平、鈴⽊彰子、宮坂昭生、渡辺太亮、⼤内健、吉⽥俊⺒、⼩野寺美緒、星野孝男、熊⾕一郎、近藤公亮、川上格、石井基嗣、八⽊千栄、三浦達也、滝川康裕：高齢C型慢性肝疾患患者におけるダクラタスビル・ア
スナプレビル併用療法の治療効果と安全性に関する検討．日本高齢消化器病学会誌 19(2):68-74, 2017

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主な論文・著作・業績①Endo K, Kuroda H, Kanazawa J, Sato T, Fujiwara T, Abe T, Sato H, Kooka Y, Oikawa T, Sawara K, Takikawa Y.
Impact of Grip Strength in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib.
Cancers (Basel). 2020;12:E2146②Endo K, Sato T, Suzuki A, Yoshida Y, Kakisaka K, Miyasaka A, Takikawa Y. Sustained virologic response bydirect-acting antivirals suppresses skeletal muscle loss in hepatitis C virus infection. J. Gastroenterol. Hepatol.
2020, doi:10.1111/jgh.14991.

遠藤 啓

内科学講座消化器内科肝臓分野助教

博士(医学)③Endo K, Oikawa T, Kakisaka K, Tamura A, Ehara S, Takikawa Y. The impact of acute portal vein thrombosis on
消化器内科学、肝臓 the prognosis and liver function of cirrhotic patients. Scand J Gastroenterol. 2018:26:1-7.
病学④Endo K, Kuroda H, Oikawa T, Okada Y, Fujiwara Y, Abe T, Sato H, Sawara K, Takikawa Y. Eﬃcacy ofcombination therapy with transcatheter arterial chemoembolization and radiofrequency ablation forintermediate-stage hepatocellular carcinoma. Scand J Gastroenterol. 2018;53:1575-1583.
⑤Endo K, Kakisaka K, Oikawa K, Endo R, Takikawa Y. Comparison of Predicted Energy Expenditure in JapanesePatients with Non-Alcoholic Fatty Liver Disease to Establish a Suitable Nutrition Intervention. J Nutr Sci
Vitaminol. 2016;62:108-15.

①A Lille model for predicting the response of severe alcoholic hepatitis to corticosteroid treatment in Japanesepatients.Suzuki Y, Kakisaka K, Suzuki A, Takahara T, Sasaki T, Sato T, Yonezawa T, Nitta H, Takikawa Y.Hepatol
Res. 2019;49:758-764②Orthotopic liver transplantation for haemophilia A may not always lead to a phenotypic cure of haemophilia A:a case report. Suzuki Y, Kakisaka K, Matsumoto T, Nogami K, Katagiri H, Takahara T, Takikawa Y. Haemophilia.
鈴⽊ 悠地

内科学講座消化器内科肝臓分野

Haemophilia. 2018;24:e420-e422
助教

博士(医学) 肝臓病学、再生医療、分子生物学 ③Liver Regeneration Supported by Muse Cells. Nishizuka SS, Suzuki Y, Katagiri H, Takikawa Y.Adv Exp Med Biol.
2018;1103:219-241.
④Ductular reactions in the liver regeneration process with local inﬂammation after physical partial hepatectomy.
Suzuki Y, Katagiri H, Wang T, Kakisaka K, Kume K, Nishizuka SS, Takikawa Y. Lab Invest. 2016;96:1211-1222.
⑤2020年度科学研究助成事業(科研費)．若手，研究代表者：鈴⽊悠地，研究期間：②020-2022年度，胚盤胞補完法を用いた移植可能な肝臓制作技術の開発

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主な論文・著作・業績①Brain metabolism in minimal hepatic encephalopathy assessed by 3.0-Tesla magnetic resonance spectroscopy.
Kooka Y, Sawara K, Endo R, Kato A, Suzuki K, Takikawa Y.Hepatol Res. 2016 Apr;46(4):269-76. doi:10.1111/hepr.12519. Epub 2015 May 20.PMID: 25847088②Eﬃcacy of hepatic arterial infusion chemotherapy using 5-ﬂuorouracil and systemic pegylated interferon α-2bfor advanced intrahepatic cholangiocarcinoma. Kasai K, Kooka Y, Suzuki Y, Suzuki A, Oikawa T, Ushio A, Kasai Y,Sawara K, Miyamoto Y, Oikawa K, Takikawa Y. Ann Surg Oncol. 2014 Oct;21(11):3638-45. doi: 10.1245/s10434014-3766-7. Epub 2014 May 10.PMID: 24817369③Updating the neuropsychological test system in Japan for the elderly and in a modern touch screen tablet

⼩岡 洋平

内科学講座消化器内科肝臓分野助教

博士(医学) 肝臓病学、肝臓癌IVR治療

society by resetting the cut-off values.Kawaguchi T, Konishi M, Kato A, Kato M, Kooka Y, Sawara K, Endo R,
Torimura T, Suzuki K, Takikawa Y.Hepatol Res. 2017 Nov;47(12):1335-1339. doi: 10.1111/hepr.12864. Epub 2017
Feb 7.PMID: 28066966④Bimodal peaks of liver stiﬀness in a case of drug-induced liver injury.Kakisaka K, Kooka Y, Oikawa T, Suzuki A,Oikawa K, Kuroda H, Kasai K, Takikawa Y.Hepatol Res. 2015 Mar;45(3):343-8. doi: 10.1111/hepr.12341. Epub
2014 Jul 18.PMID: 24720351⑤ソラフェニブ投与における副作用対策としてのテレフォンフォローアップの有用性 ⼩岡 洋平, 永松 洋明, 徳重 貴彦, 森⽥ 俊, 堤 翼, 平井 真吾, 徳安 秀紀, 清水 基規, 立石 秀夫, 鳥村 拓司： The Liver Cancer Journal (1883-9347)8巻
2号 Page146-147(2016.12)① 第14回日本超音波医学会東北地方会奨励賞 平成28年3月
慢性肝疾患の線維化評価における Shear Wave Elastography の有用性 -M2BPGi の比較と複合指 標の検証② 平成28年度 社団法人日本超音波医学会 第6回新人賞受賞 平成29年5月
慢性肝疾患の線維化評価における Shear Wave Elastography の有用性 -M2BPGi の比較と複合指 標の検証③Hidekatsu Kuroda, Tamami Abe, Keisuke Kakisaka, Yudai Fujiwara, Yuichi Yoshida, Akio Miyasaka, Kazuyuki

阿部 珠美

内科学講座消化器内科肝臓分野助教（任期付）

Ishida, Hideaki Ishida, Tamotsu Sugai, and Yasuhiro Takikawa.Visualizing the hepatic vascular architecture using
消化器内科学、肝臓学、超音波医学

superb microvascular imaging in patients with hepatitis C virus: A novel technique. World J Gastroenterol. 2016
Jul 14; 22(26): 6057–6064.
④ Keisuke Kakisaka, Hidekatsu Kuroda, Tamami Abe, Yuji Suzuki, Yuichi Yoshida, Kojiro Kataoka, Yasuhiro
Miyamoto, Kazuyuki Ishida and Yasuhiro Takikawa. Hepatic Hemodynamics and Elevation of Liver Stiffness as
Possible Predictive Markers of Late-onset Hepatic Failure. Intern Med. 2016;55(9):1091-5.

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主な論文・著作・業績① 佐藤 寛毅、⿊⽥ 英克、藤原 裕⼤、阿部 珠美、遠藤 啓、及川 隆喜、佐原 圭、滝川 康裕：超高齢者肝癌に対する佐藤 寛毅

内科学講座消化器内科肝臓分野

ラジオ波焼灼療術の有用性
助教（任期付）

消化器内科学、肝臓学 ② 佐藤 寛毅、滝川 康裕、鈴⽊ 一幸：C型肝炎ウイルス消失後の肝細胞癌の発症リスク