ISSN 1513-7368
Asian Pacific Organization for Cancer Prevention and Control

ASIAN PACIFIC JOURNALOF

CANCER PREVENTIONThe Official Publication of the Asian Pacific Organization forCancer Prevention and the UICC Asia Regional Office for Cancer Control
An Official Journal of the International Association of Cancer Registries

Volume 10,
Number 6, 2009

After Oyagbemi
et al 963

asian cancer control
APOCP Areas
Australasia
Central Asia
China
Japan

Molecular and Dietary Risk Factors?
High fat
Dairy Products
Sugars and Sweets

After Moore
981

High calorie consumption
Insulin Sensitivity

Vegetables

Korea

Fish

Soluble Fiber

Meat

N-3 PUFA's N-6 PUFA's
Receptor Impairment
Obesity

Cereals

Glycemia

High fat
Dairy Products

Insoluble FiberSouth Asia
Sugars and Sweets

South-East Asia
Western Asia

Insulin

Estrogen/
Testosterone

IGF-IR IR

SHRVegetables
Cereals

Soy
Products

Coffee and Tea
Antioxidants

Lipid peroxidation
N-6 PUFA's Meat

Antioxidants
Insoluble Fiber

ImmuneSystem Inflammation

Carcinogens
IGF-I

Water

APJCP

Vitamins/
MetalsFish

INITIATIONGROWTH

DamagePhysical Agentse.g. Hot Food

GENE
GENEACTIVATIONACTIVATIONPRENEOPLASTIC/NEOPLASTIC CELL

DamageN-3 PUFA's

Vitamins/
MetalsPhysical Agentse.g. Hot Food

PUFA's, poly-unsaturated fatty acids; IGF-IR, insulin like growth factor I receptor; IR, insulin
receptor; SHR, steroid hormone receptor;, enhancing stimulus;, inhibitory effect.

Clinical Treatment Education
Epidemiology
Intervention
Palliation
Screening Toxicological Pathology

http://www.apocp.org
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

ASIAN PACIFIC JOURNAL OF CANCER PREVENTIONAPJCP Chief Editor

APOCP Secretary-General

APOCP President

Malcolm A Moore
APJCP Editorial Office,
UICC Asia Regional Office
apocpcontrol@yahoo.com

Keun-Young Yoo
Department of Preventive Medicine,
Seoul National University, Korea
kyyoo@plaza.snu.ac.kr

Murat Tuncer
Department of Cancer Control,
Ministry of Health, Turkey
murat.tuncer@saglik.gov.tr

Subject Editors - Epidemiology

Subject Editors - Toxicological Pathology

Daehee Kang
Seoul National University, Seoul, Korea
dhkang@snu.ac.kr
Alireza Mosavi-Jarrahi
Shahid Beheshti University, Tehran, Iranrmosavi@yahoo.com
Shinkan Tokudome
Nagoya City University, Nagoya, Japan
tokudome@med.nagoya-cu.ac.jp

Sukta Das
Chittaranjan National Cancer Institute, Kolkata, India
suk_tadas@yahoo.com
Young-Joon Surh
Seoul National University, Seoul, Korea
surhyoungjoon@yahoo.co.kr
Hiroyuki Tsuda
Nagoya City University, Nagoya, Japan
htsuda@med.nagoya-cu.ac.jp

Subject Editors - Education/Registration

Subject Editors - Screening and Intervention

Supannee Sriamporn
KhonKaen University, KhonKaen, Thailand
supannee@kku.ac.th
Suraporn Wiangnon (IACR Representative)
Khon Kaen University, Khon Kaen, Thailand
surapon@kku.ac.th
Balkrishna B Yeole
Bombay Cancer Registry, Indian Cancer Society, India
bcrics@vsnl.com

Partha Sarathi Basu
Chittaranjan National Cancer Institute, Kolkata, India
ceds@vsnl.com
Tony Hsui-Hsi Chen
National Taiwan University, Taipei, Taiwan
chenlin@ntw.edu.tw
Hai-Rim Shin
International Agency for Research on Cancer, France
shinhr@iarc.fr

Aims and Scope
The aim of the Asian Pacific Organization for Cancer Prevention and Control is to promote an increased awarenessin all areas of cancer prevention/control and to stimulate research and practical intervention approaches. Its official
journal, the APJCP, is indexed on PubMed and Science Citation Index Expanded. The scope is wide-ranging, including
descriptive, analytical and molecular epidemiology, experimental and clinical histopathology/biology of preneoplasias
and early neoplasias, assessment of risk and beneficial factors, experimental and clinical trials of primary preventive
measures/agents, screening approaches and secondary prevention, clinical epidemiology and all aspects of cancer
prevention education. All of the papers published are freely available as pdf files downloadable from www.apocp.org
or obtainable from the first authors.

International Advisory Board
Yoon-Ok Ahn, Seoul
Gülsün Ozentürk, Izmir
Junshi Chen, Beijing
Yu-Tang Gao, Shanghai
Tadao Kakizoe, Tokyo
Tomoyuki Kitagawa, Tokyo
Adriano Laudico, Manila
Noorwati, Jakarta
Maqsood Siddiqi, Kolkatta
Takashi Sugimura, Tokyo
Kazuo Tajima, Nagoya
Do Duc Van, Hanoi
APJCP Vol 10, No 6

Kunio Aoki, Nagoya
Fahanar Badar, Lahore
Santoso Cornain, Jakarta
P Gangadharan, Kochin
Thiravud Khuhaprema, Bangkok
Hiroshi Kobayashi, Sapporo
MA Mohagheghi, Tehran
Max Parkin, London
Soeripto, Yogyakarta
Young-Joon Surh, Seoul
Suketami Tominaga, Nagoya
Minro Watanabe, Iwate

MAY Ariyaratna, Colombo
Yasmin Bhurgri, Karachi
Somyos Deerasamee, Bangkok
Sagimbek Igisinov, Almaty
Chaudhry Kishore, New Delhi
Arun P Kurkure, Mumbai
Nadeem Nagi, Sana’a
Bhakta Man Shrestha, Chitwan
Petcharin Srivatanakul, Bangkok
Maitree Suttajit, Chiang Mai
Tumubaatar, Ulaanbaatar
Cheng Har Yip, Kuala Lumpur

Asian Pacific Organization for Cancer Prevention and Control

ASIAN PACIFIC JOURNAL

Editorial BoardOF

CANCER PREVENTIONThe Official Publication of the
Asian Pacific Organization for Cancer Prevention and Control
and the UICC-Asian Regional Office for Cancer Control
and an Official Journal of theInternational Association of Cancer Registries
CONTENTS
Volume 10, Number 6, Nov-Dec 2009
MINI-REVIEWS
Curcumin: From Food Spice to Cancer Prevention
Ademola A Oyagbemi et al
.
.
.

.

.

.

963

Cervical Cancer and HPV Vaccines in Developing Countries
Mojgan Karimi Zarchi et al
.
.
.

.

.

969

Toxicology of Engineered Nanomaterials - A Review of Carcinogenic
Potential Hiroyuki Tsuda et al .
.
.
.
.

.

975

Diverse Influences of Dietary Factors on Cancer in Asia
Malcolm A Moore
.
.
.
.

.

981

.

Chronic Disease Prevention Research in Central Asia, the Urals,
Siberia and Mongolia - Past, Present and Future Moore et al

.
.

.

987

RESEARCH COMMUNICATIONS
Hepatitis B Testing and Vaccination in Immigrants Attending English
as a Second Language Classes in British Columbia, Canada
T Gregory Hislop et al
.
.
.
.
.

.

997

Impact of Nutritional Status on the Quality of Life of Advanced Cancer
Patients in Hospice Home Care Negar Shahmoradi et al .
.

.

1003

Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: theSignificance of Expression in Neoplastic Cells within the LymphovascularSpace Jongkolnee Settakorn et al
.
.
.
.
.

1011

Risk Factors for Prostate Cancer in Universiti Kebangsaan Malaysia
Medical Centre: A Case-Control Study Mohd Nizam Subahir et al .

.

1015

Serum Granulocyte Macrophage-Colony Stimulating Factor: a Tumor
Marker in Colorectal Carcinoma? Umut Demirci et al
.
.

.

1021

Changing Trends in Incidence of Ovarian Cancer - the Indian Scenario
Nandagudi Srinivasa Murthy et al
.
.
.
.

.

1025

Punarnavine Induces Apoptosis in B16F-10 Melanoma Cells by
Inhibiting NF-kB Signaling Manu and Kuttan
.
.

.

.

1031

Overview of Chronic Myeloid Leukemia Patients in Pakistan in the
Pre-Imatanib Era Saad Z Usmani et al .
.
.
.

.

1039

Clinical Outcome of the Ovarian Clear Cell Carcinoma Comparedto other Epithelial Ovarian Cancers when Treated with Paclitaxel andCarboplatin Daranee Sirichaisutdhikorn et al
.
.
.

.

1041

Women’s Awareness, Knowledge and Perceived Magnitude Regarding
Common Female Cancers in Yangon, Myanmar
Myo Myo Mon et al
.
.
.
.
.
.

.

1047

Vinorelbine in Combination with Carboplatin followed bySingle-agent Consolidation Therapy for Unresectable Localized orMetastatic Non-small-cell Lung Carcinomas
Suleyman Alici et al
.
.
.
.
.

.

1051

XRCC1399 and hOGG1326 Polymorphisms and Frequencies ofMicronuclei, Comet and Chromosomal Aberrations among Tobacco
Chewers: A South Indian Population Study Sellappa et al .
.

.

1057

Screening of N-ras Gene Mutations in Urothelial Cell Carcinomasof the Urinary Bladder in the Kashmiri Population Pandith et al .

.

1063

Woong Sik Ahn, Seoul
Takayuki Akasu, Tokyo
Hideyuki Akaza, Tsukuba
Suminori Akiba, Kagoshima
Gürbüz Aktas, Izmir
Jamal M Arif, Riyadh
Morteza Atri, Tehran
Micha Barchana, Jerusalem
Chien-Jien Chen, Taipei
Jian-Guo Chen, Qidong
Kexin Chen, Tianjin
Kee-Seng Chia, Singapore
An-Sik Chung, Taejon
Santoso Cornain, Jakarta
Ratchada Cressey, Chiang Mai
Sultan Eser, Izmir
Sunia Foliaki, Tonga
William Foo, Hong Kong
Katsuhiro Fukuda, Kurume
Shoji Fukushima, Osaka
Mark T Goodman, Honolulu
Adele Green, Brisbane
Nobuyuki Hamajima, Nagoya
Tsutomu Hashimoto, Wakayama
Nurbek Igisinov, Astana
Gulnura Igisinov, Almaty
Saginbek Igisinov, Almaty
Gen Iinuma, Tokyo
Masato Ikeda, Kitakyushu
Katsumi Imaida, Kagawa
Manami Inoue, Tokyo
Takafumi Ishida, Tokyo
Hideki Ishikawa, Kobe
Yoshinori Ito, Nagoya
Tetsuya Kamataki, Sapporo
Jeongseon Kim, Goyang
Reiko Kishi, Sapporo
Yoichi Konishi, Nara
Suminori Kono, Fukuoka
Choong Won Lee, Daegu
Won Chul Lee, Seoul
Hiroshi Maeda, Kumamoto
Akihiko Maekawa, Tokyo
Le Bach Mai, Hanoi
Alleyama Mathew, Trivandrum
Parvin Mehdipour, Tehran
Anjum Memon, Kuwait
Masumi Minowa, Tokyo
Masanao Miwa, Tsukuba
Mitsuru Mori, Sapporo
Hideki Mori, Gifu
Masaki Nagai, Saitama
Kei Nakachi, Hiroshima
Dai Nakae, Tokyo
Hitoshi Nakagama, Tokyo
Masakazu Nakamura, Osaka
Hoyoku Nishino, Kyoto
LeTran Ngoan, Hanoi
Filiz Ogce, Izmir
Hiroko Ohgaki, Lyon
Hajime Ohigashi, Kyoto
Hiroshi Ohshima, Shizuoka
Yoshiyuki Ohno, Nagoya

APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control
Estrogen Receptor, Progesterone Receptor, HER2/neu, P53 and Ki-67
status of Male Breast Carcinomas in Pakistan Jamal et al
.

.

1067

Neoplasia/dysplasia Surveillance of Oral Lichen Planus in
Malaysia: a Preliminary Study using Topography Maps Lim et al .

.

1071

Eight Year Survival among Breast Cancer Malaysian Women from
University Kebangsaan Malaysia Medical Centre Al-Naggar et al .

.

1075

Breast Carcinoma in Young Women Aged 30 or Less in Northern Pakistan- the Armed Forces Inst. of Pathology Experience Mamoon et al .
.

1079

Complementary and Alternative Medicine in Cancer Patients Analysis of Influencing Factors in Turkey Malak et al
.

.

.

1083

Anti-tumor Activity of Phyllanthus niruri (a Medicinal Plant) on
Chemical-induced Skin Carcinogenesis in Mice Sharma et al
.

.

1089

Screening and Perceived Severity of Cervical Cancer among Women
Attending Mahalapye District Hospital, Botswana Hoque et al
.

.

1095

Perspectives on Strategies for Establishing Cancer on the Global Health
Agenda: Possibilities of Creating Infrastructure for Prevention
Information using School Health Classes Norie Kawahara

.

1101

Sida rhombifolia ssp. retusa Seed Extract Inhibits DEN Induced
Murine Hepatic Preneoplasia and Carbon Tetrachloride
Hepatotoxicity Radhika Poojari et al
.
.

.

1107

Impact of a Health Education Intervention Program Regarding
Breast Self Examination by Women in a Semi-Urban Area of Madhya
Pradesh, India Sanjeev K Gupta et al
.
.
.
.

.

.

1113

Clinical Evaluation of Parapelvic Renal Cysts: Do These Represent
Latent Urological Malignant Disease? Yukihiro Umemoto et al
.

.

1119

Histopathological Patterns of Female Breast Lesions at a Secondary
Level Care in Saudi Arabia Tarek Tawfik Amin et al
.

.

1121

Influence of Matrix Metalloproteinase Gene Polymorphisms in
Healthy North Indians Compared to Variations in other Ethnic
Groups Worldwide Priyanka Srivastava et al
.
.

.

1127

.

1131

.

1137

.

.

1141

Weekly Paclitaxel/ Docetaxel Combined with a Platinum in theTreatment of Advanced Non-Small Cell Lung Cancer: a Study on
Efficacy, Safety and Pre-medication Jian-Nong Zhou et al .
.

.

Oral Cancer Presentation Among Malay Patients in Hospital
Universiti Sains Malaysia, Kelantan Asmani Abdul Razak et al.
.
Induction of Apoptosis in the Human Leukemic U937 Cell Line by
Kaempferia parviflora Wall.ex.Baker Extract and Effects of
Paclitaxel and Camptothecin Ratana Banjerdpongchai et al
Chemoprevention of 1,2-Dimethylhydrazine-Induced Colon
Carcinogenesis by a Non-Steroidal Anti-Inflammatory Drug,
Etoricoxib, in Rats: Inhibition of Nuclear Factor kB
Lalita Tanwar et al
.
.
.
.
.

.

1147

Pre-treatment Hemoglobin Levels are Important for Bladder Carcinoma
Patients with Extravesical Extension undergoing Definitive Radiotherapy
Vuslat Yurut-Caloglu et al
.
.
.
.
.
.

1151

Histopathological Findings for Cervical Lesions in Malaysian Women
Al-Jashamy Karim et al
.
.
.
.
.

.

1159

Colorectal Cancer Patients in a Tertiary Referral Centre in Malaysia: a Five
Year Follow-up Review Mohd Radzniwan A Rashid et al .
.
.

1163

Prevalence of Tobacco Use and Tobacco-dependent Cancers in Males in the
Rural Cancer Registry Population at Barshi, India Ranjit V Thorat et al.

1167

Significance of Alanine Aminotransferase Testing in Diagnosis of Acute andChronic HBV Infection Ajay Kumar et al
.
.
.
.

1171

Identification of a Hepatitis B Virus Core Promoter Mutant by PCR- RFLP
in Patients Suffering from Chronic Liver Disease, Uttar Pradesh, India
Ajay Kumar et al
.
.
.
.
.
.
.

1173

Naoyuki Okamoto, Kanagawa
Toshihiko Osawa, Nagoya
Semih Ötles, Izmir
Ozgur Ozyilkan, Ankara
Kwang-Kyun Park, Seoul
Nguyen M Quoc, Ho Chi Minh CityR Rajkumar, Ambillikai
T Rajkumar, Chennai
Hiroshi Saito, Tokyo
Toshiyuki Sakai, Kyoto
Luming Shi, Singapore
Hai Rim Shin, Seoul
Tomoyuki Shirai, Nagoya
Hutcha Sripling, Songklaa
Songphol Srisukho, Chiang Mai
Toshiro Takezaki, Kagoshima
Takuji Tanaka, Kanazawa
Masae Tatematsu, Nagoya
Witaya Thamavit, Bangkok
Danai Tiwawech, Bangkok
Eiju Tsuchiya, Saitama
Ichiro Tsuji, Sendai
Hideaki Tsukuma, Osaka
Soo Jong Um, Seoul
Gajalakshmi Vendhan, Chennai
Keiji Wakabayashi, Tokyo
Hiroshi Watanabe, Kyoto
Hiromitsu Watanabe, Hiroshima
Yoshiyuki Watanabe, Kyoto
Viroj Wiwanitkit, Bangkok
Sopit Wongkham, Khon Kaen
Zentaro Yamagata, Yamanashi
Naohito Yamaguchi, Tokyo
Kenji Yamao, Nagoya
Takesumi Yoshimura, Kitakyushu
Shun-Zhang Yu, Shanghai
Yasuhito Yuasa, Tokyo

This pdf file is supplied free ofcharge by the Asian PacificOrganization for Cancer Prevention
and Control, in cooperation with the
UICC-Asian Regional Office forCancer Control and Asian Pacific
Press, Ltd.

Lack of Effects of Single Nucleotide Polymorphisms of the DNA Methyltransferase
1 Gene on Gastric Cancer in Iranian Patients Khatami et al.
.
1177
Effects of Amino Acid Substitution Polymorphisms of two DNA Methyltransferases on Susceptibility to Sporadic Colorectal Cancer Khatami et al .

1183

COMMENTARIESColostomy Irrigation: An Important Issue for Muslim Individuals
Karadag and Baykara
.
.
.
.
.
.

.

1189

Proposal for a Cooperative Study on Population-based Cancer Survival in
Selected Registries in East Asia Hideo Tanaka et al
.
.
.

1191

APJCP Vol 10, No 6P
AE

Asian Pacific Organization for Cancer Prevention and Control

Curcumin: From Food Spice to Cancer Prevention Ademola A
Oyagbemi, Adebowale B Saba, Azeez O Ibraheem (ademolaoyagbemi@yahoo.com)
Mini-Abstract
Curcumin is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder.
It is known to have anti-inflammatory, anti-oxidant, and anticarcinogenic potential. It is a potent inhibitor of
cytochrome P450 with capacity to simultaneously induce detoxifying enzymes such as glutathione S-transferase.
Curcumin is a potent inhibitor of cyclooxygenase-2, lipooxygenase, ornithine decarboxylase (ODC), nuclear
factor-kB, c-Jun N-terminal kinase and protein kinase C and may play a vital role against pathological conditions
such as cancer, atherosclerosis, and neurodegenerative diseases. Asian Pacific J Cancer Prev, 10, 963-967

Cervical Cancer and HPV Vaccines in Developing Countries
Mojgan Karimi Zarchi, Nadereh Behtash, Zohreh Chiti, Saeed Kargar(drkarimi2001@yahoo.com)

Mini-Abstract
Prevention of HPV infection is the main purpose of cervical cancer prevention and vaccination is expected
to reduce up to 70% of related cervical cancer and prevent precancerous and cancerous lesions of the genitalia.
However, screening programs are still essential for those who have already been exposed to the high risk formsof the virus and educational and information programs continue to play important roles to increase the successrate of screening, by whichever of the modalities is most appropriate for the local conditions
Asian Pacific J Cancer Prev, 10, 969-974

Toxicology of Engineered Nanomaterials - A Review ofCarcinogenic Potential Hiroyuki Tsuda, Jiegou Xu, Yuta Sakai,
Mitsuru Futakuchi, Katsumi Fukamachi (htsuda@med.nagoya-cu.ac.jp)
Mini-Abstract
An overview of currently available carcinogenicity risk evaluation results of nanotechnology materials raises
serious questions as to their safety. NP sized titanium dioxide (nTiO2) and carbon black (nCB) are carcinogenic
to the lung of female rats, and the tumors preferentially include squamous cell morphology. Carbon nanotubes(CNT) induce mesotheliomas when applied intraperitoneally in rats and mice. Data for Fullerenes are insufficientto evaluate carcinogenic risk. Sub-chronic toxicity data indicate that, in general, NPs form aggregates andagglomerates and cause foreign body reactions at their applied sites with inflammatory cell, including macrophage,
infiltration. These findings are similar to the biological effects of asbestos, a potent carcinogen, and indicate that
careful assessment of NPs is indispensable.
Asian Pacific J Cancer Prev, 10, 975-980

Diverse Influences of Dietary Factors on Cancer in Asia
Malcolm A Moore (apocpcontrol@yahoo.com)
Mini-Abstract
What we eat or do not eat is exceedingly important in determining what cancers or other chronic disease we
may suffer from.Carcinogens may be integral contaminants of the diet, like nitrosamines in some situations andaflatoxins. Examples of co-carcinogenic agents may include grit in bread products, salt in pickles or betel inchewing quids. Dietary insufficiencies, for example of zinc, may also act to increase sensitivity to genetic damage.
In addition we have dietary fibre which can decrease carcinogen exposure through accelerating passage of
faeces through the gut. Natural anti-inflammatory agents like N-3 fatty acids in fish offer another example ofpreventive factors in the diet. Individual dietary components, like isoflavones in soy products, can interfere withhormone function to exert a beneficial action.
Asian Pacific J Cancer Prev, 10, 981-986
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

Chronic Disease Prevention Research in Central Asia, theUrals, Siberia and Mongolia - Past, Present and Future
Malcolm A Moore, Gulmira Aitmurzaeva, Zhetkergen A Arsykulov, Maratbek
Bozgunchiev, Saule Alkeeva Dikanbayeva, Gulnara Igisinov, Nurbek Igisinov,
Saginbek Igisinov, Sholpan Karzhaubayeva, Dondov Oyunchimeg, Trendsuren
Oyunsuren, Mashhura Soipova, Tumubaatar(apocp2000@yahoo.com)
Mini-Abstract
Central Asia, the Urals, Siberia and Mongolia cover an immense section of Asia and although relatively
sparsely populated the total inhabitants number well in excess of 100 million. Here we focus on published workfrom the individual countries, as assessed by PubMed searches using the country name with cancer, cardiovascular,
metabolic syndrome and diabetes as search terms, with an especial focus on epidemiology, environmental
carcinogenicity and screening.
Asian Pacific J Cancer Prev, 10, 987-996

Hepatitis B Testing and Vaccination in Immigrants Attending
English as a Second Language Classes in British Columbia,
Canada T Gregory Hislop, Chris D Bajdik, Chong Teh, Wendy Lam, ShinPing Tu, Yutaka Yasui, Roshan Bastani, Vicky M Taylor (cbajdik@bccrc.ca)
Mini-Abstract
Health care practitioners need to be cognizant of HBV testing, and possibly vaccination, in some of theirpatients, including immigrants from countries with endemic HBV infection. Infected persons need to be identified
by blood testing in order receive necessary care to prevent or delay the onset of liver disease as well as to adopt
appropriate behaviours to reduce the risk of transmission to others. Close contacts of infected persons also
require HBV testing and subsequent vaccination (if not infected) or medical management (if infected)
Asian Pacific J Cancer Prev, 10, 997-1002

Impact of Nutritional Status on the Quality of Life of Advanced
Cancer Patients in Hospice Home Care Negar Shahmoradi, Mirnalini
Mini-Abstract

Kandiah, Loh Su Peng (mirna@medic.upm.edu.my)

This cross-sectional study examined the association between global quality of life and its various subscaleswith nutritional status among 61 (33 females and 28 males) advanced cancer patients cared for by selected
hospices in peninsular Malaysia. The findings suggest that there is a need for a comprehensive nutritional
intervention for improving nutritional status and quality of life in terminally ill cancer patients under hospicecare.
Asian Pacific J Cancer Prev, 10, 1003-1010

Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: the Significance of Expression in Neoplastic Cells
within the Lymphovascular Space Jongkolnee Settakorn, Surapan
Khunamornpong, Kornkanok Sukpan, Jatupol Srisomboon, Sumalee
Siriaungkul (skhunamo@med.cmu.ac.th)
Mini-Abstract
In this study, we evaluated whether COX-2 expression of neoplastic cells within lymphovascular spaces(tumor emboli) would provide additional prognostic information. Expression of COX-2 in tumor emboli (LVCOX-2 expression) was identified in 61 cases (40.7%). LV-COX-2 expression was associated with high LVSI
count (p<0.001) and had a marginal association with tumor COX-2 expression (p=0.050) and lymph nodemetastasis (p=0.063). Evaluation of COX-2 expression in tumor emboli may provide additional prognostic value
for lymph node metastasis in cervical squamous cell carcinomas. Asian Pacific J Cancer Prev, 10, 1011-1014
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

Risk Factors for Prostate Cancer in Universiti Kebangsaan
Malaysia Medical Centre: A Case-Control Study✄✄✄✄Mohd Nizam
Subahir, Shamsul Azhar Shah, Zulkifli Md Zainuddin(shamsulazharshah@yahoo.com)

Mini-Abstract
A study was conducted in Malaysia to recognize the risk factors for prostate cancer patients who came fortreatment at Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Most of the cases were above 70
years old. The majority were Chinese (50.0%) followed by Malay (46.4%) and Indian (3.6%). Multivariate
analysis showed cases were more likely to have a first-degree relative with a history of cancer, to have been
exposed to pesticides and consumed more meat. Significantly reduced risks of prostate cancer were notedamong those consuming more vegetables, more tomatoes and those who had frequent sexual intercourse.
Asian Pacific J Cancer Prev, 10, 1015-1020

Serum Granulocyte Macrophage-Colony Stimulating Factor:a Tumor Marker in Colorectal Carcinoma? Umut Demirci, Ugur
Coskun, Banu Sancak, Banu Ozturk, Burak Bahar, Mustafa Benekli, Suleyman
Buyukberber ( ugurcos@hotmail.com)
Mini-Abstract

The aim of the present study was to determine the effect of granulocyte macrophage colony-stimulating
factor and carcinoembryogenic antigen levels in predicting survival. Plasma levels of GM-CSF were measured
in 51 patients with previously untreated colorectal cancer patients and 21 healthy adults as normal controls. We
found significantly elevated GM-CSF but the results suggested that serum GM-CSF may not be useful forclinical information in prognosis as a tumor marker in colorectal cancer.
Asian Pacific J Cancer Prev, 10, 1021-1024

Changing Trends in Incidence of Ovarian Cancer - the Indian
Scenario Nandagudi Srinivasa Murthy, S Shalini, G Suman, Srekantaiah
Pruthvish, Aleyamma Mathew (nsmurthy44@yahoo.com)
Mini-Abstract
The present communication reports the trends in the incidence rate of ovarian cancer for Indian women.
During the period 2001-06, the age-standardized incidence rates (ASR) for ovarian cancer varied from 0.9 to 8.4
per 100,000 person years amongst various registries. The highest incidence was noted in Pune &Delhi registries.
The Age Specific Incidence Rate (ASIR) for ovarian cancer revealed that the disease increases from 35 years ofage and reaches a peak between the ages 55-64. The trend analysis by period showed an increasing trend in theincidence rate of ovarian cancer in most of the registries, with a mean annual percentage increase in ASR
ranged from 0.7% to 2.4 %.
Asian Pacific J Cancer Prev, 10, 1025-1030

Punarnavine Induces Apoptosis in B16F-10 Melanoma Cells
by Inhibiting NF-kB Signaling
Kanjoormana Aryan Manu, Girija Kuttan (amalacancerresearch@gmail.com)
Mini-Abstract
The objective of this study was to assess the effect of Punarnavine, an alkaloid isolated from Boerhaavia
diffusa, on apoptosis in B16F-10 melanoma cells. Treatment of B16F-10 melanoma cells with nontoxic
concentrations of Punarnvine resulted in the presence of apoptotic bodies and DNA fragmentation in a dose
dependent manner. All the results demonstrate that Punarnavine induces apoptosis via activation of p53 induced
caspase-3 mediated pro-apoptotic signaling and suppression of NF-kB induced Bcl-2 mediated survival signaling.
Asian Pacific J Cancer Prev, 10, 1031-1037
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

Overview of Chronic Myeloid Leukemia Patients in Pakistan
in the Pre-Imatanib Era
Saad Z Usmani, Shakeeb A Yunus,
Mini-Abstract

Yasser Jamal(saadzu@yahoo.com)

The objective was to study the patient characteristics of patients diagnosed with chronic myelogenous leukemia(CML) at a tertiary care cancer hospital in Pakistan.A total of 461 CML patient charts were reviewed. The mean
and median ages at presentation were much younger than in the prior reports in the western literature with aquicker progression of disease. Tyrosine kinase inhibitors will likely have more impact on the lifespan of CML
patients in Pakistan due to younger age at diagnosis.
Asian Pacific J Cancer Prev, 10, 1039-1040

Clinical Outcome of the Ovarian Clear Cell Carcinoma
Compared to other Epithelial Ovarian Cancers when Treatedwith Paclitaxel and Carboplatin Daranee Sirichaisutdhikorn,
Prapaporn Suprasert, Surapan Khunamornpong (psuprase@mail.med.cmu.ac.th)
Mini-Abstract
Our aim was to evaluate the progression free survival (PFS) of ovarian clear cell carcinoma (OCCC) patientscompared to other epithelial histology patients when treated with surgery followed by carboplatin and paclitaxel(PT) regimen. Patients were commonly younger and presented in earlier stages than non-clear cell ovariancancer patients.In early stages, clear cell ovarian cancer patients had similar outcomes to other epithelial ovarian
histology patients, whereas the outcome was very poor in advanced stages.
Asian Pacific J Cancer Prev, 10, 1041-1045

Women’s Awareness, Knowledge and Perceived Magnitude
Regarding Common Female Cancers in Yangon, Myanmar
Mini-Abstract

Myo Myo Mon, Mon Mon, Kyu Kyu Than (mmyomon@gmail.com)

A community-based, cross-sectional study was conducted with the objectives of assessing the women’sawareness and knowledge on common female cancers and estimating the perceived magnitude and survival ofcancer breast and cervix. Almost all of them said that both diseases can be cured at early stage. Cancer breast, uterus
and cervix were mentioned as the most common female cancers according to their perceived magnitude. Althoughcervical and breast cancer were perceived as common female cancers, health education activities regarding risk factors
and early warning signs of these cancer still need to be promoted.
Asian Pacific J Cancer Prev, 10, 1047-1050

Vinorelbine in Combination with Carboplatin followed bySingle-agent Consolidation Therapy for Unresectable Localized
or Metastatic Non-small-cell Lung Carcinomas Suleyman Alici,
Ugur Coskun, Necati Alkis, Alper Sevinc, Faysal Dane, Mahmut Gumus, Metin
Ozkan, Ali Osman Kaya, Gokhan Celenkoglu, Suleyman Buyukberber, Mustafa
Altunbas, Mustafa Benekli; for the Anatolian Society of Medical Oncology
Mini-Abstract(suleymanalici@yahoo.com)

Despite the low dose of vinorelbine (25mg/m2 i.v. on day 1 and only 60 mg/m2 oral on day 8, every 3 weeks)achieved during the study, the response rate of 34.7%, the disease control of 70.8% and the 10 months medianoverall survival with tolerable toxicity profile, confirmed that this combination, offers an active and safe regimen
for patients with advanced non-small-cell lung cancer.
Asian Pacific J Cancer Prev, 10, 1051-1055
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

XRCC1399 and hOGG1326 Polymorphisms and Frequenciesof Micronuclei, Comet and Chromosomal Aberrations amongTobacco Chewers: A South Indian Population Study Sudha
Sellappa, Shibily Prathyumnan, Shyn Joseph, Kripa S Keyan, Mythili
Balakrishnan, K Sasikala ( sudhasellappa@yahoo.co.in)
Mini-Abstract
In the present study, we explored the relationship between polymorphisms in the DNA repair gene XRCC1399
and hOGG1326 genotypes using polymerase chain reaction-restriction fragment length polymorphism and riskof cancer development. 156 smokeless tobacco users and 70 controls without significant exposure to mutagens
were recruited. There were significant differences in the micronucleus (MN), Comet scores and chromosomal
aberrations (CA) between smokeless tobacco users and control subjects by Student’s t-test (P<0.05). Thesefindings provide evidence for the view that polymorphisms in DNA repair genes may modify individual
susceptibility to tobacco related cancers
Asian Pacific J Cancer Prev,10, 1057-1062

Screening of N-ras Gene Mutations in Urothelial Cell
Carcinomas of the Urinary Bladder in the Kashmiri Population
Arshad A Pandith, Zaffar A Shah, Nighat P Khan, Adfar Y Bhat, Saleem M
Wani, Mushtaq A Siddiqi (arshaajiz@gmail.com)
Mini-Abstract
The objective of this study was to assess the frequency of specific-point mutations in N-ras of the RAS genefamily in a group of Kashmiri patients with bladder cancer and to observe any association with clinicopathologicalparameters. Although N-ras gene mutation might be one of the mechanisms underlying oncogenesis of urothelial
cancer, it seems to be a relatively rare event in Kasmiris.
Asian Pacific J Cancer Prev, 10, 1063-1066

Estrogen Receptor, Progesterone Receptor, HER2/neu, P53 andKi-67 status of Male Breast Carcinomas in Pakistan Shahid
Mini-Abstract

Jamal*, Huma Mushtaq, Azhar Mubarik, Tariq Masood
Malik (sjarjawj@yahoo.com)

The aim of present study was to assess the status of estrogen and progesterone receptors, HER2/neu, p53 andki-67 in male breast carcinomas in our institute. The majority of the cases were above 65 years of age.
Histologically, the invasive ductal carcinoma was the predominant lesion.The majority of male breast carcinomas
in Pakistan are ER and PR positive and demonstrate immunoreactions for prognostic markers. The results
point to a relatively aggressive nature of such lesions.
Asian Pacific J Cancer Prev, 10, 1067-1070

Neoplasia/dysplasia Surveillance of Oral Lichen Planus in
Malaysia: a Preliminary Study using Topography Maps
Jimie Siew Mei Lim, Sum Pei Tang, Chong Huat Siar (chsiar@gmail.com)
Mini-Abstract
To evaluate the association between clinico-pathological features and HER2 overexpression in breast cancer.
, a retrospective study conducted in the Department of Surgery, University Malaya Medical Centre.HER2
overexpression was observed in 30.3% of Malaysian female breast cancer patients. This group of patients
represents a more aggressive subtype of breast cancer with higher tumour grade, PR negativity andlymphovascular positivity. No significant relationship was established between HER2 overexpression and age,
race, lymph node, ER, pathology subtype and stage of disease.
Asian Pacific J Cancer Prev, 10, 1071-1074
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Asian Pacific Organization for Cancer Prevention and Control

Eight Year Survival among Breast Cancer Malaysian Womenfrom University Kebangsaan Malaysia Medical Centre
Redhwan Ahmed Mohammed Al-Naggar, Zaleha Md Isa, Shamsul Azhar Shah,Md Idris Mohd Nor, Robert Chen, Fuad Ismail, Sami Abdo Radman Al-Dubai(zms@ppukm.ukm.my

Mini-Abstract
A retrospective study of 472 Malaysian women with breast cancer from the Medical Record Department atUniversiti Kebangsaan Malaysia Medical Centre (UKMMC) was performed with survival analysis carried out
using the Kaplan-Meier with log-rank test for univariate analysis and Cox-regression for multivariate analysis.
Being Chinese and having a family history of cancer are predictors of longer survival among the Malaysianbreast cancer women
Asian Pacific J Cancer Prev, 10, 1075-1078

Breast Carcinoma in Young Women Aged 30 or Less inNorthern Pakistan - the Armed Forces Institute of Pathology
Experience
Nadira Mamoon, Usman Hassan*, Sajid Mushtaq(usman_hassan256@hotmail.com)

Mini-Abstract
The study was carried out to document the occurrence of early onset breast cancer in our population and toassess prognostic variables. Most frequent age group was 26-30 years (78.6%). The most common histologicaltumour type was invasive ductal carcinoma (88.7%), followed by invasive lobular carcinoma (5.4%).Grade 2(57.1%), followed by grade 3 (29.8%) were the most frequent. Out of 68 cases in which lymph nodes were
included, lymph node metastasis was seen in 55(80.8%). Breast cancer is much commoner in young women in
Pakistan as compared to the rest of the world.
Asian Pacific J Cancer Prev, 10, 1079-1082

Complementary and Alternative Medicine in Cancer Patients- Analysis of Influencing Factors in Turkey Arzu Tuna Malak,Özgül Karayurt, Emel Demir, Aylin Sami Yümer (arzutunamalak@gmail.com)
Mini-Abstract
This cross-sectional and descriptive study analysed complementary and alternative medicine (CAM) practicesof patients with cancer diagnoses and influencing factors.Alternative treatments apply herbal treatments
concomitantly such as honey, garlic; balsam apple, iscum album, tar oil and 29.1% of them only use stinging
nettle. As a complementary treatment; 60% of patients pray for healing and 16.4% of them have massage
regularly. The cancer patients in the study who live in Çanakkale province and in its districts use CAM. CAM
practice does not vary by selected sociodemographic characteristics and the hope level.
Asian Pacific J Cancer Prev, 10, 1083-1087

Anti-tumor Activity of Phyllanthus niruri (a Medicinal Plant)
on Chemical-induced Skin Carcinogenesis in Mice Priyanka
Sharma, Jyoti Parmar, Preeti Verma, Priyanka Sharma, PK Goyal
Mini-Abstract(pkgoyal2002@rediffmail.com)

Phyllanthus niruri is a well known medicinal plant which has been used in Ayurvedic medicine ashepatoprotective, antiviral, antibacterial, analgesic, antispasmodic and antidiabetic. The present study was carriedout to evaluate the anti-tumor activity of a hydro-alcoholic extract of the whole plant, in 7-9 week old male Swiss
albino mice, on the two stage process of skin carcinogenesis induced by a single topical application of 7, 12dimethylbenz (a)anthracene. The results thus suggest that P. niruri extract exhibits significant anti-tumor activity,
which supports the traditional medicinal utilization of this plant. Asian Pacific J Cancer Prev, 10, 1089-1094
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

Screening and Perceived Severity of Cervical Cancer among
Women Attending Mahalapye District Hospital, Botswana
Muhammad Hoque, C M Ibekwe, Busi Ntuli-Ngcobo
Mini-Abstract(Muhammad_Hoque@embanet.com)

The objectives of the study were to describe women’s perceived severity to cervical cancer and its associations
with socio-demographic characteristics. Most of the women were sure about the severity of cancer as they
responded mostly agreeing or strongly agreeing with statements about severity of cervical cancer.It was foundthat the screening rate is still far too low compared to the national target of greater than 75%. Therefore, despite
awareness of the perceived severity of cervical cancer, the reasons why at risk women fail to participate incervical cancer screening need to be adequately explored.
Asian Pacific J Cancer Prev, 10, 1095-1100

Perspectives on Strategies for Establishing Cancer on the
Global Health Agenda: Possibilities of Creating Infrastructure
for Cancer Prevention Information using School Health Classes
Mini-Abstract

Norie Kawahara(noriekawahara@nifty.com)

As a joint China-Japan research project, in China a questionnaire survey has been implemented throughschool pupils, with pupils and parents being asked about health classes implemented in schools. From theperspective of formulating strategy for establishing cancer on the global health agenda we will use the data
gained from the surveys to analyze and examine the possibilities and significance of creating an infrastructure
for a multilateral information network about cancer prevention.. Asian Pacific J Cancer Prev, 10, 1101-1106

Sida rhombifolia ssp. retusa Seed Extract Inhibits DEN
Induced Murine Hepatic Preneoplasia and Carbon
Tetrachloride Hepatotoxicity Radhika Poojari, Sanjay Gupta, Girish
Maru, Bharat Khade, Sanjay Bhagwat (drradhikapoojari@gmail.com)
Mini-Abstract
Inhibitory effects of S. rhombifolia ssp. retusa seed extract on DEN induced hepatocellular preneoplastic
foci and carbon tetrachloride (CCl4) induced hepatotoxicity were investigated in rats. Histopathological andtransmission electron microscopic studies showed prevention of cellular degenerative changes. Depleted
glutathione, protein and albumin levels were restored.The chemopreventive and hepatoprotective potentials of
seed extract appear due to free radical scavenging activity and restoration of cellular structural integrity.
Asian Pacific J Cancer Prev, 10, 1107-1112

Impact of a Health Education Intervention Program Regarding
Breast Self Examination by Women in a Semi-Urban Area of
Madhya Pradesh, India Sanjeev K Gupta, DK Pal, R Garg, R Tiwari,
Mini-Abstract

AK Shrivastava, M Bansal (drsanjeev15@gmail.com)

The present study aimed to assess the impact of a health education intervention program about breast self
examination (BSE) among women in a semi-urban area in Madhya Pradesh, India.An overall increase in theawareness of 43% and 53% of BSE practice was observed in the study group after intervention. Seven cases ofbreast disease were detected The knowledge and practices of women toward breast self examination for early
detection were observed to be inadequate in respondents but there was a significant improvement after theintervention.
Asian Pacific J Cancer Prev, 10, 1113-1117
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

Clinical Evaluation of Parapelvic Renal Cysts: Do These
Represent Latent Urological Malignant Disease? Yukihiro
Umemoto, Takehiko Okamura, Hidetoshi Akita, Takahiro Yasui,
Kenjiro Kohri (hiko2546@sf.commufa.jp)
Mini-Abstract
We here examined all parapelvic renal cyst patients who consulted our Department between April 1998 andDecember 2004 with the focus on potential for malignant development. Unless a parapelvic renal cyst causes
pyelonephritis, symptomatic renal stones, or back discomfort, treatment is not indicated. However, the possibility
that urological malignant disease may be encountered should be borne in mind and appropriate diagnostic
measures should be performed. Furthermore, careful follow up of parapelvic renal cyst patients may be required.
Asian Pacific J Cancer Prev, 10, 1119-1120

Histopathological Patterns of Female Breast Lesions at a
Secondary Level Care in Saudi Arabia Tarek Tawfik Amin,
Abdul Rahman Saleh Al-Mulhim, Rajan Chopra (dramin55@gmail.com)
Mini-Abstract
The objective of this study was to characterize the histopathological patterns of female breast lesions
encountered at a secondary level care centre in Al Hassa, Saudi Arabia, with special emphasis on multiplicity ofbenign lesions, their proliferative nature and level of risk for progression. Benign breast lesion multiplicity isfrequent among Saudi female patients; with or without atypia these lesions represent a sizable risk of potential
progression to breast cancer. Meticulous follow up with frequent screening may be useful for prevention.
Asian Pacific J Cancer Prev, 10, 1121-1126

Influence of Matrix Metalloproteinase Gene Polymorphisms
in Healthy North Indians Compared to Variations in other
Ethnic Groups Worldwide Priyanka Srivastava, Rakesh Kapoor,
Rama Devi Mittal (ramamittal@yahoo.com)
Mini-Abstract
Several polymorphisms in matrix metalloproteinases have been implicated in the development of cancer aswell as other diseases. Since their frequency distributions in the general North Indian population is not known
the present study was conducted with the focus on MMP-1(-519) A>G, MMP-1(-1607) 1G>2G, and MMP-7(181) A>G gene polymorphisms. Our results suggest that frequency in these MMP genes exhibit distinctive
patterns in India that could perhaps be attributed to ethnic variation.
Asian Pacific J Cancer Prev, 10, 1127-1130

Oral Cancer Presentation Among Malay Patients in Hospital
Universiti Sains Malaysia, Kelantan Asmani Abdul Razak,
Norkhafizah Saddki, Nyi Nyi Naing, Nizam Abdullah (fizah@kb.usm.my)
Mini-Abstract
The objective of this study was to identify the characteristics of oral cancer among Malay patients in Hospital
Universiti Sains Malaysia (HUSM), Kelantan. A retrospective record review was conducted from August to
December 2006 in HUSM. Of 133 patients with oral cancer diagnosed from 1986 to 2005, 118 were Malay.
The prevalence of oral cancer among Malay patients in HUSM is high . It is predominantly found in elderly
males and the majority of cases present at advanced stage.
Asian Pacific J Cancer Prev, 10, 1131-1136
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Asian Pacific Organization for Cancer Prevention and Control

Induction of Apoptosis in the Human Leukemic U937 Cell Lineby Kaempferia parviflora Wall.ex.Baker Extract and Effectsof Paclitaxel and Camptothecin Ratana Banjerdpongchai, Yupa
Chanwikruy, Viboon Rattanapanone, Bungorn Sripanidkulchai
Mini-Abstract(ratana@chiangmai.ac.th)

Kaempferia parviflora Wall.ex.Baker is a Thai medicinal herb that has high antioxidant and anti-inflammatory
activities. Apoptotic effects of the herbal extract alone and in combination with chemotherapeutic drugs, paclitaxel
and camptothecin, were here studied in the human promonocytic leukemic U937 cell line. Mitochondrialtransmembrane potential (MTP) decreased after treatment and the number of cells with decreased MTP also
increased. Furthermore, activation of caspase-3 was found in herbal extract-treated cells.
Asian Pacific J Cancer Prev, 10, 1137-1140

Chemoprevention of 1,2-Dimethylhydrazine-Induced Colon
Carcinogenesis by a Non-Steroidal Anti-Inflammatory Drug,
Etoricoxib, in Rats: Inhibition of Nuclear Factor kB
Mini-Abstract

Lalita Tanwar, Vivek Vaish, SN Sanyal (sanyalpu@gmail.com)

Etoricoxib, a highly selective cyclooxygenase- 2 (COX-2) inhibitor, was studied for chemopreventive responsein the 1,2-dimethylhydrazine dihydrochloride (DMH) induced rat colon cancer model. The numbers of wellcharacterized pre-neoplastic features such as multiple plaque lesions (MPLs), aberrant crypts (ACs) and aberrant
crypt foci (ACF) were found to be reduced. Studies of a nuclear transcription factor (NF-kB) and COX-2 byWestern blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH
treated group but reduced in the DMH + Etoricoxib group.
Asian Pacific J Cancer Prev, 10, 1141-1146

Weekly Paclitaxel/ Docetaxel Combined with a Platinum in
the Treatment of Advanced Non-Small Cell Lung Cancer: aStudy on Efficacy, Safety and Pre-medication Jian-Nong Zhou,
Xin-En Huang, Zhuo Ye, Chao Li, Qian Zhang, Yong Lin, Wei Jiang,
Wei-Li Sun, Mei-Qi Shi, Yong-Qian Shu (huangxinen06@yahoo.com.cn)

Mini-Abstract

The objective was to evaluate the efficacy and safety of a weekly taxane schedule in the treatment of advanced
non small cell lung cancers (NSCLCs) and to generate anoptimal pre-medication protocol for weekly taxane.
Toxicity wa limited and no treatment related deaths occurred.The results showed that weekly administration of
paclitaxel /docetaxel is a safe and active protocol for advanced NSCLCs.
Asian Pacific J Cancer Prev, 10, 1147-1150

Pre-treatment Hemoglobin Levels are Important for Bladder
Carcinoma Patients with Extravesical Extension undergoing
Definitive Radiotherapy Vuslat Yurut-Caloglu, Murat Caloglu,
Mini-Abstract

Mustafa Kaplan, Osman Inci (vuslatyurut@yahoo.com)

This study waas performed to evaluate prognostic factors affecting local control (LC), distant metastasesfree survival (DMFS) and overall survival (OS) in bladder carcinoma patients undergoing extravesicalextension.The results showed the re-treatment Hb level to be the most important prognostic factor in patientstreated with definitive radiotherapy, so that anemia may act as a surrogate biological marker for aggressive
disease.
Asian Pacific J Cancer Prev, 10, 1151-1158
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

Histopathological Findings for Cervical Lesions in Malaysian
Women Al-Jashamy Karim, Redhwan Ahmed Al-Naggar, Poil San, M Mashani(jashamy@yahoo.com)

Mini-Abstract

The objective of this study was to determine the histopathological features and cell morphology of various
cervical lesions observed among Malaysian women. The histopathological results showed CIN I to be characterized
by mild papillary projections of the epithelium with some degree of nuclear enlargement, pleomorphism, mild
koilocytosis, bionucleated cells and a low nucleo-cytoplasmic ratio. CIN II demonstrated typical squamous
epithelium with disorganization of the lower part of the epithelium accompanied by nuclear hyperchromatism,an increased nucleo-cytoplasmic ratio, and scanty mitotic figures. CIN III was characterized by pleomorphic
nuclei, atypical cells with mitotic figures, nucleo-cytoplasmic ratio, anisokaryosis and hyperchromasia..
Asian Pacific J Cancer Prev, 10, 1159-1162

Colorectal Cancer Patients in a Tertiary Referral Centre in
Malaysia: a Five Year Follow-up Review Mohd Radzniwan A
Rashid, Aznida Firzah Abdul Aziz, Saharuddin Ahmad, Shamsul Azhar Shah,Ismail Sagap (drisagap@ppukm.ukm.my )Mini-Abstract
In Malaysia, colorectal cancer (CRC) is fast becoming the commonest cause of cancer death. This study
looked at the profile and outcome of five-year follow-up of patients with CRC. Male to female ratio was 1.2:1 with
Chinese predominance. Almost half of the patients defaulted follow up care, most often within the first year of treatment(22.4%) and the Chinese were the least likely to defaultSocio-demographic profile of CRC patients in UKMMC is
comparable to Asia pacific region. Apparent delay in seeking treatment gives rise to poor overall survival and local
recurrence rates.
Asian Pacific J Cancer Prev, 10, 1163-1166

Prevalence of Tobacco Use and Tobacco-dependent Cancers
in Males in the Rural Cancer Registry Population at Barshi,
India Ranjit V Thorat, Nandkumar S Panse, Atul M Budukh, Ketayun A
Mini-Abstract

Dinshaw, Bhagwan M Nene, Kasturi Jayant (barshivac@rediffmail.com)

In the Rural Cancer Registry at Barshi (western Maharashtra, India), it has been found that the incidence ofcancer is relatively low. The aim was to explain the low incidence of tobacco related cancers in males on thebasis of prevalence of their tobacco habits.Our findigns suggest that the low incidence of smoking dependent
cancers in males can be explained by the low prevalence of smoking habit but further studies are needed to
explain the observed incidence of predominantly chewing dependent cancers.
Asian Pacific J Cancer Prev, 10, 1167-1170

Significance of Alanine Aminotransferase Testing in Diagnosisof Acute and Chronic HBV Infection Ajay Kumar, Sanjay Pant,
Mini-Abstract

Sushil Narang(ajaykumarbiotech@rediffmail.com)

Diagnosis of hepatitis is made by biochemical assessment of liver function. Alanine aminotransferase (ALT),
a liver enzyme, is markedly elevated in hepatitis and with other causes of acute liver damage associated with
hepatic necrosis, blood levels being elevated even before the clinical signs and symptoms of disease such as
jaundice appear.In our study we found that 80% patients who were HBsAg positive had abnormal ALT levels,
while the remaining 20% had normal ALT values. This is despite suffering from acute or chronic liver disease,providing a reason why some patients positive for hepatitis B have a normal ALT.
Asian Pacific J Cancer Prev, 10,1171-1172
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Asian Pacific Organization for Cancer Prevention and Control

Identification of a Hepatitis B Virus Core Promoter Mutant
by PCR- RFLP in Patients Suffering from Chronic Liver
Disease, Uttar Pradesh, India Ajay Kumar, Balesh Kumar Tiwari, Ajay
Kumar Chaudhary, Sanjay Pant Sushil Narang (ajaykumarbiotech@rediffmail.com)
Mini-Abstract
The present study was designed to identify a core promotor mutation in the HBV genome in patients sufferingfrom HBV related chronic liver disease. The Sau3AI assay, which is much more convenient than sequencing,was shown to be useful for the detection of the core promoter mutant in an extensive number of clinical samples.
Monitoring and detection of HBV variants by PCR-RFLP in chronic infection may improve the management ofthese patients.
Asian Pacific J Cancer Prev, 10, 1173-1175

Lack of Effects of Single Nucleotide Polymorphisms of the DNA
Methyltransferase 1 Gene on Gastric Cancer in IranianPatients: A Case Control Study Fatemeh Khatami, Babak Noorinayer,
Somayeh Ghiasi, Reza Mohebi, Mohhamad Hashemi, Mohammad Reza Zali
(sKhatami@rigld.ir )Mini-Abstract
Hypomethylation and/or hypermethylation of DNA has been described in gastric cancer and is presumed to
be an early event in carcinogeneisis. We therefore hypothesized that single nucleotide polymorphisms of the
DNMT1 gene may be associated with the genetic susceptibility to gastric cancer.However, we could not show
any association between DNMT1 polymorphisms and gastric cancer. Larger sets of polymorphisms and sample
sizes are required for future testing of possible associations.
Asian Pacific J Cancer Prev, 10, 1177-1182

Effects of Amino Acid Substitution Polymorphisms of two DNA
Methyltransferases on Susceptibility to Sporadic Colorectal
Cancer Fatemeh Khatami, Babak Noorinayer, Seyed Reza Mohebi, Somayeh
Ghiasi, Mohhamad Hashemi, Mohammad Reza Zali (sKhatami@rigld.ir)
Mini-Abstract
The present study was designed to consider whether amino acid substitution polymorphisms in O6methylguanine-DNA methyltransferase (MGMT) and DNA methyl transferase 1 (DNMT1) genes may be
associated with the genetic susceptibility to sporadic colorectal cancer. The calculated odds ratios indicated noassociation for DNMT1. However, there was a significant association between two polymorphisms in MGMT
with sporadic colorectal cancer.
Asian Pacific J Cancer Prev, 10, 1183-1188

Colostomy Irrigation: An Important Issue for Muslim
Individuals
Ayise Karadag, Zehra Göçmen Baykara (Zubair.ahmad@aku.edu)
Mini-Abstract
Colostomy irrigation (CI) is a bowel management method in individuals with permanent colostomy, as analternative to pouch use, which may provide continence. CI helps the individuals with an artificial stoma toadjust to the stoma and may increase their quality of life (QOL). An uncontrolled intestinal gas discharge
invalidates ablution, and noisy gas discharge and smell prevents congregational prayers, which cause problems
to Muslims with stomas. Therefore, CI may be an appropriate solution for this patient group. Using the example
of one affected individual we discuss how the praying problem can be resolved with teaching to self-perform CI
and emphasize the beneficial effects on QOL.
Asian Pacific J Cancer Prev, 10, 1189-1190
APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

Proposal for a Cooperative Study on Population-based Cancer
Survival in Selected Registries in East Asia Hideo Tanaka, Masahiro
Tanaka, Wanqing Chen, Sohee Park, Kyu-Won Jung, Chun-Ju Chiang, MeiShu Lai, Maria Rica Mirasol-Lumague, Evlena Suzanna Sinuraya, Yoshikazu
Nishino, Akiko Shibata, Manabu Fujita, Midori Soda, Michiko Naito, Hideaki
Tsukuma, Malcolm A Moore, Wakiko Ajiki (hitanaka@aichi-cc.jp)
Mini-Abstract
Reliable population-based cancer survival data are essential for assessment of the effectivenes of cancer
screening programs, distribution of cancer therapy and prevalent cancer cases. International comparisons areuseful to allow societies, mass media and health authorities to gain a real appreciation of the cancer problem intheir own country and provide an impetus to improve registration and cancer control planning. Since directlycomparable survival data among East Asian countries are presently very limited, a comparative study on
population-based cancer survival involving China, Indonesia, Japan, Korea, the Philippines and Taiwan, with
Nepal as an observer, was proposed. At the 1st Working Group meeting in Tokyo on March 18th, 2009, it was
decided to publish the present Commentary as a step towards realization of truly comparable cancer survival
statistics in the region. Included are general information and quality of data of cancer registration at eachparticipating registry and five-year relative survival rates of cancer of the stomach, colo-rectum, liver, lung,breast and cervix.
Asian Pacific J Cancer Prev, 10, 1191-1198

Notes

APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
INFORMATION FOR AUTHORSAPJCP Editorial Office. The editorial offices are located in Thailand and Japan but submission is all electronic.
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Format:Brown A, Pink B, Black C, et al (2000). Cancer prevention in the Asian-Pacific. Asian Pac
J Cancer Prev, 8, 10-2.
Brown A, Pink B, Black C, et al (2000). Cancer prevention. In ‘Neoplasia’ , Eds Blue D
and Red E. Asian Pacific Education Press, Bangkok pp1-10
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INFORMATION FOR ANY INTERESTED IN BECOMING APOCPC MEMBERS
The bimonthly electronic Asian Pacific Journal of Cancer Prevention (APJCP) is published by the Asian PacificOrganization for Cancer Prevention and Control with support from the UICC-Asian Regional Office for Cancer Control
to promote increased awareness and knowledge in all areas of cancer prevention/control and to stimulate collaborative
efforts and practical intervention approaches in the different countries and states of the Asian Pacific region. The
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APJCP Vol 10, No 6

Asian Pacific Organization for Cancer Prevention and Control

CONTENTS APJCP Volume 10, Number 6, Nov-Dec 2009

MINI-REVIEWS
Curcumin: From Food Spice to Cancer Prevention Ademola A Oyagbemi et al

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963

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969

Toxicology of Engineered Nanomaterials - A Review of Carcinogenic Potential Hiroyuki Tsuda et al .

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975

Diverse Influences of Dietary Factors on Cancer in Asia Malcolm A Moore .

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981

Chronic Disease Prevention Research in Central Asia, the Urals, Siberia and Mongolia - Past, Present and Future Moore et al987

Cervical Cancer and HPV Vaccines in Developing CountriesMojgan Karimi Zarchi et al.

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RESEARCH COMMUNICATIONS
Hepatitis B Testing and Vaccination in Immigrants Attending English as a Second Language Classes in British Columbia, Canada
T Gregory Hislop et al
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997

Impact of Nutritional Status on the Quality of Life of Advanced Cancer Patients in Hospice Home Care Shahmoradi et al

1003

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Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: the Significance of Expression in Neoplastic Cells within the
Lymphovascular Space Jongkolnee Settakorn et al
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1011

Risk Factors for Prostate Cancer in Universiti Kebangsaan Malaysia Medical Centre: A Case-Control Study Subahir et al

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1015

Serum Granulocyte Macrophage-Colony Stimulating Factor: a Tumor Marker in Colorectal Carcinoma? Demirci et al

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1021

Changing Trends in Incidence of Ovarian Cancer - the Indian Scenario Nandagudi Srinivasa Murthy et al

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1025

Punarnavine Induces Apoptosis in B16F-10 Melanoma Cells by Inhibiting NF-kB Signaling Manu and Kuttan

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1031

Overview of Chronic Myeloid Leukemia Patients in Pakistan in the Pre-Imatanib Era Saad Z Usmani et al .

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1039

Clinical Outcome of the Ovarian Clear Cell Carcinoma Compared to other Epithelial Ovarian Cancers when Treated with
Paclitaxel and Carboplatin Daranee Sirichaisutdhikorn et al
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1041

Women’s Awareness, Knowledge and Perceived Magnitude Regarding Common Female Cancers in Yangon, Myanmar Mon et al1047

Vinorelbine in Combination with Carboplatin followed by Single-agent Consolidation Therapy for Unresectable Localized orMetastatic Non-small-cell Lung Carcinomas Suleyman Alici et al
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1051

XRCC1399 and hOGG1326 Polymorphisms and Frequencies of Micronuclei, Comet and Chromosomal Aberrations among Tobacco
Chewers: A South Indian Population Study Sellappa et al .
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1057
Screening of N-ras Gene Mutations in Urothelial Cell Carcinomas of the Urinary Bladder in the Kashmiri Population Pandith et al
Status of Male Breast Carcinomas in Pakistan Jamal et al

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1063

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1067

Neoplasia/dysplasia Surveillance of Oral Lichen Planus in Malaysia: a Preliminary Study using Topography Maps Lim et al .

1071

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1075

Breast Carcinoma in Young Women Aged 30 or Less in Northern Pakistan - Armed Forces Inst. of Pathology Mamoon et al .

Eight Year Survival among Breast Cancer Malaysian Women from University Kebangsaan Malaysia MC Al-Naggar et al1079

Complementary and Alternative Medicine in Cancer Patients - Analysis of Influencing Factors in Turkey Malak et al

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1083

Anti-tumor Activity of Phyllanthus niruri (a Medicinal Plant) on Chemical-induced Skin Carcinogenesis in Mice Sharma et al1089

Screening and Perceived Severity of Cervical Cancer among Women Attending Mahalapye District Hospital, Botswana Hoque et al1095

Perspectives on Strategies for Establishing Cancer on the Global Health Agenda: Possibilities of Creating Infrastructure forPrevention Information using School Health Classes Norie Kawahara
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1101

Sida rhombifolia Seed Extract Inhibits DEN Induced Murine Hepatic Preneoplasia and CCl4 Hepatotoxicity Poojari et al.

Impact of a Health Education Intervention Program Regarding Breast Self Examination in Madhya Pradesh, India Gupta et al

1107
1113

Clinical Evaluation of Parapelvic Renal Cysts: Do These Represent Latent Urological Malignant Disease? Umemoto et al

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1119

Histopathological Patterns of Female Breast Lesions at a Secondary Level Care in Saudi Arabia Tarek Tawfik Amin et al

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1121

Influence of Matrix Metalloproteinase Gene Polymorphisms in Healthy North Indians Compared to Variations in other Ethnic
Groups Worldwide Priyanka Srivastava et al
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1127

Oral Cancer Presentation Among Malay Patients in Hospital Universiti Sains Malaysia, Kelantan Razak et al

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1131

Induction of Apoptosis in the Human Leukemic U937 Cell Line by Kaempferia parviflora Wall.ex.Baker Extract and Effects of
Paclitaxel and Camptothecin Ratana Banjerdpongchai et al
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1137

Chemoprevention of 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis by a Non-Steroidal Anti-Inflammatory Drug,
Etoricoxib, in Rats: Inhibition of Nuclear Factor kB Lalita Tanwar et al .
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1141

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Weekly Paclitaxel/ Docetaxel Combined with a Platinum in the Treatment of Advanced Non-Small Cell Lung Cancer: a Study on
Efficacy, Safety and Pre-medication Jian-Nong Zhou et al
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1147

Pre-treatment Hemoglobin Levels are Important for Bladder Carcinoma Patients with Extravesical Extension undergoing
Definitive Radiotherapy Vuslat Yurut-Caloglu et al
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1151

Histopathological Findings for Cervical Lesions in Malaysian Women Al-Jashamy Karim et al.

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1159

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1163

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Colorectal Cancer Patients in a Tertiary Referral Centre in Malaysia: a Five Year Follow-up Review Rashid et al

Prevalence of Tobacco Use and Tobacco-dependent Cancers in the Rural Cancer Registry Population at Barshi, India Thorat et al1167

Significance of Alanine Aminotransferase Testing in Diagnosis of Acute and Chronic HBV Infection Ajay Kumar et al

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1171

Identification of a Hepatitis B Virus Core Promoter Mutant by PCR- RFLP in Patients Suffering from Chronic Liver Disease,
Uttar Pradesh, India Kumar et al
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1173

Lack of Effects of Single Nucleotide Polymorphisms of the DNA MT 1 Gene on Gastric Cancer in Iran Khatami et al .

1177

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Effects of Amino Acid Substitution Polymorphisms of two DNA Methyl-transferases on Sporadic Colorectal Cancer Khatami et al

1183

COMMENTARIESColostomy Irrigation: An Important Issue for Muslim Individuals Karadag and Baykara

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Proposal for a Cooperative Study on Population-based Cancer Survival in Selected Registries in East Asia Tanaka et al

APJCP Vol 10, No 6

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