International Society for Neurochemistry
Application for Support of ISN Schools
The application form should be returned to Dr. Yasuharu Shinoda by e-mail1.

Contact details of the applicant(s):Chairperson: Professor Kohji Fukunaga
Address(s): Department of Pharmacology, Tohoku University Graduate School of
Pharmaceutical Sciences, Sendai 980-8578, Japan
Tel No(s): +81-22-795-6836
Fax No(s): +81-22-795-6835
Or Local Organizer: Assistant professor Yasuharu Shinoda
E-mail address: yshinoda@tohoku.ac.jp

2.

Theme of School:
ISN-APSN Advanced School, Sendai 2017 entitled"Novel Dimensions in Neurochemical Research; from molecular biology to brain
imaging.’’

3.

4.

Place and date of the school:l

Venue : Tohoku University, Graduate Schools of Pharmaceutical Sciences and Life
Sciences, Sendai 980-8578, Japanl

Date : To be held between September 2-6, 2017.

Justify why the school is relevant to advanced training of future neuroscientists in
APSN and why ISN should support it:
The main objective of the APSN-ISN School (Sendai 2017) is to provide novel a collaborative
platform enabling PhD students and postdoctoral fellows from various fields of neurochemical
research to meet and exchange ideas and experiences. The participants can enjoy the wide
variety of leading edge neurochemical research. We will provide world-renowned researchersin Tohoku University Comprehensive Center For Brain Science Research and Education(Tohoku University Brain Science Center: TU-BSC) to train the attendees with updated
knowledge of advanced brain imaging, optogenetic and neurochemical techniques, especiallyon the neuropsychiatry diseases such as depression, autism, schizophrenia and the neuralcircuits involved in memory and cognition. Therefore, the participants will acquire new ideas
and learn new technology and methods that will be beneficial to their future research.
The School (Sendai, 2017) will be jointly sponsored by International Society for
Neurochemistry (ISN) and Asian-Pacific Society for Neurochemistry (APSN), in partnershipwith the Japanese Society for Neurochemistry (JSN).

1

Applications for participation in the School will be made by Ph.D students or postdoctral
fellows who are within 5 years of graduating with their Ph.D. Applicants are also limited within
the Asian-Pacific region and selected by a School Organizing Committe formed by membersof APSN and the local organizing committee (LOC). The applicants will need to submit two
letters of recommendation from faculties of department or university where the applicants are
studying and their CVs. Decisions will be made according to merit of plus a first-in and lastout principle.
Tohoku University Comprehensive Center for Brain Science Research and Education (TUBSC) is one of the most distinguished research centers in Japan and with more than 60
professors of various brain research fields. The TU-BSC faculties also belong to the graduate
schools of medicine, medical technology, life sciences and pharmaceutical sciences in
Tohoku Universirty. To strengthen the friendship between the school faculties, students andhost, the Local Organizing Committee will also arrange social activities and a culturalexperience (for details see the preliminary program).
5.

Name of body organising the school (if appropriate) and names of the members of theorganising committee:
Organizers:l Asian-Pacific Society for Neurochemistry (APSN)l Japanese Society for Neurochemistry (JSN)l Tohoku University Comprehensive Center for Brain Science Research and Education(TU-BSC)
School Organizing Committee:
Members from the APSN :lAkio Wanaka, Japan (APSN President)
Ying-Shing Chan, Hong Kong (APSN Secretary)
Woong Sun (APSN Treasurer)
Andrew Lawrence, Australia （APSN past president）
Chian Ming Low (APSN School Committee Chair)
Kazuhiro Ikenaka, Japan (ISN Treasurer)
Shinchi Hisanaga (ISN Council member)l

Members of Local Organizing Committee (LOC):
Kohji Fukunaga (Professor, Tohoku University Graduate School of Pharmaceutical
Sciences)
Shozo Furumoto ((Professor, Tohoku University Graduate School of Pharmaceutical
Sciences)
Toshio Iijima (Drector of TU-BCS, Professor Emelitus, Tohoku University)
Hiroshi Inada (Senior Assistant Professor, Tohoku University Graduate School of
Medicine)
Ko Matsui (Professor, Tohoku University Graduate School of Life Sciences)
Shigeki Moriguchi (Senior Assistant Professor, Graduate School of Pharmaceutical
Sciences)
Hajime Mushiake (Professor, Tohoku University Graduate School of Medicine)
Katsuhiko Nishimori (Professor, Tohoku University Graduate School of Agricultural
Science)
Ichiko Nishijima (Senior Assistant Professor, Tohoku University Graduate School of
Medicine)
Noriko Osumi (Professor, Tohoku University Graduate School of Medicine)
Tetsuya Terasaki (Professor, Tohoku University Graduate School of Pharmaceutical
Sciences)
Masanori Tachikawa (Associate Professor, Tohoku University Graduate School of
Pharmaceutical Sciences)
Hiroaki Tomita (Professor, Department of Disaster Psychiatry, International ResearchInstitute of Disaster Science, Tohoku University)2

Ken-Ichiro Tsutsui (Professor, Tohoku University Graduate School of Life Sciences)
Daisuke Yamamoto (Professor, Tohoku University Graduate School of Life Sciences)
Kazuhiko Yanai (Professor, Tohoku University Graduate School of Medicine)
Yasushi Yabuki (Assistant Professor, Tohoku University Graduate School of
Pharmaceutical Sciences)
Secretary : Yasuharu Shinoda (Assistant Professor, Tohoku Univeristy Graduate
School of Pharmaceutical Sciences
6.

School program (day by day activities):

The School will provide a 5-day program including both comprehensive lectures and hands-on
techniques associated with neurochemical, electrophysiological, optogenetic studies and brain
imaging.

Participants from oversea countries shall arrive in Japan on September 1st, 2017.
The lodging for these students will be provided by the LOC.
Participants will get together at Lecture Room of Tohoku University Graduate Schoolof Life Sciences by 9 :30 AM of September 2nd.
Day 1 : Saturday, September 2，2017
Lecture series of Hands-on techniques will be held at
Lecture Room in Graduate School of Life Sciences.
(1) Interactions between school faculties and students(2) Hands-on grouping (2 participants/group, only one
module for each participant during the school period)

9:30-12 :00

30-minute lectures including 10 min discussion will begiven by the module leaders (10 faculties) (Coffee breaks
between lectures).
Module 1: Brain imaging of Alzheimer disease andneuropsychological diseases (by Profs. Furumoto andYanai)
Module 2: Non-human primate neurophysiology for theinvestgation of higher cognitive functions (by Profs.
KenichiroTsutui and Mushiake)

12:00-13:00

Lunch (at the restaurant, Sakura Kitchen)
Module 3: Molecular mechanisms of neurodegenerationand neuropsychiatry disease (by Profs.Inada andFukunaga)

13 :00-18 :00

Module 4 :・Optogenetic control of glial activity and animal behavior(by Prof. Ko Matsui)
Coffee break
Module 5 :・Recent Advances in Blood-Brain Barrier Transport3

Research (by Prof. Tetsuya Terasaki)

18 :00-20 :00

Module 6 : Molecular basis of innate behaviors in
Drosophila (by Prof. Yamamoto)Welcome Dinner (at the restaurant, Sakura Kitchen)

Day 2 : Sunday September 3, 2017
Module 7 : Molecular basis of autism behaviors in oxytocin
null mice (by Profs. Nishimori and Yabuki)
Coffee break

9 :00-12 :00

12 :00-13 :00

13 :00-16 :00

Module 8:
・ Psychological Impact of the Great East Japan
Earthquake How Science can contribute the recovery (byProf Hiroaki Tomita)
・Construction of biobank in Tohoku Medical Megabank
Organization for a part of reconstruction from Great East
Japan Earthquake ( by Prof Ichiko Nishijima)

Lunch (Lunch box)
Five min poster presentation with a 5-min discussion by
20 students.
Organized by Andrew Lawrence, Australia (APSN past
President), Akio Wanaka, Japan (APSN President), YingShing Chan (APSN Secretary), Chian Ming Low (APSN
School Committee Chair).

16 :00-17 :00

Advanced Lecture 1: Impact of maternal fatty acids on
brain development and behavior in the oddspring (Prof.
Noriko Osumi)

18:00-19:00
19:00-21:00

Dinner (at Lodging Hotel)
Meet the speaker (Prof. Noriko Osumi)

Day 3 : Monday, September 4，2017
One day trip to promote friendship between participants
and foreign students studing in Tohoku University.
Participants will learn how peoples come back from theGreat East Japan Earthquake in Sendai.
9 :30-18 :00
Participants will visit Ishinomaki Community andInfomation Center and talk with Richard Halberstadt, Chiefof the Center. He will talk that working together for a new
Ishinomaki after the Earthquake.
18:00-19:00
Dinner (at Lodging Hotel)
19:00-20:00
Group meeting for hands-on techniques for days 5 and 6
Day 4 : Tuesday, September 5，2017
Hands-on techniques
Module 1 : Brain imaging of Alzheimer disease andneuropsychological diseases (Two Labs)
9 :30-12:00
Module 2 : Neural circuits involved in cognition andemotion in monkey brain (Two Labs)
Module 3 : Molecular mechanisms of neurodegeneration

4

and neuropsychiatry disease (Two Labs)
Module 4 : Neural function analyses using Optgenetics(One Lab)
Module 5 : Molecular basis of blood brain barrier and drugtransport (Two Labs)
Module 6 : Molecular basis of innate behaviors in
Drosophila (One Lab)
Module 7 : Molecular basis of autism behaviors in oxytocin
null mice (One Lab)
Module 8: Mental health promotion and life sciences in
Tohoku Medical Megabank after the Great East Japan
Earthquake (One Lab)
12 :00-14 :00

14 :00-18 :00

17:00-18:00
18:00-19:00

Lunch
Hands-on techniques
Module 1 : Brain imaging of Alzheimer disease andneuropsychological diseases (Two Labs)
Module 2 : Neural circuits involved in cognition andemotion in monkey brain (Two Labs)
Module 3 : Molecular mechanisms of neurodegenerationand neuropsychiatry disease (Two Labs)
Module 4 : Neural function analyses using Optgenetics(One Lab)
Module 5 : Molecular basis of blood brain barrier and drugtransport (Two Labs)
Module 6 : Molecular basis of innate behaviors in
Drosophila (One Labs)
Module 7 : Molecular basis of autism behaviors in oxytocin
null mice (One Labs)
Module 8: Mental health promotion and life sciences in
Tohoku Medical Megabank after the Great East Japan
Earthquake (One lab)

Dinner In Local food restaurant (Japanese)
Advanced Lecture 2 : How do ISN and APSN succeed in
Neurochemical Research (Prof, Andrew Lawrence APSN
past president).

19:00-21:00

Free talk with Andrew Lawrence, Australia (APSN past
President), Akio Wanaka, Japan (APSN President), YingShing Chan (APSN Secretary), and Chian Ming Low(APSN School Committee Chair).

Day 5 : Wenseday, September 6，2017
Hands-on techniques
Module 1 : Brain imaging of Alzheimer disease andneuropsychological diseases (Two Labs)
Module 2 : Neural circuits involved in cognition andemotion in monkey brain (Two Labs)
9 :00-12 :00
Module 3 : Molecular mechanisms of neurodegenerationand neuropsychiatry disease (Two Labs)
Module 4 : Neural function analyses using Optgenetics(Two Labs)
Module 5 : Molecular basis of blood brain barrier and drugtransport (Two Labs)

5

Module 6 : Molecular basis of innate behaviors in
Drosophila (One Lab)
Module 7 : Molecular basis of autism behaviors in oxytocin
null mice (One Lab)
Module 8 : Module 8: Mental health promotion and life
sciences in Tohoku Medical Megabank after the Great
East Japan Earthquake (One Lab)
12 :00-13 :00

13 :00-17 :00

18 :00-20 :00

7.

Lunch
Advanced Lecture 3: Structural and functional
characterization of alpha-synuclein assemblies in
Parkinson’s disease and related synucleinopathies (Prof
Ronald Melki, Paris-Saclay Institute of Neuroscience).
And join to International meeting of “Protein misfolding
disease and Therapy 2017 in Sendai” to discuss withleading neuroscientists in the world.
Farwell party for APSN-ISN advanced shool memberswith staffs

Names and affiliations of School Faculty:

Overseas Faculties (supported by ISN):
Professor Chian Ming Low
Department of Pharmacology and Anaesthesis, National Univeristy Hospital Singapore, Singapore
e-mail : phclowcm@nus.edu.sg
Professor Ying-Shing Chan
School of Niomedical Sciences The University of Hong Kong (APSN Secretary) e-mail:yschan@hku.hk
Professor Andrew J. Lawrence
NHMRC Senior Research Fellow
Howard Florey InstituteCentre for Neuroscience
University of Melbourne
Tel: 03 90356692; Mobile: 0431 267795
e-mail: andrew.lawrence@florey.edu.au
LOC faculties (supported by ISN)
Professor Akio Wanaka
Department of Anatomy and Neuroscience
Nara Medical University School of Medicine
e-mail: akiow@naramed-u.ac.jp
Professor Shin-ichi Hisanaga
Department of Molecular Neuroscience
Graduate School of Sciences
Tokyo Metropolitan University
e-mail: hisanaga-shinichi@tmu.ac.jp
LOC faculties (supported by LOC)
Kohji Fukunaga, Professor, Tohoku University Graduate School of Pharmaceutical Sciences
E-mail :kfukunaga@m.tohoku.ac.jp
Shozo Furumoto, Professor, Tohoku University Graduate School of Pharmaceutical Sciences6E-mail :furumoto@cyric.tohoku.ac.jp
Toshio Iijima, Drector of TU-BCS, Professor Emelitus, Tohoku University
E-mail :t-iijima@m.tohoku.ac.jp
Hiroshi Inada, Senior Assistant Professor, Tohoku University Graduate School of Medicine
E-mail :hinada@med.tohoku.ac.jp
Ko Matsui, Professor, Tohoku University Graduate School of Life Sciences
E-mail : matsui@med.tohoku.ac.jp
Shigaki Moriguchi, Senior Assistant Professor, Graduate School of Pharmaceutical Sciences
E-mail : shigeki@m.tohoku.ac.jp
Hajime Mushiake, Professor, Tohoku University Graduate School of Medicine
E-mail : hmushiak@med.tohoku.ac.jp
Ichiko Nishijima, Senior Assistant Professo, Tohoku University Tohoku Medical Megabank
Organization. E-mail : nishijii@med.tohoku.ac.jp
Katsuhiko Nishimori (Professor, Tohoku University Graduate School of Agricultural Science)
Noriko Osumi, Professor, Tohoku University Graduate School of Medicine
E-mail : osumi@med.tohoku.ac.jp
Tetsuya Teraski, （Professor, Tohoku University Graduate School of Pharmaceutical Sciences）
E-mail : terasaki@mail.pharm.tohoku.ac.jp
Masanori Tachikawa (Associate Professor, Tohoku University Graduate School of Pharmaceutical
Sciences) E-mail:tachikaw@m.tohoku.ac.jp
Hiroaki Tomita (Professor, Department of Disaster Psychiatry, International Research Institute ofDisaster Science, Tohoku University) E-mail:htomita@med.tohoku.ac.jp
Ken-Ichiro Tsutsui, Associate Professor, Tohoku University Graduate School of Life Sciences
E-mail :tsutsui@m.tohoku.ac.jp
Daisuke Yamamoto, Professor, Tohoku University Graduate School of Life Sciences
E-mail : daichan@m.tohoku.ac.jp
Kazuhiko Yanai, Professor, Tohoku University Graduate School of Medicine
E-mail : yanai@med.tohoku.ac.jp
Yasushi Yabuki, Assistant Professor, Tohoku Univeristy Graduate School of Pharmaceutical Sciences
E-mail :yabukiy@m.tohoku.ac.jp

8.

Estimated number of students, estimated international and national distribution, andactivities at the school (e.g. number of expected students, lectures, laboratory
modules, posters, etc)l

Estimated number of students and distribution:
National (Japan) =5
Asian-Pacific region =15l Activities at the school
The school includes ten 30-min lectures (12 technical lectures for hands-on modules and 2
advanced lectures), plus 10 laboratory hands-on modules. Each module lasts two days.
Totally, lecture time=6 hours, laboratory hands-on module time=12 hours (during 2 days). For
details see as follows:

Lectures for Modules :Module 1: Brain imaging of Alzheimer disease and neuropsychological diseases (by Profs. Furumoto
and Yanai)Prof. Shozo Furumoto
PET IMAGING TRACERS FOR TAU PATHOLOGY IN ALZHEIMER DISEASE
Prof. Kazuhiko Yanai
PET IMAGING AGENT THAT BINDS TO AMYLOID PLAQUES FOR THE POTENTIAL DETECTION
OF ALZHEIMER’S DISEASE
Module 2: Neural circuits involved in cognition and emotion in monkey brain (by Profs. Tsutsui and
Mushiake)

7

Prof. Ken-ichiro Tsutsui
TRANS-CRANIAL MAGNETIC STIMULATION (TMS): A NEW TOOL FOR ANIMAL RESEARCH IN
SYSTEMS NEUROSCIENCE
Prof. Hajime Mushiake
BEHAVIORAL UPDATING AND MAINTENANCE IN THE MEDIAL FRONTAL AREAS
Module 3: Molecular mechanisms of neurogeneration and neuropsychiatry disease (by Profs.Osumi
and Fukunaga )Prof. Noriko Osumi
SIGNIFICANT IMPACT OF FATTY ACID SIGNALS ON PRE- AND POST-NATAL BRAIN
DEVELOPMENT AND THEIR OUTCOME
Prof. Kohji Fukunaga
POST-TRAUMATIC STRESS DISORDER (PTSD)-LIKE BEHAVIORS WITH IMPAIRED CINGULATECORTEX IN FABP3 NULL MICE
Module 4 : Functional analyses of Optogenetic studies (by Profs. Matsui and Ishizuka)
Prof. Ko Matsui
OPTOGENETIC CONTROL OF ASTROCYTIC ACTIVITY
Prof. Toru Ishizuka
OPTOGENETIC SILENCING OF NEURONAL ACTIVITY USING A LIGHT-DRIVEN SODIUM ION
PUMP IN MARINE BACTERIA
Module 5 : Molecular basis of blood brain barrier and neurovascular units (by Profs. Terasaki and Han)
Prof. Tetsuya Terasaki
QUANTITATIVE TARGETED ABSOLUTE PROTEOMICS OF RAT BLOOD-CEREBROSPINALFLUID BARRIER TRANSPORTERS : COMPARISON WITH A HUMAN SPECIMENProf Feng Han
RESOLUTION THE INFLAMMATORY RESPONSE DURING NEUROVASCULAR DAMAGE:CROSS-TALK BETWEEN MICROVESSELS AND NEURONS
Module 6 : Molecular basis of innate beheviors in Drosophila (by Prof. Yamamoto)Prof Daisuke Yamamoto
THE NEURAL BASIS FOR EXPERIENCE-DEPENDENT MODIFICATIONS OF MALE COURTSHIPIN DROSOPHILA
Module 7 : Molecular basis of autism behaviors in oxytocin null mice (by Prof. Nishimori)Prof. Katsuhiko Nishimori
OXYTOCIN CONTROLS SOCIAL BEHAVIORS THROUGH ITS RECEPTOR EXPRESSED INGABAERGIC NEURONS DISTRIBUTED IN MEDIAL AMYGDALA AND LATERAL SEPTUM
Module 8 : Mental health promotion and life sciences by the Medical Megabank in Tohoku University
after the Great East Japan Earthquake (by Profs. Nishijima and Tomita)
Prof. Nishijima
Title :
Prof Hiroaki Tomita
Title :

Laboratory hands-on modules (2 day’s modules):Module 1: Brain imaging of Alzheimer disease and neuropsychological diseases (Labs of Profs.
Furumoto or Yanai)

8Module 2: Neural circuits involved in cognition and emotion in monkey brain (Labs of Profs. Tsutsui
and Mushiake)
Module 3: Molecular mechanisms of neurodegeneration and neuropsychiatry disease (Labs ofProfs.Osumi and Fukunaga )Module 4 : Functional analyses of Optogenetic studies (Labs of Prof. Matsui)
Module 5 : Molecular basis of blood brain barrier and neurovascular units (Labs of Profs. Teraaski
and Han)Module 6 : Molecular basis of innate behaviors in Drosophila (Lab of Prof. Yamamoto)
Module 7 : Molecular basis of autism behaviors in oxytocin null mice (Lab of Prof. NIshimori)
Module 8 : Mental health promotion and life sciences by the Medical Megabank in Tohoku University
after the Great East Japan Earthquake (Lab of Profs Nishijima and Tomita)

School students’ oral presentations

10.

In the Afternoon session on the school Day 2, students will present orally their experimental
results using posters. Each oral presentation will be limited to 10 min. The presentation will bechaired by School Faculties. Three of the presentations will be awarded as gold, silver andbronze medals.
Previous applications for ISN support by the applicant(s) (organiser, group oforganisers or the organising society)
The LOC have not previously been funded from the ISN-SC; however APSN schools are
regularly funded under this scheme.

Chairperson of the organising committee, agree:
1. to acknowledge ISN support in all publicity (conference announcements, website, abstract bookand other publications, etc) pertinent to the school.
2. to publicly announce the availability of application forms for ISN membership on The World’s
Neurochemistry Portal (http://www.neurochem.org) and to support the effort of ISN to recruit new
members.
3. to submit my report on the school plus photographs (as specified in Guidelines), within one monthof the end of the school.
4. to spend the ISN funds in accordance with the ISN Schools Guidelines.
Name(s) and Signature(s) of applicant(s):Kohji Fukunaga, PhD
Professor,
Department of Pharmacology
Tohoku University Graduate School of Pharmaceutical Sciences9

Sendai 980-8578, Japan
E-mail : kfukunaga@m.tohoku.ac.jp
Date: January 7, 201610