ISSN 1881ー4980

信 州 大 学 医 学 部 医 学 科・大 学 院 医 学 系 研 究 科・医 学 部 附 属 病 院 業 績 録

SCIENTIFIC ACHIEVEMENTS OF SHINSHU UNIVERSITY SCHOOL OF
MEDICINE, SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE,
AND SHINSHU UNIVERSITY HOSPITAL
信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録

No.45 (2016)

第四五号（二〇一六 ）
二〇一七

2017

信大
州学
大医
学学
医部
学業
部績
業録
績編
録集
編要
集項
要（
項抜粋）
信州

あ

（平成28年12月29日改正）

１．収録対象 ２．収録対象
 信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で信州大学医学部医学科・大学院医学系研究科・医学部附属病院及び出版委員会で認めた施設等に所属する者（当該年に在籍した者全員）認めた施設等に所属する者（当該年度に在籍した者全員）
２．収録内容 ３．収録内容
収録対象は、本文が欧文で執筆された研究業績とし、次の３項目に分ける。
研究業績を次の２項目に分ける。
１）論文
１）論文
原著、綜説、展望、症例報告、速報、予報で、査読のある学術雑誌に発表のもの。
原著、綜説、展望、症例報告、速報、予報で学術雑誌に発表のもの。
学
 術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をも
学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をもち、ち、別刷が発行されているもの）
別刷が発行されているもの）
２）著書
２）著書
単行書、分担執筆。
単行書、分担執筆。
３）その他
治
 療指針、トピックス、事典等、専門的知見にもとづき執筆された、論文形式の
ただし、以下のものは除外する。
記事（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表に関するもの及び１頁ものの速報は抄録とみなす）
ただし、以下のものは除外する。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表（ハ）業務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）
に関するもの及び１頁ものの速報は抄録とみなす）（ニ）座談会記事。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（ホ）学会記。
（ハ）業and
務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）（ヘ）質疑応答（ＱＡ）
、治療指針、問題集の解説、トピックス、話題、グラビア、
（ニ）
座
談会記事。
事典等に類するもの。
（ホ）学会記。
（ト）新聞記事、教育に関する記事、人物紹介、書評、随筆など学術性が認められ（ヘ）
ないもの。 論文形式をとらない質疑応答（Q and A）、問題集の解説、話題、グラビア等に類するもの。
（チ）著者表示が団体名で個人の著者性が認められないもの。
（ト）新聞・週刊誌記事、教育に関する記事、人物紹介、書評、随筆など学術性が（リ）学術雑誌とは認められないものに発表したもの。
認められないもの。
（ヌ）訳本及び訳論文。
（チ）著者表示が団体名で個人の著者性が認められないもの。
４．収録期間
毎年１月～12月とがき

信州大学医学部医学科
・大学院医学系研究科・医学部附属病院業績録第45号をお届けします。
信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録第38 号をお届けします。
本業績録は過去１年間、各教室や部門などでなされた４つの活動（研究活動、教育活動、診本業績録は過去１年間、各講座や部門等でなされた４つの活動（研究、教育、診療、社会貢献）
療活動、社会貢献）のうち、研究活動の成果として公表された論文を中心にまとめたものです。
のうち、研究活動の成果として公表された論文を中心にまとめたものです。自己点検、自己評
自己点検、自己評価、学内・学外への報告において、本業績録の役割は重要と思われます。この１年の研究活動を振り返り、今後の方向性を考える契機にしていただければ幸いです。
価、学内外への報告において、本業績録の果たす役割は重要と思われます。このような観点から、
この１年間の研究活動を振り返り、今後の方向性等を考える契機にしていただけたら幸いに存
医学論文数の動向をみると、トップの米国以下、英独さらには豪印中国などの伸びが目立つじます。
なか、わが国は2000年頃から停滞ないし低い伸びにとどまっており、基礎および臨床医学とも、世界における存在感の低下が続いています。これには大学予算の減額や、新臨床研修制度下での若手医師の大学離れによる研究者の減少など、様々な要因が指摘されており、信州大学もこ
今年度の英文論文総数は昨年度より微減し、90 年度以降で最も少ない 386 という結果となり
れらの影響を無視することはできません。しかし、そのなかで2016年度も461本の英文業績がました。しかしながら、単なる総数のみの評価が必ずしも適切であるとは言えず、今年度の業発表されました。この１つ１つが多くの先生方のご努力の賜物でありますが、今後も、医学の発展に大きく寄与するような瞠目すべき成果が、ここ信州の地から次々と発信されていくこと
績の中には極めて質の高い研究成果も少なくありません。今日、卒業生の大学離れや医学科入を期待したいと思います。
学定員数増加等により、診療や教育活動等の業務負荷は増加の一途にあります。このような現状ではありますが、研究活動は大学が大学であるための大きな責務であり、外部評価基準の重最後に、本業績録の編集にあたりご尽力頂きました先生方、図書館職員の方々に厚く御礼申
要項目であることは言うまでもありません。今後、各講座・部門等でのさらなる研究の発展をし上げます。



祈念致します。

鷲塚伸介

出 最後に、本業績録の編集にあたりご尽力頂きました先生方、図書館職員の方々に厚く御礼申
版 委 員 長：鷲塚伸介
出し上げます。
版 委 員：中沢洋三、伊東清志、森政之
医学部図書館主査：岩井雅史
浅村英樹
出 版 委 員 長：浅村英樹
出版

委員：奥山隆平、石田文宏、川股知之

医学部図書館主査：石坂憲司

信州大学医学部医学科・大学院医学系研究科
・医学部附属病院業績録 第
第 45
38 号
号
平成
2830
日印刷
平成 23
29 年１月年 11 月
日印刷
平成
2830
日発行
平成 23
29 年１月年 11 月日発行
編集兼 信 州 大 学 医 学 部
発行者 松本市旭 3 丁目 1 の 1
印刷所

藤原印刷株式会社

松本市新橋 7 の 21 番地

a

SCIENTIFIC ACHIEVEMENTS OFSHINSHU UNIVERSITY SCHOOL OF MEDICINE,SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE,
AND SHINSHU UNIVERSITY HOSPITAL

信州大学医学部医学科・大学院医学系研究科・
医学部附 属 病 院 業 績 録
No. 45（ 2 0 1 6 ）

2017

b

1

I. Scientific Achievements of Shinshu University School of Medicine,
Shinshu University Graduate School of Medicine,and Shinshu University HospitalContents
Histology and Embryology...........................................3

Obstetrics and Gynecology.........................................20

Anatomy........................................................................3

Anesthesiology and Resuscitology.............................20

Physiology....................................................................3

Laboratory Medicine...................................................20

Molecular Cellular Physiology.....................................3

Emergency and Critical Care Medicine......................22

Pathology......................................................................3

Comprehensive Cancer Therapy.................................23

Pathobiology.................................................................4

Brain Disease Research...............................................24

Microbiology and Immunology....................................4

Neonatology................................................................24

Medical Genetics..........................................................4

Occupational Health....................................................25

Preventive Medicine and Public Health........................5Hearing Implant Sciences...........................................26

Legal Medicine.............................................................5

Center for Medical Education and Clinical Training...26

Internal Medicine 1.......................................................6

Aging Biology.............................................................26

Internal Medicine 2.......................................................6

Neuroplasticity............................................................26

Internal Medicine 3.......................................................8

Molecular Pathology...................................................26

Internal Medicine 4.......................................................9Metabolic Regulation..................................................27

Internal Medicine 5.......................................................9

Cardiovascular Research.............................................28

Psychiatry....................................................................10

Sports Medical Sciences.............................................28

Pediatrics.....................................................................11

Blood Transfusion Center...........................................28

Dermatology...............................................................12

Rehabilitation Center..................................................28

Radiology....................................................................14

Medical Informatics ...................................................29

Surgery 1.....................................................................14

Center for Medical Genetics.......................................29

Surgery 2.....................................................................15

Cochlear Implant Center.............................................30

Orthopaedic Surgery...................................................16

Advence Center for Cellular Therapy.........................30

Neurosurgery...............................................................17

Department of Pharmacy............................................30

Dentistry & Oral Surgery............................................18

Clinical Resident Training Center...............................30

Urology.......................................................................19

Laboratory of Animal Research..................................30

Ophthalmology...........................................................19

Radioisotope Experiments..........................................31

Otorhinolaryngology...................................................19

2

3

Histology and Embryology
20160001
Tomotsune D, Hirashima K, Fujii M, Yue
F, Matsumoto K. Takizawa-Shirasawa S, Yokoyama T,
Sasaki K : Enrichment of Pluripotent Stem Cell-Derived
Hepatocyte-Like Cells by Ammonia Treatment. PLoS ONE
11: e0162693, 2016.

Anatomy20160002
Kuroiwa M, Fukushima N, Yokouchi K,
Kawagishi K, Moriizumi T : Morphological analysis ofregenerated bulbar fibers in relation to neonatal olfaction.
Brain Res Bull 127: 66-73, 2016.

Physiology
20160003
Kakino A, Fujita Y, Nakano A, Horiuchi S,
Sawamura T : Developmental endothelial locus-1 (Del-1)
inhibits oxidized low-density lipoprotein activity by directbinding, and its overexpression attenuates atherogenesis inmice. Circ J 80: 2541-2549, 2016.
20160004
Chen M, Qiu H, Lin X, Nam D, OgbuNwobodo L, Archibald H, Joslin A, Wun T, Sawamura
T, Green R : Lectin-like oxidized low-density lipoprotein
receptor (LOX-1) in sickle cell disease vasculopathy. Blood
Cells Mol Dis 60: 44-48, 2016.
20160005
Yokoyama C, Aoyama T, Ido T, Kakino A,
Shiraki T, Tanaka T, Nishigaki K, Hasegawa A, Fujita Y,
Sawamura T, Minatoguchi S : Deletion of LOX-1 protects
against heart failure induced by doxorubicin. PLoS One 11:
e0154994, 2016.
20160006
Yokota C, Sawamura T, Watanabe M, Kokubo
Y, Fujita Y, Kakino A, Nakai M, Toyoda K, Miyamoto Y,
Minematsu K : High levels of soluble lectin-like oxidized
low-density lipoprotein receptor-1 in acute stroke: an ageand sex-matched cross-sectional study. J Atheroscler Thromb
23: 1222-1226, 2016.
20160007
Chang CT, Wang GJ, Kuo CC, Hsieh JY, Lee
AS, Chang CM, Wang CC, Shen MY, Huang CC, Sawamura
T, Yang CY, Stancel N, Chen CH : Electronegative lowdensity lipoprotein increases coronary artery disease risk
in uremia patients on maintenance hemodialysis. Medicine(Baltimore) 95: e2265, 2016.
20160008
Hashimoto K, Mori S, Oda Y, Nakano A,
Sawamura T, Akagi M : Lectin-like oxidized low density
lipoprotein receptor 1-deficient mice show resistance toinstability-induced osteoarthritis. Scand J Rheumatol 45:
412-422, 2016.
20160009
Okamura T, Miura K, Sawamura T, Kadota
A, Hisamatsu T, Fujiyoshi A, Miyamatsu N, Takashima
N, Miyagawa N, Kadowaki T, Ohkubo T, Murakami Y,
Nakamura Y, Ueshima H, Group SR : Serum level of LOX-1
ligand containing ApoB is associated with increased carotid
intima-media thickness in Japanese community-dwellingmen, especially those with hypercholesterolemiaLOX-1
ligand and IMT in Japanese. J Clin Lipidol 10: 172-180,
2016.
20160010
Shen MY, Chen FY, Hsu JF, Fu RH, Chang CM,
Chang CT, Liu CH, Wu JR, Lee AS, Chan HC, Sheu JR, Lin
SZ, Shyu WC, Sawamura T, Chang KC, Hsu CY, Chen CH :Plasma L5 levels are elevated in ischemic stroke patients andenhance platelet aggregation. Blood 127: 1336-1345, 2016.

Molecular Cellular Physiology
20160011
Uemura T, Mori T, Kurihara T, Kawase S,
Koike R, Satoga M, Cao X, Li X, Yanagawa T, Sakurai
T, Shindo T, Tabuchi K : Fluorescent protein tagging ofendogenous protein in brain neurons using CRISPR/Cas9mediated knock-in and in utero electroporation techniques.
Sci Rep 6: 35861, 2016.
20160012
Um JW, Choii G, Park D, Kim D, Jeon S, Kang
H, Mori T, Papadopoulos T, Yoo T, Lee Y, Kim E, Tabuchi
K, Ko J : IQ Motif and SEC7 Domain-containing Protein
3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory
Synapse Formation. J Biol Chem 291(19): 10119-10130,
2016.
20160013
Ito S, Kimura S, Warabi E, Kawachi Y, Yamatoji
M, Uchida F, Ishibashi-Kanno N, Yamagata K, Hasegawa
S, Shoda J, Tabuchi K, Sakai S, Bukawa H, Sekido M,
Yanagawa T : p62 modulates the intrinsic signaling of UVBinduced apoptosis. J Dermatol Sci 83(3): 226-233, 2016.

Pathology
20160014
S h i g e m u r a T, N a k a z a w a Y, S h i m o j o H ,Kobayashi N, Agematsu K : Immune complex-mediatedglomerulonephritis in a patient with Wiskott-Aldrich
syndrome. J Clin Immunol 36: 357-359, 2016.
20160015
Yamada Y, Harada M, Yamaguchi A, Sugiyama
M, Kanno T, Hashimoto K, Ehara T, Shimojo H, Shigematsu
H, Kamijo Y : Acute phosphate nephropathy with diffuse
tubular injury despite limited calcium phosphate deposition.
Intern Med 55: 2229-2235, 2016.

4

20160016
Harada M, Kamijo Y, Nakajima T, Hashimoto
K, Yamada Y, Shimojo H, Gonzalez FJ, Aoyama T :Peroxisome proliferator-activated receptor α-dependent
renoprotection of murine kidney by irbesartan. Clin Sci(Lond) 130: 1969-1981, 2016.
20160017
Ya m a m o t o Y, O f f o r d C P, K i m u r a G ,Kuribayashi S, Takeda H, Tsuchiya S, Shimojo H, Kanno
H, Bozic I, Nowak M, Bajzer Ž, Dingli D : Tumour andimmune cell dynamics explain the PSA bounce after prostatecancer brachytherapy. Br J Cancer 115: 195-202, 2016.
20160018
Kobayashi M, Yamamoto K, Ogiwara N,
Matsumoto T, Shigeto S, Ota H. : Helicobacter heilmanniilike organism in parietal cells: A diagnostic pitfall. Pathol Int
66: 120-122, 2016.
20160019
Nakamura Y, Suzuki R, Mizuno T, Abe K,
Chiba S, Horii Y, Tsuboi J, Ito S, Obara W, Tanita T, Kanno
H, Yamauchi K : Therapeutic implication of genetic variantsof IL13 and STAT4 in airway remodelling with bronchialasthma. Clin Exp Allergy 46: 1152-1161, 2016.
20160020
Onozato T, Nakahara A, Suzuki-Kouyama E,
Hineno A, Yasude T, Nakamura T, Yahikozawa H, Watanabe
M, Kanamura K, Makishita H, Ohara S, Hashimoto T,
Higuchi K, Sakai T, Asano K, Hashimoto T, Kanno H,
Nakayama J, Oyanagi K : Axonal TDP-43 aggregates insporadic amyotrophic lateral sclerosis. Neuropathol Appl
Neurobiol 42: 561-572, 2016.

Pathobiology
20160021
Yamazaki T, Shigemura T, Kobayashi N,
Honda K, Yazaki M, Masumoto J, Migita K, Agematsu K :IL-18 serum concentration is markedly elevated in typicalfamilial Mediterranean fever with M694I mutation and candistinguish it from atypical type. Mod Rheumatol 26: 315317, 2016.

Kawahara C, Agematsu K, Yachie A, Masumoto J, Fujikawa
K, Yamasaki S, et al : Familial Mediterranean fever is nolonger a rare disease in Japan. Arthritis Res Ther 18: 175,2016.
20160025
Koga T, Migita K, Sato S, Umeda M, Nonaka F,
Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura
H, et al : Multiple Serum Cytokine Profiling to Identify
Combinational Diagnostic Biomarkers in Attacks of Familial
Mediterranean Fever. Medicine (Baltimore) 95: e3449,
2016.
20160026
I w a s a k i T, K a n e k o N , I t o Y, Ta k e d a H ,Sawasaki T, Heike T, Migita K, Agematsu K, Kawakami
A, Morikawa S, et al : Nod2-Nodosome in a CellFree System: Implications in Pathogenesis and Drug
Discovery for Blau Syndrome and Early-Onset Sarcoidosis.
ScientificWorldJournal 2016: 2597376, 2016.
20160027
Hokibara S, Kobayashi N, Kobayashi K,
Shigemura T, Nagumo H, Takizawa M, Yamazaki T,
Agematsu K : Markedly elevated CD64 expression on
neutrophils and monocytes as a biomarker for diagnosis andtherapy assessment in Kawasaki disease. Inflamm Res 65:
579-585, 2016.

Microbiology and Immunology
20160028
Funadani R, Sogame Y, Kojima K, Takeshita
T, Yamamoto K, Tsujizono T, Suizu F, Miyata S, Yagyu KI,
Suzuki T, Arikawa M, Matsuoka T : Morphogenetic andmolecular analyses of cyst wall components in the ciliatedprotozoan Colpoda cucullus Nag-1. FEMS Microbiol Lett
363(18): fnw203, 2016.

Medical Genetics

20160022
S h i g e m u r a T, N a k a z a w a Y, S h i m o j oH, Kobayashi N, Agematsu K : Complex-MediatedGlomerulonephritis in a Patient with Wiskott-Aldrich
Syndrome. J Clin Immunol 36: 357-359, 2016.

20160029
Moteki H, Azaiez H, Sloan-Heggen CM,
Booth K, Nishio SY, Wakui K, Yamaguchi T, Kolbe DL,
Iwasa YI, Shearer AE, Fukushima Y, Smith RJ, Usami SI: Detection and Confirmation of Deafness-Causing Copy
Number Variations in the STRC Gene by Massively Parallel
Sequencing and Comparative Genomic Hybridization. Ann
Otol Rhinol Laryngol 125: 918-923, 2016.

20160023
S h i g e m u r a T, K a n e k o N , K o b a y a s h i N ,Kobayashi K, Takeuchi Y, Nakano N, Masumoto J,
Agematsu K : Novel heterozygous C243Y A20/TNFAIP3
gene mutation is responsible for chronic inflammation
in autosomal-dominant Behcet's disease. RMD open 2:
e000223, 2016.

20160030
Horie S, Mochizuki T, Muto S, Hanaoka K,
Fukushima Y, Narita I, Nutahara K, Tsuchiya K, Tsuruya
K, Kamura K, Nishio S, Suwabe T, Ubara Y, Ishimura E,
Nakanishi K, Furukawa K, Kimura K, Matsuo S : Evidencebased clinical practice guidelines for polycystic kidneydisease 2014. Clin Exp Nephrol 20: 493-509, 2016.

20160024

Migita K, Izumi Y, Jiuchi Y, Iwanaga N,

20160031

N a k a s h i m a M , Ta k a n o K , Ts u y u s a k i Y,

5

Yoshitomi S, Shimono M, Aoki Y, Kato M, Aida N,
Mizuguchi T, Miyatake S, Miyake N, Osaka H, Saitsu H,
Matsumoto N : WDR45 mutations in three male patientswith West syndrome. J Hum Genet 61: 653-661, 2016.

: Occupational exposure limits of lead, dimethylamine,
n-butyl-2,3-epoxypropyl ether, and 2-ethyl-1-hexanol andcarcinogenicity and occupational sensitizer classification. J
Occup Health 58(4 spec iss): 385-387, 2016.

20160032
Takano K, Shiba N, Wakui K, Yamaguchi
T, Aida N, Inaba Y, Fukushima Y, Kosho T : Elevationof neuron specific enolase and brain iron deposition on
susceptibility-weighted imaging as diagnostic clues forbeta-propeller protein-associated neurodegeneration inearly childhood: Additional case report and review of theliterature. Am J Med Genet A 170A: 322-328, 2016.

Legal Medicine

Preventive Medicine and Public Health20160033
Tsukahara T, Arai H, Kamijo T, Kobayashi Y,
Washizuka S, Arito H, Nomiyama T : Relationships between
suicidal ideation and psychosocial factors among residents
living in Nagano Prefecture of Japan. Environ Health Prev
Med 21(3): 164-172, 2016.
20160034
Tsukahara T, Miyauchi H, Kuwada d, Kikuchi
T, Tsuda Y, Yanagiba Y, Arito H, Nomiyama T : Control
banding assesment of exposure of offset printing workers toorganic solvents. J Occup Health 58(3): 314-319, 2016.
20160035
Hyakutake A, Kamijo T, Misawa Y, Washizuka
S, Inaba Y, Tsukahara T, Nomiyama T : Cross-sectional
observation of the relationship of depressive symptoms withlifestyles and parents' status among Japanese junior highschool students. Environ Health Prev Med 21(4): 265-273,
2016.
20160036
Tsuda Y, Otsuka T, Tsukahara T, Nomiyama T :Measurement of fluoride in human urine by headspace gas
chromatography-mass spectrometer. Biomedical research on
trace elements 27(1): 15-22, 2016.
20160037
Tsukahara T, Arai H, Kamijo T, Kobayashi
Y, Washizuka S, Arito H, Nomiyama T : The relationshipbetween attitudes toward suicide and family history ofsuicide in Nagano Prefecture, Japan. Int J Environ Res
Public Health 13(6): E623, 2016.
20160038
The committee for recommendationof occupational exposure limits, Japan Society for
Occupational Health; Azuma K, Endo G, Endo Y, Hara K,
HaradaK, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara
G, Ikeda M, Ishitake G, Ito A, Iwasawa S, Kamijima M,
Karita K, Nasu T, Nomiyama T, Omae K, Sato K, Okuda
H, Sakurai H, Sobue T, Suwazono Y, Takebayashi T,
Takeshita T, Takeuchi A, Tanaka M, Tanaka S, Tsukahara
T, Tsunoda M, Ueno S, Yamano Y, Yamauchi T, Yano E

20160039
Nunotani M, Sato N, Kamei S, Shiozaki T,
Hayashi T, Asamura H : Development of Multiple Assays
using 46 SNPs for Comprehensive mtDNA Haplogrouping
and Application to Highly Degraded DNA. J Forensic Sci
61: 472-477, 2016.
20160040
Hirayama A, Joshita S, Kitahara K, Mukawa
K, Suga T, Umemura T, Tanaka E, Ota M : Lymphocyte
Antigen 75 Polymorphisms Are Associated with Disease
Susceptibility and Phenotype in Japanese Patients with
Inflammatory Bowel Disease. Dis Markers 2016: 6485343,
2016.
20160041
Carapito R, Jung N, Kwemou M, Untrau
M, Michel S, Pichot A, Giacometti G, Macquin C, Ilias
W, Morlon A, Kotova I, Apostolova P, Schmitt-Graeff
A, Cesbron A, Gagne K, Oudshoorn M, van der Holt B,
Labalette M, Spierings E, Picard C, Loiseau P, Tamouza
R, Toubert A, Parissiadis A, Dubois V, Lafarge X, MaumyBertrand M, Bertrand F, Vago L, Ciceri F, Paillard C,
Querol S, Sierra J, Fleischhauer K, Nagler A, Labopin M,
Inoko H, von dem Borne PA, Kuball J, Ota M, Katsuyama
Y, Michallet M, Lioure B, Peffault de Latour R, Blaise D,
Cornelissen JJ, Yakoub-Agha I, Claas F, Moreau P, Milpied
N, Charron D, Mohty M, Zeiser R, Socié G, Bahram S: Matching for the nonconventional MHC-I MICA genesignificantly reduces the incidence of acute and chronic
GVHD. Blood 128: 1979-1986, 2016.
20160042
Umemura T, Joshita S, Yamazaki T, Komatsu
M, Katsuyama Y, Yoshizawa K, Tanaka E, Ota M : Genetic
Association of PTPN22 Polymorphisms with Autoimmune
Hepatitis and Primary Biliary Cholangitis in Japan. Sci Rep
6: 29770, 2016.
20160043
Yo s h i z a w a K , J o s h i t a S , M a t s u m o t o A ,Umemura T, Tanaka E, Morita S, Maejima T, Ota M :Incidence and prevalence of autoimmune hepatitis in the
Ueda area, Japan. Hepatol Res 46: 878-883, 2016.
20160044
Nishisako M, Meguro A, Nomura E, Yamane
T, Takeuchi M, Ota M, Kashiwagi K, Mabuchi F, Iijima
H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara
T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M,
Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T,
Kiuchi Y, Iwase A, Chin S, Ohno S, Inoko H, Mizuki N :6

SLC1A1 Gene Variants and Normal Tension Glaucoma: An
Association Study. Ophthalmic Genet 37: 194-200, 2016.

Internal Medicine 1

pulmonarylesions: A retrospective study of 240 examinations
in a single academic center. Respir Investig 54: 347-354,
2016.

20160045
Matsui S, Yamamoto H, Minamoto S, Waseda
Y, Mishima M, Kubo K : Proposed diagnostic criteria for
IgG4-related respiratory disease. Respir Investig 54: 130132, 2016.

20160052
Kato A, Yamamoto H, Ikeda M, Tateishi
K, Ushiki A, Yasuo M, Kawakami S, Asaka S, Oguchi
K, Hanaoka M : A case of pulmonary Mycobacterium avium
infection in an immunocompetent patient who showed ahuge consolidation with a high FDG uptake on PET/CT.
Respir Med Case Rep 19: 49-52, 2016.

20160046
Masaki Y, Kawabata H, Takai K, Kojima
M, Tsukamoto N, Ishigaki Y, Kurose N, Ide M, Murakami
J, Nara K, Yamamoto H, Ozawa Y, Takahashi H, Miura
K, Miyauchi T, Yoshida S, Momoi A, Awano N, Ikushima
S, Ohta Y, Furuta N, Fujimoto S, Kawanami H, Sakai
T, Kawanami T, Fujita Y, Fukushima T, Nakamura
S, Kinoshita T, Aoki S : Proposed diagnostic criteria, disease
severity classification and treatment strategy for TAFRO
syndrome, 2015 version. Int J Hematol 103: 686-692, 2016.

20160053
Yamauchi H, Bando M, Baba T, Kataoka K,
Yamada Y, Yamamoto H, Miyamoto A, Ikushima S, Johkoh
T, Sakai F, Terasaki Y, Hebisawa A, Kawabata Y, Sugiyama
Y, Ogura T : Clinical Course and Changes in HighResolution Computed Tomography Findings in Patientswith Idiopathic Pulmonary Fibrosis without Honeycombing.
PLoS One 11: e0166168, 2016.

20160047
K i t a g u c h i Y, Ya s u o M , H a n a o k a M :Comparison of pulmonary function in patients with COPD,
asthma-COPD overlap syndrome, and asthma with airflow
limitation. Int J Chron Obstruct Pulmon Dis 11: 991-997,
2016.

20160054
Wada Y, Koyama S, Kuraishi H, Miyahara
T, Yoshiike F, Agatsuma T, Yamamoto R, Ono Y, Suzuki
T, Hachiya T, Gomi D, Tateishi K, Hanaoka M, Koizumi
T : Clinical analysis of patients treated with afatinib foradvanced non-small cell lung cancer: A Nagano Lung
Cancer Research Group observational study. Respir Investig
54: 462-467, 2016.

20160048
Hayashida M, Yasuo M, Hanaoka M, Seyama
K , I n o u e Y, Ta t s u m i K , M i s h i m a M ; R e s p i r a t o r yFailure Research Group of the Ministry of Health, Labour,and Welfare, Japan : Reductions in pulmonary function
detected in patients with lymphangioleiomyomatosis: An
analysis of the Japanese National Research Project on
Intractable Diseases database. Respir Investig 54: 193-200,
2016.
20160049
Hama M, Ushiki A, Kosaka M, Yamazaki
Y, Yasuo M, Yamamoto H, Hanaoka M : Health-related
quality of life in patients with pulmonary non-tuberculous
mycobacteria infection. Int J Tuberc Lung Dis 20: 747-752,
2016.
20160050
Yasuo M, Kobayashi T, Hama M, Ichiyama
T, Horiuchi T, Yamamoto H, Kawakami S, Hamanaka
K, Honda T, Hanaoka M : Combination of virtual
bronchoscopic navigation with conventional transbronchialneedleaspiration in the diagnosis of peribronchial pulmonary
lesions located in the middle third of the lungs. Respir
Investig 54: 355-363, 2016.
20160051
Tokoro Y, Yasuo M, Kobayashi T, Hama
M , I c h i y a m a T, H o r i u c h i T, U s h i k i A , K a w a k a m i
S, Honda T, Hanaoka M : Computed tomographyguided bronchoscopy in the diagnosis of small peripheral

20160055
Takada T, Mikami A, Kitamura N, Seyama
K, Inoue Y, Nagai K, Suzuki M, Moriyama H, Akasaka
K, Tazawa R, Hirai T, Mishima M, Hayashida M, Hirose
M, Sugimoto C, Arai T, Hattori N, Watanabe K, Tamada
T, Yoshizawa H, Akazawa K, Tanaka T, Yagi K, Young
LR, McCormack FX, Nakata K : Efficacy and Safety ofLong-Term Sirolimus Therapy for Asian Patients with
Lymphangioleiomyomatosis. Ann Am Thorac Soc 13: 19121922, 2016.

Internal Medicine 2
20160056
Akamatsu T, Uehara H, Okamura T, Iwaya Y,
Suga T : Screening and Treatment for Helicobacter pylori
Infection in Teenagers in Japan. J Gastrointest Dig Syst 6:
1000454, 2016.
20160057
Fujimori N, Tanaka N, Shibata S, Sano K,
Yamazaki T, Sekiguchi T, Kitabatake H, Ichikawa Y, Kimura
T, Komatsu M, Umemura T, Matsumoto A, Tanaka E :Controlled attenuation parameter is correlated with actual
hepatic fat content in patients with non-alcoholic fatty liverdisease with none-to-mild obesity and liver fibrosis. Hepatol
Res 46: 1019-1027, 2016.
20160058

Harada M, Kamijo Y, Nakajima T, Hashimoto

7

K, Yamada Y, Shimojo H, Gonzalez FJ, Aoyama T :Peroxisome proliferator-activated receptor alpha-dependent
renoprotection of murine kidney by irbesartan. Clin Sci(Lond) 130: 1969-1981, 2016.

20160067
Shibata S, Umemura T, Yamazaki T, Fujimori
N, Ichikawa Y, Kimura T, Joshita S, Komatsu M, Matsumoto
A, Tanaka E : Liver stiffness-spleen size-to-platelet ratio risk
score identifies esophageal varices in Japanese patients withchronic hepatitis C. Hepatol Res 46: 884-889, 2016.

20160059
Harada M, Tsukada W, Tsukada O, Hashimoto
K, Kamijo Y : The Optimal Cut-off Value of Ankle Brachial
Index for Screening Cardiovascular Disease Risk in
Hemodialysis Patients. Shinshu Medical Journal 64: 135146, 2016.

20160068
Suga T, Okamura T, Arakura N, Tanaka E :The loop-forming method as a useful technique to rotate
the endoscopic insertion tube shaft. Endosc Int Open 4:
E170-E174, 2016.

20160060
Hashimoto K, Harada M, Kamijo Y : Pure redcell aplasia induced by anti-erythropoietin antibodies, wellcontrolled with tacrolimus. Int J Hematol 104: 502-505,
2016.

20160069
Suga T, Okamura T, Iwaya Y, Ito T, Arakura N,
Umemura T, Tanaka E : A Case of Esophageal Hemangioma
Successfully Treated by Endoscopic Injection Sclerotherapy.
Shinshu Medical Journal 64: 75-78, 2016.

20160061
Hirayama A, Joshita S, Kitahara K, Mukawa
K, Suga T, Umemura T, Tanaka E, Ota M : Lymphocyte
Antigen 75 Polymorphisms Are Associated with Disease
Susceptibility and Phenotype in Japanese Patients with
Inflammatory Bowel Disease. Dis Markers 2016: 6485343,
2016.

20160070
Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka
N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K,
Gonzalez FJ, Aoyama T : Age-dependent PPARalphaactivation induces hepatic sulfatide accumulation intransgenic mice carrying the hepatitis C virus core gene.
Glycoconj J 33: 927-936, 2016.

20160062
Iwaya Y, Yamazaki T, Watanabe T, Seki A,
Ochi Y, Hara E, Arakura N, Tanaka E, Hasebe O : Caseof Barrett's adenocarcinoma with marked endoscopic
morphological changes in Barrett's esophagus over a long
follow-up period of 15 years. Dig Endosc 28: 607-610,
2016.

20160071
Umemura T, Joshita S, Yamazaki T, Komatsu
M, Katsuyama Y, Yoshizawa K, Tanaka E, Ota M : Genetic
Association of PTPN22 Polymorphisms with Autoimmune
Hepatitis and Primary Biliary Cholangitis in Japan. Sci Rep
6: 29770, 2016.

20160063
Kanai K, Maruyama M, Kameko F, Kawasaki
K, Asano J, Oguchi T, Watanabe T, Ito T, Muraki T, Hamano
H, Matsumoto A, Arakura N, Kawa S : Autoimmune
Pancreatitis Can Transform Into Chronic Features Similar
to Advanced Chronic Pancreatitis With Functional
Insufficiency Following Severe Calcification. Pancreas 45:
1189-1195, 2016.
20160064
Kiniwa Y, Matoba H, Hamano H, Senoo Y,
Okuyama R : Cutaneous plasmacytosis associated with
autoimmune hemolytic anemia. J Dermatol 43: 343-345,
2016.
20160065
Mori K, Matsumoto A, Maki N, Ichikawa Y,
Tanaka E, Yagi S : Production of infectious HCV genotype
1b virus in cell culture using a novel Set of adaptive
mutations. BMC Microbiol 16: 224, 2016.
20160066
Shibata S, Umemura T, Komatsu M, Tanaka
E : Severe hepatotoxicity associated with asunaprevir anddaclatasvir in chronic hepatitis C. Hepatology 63: 20632064, 2016.

20160072
Umeshita K, Inomata Y, Furukawa H, Kasahara
M, Kawasaki S, Kobayashi E, Kokudo N, Sakisaka S,
Shimada M, Tanaka E, Uemoto S, for the Japanese Liver
Transplantation Society : Liver transplantation in Japan:
Registry by the Japanese Liver Transplantation Society.
Hepatol Res 46: 1171-1186, 2016.
20160073
Yamada Y, Harada M, Yamaguchi A, Sugiyama
M, Kanno T, Hashimoto K, Ehara T, Shimojo H, Shigematsu
H, Kamijo Y : Acute Phosphate Nephropathy with Diffuse
Tubular Injury Despite Limited Calcium Phosphate
Deposition. Intern Med 55: 2229-2235, 2016.
20160074
Yamazaki T, Iwaya Y, Iwaya M, Watanabe T,
Seki A, Ochi Y, Hara E, Sekiguchi T, Hosaka N, Arakura N,
Tanaka E, Hasebe O : A case of simultaneous esophageal
squamous cell carcinoma and Barrett's adenocarcinoma. Clin
J Gastroenterol 9: 222-227, 2016.
20160075
Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka
N, Sugiyama E, Kamijo Y, Aoyama T : Activation of
PPARalpha by Fatty Acid Accumulation Enhances Fatty
Acid Degradation and Sulfatide Synthesis. Tohoku J Exp
Med 240: 113-122, 2016.

8

20160076
Yo s h i z a w a K , J o s h i t a S , M a t s u m o t o A ,Umemura T, Tanaka E, Morita S, Maejima T, Ota M :Incidence and prevalence of autoimmune hepatitis in the
Ueda area, Japan. Hepatol Res 46: 878-883, 2016.

Internal Medicine 3

20160085
Minamisawa M, Koyama J, Sekijima Y, Ikeda
S, Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A,
Izawa A, Ikeda U : Comparison of the standard and speckle
tracking echocardiographic features of wild-type andmutated transthyretin cardiac amyloidoses. Eur Heart J
Cardiovasc Imaging 17: 402-410, 2016.

20160077
Abe R, Kinoshita T, Hineno A, Ikeda S :Monoarthropathy or polyarthritis in adolescent japanese girls
who received immunization with the human papillomavirus
vaccine. Case Rep Clin Med 5: 109-114, 2016.

20160086
Miyazaki D, Fukushima K, Nakahara A,
Kodaira M, Mochizuki K, Kaneko K, Kaneko T, Sekijima Y,
Ikeda S : Crossed cerebellar diaschisis in status epilepticus.
Intern Med 55: 1649-1651, 2016.

20160078
Abe R, Sekijima Y, Kinoshita T, Yoshinaga T,
Koyama S, Kato T, Ikeda SI : Spinal form cerebrotendinous
xanthomatosis patient with long spinal cord lesion. J Spinal
Cord Med 39: 726-729, 2016.

20160087
Miyazaki D, Nakamura A, Hineno A, Kobayashi
C, Kinoshita T, Yoshida K, Ikeda S : Elevation of serum
heat-shock protein levels in amyotrophic lateral clerosis.
Neurol Sci 37: 1277-1281, 2016.

20160079
Ando Y, Sekijima Y, Obayashi K, Yamashita T,
Ueda M, Misumi Y, Morita H, Machii K, Ohta M, Takata
A, Ikeda S : Effects of tafamidis treatment on transthyretin(TTR) stabilization, efficacy, and safety in Japanese patientswith familial amyloid polyneuropathy (TTR-FAP) with
Val30Met and non-Varl30Met: A phase III, open-label study.
J Neurol Sci 362: 266-271, 2016.

20160088
Nakagawa M, Sekijima Y, Yazaki M, Tojo K,
Yoshinaga T, Doden T, Koyama J, Yanagisawa S, Ikeda S: Carpal tunnel syndrome: a common initial symptom ofsystemic wild-type ATTR (ATTRwt) amyloidosis. Amyloid
23: 58-63, 2016.

20160080
Fujita T, Ichikawa S, Okitsu Y, Fukuhara
N, Yoshinaga T, Yazaki M, Harigae H : Primary AL
amyloidosis presenting with systemic lymphadenopathy withcalcification. Int J Hematol 104: 641-643, 2016.
20160081
Hamanoue S, Suwabe T, Hoshino J, Sumida
K, Mise K, Hayami N, Sawa N, Takaichi K, Fujii T, Ohashi
K, Yazaki M, Ikeda S, Ubara Y : Successful treatment
with humanized anti-interleukin-6 receptor antibody(tocilizumab) in a case of AA amyloidosis complicated byfamilial Mediterranean fever. Mod Rheumatol 26: 610-613,
2016.
20160082
Imamura M, Nakamura A, Mannen H, Takeda
S : Characterization of WWP1 protein expression in skeletal
muscle of muscular dystrophy chickens. J Biochem 159:
171-179, 2016.
20160083
Kobayashi C, Miyazaki D, Kinoshita T, Hineno
A, Nakamura A : Increasing incidence and age at onset of
amyotrophic lateral sclerosis in Nagano prefecture, Japan.
Shinshu Medical Journal 64: 239-246, 2016.
20160084
Kobayashi Y, Sekijima Y, Ogawa Y, Kondo Y,
Miyazaki D, Ikeda SI : Extremely early onset hereditary
ATTR amyloidosis with G47R (p.G67R) mutation. Amyloid
23: 205-206, 2016.

20160089
Nakamura A, Fueki N, Shiba N, Motoki
H, Miyazaki D, Nishizawa H, Echigoya Y, Yokota T,
Aoki Y, Takeda S : Deletion of exons 3-9 encompassing
a mutational hot spot in the DMD gene presents an
asymptomatic phenotype, indicating a target region for
multiexon skipping therapy. J Hum Genet 61: 663-667,
2016.
20160090
Nakamura A, Shiba N, Miyazaki D, Nishizawa
H, Inaba Y, Fueki N, Maruyama R, Echigoya Y, Yokota
T : Comparison of the phenotypes of patients harboring
in-frame deletions starting at exon 45 in the Duchenne
muscular dystrophy gene indicates potential for thedevelopment of exon skipping therapy. J Hum Genet 62:
459-463, 2016.
20160091
Nishizawa H, Shiba N, Nakamura A :Usefulness of continuous actigraph monitoring in theassessment of the effect of corticosteroid treatment for
Duchenne muscular dystrophy: a case report. J Phys Ther
Sci 28: 3249-3251, 2016.
20160092
Oyanagi K, Yamada M, Hineno A, Yahikozawa
H, Ushiyama M, Miki J, Kanno H, Nakayama J, Makishita
H, Inoue K, Ohara S, Hayashida K, Kayanuma K,
Yamamoto K, Yasude T, Hashimoto T, Yoshida K, Ikeda SI :Shinshu Brain Resource Net. Neuropathology 36: 600-601,
2016.
20160093

Onozato T, Nakahara A, Suzuki-Kouyama E,

9Hineno A, Yasude T, Nakamura T, Yahikozawa H, Watanabe
M, Kayanuma K, Makishita H, Ohara S, Hashimoto T,
Higuchi K, Sakai T, Asano K, Hashimoto T, Kanno H,
Nakayama J, Oyanagi K : Axonal TDP-43 aggregates insporadic amyotrophic lateral sclerosis. Neuropathol Appl
Neurobiol 42: 561-572, 2016.

20160102
Yoshinaga T, Yazaki M, Sekijima Y, Kametani
F, Miyashita K, Hachiya N, Tanaka T, Kokudo N, Higuchi
K, Ikeda S : The pathological and biochemical identificationof possible seed-lesions of transmitted transthyretin
amyloidosis after domino liver transplantation. J Pathol Clin
Res 2: 72-79, 2016.

20160094
Sekijima Y, Yazaki M, Oguchi K, Ezawa N,
Yoshinaga T, Yamada M, Yahikozawa H, Watanabe M,
Kametani F, Ikeda S : Cerebral amyloid angiopathy inposttransplant patients with hereditary ATTR amyloidosis.
Neurology 87: 773-781, 2016.

Internal Medicine 4

20160095
Shirai T, Sano T, Kamijo F, Saito N, Miyake
T, Kodaira M, Katoh N, Nishie K, Okuyama R, Uhara
H : Acetylcholine receptor binding antibody-associatedmyasthenia gravis and rhabdomyolysis induced bynivolumab in a patient with melanoma. Jpn J Clin Oncol 46:
86-88, 2016.

20160103
Seino H, Onishi Y, Naito Y, Komatsu M :Lixisenatide improves glycemic outcomes of Japanesepatients with type 2 diabetes: a meta-analysis. Diabetol
Metab Syndr 8: 36, 2016.
20160104
Okubo Y, Sato Y, Nakasone Y, Shirotori K,
Oguchi K, Matsushita T, Nishikawa T, Yamazaki Y, Sasano
H, Komatsu M, Yamauchi K, Aizawa T : Extraordinarily
high aldosterone, 901.0 ng/dL, in a patient with primaryaldosteronism: an insight into the underlying mechanism.
Endocr J 63(2): 127-133, 2016.

20160096
Tachibana N, Ishii K, Ikeda S : Cerebral
amyloid angiopathy-related microbleeds: radiology versus
pathology. Intern Med 55: 1235-1236, 2016.
20160097
Ueno A, Katoh N, Aramaki O, Makuuchi M,
Ikeda S : Liver transplantation is a potential treatment option
for systemic light chain amyloidosis patients with dominant
hepatic involvement: a case report and analytical review ofthe literature. Intern Med 55: 1585-1590, 2016.
20160098
Ueno KI, Shimojima Y, Kishida D, Sekijima
Y, Ikeda S : Advantage of administering tacrolimus for
improving prognosis of patients with polymyositis anddermatomyositis. Int J Rheum Dis 19: 1322-1330, 2016.
20160099
Ushiyama S, Kinoshita T, Shimojima Y,
Kishida D, Miyazaki D, Nakamura K, Sekijima Y, Ikeda SI: Hypertrophic Pachymeningitis as an Early Manifestationof Relapsing Polychondritis: Case Report and Review of the
Literature. Case Rep Neurol 8: 211-217, 2016.
20160100
Wen Z, Shimojima Y, Shirai T, Li Y, Ju J, Yang
Z, Tian L, Goronzy JJ, Weyand CM : NADPH oxidase
deficiency underlies dysfunction of aged CD8+ Tregs. J Clin
Invest 126: 1953-1967, 2016.
20160101
Yamazaki T, Shigemura T, Kobayashi N,
Honda K, Yazaki M, Masumoto J, Migita K, Agematsu K :IL-18 serum concentration is markedly elevated in typicalfamilial Mediterranean fever with M694I mutation and candistinguish it from atypical type. Mod Rheumatol 26: 315317, 2016.

Internal Medicine 5
20160105
Okada A, Kashima Y, Tomita T, Takeuchi
T, Aizawa K, Takahashi M, Ikeda U : Characterizationof cardiac oxidative stress levels in patients with atrial
fibrillation. Heart Vessels 31: 80-87, 2016.
20160106
Kimura K, Momose T, Hasegawa T, Morita
T, Misawa T, Motoki H, Izawa A, Ikeda U : Earlyadministration of tolvaptan preserves renal function inelderly patients with acute decompensated heart failure. J
Cardiol 67: 399-405, 2016.
20160107
Hioki H, Miura T, Miyashita Y, Ebisawa
S, Motoki H, Izawa A, Koyama J, Ikeda U, on behalfof the SHINANO registry investigators : Circulating
eicosapentaenoic acid to oleic acid ratio and risk for
cardiovascular events in patients with coronary arterydisease: A sub-analysis of the SHINANO registry. IJC Metab
Endocr 10: 1-6, 2016.
20160108
Ueki Y, Miura T, Miyashita Y, Motoki H,
Shimada K, Kobayashi M, Nakajima H, Kimura H,
Akanuma H, Mawatari E, Sato T, Hotta S, Kamiyoshi Y,
Maruyama T, Watanabe N, Eisawa T, Aso S, Uchikawa S,
Hashizume N, Sekimura N, Morita T, Ebisawa S, Izawa
A, Koyama J, Ikeda U : Predictive Value of Combining theAnkle-Brachial Index and SYNTAX Score for the Predictionof Outcome After Percutaneous Coronary Intervention (fromthe SHINANO Registry). Am J Cardiol 117: 179-185, 2016.
20160109

Hioki H, Miyashita Y, Shiraki T, Iida O,

10

Uematsu M, Miura T, Ebisawa S, Ikeda U : Impact ofdeteriorated calcium-phosphate homeostasis on amputationfree survival after endovascular revascularization in patientswith critical limb ischemia on hemodialysis. Vasc Med 21:
137-143, 2016.
20160110
Hioki H, Motoki H, Izawa A, Kashima Y, MiuraT, Ebisawa S, Tomita T, Miyashita Y, Koyama J, Ikeda U: Impact of oral beta-blocker therapy on mortality after
primary percutaneous coronary intervention for Killip class
1 myocardial infarction. Heart Vessels 31: 687-693, 2016.
20160111
Minamisawa M, Motoki H, Izawa A, Kashima
Y, Hioki H, Abe N, Miura T, Ebisawa S, Miyashita
Y, Koyama J, Ikeda U : Comparison of Inflammatory
Biomarkers in Outpatients With Prior Myocardial Infarction.
Int Heart J 57: 11-17, 2016.
20160112
Minamisawa M, Koyama J, Kozuka A,
Miura T, Ebisawa S, Motoki H, Okada A, Izawa A, Ikeda
U : Regression of left ventricular hypertrabeculation isassociated with improvement in systolic function andfavorable prognosis in adult patients with non-ischemic
cardiomyopathy. J Cardiol 68: 431-438, 2016.

20160118
Nakamura A, Fueki N, Shiba N, Motoki H,
Miyazaki D, Nishizawa H, Echigoya Y, Yokota T, Aoki Y,
Takeda S : Deletion of exons 3-9 encompassing a mutational
hot spot in the DMD gene presents an asymptomatic
phenotype, indicating a target region for multiexon skipping
therapy. J Hum Genet 61: 663-667, 2016.
20160119
Koyama J : Prognostic Significance of Occult
Transthyretin Cardiac Amyloidosis in Patients With
Severe Aortic Stenosis Undergoing Surgical Aortic Valve
Replacement: An Unrecognized Disease Modifier. Circ
Cardiovasc Imaging 9: e005320, 2016.
20160120
Shiba Y, Gomibuchi T, Seto T, Wada Y,
Ichimura H, Tanaka Y, Ogasawara T, Okada K, Shiba N,
Sakamoto K, Ido D, Shiina T, Ohkura M, Nakai J, Uno N,
Kazuki Y, Oshimura M, Minami I, Ikeda U : Allogeneictransplantation of iPS cell-derived cardiomyocytes
regenerates primate hearts. Nature 538: 388-391, 2016.

20160113
Minamisawa M, Koyama J, Ikeda U : Author's
reply. J Cardiol 68: 359-360, 2016.

20160121
Nishimura H, Miura T, Minamisawa M, Ueki
Y, Abe N, Hashizume N, Mochidome T, Harada M, Shimizu
K, Shoin W, Yoshie K, Oguchi Y, Ebisawa S, Motoki
H, Izawa A, Koyama J, Ikeda U, Kuwahara K : Clinical
Characteristics and Outcomes of Patients with High AnkleBrachial Index from the IMPACT-ABI Study. PLoS One 11:
e0167150, 2016.

20160114
Minamisawa M, Koyama J, Sekijima Y, Ikeda
S, Kozuka A, Ebisawa S, Miura T, Motoki H, Okada A,
Izawa A, Ikeda U : Comparison of the standard and speckle
tracking echocardiographic features of wild-type andmutated transthyretin cardiac amyloidoses. Eur Heart J
Cardiovasc Imaging 17: 402-410, 2016.

20160122
Nakajima H, Yoshioka J, Totsuka N, Miyazawa
I, Usui T, Urasawa N, Kobayashi T, Mochidome T :Activities of daily living as an additional predictor ofcomplications and outcomes in elderly patients with acute
myocardial infarction. Clin Interv Aging 11: 1141-1147,
2016.

20160115
U e k i Y, M o h r i M , M a t o b a T, Ts u j i t a Y,
Yamasaki M, Tachibana E, Yonemoto N, Nagao K :Characteristics and Predictors of Mortality in Patients With
Cardiovascular Shock in Japan – Results From the Japanese
Circulation Society Cardiovascular Shock Registry –. Circ J
80: 852-859, 2016.

20160123
Numaga-Tomita T, Kitajima N, Kuroda T,
Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide
T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M : TRPC3GEF-H1 axis mediates pressure overload-induced cardiac
fibrosis. Sci Rep 6: 39383, 2016.

20160116
H a s e g a w a T, Ta b a t a H , K a g o s h i m a M ,Okada H, Aida H, Shoin W, Shoin K, Ikada U : A case of
pregnancy-associated acute myocardial infarction withrefractory ventricular fibrillation and heart failure. J Cardiol
Cases 14: 13-16, 2016.
20160117
Nakagawa M, Sekijima Y, Yazaki M, Tojo K,
Yoshinaga T, Doden T, Koyama J, Yanagisawa S, Ikeda S: Carpal tunnel syndrome: a common initial symptom ofsystemic wild-type ATTR (ATTRwt) amyloidosis. Amyloid
23: 58-63, 2016.

Psychiatry
20160124
Hori H, Sasayama D, Teraishi T, Yamamoto
N, Nakamura S, Ota M, Hattori K, Kim Y, Higuchi
T, Kunugi H : Blood-based gene expression signatures of
medication-free outpatients with major depressive disorder:
integrative genome-wide and candidate gene analyses. Sci
Rep 6: 18776, 2016.
20160125
Hyakutake A, Kamijo T, Misawa Y, Washizuka
S, Inaba Y, Tsukahara T, Nomiyama T : Cross-sectional
observation of the relationship of depressive symptoms with

11

lifestyles and parents' status among Japanese junior highschool students. Environ Health Prev Med 21: 265-273,
2016.
20160126
Joko T, Washizuka S, Sasayama D, Inuzuka
S, Ogihara T, Kaneko T, Hanihara T, Amano N : Patternsof hippocampal atrophy differ among Alzhheimer's
disease, amnestic mild congnitive impairment, and late-life
depression. Psychogeriatrics 16: 355-361, 2016.
20160127
Kobayashi M, Sugiyama N, Sasayama D,
Sasamoto H, Miyashiro Y, Arima K, Washizuka S : Sex
differences in the serum level of endogenous ligands for
estrogen receptor β in the elderly population. Sci Rep 6:25878, 2016.
20160128
Miyashita M, Watanabe T, Ichikawa T, Toriumi
K, Horiuchi Y, Kushima I, Hashimoto R, Fukumoto M,
Koike S, Ujike H, Arinami T, Tatebayashi Y, Kasai K,
Takeda M, Ozaki Y, Yoshikawa T, Amano N, Washizuka S,
Yamamoto H, Miyata T, Itokawa M, Yamamoto Y, Arai M: The regulation of soluble recepter for AGEs contributes
to carbpnylstress in schizophrenia. Biochem Biophys Res
Commun 479: 447-452, 2016.
20160129
Mutai H, Furukawa T, Nakanishi K, Hanihara
T : Longitudinal functional changes, depression, and healthrelated quality of life among stroke survivors living at home
after inpatient rehabilitation. Psychogeriatrics 16: 185-190,
2016.
20160130
Nakamura T, Setsu K, Takahashi T, Miyashita
M, Sugiyama N, Washizuka S, Murata S, Hanihara
T, Amano N : Chronic exposure to carbon monoxide in
two elderly patients using a kotatsu, a traditional Japanesecharcoal-based heater. Psychogeriatrics 16: 323-326, 2016.
20160131
Nakanishi K, Mutai H, Hanihara T : Change inquality of life of people with dementia in residential carefacilities: a 3-year follow-up study. Psychogeriatrics 16:
336-338, 2016.
20160132
S a s a y a m a D , Wa s h i z u k a S , H o n d a H :Effective Treatment of Night Terrors and Sleepwalking with
Ramelteon. J Child Adolesc Psychopharmacol 26: 948,
2016.
20160133
Tsukahara T, Arai H, Kamijo T, Kobayashi
Y, Washizuka S, Arito H, Nomiyama T : Relationships
between suicidal ideation and psychosocial factors amongresidents living in Nagano Prefecture of Japan. Environ
Health Prev Med 21: 164-172, 2016.

20160134
Tsukahara T,Arai H, Kamijo T, KobayashiY,
Washizuka S, Arito H, Nomiyama T : The Relationshipbetween Attitudes toward Suicide and Family History of
Suicide in Nagano Prefecture, Japan. Int J Environ Res
Public Health 13: 623, 2016.

Pediatrics
20160135
Nakazawa Y, Matsuda K, Kurata T, Sueki A,
Tanaka M, Sakashita K, Imai C, Wilson MH, Koike K :Anti-proliferative effects of T cells expressing a ligandbased chimeric antigen receptor against CD116 on CD34(+)
cells of juvenile myelomonocytic leukemia. J Hematol
Oncol 9: 27, 2016.
20160136
Morita D, Nakazawa Y, Tanaka M, Nakayama Y,
Koizumi T, Koike K : Early-onset colorectal cancer in young
adult survivors of childhood cancer. Pediatr Int 58: 637-639,
2016.
20160137
Shigemura T, Nishina S, Nakazawa H, Matsuda
K, Yaguchi T, Nakazawa Y : Early detection of Rhizopus
DNA in the serum of a patient with rhino-orbital-cerebral
mucormycosis following allogeneic hematopoietic stem celltransplantation. Int J Hematol 103: 354-355, 2016.
20160138
S h i g e m u r a T, N a k a z a w a Y, S h i m o j o H ,Kobayashi N, Agematsu K : Immune Complex-MediatedGlomerulonephritis in a Patient with Wiskott-Aldrich
Syndrome. J Clin Immunol 36: 357-359, 2016.
20160139
S h i g e m u r a T, K a n e k o N , K o b a y a s h i N ,Kobayashi K, Takeuchi Y, Nakano N, Masumoto J,
Agematsu K : Novel heterozygous C243Y A20/TNFAIP3
gene mutation is responsible for chronic inflammation
in autosomal-dominant Behçet's disease. RMD Open 2:
e0000223, 2016.
20160140
Motoki N, Inaba Y, Matsuzaki S, Akazawa Y,
Nishimura T, Fukuyama T, Koike K : Successful treatmentof arrhythmia-induced cardiomyopathy in an infant withtuberous sclerosis complex. BMC Pediatr 16: 16, 2016.
20160141
Motobayashi M, Nishimura T, Inaba Y :Usefulness of Circulating B-cell-Activating Factor Serial
Monitoring in Childhood-Onset Ocular Myasthenia Gravis.
Pediatr Neurol 63: e1-e2, 2016.
20160142
Motobayashi M, Morita D, Kurata T, Shigemura
T, Nakazawa Y, Shimozawa N, Inaba Y : Serial Monitoringof Plasma Levetiracetam Levels in a Child With Epilepsy
Undergoing Cord Blood Transplantation. Pediatr Neurol 64:
e5-e6, 2016.

12

20160143
Morita D, Hirabayashi K, Katsuyama Y,
Morokawa H, Motobayashi M, Kurata T, Shigemura T,
Tanaka M, Inaba Y, Koike K, Nakazawa Y : Viral loadand ganciclovir (GCV) concentration in cerebrospinal
fluid of patients successfully treated with GCV or valGCV
for human herpesvirus 6 encephalitis/myelitis following
umbilical cord blood transplantation. Transpl Infec Dis 18:
773-776, 2016.

20160151
Yanagisawa R, Ogiso Y, Miyairi Y, Sakashita
K, Shigeta H : Multinucleated giant cells in Langerhans cellhistiocytosis. Br J Haematol 174: 7-7, 2016.

20160144
Hachiya A, Motoki N, Akazawa Y, Matsuzaki
S, Hirono K, Hata Y, Nishida N, Ichida F, Koike K : Leftventricular non-compaction revealed by aortic regurgitation
due to Kawasaki disease in a boy with LDB3 mutation.
Pediatr Int 58: 797-800, 2016.

20160153
Komori K, Yanagisawa R, Fujihara I, Kanai
H, Sakashita K : Failure to Thrive and Bilateral Periorbital
Ecchymosis. J Pediatr 172: 215-215, 2016.

20160145
Chen L, Al-Kzayer LF, Liu T, Kobayashi N,
Nakazawa Y, Koike K : IFR4/MUM1-positive lymphoma in
Waldeyer ring with co-expression of CD5 and CD10. Pediatr
Blood Cancer 64: 311-314, 2016.
20160146
A k a z a w a Y, H a c h i y a A , Ya m a z a k i S ,Kawasaki Y, Nakamura C, Takeuchi Y, Kusakari M,
Miyosawa Y, Kamiya M, Motoki N, Koike K, Nakamura
T : Cardiovascular Remodeling and Dysfunction
Across a Range of Growth Restriction Severity in Small
for Gestational Age Infants - Implications for Fetal
Programming. Circ J 80: 2212-2220, 2016.
20160147
Akazawa Y, Motoki N, Tada A, Yamazaki S,
Hachiya A, Matsuzaki S, Kamiya M, Nakamura T, Kosho
T, Inaba Y : Decreased Aortic Elasticity in Children With
Marfan Syndrome or Loeys-Dietz Syndrome. Circ J 80:
2369-2375, 2016.
20160148
Shigemura T, Ohno Y, Sano K, Uehara T, Terada
M, Koike K, Nakazawa Y : Gangrenous appendicitis in apatient with severe congenital neutropenia. Pediatr Int 58:
1093-1094, 2016.
20160149
Inaba Y, Motobayashi M, Nishioka M, Kaneko
T, Yamauchi S, Kawasaki Y, Shiba N, Nishio SY, Moteki H,
Miyagawa M, Takumi Y, Usami S, Koike K : Correlation
Between White Matter Lesions and Intelligence Quotient inPatients With Congenital Cytomegalovirus Infection. Pediatr
Neurol 55: 52-57, 2016.
20160150
Yanagisawa R, Nakazawa Y, Sakashita K,
Saito S, Tanaka M, Shiohara M, Shimodaira S, Koike K :Intrathecal donor lymphocyte infusion for isolated leukemia
relapse in the central nervous system following allogeneic
stem cell transplantation: a case report and literature review.
Int J Hematol 103: 107-111, 2016.

20160152
Koike Y, Yanagisawa R, Ogiso Y, Cho Y,
Minami K, Takeuchi K, Sakashita K, Higuchi T : Transient
Deformation of Neutrophils in Kawasaki Disease. J Pediatr
173: 238-241, 2016.

20160154
Fujihara I, Yanagisawa R, Fukushima Y, Komori
K, Ogiso Y, Sakashita K : Thrombocytosis in a newborn with
Down syndrome and transient abnormal myelopoiesis. Br J
Haematol 172: 314-314, 2016.
20160155
Ya n a g i s a w a R , N o g u c h i M , F u j i t a K ,Sakashita K, Sano K, Ogiso Y, Katsuyama Y, Kondo Y,
Komori K, Fujihara I, Kitamura R, Hiroma T, Nakamura
T : Preoperative Treatment With Pazopanib in a Case of
Chemotherapy-Resistant Infantile Fibrosarcoma. Pediatr
Blood Cancer 63: 348-351, 2016.
20160156
Komori K, Yanagisawa R, Miyairi Y, Sakashita
K, Shiohara M, Fujihara I, Morita D, Nakamura T, Ogiso Y,
Sano K, Shirahata M, Fukuoka K, Ichimura K, Shigeta H :Temozolomide Treatment for Pediatric Refractory Anaplastic
Ependymoma with Low MGMT Protein Expression. Pediatr
Blood Cancer 63: 152-155, 2016.

Dermatology
20160157
Shirai T, Sano T, Kamijo F, Saito N, Miyake
T, Kodaira M, Katoh N, Nishie K, Okuyama R, Uhara
H : Acetylcholine receptor binding antibody-associatedmyasthenia gravis and rhabdomyolysis induced bynivolumab in a patient with melanoma. Jpn J Clin Oncol 46:
86-88, 2016.
20160158
Ts u j i A , M i n a g a w a A , O k u y a m a R :Erythematous papules and plaques on the cheeks. JAMA
Dermatol 152: 569-570, 2016.
20160159
Edamitsu T, Minagawa A, Koga H, Uhara H,
Okuyama R : Eccrine porocarcinoma shares dermoscopic
characteristics with eccrine poroma: A report of three cases
and review of the published work. J Dermatol 43: 332-335,
2016.
20160160
Sano T, Uhara H, Mikoshiba Y, Kobayashi
A, Uchiyama R, Tateishi K, Yamamoto H, Okuyama R :13

Nivolumab-induced organizing pneumonia in a melanoma
patient. Jpn J Clin Oncol 46: 270-272, 2016.

papillomavirus type 47 in a HIV-infected patient. J Dermatol
43: 717-718, 2016.

20160161
Asai Y, Uhara H, Miyazaki A, Saiki M,
Okuyama R : Late onset of acute urticaria after bee stings.
Case Rep Dermatol 8: 341-343, 2016.

20160172
Ashida A, Ogawa E, Uhara H, Koizumi T,
Okuyama R : Inhibition of epidermal growth factor receptor
induces tumor necrosis factor-α via activation of peroxisome
proliferator-activated receptor-γ and nuclear factor-κB in
sebocytes: A possible pathogenesis of papulopustular rash. J
Dermatol Sci 82: 53-56, 2016.

20160162
Nakamura K, Okuyama R : Immunotherapy
for advanced melanoma: Current knowledge and future
directions. J Dermatol Sci 83: 87-94, 2016.
20160163
Mikoshiba Y, Ogawa E, Uchiyama R, Uchiyama
A, Uhara H, Okuyama R : 5-Hydroxymethylcytosine is a
useful marker to differentiate between dermatofibrosarcoma
protuberans and dermatofibroma. J Eur Acad Dermatol
Venereol 30: 130-131, 2016.
20160164
Miyake T, Kiniwa Y, Kosho T, Nakano H,
Okuyama R : Hypohidrotic ectodermal dysplasia: A report oftwo cases. J Dermatol 44: 479-481, 2016.

20160173
Ashida A, Uhara H, Mikoshiba A, Sakaizawa K,
Kumagai N, Koga H, Okuyama R : Melanoma with BRAF
mutation in circulating cell-free DNA despite no mutation in
the primary lesion: A case report. Acta Derm Venereol 96:
128-129, 2016.
20160174
Koga H, Yoshikawa S, Shinohara T, Le Gal
FA, Cortés B, Saida T, Sota T : Long-term follow-up of
longitudinal melanonychia in children and adolescents using
an objective discrimination index. Acta Derm Venereol 96:
716-717, 2016.

20160165
Kobayashi Y, Akiyama H, Huge J, Kubota H,
Chikazawa S, Satoh T, Miyake T, Uhara H, Okuyama R,
Nakagawara R, Aihara M, Hamada-Sato N : Fish collagen is
an important panallergen in the Japanese population. Allergy
71: 720-723, 2016.

20160175
Hayashi K, Okuyama R, Uhara H : Water-based
correction fluid is a useful skin marker for determinationof the tumor margin of basal cell carcinoma under highfrequency ultrasound. J Dermatol 43: 823-825, 2016.

20160166
Okada N, Fujii C, Matsumura T, Kitazawa M,
Okuyama R, Taniguchi S, Hida S : Novel role of ASC asa regulator of metastatic phenotype. Cancer Med 5: 24872500, 2016.

20160176
Kiniwa Y, Matoba H, Hamano H, Senoo Y,
Okuyama R : Cutaneous plasmacytosis associated with
autoimmune hemolytic anemia. J Dermatol 43: 343-345,
2016.

20160167
Ta k a z a w a Y, E d a m i t s u T, M a e n o K ,Ogawa E, Uhara H, Kawachi S, Ito K, Okuyama R :5-Hydroxymethylcytosine as a putative marker for erosive
adenomatosis of the nipple. J Dermatol 43: 579-580, 2016.
20160168
Minagawa A, Tanaka M, Koga H, Okuyama R :Pigmented seborrheic keratosis showing starburst pattern. J
Am Acad Dermatol 75: e11-e13, 2016.

20160177
Inoue H, Park JH, Kiyotani K, Zewde M,
Miyashita A, Jinnin M, Kiniwa Y, Okuyama R, Tanaka
R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N,
Yokota K, Akiyama M, Ihn H, Fukushima S, Nakamura
Y : Intratumoral expression levels of PD-L1, GZMA,
and HLA-A along with oligoclonal T cell expansion
associate with response to nivolumab in metastaticmelanoma. Oncoimmunology 5: e1204507, 2016.

20160169
Minagawa A, Omodaka T, Okuyama R :Melanomas and mechanical stress points on the plantar
surface of the foot. N Engl J Med 374: 2404-2406, 2016.

20160178
Uhara H, Sano T, Miyake T, Okuyama R :Orange pigmentation spots on the sole may be from a stinkbug. J Dermatol 43: 1247-1248, 2016.

20160170
Ashida A, Sakaizawa K, Mikoshiba A, Uhara
H, Okuyama R : Quantitative analysis of the BRAF V600E
mutation in circulating tumor-derived DNA in melanoma
patients using competitive allele-specific TaqMan PCR. Int J
Clin Oncol 21: 981-988, 2016.

20160179
Ohara K, Fujisawa Y, Yoshino K, Kiyohara Y,
Kadono T, Murata Y, Uhara H, Hatta N, Uchi H, Matsushita
S, Takenouchi T, Hayashi T, Yoshimura K, Fujimoto M : A
proposal for a TNM staging system for extramammary Paget
disease: Retrospective analysis of 301 patients with invasive
primary tumors. J Dermatol Sci 83: 234-239, 2016.

20160171
Ashida A, Shimizu A, Okuyama R : Acquired
epidermodysplasia verruciformis associated with human

20160180

Yamazaki N, Uhara H, Wada H, Matsuda K,

14

Yamamoto K, Shimamoto T, Kiyohara Y : Phase I studyof pegylated interferon-alpha-2b as an adjuvant therapy inJapanese patients with malignant melanoma. J Dermatol 43:
1146-1153, 2016.
20160181
Ts u t s u m i d a A , Ta k a h a s h i A , N a m i k a w a
K, Yamazaki N, Uhara H, Teramoto Y, Takenouchi T,
Fukushima S, Yokota K, Uehara J, Matsushita S, Shibayama
Y, Hatta N, Masui Y, Uchi H, Fujisawa Y, Ogata D :Frequency of level II and III axillary nodes metastases inpatients with positive sentinel lymph nodes in melanoma: amulti-institutional study in Japan. Int J Clin Oncol 21: 796800, 2016.
20160182
Yoshino K, Fujisawa Y, Kiyohara Y, Kadono
T, Murata Y, Uhara H, Hatta N, Uchi H, Matsushita S,
Takenouchi T, Hayashi T, Ohara K : Usefulness of docetaxel
as first-line chemotherapy for metastatic extramammary
Paget's disease. J Dermatol 43: 633-637, 2016.
20160183
Ohata C, Ishii N, Niizeki H, Shimomura Y,
Furumura M, Inoko H, Mitsunaga S, Saiki M, Shigeta M,
Fujiwara S, Yamakawa K, Kobayashi S, Kamata M, Inaba
M, Ito T, Uhara H, Watanabe R, Ohtoshi S, Ohashi T, Tanaka
T, Suzuki M, Sitaru C, Kárpáti S, Zone JJ, Hashimoto T :Unique characteristics in Japanese dermatitis herpetiformis.
Br J Dermatol 174: 180-183, 2016.
20160184
Kono M, Matsumoto F, Suzuki Y, Suganuma
M, Saitsu H, Ito Y, Fujiwara S, Moriwaki S, Matsumoto
K, Matsumoto N, Tomita Y, Sugiura K, Akiyama M :Dyschromatosis Symmetrica Hereditaria and AicardiGoutières Syndrome 6 Are Phenotypic Variants Caused by
ADAR1 Mutations. J Invest Dermatol 136: 875-878, 2016.
20160185
Yamamoto T, Ohtsuki M, Sano S, Igarashi A,
Morita A, Okuyama R, Kawada A; Working Group of the
Epidemiological Survey in the Japanese Society for Psoriasis
Research : Epidemiological analysis of psoriatic arthritis
patients in Japan. J Dermatol 43: 1193-1196, 2016.

Radiology
20160186
K o i w a i K , S a s a k i S , Yo s h i z a w a E , I n a
H, Fukazawa A, Sakai K, Matsushita H, Kadoya M :Palliative radiotherapy for Japanese patients with malignant
melanoma: a single-institution experience. Jpn J Radiol 34:
125-129, 2016.
20160187
Fujinaga Y, Kitou Y, Ohya A. Adachi Y,
Tamaru N, Shiobara A, Ueda H, Nickel MD, Maruyama
K, Kadoya M : Advantages of radial volumetric breathhold examination (VIBE) with k-space weighted image

contrast reconstruction (KWIC) over Cartesian VIBE in liver
imaging of volunteers simulating inadequate or no breathholding ability. Eur Radiol 26: 2790-2797, 2016.
20160188
Kaneko T, Kaneko K, Kadoya M : Averaging
diffusion-weighted images affects the analysis of the
diffusion tensor in vivo. Shinshu Medical Journal 64: 113121, 2016.
20160189
Matsushita T, Mitsui T, Kaneko T, Ueda H,
Kadoya M : Functional magnetic resonance imaging study ofbrain activation by sound localization in artifical unilateral
hearing loss. Shinshu Medical Journal 64: 123-133, 2016.
20160190
Yanagisawa S, Matsushita T, Yasuo M, Machida
R, Ishii W, Kadoya M : Usefulness of F-18 FDG PET/CT ina case of relapsing polychondritis. Shinshu Medical Journal
64: 349-355, 2016.

Surgery 1
20160191
Arai T, Kobayashi A, Fujinaga Y, Yokoyama
T, Shimizu A, Motoyama H, Kitagawa N, Notake T,
Shirota T, Fukushima K, Masuo H, Kadoya M, Miyagawa
S : Contrast-enhancement ratio on multiphase enhanced
computed tomography predicts recurrence of pancreatic
neuroendocrine tumor after curative resection. Pancreatology
16: 397-402, 2016.
20160192
Shigemura T, Ohno Y, Sano K, Uehara T, Terada
M, Koike K, Nakazawa Y : Gangrenous appendicitis in apatient with severe congenital neutropenia. Pediatr Int 58:
1093-1094, 2016.
20160193
Hosoda K, Kobayashi A, Shimizu A, Kitagawa
N, Ito T, Yamada A, Miyagawa S : Neuroendocrine tumor of
the common bile duct. Surgery 160: 525-526, 2016.
20160194
Hasegawa K, Saiura A, Takayama T, Miyagawa
S, Yamamoto J, Ijichi M, Teruya M, Yoshimi F, Kawasaki S,
Koyama H, Oba M, Takahashi M, Mizunuma N, Matsuyama
Y, Watanabe T, Makuuchi M, Kokudo N : Adjuvant Oral
Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver
Metastases: A Randomized Controlled Trial. PLoS One 11:
e0162400, 2016.
20160195
S h i m i z u A , K o b a y a s h i A , Yo k o y a m a T,
Motoyama H, Sakai H, Kitagawa N, Notake T, Shirota
T, Fukushima K, Miyagawa SI : Correlation between
the serum levels of type IV collagen 7s domain and therisk of intractable ascites following liver resection forhepatocellular carcinoma: A propensity score-matchedanalysis. Surgery 160: 1244-1255, 2016.

15

Surgery 2
20160196
Yamanaka K, Matsueda T, Miyahara S, Nomura
Y, Sakamoto T, Morimoto N, Inoue T, Matsumori M, Okada
K, Okita Y : Surgical strategy for aortic prosthetic graft
infection with 18F-fluorodeoxyglucose positron emission
tomography/computed tomography. Gen Thorac Cardiovasc
Surg 64(9): 549-551, 2016.
20160197
Yu J, Morimoto K, Bao W, Yu Z, Okita Y,
Okada K : Glucagon-like peptide-1 prevented abdominal
aortic aneurysm development in rats. Surg Today 46(9):1099-1107, 2016.
20160198
Omura A, Miyahara S, Yamanaka K, Sakamoto
T, Matsumori M, Okada K, Okita Y : Early and lateoutcomes of repaired acute DeBakey type I aortic dissection
after graft replacement. J Thorac Cardiovasc Surg 151(2):341-348, 2016.
20160199
Yu Z, Morimoto K, Yu J, Bao W, Okita Y,
Okada K : Endogenous superoxide dismutase Activation by
Oral Administration of Riboflavin Inhibits Abdominal Aortic
Aneurysm Formation in Rats. J Vasc Surg 64(3): 737-745,
2016.
20160200
Onoda N, Sugino K, Higashiyama T, Kammori
M, Toda K, Ito K, Yoshida A, Suganuma N, Nakashima N,
Suzuki S, Tsukahara K, Noguchi H, Koizumi M, Nemoto T,
Hara H, Miyauchi A, Sugitani I : The Safety and Efficacyof Weekly Paclitaxel Administration for Anaplastic Thyroid
Cancer Patients: A Nationwide Prospective Study. Thyroid
26(9): 1293-1299, 2016.
20160201
Ito Y, Suzuki S, Ito K, Imai T, Okamoto
T, Kitano H, Sugitani I, Sugino K, Tsutsui H, Hara H,
Yoshida A, Shimizu K : Tyrosine-kinase inhibitors to treat
radioiodine-refracted, metastatic, or recurred and progressive
differentiated thyroid carcinoma. Endocr J 63(7): 597-602,
2016.
20160202
Maeno K, Ito T, Koyama H, Kanai T, Mochizuki
Y, Ito K : Significance of sentinel lymph nodes with low
gamma counts in breast cancer patients via radioisotopic
sentinel lymph node biopsy. Arch Surg Oncol 2: 109, 2016.
20160203
Hanamura T, Ito T, Kanai T, Maeno K, Shimojo
Y, Uehara T, Suzuki T, Hayashi S, Ito K : Human 3βhydroxysteroid dehydrogenase type 1 in human breast
cancer: clinical significance and prognostic associations.
Cancer Med 5(7): 1405-1415, 2016.

20160204
Oba T, Ono M, Iesato A, Hanamura T, Watanabe
T, Ito T, Kanai T, Maeno K, Ito K, Tateishi A, Yoshizawa
A, Takayama F : Lipid-rich carcinoma of the breast that isstrongly positive for estrogen receptor: a case report andliterature review. Onco Targets Ther 9: 1641-1646, 2016.
20160205
Oba T, Izumi H, Ito K : ABCB1 and ABCC11
confer resistance to eribulin in breast cancer cell lines.
Oncotarget 7(43): 70011-70027, 2016.
20160206
Matsumura Y, Yano M, Yoshida J, Koike T,
Kameyama K, Shimamoto A, Nishio W, Yoshimoto K,
Utsumi T, Shiina T, Watanabe A, Yamato Y, Watanabe
T, Takahashi Y, Sonobe M, Kuroda H, Oda M, Inoue M,
Tanahashi M, Adachi H, Saito M, Hayashi M, Otsuka H,
Mizobuchi T, Moriya Y, Takahashi M, Nishikawa S, Suzuki
H : Early and late recurrence after intentional limited
resection for cT1aN0M0, non-small cell lung cancer: from amulti-institutional, retrospective analysis in Japan. Interact
Cardiovasc Thorac Surg 23(3): 444-449, 2016.
20160207
Yano M, Yoshida J, Koike T, Kameyama K,
Shimamoto A, Nishio W, Yoshimoto K, Utsumi T, Shiina T,
Watanabe A, Yamato Y, Watanabe T, Takahashi Y, Sonobe
M, Kuroda H, Oda M, Inoue M, Tanahashi M, Adachi H,
Saito M, Hayashi M, Otsuka H, Mizobuchi T, Moriya Y,
Takahashi M, Nishikawa S, Matsumura Y, Moriyama S, Fujii
Y : The Outcomes of a Limited Resection for Non-Small
Cell Lung Cancer Based on Differences in Pathology. WorldJ Surg 40(11): 2688-2697, 2016.
20160208
Zhang M, Yoshizawa A, Kawakami S, Asaka S,
Yamamoto H, Yasuo M, Agatsuma H, Toishi M, Shiina T,
Yoshida K, Honda T, Ito K : The histological characteristics
and clinical outcomes of lung cancer in patients withcombined pulmonary fibrosis and emphysema. Cancer Med
5(10): 2721-2730, 2016.
20160209
Hamanaka K, Ohashi M, Nakamura T : Primary
mediastinal dedifferentiated liposarcoma resected by lateralthoracotomy with video-assisted thoracoscopic surgery. J
Surg Case Rep 2016: rjv163, 2016.
20160210
Miura K, Kondo R : Complete Response of
Advanced Invasive Mucinous Adenocarcinoma of the Lungwith Gemcitabine and Pemetrexed. Shinshu Medical Journal
64(2): 79-83, 2016.
20160211
Miura K, Toishi M, Hamanaka K, Shiina T :Right Upper-lower Bilobectomy for Double Primary Nonsmall Cell Lung Cancer. American journal of Cancer Case
Reports 4(1): 72-76, 2016.

16

20160212
Ohue Y, Matsuoka S, Kumeda H, Agatsuma
H, Hyougotani A, Toishi M, Shiina T, Yoshida K, Shingu
K, Fukushima T, Koizumi T : Development of combined
thymic carcinoma and thymoma in an extrathymic lesion
during long follow-up for recurrent thymoma. Mol Clin
Oncol 4(2): 139-142, 2016.

density. J Clin Densitom 19: 270-276, 2016.

Orthopaedic Surgery

20160221
Takahara K, Kamimura M, Moriya H, Ashizawa
R, Koike T, Hidai Y, Ikegami S, Nakamura Y, Kato H : Risk
factors of adjacent vertebral collapse after percutaneousvertebroplasty for osteoporotic vertebral fracture inpostmenopausal women. BMC Musculoskelet Disord 17: 12,2016.

20160213
Kito M, Yoshimura Y, Isobe K, Aoki K,
Suzuki S, Tanaka T, Okamoto M, Sano K, Kato H :Clinical Outcome of Dedifferentiated Liposarcoma in the
Extremities: A Retrospective Case Series of 7 Patients. J
Orthop Sci 21: 673-677, 2016.

20160222
Kuroda C, Haniu H, Ajima K, Tanaka M,
Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K,
Kato H, Saito N : The dispersion state of tangled multiwalled carbon nanotubes affects their cytotoxicity.
Nanomaterials (Basel) 6: 219, 2016.

20160214
Uehara M, Tsutsumimoto T, Yui M, Ohta H,
Oba H, Misawa H : Single-stage surgery for compressive
thoracic myelopathy associated with compressive cervicalmyelopathy and/or lumbar spinal stenosis. Eur Spine J 25:
1904-1911, 2016.

20160223
Shimodaira H, Tensho K, Akaoka Y, Takanashi
S, Kato H, Saito N : Remnant-preserving tibial tunnel
positioning using anatomical landmarks in double-bundle
anterior cruciate ligament reconstruction. Arthroscopy 32:
1822-1830, 2016.

20160215
Itsubo T, Uchiyama S, Yamazaki H, Hayashi
M, Nakamura K, Kuniyoshi K, Kato H : Factors affecting
extension lag after tendon reconstruction for finger extensor
tendon rupture due to distal radioulnar lesion. J Orthop Sci
21: 19-23, 2016.

20160224
Kuraishi S, Takahashi J, Mukaiyama K, Shimizu
M, Ikagami S, Futatsugi T, Hirabayashi H, Ogihara N,
Hashidate H, Tateiwa Y, Kinoshita H, Kato H : Comparisonof clinical and radiological results of posterolateral fusionand posterior lumbar interbody fusion in the treatment of L4
degenerative lumbar spondylolisthesis. Asian Spine J 10:
143-152, 2016.

20160216
Tanaka A, Yoshimura Y, Aoki K, Kito M,
Okamoto M, Suzuki S, Momose T, Kato H : Knee extension
strength and post-operative functional prediction inquadriceps resection for soft-tissue sarcoma of the thigh.
Bone Joint Res 5: 232-238, 2016.
20160217
Yoshida K, Maruyama M, Kasama K, Hashidate
H, Kitagawa K : Open Reduction by Fenestration to theIlium for Central Acetabular Depression Fractures:A Case
Report and Operative Technique. Open J Orthop 6: 221-226,
2016.
20160218
Yoshida K, Kasama K, Akahane T : Avulsion
Fracture of the Calcaneus Treated With a Soft Anchor Bridgeand Lag Screw Technique: A Report of Two Cases. J Foot
Ankle Surg 55: 310-313, 2016.
20160219
K a m i m u r a M , N a k a m u r a Y, S u g i n o N ,Uchiyama S, Komatsu M, Ikegami S, Kato H, Taguchi A :Associations of self-reported height loss and kyphosis withvertebral fractures in Japanese women 60 years and older: across-sectional survey. Sci Rep 6: 29919, 2016.
20160220
Ikegami S, Kamimura M, Uchiyama S,
Nakamura Y, Mukaiyama K, Kato H : Clinical implicationsof hip flexion in the measurement of spinal bone mineral

20160225
Takahashi J, Hirabayashi H, Hashidate H,
Ogihara N, Mukaiyama K, Komatsu M, Inaba Y, Kosho
T, Kato H : Challenges of transarticular screw fixation inyoung children: Report of surgical treatment of a 5-year-old
patient’s unstable os-odontoideum. Asian Spine J 10: 950954, 2016.
20160226
Akaoka Y , Yamazaki H, Kodaira H, kato H :Risk factors for the effect of anticoagulant and antiplatelet
agents on perioperative blood loss following proximal
femoral fractures. Medicine (Baltimore) 95: e4120, 2016.
20160227
Yoshimura Y, Sano K, Isobe KI, Aoki K, Kito
M, Kato H : A recurrent solitary fibrous tumor of the thighwith malignant transformation: A case report. Int J Surg Case
Rep 21: 111-114, 2016.
20160228
Nakamura Y, Uchiyama S, Kamimura M,
Komatsu M, Ikegami S, Kato H : Bone alterations areassociated with ankle osteoarthritis joint pain. Sci Rep 6:18717, 2016.
20160229
Nishimura M, Itsubo T, Horii E, Hayashi M,
Uchiyama S, Kato H : Tardy ulnar nerve palsy caused by17chronic radial head dislocation after Monteggia fracture: areport of two cases. J Pediatr Orthop B 25: 450-453, 2016.
20160230
Karube T, Uchiyama S, Murai T, Yamazaki
H, Kato H : Functional evaluation and DASH scores ofa patient treated with second toe-to-thumb transfers forbilateral thumb amputations: A case report. J Orthop Sci 21:
97-99, 2016.
20160231
K a m i m u r a M , N a k a m u r a Y, I k e g a m i S ,Uchiyama S, Kato H : Bisphosphonate Pre-Treatment
Diminishes the Therapeutic Benefits of Teriparatide inJapanese Osteoporotic Patients. Tohoku J Exp Med 239:
17-24, 2016.
20160232
Ido Y, Uchiyama S, Nakamura K, Itsubo T,
Hayashi M, Hata Y, Imaeda T, Kato H : Postoperative
improvements in DASH score, clinical findings, and nerve
conduction velocity in patients with cubital tunnel syndrome.
Sci Rep 6: 27497, 2016.
20160233
Taguchi A, Kamimura M, Sugino N, Uchida K,
Kitamura Y, Ikegami S, Nakamura Y, Uchiyama S, Kato H: Association of self-reported height loss and kyphosis withloss of teeth in Japanese elderly. Oral Health Dent Manag
15: 69-74, 2016.
20160234
N a k a m u r a Y, I k e g a m i S , Ta k a n a s h i Y,
Kamimura M, Uchiyama S, Kato H : Value changes inbone turnover markers and bone mineral density using
ibandronate in Japanese postmenopausal osteoporotic
patients. J Nutr Disord Ther 6: 188, 2016.
20160235
Oshiba H, Itsubo T, Ikegami S, Nakamura K,
Uchiyama S, Kato H : Results of Bone Peg Grafting for
Capitellar Osteochondritis Dissecans in Adolescent BaseballPlayers. Am J Sports Med 44: 3171-3178, 2016.
20160236
Ta g u c h i A , K a m i m u r a M , N a k a m u r a Y,
Sugino N, Ichinose A, Maezumi H, Fukuzawa T, Ashizawa
R, Takahara K, Gushiken S, Mukaiyama K, Ikegami S,
Uchiyama S, Kato H : Delayed wound healing after tooth
extraction and self-reported kyphosis in Japanese men andwomen. Sci Rep 6: 36309, 2016.

inhibitor dynasore inhibits bone resorption by rapidly
disrupting actin rings of osteoclasts. J Bone Miner Metab 34:
395-405, 2016.
20160239
Isobe F, Nakamura Y, Kamimura M, Uchiyama
S, Kato H : Effects of Denosumab Treatment during Early
Pregnancy - A Case Report. J Nutr Disord Ther 6: 189, 2016.
20160240
K a m i m u r a M , N a k a m u r a Y, I k e g a m i S ,Komatsu M, Uchiyama S, Kato H : Monthly minodronate
inhibits bone resorption to a greater extent than does
monthly risedronate. Osteoporos Sarcopenia 2: 170-174,
2016.
20160241
Momose T, Yoshimura Y, Harumiya S, Isobe K,
Kito M, Fukushima M, Kato H, Nakayama J : Chondroitin
sulfate synthase 1 expression is associated with malignant
potential of soft tissue sarcomas with myxoid substance.
Hum Pathol 50: 15-23, 2016.
20160242
Hata Y, Ishigaki N, Matsuba T : Mini-Open
Rotator Cuff Repair. In: Tamai K, Itoi E, Takagishi K.
Advances in Shoulder Surgery. Tokyo: Springer Japan; 2016.
p.145-156.
20160243
Tensho K : Tibial Insertion of the ACL: 3D-CT
Images, Macroscopic, and Microscopic Findings. In: Ochi
M, Shino K, Yasuda K, Kurosaka M. ACL injury and its
Treatment. Tokyo: Springer Japan; 2016. p.39-50.

Neurosurgery
20160244
Horiuchi T, Yamamoto Y, Suzuki Y, Kobayashi
M, Ichinose S, Hongo K : Clipping Surgery for Paraclinoid
Carotid Aneurysm. Acta Neurochir (Wien) Suppl. 123:
27-32, 2016.
20160245
Ito K, Seguchi T, Nakamura T, Chiba A,
Hasegawa T, Nagm A, Horiuchi T, Hongo K : Evaluation ofMetallic Artifacts Caused by Nonpenetrating Titanium Clips
in Postoperative Neuroimaging. World Neurosurg 96: 16-22,
2016.

20160237
Yamazaki H, Uchiyama S, Hosaka M, Kato H :Closed Rupture of the Flexor Tendon Secondary to Sclerosisof the Hook of the Hamate: A Report of Two Cases. J Hand
Surg Asian Pac Vol 21: 405-409, 2016.

20160246
Ito K, Aoyama T, Nakamura T, Hanaoka Y,
Horiuchi T, Hongo K : Novel dural incision and closure
procedure for preventing postoperative cerebrospinal fluid
leakage during the surgical removal of dumbbell-shaped
spinal tumors: technical note. J Neurosurg Spine 25: 620625, 2016.

20160238
Thirukonda GJ, Uehara S, Nakayama T,
Yamashita T, Nakamura Y, Mizoguchi T, Takahashi N,
Yagami K, Udagawa N, Kobayashi Y : The dynamin

20160247
Ito K, Aoyama T, Miyaoka Y, Seguchi T,
Horiuchi T, Hongo K : Surgery for ventral intradural thoracic
spinal tumors with a posterolateral transpedicular approach.

18

Acta Neurochir (Wien) 158: 1563-1569, 2016.
20160248
Kanaya K, Ito K, Horiuchi T, Hongo K :"Dynamic" Rotational Canal Stenosis Caused by Osteomaof the Atlas: A Case Report and Review of Literature. NMC
Case Rep J 3(1): 17-20, 2016.
20160249
Murata T, Dietrich HH, Horiuchi T, Hongo
K, Dacey RG Jr : Mechanisms of magnesium-induced
vasodilation in cerebral penetrating arterioles. Neurosci Res
107: 57-62, 2016.
20160250
Murata T, Nagashima H, Ichinose S, Uchiyama
T, Koyama J, Hongo K : Successful Stentings for Bilateral
Jugular Bulb Stenosis/Occlusion in a Case of Bilateral
Transverse Sinuses Dural Arteriovenous Fistulas: Case
Report. Journal of Neuroendovascular Therapy 10: 127-133,
2016.
20160251
Nagm A, Horiuchi T, Kanaya K, Hongo
K : Dural Arteriovenous Fistula Could Be due to
Hemodynamic Disturbance in Dural Physiological
Shunts? Histopathological Study and a Case Report. World
Neurosurg 90: 699.e11-699.e18, 2016.
20160252
Ngerageza JG, Horiuchi T, Murata T, Aoyama T,
Hongo K : Iatrogenic dural arteriovenous fistula after radical
neck dissection for metastatic malignant disease: A casereport. Head Neck 38: E87-E90, 2016.
20160253
Nagm A, Horiuchi T, Hasegawa T, Hongo
K : Intraoperative Evaluation of Reverse Bypass Using a
Naturally Formed "Bonnet" Superficial Temporal Artery:Technical Note. World Neurosurg 88: 603-608, 2016.
20160254
N a g m A , H o r i u c h i T, I t o K , H o n g o K: Relationship Between Successful ExtracranialIntracranial Bypass Surgeries and Ischemic White Matter
Hyperintensities. World Neurosurg 91: 112-120, 2016.
20160255
Nagm A, Horiuchi T, Yanagawa T, Hongo K :Risky Cerebrovascular Anatomic Orientation: Implications
for Brain Revascularization. World Neurosurg 96: 610.e15610.e20, 2016.
20160256
Ogiwara T, Goto T, Aoyama T, Nagm A,
Yamamoto Y, Hongo K : Bony surface registration ofnavigation system in the lateral or prone position: technicalnote. Acta Neurochir (Wien) 157(11): 2017-2022, 2016.
20160257
Ogiwara T, Goto T, Aoyama T, Hara Y, Nagm
A, Tanaka Y, Hongo K : Relationship Between Muscle
Dissection Method and Postoperative Muscle Atrophy in the

Lateral Suboccipital Approach to Vestibular Schwannoma
Surgery. World Neurosurg 94: 426-431, 2016.
20160258
Yasuhara T,Kuwahara K, Sasada S, Toyoshima
A, Morimoto J, Kin K, Manabe H, Miyoshi Y, Kusumegi A,
Takahashi Y, Ito K, Date I : Surgery in the Standing Position
by a Surgeon with Achilles Tendon Rupture. Acta Med
Okayama 70: 493-496, 2016.
20160259
Horiuchi T, Hongo K : General principles ofaneurysm surgery. In: Sekhar LN, Fessler RG. Atlas of
Neurosurgical Techniques: Brain Volume 1, 2nd Edition.
New York: Thieme Medical Publishers; 2016. p.113-121.
20160260
Hongo K, Horiuchi T : Occipital transtentorial
and parietal approaches. In: Sekhar LN, Fessler RG. Atlasof Neurosurgical Techniques: Brain Volume 2, 2nd Edition.
New York: Thieme Medical Publishers; 2016. p.181-186.

Dentistry & Oral Surgery
20160261
Yamada S, Kurita H, Shimane T, Kamata T,
Uehara S, Tanaka H, Yamamoto T : Estimation of the widthof free margin with a significant impact on local recurrencein surgical resecion of oral squamous cell carcinoma. Int J
Oral Maxillofac Surg 45: 147-152, 2016.
20160262
Nishimaki F, Kurita H, Tozawa S, Teramoto
Y, Nishizawa R, Yamada S : Subjective and qualitative
assessment of neural disurbance after inferior alveolar nerve
transposition for dental implant placement. Int J Implant
Dent 2: 14, 2016.
20160263
Teramoto Y, Kurita H, Kamata T, Aizawa H,
Yoshimura N, Nishimaki F, Takamizawa K : A cace of periimplantitis and osteoradionecrosis arising around dental
implants placed before radiation therapy. Int J Implant Dent
2: 11, 2016.
20160264
Shimane T, Aizawa H, Koike T, Kamiya M,
Urano Y, Kurita H : Oral cancer intraoperative detection
by topically spraing a γ-glutamyl transpeptidase-activatedfluorescent probe. Oral Oncol 54: e16-e18, 2016.
20160265
Okura M, Yanamoto S, Umeda M, Otsuru
M, Ota Y, Kurita H, Kamata T, Kirita T, Yamakawa N,
Yamashita T, Ueda M, Komori T, Hasegawa T, Aikawa
T; Japan Oral Oncology Group : Prognostic and staging
implications of mandibular canal invastion in lower gingival
squamous cell carcinoma. Cancer Med 5(12): 3378-3385,
2016.
20160266

Yamada S, Yanamoto S, Naruse T, Matsushita19

Y, Takahashi H, Umeda M, Nemoto TK, Kurita H : SKp2
Regulates the Expression of MMP-2 and MMP-9,and
Enhances the Invasion Potential of Oral Squamous Cell
Carcinoma. Pathol Oncol Res 22(3): 625-632, 2016.

Urology
20160267
Minagawa T, Suzuki T, Domen T, Yokoyama
H, Ishikawa M, Hirakata S, Nagai T, Nakazawa M, Ogawa
T, Ishizuka O : Modified sonourethrography assists urethralcatheterization. J Med Ultrason (2001) 43: 443-448, 2016.
20160268
Minagawa T, Saitou T, Suzuki T, Domen T,
Yokoyama H, Ishikawa M, Hirakata S, Nagai T, Nakazawa
M, Ogawa T, Ishizuka O : Impact of ao-dake-humi, Japanesetraditional bamboo foot stimulator, on lower urinary tract
symptoms, constipation and hypersensitivity to cold: asingle-arm prospective pilot study. BMC Complement Altern
Med 16: 513, 2016.
20160269
Yokoyama H, Hara H, Ogawa T, Ishizuka O :Acute cholecystitis after urological surgery: A report of 11
cases in our department and a review of the literature. J Clin
Urol 9: 156-161, 2016.
20160270
Yokoyama H, Domen T, Hiragata S, Ogawa
T, Matsumoto T, Ishizuka O : Postoperative Mycoplasma
hominis infection after robot-assisted laparoscopic radical
prostatectomy: A case report. Asian J Endosc Surg 9: 146148, 2016.

e22-e23, 2016.

Otorhinolaryngology
20160275
Yoshimura H, Miyagawa M, Kumakawa K,
Nishio S, Usami S : Frequency of Usher syndrome type 1 indeaf children by massively parallel DNA sequencing. J Hum
Genet 61: 419-422, 2016.
20160276
Inaba Y, Motobayashi M, Nishioka M, Kaneko
T, Yamauchi S, Kawasaki Y, Shiba N, Nishio S, Moteki H,
Miyagawa M, Takumi Y, Usami S, Koike K : Correlation
between White Matter Lesions and Intelligence Quptient inpatients with Congenital Cytomegalovirus Infection. Pediatr
Neurol 55: 52-57, 2016.
20160277
Kitoh R, Moteki H, Nishio S, Shinden S,
Kanzaki S, Iwasaki S, Ogawa K, Usami S : The effects ofcochlear implantation in Japanese single-sided deafness
patients: five case reports. Acta Otolaryngol 136: 460-464,
2016.
20160278
Kitoh R, Nishio S, Ogawa K, Okamura M
Kitamura K, Gyo K, Sato H, Nakashima T, Fukuda S,
Fukushima K, Hara A, Yamasoba T, Usami S : SOD1 gene
polymorphisms in sudden sensorineural hearing loss. Acta
Otolaryngol 136: 465-469, 2016.

Ophthalmology

20160279
Miyagawa M, Nishio S, Usami S : A
Comprehensive Study on the Etiology of Patients Receiving
Cochlear Implantation With Special Emphasis on Genetic
Epidemiology. Otol Neurotol 37(2): e126-e134, 2016.

20160271
Iesato Y, Imai A, Hirano T, Toriyama Y, Murata
T : Effect of leaking capillaries and microaneurysms in theperifoveal capillary network on resolution of macular edemaby anti-vascular endothelial growth factor treatment. Jpn J
Ophthalmol 60: 86-94, 2016.

20160280
Sakuma N, Moteki H, Takahashi M, Nishio
S, Arai Y, Yamashita Y, Oridate N, Usami S : An effective
screening strategy for deafness in combination with a nextgeneration sequencing platform: a consecutive analysis. J
Hum Genet 61(3): 253-261, 2016.

20160272
Iesato Y, Yuda K, Chong KT, Tan X, Murata
T, Shindo T, Yanagi Y : Adrenomedullin: A potential
therapeutic target for retinochoroidal disease. Prog Retin Eye
Res 52: 112-129, 2016.

20160281
Moteki H, Azaiez H, Booth K.T, Shearer A.E,
Sloan C.M, Kolbe D.L, Nishio S, Hattori M, Usami S, Smith
R.J.H : Comprehensive genetic testing with ethnic-specificfiltering by allele frequency in a Japanese hearing-loss
population. Clin Genet 89: 466-472, 2016.

20160273
Tokimitsu M, Murata M, Toriyama Y, Hirano
T, Iesato Y, Murata T : Delineation of capillary dropout inthe deep retinal capillary plexus using optical coherence
tomography angiography in a patient with Purtscher's
retinopathy exhibiting normal fluorescein angiography
findings: a case report. BMC Ophthalmol 16: 113, 2016.

20160282
Karino S, Usami S, Kumakawa K, Takahashi H,
Tono T, Naito Y, Doi K, Ito K, Suzuki M, Sakata H, Takumi
Y, Iwasaki S, Kakigi A, Yamasoba T : Discrimination ofJapanese monosyllables in patients with high-frequency
hearing loss. Auris Nasus Larynx 43: 269-280, 2016.

20160274
Stewart MW, Landers MB, Murata T, Ohji M,
Nawrocki J, Chhablani JK : Correspondence. Retina 36:

20160283
Moteki H, Azaiez H, Sloan-Heggen CM,
Booth K, Nishio S, Wakui K, Yamaguchi T, Kolbe DL,

20

Iwasa Y, Shearer AE, Fukushima Y, Smith RJ, Usami S :Detection and Confirmation of Deafness-Causing Copy
Number Variations in the STRC Gene by Massively Parallel
Sequencing and Comparative Genomic Hybridization. Ann
Otol Rhinol Laryngol 125: 918-923, 2016.
20160284
Mori K, Moteki H, Miyagawa M, Nishio SY,
Usami S : Social Health Insurance-Based Simultaneous
Screening for 154 Mutations in 19 Deafness Genes
Efficiently Identified Causative Mutations in Japanese
Hearing Loss Patients. PLoS One 11(9): e0162230, 2016.
20160285
Ueyama T, Ninoyu Y, Nishio S, Miyoshi T,
Torii H, Nishimura K, Sugahara K, Sakata H, Thumkeo D,
Sakaguchi H, Watanabe N, Usami S, Saito N, Kitajiri S :Constitutive activation of DIA1 (DIAPH1) via C-terminal
truncation causes human sensorineural hearing loss. EMBO
Mol Med 8(11): 1310-1324, 2016.
20160286
Iwasa Y, Nishio S, Usami S : Comprehensive
Genetic Analysis of Japanese Autosomal DominantSensorineural Hearing Loss Patients. PLoS One 11(12):e0166781, 2016.

Obstetrics and Gynecology
20160287
Norihiko Kikuchi, Satoshi Ohira, Ryoichi
Asaka, Akiko Takatsu, Hisanori Kobara, Hirofumi Ando,
Makoto Kanai, Tsutomu Miyamoto, Tanri Shiozawa : A caseof vaginal varices that caused massive bleeding after vaginal
delivery. Shinshu Medical Journal 64: 35-39, 2016.
20160288
Yasushi Yamada, Satoshi Ohira, Teruyuki
Yamazaki, Tanri Shiozawa : Ectopic molar pregnancy:
diagnostic efficacy of magnetic resonance imaging andreview of the literature. Case Rep Obstet Gynecol 2016:
7618631, 2016.
20160289
Norihoko Kikuchi, Satoshi Ohira, Ryoichi
Asaka, Kyoko Tanaka, Akiko Takatsu, Tanri Shiozawa :Prenatal sonographic diagnosis of fetal valproate syndrome:a case report. J Med Case Rep 10: 312, 2016.
20160290
Yasushi Yamada, Tsutomu Miyamoto, Hiroyasu
Kashima, Hisanori Kobara, Ryoichi Asaka, Hirofumi
Ando,Shotaro Higuchi, Koichi Ida ,Tanri Shiozawa :Lipocalin 2 attenuates iron-related oxidative stress andprolongs the survival of ovarian clear cell carcinoma cells by
up-regulating the CD44 variant. Free Radic Res 50(4): 414425, 2016.
20160291
Miyamoto T, Kashima H, Yamada Y, Kobara H,
Asaka R, Ando H, Higuchi S, Ida K, Mvunta DH, Shiozawa

T : Lipocalin 2 Enhances Migration and ResistanceagainstCisplatin in Endometrial Carcinoma Cells. PLoS One
11(5): e0155220, 2016.
20160292
Hirofumi Ando, Tsutomu Miyamoto, Hiroyasu
Kashima, Akiko Takatsu, Keiko Ishii, Yasunari Fujinaga,
Tanri Shiozawa : Usefulness of a management protocol forpatients with cervical multicystic lesions: A retrospective
analysis of 94 cases and the significance of GNAS mutation.
J Obstet Gynaecol Res 42(11): 1588-1598, 2016.

Anesthesiology and Resuscitology
20160293
Sakamoto A, Takayama Y, Mamiya K, Koizumi
T : Opioid withdrawal presenting only nausea during
tapering of Oxycodone after celiac plexus block: a casereport. Ann Palliat Med 5: 67-70, 2016.
20160294
Ishida T, Tanaka S, Sekiguchi T, Sugiyama
D, Kawamata M : Spinal nociceptive transmission bymechanical stimulation of bone marrow. Mol Pain 12:1744806916628773, 2016.
20160295
Yoshiyama Y, Sugiyama Y, Ide S, Fuseya
S, Murakami T, Kawamata M : Efficacy of Temporary
Transvenous Pacing to Prevent Atropine-resistant
Bradycardia during Surgery for a Tumor in the Brainstem
Region: A Case Report. Shinshu Medical Journal 64: 153157, 2016.
20160296
Fuseya S, Yamamoto K, Minemura H, Yamaori
S, Kawamata T, Kawamata M : Systemic QX-314 Reduces
Bone Cancer Pain through Selective Inhibition of Transient
Receptor Potential Vanilloid Subfamily 1–expressing
Primary Afferents in Mice. Anesthesiology 125: 204-218,
2016.
20160297
Kozuka Y, Kawamata M, Furue H, Ishida T,
Tanaka S, Namiki A, Yamakage M : Changes in synaptictransmission of substantia gelatinosa neurons after spinal
cord hemisection revealed by analysis using in vivo patchclamp recording. Mol Pain 12: 1744806916665827, 2016.
20160298
Tanaka Y, Kawaguchi M, Noguchi Y, Yoshitani
K, Kawamata M, Masui K, Nakayama T, Yamada Y :Systematic review of motor evoked potentials monitoring
during thoracic and thoracoabdominal aortic aneurysm open
repair surgery: a diagnostic meta-analysis. J Anesth 30:
1037-1050, 2016.

Laboratory Medicine
20160299

Shigeto S, Matsuda K, Yamaguchi A, Sueki21

A, Uehara M, Sugano M,Uehara T, Honda T : Rapid
diagnosis of acute promyelocytic leukemia with the PMLRARA fusion gene using a combination of droplet-reverse
transcription-polymerase chain reaction and instant-quality
fluorescence in situ hybridization. Clin Chim Acta 453:
38-41, 2016.
20160300
Nakajima T, Uehara T, Maruyama Y, Iwaya M,
Kobayashi Y, Ota H : Distribution of Lgr5-positive cancer
cells in intramucosal gastric signet-ring cell carcinoma.
Pathol Int 66: 518-523, 2016.
20160301
Negishi T, Matsumoto T, Saito S, Kasuga E,
Horiuchi K, Natori T, Takehara K, Sugano M, Honda T :Catheter-Related Bacteremia Due to Gordonia sputi in a
Patient with Acute Lymphocytic Leukemia: a Case Report.
Jpn J Infect Dis 69: 342-343, 2016.
20160302
Tokoro Y, Yasuo M, Kobayashi T, Hama M,
Ichiyama T, Horiuchi T, Ushiki A, Kawakami S, Honda T,
Hanaoka M : Computed tomography-guided bronchoscopy
in the diagnosis of small peripheral pulmonary lesions: A
retrospective study of 240 examinations in a single academic
center. Respir Investig 54: 347-354, 2016.
20160303
Matsumoto T, Negishi T, Hamada M, Komaki
H, Gonoi T, Yaguchi T : Nocardia shinanonensis sp. nov.,
isolated from a patient with endophthalmitis. Int J Syst Evol
Microbiol 66: 3324-3328, 2016.
20160304
Mukai S, Nagata K, Ikeda M, Arai S, Sugano
M, Honda T, Okumura N : Genetic analyses of novelcompound heterozygous hypodysfibrinogenemia, Tsukuba
I: FGG c.1129+62_65 del AATA and FGG c.1299+4 del A.
Thromb Res 148: 111-117, 2016.
20160305
Kobayashi M, Yamamoto K, Ogiwara N,
Matsumoto T, Shigeto S, Ota H : Helicobacter heilmanniilike organism in parietal cells: A diagnostic pitfall. Pathol Int
66: 120-122, 2016.
20160306
Hoshino H, Ohta M, Ito M, Uchimura K, Sakai
Y, Uehara T, Low S, Fukushima M, Kobayashi M : Apicalmembrane expression of distinct sulfated glycans represents
a novel marker of cholangiolocellular carcinoma. Lab Invest
96: 1246-1255, 2016.
20160307
Zhang M, Yoshizawa A, Kawakami S, Asaka S,
Yamamoto H, Yasuo M, Agatsuma H, Toishi M, Shiina T,
Yoshida K, Honda T, Ito KI : The histological characteristics
and clinical outcomes of lung cancer in patients withcombined pulmonary fibrosis and emphysema. Cancer Med
5(10): 2721-2730, 2016.

20160308
Yasuo M, Kobayashi T, Hama M, Ichiyama
T, Horiuchi T, Yamamoto H, Kawakami S, Hamanaka
K, Honda T, Hanaoka M : Combination of virtual
bronchoscopic navigation with conventional transbronchialneedle aspiration in the diagnosis of peribronchial
pulmonary lesions located in the middle third of the lungs.
Respir Investig 54(5): 355-363, 2016.
20160309
Honda T, Uehara T, Matsumoto G, Arai S,
Sugano M : Neutrophil left shift and white blood cell countas markers of bacterial infection. Clin Chim Acta 457:
46-53, 2016.
20160310
Yamaguchi A, Matsuda K, Uehara M, Honda
T, Saito Y : A novel automated device for rapid nucleic acidextraction utilizing a zigzag motion of magnetic silica beads.
Anal Chim Acta 906: 1-6, 2016.
20160311
Sueki A, Matsuda K, Yamaguchi A, Uehara
M, Sugano M, Uehara T, Honda T : Evaluation of saliva as
diagnostic materials for influenza virus infection by PCRbased assays. Clin Chim Acta 453: 71-74, 2016.
20160312
Hori A, Yamashita M, Yamaura M, Hongo M,
Honda T, Hidaka H : Rapid quantitative analysis of humanserum sphingomyelin species using MALDI-TOF mass
spectrometry with lipid hydrolase treatment. Clin Chim Acta
453: 95-99, 2016.
20160313
A s h i h a r a N , N a k a j i m a K , N a k a m u r a Y,
Kobayashi M, Shirahata K, Maeda C, Uehara T, Gomi
D, Ito N : Denosumab is Effective for Controlling Serum
Calcium Levels in Patients with Humoral Hypercalcemiaof Malignancy Syndrome: A Case Report on Parathyroid
Hormone-related Protein-producing Cholangiocarcinoma.
Intern Med 55(23): 3453-3457, 2016.
20160314
Shigemura T, Ohno Y, Sano K, Uehara T,
Terada M, Koike K, Nakazawa Y : Gangrenous appendicitis
in a patient with severe congenital neutropenia. Pediatr Int
58(10): 1093-1094, 2016.
20160315
H a n a m u r a T, I t o T, K a n a i T, M a e n o K ,Shimojo Y, Uehara T, Suzuki T, Hayashi S, Ito K : Human
3β-hydroxysteroid dehydrogenase type 1 in human breast
cancer: clinical significance and prognostic associations.
Cancer Med 5(7): 1405-1415, 2016.
20160316
Komori K, Yanagisawa R, Miyairi Y, Sakashita
K, Shiohara M, Fujihara I, Morita D, Nakamura T, Ogiso Y,
Sano K, Shirahata M, Fukuoka K, Ichimura K, Shigeta H :Temozolomide Treatment for Pediatric Refractory Anaplastic
Ependymoma With Low MGMT Protein Expression. Pediatr

22

Blood Cancer 63(1): 152-155, 2016.
20160317
Tatai T, Gomi D, Fukushima T, Kobayashi T,
Sekiguchi N, Sakamoto A, Sasaki S, Koizumi T, Sano K :Effectiveness of Imatinib Mesylate Treatment in a Patientwith Dermatofibrosarcoma Protuberans with Pulmonary andPancreatic Metastases. Intern Med 55(17): 2507-2511, 2016.
20160318
Al-Kzayer LF, Keizer P, Abdulraheem FT, Sano
K, Kamata M, Sakashita K, Habbaba LA, Koike K : Rapidly
progressive Kaposi's Sarcoma in an Iraqi boy received
Valproic acid: a case report and review of literature. BMC
Pediatr 16: 111, 2016.
20160319
Yoshimura Y, Sano K, Isobe K, Aoki K, Kito M,
Kato H : A recurrent solitary fibrous tumor of the thigh withmalignant transformation: A case report. Int J Surg Case Rep
21: 111-114, 2016.
20160320
Hirabayashi K, Yamauchi S, Matsuzaki S,
Komatsu K, Sano K, Koike K, Nakazawa Y : Anaplastic
Large-Cell Lymphoma of the Left Ventricle Presenting With
Arrhythmia and Cerebral Infarction due to Cardiogenic
Embolism. Pediatr Blood Cancer 63(4): 755-756, 2016.
20160321
Yanagisawa R, Noguchi M, Fujita K, Sakashita
K, Sano K, Ogiso Y, Katsuyama Y, Kondo Y, Komori
K, Fujihara I, Kitamura R, Hiroma T, Nakamura T :Preoperative Treatment With Pazopanib in a Case of
Chemotherapy-Resistant Infantile Fibrosarcoma. Pediatr
Blood Cancer 63(2): 348-351, 2016.
20160322
Fujimori N, Tanaka N, Shibata S, Sano K,
Yamazaki T, Sekiguchi T, Kitabatake H, Ichikawa Y, Kimura
T, Komatsu M, Umemura T, Matsumoto A, Tanaka E :Controlled attenuation parameter is correlated with actual
hepatic fat content in patients with non-alcoholic fatty liverdisease with none-to-mild obesity and liver fibrosis. Hepatol
Res 46(10): 1019-1027, 2016.
20160323
Yoshimoto A, Ohkawa R, Yano K, Sato M,
Ichimura N, Usami Y, Miyazaki A, Sugano M, Uehara T,
Tozuka M : Paraoxonase 1 associated with high-density
lipoprotein transfers to oxidized low-density lipoprotein
depending on the degree of oxidation. Int J Anal Bio-Sci
4(4): 99-109, 2016.
20160324
Kato A, Yamamoto H, Ikeda M, Tateishi K,
Ushiki A, Yasuo M, Kawakami S, Asaka S, Oguchi K,
Hanaoka M : A case of pulmonary Mycobacterium avium
infection in an immunocompetent patient who showed ahuge consolidation with a high FDG uptake on PET/CT.
Respir Med Case Rep 19: 49-52, 2016.

20160325
Uehara M, Hanamura M, Yamada K, YamaguchiA, Murayama T, Saito Y, Idegami K, Honda T : A Rapid andAutomated Device for Purifying Nucleic Acids. Anal Sci
32(3): 371-374, 2016.
20160326
Shigemura T, Nishina S, Nakazawa H, Matsuda
K, Yaguchi T, Nakazawa Y : Early detection of Rhizopus
DNA in the serum of a patient with rhino-orbital-cerebral
mucormycosis following allogeneic hematopoietic stem celltransplantation. Int J Hematol 103(3): 354-355, 2016.
20160327
Nakazawa Y, Matsuda K, Kurata T, Sueki A,
Tanaka M, Sakashita K, Imai C, Wilson MH, Koike K :Anti-proliferative effects of T cells expressing a ligandbased chimeric antigen receptor against CD116 on CD34(+)
cells of juvenile myelomonocytic leukemia. J Hematol
Oncol 9: 27, 2016.
20160328
Ta n a h a s h i T, S e k i g u c h i N , M a t s u d a K ,Takezawa Y, Ito T, Kobayashi H, Ichikawa N, Nishina
S, Senoo N, Sakai H, Nakazawa H, Ishida F : Cellsize variations of large granular lymphocyte leukemia:
Implication of a small cell subtype of granular lymphocyte
leukemia with STAT3 mutations. Leuk Res 45: 8-13, 2016.
20160329
Sakashita K, Matsuda K, Koike K : Diagnosis
and treatment of juvenile myelomonocytic leukemia. Pediatr
Int 58(8): 681-690, 2016.
20160330
Andersson EI, Tanahashi T, Sekiguchi N,
Gasparini VR, Bortoluzzi S, Kawakami T, Matsuda K,
Mitsui T, Eldfors S, Bortoluzzi S, Coppe A, Binatti A,
Lagström S, Ellonen P, Fukushima N, Nishina S, Senoo
N, Sakai H, Nakazawa H, Kwong YL, Loughran TP,
Maciejewski JP, Mustjoki S, Ishida F : High incidence ofactivating STAT5B mutations in CD4-positive T-cell large
granular lymphocyte leukemia. Blood 128(20): 2465-2468,
2016.
20160331
Hirabayashi K, Kurata T, Horiuchi K, Saito
S, Shigemura T, Tanaka M, Yanagisawa R, Matsuda K,
Sakashita K, Koike K, Nakazawa Y : Loss of Mismatched
HLA on the Leukemic Blasts of Patients With Relapsed
Ly m p h o i d M a l i g n a n c i e s F o l l o w i n g B o n e M a r r o w
Transplantation From Related Donors With HLA Class II
Mismatches in the Graft Versus Host Direction. Pediatr
Blood Cancer 63(4): 709-711, 2016.

Emergency and Critical Care Medicine
20160332
Mochizuki K, Hamano Y, Miyama H, Arakawa
K, Kobayashi T, Imamura H : Successful treatment of a casewith concurrent ingestion of carbamazepine overdose and23

grapefruit juice. Acute Med Surg 3: 36-38, 2016.
20160333
Nitta K, Hamano Y, Kamijo H, Oishi S,
Ichikawa M, Takayama H, Mochizuki K, Agatsuma H,
Imamura H : Complete cervical tracheal transection due toblunt trauma. Acute Med Surg 3: 376-379, 2016.

20160341
Ashida A, Ogawa E, Uhara H, Koizumi T,
Okuyama R : Inhibition of epidermal growth factor receptor
induces tumor necrosis factor-α via activation of peroxisome
proliferator-activated receptor-γ and nuclear factor-κB in
sebocytes: A possible pathogenesis of papulopustular rash. J
Dermatol Sci 82(1): 53-56, 2016.

20160334
Nitta K, Imamura H, Yashio A, Takeshige K,
Tsukada M, Ippongi K, Mochizuki K, Kashima Y, Sugiyama
S, Miyagawa S : Rupture of gastrointestinal stromal tumor
presenting with sudden onset chest and back pain andaccompanied by gastric dilatation. Acute Med Surg 3: 380383, 2016.

20160342
Booka E, Imamura C, Takeuchi H, Hamamoto
Y, Gomi D, Mizukami T, Ichiyama T, Tateishi K, Takahashi
T, Kawakubo H, Soejima K, Boku N, Tanigawara Y,
Kitagawa Y : Development of an S-1 dosage formula basedon renal function by a prospective pharmacokinetic study.
Gastric Cancer 19(3): 876-886, 2016.

20160335
Nitta K, Imamura H, Yashio A, Kashima Y,
Mochizuki K : Diffuse Alveolar Hemorrhage Associatedwith Edoxaban Therapy. Case Rep Crit Care 2016: 7938062,
2016.

20160343
Gomi D, Sasaki S, Sekiguchi N, Kobayashi
T, S a k a m o t o A , K o i z u m i T : A C a s e o f O l f a c t o r y
Neuroblastoma (Esthesioneuroblastoma) Presenting with
Anemia Due to Nasal Bleeding. Shinshu Med J 64(5): 247252, 2016.

20160336
Miyazaki D, Fukushima K, Nakahara A,
Kodaira M, Mochizuki K, Kaneko K, Kaneko T, Sekijima
Y, Ikeda S : Crossed Cerebellar Diaschisis in Status
Epilepticus. Intern Med 55: 1649-1651, 2016.
20160337
Minamisawa M, Motoki H, Izawa A, Kashima
Y, Hioki H, Abe N, Miura T, Ebisawa S, Miyashita
Y, Koyama J, Ikeda U : Comparison of Inflammatory
Biomarkers in Outpatients With Prior Myocardial Infarction.
Int Heart J 57: 11-17, 2016.
20160338
Hioki H, Motoki H, Izawa A, Kashima Y, MiuraT, Ebisawa S, Tomita T, Miyashita Y, Koyama J, Ikeda U: Impact of oral beta-blocker therapy on mortality after
primary percutaneous coronary intervention for Killip class
1 myocardial infarction.. Heart Vessels 31: 687-693, 2016.
20160339
Okada A, Kashima Y, Tomita T, Takeuchi
T, Aizawa K, Takahashi M, Ikeda U : Characterizationof cardiac oxidative stress levels in patients with atrial
fibrillation. Heart Vessels 31: 80-87, 2016.

Comprehensive Cancer Therapy
20160340
Andersson EI, Tanahashi T, Sekiguchi N,
Gasparini VR, Bortoluzzi S, Kawakami T, Matsuda K,
Mitsui T, Eldfors S, Bortoluzzi S, Coppe A, Binatti A,
Lagström S, Ellonen P, Fukushima N, Nishina S, Senoo
N, Sakai H, Nakazawa H, Kwong YL, Loughran TP,
Maciejewski JP, Mustjoki S, Ishida F : High incidence ofactivating STAT5B mutations in CD4-positive T-cell large
granular lymphocyte leukemia. Blood 128(20): 2465-2468,
2016.

20160344
Koiwai K, Sasaki S, Yoshizawa E, Ina H,
Fukazawa A, Sakai K, Ozawa T, Matsushita H, Kadoya M :Palliative radiotherapy for Japanese patients with malignant
melanoma: a single-institution experience. Jpn J Radiol
34(2): 125-129, 2016.
20160345
Koizumi T, Fukushima T, Gomi D, Kobayashi
T, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K :Alectinib-Induced Alopecia in a Patient with Anaplstic
Lymphoma Kinase-Positive Non-Small Cell Lung Cancer.
Case Rep Oncol 9: 212-215, 2016.
20160346
Morita D, Nakazawa Y, Tanaka M, Nakayama Y,
Koizumi T, Koike K : Early-onset colorectal cancer in young
adult survivors of childhood cancer. Pediatr Int 58(7): 637639, 2016.
20160347
Ohue Y, Matsuoka S, Kumeda H, Agatsuma
H, Hyougotani A, Toishi M, Shiina T, Yoshida K, Shingu
K, Fukushima T, Koizumi T : Development of combined
thymic carcinoma and thymoma in an extrathymic lesion
during long follow-up for recurrent thymoma. Mol Clin
Oncol 4(2): 139-142, 2016.
20160348
Okada N, Fujii C, Matsumura T, Kitazawa M,
Okuyama R, Taniguchi S, Hida S : Novel role of ASC as aregulator of metastatic phenotype. Cancer Med 5(9): 24872500, 2016.
20160349
Sakamoto A, Takayama H, Mamiya K, Koizumi
T : Opioid withdrawal presenting only nausea during
tapering of oxycodone after celiac plexus block: a casereport. Ann Palliat Med 5(1): 67-70, 2016.

24

20160350
Ta n a h a s h i T, S e k i g u c h i N , M a t s u d a K ,Takezawa Y, Ito T, Kobayashi H, Ichikawa N, Nishina
S, Senoo N, Sakai H, Nakazawa H, Ishida F : Cellsize variations of large granular lymphocyte leukemia:
Implication of a small cell subtype of granular lymphocyte
leukemia with STAT3 mutations. Leuk Res 45: 8-13, 2016.
20160351
Tanaka M, Koyama T, Sakurai T, Kamiyoshi
A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A,
Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K,
Taniguchi S, Shindo T : The endothelial adrenomedullinRAMP2 system regulates vascular integrity and suppresses
tumour metastasis. Cardiovasc Res 111(4): 398-409, 2016.
20160352
Tatai T, Gomi D, Fukushima T, Kobayashi T,
Sekiguchi N, Sakamoto A, Sasaki S, Koizumi T, Sano K :Effectiveness of Imatinib Mesylate Treatment in a Patientwith Dermatofibrosarcoma Protuberans with Pulmonary andPancreatic Metastases. Intern Med 55(17): 2507-2511, 2016.
20160353
Tokoro Y, Yasuo M, Kobayashi T, Hama M,
Ichiyama T, Horiuchi T, Ushiki A, Kawakami S, Honda T,
Hanaoka M : Computed tomography-guided bronchoscopy
in the diagnosis of small peripheral pulmonary lesions: A
retrospective study of 240 examinations in a single academic
center. Respir Investig 54(5): 347-354, 2016.
20160354
Yasuo M, Kobayashi T, Hama M, Ichiyama
T, Horiuchi T, Yamamoto H, Kawakami S, Hamanaka
K, Honda T, Hanaoka M : Combination of virtual
bronchoscopic navigation with conventional transbronchialneedle aspiration in the diagnosis of peribronchial
pulmonary lesions located in the middle third of the lungs.
Respir Investig 54(5): 355-363, 2016.
20160355
Wada Y, Koyama S, Kuraishi H, Miyahara
T, Yoshiike F, Agatsuma T, Yamamoto R, Ono Y, Suzuki
T, Hachiya T, Gomi D, Tateishi K, Hanaoka M, Koizumi
T : Clinical analysis of patients treated with afatinib foradvanced non-small cell lung cancer: A Nagano Lung
Cancer Research Group observational study. Respir Investig
54(6): 462-467, 2016.

Brain Disease Research
20160356
Inden M, Iriyama M, Zennami M, Sekine S,
Hara A, Yamada M, Hozumi I : The type III transporters(PiT-1 and PiT-2) are the major sodium-dependent phosphatetransporters in the mice and human brains. Brain Res 1637:
128-136, 2016.
20160357
Hokari M, Yokoseki A, Arakawa M, Saji E,
Yanagawa K, Yanagimura F, Toyoshima Y, Okamoto K,

Ueki S, Hatase T, Ohashi R, Fukuchi T, Akazawa K, Yamada
M, Kakita A, Takahashi H, Nishizawa M, Kawachi I :Clinicopathological features in anterior visual pathway inneuromyelitisoptica. Ann Neurol 79: 605-624, 2016.
20160358
Ya m a d a M , To y o s h i m a Y, M a k i f u c h i T,
Kakita A, Takahashi H : Spinocerebellar degeneration:
Discrepancies between clinical and pathological diagnoses.
Neuropathology 36: 405-410, 2016.
20160359
Sekijima Y, Yazaki M, Oguchi K, Ezawa N,
Yoshinaga T, Yamada M, Yahikozawa H, Watanabe M,
Kametani F, Ikeda S : Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis.
Neurology 87: 773-781, 2016.
20160360
Onozato T, Nakahara A, Suzuki-Kouyama E,
Hineno A, Yasude T, Nakamura T, Yahikozawa H, Watanabe
M, Kayanuma K, Makishita H, Ohara S, Hashimoto T,
Higuchi K, Sakai T, Asano K, Hashimoto T, Kanno H,
Nakayama J, Oyanagi K : Axonal TDP-43 aggregates insporadic amyotrophic lateral sclerosis. Neuropathol Appl
Neurobiol 42: 561-572, 2016.
20160361
Kondo Y, Kinoshita M, Yoshida T, Matoba H,
Uehara T, Ikeyama M, Nakayama J, Yoshida K, Ikeda S :Unexpected occurrence of fetal hemophagocytic syndrome
in a patient with hereditary diffuse leukoencephalopathy
with spheroids. Case Rep Clin Med 5: 77-84, 2016.
20160362
Miyazaki D, Nakamura A, Hineno A, Kobayashi
C, Kinoshita T, Yoshida K, Ikeda S : Elevation of serum
heat-shock protein levels in amyotrophic lateral sclerosis.
Neurol Sci 37: 1277-1281, 2016.
20160363
Oyanagi K, Yamada M, Hineno A, Yahikozawa
H, Ushiyama M, Miki J, Kanno H, Nakayama J, Makishita
H, Inoue K, Ohara S, Hayashida K, Kayanuma K,
Yamamoto K, Yasude T, Hashimoto T, Yoshida K, Ikeda S :Shinshu Brain Resource Net. Neuropathology 36: 600-601,
2016.

Neonatology
20160364
Motobayashi M, Nishimura T, Inaba Y :Usefulness of Circulating B-cell-Activating Factor Serial
Monitoring in Childhood-Onset Ocular Myasthenia Gravis.
Pediatr Neurol 63: e1-e2, 2016.
20160365
Motobayashi M, Morita D, Kurata T, Shigemura
T, Nakazawa Y, Shimozawa N, Inaba Y : Serial Monitoringof Plasma Levetiracetam Levels in a Child With Epilepsy
Undergoing Cord Blood Transplantation. Pediatr Neurol 64:

25

e5-e6, 2016.
20160366
Morita D, Hirabayashi K, Katsuyama Y,
Morokawa H, Motobayashi M, Kurata T, Shigemura T,
Tanaka M, Inaba Y, Koike K, Nakazawa Y : Viral loadand ganciclovir (GCV) concentration in cerebrospinal
fluid of patients successfully treated with GCV or valGCV
for human herpesvirus 6 encephalitis/myelitis following
umbilical cord blood transplantation. Transpl Infec Dis 18:
773-776, 2016.
20160367
A k a z a w a Y, H a c h i y a A , Ya m a z a k i S ,Kawasaki Y, Nakamura C, Takeuchi Y, Kusakari M,
Miyosawa Y, Kamiya M, Motoki N, Koike K, Nakamura
T : Cardiovascular Remodeling and Dysfunction
Across a Range of Growth Restriction Severity in Small
for Gestational Age Infants - Implications for Fetal
Programming. Circ J 80: 2212-2220, 2016.
20160368
Akazawa Y, Motoki N, Tada A, Yamazaki S,
Hachiya A, Matsuzaki S, Kamiya M, Nakamura T, Kosho
T, Inaba Y : Decreased Aortic Elasticity in Children With
Marfan Syndrome or Loeys-Dietz Syndrome. Circ J 80:
2369-2375, 2016.

T : Preoperative Treatment With Pazopanib in a Case of
Chemotherapy-Resistant Infantile Fibrosarcoma. Pediatr
Blood Cancer 63: 348-351, 2016.
20160374
Komori K, Yanagisawa R, Miyairi Y, Sakashita
K, Shiohara M, Fujihara I, Morita D, Nakamura T, Ogiso Y,
Sano K, Shirahata M, Fukuoka K, Ichimura K, Shigeta H :Temozolomide Treatment for Pediatric Refractory Anaplastic
Ependymoma with Low MGMT Protein Expression. Pediatr
Blood Cancer 63: 152-155, 2016.

Occupational Health20160375
Tsukahara T, Arai H, Kamijo T, Kobayashi Y,
Washizuka S, Arito H, Nomiyama T : Relationships between
suicidal ideation and psychosocial factors among residents
living in Nagano Prefecture of Japan. Environ Health Prev
Med 21(3): 164-172, 2016.
20160376
Tsukahara T, Miyauchi H, Kuwada d, Kikuchi
T, Tsuda Y, Yanagiba Y, Arito H, Nomiyama T : Control
banding assesment of exposure of offset printing workers toorganic solvents. J Occup Health 58(3): 314-319, 2016.

20160369
Hiroma T, Ichiba H, Wada K, Shiraishi J,
Sugiura H, Nakamura T : Nationwide survey of neonataltransportation practices in Japan. Pediatr Int 58: 311-313,
2016.

20160377
Hyakutake A, Kamijo T, Misawa Y, Washizuka
S, Inaba Y, Tsukahara T, Nomiyama T : Cross-sectional
observation of the relationship of depressive symptoms withlifestyles and parents' status among Japanese junior highschool students. Environ Health Prev Med 21(4): 265-273,
2016.

20160370
Nakamura T, Yonemoto N, Nakayama M,
Hirano S, Aotani H, Kusuda S, Fujimura M, Tamura
M; and The Neonatal Research Network, Japan : Early
inhaled steroid use in extremely low birthweight infants: arandomised controlled trial. Arch Dis Child Fetal Neonatal
Ed 101: F552-F556, 2016.

20160378
Tsuda Y, Otsuka T, Tsukahara T, Nomiyama T :Measurement of fluoride in human urine by headspace gas
chromatography-mass spectrometer. Biomedical research on
trace elements 27(1): 15-22, 2016.

20160371
Inaba Y, Motobayashi M, Nishioka M, Kaneko
T, Yamauchi S, Kawasaki Y, Shiba N, Nishio SY, Moteki H,
Miyagawa M, Takumi Y, Usami S, Koike K : Correlation
Between White Matter Lesions and Intelligence Quotient inPatients With Congenital Cytomegalovirus Infection. Pediatr
Neurol 55: 52-57, 2016.
20160372
Yanagisawa R, Shimodaira S, Sakashita K,
Hidaka Y, Kojima S, Nishijima F, Hidaka E, Shiohara M,
Nakamura T : Factors related to allergic transfusion reactions
and febrile non-haemolytic transfusion reactions in children.
Vox Sang 110: 376-384, 2016.
20160373
Ya n a g i s a w a R , N o g u c h i M , F u j i t a K ,Sakashita K, Sano K, Ogiso Y, Katsuyama Y, Kondo Y,
Komori K, Fujihara I, Kitamura R, Hiroma T, Nakamura

20160379
Tsukahara T, Arai H, Kamijo T, Kobayashi
Y, Washizuka S, Arito H, Nomiyama T : The relationshipbetween attitudes toward suicide and family history ofsuicide in Nagano Prefecture, Japan. Int J Environ Res
Public Health 13(6): E623, 2016.
20160380
The committee for recommendationof occupational exposure limits, Japan Society for
Occupational Health; Azuma K, Endo G, Endo Y, Hara K,
HaradaK, Hori H, Horie S, Horiguchi H, Ichiba M, Ichihara
G, Ikeda M, Ishitake G, Ito A, Iwasawa S, Kamijima M,
Karita K, Nasu T, Nomiyama T, Omae K, Sato K, Okuda
H, Sakurai H, Sobue T, Suwazono Y, Takebayashi T,
Takeshita T, Takeuchi A, Tanaka M, Tanaka S, Tsukahara
T, Tsunoda M, Ueno S, Yamano Y, Yamauchi T, Yano E.
: Occupational exposure limits of lead, dimethylamine,
n-butyl-2,3-epoxypropyl ether, and 2-ethyl-1-hexanol and26

carcinogenicity and occupational sensitizer classification. J
Occup Health 58(4 spec iss): 385-387, 2016.

Hearing Implant Sciences
20160381
Noguchi Y, Takahashi M, Ito T, Fujikawa
T, Kawashima Y, Kitamura K : Delayed restoration of
maximum speech discrimination scores in patients with
idiopathic sudden sensorineural hearing loss. Auris Nasus
Larynx 43: 495-500, 2016.
20160382
Yoshimura H, Miyagawa M, Kumakawa K,
Nishio S, Usami S : Frequency of Usher syndrome type 1 indeaf children by massively parallel DNA sequencing. J Hum
Genet 61: 419-422, 2016.
20160383
Miyagawa M, Nishio S, Usami S : A
Comprehensive Study on the Etiology of Patients Receiving
Cochlear Implantation With Special Emphasis on Genetic
Epidemiology. Otol Neurotol 37(2): e126-e134, 2016.
20160384
Karino S, Usami S, Kumakawa K, Takahashi H,
Tono T, Naito Y, Doi K, Ito K, Suzuki M, Sakata H, Takumi
Y, Iwasaki S, Kakigi A, Yamasoba T : Discrimination ofJapanese monosyllables in patients with high-frequency
hearing loss. Auris Nasus Larynx 43: 269-280, 2016.
20160385
Mori K, Moteki H, Miyagawa M, Nishio SY,
Usami S : Social Health Insurance-Based Simultaneous
Screening for 154 Mutations in 19 Deafness Genes
Efficiently Identified Causative Mutations in Japanese
Hearing Loss Patients. PLoS One 11(9): e0162230, 2016.

Center for Medical Education and ClinicalTraining
20160386
Tokutake T, Baba H, Shimada Y, Takeda W,
Sato K, Hiroshima Y, Kirihara T, Shimizu I, Nakazawa H,
Kobayashi H, Ishida F : Exogenous Magnesium Chloride
Reduces the Activated Partial Thromboplastin Times of
Lupus Anticoagulant-Positive Patients. PLoS One 11(6):e0157835, 2016.

Aging Biology
20160387
Yoshinaga T, Yazaki M, Sekijima Y, Kametani
F, Miyashita K, Hachiya N, Tanaka T, Kokudo N, Higuchi
K, Ikeda S : The pathological and biochemical identificationof possible seed-lesions of transmitted transthyretin
amyloidosis after domino liver transplantation. J Pathol Clin
Res 2: 72-79, 2016.
20160388

Liu Y, Sawashita J, Wang Y, Li L, Miyahara H,

Ding X, Yang M, Higuchi K : Distribution of transmissible
amyloid proteins in the liver with apolipoprotein A-II
amyloidosis. Shinshu Medical Journal 64: 183-194, 2016.
20160389
Yang M, Liu F, Higuchi K, Sawashita J, Fu
X, Zhang L, Zhang L, Fu L, Tong Z, Higuchi K : Serum
amyloid A expressed in the breast cancer tissue is associatedwith poor prognosis. Oncotarget 7: 35843-35852, 2016.
20160390
Sawashita J, Zhang B, Kametani F, Naiki H,
Higuchi K : The C-terminal sequence of mouse type F
apolipoprotein A-II may inhibit AApoAII amyloid fibril
formation by blocking the seeding activity of amyloid
fibrils. In: Kluve-Beckerman B, Liepnieks J.J, Benson M.D.
eds. The XIVth International Symposium on Amyloidosis.
“Amyloid: Insoluble, but Solvable". Indianapolis, USA:International Society of Amyloidosis; 2016. p.196-199.
20160391
Luo H, Sawashita J, Tian G, Liu Y, Li L, Ding
Z, Xu Z, Yang M, Miyahara H, Mori M, Qian J, Wang Y,
Higuchi K : Deposition of mouse senile AApoAII amyloid
fibrils induced unfolded protein responses in the liver,kidney and heart. In: Kluve-Beckerman B, Liepnieks J.J,
Benson M.D. eds. The XIVth International Symposiumon Amyloidosis. “Amyloid: Insoluble, but Solvable".
Indianapolis, USA: International Society of Amyloidosis;
2016. p.200-203.

Neuroplasticity
20160392
Tanahashi H, Tian QB, Hara Y, Sakagami H,
Endo S, Suzuki T : Polyhydramnios in Lrp4 knockout micewith bilateral kidney agenesis: Defects in the pathways ofamniotic fluid clearance. Sci Rep 6: 20241, 2016.

Molecular Pathology
20160393
Ueno N, Shimizu A, Kanai M, Iwaya Y,
Nakayama J, Seo MK : Enhanced expression of fibroblast
growth factor receptor 3 IIIc promotes human esophageal
carcinoma cell proliferation. J Histochem Cytochem 64:
7-17, 2016.
20160394
Momose T, Yoshimura Y, Harumiya S, Isobe K,
Kito M, Fukushima M, Kato H, Nakayama J : Chondroitin
sulfate synthase 1 expression is associated with malignant
potential of soft tissue sarcomas with myxoid substance.
Hum Pathol 50: 15-23, 2016.
20160395
Onozato T, Nakahara A, Suzuki-Kouyama E,
Hineno A, Yasude T, Nakamura T, Yahikozawa H, Watanabe
M, Kayanuma K, Makishita H, Ohara S, Hashimoto T,
Higuchi K, Sakai T, Asano K, Hashimoto T, Kanno H,

27

Nakayama J, Oyanagi K : Axonal TDP-43 aggregates insporadic amyotrophic lateral sclerosis. Neuropathol Appl
Neurobiol 42: 561-572, 2016.
20160396
Kato M, Marumo M, Nakayama J, Matsumoto
M, Yabe-Nishimura C, Kamata T : The ROS-generatingoxidase Nox1 is required for epithelial restitution following
colitis. Exp Anim 65: 197-205, 2016.
20160397
Okada N, Fujii C, Matsumura T, Kitazawa M,
Okuyama R, Taniguchi S, Hida S : Novel role of ASC asa regulator of metastatic phenotype. Cancer Med 5: 24872500, 2016.
20160398
Oyanagi K, Yamada M, Hineno A, Yahikozawa
H, Ushiyama M, Miki J, Kanno H, Nakayama J, Makishita
H, Inoue K, Ohara S, Hayashida K, Kayanuma K,
Yamamoto K, Yasude T, Hashimoto T, Yoshida K, Ikeda SI :Shinshu Brain Resource Net. Neuropathology 36: 600-601,
2016.

20160404
Harada M, Kamijo Y, Nakajima T, Hashimoto
K, Yamada Y, Shimojo H, Gonzalez FJ, Aoyama T :Peroxisome proliferator-activated receptor α-dependent
renoprotection of murine kidney by irbesartan. Clin Sci(Lond) 130: 1969-1981, 2016.
20160405
Fang ZZ, Zhang D, Cao YF, Xie C, Lu D, Sun
DX, Tanaka N, Jiang C, Chen Q, Chen Y, Wang H, Gonzalez
FJ : Irinotecan (CPT-11)-induced elevation of bile acids
potentiates suppression of IL-10 expression. Toxicol Appl
Pharmacol 291: 21-27, 2016.
20160406
Fujimori N, Tanaka N, Shibata S, Sano K,
Yamazaki T, Sekiguchi T, Kitabatake H, Ichikawa Y, Kimura
T, Komatsu M, Umemura T, Matsumoto A, Tanaka E :Controlled attenuation parameter is correlated with actual
hepatic fat content in patients with non-alcoholic fatty liverdisease with none-to-mild obesity and liver fibrosis. Hepatol
Res 46: 1019-1027, 2016.

20160399
Tanaka Y, Nakayama J : Upregulated epidermal
growth factor receptor expression following near-infraredirradiation simulating solar radiation in a three-dimensional
reconstructed human corneal epithelial tissue culture model.
Clin Interv Aging 11: 1027-1033, 2016.

20160407
Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka
N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K,
Gonzalez FJ, Aoyama T : Age-dependent PPARα activationinduces hepatic sulfatide accumulation in transgenic micecarrying the hepatitis C virus core gene. Glycoconj J 33:
927-936, 2016.

20160400
Hoshino H, Ohta M, Ito M, Uchimura K, Sakai
Y, Uehara T, Low S, Fukushima M, Kobayashi M : Apicalmembrane expression of distinct sulfated glycans represents
a novel marker of cholangiolocellular carcinoma. Lab Invest
96: 1246-1255, 2016.

20160408
Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka
N, Sugiyama E, Kamijo Y, Aoyama T : Activation of PPARα
by fatty acid accumulation enhances fatty acid degradationand sulfatide synthesis. Tohoku J Exp Med 240: 113-122,
2016.

20160401
Kondo Y, Kinoshita M, Yoshida T, Matoba H,
Uehara T, Ikeyama M, Nakayama J, Yoshida K, Ikeda SI :Unexpected occurrence of fetal hemophagocytic syndrome
in a patient with hereditary diffuse leukoencephalopathy
with spheroids. Case Rep Clin Med 5: 77-84, 2016.

20160409
Nakamura K, Koyama M, Ishida R, Kitahara T,
Nakajima T, Aoyama T : Characterization of bioactive agentsin five types of marketed sprouts and comparison of theirantihypertensive, antihyperlipidemic, and antidiabetic effects
in fructose-loaded SHRs. J Food Sci Technol 53: 581-590,
2016.

20160402
Nakayama J : Function of unique O-glycan
structures in protecting gastric mucosa against Helicobacter
pylori infection and gastric cancer development. In:
Furukawa K and Fukuda M eds. Glycosignals in Cancer:
Mechanisms of Malignant Phenotypes. Tokyo: Springer
Japan; 2016. p.111-124.

Metabolic Regulation
20160403
Harada Y, Tanaka N, Ichikawa M, Kamijo Y,
Sugiyama E, Gonzalez FJ, Aoyama T : PPARα-dependentcholesterol/testosterone disruption in Leydig cells mediates
2,4-dichlorophenoxyacetic acid-induced testicular toxicity inmice. Arch Toxicol 90: 3061-3071, 2016.

20160410
Horiuchi A, Makino T, Kajiyama M, Tanaka
N, Sano K, Graham DY : Comparison between endoscopic
mucosal resection and hot snare resection of large
nonpedunculated colorectal polyps: a randomized trial.
Endoscopy 48: 646-651, 2016.
20160411
Sakamoto T, Horiuchi A, Makino T, Kajiyama
M, Tanaka N, Hyodo M : Determination of the cut-off
score of an endoscopic scoring method to predict whether
elderly patients with dysphagia can eat pureed diets. World J
Gastrointest Endosc 8: 288-294, 2016.
20160412

Horiuchi A, Tamaki M, Kajiyama M, Tanaka

28

N : Value of an oral elemental diet during induction therapy
of ulcerative colitis with infliximab: a pilot study. J Nutrit
Health Food Sci 4: 1-5, 2016.

Cardiovascular Research
20160413
Sakurai T, Kamiyoshi A, Kawate H, Mori C,
Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T : A
non-inheritable maternal Cas9-based multiple-gene editing
system in mice. Sci Rep 6: 20011, 2016.
20160414
Ayuzawa N, Nagase M, Ueda K, Nishimoto
M, Kawarazaki W, Marumo T, Aiba A, Sakurai T, Shindo
T, Fujita T : Rac1-mediated activation of mineralocorticoid
receptor in pressure overload-induced cardiac injury.
Hypertension 67: 99-106, 2016.
20160415
Tokudome T, Kishimoto I, Shindo T, Kawakami
H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno
M, Nakao K, Kangawa K : Importance of endogenous atrial
and brain natriuretic peptides in murine embryonic vascularand organ development. Endocrinology 157: 358-367, 2016.
20160416
Uemura T, Mori T, Kurihara T, Kawase S,
Koike R, Satoga M, Cao X, Li X, Yanagawa T, Sakurai
T, Shindo T, Tabuchi K : Fluorescent protein tagging ofendogenous protein in brain neurons using CRISPR/Cas9mediated knock-in and in utero electroporation techniques.
Sci Rep 6: 35861, 2016.
20160417
Iesato Y, Yuda K, Chong K.T.Y, Tan X, Murata
T, Shindo T, Yanagi Y : Adrenomedullin: A potential
therapeutic target for retinochoroidal disease. Prog Retin Eye
Res 52: 112-129, 2016.
20160418
Yo s h i z a w a T Ta k i z a w a S , S h i m a d a S ,Tokudome T, Shindo T, Matsumoto K : Effects ofadrenomedullin on doxorubicin-induced cardiac damage inmice. Biol Pharm Bull 39: 737-746, 2016.
20160419
Tanaka M, Koyama T, Sakurai T, Kamiyoshi
A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A,
Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K,
Taniguchi S, Shindo T : The endothelial adrenomedullinRAMP2 system regulates vascular integrity and suppresses
tumour metastasis. Cardiovasc Res 111: 398-409, 2016.

Sports Medical Sciences
20160420
Masuki S, Morita A, Kamijo Y, Ikegawa S,
Kataoka Y, Ogawa Y, Sumiyoshi E, Takahashi K, Tanaka
T, Nakajima M, Nose H : Impact of 5-aminolevulinic acidwith iron supplementation on exercise efficiency and home-

based walking training achievement in older women. J Appl
Physiol (1985) 120: 87-96, 2016.
20160421
Handa S, Masuki S, Ohshio T, Kamijo Y,
Takamata A, Nose H : Target intensity and interval walking
training in water to enhance physical fitness in middle-aged
and older women: a randomised controlled study. Eur J Appl
Physiol 116: 203-215, 2016.
20160422
Kataoka Y, Kamijo Y, Ogawa Y, Sumiyoshi E,
Nakae M, Ikegawa S, Manabe K, Morikawa M, Nagata M,
Takasugi S, Masuki S, Nose H : Effects of hypervolemia byprotein and glucose supplementation during aerobic training
on thermal and arterial pressure regulations in hypertensive
older men. J Appl Physiol (1985) 121: 1021-1031, 2016.

Blood Transfusion Center
20160423
Ogawa A, Yanagisawa R : Deformation oferythroblasts in transient erythroblastopenia of childhoodcaused by HHV-6. Blood 127: 2776-2776, 2016.
20160424
Yanagisawa R, Takeuchi K, Kurata T, Sakashita
K, Shimodaira S, Ishii E : Transfusion-related acute lunginjury in an infant. Pediatr Int 58: 543-544, 2016.
20160425
Yanagisawa R, Shimodaira S, Sakashita K,
Hidaka Y, Kojima S, Nishijima F, Hidaka E, Shiohara M,
Nakamura T : Factors related to allergic transfusion reactions
and febrile non-haemolytic transfusion reactions in children.
Vox Sang 110: 376-384, 2016.
20160426
Yanagisawa R, Nakazawa Y, Sakashita K,
Saito S, Tanaka M, Shiohara M, Shimodaira S, Koike K :Intrathecal donor lymphocyte infusion for isolated leukemia
relapse in the central nervous system following allogeneic
stem cell transplantation: a case report and literature review.
Int J Hematol 103: 107-111, 2016.

Rehabilitation Center
20160427
Ido Y, Uchiyama S, Nakamura K, Itsubo T,
Hayashi M, Hata Y, Imaeda T, Kato H : Postoperative
improvement in DASH score, clinical findings, and nerve
conduction velocity in patients with cubital tunnel syndrome.
Sci Rep 6: 27497, 2016.
20160428
Yamamoto S, Hotta K, Ota E, Matsunaga A,
Mori R : Exercise-based cardiac rehabilitation for people
with ventricular assist devices (Protocol). Cochrane
Database Syst Rev 2016: CD012222, 2016.
20160429

Yamamoto S, Hotta K, Ota E, Matsunaga A,

29Mori R : Effects of resistance training on muscle strength,
exercise capacity, and mobility in middle-aged and elderly
patients with coronary artery disease: a meta-analysis. J
Cardiol 68: 125-134, 2016.
20160430
Shimizu R, Hotta K, Yamamoto S, Matsumoto
T, Kamiya K, Kato M Hamazaki N, Kamekawa D,
Akiyama A, Kameda Y, Tanaka S, Masuda T : Lowintensity resistance training with blood flow restriction
inproves vascular endothelial function and peripheral blood
circulation in healthy elderly people. Eur J Appl Physiol 116:749-757, 2016.
20160431
Yamamoto S, Yamaga T, Sakai Y, Ishida T,
Nakasone S, Ohira M, Ota E, Mori R : Association between
physical performance and cardiovascular events in patientswith coronary artery disease: protocol for a meta-analysis.
Syst Rev 5: 32, 2016.
20160432
Abe Y, Matsunaga A, Matsuzawa R, Kutsuna
T, Yamamoto S, Yoneki K, Harada M, Ishikawa R,
Watanabe T, Yoshida A : Determinants of Slow Walking
Speed in Ambulatory Patients Undergoing Maintenance
Hemodialysis. PLoS One 11: e0151037, 2016.

Medical Informatics

20160437
Mochida K, Amano M, Miyake N, Matsumoto
N, Hatamochi A, Kosho T : Dermatan 4-O-sulfotransferase
1-deficient Ehlers-Danlos syndrome complicated by a large
subcutaneous hematoma on the back. J Dermatol 43(7): 832833, 2016.
20160438
Kono M, Hasegawa-Murakami Y, Sugiura
K, Ono M, Toriyama K, Miyake N, Hatamochi A,
Kamei Y, Kosho T, Akiyama M : A 45-year-old Woman
with Ehlers-Danlos Syndrome Caused by Dermatan
4-O-sulfotransferase-1 Deficiency: Implications for Early
Ageing. Acta Derm Venereol 96(6): 830-831, 2016.
20160439
Kosho T, Carey JC : Does medical intervention
affect outcome in infants with trisomy 18 or trisomy 13?.
Am J Med Genet A 170(4): 847-849, 2016.
20160440
Uehara DT, Hayashi S, Okamoto N, Mizuno
S, Chinen Y, Kosaki R, Kosho T, Kurosawa K, Matsumoto
H, Mitsubuchi H, Numabe H, Saitoh S, Makita Y, Hata A,
Imoto I, Inazawa J : SNP array screening of cryptic genomic
imbalances in 450 Japanese subjects with intellectual
disability and multiple congenital anomalies previously
negative for large rearrangements. J Hum Genet 61(4): 335343, 2016.

20160433
Kiniwa Y, Matoba H, Hamano H, Senoo Y,
Okuyama R : Cutaneous plasmacytosis associated with
autoimmune hemolytic anemia. J Dermatol 43: 343-345,
2016.

20160441
Nishi E, Masuda K, Arakawa M, Kawame
H, Kosho T, Kitahara M, Kubota N, Hidaka E, Katoh
Y, Shirahige K, Izumi K : Exome sequencing-based
identification of mutations in non-syndromic genes amongindividuals with apparently syndromic features. Am J Med
Genet A 170(11): 2889-2894, 2016.

20160434
Oguchi T, Ota M, Ito T, Hamano H, Arakura N,
Katsuyama Y, Meguro A, Kawa S : Correction: Investigationof Susceptibility Genes Triggering Lachrymal/Salivary
Gland Lesion Complications in Japanese Patients with Type
1 Autoimmune Pancreatitis. PLOS ONE 11: e0146738,
2016.

20160442
Carey JC, Kosho T : Perspectives on the care
and advances in the management of children with trisomy 13
and 18. Am J Med Genet C Semin Med Genet 172(3): 249250, 2016.

20160435
Kanai K, Maruyama M, Kameko F, Kawasaki
K, Asano J, Oguchi T, Watanabe T, Ito T, Muraki T, Hamano
H, Matsumoto A, Arakura N, Kawa S : Autoimmune
Pancreatitis Can Transform Into Chronic Features Similar
to Advanced Chronic Pancreatitis With Functional
Insufficiency Following Severe Calcification. Pancreas 45:
1189-1195, 2016.

Center for Medical Genetics
20160436
Kosho T : CHST14/D4ST1 deficiency: Newform of Ehlers-Danlos syndrome. Pediatr Int 58(2): 88-99,
2016.

20160443
Akazawa Y, Motoki N, Tada A, Yamazaki S,
Hachiya A, Matsuzaki S, Kamiya M, Nakamura T, Kosho
T, Inaba Y : Decreased Aortic Elasticity in Children With
Marfan Syndrome or Loeys-Dietz Syndrome. Circ J 80(11):2369-2375, 2016.
20160444
Takahashi J, Hirabayashi H, Hashidate H,
Ogihara N, Mukaiyama K, Komatsu M, Inaba Y, Kosho T,
Kato H : Challenges of Transarticular Screw Fixation in
Young Children: Report of Surgical Treatment of a 5-YearOld Patient's Unstable Os-Odontoideum. Asian Spine J
10(5): 950-954, 2016.

30

2016.

Cochlear Implant Center
20160445
Miyagawa M, Nishio S, Usami S : A
Comprehensive Study on the Etiology of Patients Receiving
Cochlear Implantation With Special Emphasis on Genetic
Epidemiology. Otol Neurotol 37(2): e126-e134, 2016.

Advence Center for Cellular Therapy
20160446
Koido S, Okamoto M, Shimodaira S, Sugiyama
H : Wilms' tumor 1 (WT1)-targeted cancer vaccines
to extend survival for patients with pancreatic cancer.
Immunotherapy 8: 1309-1320, 2016.
20160447
Takahashi H, Shimodaira S, Ogasawara M,
Ota S, Kobayashi M, Abe H, Morita Y, Nagai K, Tsujitani
S, Okamoto M, Suzuki Y, Nakanishi Y, Yonemitsu Y;
DC Vaccine Study Group at the Japanese Society of
Immunotherapy and Cell Therapy : Lung adenocarcinoma
may be a more susceptive subtype to a dendritic cellbased cancer vaccine than other subtypes of non-small celllung cancers: a multicenter retrospective analysis. Cancer
Immunol Immunother 65: 1099-1111, 2016.
20160448
Higuchi Y, Kawakubo M, Yuzawa M, Sano
K, Shimodaira S : WT1 peptide vaccine is unaffected byairport screening X-irradiation. Austin Journal of Vaccines &Immunotherapeutics 3: 1010, 2016.
20160449
Kajihara M, Takakura K, Kanai T, Ito Z,
Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T, Koido
S : Advances in inducing adaptive immunity using cell-based
cancer vaccines: clinical applications in pancreatic cancer.
World J Gastroenterol 22: 4446-4458, 2016.
20160450
Kajihara M, Takakura K, Kanai T, Ito Z,
Shimodaira S, Okamoto M, Ohkusa T, Koido S : Dendritic
cell–based cancer immunotherapy for colorectal cancer.
World J Gastroenterol 22: 4275-4286, 2016.
20160451
Shimodaira S, Hirabayashi K, Koya T, Higuchi
Y, Yanagisawa R, Okamoto M, Koido S : An update on
dendritic cell-based cancer immunotherapy. Immunome Res
12: 106, 2016.
20160452
Shimodaira S, Koya T, Higuchi Y, Okamoto
M, Koido S : Quality Verification of Dendritic Cell-Based
Cancer Vaccine. Pharm Anal Acta 7: 465, 2016.
20160453
Shimodaira S, Higuchi Y, Yanagisawa R,
Okamoto M, Koido S : Efficacy of dendritic cell-based
cancer immunotherapy. Biochem Anal Biochem 5: 240,

20160454
Shimodaira S, Hirabayashi K, Yanagisawa
R, Higuchi Y, Sano K, Koizumi T : Dendritic Cell-Based
Cancer Immunotherapy Targeting Wilms’ Tumor 1 forPediatric Cancer. In: van den Heuvel-Eibrink MM. Wilms
Tumor. Brisbane (AU): Codon Publications; 2016. p.113130.

Department of Pharmacy
20160455
Ya n a g i s a w a R , N o g u c h i M , F u j i t a K ,Sakashita K, Sano K, Ogiso Y, Katsuyama Y, Kondo Y,
Komori K, Fujihara I, Kitamura R, Hiroma T, Nakamura
T : Preoperative treatment with pazopanib in a case of
chemotherapy-resistant infantile fibrosarcoma. Pediatr Blood
Cancer 63: 348-351, 2016.
20160456
Fuseya S, Yamamoto K, Minemura H, Yamaori
S, Kawamata T, Kawamata M : Systemic QX-314 reducesbone cancer pain through selective inhibition of transient
receptor potential vanilloid subfamily 1-expressing primaryafferents in mice. Anesthesiology 125: 204-218, 2016.
20160457
Nonomiya Y, Noguchi K, Tanaka N, Kasagaki
T, Katayama K, Sugimoto Y : Effect of AKT3 expression on
MYC- and caspase-8-dependent apoptosis caused by pololike kinase inhibitors in HCT 116 cells. Cancer Sci 107:
1877-1887, 2016.

Clinical Resident Training Center
20160458
Ando Y, Sekijima Y, Obayashi K, Yamashita T,
Ueda M, Misumi Y, Morita H, Machii K, Ohta M, Takata
A, Ikeda S : Effects of tafamidis treatment on transthyretin(TTR) stabilization, efﬁcacy, and safety in Japanese patientswith familial amyloid polyneuropathy (TTR-FAP) with
Val30Met and non-Varl30Met: A phase III, open-label study.
J Neurol Sci 362: 266-271, 2016.
20160459
Robles L, Vaziri ND, Li S, Masuda Y, Takasu
C, Takasu M, Vo K, Farzaneh SH, Stamos MJ, Ichii H: Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA)
Ameliorates Acute Pancreatitis. Pancreas 45: 720-729, 2016.

Laboratory of Animal Research
20160460
Yo s h i z a w a T, Ta k i z a w a S , S h i m a d a S ,Tokudome T, Shindo T, Matsumoto K : Effects ofAdrenomedullin on Doxorubicin-induced Cardiac Damage
in Mice. Biol Pharm Bull 39(5): 737-746, 2016.

31

Radioisotope Experiments
20160461
Kurihara O, Kanai K, Hirota M, Kim E, Tani
K, Takada C, Momose T : Application of an Imaging
Plate for Evaluating the UNCERTAINTY in Direct Organ
Measurements due to Variation in Detector Location. Radiat
Prot Dosimetry 170: 252-255, 2016.

33

補

遺
No．44
2015

35

Surgery 1
20150501
Masuda Y, Vaziri ND, Takasu C, Li S, Robles
L, Pham C, Le A, Vo K, Farzaneh SH, Stamos MJ, Ichii H: Salutary effect of pre-treatment with an Nrf2 inducer on
ischemia reperfusion injury in the rat liver. Gastroenterol
Hepatol (Que) 1: 1-7, 2014.

Laboratory Medicine
20150502
Hayashi T, Horiuchi A, Sano K, Yaegashi
N, Konishi I : Uterine Leiomyosarcoma Tumorigenesis
in Lmp2-deficient Mice: Involvement of Impaired Antioncogenic Factor IRF1. Anticancer Res 35(9): 4665-4679,
2015.
20150503
Yamamoto H, Yasuo M, Ichiyama T, Ushiki A,
Hanaoka M, Hamano H, Uehara T, Kawakami S, Matsui S,
Kubo K : Cytokine profiles in the BAL fluid of IgG4-related
respiratory disease compared with sarcoidosis. ERJ OpenRes 1(2): 00009-2015, 2015.

信大
州学
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医部
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編要
集項
要（
項抜粋）
信州

あ

（平成28年12月29日改正）

１．収録対象 ２．収録対象
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学術集会記録（全国的又は世界的規模の集会記録で、原著論文と同様の内容をもち、ち、別刷が発行されているもの）
別刷が発行されているもの）
２）著書
２）著書
単行書、分担執筆。
単行書、分担執筆。
３）その他
治
 療指針、トピックス、事典等、専門的知見にもとづき執筆された、論文形式の
ただし、以下のものは除外する。
記事（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表に関するもの及び１頁ものの速報は抄録とみなす）
ただし、以下のものは除外する。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（イ）学会発表の抄録（邦文、欧文を問わない。論文型式をとっていても学会発表（ハ）業務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）
に関するもの及び１頁ものの速報は抄録とみなす）（ニ）座談会記事。
（ロ）セミナー、シンポジウム、その他の講演のテキストないし記録。
（ホ）学会記。
（ハ）業and
務報告書（文部科学省、厚生労働省、その他助成機関への研究報告書）（ヘ）質疑応答（ＱＡ）
、治療指針、問題集の解説、トピックス、話題、グラビア、
（ニ）
座
談会記事。
事典等に類するもの。
（ホ）学会記。
（ト）新聞記事、教育に関する記事、人物紹介、書評、随筆など学術性が認められ（ヘ）
ないもの。 論文形式をとらない質疑応答（Q and A）、問題集の解説、話題、グラビア等に類するもの。
（チ）著者表示が団体名で個人の著者性が認められないもの。
（ト）新聞・週刊誌記事、教育に関する記事、人物紹介、書評、随筆など学術性が（リ）学術雑誌とは認められないものに発表したもの。
認められないもの。
（ヌ）訳本及び訳論文。
（チ）著者表示が団体名で個人の著者性が認められないもの。
４．収録期間
毎年１月～12月とがき

信州大学医学部医学科
・大学院医学系研究科・医学部附属病院業績録第45号をお届けします。
信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録第38 号をお届けします。
本業績録は過去１年間、各教室や部門などでなされた４つの活動（研究活動、教育活動、診本業績録は過去１年間、各講座や部門等でなされた４つの活動（研究、教育、診療、社会貢献）
療活動、社会貢献）のうち、研究活動の成果として公表された論文を中心にまとめたものです。
のうち、研究活動の成果として公表された論文を中心にまとめたものです。自己点検、自己評
自己点検、自己評価、学内・学外への報告において、本業績録の役割は重要と思われます。この１年の研究活動を振り返り、今後の方向性を考える契機にしていただければ幸いです。
価、学内外への報告において、本業績録の果たす役割は重要と思われます。このような観点から、
この１年間の研究活動を振り返り、今後の方向性等を考える契機にしていただけたら幸いに存
医学論文数の動向をみると、トップの米国以下、英独さらには豪印中国などの伸びが目立つじます。
なか、わが国は2000年頃から停滞ないし低い伸びにとどまっており、基礎および臨床医学とも、世界における存在感の低下が続いています。これには大学予算の減額や、新臨床研修制度下での若手医師の大学離れによる研究者の減少など、様々な要因が指摘されており、信州大学もこ
今年度の英文論文総数は昨年度より微減し、90 年度以降で最も少ない 386 という結果となり
れらの影響を無視することはできません。しかし、そのなかで2016年度も461本の英文業績がました。しかしながら、単なる総数のみの評価が必ずしも適切であるとは言えず、今年度の業発表されました。この１つ１つが多くの先生方のご努力の賜物でありますが、今後も、医学の発展に大きく寄与するような瞠目すべき成果が、ここ信州の地から次々と発信されていくこと
績の中には極めて質の高い研究成果も少なくありません。今日、卒業生の大学離れや医学科入を期待したいと思います。
学定員数増加等により、診療や教育活動等の業務負荷は増加の一途にあります。このような現状ではありますが、研究活動は大学が大学であるための大きな責務であり、外部評価基準の重最後に、本業績録の編集にあたりご尽力頂きました先生方、図書館職員の方々に厚く御礼申
要項目であることは言うまでもありません。今後、各講座・部門等でのさらなる研究の発展をし上げます。



祈念致します。

鷲塚伸介

出 最後に、本業績録の編集にあたりご尽力頂きました先生方、図書館職員の方々に厚く御礼申
版 委 員 長：鷲塚伸介
出し上げます。
版 委 員：中沢洋三、伊東清志、森政之
医学部図書館主査：岩井雅史
浅村英樹
出 版 委 員 長：浅村英樹
出版

委員：奥山隆平、石田文宏、川股知之

医学部図書館主査：石坂憲司

信州大学医学部医学科・大学院医学系研究科
・医学部附属病院業績録 第
第 45
38 号
号
平成
2830
日印刷
平成 23
29 年１月年 11 月
日印刷
平成
2830
日発行
平成 23
29 年１月年 11 月日発行
編集兼 信 州 大 学 医 学 部
発行者 松本市旭 3 丁目 1 の 1
印刷所

藤原印刷株式会社

松本市新橋 7 の 21 番地

ISSN 1881ー4980

信 州 大 学 医 学 部 医 学 科・大 学 院 医 学 系 研 究 科・医 学 部 附 属 病 院 業 績 録

SCIENTIFIC ACHIEVEMENTS OF SHINSHU UNIVERSITY SCHOOL OF
MEDICINE, SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE,
AND SHINSHU UNIVERSITY HOSPITAL
信州大学医学部医学科・大学院医学系研究科・医学部附属病院業績録

No.45 (2016)

第四五号（二〇一六 ）二〇一七

2017