CAS Registry Number Information Requirements
Please provide as much of the following information as possible for your substance type (including a unique substanceidentifier) along with any additional information (including CAS Registry Numbers for starting materials) that may assist
us in uniquely identifying your substances. All substance information should be submitted with a completed order form
to answers@cas.org. Orders with complete substance identity information can be processed more efficiently, resulting inlower processing costs.
Well Defined Chemical Compounds•••

Chemical structure diagram (required)
Systematic chemical name or common names
Molecular formula

Polymeric Substances
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List of monomers/reactants (required)
Representative structure diagram (required)
Reaction scheme
Role of reactants (e.g., polymer backbone, initiator, terminator)
Structural description of the type of polymer (e.g., graft, block, random)Complex Reaction Products•••

List of reactants (required)
Representative structure or typical composition of the product (required)
Reaction scheme and nature of the reaction

Plant and Animal Products•••

Genus/Genus Species of the source (required)
Method of extraction/chemical processing
Typical composition of the productProducts from Industrial Processes••••••Precursors and precursor source (e.g., petroleum, coal, waste plastics) (required)Process description (e.g., catalytic cracking, dewaxed) (required)
Schematic diagram depicting the industrial process and the point where the substance is isolated
Carbon (alkyl) range (e.g., C4 through C12)
Principal chemical composition (e.g., alkanes, alkenes, aromatics)
Physical properties (e.g., boiling range, viscosity, solid, slag)

Biologics (Biopharmaceuticals)
For protein, DNA, or RNA substances, please provide the following when applicable:••

Sequence data (Word document is preferable).
o Single-letter code for each amino acid or nucleotide▪ 10 amino acids per group, spaces between groups, 5 groups per line.
▪ Positions numbered for last amino acid in each line.
o For nucleotide sequences:▪ Sequence with spaces between codons and translation (including stop codon) with numbering
per line.
Disulfide Bridge positions•
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Indicate if the substance is naturally occurring or synthetic.
Indicate if the substance is the wildtype full-length molecule or a fragment.
Biological source (genus species).
Specific function or activity of the substance
Modification information (e.g., mutations, glycosylation, etc.)
If the product is a DNA/RNA construct or fusion protein, provide details on each component used in theconstruction of the final product including source.
Trivial Name or Code Designation

For antibodies, please provide the above information and the following (when applicable):
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Antibody format (e.g., complete antibody, Fab, scFv, etc.)
Expression system (cell type, strain, etc.)
Immunoglobulin class and subclass for heavy and light chains.
Biological source for humanized or chimeric antibody.
Antigen and its genus species
If conjugated to another molecule, provide attachment position of the molecules(s) and the mean number ofmolecules attached to an antibody.
Illustration showing domain arrangement and linkage of domains.