シンポジウム

第 1 日目11 月 25 日（火）第1日目11月25日（火）1S1

9:00-11:30【E】

Organizers：Eisuke Nishida (Graduate School of Biostudies, Kyoto University)
Eiji Hara (Div. of Cancer Biol., Cancer Institute, JFCR)

1S1-1 Mechanisms of life-span regulation by environmental stresses in C. elegans【9:00】

Masaharu Uno, Eisuke Nishida（Graduate School of Biostudies, Kyoto University）

1S1-2 The roles of cellular senescence in aging and cancer【9:30】

Akiko Takahashi, Eiji Hara（Div. of Cancer Biol., Cancer Institute, JFCR）

1S1-3 Hypoxia response and age-related macular degeneration【10:00】Toshihide Kurihara（Dept. of Ophthalmol., Med. Sch., Keio Univ.）

1S1-4 Progeroid syndrome as a model of aging-related metabolic disorders【10:30】

Koutaro Yokote1, Takahiko Shimizu2, Akira Shimamoto3, Minoru Takemoto1（1Dept. of Med., Grad. Sch. of Med.
Chiba Univ., 2Dept. of Adv. Aging Med., Grad. Sch. of Med. Chiba Univ., 3Dept. of Cell. Mol. Biol., Grad. Sch. of
Biomed. Health Sci., Hiroshima Univ）

1S1-5 Longevity mechanisms in the naked mole rat and other long-lived rodent species【11:00】

Vera Gorbunova, Andrei Seluanov（University of Rochester）

1S2

第2会場（3階 301）
Gut Microbiota on the Host Physiology and Pathology

9:00-11:30【E】

Organizers：Hiroshi Ohno (RIKEN IMS)
Naoko Ohtani (Tokyo University of Science)

1S2-1 Th17 induction by epithelial-adhering intestinal microbes【9:00】

Kenya Honda1,3,6, Koji Atarashi1,3,5, Takeshi Tanue1, Minoru Ando2, Nobuhiko Kamada4, Yuji Nagano1, Akemi
Imaoka2, Seiko Narushima1, Gabriel Nunez4, Yoshinori Umesaki2（1RIKEN IMS, 2Yakult Central Institute forMicrobiological Research, 3Keio University, Sch. of Med., 4The University of Michigan Medical School, 5JST PRESTO,
6
JST, CREST）

1S2-2 Regulation of gut microbiota by Foxp3 and IgA【9:30】

Shimpei Kawamoto, Mikako Maruya, Sidonia Fagarasan（Lab. for Mucosal Immunity, IMS, RIKEN）

1S2-3 The host and its microbiome in health and disease【10:00】Eran Elinav（Dept. of Immun, Weizmann Institute of Science）

1S2-4 Gut microbiota-derived metabolites shape host physiological homeostasis【10:30】Shinji Fukuda1,2（1Inst. Adv. Biosci., Keio Univ., 2RIKEN IMS）

1S2-5 The role of gut microbiota in obesity-associated hepatic carcinogenesis【11:00】

Naoko Ohtani1,2,3, Shin Yoshimoto2,5, Tze Mun Loo1, Eiji Hara2,4（1Dept. Applied Biol. Sci., Faculty Sci.Technol.,Tokyo
Univ. Sci., 2Div. Cancer Biol., Cancer Inst. JFCR, 3Japan Sci. Technol. Agency (JST),PRESTO, 4Japan Sci. Technol.
Agency (JST), CREST, 5LSI Medience Corp.）

The 37th Annual Meeting of the Molecular Biology Society of Japan

55

第１日目

第1会場（1階 メインホール）
Molecular Biology of Aging and Age-Related Disorders

シンポジウムシンポジウムシンポジウム

第 1 日目11 月 25 日（火）シンポジウム

1S3

9:00-11:30【E】

第3会場（3階 302）
Synthetic Study to Uncover Hierarchical Ordering of Biological Systems
Organizers：Daisuke Kiga (Tokyo Tech, Dept Comp Intel and Sys Sci/ WPI-ELSI)
Kaoru Sugimura (WPI-iCeMS, Kyoto University)

第１日目

1S3-1 【9:00】
Synthetic approach across layers of life: Cell population diversification programmed by artificial genetic
circuitDaisuke Kiga（Tokyo Tech, Dept Comp Intel and Sys Sci/ WPI-ELSI）

1S3-2 【9:15】

Designing protein molecules from scratch

Nobuyasu Koga1,2（1IMS・CIMoS, 2JST・PRESTO）

1S3-3 【9:40】

Single cell analysis through development of proteins for imaging and manipulation
Takeharu Nagai（ISIR, Osaka Univ.）

1S3-4 【10:05】Modular protein domains for designing cellular circuits and new protein folds
Roman Jerala（National Institute of Chemistry）

1S3-5 【10:35】

Sensitivity of chemical reaction networks: a structural approach

Atsushi Mochizuki1,2, Bernold Fiedler3（1Theor. Biol. Lab. RIKEN, 2CREST, JST, 3Inst. for Math., Free Univ. Berlin）

1S3-6 【11:00】

Human iPSC-derived organ bud based approaches towards functional organ generation

Takanori Takebe1,2（1Dept. of Reg. Med., Grad. Sch. of Med., Yokohama City Univ., 2PRESTO, JST）

Conclusion

【11:25】

Kaoru Sugimura（WPI-iCeMS, Kyoto University）

1S15

9:00-11:30【E】

第15会場（5階 501）
Shu Takeda Presents (Co-sponsored by JST CREST)
Interacting Organ Systems Governing Whole Body Homeostasis

Organizer：Shu Takeda (Dept. of Phy. Cell Biol., Grad. Sch. of Med. Den. Sci., Tokyo Med. Den. Univ.)

1S15-1 【9:00】

Control of bone remodeling by central nervous system

Shu Takeda（Dept. of Phy. Cell Biol., Grad. Sch. of Med. Den. Sci., Tokyo Med. Den. Univ.）

1S15-2 【9:24】

Microglia Surveillance of Neuron-Synapses

Junichi Nabekura1,2, Akiko Miyamoto1, Hiroaki Wake1,2（1National Institute for Physiological Sciences, 2Graduate
University of Advanced Studies）

1S15-3 
Intravital imaging revealing a dynamic cell system linking bone and immune systems in vivo

【9:48】

Masaru Ishii（Dept. of. Immunol. Cell Biol., Grad. Sch. Med. Frontier Biosci., Osaka Univ.）

1S15-4 
Pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity【10:12】

Kenji Kabashima（Dept. of Dermatol., Kyoto Univ. Grad. Sch. Med.）

1S15-5 
Neuronal Information Highways for Metabolic Regulation at the Whole Body Level【10:36】

Hideki Katagiri（Dept. of Metab. Diabet., Grad. Sch. of Med., Tohoku Univ.）

56

第 37 回日本分子生物学会年会

シンポジウム

第 1 日目11 月 25 日（火）【11:00】
Glut1-dependent glucose uptake in osteoblasts is necessary for bone formation before and after birth andwhole-body glucose homeostasis
Gerard Karsenty（Columbia University Medical Center）

第16会場（5階 502）
Takehiko Kobayashi Presents
Regeneration of Genome

9:00-11:30【E】

Organizer：Takehiko Kobayashi (Natl. Inst. of Genetics / Sokendai)

Introduction

【9:00】

1S16-1 【9:05】

Takehiko Kobayashi（Natl. Inst. of Genetics / Sokendai）

Instability of repetitive sequence and cellular senescence

Takehiko Kobayashi1,2, Kimiko Saka1（1Natl. Inst. of Genetics, 2Sokendai）

1S16-2 【9:33】
Cell-autonomous correction of ring chromosomes by compensatory uniparental disomy in human induced
pluripotent stem cells

Yohei Hayashi1, Shinya Yamanaka1,2（1Gladstone Institute of Cardiovascular Disease, 2Center for iPS Cell Researchand Application, Kyoto University）

1S16-3 【10:02】Oxidative DNA damage and its repair system: implications for de novo germline mutations
Mizuki Ohno（Dept. of Med. Biophys. & Radiation Biol., Faculty of Med. Sci., Kyushu Univ.）

1S16-4 【10:31】DNA damage repair and neurodegenerative diseases

Hitoshi Okazawa（TMDU, Medical Research Institute/Center for Brain Integration Research）

1S16-5 
Suppression of somatic expansion delays motor decline in a mouse model of Huntingtons disease【11:00】Cynthia T. Mcmurray, Helen Budworth, Faye Harris, Paul T. Williams, Do-Yup Lee, Jens Pahnke, Bartosz
Szczesny, Sankar Mitra, Karina Acevedo-Torres, Sylvette Ayala-Pena（Lawrence Berkeley National Lab.）

Conclusion

【11:30】

Takehiko Kobayashi（Natl. Inst. of Genetics / Sokendai）

1S17

第17会場（5階 503）
Tamotsu Yoshimori Presents
Inside Cells, Membranes Move, Fission, and Fuse to Maintain Life

9:00-11:30【E】

Organizer：Tamotsu Yoshimori (Graduate School of Frontier Biosciences / Medicine, Osaka University)

Introduction

【9:00】

1S17-1 【9:03】

Tamotsu Yoshimori（Graduate School of Frontier Biosciences / Medicine, Osaka University）

Regulation of myosin V interaction with cargoes

Richard G Yau, Yui Jin, Sara Wong, Lois Weisman（Life Sciences Institute, Department of Cell and Developmental
Biology, University of Michigan)

1S17-2 【9:24】
Resolving the contributions of the actin machinery to endocytic membrane bending and vesicle formation

Wanda Kukulski1,2, Andrea Picco1, Tanja Specht1, Hetty Manenschijn1, John A. G. Briggs1,2, Marko Kaksonen1,2（1Cell
Biology and Biophysics Unit, EMBL Heidelberg, 2Structural and Computational Biology Unit, EMBL Heidelberg）

The 37th Annual Meeting of the Molecular Biology Society of Japan

57

第１日目

1S16

シンポジウム

1S15-6 シンポジウム

第 1 日目11 月 25 日（火）シンポジウム

1S17-3 
Dynamic Regulation of Autophagy and Endocytosis for Cell Remodeling during Early Development in
C. elegans【9:45】

Miyuki Sato1, Ryosuke Konuma2, Kotone Tomura2, Ken Sato2（1Lab. of Mol. Memb. Biol., IMCR, Gunma Univ., 2Lab.
of Mol. Traffic, IMCR, Gunma Univ.）

第１日目

1S17-4 【10:06】

Analysis on the autophagosome formation site

Maho Hamasaki1,2, Akiko Nezu2, Tamotsu Yoshimori1,2（1Dept. of Genetics, Grad. Sch. of Med., Osaka University,2
Dept. of Intracellular Memb. Dynamics, Grad. Sch. of Frontier Biosciences）

1S17-5 
The small GTPase Arf1 modulates mitochondrial morphology and function【10:25】Karin B. Ackema1, Jürgen Hench2, Stefan Böckler3, Shyi Chyi Wang4, Ursula Sauder5, Heidi Mergentaler1, Benedikt
Westermann3, Frédéric Bard4, Stephan Frank2, Anne Spang1（1Growth and Development, Biozentrum, Universityof Basel, 2Division of Neuropathology, Institute of Pathology, University Hospital Basel, 3Cell Biology, University of
Bayreuth, 4Institute for Molecular and Cell Biology, 5Microscopy Center, Biozentrum, University of Basel）

1S17-6 【10:46】

Catching vesicles at the Golgi complex

Suzanne Pfeffer（Dept. Biochemistry, Stanford University School of Medicine）

1S17-7 
Rab6 is essential for plural apical transport pathways but not for basolateral transport pathway in
Drosophila photoreceptors【11:07】

Nozomi Iwanami, Takunori Satoh, Yuri Nakamura, Jiguan Liu, Akiko Satoh（Graduate School of Integrated Arts
and Sciences, Hiroshima University）

Conclusion

Maho Hamasaki1,2（1Dept. of Genetics, Grad. Sch. of Med., Osaka University, 2Dept. of Intracellular Memb.
Dynamics, Grad. Sch. of Frontier Biosciences）

58【11:28】

第 37 回日本分子生物学会年会

シンポジウム

第 2 日目11 月 26 日（水）第2日目11月26日（水）2S1

第1会場（1階 メインホール）
Mitinori Saitou Presents
Programming/Reprogramming Stem Cell Fate

9:00-11:30【E】

Organizer：Mitinori Saitou (Graduate School of Medicine, Kyoto University)【9:00】

2S1-1 【9:10】

Mitinori Saitou（Graduate School of Medicine, Kyoto University）

Epigenetic Control of Mammalian Germ Line and Early Embryonic Development

Antoine H.F.M. Peters（Friedrich Miescher Institute for Biomedical Research, Switzerland）

2S1-2 Epigenetic abnormalities associated with somatic cell nuclear transfer in mice

【9:45】

Atsuo Ogura1,2（1RIKEN BioResource Center, 2Grad. Sch. of Life Environ. Sci., Univ. of Tsukuba）

2S1-3 The Epigenetic Instability of the Pluripotent and Somatic Cell States【10:20】

Jacob Hanna（Weizmann Institute of Science）

2S1-4 Programming stem cells toward the kidney【10:55】

Ryuichi Nishinakamura, Atsuhiro Taguchi（Inst. Mol. Embryol. Genet., Kumamoto Univ.）

2S2

第2会場（3階 301）
Toru Takumi Presents
Molecular Biology of Brain and Mind

9:00-11:30【E】

Organizer：Toru Takumi (RIKEN・BSI)

Introduction

【9:00】

2S2-1 【9:03】

Toru Takumi（RIKEN・BSI）

Molecular approaches towards understanding the pathophysiology of mental disorders
Toru Takumi（RIKEN・BSI）

2S2-2 Supramolecular organisation of the synapse【9:15】

Seth Grant（Genes to Cognition Programme, Edinburgh University, UK）

2S2-3 Probing integrin function in brain networks【9:50】

Yukiko Goda（RIKEN Brain Science Institute）

2S2-4 Synaptic scaffolding proteins, NMDA receptor function, and autism spectrum disorders【10:20】Eunjoon Kim1,2（1Center for Synaptic Brain Dysfunctions, Inst. of Basic Sci. (IBS)., 2Dept. of Biol. Sci., Korea Adv.
Inst. of Sci. Technol (KAIST)）

2S2-5 Engineered Microbial Rhodopsins for studying Neural Circuits【10:55】Ofer Yizhar（Weizmann Institute of Science, Rehovot, Israel）

The 37th Annual Meeting of the Molecular Biology Society of Japan59

シンポジウム 第２日目

Introductionシンポジウム

第 2 日目11 月 26 日（水）2S3

9:00-11:30【E】

第3会場（3階 302）
Yuichiro Watanabe Presents
Diverse Gene Regulation Systems for Environmental Adaptation
Organizer：Yuichiro Watanabe (Graduate School of Arts and Sciences, The University of Tokyo)

Introduction

【9:00】

2S3-1 【9:05】Yuichiro Watanabe（Graduate School of Arts and Sciences, The University of Tokyo）

シンポジウム 第２日目

Epitranscriptome, the chemical modification on mRNA, in mammalian circadian rhythms
Hitoshi Okamura, Jean-Michel Fustin（Dept. System Bio., Grad. Sch. Pharm. Sci., Kyoto Univ.）

2S3-2 Linking mRNA methylation and 3' end processing to plant development【9:30】

Gordon Simpson1,2（1Division of Plant Sciences, College of Life Sciences, Dundee University, Scotland, UK, 2Cell &Molecular Sciences, The James Hutton Institute, Invergowrie, Dundee, Scotland, UK.）

2S3-3 【10:00】Genetic architecture of Arabidopsis circadian clock system
Norihito Nakamichi（WPI-ITbM, Nagoya Univ.）

2S3-4 Transcriptional and post-transcriptional regulation mediate the adaptation of the circadian clock totemperature changes【10:25】

Osnat Bartok, Naveh Evantal, Sebastian Kadener（Biological Chemistry Department, Silberman Institute of Life
Sciences, The Hebrew University of Jerusalem）

2S3-5 【10:55】

Transcriptome dynamics under fluctuating field

Atsushi J. Nagano1,2（1Cen. for Ecol. Res., Kyoto Univ., 2JST PRESTO）

Discussion

【11:20】

2S15

第15会場（5階 501）
9:00-11:30【E】
Towards Establishment of Systematical Structure-Function Analysis Technology of Membrane Proteins
Organizers：Osamu Nureki (Graduate School of Science, The University of Tokyo)
Atsuko Yamashita (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Okayama University)

2S15-1 
Improving Major Facilitator Superfamily transporters for biofuel production【9:00】

Jamie Cate1,2,3（1Dept. Molecular and Cell Biology, UC Berkeley, 2Dept. Chemistry, UC Berkeley, 3Energy Biosciences
Institute）

2S15-2 【9:35】

Molecular Mechanisms of Membrane Channel and Transporter

Osamu Nureki（Graduate School of Science, The University of Tokyo）

2S15-3 
Structural basis for the drug extrusion mechanism by a MATE multidrug transporter【9:58】

Yoshiki Tanaka1,3, Christopher J. Hipolito2, Ryuichiro Ishitani1, Hiroaki Suga2, Osamu Nureki1（1Dept. of Bioph. andBioch., Grad. Sch. of Sci., Univ. of Tokyo, 2Dept. of Chem., Grad. Sch. of Sci., Univ. of Tokyo, 3Grad. Sch. of Bio. Sci.,
NAIST）

2S15-4 In silico drug design system based on the structure of drug transporter substrates【10:21】

Hiroyuki Kusuhara, Kazuya Maeda（Grad. Sch. of Pharm. Sci., Univ. of Tokyo）

60

第 37 回日本分子生物学会年会

シンポジウム

第 2 日目11 月 26 日（水）2S15-5 【10:44】
Towards Establishment of Systematic Structure Analysis Technology for G-protein Coupled Receptors
Takeshi Murata1,2（1Dept. of Chem., Grad. Sch. of Sci., Chiba Univ., 2PRESTO, JST）

2S15-6 【11:07】Structure studies on membrane proteins using X-ray free electron laser

2S16

第16会場（5階 502）
Yoshiko Takahashi Presents
Developmental Biology: Cells-to-organs and biodiversity

9:00-11:30【E】

Organizer：Yoshiko Takahashi (Dept. of Zoology, Grad. Sch. of Sci., Kyoto Univ.)

Introduction

【9:00】

2S16-1 【9:03】

Yoshiko Takahashi（Dept. of Zoology, Grad. Sch. of Sci., Kyoto Univ.）

Cell communications during skin pigmentation

Yoshiko Takahashi1, Hidetaka Murai1, 2, Kenichiro Sakai2, Ryosuke Tadokoro1,（1Dept. of Zoology, Grad. Sch. of Sci.,
Kyoto Univ., 2Dept. of Bio. Sci., NAIST）

2S16-2 【9:28】

Trunk or tail: the changing lives of axial progenitors

Moises Mallo（Instituto Gulbenkian de Ciencia, Oeiras, Portugal）

2S16-3 Interaction between organisms and the environment: developmental regulation of polyphenism【10:03】

Teiya Kijimoto, Armin P. Moczek（Dept. of Biology, Indiana Univ.）

2S16-4 
Dynamics of mouse sperm stem cells: How is the tissue homeostasis maintained?

【10:28】

Shosei Yoshida（Div. of Germ Cell Biol., Natl. Inst. Basic Biol.）

2S16-5 
The fluid dynamics of collective cell migration【10:53】Roberto Mayor（Dept. Cell and Dev. Biol., University College London）

Conclusion

Shosei Yoshida（Div. of Germ Cell Biol., Natl. Inst. Basic Biol.）

2S17

第17会場（5階 503）
Minoru Yoshida Presents
At the Molecular Crossroad of Metabolism and Epigenetics【11:28】9:00-11:30【E】

Organizer：Minoru Yoshida (RIKEN)

Introduction

【9:00】

2S17-1 【9:02】

Minoru Yoshida（RIKEN）

Sirtuin-catalyzed deacylation: Interdependence of metabolism and the epigenome

John M. Denu（Dept. of Biomolecular Chemistry, and the Wisconsin Institute for Discovery, Univ. of Wisconsin,
Madison, USA）

The 37th Annual Meeting of the Molecular Biology Society of Japan61

シンポジウム 第２日目

So Iwata1,2, Kanako Kimura1, Tatsurou Shimamura1, Eriko Nango2, Tomoyuki Tanaka2, Tomohiro Nishizawa8, Osamu
Nureki8, Rie Tanaka2, Mamoru Suzuki2,7, Tetsuya Masuda2,9, Michihiro Sugahara2, Tono Kensuke3, Yasumasa Joti3,
Takashi Kameshima3, Changyong Song2, Takaki Hatsui2, Makina Yabashi2, Keitaro Yamashita2, Toshiaki Hosaka4,
Hiroaki Tanabe4, Masakatsu Hato4, Toshi Arima4, Someya Tomomi4, Mikako Shirouzu4, Dongqing Pan5, Toru
Nakatsu5, Hiroaki Kato5, Eiichi Mizohata6, Yu Kitago7, Junichi Takagi7, Yasuaki Yamanaka1, Takaaki Fujiwara1,
Ayumi Yamashita2, Jyun Kobayashi2（1Graduate School of Medicine, Kyoto University, 2Riken SPring-8 Centre, 3Japan
Synchrotron Research Institute, 4RIKEN Center for Life Science Technologies, 5Graduate School of Pharmaceutical
Sciences, Kyoto University, 6Graduate School of Engineering, Osaka University, 7Institute for Protein Research, Osaka
University, 8Graduate School of Science, the University of Tokyo, 9Graduate School of Agriculture, Kyoto University）

シンポジウム

第 2 日目11 月 26 日（水）2S17-2 【9:42】
PKA-dependent Association of Histone Demethylase JMJD1A with SWI/SNF and PPARγ Alters Chromatin
Dynamics and Thermogenesis in Brown Adipocytes
Juro Sakai（Div. of Metabolic Medicine, RCAST）

2S17-3 【10:09】Epigenomics in Chronic Diseases

シンポジウム 第２日目

Takeo Kubota1, Kunio Miyake1, Natsuyo Hariya1, Kazuki Mochizuki2（1Department of Epigenetic Medicine, Facultyof Medicine, University of Yamanashi, 2Department of Local Produce and Food Sciences, Faculty of Life andEnvironmental Sciences, University of Yamanashi）

2S17-4 
Function of methionine adenosyltransferase II in plasma cell differentiation【10:36】

Kyoko Ochiai1,2, Yasutake Katoh1, Hiroki Shima1,2, Kazuhiko Igarashi1,2（1Dept. Biochem., Grad. Sch. of Med., Tohoku
Univ., 2CREST, JST）

2S17-5 Intestinal microbiota regulates the mucosal immune system through epigenetic modifications【11:03】

Koji Hase（Dept. of Biochem., Faculty of Pham., Univ. of Keio）

62

第 37 回日本分子生物学会年会

シンポジウム

第 3 日目11 月 27 日（木）第3日目11月27日（木）3S1

9:00-11:30【E】

第1会場（1階 メインホール）
Mikiko C. Siomi Presents
Molecular Biology of Non-coding RNAs and its Application
Organizer：Mikiko C. Siomi (Dept. of Biol. Sci. Grad. Sch. of Sci. Univ. of Tokyo)

Introduction

【9:00】

Mikiko C. Siomi（Dept. of Biol. Sci. Grad. Sch. of Sci. Univ. of Tokyo）

3S1-1 【9:02】

Transcriptome wide mapping of Msi1-RNA interaction in neural stem cell
1

2

1

1

2

Masato Yano , Robert B. Darnell , Hideyuki Okano （ Keio University, The Rockefeller University）

3S1-2 The Biology of CRISPRs: From Genome Defense to Genomic Engineering【9:24】

Jennifer A. Doudna（Dept. of Molecular and Cell Biology & Chemistry, University of California, Berkeley）

3S1-3 【9:59】

Hiroshi Asahara1,2,4,5, Tempei Sato1,2,3, Masafumi Inui2（1Dep. of Syst. BioMed., Grad. Sch. of Med., Tokyo Med. Dent.
Univ, 2Dep. of Syst. BioMed., Nat. Res. Inst. for Child Health and Dev., 3JSPS research fellow, 4CREST, JST, 5TSRI,
USA）

3S1-4 Reconstitution of Death Star, a RISCy Business【10:22】

Qinghua Liu（Dept. of Biochemistry, UT Southwestern Medical Center, USA）

3S1-5 Specification of cluster loci in the genome for piRNA production【10:45】Zhao Zhang1, Phillip Zamore2, Zhiping Weng3, William Theurkauf4（1Department of Embryology, Carnegie
Institution for Science, 2Department of Biochemistry and Molecular Pharmacology and HHMI, University of
Massachusetts Medical School, 3Program in Bioinformatics and Integrative Biology, University of Massachusetts
Medical School, 4Program in Molecular Medicine, University of Massachusetts Medical School）

3S1-6 Biogenesis of PIWI-interacting small RNAs in Drosophila【11:08】

Mikiko C. Siomi（Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo）

3S2

第2会場（3階 301）
Stem Cell Production and Organ Regeneration as an Adaptive Reprogramming Strategy

9:00-11:30【E】

Organizers：Keiko Sugimoto (RIKEN CSRS)
Yosuke Tamada (National Institute for Basic Biology)

Introduction

【9:00】

3S2-1 【9:05】

Keiko Sugimoto（RIKEN CSRS）

A qualitative shift of adult pluripotent stem cell state during regeneration in planarians
Norito Shibata, Hayoung Lee, Kiyokazu Agata（Grad. Sch. of Sci., Kyoto Univ.）

3S2-2 What determines differences in cardiac regenerative abilities between mouse and newts?

【9:30】

Takashi Takeuchi, Shoji Tane, Hitomi Okayama, Aiko Ikenishi, Yuki Amemiya, Akira Matsumoto, Ayumi Myouga,
Syohei Azuma, Toshinori Hayashi（Sch. of Life Sci., Faculty of Med., Tottori Univ.）

The 37th Annual Meeting of the Molecular Biology Society of Japan63

シンポジウム 第３日目

The critical role of miRNAs at the edge of Hox-code during skeletal development

シンポジウム

第 3 日目11 月 27 日（木）3S2-3 【9:55】

Epigenome analysis of the stem-cell formation in the moss Physcomitrella patens

Yosuke Tamada1,2, Tetsuya Kurata3,4, Masayuki Hattori5,6, Yutaka Hayano5,7, Shin Oya5, Yasuhiro Kamei2,6, Yuji
Hiwatashi1,2, Yukiko Kabeya1, Tomoaki Nishiyama3,8, Takashi Murata1,2, Mitsuyasu Hasebe1,2,3（1Div. Evol. Biol., Natl.
Inst. Basic Biol., 2Sch. Life Sci., Grad. Univ. Adv. Stud., 3ERATO, JST, 4Grad. Sch. Biol. Sci., Nara Inst. Sci. Tech.,
5
Subaru Telescope, Natl. Astron. Obs. Jpn., 6SBI, Natl. Inst. Basic Biol., 7Sch. Phys. Sci., Grad. Univ. Adv. Stud., 8Adv.
Sci. Res. Cntr., Kanazawa Univ.）

3S2-4 【10:20】

Epigenetic control of cellular reprogramming in plants

Momoko Ikeuchi, Akira Iwase, Keiko Sugimoto（RIKEN CSRS）

3S2-5 【10:45】The Trajectory of Transdifferentiating Cells in the Plant Root

Kenneth D Birnbaum, Idan Efroni, Tal Nawy, Alison Mello, Pui-Leng Ip, Ramin Rahni, Nicholas DelRose（Center for
Genomics and Systems Biology, Biology Department, New York University）

3S3

9:00-11:30【E】

シンポジウム 第３日目

第3会場（3階 302）
Biological Evolution and Diversity
Organizers：Fumitoshi Ishino (Dept. of Epigenet., Med. Res. Inst., Tokyo Med. Dent. Univ.)
Yoshihiko Umesono (Grad. Sch. of Life Sci., Univ. of Hyogo)

3S3-1 Diversity of head regenerative ability along the anterior-posterior axis among planarian species【9:00】

Yoshihiko Umesono（Grad. Sch. of Life Sci., Univ. of Hyogo）

3S3-2 【9:25】

The amphioxus and beyond: genome evolution for vertebrate innovations

Jordi Garcia-Fernàndez （Departament de Genètica, Fac. Biologia, Universitat de Barcelona）

3S3-3 【9:50】

Mammalian Evolution Promoted by Exaptation of LTR Retrotransposons

Fumitoshi Ishino1, Tomoko Kaneko-Ishino2（1Dept. of Epigenet., Med. Res. Inst., Tokyo Med. Dent. Univ., 2Sch. of
Health Sci., Tokai Univ.）

3S3-4 【10:15】

Endogenization of betaretroviruses which are involved in placentation

Takayuki Miyazawa1, Yuki Nakaya2（1Inst. for Virus Res., Kyoto Uni., 2Kyoto Prefect. Univ. of Medicine）

3S3-5 【10:40】Role of retrotransposon in brain development and function
Alysson Muotri（Univ. of California, San Diego）

3S3-6 Acquisition of genetic variability through interbreeding in Homo sapiens【11:05】

Ken-ichi Shinoda（Natl. Mus. of Nat. and Sci. Dept. Antrop.）

3S15

第15会場（5階 501）
Fumiko Toyoshima Presents
Cell Fate Decision and Tissue Homeostasis by Symmetric and Asymmetric Cell Division

9:00-11:30【E】

Organizer：Fumiko Toyoshima (Inst. Virus Res., Kyoto Univ.)

Introduction

【9:00】

3S15-1 【9:05】

Fumiko Toyoshima（Inst. Virus Res., Kyoto Univ.）

Molecular mechanisms for ECM-dependent oriented cell division
Fumiko Toyoshima（Inst. Virus Res., Kyoto Univ.）

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第 37 回日本分子生物学会年会

シンポジウム

第 3 日目11 月 27 日（木）3S15-2 【9:30】

Regulation of asymmetric cell division by Wnt signaling in C. elegans
Hitoshi Sawa1,2（1NIG, 2Sokendai）

3S15-3 【10:00】The feedback signaling from neurons to neural stem cells

Atsunori Shitamukai1, Tomomi Shimogori2, Akihiro Goto3, Shinji Takada4, Michiyuki Matsuda3, Fumio Matsuzaki1（1RIKEN CDB , 2RIKEN BSI, 3Grad. Sch. of Biostudies., Kyoto Univ., 4Div. of Mol. and Dev. Biol., NIBB）

3S15-4 【10:25】Cell fate control via asymmetric cell division in normal and malignant hematopoiesis

Takahiro Ito（Dept. of Biochem. and Mol. Biol., Coverdell Center for Biomed. and Health Sci., Univ. of Georgia）

3S15-5 【10:55】

Mechanism and Functions of Spindle Orientation in the Epidermis

Lindsey Seldin, Terry Lechler（Departments of Dermatology and Cell Biology, Duke University Medical Center）

Conclusion

【11:25】

Fumiko Toyoshima（Inst. Virus Res., Kyoto Univ.）

第16会場（5階 502）
Katsuhiko Shirahige Presents
Epigenetic Dysregulation and Disease

9:00-11:30【E】

Organizer：Katsuhiko Shirahige (The University of Tokyo Institute of Molecular and Cellular Biosciences)

Introduction

【9:00】

3S16-1 【9:10】

Hiroyuki Aburatani（Genomescience, RCAST, Univ. of Tokyo）

Mutations of epigenetic modifiers in cancer

Hiroyuki Aburatani（Genomescience, RCAST, Univ. of Tokyo）

3S16-2 【9:35】

Epigenetic alterations that underlie gliomagenesis and gliomas progression
Akitake Mukasa（Dept. of Neurosurg., Faculty of Med., Univ. of Tokyo）

3S16-3 
Epigenetic regulation of stem cells in acute myeloid leukemia: Essential roles of the IDH mutation【10:00】

Issay Kitabayashi（Div. Hematological Malignancy, Natl. Cancer Ctr. Res. Inst.）

3S16-4 Congenital intellectual disability syndromes arising from mutations of epigenetic regulators【10:25】

Naomichi Matsumoto（Dept of Hum Genet, Yokohama City Univ Grad Sch Med）

3S16-5 
Mechanism of Transcriptional Dysregulation in Cohesinopathies【10:50】

Kosuke Izumi（Research Center for Epigenetic Disease, IMCB, Univ. of Tokyo）

Discussion

【11:15】Conclusion

【11:20】Katsuhiko Shirahige（The University of Tokyo Institute of Molecular and Cellular Biosciences）

第17会場（5階 503）
3S17
Yoshinori Watanabe Presents
Molecular Mechanisms of Chromosome Segregation

9:00-11:30【E】

Organizer：Yoshinori Watanabe (Inst. of Mol. Cell. Biosci., Univ. of Tokyo)

Introduction

【9:00】The 37th Annual Meeting of the Molecular Biology Society of Japan

65

Yoshinori Watanabe（Inst. of Mol. Cell. Biosci., Univ. of Tokyo）

シンポジウム 第３日目

3S16

シンポジウム

第 3 日目11 月 27 日（木）3S17-1 【9:02】

Mechanisms of Chromosomal Instability in Human Cancer Cells

Duane A. Compton（Dept. Biochem, Geisel School of Medicine at Dartmouth）

3S17-2 【9:37】An origin of chromosome missegregation in mitosis
Toru Hirota（Div. Exp. Pathol., Cancer Inst., JFCR）

3S17-3 
The inner centromere-shugoshin network prevents chromosomal instability【10:02】

Yuji Tanno, Hiroaki Susumu, Yoshinori Watanabe（Inst. of Mol. Cell. Biosci., Univ. of Tokyo）

3S17-4 【10:27】

Joining centrosomes and how to disjoin them to get a mitotic spindle
Elmar Schiebel（Ctr. Mol. Biol., Univ. of Heidelberg）

3S17-5 【11:02】Evolutionary landscape of condensin-based chromosome architecture
Tatsuya Hirano（Chromosome Dynamics Laboratory, RIKEN）

シンポジウム 第３日目

Conclusion

【11:27】

Elmar Schiebel（Ctr. Mol. Biol., Univ. of Heidelberg）

CSHA session

13:15-15:45【E】

第17会場（5階 503）
Frontiers in Computational Biology

Organizer：Michael Q. Zhang (Center for Systems Biology, MCB, Univ. of Texas - Dallas; Center for Synthetic
and Systems Biology, TNLIST, Tsinghua University)

Introduction about Cold Spring Harbor Asia

【13:15】

CSHA-1 【13:25】Maoyen Chi（Cold Spring Harbor Laboratory / CSH Asia）

Alu Repetitive Elements as Proto-Enhancers

Jing-dong Jackie Han（CAS-MPG Partner Institute for Computational Biology）

CSHA-2 Computational Advances in ChIP-seq and ChIA-PET Data Analysis【13:50】Michael Q. Zhang（Center for Systems Biology, MCB, Univ. of Texas - Dallas; Center for Synthetic and Systems
Biology, TNLIST, Tsinghua University）

CSHA-3 
Metabolomics and Multi-omics Systems Biology【14:15】Masaru Tomita（Institute for Advanced Biosciences, Keio University）

CSHA-4 
Finding collaborating transcription factors using ChIP-seq【14:40】Wing-kin Sung1,2（1Dept. of Computer Science, National University of Singapore, 2Genome Institute of Singapore）

CSHA-5 Regulatory RNA【15:05】

Nikolaus Rajewsky（Max Delbrueck Center for Molecular Medicine）

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第 37 回日本分子生物学会年会