Novo Nordisk Innovation Summit, The University of Tokyo, The Institute of Medical Science, Auditorium ar 1st Building, 4-6-1 Shirokanedai Minato-ku. Tokyo, Japan
1 October 20140845-0900
0900-0915

Speakers
Professor Hiroshi Kiyono (Tokyo) and Dr Anand Gautam (Novo Nordisk) - Welcome
Søren Bregenholt, Corporate Vice President, R&D External Relations, Novo Nordisk, Denmark Introduction to Novo Nordisk

Chair: Matthias von Herrath0915 - 1000

Marc Feldmann, Kennedy Institute of Rheumatology, Oxford, UK

1000 - 1045

Tadamitsu Kishimoto, Professor, Immunology Frontier Research Center, Osaka University,

1045 -1100

Coffee break

Chair: Atsushi Kumanogoh

1100 - 1130
1130 - 1200

Sho Yamasaki, Research Center for Infectious Diseases,

Shizuo Akira, Immunology Frontier Research Center, Osaka University, Japan

1230 - 1330

Lunch

Chair: Hisashi Arase1330-1400

Kiyoshi Takeda, Graduate School of Medicine, Osaka University, Japan

1400-1430

Hiroshi Kiyono, Division of Mucosal Immunology, The University of Tokyo, Japan
Koji Hase, International Research and Development Center for Mucosal Vaccines, The

1500-1520

University of Tokyo, Japan
Naoko Satoh-Takayama, Unit of Innate Immunity, Pasteur Institute, France

1520-1535

Coffee break

Chair: Sho Yamasaki
1535-1605

Toshiaki Ohteki, Medical Research Institute, Tokyo Medical and Dental University, Japan

1605-1635

Toshinori Nakayama, Graduate School of Medicine, Chiba University, Japan
Satoshi Uematsu, Division of Innate Immune Regulation, Institute of Medical Science, The

1635-1705
1705-1725

University of Tokyo, Japan
Yosuke Kurashima, Division of Mucosal Immunology, The University of Tokyo, Japan

1900-2100

Dinner at Sheraton Miyako Hotel

2 October 2014

Immune regulation through C-type lectin receptors
Regnase-1, an endoribonuclease involved in the immune response
Mucosal Immunity and Inflammation
Regulation of gut homeostasis by colonic epithelial cells
Mucosal links between innate-epithelial cells and commensal flora for the development of new immune-prevention and -therapy
Microbiome: immunity and inflammation
Mucosal ILCs and Tcells for intestinal homeostasis

Innate and Acquired Immune Responses for Immunity and Diseases
Novel source of dendritic cells, the control tower of the immune system
Effector T cell diferentiation for allergic responses
Innate immune responses in radiation-induced intestinal injury
Tissue-specific signals control mast cell function for maintenance of tissue homeostasis

Speakers
Chair: Kensuke Miyake

1000 - 1030

Atsushi Kumanogoh, Graduate School of Medicine, Osaka University, Japan1030 - 1100

Hisashi Arase, Immunology Frontier Research Center, Osaka University, Japan

1100 - 1130

Masaaki Murakami, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan

1130- 1230

Lunch

Chair: Masaaki Murakami
1230 - 1300

Shimon Sakaguchi, Immunology Frontier Research Center, Osaka University, Japan

1300 - 1330

Takashi Saito, RIKEN Research Center for Allergy & Immunology, Yokohama, Japan

1330 - 1350

Yohko Kitagawa, Immunology Frontier Research Center, Osaka, Japan

1350 - 1420

Kazuhiko Yamamoto , Graduate School of Medicine, The university of Tokyo, Japan

1420 -1450

Coffee break

Chair: Anand Gautam

1450 - 1520

Innate Immunity for Immune Responses and Inflammation

Medical Institute of Bioregulation, Kyushu University, JapanKensuke Miyake, Department of Microbiology and Immunology, The University of Tokyo, Japan Mechanisms regulating RNA sensing by TLR71200 - 1230

1430-1500

Immunology Icon Lecture on: Anti-TNFa and Anti-IL6 Therapies & Beyond
Therapy for 21st century: how can we get closer to a cure for rheumatoid arthritis?
IL-6: from its discovery to the development of TocilizumabYoichiro Iwakura, Research Institute for Biomedical Sciences, Tokyo University of Science,Chiba, Japan

1520 - 1550

Eiji Esashi, Ginkgo Biomedical Research Institute (GBRI) of SBI Biotech, Tokyo, Japan

1550 - 1620

Yasunori Okada, Graduate School of Medicine, Keio University, Japan

1620-1630

Hiroshi Kiyono, Division of Mucosal Immunology, The University of Tokyo, Japan

New Pathological Molecules and Cells for Inflammation
Pathological implications of semaphorins and mitochondrial DNAs
Cellular misfolded proteins transported to the cell surface by MHC class II molecules are targets for autoantibodies
Roles of the inducer of inflammation in non-immune cells
Critical Role of T Cells for the Balance between Tolerance and Inflammation
Control of Treg cells for immune tolerance
Regulation of initial T cell activation and functional differentiation
The genome organizer Satb1 differentially controls thymic and peripheral development of regulatory T cells
TGF-beta3 expressing CD4+CD25-LAG3+ regulatory T cells control humoral immune responses
New Target Molecules and Cells for the Control of Inflammation
The role of DCIR in maintaining the homeostasis of the immune system and the bone
Management of tumor and autoimmune disease by controlling immuno surveillance via regulation of DC activity: use of TLR
modulators and anti-immune system antibodies
ADAMTS4 and ADAMTS5 in inflammation
Final words and conclusion of the meeting