Link to Research Activity
CURRICULUM VITAE
NAME:
BIRTH:AFFILIATION:Shin-Ichiro Karaki
April 21, 1974
Laboratory of Physiology
Graduate Division of Nutritional and Environmental Sciences, Graduate School of Integrated
Pharmaceutical and Nutritional Sciences
University of Shizuoka, Japan

MAJOR RESEARCH INTERESTS:
Gastrointestinal physiology, neuroscience, endocrinology and immunology
EDUCATION:

B. Sc. Faculty of Pharmaceutical Sciences
University of Shizuoka (1998)
M. Sc. Graduate School of Nutritional and Environmental Sciences
University of Shizuoka (2000)
Ph.D. Graduate School of Nutritional and Environmental Sciences
University of Shizuoka (2003)

RESEARCH AND PROFESSIONAL EXPERIENCE:
2003.4-2007.3
Research Associate, Laboratory of Physiology (Prof. Atsukazu Kuwahara), Department ofEnvironmental Health Sciences, Graduate School of Nutritional and Environmental Sciences/ Institute for Environmental Sciences, University of Shizuoka
2007.4-2012.3
Assistant Professor, Laboratory of Physiology (Prof. Atsukazu Kuwahara), Department ofEnvironmental Health Sciences, Graduate School of Nutritional and Environmental Sciences/ Institute for Environmental Sciences, University of Shizuoka
2012.4-present
Assistant Professor, Laboratory of Physiology (Prof. Atsukazu Kuwahara), Department ofEnvironmental Health Sciences, Graduate Program of Integrated Pharmaceutical andNutritional Sciences / Institute for Environmental Sciences, University of Shizuoka[Additional]
2004.10-2004.12
Visiting Researcher, Department of Anatomy and Cell Biology (Prof. John B. Furness),
Faculty of Medicine, Density and Health Sciences, University of Melbourne, Australia
2008.11-2008.12
Visiting Researcher, Department of Biochemistry and Molecular Biology (Prof. Vadivel
Ganapathy), Medical College of Georgia, USA
SELECTED PUBLICATIONS (First and Corresponding Author):
1. Iizuka Y, Kuwahara A, Karaki SI.* Role of PGE2 in the colonic motility: PGE2 generates and enhances
spontaneous contractions of longitudinal smooth muscle in the rat colon. J Physiol Sci (2013 in press).
2. Karaki SI, Kuwahara A. Propionate-induced epithelial K+ and Cl-/HCO3- secretion and free fatty acidreceptor 2 (FFA2, GPR43) expression in the guinea pig distal colon. Pflugers Arch 461: 141-152, 2011.
3. Karaki SI, Kuwahara A. Role of short-chain fatty acids and their receptors in colonic motility. Bioscience
Microflora 29: 31-40, 2010.
4. Karaki SI, Kuwahara A. Free fatty acid receptors and their physiological roles in the colon. Medycyna Wet
66: 147-155, 2010.
5. Karaki SI, Tazoe H, Hayashi H, Kashiwabara H, Tooyama K, Suzuki Y, and Kuwahara A. Expression ofthe short-chain fatty acid receptor, GPR43, in the human colon. J Mol Histol 39: 135-142, 2008.
6. Karaki SI, Kaji I, Otomo Y, Tazoe H, Kuwahara A. The tight junction component protein, claudin-4, is expressedby enteric neurons in the rat distal colon. Neurosci Lett 428: 88-92, 2007.
7. Karaki S, Mitsui R, Hayashi H, Kato I, Sugiya H, Iwanaga T, Furness JB, Kuwahara A. The short chain fatty
acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in the rat intestine. Cell Tissue
Res 324: 353-360, 2006.
8. Karaki S, Kuwahara A. Regulation of intestinal secretion involved in the interaction between neurotransmitters andprostaglandin E2. Neurogastroenterol Motil 16 suppl 1: 96-99, 2004.
9. Hosoda Y,* Karaki S,* Shimoda Y, Kuwahara A. Substance P-evoked Cl- secretion in guinea pig distal colonicepithelia: interaction with PGE2. Am J Physiol 283: G347-G356, 2002. * Contributed equally
10. Karaki S, Hosoda Y, Kadowaki M, Kuwahara A. Effects of adenosine or 5-HT-evoked ion transport in guinea pig

distal colon. In: FALK SYMPOSIUM 112 Neurogastroenterology From the Basics to the Clinics. Krammer HJ, andSinger MV (eds), Kluwer Academic Publishers, 251-254, 2000.