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Contract Services

Contract purification --------------------------------168-169

17Contract Services

Contract purification
With all chromatographic experiences that we have accumulated since establishment of YMC, we offer fee-based method
development and purification services. The fields we can support are, but not limited to, pharmaceutical, food, electrochemical
and natural product. YMC has variety of packing materials, various chromatography skids/dynamic axial compression columns,
GMP compliant purification plant and most importantly talented skilled human resources. YMC provides the most efficient method
development/purification services in terms of time and cost by combining those resources.

Advantages of contract purification
Separation and purification using chromatography can require advanced technology, time, and cost. YMC provides purification services
with our accumulated experience, know-how, and excellent equipment. In addition to ensuring qualification of a target substanceaccording to your request, we will also propose an efficient separation method that may result in a cost reduction.

Customer
Difficulty in purification method
optimization
Expensive columns and packing
materials for purification
No systems and facilities for
preparative purification
Shortage of time and labor

Outsourcing to YMC
Accumulated experience andknow-how of separation andpurification
Low-cost columns and packing
materials manufactured in-house
Large columns and preparative
systems are available

High Purity Compounds
Quick Service
High Reliability
Low-Cost

Applicable scale
GMP: grams to tons

non-GMP: milligrams to tons

・Seamless scale up according to the development stage.
・Easy transfer of the purification method and system to the customer’s facility.

Contract Services
168Inner diameter ofthe column

20 mm

50 mm

450 mm1000 mm

R&D

Purification purpose

Productionmg

Scale

tonFlow of purification service
We respond flexibly to your need including confidentiality, GMP requirements, and budget.
Please feel free to ask for consultation about purification of any scale from small production to mass production.
■ Consultation■ Signing a non-disclosure agreement

Purification Request■ Preliminary study of the sample provided

Preliminary Study Report■ Proposal and confirmation of the optimal column andthe most efficient preparative separation method■ Submission of a quote according to the result ofSubmission of a quote

the preliminary study■ Preparative purification with the optimal method

Purification■ Purity test

Delivery of Purified Productand Submission of Report
Target substances

・Oligonucleotides
・Achiral compounds

・Peptides
・Active pharmaceutical ingredients (API)・Proteins
・Impurities

・Chiral compounds
etc.

Facilities and quality assurance system
Our GMP compliant API Purification Plant is equipped with large scale
preparative HPLC systems and dynamic axial compression columns aswell as a lyophilizer and various analytical instruments. Low-costpurification can be achieved by utilizing in-house products such as
preparative chromatography systems, packing materials, and columns
along with our experience and know-how in chromatography purification.
We also established GMP quality management system for appropriate
manufacturing control and quality control. Our quality assurance andquality control units are independent from our manufacturing control
units, ensuring product quality and maintaining the quality system.

API Purification Plant

Contract Services

SMB preparative system

Dynamic axial compression HPLC column

Preparative HPLC system

169