2013 GORDON RESEARCHCONFERENCE ON POLYAMINES&2013 GORDON RESEARCHSEMINER : POLYAMINES
Program[SUNDAY June 16, 2013]
Polyamines in New Arenas of Biology: Stem Cells, Aging and Therapy
Discussion Leader: Keiko Kashiwagi (Chiba Institute of Science)
Leah Vardy (Institute of Medical Biology)"A role for polyamine regulators in embryonic stem cell self-renewal anddifferentiation"
Mitsuharu Matsumoto (Kyodo Milk Industry Co. Ltd.)"Promotion of longevity due to upreguration of gut bacterial polyamineproduction"
Robert Casero (Johns Hopkins University)"Amine oxidases: Potential targets for prevention and therapy"[MONDAY June 17, 2013]
Translational Control
Discussion Leader: Anthony Pegg (Pennsylvania State University Collegeof Medicine)

R. Jurgen Dohmen (University of Cologne)"Polyamine-mediated regulation of ornithine decarboxylase antizyme"
Myung-Hee Park (NIH)"Role of polyamines and eIF5A in eukaryotic translation"
Salim Merali (Temple University School of Medicine)"Modulation of SSAT Translation"
Jian-Ying Wang (University of Maryland School of Medicine)"Translational regulation through RNA-binding proteins andmicroRNAs by polyamines controls gut epithelial homeostasis"
4:00 pm - 6:00 pm
Poster Session
Roles of Polyamines in Metabolism and Disease
Discussion Leader: Enzo Agostinelli (University of Rome)
Raghu Mirmira (Indiana University School of Medicine)"Polyamines and hypusine in diabetes pathogenesis and treatment"
Short Talk: Shirly Brenner (Weizmann Institute of Science)"Inhibition of adipogenesis by polyamine depletion, a mechanisticinsight"
Keith T. Wilson (Vanderbilt University)"Epidermal growth factor activation and polyamines in Helicobacter
pylori-induced DNA damage and gastric carcinogenesis"
Kazuei Igarashi (Chiba University)"Toxicity of acrolein produced from polyamines during brain infarction"[TUESDAY June 18, 2013]
Polyamine Transport and Ion Channel Functions
Discussion Leader: Heather Wallace (University of Aberdeen)
Richard Poulin (Laval University)"MBGR-1, a novel antizyme-like repressor of mammalian polyamine

transport"
Miki Fujita (RIKEN)"Transport of paraquat in plants is mediated by a polyaminetransporter"
Jacqui Gulbis (WEHI)"Polyamine binding in the conduction pathway of Kir channels and what
it reveals: A changing perspective on pore gating"
Pierre Paoletti (INSERM)"Molecular action of extracellular polyamines on NMDA receptors"
Therapeutic Development and Applications
Discussion Leader: Alex Khomutov (Russian Academy of Sciences)
Patrick Woster (University of South Carolina)"Epigenetic modulation with synthetic polyamine analogues as atherapeutic strategy"
Margaret Phillips (UT Southwestern)"Regulatory control of polyamine biosynthesis in Trypanosoma brucei"
Alex Khomutov (Russian Academy of Sciences)"Methylated and charge-deficient polyamine analogues"[WEDNESDAY June 19, 2013]
Polyamines in Cancer Development and Therapy
Discussion Leader: David Feith (Penn State College of Medicine)
Susan K. Gilmour (Lankenau Institute)"Polyamines promote tumorigenesis by generating an
immunosuppressive microenvironment"
Jonas Nilsson (University of Gothenburg)

"Role of polyamines in Myc-induced lymphoma"
Lisa Shantz (Penn State College of Medicine)"Keratinocyte differentiation and expansion in mice with alteredpolyamines"
Frank L. Meyskens (UC Irvine)"Followup studies of DFMO plus sulindac for colorectal cancer
prevention and the use of DFMO for non-melanoma skin cancer andprostate cancer prevention"
4:00 pm - 6:00 pm
Poster Session
Roles of Polyamines in Bacterial Physiology and Pathogenesis
Discussion Leader: Anthony J. Michael (University of TexasSouthwestern)
Ilana Kolodkin-Gal (Weizmann Institute)"Polyamines play key role in the breakdown of bacterial biofilms"
Shin Kurihara (Emory University School of Medicine)"Putrescine importer PlaP contributes to swarming motility andurothelial cell invasion in Proteus mirabilis"
Anthony J. Michael (University of Texas Southwestern)"The diversity of bacterial polyamine biosynthesis and function"[THURSDAY June 20, 2013]
Cancer Therapeutic Trials Targeting the Polyamine Pathway
Discussion Leader: John L. Cleveland (Scripps Florida)
Michael D. Hogarty (University of Pennsylvania)"Polyamine antagonist therapeutics for the pediatric cancer
neuroblastoma"Andre Bachman (University of Hawaii)"DFMO in pediatric neuroblastoma: Latest progress on Phase I andPhase II clinical trials"
Eric A. Lightcap (Millennium Pharmaceuticals)"Dysregulation of polyamines is the mechanism of cell death byproteasome inhibition"
4:00 pm - 6:00 pm
Poster Session
Keynote Session: How do polyamines do it?
Discussion Leader: Chaim Kahana (Weizmann Institute)
TBA (Presentations from GRS or Poster Sessions)
Keynote Speaker: Eugene Gerner (Arizona Cancer Center)"How do polyamines do it?"
[FRIDAY June 21, 2013]
9:00 am
Departure