Bussey-Saksida
Touch Screen Systems for Rodents
A Translational Cognition Task Battery

Paired Associate
Learning Task
Five Choice Serial
Reaction Time Task

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WHAT IS THE BUSSEY-SAKSIDA SYSTEM?
Modular, adjustable design allows for high throughput screening.
Unique Trapezoidal
Wall focuses animalattention

High Resolution
Touch Screen
Display

Food/Liquid Reward Troughaccomodates headstages
and can be reconfigured for
Autoshaping task

Laser-cut floor for easeof reconfiguration

Bussey-Saksida
Touch Screen Chamberfor Mice

Ambulatory IR Beams
pass through enclosure wallsA Focused Approach
The Bussey-Saksida Rodent Touch Screen Chamber (TCN Lab: Cambridge; University of Western Ontario) is theevolution of the operant chamber. Our chambers are designed for the efficient and high-throughput cognitive evaluationof rodents. For these systems, we offer many standard paradigms, prewritten to include the entire battery of tasks necessary
to habituate, shape, and bring the animal to criteria on that particular application, as well as collect and analyze prepared DataAnalysis Sets.
• The Bussey-Saksida Chamber has a unique trapezoidal wall shape that focuses the animal’s attention and is made fromparts that simply slot together. The chamber can also be configured to a modular square chamber with panels, levers, lights,
and a range of other operators.
• The reward tray can be moved to a position in front of the screen for tasks such as Pavlovian Autoshaping, and to the rear of
the chamber for tasks such as Pairwise / Visual Discrimination.
• Not just a touch screen, this is the ultimate modular chamber for high throughput. For example, the system is easily
reconfigured to do Visual Discrimination and Reversal in the morning and Five Choice Serial Reaction Time Task in theafternoon.
All Bussey-Saksida Touch Screen hardware conforms to a single technical standard. This standard defines
all aspects of the animal’s interactions. Due to the complexity of touch screen system hardware, electronics,and software this standard ensures conformity. Comparisons are valid and simple to carry out. Fulldocumentation for the CAMTOUCH Technical Standard is available upon request or by visiting ourwebsite.

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COMPLEXITY MADE SIMPLE
Delivered ready to work.
Easy-Install System
The Easy-Install keeps your lab organized by hiding the many cables in trunking and thewhole system easily moveable for cleaning. Designed as a factory built, pre-cabled systemthat can be taken from a transit crate in one piece and wheeled into place, the EasyInstall eliminates the effort needed to handle, move, and install individual stations and theirconnections to the system interface and control.
Computer and Interface connections are easily made as all cables are routed to the PC
location, above the cubicles. The user’s monitor, keyboard and mouse can be located awayfrom the system as needed. Note: Computer and Interface are not part of the Easy-Install theseare purchased separately. Workstation monitor, keyboard, and extra length cables are also soldseparately.
Our Isolation Chambers were designed in consultation with the Institute of Sound and Vibration at the University ofDerby England to provide a controlled environment for sound, light, and electromagnetic interference. Ergonomically designed
for ease of animal handling and welfare with a ventilation fan and optional rolling shelf, these chambers can be configured
with a house light, speaker, and camera observation/recording system that uses visual or IR illumination. Audible transmission
measurements were performed on sound pressure z-scale. Attenuation level ensures that sound between chambers isattenuated to around 35 DB which approximates to the background noise in a quiet room.
Isolation Chambers are optionally available with built-in electromagnetic
compatibility, to ensure artifact free in-vivo recording. Potential artifacts
are eliminated at the source by shielding against electromagnetic output orby reducing the emissions at the component level on the printed circuit board.
This is achieved by superior electronic engineering design and testing with aspectrum analyzer. Other Features include:• Faraday cage built into the sound isolation cubicle, with emc gasketed doorand baffles at the air vent apertures• Low emission electronic components and p.c.b. design to reduce
electromagnetic emission at source• EMC Shielded touch screen: no loss of sensitivity or image clarity

Customized system integrations are available upon request.

Need to Know More?
Touch Screen Webinar
Our full Touch Screen webinar entitled “Using Touchscreen Operant Systems to Study
Cognitive Behaviors in Rodents” is available from InsideScientific, by scanning this codeon your mobile device or visiting this link: https://youtu.be/JBh5BJ-kUuA

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OPERANT CONTROL SOFTWARE
Sophisticated and user-friendly software makes controlling your chamber easy!

• Designed to be easy to use andintuitive for building Behavioral
Studes• Flexible Software controls
Acquisition, Control, and DataAnalysis• Use pre-written tasks, write yourown tasks, or adapt pre-writtentasks for your needs

ABET II Touch and ABET II VideoTouch Operant Control Software
The standard Bussey-Saksida applications have been created using ABET II series of software. Standard paradigms or schedules
are packaged in a format that the user may edit and modify. The images used in the standard applications are also available foruse in new schedules created by the user, or user generated images (or videos) may be added to the image list. Every effort has
been made to make this intuitive and logical to the non-programmer, but we are on stand by, ready to assist in your efforts toproduce original research.

Virtual Interface
Install ABET II Touch on your laptop, office computer or any computer not connected tohardware and use the Virtual Interface as a duplicate of the environment that you have in yourlab. Write/program, review, and test schedules or analyze lab data while disconnected from thelab hardware or offline. Schedules and data are easily passed to and from your lab via a network
connection or any removable media.

Contact us for a demonstration!

Translational to NHP and Human Tasks with Whisker® Multimedia
ABET II Touch and ABET II VideoTouch rely on the Whisker operating system to control the advanced graphical output on
multiple screens, and touch screen input from multiple chambers when running the Bussey-Saksida Rodent Test Chambers. Thisis the same underlying platform used in primate and human CANTAB touch screen stations for translational cognitive testing.
Whisker has been cited in over 142 publications across more than 34 journals.

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BENEFITS OF STANDARD PARADIGMS
Prewritten Standard Paradigms with established neuro-pathological relevance.
ABET II Touch allows usage of standard, original, and customized paradigms. Standard Task Paradigms
are available by arrangement with the University of Cambridge. Standard tasks include popular tasks such as
PD, PAL, 5CSRT, Location Discrimination, and many more. All paradigms include training routines as well as
the main experimental paradigm and the data analysis sets. Full descriptions of our standard paradigms
are available upon request or by visiting our website.
NHP/HumanCANTAB EquivalentStandardTasks

Typical time to reach baseline(post-pretraining) RATS

Typical time to reach baseline(post-pretraining) MICE*Example neuralsystems involved

Clinical area showing
impairment

NHP

Pretraining to touch animage and initiate a trial(PD, PAL, LD, VMCL &TUNL)

1-2 weeks

1-2 weeks (e.g., 7-8 week old
C57BL6J mice: 5 days)

Human/NHP

Pairwise / Visual
Discrimination (PD)

5-7 days

5-7 days for young mice

Prefrontal Cortex, Perirhinal
Cortex, Striatum, Dopamine
system, Cholinergic system,
NMDA receptors

Huntington's,
Schizophrenia,
Parkinson's

Human/NHP

Paired Associate Learning(PAL)

35-45 sessions to 80%

35-45 sessions to 70%

Hippocampus, Cholinergicsystem, NMDA Receptors,
AMPA Receptors

Alzheimer's,
Schizophrenia

NHP

Visuomotor Conditional
Learning (VMCL)Approximately 20 sessions

Approximately 20 sessions

Dorsal Striatum, Posterior
Cingulate Cortex

Huntington's,
Parkinson's

NHP

Location Discrimination
Learning (LDL)

2-4 weeks

2-4 weeks

Hippocampus, Neurogenesis

Alzheimer's,
Schizophrenia,
Depression

Human/NHP

Trial-Unique Nonmatchingto-Location (TUNL)

Approximately 4 weeks

6-24 Sessions to acquire thebasic task

Hippocampus, Cholinergicsystem, NMDA Receptors

Alzheimer's

Human/NHP

5 Choice Serial Reaction
Time (5CSRT)

30 sessions

Pretraining (ave 10 days) + 3
weeks to 80% @ 2 sec baseline

Prefrontal Cortex, BasalForebrain, Cholinergic(Accuracy), Serotonin(Impulsivity), Noradrenaline(Distraction), Dopamine(Motivation)

Alzheimer's,
Depression,
Huntington's,
Schizophrenia,
ADHD,
OCD

Autoshaping (AUTO)

Several sessions

Several sessions

Ventral Striatum, Amygdala,
Anterior Cingulate Cortex

Huntington'sExtinction (EXT)

Approximately 4 days training + a
few days extinction

Approximately 4 days training + a
few days extinction

5-Choice Continuous
Performance Task(5C-CPT)**

Approximately 24 weeks (based ontraining in 5-hole box)

Approximately 13 weeks (basedon training in 5-hole box) after
training to 5-CSRTT

Dopamine, Serotonin,
Colinergic, Parietal,
Muscarinic.

Schizophrenia, ADHD,
OCD, Alzheimer's

Human/NHP

Rodent Continuous
Performance Task (rCPT)

Approximately 20 days

Approximately 35 sessions

Dopamine, Serotonin,
Colinergic, Parietal,
Muscarinic

Schizophrenia, ADHD,OCD, Alzheimer’s

Human

4-Choice Gambling Task(4C-GT)***

Approximately 20 sessions (basedon training in 5-hole box)

Training times to be confirmed

Dopamine, Serotonin

Bipolar Disorder,Gambling

NHP

Progressive Ratio (PR) Task

Results for rats not yet available

16 weeks from first habituation toreach stable PR performance

Dopamine

Motivation

NHP

*
*****

ADHD, OCD

Depends on strain and age
Young et al, The 5-Choice Continuous Performance Test: Evidence for a Translational Test of Vigilance for Mice. Plosone, January 19, 2009 DOI: 10.1371/journal.pone.0004227
Barnes et al. D1 receptor activation improves vigilance in rats as measured by the 5-choice continuous performance test. Psychopharmacology (Berl). 2012 Mar;220(1):129-41
Zeeb et al. Sertonergic and Dopamine Modulation of Gambling Behaviour as Assessed Using a Novel Rat Gambling Task. Neuropsychopharmacolgy 2009 34,2329
van Enkhuizen et al. Differential effects of dopamine transporter inhibitors in the rodent Iowa Gambling Task: Relevance to mania. Psychopharmacology (Berl). Feb 2013; 225(3): 661–674

Full Paradigm Task Reference and Bibliography is available upon request or by visiting our website.
Selected References
Jared W. Young, J David Jentsch, Timothy J Bussey, Tanya L Wallace, and Daniel M Hutchenson. Consideration of species differences indeveloping novel molecules as cognition enhancers. Neurosci Biobehav Rev. 2013 Nov; 37(9 0 0).
Horner AE, Heath CJ, Hvoslef-Eide M, Kent BA, Kim CH, Nilsson SR, Alsiö J, Oomen CA, Holmes A, Saksida LM, Bussey TJ. The touchscreen
operant platform for testing learning and memory in rats and mice. Nat Protoc. 2013 Oct;8(10):1961-84.

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SYSTEM INTEGRATIONSTurnkey Touch Screen solutions to accomodate every research need.
No Emission
Pellet DispenserVideo Time-Stamp Module
Auto-Retract Tether
Specially designed
Lid and Door toaccommodate
Tethered Headstages

Faraday Cage and EMC Gasket

Shielded Touch Screen
Reward Trough forHeadstages

Rat Touch Screen
Chamber with Shielding,Electrophsiology System,
and Video Integration

Electrophysiology: Fully Integrated with Behavior
Electrophysiology starts with clean signals and animals that freely move due to minimal weight high channel headstages. Our
Electrophysiology systems support both Wireless and Tethered Headstages.
Hardware• Shielding and faraday cage and emission free electronics• Digital headstages, multiplexed and shielded• Unique 64 channel headstage weighs only 1.82g• Microdrives always accessible• Stimulation lines and LED’s• Integrated time-stamped video: Scroll, play, and pause each of 4 chambers• Reciprocal correlation of electrophysiology and behavioral data
64 Channel Digital Headstage
with microdrives always accessible

3rd Party Integration• Display EEG data for correct and incorrect touch• Export data for Spike sorting• Analysis of overlapping regions• Signal-to-noise computations• Available digital referencing

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ABETTrigger 1

Trigger 2

Trigger 3

Trigger 4

Channel 3

Channel 44-Channel Controller

Channel 1

Channel 2

Commutator

Commutator

Blue LED

Red LED

Blue LED

Red LED

Fiber Optic

Fiber Optic

Fiber Optic

Fiber Optic

AnimalAnimalBussey Chamber 1

Bussey Chamber 2

Example 2 Chamber Optogenetic Setup

New Optogenetic-Integrated Bussey–Saksida Touch Screen chambers are now available for single, dual, or four chamber EasyInstall systems. The system has been designed to minimize the torque experienced by the animal while maximizing the light atthe end of the implanted ferrule. Each chamber has independent ABET II linked control over each Optogenetic LED with easily
defined simple or complex light patterns in software.
• Single chamber or Four chamber systems• Flexible 0.5MA fiber cables• 0.66NA 200/230µm Fiber stubs• Maximum LED Outputs measured at the end of a 1m 0.5NA fiber optic cable• Response to Touch Screen: 4 per channel• TTL inputs (START/STOP/PAUSE/UNPAUSE)

Video Tracking Integration• Optimized IR lighting, illuminates subject but minimizes reflection• Chamber design and materials for contrast as well as illumination• No interference with other IR devices• Software accounts for behavioral stim light• Algorithms eliminate touch screen images and reflection• Image contour is captured accurately and without distortion

Working Animal Videos
Many videos portraying various schedule types are available on our website:
https://campdeninstruments.com/downloads/videos

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Contact Us for a Quotation or More Information
Worldwide Office3700 Sagamore Pkwy N
Lafayette, IN 47904
USA
Phone: (765) 423-1505
Fax:(765) 423-4111
sales@lafayetteinstrument.com
www.lafayetteneuroscience.com

European OfficeP.O. Box 8148
Loughborough,Leics. LE12 7XTEngland
Tel: +44 1509 814790
Fax: +44 1509 817701
eusales@lafayetteinstrument.com
www.campdeninstruments.com

The Bussey-Saksida Chambers and WhiskerServer® originate from the department ofProf. Trevor Robbins, Experimental Psychology, University of Cambridge, England.

Copyright © 2014-2017 Lafayette Instrument Company, Inc. All Rights Reserved.

11.6.17

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