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Advanced Clinical Research Center

Division of Advanced Gastroenterology and Endoscopy
先端消化器内視鏡学分野
Professor

Hiroaki Ikematsu, M.D., Ph.D.

教

授博士（医学）

池松弘朗

A new field, “Division of Advanced Gastroenterology and Endoscopy,” wasestablished at the Institute of Medical Science of the University of Tokyo from
October 2023.
Our mission is to conduct cutting-edge endoscopy-related research and develop
novel endoscopic equipment, with a focus on gastrointestinal cancer. In addition,
we will conduct translational research with other research fields at the institute tocreate new diagnoses and treatments.

1. IntroductionAdvances in endoscopic diagnosis and treatment
have been remarkable. Our objective is to continue
advancing, spanning from basic research in endoscopy to clinical investigations, and the creation of innovative endoscopic devices for practical clinical applications. In addition, our objective is to create novel
diagnostic and therapeutic approaches through translational research in collaboration with various fundamental disciplines.
2. Research Activities
The device development in 2023 was as follows:(1) Report on the usefulness of highly quantitative imaging of fecal occult blood, (2) Development of automatic colon insertion endoscope, and (3) Researchtargeting submucosal tumors and gastric cancer by
irradiating with near-infrared light in the wavelength
range of 1,000 nm or more, as well as the developmentof a flexible endoscope for this purpose. All of theseare highly novel seeds and systems that have neverexisted before, and can be expected to be clinicallyuseful.
3. Future Prospects
We will continue basic and clinical research to elucidate, detect, and diagnose lesions with the aim ofpreventing gastrointestinal cancers.
We will continue to develop innovative medical

devices desired by the next generation that reflect theneeds of clinical practice. In the future, we will continue to develop endoscopic equipment and attempt innovative approaches to produce all-new endoscopy
approaches/devices in collaboration with academia
and corporations.
4. Publications
1. Evaluating the identification of the extent of gastric cancer by over-1000 nm near-infrared hyperspectral imaging using surgical specimens. J Biomed Opt. Mitsui T, Mori A, Takamatsu T, KadotaT, Sato K, Fukushima R, Okubo K, Umezawa M,Takemura H, Yokota H, Kuwata T, Kinoshita T,Ikematsu H, Yano T, Maeda S, Soga K. 28(8):086001,2023.
2. Mitsui T, Sunakawa H, Takayama S, Murano T,Shinmura K, Ikematsu H, Yano T. Development ofa novel colorectal endoscopic submucosal dissection training model. Endoscopy. 55(S 01):E808-E810,2023.
3. Nakajo K, Ninomiya Y, Kondo H, Takeshita N,Uchida E, Aoyama N, Inaba A, Ikematsu H, Shinozaki T, Matsuura K, Hayashi R, Akimoto T, Yano T.
Anatomical classification of pharyngeal and laryngeal endoscopic images using artificial intelligence.
Head Neck. 45(6):1549-1557, 2023.
4. Takamatsu T, Endo Y, Fukushima R, Yasue T, Shinmura K, Ikematsu H, Takemura H. Robotic endo-139
scope with double-balloon and double-bend tube
for colonoscopy. Sci Rep. 13(1):10494, 2023.
5. Zhao Y, Peng F, Wang C, Murano T, Baba H, Ikematsu H, Li W, Goel A. A DNA Methylation-based
Epigenetic Signature for the Identification ofLymph Node Metastasis in T1 Colorectal Cancer.
Ann Surg. 277(4):655-663, 2023.

6. Miyazaki K, Wada Y, Okuno K, Murano T, MorineY, Ikemoto T, Saito Y, Ikematsu H, Kinugasa Y, Shimada M, Goel A. An exosome-based liquid biopsy
signature for pre-operative identification of lymph
node metastasis in patients with pathological highrisk T1 colorectal cancer. Mol Cancer. 22(1):