06

Chiral Separation Columns
and Packing Materials

CHIRAL ART------------------------------------------- 62-66
YMC CHIRAL NEA (R), (S)--------------------------------- 67
YMC CHIRAL CD BR -------------------------------------- 67
Ordering Information---------------------------------- 68-69

06

Chiral Separation Columns and Packing Materials
Polysaccharide type

CHIRAL ART
Applicable to various chiral compounds
Applicable from LC/MS microanalysis to large-scale preparative purification
Excellent resolution/durability
High durability column that is suitable for SFC

Particl size: 3, 5, 10, 20 µm
USP L40, L51, L99, L119
*See pp.120-121 for details of SFC column.

HPLC columns/packing materials with polysaccharide derivatives as chiral selectors
CHIRAL ART are HPLC columns/packing materials coated/immobilized with polysaccharide derivatives as chiral selector. CHIRALART immobilized type can be used either in normal- or reversed-phase modes. CHRAL ART are suitable for separations of wide
range of chiral compounds, cis-trans isomers and geometric isomers. Packing materials are available in large quantities (multi kg).

Specifications
Immobilized type
Chiral Separation Columns and Packing Materials

Column/Packing material

Particle size
(μm)

USP
Classification

Chiral selector

CHIRAL ART Amylose-SA

L99
Amylose tris(3,5-dimethylphenylcarbamate)
3,5-Dimethylphenylcarbamate–

CHIRAL ART Cellulose-SB
3
5
10
20

Cellulose tris(3,5-dimethylphenylcarbamate)

CHIRAL ART Cellulose-SC

L119
Cellulose tris(3,5-dichlorophenylcarbamate)

3,5-Dichlorophenylcarbamate–

CHIRAL ART Cellulose-SJ
Cellulose tris(4-methylbenzoate)
Usable mobile
phase

4-Methylbenzoate

Normalphasen-hexane, n-heptane, methanol, ethanol, 2-propanol, acetonitrile, ethyl acetate,tetrahydrofuran, chloroform, t-butyl methyl ether, etc.

Reversedphaseacetonitrile, methanol, ethanol, 2-propanol, tetrahydrofuran, water, aqueous buffer, etc.

Coated type
Column/Packing material

Particle size
(μm)

USP
Classification

Chiral selector

CHIRAL ART Amylose-C Neo

L51
3
5
10
20

Amylose tris(3,5-dimethylphenylcarbamate)
3,5-Dimethylphenylcarbamate

L40

CHIRAL ART Cellulose-C
Cellulose tris(3,5-dimethylphenylcarbamate)
Usable mobile phase*Inquire us for the Amylose-C

62n-hexane, n-heptane, ethanol, 2-propanol, acetonitrile, etc.

Useful for separation of a wide range of chiral compounds
Cetirizine

all-trans-Astaxanthin*2

Phenoxybenzamine
mAU

Cl

mAU

60

mAU
20

O
N

50

250

40

200

O

N

(S)

30

150

20

100

10

50

(R)

10

0

0.0

: CHIRAL ART Cellulose-C
5 μm, 250 X 4.6 mmI.D.
Eluent: n-hexane/2-propanol/formic acid/DEA*1(70/30/0.1/0.1)
Flow rate: 1.0 mL/min
Temperature : 25°C
Detection: UV at 230 nm
Injection: 2 μL (0.2 mg/mL)

Column5

1015

Column

CH3

CH3
O

CH3

OH

H3C

CH3

(3R, 3’S), (3S, 3’R)

(3S, 3’S)(3R, 3’R)

U151119D2

H170712D

20 min

0

HO

H3C

CH3

CH3

CH3

0

0

F141211A

O
H3C

OH

2.5

5.0

12.5

10.0

7.5

min

0.0

: CHIRAL ART Cellulose-SJ
5 μm, 250 X 4.6 mmI.D.
Eluent: n-hexane/ethanol/diethylamine(95/5/0.1)
Flow rate: 1.0 mL/min
Temperature : 25°C
Detection: UV at 270 nm
Injection: 5 μL (1 mg/mL)

5.0

10.0

15.0

20.0

25.0

30.0

35.0

min

Column: CHIRAL ART Cellulose-SC
5 μm, 250 X 4.6 mmI.D.
Eluent: n-hexane/THF (80/20)
Flow rate: 1.0 mL/min
Temperature : 25°C
Detection: VIS at 476 nm
Injection: 5 μL (0.5 mg/mL)*2Courtesy of Fuji Chemical Industry Co., Ltd.

*1diethylamine

Excellent peak shape(R)

Column: 5 μm, 250 X 4.6 mmI.D.
Eluent: n-hexane/2-propanol/diethylamine (80/20/0.1)
Flow rate: 1.0 mL/min
Temperature : 25°C
Detection: 230 nmInjection: 10 μL (0.1 mg/mL)

(S)
(S)

(R)
Propranolol

V130614G3

V140131A3

0

2

4

6

8

10

12

14

min

Chiral Separation Columns and Packing Materials

CHIRAL ART are suitable for separation of a wide range of compounds.

CHIRAL ART provide good peak shapes on ionic and metal coordination compounds.

Low column bleeding
mAU
500

mAU
500

450

450

1st run

350

350

5th run

300
250

250
200

150

150

100

100

50

50

0
-20

0
-20

0

5

10

15

20

25

5th run

300

200

min

Gradient test
Column: 5 μm, 250 X 4.6 mmI.D.
Eluent: A) n-hexaneB) ethanol
2-80%B (0-30 min)Flow rate: 1.0 mL/min
Temperature : 25°C
Detection: UV at 230 nm

1st run

400

400

0

5

10

15

20

25

min

CHIRAL ART immobilized type show remarkably reduced background signal under the typical gradient conditions. CHIRAL ART immobilized type offer excellent
robustness on gradient analysis and highly sensitive analysis on LC/MS due to the very low ion suppression as well as a stable baseline.

63

06

Chiral Separation Columns and Packing Materials% of initial value

Extended packing durability
120

Sequential gradient test

Column performance test

100

ColumnEluentColumn: 5 μm, 250 X 4.6 mmI.D.
Eluent: n-hexane/ethanol (90/10)
Flow rate: 1.0 mL/min
Temperature : 37°C
Detection: UV at 230 nm
Sample: trans-Stilbene oxide: 5 μm, 250 X 4.6 mmI.D.
: A) n-hexane, B) ethanol
0-100%B (0-15 min)Flow rate: 3.0 mL/min
Pressure: 10-30 MPa/run
Temperature : 37°C

80
60

CHIRAL ART have outstanding packed bed stability provided by using highstrength super wide pore silica and innovative packing technology. The column
efficiency and selectivity are maintained even after the sequential gradient tests
at a high flow rate (three times higher than normal flow rate) and under highpressure (rapid pressure change). CHIRAL ART are useful for shortening analysis
time, (re-)equilibration time, or/and column cleaning time by increasing the flow
rate. CHIRAL ART are also effective when using highly viscose solvents as amobile phase on immobilized type columns.

40

Theoretical plate number
Separation factor (α)

20
0

0

20

40

60

80

100

120

run

Wide usable pH range (Immobilized type)
Column performance test

Continuous flow of acidic/
alkaline solution

ColumnEluentFlow rate

ColumnEluentColumn performance test

[Acidic condition]
Buffer
: 0.1% H3PO4 (pH 2)
Temperature : 40°C

: 5 μm, 50 X 4.6 mmI.D.
: Buffer/methanol (90/10): 1.0 mL/min: 5 μm, 50 X 4.6 mmI.D.
: methanol/water (70/30) for Cellulose-SJ
acetonitrile/water (30/70) for Cellulose-SB
Flow rate: 1.0 mL/min
Temperature : 25°C
Detection: UV at 254 nm
Sample: 1-(1-Naphthyl)ethanol for Cellulose-SJ
Benzoin for Cellulose-SB[Alkaline condition]
Buffer: 20 mM NH4HCO3-DEA*2 (pH 9)
Temperature : 25°C

*1CV=Column Volume% of initial theoretical plate number*2diethylamine% of initial theoretical plate number

Chiral Separation Columns and Packing Materials

Continuous flow of acidic/alkaline solution

pH 2, 40℃
100

80

Cellulose-SJ
Cellulose-SB

60

0

1000

2000

3000

CHIRAL ART immobilized typehave excellent chemical stability
and can be used across a wide pH
range. CHIRAL ART also enable therobust analysis of ionic compounds
requiring pH control of mobile phasein reversed-phase conditions.

pH 9, 25℃
100

80

Cellulose-SJ
Cellulose-SB

60

0

1000

Volume of solution flushed (CV)

2000

3000

Volume of solution flushed (CV)High solvent versatility (Immobilized type)

Initial

Initial

Initialα = 1.19k’(2) = 6.60

α = 1.39k’(2) = 4.20

SA20_B001

01

H170703A008

SB01_01B2

After flushing with1,000 CV ofethyl acetate
SA20_B10

α = 1.26k’(2) = 7.33

After flushing with1,000 CV oftetrahydrofuran

α = 1.20k’(2) = 6.68
23

α = 1.38
k’(2) = 4.12

SB01_10B2

4

5

6

7

min

0

After flushing with1,000 CV ofdichloromethane1

α = 1.25k’(2) = 7.21

H170703L008

2

3

4

min

Retention rate of initial column performance (After flushing with 1,000 CV of each solvent at 40℃)
Amylose-SA
α

64

0

1

*CV=Column Volume

Cellulose-SJ

Cellulose-SB

2

k’(2)

α

k’(2)

α

k’(2)

Ethyl acetate

100.3%

101.2%

100.0%

99.1%

99.3%

99.0%

Tetrahydrofuran

100.0%

100.0%

99.3%

98.0%

99.2%

99.7%

Dichloromethane

100.3%

100.6%

101.3%

99.6%

99.6%

98.4%

3

4

5

6

7

min

CHIRAL ART immobilized
type have high solvent
versatility. After flushingwith various solvents, thelosses of initial column
performances were lessthan 2%.

Method scouting
Method scouting is effective for method development of chiral compound separation. Rapid method development can be achieved by studying combination ofmobile phases and columns comprehensively, and then optimizing a candidate condition.

n-hexane

Eluent A
2-propanol

Eluent B

ethanol

Amylose-C
Neo

0.1% diethylamine
mAU
150

150

100

100

50

50

150
150

0.0

2.5

5.0

7.5

min

150
100

100

0
0.0

2.5

5.0

7.5

min

2.5

5.0

7.5

0
0.0

2.5

5.0

7.5

150

50

0

0
0.0

2.5

5.0

7.5

min

75
50

50

50

25

0

0
5.0

40
35
30
25
20
15
10
5
0
0.0

7.5

min

Rs=3.32
1.0

2.0

3.0

4.0

5.0

6.0

7.0

8.0

2.5

5.0

7.5

min

Rs=3.62

55
50
45
40
35
30
25
20
15
10
5
0
0.0

1.0

2.0

3.0

4.0

5.0

6.0

7.0

8.0

9.0 min

150

150

100

100

1.0

2.0

3.0

4.0

5.0

6.0

7.0

8.0

9.0 min

200

0.0

7.5

min

0.0

2.5

5.0

7.5

min

0.0

2.5

5.0

7.5

min

50

2.5

5.0

7.5

0
0.0

min

2.5

5.0

7.5

min

150

100

100

50

50

0
0.0

2.5

5.0

7.5

0
0.0

min

2.5

5.0

7.5

min

30

30
25

25

20

30

20

25

15

15

20

10

10

5

5

0

0

0.0

1.0

2.0

3.0

4.0

5.0

6.0

7.0

8.0

9.0 min

0.0

15
10
5
0
1.0

2.0

1.0

2.0

3.0

4.0

5.0

6.0

7.0

8.0

9.0 min

3.0

4.0

5.0

6.0

7.0

8.0

ColumnFlow rate
Gradient

1.0

2.0

3.0

4.0

5.0

6.0

7.0

8.0

9.0 min

150
125

150

5.0

150

0

0

2.5

100

50

50

0.0

9.0 min

0.0

1.0

2.0

3.0

4.0

5.0

6.0

100

50
50

25

0.0

Phenoxybenzamine

0

0
1.0

2.0

3.0

4.0

5.0

6.0

7.0

8.0

9.0 min

0.0

8.0: 3 μm, 75 X 3.0 mmI.D.
: 0.425 mL/min: 5-45%B (0-6 min),
45%B (6-10 min)

75

100

7.0

*1 methyl tert-butyl ether

200

200

min

0

0
0.0

9.0 min

7.5

50

100

150

2.5

5.0

150

0.0

100

0.0

2.5

100

200

100

0.0

200

100

50

min

0

min

150

100

50

0
0.0

200
100

100

50

50

0

0

0.0

Cellulose-C

ethyl acetate

1mAU

The result of screening
using columns for chiral separation

Rs=6.0150
40

9.0 minChiral Separation Columns and Packing Materials

Cellulose-SJ Cellulose-SC Cellulose-SB

Amylose-SA

Additive

ColumnMTBE *

THF

Success rate ; about 90% (Number of studies ; 520)

30
20
10

H170720D

0
0.0

2.5

5.0

7.5

10.0

12.5

Success rate of each columns

min

Column: CHIRAL ART Cellulose-SJ
5 μm, 250 X 4.6 mmI.D.
Eluent: n-hexane/ethanol/diethylamine (95/5/0.1)
Flow rate: 1.0 mL/min
Temperature : 25°C
Detection: UV at 270 nm
Injection: 5 µL (1.0 mg/mL)

Amylose-C Neo

Based on the result of method scouting, the elution mode waschanged to isocratic and the particle size and the column size were
optimized.

65

06

Chiral Separation Columns and Packing Materials
High purity preparative purification of chiral compound using recycling HPLC
Recycling preparative chromatogram of flurbiprofen (loading 560 mg)

tR1
tR2

ColumnChiral Separation Columns and Packing Materials
66

EluentFlow rate
Detection
Injection: CHIRAL ART Cellulose-C
5 μm, 250 X 30 mmI.D.
: n-hexane/2-propanol/TFA (95/5/0.1): 45 mL/min: UV at 280 nm: 560 mg＊

Flurbiprofen

Single column
Enantiomeric purity (%ee)
Yield (%)
Productivity (mg product/hr)
Solvent consumption (L/g-product)

Recycling

tR1

tR2

tR1

tR2

>99

>97

>99

99

87

74

89

90

122

103

335

336

Productivity : about 3 times higher

22

26

2.0

2.0

Solvent consumption : about 1/10

Productivity of single column preparation is estimated based on the stacking injection of the sample every 2.5 minutes

Above is the result of preparative separation of chiral compound, flurbiprofen. Recycling preparation can achieve high purity and high yield on purification of thecompound which is difficult to optimize preparative separation conditions using a single column method. Recycling preparation greatly contributes to reductionof solvent consumption and costs on purification as mobile phase is circulated during recycling mode.

Synthesized macromolecule-type

YMC CHIRAL NEA (R), (S)Synthesized macromolecule-type chiral column
Elution order can be reversed by selection (R) or (S)Can be used in both normal-phase and reversed-phaseAvailable for bulk scale

Particle size : 5 μm
Pore size : 300 ÅUsable pH range : 2-6.5

Chiral polymer-bonded silica gel for chiral separation
YMC CHIRAL NEA (R) and (S) are chiral polymer-bonded silica gel for chiral separation. Chiral discrimination is based on the higherorder structure of chiral macromolecules, which includes hydrogen bonding, π-π interaction, hydrophobic interaction, etc.
YMC CHIRAL NEA (R) and (S) have excellent durability and cost performance.

For separation of chiral compounds
KetamineO＊ NHCH3

CI

0

10

20

: YMC CHIRAL NEA (R)250 X 4.6 mmI.D.
Eluent: acetonitrile/0.5 M NaCIO4 (40/60)
Flow rate: 1.0 mL/min
Temperature : ambient
Detection: UV at 268 nm

min

2,2,2-Trifluoro-1- (9-anthryl) ethanol

(S)
(R)

CF3
＊ CHOH

Column: YMC CHIRAL NEA (R)250 X 4.6 mmI.D.
Eluent: acetonitrile/water (40/60)
Flow rate: 1.0 mL/min
Temperature : 30°C
Detection: UV at 254 nm

N050823B-3

0

10

20

30

min

Chiral Separation Columns and Packing Materials

ColumnCyclodextrin-type

YMC CHIRAL CD BR
Cyclodextrin type chiral separation column
Useful for separation of optical isomers and structural isomers
Three cavity types, α, β and γ, are available

Particle size : 5 μm
Pore size : 120 ÅUsable pH range : 3.5-6.5

Chiral separation column utilizing host-guest interaction
YMC CHIRAL CD BR are composed of 3 types of chiral separation columns. Each column possesses α-, β- or γ-bromo-cyclodextrin
as a bonded phase. Selection from the 3 types of columns enables analysis of a wide range of compounds. In addition, YMC CHIRAL
CD BR show different selectivity from ODS because the separation is based on host-guest interaction. YMC CHIRAL CD BR are
useful for separating structural isomers that are difficult to separate on ODS.

Three types; α, β and γ-CD BR are available

α

β

γ

67

06

Chiral Separation Columns and Packing Materials
Ordering Information –Columns–
CHIRAL ART

Chiral Separation Columns and Packing Materials

Particle
Column size
Immobilized type
Coated typesize inner diameter X
Amylose-SA
Cellulose-SB
Cellulose-SC
Cellulose-SJ
Amylose-C Neo
Cellulose-C(μm)
length (mm)2.0 X 75
KSA99S03-L502WT KSB99S03-L502WT KSC99S03-L502WT KSJ99S03-L502WT KBN99S03-L502WT KCN99S03-L502WT
2.0 X 100
KSA99S03-1002WT KSB99S03-1002WT KSC99S03-1002WT KSJ99S03-1002WT KBN99S03-1002WT KCN99S03-1002WT
2.0 X 150
KSA99S03-1502WT KSB99S03-1502WT KSC99S03-1502WT KSJ99S03-1502WT KBN99S03-1502WT KCN99S03-1502WT
2.0 X 250
KSA99S03-2502WT KSB99S03-2502WT KSC99S03-2502WT KSJ99S03-2502WT KBN99S03-2502WT KCN99S03-2502WT
3.0 X 50
KSA99S03-0503WT KSB99S03-0503WT KSC99S03-0503WT KSJ99S03-0503WT KBN99S03-0503WT KCN99S03-0503WT
3.0 X 75
KSA99S03-L503WT KSB99S03-L503WT KSC99S03-L503WT KSJ99S03-L503WT KBN99S03-L503WT KCN99S03-L503WT
3.0 X 100
KSA99S03-1003WT KSB99S03-1003WT KSC99S03-1003WT KSJ99S03-1003WT KBN99S03-1003WT KCN99S03-1003WT
3
3.0 X 150
KSA99S03-1503WT KSB99S03-1503WT KSC99S03-1503WT KSJ99S03-1503WT KBN99S03-1503WT KCN99S03-1503WT
3.0 X 250
KSA99S03-2503WT KSB99S03-2503WT KSC99S03-2503WT KSJ99S03-2503WT KBN99S03-2503WT KCN99S03-2503WT
4.6 X 50
KSA99S03-0546WT KSB99S03-0546WT KSC99S03-0546WT KSJ99S03-0546WT KBN99S03-0546WT KCN99S03-0546WT
4.6 X 75
KSA99S03-L546WT KSB99S03-L546WT KSC99S03-L546WT KSJ99S03-L546WT KBN99S03-L546WT KCN99S03-L546WT
4.6 X 100
KSA99S03-1046WT KSB99S03-1046WT KSC99S03-1046WT KSJ99S03-1046WT KBN99S03-1046WT KCN99S03-1046WT
4.6 X 150
KSA99S03-1546WT KSB99S03-1546WT KSC99S03-1546WT KSJ99S03-1546WT KBN99S03-1546WT KCN99S03-1546WT
4.6 X 250
KSA99S03-2546WT KSB99S03-2546WT KSC99S03-2546WT KSJ99S03-2546WT KBN99S03-2546WT KCN99S03-2546WT
4.6 X 150
KSA99S05-1546WT KSB99S05-1546WT KSC99S05-1546WT KSJ99S05-1546WT KBN99S05-1546WT KCN99S05-1546WT
4.6 X 250
KSA99S05-2546WT KSB99S05-2546WT KSC99S05-2546WT KSJ99S05-2546WT KBN99S05-2546WT KCN99S05-2546WT
5
10 X 250
KSA99S05-2510WT KSB99S05-2510WT KSC99S05-2510WT KSJ99S05-2510WT KBN99S05-2510WT KCN99S05-2510WT
20 X 250
KSA99S05-2520WX KSB99S05-2520WX KSC99S05-2520WX KSJ99S05-2520WX KBN99S05-2520WX KCN99S05-2520WX
30 X 250
KSA99S05-2530WX KSB99S05-2530WX KSC99S05-2530WX KSJ99S05-2530WX KBN99S05-2530WX KCN99S05-2530WXCHIRAL ART Guard cartridges
Particle
Column size
Immobilized type
Coated typesize inner diameter X
Amylose-SA
Cellulose-SB
Cellulose-SC
Cellulose-SJ
Amylose-C Neo
Cellulose-C(µm)
length (mm)2.1 X 10
KSA99S03-01Q1GC KSB99S03-01Q1GC KSC99S03-01Q1GC KSJ99S03-01Q1GC KBN99S03-01Q1GC KCN99S03-01Q1GC
3.0 X 10
KSA99S03-0103GC KSB99S03-0103GC KSC99S03-0103GC KSJ99S03-0103GC KBN99S03-0103GC KCN99S03-0103GC
3
4.0 X 10
KSA99S03-0104GC KSB99S03-0104GC KSC99S03-0104GC KSJ99S03-0104GC KBN99S03-0104GC KCN99S03-0104GC
4.0 X 10
KSA99S05-0104GC KSB99S05-0104GC KSC99S05-0104GC KSJ99S05-0104GC KBN99S05-0104GC KCN99S05-0104GC
5
10 X 10
KSA99S05-0110CC KSB99S05-0110CC KSC99S05-0110CC KSJ99S05-0110CC KBN99S05-0110CC KCN99S05-0110CC*Guard cartridge holder required, part no. XPGCH-Q1 for 2.1-4.0 mmI.D. and XPCHSPW1 for 10 mmI.D.

Alcyon SFC CSP
Particle
Column size
Immobilized type
Coated typesize inner diameter X
Amylose-SA
Cellulose-SB
Cellulose-SC
Cellulose-SJ
Amylose-C Neo
Cellulose-C(μm)
length (mm)
KSA99S03-15Q1WTS KSB99S03-15Q1WTS KSC99S03-15Q1WTS KSJ99S03-15Q1WTS KBN99S03-15Q1WTS KCN99S03-15Q1WTS
2.1 X 150
3.0 X 50
KSA99S03-0503WTS KSB99S03-0503WTS KSC99S03-0503WTS KSJ99S03-0503WTS KBN99S03-0503WTS KCN99S03-0503WTS
3.0 X 100
KSA99S03-1003WTS KSB99S03-1003WTS KSC99S03-1003WTS KSJ99S03-1003WTS KBN99S03-1003WTS KCN99S03-1003WTS
3
3.0 X 150
KSA99S03-1503WTS KSB99S03-1503WTS KSC99S03-1503WTS KSJ99S03-1503WTS KBN99S03-1503WTS KCN99S03-1503WTS
4.6 X 150
KSA99S03-1546WTS KSB99S03-1546WTS KSC99S03-1546WTS KSJ99S03-1546WTS KBN99S03-1546WTS KCN99S03-1546WTS
4.6 X 250
KSA99S03-2546WTS KSB99S03-2546WTS KSC99S03-2546WTS KSJ99S03-2546WTS KBN99S03-2546WTS KCN99S03-2546WTS
2.1 X 150
KSA99S05-15Q1WTS KSB99S05-15Q1WTS KSC99S05-15Q1WTS KSJ99S05-15Q1WTS KBN99S05-15Q1WTS KCN99S05-15Q1WTS
4.6 X 150
KSA99S05-1546WTS KSB99S05-1546WTS KSC99S05-1546WTS KSJ99S05-1546WTS KBN99S05-1546WTS KCN99S05-1546WTS
5
4.6 X 250
KSA99S05-2546WTS KSB99S05-2546WTS KSC99S05-2546WTS KSJ99S05-2546WTS KBN99S05-2546WTS KCN99S05-2546WTS
10 X 250
KSA99S05-2510WTS KSB99S05-2510WTS KSC99S05-2510WTS KSJ99S05-2510WTS KBN99S05-2510WTS KCN99S05-2510WTS
20 X 250
KSA99S05-2520WTS KSB99S05-2520WTS KSC99S05-2520WTS KSJ99S05-2520WTS KBN99S05-2520WTS KCN99S05-2520WTS＊See pp.120-121 for details of Alcyon SFC CSP

Ordering Information –Packing Materials–
CHIRAL ART
Particle
size
(μm)
5
10
20

Immobilized type
Amylose-SA
KSA99S05
KSA99S11
KSA99S21*Inquire us for the Amylose-C

68

Cellulose-SB
KSB99S05
KSB99S11
KSB99S21

Cellulose-SC
KSC99S05
KSC99S11
KSC99S21

Coated type
Cellulose-SJ
KSJ99S05
KSJ99S11
KSJ99S21

Amylose-C Neo
KBN99S05
KBN99S11
KBN99S21

Cellulose-C
KCN99S05
KCN99S11
KCN99S21

Ordering Information –Columns–
YMC CHIRAL NEA(R)(S) : Reversed-phasePhase
dimension
NEA(R)300 Å
5 μm
NEA(S)300 Å
5 μm

Column I.D.
(mm)

Column length (mm)Guard cartridges

150

250

I.D. (mm)

10 mm length

4.6

NR30S05-1546WTNR30S05-2546WT

4.0

NR30S05-0104GC

4.6

NS30S05-1546WTNS30S05-2546WT

4.0

NS30S05-0104GCYMC CHIRAL NEA(R)(S) : Normal-phasePhase
dimension

Column length (mm)Guard cartridges

150

250

I.D. (mm)

10 mm length

4.6

CR30S05-1546WTCR30S05-2546WT

4.0

CR30S05-0104GC

4.6

CS30S05-1546WTCS30S05-2546WT

4.0

CS30S05-0104GCYMC CHIRAL CD BR
Phase
dimension
α-CD BR120 Å
5 μm
β-CD BR120 Å
5 μm
γ-CD BR120 Å
5 μm

Column I.D.
(mm)

Column length (mm)Guard cartridges

150

250

I.D. (mm)

10 mm length

4.6

DA12S05-1546WTDA12S05-2546WT

4.0

DA12S05-0104GC

4.6

DB12S05-1546WT

DB12S05-2546WT

4.0

DB12S05-0104GC

4.6

DG12S05-1546WTDG12S05-2546WT

4.0

DG12S05-0104GC*Guard cartridge holder required, part no. XPGCH-Q1.

Chiral Separation Columns and Packing Materials

NEA(R)300 Å
5 μm
NEA(S)300 Å
5 μm

Column I.D.
(mm)

69