Link to Research Activity
Name: Hidekazu Arai, Ph.D.
Birth: May, 1971
Affiliation: Laboratory of Clinical Nutrition and Management, Graduate Division of Nutritional andEnvironmental Sciences, the University of Shizuoka
Education:
1995 Graduated from School of Nutrition, Faculty of Medicine, University of Tokushima.
1997 Completed Master Program of Nutrition, Graduate School of Nutrition, University of Tokushima.
2000 Completed Doctoral Program of Nutrition, Graduate School of Nutrition, University of Tokushima,
under supervision of Prof. Eiji Takeda, Doctor of Nutrition (Ph.D)
Faculty Appointments:
2000: Research Assistant Professor, Department of Clinical Nutrition, University of Tokushima
2004: Research Assistant Professor, Department of Clinical Nutrition, Institute of Health Biosciences,
University of Tokushima Graduate School
2007: Associate Professor, Chief, Laboratory of Clinical Nutrition and Management, Department ofNutrition, School of Food and Nutritional Sciences, and Graduate School of Nutritional and Environmental
Sciences, The University of Shizuoka
2012: Associate Professor, Chief, Laboratory of Clinical Nutrition and Management, Graduate Division ofNutritional and Environmental Sciences, The University of Shizuoka
2018-present: Professor, Chief, Laboratory of Clinical Nutrition and Management, Graduate Division ofNutritional and Environmental Sciences, The University of Shizuoka
Membership in Academic Societies:
Japan Society of Nutrition and Food Science
Japan Society of Metabolism and Clinical Nutrition
Japanese Society of Nutrition and Dietetics
Japanese Society of Clinical Nutrition
Japanese Society on Nutrition Care and Management
Japan Atherosclerosis Society
Japanese Society of Gout and Uric & Nucleic Acids
Japanese Association of Nutritional Science Education
Japan Dietetic Association

Publications (articles in peer-reviewed journals)

59) Koike R, Kawakami Y, Kondo R, Onishi M, Akiyama M, Asai T, Arai H. Effect of dietary
therapy on patients with asymptomatic hyperuricemia. J Med Invest. 70(1-2): 34-40. (2023)
58) Sato M, Kawakami Y, Arai H. Purine content and renal acid load evaluation in healthy
Japanese diets. J Nutr Sci Vitaminol., 69(1):7-13 (2023)
57) Okamoto H, Kawakami Y, Kaneko M, Ishida E. Sato M, Matsukawa H, Hosaka T, Arai H.
The urinary excretion of magnesium as an effective magnesium deficiency state indicator: acontrolled intervention trial. J Nutr Sci Vitaminol., 69(1):21-27 (2023)
56) Kawakami Y, Mazuka M, Yasuda A, Sato M, Hosaka T, Arai H. Acute effect of fructose,sucrose, and isomaltulose on uric acid metabolism in healthy participants. J Clin Biochem
Nutr.72(1):61-67 (2023)
55) Kawakami Y, Yasuda A, Hayashi M, Akiyama M, Asai T, Hosaka T, Arai H. Acute effectof green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men. Clin
Rheumatol., 40(7):2881-2888 (2021)
54) Kawakami Y, Watanabe Y, Mazuka M, Yagi N, Sawazaki A, Koganei M, Natsume M, Kuriki
K, Morimoto T, Asai T, Arai H. Effect of cacao polyphenol-rich chocolate on postprandial
glycemia, insulin, and incretin secretion in healthy participants. Nutrition., 85:111128 (2021)
53) Saito Y, Sakuma M, Narishima Y, Yoshida T, Kumagai H, Arai H. Greater consumption ofnoodle is associated with higher serum phosphorus levels: a cross-sectional study on healthy
participants. J Clin Biochem Nutr., 68(1):78-85 (2021)
52) Sato M, Morishita T, Katayama T, Satomura S, Okuno H, Sumida N, Sakuma M, Arai H,Katoh S, Sairyo K, Kawaura A, Takeda E. Relationship between age-related decreases inserum 25-hydroxyvitamin D levels and skeletal muscle mass in Japanese women. J MedInvest., 67(1.2):151-157 (2020)
51) Kawamoto K, Sakuma M, Tanaka S, Masuda M, Nakao-Muraoka M, Niida Y, Nakamatsu
Y, Ito M, Taketani Y, Arai H.: High-fat diets provoke phosphorus absorption from the small
intestine in rats. Nutrition., 72:110694 (2020)
50) Aoyama T, Yoshitsugu K, Fukaya M, Kume T, Kawashima M, Nakajima K, Arai H, ImatakiO, Enami T, Tatara R, Ikeda T.: Benefit of Reducing Body Weight Loss with A Nutritional
Support Pathway in Patients Undergoing Allogeneic Hematopoietic Stem Cell
Transplantation. Med Sci Monit Basic Res., 25:187-198 (2019)49) Kosugi R, Nakatani E, Okamoto K, Aoshima S, Arai H, InoueT.: Effects of Sodium-glucose
cotransporter 2 inhibitor (dapagliflozin) on food intake and plasma fibroblast growth factor
21 levels in type 2 diabetes patients. Endocr J., 66(8):677-682 (2019)48) Saito Y, Sakuma M, Narishima Y, Yoshida T, Kumagai H, Arai H.: Habitual confectionery
intake is associated with serum phosphorus levels: A cross-sectional study on healthy
subjects. J Med Invest., 66(1.2):134-140 (2019)47) Yamanaka M, Sakuma M, Matsushita A, Tanaka S, Yamamoto Y, Asai T, Arai H.: Theeffects of long-term dietary therapy on patients with hypertriglyceridemia. J Atheroscler

Thromb., 26(1):39-49 (2019)46) Hashidume T, Sasaki K, Hirata J, Kato M, Yoshikawa Y, Iwasaki Y, Arai H, Miura S,
Miyoshi N.: Effects of Sanyaku and Its Constituent Diosgenin on the Fasted and Postprandial
Hypertriacylglycerolemia in High-Fat-Diet-Fed KK- Ay Mice. J Agric Food Chem., 66(38):9968-9975 (2018)45) Sakuma M, Suzuki A, Kikuchi M, Arai H.: Soymilk intake has desirable effects onphosphorus and calcium metabolism. J Clin Biochem Nutr., 62(3):259-263 (2018)44) Morishita T, Sato M, Kume H, Sakuma M, Arai H, Katayama T, Katoh S, Sairyo K, Takeda
E.: Skeletal muscle mass of old Japanese women suffering from walking difficulty in nursing
home. J Med Invest., 65(1.2):122-130 (2018)43) Aoyama T, Imataki O, Arai H, Kume T, Shiozaki H, Katsumata N, Mori M, Ishide K, Ikeda
T.: Comparison of Nutrition-Related Adverse Events and Clinical Outcomes Between ICE(Ifosfamide, Carboplatin, and Etoposide) and MCEC (Ranimustine, Carboplatin, Etoposide,and Cyclophosphamide) Therapies as Pretreatment for Autologous Peripheral Blood Stem
Cell Transplantation in Patients with Malignant Lymphoma. Med Sci Monit Basic Res.,
24:31-39 (2018)42) Yoshikawa R, Yamamoto H, Nakahashi O, Kagawa T, Tajiri M, Nakao M, Fukuda S, AraiH, Masuda M, Iwano M, Takeda E, Taketani Y.: The age-related changes of dietary phosphate
responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1
gene expression is associated with renal α-Klotho gene expression in mice. J Clin Biochem
Nutr., 62(1):68-74 (2018)41) Aoyama T, Arai H, Imataki O, Ikeda T.: Factors Influencing Loss of Body Weight in Cord
Blood Transplantation with Nutritional Support for Hematopoietic Stem Cell Transplantation.
Asian J Clin Nutr., 9(3) 137-146. (2017)40) Sakuma M, Morimoto Y, Suzuki Y, Suzuki A, Noda S, Nishino K, Ando S, Ishikawa M
Arai H. Availability of 24-h urine collection method on dietary phosphorus intake estimation.
J Clin Biochem Nutr., 60(2) 125-129. (2017)39) Ohta H, Sakuma M, Suzuki A, Morimoto Y, Ishikawa M, Umeda M, Arai H. Effects ofgender and body weight on fibroblast growth factor 23 responsiveness to estimated dietaryphosphorus. J Med Invest., 63(1-2) 58-62. (2016)38) Sakuma M, Noda S, Morimoto Y, Suzuki A, Nishino K, Ando S, Umeda M, Ishikawa M,Arai H.: Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized
crossover trial. Nutr J., 14:106. (2015)37) Ando S, Sakuma M, Morimoto Y, Arai H.: The Effect of Various Boiling Conditions onReduction of Phosphorus and Protein in Meat. J Ren Nutr., 25(6) 504-509, (2015)36) Morimoto Y, Sakuma M, Ohta H, Suzuki A, Matsushita A, Umeda M, Ishikawa M, Taketani
Y, Takeda E, Arai H. Estimate of dietary phosphorus intake using 24 hour urine collection.
J Clin Biochem Nutr., 55(1) 62-66. (2014)35) Ohnishi T, Hisaoka F, Morishima M, Takahashi A, Harada N, Mawatari K, Arai H,

Yoshioka E, Toda S, Izumi K, and Nakaya Y. Establishment of a Model of SpontaneouslyRunning-Tokushima-Shikoku Rats with Left Atrial Thrombosis. J Toxicol Pathol., 27: 51-56.
(2014)
34) Ohminami H, Amo K, Taketani Y, Sato K, Fukaya M, Uebanso T, Arai H, Koganei M,Sasaki H, Yamanaka-Okumura H, Yamamoto H, Takeda E. Dietary combination of sucrose
and linoleic acid causes skeletal muscle metabolic abnormalities in Zucker fatty rats throughspecific modification of fatty acid composition. J Clin Biochem Nutr., 55(1), 15-25 (2014).
33) Sakuma M, Sasaki M, Katsuda S, Kobayashi K, Takaya C, Umeda M, Arai H. Assessmentof metabolic status in young Japanese females using postprandial glucose and insulin levels.
J Clin Biochem Nutr., 54(3): 204-209. (2014)32) Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, Takei Y, Masuda M,
Yamanaka-Okumura H, Takeda E. Liver X receptor negatively regulates fibroblast growth
factor 21 in the fatty liver induced by cholesterol-enriched diet. J Nutr Biochem., 23(7):78590. (2012)31) Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M,Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E. Paradoxical Regulation of Human
FGF21 by Both Fasting and Feeding Signals: Is FGF21 a Nutritional Adaptation Factor?
PLoS One., 6(8):e22976. (2011)30) Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y,Takeda E. Effects of xylitol on metabolic parameters and visceral fat accumulation. J Clin
Biochem Nutr., 49(1):1-7. (2011)29) Ishiguro M, Yamamoto H, Masuda M, Kozai M, Takei Y, Sato T, Segawa H, Taketani Y,Arai H, Miyamoto KI, Takeda E. Thyroid hormones regulate phosphate homeostasis throughtranscriptional control of the renal type IIa sodium-dependent phosphate co-transporter(Npt2a) gene. Biochem J., 427(1):161-169. (2010)28) Arai H, Awane N, Mizuno A, Fukaya M, Sakuma M, Harada N, Kawaura A, Yamamoto H,Okumura H, Taketani Y, Doi T and Takeda E. Increasing early insulin secretion compensate
adequately for hepatic insulin resistance in CCl4-induced cirrhosis rats. J Med Invest., 57(12):54-61. (2010)27) Egi M, Toda Y, Katayama H, Yokoyama M, Morita K, Arai H, Yamatsuji T, Bailey M,Naomoto Y. Safer glycemic control using isomaltulose-based enteral formula: A pilot
randomized crossover trial. J Crit Care., 25(1):90-96. (2010)26) Sakuma M, Arai H, Mizuno A, Fukaya M, Matsuura M, Sasaki H, Yamanaka-Okumura H,Yamamoto H, Taketani Y, Doi T, Takeda E. Improvement of glucose metabolism in patientswith impaired glucose tolerance or diabetes by long-term administration of a palatinosebased liquid formula as a part of breakfast. J Clin Biochem Nutr., 45(2):155-162. (2009)25) Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Amo K, Harada N,
Arai H, Yamamoto H, Takeda E. Hypocaloric high protein diet improves fatty liver andhypertriglyceridemia in sucrose-fed obese rats via two pathways. Am J Physiol Endocrinol

Metab.; 297(1):E76-84. (2009)24) Yoshida M, Harada N, Yamamoto H, Taketani Y, Nakagawa T, Yin Y, Hattori A, Zenitani T,Hara S, Yonemoto H, Nakamura A, Nakano M, Mawatari K, Teshigawara K, Arai H, HosakaT, Takahashi A, Yoshimoto K, Nakaya Y. Identification of cis-acting promoter sequences
required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice. Biochim
Biophys Acta., 1791(1):39-52. (2009)23) Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T,
Yamamoto H, Taketani Y, Takeda E. Palatinose and oleic acid act together to prevent
pancreatic islet disruption in nondiabetic obese Zucker rats. J Med Invest., 55(3-4):183-95.
(2008)
22) Uebanso T, Arai H, Taketani Y, Fukaya M, Yamamoto H, Mizuno A, Uryu K, Hada T,Takeda E. Extracts of momordica charantia suppress postprandial hyperglycemia in rats. J
Nutr Sci Vitaminol., 53(12)482-488. (2007)21) Sato K, Arai H, Mizuno A, Fukaya M, Sato T, Koganei M, Sasaki H, Yamamoto H, Taketani
Y, Doi T, Takeda E. Dietary Palatinose and Oleic Acid Ameliorate Disorders of Glucose andLipid Metabolism in Zucker Fatty Rats. J Nutr., 137(8):1908-1915. (2007)
20) Fukaya M, Mizuno A, Arai H, Muto K, Uebanso T, Matsuo K, Yamamoto H, Taketani Y,Doi T, Takeda E. Mechanism of rapid-phase insulin response to elevation of portal glucoseconcentration. Am J Physiol Endocrinol Metab., 293(2):E515-522 (2007)19) Sawada N, Taketani Y, Amizuka N, Ichikawa M, Ogawa C, Nomoto K, Nashiki K, Sato T,Arai H, Isshiki M, Segawa H, Yamamoto H, Miyamoto K, Takeda E. Caveolin-1 in
extracellular matrix vesicles secreted from osteoblasts. Bone, 41(1):52-58. (2007)18) Mizuno A, Arai H, Fukaya M, Sato M, Yamanaka-Okumura H, Takeda E, Doi T. Earlyphase insulin secretion is disturbed in obese subjects with glucose intolerance. Metabolism,
56(6):856-862. (2007)17) Tani Y, Sato T, Yamanaka-Okumura H, Yamamoto H, Arai H, Sawada N, Genjida K,Taketani Y, Takeda E. Effects of Prolonged High Phosphorus Diet on Phosphorus andCalcium Balance in Rats. J Clin Biochem Nutr., 40(3):221-228. (2007)16) Matsuo K, Arai H, Muto K, Fukaya M, Sato T, Mizuno A, Sakuma M, Yamanaka-Okumura
H, Sasaki H, Yamamoto H, Taketani Y, Doi T, TakedaE. The anti-obesity effect of thepalatinose-based formula Inslow is likely due to an increase in the hepatic PPAR-α andadipocyte PPAR-γ gene expressions. J Clin Biochem Nutr., 40(3):234-241. (2007)
15) Arai H, Mizuno A, Sakuma M, Fukaya M, Matsuo K, Muto K, Sasaki H, Matsuura M,Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E. Effects of a palatinose-based liquid
diet (Inslow) on glycemic control and the second meal effect in healthy men. Metabolism,
56(1):115-121. (2007)
14) Nishida Y, Taketani Y, Yamanaka-Okumura H, Imamura F, Taniguchi A, Sato T, Shuto E,Nashiki K, Arai H, Yamamoto H, Takeda E. Acute effect of oral phosphate loading on serum
fibroblast growth factor 23 levels in healthy men. Kidney Int., 70(12):2141-2147. (2006)

13) Sato T, Yamamoto H, Sawada N, Nashiki K, Tsuji M, Muto K, Kume H, Sasaki H, Arai H,Nikawa T, Taketani Y, Takeda E. Restraint stress alters the duodenal expression of genes
important for lipid metabolism in rat. Toxicology. 2006;227(3):248-261. [Oct] IF 2.605
12) Sato T, Yamamoto H, Sawada N, Nashiki K, Tsuji M, Nikawa T, Arai H, Morita K, TaketaniY, Takeda E. Immobilization decreases duodenal calcium absorption through a 1,25dihydroxyvitamin D-dependent pathway. J Bone Miner Metab., 24(4):291-299. (2006)
11) Yamanaka-Okumura H, Nakamura T, Takeuchi H, Miyake H, Katayama T, Arai H, Taketani
Y, Fujii M, Shimada M, Takeda E. Effect of late evening snack with rice ball on energy
metabolism in liver cirrhosis. Eur J Clin Nutr., 60(9):1067-1072. (2006)
10) Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K,Pike JW, Kato S, Takeda E. Alternative promoters and renal cell-specific regulation of themouse type IIa sodium-dependent phosphate cotransporter gene. Biochim Biophys Acta.,1732(1-3):43-52. (2005)
9) Nashiki K, Taketani Y, Takeichi T, Sawada N, Yamamoto H, Ichikawa M, Arai H, Miyamoto
K, Takeda E. Role of membrane microdomains in PTH-mediated down-regulation of NaPiIIa in opossum kidney cells. Kidney Int.,68(3):1137-1147. (2005)
8) Arai H, Mizuno A, Matsuo K, Fukaya M, Sasaki H, Arima H, Matsuura M, Taketani Y, DoiT, Takeda E. Effect of a novel palatinose-based liquid balanced formula (MHN-01) on
glucose and lipid metabolism in male Sprague-Dawley rats after short- and long-term
ingestion. Metabolism, 53(8):977-983. (2004)
7) Takeda E, Yamamoto H, Nashiki K, Sato T, Arai H, Taketani Y. Inorganic phosphatehomeostasis and the role of dietary phosphorus. J Cell Mol Med., 8(2):191-200. (2004)
6) Taketani Y, Nomoto M, Yamamoto H, Isshiki M, Morita K, Arai H, Miyamoto K, Kato S,Takeda E. Increase in IP3 and intracellular Ca2+ induced by phosphate depletion in LLC-PK
1 cells. Biochem Biophys Res Commun., 305(2):287-291. (2003)
5) Kubota M, Yoshida S, Ikeda M, Okada Y, Arai H, Miyamoto K, Takeda E. Association
between two types of vitamin D receptor gene polymorphism and bone status in
premenopausal Japanese women. Calcif Tissue Int., 68(1):16-22. (2001)
4) Arai H, Miyamoto KI, Yoshida M, Yamamoto H, Taketani Y, Morita K, Kubota M, Yoshida
S, Ikeda M, Watabe F, Kanemasa Y, Takeda E. The polymorphism in the caudal-related
homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene. J BoneMiner Res., 16(7):1256-1264. (2001)
3) Katai K, Miyamoto K, Kishida S, Segawa H, Nii T, Tanaka H, Tani Y, Arai H, Tatsumi S,Morita K, Taketani Y, Takeda E. Regulation of intestinal Na+-dependent phosphate cotransporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3. Biochem J., 343 Pt
3:705-712. (1999)
2) Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K, Tonai T, Nishisho T,Mori S, Takeda E. A vitamin D receptor gene polymorphism in the translation initiation
codon: effect on protein activity and relation to bone mineral density in Japanese women. JBone Miner Res., 12(6):915-921. (1997)
1) Katai K, Segawa H, Haga H, Morita K, Arai H, Tatsumi S, Taketani Y, Miyamoto K, HisanoS, Fukui Y, Takeda E. Acute regulation by dietary phosphate of the sodium-dependent
phosphate transporter (NaP(i)-2) in rat kidney. J Biochem (Tokyo), 121(1):50-55. (1997)