https://dfns.u-shizuoka-ken.ac.jp/graduate/laboratory/95.html
CURRICULUM VITAE
Norio OHASHI, Ph.D.
Lab. Address:
Laboratory of Microbiology, School of Food and Nutritional Sciences, University ofShizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan
Tel.: +81-54-264-5553
FAX: +81-54-264-5553
Email: ohashi(at)u-shizuoka-ken.ac.jp
Education:
B. S., Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, 1981
M.S., Pharmacology, Kanazawa University, 1984
Degree:Ph.D., Pharmacology, University of Tokyo, 1992
Career Statement:
Professor, University of Shizuoka, 2006-present• School of Food and Nutritional Sciences, 2008-present• Graduate School of Integrated Pharmaceutical and Nutritional Sciences,
Graduate Division of Nutritional and Environmental Sciences,
Department of Food and Nutritional Sciences, 2012-present• Graduate School of Nutrition and Environmental Sciences, 2006-2012• Institute for Environmental Sciences, 2006-2008
Associate Professor, University of Shizuoka, 2002-2006• Graduate School of Nutrition and Environmental Sciences, 2002-2006• Institute for Environmental Sciences, 2002-2006
Research Scientist (Adjunct Assistant Professor), the Ohio State University, 1997-2002• Department of Veterinary Biosciences
Research Associate, Niigata University of Pharmacy and Applied Life Sciences, 19841996• College of Pharmaceutical Sciences
Major Research Interest:• Applied Microbiology, especially functional analysis of bifidobacteria & lactic acid bacteria• Microbiological Food Sciences, especially effect of functional foods through intestinal
microbiota on human health.
• Medical Microbiology, especially epidemiology and intracellular parasitism of pathogenic
bacteria that cause food-borne or tick-borne infectious disease.

Publication List:(2012-present; Publication order based on recently accepted date)
1. Su H, Kubo K, Sakabe S, Mizuno S, Komiya N, Akachi S, Fujita H, Sato K, Kawabata
H, Nagaoka H, Ando S, Ohashi N. Serologic evidence of human exposure to ehrlichiosis
agents in Japan. Emerg Infect Dis. 28, 2355-2357 (2022)
2. 川上万里, 池田房雄, 藤岡真一, 藤田博己, 木田浩司, 大橋典男. 胆道感染症の併発が疑われたアナプラズマ症の 1 例. 感染症学雑. 96, 29-33 (2022)
3. Gaowa, Wulantuya, Sato K, Liu D, Cui Y, Yin X, Zhang L, Li H, Wang T, Liu R, Wu L,Lu S, Gao T, Zhang Z, Cao M, Wang G, Li C, Yan D, Ohashi N, Ando S, Kawabata H.
Surveillance of Borrelia miyamotoi-carrying ticks and genomic analysis of isolates inInner Mongolia, China. Parasit Vectors. 14, 368 (2021)
4. Tai H, Su H, Takamoto N, Fujita H, Takano A, Oishi S, Abe F, Ando S, Ohashi N. Growth
characteristics of Rickettsia species LON strains closely related to Rickettsia japonica
isolated from Haemaphysalis longicornis ticks in mouse-derived L929 and humanderived THP-1 host cell lines. Jpn J Infect Dis. Jpn J Infect Dis. 74, 102-109 (2021)
5. Su H, Onoda E, Tai H, Fujita H, Sakabe S, Azuma K, Akachi S, Oishi S, Abe F, Ando S,Ohashi N. Diversity unearthed by estimated molecular phylogeny and ecologicallyquantitative characteristics of uncultured Ehrlichia bacteria in Haemaphysalis ticks,
Japan. Sci Rep. 11, 687 (2021)
6. Matsuzaki K, Iwai K, Yoshikawa Y, Shimamura Y, Miyoshi N, Hiramoto S, Asada K,
Fukutomi R, Su H, Ohashi N. Wheat bran intake enhances the secretion of bacteriabinding IgA in a lumen of the intestinal tract by incrementing short chain fatty acidproduction through modulation of gut microbiota. Nat Prod Commun. 15, 1-11 (2020)
7. Su H, Ito K, Kawarasaki Y, Morita H, Nose H, Iketa K, Nakadouzono F, Gokuden M,Kamiyama, S., Tokaji, A., Rikitake, Y., Kawaguchi, T., Umekita, K., Oishi, S., Abe, F.,
Kanda T, Kawabata H, Ando S, Ohashi N. Insight of diagnostic performance using B-cell
epitope antigens derived from triple P44-related proteins of Anaplasma phagocytophilum.
Diagn Microbiol Infect Dis, 95, 125-130 (2019)
8. Su H, Sato A, Onoda E, Fujita H, Sakabe, S, Akachi S, Oishi S, Abe F, Kanda T,Shimamura Y, Masuda S, Ohashi N. Molecular detection and characterization ofp44/msp2 multigene family of Anaplasma phagocytophilum from Haemaphysalis
longicornis in Mie Prefecture, Japan. Jpn J Infect Dis. 72, 199-202 (2019)
9. Taira M, Kadosaka T, Sato H, Ohashi N, Fujita H, Saijo M, Monma N, Ando S, Kawabata

H. Isolation and molecular detection of Ehrlichia species from ticks in western, central,and eastern Japan. Tick Tick Borne Dis. 10, 344-351 (2019)10. Shimada M, Takamoto N, Su H, Sasahara H, Shimamura Y, Ando S, Ohashi N.
Predominant shift of different P44-expressing Anaplasma phagocytophilum in infected
HL-60, THP-1, NB4, and RF/6A cell lines. Jpn J Infect Dis. 72, 73-70 (2019)11. Yoshikawa Y, Katayanagi Y, Kamiya M, Yamamoto Y, Fukutomi R, Imai S, Miyoshi N,Ohashi N. Tomato saponin supplementation ameliorates the development of experimental
arthritis by regulating inflammatory responses. J Funct Foods. 49, 458-464 (2018)
12. Gaowa, Wulantuya, Yin X, Guo S, Ding C, Cao M, Kawabata H, Sato K, Ando S, Fujita
H, Kawamori F, Su H, Shimada M, Shimamura Y, Masuda S, Ohashi N. Spotted fevergroup Rickettsia in Inner Mongolia, China, 2015-2016. Emerg Infect Dis. 24, 2105-2107(2018)
13. Shimamura Y, Utsumi M, Hirai C, Nakano S, Ito S, Tsuji A, Ishii T, Hosoya T, Kan T,Ohashi N, Masuda S. Binding of catechins to staphylococcal enterotoxin A. Molecules.
9:23(5). pii: E1125 (2018)
14. Kawamori F, Shimazu Y, Sato H, Monma N, Ikegaya A, Yamamoto S, Fujita H, Morita
H, Tamaki Y, Takamoto T, Su H, Shimada M, Shimamura Y, Masuda S, Ando S, Ohashi
N. Evaluation of diagnostic assay for rickettsioses using duplex real-time PCR in multiple
laboratories in Japan. Jpn J Infect Dis. 71, 267-273 (2018)
15. Gaowa, Wulantuya, Yin X, Cao M, Guo S, Ding C, Yuhua L, Jianchang L, Kawabata H,
Ando S, Su H, Shimada M, Takamoto N, Shimamura Y, Masuda S, Ohashi N. Case ofhuman infection with Anaplasma phagocytophilum in Inner Mongolia, China. Jpn J InfectDis. 71, 155-157 (2018)16. Shimamura Y, Hirai C, Sugiyama Y, Shibata M, Ozaki J, Murata M, Ohashi N, Masuda
S. Inhibitory effects of food additives derived from polyphenols on staphylococcal
enterotoxin A production and biofilm formation by Staphylococcus aureus. Biosci
Biotechnol Biochem. 81, 2346-2352 (2017)17. Iwai K, Yoshikawa Y, Miyoshi M, Fukutomi R, Asada K, Ohashi N. Effects of short-term
intake of wheat bran with different particle sizes on the murine intestinal environment.
Food Sci Technol Res. 23, 733-742 (2017)18. Shimamura Y, Hirai C, Sugiyama Y, Utsumi M, Yanagida A, Murata M, Ohashi N,Masuda S. Interaction between various apple procyanidin and staphylococcal enterotoxin
A and their inhibitory effects on toxin activity. Toxins (Basel). 9(8). (2017)19. Yamano K, Ito T, Kiyanagi K, Yamazaki H, Sugawara M, Saito T, Ohashi N, ZamotoNiikura A, Sato K, Kawabata H. Case Report: Clinical Features of a Case of suspected
Borrelia miyamotoi disease in Hokkaido, Japan. Am J Trop Med Hyg. 97, 84-87 (2017)
20. Waki N, Kuwabara Y, Yoshikawa Y, Suganuma H, Koide H, Oku N, Ohashi N.
Amelioration of Citrobacter rodentium proliferation in early stage of infection in miceby pre-treatment with Lactobacillus brevis KB290 and verification using in vivo

bioluminescence imaging. FEMS Microbiol Lett. 364(6). (2017)21. Sakakibara Y, Sen E, Sato K, Kawabata H, Ohashi N, Masuzawa T. Detection andcharacterization of emerging relapsing fever pathogen, Borrelia miyamotoi, from Ixodes
ricinus tick on rural Trakya (Thrace) region of North western Turkey. Vector Borne
Zoonotic Dis. 16, 797-799 (2016)
22. Khasnatinov MA, Danchinova GA, Takano A, Kawabata H, Ohashi N, Masuzawa T.
Prevalence of Borrelia miyamotoi in Ixodes persulcatus in Irkutsk City and its
neighboring territories, Russia. Ticks Tick Borne Dis. 7, 394-397 (2016)
23. Wu D, Wuritu, Yoshikawa Y, Gaowa, Kawamori F, Ikegaya A, Ohtake M, Ohashi M,Shimada M, Takada A, Iwai K, Ohashi N. Molecular and serological survey ofRickettsiales bacteria in wild sika deer (Cervus nippon nippon) in Shizuoka prefecture,
Japan: High prevalence of Anaplasma species. Jpn J Infect Dis. 68, 434-437 (2015)
24. Kato A, Sakakibara H, Tsuboi H, Tatsumi A, Akimoto M, Shimoi K, Ishii T, Kaneko H,Nakayama T, Ohashi N. Depressive symptoms of female nursing staff working instressful environments and their association with serum creatine kinase and lactate
dehydrogenase-a preliminary study. BioPsychoSocial Medicine 8, 21 (2014)
25. Todoroki K, Ishii Y, Miyauchi C, Kitagawa S, Min JZ, Inoue K, Yamanaka T, Suzuki K,Yoshikawa Y, Ohashi N, Toyo’oka T. Simple and sensitive analysis of histamine andtyramine in Japanese soy sauces and their intermediates using the stable isotope dilution
HILIC−MS/MS method. J Agric Food Chem. 62, 6206−6211 (2014)
26. Tanaka K, Ohgo Y, Katayanagi Y, Yasui K, Hiramoto S, Ikemoto H, Nakata Y, Miyoshi
N, Isemura M, Ohashi N, Imai S. Anti-inflammatory effects of green soybean extract
irradiated with visible light. Sci Rep. 4, 4732 (2014)
27. Gaowa, Yoshikawa Y, Ohashi N, Wu D, Kawamori F, Ikegaya A, Watanabe T, Saitoh K,Takechi D, Murakami Y, Shichi D, Aso K, Ando S. Anaplasma phagocytophilum
antibodies in humans, Japan, 2010-2011. Emerg Infect Dis. 20, 508-509 (2014)
28. Ohashi N, Gaowa Wuritu, Kawamori F, Wu D, Yoshikawa Y, Chiya S, Fukunaga K,Funato T, Shiojiri M, Nakajima H, Hamauzu Y, Takano A, Kawabata H, Ando S,Kishimoto T. Human granulocytic anaplasmosis in Japan. Emerg Infect Dis. 19, 289-292(2013)
29. Gaowa, Ohashi N, Aochi M, Wuritu, Wu D, Yoshikawa Y, Kawamori F, Honda T, Fujita
H, Takada N, Oikawa Y, Kawabata H, Ando S, Kishimoto T. Rickettsiae in ticks, 20072011 Japan. Emerg Infect Dis 19, 338-340 (2013)
30. Shinohara M, Uchida K, Shimada S, Tomioka K, Suzuki N, Minegishi T, Kawahashi S,
Yoshikawa Y, Ohashi N. Application of a simple method using minute particles ofamorphous calcium phosphate for recovery of norovirus from cabbage, lettuce, and ham.
J Viorol Methods 187, 153-158 (2013)
31. Ybañez AP, Sato F, Nambo Y, Fukui T, Masuzawa T, Ohashi N, Matsumoto. K.,
Kishimoto. T., and Inokuma. H. Survey on Tick-Borne Pathogens in ThoroughbredHorses in the Hidaka District, Hokkaido, Japan. J Vet Med Sci. 75, 11-15 (2013)
32. Hiroi M, Matsui S, Kubo R, Iida N, Noda Y, Kanda T, Sugiyama, K., Hara-Kudo Y,Ohashi N. Factors for occurrence of extended-spectrum β-lactamase-producing
Escherichia coli in broiler. J Vet Med Sci. 74, 1635-1637 (2012)
33. Sakakibara H, Suzuki A, Kobayashi A, Motoyama K, Matsui A, Sayama K, Kato A,Ohashi N, Akimoto M, Nakayama T, Shimoi K. Social isolation stress induces hepatic
hypertrophy in C57BL/6J mice. J Toxicol Sci. 37, 1071-1076 (2012)
34. Hiroi M, Takahashi N, Harada T, Kawamori F, Iida N, Kanda T, Sugiyama K, Ohashi N,Hara-Kudo Y, Masuda T. Serotype, Shiga toxin (Stx) type, and antimicrobial resistanceof Stx-producing Escherichia coli isolated from humans in Shizuoka Prefecture, Japan(2003-2007). Jpn J Infect Dis. 65, 198-202 (2012)
35. Gaowa, Wuritu, Wu D, Yoshikawa Y, Ohashi N, Kawamori F, Sugiyama K, Ohtake M,Ohashi M, Yamamoto S, Kitano T, Takada N, Kawabata H. Detection and characterizationof p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected
ticks and wild deer in Japan, Jpn J Infect Dis. 65, 79-83 (2012)
36. Hiroi M, Yamazaki F, Harada T, Takahashi N, Iida N, Noda Y, Yagi M, Nishio T, KandaT, Kawamori F, Sugiyama K, Masuda T, Hara-Kudo Y, Ohashi N. Prevalence of extendedspectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in foodproducing animals. J Vet Med Sci. 74:189-195 (2012)