CellAppendix:TERMS and CONDITIONS
2016.07.12

Human iPS : HPS0354-361(1) The RECIPIENT Scientist belongs to a not-for-profit academic organization (i.e. a university or another institution of higher
education or any non-profit scientific or educational organization, including government agencies).
(2) The RECIPIENT recognizes and acknowledges that KYOTO UNIVERSITY retains the ownership of BIOLOGICALRESOURCE (“ORIGINAL CELL”) and any cell reproduced or propagated directly or indirectly from the ORIGINAL CELL
regardless of maintaining
identity with the ORIGINAL CELL (“CELL”). The ORIGINAL CELL and CELL are referred to herein as the “MATERIAL”.
(3) The RECIPIENT shall not use the MATERIAL for any purpose other than academic research purpose of conducting theresearch set forthin the MATERIAL TRANSFER AGREEMENT (“RESEARCH PROJECT”).
(4) The RECIPIENT acknowledges that this Agreement is not the agreement to license the intellectual property rights owned byKYOTO UNIVERSITY to the RECIPIENT. The RECIPIENT also acknowledges that no express or implied licenses or otherrights are provided to the RECIPIENT from KYOTO UNIVERSITY to use the MATERIAL or any related patents of KYOTO
UNIVERSITY for commercial purposes.
(5) The RECIPIENT acknowledges that the MATERIAL was created through introduction of transgenes and that any experimentswith implantation or inoculation of the MATERIAL into living organisms will be deemed recombinant DNA experiment. TheRECIPIENT agree to comply with all laws, rules and regulations applicable to perform recombinant DNA experiment andsecure necessary approval before conducting such experiments.
(6) The RECIPIENT shall obtain the approval of the applicable institutional review board, institutional ethical committee and/or
other committees of the RECIPIENT, based on its internal rules to use the MATERIAL and/or any derivatives, including but notlimited to RNAs, DNAs and/or cells differentiated from the MATERIAL (“DERIVATIVE”).
(7) The RECIPIENT agrees that the MATERIAL and DERIVATIVE;a) will not be used to create human embryos;b) will not be used to create human admixed embryos with embryos of animals including human;c) will not be used to induce differentiation to germ cells; andd) will not be used in human subjects for any purpose.
(8) The MATERIAL and DERIVATIVE shall be used only by the RECIPIENT Scientist and others working under RECIPIENT
Scientist’s direct supervision at the RECIPIENT Scientist’s laboratory, including others of not-for-profit organizations working
together to carry out the collaborative research on RESEARCH PROJECT at the RECIPIENT Scientist’s laboratory, and shallnot be used by, as well as shall not be provided to anyone else within or outside the RECIPIENT organization without the priorwritten consent of KYOTO UNIVERSITY.
It is recognized by the RECIPIENT that such transfer may require an appropriate agreement between KYOTO UNVIERSITY
or the RECIPIENT and the third party recipient(s).
(9) The MATERIAL and DERIVATIVE shall not be used for commercial purpose, including conducting collaborative research orcontract research with for-profit organization(s) without the prior written consent of KYOTO UNIVERSITY.
(10) The DERIVATIVE shall not be used for any purpose other than RESEARCH PROJECT without the prior written consent ofKYOTO UNIVERSITY.
(11) At the time of publication of the result from using the MATERIAL and/or DERIVATIVE in the RESEARCH PROJECT,whether in print or in electronic form, the RECIPIENT shall provide a copy of each publication to KYOTO UNIVERSITY.
Medical Applications Promoting Office
Center for iPS Cell Research and Application (CiRA), Kyoto University
E-mail: cira-keiyaku@cira.kyoto-u.ac.jp
FAX: 81-75-366-7180
URL: http://www.cira.kyoto-u.ac.jp/e/index.html(12)The RECIPIENT agrees to cite the papers specified below and provide appropriate acknowledgement of the source of theMATERIAL and/or DERIVATIVE in all publications.
Citation: Okita K, et al. An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood andPeripheral Blood Cells. Stem Cells. 2012 Nov 29.

Cell TERMS and CONDITIONS
2016.07.12(13) If the RECIPIENT desires to file patent application(s) claiming inventions made by the RECIPIENT through the use of theMATERIAL
and/or DERIVATIVE, the REIPIENT agrees to notify KYOTO UNIVERSITY after the publication of the patent application.
(14) The RECIPIENT agrees to grant to KYOTO UNIVERSITY royalty-free licenses, which are acquired by its use of theMATERIAL and/or DERIVATIVE, for teaching and academic research purposes, and will not exercise their intellectual
property rights to KYOTO UNIVERSITY.
(15) The RECIPIENT agrees that KYOTO UNIVERSITY makes no representations and extends no warranties of any kind, either
expressed or implied. There are no express or implied warranties of merchantability or fitness for a particular purpose, or that theuse of the MATERIAL and/or DERIVATIVE will not infringe any patent, copyright, trademark, or other proprietary rights. TheRECIPIENT assumes all liability for damages which may arise from its use, storage or disposal of the MATERIAL andDERIVATIVE. KYOTO UNIVERSITY will not be liable to the RECIPIENT for any loss, claim or demand made by theRECIPIENT, or claim or demand by any other party made against the RECIPIENT, due to or arising from the use of theMATERIAL and DERIVATIVE by the RECIPIENT.
(16) The RECIPIENT agrees that RIKEN informs to KYOTO UNIVERSITY of the RECIPIENT name, the RECIPIENTinstitution, the title of the RESEARCH PROJECT and the date of distribution.