書類

その１概略情報

尾崎幸洋

1．

専門分野：
「分子分光学」、「物理化学」、「分析化学」

2．

豊田理研での研究テーマ：凝集体の遠紫外分光法の基礎と応

用
3．

経歴

学歴；
1973 年 3 月

大阪大学理学部化学科卒業

1973 年 4 月

大阪大学大学院理学研究科 無機及び物理化学専

攻 修士課程 進学
1975 年 3 月

大阪大学大学院理学研究科 無機及び物理化学専

攻 修士課程 修了（理学修士）
1975 年４月

大阪大学大学院理学研究科 無機及び物理化学専

攻 博士課程 進学
1978 年 6 月

大阪大学大学院理学研究科 無機及び物理化学専

攻 博士課程 修了（理学博士）
職歴1978 年 9 月 カナダ国立研究所（NRC）任期付き研究員（～
1981 年 1 月）

1981 年 4 月

東京慈恵会医科大学 助手

1988 年 4 月

東京慈恵会医科大学 講師

1989 年 4 月

関西学院大学理学部 助教授

1993 年 4 月

関西学院大学理学部 教授

1993 年 7 月

プリンストン大学客員上級研究員（〜9 月まで）

2002 年 4 月

学部改変により同理工学部 教授

2006 年 4 月 関西学院大学理工学部 理工学部長（2010 年 3 月まで）
2010 年 4 月

学校法人関西学院 常任理事 (2018 年 3 月まで)

2013 年 4 月

関西学院大学副学長（2018 年 3 月まで）

2018 年 3 月

関西学院大学定年退職

2018 年 4 月

関西学院大学名誉教授

2018 年 9 月〜12 月オーストリア、インスブルック大学招聘教授

２．これまでの研究成果
私はこの約 45 年の間、自ら新しい分子分光学の分野を開拓し、自ら独創的な分光システムを創案し、また自ら新規な応用分野を切り開き、分子分光学のフロントランナーの一人として活躍してきた。その研究内容は、１）凝集相の新しい電子分光法・振動分光法の開拓（減、２）電子分光法・振動分光法の原理の探求（表面増強ラマ
衰全反射―遠紫外分光法など）
ン散乱の機構解明など）、３）スペクトル解析法の提案、４）電子分光法・振動分光法の物
理化学、分析化学、ナノ物質化学、生物医学などへの応用など、極めて広範囲にわたる(1)。
私は遠紫外から遠赤外/テラヘルツに至るほとんど全ての領域の凝集体の分子分光学の研究を行っている世界的に見ても珍しい存在である。私の分子分光学研究における戦略の一
つは、未開拓、未踏峰の領域の研究に力を入れるという点である(1)。例えば 140-200 nm の遠紫外領域における凝集相の分光はほとんど未開拓であったが、私はこの領域に減衰全反射（ATR）法を導入することにより、凝集相の遠紫外分光法を確立した。私はまた包括的に
分子分光学（振動分光学と電子分光学）の研究を行い、スケールの大きな研究を発展させた。
特に力を入れた分光法は、ラマン、遠紫外、近赤外、遠赤外/テラヘルツ分光法などであるが、ここでは、1) 遠紫外～遠赤外/テラヘルツの全スペクトル領域とラマン分光法に共通する研究、2) 凝集相における遠紫外分光法の創成―新しい σ 電子化学の構築をめざす、3)分子分光法としての近赤外分光法の確立―基礎、装置開発、量子化学の応用に関する研究、
4) 表面増強ラマン散乱 (Surface-enhanced Raman Scattering; SERS)、チップ増強ラマン散乱 (Tip-enhanced Raman Scattering; TERS)の機構解明とそれらの応用に関する研究、5)
遠赤外/テラヘルツ、低波数ラマン、量子化学計算法を用いた高分子の高次構造、分子間相互作用の研究、6）ラマン分光法、近赤外分光法の生物医学への応用、の 6 項目に焦点を絞り研究成果を説明する(1)。
(1）遠紫外～遠赤外/テラヘルツの全領域とラマン分光法に共通する研究
全領域とラマン分光に共通する研究として、1）量子化学の分子分光学への応用に関する研究、2）全領域とラマン分光法に適用可能なスペクトル解析法の開発、3）異なる分光学領域
間のスペクトルの比較の研究を行った。量子化学の研究では、“「分子分光学」と「量子化学」に橋を架ける”というビジョンを立てた（1-７）
。このテーマの目的は、量子化学の分子分光学研究における有用性を深めかつその応用範囲を広めるとともに、非調和性の考慮、巨大分子の取り扱い、分子間、分子内相互作用の取り扱いなどの幅広い分野に共通する課題の解決に努めることである。具体的な研究成果としては、(i)これまで赤外、ラマン中心であった非調和性を含む量子化学計算を近赤外まで拡げ、倍音、結合音によるバンドからなる近赤外スペクトルのシミュレーションに成功し、バンドの帰属や強度の研究を行った（4,5）
。(ii)ポリマーの遠赤外/テラヘルツ、ラマン、赤外スペクトルにおける分子断片化法の適用 (6,7)。
この方法を用いることにより、巨大分子のスペクトル計算、分子間相互作用を含む分子の計算を幅広い領域で可能とした。(iii) 紫外、遠紫外領域のスペクトル解析に SymmetryAdapted Cluster/Configuration Interaction (SAC-CI)法を適用し、Rydberg 状態を含む電子
状態、電子遷移研究を発展させた（3）。

図１ メタノールの近赤外スペクトルー実験スペクトル(0.005M の四塩化炭素溶液)と計算
スペクトルの比較(4)。
図１は量子化学計算の近赤外分光法への応用例で、メタノールの実験スペクトルと計算
スペクトルの結果を比較したものである。非調和性を考慮した量子化学計算により倍音、結合音からなるメタノールの近赤外スペクトルが見事に再現され、バンドの帰属も明らかになった(4)。
2）の全領域とラマン分光法に適用可能なスペクトル解析法の開発の研究では、ケモメト
リックス法と二次元相関分光法の研究で大きな成果を得た。前者ではスペクトルデータの２方向、すなわち波長方向、サンプル方向において有効な情報の選択・抽出を行い高精度の検量線を実現することを目指した。その中で最も注目を集めているのは、我々（Jiang ら）
が提案した Moving Window Partial Least Squares Regression (MWPLSR)法である(8)。この方法は、赤外、ラマン、近赤外スペクトル等においてケモメトリックスを適用するときの波長選択法として非常によく用いられている。
(2） 凝集相における遠紫外分光法の創成―新しい σ 電子化学を目指して
遠紫外領域には数々の電子許容遷移が観測される。しかし遠紫外域ではモル吸光係数が非常に大きいため、これまで大方、気相でスペクトル測定が行われてきた。凝集相にとっては
分子分光学の未踏領域となっていた(9)。
我々は減衰全反射 (Attenuated Total Reflection; ATR)法を基本原理とする遠紫外分光器を開発し、通常の紫外スペクトルでは吸収バンドを示さない水、アルカン、アルコールなど

ありとあらゆる分子の遠紫外スペクトルを凝集状態で測定できるようにした(3,9,10)。このようにして分子分光学の新しい分野の開拓に成功した (9) 。さらに量子化学計算を用いて、種々の有機化合物の電子状態の研究を実験と理論の両面から進めた。
我々は遠紫外分光法の研究で、６つの顕著な成果
図 2 ATR-遠紫外スペクトルを再現す
る量子化学計算により得られた n-ヘキ
サンの電子遷移にかかわる占有軌道および非占有軌道 (2)。

を挙げた(9)。1) 凝縮相における Rydberg 軌道が関与する電子状態の実験的・理論的研究(3)、 2) 分子間相互作用が分子の単結合骨格の価電子（σ電子）に与える影響の研究(10)、 3) 遠紫外分光法を用いた
水、水溶液、表面吸着水の研究(11,12)、4）遠紫外分

光法を用いた金属ナノ粒子修飾酸化チタンの電子状態と光触媒活性の研究(13)、 5) 遠紫外分光法の材料化学（高分子、カーボンナノ材料、イオン液体）への応用(3,14)、6) 遠紫外/
深紫外―表面プラズモン法の開発(15)。
我々（森澤ら）は開発した ATR 遠紫外分光器を用いてアルコール、アルカン、ケトン等の有機液体の遠紫外スペクトルを系統的に研究した(3,9,10)。液相と気相のスペクトルの比較や量子化学計算で求めた電子励起エネルギーなどから、遠紫外スペクトルの帰属法を確立した。アルカンの電子励起状態研究では 153 nm 付近に観測される吸収を HOMO-2 または HOMO-1 から 3p Rydberg（Ryd.と略す）への遷移であると帰属し、この遷移がアルカンのσ電子の状態を反映していることを示した（図 2）。この例のように遠紫外域における凝集相の Ryd.遷移の研究を精力的に行った (3,9,10)。
分子間相互作用が分子の単結合骨格の価電子（σ電子）に与える影響 に関する研究では、常温で液体のテトラデカン（C 14 H 30 ）の温度依存遠紫外スペクトルを固体の-80℃まで測定した(10)。この測定で温度変化に伴い、153 nm の遷移がなくなり、202、208 nm に新たな吸収が現れるという変化を観測した。この変化の原因を探るために、アルカン 2 分子を並べたものの電子遷移計算を行った。そして分子間距離を近づけたときに、実験で見られたよ
うな大きな長波長シフトが観測されることを示した。このことから、シフトの原因は、外側に張り出したσ軌道である HOMO-1 および HOMO-2 軌道が固体中の分子間相互作用により不安定化軌道と安定化軌道を作り、この二つの軌道間の遷移が低エネルギー側に観測されることによると結論した。このように遠紫外分光法でσ軌道の変化による遷移の変化を観測した例はこれまでにない。これはまさに新しいσ電子化学を開拓する第一歩となる成果である。
アルカンに限らず、アルコール、ケトン、アミドなどほとんどの有機分子、高分子が遠紫外領域に重要な遷移を示す。森澤らはこれらの物質について遠紫外分光法を用いて電子状態の研究を行った(3,9,10)。ナイロンの研究ではナイロンの水素結合が遠紫外スペクトルに与える影響について調べた(3b)。 さらに遠紫外分光法を用いた水、水溶液、表面吸着水の

研究 (12)や金属ナノ粒子修飾に伴う酸化チタンの電子状態変化と、それに対応した光触媒活性の増強についての研究も注目を集めている(13)。さらにイオン液体やカーボンナノ材
料、カーボンナノコンポジットなどの材料研究に展開している(14)。
以上のようにアルカンの固体でのスペクトル変化から HOMO の反発からエネルギーが不安定化すること、金属担持 TiO 2 でのスペクトル変化から金属ー触媒間の電子の流れを実測するなど、凝縮相で分子内の電子状態が変化し、電子の移動する様子を実験結果と量子化学計算から可視化することができた。これらの研究は化学における新たな研究領域を拓いたと言える。
(3）近赤外分光法の確立―その基礎、装置開発、量子化学の応用に関する研究
私は倍音、結合音、非調和性、振動ポテンシャルなど近赤外分光法の基礎研究を進めるとともに(16)、水素結合研究や溶液化学への応用(16-18)、表面プラズモン共鳴―近赤外分光法の提案(19)、ポータブル近赤外イメージングなどの装置開発(20)、スペクトル解析法の研究(8,21)、生命科学、高分子分析、医薬品分析、オンライン分析への応用などを行った。これらにより、90 年代には十分に独立した分光法と言える状態になかった近赤外分光法を、独立した分子分光法として確立させた。
(3)-1

倍音、結合音、非調和性、振動ポテンシャルに関する研究およびそれらの応用 近

赤外スペクトルには分子振動の倍音、結合音によるバンドが観測される。しかし倍音、結合音の帰属や強度の解析は非常に複雑であるため、これまで近赤外スペクトルに含まれる情報を的確に抽出することが難しかった。そこで我々は(Bec ら)非調和性を考慮した量子化学
計算によって近赤外スペクトルの再現、バンドの帰属を行った(4-6)。近赤外スペクトルの再現は図 1 に示したメタノールのような比較的簡単な化合物だけでなく、核酸塩基、長鎖
脂肪酸、天然物などかなり複雑なものも含まれる。量子化学の適用により、これまでバンドの帰属が非常に厄介であった近赤外スペクトルの解析に新しい道を切り開いた。
さらに量子化学計算を用いて水素結合の形成と溶媒効果の近赤外スペクトルに対する影響を解析した(22,23)。分子振動の非調和性や振動ポテンシャルには、分子への外的相互作
用の影響が表れやすい。我々（二見ら）は基本音と倍音の吸収強度の変化を比較することにより、水素結合と溶媒効果との識別を明確にすることができることを示した（図 3）。

図 3 基本音と倍音の水素結合形成に対する吸収強度の変化(3)-2 溶液化学への応用 我々（池羽田ら）は近赤外分光法の強みを生かし、液体分子の相溶性の研究を発展させた(18)。濃度差分スペクトルに基づく水素結合状態の解析や、疎水性部位の振動に注目する独自の視点によって、エタノールと水のように相溶の溶液に関しても、微視的には相分離に近い状態にあることを示した。
(3)-3 近赤外分光法の応用応用面でも純水(24)や生体中の水の研究、表面プラズモン共鳴―近赤外分光法の創案(19)、ポータブル近赤外イメージング装置の開発とその応用(20)、近赤外イメージングによるメダ
カの卵の血流の非染色イメージング(25)などにおいて注目すべき成果を挙げている。これらにより、それ迄は十分に独立した分光法と言える状態になかった近赤外分光法を、独立した
分子分光法として確立させたと言っても過言でない。
(4）表面増強ラマン散乱(Surface-enhanced Raman Scattering; SERS)、チップ増強ラマン
散乱(Tip-enhanced Raman Scattering; TERS)の機構解明とそれに基づく物理化学、分析化
学、ナノ物質化学、生体関連化学等への応用に関する研究(4)-1 表面増強ラマン散乱の機構解明

表面増強ラマン散乱 (Surface-enhanced Raman

Scattering; SERS)では、わずか分子 1 個からのラマン散乱の測定ができるので、SERS は基礎研究からも応用からも“夢の分光法”と言える。しかしこれまで SERS によるラマン散乱の増強のメカニズムが明らかでなかった。我々（伊藤ら）は、分子種に依存しない普遍的な理論として電磁増強理論に着目し、その実証研究を行った(26-28)。ラマン遷移は光励起遷移とラマン放射遷移の二つから構成される。それぞれの遷移では空間と分子は光子の受け渡しを行う。電磁増強とは空間の光子の状態密度を大きくしてこの受け渡しの効率を上げることである。金や銀ナノ粒子のプラズモン(伝導電子の集団振動)は高い伝導電子密度と長い
集団振動時間のために、光子の非常に大きな状態密度向上効果をもたらし、その結果、ラマン遷移確率が増大する。これが電磁増強理論である。ところでプラズモン共鳴の波長、スペクトル形状、偏光特性などはナノ粒子のサイズや形状に依存して大きく変化する。したがって、従来の集団ナノ粒子系を用いた SERS の実験に基づく増強原理検証の研究では、増強の原因 (プラズモン共鳴) が平均化され、増強の結果(SERS)との関係を直接捉えることができない。
伊藤らは、プラズモン共鳴を平均化することなく、単一分子を用いて電磁増強理論の検証が可能だとの着想を得た。そのため単一のナノ粒子 2 量体の電子顕微鏡測定、プラズモン
共鳴測定、SERS 測定が可能な実験装置系を構築し、多くの 2 量体の SEM イメージ、プラズモン共鳴スペクトル、SERS スペクトルを測定した。つぎに実験結果を計算条件として
SERS の再現を電磁解析計算 (有限差分時間領域法(FDTD)法) で行った（図 4）。具体的には実験的に観測されたプラズモン共鳴を計算で再現し、再現したプラズモン共鳴から状態
密度向上効果を導き、SERS スペクトルを算出した。この算出された SERS スペクトルと実験で得られた SERS スペクトルとを比較することで電磁増強効果の定量的検証を行った(26-28)。

図 4 を用いて検証結果を説明する。実験と計算に用いた銀ナノ粒子 2 量体をそれぞれ
図 4(a)と 4(f)に示す。SERS を引き起こしているプラズモン共鳴は、実験と計算 (図4(b)と 4(g)) とでよく一致した。図 4(c)4(e)は、１つの 2 量体について 3 つの励起

図 4(a) 銀ナノ粒子 2 量体の SEM イメージ、(b)実験的に測定されたプラズモン共鳴スペクトル、(c)-(e), 一個の 2 量体について三つの励起波長（532, 561, 633 nm）で測定したローダミンの SERS
スペクトル、(f) 計算に用いた銀ナノ粒子 2 量体、(g) 計算されたプラズモン共鳴スペクトル、(h)-(j)計算で再現された SERS スペクトル(28)波長 (532, 561, 633nm) で測定したローダミンの SERS スペクトルである。図 4(h)-4(j)は計算で再現された SERS スペクトルである。実験の SERS スペクトルの励起波長依存性が計算によって見事に再現されているのが分かる。たとえば、532nm 励起においては SERS の
基本音 (～560 nm)と禁制である倍音 (～630 nm)が似た強度となっている興味深い現象を再現している (図 4(c)と 4(h))。さらに 633 nm 励起においては、アンチストークス側の
SERS バンド強度がストークス側の SERS バンド強度を超えるという異常現象を再現している (図 4(e)と 4(j))。以上のように我々は電磁増強効果が SERS 発現において支配的である
ことを実証した(31,32)。以上の研究結果は、プラズモンを利用することで金属ナノ構造近傍の分子を孤立状態の時と比べて最大で 10 桁程度効率的に光と相互作用させることができることを意味する。したがって本研究は、適切なプラズモン共鳴条件を設定すれば、光の回折限界を超えた普遍的な超高感度測定ツールや超高効率光反応場を創生できることを示した。この研究は 1970 年代から 40 年あまり続いた SERS の増強メカニズムの研究を飛躍的に発展させたものとして国際的に非常に高く評価されている。またこの分野の基礎研究のみならず、応用に大きなインパクトを与えた(26-28)。
我々は電磁場増強理論のみならず化学増強機構や半導体励起ラマン散乱の機構と応用の研究でも注目すべき業績を挙げている(29,30)。半導体励起ラマン散乱は半導体を基板とした SERS で、感度は通常の SERS に比べれば低いが、再現性などについては優れている。
SERS の機構を電磁場増強理論と化学増強理論の両面から研究しているグループは世界的に見ても珍しい。
(4)-2 表面増強ラマン散乱の応用 我々は すでに 1990 年代に ”indirect SERS” 法を用いた
酵素イムノアッセイの研究で注目を集めた(31)。1998 年に発表した PCR によって増幅された二本鎖 DNA の定量分析の研究も高い評価を受けた。その後、SERS を用いたラベルフ
リー間接イムノアッセイやラベルフリータンパク質検出で大きな成果を挙げた(32)。最近
は、SERS を用いたラベルフリーの光学異性体判別法を提案し注目を集めている(33)。このSERS による光学異性体判別を可能とするのは、電荷移動に基づく化学増強機構による。さらに我々は世界で初めて 3 次元 SERS イメージングに成功した(34)。
(4)-3 チップ増強ラマン散乱の研究 我々はまた TERS の研究でも大きな貢献をしている。
例えば、TERS を用いた固液界面におけるナノスケールでの pH プロファイル測定 (35)は非常に大きな反響を受けている。TERS を用いたグラフェンやポリマーナノコンポジットの研究も有名である(36)。さらに最近、TERS を用いた光学異性体判別にも成功した。また超高真空、極低温下での TERS 測定装置を開発し、それを用いてグラフェンの構造、物性研究を行いつつある。このように我々の SERS,TERS 研究は、物理化学、分析化学、応用物理学、
ナノサイエンス/テクノロジー、生体関連化学などの幅広い分野に大きな波及効果を与えた。
(5) 遠赤外/テラヘルツ、低波数ラマン、量子化学計算法を用いた高分子の高次構造、分子間相互作用の研究遠赤外分光法を用いた高分子の研究は長い歴史を有するが、低波数域のバンドの帰属は
これまで十分ではなかった。我々は、バンドの帰属を明らかにし、バンドの帰属と高次構造、物性との関係を明らかにすることを目指した(6,7)。我々が用いた戦略は、バンドの帰属のために、吸収分光法（遠赤外/テラヘルツ）とラマン散乱、さらに両者の量子化学計算を合わせ用いるということである。高分子の量子化学計算を行うときに問題となるのは、分子量の大きい試料をいかに扱うか、分子間、分子内相互作用をいかに計算に取り込むかということである。そのために我々（山本ら）は Bouř らによって提案された分子断片化法を用いた。

図５Poly-(R)-3-hydroxybutyrate)(PHB)の低波数ラマンスペクトルと遠赤外スペクトルー実験スペクトルと計算スペクトルの比較

図５は生分解性ポリマーの一つである Poly-(R)-3-hydroxybutyrate)(PHB)の低波数ラマンスペクトルと遠赤外スペクトルとそれぞれの計算スペクトルを比較したものである(6)。
遠紫外、ラマンいずれの場合も実験スペクトルをよく再現している。この研究は-C=O…
CH 3 の弱い水素結合を計算にうまく取り込んだ点が評価される。
山本らは Poly(glycolic acid)(PGA)についても同様な研究を行い、実験スペクトルを分子断片化法により良く再現できることを示した。PGA と PHB のスペクトルの比較から、両者はいずれも C=O の面外変角振動を〜70-〜125 cm-1 に与えることが明らかになった。さらにこのバンドが、結晶格子の熱膨張とそれに伴う分子間相互作用の変化に敏感であることも分かった。このようにポリマーの熱膨張を直接的に見ることができるバンドは赤外、ラマンでは見出されておらず、低波数分光法で初めて見つけられたものである。
ナイロンの遠赤外スペクトルは 1960 年代から研究されている。モデル化合物の基準振動計算などを用いてバンドの帰属が試みられたが、100 cm-1付近のブロードなバンドについて
は、アミド結合によるものか CH 2 基によるものか議論があった。さらにアミド結合の面内振動なのか面外振動なのか分かっていなかった。我々の研究から、100 cm-1 付近のバンドの温度変化は、シフトによるものではなく、二本のバンドの強度比が温度とともに変化することによるものであることが分かった(7)。量子化学計算の結果からこれら二本のバンドはアミドの面外振動と CH 2 の振動の両方が関与していると帰属された。
(6）ラマン分光法、近赤外分光法の医学、生物学への応用
私は水野らとともに 40 年近く前に世界で初めて病気の発症メカニズム（ラットの白内障）の研究にラマン分光法を用いた（37,38）。その研究に関連してラットの水晶体の老化の研究も行い、白内障形成のメカニズムと老化のメカニズムの違いを明らかにした。加齢の場合は、水晶体の中の水の量が減少して行くのに対し、白内障形成の場合は、逆に水の量が増えていくことを非破壊でとらえることができた。また白内障形成の場合は、水晶体タンパク質のチロシン残基のいくつかがタンパク質に埋まった状態から露出した状態に変化することも明らかにした（図 6）。40 年も前に生体組織中の水の変動やタンパク質残基の微環境変化を非破壊でラマン分光法で捉えることができたというで、非常に注目を集めた。

図６（A）正常水晶体と（B）白内障の水晶体の加齢に伴うラマンスペクトルの変化（チロシンダブレットの領域）
その後 1990 年代前半に水野らとともに近赤外励起ラマン分光法をいち早くがん組織の研究に応用し、蛍光の妨害のほとんどないがん組織（脳腫瘍）のスペクトル測定に成功した（39）。グリア細胞腫のスペクトルでは多糖類によるバンドがかなり強くなっているが見られた。また神経細胞腫のスペクトルではヒドロキシアパタイトのバンドが 960 cm-1 に強く観測され、石灰化物質の沈着が確認された。これらの研究は、ラマン分光法を用いたがん組
織の研究の先駆けの一つである。
最近は、石垣らとともにラマン分光法の食道がんの早期発見に関係したがん診断への応用で注目を集める研究成果を発表した（40）。がんの早期発見では、形態学的変化が現れる
前の異常な分子組成変化を検出することが非常に重要に重要である。食道がんのステージ
0,1 のがん組織のスペクトルでは、グリコーゲン、コラーゲン、トリプトファンによるバンドの減少が見られた。スペクトルの解析には、通常のケモメトリックス法のほかにニューラルネットワークなども用いられ、ラマン分光法が初期食道がんの検出に有用であることが示された（40）。このほかに佐藤（英）らとともにラマンイメージングを用いたがん組織の研究を行っている（41）。また石垣らとともにラマン分光法の基礎生物学への応用研究に力を入れており、例えばラマン分光法を用いてマウス胚の成長の過程を非破壊、非ラベル標識
で分子レベルで研究することに成功した（42）。
私は近赤外分光法の医学応用でもパイオニア的研究成果を挙げた。1989年に近赤外分光法を用いて手の甲の血中ヘモグロビンの動態を非破壊、非侵襲で測定した(43)。この研究は、その後の医学分野の研究に大きな影響を与えた。さらに丸尾らの1990年代後半に手の腕の血糖値の非侵襲モニタリングの研究へとつながった。
以上のように私は未開拓、未発達な分子分光学分野に独創的なアイデア、研究手法で挑戦し、それを大きく発展させた。それにより幅広い学界あるいは社会へ一定の貢献をした
と言える。
文献

(1) (a) 尾崎幸洋、凝縮相の振動分光学と電子分光学の発展、分光研究、68, 81 (2019). (b) Y.
Ozaki, Recent Advances in Molecular Spectroscopy of Electronic and Vibrational Transitions inCondensed Phase and Its Application in Chemistry. Bull. Chem. Soc. Jpn. 92, 629 (2019).
(2) Y. Ozaki, M. J. Wojcik, J. Popp; Molecular Spectroscopy; A Quantum Chemistry Approach,
Wiley-VCH (2019).
(3) (a) M. Ehara, Y. Morisawa, ref.(2) p.119. (b) Y. Morisawa, M. Yasunaga, R. Fukuda, M. Ehara,
Y. Ozaki; Electronic transitions in liquid amides studied by using attenuated total reflection farultraviolet spectroscopy and quantum chemical calculation, J. Chem. Phys. 139, 154301 (2013).
(4) K. B. Bec, J. Grabska, C. W. Huck, Y. Ozaki, ref.(2), p.353.
(5) K. Bec, Y. Futami, M. J. Wojcik, T. Nakajima, Y. Ozaki; Spectroscopic and Computational
Study of Acetic Acid and Its Cyclic Dimer in the Near-Infrared Region, J. Phys. Chem. A, 120,
6170 (2016).
(6) S. Yamamoto, Y. Morisawa, H. Sato, H. Hoshina, Y. Ozaki; Quantum Mechanical Calculation ofIntermolecular Vibrational Modes of Crystalline Poly-(R)-3-Hydroxybutyrate Observed in LowFrequency Raman and Terahertz Spectra, J. Phys. Chem. B, 117, 2180 (2013).
(7) S. Yamamoto, E. Ohnishi, H. Sato, H. Hoshina, D. Ishikawa, Y. Ozaki; Low-Frequency
Vibrational Modes of Nylon 6 Studied by Using Infrared and Raman Spectroscopies and DFT
Calculations, J. Phys. Chem. B, 123, 5368 (2019).
(8) J. H. Jiang, R. J. Berry, H. W. Siesler, Y. Ozaki; Wavelength Interval Selection in Multicomponent
Spectral Analysis by Moving WindowPartial Least-Squares Regression with Applications to MidInfrared and Near-Infrared Spectroscopic Data, Anal. Chem., 74, 3555 (2002).

(9) Y. Ozaki, S. Kawata eds; Far- and Deep-Ultraviolet Spectroscopy: Springer (2015).
(10) Y. Morisawa, S. Tachibana, A. Ikehata, T. Yang, M. Ehara, Y. Ozaki; Changes in the Electronic
States of Low-Temperature Solid n‑Tetradecane: Decrease in the HOMO−LUMO Gap, ACS
Omega, 2, 618 (2017) .
(11) A. Ikehata, N. Higashi, Y. Ozaki: Direct Observation of the Absorption Bands of the FirstElectronic Transition in Liquid H 2 O and D 2 O by Attenuated Total Reflectance Far-UV Spectroscopy,
J. Chem. Phys., 129, 234510 (2008).
(12) T. Goto, A. Ikehata, Y. Morisawa, Y. Ozaki; Surface Effect of Alumina on the First Electronic
Transition of Liquid Water Studied by Far-Ultraviolet Spectroscopy, J. Phys. Chem. Lett. 6 1022
(2015).
(13) I. Tanabe, Y. Ozaki; Consistent changes in electronic states and photocatalytic activities of metal(Au, Pd, Pt)-modified TiO 2 studied by far-ultraviolet spectroscopy, Chem. Comm., 50, 2117 (2014).
(14) K. B. Bec´, Y. Morisawa, K. Kobashi, J. Grabska, I. Tanabe, Y. Ozaki, Electronic Spectra ofGraphene in Far- and Deep-Ultraviolet Region: Attenuated Total Reflection Spectroscopy and
Quantum Chemicl Calsulation Study, J. Phys. Chem. C, 122, 28998 (2018).
(15) I. Tanabe, Y. Tanaka, K. Watari, T. Hanulia, T. Goto, W. Inami, Y. Kawata, Y. Ozaki, Far- anddeep-ultraviolet surface plasmon resonance sensors working in aqueous solutions using aluminum thinfilms, Sci Rep., 7, 5934 (2017)(16) M. A. Czarnecki, Y. Morisawa, Y. Futami, Y. Ozaki; Advances in Molecular Structure andInteraction Studies Using Near-Infrared

Spectroscopy, Chem. Rev., 115, 9707 (2015).

(17) T. Gonjo, Y. Futami, Y. Morisawa, M. J. Wojcik, Y. Ozaki; Hydrogen Bonding Effects on the
Wavenumbers and Absorption Intensities of the OH Fundamental and the First, Second, and Third
Overtones of Phenol and 2,6-Dihalogenated Phenols Studied by Visible/Near- Infrared/Infrared
Spectroscopy, J. Phys. Chem. A, 115, 9845 (2011).
(18) A. Ikehata, C. Hashimoto, Y. Mikami, Y. Ozaki: Thermal phase behavior of triethylamine-water
mixtures studied by near-infrared spectroscopy: band shift of the first overtone of the C-H stretchingmodes and the phase diagram, Chem. Phys. Lett., 393, 403 (2004).
(19) A. Ikehata, T. Itoh, Y. Ozaki; Surface Plasmon Resonance Near-Infrared Spectroscopy, Anal.
Chem.76, 6461(2004).
(20) D. Ishikawa, K. Murayama, A. Kimie, T. Genkawa, M. Komiyama, S. G. Kazarian, Y. Ozaki;
Application of a Newly Developed Portable NIR Imaging Device to Dissolution Process Monitoringof Tablets. Anal. Bioanal. Chem. 405, 9401 (2013).
(21) Y. P. Du, Y. Z. Liang, J. H. Jiangc, R. J. Berry, Y. Ozaki; Spectral regions selection to improveprediction ability of PLS models by changeable size moving window partial least squares andsearching combination moving window partial least squares Anal. Chim. Acta, 501, 183 (2004).
(22) Y. Futami, Y. Ozaki, Y. Hamada, M. J. Wojcik, Y. Ozaki: Solvent Dependence of Absorption

Intensities and Wavenumbers of the Fundamental and First Overtone of NH Stretching Vibration of
Pyrrole Studied by Near-Infrared/Infrared Spectroscopy and DFT Calculations, J. Phys. Chem. A, 115,
1194 (2011).
(23) Y. Futami, Y. Ozaki, Y. Ozaki; Absorption Q1 Q2 intensity changes and frequency shifts offundamental and first overtone bands for OH stretching vibration of methanol upon methanol–pyridine
complex formation in carbon tetrachloride: analysis by near-infrared/infraredspectroscopy and density
functional theory calculations, Phys. Chem. Chem. Phys., 18, 5580 (2016).
(24) (a) V. H. Segtnan, S. Sasic, T. Isaksson, Y. Ozaki, Studies on the structure of water using twodimensional near-infrared correlation spectroscopy and principal component analysis, Anal. Chem.,
73, 3153 (2001). (b) S. Šašić, V. H. Segtnan, Y. Ozaki: Self-Modeling Curve Resolution Study ofTemperature-Dependent Near-Infrared Spectra of Water and the Investigation of Water Structure, J.
Phys. Chem. A, 106, 760 (2002).
(25) M. Ishigaki, P. Puangchit, Y. Yasui, A. Ishida, H. Hayashi, Y. Nakayama, H. Taniguchi, I.
Ishimaru, Y. Ozaki; Nonstaining blood flow imaging using optical interference due to doppler shift
and near-infrared imaging of molecular distribution in developing fish egg embryos. Anal. Chem.,
90, 5217 (2018).
(26) T. Itoh, Y. S. Yamamoto, and Y. Ozaki; Plasmon-enhanced spectroscopy of absorption andspontaneous emissions explained using cavity quantum optics, Chem. Soc. Rev. 46, 3904 (2017).
(27) T. Itoh, “Frontiers in Electromagnetic Mechanism of SERS”, in K. Kneipp, Y. Ozaki, Z.-Q. Tianeds., Recent Development in Plasmon-Supported Raman Spectroscopy-45 Years of Enhanced
Raman Signals, World Scientific (2018), p. 33.
(28) 伊藤民武、表面増強ラマン散乱、分光研究 64, 381 (2015).
(29) Y. Wang, J. Liu, Y. Ozaki, Z. Xu, B. Zhao; "Effect of TiO 2 on Altering Direction of Interfacial
Charge Transfer in a TiO2-Ag-MPY-FePc System by SERS", Angew. Chem. Int. Ed. 58, 8172
(2019).
(30) W. Ji, L. Li, W. Song, X. Wang, B. Zhao, Y. Ozaki; Enhanced Raman Scattering by ZnOSuperstructures: Synergistic Effect of Charge-Transfer and Mie Resonances, Angew. Chem. Int. Ed.
58, 14452 (2019).
(31) X. Dou, T. Takama, Y. Yamaguchi, H. Yamamoto, Y. Ozaki, Enzyme immunoassay

utilizing surface-enhanced Raman scattering of the enzyme reaction product, Anal. Chem.,
69, 1492 (1997).
(32) X. X. Han, B. Zhao, Y. Ozaki, Surface-enhanced Raman scattering for protein
detection, Anal. Bioanal. Chem., 394, 1719 (2009).

(33) Y. Wang, Z. Yu, W. Ji, Y. Tanaka, H. Sui, B. Zhao, Y. Ozaki: Enantioselective Discrimination of
Alcohols by Hydrogen Bonding: A SERS Study, Angew. Chem. Int. Ed., 53, 13866 (2014).

(34) S. Vantasin, W. Ji, Y. Tanaka, Y. Kitahama, M. Wang, K. Wongravee, H. Gatemala, S. Ekgasit,
Y. Ozaki; 3D SERS imaging using chemically-synthesized highly-symmetric nanoporous silver
microparticles, Angew. Chem. Int. Ed.,55, 8391 (2016).
(35) P. Pienpinijtham, S. Vantasin, Y. Kitahama, S. Ekgasit, Y. Ozaki; Nanoscale pH Profile at a
Solution/Solid Interface by Chemically ModifiedTip-Enhanced Raman Scattering, J. Phys. Chem. C,
120, 14663 (2016).
(36) S. Vantasin, I. Tanabe, Y. Tanaka, T. Itoh, T. Suzuki, Y. Kutsuma, K. Ashida, T. Kaneko Y. Ozaki:
Tip-Enhanced Raman Scattering of Local Nanostructure of Epitaxial Graphene Grown on 4H-SiC, J.
Phys. Chem. C, 118, 25809 (2014)(37) Y. Ozaki, A. Mizuno, Y. Kamada, K. Itoh, K. Iriyama: Laser Raman spectroscopic study of adiabetic cataractous lens, Chem. Lett., 887(1982).
(38) Y. Ozaki; Medical application of Raman spectroscopy, Appl. Spectrosc. Rev., 24, 259 (1988).
(39) A. Mizuno, H. Kitajima, K. Kawauchi, S. Muraishi, Y. Ozaki: Near-Infrared Fourier Transform
Raman Spectroscopic Study of Human Brain Tissues and Tumours, Journal of Raman Spectroscopy,
25, 25 (1994).
(40) M. Ishigaki, Y. Maeda, A. Taketani, B. B. Andriana, R. Ishihara, K. Wongravee, Y. Ozaki, H. Sato,
Diagnosis of early-stage esophageal cancer by Raman spectroscopy and chemometric techniques,
Analyst, 141, 1027 (2016).
(41) P. Meksiarun, M. Ishigaki, V.A.C. Huck-Pezzei, C.W. Huck, K. Wongravee, H. Sato, Y. Ozaki,
Comparison of multivariate analysis methods for extracting the paraffin component from theparaffin-embedded cancer tissue spectra for Raman imaging. Sci. Rep. 7, 44890 (2017).
(42) M. Ishigaki, Y. Hoshino, Y. Ozaki; Phosphoric acid and phosphorylation levels are potential
biomarkers indicating developmental competence of matured oocytes, Analyst, 144, 1527 (2019).
(43) Y. Ozaki, T. Matsunaga, T. Miura: Nondestructive and Noninvasive Monitoring of
Deoxyhemoglobin in the Vein by Use of a Near-Infrared Reflectance Spectrometer with a Fiber-Optic
Probe, Appl. Spectros., 46, 180 (1992).

4. 論文リスト（2013-2020 年 2 月）
(1) T. Suzuki, X. Yan, Y. Kitahama, H. Sato, T. Itoh, T. Miura, Y. Ozaki: Tip-Enhanced
Raman Spectroscopy Study of Local Interactions at the Interface of Styrene−Butadiene
Rubber/Multiwalled Carbon Nanotube Nanocomposites, The Journal of Physical
Chemistry, C, 117, 1436-1440 (2013)(2) K. Wongravee, T. Parnklang, P. Pienpinijtham, C. Lertvachirapaiboon,Y. Ozaki, C.
Thammacharoena and S. Ekgasita: Chemometric analysis of spectroscopic data on shapeevolution of silver nanoparticles induced by hydrogen peroxide, Phys. Chem. Chem. Phys.,
15, 4183-4189 (2013).
(3) Hideyuki Shinzawa, Kimie Awa, Isao Noda, Yukihiro Ozaki: Pressure-induced variationof cellulose tablet studied by two-dimensional (2D) near-infrared (NIR) correlation
spectroscopy in conjunction with projection pretreatment. Vibrational Spectroscopy, 65,
28-35 (2013).
(4) Shigeki Yamamoto, Yusuke Morisawa, Harumi Sato, Hiromichi Hoshina, and Yukihiro
Ozaki: Quantum Mechanical Interpretation of Intermolecular Vibrational Modes of
Crystalline Poly‑(R)‑3-Hydroxybutyrate Observed in Low- Frequency Raman andTerahertz Spectra, J. Phys. Chem. B, 117, 2180-2187 (2013).
(5) Chihiro Hashimoto, Akiyoshi Nagamoto, Takashi Maruyama, Naomi Kariyama, Yuma
Irisa,

AkifumiIkehata,andYukihiro

Ozaki:

Hydration

StatesofPoly(N‑isopropylacrylamide) and Poly(N,N‑diethylacrylamide) and Their Monomer
Units in Aqueous Solutions with Lower Critical Solution Temperatures Studied byInfrared Spectroscopy, Macromolecules, 46(3), 1041-1053 (2013).
(6) Hideyuki Shinzawa, Kimie Awa, Isao Noda, Yukihiro Ozaki , Multiple-Perturbation TwoDimensional Near-Infrared Correlation Study of Time-Dependent Water Absorption
Behavior of Cellulose Affected by Pressure, Applied Spectroscopy, 67,163-170 (2013).
(7) Kodai Murayama, Takuma Genkawa, Daitaro Ishikawa, Makoto Komiyama, and Yukihiro
Ozaki: A polychromator-type near-infrared spectrometer with a high-sensitivity and highresolution photodiode array detector for pharmaceutical process monitoring on the
millisecond time scale: Review of Scientific Instruments, 84, 023104-1-8 (2013).
(8) Miriam Unger, Harumi Sato, Yukihiro Ozaki, Dieter Fischer, Heinz W. Siesler:
Temperature-Dependent Fourier Transform Infrared Spectroscopy and Raman Mapping
Spectroscopy of Phase-Separation in a Poly(3-hydroxybutyrate)–Poly(L-Lactic Acid)
Blend: Applied Spectroscopy, 67, 2, 141-147(2013).
(9) Yasutaka Kitahama, Masato Kashihara, Tamitake Itoh, and Yukihiro Ozaki: SurfaceEnhanced Phosphorescence Measurement by an Optically Trapped Colloidal Ag
Nanoaggregate on Anionic Thiacarbocyanine H‑Aggregate: J. Phys. Chem. C, 117,

2460−2466 (2013).
(10) Yuta Miyamae, Marie Kawabata, Yumika Yamakawa and Yukihiro Ozaki: Review article:
Non-invasive assessment for photoaging and physiological aging of human skin and noninvasive estimation of the thickness of mice skin by near infrared diffuse-reflectancespectroscopy: NIR news, 24, 1, 11-14, (2013).
(11) Shigeki Yamamoto, Yusuke Morisawa, Harumi Sato, Hiromichi Hoshina and Yukihiro
Ozaki: Quantum Mechanical Interpretation of Intermolecular Vibrational Modes of
Crystalline Poly‑(R)‑3-Hydroxybutyrate Observed in Low- Frequency Raman andTerahertz Spectra: J. Phys. Chem., B, 117, 2180-2187 (2013).
(12) Dariusz Sobolewski, Edyta Proniewicz, Dominika Skołuba, Adam Prahl, Yukihiro Ozaki,
Younkyoo Kim and Leonard M. Proniewicz: Characterization of adsorption mode of new
B2 bradykinin receptor antagonists onto colloidal Ag substrate: Journal of Rman
Spectroscopy,44, 212-218(2013).
(13) Edyta Proniewicz, Prompong Pienpinijtham, Yukihiro Ozaki, Younkyoo Kim andLeonard M. Proniewicza: Influence of backbone length and synthetic mutations onorientation of neurotensin fragments adsorbed onto a colloidal silver surface: SERS
studies: Journal of Rman Spectroscopy, 44, 55-62(2013).
(14) Akifumi Uda, Shigeaki Morita, Yukihiro Ozaki: Thermal degradation of a poly(vinyl
alcohol) film studied by multivariate curve resolution analysis: Polymer, 54, 21302137(2013).
(15) Xinlei Yan, Tamitake Itoh, Shouyu Dai, Yukihiro Ozaki, Yan Fang: Cu,Mu doping effectto optical behavior and electronic structure of ZnO ceramic: Journal of Physics andChemistry of Solids, 74, 1127-1130 (2013).
(16) Edyta Proniewicz, Natalia Piergies, Yukihiro Ozaki, Younkyoo Kim, Leonard M.
Proniewicz: Investigation of adsorption mode of a novel group of N-benzylamino(boronphenyl) methylphosphonic acids using SERS: Molecular and Biomolecular
Spectroscopy, 103, 167-172(2013).
(17) Xiuxiang Gao, Yufeng Liu, Huizhen Li, Jiang Bian, Ying Zhao, Ye Cao, Yuezhi Mao, Xin
Li, Yizhuang Xu, Yukihiro Ozaki, Jinguang Wu: A cooperative hydrogen bonding systemwith a CAH…O hydrogen bond in ofloxacin: Journal of Molecular Structure,1040, 122–
128 (2013).
(18) Takeyoshi Goto, Akifumi Ikehata, Yusuke Morisawa, and Yukihiro Ozaki: Electronic
Transitions of Protonated and Deprotonated Amino Acids in Aqueous Solution in the
Region 145−300 nm Studied by Attenuated Total Reflection Far-Ultraviolet
Spectroscopy: J. Phys.Chem. , 117, 2517−2528 (2013).
(19) Hiromichi Hoshina, Shinya Ishii, Shigeki Yamamoto, Yusuke Morisawa, Harumi Sato,Tetsuji Uchiyama, Yukihiro Ozaki, and Chiko Otani: Terahertz Spectroscopy in Polymer
Research:

AssignmentofIntermolecularVibrational

Modes

and

Structural

Characterization of Poly(3-Hydroxybutyrate), IEEE Transactions on Terahertz Scienceand Technology, 3, 248-258 (2013)(20) Takeyoshi Goto, Yusuke Morisawa, Noboru Higashi, Akifumi Ikehata, and Yukihiro
Ozaki: Pulse Laser Photolysis of Aqueous Ozone in the Microsecond Range Studied byTime-Resolved Far-Ultraviolet Absorption Spectroscopy: Analytical Chemistry, 85, 45004506 (2013).
(21) Yeonju Park, Chihiro Hashimoto, Takeji Hashimoto, Yoshitsugu Hirokawa, Young MeeJung and Yukihiro Ozaki: Reaction-Induced Self-Assembly of Gel Structure: A New
Insight into Chemical Gelation Process of N‑Isopropylacrylamide as Studied by TwoDimensional Infrared Correlation Spectroscopy: Macromolecules, 46, 3587-3602 (2013).
(22) Tamitake Itoh, Yuko S. Yamamoto, Hiroharu Tamaru, Vasudevanpillai Biju, Norio
Murase, and Yukihiro Ozaki: Exciation laser energy dependence of surface-enhanced
fluorescence showing Plasmon-induced ultrafast electronic dynamics in dye molecules:
Physical Review B, B 87, 235408 (2013)(23) Hal Suzuki, Shinya Ishii, Harumi Sato, Shigeki Yamamoto, Yusuke Morisawa, Yukihiro
Ozaki, Tetsuji Uchiyma, Chiko Otani, Hiromichi Hoshina: Brill transition of nylon-6
characterized by low-frequency vibration through terahertz absorption spectroscopy:
Chemical Physics Letters, 575, 36-39 (2013)(24) Tamitake Itoh, Yuko S. Yamamoto, Hiroharu Tamaru, Vasudevanpillai Biju, Norio
Murase and Yukihiro Ozaki: Excitation Laser energy dependence of surface-enhanced
fluorescence showing Plasmon-induced ultrafast electronic dynamics in dye molecules:
Physical Review., B87, 235408 (2013)(25) Edyta Proniewicz, Yukihiro Ozaki, Younkyoo Kim and Leonard M. Proniewicz:
Adsorption mode of neurotensin family peptides onto a colloidal silver surface: SERS
studies: J Raman Spectrosc., 44, 355-361 (2013)(26) Takuma Genkawa, Masahiro Watari, Takashi Nishii, Masao Suzuki and Yukihiro Ozaki:
Two-Dimensional Heterospectral Correlation Analysis of Water and Liquid Oleic Acid
Using an Online Near-Infrared/Mid-Infrared Dual-Region Spectrometer: Applied
Spectroscopy, 67, 724-730 (2013)(27) Wei Ji, Lei Chen, XiangxinXue, Zhinan Guo, Zhi Yu, Bing Zhao and Yukihiro Ozaki:
Design of an anti-aggregated SERS sensing platform for metal ion detection based onbovine serum albumin-mediated metal nanoparticles: The Royal Society of Chemistry, 49,
7334-7336 (2013).
(28) Edyta Proniewicz, Natalia Piergies, Yukihiro Ozaki, Younkyoo Kim and Leonard M.

Proniewicz: Influence of Substituent Type and Position on the Adsorption Mechanism of
Phenylboronic Acids: Infrared, Raman, and Surface Enhanced Raman Spectroscopy
Studies: J. Phys. Chem., 117, 5693-5705 (2013).
(29) Daitaro Ishikawa, Kodai Murayama, Kimie Awa, Takuma Genkawa, Makoto Komiyama,
Sergei G. Kazarian and Yukihiro Ozaki: Application of a newly developed portable NIR
imaging device to monitor dissolution process of tablets: Springer, vol.405, No.29,
p.9401-9409, (2013).
(30) Xinlei Yan, Toshiaki Suzuki, Yasutaka Kitahama, Harumi Sato, Tamitake Itoh andYukihiro Ozaki: A study on the interaction of single-walled carbon nanotubes (SWCNTs)
and polystyrene (PS) at the interface in SWCNT-PS nanocomposites using tip-enhanced
Raman spectroscopy: Phys. Phys. Chem. Chem. Phys., 15, 20618-20624(2013).
(31) Daitaro Ishikawa, Shinya Fukuda, Shigenori Arimitsu, Kazuhiko Ohba, Yukihiro Ozaki
and Etsuji Ishiguro: A case study on evaluation of water contents change in leaves(Sudajii)
by using chlorophyll absorption band in the 400-1100 nm region: J. Agric.Meteorol., 69,
201-207 (2013).
(32) Daitaro Ishikawa, Takashi Nishii, Fumiaki Mizano, Harumi Sato, Sergei G. Kazarian,
Yukihiro Ozaki: Potential of a Newly Developed High- Speed Near- Infrared (NIR)
Camera (Compovision) in Polymer Industrial Analyses: Monitoring Crystallinity and
Crystal Ebolution of Polylactic Acid (PLA) and Concentration of PLA in PLA/Poly-(R)3-Hydroxybutyrate(PHB) Blends: Applied Spectroscopy, 67, 1441-1446 (2013)(33) Yuko S. Yamamoto, Katsuyuki Hasegawa, Yuuki Hasegawa, Naoshi Takahashi, Yasutaka
Kitahama, Satoshi Fukuoka, Norio Murase, Yoshinobu Baba, Yukihiro Ozaki andTamitake Itoh: Direct conversion of silver complexes to nanoscale hexagonal columns on
a copper alloy for plasmonic applications: Physical Chemistry Chemical Physics, 15,14611-14615 (2013).
(34) Daitaro Ishikawa, Takashi Nishii, Fumiaki Mizuno, Sergei G.Kazarian and Yukihiro
Ozaki: Development of a high- speed monitoring near infrared hyperspectral camera(compovision) for wide area imaging and its applications: NIR news (2013)(35) Yusuke Morisawa, Manaka Yasunaga, Ryoichi Fukuda, Masahiro Ehara and Yukihiro
Ozaki: Electronic transitions in liquid amides studied by using attenuated total reflection
far-ultraviolet spectroscopy and quantum chemical calculations: The Journal of Chemical
Physics, 139, UNSP154301 (2013).
(36) T. Suzuki, X. Yan, Y. Kitahama, H. Sato, T. Itoh, T. Miura, Y. Ozaki: Tip-Enhanced
Raman Spectroscopy Study of Local Interactions at the Interface of Styrene - Butadiene
Rubber/Multiwalled Carbon Nanotube Nanocomposites, The Journal of Physical
Chemistry, The Journal of Physical Chemistry C, 117, 1436-1440 (2013).

(37) Yujing Chen,ab Yukihiro Ozaki and Miroslaw A. Czarnecki: Molecular structure andhydrogen bonding in pure liquid ethylene glycol and ethylene glycol water mixtures
studied using NIR spectroscopy: Phys. Chem. Chem. Phys., 15, 18694-18701 (2013)(38) Caihong Zhang, Xinlei Yan, Liyuan Wang, Yasutaka Kitahama, Yukihiro Ozaki et al: The
effect of temperature on the resonance of the interband transition energy in single-walledcarbon nanotubes with excitation laser energy by Raman spectroscopy, Appl. Phys. Lett.
103, 231902 (2013)(39) D.Ishikawa, G. Hoogenboom, Y. Ozaki and E. Ishiguro: A Study on the Spectral Change
in a Chlorophyll Absorption Band Monitored During the Growth of Japanese Tea Leaves,
J. Agric Meteorol , 69(4), 255 (2013)(40) Yuko S. Yamamoto, Mitsuru Ishikawa, Yukihiro Ozaki and Tamitake Itoh: Fundamental
studies on enhancement and blinking mechanism of surface-enhanced Raman scattering(SERS) and basic applications of SERS biological sensing: Front. Phys, 9, 31-46 (2014).
(41) Atsushi Kuriyama and Yukihiro Ozaki: Assessment of Active Pharmaceutical IngredientParticle Size in Tablets by Raman Chemical Imaging Validated using Polystyrene
Microsphere Size Standards: AAPS PharmSciTech, 15, 375-387 (2014)(42) Ichiro Tanabe and Yukihiro Ozaki: Consistent changes in electronic states andphotocatalytic activities of metal (Au, Pd, Pt)-modified TiO2 studied by far-ultraviolet
spectroscopy: ChemComm., 50, 2114-2119 (2014)(43) Kimie Awa, Hideyuki Shinzawa and Yukihiro Ozaki: An Effect of Cellulose Crystallinityon
the MoistureAbsorbability of a Pharmaceutical Tablet Studied by Near-Infrared
Spectroscopy, Applied Spectroscopy, 68(6), 625 (2014)(44) Yujing Chen, Yusuke Morisawa, Yoshisuke Futami, Mirostaw A. Czarnecki, Hai-Shi Wang
and Yukihiro Ozaki: Combined IR/NIR and Density Functional Theory Calculations
Analysis of the Solvent Effects on Frequencies and Intensities of the Fundamental and
Overtones of the C O Stretching Vibrations of Acetone and 2-Hexanone, J. Phys.
Chem.,118, 2576 (2014)(45) Ichiro Tanabe, Takayuki Ryoki and Yukihiro Ozaki: Significant Enhancement of
Photocatalytic Activity of Rutile TiO2 Compared with Anatase TiO2 upon Pt
Nanoparticle Deposition Studied by Far-Ultraviolet Spectroscopy, Phys. Chem. Chem.
Phys., 16, 7749(2014)(46) Yoshisuke Futami, Yasushi Ozaki, Yoshiaki Hamada, Yukihiro Ozaki: Frequencies andabsorption intensities of the fundamental and the first overtone of NH stretchingvibrations of pyrrole– acetylene and pyrrole– ethylene complexes studied by density –functional – theory calculation, Vibrational Spectroscopy, 72, 124-127 (2014)(47) Hideki Shinzawa, MasakazuNishida, AkiraTsuge, DaitaroIshikawa, YukihiroOzaki,

Shigeaki Morita, Wataru Kanematsu:

Thermal Behavior of Poly(lactic acid)-

Nanocomposite Studied by Near-InfraredImaging Based on Roundtrip Temperature Scan,
Appl. Spectrosc. 68(3), 371 (2014)(48) Kazutoshi Sanada, Yusuke Morisawa and Yukihiro Ozaki: Environmentally friendly
synthesis and physical and optical properties of highly reflective green-black pigments, J.
Ceramic Society of Japan, 122(5), 322 (2014)(49) Binglian Bai, Jue Wei, Nicolas Spegazzini, Yuqing Wu, Haitao Wang, Min Li,Yukihiro
Ozaki: Two-dimensional correlation infrared spectroscopy studies onthe thermal-induced
mesophase of 4-nitrobenzohydrazide derivative, Vibrational Spectroscopy, 70, 115(2014)(50) Daitaro Ishikawa, Hideyuki Shinzawa, Takuma Genkawa, Sergei G. KAZARIAN, andYukihiro Ozaki: Recent Progress of Near-Infrared (NIR) Imaging-Development of Novel
Instruments and Their Applicability for Practical Situations: Analytical Sciences, 30(1),143 (2014)(51) Yue Wang, Wei Ji, Zhi Yu, Ran Li, Xu Wang, Wei Song, WeidongRuan, Bing Zhao andYukihiro Ozaki: Contribution of hydrogen bonding to charge-transfer induced surfaceenhanced Raman scattering of an intermolecular system comprising p-aminothiophenol
and benzoic acid: Phys. Chem. Chem. Phys., 16(7), 3153 (2014)(52) Yue Wang, Wei Ji, Zhi Yu, Ran Li, Xu Wang, Wei Song, Weidong Ruan, Bing Zhao andYukihiro Ozaki: Contribution of hydrogen bonding to charge-transfer induced surfaceenhanced Raman scattering of an intermolecular system comprising p-aminothiophenol
and benzoic acid: Phys. Chem. Chem. Phys., 16(7), 3153 (2014)(53) Yujing Chen, Hai-Shui Wang, Yusuke Morisawa, Yukihiro Ozaki: Concept and propertiesof an infrared hybrid single-beam spectrum and its application to eliminate solvent bands
and other background interferences, Talanta, 119, 105 (2014)(54) Yue Wang, Wei Ji, Huimin Sui, Yasutaka Kitahama, Weidong Ruan, Yukihiro Ozaki andBing Zhao: Exploring the effect of intermolecular H-bonding: A study on charge-transfer
contribution to surface-enhanced Raman scattering of p-mercaptobenzonic acid, J. Phys.
Chem., 118, 10197 (2014)(55) Ichiro Tanabe, Masatoshi Egashira, Toshiaki Suzuki, Takeyoshi Goto and Yukihiro Ozaki:
Prevention of photooxidation of deoxymyoglobin and reduced cytochrome c during
enhanced Raman measurements: SERRS with thiol-protected Ag nanoparticles and a
TERS technique, J. Phys. Chem., 118(19), 10329 (2014)(56) Shigeki Yamamoto, Tatsuya Furukawa, Petr Bour and Yukihiro Ozaki: Solvated states ofpoly-L-alanine α-helix explored by Raman optical activity, J. Phys. Chem.,118(20), 3655
(2014)

(57) Miriam Unger, Yukihiro Ozaki, Heinz W. Siesler: Variable-temperature Fouriertransform near-infrared imaging spectroscopy of the deuterium/hydrogen exchange inliquid D2O, Applied Spectroscopy, 68, 5 (2014)(58) Miriam Unger, Yukihiro Ozaki, Frank Pfeifer, Heinz W. Siesler: 2DCOS and PCMW2
analyses of FT-IR/ATR and FT-NIR spectra monitoring the deuterium/hydrogenexchange in liquid D2O, J. Molecular Structure, 1069, 258 (2014)(59) Tamitake Itoh, Yuko S Yamamoto, Hiroharu Tamaru, Vasudevanpillai Biju, Shin- ichi
Wakida and Yukihiro Ozaki: Single-molecular surface-enhanced resonance Raman
scattering as a quantitative probe of local electromagnetic field: The case of strong
coupling between plasmonic and excitonic resonance, Phys. Rev., B89, 195436 (2014)(60) Marek Wojcik, Jacek Kwiendacz, MarekBoczar, Lukasz Boda, Yukihiro Ozaki: Quantummechanical and Car-Parrinello molecular dynamics simulations of infrared spectra of
crystalline imidazole, J. Mol. Stru., 1072, 2-12 (2014)(61) Yasutaka Kitahama, Takuya Ikemachi, Toshiaki Suzuki, Takeshi Miura and Yukihiro
Ozaki: Plasmonic properties of triangle-shaped silver trimers selectively fabricated bynear-field photo-reduction using an apertured cantilever for an atomic force microscope,Chem. Commun.,50, 9693 (2014)(62) Binglian Bai, Jue Wei, Raghunatha Reddy Kummetha, Yukihiro Ozaki, Haitao Wang, Min
Li: Study of the hydrogen bonding of 1,4-bis[(3,4,5-trihexyloxyphenyl)hydrazide]
phenylene in crystalline and liquid crystalline phases using infrared, Raman, and twodimensional correlation spectroscopy, Vibrational Spectroscopy, 73, 150-157 (2014)(63) Yuho Mikami, Akifumi Ikehata, Chihiro Hashimoto, Yukihiro Ozaki: Near-Infrared (NIR)
Study of Hydrogen Bonding of Methanol Molecules in Polar and Nonpolar Solvents: An
Approach from Concentration-Dependent Molar Absorptivity, Appl. Spec., 68(10),1181-1189 (2014)(64) Toshiaki Suzuki, Tamitake Itoh, Sanpon Vantasin, Satoshi Minami, Yasunori Kutsuma,
Koji Ashida, Tada-aki Kaneko, Yusuke Morisawa, Takeshi Miura and Yukihiro Ozaki:
Tip-enhanced Raman spectroscopic measurement of stress change in the local domain of
epitaxial graphene on the carbon face of 4H-SiC(000-1), Phys. Chem. Chem. Phys., 16,
20236-20240 (2014)(65) K.Awa, H. Shinzawa and Y. Ozaki: Monitoring of recrystallisation of microcrystalline
cellulose inside pharmaceutical tablets during storage using near infrared diffuse
reflectance spectroscopy, J. Near Infrared Spec., 22, 205-210 (2014)(66) Daitaro Ishikawa, Takuma Genkawa, Kodai Murayama, Makoto Komiyama and Yukihiro
Ozaki: Feasibility study of diffuse reflectance and transmittance near infrared
spectroscopy for rapid analysis of ascorbic acid concentration in bilayer tablets using ahigh-speed polychromator-type spectrometer, J. Near Infrared Spec., 22, 189-197 (2014)(67) Atsushi Kuriyama and Yukihiro Ozaki: Assessment of Active Pharmaceutical IngredientParticle Size in Tablets by Raman Chemical Imaging Validated using Polystyrene
Microsphere Size Standards: AAPS PharmSciTech, 15(2), 375-387 (2014)(68) Yusuke Morisawa, Manaka Yasunaga, Harumi Sato, Ryoichi Fukuda, Masahiro Ehara and
Yukihiro Ozaki: Rydberg and π-π* Transitions in Film Surfaces of Various Kinds ofNylons Studied by Attenuated Total Reflection Far-Ultraviolet Spectroscopy and
Quantum Chemical Calculations: Peak Shifts in the Spectra and their Relation to Nylon
Structure and Hydrogen Bondings, J. Phys. Chem. B118, 11855-11861 (2014)(69) Yue Wang, Zhi Yu, Wei Ji, Yoshito Tanaka, Huimin Sui, Bing Zhao and Yukihiro Ozaki:
Enantioselective Discrimination of Alcohols by Hydrogen Bonding: A SERS Study,
Angew. Chem. Int. Ed., 53, 13866-13870 (2014)(70) Wei Ji, Yue Wang, Ichiro Tanabe, Xiaoxia Han, Bing Zhao and Yukihiro Ozaki:
Semiconductor-driven “turn-off” surface-enhanced Raman scattering spectroscopy:
application in selective determination of chromium (Ⅳ) in water, Chem. Sci., 6, 342(2014)(71) Yasutaka Kitahama, Masatoshi Egashira, Toshiaki Suzuki, Ichiro Tanabe and Yukihiro
Ozaki: Sensitive marker bands for the detection of spin states of heme in surfaceenhanced resonance Raman scattering spectra of metmyoglobin, Analyst, 139, 6421
(2014)(72) Mohammad Mydul Alam, Wei Ji, Hom Nath Luitel, Yukihiro Ozaki, Takanori Watari and
Kenichi Nakashima: Template free synthesis of dendritic silver nanostrustures and their
supplication in surface-enhanced Raman scattering, RSC Adv., 4, 52686 (2014)(73) Sanpon Vantasin, Ichiro Tanabe, Yoshito Tanaka, Tamitake Itoh, Toshiaki Suzuki,
Yasunori Kutsuma, Koji Ashida, Tadaaki Kaneko and Yukihiro Ozaki: Tip-Enhanced
Raman Scattering of Local Nanostructure of Epitaxial Graphene Grown on 4H-SiC, J.
Phys. Chem. C, 118, 25809 (2014)(74) Nicolas Spegazzini, Ishan Barman, Narahara Chari Dingari, Rishikesh Pandey, Jaqueline
S. Soares, Yukihiro Ozaki and Ramachandra Rao Dasari: Spectroscopic approach for
dynamic bioanalyte tracking with minimal concentration information, Scientific Reports,
1-7 (2014)(75) Shin-ichi Morita, Sota Takanezawa, Michio Hiroshima Toshiyuki Mitsui, Yukihiro Ozaki
and Yasushi Sako; Raman and Autofluorescence Spectrum Dynamics along the HRGInduced Differentation Pathway of MCF-7 Cells, Biophysical Journal, 107, 2221-2229(2014)(76) Kanet Wongravee, Harnchana Gatemala, Chuchaat Thammacharoen, Sanong Ekgasit,Sanpon Vantasin, Ichiro Tanabe and Yukihiro Ozaki; Nanoporus silver microstructure forsingle particle surface-enhanced Raman scattering Spectroscopy, RSC Adv., 5, 1391
(2014)(77) Yasutaka Kitahama, Masatoshi Egashira, Toshiaki Suzuki, Ichiro Tanabe and Yukihiro
Ozaki, Sensitive marker bands for the detection of spin states of heme in surfaceenhanced resonance Raman scattering spectra of metmyoglobin, Analyst, 139, 6421-6425(2014).
(78) Yasutaka Kitahama, Daichi Akai, Yuko S. Yamamoto, TamitakeItoh and Yukihiro Ozaki:
Different behavior of molecules in dark SERS state on colloidal Ag nanoparticles
estimated by truncated power law analysis of blinking SERS, Phys. Chem. Chem. Phys.,
DOI: 10.1039/c4cp05070c (2015)(79) Mohammad Kamal Hossain, Genin Gary Huang, Yoshita Tanaka, Tadaaki Kaneko andYukihiro Ozaki: Anisotropic gold nanoassembly: a study on polarization-dependent andpolarization-selective surface-enhanced Raman scattering, Phys. Chem. Chem. Phys., 17,4268 (2015)(80) Saetbyeol Kim, Hideyuki Shinzawa, Hoeil Chung and Yukihiro Ozaki: Measurement ofpolyethylene pellets near the glass transition temperature to enhance Raman spectral
selectivity among samples and improve accuracy for density determination, Analyst., 140,
1906-1912 (2015)(81) Daitaro Ishikawa, Daiki Furukawa, Tseng Tsai Wei, KummethaRaghunathaReddy,
AsakoMotomura, Yoko Igarashi, Harumi Sato, Sergei G. Kazarianand Yukihiro
Ozaki;High-speed monitoring of the crystallinity changein poly(lactic acid) during
photodegradation by using a newlydeveloped wide area NIR imaging system(Compovision),Anal. Bioanal. Chem., 407, 397-403 (2015)(82) Hongyue Zhao, Jing Jin, WeijunTian, Ran Li, Zhi Yu, Wei Song, Qian Cong, Bing Zhao
and Yukihiro Ozaki; Three-dimensional superhydrophobic surface-enhanced Raman
spectroscopy substrate for sensitive detection of pollutants in real environments, J. Mater.
Chem., 3, 4330-4337 (2015)(83) Kodai Murayama, Daitaro Ishikawa, Takuma Genkawa, Hiroyuki Sugino,Makoto
Komiyama and Yukihiro Ozaki;Image Monitoring of Pharmaceutical Blending Processes
and theDetermination of an End Point by Using a Portable Near-Infrared ImagingDevice
Based on a Polychromator-Type Near-Infrared Spectrometer with aHigh-speed andHigh-Resolution Photo Diode Array Detector,Molecules, 20, 4007-4019 (2015)(84) TakeyoshiGoto, AkifumiIkehata, Yusuke Morisawa and Yukihiro Ozaki;Surface effect ofalumina on the first electronic transition of liquidwater studied by far-ultraviolet
spectroscopy,J. Phys. Chem. Lett., 6, 1022-1026 (2015)

(85) Wei Ji, Wei Song, Ichiro Tanabe, Yue Wang, Bing Zhao and Yukihiro Ozaki:
Semiconductor-enhanced Raman scattering for highly robust SERS sensing: the case ofphosphate analysis, Chemical Communications, 51, 7641 - 7644 (2015).
(86) D. Ishikawa, A. Motomura, Y. Igarashi, Y. Ozaki: Near-infrared imaging using a highspeed monitoring near infrared hyperspectral camera (Compovision) Spectroscopy andSpectral Analysis, 35 (04), 865-869 (2015).
(87) T. Nishii, S. Morita, T. Genkawa, M. Watari, D. Ishikawa, Y. Ozaki, Moving-Window
Two-Dimensional Heterospectral (MW2DHetero) Correlation Analysis and Its
Application for the Process Monitoring of Alcoholic Fermentation, Applied Spectroscopy,
69, (6), 665-670 (2015).
(88) Sota Takanezawa, Shin-ichi Morita Yukihiro Ozaki and Yasushi Sako,
Raman Spectral Dynamics of Single Cells in the Early Stages of Growth Factor
Stimulation, Biophysical Journal, 108, 2148-2157(2015).
(89) Wei Song, Wei Ji, Sanpon Vantasin, Ichiro Tanabe, Bing Zhao and Yukihiro Ozaki,
Fabrication of a highly sensitive surface-enhanced Raman scattering substrate formonitoring the catalytic degradation of organic pollutants, Journal of Materials Chemistry
A, 3, 13556-13562 (2015).
(90) Tomokazu Tajiri, Shigeaki Morita, Ryosaku Sakamoto, Hisahi Mimura, Yukihiro Ozaki,
Christos Reppas, Satoshi Kitamura, Developing dissolution testing methodologies forextended-release oral dosage forms with supersaturating properties. Case example: Soliddispersion matrix of indomethacin, International Journal of Pharmaceutics, 490, 368-374(2015)(91) Mateusz Z. Brela, Marek J. Wojcik, Marek Boczar, Lukasz Witek, Mitsuru Yasuda, andYukihiro Ozaki, Car-Parrinello Molecular Dynamics Simulations of Infrared Spectra of
Crystalline Vitamin C with Analysis of Double Minimum Proton Potentials for MediumStrong

Hydrogen

Bonds,The

JournalofPhysicalChemistry

B,

DOI:

10.1021/acs.jpcb.5b02777 (2015).
(92) Kimie Awa, Hideyuki Shinzawa and Yukihiro Ozaki, "The Effect of Microcrystalline
Cellulose Crystallinity on the Hydrophilic Property of Tablets and the Hydrolysis ofAcetylsalicylic Acid as Active Pharmaceutical Ingredient Inside Tablets", AAPS
PharmSciTech, Volume 16 Number 4, 865-870 (2015).
(93) Sanpon Vantasin, Xin-lei Yan, Toshiaki Suzuki, and Yukihiro Ozaki, “Tip-Enhanced
Raman Scattering of Nanomaterials”, e-Journal of Surface Science and Nanotechnology,
13, 329-338 (2015).
(94) Khasanah, Kummetha Raghunatha Reddy, Harumi Sato, Isao Takahashi, and Yukihiro
Ozaki, “Intermolecular hydrogen bondings in the poly (3-hydroxybutyrate) and chitinblends: Their effects on the crystallization behavior and crystal structure of poly (3hydroxybutyrate”, Polymer, 75, 141-150 (2015).
(95) Yasutaka Kitahama, Daichi Araki, Yuko S. Yamamoto, Tamitake Itoh and Yukihiro Ozaki,“Different behaviour of molecules in dark SERS state on colloidal Ag nanoparticles
estimated by truncated power law analysis of blinking SERS†”, Phys.Chem.Chem.Phys.,
17, 21204-21210 (2015).
(96) T. Genkawa, T. Ahamed, R. Noguchi, T. Takigawa, and Y. Ozaki, “Simple and rapid
determination of free fatty acids in brown rice by FTIR spectroscopy in conjunction witha second-derivative treatment”, Food Chemistry, 191, 7-11, (2016)(97) I. Tanabe, D. Ishikawa, D. Furukawa, M. Ishigaki, T. Goto, T. Morishima, T. Okuno andY. Ozaki, Imaging of Hydrophilicity and its inhomogeneity on a Titanium Dioxide Film
Exposed to Ultraviolet Irradiations Using the Newly Developed Near-Infrared Camera(Compovision), Applied Spectroscopy, 69, 11, 1251-1256 (2015)(98) Sanpon Vantasin, Yoshito Tanaka, Shohei Uemura, Toshiaki Suzuki, Yasunori Kutsuma,
Daichi Doujima, Tadaaki Kaneko and Yukihiro Ozaki, Characterization of SiC-grown
epitaxial graphene Q1 Q2 microislands using tip-enhanced Raman spectroscopy, Phys.
Chem. Chem. Phys., 17, 28993-28999 (2015).
(99) D. Swiech, Y. Ozaki, Y. Kim and E. Proniewicz, Surface- and tip-enhanced Raman
scattering of bradykinin onto the colloidal suspended Ag surface, Phys. Chem. Chem.
Phys., 17, 17140—17149 (2015).
(100)

D. Swiech, I. Tanabe, S. Vantasin, D. Sobolewski, Y. Ozaki, A. Prahl,, S.

Mac´kowski and E. Proniewicz, Tip-enhanced Raman spectroscopy of bradykinin andits B2 receptor antagonists adsorbed onto colloidal suspended Ag nanowires, Phys. Chem.
Chem. Phys., 17, 22882—22892 (2015).
(101)

Wei Ji, Bing Zhao and Yukihiro Ozaki, Semiconductor materials in analyticalapplications of surface-enhanced Raman scattering, Journal of Raman Spectroscopy,47,
51-18 (2015).
(102)

Mika Ishigaki, Shoya Kawasaki, Daitaro Ishikawa, Yukihiro Ozaki, Near-Infrared

Spectroscopy and Imaging Studies of Fertilized Fish Eggs: In Vivo Monitoring of Egg
Growth at the Molecular Level, Scientific Resorts, 6, 20066, doi:10.1038/srep20066(2016).
(103)

Mika Ishigaki, Yasuhiro Maeda, Akinori Taketani, Bibin B. Andriana, Ryu Ishihara,

Kanet Wongravee, Yukihiro Ozaki, Hidetoshi Sato, Diagnosis of early-stage esophageal
cancer by Raman spectroscopy and chemometric techniques, Analyst, 141, 1027-1033(2016).
(104)

Tamitake Itoh, Yuko S. Yamamoto, Toshiaki Suzuki, Yasutaka Kitahama, andYukihiro Ozaki, Darkfield microspectroscopy of nanostructures on silver tip-enhanced
Raman scattering probes, Applied Physics Letters, 108, 021604 (2016)(105)

Yoshisuke Futami, Yasushi Ozaki, Yukihiro Ozaki, Absorption Q1 Q2 intensitychanges and frequency shifts of fundamental and first overtone bands for OH stretchingvibration of methanol upon methanol–pyridine complex formation in carbon
tetrachloride: analysis by near-infrared/infrared spectroscopy and density functional
theory calculations, Physical Chemistry Chemical Physics, 18, 5580-5586 (2016).
(106)

Harumi Sato, Mai Miyada, Shigeki Yamamoto, Kummetha Raghunatha Reddy, andYukihiro Ozaki, The C-H•••O (Ether) Hydrogen Bonding along the (110) Direction in
Polyglycolic Acid Studied by Infrared Spectroscopy, Wide-angle X-ray Diffraction,
Quantum Chemical Calculations and Natural Bond Orbital Calculations, RSC Advances,6, 16817-16823 (2016).
(107)

Yeonju Park, Chihiro Hashimoto, Yukihiro Ozaki, Young Mee Jung, Understanding

the phase transition of linear poly (N-isopropylacrylamide) gel under the heating andcooling processes, Journal of Molecular Structure, 1124, 144-150 (2016).
(108)

Ichiro Tanabe, Yosuke Yamada, Yukihiro Ozaki, Far- and Deep-UV Spectroscopy of

Semiconductor Nanoparticles Measured Based on Attenuated Total ReflectanceSpectroscopy, Chem Phys Chem, 17, 516-519 (2016).
(109)

Yoshito Okuno, Sanpon Vantasin, In-Sang Yang, Jangyup Son, Jongill Hong, Yoshito

Yannick Tanaka, Yasushi Nakata, Yukihiro Ozaki, and Nobuyuki Naka, Side-illuminatedtip-enhanced Raman study of edge phonon in graphene at the electrical breakdown limit,
Applied Physics Letters, 108, 163110 (2016); doi: 10.1063/1.4947559(110)

Xinlei Yan, Harumi Sato and Yukihiro Ozaki, Raman and tip-enhanced Raman

scattering spectroscopy studies of polymer nanocomposites, Spectroscopy of Polymer
Nanocomposites, Elsevier, 88-111（2016）.
(111)

Sanpon Vantasin, Wei Ji, Yoshito Tanaka, Yasutaka Kitahama, Mengfan Wang,

Kanet Wongravee, Harnchana Gatemala, Sanong Ekgasit, and Yukihiro Ozaki, 3D SERS
imaging using chemically-synthesized highly-symmetric nanoporous silver microparticles,
Angew. Chem. Int. Ed., 55, 8391-8395 (2016).
(112)

Krzysztof B. Bec, Yoshisuke Futami, Marek J. Wo´jcik and Yukihiro Ozaki, A Q1

Q2 spectroscopic and theoretical study in the nearinfrared region of low concentration
aliphatic alcohols, DOI: 10.1039/c6cp00924g, Phys. Chem. Chem. Phys., 18, 1366613682 (2016).
(113)

Mateusz Z. Brela, Marek J. Wójcik, Łukasz J. Witek, Marek Boczar, Ewa Wrona,

Rauzah Hashim, and Yukihiro Ozaki, Born–Oppenheimer Molecular Dynamics Study on
Proton Dynamics of Strong Hydrogen Bonds in Aspirin Crystals, with Emphasis onDifferences between Two Crystal Forms, J. Phys. Chem. B, 120, 3854-3862 (2016).
(114)

Hideyuki Shinzawa, Daitaro Ishikawa, Mika Ishigaki and Yukihiro Ozaki, Near-

infrared Imaging of Polymers; from Basic Science to Industrial Applications,
Encyclopedia of Analytical Chemistry, Online, DOI: 10.1002/9780470027318.a9275,(2016).
(115)

Wei Song, Guangdi Nie, Wei Ji, Yanzhou Jiang, Xiaofeng Lu, Bing Zhao andYukihiro Ozaki, Synthesis of bifunctional reduced graphene oxide/CuS/Au composite
nanosheets for in situ monitoring of peroxidase-like catalytic reaction by surfaceenhanced Raman spectroscopy, RSC Advances, 6, 54456-54462 (2016).
(116)

Khasanah, Kummetha Raghunatha Reddy, Shigesaburo Ogawa, Harumi Sato, Isao

Takahashi, and Yukihiro Ozaki, Evolution of Intermediate and Highly Ordered
Crystalline States under Spatial Confinement in Poly(3-hydroxybutyrate) Ultrathin Films,
Macromolecules, 49, 11, 4202-4210 (2016).
(117)

Prompong Pienpinijtham, Sanpon Vantasin, Yasutaka Kitahama, Sanong Ekgasit,

and Yukihiro Ozaki, Nanoscale pH Profile at a Solution/Solid Interface by Chemically
Modified Tip-Enhanced Raman Scattering, J. Phys. Chem. C, 120, 14663-14668 (2016).
(118)

Krzysztof Bec, Yoshisuke Futami, Marek J. Wojcik, Takahito Nakajima, and Yukihiro

Ozaki, Spectroscopic and Computational Study of Acetic Acid and Its Cyclic Dimer in the
Near-Infrared Region, J. Phys. Chem. A, 120, 6170-6183 (2016).
(119)

Krzysztof B. Beć, Justyna Grabska, Christian W. Huck, Yukihiro Ozaki, Jerzy P.

Hawranek, Computational and quantum chemical study on high-frequency dielectric
function of tert-butylmethyl ether in mid-infrared and near-infrared regions, Journal of
Molecular Liquids, 224, 1189–1198 (2016).
(120)

Ichiro Tanabe and Yukihiro Ozaki, Far- and deep-ultraviolet spectroscopic

investigations for titanium dioxide: electronic absorption, Rayleigh scattering, and Raman
spectroscopy, J. Mater. Chem. C, 4, 7706−7717 (2016)(121)

Shigesaburo Ogawa, Yukihiro Ozaki, and Isao Takahashi, Structural Insights into

Solid-to-Solid Phase Transition and Modulated Crystal Formation in Octyl-B-DGalactoside Crystals, ChemphysChem, 17, 1-6 (2016).
(122)

Yasutaka Kitahama and Yukihiro Ozaki, Surface-enhanced resonance Raman

scattering of hemoproteins and those in complicated biological systems, Analyst, 141,
5020-5036 (2016).
(123)

Ichiro Tanabe, Yuji Kurawaki, Yusuke Morisawa and Yukihiro Ozaki, Electronic

absorption spectra of imidazolium-based ionic liquids studied by far-ultraviolet
spectroscopy and quantum chemical calculations, Phys. Chem. Chem. Phys., 18, 2252622530 (2016).

(124)

Mika Ishigaki, Akihito Nakanishi, Tomohisa Hasunuma, Akihiko Kondo, Tetsu

Morishima, Toshiaki Okuno, and Yukihiro Ozaki, High-Speed Scanning for the
Quantitative

EvaluationofGlycogen

ConcentrationinBioethanol

Feedstock

Synechocystis sp. PCC6803 by a Near-Infrared Hyperspectral Imaging System with a New
Near-Infrared Spectral Camera, Applied spectroscopy, 71(3), 463-471 (2017)(125)

Katarzyna Bulat, Anna Rygula, Ewelina Szafraniec, Yukihiro Ozaki, and Malgorzata

Baranska, Live endothelial cells imaged by Scanning Near-field Optical Microscopy(SNOM): capabilities and challenges, J. Biophotonics, 10.1002/jbio.201600081 (2016).
(126)

Hirofumi Seki, Hideki Hashimoto, and Yukihiro Ozaki, Characterization of process-induced damage in Cu/low-k interconnect structure by microscopic infrared spectroscopy
with polarized infrared light, Journal of Applied Physics, 120, 095301 (2016); doi:
10.1063/1.4962005(127)

Yukihiro Ozaki, Professor Isao Noda: The truly innovative scientist and engineer,

Journal of Molecular Structure, 1124, 8-10 (2016)(128)

Yeonju Park, Chihiro Hashimoto, Yukihiro Ozaki, Young Mee Jung, Understanding

the phase transition of linear poly(N-isopropylacrylamide) gel under the heating andcooling processes, Journal of Molecular Structure, 1124, 144-150 (2016)(129)

Ichiro Tanabe, Yoshito Y. Tanaka, Takayuki Ryoki, Koji watari, Takeyoshi Goto,

Masakazu Kikawada, Wataru Inami, Yoshimasa Kawata, and Yukihiro Ozaki, Direct
optical measurements of far- and deepultraviolet surface plasmon resonance withdifferent refractive indices, Optics Express, 24, 19, 21886 (2016).
(130)

Mengfan Wang, Khasanah, Harumi Sato, Isao Takahashi, Jianming Zhang and

Yukihiro Ozaki, Higher-order structure formation of a poly(3-hydroxybutyrate) film
during solvent evaporation, RSC Adv., 6, 95021 (2016).
(131)

Mika Ishigaki, Yui Yasui, Paralee Puangchit, Shoya Kawasaki and Yukihiro Ozaki, In

Vivo Monitoring of the Growth of Fertilized Eggs of Medaka Fish (Oryzias latipes) by
Near-Infrared Spectroscopy and Near-Infrared Imaging—A Marked Change in the
Relative Content ofWeakly Hydrogen-BondedWater in Egg Yolk Just before Hatching,
Molecules, 21, 1003 (2016)(132)

Krzysztof B. Beć, Justyna Grabska, Christian W. Huck, Yukihiro Ozaki, Jerzy P.

Hawranek, Computational and quantum chemical study on high-frequency dielectric
function of tert-butylmethyl ether in mid-infrared and near-infrared regions, Journal of
Molecular Liquids, 224, 1189–1198 (2016).
(133)

Yue Wang, Zhi Yu, Xiaoxia Han, Hongyang Su, Wei Ji, Qian Cong, Bing Zhao, andYukihiro Ozaki, Charge-Transfer-Induced Enantiomer Selective Discrimination of Chiral
Alcohols by SERS, J. Phys. Chem. C, 120, 29374−29381 (2016).

(134)

Shigeki Yamamoto, Mai Miyada, Harumi Sato, Hiromichi Hoshina, and Yukihiro

Ozaki, Low-Frequency Vibrational Modes of Poly(glycolic acid) and Thermal Expansionof Crystal Lattice Assigned On the Basis of DFT-Spectral Simulation Aided with a
Fragment Method, J. Phys. Chem. B, 121, 1128−1138 (2017).
(135)

Yan Li, Ran Guo, Shengnan Liu, Anqi He, Yanan Bao, Shifu Weng, Yaping Huang,

Yizhuang Xu, Yukihiro Ozaki, Isao Noda, and Jinguang Wu, Use of CuO Particles as an
Interface in LC-FTIR Analysis, Analytical Sciences, 33, 105-110 (2017).
(136)

Krzysztof Bec, Justyna Grabska, Yukihiro Ozaki, Jerzy P. Hawranek, and Christian

Huck, Influence of Nonfundamental Modes on Midinfrared Spectra: Anharmonic DFT
Study of Aliphatic Ethers, J. Phys. Chem. A, 121, 1412-1424 (2017)(137)

Czamara, K., Majzner, K., Selmi, A., Baranska, M., Ozaki, Y., Kaczor, A.,

Unsaturated lipid bodies as a hallmark of inflammation studied by Raman 2D and 3D
microscopy, SCIENTIFIC REPORTS, 7, DOI: 10.1038/srep40889 (2017)(138)

Yusuke Morisawa, Shin Tachibana, Akifumi Ikehata,Tao Yang, Masahiro Ehara and

Yukihiro Ozaki, Changes in the Electronic States of Low-Temperature Solidn‑Tetradecane: Decrease in the HOMO−LUMO Gap, ACS Omega, 2, 618−625 (2017)
DOI: 10.1021/acsomega.6b00539(139)

Mika Ishigaki, Kosuke Hashimoto, Hidetoshi Sato, Yukihiro Ozaki, Non-destructive

monitoring of mouse embryo development and its qualitative evaluation at the molecularlevel using Raman spectroscopy, Scientific Reports | 7:43942 | DOI: 10.1038/srep43942(2017).
(140)

Xiaolei Wang, Bing Zhao, Peng Li, Xiao Xia Han, and Yukihiro Ozaki , Charge

Transfer at the TiO2/N3/Ag Interface Monitored by Surface-Enhanced Raman
Spectroscopy, J. Phys. Chem. C, 121, 5145−5153 (2017).
(141)

Justyna Grabska, Krzysztof B. Beć, Yukihiro Ozaki and Christian W. Huck,

Temperature Drift of Conformational Equilibria of Butyl Alcohols Studied by NearInfrared Spectroscopy and Fully Anharmonic DFT, J. Phys. Chem. A, 121, 1950−1961(2017).
(142)

Christian G. Kirchler, Cornelia K. Pezzei, Krzysztof B. Beć, Sophia Mayr, Mika

Ishigaki, Yukihiro Ozaki and Christian W. Huck, Critical evaluation of spectral
information of benchtop vs. portable near-infrared spectrometers: quantum chemistry
and twodimensional correlation spectroscopy for a better understanding of PLS
regression models of the rosmarinic acid content in Rosmarini folium†, Analyst, 142,
455-464 (2017).
(143)

Phiranuphon Meksiarun, Mika Ishigaki, Verena A.C. Huck-Pezzei, Christian W.

Huck, Kanet Wongravee, Hidetoshi Sato and Yukihiro Ozaki, Comparison of multivariate

analysis methods for extracting the paraffin component from the paraffinembedded
cancer tissue spectra for Raman imaging, Scientific Reports | 7:44890 | DOI:
10.1038/srep44890 (2017).
(144)

Christian W Huck, Krzysztof B Bec´, Justyna Grabska and Yukihiro Ozaki,

Quantum chemical calculation of NIR spectra of practical materials, NIR news, 28, 2, 13–
20 (2017).
(145)

Chalermpun Thamasopinkul, Pitiporn Ritthiruangdej, Sumaporn Kasemsumran,Thongchai Suwonsichon, Vichai Haruthaithanasan and Yukihiro Ozaki, Temperaturecompensation for determination of moisture and reducing sugar of longan honey by nearinfrared spectroscopy, Journal of Near Infrared Spectroscopy, 25, 1, 36–44 (2017).
(146)

Yukihiro

Ozaki,

Frontiers

of

Far-Ultraviolet

Spectroscopy

in theSolidand Liquid States, Spectroscopy, 32 (2), 40-51 (2017). Review Paper(147)

Yasutaka Kitahama, Takuji Nagahiro, Yoshito Tanaka, Tamitake Itoh and Yukihiro

Ozaki, Analysis of blinking from multicoloured SERSactive Ag colloidal nanoaggregateswith poly-L-lysine via truncated power law, Journal of Raman Spectroscopy, 48, 570–577(2017).
(148)

Xiao Xia Han, Wei Ji, Bing Zhao and Yukihiro Ozaki, Semiconductor-enhanced

Raman scattering: active nanomaterials and applications, Nanoscale, 9, 4847-4861 (2017).
Review Paper(149)

Mengfan Wang, Sanpon Vantasin, Jiping Wang, Harumi Sato, Jianming Zhang, andYukihiro Ozaki, Distribution of Polymorphic Crystals in the Ring-Banded Spherulites ofPoly(butylene adipate) Studied Using High-Resolution Raman Imaging, Macromolecules,
50 (8), 3377-3387 (2017).
(150)

Suthatta Areekij, Pitiporn Ritthiruangdej, Sumaporn Kasemsumran, Nantawan

Therdthai, Vichai Haruthaithanasan and Yukihiro Ozaki, Rapid and nondestructive
analysis of deep-fried taro chip qualities using near infrared spectroscopy, Journal of Near
Infrared Spectroscopy, 25(2), 127–137 (2017)(151)

Mateusz Z. Brela, Marek Boczar, Marek J. Wójcik, Harumi Sato, Takahito Nakajima,

Yukihiro Ozaki, The Born-Oppenheimer molecular simulations of infrared spectra of
crystalline poly-(R)-3-hydroxybutyrate with analysis of weak C-O…O=C hydrogen bonds,
Chemical Physics Letters, 678, 112–118 (2017)(152)

Justyna Grabska, Mika Ishigaki, Krzysztof B. Beć, Marek J. Wójcik, and Yukihiro

Ozaki, Correlations between Structure and Near-Infrared Spectra of Saturated andUnsaturated Carboxylic Acids. Insight from Anharmonic Density Functional Theory
Calculations, J. Phys. Chem. A, 121, 3437−3451 (2017)(153)

Justyna Grabskaa, Krzysztof B. Bec, Mika Ishigaki, Marek J. Wójcik, Yukihiro Ozaki,

Spectra-structure correlations of saturated and unsaturated medium-chain fatty acids.
Near-infrared and anharmonic DFT study of hexanoic acid and sorbic acid,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 185, 35-44 (2017)(154)

Mengfan Wang, Kohji Tashiro, and Yukihiro Ozaki, Reinvestigation of the β‑to‑αCrystal Phase Transition of Poly(butylene adipate) by the Time-Resolved X‑ray
Scattering and FTIR Spectral Measurements in the Temperature-Jump Process,Macrololecules, 50, 3883-3889 (2017)(155)

Chihiro Funaki, Takuya Toyouchi, Hiromichi Hoshina, Yukihiro Ozaki, and Harumi

Sato, Terahertz Imaging of the Distribution of Crystallinity and Crystalline Orientation
in

a

Poly

(ε-caprolactone)

Film,

AppliedSpectroscopy,

DOI:

10.1177/0003702816684838 (2017)(156)

Yasutaka Kitahama, Shohei Uemura, Ryota Katayama, Toshiaki Suzuki, Tamitake

Itoh, and Yukihiro Ozaki, Polarization dependence of tip-enhanced Raman and plasmonreseonance Rayleigh scattering spectra, Applied Physics Letters, 110(23), 233104 (2017)(157)

Hirofumi Seki, Masanobu Yoshikawa, Takuma Kobayashi, Tsunenobu Kimoto, andYukihiro Ozaki, Characterization of Thermal Oxides on 4H-SiC Epitaxial Substrates
Using Fourier-Transform Infrared Spectroscopy, Applied Spectroscopy, 71(5), 911-918(2017)(158)

Mika Ishigaki, Nakanishi, A., Hasunuma, T., Kondo, A., Morishima, T., Okuno, T.,

and Yukihiro Ozaki, High-speed scanning for the quantitative evaluation of glycogenconcentration in bioethanol feedstock synechocystis sp. PCC6803 using a near-infrared
hyperspectral imaging system with a new near-infrared spectral camera, Applied
spectroscopy, 71(3), 463-471 (2017)(159)

Tamitake Itoh, Yuko S. Yamamoto and Yukihiro Ozaki, Plasmon-enhanced

spectroscopy of absorption and spontaneous emissions explained using cavity quantum
optics, Chem Soc Rev, DOI: 10.1039/c7cs00155j (2017). Review paper(160)

Hongyue Zhao, Yue Guo, Shoujun Zhu, Yubin Song, Jing Jin, Wei Ji, Wei Song, Bing

Zhao, Bai Yang, Yukihiro Ozaki, Facile synthesis of silver nanoparticles/carbon dots for acharge transfer study and peroxidase-like catalytic monitoring by surface-enhanced
Raman scattering, Applied Surface Science, 410, 42–50 (2017).
(161)

Ichiro Tanabe, Yoshito Y. Tanaka, Koji Watari, Taras Hanulia , Takeyoshi Goto,

Wataru Inami, Yoshimasa Kawata and Yukihiro Ozaki, Far- and deep-ultraviolet surface
plasmon resonance sensors working in aqueous solutions using aluminum thin films,
Scientific Reports, 7, 5934, DOI:10.1038/s41598-017-06403-9 (2017).
(162)

Takeyoshi Goto, Krzysztof Bec, and Yukihiro Ozaki, Interpretation of the A˜ ’ X˜transition of hydrated protons in aqueous solutions observed in the far-UV region with

quantum chemical calculations†, Phys.Chem.Chem.Phys., 19, 21490 (2017).
(163)

Mika Ishigaki, Phiranuphon Meksiarun, Yasutaka Kitahama, Leilei Zhang, Hideki

Hashimoto, Takuma Genkawa, and Yukihiro Ozaki, Unveiling the Aggregation of
Lycopene in Vitro and in Vivo: UV−Vis, Resonance Raman, and Raman Imaging Studies,
J. Phys. Chem. B., 121, 8046−8057 (2017).
(164)

Shigeaki Morita, Yukihiro Ozaki, Moving-Window Two-Dimensional Correlation

Spectroscopy

andPerturbation-Correlation

Moving-Window

Two-Dimensional

Correlation Spectroscopy, Chemometrics and Intelligent Laboratory Systems, 168, 114120 (2017).
(165)

Ichiro Tanabe, Yoshito Tanaka, Koji Watari, Taras Hanulia, Takeyoshi Goto,

Wataru Inami, Yoshimasa Kawata, and Yukihiro Ozaki, Far- and deep-ultraviolet surface
plasmon resonance sensors working in aqueous solutions using aluminum thin films,
Scientific Reports, 7, 5934 (2017)(166)

Krzysztof B. Beć, Justyna Grabska and Yukihiro Ozaki, Advances in Anharmonic

Methods and Their Applications to Vibrational Spectroscopies, Frontiers of Quantum
Chemistry (in press)(167)

Yuqing Wu, Liping Zhang, Young Mee Jung, Yukihiro Ozaki, Two-dimensionalcorrelation spectroscopy in protein science, a summary for past 20 years, Spectrochim
Acta Part A: Molecular and Biomolecular Spectroscopy, 189, 291-299 (2018) Review
Paper
(168)

Anqi He, Xiaoyan Kang, Yizhuang Xu, Isao Noda, Yukihiro Ozaki, Jinguang Wu,

Investigation on intermolecular interaction between berberine and β-cyclodextrin by 2D
UV–Vis asynchronous spectra, Spectrochimica Acta Part A: Molecular and Biomolecular
Spectroscopy, 185, 343–348 (2017)(169)

Yukihiro Ozaki, Christian W. Huck and Krzysztof B. Bec, Near-IR Spectroscopy and

Its Applications, Molecular and Laser Spectroscopy Advances and Applications, Elsevier,11-38 (2017) Book Chapter(170)

Yizhuang Xu, Yukihiro Ozaki, Isao Noda and Young M. Jung, 2D Correlation

Spectroscopy and Its Application in Vibrational and Optical Spectroscopy, Molecular andLaser Spectroscopy Advances and Applications, Elsevier, 217-240 (2017) Book Chapter(171)

Anqi He, Xianzhe Zeng, Yizhuang Xu, Isao Noda, Yukihiro Ozaki and Jinguang Wu,

Investigation on the Behavior of Noise in Asynchronous Spectra in Generalized TwoDimensional (2D) Correlation Spectroscopy and Application of Butterworth Filter in the
Improvement of Signal-to-Noise Ratio of 2D Asynchronous Spectra, J. Phys. Chem. A,
121, 7524−7533 (2017).
(172)

Ichiro Tanabe, Yoshito Y. Tanaka, Koji Watari, Taras Hanulia, Takeyoshi Goto,Wataru Inami, Yoshimasa Kawata, and Yukihiro Ozaki, Aluminum Film Thickness
Dependence of Surface Plasmon Resonance in the Far- and Deep-ultraviolet Regions,Chem. Lett., 46, 1560–1563 (2017).
(173)

Yasutaka Kitahama, Hiroaki Hayashi, Tamitake Itoh and Yukihiro Ozaki,

Measurement of pH-dependent surface-enhanced hyper-Raman scattering at desired
positions on yeast cells via optical trapping, Analyst, 142, 3967-3974 (2017).
(174)

Prompong Pienpinijtham, Sanpon Vantasin, Yasutaka Kitahama, Sanong Ekgasit,

Yukihiro Ozaki, Extension of nano-scaled exploration into solution/liquid systems using
tip-enhanced Raman scattering, Proceedings of SPIE, 10350, 1035003-1-10. Proceedings(175)

Latthika Wimonsiri, Pitiporn Ritthiruangdej, Sumaporn Kasemsumran, Nantawan

Therdthai, Wasaporn Chanput and Yukihiro Ozaki, Rapid analysis of chemicalcomposition in intact and milled rice cookies using near infrared spectroscopy, Journal of
Near Infrared Spectroscopy, 25(5), 330-337 (2017)(176)

Justyna Grabska, Mirosław A. Czarnecki, Krzysztof B. Beć, and Yukihiro Ozaki,

Spectroscopic and Quantum Mechanical Calculation Study of the Effect of Isotopic
Substitution on NIR Spectra of Methanol, J. Phys. Chem. A, 121, 7925-7936 (2017)(177)

Xiaolei Wang, Peng Li, Xiao Xia Han, Yasutaka Kitahama, Bing Zhao and Yukihiro

Ozaki, An enhanced degree of charge transfer in dye-sensitized solar cells with a ZnOTiO2/N3/Ag structure as revealed by surface-enhanced Raman scattering, Nanoscale, 9,15303-17313 (2017)(178)

Khasanah, Isao Takahashi, Kummetha Raghunatha Reddy and Yukihiro Ozaki,

Crystallization of ultrathin poly(3-hydroxybutyrate) films in blends with small amounts ofpoly(L-lactic acid): correlation between film thickness and molecular weight of poly(Llactic acid), RSC Advances, 7, 52651-52660 (2017)(179)

Mika Ishigaki, Takashi Nishii, Paralee Puangchit, Yui Yasui, Christian W. Huck,

Yukihiro Ozaki, Noninvasive, high-speed, near-infrared imaging of the biomolecular
distribution and molecular mechanism of embryonic development in fertilized fish eggs,
Journal of Biophotonics, DOI: 10.1002/jbio.201700115 (2017).
(180)

Paralee Puangchit, Mika Ishigaki, Yui Yasui, Misato Kajita, Pitiporn Ritthiruangdej

and Yukihiro Ozak, Non-staining visualization of embryogenesis and energy metabolism
in medaka fish eggs using near-infrared spectroscopy and imaging, Analyst, 142, 47654772 (2017)(181)

Morihisa Terasaki, Khasanah, Yukihiro Ozaki, Isao Takahashi, Harumi Sato, Studyon phase separation in an ultra-thin poly(methyl methacrylate)/poly(4-vinyl phenol) film
by infrared reflection absorption spectroscopy, Polymer, 135, 69-75 (2017).
(182)

E. Proniewicz, S. Vantasin, T. K. Olszewski, B. Boduszek and Y. Ozaki, Biologicalapplication of water-based electrochemically synthesized CuO leaf-like arrays: SERS
response modulated by the positional isomerism and interface type, Phys. Chem. Chem.
Phys., 19, 31842-31855 (2017).
(183)

Anqi He, Yiwei Zeng, Xiaoyan Kang, Shigeaki Morita, Yizhuang Xu, Isao Noda,

Yukihiro Ozaki, Jinguang Wu; Novel Method of Constructing Two-Dimensional
Correlation Spectroscopy without Subtracting a Reference Spectrum, J. Phys. Chem. A
2018, 122, 3, 788-797.
(184)

Justyna Grabska, Krzysztof B. Beć, Mika Ishigaki, Christian W. Huck, Yukihiro

Ozaki; NIR Spectra Simulations by Anharmonic DFT-Saturated and Unsaturated LongChain Fatty Acids, J. Phys. Chem. B 2018, 122, 27, 6931-6944.
(185)

Anqi He, Yiwei Zeng, Xiaoyan Kang, Shigeaki Morita, Yizhuang Xu, Isao Noda,

Yukihiro Ozaki, and Jinguang Wu, Novel Method of Constructing Two-Dimensional
Correlation Spectroscopy without Subtracting a Reference Spectrum, J. Phys. Chem. A,
122, 788−797 (2018)(186)

Mateusz Brela, Marek J. Wojcik, Marek Boczar, Erika Onishi, Harumi Sato, Takahito

Nakajima, Yukihiro Ozaki, Study of hydrogen bond dynamics in Nylon 6 crystals using IR
spectroscopy and molecular dynamics focusing on the differences between a and c crystal
forms, Quantum Chemistry, DOI: 10.1002/qua.25595 (2018).
(187)

Chihiro Funaki, Shigeki Yamamoto, Hiromichi Hoshina, Yukihiro Ozaki, Harumi

Sato, Three different kinds of weak C-H/O¼C inter- and intramolecular interactions inpoly(ε-caprolactone) studied by using terahertz spectroscopy, infrared spectroscopy andquantum chemical calculations, Polymer, 137, 245-254 (2018)(188)

Krzysztof B. Bec´, Yusuke Morisawa, Kenta Kobashi, Justyna Grabska, Ichiro

Tanabe, Erika Tanimura, Harumi Sato, Marek J. Wo´jcik and Yukihiro Ozaki, Rydbergtransitions as a probe for structural changes and phase transition at polymer surfaces: an
ATR-FUV-DUV and quantum chemical study of poly(3-hydroxybutyrate) and its
nanocomposite with graphene, Phys. Chem. Chem. Phys., 2018, 20, 8859—8873 (2018).
(189)

Ewelina Wiercigroch, Emilia Staniszewska-Slezak, Kinga Szkaradek, Tomasz Wojcik,

Yukihiro Ozaki,Malgorzata Baranska, and Kamilla Malek, FT-IR Spectroscopic Imaging
of Endothelial Cells Response to Tumor Necrosis Factor-α: To Follow Markers ofInflammation Using Standard and High-Magnification Resolution, Anal. Chem., 90,3727–3736 (2018).
(190)

Xiaolei Wang, Xiao Xia Han, Hao Ma, Peng Li, Xueliang Li, Yasutaka Kitahama,

Bing Zhao, Yukihiro Ozaki; Reduced Charge-Transfer Threshold in Dye-Sensitized Solar
Cells with an Au@Ag/N3/n-TiO2 Structure As Revealed by Surface-Enhanced Raman
Scattering, J. Phys. Chem. C 2018, 122, 24, 12748-12760.

(191)

Yasutaka Kitahama, Yumi Nishiyama, Yukihiro Ozaki; Blinking Surface-Enhanced

Raman Scattering and Fluorescence From a Single Silver Nanoaggregate Simultaneously
Analyzed by Bi-Color Intensity Ratios and a Truncated Power Law, J. Phys. Chem. C
2018, 122, 38, 22106-22113.
(192)

Mika Ishigaki, Paralee Puangchit, Yui Yasui, Akane Ishida, Hiroki Hayashi,

Yoshihiko Nakayama, Hideya Taniguchi, Ichiro Ishimaru, Yukihiro Ozaki; Nonstaining
Blood Flow Imaging Using Optical Interference Due to Doppler Shift and Near-Infrared
Imaging of Molecular Distribution in Developing Fish Egg Embryos, Anal. Chem. 2018,90, 8, 5217-5223.
(193)

Haijing Zhang, Yiming Kou, Junbo Li, Lei Chen, Zhu Mao, Xiao Xia Han, Bing Zhao,

Yukihiro Ozaki; Nickel Nanowires Combined with

Surface-Enhanced Raman

Spectroscopy: Application in Label-Free Detection of Cytochrome c‐MediatedApoptosis, Anal. Chem. (2019) 91, 1213-1216.
(194)

Y. Kitahama, M. Funaoka, and Y. Ozaki: "Plasmon-enhanced optical tweezers for

single molecule on and near a colloidal silver nanoaggregate", J. Phys. Chem. C, 123,
18001-18006 (2019).
(195)

Krzysztof Bernard Beć, Daniel Karczmit, Michał Kwaśniewicz, Yukihiro Ozaki,

Mirosław Antoni Czarnecki; Overtones of νC≡N Vibration as a Probe of Structure of
Liquid CH 3 CN, CD 3 CN, and CCl 3 CN: Combined Infrared, Near-Infrared, and Raman
Spectroscopic Studies with Anharmonic Density Functional Theory Calculations, J. Phys.
Chem. A 2019, 123, 20, 4431-4442.
(196)

Yue Wang, Jing Liu, Yukihiro Ozaki, Zhangrun Xu and Bing Zhao: "Effect of TiO2

on Altering Direction of Interfacial Charge Transfer in a TiO2-Ag-MPY-FePc System by
SERS", Angewandte Chemie Int. Ed. 58, 8172 (2019).
(197)

Ran Guo, Xin Zhang, An-Qi He, Fei Zhang, Qing-Bo Li, Zhuo-Yong Zhang, Roma

Tauler, Zhen-Qiang Yu, Shigeaki Morita, Yi-Zhuang Xu, Isao Noda, Yukihiro Ozaki, JinGuang Wu: "A nove; systematic absence of cross peaks-based 2D-COS approach forbilinear data" Spectrochim. Acta 220, 117103 (2019).
(198)

Shigeki Yamamoto, Erika Ohnishi, Harumi Sato, Hiromichi Hoshina, Daitarou

Ishikawa, Yukihiro Ozaki: "Low-Frequency Vibrational Modes of Nylon 6 Studied byUsing Infrared and Raman Spectroscopies and DFT Calculations"J. Phys. Chem. B,

123, 5368 (2019).
(199)

Jian Hu, Jiping Wang, Mengfan Wang, Yukihiro Ozaki, Harumi Sato, and Jianming

Zhang:"Investigation of crystallization behavior of asymmetric PLLA/PDLA blend"
Polymer, 172,1 (2019).
(200)

J. Grabska, K. Bec, C. Kirchler, Y, Ozaki, and C. Huck; "Distinct difference insensitivity of NIR vs. IR bands of melamine to inter-molecular intereaction with impact
on analytical spectroscopy explained by anharmonic quantum mechanical study" 、
Molecules, 24、1402（2019).
(201)

S. Delueg, C. Kirchler, F. Meischl, Y. Ozaki, M. A. Popp, G. K. Bonn and C. W.

Huch; At-Line Monitoring of the Extraction Process of Rosmarini Folium via Wet
Chemical Assays, UHPLC Analysis, and Newly Developed Near-Infrared Spectroscopic
Analysis Methods, Molecules, 24, 2480 (2019)(202)

Y. Wang, J. Liu, X. Zhao, C. Yang, Y. Ozaki, Z. Xu, B. Zhao, Z. Yu; A chiralsugnal^amplified sensor for enantioselective discrimination of amino acds based on
charge transfer-induced SERS, Chem. Commun., 2019,55, 9697-9700.
(203)

X. Yue, Y. Su, X. Wang, L. Li, W. Ji, Y. Ozaki; Reusable Silicon-Based SERS Chip

for Ratiometric Analysis of Fluoride Ion in Aqueous Solutions, ACS Sens. 2019, 4, 23362342.
(204)

E. Proniewicz, A. Tata, A. Szkudlarek, J. Swider, M. Molenda, M. Starowicz, Y.

Ozaki;, Electrochemically synthesized γ-Fe2O3 nanoparticles as peptide carriers andsensitive and reproducible SERS biosensors. Comparison of adsorption on versus Fe. Appl.
Surf. Sci. 2019, 495, 143578.
(205)

L. Li, W. Song, W. Ji, X. Wang, B. Zhao, Y. Ozaki; Enhanced Raman Scattering by

ZnO Superstructures: Synergistic Effect of Mie Resonance and Charge-Transfer, Angew.
Chem. Int. Ed., 2019, 58, 14452-14456.
(206)

D. Marlina, H. Hoshina, Y. Ozaki, H. Sato1; Crystallization of Poly(3-hydroxybutyrate) / Poly(4-vinylphenol) Polymer Blends Studied by Low-Frequency
Vibrational Spectroscopy, Polymer, 2019, 181, 121790.
(207)

D. Ishikawa, K. Murayama, T. Genkawa, Y. Kitagawa, Y. Ozaki; A new identification

method for defective tablets by distribution analysis of NIR imaging, J. Spect. Imag., 2019,8, a15.
(208)

Q. Chen, Y. Zhang, Y. Guo, Y. Cheng, H. Qian, W. Yao, Y. Xie, Y. Ozaki; Non-destructive prediction of texture of frozen/thaw raw beef by Raman spectroscopy, J. Food
Eng. 2020, 266, 109693.
(209)

X. Li, Y. Zeng, G. Deng, Y. Xu, Y. Ozaki, I. Noda, J. Wu; A novel approach on two-

dimensional correlation spectroscopy to determine the stoichiometric ratio of two
substances invoved in intermolecular interactions, Appl. Spectrosc. 2019, 73, 1051-1060.
(210)

X. Zhang, A.-Q. He, F. Zhang, Q.-B. Li, Z.-Y. Zhang, R. Tauler, Z.-Q, Yu, S. Morita,

Y.-Z. Xu, I. Noda, Y. Ozaki, I. Noda, J. Wu; A novel systematic absence of cross peakbased 2D-COD approach for bilinear data. Spectrochim. Acta, 2019, 220, 117103.
(211)

Krzysztof B. Beć, Justyna Grabska, Mirosław A. Czarnecki, Christian W. Huck,

Marek J. Wójcik, Takahito Nakajima, Yukihiro Ozaki;
IR Spectra of Crystalline Nucleobases: Combination of Periodic Harmonic Calculations
with Anharmonic Corrections Based on Finite Models, J. Phys. Chem. B 2019, 123, 47,
10001-10013.
(212)

Judith Langer, Dorleta Jimenez de Aberasturi, Javier Aizpurua, Ramon A. Alvarez-

Puebla, Baptiste Auguié, Jeremy J. Baumberg, Guillermo C. Bazan, Steven E. J. Bell, Anja
Boisen, Alexandre G. Brolo, Jaebum Choo, Dana Cialla-May, Volker Deckert, Laura
Fabris, Karen Faulds, F. Javier García de Abajo, Royston Goodacre, Duncan Graham,
Amanda J. Haes, Christy L. Haynes, Christian Huck, Tamitake Itoh, Mikael Käll, Janina
Kneipp, Nicholas A. Kotov, Hua Kuang, Eric C. Le Ru, Hiang Kwee Lee, Jian-Feng Li,
Xing Yi Ling, Stefan A. Maier, Thomas Mayerhöfer, Martin Moskovits, Kei Murakoshi,
Jwa-Min Nam, Shuming Nie, Yukihiro Ozaki, Isabel Pastoriza-Santos, Jorge Perez-Juste,
Juergen Popp, Annemarie Pucci, Stephanie Reich, Bin Ren, George C. Schatz, Timur
Shegai, Sebastian Schlücker, Li-Lin Tay, K. George Thomas, Zhong-Qun Tian, Richard
P. Van Duyne, Tuan Vo-Dinh, Yue Wang, Katherine A. Willets, Chuanlai Xu, Hongxing
Xu, Yikai Xu, Yuko S. Yamamoto, Bing Zhao, Luis M. Liz-Marzán; Present and Future ofSurface-Enhanced Raman Scattering,
ACS Nano 2019, https://doi.org/10.1021/acsnano.9b04224(213)

Ran Guo, Xin Zhang, An-Qi He, Zhen-Qiang Yu, Xiao-Feng Ling, Yi-Zhuang Xu,

Isao Noda, Yukihiro Ozaki, Jin-Guang Wu; Sample–Sample Correlation AsynchronousSpectroscopic Method Coupled with Multivariate Curve Resolution-Alternating Least
SquaresTo

Analyze

Challenging

doi.org/10.1021/acs.analchem.9b04730.

Bilinear

Data,

Anal.

Chem.

2019,