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Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024
Date of issue for the 1st edition : 08/Jul/2022
Date of revision : 05/Jul/2024

Safety Data Sheet

Section 1. Identification of the substance/mixture and of the company/undertaking
Product identifier:Product name: Phenolphthalein ethanol(90) solution (1g/L)
Reference number(SDS):96704jis_J_E2-2
Product type：
Reagent
Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses of the product: For titration
Uses advised against: Do not use for other purposes.
Details of the supplier of the safety data sheet
Manufacturer/Supplier: JUNSEI CHEMICAL CO., LTD.
Address: 1-6, Ohmano-cho, Koshigaya-shi, Saitama 343-0844, Japan
Division: Quality Assurance Department
Telephone number: +81-48-986-6161
FAX: +81-48-989-2787
e-mail address: shiyaku-t@junsei.co.jp

Section 2. Hazards identification
GHS classification and label elements of the product
Classification of the substance or mixture
PHYSICAL AND CHEMICAL HAZARDS
Flammable liquids: Category 2
HEALTH HAZARDS
Serious eye damage/eye irritation: Category 2B
Carcinogenicity: Category 1A
Reproductive toxicity: Category 1ASpecific target organ toxicity - single exposure: Category 3 (Respiratory tract irritation)
Specific target organ toxicity - single exposure: Category 3 (Narcotic effects)
Specific target organ toxicity - repeated exposure: Category 1 (liver)
Specific target organ toxicity - repeated exposure: Category 2 (central nervous system)(Note) GHS classification without description: Not classified/Classification not possible
Label elements

Signal word: Danger
HAZARD STATEMENT
H225-Highly flammable liquid and vapor
H320-Causes eye irritation
H350-May cause cancer
H360-May damage fertility or the unborn child
H335-May cause respiratory irritation
H336-May cause drowsiness or dizzinessH372-Causes damage to organs through prolonged or repeated exposure
H373-May cause damage to organs through prolonged or repeated exposure2/12
Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024
PRECAUTIONARY STATEMENT
Prevention
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Keep container tightly closed.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use non-sparking tools.
Take action to prevent static discharges.
Do not breathe dust/fume/gas/mist/vapors/spray.
Use only outdoors or in a well-ventilated area.
Wash contaminated parts thoroughly after handling.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
Do not eat, drink or smoke when using this product.
Response
In case of fire: Use water mist, alcohol-resistant foam, dry powder, CO2 to extinguish.
Get medical advice/attention if you feel unwell.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF INHALED: Remove person to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
Storage
Store in a well-ventilated place. Keep container tightly closed.
Keep cool.
Store locked up.
Disposal
Dispose of contents/container in accordance with local/national regulation.
Specific Physical and Chemical hazards
Highly flammable liquid. Vapor/air mixture may explode.

Section 3. Composition/information on ingredients
Mixture/Substance selection:
MixtureIngredient name:Phenolphthalein
Content (%):ca. 0.1
Chemical formula:C20H14O4
Chemicals No, Japan:9-1152
CAS No.:77-09-8
MW:318.33
EC No.:201-004-7
Ingredient name:Ethanol
Content (%):ca. 85.7
Chemical formula:C2H5OH
Chemicals No, Japan:2-202
CAS No.:64-17-5
MW:46.07
EC No.:200-578-6

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Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024
Ingredient name:Water
Content (%):Residual quantity of the ingredient mentioned above.
Chemical formula:H2O
CAS No.:7732-18-5
MW:18.02
EC No.:231-791-2
Note : The figures shown above are not the specifications of the product.
Components contributing to the hazard
Carcinogenic (Article 57a) in REACH SVHC candidate list
Phenolphthalein

Section 4. First-aid measures
Descriptions of first-aid measures
General measures
Get medical advice/attention if you feel unwell.
Keep victim warm and quiet.
Call emergency medical service.
IF INHALED
Remove person to fresh air and keep comfortable for breathing.
Give artificial respiration if victim is not breathing.
Administer oxygen if breathing is difficult.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF ON SKIN (or hair）
Take off immediately all contaminated clothing. Rinse skin with water or shower.
If skin irritation or rash occurs: Get medical advice/attention.
Remove and isolate contaminated clothing and shoes.
In case of burns, immediately cool affected skin for as long as possible with chilled water.
Do not remove clothing if adhering to skin.
IF IN EYES
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED
Rinse mouth.
Call a POISON CENTER/doctor/physician if you feel unwell.
Most important symptoms and effects, both acute and delayedSpecific information on symptom and effect are unknown.
Indication of any immediate medical attention and special treatment needed
Ensure that medical personnel are aware of the material(s) involved, and take precautions
to protect themselves.

Section 5. Fire-fighting measures
Extinguishing media
Suitable extinguishing media
In case of fire, use water mist, alcohol-resistant foam, dry powder, CO2 to extinguish.
Unsuitable extinguishing media
Unsuitable extinguishing media data is not available.
Specific hazards arising from the substance or mixture
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may cause pollution.

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Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024
Advice for firefighters
Specific fire-fighting measures
Evacuate non-essential personnel to safe area.
Cool container with water spray.
Special protective equipment and precautions for fire-fighters
Wear fire resistant or flame retardant clothing.
Wear protective gloves/protective clothing/eye protection/face protection.
Firefighters should wear self-contained breathing apparatus with a full facepiece operated
in the positive pressure mode.

Section 6. Accidental release measures
Personnel precautions, protective equipment and emergency procedures
Keep unauthorized personnel away.
In case of contact with substance, immediately flush skin or eyes with running water for atleast 20 minutes.
Ventilate area until material pick up is complete.
Wear proper protective equipment.
PUBLIC SAFTY: Ventilate closed spaces before entering.
Do not touch or walk through spilled material.
Environmental precautions
Runoff to sewer may create fire or explosion hazard.
Vapor explosion hazard indoors, outdoors or in sewers.
Avoid release to headsprings, rivers, lakes, ocean and groundwater.
Methods and materials for containment and cleaning up
Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
Use clean non-sparking tools to collect absorbed material.
All equipment used when handling the product must be grounded.
Preventive measures for secondary accident
Collect spillage.
Stop leak if you can do it without risk.
ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
Prevent entry into waterways, sewers, basements or confined areas.
Keep out of low areas.

Section 7. Handling and storage
Precautions for safe handling
Preventive measures(Exposure Control for handling personnel)
Do not breathe dust/fume/gas/mist/vapors/spray.
(Protective measures against fire and explosion)
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No
smoking.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use non-sparking tools.
Take action to prevent static discharges.
(Exhaust/ventilator)
Exhaust/ventilator should be available.
(Safety treatments)
Avoid contact with skin.
Avoid contact with eyes.

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Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024
Safety Measures
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
When using do not eat, drink or smoke.
Any incompatibilities
Strong oxidizing agents should not be mixed with the chemicals.
Advice on general occupational hygiene
Wash contaminated parts thoroughly after handling.
Do not eat, drink or smoke when using this product.
Storage
Conditions for safe storage
Store in a well-ventilated place. Keep container tightly closed.
Keep cool. Protect from sunlight.
Store in accordance with local/national regulation.
Store locked up.
Container and packaging materials for safe handling data is not available.
Specific end use(s)See information in Section 7.1 and 7.2 for handling and storage recommendations. See
Section 8 for exposure controls and personal protection recommendations.

Section 8. Exposure controls/personal protection
Control parameters
Control value and concentration standard value are not available in ISHA.
Adopted value(Ethanol)
Adopted value in JSOH is not available.
ACGIH(2009) STEL: 1000ppm (URT irr)
Exposure controls
Appropriate engineering controls
Do not use in areas without adequate ventilation.
Eye wash station should be available.
Washing facilities should be available.
Individual protection measures
Respiratory protection
Select and wear respiratory protection in accordance with approved standards (e.g. JIS T8150).
Recommended respiratory protection：Gas mask
Hand protection
Wear protective gloves. Recommended material(s): butyl rubber, viton
Inspect before use and replace worn or damaged gloves.
Contact the glove manufacturer for specific advice on glove selection and breakthroughtimes for your use conditions.
Chemical-resistant, impervious gloves complying with an approved standard (e.g. JIS T8116)
should be used.
Eye protection
Wear safety glasses with side-shields.
Wear eye/face protection in accordance with approved standards (e.g. JIS T8147).
Skin and body protection
Wear impervious clothing and boots in case of repeated or prolonged treatment.
Personal protective equipment for the body and skin should be selected based on the task
being performed and the risks involved.

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Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024

Section 9. Physical and Chemical Properties
Information on basic physical and chemical properties
Physical state: Liquid
Color: Colorless
Odor: Characteristic odor
Odor threshold data is not available.
Melting point/Freezing point data is not available.
Boiling point or initial boiling point: 78℃(Ethanol)
Boiling range data is not available.
Flammability (gases, liquids and solids): Ignitable
Lower and upper explosion limit/flammability limit data is not available.
Flash point: 12℃(Ethanol)
Auto-ignition temperature: 400℃(Ethanol)
Decomposition temperature data is not available.
Self-Accelerating Decomposition Temperature/SADT data is not available.
pH data is not available.
Dynamic viscosity data is not available.
Kinematic viscosity data is not available.
Solubility:
Solubility in water: Soluble
Solubility in solvent data is not available.
n-Octanol/water partition coefficient data is not available.
Vapor pressure data is not available.
Density and/or relative density data is not available.
Relative vapor density (Air=1) data is not available.
Relative density of the Vapor/air - mixture at 20℃ (Air = 1) data is not available.
Particle characteristics data is not available.
Other information
Critical temperature data is not available.
Evaporation rate data is not available.
VOC data is not available.

Section 10. Stability and Reactivity
Reactivity
Reactivity data is not available.
Chemical stability
Stable under normal storage/handling conditions.
Possibility of hazardous reactions
Possibility of hazardous reactions data is not available.
Conditions to avoid
Contact with incompatible materials.
Open flames. Heating. Sparks.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Carbon oxides

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Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024
Section 11. Toxicological Information
The product has not been subjected to toxicological testing. Refer to the available data on
the constituents.
Information on toxicological effects
Acute toxicity
Acute toxicity (Oral)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Acute toxicity (Dermal)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Acute toxicity (Inhalation)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Irritant properties
Skin corrosion/irritation[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Serious eye damage/irritation[Product]Category 2B, Causes eye irritation[Data for components of the product][GHS Cat. Japan, base data](Ethanol)rabbit : Corneal opacity, iritis, conjunctival redness and chemosis recover within 7 days.
(ECETOC TR No.48(2), 1998 et al.)Sensitization
Respiratory sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Skin sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Germ cell mutagenicity[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Carcinogenicity[Product]Category 1A, May cause cancer

8/12
Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024[Data for components of the product][GHS Cat. Japan, base data](Phenolphthalein)cat.2; IARC Gr, 2B (IARC 76, 2000 et al.)(Ethanol)cat.1A; (IARC, 2010)[IARC](Phenolphthalein)
Group 2B : Possibly carcinogenic to humans(Ethanol)Group 1 : Carcinogenic to humans[ACGIH](Ethanol)A3(2009) : Confirmed Animal Carcinogen with Unknown Relevance to Humans[NTP](Phenolphthalein)
RAHC : Reasonably Anticipated to be Human Carcinogens[EU](Phenolphthalein)
Category 1B; Substances presumed to have carcinogenic potential for humans
Reproductive toxicity[Product]Category 1A, May damage fertility or the unborn child[Data for components of the product][GHS Cat. Japan, base data](Phenolphthalein)cat. 1B; mouse : IARC 76, 2000
(Ethanol)cat. 1A; human : PATTY 6th, 2012
Specific target organ toxicity (STOT)
STOT-single exposure[Product]Category 3, May cause respiratory irritation
Category 3, May cause drowsiness or dizziness[Data for components of the product][cat.3 (respiratory tract irritation)][GHS Cat. Japan, base data](Ethanol)
respiratory tract irritation (PATTY 6th, 2012)[cat.3 (narcotic effects)][GHS Cat. Japan, base data](Ethanol)narcotic effect (PATTY 6th, 2012; SIDS, 2005)
STOT-repeated exposure[Product]Category 1, Causes damage to organs through prolonged or repeated exposure
Category 2, May cause damage to organs through prolonged or repeated exposure[Data for components of the product][cat.1][GHS Cat. Japan, base data](Ethanol)liver (DFGOT vol.12, 1999)

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Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024[cat.2][GHS Cat. Japan, base data](Ethanol)central nervous system (HSDB, Access on Jun. 2013)
Aspiration hazard[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.

Section 12. Ecological Information
The product has not been subjected to ecotoxicological testing. Refer to the available dataon the constituents.
Toxicity
Aquatic toxicity[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
Hazardous to the aquatic environment, short-term (acute)[GHS Cat. Japan, base data](Ethanol)Algae (Chlorella) EC50=1000mg/L/96hr (SIDS, 2005)
Hazardous to the aquatic environment, long-term (chronic)[GHS Cat. Japan, base data](Ethanol)
Crustacea (Ceriodaphnia sp.) NOEC=9.6mg/L/10days (SIDS, 2005)
Water solubility[Data for components of the product](Ethanol)miscible (ICSC, 2018)
Persistence and degradability[Data for components of the product](Ethanol)
Rapidly degradable (BOD_Degradation : 89% (METI existing chemical safety inspections, 1993))
Bioaccumulative potential[Data for components of the product](Ethanol)log Pow=-0.32 (ICSC, 2018)
Mobility in soil
Mobility in soil data is not available.
Other adverse effects
Ozone depleting chemical data is not available.

Section 13. Disposal considerations
Description of waste residues and information on their safe handling and methods of disposal,
including the disposal of any contaminated packaging
Waste treatment methods
Dispose of contents/container in accordance with local/national regulation.

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Phenolphthalein ethanol(90) solution (1g/L),
JUNSEI CHEMICAL CO., LTD.,96704jis_J_E2-2,05/Jul/2024
Section 14. Transport Information
UN No., UN CLASS
UN Number or ID Number : 1170
UN Proper Shipping Name :ETHANOL (ETHYL ALCOHOL) or ETHANOL SOLUTION (ETHYL ALCOHOL SOLUTION)Class or division (Transport hazard class) : 3
Packing group : II
ERG GUIDE No.: 127
IMDG Code (International Maritime Dangerous Goods Regulations)
UN Number or ID Number : 1170
UN Proper Shipping Name :ETHANOL (ETHYL ALCOHOL) or ETHANOL SOLUTION (ETHYL ALCOHOL SOLUTION)Class or division (Transport hazard class) : 3
Packing group : II
IATA (Dangerous Goods Regulations)
UN Number or ID Number : 1170
UN Proper Shipping Name :ETHANOL (ETHYL ALCOHOL) or ETHANOL SOLUTION (ETHYL ALCOHOL SOLUTION)Class or division (Transport hazard class) : 3
Hazard labels : Flamm.liquid
Packing group : II
Environmental hazards
Marine pollutants (yes/no) : noTransport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Noxious Liquid Substances ; Cat. Z
Ethanol
Non Noxious Liquid Substances ; Cat. OS
Water
MARPOL Annex V - HME (Harmful to the Marine Environment)
Carcinogenicity: cat.1, 1A, 1B
Ethanol
Reproductive toxicity: cat.1, 1A, 1B
Phenolphthalein; Ethanol
Specific target organ toxicity - repeated exposure: cat.1
Ethanol

Section 15. Regulatory Information
Safety, health and environmental regulations/legislation specific for the substance or mixture
List of substances subject to authorisation (REACH, Annex XIV)/SVHC - candidate list
Carcinogenic (Article 57a)
Phenolphthalein
U.S. Toxic Substances Control Act (TSCA) Inventory
Chemicals listed in TSCA Inventory64-17-5; 77-09-8; 7732-18-5
All components are listed or exempted.
Superfund Amendments and Reauthorizations Act (SARA), Title III
SARA 313 (TRI)
Phenolphthalein
Other regulatory information
We are not able to check up the regulatory information with regard to the substances inyour country or region, therefore, we request this matter would be filled by yourresponsibility.

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Phenolphthalein ethanol(90) solution (1g/L),
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Regulatory information with regard to this substance in your country or in your region
should be examined by your own responsibility.
Ensure this material in compliance with federal requirements and ensure conformity to local
regulations.
Regulatory information in this section are limited to intentional ingredient(s), but does
not contain information on non-intentional ingredients or impurities which are not informedby supplier(s).
Chemical safety assessment
Advice on safe handling for this product can be found in sections 7 and 8 of this SDS.

Section 16. Other information
GHS classification and labelling
H225-Flammable liquids, Category 2: H225 Highly flammable liquid and vapour
H320-Serious eye damage/eye irritation, Category 2B: H320 Causes eye irritation
H350-Carcinogenicity, Category 1A: H350 May cause cancer
H360-Reproductive toxicity, Category 1A: H360 May damage fertility or the unborn child
H335-STOT - single exposure, Category 3, Respiratory tract irritation: H335 May cause
respiratory irritation.
H336-STOT - single exposure, Category 3, Narcotic effects: H336 May cause drowsiness or dizziness.
H372-STOT - Repeated exposure, Category 1: H372 Causes damage to organs through prolonged
or repeated exposure
H373-STOT - Repeated exposure, Category 2: H373 May cause damage to organs throughprolonged or repeated exposure
References and sources for data
Globally Harmonized System of classification and labelling of chemicals, UN
Recommendations on the TRANSPORT OF DANGEROUS GOODS 22nd edit., 2021 UN
IMDG Code, 2022 Edition (Incorporating Amendment 41-22)
IATA Dangerous Goods Regulations (65th Edition) 20242020 EMERGENCY RESPONSE GUIDEBOOK (US DOT)
2024 TLVs and BEIs. (ACGIH)
JIS Z 7252 : 2019
JIS Z 7253 : 20192023 Recommendation on TLVs (JSOH)
Notification No. 0111-1 (January 11, 2022), Chemical Hazards Control Division, Industrial
Safety and Health Department, Labour Standards Bureau, MHLW in Japan
Supplier's data/information
Chemicals safety data management system "GHS Assistant" Version 4.29 (https://www.asahi-ghs.com/)
NITE Chemical Risk Information Platform "NITE-CHRIP"(https://www.chem-info.nite.go.jp/chem/chrip/chrip_search/systemTop)
GHS Classification Guidance for Enterprises 2019 Revised Edition (Ver. 2.1) （May. 2024, METI)
Abbreviations and acronyms
SDS (Safety Data Sheet)
LD50 (Lethal Dose, 50％)
LC50 (Lethal Concentration, 50％)
IARC (International Agency for Research on Cancer)
ACGIH (American Conference of Governmental Industrial Hygienists)
EPA (US Environmental Protection Agency)
NTP (US National Toxicology Program)
METI (Ministry of Economy, Trade and Industry in Japan)
MHLW (Ministry of Health, Labour and Welfare in Japan)
MOE (Ministry of the Environment in Japan)
JSOH (Japan Society for Occupational Health)
ISHA (Industrial Safety and Health Act in Japan)

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Phenolphthalein ethanol(90) solution (1g/L),
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CSCL (Chemical Substances Control Law in Japan)
EU (European Union)
EC50 (Effective Concentration, 50％)
NOEC (No Observed Effect Concentration)
BOD (Biochemical Oxygen Demand)
COD (Chemical Oxygen Demand)
BCF (Bioconcentration Factor)anh (anhydride)
General Disclaimer
This data sheet was created based on the information we currently have and may be revised
according to new information. In addition, the precautions apply only to normal handling,
and in the case of special handling, please make adequate countermeasure to maintain yoursafety.
The data given here is based on current knowledge and experience. The purpose of this
Safety Data Sheet is to describe the products in terms of their safety requirements. The
data does not signify any warranty with regard to the products' properties.
The GHS classification data given here is based on current Japan official data (NITE
published in 2022).