CellAppendix:TERMS and CONDITIONS
2013.12.02

Mouse iPS : APS0006 iPS- Stm-FB/gfp-99-3
The RECIPIENT belongs to a not-for-profit academic organization (i.e., a university or another institution of higher
education or any nonprofit scientific or educational organization, including government agencies).
(2) The RECIPIENT recognizes and acknowledges that KYOTO UNIVERSITY retains the ownership ofBIOLOGICAL RESOURCE (hereinafter referred as the “ORIGINAL CELL”) and any cell reproduced orpropagated directly or indirectly from the ORIGINAL CELL regardless of maintaining identity with theORIGINAL CELL (hereinafter referred as the “CELL”).
(3) The RECIPIENT recognizes and acknowledges that the ORIGINAL CELL was created by the scientist at KYOTO
UNIVERSITY from Nanog-IRES-Puro mouse by utilizing the Red/ET Recombineering technology of Gene
Bridges GmBH.
(4) The RECIPIENT agrees that the ORIGINAL CELL, CELL and any cell differentiated from the ORIGINAL CELL
or CELL, or any cell obtained in the course of differentiation from the ORIGINAL CELL or CELL :(a) will not be used to create admixed embryos with embryos of human; and(b) will not be used in human subjects for any purpose.
(5) The RECIPIENT shall not use the ORIGINAL CELL and CELL for any purpose other than the academic research
purpose of conducting the research set forth in the MATERIAL TRANSFER AGREEMENT (hereinafter referredas “RESEARCH PROJECT”).
(6) The RECIPIENT shall receive the prior written approval from KYOTO UNIVERSITY, if the RECIPIENT uses
the ORIGINAL CELL and CELL with anyone else outside of the RECIPIENT’S laboratory to carry out theRESEARCH PROJECT.
(7) The ORIGINAL CELL and CELL shall be used only by the RECIPIENT and others working under
RECIPIENT’S direct supervision at the RECIPIENT laboratory, and shall not be used by, as well as shall not be
distributed and assigned to anyone else either at the RECIPIENT organization or outside the organization.
(8) At the time of publication of the result from using the ORIGINAL CELL and/or CELL in the RESEARCH
PROJECT, whether in print or in electronic form, the RECIPIENT shall provide a copy of each publication toKYOTO UNIVERSITY.
iPS Cells Team
Center for iPS Cell Research and Application (CiRA),
Kyoto University
E-mail: cira-keiyaku@cira.kyoto-u.ac.jp
FAX: 81-75-366-7023
URL: http://www.cira.kyoto-u.ac.jp/e/index.html(9) The RECIPIENT acknowledges that this Agreement is not the agreement to license the intellectual property rights
relating the ORIGINAL CELL and CELL owned by KYOTO UNIVERSITY to the RECIPIENT. TheRECIPIENT also acknowledges that no express or implied licenses or other rights are provided to the RECIPIENT
from KYOTO UNIVERSITY to use the ORIGINAL CELL, CELL, or any related patents of KYOTO
UNIVERSITY for commercial purposes.
(10) The RECIPIENT agrees to grant to KYOTO UNIVERSITY a non-exclusive, royalty-free licenses, toRECIPIENT’s interest in any inventions or discoveries which are acquired by its use of the ORIGINALCELL and CELL, for teaching and academic research purposes, and will not exercise such intellectual
property rights against KYOTO UNIVERSITY for such purpose.
(11) The RECIPIENT agrees that KYOTO UNIVERSITY makes no representations and extends no warranties of anykind, either expressed or implied. There are no express or implied warranties of merchantability or fitness for aparticular purpose, or that the use of the ORIGINAL CELL, CELL and any cell derived from the ORIGINALCELL will not infringe any patent, copyright, trademark, or other proprietary rights. The RECIPIENT assumes all
liability for damages which may arise from its use, storage or disposal of the ORIGINAL CELL, CELL and any cell
derived from the ORIGINAL CELL. KYOTO UNIVERSITY will not be liable to the RECIPIENT for any loss,
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Cell TERMS and CONDITIONS
2013.12.02
claim or demand made by the RECIPIENT, or claim or demand by any other party made against the RECIPIENT,
due to or arising from the use of the ORIGINAL CELL, CELL and any cell derived from the ORIGINAL CELL by
the RECIPIENT.
(12) The RECIPIENT shall cite the paper specified below in any publication of the result from the RESEARCH
PROJECT.
Okita, K. et al., Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors. Science 322: 949(2008)(13) The RECIPIENT acknowledges that the ORIGINAL CELL was created through introduction of transgenes andthat any experiments with implantation or inoculation of the ORIGINAL CELL into living organisms will bedeemed recombinant DNA experiment. The RECIPIENT agree to comply with all laws, rules and regulations
applicable to perform recombinant DNA experiment and secure necessary approval before conducting suchexperiments.
(14) The RECIPIENT agrees that RIKEN informs to KYOTO UNIVERSITY of the RECIPIENT name, theRECIPIENT institution, the title of the RESEARCH PROJECT and the date of distribution.

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