The International Pancreas Research Forum 2017

Honor President
Tadashi Takeuchi
Pancreatic Research
Foundation of Japan

Council Member
Tatsuji Homma

Tooru Shimosegawa

Emeritus, Shinshu University
School of Medicine

President of Japan Pancreas Society,
Division of Gastroenterology, Tohoku
University Graduate school of Medicine

Organizing Commitee
Keiko Shiratori

Kazuichi Okazaki

Pancreatic Research Foundationof Japan

Department of Gastroenterology
and Hepatology, Kansai MedicalUniverisity

Kyoko Shimizu

Teruo Nakamura

Tokyo Women's Medical University
Department of Gastroenterolog

Health Care Center, Hirosaki
Medical Association

Terumi Kamisawa

Takao Itoi

Department of Internal Medicine,Tokyo Metropolitan Komagome
Hospital

Department of Gastroenterology
and Hepatology, Tokyo MedicalUniversity

Hirotaka Ohara

Atsushi Masamune

Department of Community-based MedicalEducation, Nagoya City University Graduate
School of Medical Sciences

Division of Gastroenterology,
Tohoku University Graduate
school of Medicine

Takeji Umemura

Hideaki Hamano

Department of Gastroenterology,
Shinshu University School ofMedicine

Medical Informatics Division,
Shinshu University Hospital－ 3－

Program of International Pancreas Research Forum(IPRF) 2017■ October 28th, 2017
■ Hotel Buena Vista in Matsumoto“The gateway from autoimmune pancreatitis to IgG4-related disease”
8:00-Registration

8:45-8:50

Opening Remarks
Shigeyuki Kawa (Department of Internal Medicine, Matsumoto Dental University)

8:50-9:00

Key Note Lecture
Establishment of Autoimmune Pancreatitis as a New Clinical Entity
Tadashi Takeuchi (Pancreatic Research Foundation of Japan)
Chaired by Shigeyuki Kawa (Department of Internal Medicine, Matsumoto Dental University)

9:00-9:20

Opening Lecture
Recollections of IgG4 Study at Shinshu University
Shigeyuki Kawa (Department of Internal Medicine, Matsumoto Dental University)
Chaired by Keiko Shiratori (Pancreatic Research Foundation of Japan)

9:25-11:10

Symposium 1“Epidemiology and pathogenesis of autoimmune pancreatitis”
Chaired by Kazuichi Okazaki (Kansai Medical University) and
Myung-Hwan Kim (Asan Medical Center)
Part 1
1) A nationwide epidemiological survey of autoimmune pancreatitis in Japan (15 min)Atsushi Kanno (Tohoku University)2) Immunological Aspects in Type 1 Autoimmune Pancreatitis (15 min)Kazushige Uchida (Kansai Medical University)3) Molecular pathology of autoimmune pancreatitis (15 min)Yoh Zen (Kobe University)4) A mouse model of flagellin-dependent pancreatitis under immune hypersensitivity (15 min)Naoko Yanagisawa (Tokyo Women's Medical University)－ 6－

The International Pancreas Research Forum 2017

Part 25) Pathogenesis of autoimmune pancreatitis (15min)
Masahiro Shiokawa (Kyoto University)6) Alteration of serum N-glycan profile in patients with autoimmune pancreatitis (15min)
Takeshi Tomoda(Departments of Gastroenterology & Hepatology, Okayama University
Graduate School of Medicine)
General discussion and comments: 10 min(1) Kyoko Shimizu (Tokyo Women's Medical University)(2) Akiyoshi Nishio (Kansai Medical University)
11:15-12:15

Poster Round
Presentation and Discussion
Poster award, Young investigator travel award (selected by abstract)12:20-13:25

Topic Seminar (with lunch)“Recent advances in type 2 autoimmune pancreatitis”
Chaired by Keiko Shiratori (Pancreatic Research Foundation of Japan)
1) Pathology; diagnostic accuracy of EUS-FNA biopsy (15min)
Kenji Notohara (Kurashiki Central Hospital)
2) Recent advances in type 2 autoimmune pancreatitis
Experience in Korea: Myung-Hwan Kim (15min) (Asan Medical Center)
Comparison of imaging findings between type 1 and type 2 autoimmune pancreatitis
by ICDC: Toshiharu Ueki (15min) (Fukuoka University Chikushi Hospital)
Experience in USA: Suresh T Chari (15min) (Mayo Clinic)

13:30-15:15

Symposium 2“long-term outcome of autoimmune pancreatitis”
Chaired by Atsushi Masamune (Tohoku University Graduate School ofMedicine) and Suresh Chari (Mayo Clinic)
1) Low-dose Maintenance Steroid Treatment Could Reduce the Relapse Rate in Patients with Type 1
Autoimmune Pancreatitis : A Long-term Japanese Multicenter Analysis of 510 patients (15min)
Kensuke Kubota (Yokohama City University Graduate School of Medicine)－ 7－2) Relation to chronic state and malignancy (30min)(1) Autoimmune pancreatitis can develop into chronic pancreatitis (15min)
Masahiro Maruyama (Shinshu University)(2) Malignancy and autoimmune pancreatitis (15min)
Masahiro Shiokawa (Kyoto University)3) Experience in USA (15min)
Suresh T Chari (Mayo Clinic)
4) Experience in Korea (15min)
Myung-Hwan Kim (Asan Medical Center)5) Experience in Taiwan (15min)
Wei-Chih Liao (National Taiwan University Hospital)
General discussion and comments: 10 min(1) Takao Itoi (Department of Gastroenterology and Hepatology, Tokyo
Medical University)(2) Miyuki Yanagimachi（Department of Endocrinology and Metabolism,
Hirosaki University Graduate School of Medicine）
15:15-15:30

Coffee Break

15:30-16:55

Symposium 3“Overview of IgG4-RD”
Chaired by Terumi Kamisawa (Tokyo Metropolitan Komagome Hospital)and Wei-Chih Liao (National Taiwan University Hospital)
1) History of IgG4-related disease (IgG4-RD) (15min)
Hideaki Hamano (Shinshu University)2) IgG4-related sclerosing cholangitis (15min)
Takahiro Nakazawa (Department of Gastroenterology Japanese Red
Cross Nagoya Daini Hospital)
3) Clinical practice in IgG4-related dacryoadenitis and sialadenitis: theresults from the SMART registry (15min)
Motohisa Yamamoto (Sapporo Medical University)4) IgG4-related kidney lesions (15min)
Mitsuhiro Kawano (Kanazawa University Graduate School of Medicine)5) IgG4-related hepatopathy (15min)
Takeji Umemura (Shinshu University)
General discussion and comments: 10 min(1) Hirotaka Ohara (Nagoya City University Graduate School of MedicalSciences)(2) Yusuke Tando (Hirosaki University School of Health Science)

16:55-17:00
17:05-18:45

Closing Remarks
Get-together Party－ 8－

The International Pancreas Research Forum 2017

Poster Presentation

11:15-12:15

Chair：Takayoshi Nishino Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical CenterKeisuke Tateishi Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
Naohiro Sata Department of Surgery, Jichi Medical University
Masanori Sugiyama Department of Surgery, Kyorin University School of Medicine

Group 1
■ P-1

Group 2
■ P-5

Relationship between serum interleukin-6
levels and clinical presentation in patientswith type 1 autoimmune pancreatitis

Yoko Matsuda, Makoto Nishimura, Yuko Fujii,
Miho Matsukawa, Tomio Arai

S. Tsukuda, T. Ikeura, K. Uchida, M. Takaoka,
M. Yanagawa, M. Ikemune, A. Nishio, K. Okazaki.

Department of Pathology and Endoscopy, Tokyo Metropolitan
Geriatric Hospital

The Third department of Internal Medicine, Kansai MedicalUniversity
■ P-2

■ P-3

■ P-6

Gender-specific differences ofextrapancreatic lesions in autoimmune
pancreatitis

Difference in insulin secretion improvement
after steroid therapy for autoimmune
pancreatitis according to the onset ofdiabetes mellitus

J. Tahara, K. Shimizu, T. Ito, F. Kinoshita,
N. Okuno, J. Akao, K. Nagao, Y. Takayama,
K. Tokushige

K Noguchi1, S Mizuno1, T Nakamura1, K Hirano1,R Uchino1, N Takahara1, H Kogure1, Y Nakai1,M Tada1, H Isayama2 and K Koike1.

Department of Medicine, Institute of Gastroenterology, Tokyo
Women’s Medical University, Tokyo Japan

1: Department of Gastroenterology, Graduate Schoolof Medicine, The University of Tokyo. 2: Department ofGastroenterology, Graduate School of Medicine, Juntendo
University

Pregnancy in autoimmune pancreatitis
N. Otsuka, K. Shimizu, T. Ito, F. Kinoshita,
J. Akao, K. Nagao, J. Tahara, Y. Takayama,
K. Tokushige.

■ P-7

Institute of Gastroenterology, Tokyo Women’s Medical University■ P-4

Pathological characteristics of EUS-FNA
sample from IgG4-related pancreatitis cases

Early pancreatic volume reduction on
CT predicts relapse in patients with type1 autoimmune pancreatitis treated withsteroids.
Yoshinori Ohno, Teru Kumagi, Tomoyuki Yokota,
Nobuaki Azemoto, Yoshinori Tanaka,
Kazuhiro Tange, Nobu Inada, Hideki Miyata,
Yoshiki Imamura, Mitsuhito Koizumi, Taira Kuroda,
Yoichi Hiasa. The EPOCH Study Group.

The long term prognosis of autoimmune
pancreatitis
M Yanagimachi1, E Sato1, Y Tando2,A Matsumoto1, M Daimon1, T Nakamura3.
1. Department of Endocrinology and Metabolism Hirosaki
University Graduate School of Medicine, 2. Division of Medical
Life Science Hirosaki University Graduate School of HealthScience, 3. Health Care Center, Hirosaki Medical Association

Department of Gastroenterology and Metabology, Ehime
University Graduate School of Medicine■ P-8

Clinical features of IgG4 negative
autoimmune pancreatitis.
Yoshinori Ohno1, Teru Kumagi1, Tomoyuki Yokota2,
Hideki Miyata3, Yoshinori Tanaka4,
Keitarou Kawasaki5, Fujimasa Tada6,
Nobuaki Azemoto7, Mitsuhito Koizumi1,
Taira Kuroda1, Yoshiki Imamura1 Yoichi Hiasa1,
on behalf of the EPOCH Study Group.
1Gastroenterology and Metabology, Ehime University Graduate
School of Medicine, 2Center for Liver-Biliary-Pancreatic Diseases,
Matsuyama Red Cross Hospital, 3Gastroenterology, Ehime
Prefectural Central Hospital 4Gastroenterology, Matsuyama
Municipal Hospital, 5Internal Medicine, Saiseikai Imabari Hospital,
6Internal Medicine, Saiseikai Matsuyama Hospital, 7National
Hospital Organization Shikoku Cancer Center.

－ 9－Group 3■ P-9

Incidence of Cancer and Risk Factors forComplication by Cancer in IgG4-Related
Sclerosing Cholangitis
T. Nishino, T. Hamano, M Kan, M.Tobari,K. Hashimoto, M. Shirato
Dept. of Gastgroenterology, Tokyo Women’s Medical University,
Yachiyo Medical Center, Chiba, JapanGroup 4■ P-13 Clinical features of IgG4-related periaortitis

Makiko Ozawa
Departments of Gastroenterology, Shinshu University School ofMedicine■ P-14 Performance characteristics of The Binding

Site antisera IgG4 immunoassay.
Markus Sköld, Stephen J. Harding, Antony Parker.

■ P-10 A case of pancreatic cancer associated withThe Binding Site Group Ltd, Birmingham, UK.

autoimmune pancreatitis.
Yoshiki Imamura, Teru Kumagi, Yoshinori Ohno,Taira Kuroda, Mitsuhito Koizumi, Hirofumi
Yamanishi, Nobuaki Azemoto, Masashi Hirooka,Yoichi Hiasa.

■ P-15 The activation of the estrogen receptor affectthe progression of pancreatic mucinous
cystic neoplasms
Yutaka Suzuki, Sangchul Kim, Hirokazu Momose,
Ryota Matsuki, Masaharu Kogure, Masaaki
Yokoyama, Nobutsugu Abe, Toshiyuki Mori,
Masanori Sugiyama

Gastroenterology and Metabology, Ehime University Graduate
School of Medicine.
■ P-11 Usefulness of laparoscopy and intraductal

ultrasonography in a patient with isolated
immunoglobulin G4-related sclerosing
cholangitis.

Department of Surgery, Kyorin University School of Medicine■ P-16 Two cases of drug-induced pancreatitis

associated with inflammatory bowel
disease requiring differentiation from type 2
autoimmune pancreatitis

Yoshiki Imamura, Teru Kumagi, Yoshinori Ohno,
Taira Kuroda, Mitsuhito Koizumi, Eiji Takeshita,
Masanori Abe, Yoichi Hiasa.

Toru Maruo1), Toshiharu Ueki1), Kenshi Yao2),
Fumihito Hirai3)

Gastroenterology and Metabology, Ehime University Graduate
School of Medicine.

1) Department of Gastroenterology, Fukuoka University Chikushi
Hospital2) Department of Endoscopy, Fukuoka University Chikushi
Hospital3) Inflammatory bowel disease center, Fukuoka University
Chikushi Hospital■ P-12 Endoscopic differences of proximal type

IgG4-related sclerosing cholangitis between
isolated type and type associated withautoimmune pancreatitis
Kensuke Kubota
Endoscopic Unit, Yokohama City University Hospital Yokohama,Japan－ 10 －