ICR ANNUAL REPORT 2023 (Volume 30) - ISSN 1342-0321 This Annual Report covers from 1 January to 31 December 2023

Editors:

Professor: OHKI, Yasuhiro
Professor: MIZUOCHI, Norikazu
Associate Professor: TOSAKA, Masatoshi
Assistant Professor: OKAZAKI, Daiki

Editorial Staff:

Public Relations Section: HATA, Eri
TAKEDA, Mayu
HIRAI, Naho
KATSURA, Seika
IWASHIRO, Kayana

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Request for Cooperation to the ICR’s 100th Anniversary Fund
ICR has established a fund called “The ICR’s
100th Anniversary Fund,” which is a part of the
Kyoto University Fund. Its aims are to hold the100th anniversary event in 2026, to enhance theeducational and research environments at ICR,
and to promote social contribution activities.
We ask for your kind understanding andcooperation.
■ https://www.kikin.kyoto-u.ac.jp/contribution/chemical/

ICR
ANNUALREPORT
2023

Institute for Chemical Research
Kyoto University

Volume 30

Preface
It is a great pleasure to publish the 30th volume of theInstitute for Chemical Research (ICR) Annual Report. ICR
was established as the first research institute of Kyoto
University in 1926, with the founding philosophy “To
Excel in the Investigation of Basic Principles of Chemistry
and Their Applications.” Since 1994, ICR Annual Reporthas been published annually to disseminate ICR’s current
activities worldwide. We currently have 120 faculty members, 200 graduate students, including 50 from abroad,and 60 researchers. These scientists are grouped into 30
laboratories divided into five research divisions—Synthetic
Chemistry, Materials Chemistry, Biochemistry, Environmental Chemistry, and Multidisciplinary Chemistry—and
three research centers—Advanced Research Center for
Beam Science, International Research Center for Elements
Science, and Bioinformatics Center. The laboratories arediversely affiliated with the graduate schools of science,engineering, agriculture, pharmaceutical sciences, medicine, and informatics.
The research of ICR encompasses a wide range of scientific disciplines, including physics, biology, and informatics as well as chemistry. ICR members conduct cuttingedge research not only in fields of their own specificdisciplines but also in interdisciplinary and innovative
fields. Some of outstanding research achievements in
2023 are as follows: 1) Unusual Nuclear Exchange within
a Germanium-Containing Aromatic Ring that Resultsin Germanium Atom Transfer; 2)Synthesis of Tertiary
Alkylphosphonate Oligonucleotides through Light-Driven
Radical-Polar Crossover Reactions; 3) Location-Selective
Immobilisation of Single-Atom Catalysts on the Surface
or within the Interior of Ionic Nanocrystals Using
Coordination Chemistry; 4) Magnetization Control of
Zero-Field Intrinsic Superconducting Diode Effect; 5)
Synergistic Surface Modification of Tin–Lead Perovskite
Solar Cells; 6) Generation of Third-Harmonic Spin

Oscillation from Strong Spin Precession Induced by
Terahertz Magnetic Near Fields; 7) Genomic Adaptationof Giant Viruses in Polar Oceans. Other distinctive
achievements were presented also in the 123rd ICR Annual
Symposium on December 1, 2023.
ICR collaborates with other research institutions on
projects including MEXT Inter-University Collaborative
Project “Integrated Consortium on Chemical Synthesis”,
MEXT Large-scale Scientific Research Project “Spintronics
Research Network of Japan”, and Research Unit for Realization of Sustainable Society in the Kyoto University
Research Coordination Alliance. We have also been engaged in over 60 international collaborations with overseas
universities and research institutions. In 2018, based on
our strong global activity in chemistry-oriented fields,
ICR was certified by MEXT as an International Joint
Usage/Research Center. To encourage young researchers
we have established several programs to support researchand postgraduate education, including an in-house annual
grant system, “ICR Grant for Promoting Integrated Research.” These collaborative achievements underline ourcommitment to promoting ICR as a global research hub inchemistry-related fields.
The world around us is undergoing a wave of changes.
The growing economy has exposed various global problems
including climate change and social inequity. For a just andsustainable society, science and technology must become acredible beacon of light. ICR contributes to this goal byproviding leadership and expertise in scientific research,fostering multidisciplinary, chemistry-related communities,
and developing new and technologically significant innovations. We hope this Annual Report will serve to update
you on the progress of our research activities and globalization. We appreciate your continued encouragement andsupport.
January 2024

AOYAMA, Takashi
Directoriii

ICR News 2023
Recently Published in Nature!
“Mirusviruses Link Herpesviruses to Giant Viruses”■ MENG, Lingjie and Prof OGATA, Hiroyuki
On April 19th, our work was published in Nature. In this work, we discovered a novel group of large DNA viruses
dubbed “Mirusviricota”. Most of double stranded DNA viruses are classified into one of two realms: Varidnaviria, which
includes giant viruses, and Duplodnaviria, which includes herpesviruses causing diseases in animals. These two realms
have been considered evolutionarily unrelated. However, the newly discovered mirusviruses possess features of both
realms. Genes of “informational module” for genome replication and gene expression were similar to those of Varidnaviria,
while genes of “virion module” that encode structural proteins were similar to those of Duplodnavira. This mosaic featureof mirusviruses suggests that herpesviruses evolved fromtailed bacterial viruses via ancestral protist-infecting
viruses, namely the ancestors of the modern day mirusviruses and herpesviruses. Furthermore, gene transfers of“informational genes” between the two realms probably
played crucial roles in their evolution. Mirusviruses appear to be prevalent and abundant in the sea and likely
infect a variety of protists. However, they were discovered by bioinformatics analyses of marine metagenomic
data, and there are currently no cultured viruses from thisgroup of viruses. This work was achieved by a collaboration with groups of scientists in France and Denmark.

10th Pacific Symposium on Radical Chemistry (PSRC-10)■ Prof YAMAGO, Shigeru
PSRC-10 was held at Obaku Plaza, Uji Campus. Since its
establishment in 2004, the PSRC has aimed to promote the development of organic radical chemistry in the world and mutual exchanges among researchers. A total of 186 researchers from 18
countries gathered for 55 oral research presentations (3 keynote
lectures, 28 special invited lectures, and 24 invited lectures) and
91 poster presentations. Recent research results in a wide range offields were presented, including reaction development using
photo-redox catalysts, precise polymer synthesis, and material
creation using radicals, and design, synthesis, and theory ofcomplex molecules in which multiple radicals interact with eachother. The participants were able to interact with each other in arelaxed atmosphere. Twelve students and post-doctoral fellows
were selected as poster award winners and presented with awards
at the closing ceremony.
Through these activities, we believe that we have successfully
achieved the original purpose of this conference, which was tofurther develop research in organic radical chemistry and to provide
a forum for international exchange among the research community.
We would like to express our deep appreciation for the cooperation and support not only of the conference participants, but alsoof all the people involved.

iv

New Collaboration Project Starts
Memorandum of Understanding Signed between Sungkyunkwan
University’s Institute for Energy Science and Technology and ICR■ Prof WAKAMIYA, Atsushi
On June 5, 2023, a delegation from Sungkyunkwan University (SKKU) led by Prof. Nam-Gyu Park, the director of
SKKU’s Institute of Energy Science and Technology, visited ICR. The purpose of the visit was to participate in the 1st
Kyoto-SKKU Workshop, which was held in cooperation with Prof. Wakamiya’s laboratory. During the workshop, a
Memorandum of Understanding (MOU) was signed between the Institute of Energy Science and Technology, SKKU, andICR, Kyoto University (Director, Prof. Takashi Aoyama) to encourage interdepartmental academic exchange. A collaborative project on perovskite solar cells was launched with the support of the International Collaborative Research Programof the Institute for Chemical Research (ICR), Kyoto University, and the Korean National Research Foundation (KNRF).
This initiative led to the establishment of the SKKU-Kyoto University Perovskite International Research Collaboration
Center (PIRCC) within the Institute of Energy Science and Technology at SKKU in Korea.

ICR Hosted Four Student Awardees from the Philippines
On the occasion of Talent-Spot 2023 Manila held in January 2023, ICR Travel Award was presented to 4 topperforming students out of 17 student candidates from the Philippines. In March 2023, the awardees, two of them werefrom University of the Philippines Diliman, and one each of the other two were from University of Santo Tomas and De
La Salle University.
They were invited to participate in a week-long research training at the laboratory of their utmost interest at ICR, Kyoto
University. At the conclusion of the training program, each of the awardees gave a short presentation of their researchexperience at ICR. Through the relaxed and open discussion, the students interacted with young researchers and faculty
members of ICR to promote networking. One of the students, Matthew Denwell Herrera, will join an ICR laboratory as a
MEXT scholar and pursue a Master’s degree from Kyoto University.

v

CONTENTS
Preface ...............................................................................................................................................................

iii

ICR News 2023 ................................................................................................................................................

iv

ORGANIZATION ..........................................................................................................................................

1

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIES ...........................................

3

Division of Synthetic Chemistry
Organoelement Chemistry .....................................................................................................................

4

Structural Organic Chemistry ................................................................................................................

6

Synthetic Organic Chemistry .................................................................................................................

8

Advanced Inorganic Synthesis ..............................................................................................................

10

Division of Materials Chemistry
Chemistry of Polymer Materials ...........................................................................................................

12

Polymer Controlled Synthesis ...............................................................................................................

14

Inorganic Photonics Materials ...............................................................................................................

16

Nanospintronics .....................................................................................................................................

18

Division of Biochemistry
Biofunctional Design-Chemistry ...........................................................................................................

20

Chemistry of Molecular Biocatalysts ....................................................................................................

22

Molecular Biology .................................................................................................................................

24

Chemical Biology ..................................................................................................................................

26

Division of Environmental Chemistry
Molecular Materials Chemistry .............................................................................................................

28

Hydrospheric Environment Analytical Chemistry ................................................................................

30

Chemistry for Functionalized Surfaces .................................................................................................

32

Molecular Microbial Science ................................................................................................................

34

Division of Multidisciplinary Chemistry
Polymer Materials Science ....................................................................................................................

36

Molecular Rheology ..............................................................................................................................

38

Molecular Aggregates ............................................................................................................................

40

Advanced Research Center for Beam Sciencevi

Particle Beam Science ...........................................................................................................................

42

Laser Matter Interaction Science ...........................................................................................................

44

Electron Microscopy and Crystal Chemistry ........................................................................................

46

Atomic and Molecular Structures ..........................................................................................................

48

International Research Center for Elements Science
Synthetic Organotransformation ............................................................................................................

50

Advanced Solid State Chemistry ...........................................................................................................

52

Organometallic Chemistry .....................................................................................................................

54

Nanophotonics .......................................................................................................................................

56

Bioinformatics Center
Chemical Life Science ...........................................................................................................................

58

Mathematical Bioinformatics ................................................................................................................

60

Bio-knowledge Engineering ..................................................................................................................

62

HAKUBI RESEARCHERS’ ACTIVITIES IN ICR ..............................................................................

65

ACTIVITIES OF INTERNATIONAL JOINT USAGE/RESEARCH CENTER ...........................

67

iJURC Cooperative Research Subjects 2023 ........................................................................................

68

iJURC Publications (Selected Examples) .............................................................................................

75

VISITING PROFESSORS’ ACTIVITIES IN ICR ................................................................................

77

PERSONAL ......................................................................................................................................................

79

Retirement .............................................................................................................................................

80

Awards ...................................................................................................................................................

82

Poster Awards ........................................................................................................................................

89

PUBLICATIONS ............................................................................................................................................

94

INTERNATIONAL RESEARCH COLLABORATIONS ....................................................................

106

SELECTED GRANTS ...................................................................................................................................

108

THESES ............................................................................................................................................................

118

THE 123RD ICR ANNUAL SYMPOSIUM .............................................................................................

120

SEMINARS ......................................................................................................................................................

123

MEETINGS AND SYMPOSIA ...................................................................................................................

126

INDEX ...............................................................................................................................................................

127

NAME INDEX ......................................................................................................................................

128

KEYWORD INDEX .............................................................................................................................

131

vii

Abbreviations used in the columns
Prof Em
Professor Emeritus
Prof
Professor
Vis Prof
Visiting Professor
Assoc Prof
Associate Professor
Vis Assoc Prof
Visiting Associate Professor
Senior Lect
Senior Lecturer
Assist Prof
Assistant Professor
Lect (pt)Lecturer (part-time)
Specially Appointed Prof
Specially Appointed Professor
Program-Specific Assoc Prof
Program-Specific Associate
Professor
Program-Specific Senior Lect
Program-Specific Senior Lecturer
Program-Specific Assist Prof
Program-Specific AssistantProfessor
Techn Staff
Technical Staff
Program-Specific Res
Program-Specific Researcher
Proj Res
Project Researcher
Support Staff
Support Staff
Assist Res Staff
Assistant Research Staff
Assist Techn Staff Assistant Technical Staff

viii

Guest Scholar
Guest Res Assoc
SPD (JSPS)

Guest Scholar
Guest Research Associate
Special Post-Doctoral
Research Fellow (JSPS)PD
Post-Doctoral Research Fellow
Res
Researcher
Res Support Staff Research Support Staff
RF
Research Fellow
D 1~3
Doctoral Course (Program) 1~3
M1~2
Master’s Course (Program) 1~2
RS
Research Student
UG
Undergraduate Student
D Sc
Doctor of Science
D Eng
Doctor of Engineering
D Agr
Doctor of Agricultural Science
D Pharm Sc
Doctor of Pharmaceutical Science
D Med Sc
Doctor of Medical Science
D Inf
Doctor of Informatics
D Human & Envirnmtl. Studies
Doctor of Human and­Environmental Studies
D Energy Sc
Doctor of Energy Science
Ph D
Doctor of Philosophy(pt)
part-timeORGANIZATION

Institute for Chemical Research
5 Divisions and 3 Centers

Laboratories

Research Divisions

Division of Synthetic Chemistry

Organoelement Chemistry
Structural Organic Chemistry
Synthetic Organic Chemistry
Advanced Inorganic Synthesis

Division of Materials Chemistry

Chemistry of Polymer Materials
Polymer Controlled Synthesis
Inorganic Photonics Materials
Nanospintronics

Division of Biochemistry

Biofunctional Design-Chemistry
Chemistry of Molecular Biocatalysts
Molecular Biology
Chemical Biology

Division of Environmental Chemistry

Molecular Materials Chemistry
Hydrospheric Environment Analytical Chemistry
Chemistry for Functionalized Surfaces
Molecular Microbial Science

Division of Multidisciplinary Chemistry

Polymer Materials Science
Molecular Rheology
Molecular Aggregates

Research Centers

Advanced Research Center for Beam Science

International Research Center for Elements Science

Particle Beam Science
Laser Matter Interaction Science
Electron Microscopy and Crystal Chemistry
Atomic and Molecular Structures
Synthetic Organotransformation
Advanced Solid State Chemistry
Organometallic Chemistry
Nanophotonics
Structural Organic Chemistry
Biofunctional Design-Chemistry

Bioinformatics Center

Chemical Life Science
Mathematical Bioinformatics
Bio-knowledge Engineering
GenomeNet Project Management Office

Visiting Divisions
International Joint Usage/Research Center
Supercomputer System
Low Temperature Laboratory

2

ORGANIZATIONTOPICS AND

INTRODUCTORY
COLUMNS OF
LABORATORIESDivision of Synthetic Chemistry– Organoelement Chemistry –https://www.scl.kyoto-u.ac.jp/~oec/en/index.html

Prof
Assoc Prof
YAMADA, Hiroko MIZUHATA, Yoshiyuki(D Sc)(D Sc)

Assist Prof *MATSUO, Kyohei(D Sc)

Assist ProfYAMAUCHI, Mitsuaki(D Eng)*New Research Field
Development ProjectTechn Staff *HIRANO, Toshiko*Re-employed Staff

Students
TSUJI, Shingo (D3)
YANG, Yi (D2)
UENO, So (D1)UCHIDA, Daichi (D1)KASAHARA, Shoma (D1)
AOKI, Takamasa (M2)PD
NISHINO, Ryohei(D Sc)

REN, Zhe (M2)SUZUKI, Shinjiro (M1)TERANISHI, Kento (M1)
WANG, Yutang (M1)
MIYAZAKI, Kazuya (RS)

Scope of Research
π-Extended aromatic compounds such as higher acenes and porphyrins are attractive as organic functional materials. In
particular, we focus on the control of thin-film structure by self-assembly of the materials to investigate the correlation
between packing structure and charge carrier mobility. We
are also interested in the compounds including heavy maingroup elements to elucidate the similarities and differencesin structures and reactivities between organic compounds
and the corresponding heavier congeners.

KEYWORDS
Organic Semiconductor
Self-Assembly
Reactive Intermediate

Aromatic Compound
Main Group Element

Recent Selected Publications
Miyazaki, K.; Matsuo, K.; Hayashi, H.; Yamauchi, M.; Aratani, N.; Yamada, H., An Unsymmetrical 5,15-Disubstituted Tetrabenzoporphyrin:
Effect of Molecular Symmetry on the Packing Structure and Charge Transporting Property, Org. Lett., 25, 7354-7358 (2023).
Nishino, R.; Tokitoh, N.; Sasayama, R.; Waterman, R.; Mizuhata, Y., Unusual Nuclear Exchange within a Germanium-Containing Aromatic
Ring That Results in Germanium Atom Transfer, Nature Commun., 14, 4519 (2023).
Iwai, K.; Mizuhata, Y.; Nakamura, T.; Goto, M.; Wakamiya, A.; Shimakawa, Y.; Tokitoh, N., Solid‐State Chromism of Zwitterionic Triarylmethylium
Salts, Eur. J. Inorg. Chem., 26, e202300337 (2023).
Jeong, E.; Ito, T.; Takahashi, K.; Koganezawa, T.; Hayashi, H.; Aratani, N.; Suzuki, M.; Yamada, H., Exploration of Alkyl-Group Effects on the
Molecular Packing of 5,15-Disubstituted Tetrabenzoporphyrins toward Efficient Charge-Carrier Transport, ACS Appl. Mater. Interfaces, 14,32319-32329 (2022).
Eimre, K.; Urgel, J. I.; Hayashi, H.; Giovannantonio, M. D.; Ruffieux, P.; Sato, S.; Otomo, S.; Chan, Y. S.; Aratani, N.; Passerone, D.; Gröning,O.; Yamada, H.; Fasel, R.; Pignedoli, C. A., On-Surface Synthesis and Characterization of Nitrogen-Substituted Undecacenes, Nat. Commun.,13, 511 (2022).

4

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Exploration of Alkyl Group Effects on the
Molecular Packing of 5,15- Disubstituted
Tetrabenzoporphyrins toward Efficient
Charge-Carrier Transport
The high design flexibility of organic semiconductors
should lead to diverse and complex electronic functions.
However, currently available high-performance organic semiconductors are limited in variety; most of p-type materials
are based on thienoacenes or related one-dimensionally(1D) extended π-conjugated systems. In an effort to expand
the diversity of organic semiconductors, we are working on
the development of tetrabenzoporphyrin (BP) derivatives
as active-layer components of organic electronic devices.
BP derivatives can afford field-effect hole mobilities of >4cm2 V−1 s−1 and the resulting thin films show high thermal
stability wherein the field-effect hole mobility stays above
1 cm2 V−1 s−1 even after heating at 160 °C in air, reflecting
the tight packing of large BP units. These findings willserve as a good basis for extracting the full potential of 2D
extended π-frameworks and thus for increasing the structural or functional diversities of high-performance organic
semiconductors.

Figure 1. Packing structure of 5,15-bis(n-octyldimethylsilylethynyl)
tetrabenzoporphyrin in the solution processed thin film.

surface formation of heptacene and nonacene via visiblelight-induced photo-dissociation of α-bisdiketone precursors
on an Au(111) substrate under ultra-high vacuum conditions. Through combined scanning tunneling microscopy/
spectroscopy and non-contact atomic force microscopy
investigations, we provide insight into the chemical andelectronic structure of these elusive compounds.

Figure 2. On-surface synthesis of nonacene from photoprecursor and its
STM, AFM, and STS images.

Development of Germanium Atom Transfer
Reaction
In organic synthesis, the synthetic strategy relies on thedivision of the target molecule into simpler substructures,the feasibility of which depends on the availability of thenecessary building blocks. A single atom is the simplest
and most ideal building block for all molecules, but formost elements, obtaining individual atoms for synthesis is
impractical. We have demonstrated that single atomic germanium can be introduced into various molecules by taking
advantage of the reactivity of the germabenzenyl anion, in
which the anionic carbon of the phenyl anion is replaced by
germanium. The method discovered in this research enables the controlled synthesis of molecules with “naked”
germanium and is expected to lead to the development ofvarious functional materials involving germanium.

On-Surface Light-Induced Generation ofHigher Acenes and Elucidation of Their
Open-Shell Character
Acenes are an important class of polycyclic aromatichydrocarbons which have recently gained exceptional attention due to their potential as functional organic semiconductors. Fundamentally, they are important systems tostudy the convergence of physico-chemical properties of
all-carbon sp2-frameworks in the one-dimensional limit;
and by virtue of having a zigzag edge topology they also
provide a fertile playground to explore magnetism ingraphenic nanostructures. We have demonstrated the on-

Figure 3. Germanium atom transfer reaction utilizing a germabenzenyl
anion.

ICR ANNUAL REPORT, 2023

5

Division of Synthetic Chemistry– Structural Organic Chemistry –https://www.scl.kyoto-u.ac.jp/~kouzou/en/index.html

Prof
MURATA, Yasujiro(D Eng)

Assoc Prof
Assist ProfHIROSE, Takashi HASHIKAWA, Yoshifumi(D Eng)(D Eng)Students
HUANG, Guanglin (D4)ZHANG, Zheng (D3)

HU, Weizhe (D3)GU, Jiajian (D2)

LIU, Zhibo (D1)SHIMURA, Reo (UG)

Guest Res Assoc
CHAOLUMEN (Ph D)

Inner Mongolia University, P. R. China, 1 August 2023–22 August 2023

Scope of Research
Fundamental studies are being conducted for the creation of new functional π-systems with novel structures andp­ roperties, and for evaluation of their application as organic semiconducting materials for photovoltaic and electroluminescent devices. The major subjects are: 1) organochemical transformation of fullerenes C60 and C70, specifically organic
synthesis of endohedral fullerenes by the technique of molecular surgery; 2) generation of ionic fullerene species and their application for
KEYWORDS
the synthesis of functional material; 3) synthesis of new carbon-rich
π-Conjugated Systems
Endohedral Fullerenesmaterials by the use of transition metal complex; and 4) creation of
Functional Materials
Helical Structures
new functional π-materials with unique photoelectric properties.
Radical Species

Recent Selected Publications
Zhang, Z.; Murata, Y.; Hirose, T., Circularly Polarized Luminescence of Hetero[n]helicenes with 2,1,3-Thiadiazole Rings at Both Ends: Designof Magnetically-Allowed Electronic Transitions via Heteroatom Embedding, Tetrahedron, 142, 133514 (2023).
Huang, G.; Ide, Y.; Hashikawa, Y.; Hirose, T.; Murata, Y., CH3CN@open-C60: An Effective Inner-Space Modification and Isotope Effect insidea Nano-Sized Flask, Chem.-Eur. J., 29, e202301161 (2023).
Hashikawa, Y.; Sadai, S.; Murata, Y., Bilateral π-Extension of an Open-[60]Fullerene in a Helical Manner, Chem. Commun., 59, 6560-6563(2023).
Sadai, S.; Hashikawa, Y.; Murata, Y., π-Extended Open-[70]Fullerenes with a Fused Azaacene, Org. Lett., 25, 2815-2819 (2023).
Hashikawa, Y.; Sadai, S.; Okamoto, S.; Murata Y., Near-Infrared-Absorbing Chiral Open [60]Fullerenes, Angew. Chem., Int. Ed., 62, e202215380(2023).

6

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Near-Infrared-Absorbing Chiral Open-[60]Fullerenes[60]Fullerene is an achiral molecular nanocarbon with Ihsymmetry while it could attain an inherent chirality depending upon a functionalization pattern. The conventional
chiral induction of C60 relies mainly upon a multiple addition, thus affording a mixture of achiral and chiral isomers.
In most cases, however, their chiral function would belargely offset by pseudo-mirror plane(s). These are major
obstacles to proceed further study on fullerene chirality
and yet leave its understanding elusive. In this study, wedeveloped a carbene-mediated synthesis of C1-symmetricchiral open-[60]fullerenes showing an intense far-red tonear-infrared absorption. The large dissymmetry factor
of |gabs| = 0.12 was confirmed at λ = 820 nm for circulardichroism in benzonitrile. This is, in general, unachievableby other small chiral organic molecules, demonstrating thepotential usage of open-[60]fullerenes as novel types ofchiral chromophores.

ative of a strengthened electron-accepting ability which ismainly attributed to a cage deformation as supported bycomputational studies. These results are demonstrative oftrapped species working as a modulator for external properties of [60]fullerenes from the interior.

Figure 2. Acetonitrile trapped within a [60]fullerene cage.

Design of Magnetically-Allowed Electronic
Transitions by Heteroatom Embedding for an
Efficient Circularly Polarized Luminescence(CPL)

Figure 1. An inherently chiral open-[60]fullerene.

CH3CN@open-C60: An Effective Inner-Space
Modification and Isotope Effect inside a
Nano-Sized Flask
The large orifice with a ring-atom count of 18 on a [60]fullerene cage was found to allow for a molecule of CH3CN
to be trapped inside the carbon nanocavity under highpressure conditions. The thus formed molecular complex
exhibited a higher polarity than the empty cage on silica
gel, reflecting an increased molecular dipole moment.
Furthermore, the encapsulation of CH3CN caused lessnegative reductions with respect to empty one, being indic-

Design of excellent circularly polarized luminescence(CPL) emitters requires chiral molecules with large transition magnetic dipole moments (TMDM, |m|). In thiswork [5]-, [7]-, and [9]helicene derivatives with 2,1,3thiadiazole rings at both ends were designed and synthesized. We revealed that the [9]helicene derivative (TD[9]H) showed an excellent CPL with a large glum of +0.04 at
520 nm in toluene, which was significantly larger than thatof unsubstituted carbo[7]helicene (glum = +0.008). Density
functional theory (DFT) calculations suggested that theremarkable glum of TD[9]H was attributed to the magnetically allowed transition with a large TMDM (|m| = 2.3 ×
10−20 erg G−1) for the S1→S0 transition.

Figure 3. Enhancement of the dissymmetry factor of CPL (glum) by heteroatom embedding.

ICR ANNUAL REPORT, 2023

7

Division of Synthetic Chemistry– Synthetic Organic Chemistry –https://www.fos.kuicr.kyoto-u.ac.jp/eng/

Prof
OHMIYA, Hirohisa(D Eng)Assist ProfNAGAO, Kazunori(D Sc)

Assist ProfMURAKAMI, Sho(D Pharm Sc)

Students
SATO, Yukiya (D3)SHIBUTANI, Shotaro (D3)
OTA, Kenji (D2)
ABE, Reiji (D1)
NAKAGAWA, Masanari (D1)
NAKAMURA, Rikako (D1)

MATSUO, Tomotoki (D1)MITSUI, Atsuhisa (D1)MIYAMOTO, Yusuke (D1)
OYA, Ryoto (M2)
GOTO, Yamato (M2)
TAKEKAWA, Yunosuke (M2)

WATANABE, Koh (M2)
SATO, Hinata (iD1)
TONOMURA, Asuka (M1)KISHIDA, Naoto (UG)
SHIMONO, Hiroki (UG)
TOGISHI, Kanata (UG)

Scope of Research
Our group has been carrying out innovative research on the radical-based organic synthesis bydesigning catalysts and chemical reactions as well as molecules. Our current research projects
include (1) radical-mediated organocatalysis such as N-heterocyclic carbene catalysis or organophotoredox catalysis; (2) radical modification of nucleic acids; and (3) molecular imaging
based on boron chemistry.

KEYWORDS
Synthetic Reactions
Photoredox Catalysis
Organocatalysis
Radical Reaction
Boron Molecule

Recent Selected Publications
Ota, K.; Nagao, K.; Hata, D.; Sugiyama, H.; Segawa, Y.; Tokunoh, R.; Seki, T.; Miyamoto, N.; Sasaki, Y.; Ohmiya, H., Synthesis of Tertiary
Alkylphosphonate Oligonucleotides through Light-Driven Radical-Polar Crossover Reactions, Nat. Commun., 14, 6856 (2023).
Goto, Y.; Sano, M.; Sumida, Y.; Ohmiya, H., N-Heterocyclic Carbene- and Organic Photoredox-Catalysed meta-Selective Acylation ofElectron-Rich Arenes, Nat. Synth., 2, 1037-1045 (2023).
Nakamura, R.; Yamazaki, T.; Kondo, Y.; Tsukada, M.; Miyamoto, Y.; Arakawa, N.; Sumida, Y.; Kiya, T.; Arai, S.; Ohmiya, H., Radical Caging
Strategy for Cholinergic Optopharmacology, J. Am. Chem. Soc., 145, 10651-10658 (2023).
Kodo T.; Nagao K.; Ohmiya H., Organophotoredox-Catalyzed Semipinacol Rearrangement via Radical-Polar Crossover, Nat. Commun., 13,2684 (2022).
Nakagawa M.; Matsuki Y.; Nagao K.; Ohmiya H., A Triple Photoredox/Cobalt/Brønsted Acid Catalysis Enabling Markovnikov Hydroalkoxylationof Unactivated Alkenes, J. Am. Chem. Soc., 144, 7953-7959 (2022).

8

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Synthesis of Tertiary Alkylphosphonate
Oligonucleotides through Light-Driven
Radical-Polar Crossover Reactions
Chemical modification of nucleotides can improve the metabolic stability and target specificity of oligonucleotide therapeutics,
and alkylphosphonates have been employed as charge-neutral
replacements for naturally-occurring phosphodiester backbones
in these compounds. However, at present, the alkyl moieties thatcan be attached to phosphorus atoms in these compounds arelimited to methyl groups or primary/secondary alkyls, and suchalkylphosphonate moieties can degrade during oligonucleotide
synthesis. The present work demonstrates the tertiary alkylationof the phosphorus atoms of phosphites bearing two 2’deoxynuclosides. This process utilizes a carbocation generated
via a light-driven radical-polar crossover mechanism. This protocol
provides tertiary alkylphosphonate structures that are difficult
to synthesize using existing methods. The conversion of these
species to oligonucleotides having charge-neutral alkylphosphonate linkages through a phosphoramidite-based approach was
also confirmed in this study.

N-Heterocyclic Carbene- and Organic
Photoredox-Catalysed meta-Selective Acylationof Electron-Rich Arenes
meta-Selective functionalization of electron-rich arenes provides
a complementary route to that of traditional organic synthesis. Inclassical electrophilic aromatic substitution reactions of electrondonating group-pendant arenes, C–H functionalization occurs at
the ortho- or para-positions. There have been numerous efforts toovercome this selectivity, and various synthetic methods havebeen developed, typically using transition metal catalysis.
Here we report a combined N-heterocyclic carbene- and organic
photoredox-catalysed method for meta-selective acylation ofelectron-rich arenes, using acyl imidazoles as acylating reagents.
This approach proceeds without directing groups or steric factors
required in transition metal-catalysed processes, resulting in the
opposite regioselectivity to conventional approaches such asFriedel–Crafts acylation. Mechanistic studies reveal the process
involves a sequence of single-electron oxidation of an electronrich arene followed by the radical–radical coupling between aketyl radical and an arene radical cation.

Radical Caging Strategy for Cholinergic
Optopharmacology
Photo-caged methodologies have been indispensable for elucidating the functional mechanisms of pharmacologically active
molecules at the cellular level. A photo-triggered removable unit
enables control of the photo-induced expression of pharmacologically active molecular function, resulting in a rapid increase in
the concentration of the bioactive compound near the target cell.
However, caging the target bioactive compound generally requires
specific heteroatom-based functional groups, limiting the types ofmolecular structures that can be caged. We have developed an
unprecedented methodology for caging/uncaging on carbon atoms
using a unit with a photo-cleavable carbon–boron bond. The
caging/uncaging process requires installation of the CH2–B groupon the nitrogen atom that formally assembles an N-methyl groupprotected with a photoremovable unit. N-Methylation proceedsby photoirradiation via carbon-centered radical generation. Using
this radical caging strategy to cage previously uncageable bioactive molecules, we have photocaged molecules with no generallabeling sites, including acetylcholine, an endogenous neuro­transmitter. Caged acetylcholine provides an unconventional
tool for optopharmacology to clarify neuronal mechanisms on thebasis of photo-regulating acetylcholine localization. We demonstrated the utility of this probe by monitoring uncaging in HEK
cells expressing a biosensor to detect ACh on the cell surface, as
well as Ca2+ imaging in Drosophila brain cells (ex vivo).

Figure 1. Synthesis of Tertiary Alkylphosphonate Oligonucleotides through Light-Driven Radical-Polar Crossover Reactions.

Figure 2. N-Heterocyclic Carbene- and Organic Photoredox-Catalysedmeta-Selective Acylation of Electron-Rich Arenes.

Figure 3. Radical Caging Strategy for Cholinergic Optopharmacology.

ICR ANNUAL REPORT, 2023

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Division of Synthetic Chemistry– Advanced Inorganic Synthesis –https://www.scl.kyoto-u.ac.jp/~teranisi/index_E.html

Prof
Assoc ProfTERANISHI, Toshiharu SAKAMOTO, Masanori(D Eng)(D Eng)Assist Prof
TAKAHATA, Ryo *(Ph D)

Assist Prof
Program-Specific Assoc ProfTAKEKUMA, Haruka SARUYAMA, Masaki(D Sc)(D Sc)*New Research Field
Development Project

Program-Specific Assist Prof Program-Specific Assist Prof
SATO, Ryota
MATSUMOTO, Kenshi(D Sc)(D Sc)

Students
CHIGA, Yuki (D3)
TIAN, Wu (D3)
XIA, Yan (D2)ZHU, Lingkai (D1)
JIN, Yirou (D1)
SAKAGUCHI, Himari (M2)

LEE, Hyunji (M2)
KUGE, Kyota (M1)
MUTO, Mitsuki (M1)

Scope of Research
We are focusing on the precise synthesis of inorganic
nanoparticles by ­controlling the primary (size, shape, composition, etc.) and secondary (spatial arrangement) structures totune properties such as electron confinement, carrier oscillation,
spin, and catalysis. These high-quality inorganic nanoparticles
are applied to both high-performance nanodevices (e.g., single
electron transistor, plasmon waveguide, and nanocomposite
magnet) and photo-energy conversion materials (e.g., overallwater splitting and solar cell).

KEYWORDS
Inorganic Nanomaterials
Oxidation Reduction Reactions

Quantum Dots
Photocatalysts

Plasmonics

Recent Selected Publications
Endo E.; Saruyama M.; Teranishi T., Location-Selective Immobilisation of Single-Atom Catalysts on the Surface or within the Interior ofIonic Nanocrystals Using Coordination Chemistry, Nat. Commun., 14, 4241 (2023).
Chiga Y.; Takahata R.; Suzuki W.; Mizuhata Y.; Tokitoh N.; Teranishi T, Isomer-Selective Conversion of Au Clusters by Au(I)-Thiolate Insertion.
Inorg. Chem., 62, 10049-10053 (2023).
Suzuki W.; Takahata R.; Chiga Y.; Kikkawa S.; Yamazoe S.; Mizuhata Y.; Tokitoh N.; Teranishi T., Control over Ligand-Exchange Positions ofThiolate-Protected Gold Nanoclusters Using Steric Repulsion of Protecting Ligands, J. Am. Chem. Soc., 144, 12310-12320 (2022).

10

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Location-Selective Immobilization ofSingle-Atom Catalysts on the Surface orWithin the Interior of Ionic Nanocrystals
Using Coordination Chemistry
Single-atom catalysts dispersed on support materials
show excellent heterogeneous catalytic properties that canbe tuned using the interactions between the single atoms
and the support. Such interactions depend on whether the
single atoms are located on the surface or within the interiorof the support. However, little is known about immobilising single atoms on the surface or within the interior of
supports deliberately and selectively. Herein, such locationselective placement of single atoms is achieved throughthe choice of metal complex precursor, solvent, and workup procedure. (Figure 1) Using CdSe nanoplatelets as asupport, a cis-[PtCl2(SO(CH3)2)2] precursor in an aprotic
solvent exclusively attaches single Pt atoms on the surfaceof the support. In contrast, a [PtCl4]2− precursor in a protic
solvent followed by amine treatment places 60% of thesingle Pt atoms inside the support by cation substitution.
The surface-adsorbed single Pt atoms show higher stability
in photocatalytic hydrogen evolution than the substitutedones, and the preclusion of substitution as internal Pt
maximises the activity. Thus, this study provides a viablestrategy for the structurally precise synthesis and design ofsingle-atom catalysts.

Figure 1. Location-selective immobilization of Pt single atoms on thesurface or within the interior of CdSe nanocrystals and its effects on photocatalytic hydrogen evolution.

Control over Ligand-Exchange Positions ofThiolate-Protected Gold Nanoclusters Using
Steric Repulsion of Protecting Ligands
Organic ligands on gold nanoclusters play importantroles in regulating the structures of gold cores. However,
the impact of the number and positions of the protecting
ligands on gold-core structures remains unclear. We isolated
thiolate-protected Au25 cluster anions, [Au25(SC2Ph)17(Por)1]−
and [Au25(SC2Ph)16(Por)2]− (SC2Ph = 2-phenylethanethiolate),
obtained by ligand exchange of [Au25(SC2Ph)18]− with one
or two porphyrinthiolate (Por) ligands as mixtures ofregioisomers. (Figure 2) The ratio of two regioisomers in[Au25(SC2Ph)17(Por)1]− as measured by 1H NMR spectroscopy revealed that the selectivity could be controlled by
the steric hindrance of the incoming thiols. Extended X-ray
absorption fine structure studies of a series of porphyrincoordinated gold nanoclusters clarified that the Au13 icosahedral core in the Au25 cluster was distorted through steric
repulsion between porphyrin thiolates and phenylethanethiolates. This study reveals interesting insights into theimportance of the steric structures of protecting ligands forcontrol over core structures in gold nanoclusters.

Figure 2. Strategy for control over regioselectivity of [Au25SR18]– by steric effect.

ICR ANNUAL REPORT, 2023

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Division of Materials Chemistry– Chemistry of Polymer Materials –http://www.cpm.kuicr.kyoto-u.ac.jp/index_en.html

Prof
TSUJII, Yoshinobu(D Eng)Assist ProfKINOSE, Yuji
(D Eng)Assist ProfISHIDA, Koichiro(Dr Agr)

Researchers (pt)
MATSUKAWA, Kimihiro (D Eng)*
SEO, Haruna

MORIKI, Yoshihito
YANADA, Mizuho*Res of Kyoto Inst Technol

Students
TAMAMOTO, Ken (D3)KAMEDA, Monami (M2)
FUJIMOTO, Seitarou (M2)HOSOYA, Tomoki (M2)
AKAGI, Shikoh (M1)
SEIKE, Yuki (M1)KISHIDA, Takaki (UG)
YOSHIGAI, Toshiya (UG)
GOTO, Haruki (UG)

Scope of Research
We perform kinetic and mechanistic analyses toward understanding chemical and physicochemical reactions occurringin polymerization ­systems and better routes for synthesis of well-defined polymers. In p­ articular, new well-defined polymers or polymer assemblies are prepared by living polymerization techniques, and their structure–properties relationships
are precisely analyzed. Projects in progress include: 1)
kinetics and mechanisms of living radical polymerization(LRP); 2) synthesis of new polymeric materials by living­polymerizations and their structure/properties studies; and3) synthesis, properties, and applications of concentrated
polymer brushes (CPB).

KEYWORDS
Precision Polymerization
Polymer BrushHybrid Materials

Living Radical Polymerization
Tribology

Recent Selected Publications
Nakanishi, Y.; Ishige, R.; Ogawa, H.; Huang, Y.; Sakakibara, K.; Ohno, K.; Kanaya, T.; Takenaka, M.; Tsujii, Y., Unified Explanation for
Self-Assembly of Polymer-Brush-Modified Nanoparticles in Ionic Liquids, Polymer Journal, 55, 1199-1209 (2023).
Okubo, H.; Kagiwata, D.; Sasaki, S.; Tsujii, Y.; Nakano, K., Operando Tribo-Raman Spectroscopic Observation for Wear Processes of Superlow
Frictional Concentrated Polymer Brushes at Frictional Interface, Polymer Testing, 127, 108170 (2023).
Ishida, K.; Kondo, T., Evaluation of Surface Free Energy Inducing Interfacial Adhesion of Amphiphilic Cellulose Nanofibrils, Biomacromolecules,
24, 3786-3793 (2023).
Sakakibara, K.; Tsujii, Y., Visualization of Fibrillated Cellulose in Polymer Composites Using a Fluorescent-Labeled Polymer Dispersant, ACS
Sustainable Chemistry and Engineering, 11, 9332-6342 (2023).
Ishida, K.; Kondo, T., Anisotropic Frictional Properties Induced by Cellulose Nanofibril Assembly, Biomacromolecules, 24, 3009-3015 (2023).

12

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Precision Synthesis of Asymmetric Cellulose
Nanocrystals with Regioselectively
End-Grafted Polymer Brushes
The cellulose nanocrystal (CNC), which is a nanoparticle
obtained by hydrolysis of cellulose, has many intriguing properties,
including strength, stiffness, biocompatibility, biodegradability,and high aspect ratio. Notably, recent advancements have been
made in selectively modifying aldehyde groups located at the reducing edge of CNC with end-grafted polymer chains. Nanoparticles
with high-density, concentrated polymer brush (CPB) can form
colloidal crystals because of the high resistance against compression and the extremely low friction of the CPB layer. Therefore,
we hypothesized that the CNC, with two types of polymers (ofdifferent molecular weights) regioselectivity grafted on its reducing edge and other sides (referred to as an asymmetric polymerbrush-modified nanorod: asym-PB nanorod, Fig. 1), could form
novel higher-order structures because of its asymmetric shapeand interparticle repulsive potential.
In this study, we have developed a novel synthetic route forasym-PB nanorods. This involves the introduction of azido groups
to the reducing edge of CNC followed by the click reaction tocouple reversible addition-fragmentation chain transfer (RAFT)
polymerization initiators. Subsequently, atom transfer radical
polymerization (ATRP) initiators were introduced to hydroxyl
groups on the CNC-side surface to yield a CNC macroinitiator(Fig. 1). Finally, successive RAFT polymerization and ATRP
were conducted to obtain the desired asym-PB nanorod. We haveconfirmed that thus obtained asym-PB nanorod had densely graftedpolymer chains at the reducing edge and other CNC-side surface
through various evaluations. The surface pressure−area per molecule (π−A) isotherms of the asym-PB nanorod showed a distinctive
plateau (Fig. 2), suggesting a phase transition occurring possibly
thanks to the polymer brush of high molecular weight at the reducing edge. The details studies are now in progress, and ourultimate objective is to create a novel higher-order structure ofasym-PB nanorods.

Figure 1. Synthetic scheme for asym-PB nanorod.

Figure 2. π−A curves for asym-PB nanorod and its analogue.

Hydration Water and Anti-Icing Functions ofHydrophilic Concentrated Polymer Brushes
Hydrophilic concentrated polymer brushes (CPBs) are expected
to exhibit antifouling, antifogging, and anti-icing functions,which have been actively studied. To comprehensively understand the mechanism of these functions, it is essential to understand the interaction between CPB and water. However, there are
only a few studies on direct measurement of such interactions,and in particular, its analysis and observation at low temperatures,
which are important for elucidating the mechanism of the antiicing property, have not yet been accomplished. One of the reasonsfor this is that CPB is usually an ultra-thin film, making it difficult
to apply general-purpose analytical methods. Recently, we succeeded in synthesizing hydrophilic CPBs that are an order ofmagnitude thicker than previously possible. In this study, we havechallenged to directly observe the hydration state of water inside
CPB, which had never been achieved before, using CPBs with anultra-large thickness as the key materials. The results are discussed in relation to the anti-icing property at the CPB interface.
Through the atom transfer radical polymerization of poly (ethylene glycol) methyl ether methacrylate (PEGMA) as a monomer,a hydrophilic CPB with a thickness of about 1 µm was synthesized on a Si wafer. The ice adhesion strength was measured byhorizontally peeling off a cylndrical ice pillar prepared on a surfacemodified Si wafer in a temperature-controlled microscopic stage.
The results are shown in Fig. 3, suggesting that the effect wasabove the icephobic level, which is based on 100 kPa or lower. In
addition, the hydration state of water-swollen CPB was analyzed
by infrared microspectrometry (Fig. 4). It was observed thatwater inside the brush does not freeze even at low temperatures,and this is considered to be responsible for the excellent anti-icing
function. Further investigation is currently on-going.

Figure 3. Temperature dependency of ice adhesion strength tice for CPB.

Figure 4. IR spectra of the water-containing PPEGMA-CPB at positions
near a water droplet as a function of temperature.

ICR ANNUAL REPORT, 2023

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Division of Materials Chemistry– Polymer Controlled Synthesis –http://os.kuicr.kyoto-u.ac.jp/index.html

Prof
YAMAGO, Shigeru(D Sc)PDSHARKER, Komol Kanta(Ph D)

Assoc Prof
Assist ProfTOSAKA, Masatoshi KAYAHARA, Eiichi(D Eng)(D Eng)PD
JIANG, Yuhan(D Eng)PD
LI, Yanbang(Ph D)PD
TOUSSAINT, François(Ph D)

Students
WU, Jia-De (D3)YAMIN, Naila (D2)MARU, Kousuke (M2)

Techn Staff
FUJIHASHI, Akiko

OKAHARA, Ryota (M2)
TONG, Tianxiang (M2)
FU, Jincheng (M2)

HAMADA, Kouki (M1)
MIYOSHI, Nanami (M1)
XIE, Xuanhao (M1)

IMAI, Hiroki (UG)
TORIGOE, Yuga (UG)
NAGASHIMA, Chihiro (UG)

Scope of Research
Our research focuses on creation of new organic molecules withpotential as key reagents and materials for ­future science and technologies. Furthermore, we have been developing new organic and polymeric materials based on our tailor-made molecules. For example, weare developing a new living radical polymerization method usingheavier heteroatom compounds as controlling agents. Another topic is
the synthesis of cycloparaphenylenes, hoop-shaped π-conjugated­molecules, based on new synthetic strategies. We also study various
condensed states of polymers by both static and dynamic methods tounderstand the relationship between structure and physical properties.

KEYWORDS
Organic Synthesis

Polymer Synthesis

Living Radical Polymerization

Polymer Properties

Curved π-Conjugated Molecules

Recent Selected Publications
Jiang, Y.; Kibune, M.; Tosaka, M.; Yamago, S., Practical Synthesis of Dendritic Hyperbranched Polyacrylates and Their Topological Block
Polymers by Organotellurium-Mediated Emulsion Polymerization in Water, Angew. Chem. Int. Ed., 62, e202306916 (2023).
Tosaka, M.; Takeuchi, H.; Kibune, M.; Tong, T.; Zhu, N.; Yamago, S., Stochastic Simulation of Controlled Radical Polymerization of Dendritic
Hyperbranched Polymers, Angew. Chem. Int. Ed., 62, e202305127 (2023).
Terabayashi, T.; Kayahara, E.; Mizuhata, Y.; Tokitoh, N.; Nishinaga, T.; Kato, T.; Yamago, S., Synthesis of Twisted [n]Cycloparaphenylenes
by Alkene Insertion, Angew. Chem. Int. Ed., 62, e202214960 (2023).
Jiang, Y.; Fan, W.; Tosaka, M.; Yamago, S., Controlled Synthesis of High-Molecular-Weight Polystyrene and Its Block Copolymers by Emulsion
Organotellurium-Mediated Radical Polymerization, ACS Macro Lett., 11, 1331-1335 (2022).
Imamura, Y.; Yamago, S., Role of Lewis Acids in Preventing the Degradation of Dithioester-Dormant Species in the RAFT Polymerization of
Acrylamides in Methanol to Enable the Successful Dual Control of Molecular Weight and Tacticity, Polym. Chem., 12, 5336-5341 (2021).

14

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Stochastic Simulation of Controlled Radical
Polymerization Forming Dendritic
Hyperbranched Polymers
The formation process of hyperbranched polymers(HBPs) based on the reversible deactivation radical
polymerization (RDRP) using a branch-inducing monomer,
evolmer, was investigated by stochastic simulation. Ouroriginal simulation program successfully reproduced thechange of dispersities (Đs) during the polymerization process. Based on the simulation, we found that the observedĐs (=1.5–2) are due to the distribution of the number ofbranches instead of undesired side reactions. We Further
found that the branch structures are well controlled. so themajority of HBPs have structures close to the ideal one(Fig. 1). The simulation also suggested that, if we pay attention to individual molecules, the branch density slightly
changes depending on molecular weight. This trend wasexperimentally confirmed by synthesizing HBPs with anevolmer having a phenyl group and analyzing the signal
intensity from multiple detectors in size exclusion chromatography.

Synthesis of Twisted [n]Cycloparaphenylene
by Alkene Insertion
By fusing CPP precursors and alkene or ortho-phenylenegroups via coupling reactions, mono-alkene-inserted [n]cycloparaphenylenes 1 [(ene)-[n]CPP] with n = 6, 8, and10, mono-ortho-phenylene-inserted [6]CPP 2, and dialkene-inserted [n]CPP 3 [(ene)2-[n]CPP] with n = 4, 6,
and 8 were synthesized. Single-crystal X-ray diffraction
analyses revealed that the strips formed by the π-surfacesof 1 and 2 exhibited a Möbius topology in the solid state.
The Möbius topology in the parent 1 and 2 in a solution
was lost due to the free rotation of the paraphenylene unit
even at low temperatures. On the other hand, ene- [6]CPP
4 with eight 1-pyrrolyl groups preserved the Möbius topology even in a solution. Despite a twist, 1 has in-plane conjugation and possesses a unique size dependence of theelectronic properties; i.e., the opposite size dependencyof the HOMO-LUMO energy relative to conventional
π-conjugated molecules.

Figure 2. Insertion of alkene or ortho-phenylene units into a CPP skeleton.

Figure 1. Weight distribution of simulated structure of HBP.

ICR ANNUAL REPORT, 2023

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Division of Materials Chemistry– Inorganic Photonics Materials –http://mizuochilab.kuicr.kyoto-u.ac.jp/indexE.html

Prof
MIZUOCHI, Norikazu(D Sc)

Assist ProfMORIOKA, Naoya(Ph D)

Program-Specific Assist Prof Program-Specific Res
Assist ProfSHIGEMATSU, Ei HERBSCHLEB, Ernst David FUJIWARA, Masanori(Ph D)(D Sc)(D Eng)

Program-Specific Res

Researchers (pt)

NISHIKAWA, Tetsuri (D Eng)

OHKI, Izuru (D Bioscience)
KAWASHIMA, Hiroyuki (Ph D)

Students
Program-Specific Res
NAKAMURA, Masaya

MORITA, Kouki (D3)SO, Frederick Tzekit (D3)KAWASE, Riku (D1)HARIKI, Nene (M2)
NEMOTO, Masaya (M2)
OKAJIMA, Kazuki (M1)

KAMIYAMA, Naoya (M1)
OHORI, Masanao (UG)
KONDO, Kazuo (UG)

Scope of Research
NV centers in diamond have been extensively interested
because a single spin of the NV center can be manipulated
and detected at room temperature. Furthermore, a spin-­coherence time of the NV center is very long. The spin-­coherence time is the time to retain coherence (superposition state) and directly relates to the sensitivity of sensors
of magnetic field, electric field and temperature. Therefore, the unique and excellent properties of the NV centerare expected to be applied for quantum computing, quantum communication, bio-imaging, and high-sensitive sensor with nano-scale resolution.

KEYWORDS
Diamond
Quantum Materials
NV Center
Quantum Sensing
Quantum Information Science

Recent Selected Publications
Fujiwara, M.; Fu, H.; Hariki, N.; Ohki, I.; Makino, Y.; Liu, M.; Tsurui, A.; Yoshikawa, T.; Nishikawa, M.; Mizuochi, N., Germanium-Vacancy
Centers in Detonation Nanodiamond for All-Optical Nanoscale Thermometry, Appl. Phys. Lett., 123, 181903 (2023).
Morishita, H.; Morioka, N.; Nishikawa, T.; Yao, H.; Onoda, S.; Abe, H.; Ohshima, T.; Mizuochi, N., Spin-Dependent Dynamics of Photocarrier
Generation in Electrically Detected Nitrogen-Vacancy-Based Quantum Sensing, Phys. Rev. Appl., 19, 034061 (2023).
Fujiwara, M.; Inoue, S.; Masuno, S.; Fu, H.; Tokita, S.; Hashida, M.; Mizuochi, N., Creation of NV Centers over a Millimeter-Sized Region by
Intense Single-Shot Ultrashort Laser Irradiation, APL Photonics, 8, 036108 (2023).

16

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Ultra-Long Coherence Times Amongst RoomTemperature Solid-State Spins
Solid-state single spins are promising resources forquantum sensing, quantum-information processing andquantum networks, because they are compatible with scalable quantum-device engineering. However, the extensionof their coherence times proves challenging. Although enrichment of the spin-zero 12C and 28Si isotopes drasticallyreduces spin-bath decoherence in diamond and silicon, thesolid-state environment provides deleterious interactions
between the electron spin and the remaining spins of its
surrounding. Here we demonstrate, contrary to widespread
belief, that an impurity-doped (phosphorus) n-type single-­
crystal diamond realises remarkably long spin- coherence
times. Single electron spins show the longest inhomogeneous spin-dephasing time (T2* ≈ 1.5 ms) and Hahn-echo
spin-coherence time (T2 ≈ 2.4 ms) ever observed inroom-temperature solid-state systems, leading to the best
sensitivities (amongst others such as temperature), which
we confirmed for AC magnetic fields. From the analysis of
the noise spectrum, the elongation of T2 could be realisedby optimising the phosphorus concentration and by continuing to decrease the paramagnetic impurities and defects.
The extension of coherence times in diamond semi­
conductor may allow for new applications in quantum
technology.

Figure 1. Echo signal of the single NV centre at room temperature. (Insert) Bloch sphere to show the coherence (superposition state).

Extension of the Coherence Time by Generating MW Dressed States in a Single NV Centre
in Diamond
Nitrogen-vacancy (NV) centres in diamond hold promise in quantum sensing applications. A major interest inthem is an enhancement of their sensitivity by the extension of the coherence time (T2). In this report, we experimentally generated more than four dressed states in a single NV centre in diamond based on Autler-Townes splitting(ATS). We also observed the extension of the coherencetime to T2 ~ 1.5 ms which is more than two orders of magnitude longer than that of the undressed states. Numericalestimations show the sensitivity of the quantum sensing
with the dressed states can be enhanced at least one-orderof magnitude with experimentally observed T2ρ and T2.
Thus, we believe that the quantum sensing with the dressedstates can be applicable for improving the sensitivity of aquantum sensing. As an example of a quantum application
using these results we propose a protocol of quantum sensing, which shows more than an order of magnitude enhancement in the sensitivity.

Figure 2. (Top) Pulse sequence to observe T2ρ and T2 with applying aphase cycle to the final π/2 pulse. (Bottom) Black and red plots show theresults of T2ρ and T2 measurements, respectively. They are fitted by exponential decay curves described by black and red solid lines.

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Division of Materials Chemistry– Nanospintronics –https://www.scl.kyoto-u.ac.jp/~onoweb/

Prof
ONO, Teruo(D Sc)

Assoc ProfSHIOTA, Yoichi(D Eng)Assist Prof
Program-Specific Assoc Prof Program-Specific Assist ProfHISATOMI, Ryusuke KARUBE, Shutaro
NARITA, Hideki(D Eng)(D Sc)(Ph D)

Students
KOBAYASHI, Yuta (D3)
JANG, Heechan (D3)KAWARAZAKI, Ryo (D2)KOMIYAMA, Haruka (D2)
TAGA, Kotaro (D2)

HAYASHI, Daiju (D2)
YE, Feifan (D2)SUGIURA, Itaru (D1)
TSENG, Chih-Hsiang (D1)
IIJIMA, Ryo (M2)

ITOH, Tomoya (M2)
SUGI, Koki (M2)
TAKAHASHI, Hiroyuki (M1)TOKORO, Fugo (M1)
MANDOKORO, Tetsuma (M1)

Scope of Research
Conventional electronics uses only the charge of electrons, while traditional magnetic devices use only the spin degreeof freedom of electrons. Aiming at complete control of both charge and spin in single solid-state devices, an emerging
field called spintronics is rapidly developing and having an impact on information technologies. By combining theatomic-­layer deposition with nanofabrication, we focus on the development of spin properties of various materials and thecontrol of quantum effects in mesoscopic systems for novel spintronics devices.

KEYWORDS
Spintronics
Magnetism
Magnetic Materials

Recent Selected Publications
Narita, H.; Ishizuka, J.; Kan, D.; Shimakawa, Y.; Yanase, Y.; Ono, T., Magnetization Control of Zero-Field Intrinsic Superconducting Diode
Effect, Adv. Mater., 35, 2304083 (2023).
Moriyama, T.; Sanchez-Tejerina, L.; Oda, K.; Ohkochi, T.; Kimata, M.; Shiota, Y.; Nojiri, H.; Finocchio, G.; Ono, T., Micromagnetic Understanding of Evolutions of Antiferromagnetic Domains in NiO, Phys. Rev. Mater., 7, 054401 (2023).
Hayashi, D.; Shiota, Y.; Ishibashi, M.; Hisatomi, R.; Moriyama, T.; Ono, T., Observation of Mode Splitting by Magnon-Magnon Coupling in
Synthetic Antiferromagnets, Appl. Phys. Express, 15, 053004 (2023).
Hisatomi, R.; Taga, K.; Sasaki, R.; Shiota, Y.; Moriyama, T.; Ono, T., Quantitative Optical Imaging Method for Surface Acoustic Waves Using
Optical Path Modulation, Phys. Rev. B, 107, 165416 (2023).
Ham, W. S.; Ho T. H.; Shiota, Y.; Iino, T.; Ando, F.; Ikebuchi, T.; Kotani, Y.; Nakamura, T.; Kan, D.; Shimakawa, Y.; Moriyama, T.; Im, E.; Lee,N. J.; Kim, K. W.; Hong, S. C.; Rhim, S. H.; Ono, T.; Kim, S., Generation of Spin-Polarized Electronic Currents Using Perpendicularly Magnetized
Cobalt Ferrite Spin-Filtering Barriers Grown on Spinel-Type-Conductive, Adv. Sci., 10, 2206800 (2023).

18

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Realization of the Field-Free Superconducting
Diode Effect
The diode effect is fundamental to electronic devices and is
widely used in rectifiers and AC–DC converters. At low temperatures, however, conventional semiconductor diodes possess a high resistivity, which yields energy loss and heating
during operation. The superconducting diode effect (SDE),
which relies on broken inversion symmetry in a superconductor may mitigate this obstacle: in one direction a zeroresistance supercurrent can flow through the diode, but for the
opposite direction of current flow, the device enters the normal state with ohmic resistance. The application of a magnetic
field can induce SDE in Nb/V/Ta superlattices with a polarstructure, in superconducting devices with asymmetric patterning of pinning centres, or in superconductor/ferromagnet
hybrid devices with induced vortices. The need for an external
magnetic field limits their practical application. Here, we present implementation of zero-field SDE using noncentrosymmetric [Nb/V/Co/V/Ta]20 multilayers. The magnetic layers
provide the necessary symmetry breaking and we can tune theSDE by adjusting the structural parameters, such as the constituent elements, film thickness, stacking order, and numberof repetitions. We control the polarity of the SDE through themagnetization direction of the ferromagnetic layers. Energyloss-free SDEs as presented in this work may therefore enable novel non-volatile memories and logic circuits with ultralow power consumption.

Spin-Transfer-Torque-Driven Magnetic
Domain Wall Motion in Antiferromagnetically
Coupled Ferrimagnets
Magnetic domain wall (DW) racetrack memory is anext-generation, non-volatile and high-density magnetic
memory, where the magnetic domain walls work as information bits and they are controlled by electric current via the effect of spin transfer torque (STT). However, to enhance thermal stability while keeping low driven current is difficult in
traditional domain wall (DW) motion devices. The increasingof energy barrier for thermal stability inevitably results in theenhancement of driven current. We numerically investigate
depinning field (Hdepin) and critical current density (Jc) for DW
motion as a function of uniaxial magnetic anisotropy (Ku) invertical DW motion memory with artificial ferromagnet. It isfound that Hdepin and Jc show different Ku dependence. The
results indicate that it is promising to simultaneously achieve
high thermal stability and low driven current in artificial ferromagnet based DW motion devices.

Figure 1. (a) Schematic of the SDE and measurement configuration. The magnetic field is applied perpendicular to both the polar axis and the electricalcurrent. (b) Non-volatile SDE at 1.9 K. Red and black dots represent the results for negative magnetization (-M) and positive magnetization (+M), respectively. Current densities J = 72.7 kA cm-2 and J = −72.7 kA cm-2 at 1.9 K without a magnetic field were repeatedly applied. The device shows asuperconducting state or normal conducting state depending on the polarity of the current. Note that the polarity of SDE depends on the direction ofmagnetization. The -M or +M state is achieved after sweeping the magnetic field in the order of +0.5, 0, −0.15, 0 T or −0.5, 0, +0.15, 0 T.

Figure 2. (a) Schematic illustration of the experimental setup. (b) The STT-induced DW velocity as a function of temperature. The dotted orange line
represents the angular momentum compensation temperature TA.

ICR ANNUAL REPORT, 2023

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Division of Biochemistry– Biofunctional Design-Chemistry –https://www.scl.kyoto-u.ac.jp/~bfdc/index.html

Prof
FUTAKI, Shiroh(D Pharm Sc)

Assoc ProfIMANISHI, Miki
(D Pharm Sc)

Assist Prof
Program-Specific Assoc Prof Program-Specific Assist Prof
KAWAGUCHI, Yoshimasa HIROSE, Hisaaki
KIMURA, Seigo(D Pharm Sc)(D Pharm Sc)(D Pharm Sc)

Students
IWATA, Takahiro (D3)KURIYAMA, Masashi (D2)MICHIBATA, Junya (D2)OTONARI, Kenko (D2)
IDA, Naka (D1)

NAKAGAWA, Yuna (D1)TANAKA, Kamui (D1)ASAMI, Yuri (M2)
IMAO, Keisuke (M2)TERADA, Sakahiro (M2)YOSHIE, Shunsuke (M2)
BABA, Nozomi (M1)
KASAHARA, Chisato (M1)
TAKEUCHI, Kosuke (M1)
UEHATA, Yusuke (M1)

YAMASAKI, Daisuke (M1)
KIKKAWA, Ayumi (UG)
NISHIJIMA, Hiroto (UG)
OBATA, Keito (UG)
KIYOKAWA, Megumi (RS)

Scope of Research
The ultimate goal of our research is the regulation of cellular functions by designed peptides and proteins. Currentr­ esearch subjects include (1) development of novel intracellular delivery systems aiming at elucidation and control ofcellular functions using designed membrane permeable peptide vectors, (2) elucidation of the DNA or RNA binding
modes of nucleic acid binding proteins, and design of artificial regulators of gene expression, (3) elucidation and controlof membrane curvature, and (4) design of stimulation-responsible artificial peptides and proteins.

KEYWORDS
Membrane-Permeable Peptides
Intracellular Delivery
Peptide Design
DNA/RNA Binding Protein
Membrane Curvature

Recent Selected Publications
Hirose H.; Nakata E.; Zhang Z.; Shibano Y.; Maekawa M.; Morii T.; Futaki, S., Macropinoscope: Real-Time Simultaneous Tracking of pH and
Cathepsin B Activity in Individual Macropinosomes, Anal. Chem., 95, 11410-11419 (2023).
Tanaka K.; Suda A.; Uesugi M.; Futaki S.; Imanishi M., Xanthine Derivatives Inhibit FTO in an L-ascorbic Acid-Dependent Manner, Chem.
Commun., 59, 10809-10812 (2023).
Omura M.; Morimoto K.; Araki Y.; Hirose H.; Kawaguchi Y.; Kitayama Y.; Goto Y.; Harada A.; Fujii I.; Takatani-Nakase T.; Futaki S.; Nakase I.,
Inkjet-Based Intracellular Delivery System that Effectively Utilizes Cell-Penetrating Peptides for Cytosolic Introduction of Biomacromolecules
through the Cell Membrane, ACS Appl. Mater Interfaces, 15, 47855-47865 (2023).
Nishimura M.; Kawaguchi Y.; Kuroki K.; Nakagawa Y.; Masuda T.; Sakai T.; Kawano K.; Hirose H.; Imanishi M.; Takatani-Nakase T.; AfoninS.; Ulrich A. S.; Futaki S., Structural Dissection of Epsin-1 N-Terminal Helical Peptide: The Role of Hydrophobic Residues in Modulating
Membrane Curvature, Chemistry, 29, e202300129 (2023).
Hirose H.; Maekawa M.; Ida H.; Kuriyama M.; Takahashi Y.; Futaki S., A Noncanonical Endocytic Pathway is Involved in the Internalizationof 3 μm Polystyrene Beads into HeLa Cells, Bioconjug. Chem., 33, 1851-1859 (2022).

20

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Development of a Dual Sensor to Track pH andan Enzyme Activity in Individual Macropinosomes
Macropinocytosis is an endocytic pathway that results in the formation of macropinosomes through massive uptake of extracellular
fluids. For instance, certain cancer cell types use macropinocytosis
to obtain extracellular nutrients, such as amino acids, to support
their proliferation. Furthermore, macropinocytosis represents apromising route for the effective delivery of biological macromolecules including proteins and antibodies. Nonetheless, acomprehensive understanding of the intracellular dynamics ofmacropinosomes has yet to be attained. Increased knowledge ofindividual macropinosomes behavior in living cells could significantly impact the design concept of drug delivery tools and development of drugs against cancer.
A fluorescent sensor that enables simultaneous analysis ofmultiple parameters in limited or specific cellular space is usefulfor comprehending molecular dynamics and biological responses
in living cells. In this study, we aimed to develop a macropinoscope, a fluorescent sensor that detects both pH and cathepsin B
activity in individual macropinosomes through fluorescencemicroscopy. Dextran (70 kDa) was utilized as a macropinosomespecific marker platform, onto which three fluorophores (fluorescein, Oregon Green, and tetramethylrhodamine) were loaded forratiometric pH sensing and imaging. Additionally, a cathepsinB-cleavable peptide sequence, bearing sulfo-Cy5 fluorophore andthe BHQ-3 quencher, was loaded onto the platform. The cathepsin
B activity can be detected by an increase in sulfo-Cy5 fluorescencewhen the peptide sequence is cleaved. The macropinoscope wasutilized to investigate the behavior of individual macropinosomes
produced by constitutive macropinocytosis in HT1080 cells. We
discovered that a sharp decrease in pH occurred close to the cell
nucleus, 5-10 minutes after macropinosome formation. We also
observed an immediate rise in cathepsin B activity as the pH of
the macropinosome reached around 6.
In the future, the sensor is expected to enable thorough examination of macropinosome behavior under other conditions and indifferent cell types. Additionally, our design concept will pave theway for the development of various macropinoscopes tailored toother parameters in individual macropinosomes.
Reference[1] Hirose, H. et al., Anal. Chem. 95, 11410-11419 (2023).

Inhibition of m6A Demethylation Activity of
FTO by Xanthine Derivatives with L-Ascorbic
Acid-Related Manner
Chemical modifications of RNA play an important role in gene
regulation. In particular, N6-methyladenosine (m6A), which ispresent in transcripts at high frequency, is involved in development and differentiation as well as various diseases. Despite theincreasing evidence of the importance of m6A RNA methylation,
convenient m6A detection methods for measuring the activity ofRNA methyltransferases and demethylases and for screening
their inhibitors have been lacking. Here, a simple method todetect the methylation states of RNA was constructed using the
Escherichia coli RNA endonuclease MazF, which we found to be
m6A-sensitive, in combination with the FRET probe containing
an m6A consensus RNA sequence. We searched for inhibitors ofthe m6A demethylase FTO, one of the member of Fe(II) and 2oxoglutarate-dependent oxygenases. Xanthine derivatives wereidentified as specific inhibitors of the m6A demethylase activity of
FTO. These inhibitors exhibited L-ascorbic acid concentrationdependent inhibitory activity against FTO, an unprecedented
mode of inhibition. Our results have significant implications forunderstanding the regulatory mechanisms of FTO and the designof FTO-specific inhibitors.
Reference[2] Tanaka, K. et al., Chem. Commun. 59, 10809-10812 (2023).

Figure 2. An activity-based screening for FTO inhibitor identified xanthine derivatives as specific inhibitor with an L-ascorbic acid-dependent
mode of inhibition. Reprinted from [2].

Figure 1. Macropinoscope can track dual parameters (pH and cathepsin B
activity) of individual macropinosomes by fluorescence microscopy. Reprinted from [1].

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Division of Biochemistry– Chemistry of Molecular Biocatalysts –https://www.scl.kyoto-u.ac.jp/~plant/index.html

Prof
Assist ProfYAMAGUCHI, Shinjiro MASHIGUCHI, Kiyoshi(D Agr)(D Agr)Guest Scholar*
LI, Heqin(Ph D)*Qingdao Agricultural University,
China, 1 November 2022–31
October 2023

Students
IMURA, Naohiro (M2)
SHIBATA, Ryosuke (M2)

WATANABE, Yuya (M2)
JIANG, Yue (M1)

Scope of Research
Plant hormones are a group of small molecules that are synthesized by plants and control their growth, development
and environmental responses. This laboratory aims at elucidating how plant hormones are made and act in plants. Towards
this goal, we combine chemical (organic chemistry, biochemistry, and analytical chemistry) and biological (molecular
genetics, physiology, molecular biology, genomics) approaches. We are also looking for new hormone-like compounds byusing mutant plants that show morphological phenotypes.

KEYWORDS
Plant Hormone
Strigolactone
Biosynthesis
Cytochrome P450
Receptor

Recent Selected Publications
Mashiguchi, K.; Morita, R.; Tanaka, K.; Kodama, K.; Kameoka, H.; Kyozuka, J.; Seto, Y.; Yamaguchi, S., Activation of Strigolactone Biosynthesisby the DWARF14-LIKE/KARRIKIN-INSENSITIVE2 Pathway in Mycorrhizal Angiosperms, but Not in Arabidopsis, a Non-Mycorrhizal
Plant, Plant Cell Physiol., 64, 1066-1078 (2023).
Cui, J.; Nishide, N.; Mashiguchi, K.; Kuroha, K.; Miya, M.; Sugimoto, K.; Itoh, J.-I.; Yamaguchi, S.; Izawa, T., Fertilization Controls Tiller
Numbers via Transcriptional Regulation of a MAX1-like Gene in Rice Cultivation, Nat. Commun., 14, 3191 (2023).
Mashiguchi, K.; Seto, Y.; Onozuka, Y.; Suzuki, S.; Takemoto, K.; Wang, Y.; Dong, L.; Asami, K.; Noda, R.; Kisugi, T.; Kitaoka, N.; Akiyama,K.; Bouwmeester, H.; Yamaguchi, S., A Carlactonoic Acid Methyltransferase That Contributes to the Inhibition of Shoot Branching in
Arabidopsis, Proc. Natl. Acad. Sci. U.S.A., 119(14), e2111565119 (2022).
Ishida, T.; Watanabe, B.; Mashiguchi, K.; Yamaguchi, S., Synthesis and Structure-Activity Relationship of 16,17-Modified Gibberellin
Derivatives, Phytochem Lett., 49, 162-166 (2022).
Mashiguchi, K.; Seto, Y.; Yamaguchi, S., Strigolactone Biosynthesis, Transport and Perception, Plant J., 105, 335-350 (2021).

22

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
The Mechanism for Strigolactone Perception
and Deactivation by a DWARF14 Receptor
Strigolactones (SLs) have been identified as root-­derived
signals for parasitic and symbiotic interactions in the rhizosphere. In addition to these functions as allelochemicals,
SLs are now known as endogenous plant hormones that
regulate many aspects of plant growth such as outgrowth ofaxillary shoots, root development and leaf senescence.
Recently, the perception mechanism for SLs has been asubject of debate because their receptor, DWARF14 (D14),
is an α/β-hydrolase that can cleave SLs. In the study of
Seto et al. (2019), we first conducted time-course analyses
of SL binding and hydrolysis by Arabidopsis D14 (AtD14)
by using differential scanning fluorimetry (DSF) experiments and hydrolysis assays (Figure 1). In these analyses,
we found that the level of uncleaved GR24, a synthetic
SL analog, strongly correlates with the induction of themelting temperature (Tm) shift of AtD14, suggesting that
SLs trigger the active state of D14 before their hydrolysis.

Figure 2. Functional analysis of the AtD14D218A mutant. (A) The SL hydrolysis activities of maltose binding protein (MBP)-tagged wild-type of
AtD14 protein (AtD14WT) and the AtD14D218A mutant. MBP was used in
the control reaction. (B) The branching phenotype of Arabidopsis transgenic plants expressing AtD14WT and AtD14D218A. (C) The SL-dependentinteraction of SMXL7 with AtD14WT and AtD14D218A in yeast.

Moreover, we showed that overexpression of the­AtD14R183H mutant, which could not interact with SMXL7
in the presence of SLs, but could hydrolyze SLs like
­AtD14WT, resulted in an increased shoot branching phenotype (data not shown). These results support the idea thatthe hydrolase reaction catalyzed by D14 would be a deactivating step of SLs after transducing the signal.
From these lines of evidence, we conclude that the intact
SL molecules trigger the D14 active signaling state, andthat D14 deactivates bioactive SLs by hydrolysis after signal transmission. Together, our results revealed that D14 isa dual-functional receptor, responsible for both the perception and deactivation of bioactive SLs (Figure 3).

Figure 1. The time-course analyses of SL binding and hydrolysis by
AtD14. (A) Hydrolysis reaction of SL (GR24) by AtD14. (B) Quantification of the hydrolysis reaction of GR24 (40 μM) by AtD14. (C) The Tm
shift of AtD14 incubated with GR24 (40 μM) in DSF analysis. The maximum Tm shift was observed at initial incubation (0 min).

We next analyzed the catalytic triad mutants of AtD14.
Among them, interestingly, the AtD14D218A mutant completely complemented the hyper-branching phenotype of
the atd14 mutant though it lacks the hydrolase activity(Figure 2). Moreover, we found that the AtD14D218A mutant
could interact with SMXL7, a negative regulator of SL
signaling, in an SL-dependent manner in yeast two hybrid experiments (Figure 2). These findings suggest thatthe hydrolase reaction catalyzed by D14 is not necessary
for the signal transducing role.

Figure 3. A proposed model of D14 in SL signaling. Bioactive SLs induce
the conformational changes of D14, which triggers complex formation
with the signaling partners. After the degradation of negative regulators of
SL signaling (D53/SMXLs) and transmission of the SL signal, D14 reconstructs the catalytic triad to inactivate the bioactive SL.

ICR ANNUAL REPORT, 2023

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Division of Biochemistry– Molecular Biology –https://www.scl.kyoto-u.ac.jp/~molbio/index.html

Prof
AOYAMA, Takashi(D Sc)

Assoc ProfTSUGE, Tomohiko(D Sc)

Assist Prof
KATO, Mariko(D Agr)Students
HAGHIR, Shahrzad (D3)ODOI, Miku (D1)

Guest Scholars
RUBIO, Vicente (Ph D)
Centro Nacional de Biotecnologia, CSIC, Spain, 6 October 2023–14 October 2023
GALBIATI, Massimo (Ph D)	Institute of Agricultural Biology and Biotechnology, CNR, Italy, 17 November 2023–
28 November 2023

Scope of ResearchThis laboratory aims at clarifying molecular bases of regulatory mechanisms for plant development, especially plantmorphogenesis, with techniques of forward and reverse genetics, molecular biology, and biochemistry. Current major
subjects are: 1) phospholipid signaling in cell morphogenesis, 2) transcriptional network for cell morphogenesis, 3)
COP9 signalosome modulating signal transduction in the nuclei, and 4) RNA processing mediated gene expression
regulation.

KEYWORDS
Morphogenesis
Phospholipid Signaling
mRNA Processing

Signal Transduction
COP9 Signalosome

Recent Selected Publications
Kato, M.; Watari, M.; Tsuge, T.; Zhong, S.; Gu, H.; Qu, L.-J.; Fujiwara, T.; Aoyama, T., Redundant Function of the Arabidopsis Phosphatidylinositol
4-Phosphate 5-Kinase Genes PIP5K4-6 is Essential for Pollen Germination, Plant J., (in press).
Akagi, C.; Kurihara, Y.; Makita, Y.; Kawaguchi, M.; Tsuge, T.; Aoyama, T.; Matsui, M., Transcriptional Activation of Ribosome-Related Genesat Initial Photoreception is Dependent on Signals Derived from Both the Nucleus Ans the Chloroplants in Arabidopsis thaliana, J. Plant Res.,
136, 227-238 (2023).
Watari, M.; Kato, M.; Blanc-Mathieu, R.; Tsuge, T.; Ogata, H.; Aoyama, T., Functional Differentiation among the Arabidopsis Phosphatidylinositol
4-Phosphate 5-Kinase Genes PIP5K1, PIP5K2 and PIP5K3, Plant Cell Physiol., 63, 635-648 (2022).
Zhang, X.; Nomoto, M.; Garcia-León, M.; Takahashi, N.; Kato, M.; Yura, K.; Umeda, M.; Rubio, V.; Tada, Y.; Furumoto, T.; Aoyama, T.; Tsuge,T., CFI 25 Subunit of Cleavage Factor I is Important for Maintaining the Diversity of 3ʹ UTR Lengths in Arabidopsis thaliana (L.) Heynh, Plant
Cell Physiol., 63, 369-383 (2022).

24

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Redundant Function of the Arabidopsis
PIP5K Genes for Pollen Germination
Pollen is the male gametophyte with a functional structure for transferring sperm cells to the egg apparatus inseed plants. Pollen undergoes unique cell biological processes of pollen development to support its structural development and functional performance. After pollination, apollen grain first establishes a cell polarity focusing on the
future germination site, and then, a pollen tube germinatesand elongates through tip growth toward the embryo sac
according to a series of guidance signals. Although thesecomplicated processes accurately progress, underlying
regulatory mechanisms remain largely elusive, especiallyfor the germination process involving the cell polarity.
Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2],
one of phosphoinositides serving as a signaling moleculein eukaryotic cells is localized mainly to the plasma membrane frequently with a polarized pattern. Through thefunctions of its interacting proteins, PtdIns(4,5)P2 regulates
various cell biological processes, including cytoskeletalorganization, membrane trafficking, and signal transduction
for gene expression. While the metabolic pathways ofphosphoinositides link together to form a complicatednetwork, the phosphorylation of PtdIns(4)P by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) is thought to bea key pathway responsible for the production of PtdIns(4,5)
P2 in higher plants, where some of the phosphoinositide

Figure 1. Subcellular localization of YFP-fused PIP5K4–6 proteins prior
to pollen germination. (A) Bright field (left) and YFP fluorescence (right)
images of pollen grains expressing PIP5K4-YFP, PIP5K5-YFP, and
PIP5K6-YFP prior to pollen germination are shown. (B) Bright field (left)
and YFP fluorescence (middle) images, and index-color images of YFP
fluorescence (right) of pollen grains expressing PIP5K6-YFP prior to pollen
germination are shown. Arrows on bright field images in (A) indicate
pollen apertures. Scale bars: 10 μm.

metabolic pathways found in animals or fungi are missing.
Among the 11 PIP5K genes of Arabidopsis thaliana,
PIP5K4, PIP5K5, and PIP5K6 have been intensively
studied on their functions in pollen tube growth, andstrongly suggested to have an indispensable function for
the elaborate pollen system of angiosperms. However, thisidea remains to be verified, mainly because comprehensive
genetic analysis of the genes using their loss-of-function
mutants has not been done. We performed a comprehensive
genetic analysis of the genes and revealed that their redundant function is essential for pollen germination. Pollen
with the pip5k4pip5k5pip5k6 triple mutation was sterile.
PIP5K4-YFP, PIP5K5-YFP, and PIP5K6-YFP, which
could rescue the sterility of the triple mutant pollen, preferentially localized to the tricolpate aperture area and thefuture germination site on the plasma membrane prior togermination (Figure 1). Triple mutant pollen grains under
the germination condition, in which spatiotemporal localization of the PtdIns(4,5)P2 fluorescent marker protein
2xmCHERRY-2xPHPLC as seen in the wild type was abolished (Figure 2), exhibited swelling and rupture of the pollen wall, but neither the conspicuous protruding site norsite-specific deposition of cell wall materials for germination. These data indicate that PIP5K4–6 and their product
PtdIns(4,5)P2 are essential for pollen germination, possibly
through the establishment of the germination polarity in apollen grain.

Figure 2. Subcellular localization of PtdIns(4,5)P2 marker protein and
PIP5K6-YFP in the pip5k4-pip5k5-pip5k6- pollen. Pollen grains fromtransgenic plants heterozygously and homozygously containing PIP5K6pPIP5K6-YFP and UBQ10p-2xmCHERRY-2xPHPLC, respectively, in the
pip5k4pip5k5pip5k6 background were untreated (A) or treated (B) with
pollen germination medium. Fluorescence images of PIP5K6-YFP(left) and 2xmCHERRY-2xPHPLC (second left), merged images (secondright), and bright field images (right) are shown. Asterisks indicate
pip5k4pip5k5pip5k6 pollen grains without the PIP5K6p-PIP5K6-YFP
transgene. Scale bars: 10 μm.

ICR ANNUAL REPORT, 2023

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Division of Biochemistry– Chemical Biology –https://www.scl.kyoto-u.ac.jp/~uesugi/

Prof
UESUGI, Motonari(D Pharm Sc)

Assoc Prof
SATO, Shinichi(D Eng)Senior Lect
PERRON, Amelie(Ph D)

Assist ProfTAKEMOTO, Yasushi(D Eng)Assist Prof
ABO, Masahiro(D Pharm Sc)

Students
Program-Specific Assist ProfPD
JIN, Shuyu
TAKEMOTO, Misao(D Med)(D Eng)SINGH, Vaibhav Pal (D4)
TOH, Kohei (D4)FARRAG, Asmaa Mostafa
Abdelbari Soliman (D2)TSERENDAGVA, Manchir (D1)

TRAN, Chi Mai (M2)
PIAO, Canguo (M2)
ZHANG, Yixin (M2)
HELMS, Melanie (M1)
LATOS, Krystian (RS)Guest Res Assoc
KIM, Hyosuk (Ph D)

Yonsei University, Republic of Korea, 1 April 2023–31 March 2024

Scope of Research
Chemical biology is an interdisciplinary field of study that is often defined as “chemistry-initiated biology.” As biological processes all stem from chemical events, it should be possible to understand or manipulate biological events usingchemistry. Our laboratory has been discovering or designing unique organic molecules that modulate fundamental processes in human cells. Such synthetic organic molecules often serve as tools for basic cell biology. Discovery or design ofsmall molecules with unique biological activities permits small-molecule-initiated exploration of complex cellular events.
Our mission is to create a new world of bioactive synthetic
molecules: new modes of activity, new shapes, and new sizes.
KEYWORDS
We hope that these basic studies open new avenues for
Chemical Biology
Self-Assembly
Chemical Librarysmall-molecule applications in a range of fields.
Chemical Genetics

Immunology

Recent Selected Publications
Perron, A.; Mandal, S.; Chuba, T.; Mao, D.; Singh, V.; Noda, N.; Tan, R.; Vu, H.; Abo, M.; Uesugi, M., Small-Molecule Drug Repurposing forCounteracting Phototoxic A2E Aggregation, ACS Chem. Biol., 18(10), 2170-2175 (2023).
Zhuo, S.; Noda, N.; Hioki, K.; Jin, S.; Hayashi, T.; Hiraga, K.; Momose, H.; Li, W.; Zhao, L.; Mizukami, T.; Ishii, K.; Li, Y.; Uesugi, M.,
Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile, J. Med. Chem., 66(18),13266-13279 (2023).
Toh, K.; Nishio, K.; Nakagawa, R.; Egoshi, S.; Abo, M.; Perron, A.; Sato, S.; Okumura, N.; Koizumi, N.; Dodo, K.; Sodeoka, M.; Uesugi, M.,
Chemoproteomic Identification of Blue-Light-Damaged Proteins, J. Am. Chem. Soc., 144, 20171-20176 (2022).
Jin, S.; Zhuo, S.; Takemoto, Y.; Li, Y.; Uesugi, M., Self-Assembling Small-Molecule Adjuvants as Antigen Nano-Carriers, Chem Commun., 58,
12228-12231 (2022).
Nishio, K.; Toh, K.; Perron, A.; Goto, M.; Abo, M.; Shimakawa, Y.; Uesugi, M., Magnetic Control of Cells by Chemical Fabrication of Melanin,
J. Am. Chem. Soc., 144, 16720-16725 (2022).

26

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Small-Molecule Drug Repurposing for Counteracting Phototoxic A2E Aggregation
Despite the well-established role of oxidative stress inthe pathogenesis of age-related macular degeneration(AMD), the mechanism underlying phototoxicity remains
unclear. The Uesugi group used a drug repurposing approach
to isolate an FDA-approved drug that blocks the aggregation of the photoinducible major fluorophore of lipofuscin,
the bis-retinoid N-retinylidene-N-retinylethanolamine(A2E). Their fluorescence-based screening combined withdynamic light scattering (DLS) analysis led to the identification of entacapone as a potent inhibitor of A2E
fluorescence and aggregation. The entacapone-mediatedinhibition of A2E aggregation blocks its photodegradationand offers photoprotection in A2E-loaded retinal pigment
epithelial (RPE) cells exposed to blue light. In-depth
mechanistic analysis suggests that entacapone prevents theconversion of toxic aggregates by redirecting A2E into
off-pathway oligomers. These findings provide evidence
that aggregation contributes to the phototoxicity of A2E.

Identification of a Self-Assembling
Small-Molecule Cancer Vaccine Adjuvantwith an Improved Toxicity Profile
Protein or peptide cancer vaccines usually include immune potentiators, so-called adjuvants. However, it remains challenging to identify structurally simple, chemically accessible synthetic molecules that are effective andsafe as vaccine adjuvant. The Uesugi group discoveredcholicamideβ (6), a self-assembling small-molecule vaccine adjuvant with an improved toxicity profile and provenefficacy in vivo. The Uesugi group and their collaborators
demonstrated that cholicamideβ (6), which is less cytotoxic than its parent compound, forms virus-like particles topotently activate dendritic cells with the concomitant secretion of cytokines. When combined with a peptide antigen, cholicamideβ (6) potentiated the antigen presentation
on dendritic cells to induce antigen-specific T cells. As atherapeutic cancer vaccine adjuvant in mice, a mixture ofcholicamideβ (6) and a peptide antigen protected micefrom the challenges of malignant cancer cells without overt
toxicity. Cholicamideβ (6) may offer a translational opportunity as an unprecedented class of small-molecule cancer
vaccine adjuvants.

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Division of Environmental Chemistry– Molecular Materials Chemistry –http://molmat.kuicr.kyoto-u.ac.jp/index-e.html

Prof
KAJI, Hironori(D Eng)Assist Prof
Assist Prof
Program-Specific Assoc ProfSHIZU, Katsuyuki
SUZUKI, Katsuaki
TANAKA, Hiroyuki(D Eng)(D Human & Envirnmtl. Studies)(D Sc)

Techn Staff
MAENO, Ayaka

Students

Techn Staff
NAKAJIMA,Yuuki

REN, Yongxia (D4)KUSAKABE, Yu (D3)MURAKAMI, Kimiya (D2)FUJINAKA, Masatoshi (D2)
SATO, Hiroki (D1)ISHIHARA, Kuraudo (M2)

OKUMURA, Kazuki (M2)
OKUMURA, Ryosuke (M2)
ONOE, Renon (M1)
YASUDA, Yuka (M1)
FUKUSHIMA, Shohei (M1)
KAWABATA, Kazuhiro (UG)

Scope of Research
Our research goal is to develop high-performance or­
ganic electroluminescence devices, organic solar cells, andpolymer materials. Toward this, we carry out syntheses,
device fabrications, precise structure characterizations, andquantum chemical calculations for high functional organic
materials. Along with exploring novel synthetic routes andnovel devices, we perform detailed analyses of structuresand dynamics, mainly by sophisticated solid-state NMR
spectroscopy, in order to obtain structure–dynamics–­
property relationships.

KEYWORDS
Organic Light-Emitting Diodes
Solid-State NMR
Quantum Chemical Calculation
Amorphous Materials
Dynamic Nuclear Polarization Enhanced NMR

Recent Selected Publications
Shizu, K.; Ren, Y.; Kaji, H., Promoting Reverse Intersystem Crossing in Thermally Activated Delayed Fluorescence via the Heavy-AtomEffect, J. Phys. Chem. A, 127, 439-449 (2023).
Tanaka, H.; Mizuhata, Y.; Tokitoh, N.; Miyamoto, R.; Kanamori, K.; Kaji, H., Multiple Stimuli-Responsive Supramolecular Organic Framework
under Concomitant Emission Color Changes, J. Phys. Chem. C, 127, 20459-20465 (2023).
Suzuki, K.; Kaji, H., Torsion Angle Analysis of a Thermally Activated Delayed Fluorescence Emitter in an Amorphous State Using Dynamic
Nuclear Polarization Enhanced Solid-State NMR, J. Am. Chem. Soc., 145, 16324-16329 (2023).

28

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Promoting Reverse Intersystem Crossing in
Thermally Activated Delayed Fluorescence
via the Heavy-Atom Effect
Fast reverse intersystem crossing (RISC) in thermally
activated delayed fluorescence (TADF) is an effective
approach to improving the device lifetime of organic
light-emitting diodes. In this study, we reported theheavy-atom effect on TADF and a molecular design for
accelerating RISC. We reproduced all the relevant rate
constants of a sulfur-containing molecule (kRISC of 108 s−1)
using density functional theory and revealed the role of theheavy-atom effect on the rapid RISC. Then, we predictedmuch larger kRISC (>1010 s−1) for selenium- and telluriumcontaining molecules. We also predicted that a poloniumcontaining molecule would promote phosphorescence
without exhibiting TADF, indicating that a too strong
heavy-atom effect is disadvantageous for achieving both
rapid RISC and efficient TADF. A moderate heavy-atom
effect was found to be essential for fast RISC in TADF.

Figure 1. Promoting Reverse Intersystem Crossing in Thermally Activated
Delayed Fluorescence.

Torsion Angle Analysis of a Thermally
Activated Delayed Fluorescence Emitter inan Amorphous State Using Dynamic Nuclear
Polarization Enhanced Solid-State NMR
The torsion angle between donor and acceptor segmentsof a thermally activated delayed fluorescence (TADF)
molecule is one of the most critical factors in determining
the performance of TADF-based organic light-emitting
diodes (OLEDs) because the torsion angle affects not only
the energy gap between the singlet and triplet but also theoscillator strength and spin–orbit coupling. However, thetorsion angle is difficult to analyze, because organic molecules are in an amorphous state in OLEDs. Here, we determined the torsion angle of a highly efficient TADF emitter,
DACT-II, in an amorphous state by dynamic nuclear
polarization-enhanced solid-state NMR measurements. Fromthe experimentally obtained chemical shift principal valuesof 15N on carbazole, we determined the average torsion
angle to be 52°. Such quantification of the torsion angles in
TADF molecules in amorphous solids will provide deep
insight into the TADF mechanism in amorphous OLEDs.

Figure 2. Torsion angle analysis of TADF emitter by DNP-NMR.

Multiple Stimuli-Responsive Supramolecular
Organic Framework under Concomitant
Emission Color Changes
A stimuli-responsive luminophore embedding an
overcrowd-ed bistricyclic aromatic ene structure with aheptagon=hexagon central ring, DCHA-TRZ, has been
designed and synthesized. In a single-crystalline solid,
DCHA-TRZ constructed a supramolecular organic framework (SOF) including n-hexane molecules as a guest molecule. The crystalline SOF (α phase) exhibited reversible
crystalline (α)-to-amorphous-to-crystalline (α) solid-statephase transitions triggered by external stimuli of mechanicalgrinding and treatment with a n-hexane solvent, in which
release and inclusion of the guest molecules played an
important role. Moreover, the thermal annealing of theamorphous ground solid afforded a bluish green-emitting
solid with a different crystalline phase (β). The combinationof the three external stimuli of the mechanical grinding,thermal annealing and solvent treatment enables the reversible and cyclical phase transitions among three solidstate phases (crystalline α, β and amorphous) under concomitant emission color changes.

Figure 3. Multiple stimuli-responsive SOF under concomitant emission
color changes on the mortar.

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Division of Environmental Chemistry– Hydrospheric Environment Analytical Chemistry –https://inter3.kuicr.kyoto-u.ac.jp/scope_E.html

Prof
SOHRIN, Yoshiki(D Sc)

Students
UEKI, Ryuta (D3)
CHAN, Cheuk-Yin (D3)MATSUOKA, Kohei (D1)Assist Prof
TAKANO, Shotaro(D Sc)

Assist ProfZHENG, Linjie(D Sc)

Techn Staff
IWASE, Misato

Guest Scholar*
CAI, Pinghe(Ph D)*Department of Marine
Chemistry and Geo­chemistry, Xiamen University, China, 19 August
2022–31 July 2023

KAKIMOTO, Ryochi (M1)YUNOKI, Keisuke (M1)

Guest Res Assoc
HSIEH, Chih-Chiang (Ph D)	Research Center for Environmental Changes, Academia Sinica, Taiwan, 27 September
2023–26 October 2023
HO, Yi-Ning	Institute of Oceanography, National Taiwan University, Taiwan, 27 September 2023–26
October 2023

Scope of Research(i) Biogeochemistry of trace elements in the hydrosphere: Novel analytical methods are developed for trace metals
and their isotopes. Distribution of trace elements in the hydrosphere and their effects on the ecosystem are investigated.
The study also covers hydrothermal activity, deep biosphere, and paleocean. (ii) Ion recognition: Novel ligands and ion
recognition system are designed, synthesized, and characterized.

KEYWORDS
Marine Chemistry
Stable Isotopes

Analytical Chemistry
Metal Ion Recognition

Trace Elements

Recent Selected Publications
Ueki, R.; Zheng, L.; Takano, S.; Sohrin, Y., Distributions of Zirconium, Niobium, Hafnium, and Tantalum in the Subarctic North Pacific Ocean
Revisited with a Refined Analytical Method, Geochem J., 57, 143-154 (2023).
Matsuoka, K.; Tatsuyama, T.; Takano, S.; Sohrin, Y., Distribution of Stable Isotopes of Mo and W from a River to the Ocean: Signatures of
Anthropogenic Pollution, Front. Mar. Sci., 10 (2023).
Sieber, M.; Lanning, N. T.; Bian, X.; Yang, S.-C.; Takano, S.; Sohrin, Y.; Weber, T. S.; Fitzsimmons, J. N.; John, S. G.; Conway, T. M., The
Importance of Reversible Scavenging for the Marine Zn Cycle Evidenced by the Distribution of Zinc and Its Isotopes in the Pacific Ocean, J.
Geophys. Res.: Oceans, 128 (2023).
Alam, M.; Muguli, T.; Gurumurthy, G. P.; Arif, M.; Sohrin, Y.; Singh, A. D.; Radhakrishna, T.; Pandey, D. K.; Verma, K., Hydroclimatic Conditions
and Sediment Provenance in the Northeastern Arabian Sea since the Late Miocene: Insights from Geochemical and Environmental Magnetic
Records at IODP Site U1457 of the Laxmi Basin, Geol Mag., 160, 813-829 (2023).
Iwase, M.; Isobe, K.; Zheng, L.; Takano, S.; Sohrin, Y., Solid-Phase Extraction of Palladium, Platinum, and Gold from Water Samples: Comparison
between a Chelating Resin and a Chelating Fiber with Ethylenediamine Groups, Anal. Sci, 39, 695-704 (2023).

30

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Distribution of Stable Isotopes of Mo and W
from a River to the Ocean: Signatures of
Anthropogenic Pollution
Molybdenum (Mo) and tungsten (W) are redox-sensitiveelements, and their stable isotope ratios have attracted
attention as paleoceanographic proxies. However, ourknowledge of the distribution of stable Mo and W isotopes
in the modern hydrosphere remains limited. In this study,
we provided the concentrations and isotope ratios of dissolved Mo and W in the oceans (the North Pacific andIndian Oceans), marginal seas (East China and the Sea ofJapan), and a river-estuary system in Japan (from the
Uji-Yodo rivers to Osaka Bay). In the North Pacific andIndian Oceans, the W concentration was 48.2 ± 6.2 pmol/kg (ave ± 2sd, n = 109), δ186/184W was 0.52 ± 0.06 ‰, theMo concentration was 105.1 ± 8.0 nmol/kg, and δ98/95Mo
was 2.40 ± 0.06 ‰. The results indicate that W has theconstant concentration and isotopic composition in themodern ocean as well as Mo. In the East China Sea andthe Sea of Japan, the W concentration and δ186/184W in theupper water (< 1000 m depth) were different from those in
the ocean (W = 56 ± 18 pmol/kg, δ186/184W = 0.45 ± 0.06‰, n = 24). However, the concentrations in deeper water
were congruent with those in the oceans (W = 49.9 ± 7.6
pmol/kg, δ186/184W = 0.50 ± 0.02 ‰, n = 7). The Mo concentration was 105.4 ± 3.1 nmol/kg and δ98/95Mo was 2.36
± 0.03 ‰ (n = 31) throughout the water column, congruent
with those in the ocean. In the Uji River-Yodo River-Osaka
Bay system, the W concentration reached 1074 pmol/kg
and δ186/184W reached 0.20 ‰. We propose that the enrichment of W with a low δ186/184W in the river-estuary system
and marginal seas is caused by anthropogenic pollution.
Anthropogenic Mo pollution was not detected in marginalseas. However, the Mo concentration and δ98/95Mo showed
high anomalies above the mixing line of river water andseawater in the lower Yodo River and Osaka Bay, implying
possible anthropogenic pollution of Mo in the metropolitan
area.

Distributions of Zirconium, Niobium, Hafnium,
and Tantalum in the Subarctic North Pacific
Ocean Revisited with a Refined Analytical
MethodAlthough zirconium (Zr), niobium (Nb), hafnium (Hf),and tantalum (Ta) in seawater are potential tracers for water
masses, their determination is still a challenge in analyticalchemistry. We have refined our preconcentration method
using 8-hydroxyquinoline chelating resin (TSK-8HQ) andreinvestigated concentration profiles of the four elements
in dissolved (d) and total dissolvable (td) fractions at fivedifferent stations from 47 °N, 160 °E to 51 °N, 160 °W in
the subarctic North Pacific Ocean. The new method has
saved analytical time and reduced systematic errors compared with previous methods. The concentration ranges
were 30 – 276 pmol/kg for dZr, 1.0 – 2.6 pmol/kg for dNb,
0.09 – 0.78 pmol/kg for dHf, and 0.006 – 0.026 pmol/kg
for dTa in the subarctic North Pacific Ocean. The concentrations of Zr and Hf increased from surface water to deep
water, whereas those of Nb and Ta were nearly constantover the water depth. The profiles of dZr, dNb, and dHf
were consistent with those in previous studies. However,
we found that dTa is uniformly distributed at 0.015 ± 0.005
pmol/kg (mean ± sd, n = 75), which is approximately onefifth of that in a previous study. It is likely that the previous
dTa data were affected by a systematic error. Negligible
differences between td and d fractions suggest that the particulate concentrations of these elements are lower thanthose reported in a previous study.

Figure 2. Graphical abstract of this study.

Figure 1. Sampling stations of this study: A, global map; B, map of theUji River-Yodo River-Osaka Bay system.

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Division of Environmental Chemistry– Chemistry for Functionalized Surfaces –https://www.scl.kyoto-u.ac.jp/~yoeki/

Prof
HASEGAWA, Takeshi(D Sc)

Assoc Prof
MORI, Taizo(D Eng)Assist ProfSHIOYA, Nobutaka(D Sc)

Program-Specific Res
KUROSE, Noriko(D Eng)Students
OKA, Takayuki (M2)
SAKO, Nobuaki (M2)
ARAKI, Taisuke (M1)
SUGIMOTO, Emi (M1)

Scope of Research
To understand the chemical structure and properties of a molecular aggregatedsystem, the keywords of molecular interactions and orientation are focused on, andthe molecular aggregates are investigated by using originally developed spectroscopic techniques. The current major topics are: (1) perfluoroalkyl-specific properties in a condensed system; (2) controlling factors of molecular packing and­orientation in a thin film of an organic semiconductor compound; (3) developmentof new molecular orientation analytical technique “MAIRS2.”KEYWORDS
Infrared and Raman Spectroscopy
Surface and Interface Chemistry
Perfluoroalkyl Compounds
Organic Semiconductors
pMAIRS and MAIRS2

Recent Selected Publications
Shimoaka, T.; Yamaguchi, Y.; Shioya, N.; Ajayaghosh, A.; Mori, T.; Ariga, K.; Hasegawa, T., Insights on the Molecular Orientation of
Oligo(p-Phenylene Vinylene) Derivatives with Alkyl Chains in Langmuir Films, J. Phys. Chem. C., 127, 9336-9343 (2023).
Oka, T.; Shioya, N.; Shimoaka, T.; Hasegawa, T., Structural Rearrangement of Organic Semiconductor Molecules with an Asymmetric Shapein Thin Films, J. Phys. Chem. C., 127, 7560-7564 (2023).
Shioya, N.; Yoshida, M.; Fujii, M.; Shimoaka, T.; Miura, R.; Maruyama, S.; Hasegawa, T., Conformational Change of Alkyl Chains at Phase
Transitions in Thin Films of an Asymmetric Benzothienothiophene Derivative, J. Phys. Chem. Lett., 13, 11918-11924 (2022).
Shioya N.; Fujii M.; Shimoaka T.; Eda K.; Hasegawa T., Stereoisomer-Dependent Conversion of Dinaphthothienothiophene Precursor Films,
Sci. Rep., 12, 4448 (2022).
Tomita K.; Shioya N.; Shimoaka T.; Wakioka M.; Hasegawa T., Control of Supramolecular Organizations by Coordination Bonding in
Tetrapyridylporphyrin Thin Films, Chem. Commun., 58, 2116-2119 (2022).

32

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Insights on the Molecular Orientation of
Oligo(p‑Phenylene Vinylene) Derivatives with
Alkyl Chains in Langmuir Films

work highlights the importance of using IR spectroscopy
with a high-wavenumber resolution for structural analysis
of molecular thin films.

One of the oligo(p-Phenylene Vinylene) derivatives
having alkyl chains, OPV-1, is known to form rod-shaped
nanoaggregates on the water surface, and thin films withaligned nanoaggregates can be obtained by the Langmuir–
Blodgett (LB) technique. Although the molecular aggregation and orientation of the “conjugated rings part” in the
LB films have already been investigated, analysis of thedetailed molecular structure involving the “alkyl chains” isleft behind. In the present study, to reveal the role of thealkyl chains in the molecular aggregation in Langmuirfilms prior to the LB transfer, infrared (IR) external reflection spectroscopic measurements on the water surface arecarried out. It has been revealed that not only the conjugatedrings of OPV-1 but also the alkyl chains with an ordered
conformation are lying on the water surface. In addition,
the orientation is found to be kept on a solid substrateeven after the LB transfer by IR p-polarized multiple-angle
incidence resolution spectrometry.

Figure 2. Structural rearrangement of Ph-BTBT-C10 from the thin-filmphase to the bulk phase revealed by IR spectroscopy.

Figure 1. Lying orientation of oligo­(p-phenylene vinylene) derivatives on
the water surface.

Structural Rearrangement of Organic
Semiconductor Molecules with an Asymmetric
Shape in Thin Films
2-Decyl-7-phenyl[1]benzothieno[3,2-b][1]benzothiophene(Ph-BTBT-C10) exhibits excellent performances as an active layer in organic thin-film transistors, and its performances
are greatly influenced by the molecular packing, i.e., thecrystalline polymorphs. This compound has the so-called
thin-film phase in a vapor-deposited film, which is different
from the single-crystal structure (the bulk phase). In thiswork, thin films of Ph-BTBT-C10 are prepared by spin
coating, and the effect of aging on the film structure isinvestigated by high-resolution IR spectroscopy in combination with X-ray diffraction. The results show that theas-spun film has the same thin-film phase as the vapordeposited film and that the thin-film phase is rapidly converted to the bulk phase by aging at room temperature. This

Conformational Change of Alkyl Chains at
Phase Transitions in Thin Films of an
Asymmetric Benzothienobenzothiophene
Derivative
Ph-BTBT-C10 has a highly ordered liquid crystalline
state, i.e., the smectic E (SmE) phase. Although the transition from the crystalline state to the SmE phase is believedto accompany melting of the alkyl chains, no spectroscopic
evidence has been found so far. In this study, the conformational change of the decyl chains in Ph-BTBT-C10 films
across the phase transition is analyzed by temperaturedependent measurements in situ using IR spectroscopy.
The spectral analysis reveals that the polycrystalline film
has latent conformational disorder (the gauche conformer),the rate of which becomes more pronounced with theheat treatment. As expected, melting of the decyl chains isobserved above the transition temperature to the SmE
phase.

Figure 3. Conformational change of alkyl chains of Ph-BTBT-C10 withtemperature.

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Division of Environmental Chemistry– Molecular Microbial Science –https://www.scl.kyoto-u.ac.jp/~mmsicr/mmstojp/Top_en.html

Prof
KURIHARA, Tatsuo(D Eng)

Assoc ProfKAWAMOTO, Jun(D Agr)Assist Prof
OGAWA, Takuya(D Agr)Assist Res Staff

Researcher (pt)

KITAYAMA, Kaori

SUWANAWAT, Nittikarn

Students
ZHU, Mengshan (D3)
TSUDZUKI, Taiku (D2)INOUE, Hiromu (M2)
YOUN, Jae Hyung (M2)

YANG, Yuanzheng (M2)
SAKAMOTO, Daiki (M1)

SHIODA, Yudai (M1)YOSHIDA, Riki (M1)

Scope of Research
Microorganisms are found almost everywhere on Earth. They
have a great diversity of capacities to adapt to various environments, including chemically and physically unusual environments.
Our main subject is to clarify the molecular basis of environmental adaptations of microorganisms and their application.
Specific functions of proteins and lipids with essential roles inenvironmental adaptation of extremophilic microorganisms areof our particular interest. We also undertake mechanistic analysisof microbial enzymes, in particular, those involved in uniquemetabolic pathways, and their appli­cation.

KEYWORDS
Extremophiles
Phospholipid Acyltransferase

Bacterial Cold-Adaptaion Mechanism
Extracellular Membrane Vesicle

Polyunsaturated Fatty Acid

Recent Selected Publications
Kawano, K.; Kamasaka, K.; Yokoyama, F.; Kawamoto, J.; Ogawa, T.; Kurihara, T.; Matsuzaki K., Structural Factors Governing Binding of
Curvature-Sensing Peptides to Bacterial Extracellular Vesicles Covered with Hydrophilic Polysaccharide Chains, Biophys. Chem., 299,
107039 (2023).
Kamasaka, K.; Kawamoto, J.; Tsudzuki, T.; Liu, Y.; Imai, T.; Ogawa, T.; Kurihara, T., Capsular Polysaccharide-Mediated Protein Loading onto
Extracellular Membrane Vesicles of a Fish Intestinal Bacterium, Shewanella vesiculosa HM13, bioRxiv, 04.25.538355 (2023).
Mullane, K. K.; Nishiyama, M.; Kurihara, T.; Bartlett, D. H., Compounding Deep Sea Physical Impacts on Marine Microbial Motility, Front.
Mar. Sci., 10 (2023).
Ogawa, T.; Kuboshima, M.; Suwanawat, N.; Kawamoto, J.; Kurihara, T., Division of the Role and Physiological Impact of Multiple
Lysophosphatidic Acid Acyltransferase Paralogs, BMC Microbiol., 1, 241 (2022).

34

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Conversion of Docosahexaenoic Acid toEicosapentaenoic Acid by β-Oxidation
Enzymes in Shewanella livingstonensis Ac10

Screening and Identification of Genes
Involved in Extracellular Membrane Vesicle
Production of Shewanella vesiculosa HM13

Shewanella livingstonensis Ac10, a cold-adapted Gramnegative bacterium isolated from Antarctic seawater,
produces eicosapentaenoic acid (EPA) at low temperatures.
An EPA-less mutant strain (ΔEPA) showed delayed
growth and cold-sensitive phenotypes. ΔEPA cultured in
the medium supplemented with docosahexaenoic acid
(DHA)-containing phospholipids grew normally at low
temperatures. Interestingly, the mutant contained not only
DHA-containing phospholipids but also EPA-containing
phospholipids even though it cannot produce EPA de novo.
These results suggested S. livingstonensis Ac10 requires
EPA or DHA to adapt to low temperatures, and it has an
unknown conversion pathway of DHA to EPA to generate
EPA selectively. Previous studies demonstrated that firsttwo β-oxidation enzymes, acyl-CoA dehydrogenase (FadE)
and 2,4-dienoyl-CoA reductase (FadH), are involved inthis conversion of DHA to EPA. Therefore, the conversion
pathway is likely identical or similar to the β-oxidation
pathway. On the other hand, it is unclear how EPA is produced from DHA by β-oxidation, in which a series ofoxidation reactions repeatedly occur to degrade fatty acids
into acetyl-CoA in general, and whether the last two βoxidation enzymes, FadB and FadA, or FadJ and FadI, areinvolved in this conversion. Gene-deletion analysis ofthese genes demonstrated that, in the single fad mutant
strains, EPA converted from DHA was accumulated, andEPA-containing phospholipids were produced. ΔEPA/
ΔFadJ had DHA more than the others, and unknown fatty
acids predicted as intermediates were observed in the mutant.
However, every fad mutant, including ΔEPA/ΔFadJ, still
has the conversion ability, indicating the redundant role of
FadB/FadJ and FadA/FadI in the conversion. Therefore,
double knockout strains, ΔEPA/ΔFadBJ and ΔEPA/
ΔFadAI, were constructed. In ΔEPA/ΔFadBJ strain, the
DHA-to-EPA conversion rate was decreased by 32%
compared with ΔEPA. These results revealed the ßoxidation enzymes play a role in the DHA-EPA conversionof this bacterium.

Extracellular membrane vesicles (EMVs) are lipid
nanoparticles secreted by almost all bacteria, and their
physiology and biotechnological applications have been
attracting significant attention. However, the molecularbasis of EMV biogenesis has yet to be fully elucidated. To
facilitate the elucidation of bacterial EMV production, acurvature-sensing peptide, nFAAV5-NBD, was developedby using a hyper-vesiculating bacterium, Shewanella
vesiculosa HM13, as a model organism. nFAAV5-NBD
can bind to EMVs of this bacterium but not to the cells. In
this study, we applied nFAAV5-NBD to screen a hypervesiculation and hypo-vesiculation mutant from the mutant
library generated by transposon random mutagenesis (Fig. 2).
As a result, we identified 16 or six genes whose transposon
insertions caused hyper- or hypo-vesiculation, respectively.
Identification of the transposon-insertion site indicated thatgenes involved in various cell processes, including protein
quality control, cell wall synthesis, and signal transduction,
are involved in the EMV production of S. vesiculosa
HM13. A target gene disruption analysis of the identified
genes also demonstrated the changes in EMV productionof the mutants. These strains obtained in this study would
contribute to the elucidation of bacterial vesicle formation
mechanisms. Additionally, the hyper-vesiculating mutants
obtained from this study would provide a clue for the application of this bacterium, for example, the production ofvaluable substances as a cargo of EMVs and the development of surface-engineered vesicles.

Figure 1. Putative conversion pathway of DHA to EPA.

Figure 2. Schematic illustration of the high-throughput screening of themutants with changes in EMV production of S. vesiculosa HM13.

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Division of Multidisciplinary Chemistry– Polymer Materials Science –https://www.scl.kyoto-u.ac.jp/~polymat/index.html

Prof
TAKENAKA, Mikihito(D Eng)

Assoc Prof
OGAWA, Hiroki(D Eng)Assist Prof
NAKANISHI, Yohei(D Eng)Assist Techn Staff
ISODA, KumikoStudents
SEKO, Tamio (D2)
HAMAMOTO, Hiroki (D2)ARAKAWA, Masato (D1)
TAMURA, Yukiko (D1)

KARITANI, Shu (M2)BANDO, Shunsuke (M2)
MORIMOTO, Ryuji (M2)
NOMURA, Yuki (M2)

SHIRAISHI, Harunori (M1)
HOSOMI, Yu (M1)
SHIMABUKURO, Wataru (M1)
KUBO, Haruki (UG)

TOBITA, Naoto (UG)
YOSHINO, Syunki (UG)

Scope of Research
The structure and molecular motion of polymer substances are studied, mainly using scattering methods such as X-ray,
neutron, and light with intent to solve fundamentally important problems in polymer science. The main projects are­studied on 1) the morphologies and the dynamics of self-assembling processes in block copolymers, 2) the hierarchicalstructures in crystalline polymer and rubber-filler systems, 3) the viscoelastic effects in glassy materials, 4) formation
processes and ordering structures in polymer thin films.

KEYWORDS
Polymer Physics
Self Assembly
Hierarchical Structure

Polymer Properties
Softmatter

Recent Selected Publications
Nakanishi, Y.; Ishige, R.; Ogawa, H.; Huang, Y.; Sakakibara, K.; Ohno, K.; Kanaya, T.; Takenaka, M.; Tsujii, Y., Unified Explanation for
Self-Assembly of Polymer-Brush-Modified Nanoparticles in Ionic Liquids, Polym. J., 55, 1199-1209 (2023).
Shibata, M.; Nakanishi, Y.; Abe, J.; Arima-Osonoi, H.; Iwase, H.; Shibayama, M.; Motokawa, R.; Kumada, T.; Takata, S.; Yamamoto, K.;
Takenaka, M.; Miyazaki, T., Structural Changes of Polystyrene Particles in Subcritical and Supercritical Water Revealed by in situ Small-Angle
Neutron Scattering, Polym. J., 55, 1165-1170 (2023).
Watanabe, Y.; Ogawa, H.; Konishi, T.; Nishitsuji, S.; Ono, S.; Shimizu, N.; Takenaka, M., Distribution of Oriented Lamellar Structures in InjectionMolded High-Density Polyethylene Visualized via the Small Angle X-ray Scattering-Computed Tomography Method, Macromolecules,
56(15), 5964-5973 (2023).
Watanabe, Y.; Nishitsuji, S.; Takenaka, M., Anomalous Small-Angle X-ray Scattering Analyses on Hierarchical Structures of Rubber–Filler
Systems, J. Appl. Crystallogr., 56 (2), 461-467 (2023).
Kishimoto, M.; Takenaka, M.; Iwabuki, H., Spatial Distribution of the Amorphous Region Constrained by Polymer Crystallites, Macromolecules,
56 (1), 207-214 (2023).

36

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Anomalous Small-Angle X-Ray Scattering
Analyses on Hierarchical Structures of
Rubber–Filler Systems

Distribution of Oriented Lamellar Structuresin Injection-Molded High-Density Polyethylene
Visualized via SAXS-CT Method

The hierarchical structures of carbon black (CB) in
Poly(styrene-ran-butadiene) (SBR) rubber/CB systems
vulcanized with sulfur and ZnO were clarified by using
anomalous small-angle X-ray scattering (ASAXS) near
the Zn absorption edge. The SBR/CB systems vulcanizedwith sulfur and ZnO are commonly used and quantitative
analyses of the hierarchical structures in the SBR/CB
systems are needed. However, the hierarchical structures in
the SBR/CB systems have not been well investigated since
the strong scattering contrast of Zn hinders the quantitative
analyses of the hierarchical structures of CB by using
X-ray scattering. In this study, we eliminated the effects of
Zn on the scattering intensity and obtained the structure
factors of CB in SBR/CB systems by using the ASAXS
method. By extrapolating the structure factors of CB to azero-volume fraction of CB, we were able to estimate theparticle structure factor of the CB aggregate and foundthat the CB aggregates consist of the closely-packed CB
primary particles. We also found the existence of the large
particles of ZnO and the particles of ZnS in the order of 10
nm in the structure factors of Zn.

We successfully reconstructed the spatial distribution of
the orientation of the lamellar structures in injectionmolded high-density polyethylene (HDPE) using thesmall-angle X-ray scattering-computed tomography(SAXS-CT) technique, a combination of the SAXS and CT
methods. The skin, subskin, and core layers were identified
in the obtained images of the distribution. The orientationand thickness in each layer were found to vary with theinjection speed, v. At the slowest v of 5 mm/s, a skin layer
is formed along the surface of the sample with the lamellar
structure oriented in the injection direction. At the centerof the sample, the orientation of the lamellar structure isisotropic, i.e., the core layer. Between the skin and corelayers, there is the subskin layer where the lamellar structures are oriented perpendicular and parallel to the injection
direction. The thickness of the core layer decreases for 5 ≤v ≤ 20 mm/s because the higher elongation of the polymer
chains due to the shear deformation is dominant. For 20 ≤v ≤ 40 mm/s, the strength of the fountain flow and the shear
deformation affect the thickness of the layers. The core layer
corresponds to the outlet portion of the fountain flow. The
increase in the fountain flow amount inhibits the higher
orientation of polymer chains, resulting in an almost
constant thickness of the core layer with v. In the subskinlayer, the increase in the higher elongation of polymer
chains with v induces an increase in the thickness for 5 ≤ v≤ 20 mm/s. Although the velocity gradient is even moresignificant, the suppression of the polymer chain orientationby the fountain flow can result in a nearly constant subskinlayer thickness for 20 ≤ v ≤ 40 mm/s. The flux of polymers
originating from the fountain flow oriented perpendicular
to the injection direction is dominant. Unlike the exponential changes in the core and subskin layers, the thickness of the skin layer decreases in proportion to the increasein v potentially because the fountain flow effect increases
for 5 ≤ v ≤ 40 mm/s, suppressing the shear deformationnear the mold.

Figure 1. Schematic for hierarchical structures of filler in rubber. Partial
scattering function PCC(q)/ϕCB of CB for all samples.

Figure 2. SAXS-CT images in the X-Y plane reconstructed from the
SAXS profiles at each φ1 and Y. Each injection speed condition is v = 5mm/s for (a), 20 mm/s for (b), and 40 mm/s for (c). The injection direction
is toward the front of the paper.

ICR ANNUAL REPORT, 2023

37

Division of Multidisciplinary Chemistry– Molecular Rheology –https://molrheo.kuicr.kyoto-u.ac.jp/en/

Assoc Prof
MATSUMIYA, Yumi
(D Eng)Assist Prof
SATO, Takeshi(D Eng)Students
MATSUTO, Naoki (M2)TOSAKI, Tomohiro (M2)

YAMAMOTO, Ayumu (M1)
KITAGAWA, Yoshifumi (UG)

Guest Scholars
KWON, Youngdon (Ph D)
LIM, KyungKon (Ph D)

Sungkyunkwan University, Korea, 15 January 2023–20 January 2023
Ewha Womens University, Korea, 15 January 2023–18 January 2023

Scope of Research
Research focus is placed on the molecular origin of­rheological properties of various materials. Depending ontime and temperature, homogeneous polymeric materials
exhibit typical features of glass, rubber, and viscous fluid
while ­heterogeneous polymeric systems exhibit plasticity
in addition to these features. For basic understanding ofthese features, the molecular motion and structures at various scales are studied for polymeric systems in deformed
state. Rheological measurements are performed with various rheometers. Auto-correlation of the molecular orientation is also investigated with dynamic dielectric spectroscopy. Analysis of rheological and dielectric behavior
elucidates a new aspect of softmatter physics.

KEYWORDS
Rheology
Soft Matter

Dielectric Spectroscopy
Mesoscopic Model

Recent Selected Publications
Sato, T.; Gong, Y.; Larson, R. G., Testing the Ability of the Slip-Spring Model to Describe Constraint Release Effects Using Experimental
Linear and Nonlinear Rheology, Macromolecules, 56, 8116-8132 (2023).
Miyamoto, S.; Sato, T.; Taniguchi, T., Stretch-Orientation-Induced Reduction of Friction in Well-Entangled Bidisperse Blends: a Dual SlipLink Simulation Study, Rheologica Acta, 62, 57-70 (2023).
Matsumiya, Y.; Sato, T.; Chen, Q.; Watanabe, H., Rouse Analysis of Nonlinear Rheology of Unentangled Polymer Melts under Fast Shear:
Viscoelastic Response to Superposed Oscillatory Strain, Macromolecules, 56, 2930-2983 (2023).

38

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Rouse Analysis of Nonlinear Rheology ofUnentangled Polymer Melts under Fast
Shear: Viscoelastic Response to Superposed
Oscillatory Strain

sition, respectively. In the case of negligible off-diagonalcomponents of ζ and B, the Rouse analysis gave a very[G][G]
simple expression of those moduli, G* (ω) = b G * (ωα )
X

X

eq

X

* (ω) is the linear viscoelastic
with X = ∥ and ⊥, where Geq

Nonlinear rheological behavior of unentangled polymer
melts can be described by the Rouse model given that its(LVE) complex modulus at an angular frequency ω. Namely, in that case, the relaxation time of G* decreases by aparameters, spring strength κ, bead friction coefficient ζ,factor of αX (<1) and its terminal relaxation intensity isand mean-square Brownian force intensity B, are allowedenhanced by a factor of bX (>1), but a relative distribution

to change under fast flow/large strain (and to take anisotro-of the relaxation modes exhibits no change. Furthermore,

pic tensorial forms when necessary). Within this model,

the Rouse parameters obtained from the η, Ψ1, and ε* data

analytic expressions in terms of those parameters haveof PBO-16k were found to satisfy a specific empirical rela[G] 2[G]ʹ (ω) ≅ Geq
ʹʹ (ω) ∝ ω1/2
tionship, {b∥ } ≅ 1/α∥ . Because Geq

been obtained for measurable quantities that include viscosity η, the first normal stress difference coefficient Ψ1,
and complex dielectric permittivity ε*. Those expressions

X

[G]

[G]

at high ω where the LVE Rouse relaxation has not complet[G]ʹʹ (ω) = Geqʹʹ (ω) at ω > 1/τ∥
ed, this relationship suggests G∥

data of unentangled melts. In particular, the rheo-dielectric[G][G]
ʹʹ (ω) < Geqʹʹ (ω) at ω < 1/τ∥, where τ∥ is the terminal
and G∥
viscoelastic relaxation time defined for G * (ω). This be-ε* data under shear, recently obtained for unentangledʹʹ (ω) is superficially equivalent to that expecthavior of G∥

low-M poly (butylene oxide) melt having type-A dipoles

ed for a case of disappearance of viscous contributions of(PBO-16k; M = 16 × 10 ), suggest that the tensorial ζ andlow-order Rouse eigenmodes under fast shear discussed in

B have negligibly small off-diagonal components in a

the literature on the basis of the concept of Pincus blob.

range of Weissenberg number Wi up to 1.2. On the basis ofthat study, we here focus on the complex shear moduli G *However, the current Rouse analysis clearly indicated thatin turn enable us to extract κ, ζ, and B from experimental

3∥

and G * of the Rouse chain defined as responses to a small⊥∥

all eigenmodes keep their viscous contributions with amagnitude determined by ζ and κ under flow, confirming

oscillatory strain superposed on the steady shear flow, with

the importance of nonequilibrium changes of ζ and κ in the∥ and ⊥ representing parallel and perpendicular superpo-

nonlinear flow behavior of unentangled melts.

ICR ANNUAL REPORT, 2023

39

Division of Multidisciplinary Chemistry– Molecular Aggregates –https://www.scl.kyoto-u.ac.jp/~wakamiya/english/index.html

Prof
WAKAMIYA, Atsushi(D Eng)Senior Lect
Assist Prof
Assist Prof *MURDEY, Richard NAKAMURA, Tomoya TRUONG, Minh Anh(Ph D)(D Eng)(D Eng)PD
OHASHI, Noboru(D Eng)*New Research Field
Development ProjectStudents
PD
CHEN, Chien-Yu(Ph D)PD
TSUJI, Ryuki(D Eng)

HASHIMOTO, Ruito (D3)
TAN, Tiancheng (D2)
HASEGAWA, Akio (D1)MIYAKE, Yuki (M2)
HARATA, Fuyuki (M2)

Researchers (pt)
SHIMAZAKI, Ai

HIRA, Shota (M2)
ADACHI, Yuta (M1)
SAKAMOTO, Chihiro (M1)
WAN, Linbo (M1)

Assist Techn Staff

IWASAKI, Yasuko

MATSUSHIGE, Yuko

HARAMATSU, Megumi

OGAWA, Hiroyuki

Scope of Research
We design and synthesize unique electronic materials withsophisticated device applications in mind. These materials havenovel solid-state aggregation structures or well-defined interface
orientation that promote efficient electrical current flow or enhancedevice lifetime. Electronic devices based on these new materials arethen evaluated ­using advanced measurement techniques, and theresults are used to inform the next direction of the materials chemistry. We call this synergistic approach for achieving our researchgoals “Needs ­Inspired Fundamental Science”.

KEYWORDS
Molecular Design and Synthesis

Molecular Aggregation

Functional Materials

Semiconductors

Perovskite Solar Cells

Recent Selected Publications
Hu, S.; Zhao, P.; Nakano, K.; Oliver, R. D. J.; Pascual, J.; Smith, J. A.; Yamada, T.; Truong, M. A.; Murdey, R.; Shioya, N.; Hasegawa, T.;
Ehara, M.; Johnston, M. B.; Tajima, K.; Kanemitsu, Y.; Snaith, H. J.; Wakamiya, A., Synergistic Surface Modification of Tin-Lead Perovskite
Solar Cells, Adv. Mater., 35, 2208320 (2023).
Truong, M. A.; Funasaki, T.; Ueberricke, L.; Nojo, W.; Murdey, R.; Yamada, T.; Hu, S.; Akatsuka, A.; Sekiguchi, N.; Hira, S.; Xie, L.; Nakamura,T.; Shioya, N.; Kan, D.; Tsuji, Y.; Iikubo, S.; Yoshida, H.; Shimakawa, Y.; Hasegawa, T.; Kanemitsu, Y.; Suzuki, T.; Wakamiya, A., Tripodal
Triazatruxene Derivative as a Face-On Oriented Hole-Collecting Monolayer for Efficient and Stable Inverted Perovskite Solar Cells, J. Am.
Chem. Soc., 145, 7528-7539 (2023).
Tan, T.; Nakamura, T.; Murdey, R.; Hu, S.; Truong, M. A.; Wakamiya, A., BAr2-Bridged Azafulvene Dimers with Tunable Energy Levels for
Photostable Near-Infrared Dyes, Chem. Eur. J., 29, e202300529 (2023).
Hashimoto, R.; Nakamura, T.; Truong, M. A.; Murdey, R.; Wakamiya, A., Effects of Electron-Accepting Substituents on the Fluorescence of
Oxygen-Bridged Triarylamine, Dyes Pigm., 215, 111281 (2023).
Ohashi, N.; Kaneko, R.; Sakai, C.; Wasai, Y.; Higuchi, S.; Yazawa, K.; Tahara, H.; Handa, T.; Nakamura, T.; Murdey, R.; Kanemitsu, Y.; Wakamiya,A., Bilayer Indium Tin Oxide Electrodes for Deformation-Free Ultrathin Flexible Perovskite Solar Cells, Sol. RRL, 7, 2300221 (2023).
Liu, W.; Hu, S.; Pascual, J.; Nakano, K.; Murdey, R.; Tajima, K.; Wakamiya, A., Tin Halide Perovskite Solar Cells with Open-Circuit Voltages
Approaching the Shockley-Queisser Limit, ACS Appl. Mater. Interfaces, 15, 32487-32495 (2023).

40

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Synergistic Surface Modification of Tin–Lead
Perovskite Solar Cells
Interfaces in thin-film photovoltaics play a pivotal role in determining device efficiency and longevity. In this work, the top
surface treatment of mixed tin–lead (≈1.26 eV) halide perovskite
films for p–i–n solar cells is studied. Charge extraction is promoted by treating the perovskite surface with piperazine. This compound reacts with the organic cations at the perovskite surface,modifying the surface structure and tuning the interfacial energy
level alignment. In addition, the combined treatment with C60
pyrrolidine tris-acid (CPTA) reduces hysteresis and leads to efficiencies up to 22.7%, with open-circuit voltage values reaching
0.90 V, ≈92% of the radiative limit for the bandgap of this material. The modified cells also show superior stability, with unencapsulated cells retaining 96% of their initial efficiency after>2000 h of storage in N2 and encapsulated cells retaining 90%
efficiency after >450 h of storage in air. Intriguingly, CPTA preferentially binds to Sn2+ sites at film surface over Pb2+ due to theenergetically favored exposure of the former, according tofirst-principles calculations. This work provides new insights into
the surface chemistry of perovskite films in terms of their structural, electronic, and defect characteristics and this knowledge isused to fabricate state-of-the-art solar cells.1)

Figure 1. Surface modification of tin–lead perovskite films with piperazine and CPTA.

Figure 2. Triazatruxene-based tripodal hole collecting monolayer for inverted perovskite solar cells.

BAr2-Bridged Azafulvene Dimers with Tunable
Energy Levels for Photostable Near-Infrared
Dyes
Organic dyes with strong absorption in the near-infrared (NIR)
region are potentially useful in medical applications, such as tumor imaging and photothermal therapy. In this work, new NIR
dyes combining BAr2-bridged azafulvene dimer acceptors withdiarylaminothienyl donors in a donor–acceptor–donor configuration were synthesized. Surprisingly, it was found that in thesemolecules the BAr2-bridged azafulvene acceptor adopts a 5-membered, rather than 6-membered ring structure. The influence of thearyl substituents on the HOMO and LUMO energy levels of thedye compounds was assessed from electrochemical and opticalmeasurements. Strong electron-withdrawing fluorinated substituents (Ar = C6F5, 3,5-(CF3)2C6H3) lowered the HOMO energy
while preserving the small HOMO–LUMO energy gap, resulting
in promising NIR dye molecules that combine strong absorption
bands centered around 900 nm with good photostability.3)

Tripodal Triazatruxene Derivative as a
Face-On Oriented Hole-Collecting Monolayer
for Efficient and Stable Inverted Perovskite
Solar Cells
Hole-collecting monolayers have drawn attention in perovskite solar cell research due to their ease of processing,high performance, and good durability. Since molecules in
the hole-collecting monolayer are typically composed offunctionalized π-conjugated structures, hole extraction is
expected to be more efficient when the π-cores are oriented
face-on with respect to the adjacent surfaces. However,strategies for reliably controlling the molecular orientationin monolayers remain elusive. In this work, multiple phosphonic acid anchoring groups were used to control the molecular orientation of a series of triazatruxene derivatives
chemisorbed on a transparent conducting oxide electrodesurface. Using infrared reflection absorption spectroscopy
and metastable atom electron spectroscopy, we found thatmultipodal derivatives align face-on to the electrode surface, while the monopodal counterpart adopts a more tilted
configuration. The face-on orientation was found to facilitate hole extraction, leading to inverted perovskite solar
cells with enhanced stability and high-power conversion
efficiencies up to 23.0%.2)

Figure 3. BAr2-bridged azafulvene dimer for photostable near-infrareddyes.
References
1) S. Hu, P. Zhao, K. Nakano, R. D. J. Oliver, J. Pascual, J. A. Smith, T.
Yamada, M. A. Truong, R. Murdey, N. Shioya, T. Hasegawa, M. Ehara,
M. B. Johnston, K. Tajima, Y. Kanemitsu, H. J. Snaith, A. Wakamiya, Adv.
Mater., 35, 2208320 (2023).
2) M. A. Truong, T. Funasaki, L. Ueberricke, W. Nojo, R. Murdey, T.
Yamada, S. Hu, A. Akatsuka, N. Sekiguchi, S. Hira, L. Xie, T. Nakamura,
N. Shioya, D. Kan, Y. Tsuji, S. Iikubo, H. Yoshida, Y. Shimakawa, T.
Hasegawa, Y. Kanemitsu, T. Suzuki, A. Wakamiya, J. Am. Chem. Soc.,
145, 7528-7539 (2023).
3) T. Tan, T. Nakamura, R. Murdey, S. Hu, M. A. Truong, A. Wakamiya,
Chem. Eur. J., 29, e202300529 (2023).

ICR ANNUAL REPORT, 2023

41

Advanced Research Center for Beam Science– Particle Beam Science –https://pbs.kuicr.kyoto-u.ac.jp/en/

Prof
WAKASUGI, Masanori(D Sc)

Assoc ProfTSUKADA, Kyo(D Sc)

Assist Prof *OGAWARA, Ryo(D Med Sc)

Techn Staff
TONGU, Hiromu*New Research Field
Development ProjectStudents
YOSHIDA, Satoru (M2)

TACHIBANA, Mariko (M1)

MAEDA, Yusei (M1)

Scope of Research
One of our research is an experimental research for unstable nuclear structures by means of the electron and heavy-ion
accelerators. We address the technical development in an RI beam production driven by a high-energy electron beam, anelectron scattering from the RI’s in combination with the RI target inserted in an electron storage ring, and the precisionmass measurement for extremely short-lived and rare exotic nuclei using a heavy-ion storage ring. We will address sometechnical development aiming at a nuclear photo-absorption cross-section measurement and the beam recycling in aheavy-ion storage ring to study the nuclear reactions involving rare exotic nuclei.

KEYWORDS
Beam Physics
Unstable Nuclear Physics
Electron Linac

Accelerator Physics
Storage Ring

Recent Selected Publications
Tsukada, K.; Abe, Y.; Enokizono, A.; Goke, T.; Hara, M.; Honda, Y.; Hori, T.; Ichikawa, S.; Ito, Y.; Kurita, K.; Legris, C.; Maehara, Y.; Ohnishi,T.; Ogawara, R.; Suda, T.; Tamae, T.; Wakasugi, M.; Watanabe, M.; Wauke, H., First Observation of Electron Scattering from Online-Produced
Radioactive Target, Phys. Rev. Lett., 131, 092502 (2023).
Ogawara, R.; Abe, Y.; Ohnishi, T.; Enokizono, A.; Hara, M.; Hori, T.; Ichikawa, S.; Kurita, K.; Maehara, Y.; Suda, T.; Tsukada, K.; Wakasugi,
M.; Watanabe, M.; Wauke, H., Ion-Trapping Properties of SCRIT: Time Evolutions of 138Ba Charge State Distributions, Nucl. Instr. Met.,
B541, 90-92 (2023).
Miyata, K.; Ogawara, R.; Ishikawa, M., Improvement of Crystal Identification Accuracy for Depth-of-Interaction Detector System with Peakto-Charge Discrimination Method, Sensors, 23, 4584 (2023).
Li, H. F.; Naimi, S.; Sprouse, T. M.; Mumpower, M. R.; Abe, Y.; Yamaguchi, Y.; Nagae, D.; Suzaki, F.; Wakasugi, M.; Arakawa, H.; Dou, W.
B.; Hamakawa, D.; Hosoi, S.; Inada, Y.; Kajiki, D.; Kobayashi, T.; Sakaue, M.; Yokoda, Y.; Yamaguchi, T.; Kagesawa, R.; Kamioka, D.; Moriguchi,T.; Mukai, M.; Ozawa, A.; Ota, S.; Kitamura, N.; Masuoka, S.; Michimasa, S.; Baba, H.; Fukuda, N.; Shimizu, Y.; Suzuki, H.; Takeda, H.; Ahn,
D. S.; Wang, M.; Fu, C. Y.; Wang, Q.; Suzuki, S.; Ge, Z.; Litvinov, Yu. A.; Lorusso, G.; Walker, P. M.; Podolyak, Zs.; Uesaka, T., First
Application of Mass Measurements with the Rare-RI Ring Reveals the Solar r-Process Abundance Trend at A = 122 and A = 123, Phys. Rev.
Lett., 128, 152701 (2022).
Kusumoto, T.; Inoue, S.; Ogawara, R.; Kodaira, S., Measurement of the Energy Spectrum of Laser-Accelerated Protons Using FNTD:
Development of an Easy and Quick Method for Energy Spectrometry, Radiat. Meas., 151, 106715 (2022).

42

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Electron Scattering for Determining Charge
Density Distribution of Unstable Nuclei
As demonstrated in the 1950s by Hofstadter and his colleagues, high-energy electron scattering is one of the mostpowerful and reliable methods to reveal the internal structure of atomic nuclei. This is because of the following features: 1) an electron is an elementary particle and has nointernal structure, 2) the electro-magnetic interaction iswell understood and there is almost no ambiguity in theoretical calculations, and 3) electrons can probe deep inside
the nucleus without causing any serious disturbance. In thelatter half of the 20th century, many nuclei were investigated by electron scattering, and numerous basic and important features of nuclei, especially stable nuclei, were established.
After progresses of accelerator technique and detector
developments, it became possible to artificially create unstable nuclei (RI) and extract them as RI beams. Recently,
research on short-lived RIs has become very active all over
the world following discoveries of exotic phenomena, suchas neutron halo/skin, new magic numbers and disappearance of the magic numbers. Although electron scattering
should be useful even for internal structure of such Ris, it
has never been applied to short-lived Ris due to difficulty
for preparing target with thickness enough to perform electron scattering experiment.
To overcome this challenge, we have developed agroundbreaking technique known as SCRIT (Self-Confining Radioactive Isotope Ion Target). This innovative method leverages the ion trapping of residual gases in an electron ring, a phenomenon typically responsible for electron
beam instability but ingeniously utilized in this context.

Following successful commissioning, construction of
the SCRIT electron scattering facility (see Fig. 1) began at
the RI Beam Factory at RIKEN in 2009 and was completed
in recent years.

Figure 1. Overview of SCRIT electron scattering facility.

Our research has specifically focused on electron scattering experiments targeting atomic nuclei around a neutron magic number of N = 82. Notably, an experiment involving 137Cs, generated by the photofission reaction of
uranium, represents the world’s first electron scatteringexperiment with online produced RI and was published in
the Physical Review Letters journal this year. Fig. 2 shows
obtained momentum and angular distributions. This
achievement has garnered significant attention, including afeatured article in Physics Today.

Figure 2. (a) Reconstructed momentum distribution of scattered electrons, (b) Obtained angular distribution of 137Cs (pink) and background(blue) and theoretical calculations (solid lines).

ICR ANNUAL REPORT, 2023

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Advanced Research Center for Beam Science– Laser Matter Interaction Science –https://en.laser.kuicr.kyoto-u.ac.jp/

Prof
TOKITA, Shigeki(D Eng)Assist ProfOKAZAKI, Daiki(D Eng)

Program-Specific Assoc ProfKANAI, Tsuneto(D Sc)Res (pt)
HASHIDA, Masaki(D Eng)Researcher (pt)MURAKAMI, Masanao (D Sc)

Scope of Research
We are developing cutting-edge high-intensity laser sources and studying experimental research on the laser interaction
with matter by using the new laser sources. We are promoting cross-disciplinary research based on high-intensity laser
technologies such as development of high-intensity mid-infrared solid-state lasers and fiber lasers, research on particle
acceleration and wavelength conversion with plasmas produced by high-intensity ultrafast lasers, development of laser
isotope separation method for neutrino research, and search for dark matter using high-intensity lasers.

KEYWORDSHigh Power Laser Optics
Ultrafast Laser Physics
Laser-Plasma Interaction Physics
Laser Isotope Separation
Laser Nano-Ablation Physics

Recent Selected Publications
Goya, K.; Sasanuma, H.; Ishida, G.; Uehara, H.; Tokita, S., Fusion Splicing of Plastic Optical Fibers Using a Mid-IR Fiber Laser, Appl. Phys.
Express, 16, 052006 (2023).
Homma, K.; Tesileanu, O.; Nakamiya, Y.; Kirita, Y.; Chiochiu, C.; Cuciuc, M.; Giubega, G.; Hasada, T.; Hashida, M.; Ishibashi, F.; Kanai, T.;
Kodama, A.; Masuno, S.; Miyamaru, T.; Neagu, L.; Rodrigues, V. R. M.; Rosu, M. M.; Sakabe, S.; Tamlyn, J.; Tazlauanu, S. V.; Tokita, S.,
Challenge of Search for Cosmological Dark Components with High-Intensity Lasers and beyond, Eur. Phys. J. A., 59, 109 (2023).
Fujiwara, M.; Inoue, S.; Masuno, S.; Fu, H.; Tokita, S.; Hashida, M.; Mizuochi, N., Creation of NV Centers over a Millimeter-Sized Region by
Intense Single-Shot Ultrashort Laser Irradiation, APL Photonics, 8, 036108 (2023).
Ishibashi, F.; Hasada, T.; Homma, K.; Kirita, Y.; Kanai, T.; Masuno, S.; Tokita, S.; Hashida, M., Pilot Search for Axion-Like Particles by aThree-Beam Stimulated Resonant Photon Collider with Short Pulse Lasers, Universe, 9, 123 (2023).
Li, E.; Uehara, H.; Tokita, S.; Yao, W.; Yasuhara, R., A Hybrid Quantum Cascade Laser/Fe:ZnSe Amplifier System for Power Scaling of CW
Lasers at 4.0–4.6 µm, Optics & Laser Technology, 157, 108783 (2023).

44

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
High-Intensity Mid-Infrared Fe:ZnSe Lasers
The mid-infrared (mid-IR) spectral region has long garneredsignificant interest for its spectroscopic applications. Thermal
lamp-based mid-IR light sources have been traditionally employed for trace gas sensing, which is crucial for environmental
monitoring, medical diagnostics, and other uses. However, therecent advancements in mid-IR broadband ultrafast lasers have
paved the way for pioneering applications. These applications
range from generating attosecond pulses, coherent X-ray
radiation, creating high-density plasmas, and even contributing to the investigation of dark matter, in addition to theirestablished use in molecular vibrational spectroscopy.
To achieve the desired high intensity in mid-IR lasers, opticalparametric amplification (OPA) based laser systems havebeen the subject of extensive research in recent years. Thesesystems necessitate the use of an ultra-high intensity nearinfrared pump laser source. They also require complex
femtosecond-scale timing synchronization mechanisms. Suchrequirements often lead to laser systems that are inherently
unstable and not user-friendly, posing significant challenges
for both developers and end-users alike.
In our project, we have focused on iron-doped zinc selenide(Fe:ZnSe, as depicted in Fig. 1) as a promising laser gain
medium. Fe:ZnSe exhibits a broad emission spectrum centeredaround the 4-micron wavelength and is capable of supporting
ultrafast laser operations with a temporal duration of 100
femtoseconds. Additionally, it possesses an absorption band at
the 3-micron wavelength, aligning perfectly with our homemade, world-class high-power continuous wave laser systems,
such as erbium-doped ZBLAN fiber lasers and Er:YAP solidstate lasers (in collaboration with Prof. Yasuhara’s group at
NIFS). The Fe2+ ions’ 3d electronic energy levels in ZnSe
facilitate an upper state lifetime of approximately 100 microseconds, which obviates the need for an ultra-high intensity
near-infrared pump laser source and sophisticated timing synchronization systems.
Figure 2 shows our mid-infrared laser system, which integrates a home-built seeding apparatus — comprising a Yb:CaF2
regenerative amplifier and a three-stage KTA OPA — with an
Fe:ZnSe amplifier. The entire system, which is compactly
assembled on just two optical tables, would offer a robust anduser-friendly platform for cutting-edge mid-IR laser research
and applications.

Figure 1. The picture of Fe:ZnSe laser crystal.

Figure 2. The picture of our mid-infrared laser system.

Blue-Violet High-Power Diode Laser System
for 48Ca Isotope Separation
In an effort to confirm the Majorana nature of neutrinos,
experiments worldwide are conducting double beta decay
studies without neutrino emission (0νββ decay). Given that0νββ decay is exceptionally rare (with an experimental lower
limit half-life of approximately 1026 years), it’s crucial to havea substantial quantity of target nuclei in an ultra-low background setting. Among the various nuclei capable of undergoing double beta decay, 48Ca stands out due to its highest Qvalue (4.27 MeV), surpassing natural radioactive activities,
thereby promising minimal background interference. The
CANDLES experiment achieved a background level ofroughly 10−3 events/keV/yr/(kg of natCa), using about 305 kgof natCaF2 scintillator (containing ~7.3 mol of 48Ca) as theprimary detector [Phys. Rev. D, 103, 092008 (2021)]. To
enhance the experiment’s sensitivity, isotope enrichment isimperative due to 48Ca’s low natural abundance (0.187%),
along with ongoing efforts to further reduce background noise.
Traditional enrichment methods like centrifugation and gas
diffusion are unfeasible for 48Ca, as it lacks a gaseous compound at room temperature, prompting the development ofalternative chemical and physical techniques.
Our team is exploring a laser isotope separation (LIS)
method for 48Ca enrichment. The transition of calcium fromits ground state occurs at a wavelength of approximately 422.7
nm, which can be excited using commercially available
blue-violet laser diodes (LDs). The linewidth of these external
cavity LDs is sufficiently narrow relative to the isotope shift inthis transition, which is about several hundred MHz. However,generating around 1000 kg of 48Ca for the experiment demands
a high-power laser system exceeding kilowatts.
The gallium nitride (GaN) LD is emerging as the mostpromising laser source for this application due to its efficiency, compactness, longevity, reliability, and cost-effectiveness.
Yet, developing a cost-effective technology that combineshigh power with single frequency in LDs is a challenge. For
example, achieving a total optical power of 1 kW could require
between 100 and 10,000 LD emitters. It’s crucial that the
wavelength of all emitters is precisely stabilized to match theabsorption line of the 48Ca isotope, with absolute accuracy
within a few MHz to counteract the ~60 MHz Doppler broadening of the Ca atomic beam. We are currently devising amethod to stabilize the wavelengths of multiple GaN-LDs
simultaneously. This technique will enable the scaling of laser
power by increasing the number of LDs while preserving thelaser wavelength and spectral linewidth, paving the way forpractical LIS applications and future isotope enrichment.

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Advanced Research Center for Beam Science– Electron Microscopy and Crystal Chemistry –http://eels.kuicr.kyoto-u.ac.jp/EMCC/home-en.html

Assoc ProfHARUTA, Mitsutaka(D Sc)

Assist Prof
Program-Specific Res*NEMOTO, Takashi KIYOMURA, Tsutomu(D Sc)*Nanotechnology Platform

Researcher (pt)Assist Techn Staff

Students

OGAWA, Tetsuya (D Sc)

SUZUKI, Hiroshi

LIN, I-Ching (D3)
SATO, Shinya (M2)
MORIMOTO, Syunji (M2)

YASUI, Kentaro (M2)
JO, Yoshiyuki (M1)

Scope of Research
In the field of nanotechnology, the importance of high spatial resolution analysis of materials
further increases. We study the structure and the electronic state of materials at atomic scale
through direct imaging of atoms or molecules by (scanning) transmission electron microscopy((S)TEM) combined with energy dispersive X-ray spectroscopy (EDS) and electron energy-loss
spectroscopy (EELS), which gives the information of elemental and electronic state. And we are
studying with the aim of establishing new analytical methods using electron microscopes andevaluating materials using these methods.

KEYWORDS
STEM
EELS
HAADF
Elemental Mapping
Channeling

Recent Selected Publications
Lin, I-C.; Haruta, M.; Nemoto, T.; Goto, M.; Shimakawa, Y.; Kurata, H., Extraction of Anisotropic Thermal Vibration Factors for Oxygen fromthe Ti L2,3-Edge in SrTiO3, J. Phys. Chem. C., 127(36), 17802-17808 (2023). Supplemental cover
Iwashimizu, C.; Haruta, M.; Nemoto, T.; Kurata, H., Different Atomic Contrasts in HAADF Images and EELS Maps of Rutile TiO2, Microscopy,
72(4), 353-360, (2023). Editor’s Choice
Haruta, M.; Kikkawa, J.; Kimoto, K.; Kurata, H., Comparison of Detection Limits of Direct-Counting CMOS and CCD Cameras in EELS
Experiments, Ultramicroscopy, 240, [113577-1]-[113577-6] (2022).
Haruta, M.; Nemoto, T.; Kurata, H., Sub-picometer Sensitivity and Effect of Anisotropic Atomic Vibrations on Ti L2,3-Edge Spectrum of
SrTiO3, Appl. Phys. Lett., 119, [232901-1]-[232901-5] (2021). Featured Article
Iwashimizu, C.; Haruta, M.; Kurata, H., Electron Orbital Mapping of SrTiO3 Using Electron Energy-Loss Spectroscopy, Appl. Phys. Lett., 119,[232902-1]-[232902-5] (2021). Editor’s Pick

46

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Different Atomic Contrasts in HAADF
Images and EELS Maps of Rutile TiO2
High-angle annular dark-field (HAADF) imaging and elemental mapping at the atomic scale by scanning transmission
electron microscopy (STEM) combined with electron energyloss spectroscopy (EELS) are widely used for material characterization. Recently, theoretical and experimental electron
orbital mapping using STEM-EELS has been reported. Quantitative understanding of the contrast of the image is important
to discuss the anisotropy of the orbital in an EELS map.
Figure 1 shows an experimental HAADF image withsimultaneously measured Ti-L2,3 and O-K elemental maps andthe simulated elemental maps. Only the Ti atomic columns arevisualized in the HAADF image due to its Z-contrast nature.
The Ti and O elemental map measured using EELS show therespective atomic columns (Fig. 1c and d). The O map shows
the distorted projected octahedral structure that agrees withthe structure model (Fig. 1a), and the atomic shape is an isotropic distribution. On the other hand, the shape of the atom in
the Ti map shows an anisotropic elliptical distribution that
extends along the long axis of the octahedron, even though the
HAADF image does not show such anisotropic contrast.
Figures 1e and 1f show the simulated images of O and Ti
elemental maps for the same sample thickness as experiment(32 nm). The Ti L2,3-map shows anisotropic atomic shapealong the long axis of the octahedron like the experimental
one. This indicates that Ti maps of TiO2 can show an anisotropic
elliptical shape, regardless of the anisotropic electron orbital,
because the simulation program (μSTEM) assumes (isotropic)
isolated atoms without bonding character. We investigatedthe electron channeling process to elucidate the cause of thedifference of the Ti atomic shape between the HAADF image
and Ti L2,3-map. Figure 2 shows the probe intensity propagating along the [001] axis of a rutile TiO2 crystal as a function of
the thickness, where the cross-section image is observed fromthe [110] direction along the black line indicated in Fig. 1.
Figure 2a–e corresponds to the probe positions as numberedon the top. When the probe is located on a Ti (Fig. 2a and e) or
O (Fig. 2c) column, strong electron channeling occurs, bywhich the incident electrons travel straight along each column.
In the case of position 2 (Fig. 2b), the probe incident near an
O column is quickly channeled onto the nearby oxygen atomic
column. This can be confirmed by the high intensity in the O
elemental map (Fig. 1c and 1e) and the low intensity in the Ti
elemental map (Fig. 1d and 1f) at the yellow position, whichcorresponds to probe position 2. On the other hand, in the caseof position 4 (Fig. 2d), the probe incident near a Ti column isalso channeled onto a nearby Ti column. Therefore, the Ti L2,3edge is highly excited at position 4 due to the delocalization of
inelastic scattering (Fig. 2d), whereas the excitation is suppressed at position 2 due to channeling onto the nearby
oxygen column (Fig. 2b). It is considered that these processes
are main reason for the anisotropic contrast in Ti L2,3-map.
It is shown that considering the anisotropic shape of Ti
atomic column observed in the Ti elemental map is essential
for the quantification and visualization of electron orbitals.
Consequently, much care must be taken in interpreting EELS
maps.

Figure 1. (a) Projected structure model of rutile TiO2 along the [001] axis.
The dashed line shows the unit cell. The lengths of the long and short
Ti–O bond in the projected TiO6 octahedron is written. (b) Accumulated
experimental HAADF image. Elemental maps of (c) O K- and (d) Ti
L2,3-edges. Simulated elemental maps of (e) O K- and (f) Ti L2,3-edges.
The black lines in (b–f) and colour points correspond to the probe positions in Fig. 2.

Figure 2. Probe intensity as a function of thickness in the [001]-oriented
rutile TiO2 crystal, where the cross-section image was observed from the[110] direction along the black lines indicated in Fig. 1. The electronprobes are located on each triangle labelled 1–5, which correspond to thecoloured dots in Fig. 1. (a, e) Probe located on the Ti column and (c) on
the O column. The distances between positions 1 and 2 and between positions 4 and 5 are the same. This distance corresponds to the half width at
half maxima of the short axis of the elliptical shape of the Ti map. Ti andO atoms are indicated as blue and red circles, respectively.

ICR ANNUAL REPORT, 2023

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Advanced Research Center for Beam Science– Atomic and Molecular Structures –https://www.scl.kyoto-u.ac.jp/~fujii/indexE.html

Assist Prof
FUJII, Tomomi(D Sc)

Scope of ResearchThis laboratory analyzes X-ray crystallographic structures of biological macromolecules and studies the structural ­biology about the relationships between protein
structures and their functions and properties based on the crystal structures. The main
research themes are elucidation of the reaction mechanism of enzymes, the relationship between the multiform conformation and the functional variety of proteins, thestructural basis for the domain-arrangements of multi-domain proteins or protein-­protein interactions, structure determination for structure-based protein engineeringand industrial application, and the adaptation strategy of proteins from thermophilicor cold-adapted bacteria.

KEYWORDS
Crystal
X-ray Crystallographic Analysis
Structural Biology
Protein Crystallography
Structure and Function

Recent Selected Publications
Fujii, T.; Sato, A.; Okamoto, Y.; Yamauchi, T.; Kato, S.; Yoshida, M.; Oikawa, T.; Hata, Y., The Crystal Structure of Maleylacetate Reductase
from Rhizobium sp. Strain MTP-10005 Provides Insights into the Reaction Mechanism of Enzymes in Its Original Family, Proteins: Structure,
Function, and Bioinformatics, 84, 1029-1042 (2016).
Fujii, T.; Yamauchi, T.; Ishiyama, M.; Gogami, Y.; Oikawa, T.; Hata, Y., Crystallographic Studies of Aspartate Racemase from Lactobacillus
sakei NBRC 15893, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 71, 1012-1016 (2015).
Fujii, T.; Goda, Y.; Yoshida, M.; Oikawa, T.; Hata, Y., Crystallization and preliminary X-ray Diffraction Studies of Maleylacetate Reductase
from Rhizobium sp. Strain MTP-10005, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 64, 737-739 (2008).
Fujii, T.; Oikawa, T.; Muraoka, I.; Soda, K.; Hata, Y., Crystallization and Preliminary X-ray Diffraction Studies of Tetrameric Malate Dehydrogenase from the Novel Antarctic Psychrophile Flavobacterium frigidimaris KUC-1, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 63,
983-986 (2007).
Fujii, T.; Sakai, H.; Kawata, Y.; Hata, Y., Crystal Structure of Thermostable Aspartase from Bacillus sp. YM55-1: Structure-based Explorationof Functional Sites in the Aspartase Family, J. Mol. Biol., 328, 635-654 (2003).

48

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Refined Crystal Structure of the Oxygenase
Component (GraA) of Resorcinol Hydroxylase
Resorcinol hydroxylase is involved in the first step of
the resorcinol catabolic pathway and catalyzes the hydroxylation of resorcinol to hydroxyquinol. This enzyme belongs to the two-component flavin-diffusible monooxygenase(TC-FDM) family and comprises two components: anoxygenase and a flavin reductase. It uses molecular oxygen
and reduced flavin for hydroxylation and NAD(P)H for
flavin reduction. The smaller component, flavin reductase,generates reduced flavin to allow the oxygenase component
to oxygenate the substrate. Thus, the enzymatic reaction is
executed in two steps. However, hydroxylation activity
requires cooperation between both the components. To understand the structural basis of the catalytic mechanism, we
performed a crystal structure analysis of the apo-form of
the oxygenase component (GraA) from Rhizobium sp. strain
MTP-10005. GraA is a tetramer, and its subunit consists of
409 amino acid residues with a mass of 43,305 Da.
N-terminal His-tagged GraA was used for crystallization.
The protein solution consisted of 5 mg/ml GraA and 50
mM Tris-HCl pH 8.0. Crystals with suitable sizes for X-ray
diffraction experiments were obtained over several days bya sitting drop vapor diffusion method, with a reservoir
solution consisting of 17% (w/v) PEG3350 and 0.2 M
K2HPO4. They belonged to the tetragonal space group
I4122 with unit cell dimensions of a = b = 101.6 Å, c =319.8 Å and contained one GraA subunit in asymmetricunit. Diffraction data were collected up to 1.9 Å resolution
under cryogenic conditions at beamline BL5A, PF, Tsukuba,
Japan. The structure was determined by molecular replacement and refined at 1.9 Å resolution up to R = 0.162 andRfree = 0.185.
GraA is a tetramer of four identical subunits related to
one another by three molecular two-fold axes which are
identical to crystallographic two-fold axes (Figure 1). A
given pair of two subunits in the molecule forms a close
dimer and two of the close dimers form a loose dimer. The
GraA tetrameric molecule adopts the structure of a dimerof dimers. The subunit consists of three domains (Figure2). The N-terminal domain (residues Met1–Ala121) has an
α-structure mainly of antiparallel α-helices, the central
domain has a β-structure of two β-sheets stacked together,and the C-terminal domain (residues Phe218–Tyr409) has
a four-helix-bundle structure of long antiparallel α-helices
involved in tetramer formation. The part of PEG3350 used
as a precipitating agent for the crystallization is located in
the space that is encompassed by these three domains(Figure 2). The PEG binds to both the binding site of a
portion of isoalloxazine ring of FAD in the GraA-FAD
complex and the putative substrate binding site (Figure 3).
The loop region of 13 residues (residues Gly271–Asn283),
which is ordered and covers the FAD of another subunit in
the GraA-FAD complex, is disordered in this apo-form(Figures 2 and 3).

Figure 1. Tetrameric molecular structure of the apo-form of the oxygenase
component of resorcinol hydroxylase (GraA) from Rhizobium sp. strain
MTP-10005 with bound PEG.

Figure 2. Subunit structure of the apo-form of the oxygenase componentof resorcinol hydroxylase (GraA) from Rhizobium sp. strain MTP-10005
with bound PEG.

Figure 3. Structure of the active site cleft of the apo-form of the oxygenase
component of resorcinol hydroxylase (GraA) from Rhizobium sp. strain
MTP-10005 with bound PEG.

ICR ANNUAL REPORT, 2023

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International Research Center for Elements Science– Synthetic Organotransformation –https://www.scl.kyoto-u.ac.jp/~elements/en/

Prof
Assoc Prof
Senior Lect
NAKAMURA, Masaharu ISOZAKI, Katsuhiro PINCELLA, Francesca(D Sc)(D Eng)(D Eng)Students
LU, Siming (D4)ISERI, Kenta (D1)
YIN, Haozhi (D1)
WU, Beiling (D1)
GO, Touran (D1)
CHEN, Litian (M2)
KIHARA, Ayako (M2)

Program-Specific Assist ProfMINEO, Keito(D Agr)Researchers (pt)
IMAI, Makiko
MATSUMURA, Hiroyuki
AOKI, Satoshi

Assist Prof
DOBA, Takahiro(D Sc)

Program-Specific Assist Prof
NAKAGAWA, Yuka
(D Sc)SAITO, Ryohei (M2)
UEDA, Kyosuke (M1)
SHIKAMI, Satoshi (M1)
ZHANG, Hao (RS)TAKARAKO, Masataka (UG)
TAKEUCHI, Soshi (UG)

AVENA, Ramon Francisco Bernardino
NAKAMURA, Yuki

Assist Techn Staff
FUKUMOTO, Koto

Scope of Research
Our research activity focuses on the development of new moleculartransformations, which can contribute to better or ideal synthesis offunctional molecules as well as to exploitation of new chemical(metal and carbon) resources. The present research subjects are (1)metal-catalyzed carbon–carbon and carbon–heteroatom bond forming
reactions by using universal metals such as iron (2) developmentof small metallic nanocluster catalysts based on supramolecularapproaches (3) utilization of woody biomass as the renewablecarbon resources by mild catalytic transformations of wood molecules into useful compounds and materials.

KEYWORDS
Iron Catalysis

Organotransformation

Woody Molecular Transformation

Supramolecular & Superatomic Catalysis

Recent Selected Publications
Isozaki, K.; Iseri, K.; Saito, R.; Ueda, K.; Nakamura, M., Dual Catalysis of Gold Nanoclusters: Photocatalytic Cross‐Dehydrogenative
Coupling by Cooperation of Superatomic Core and Molecularly Modified Staples, Angew. Chem. Int. Ed. (in press).
Nakajima, S.; Hashimoto, T.; Lu, S.; Hashizume, D.; Matsuda, H.; Hatakeyama, T.; Isozaki, K.; Takaya, H.; Nakamura, M., SciPROP-R: An
Effective Bisphosphine Ligand for the Chemo-selective Iron-Catalyzed Suzuki–Miyaura Coupling of Alkyl Chlorides, Bull. Chem. Soc. Jpn.
(in press).
Isozaki, K.; Ueno, R.; Ishibashi, K.; Nakano, G.; Yin, H.; Iseri, K.; Sakamoto, M.; Takaya, H.; Teranishi, T.; Nakamura, M., Gold Nanocluster
Functionalized with Peptide Dendron Thiolates: Acceleration of the Photocatalytic Oxidation of an Amino Alcohol in a Supramolecular
Reaction Field, ACS Catal., 11, 13180-13187 (2021).
Adak, L.; Jin, M.; Saito, S.; Kawabata, T.; Itoh, T.; Ito, S.; Sharma, A. K.; Gower, N. J.; Cogswell, P.; Geldsetzer, J.; Takaya, H.; Isozaki, K.;
Nakamura, M., Iron-Catalysed Enantioselective Carbometalation of Azabicycloalkenes, Chem. Commun., 57, 6975-6978 (2021).
Agata, R.; Takaya, H.; Matsuda, H.; Nakatani, N.; Takeuchi, K.; Iwamoto, T.; Hatakeyama, T.; Nakamura, M., Iron-Catalyzed Cross Couplingof Aryl Chlorides with Alkyl Grignard Reagents: Synthetic Scope and FeII/FeIV Mechanism Supported by X-Ray Absorption Spectroscopy
and Density Functional Theory Calculations, Bull. Chem. Soc. Jpn., 92, 381-390 (2019).

50

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Iron-Catalyzed Organic Synthesis
Development of organic transformations using earth
abundant transition-metals is becoming more and more
important in recent years. Our group focuses on use of iron
as a catalyst, and so far developed a variety of iron-catalyzed
cross-coupling reactions, some of which can’t be achievedby conventional transition-metal catalysts such as palladium.
As a recent representative example, we developed a newbisphosphine ligand, SciPROP-R which enables facileiron-catalyzed Suzuki-type cross-coupling between alkyl
chlorides and arylboronates. Based on the mechanistic
studies, we proposed a catalytic cycle in which SciPROP-R
ligand facilitates the smooth halogen abstraction fromalkyl chlorides. Also, we have developed a magnetite
nanoparticle-catalyzed oxidation reaction of primary andsecondary alcohols assisted by microwave irradiation(Figure 1). Magnetite nanoparticles have the additional
advantage of being easily recoverable from the reaction
mixture by magneto-separation, which allows them to be
successively recycled several times with negligible loss inactivity.

and 4) utilization of plasmonic resonance with light. As arecent representative example, we reported a new findingof dual catalytic property of gold nanoclusters originatingfrom two structural components, superatomic core and surrounding staples. The cooperative catalysis enables the
cross coupling between photooxidized iminium intermediates and alkynyl-gold species, providing propargylamine
derivatives.

Figure 2. Dual catalysis of gold nanoclusters toward photocatalytic
cross-dehydrogenative coupling between tertiary amines and terminal
alkynes.

Wood Molecular Transformation

Figure 1. Microwave-assisted oxidation of alcohols catalyzed by ironoxide nanoparticles.

Supramolecular & Superatomic Catalysis
This project focuses on the development of highly active
and selective metallic nanoparticle and cluster catalysts. To
achieve this purpose, four key methodologies have beendeveloped: 1) creation of reaction field with advanced
self-assembly, 2) design of selective molecular transformation with multi-points intermolecular interaction, 3) size
selective synthesis of metallic nanoparticles and clusters,

Woody biomass is renewable and the most abundant
carbon resource on the earth, thus expected to utilize as afeedstock to chemicals and energy toward a sustainable
society. This project focuses on the chemical transformation of woody biomass into useful materials under mild
catalytic conditions. To achieve this purpose, we havedeveloped two key technologies; 1) direct transformationof woody lignin to fluorescent molecules, 2) one-pot disintegration of wood powder into nanocellulose. As a recent
representative example, we reported the development ofartificial urushi-coating materials by installing trienyl side
chains from natural linolenic acid to the bio-renewablephenoxypropanone compounds obtained from enzymatic
degradation of woody lignin.

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International Research Center for Elements Science– Advanced Solid State Chemistry –https://www.scl.kyoto-u.ac.jp/~shimakgr/indexE.html

Prof
SHIMAKAWA, Yuichi(D Sc)

Assoc Prof
KAN, Daisuke(D Sc)

Assist Prof
GOTO, Masato(D Sc)

Techn Staff
ICHIKAWA, Noriya(D Eng)Students
IIHOSHI, Makoto (D2)ISODA, Yosuke (D2)SHEN, Yufan (D2)

XIE, Lingling (D2)CHEN, Chen (D2)WATANABE, Rei (D1)

ITO, Mayuri (M1)
FUJI, Souta (M1)

Scope of Research
Transition metal oxides have a wide variety of interesting
and useful functional properties, including electronic conduction, superconductivity, ferroelectricity, and ferromagnetism.
In fact, some of these ­oxides are used in current electronic­devices. Our research mainly ­focuses on perovskite-structured
transition metal oxides with novel functional properties due tocomplex couplings between their lattices, charges and spins.
We are currently exploring such functional oxides with advanced oxide-synthesis techniques such as high-pressure synthesis and epitaxial thin film growth.

KEYWORDS
Solid State ChemistryHigh Pressure Synthesis
Heterointerface

Functional Metal Oxides
Epitaxial Thin Film Growth

Recent Selected Publications
Iihoshi, M.; Goto, M.; Kosugi, Y.; Shimakawa Y., Cascade Charge Transitions of Unusually High and Mixed Valence Fe3.5+ in the A-Site
Layer-Ordered Double Perovskite SmBaFe2O6, J. Amer. Chem. Soc., 145, 10756-10762 (2023).
Kamada, T.; Ueda, T.; Fukuura, S.; Yumura, T.; Hosokawa, S.; Tanaka, T.; Kan D.; Shimakawa Y., Ultralong Distance Hydrogen Spillover
Enabled by Valence Changes in a Metal Oxide Surface, J. Am. Chem. Soc., 145, 1631-1637 (2023).
Chen, C.; Kosugi, Y.; Goto, M.; Shimakawa Y., Thermal Properties and Phase Transition Behaviors of Possible Caloric Materials
Bi0.95Ln0.05NiO3, J. Mater. Chem. A, 10, 15389-15393 (2023).
Shimakawa Y.; Kosugi Y., Giant Caloric Effects in Charge-Spin-Lattice Coupled Transition-Metal Oxides, J. Mater. Chem. A, 11, 12695-12702(2023).
Isoda, Y.; Kan, D.; Majima, T.; Shimakawa Y., Orientation-Dependent Electrochemical Reduction and Proton Evolution in the OxygenDeficient Perovskite SrFeO2.5+y, Appl. Phys. Express, 16, 015506/1-5 (2023).

52

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Cascade Charge Transitions of UnusuallyHigh and Mixed Valence Fe3.5+ in the A‑Site
Layer-Ordered Double Perovskite SmBaFe2O6

Ultralong Distance Hydrogen Spillover
Enabled by Valence Changes in a Metal
Oxide Surface

Phase transitions caused by relieving of charge instability
are one of the most important and interesting phenomena
in solid state chemistry and condensed matter physics. A
typical example was found in Fe3O4, and the transition isoften called the Verwey transition. It occurs when the
instability of a mixed valence state of Fe2.5+ at the B site of
the spinel-type crystal structure is relieved, resulting incharge-ordered states of Fe2+ and Fe3+, with an accompanying metal-to-insulator transition. Another phase transition
caused by relieving charge instability is seen in compounds
containing an unusually high valence state of ions. The
typical example is Fe4+ seen in the perovskite-type structured CaFeO3. Fe4+ in CaFeO3 shows charge disproportionation to Fe3+ and Fe5+ in a rock-salt manner, whichaccompanies a metal-to-insulator transition. We are thenvery interested in the phase transition behaviors of a compound containing ions in both unusually high and mixed
valence states. To prepare such a compound, in this work,
we used the A-site layer-ordered oxygen-deficient precursor SmBaFe2O5, which contains the mixed valence stateof Fe2.5+ ions. By topochemically oxidizing the compoundto fully incorporate oxygen ions into the vacant sites, theA-site layer-ordered double perovskite SmBaFe2O6 withthe unusually high and mixed valence state of Fe3.5+ was
obtained. We have found that cascade phase transitions
are induced in SmBaFe2O 6 to relieve the charge instability, described as SmBaFe3.5+2O6→SmBa(Fe3+Fe4+)O6→
SmBa(Fe3+Fe(4‑δ)+0.5Fe(4+δ)+0.5)O6→SmBa(Fe3+1.5Fe5+0.5)O6.
The first Verwey-like charge-order transition occurred at
340 K and was accompanied by a significant structuralchange and a sudden increase in magnetic susceptibility.
The following transition was the charge disproportionationof metastable Fe4+ to Fe3+ and Fe5+, and each of the spins
resulted in the antiferromagnetic ground state.

The surface of metal oxides is a fertile platform forchemical reactions and an important subject of investigation.
However, experimentally characterizing and understanding
surface reactions are challenging, especially when hydrogenis involved in chemical reactions on oxides’ surfaces. The
occurrence of hydrogen spillover on oxide surfaces has
been established since its discovery in 1964. Furthermore,this phenomenon has been utilized as a reaction routefor producing functional materials. Nonetheless, thefundamental characteristics of hydrogen spillover remain
elusive. This is because of experimental difficulties inobserving hydrogen during chemical reactions. In addition,
reaction systems utilizing hydrogen spillover are complex
and not well defined. Delineating hydrogen reactions anddiffusion on oxide surfaces therefore requires proper designand construction of model (or ideal) reaction systems without such complexities. Recent progress in nanometer-levelmaterial techniques enables the fabrication of well-definedmodel catalytic systems with separated functions. The
model systems, consisting of epitaxial films of catalyticoxide supports and metal catalysts located at controlled
positions on the supports’ surfaces, are useful for evaluating various phenomena associated with (electro) chemical
reactions. Since catalytic supports are reduced in the hydrogen spillover process, tracking hydrogen-spilloverinduced changes in model systems enables the “visualization”
of hydrogen. Here, in this study, we fabricated catalytic
model systems based on Pd-loaded SrFeOx (x~2.8) epitaxial
films and investigated hydrogen spillover. We show thathydrogen spillover on the SrFeOx support extends overlong distances (~600 μm). Furthermore, the hydrogenspillover-induced reduction of Fe4+ in the support yields
large energies (as large as 200 kJ/mol), leading to the spontaneous hydrogen transfer and driving the surprisingly
ultralong hydrogen diffusion. These results show that thevalence changes in the supports’ surfaces are the primaryfactor determining the hydrogen spillover distance.

Figure 1. Crystal structure of the topochemically oxidized double perovskite
SmBaFe2O6 and temperature dependence of magnetic susceptibility of
SmBaFe2O6.

Figure 2. Schematic drawing of ultralong distance hydrogen spillover on
SrFeOx.

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International Research Center for Elements Science– Organometallic Chemistry –https://www.om.kuicr.kyoto-u.ac.jp/

Prof
OHKI, Yasuhiro(D Eng)Assist ProfTANIFUJI, Kazuki(D Sc)

Assist ProfHIGAKI, Tatsuya(Ph D)

Assist Techn Staff

Students

FUJISAKI, Yoshie

KATO, Itsuki (M2)
MATSUOKA, Yuto (M2)
TANAKA, Kanata (M2)
SHIMOYAMA, Sayaka (M1)

Program-Specific Res
PD (JSPS)IZU, Hitoshi
JAYAKUMAR, Sanjeevi(D Sc)(Ph D)SUNAMI, Kohei (M1)HOSHI, Yutaro (UG)
NAKAGAWA, Hiromu (UG)
WATANABE, Rin (UG)

Scope of Research
Developing efficient energy storage systems and innovative material production processes is a significant challenge forchemists to contribute to a sustainable society. We plan to approach these problems by using transition metal clusters ofwhich multiple metal atoms work together as catalysts and functional materials. Our laboratory focuses explicitly on
creating a new method to synthesize the clusters with atomic precision and applying the obtained clusters to difficult
reactions such as the reduction of CO2 and N2.

KEYWORDS
Transition Metal Clusters
Homogeneous Catalysis
Nitrogen Fixation
Bioinorganic Chemistry

Recent Selected Publications
Izu, H.; Bhave, D. G.; Matsuoka, Y.; Sameera, W. M. C.; Tanifuji, K.; Ohki, Y., Synthesis, Characterization, and Catalytic Activity of a Cubic[Mo3S4Pd] Cluster Bearing Bulky Cyclopentadienyl Ligands, Eur. J. Inorg. Chem., 26, e202300399 (2023).
Ohki, Y.; Munakata, K.; Matsuoka, Y.; Hara, R.; Kachi, M.; Uchida, K.; Tada, M.; Cramer, R. E.; Sameera, W. M. C.; Takayama, T.; Sakai, Y.;
Kuriyama, S.; Nishibayashi, Y.; Tanifuji, K., Nitrogen Reduction by the Fe Sites of Synthetic [Mo3S4Fe] Cubes, Nature, 607, 86-90 (2022).
Lee, C. C.; Kang, W.; Jasniewski, A. J.; Stiebritz, M. T.; Tanifuji, K.; Ribbe, M. W.; Hu, Y., Evidence of Substrate Binding and Product Release
via Belt-Sulfur Mobilization of the Nitrogenase Cofactor, Nat. Catal., 5, 443-454 (2022).
Tanifuji, K.; Sakai, Y.; Matsuoka, Y.; Tada, M.; Sameera, W. M. C.; Ohki, Y., CO Binding onto Heterometals of [Mo3S4M] (M = Fe, Co, Ni)
Cubes, Bull. Chem. Soc. Jpn., 95, 1190-1195 (2022).
Tanifuji, K.; Ohki, Y., Metal-Sulfur Compounds in N2 Reduction and Nitrogenase-Related Chemistry, Chem. Rev., 120, 5194-5251 (2020).

54

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Catalytic N2 Silylation by the Fe Sites of
Cuboidal [Mo3S4Fe] Clusters

Tracing the S Incorporation into the
Nitrogenase Cofactor Precursor

Biological N2 fixation is conducted by nitrogenase that
employs a unique Fe/Mo-S-C cluster as its catalytic site
(FeMoco, [(R-homocitrate)MoFe7S9C]). Synthetic counterparts of the FeMoco, metal-sulfur clusters, demonstrated
capturing N2 on rare occasions; nevertheless, the catalytic
conversion of this stable molecule has not been achieved
despite its relevance to the biological N2 fixation. This
study focuses on capture, activation, and catalytic conversion of N2 by an Fe atom incorporated into our [Mo3S4]
incomplete-cubane platform bearing bulky Cp ligands.
Treatment of these clusters with excess Na and ClSiMe3
under a N2 atmosphere gave N(SiMe3)3 with up to 248 eq.
per cluster. This work exemplifies the N2-reducing capability of Fe atoms in a S-rich environment, which biologicalsystems have selected to achieve a similar purpose. Further
studies are ongoing to unveil the effect of an incorporated
metal atom (Fe vs Co or Ni) on catalytic N2 silylation.

FeMoco is arguably one of the most complex metallocofactors in Nature. Its biosynthetic pathway is correspondingly complicated and remains unclear, which hampers
applications of this enzyme toward artificial N2 fixation. In
this study, we investigated an enzymatic process by which
FeMoco precursor (L-cluster, [Fe8S9C]) is generated fromtwo [Fe4S4] clusters on the protein by using a semi-synthetic
approach. The study revealed that this process includes a S
atom uptake from SO32– and that the S atom is replaceablewith homologous elements (Se, Te). Moreover, we succeededin selective observation of the incorporated elements andtheoretical simulations supporting the reactions’ feasibility.
These results show that nitrogenase requires an S source as
an external substrate for its function.

Figure 2. Schematic description of a sulfur uptake from sulfite (SO32–) inthe biosynthetic pathway of FeMoco.

Figure 1. Proposed N2 binding state of FeMoco and a N2-bound Mo-Fe-Scluster.

ICR ANNUAL REPORT, 2023

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International Research Center for Elements Science– Nanophotonics –https://www.scl.kyoto-u.ac.jp/~opt-nano/en/index.html

Prof
Assoc ProfKANEMITSU, Yoshihiko HIRORI, Hideki(D Eng)(D Sc)

Assist ProfYUMOTO, Go(D Sc)

Program-Specific Assist Prof Program-Specific Assist ProfSEKIGUCHI, Fumiya YAMADA, Takumi(D Sc)(D Sc)

Students
CHO, Kenichi (D3)NAKAGAWA, Kotaro (D3)ZHANG, Zhenya (D3)HIGASHIMURA, Chika (D2)DAIKOKU, Yusuke (M2)MARUYAMA, Kei (M2)

Scope of Research
Our research interest is to understand optical and quantum
properties of nanometer-structured materials and to ­establish
opto-nanoscience for creation of innovative functional materials. Space- and time-resolved laser spectroscopy is used to
study optical properties of semiconductor quantum nanostructures and strongly correlated electron systems in low-­dimensional materials. The main subjects are as follows: 1)
investigation of optical properties of single nanostructures
through the development of a high-resolution optical microscope, 2) ultrafast optical spectroscopy of excited states ofsemiconductor nanostructures, 3) photophysics of solar cellmaterials, and 4) engineering material properties with lights.

KEYWORDS
Femtosecond Laser Spectroscopy
Quantum DotsHigh Harmonic Generation

Single Photon Spectroscopy
Perovskites

Recent Selected Publications
Zhang, Z.; Sekiguchi, F.; Moriyama, T.; Furuya, S. C.; Sato, M.; Satoh, T.; Mukai, Y.; Tanaka, K.; Yamamoto, T.; Kageyama, H.; Kanemitsu,
Y.; Hirori, H., Generation of Third-Harmonic Spin Oscillation from Strong Spin Precession Induced by Terahertz Magnetic Near Fields, Nature
Commun., 14, [1795-1]-[1795-7] (2023).
Nakagawa, K.; Hirori, H.; Sato, S. A.; Tahara, H.; Sekiguchi, F.; Yumoto, G.; Saruyama, M.; Sato, R.; Teranishi, T.; Kanemitsu, Y., Size-Controlled
Quantum Dots Reveal the Impact of Intraband Transitions on High-Order Harmonic Generation in Solids, Nature Phys., 18, 874-878 (2022).
Handa, T.; Hashimoto, R.; Yumoto, G.; Nakamura, T.; Wakamiya, A.; Kanemitsu, Y., Metal-Free Ferroelectric Halide Perovskite Exhibits
Visible Photoluminescence Correlated with Local Ferroelectricity, Sci. Adv., 8, [eabo1621-1]-[eabo1621-8] (2022).
Yumoto, G.; Hirori, H.; Sekiguchi, F.; Sato, R.; Saruyama, M.; Teranishi, T.; Kanemitsu, Y., Strong Spin-Orbit Coupling Inducing Autler-Townes
Effect in Lead Halide Perovskite Nanocrystals, Nature Commun., 12, [3026-1]-[3026-7] (2021).
Sekiguchi, F.; Hirori, H.; Yumoto, G.; Shimazaki, A.; Nakamura, T.; Wakamiya, A.; Kanemitsu Y., Enhancing the Hot-Phonon Bottleneck
Effect in a Metal Halide Perovskite by Terahertz Phonon Excitation, Phys. Rev. Lett., 126, [077401-1]-[077401-6] (2021).

56

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
The Second- and Third-Harmonic Generationfrom Spin Precession in a Canted Antiferromagnet
Recently, antiferromagnetic spintronics is considered as
one of the important next-generation information technologies, owing to the low-loss and non-volatility of spin
properties. Therefore, the spin dynamics in antiferromagnets with the resonance at terahertz (THz) frequencies, has
attracted much interest. However, because of the lack ofstrong THz magnetic fields, the THz spin dynamics has not
yet been well understood. In this study, we developed anovel micro-resonator to efficiently enhance the magnetic
component of THz wave, which allows the generation of
the world’s strongest THz magnetic field up to 2 Tesla inan antiferromagnet HoFeO3.1) By using this strong THz
magnetic field, we succeeded in inducing the unprecedentedly
large magnetization change and thus generating the second
and third harmonics of fundamental spin frequency (Fig.
1), for the first time. Furthermore, our research provides a
deep understanding of relationship between the harmonics
and the spin structure. The efficient excitation method ofspin dynamics and the understanding of nonlinear spin
dynamics can help us establish novel nonlinear spintronics
at terahertz frequencies.

Figure 1. Spectrum of spin dynamics. Different colors indicate different
excitation powers.

Size-Dependent Structural Phase Transitionin Single Lead Halide Perovskite Nanocrystals
Lead halide perovskite nanocrystals (NCs) have attracted
attention as a new light-emitting material because of theirhigh photoluminescence (PL) quantum yields and bandgap
tunability around the whole visible region. Halide perovskites
have three crystal structures (orthorhombic, tetragonal, andcubic), and the PL peak energy depends strongly on the
crystal structure. However, it is unclear how the NC size
affects the phase transition temperature. In this study, weinvestigated the temperature dependence of the PL spectrain single perovskite APbBr3 (A = FA (HC(NH2)2) and Cs)
NCs from 5.5 to 200 K using single-dot PL spectroscopy.2)
For FAPbBr3 NCs, a redshift in PL peak energy due to theorthorhombic to tetragonal phase transition is observed
between 100 and 150 K, while CsPbBr3 NCs show nophase transition within the observed temperature range. We
found that the phase transition temperature decreases insmaller FAPbBr3 NCs (Fig. 2).

Figure 2. Size dependent orthorhombic-to-tetragonal phase transition
temperature (TOT) in FAPbBr3 NCs.

Anomalous Band-Edge Optical Responses ina Two-Dimensional Ferroelectric Halide
Perovskite
In two-dimensional (2D) halide perovskites, electrons
and holes confined in atomically thin 2D perovskite layers
form excitons with extremely large binding energies. The
peculiar optical properties emerge from such stable excitons.
In addition, because the lattice distortion of the perovskite
structure can be controlled by the organic molecular cations
contained in 2D halide perovskites, the unique structuralproperties appear: Large lattice distortion introduced bylarge-sized organic cations results in the emergence offerroelectricity in 2D halide perovskites. Therefore, clarifying
the correlation between the crystal structure and opticalproperties is important for understanding the physicalproperties of ferroelectric halide perovskites and developing new devices. In this study, we measured the temperaturedependences of the absorption spectra, second harmonic
generation (SHG) intensity, and lattice constants of 2D
ferroelectric perovskite (BA)2(EA)2Pb3I10 single crystals(BA is n-butylammonium and EA is ethylammonium).3)
We found the anomalous temperature behavior of the
Urbach tail of the absorption spectrum exhibiting a significant change at around 200 K. We revealed that this change
is correlated with the temperature dependences of the SHG
intensity and the in-plane lattice distortion. We concluded
that the randomness of the ferroelectric polarizations
modifies the linewidth of the band-edge exciton transitionand leads to the anomalous temperature dependence of thesteepness parameter of the Urbach tail.
References
1) Z. Zhang, F. Sekiguchi, T. Moriyama, S. C. Furuya, M. Sato, T. Satoh,
Y. Mukai, K. Tanaka, T. Yamamoto, H. Kageyama, Y. Kanemitsu, and H.
Hirori, Nature Commun. 14, 1795 (2023).
2) K. Cho, T. Yamada, M. Saruyama, R. Sato, T. Teranishi, and Y. Kanemitsu,
J. Chem. Phys. 158, 201104 (2023).
3) C. Higashimura, G. Yumoto, T. Yamada, T. Nakamura, F. Harata, H.
Hirori, A. Wakamiya, and Y. Kanemitsu, J. Phys. Chem. Lett. 14, 8360
(2023).

ICR ANNUAL REPORT, 2023

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Bioinformatics Center– Chemical Life Science –https://cls.kuicr.kyoto-u.ac.jp/en/

Prof
OGATA, Hiroyuki(D Sc)

Assoc Prof
ENDO, Hisashi(D Environmental Science)

Assist ProfOKAZAKI, Yusuke(D Sc)

Assist Prof *Distinguished Visiting Assoc ProfHIKIDA, Hiroyuki HINGAMP, Pascal Michel(D Agr)(Ph D)

Proj ResNGUYEN, Thi Tuyen
OKUDA, Shiho
YAMAGISHI, Yuki

Assist Techn Staff
Program-Specific Res
SATO, Takuya(D Agr)Students

Program-Specific Res
Res (pt)
MENG, Lingjie
NECHES, Russell Young(Ph D)

XIA, Jun (D3)
BAN, Hiroki (D3)ZHANG, Ruixuan (D2)
YANG, Qingwei (D2)WU, Junyi (D1)

LIU, Wenwen (D1)ZHANG, Liwen (M2)
CHEN, Jingjie (M2)
FANG, Yue (M2)
ZHAO, Hongda (M1)

Guest Res Assoc
GONG, Chunjie(D Agr)NAGASAKA, Koumei (M1)
TANG, Wei (M1)KIKUYA, Saki (M1)
YU, Zhaoxi (RS)SASAKI, Hiroto (UG)

OGATA, Yuki
*New Research Field
Development Project

HONDA, Naoki (UG)
QIN, Hongwei**Short-Term International Student

Scope of Research
We are interested in understanding the functioning and evolution of
biological systems at varying scales from tiny microbes up to the
Earth’s environment, by leveraging rapidly accumulating big data inlife science and bioinformatics approaches. We currently focus on 1)
the evolution of viruses and their links to the origin of life, 2) microbial ecology in different ecosystems, and 3) the development of bioinformatics methods and biological knowledge resources for biomedical and industrial applications. To fuel these research activities, wetake part in environmental sampling campaigns such as Tara Oceans.
Our resources and developed tools are accessible through GenomeNet(www.genome.jp) to scientific communities and the public.

KEYWORDS

GenomeNet

Bioinformatics

Environmental Genomics

Virology

Molecular Evolution

Recent Selected PublicationsGaïa M.; Meng L.; Pelletier E.; Forterre P.; Vanni C.; Fernandez-Guerra A.; Jaillon O.; Wincker P.; Ogata H.; Krupovic M.; Delmont, T. O.,
Mirusviruses Link Herpesviruses to Giant Viruses, Nature, 616, 783-789 (2023).
Hikida H.; Okazaki Y.; Zhang R.; Nguyen T. T.; Ogata H., A Rapid Genome-Wide Analysis of Isolated Giant Viruses only Using MinION
Sequencing, Environ. Microbiol., 25 (11), 2621-2635 (2023).
Ban H.; Sato S.; Yoshikawa S.; Yamada K.; Nakamura Y.; Ichinomiya M.; Sato N.; Blanc-Mathieu R.; Endo H.; Kuwata A.; Ogata H., Genome
Analysis of Parmales, a Sister Group of Diatoms, Reveals the Evolutionary Specialization of Diatoms from Phago-Mixotrophs to Photoautotrophs, Commun. Biol., 6, 697 (2023).
Kaneko H.; Endo H.; Henry H.; Berney C.; Mahé F.; Poulain J.; Labadie K.; Beluche O.; El Hourany R.; Tara Oceans Coordinators, Chaffron S.;
Wincker P.; Nakamura R.; Karp-Boss L.; Boss E.; Bowler C.; de Vargas C.; Tomii K.; Ogata H., Predicting Global Distributions of Eukaryotic
Plankton Communities from Satellite Data, ISME Commun., 3, 101 (2023).
Meng L.; Delmont T. O.; Gaïa M.; Pelletier E.; Fernandez-Guerra A.; Chaffron S.; Neches R. Y.; Wu J.; Kaneko H.; Endo H.; Ogata H., Genomic
Adaptation of Giant Viruses in Polar Oceans, Nat. Commun., 14, 6233 (2023).
58

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Isolation and Whole Genome Sequencing of
Giant Viruses from Lake Biwa, Japan
Giant viruses are double-stranded DNA viruses withextremely large genomes and particles reaching 2.5
megabases and 1.5 µm, respectively. These viruses are
ubiquitous in the environment and important drivers fornutrient cycles. Currently, various giant viruses have been
isolated, but whole-genome sequences of these viruses arelimited because of sequencing costs. Here, we evaluatedaccuracy of giant virus genome assembly by MinION
sequencing, which enables rapid and low-cost sequencing.
As MinION sequencing produces error-prone reads, theassembly process generally requires correction by othersequencing platforms. However, recent studies assembled
high-quality microbial genomes by MinION sequencing
alone. We confirmed that genome assembly constructedby MinION sequencing alone is highly accurate for giant
viruses with over 99.98% identity to the reference genome
by re-sequencing a prototype giant virus. As a proof ofconcept, we further sequenced five giant viruses isolated
from Lake biwa, Japan, by using MinION sequencing.
Comparison between newly assembled genomes and reference genomes revealed that these isolates represent new
species of marseillevirus, pithovirus, and mimivirus. Overall,
we propose that genome assembly by MinION sequencing
alone is an effective approach for a genome-wide analysis
of isolated giant viruses. This research was published in ajournal, Environmental microbiology (doi: 10.1111/14622920.16476).

Figure 1. Isolated giant viruses observed under transmission electron
microscopy. Names of isolates were shown top left. BNT8A and BSD11G
are marseilleviruses. BST12E is a pithovirus. BST10G and BN60m3A
are mimiviruses. Bars indicate 500 nm. This figure is modified from thatpublished in Hikida et al. (2023) Environ. Microbiol. under the CC BY 4.0
license.

A Giant Endogenous Viral Element:
Evidence of Recent Infection of a DoubleStranded DNA Virus in a Fungus
Fungal virosphere is dominated by RNA viruses, with few
single-stranded DNA viruses. So far, no double-stranded
DNA virus has been identified in fungi. Rhizophagus
irregularis is a species of arbuscular mycorrhizal fungus,
belonging to the class Glomeromycetes. We searched viralsignals within chromosome-level genomic assemblies offive different strains of this fungi species. On chromosome
8 of a strain 4401, we discovered a 1.5-megabase region,
which showed distinct features from other chromosomal
regions with strong viral signals. This viral region harbors
five Nucleocytoviricota marker genes. Our phylogenetic
analysis revealed that these genes are closely related to
Asfarviridae sequences (Fig. 1). These marker genes remain
in single copy and show the same tree topology, whichsuggest that this viral region originated from a single viral
integration event. In the chromosomes of other strains,
this viral region is absent. Also, the content of repetitive
sequences and transposable elements in this viral region islower compared to other genomic regions. These findings
suggest that the viral region was inserted after the divergence of five R. irregularis strains. This work has been
published in Zhao et al., Virus Evolution, 2023, doi: 10.1093/
ve/vead064.

Figure 2. Phylogenetic trees based on core genes of viruses of the phylum
Nucleocytoviricota based on maximum-likelihood frameworks. Blue circles represent supports that passed confidence cutoff for branches. Yellow
represents asfarviruses, and red indicates sequences from the viral region.
(a) Concatenated tree of three polymerases. (b) Tree of mRNA capping
enzyme (c) Tree of viral late transcription factor 3.

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Bioinformatics Center– Mathematical Bioinformatics –https://www.bic.kyoto-u.ac.jp/takutsu/index.html

Program-Specific Res
LI, Ruiming (Ph D)ProfAKUTSU, Tatsuya(D Eng)

Assoc ProfTAMURA, Takeyuki(D Inf)Assist Prof
MORI, Tomoya(D Inf)

Guest Res Assoc*
SUN, Liangjie(Ph D)*JSPS Postdoctoral
Fellowships for Research inJapan, China, 1 November
2023–31 October 2025

Students
TAKAGI, Motoshige (D3)OHTOMO, Masahiro (D3)NAKASHIMA, Shogo (D3)

MU, Lixuan (D3)SHIOTA, Koji (D3)
LIU, Chunting (D3)

MA, Yier (D2)
FUJITA, Satoki (D2)GHAFOOR, Mamoona (D2)

CUI, Yan (M2)
IWAKI, Takuma (M1)
WU, Chenyao (D1)

Guest Res Assoc
ZHAO, Jiaying
LI, Wei
HAN, Mingjing
ZHONG, Yezhao
HSU, Zi-Chu
CHEN, Tze-Shin
TUNG, Cheng-Yu

The University of Hong Kong, Hong Kong, 31 May 2023–21 August 2023
Nankai University, China, 22 August 2023–31 May 2024
Nankai University, China, 22 August 2023–31 May 2024
National University of Ireland, Galway, Ireland, 6 November 2023–26 January 2024
National Yan Ming Chiao Tung University, Taiwan, 25 November 2023–15 December 2023
National Yan Ming Chiao Tung University, Taiwan, 25 November 2023–15 December 2023
National Yan Ming Chiao Tung University, Taiwan, 25 November 2023–15 December 2023

Scope of Research
Due to the rapid progress of genome sequencing technology, whole genome sequences of organisms ranging frombacteria to human have become available. In order to understand the meaning behind the genetic code, we have beendeveloping algorithms and software tools for analyzing biological data based on advanced information technologies suchas theory of algorithms, artificial intelligence, and machine learning. We are currently studying the following topics: sys­
tems biology, scale-free networks, protein structure prediction, the inference of biological networks, chemo-informatics,
and discrete and stochastic methods for bioinformatics.

KEYWORDS
Complex Networks
Boolean Networks
Neural Networks
Chemical Graphs
Protein Informatics

Recent Selected Publications
Melkman, A. A.; Guo, S.; Ching, W-K.; Liu, P.; Akutsu, T., On the Compressive Power of Boolean Threshold Autoencoders, IEEE Transactions
on Neural Networks and Learning Systems, 34, 921-931 (2023).
Matsuda, K.; Shirakami, A.; Nakajima, R.; Akutsu, T.; Shimono, M., Whole-Brain Evaluation of Cortical Microconnectomes, eNeuro, 10,
ENEURO.0094-23.2023 (2023).
Mori, T.; Takase, T.; Lan, K-C.; Yamane, J.; Alev, C.; Kimura, A.; Osafune, K.; Yamashita, J. K.; Tatsuya, A.; Kitano, H.; Fujibuchi, W.,
eSPRESSO: Topological Clustering of Single-Cell Transcriptomics Data to Reveal Informative Genes for Spatio-Temporal Architectures ofCells, BMC Bioinformatics, 24, 252 (2023).
Cao, Y.; Pi, W.; Lin, C-Y.; Münzner, U.; Ohtomo, M.; Akutsu, T., Common Attractors in Multiple Boolean Networks, IEEE ACM Transactions
on Computational Biology and Bioinformatics, 20, 2862-2873 (2023).
Tamura, T., Trimming Gene Deletion Strategies for Growth-Coupled Production in Constraint-Based Metabolic Networks: TrimGdel, IEEE
ACM Transactions on Computational Biology and Bioinformatics, 20, 1540-1549 (2023).
60

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
On the Compressive Power of Autoencoders
Using Linear Threshold Activation Functions
Artificial neural networks have recently been extensively
applied to bioinformatics. Among various models of artificial neural networks, autoencoders attract much attention
because of their power to generate new objects such asprotein sequences and chemical structures. An autoencoder
is a layered neural network (Figure 1) consisting of an encoder which compresses an input vector to a lower dimensional vector, and a decoder which transforms the lowdimensional vector back to the original input vector (or one
that is very similar). Although it is often mentioned that
autoencoders perform dimensionality reduction, a kind ofdata compression, how data are compressed is not yet veryclear. Therefore, we study the numbers of nodes and layersthat are required to ensure that each vector in a given setof distinct input binary vectors is transformed back to its
original using a autoencoder model with linear threshold
activation functions. We show that for any set of distinct
vectors there exists a seven-layer autoencoder with the
optimal compression ratio, but that there is a set of vectors
for which there is no three-layer autoencoder with a middle
layer of the same size. We also study the numbers of nodes
and layers required only for encoding, and the results
suggest that decoding is more difficult than encoding.

Trimming Gene Deletion Strategies for
Growth-Coupled Production in ConstraintBased Metabolic Networks: TrimGdel
When simulating genome-scale metabolite production
using constraint-based metabolic networks, it is often necessary to find gene deletion strategies which lead to
growth-coupled production, which means that target metabolites are produced when cell growth is maximized. Oneof the best current methods for this problem is the minimal
cut set-based method, which utilizes the fact that minimal
cut sets in the primal network are the elementary modes in
the corresponding dual network. This method is effective
when the number of gene deletions is relatively small, butwhen the number of required gene deletions exceeds 20,
the time required for the calculation is often unfeasible.
Therefore, a complementing algorithm that is effective
even when the required number of gene deletions is approximately 20 to 40 would be helpful because the numberof genes that can be deleted in a strain is increasing withadvances in genetic engineering technology. In this study,
the present author developed an algorithm, TrimGdel,
which first computes a strategy with many gene deletions
that results in growth-coupled production and then gradually reduces the number of gene deletions while maintaining the production rate and growth rate. The results of thecomputer experiments showed that, for 34.2% of the target
metabolites in iML1515, the genome-scale constraint-basedmodel of Escherichia coli, TrimGel could calculate genedeletion strategies of size 40 or less (23.6% for between 21
and 40) leading to growth-coupled production. TrimGdel
can calculate stoichiometrically feasible gene deletion
strategies, especially of sizes 21 to 40, which lead to
growth-coupled production of target metabolites, which
include useful vitamins such as biotin and pantothenate, forwhich existing methods could not.
The developed software is available on https://github.
com/MetNetComp/TrimGdel

Figure 1. Architecture of an autoencoder.

Figure 2. Each gene deletion strategy is evaluated by the least value of thetarget metabolite production rate when maximizing the cell growth rate.

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Bioinformatics Center– Bio-knowledge Engineering –https://www.bic.kyoto-u.ac.jp/pathway/index.html

Prof
Senior Lect
Program-Specific Res Distinguished Visiting Senior Lect
MAMITSUKA, Hiroshi NGUYEN, Hao Canh NGUYEN, Anh Duc PETSCHNER, Peter(D Sc)(D Knowledge Science)(D Pharm Sc)(Ph D)

Students
JIANG, Zhiqian (RS)OTAGIRI, Yuan (UG)

Guest Res Assoc
LI, Yufei

Xi’an Jiaotong University, China, 2 May 2022–23 April 2023

Scope of Research
We are interested in graphs and networks in biology,
chemistry, and medical sciences, including metabolic
networks, protein-protein interactions and chemicalcompounds. We have developed original techniques inmachine learning and data mining for analyzing thesegraphs and ­networks, occasionally combining withtable-­format datasets, such as gene expression andchemical properties. We have applied the techniquesdeveloped to real data to demonstrate the performanceof the methods and find new scientific i­nsights.

KEYWORDS
Bioinformatics
Data Mining

Machine Learning
Artificial Intelligence

Systems Biology

Recent Selected Publications
Wang, X.; Sun, L.; Nguyen, C. H.; Mamitsuka. H., Multiplicative Sparse Tensor Factorization for Multi-View Multi-Task Learning, Proceedingsof the 26th European Conference on Artificial Intelligence (ECAI 2023), 2560-2567 (2023).
Nguyen, D. A.; Nguyen, C. H.; Petschner, P.; Mamitsuka, H., SPARSE: A Sparse Hypergraph Neural Network for Learning Multiple Types ofLatent Combinations to Accurately Predict Drug-drug Interactions, Bioinformatics (Proceedings of the 30th International Conference onIntelligent Systems for Molecular Biology (ISMB 2022)), 38 (Supplement 1), i333-i341 (2022).
You, R.; Qu, W.; Mamitsuka, H.; Zhu, S., DeepMHCII: A Novel Binding Core-Aware Deep Interaction Model for Accurate MHC II-peptide
Binding Affinity Prediction, Bioinformatics (Proceedings of the 30th International Conference on Intelligent Systems for Molecular Biology(ISMB 2022)), 38 (Supplement 1), i220-i228 (2022).
Nguyen, C. H.; Mamitsuka, H., Learning on Hypergraphs with Sparsity, IEEE Transactions on Pattern Analysis and Machine Intelligence,
43(8), 2710-2722 (2021).
Nguyen, D. H.; Nguyen, C. H.; Mamitsuka, H., ADAPTIVE: leArning DAta-dePendenT, concIse molecular VEctors for fast, Accurate Metabolite
Identification from Tandem Mass Spectra, Bioinformatics (Proceedings of the 27th International Conference on Intelligent Systems for
Molecular Biology (ISMB/ECCB 2019)), 35(14), i164-i172 (2019).

62

TOPICS AND INTRODUCTORY COLUMNS OF LABORATORIESTopics
Data Integrative Machine Learning: DIVERSE,An Example Approach to Personalized Medicine.
Multiple datasets can be found in any applications. For example,
the main E-commerce data is a matrix of individuals (users) anditems. Additionally, matrices on user demographic data and item
contents can be obtained. In this case, the three matrices can begiven, sharing the two dimensions, i.e. those of users and of
items. Our focus is personalized medicine, where the main data isa matrix of individuals (patients, eventually cell lines) and theirdrug responses. The problem to be addressed is the drug response
prediction, i.e. to predict unknown effective drugs for patients(cell lines). For this purpose, additional datasets can be used, suchas a drug similarity matrix, drug-target interactions (a target is a
protein, which is equivalent to the corresponding gene). These
relevant data sources are called omics data, particularly in biology.
Fig. 1 shows a schematic picture of omics data in drug response
prediction, consisting of five matrices, including the main matrix
R of drugs vs. cell lines.

each dataset is incorporated into the matrix factorization framework of DIVERSE sequentially,

Figure 2. Overview of our systematic framework, DIVERSE, of integrating multiple data sets: importance weight tri-(or bi-)matrix factorization.
We start with adding D to R (first row: DIVERSE3-D). We then add P
to DIVERSE3-D (second row: DIVERSE3-P). Similarly, we add G to
DIVERSE3-P (third row: DIVERSE3-G) and T to DIVERSE3-G (fourthrow: DIVERSE3-T). Another option of the last addition is bi-matrix
factorization, and this is the last row: DIVERSE2-T.

We empirically validated the performance of DIVERSE, comparing with five other methods, including three state-of-the-art
methods, under 5x5-fold cross-validation. Experimental results
indicate that DIVERSE significantly outperformed all comparedmethods in both mean-squared error (MSE) and Spearman correlation coefficient (Sc), particularly for out-of-matrix prediction,
which is a real-world setting and much harder than in-matrix
prediction. Results clearly show the performance advantage of
DIVERSE over the current methods for predicting drug responses.
Table 1 shows one typical example of the results, where ten
methods are compared.

Figure 1. Conceptual integration configuration of the multiple data fromthree types of entities; d, g and c denote drugs, genes and cell lines,
respectively.

Although large-scale omics data have been generated for drug
response prediction, many machine learning methods have failed
to achieve good performance for multiple heterogeneous data
sources, because these methods have been designed for only asingle type of data. Thus, a challenging task is to build precise
prediction models on diverse data, coming from different sources,
which are difficult to compare. In fact, data integration has toovercome several obvious problems, such as different data sizes,
complexity, and noisiness. However, more importantly, dataintegrative machine learning methods need to decide which information is useful to be incorporated and how significant the
information is for the prediction task. This is the most criticalproblem to be addressed for machine learning models with diverse multi-omics data. For this problem, we propose DIVERSE,
a framework to efficiently integrate scientifically diverse data,
i.e. genomic, chemical and molecular interaction information.
DIVERSE has two unique features: 1) It is methodologically
flexible. Most existing studies ignore uncertainty, and hencecannot accept missing values.to predict missing drug responses ofcancer cell lines. 2) It allows to compute importance weights overgiven multiple matrices, showing the contribution of the given
matrices to prediction. DIVERSE solves these two practicallyimportant problems by using a Bayesian setting of matrix factorization. Fig. 2 shows the systematic framework of DIVERSE forthe given matrix combination, shown in Fig. 1. In this framework,

Table 1. MSE and Sc (average scores of 5x5 cross-validation) of ten
compared methods in out-of-matrix prediction.

Furthermore, the results indicate that the MSE and Sc of
DIVERSE were smoothly improved by the step-wise addition ofeach data set. Table 2 shows the performances of different data
integration types of DIVERSE for three different cancer cell line
datasets.

Table 2. Average MSE and Spearman correlation scores over 5x5-foldcross-validation for three different types of cancer cell lines.

Finally, these advantages of DIVERSE were confirmed byseveral case studies. Overall, DIVERSE is useful for performing
integrative machine learning for given multiple omics data sources,
which has not been handled by a regular machine learning algorithm.

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63

HAKUBI RESEARCHERS’ACTIVITIES IN ICR
Hakubi Project: Fosterage and Support ofYoung Researchers, Kyoto University

Research Topic

Optoelectronic Energy Recycling and Quantum Cooperative
Effects in Semiconductor Nanostructures
Host Laboratory Laboratory of Nanophotonics
Host Professor KANEMITSU, Yoshihiko

Program-Specific Assoc ProfTAHARA, Hirokazu(D Sc)

Outline of Research
Semiconductor nanostructures are attractive materials that provide a platform to enhance quantum effects. In nanomaterials, strongly-confined electrons and holes form unique quantum states such as multiexcitons, which are hardly generated in bulk semiconductors. Since multiexcitons consist of a few electrons and holes, their generation and dissociation
processes have a great potential to increase electric signals in photon-to-current conversion. My research focuses onapplications of quantum effects and control of photon-to-current conversion processes in semiconductor nanostructures. I
will clarify the microscopic mechanism of photocarrier generation processes in coupled nanostructures and establish a
way to recycle thermal and radiative energies.

66

HAKUBI RESEARCHERS’ ACTIVITIES IN ICRACTIVITIES OF
INTERNATIONAL JOINT
USAGE/RESEARCHCENTER

iJURC Cooperative Research Subjects 2023
(1 April 2023 ~ 31 March 2024)
STARTING-UP SUBJECTS(IN SPECIFIC FIELDS CHOSEN BY iJURC)Radiolysis of Concentrated Native Proteins by Accelerated
Electrons
RAFFY, Quentin, Institut Plurisdisciplinaire Hubert Curien (IPHC)
Host in iJURC OGAWARA, RyoI
Development of New Nano-Structure Target for ISOLOHNISHI, Tetsuya, Nishina Center for Accelerator-Based Science,
RIKEN
Host in iJURC WAKASUGI, Masanori
High-Pressure synthesis and Li Conducting Study of Li-Al-Cl
Compounds as Solid Electrolytes in Batteries
KOEDTRUAD, Anucha, Chinese Academy of Science (CAS),
Institute of High Energy Physics (IHEP), Chinese Spallation
Neutron Source (CSNS)
Host in iJURC SHIMAKAWA, Yuichi
I
Crystal Structures and Oxygen Conduction Properties Researchof Metal Oxides at High Temperature
GUO, Haichuan, China Spallation Neutron Source Science Center(CSNS), Institute of High Energy Physics, Chinese Academy of
Sciences
Host in iJURC SHIMAKAWA, Yuichi
I
Development of Transformation of Lignin–Based Aromatic
Building Blocks Using Organocatalyst
HASHIMOTO, Toru, Department of Applied Chemistry, Facultyof Engineering, Sanyo-Onoda City University
Host in iJURC NAKAMURA, Masaharu
I

Development of Highly Active Metal Cluster Catalysts by Using
Electron Transfer Network
KONDO, Mio, Division of Applied Chemistry, Graduate Schoolof Engineering, Osaka University
Host in iJURC TANIFUJI, Kazuki
F
Modulated Luminescence of Coordination Complex under Vibrational Strong Coupling
HIRAI, Kenji, Research Institute for Electronic Science Hokkaido
University
Host in iJURC KANEMITSU, YoshihikoSpectroscopic Study of Dot-in-Crystal Perovskites toward
Semiconductor Optical Refrigeration
YAMADA, Yasuhiro, Granduate School of Science, Chiba University
Host in iJURC KANEMITSU, Yoshihiko
Quantum Properties of Lead Perovskite Solar Cells by TwoDimensional Optical Fourier Transform Spectroscopy
OGAWA, Yoshihiro, Joetsu University of Education
Host in iJURC KANEMITSU, Yoshihiko
Terahertz Laser by Topological Edge States in Non-Hermitian
Systems
OBUSE, Hideaki, Faculty of Engineering, Hokkaido University
Host in iJURC HIRORI, Hideki
Controlling Hydrogen Spillover on Oxides
HOSOKAWA, Saburo, Faculty of Materials Science and Engineering, Kyoto Institute of Technology
Host in iJURC KAN, Daisuke

Synthesis of Phosphine-Protected Iron Clusters to Study Their
Magnetic Properties
SHIGA, Takuya, Department of Chemistry, Institute of Pure andApplied Sciences, University of Tsukuba
Host in iJURC HIGAKI, Tatsuya

Development of Defective Nickel Oxide Catalysts for Highly
Selective Functionalization
TAKETOSHI, Ayako, Faculty of Engeneering, Yokohama National
University
Host in iJURC NAKAMURA, Masaharu
F

Catalytic Activation of Silicon-Oxygen Bond via Nucleophilic
Activation of Silane
KAMEO, Hajime, Department of Chemistry, Graduate School of
Science, Osaka Metropolitan University
Host in iJURC OHKI, Yasuhiro

Efficient Synthesis and Physical Properties of π-Extended
Molecules Bearing Difluoroboryl or Sulfonyl Groups
MITSUDO, Koichi, Graduate School of Natural Science andTechnology, Okayama University
Host in iJURC WAKAMIYA, Atsushi

Asymmetric Synthesis of Planar-Chiral Metallocenes by Plane-toPlane Chirality Transfer
OGASAWARA, Masamichi, Department of Natural Science,
Graduate School of Science and Technology, and Research
Cluster on “Functional Material Development for Agro-/Medo-/
Pharmachemicals”, and Tokushima International Science Institute,
Tokushima University
Host in iJURC OHKI, Yasuhiro

A Study on Statistical Machine Learning for Efficient Graph
Structured Data Analysis
KARASUYAMA, Masayuki, Department of Computer Science,
Nagoya Institute of Technology
Host in iJURC MAMITSUKA, Hiroshi
I

Carbon Fixation Catalysts Composed of Well-Defined Cu-Hydride
Complexes and Functionalized Organosilica
NAKAJIMA, Takayuki, Department of Chemistry, Faculty of
Science, Nara Women’s University
Host in iJURC OHKI, Yasuhiro

Evaluation of Prediction with MetNetComp Using Tensor
Decomposition Based Unsupervised Feature Extraction
TAGUCHI, Yoshihiro, Faculty of Science and Engineering, Chou
University
Host in iJURC TAMURA, Takeyuki
Control and Analysis of Complex Networks via Probabilistic
Minimum Dominating Sets
NACHER, Jose, Department of Information Science, Faculty of
Science, Toho University
Host in iJURC AKUTSU, Tatsuya

I : International Joint Research
F : Female PI
68

ACTIVITIES OF INTERNATIONAL JOINT USAGE/RESEARCH CENTERElucidation of Host-Giant Virus Interaction Using Transcriptomics
of Giant Virus-Infected Acanthamoeba Cells
TAKEMURA, Masaharu, Institute of Arts and Sciences, Kagurazaka
Division, Tokyo University of Science
Host in iJURC OGATA, Hiroyuki

Characterization of Molecular Orientation during Wear of Fluoropolymer
KASUYA, Motohiro, Faculty of Production Systems Engineeringand Sciences, Komatsu University
Host in iJURC HASEGAWA, Takeshi

Development of a Viral Genome Information Infrastructure for
Elucidation of Viral Dark Matter
NISHIMURA, Yosuke, JAMSTEC, Japan Agency for MarineEarth Acience and Technology, Research Center for Bioscienceand Nanoscience
Host in iJURC OGATA, Hiroyuki

Identification of Active Gibberellins in the Basal Land Plant
Marchantia polymorpha
KOHCHI, Takayuki, Graduate School of Biostudies, Kyoto University
Host in iJURC YAMAGUCHI, Shinjiro

Combining Tellurium Mediated Radical Polymerization andMulticomponent Polymerization towards Unique Stimuli
Responsive Polypeptoids/poly(N-vinyl amide)s Copolymers
DEBUIGNE, Antoine, Chemistry Department, Center for Education
and Research on Macromolecules, University of Liege, Belgium
Host in iJURC YAMAGO, Shigeru
I
Studies of Geometric and Electronic Structure/Reactivity Correlation in Cofacial Metalloporphyrin Dimers
OHTA, Takehiro, Department of Applied Chemistry, Faculty ofEngineering, Sanyo-Onoda City University
Host in iJURC OHKI, Yasuhiro
Synthesis of Self-Assembled Azulene Derivatives Utilizing Boron,
and Creation of New Reactions and Functions
WAKABAYASHI, Shigeharu, Department of Clinical Nutrition,
Faculty of Health Science, Suzuka University of Medical Science
Host in iJURC OHKI, Yasuhiro
Controlling of Secondary Structure in Polysiloxane Main Chain
and Application for Chiral Silica
HIRAI, Tomoyasu, Department of Applied Chemistry, Osaka
Institute of Technology
Host in iJURC TAKENAKA, Mikihito
Exploration of Novel Optical Phenomena in Semiconductors
with High Quantum Efficiency of Radiation
KOJIMA, Kazunobu, Graduate School of Engineering, Osaka
University
Host in iJURC KANEMITSU, Yoshihiko
Stoichiometry of Bioactive Trace Metals in the Osaka Bay and Its
Inflowing River Waters
NAKAGUCHI, Yuzuru, Faculty of Science and Engineering,
Kindai University
Host in iJURC SOHRIN, Yoshiki
Study on High Selective Membrane Separation of Metal Ions by
Use of Polimer Inclusion Membranes of Ionic Liquid Containing
the Metal Complexes
MUKAI, Hiroshi, Faculty of Education, Kyoto University of
Education
Host in iJURC SOHRIN, Yoshiki
Fabrication and Characterization of Luminescent Thin Films ofLanthanide Complexes for Solid-State Ion Sensors
MIEDA, Eiko, Department of Chemistry, Graduate School of
Science, Osaka Metropolitan University
Host in iJURC HASEGAWA, Takeshi
FPhysicochemical Characterization of Novel Hybrid Partially
Fluorinated Phospholipid Bilayers
SONOYAMA, Masashi, Faculty of Science and Technology,
Gunma University
Host in iJURC HASEGAWA, Takeshi

Preparation and Precise Characterization of Model TwoDimensional Sheet-Shaped Polymers
DOI, Yuya, Department of Materials Physics, Nagoya University
Host in iJURC SATO, Takeshi
Spin Signals in a Ferrimagnetic Film near the Compensation
Temperature
HIROHATA, Atsufumi, Nagoya University, Department ofMaterials Physics
Host in iJURC ONO, Teruo
IStudy on the Spin Injection Using Perpendicularly Magnetized
Ferromagnetic Conductor Film
TANAKA, Masaaki, Nagoya Institute of Technology
Host in iJURC ONO, Teruo
Demonstration of Topological Phase Control in Chalcogenide
Superlattices
MOROTA, Misako, National Institute of Advanced Industrial
Science and Technology (AIST)
Host in iJURC ONO, Teruo
F
EXPANDING SUBJECTS(IN SPECIFIC FIELDS CHOSEN BY iJURC)
Development of Energy Sensitive Muon Spin Rotation (muSR)
Spectrometer
MA, Yue, Meson Science Laboratory, RIKEN
Host in iJURC TSUKADA, Kyo
On the Mechanism of the CO2 Reduction Catalyzed by Cubic[Mo3S4Pd] Clusters: a Computational StudySAMEERA, W. M. C., Department of Chemistry, University ofColombo
Host in iJURC OHKI, Yasuhiro
I
Development and Device Evaluation of New D-A Emitters Basedon Rigidified Planar Triarylborone Acceptors
MARDER, Todd B., Institut für Anorganische Chemie, JuliusMaximilians-Universität Würzburg
Host in iJURC KAJI, Hironori
I
Design and Tailoring Advanced Functional Materials: Symmetry
Operation and High Pressure Synthesis
CHEN, Wei-Tin, Center for Condensed Matter Sciences, National
Taiwan University
Host in iJURC SHIMAKAWA, Yuichi
I
High-Performance Materials for Energy Storage Electrochemical
Devices
GARCIA MARTIN, Susana, Departamento de Química Inorgánica,
Facultad de Ciencias Químicas, Universidad Complutense
Host in iJURC SHIMAKAWA, Yuichi
I F

ICR ANNUAL REPORT, 2023

69

Photocatalytic C-H Bond Functionalization
ALAKANANDA, Hajra, Department of Chemistry, Visva-Bharati
University
Host in iJURC NAKAMURA, Masaharu
I
Development of Unsymmetrical π-Electron Systems of Heavier
Main Group Elements and Elucidation of Their Property
IWAMOTO, Takeaki, Department of Chemistry, Graduate Schoolof Science, Tohoku University
Host in iJURC MIZUHATA, Yoshiyuki
I
Creation of Effective Oxidation Scavenger for Efficient PerovskiteBased Solar Cells
SASAMORI, Takahiro, Department of Chemistry, Faculty ofPure and Applied Sciences, University of Tsukuba
Host in iJURC WAKAMIYA, Atsushi
I
A Caging Strategy for Cholinergic Optopharmacology
ARAI, Satoshi, NanoLSI, Kanazawa University
Host in iJURC OHMIYA, Hirohisa
Development and Evaluation of THz-STM for Low-Temperatureand High Magnetic Field
TACHIZAKI, Takehiro, School of Information Science andTechnology, Tokai University
Host in iJURC KANEMITSU, Yoshihiko
Regioselective C-H Activation Enabled by Substrate Recognition
ILIES, Laurean, Center for Sustainable Resource Science, RIKEN
Host in iJURC NAKAMURA, Masaharu
Development of Co-Facial-Type Dinuclear Complexes
YAMAGUCHI, Yoshitaka, Faculty of Engeneering, Yokohama
National University
Host in iJURC NAKAMURA, Masaharu
Developing Machine Learning Approaches for Prediction ofProtein Stability Changes upon Missense Mutations
SONG, Jiangning, Biomedicine Discovery Institute, Monash
University
Host in iJURC AKUTSU, Tatsuya
I
Integrating Omics Data and Module-Based Network with Deep
Learning to Develop Cancer Type Predictive Models
YANG, Jinn-Moon, Department of Biological Science andTechnology, Institute of Bioinformatics & Systems Biology,
National Yang Ming Chiao Tung University
Host in iJURC AKUTSU, Tatsuya
I
Ecology and Evolution of Large and Giant DNA Viruses
DELMONT, Tom O., CNRS/Genoscope/UMR8030
Host in iJURC OGATA, Hiroyuki

I

Application of Metagenomics and a Temperature-Driven Mathematical Model to Estimate the Global Distribution of Micromonas
Viruses
DEMORY, David, CNRS, UMR723
Host in iJURC ENDO, Hisashi
I
Effective Biomolecular Analysis and Application to Medical andAgricultural Research
KAYANO, Mitsunori, Research Center for Global Agromedicine,
Obihiro University of Agriculture and Veterinary Medicine
Host in iJURC MAMITSUKA, Hiroshi

Investigations into Cofactor Biosynthesis of N2-Reducing Enzyme
via Semi-Synthetic Approach
RIBBE, Markus W., Chancellor’s professor at Department of
Molecular Biology and Biochemistry, Department of Chemistry,
University of California, Irvine
Host in iJURC TANIFUJI, Kazuki
I
Radical-Polar Crossover Catalysis for Synthesis of Complex
Natural Products
HAN, Sunkyu, Department of Chemistry, KAIST
Host in iJURC OHMIYA, Hirohisa
I
Development of Multi-Resonant TADF Emitters with Short
Delayed Lifetimes and Their Use in Long Lifetime OLEDs
ZYSMAN-COLMAN, Eli, Organic Semiconductor Centre,
EaStCHEM School of Chemistry, University of St Andrews
Host in iJURC KAJI, Hironori
I
Design and Synthesis of Linear Molecules for Improving Outcoupling Efficiency of Solution-Possessed OLEDs
RAJAMALLI, Pachaiyappan, Materials Research Centre, Indian
Institute of Science, Bangalore
Host in iJURC KAJI, Hironori
I
Precise Synthesis and Controlling Higher Order Structure of
Tadpole-Like Janus Cellulose Nanocrystal
GOTO, Atsushi, School of Physical & Mathematical Sciences Division of Chemistry & Biological Chemistry Nanyang Technological University
Host in iJURC KINOSE, Yuji
I
Development of Lead Free Metal Halide Perovskite
TACHIBANA, Yasuhiro, School of Engineering, PMT University
Host in iJURC TERANISHI, Toshiharu
I
Synthesis of Graphene Nanoribbons Containing Non-Hexagonal
Rings
CHAOLUMEN, College of Chemistry and Chemical Engineering,
Inner Mongolia University (IMU)
Host in iJURC HASHIKAWA, Yoshifumi
I
Optoelectronic Materials with Open-Cage C60 Derivatives as
Building Blocks
ZHANG, Sheng, Engineering Research Center for Nanomaterials(ERCN), Henan University
Host in iJURC MURATA, Yasujiro
I
The Reactivity of Guanidino-Isatins in Prato Cycloaddition Reaction
MARGETIC, Davor, Laboratory for physical organic chemistry,
Division of organic chemistry and biochemistry, Rudjer Boskovic
Institute
Host in iJURC MURATA, Yasujiro
I
Development of Functional Molecule for Efficient Perovskite
Solar Cells
SAEKI, Akinori, Department of Applied Chemistry, Graduate
School of Engineering, Osaka University
Host in iJURC WAKAMIYA, Atsushi
I
Electrochemical and Photochemical Degradation Reaction
INAGI, Shinsuke, School of Materials and Chemical Technology,
Tokyo Institute of Technology
Host in iJURC OHMIYA, Hirohisa
Light-Driven Organosulfur Catalysis for Sugar Modification
HIRAI, Go, Graduate School of Pharmaceutical Sciences, Kyushu
University
Host in iJURC OHMIYA, Hirohisa

70

ACTIVITIES OF INTERNATIONAL JOINT USAGE/RESEARCH CENTER

Synthesis of Polymers Having Carbazolophane Moiety and Their
Application of Hole Transport and CPL Materials
TANI, Keita, Osaka Kyoiku University
Host in iJURC TSUJII, Yoshinobu
Elucidation of Design Principles of Covalent Organic Solid
SolutionsSUZUKI, Mitsuharu, Graduate School of Engineering, Osaka
University
Host in iJURC MURATA, Yasujiro
Synthesis and Properties of Emissive Triplet Diradicals
SHIMIZU, Akihiro, Graduate School of Engineering Science,
Osaka University
Host in iJURC HIROSE, Takashi
Polymerization of Functional Vinyltellurides Prepared by Flow
Reactors
NAGAKI, Aiichiro, Faculty of Science, Hokkaido University
Host in iJURC YAMAGO, Shigeru
Study on Dependence of Electron Delocalization on Charged,
Spin and Excited States in Conjugated Macrocycles
KISHI, Ryohei, Graduate School of Engineering Science, Osaka
University
Host in iJURC KAYAHARA, Eiichi
A Study on Radicals in Macrocyclic Systems: SOMO-HOMO
Energy Conversion
ABE, Manabu, Graduate School of Advanced Science andEngineering, Hiroshima University
Host in iJURC KAYAHARA, Eiichi
Synthesis and Functionally Development of Donor-Acceptor
Cycloparaphenylene Derivatives through Reorganization ofMacrocyclic Gold Complexes via Dynamic Gold-Carbon Bonds
TSUCHIDO, Yoshitaka, Faculty of Science Division I, Tokyo
University of Science
Host in iJURC KAYAHARA, Eiichi
Trace Metal Elemental and Isotopic Composition in the North
Pacific Ocean: Sources and Internal Cycling (4)HO, Tung-Yuan, Research Center for Environmental Changes,
Academia Sinica
Host in iJURC SOHRIN, Yoshiki
I
Resolving the Structure-Dynamics-Property Relationship in
Polymer Nanocomposites under Uniaxial Stretching-III
KOGA, Tadanori, Department of Material Science and Chemical
Engineering, Stony Brook University
Host in iJURC TAKENAKA, Mikihito
IHigh Frequency Response of Polymeric Liquids: Rheology andDielectric Relaxation
SUKUMARAN, Sathish K., Graduate School of Organic Materials
Science, Yamagata University
Host in iJURC SATO, Takeshi
I
Ultrafast Exciton Dynamics in Thermally Activated Delayed
Fluorescence Molecular Aggregates with Heterogeneous Conformational Distribution
SOTOME, Hikaru, Division of Frontier Materials Science andCenter for Promotion of Advanced Interdisciplinary Research,
Graduate School of Engineering Science, Osaka University
Host in iJURC KAJI, Hironori
Construction of Theoretical Guidelines for Designing Plasmonic
Nanoalloys
IIDA, Kenji, School of Engineering, PMT University
Host in iJURC TERANISHI, Toshiharu

Characterization of Quantum Magnon Using Hybrid Magnonic
Systems
KIM, Kab-Jin, Department of Physics, Korea Advanced Instituteof Science and Technology
Host in iJURC ONO, Teruo
I
Non-Reciprocity of Spin Wave Propagation Generated by OrbitalHall Effect in Transition Metal Dichalcogenides
KIM, Sanghoon, Department of Physics, University of Ulsan
Host in iJURC ONO, Teruo
I
Research Toward Stable NV Centers at Shallow Region and Spin
Dynamics in Diamond
BALASUBRAMANIAN, Gopalakrishnan, Helmholtz-Zentrum
Dresden-Rossendorf (HZDR), Germany
Host in iJURC MIZUOCHI, Norikazu
I
Research on the Efficiency Enhancement of the NV Centers
Creation in Nanodiamond
SEGAWA, Takuya F, Laboratory for Physical Chemistry, ETH
ZürichHost in iJURC MIZUOCHI, Norikazu
I
Research toward High Sensitive NV Quantum Sensor in Diamond
WRACHTRUP, Jörg, Stuttgart University
Host in iJURC MIZUOCHI, Norikazu
I
Development of Fe-Based D03 Type Alloys and Its Thermoelectric
Property
NAGAHAMA, Taro, Hokkaido Univerisity
Host in iJURC ONO, Teruo
Research of Surface State for Diamond Quantum Sensor
TOKUDA, Norio, NanoMaterials Research Institute, KANAZAWA
UNIVERSITY
Host in iJURC MIZUOCHI, Norikazu
Research of Quantum Technology and Diamond Synthesis forHigher Sensitivity of NV Quantum Sensor
MAKINO, Toshiharu, Advanced Power Electronics ResearchCenter, The National Institute of Advanced Industrial Science andTechnology
Host in iJURC MIZUOCHI, Norikazu
STARTING-UP SUBJECTS(ON-DEMAND FROM RELATED COMMUNITIES)
Fabrication of Novel Cell Culture Substrates Using Well-Defined
Porous Materials
YOSHIKAWA, Chiaki, National Institute for Materials Science(NIMS), Research Center for Functional Materials
Host in iJURC TSUJII, Yoshinobu
I F
Synthesis and Characterization of Raw and Polymerized Asian
Lacquer Samples: towards the Development of a Comprehensive
Collection of Lacquer Reference Samples for Materials Science
and Conservations Studies
BONADUCE, Ilaria, Department of Chemistry and Industrial
Chemistry, University of Pisa
Host in iJURC PINCELLA, Francesca
I F
Analysis of Novel Transporters for Strigolactones or Their
Biosynthetic Intermediates
ZHAO, Yunde, Department of Cell and Developmental Biology,
University of California San Diego
Host in iJURC MASHIGUCHI, Kiyoshi
I

ICR ANNUAL REPORT, 2023

71

Precise Synthesis and Viscoelastic Properties of Ring Polymers
with High Purity and High Molecular Weight
TAKANO, Atsushi, Department of Molecular and Macromolecular
Chemistry, Nagoya University
Host in iJURC MATSUMIYA, Yumi
I

Exploiting AtMYB60 Regulation for Water Use Efficiency andDrought Resistance in Crops
GALBIATI, Massimo, National Council of Research (CNR),
Institute of Agricultural Biology and Biotechnology (IBBA)
Host in iJURC TSUGE, TomohikoI

Evaluation of Mechanical Properties for Polymer Elastomers
with Pseudo-Rotaxane Type Cross-Links
URAKAWA, Osamu, Department of Macromolecular Science,
Osaka University
Host in iJURC MATSUMIYA, Yumi
I

Chromatin, Epigenetic and Proteolytic Regulation of RNA
Processing in Plant Morphogenesis
RUBIO, Vicente, National Center of Biotechnology (CNB-CSIC),
Plant Molecular Genetics Department
Host in iJURC TSUGE, Tomohiko
I

Involvement of Phospholipids in Cytoplasmic Streaming in Plant
Cells
UEDA, Haruko, Osaka University, Department of Macromolecular
Science
Host in iJURC AOYAMA, Takashi
F

Self-Assembling Compounds That Selectively Inhibit Protein
Phase-Separation
ZHOU, Lu, School of Pharmacy, Fudan University
Host in iJURC UESUGI, Motonari
I

Analysis of Membrane Lipid-Dependent Fermentation StressResponse in Acetic Acid Bacteria
TOYOTAKE, Yosuke, Department of Biotechnology, Ritsumeikan
University
Host in iJURC KURIHARA, Tatsuo
Studies on the Structures and Functions of Two Alanine Dehydrogenases in Geobacillus Kaustophilus
OMORI, Taketo, Department of Biomedical Engineering, Osaka
Institute of Technology
Host in iJURC KURIHARA, Tatsuo
Separation of Rare Earth Elements Using Solvent ImpregnatedResin Using Surfactants
KURAHASHI, Kensuke, Environmental and Materials Chemistry
Course, Osaka Metropolitan University College of Technology
Host in iJURC SOHRIN, Yoshiki
Observation of Photothermal Conversion in 3D Quantum Dot
Superlattices Using Pump-Probe Transient Absorption Spectroscopy
GONOME, Hiroki, Graduate School of Science and Engineering,
Yamagata University
Host in iJURC SARUYAMA, Masaki
Development of Cooperative Catalysis by Hybridization of
Supported Metal Nanoparticles with Metal Oxide Clusters
YAMAZOE, Seiji, Graduate School of Science, Tokyo Metropolitan University
Host in iJURC TERANISHI, Toshiharu
Study and Experiment of the High-Energy Electron Generationby the High-Power Laser-Irradiation to the Stacked CNT Target
MATSUI, Ryutaro, Graduate School of Energy Science, Kyoto
University
Host in iJURC TOKITA, Shigeki
EXPANDING SUBJECTS(ON-DEMAND FROM RELATED COMMUNITIES)
Role of PIP5K Genes in Pollen Tube Development
QU, Li-Jia, School of Life Sciences, Peking University
Host in iJURC AOYAMA, Takashi

I

Molecular Mechanisms of mRNA Processing Governing 3’UTR
Ends by Using Plant as a Model System
JARMOLOWSKI, Artur, Department of Gene Expression,
Adam Mickiewicz University, Institute of Molecular Biology andBiotechnology
Host in iJURC TSUGE, TomohikoI

72

Development of Cancer Vaccine Adjuvants with Optimized
Safety Profiles
LI, Yan-Mei, Department of Chemistry, Tsinghua University
Host in iJURC UESUGI, Motonari
I F
Red and Near-Infrared Multi-Resonance Thermally Activated
Delayed Fluorescence Emitters
BEDNAREK, Christin, Karlsruhe Institute of Technology, Institutof Organic Chemistry, IOC
Host in iJURC KAJI, Hironori
I
Construction of Heterologous Protein Secretion System at Low
Temperatures by Using Cold-Adapted Microorganisms
DAI, Xianzhu, College of Resources and Environment, Southwest
University
Host in iJURC KURIHARA, Tatsuo
I F
Structural and Functional Analysis of the Surface Polysaccharidesof Outer Membrane Vesicles Released by Bacteria
CORSARO, Maria Michela, Department of Chemical Sciences,
University of Naples Federico II
Host in iJURC KURIHARA, Tatsuo
I FHigh Pressure Synthesis of the Metastable Rare-Earth Nickelateswith Ni-Site Substitutions for Synchronizing Their Electronic
Phase Transition and Potential Magnetic Transitions
CHEN, Jikun, School of Materials Science and Engineering,
University of Science and Technology Beijing, RP China
Host in iJURC SHIMAKAWA, Yuichi
I
Formation of Authigenic CaCO3 on the Ocean Floor below theCompensation Depth
CAI, Pinghe, Department of Marine Chemistry and Geochemistry,
Xiamen University
Host in iJURC SOHRIN, Yoshiki
I
Fabrication of Nanotopographical Polymer Surfaces for Bactericidal Properties-V
ENDOH, Maya, Department of Material Science and Chemical
Engineering, Stony Brook University
Host in iJURC TAKENAKA, Mikihito
I FInterdisciplinary Approach to Nanostructured Materials forApplications
BUCHER, Jean-Pierre, Strasbourg Institute of Material Physics
and Chemistry
Host in iJURC TERANISHI, Toshiharu
I
Search for Four-Wave-Mixing in the Vacuum - Unveiling Dark
Components in the Universe HOMMA, Kensuke, Graduate School of Advanced Science andEngineering, Hiroshima University
Host in iJURC TOKITA, Shigeki
I

ACTIVITIES OF INTERNATIONAL JOINT USAGE/RESEARCH CENTER

Advanced Oxygen – Mediated Flow Chemistry
THOMAS, Wirth, School of Chemistry, Cardiff University
Host in iJURC NAKAMURA, Masaharu

I

Novel Strategy for Intracellular Delivery of Nanomedicines
PUJALS, Sílvia, Institute for Advanced Chemistry of Catalonia(IQAC)
Host in iJURC FUTAKI, Shiroh
I F
Structural and Functional Analysis of Curvature-Inducing Eptides
and ApplicationULRICH, S. Anne, Karlsruhe Institute of Technology (KIT),
Institute of Organic Chemistry (IOC) and Institute of BiologicalInterfaces (IBG-2)
Host in iJURC FUTAKI, Shiroh
I F
Molecular Mechanisms for the Inactivation of a Growth Hormone
in RiceHE, Zuhua, Institute of Plant Physiology and Ecology, Chinese
Academy of Sciences
Host in iJURC YAMAGUCHI, Shinjiro
I
Cycloparaphenylenes and Chiral Fullerenes for SupramolecularArchitectures in Chiroptical Applications
FUCHTER, Matthew J., Imperial College London (ICL),
Chemistry
Host in iJURC YAMAGO, Shigeru
I
Chiral Cyclophenylene with an [2.2]Paracyclophane CoreBRÄSE, Stefan, Karlsruhe Institute of Technology, Institut of
Biological and Chemical System, IBCS-FMS
Host in iJURC YAMAGO, Shigeru
I
Development of Multi-Dimensional Perovskite Light-Emission
and Photo-Response Materials
LIN, Hao-Wu, Department of Materials Science and Engineering,
National Tsing Hua University, Taiwan
Host in iJURC WAKAMIYA, Atsushi
I
Correlation of Concentration and Orientation Fluctuations in
Mixture of Liquid Crystal/Solvent Isotropic One-Phase StateSHIMADA, Ryoko, Department of Mathematics, Physics andComputer Science, Japan Women’s University
Host in iJURC SATO, Takeshi
I F
Real-Time Visualization of Cellular Phase-Separating Proteins
KIKUCHI, Kazuya, Graduate School of Engineering, Osaka
University
Host in iJURC UESUGI, Motonari
Remote Control of Cells by Synthetic Small Molecules
NISHIKAWA, Makiya, Faculty of Pharmaceutical Sciences,
Tokyo University of Science
Host in iJURC UESUGI, Motonari
Investigation of Donor-Acceptor Molecular Systems by Quantum
Chemical Calculations and Atomic-Scale Spectroscopy
KIMURA, Kensuke, Surface and Interface Science Laboratory,
RIKEN
Host in iJURC KAJI, Hironori
Functional Analysis and Applications of Extracellular Vesicles
Produced by Intestinal Bacteria
YAMASAKI, Shino, Department of Life Science and Biotechnology, Kansai University
Host in iJURC KURIHARA, Tatsuo
FElectrochemical Control of Metal Oxides and Exploration of
Their Functional Properties
TSUCHIYA, Takashi, International Center for Materials Nanoarchitectonics , National Institute for Materials Science
Host in iJURC KAN, Daisuke
Polymer-Brush-Decorated Hybrid Particles as Lubricant Additives
OHNO, Kohji, Osaka Metropolitan University
Host in iJURC TSUJII, Yoshinobu
Manipulation of Three Dimensional Structure of Polymer
Monoliths by 3D Printer
MURASE, Hitoki, Kyoritsu Women’s University
Host in iJURC TSUJII, Yoshinobu
Room Temperature Operable CdS/CdTe Type II Dimer-Quantumdot Diode
MAJIMA, Yutaka, Institute for innovative Research, Tokyo
Institute of Technology
Host in iJURC TERANISHI, Toshiharu
Measurement of Quasi-Stable Strong Magnetic Field by the Interaction between a High-Power Laser and Structured Medium
KISHIMOTO,Yasuaki, Graduate School of Energy Science,
Kyoto University
Host in iJURC TOKITA, Shigeki
Investigation of Cellular Uptake Mechanism Using Extracellular
VesiclesEGUCHI, Akiko, Department of Gastroenterology and Hepatology,
Graduate School of Medicine, Mie University
Host in iJURC FUTAKI, Shiroh
F
Design of Intracellular Delivery Systems for Extracellular Vesicles
NAKASE, Ikuhiko, Department of Biological Chemistry, Graduate
School of Science, Osaka Metropolitan University
Host in iJURC FUTAKI, Shiroh
Functional Analysis of Non-Canonical Strigolactones as Plant
Hormones and Root-Derived Signals
SETO, Yoshiya, School of Agriculture, Meiji University
Host in iJURC YAMAGUCHI, Shinjiro
Development of Structurally Well-Defined Branched Supramolecular Polymers
HAINO, Takeharu, Graduate School of Advanced Science andEngineering, Hiroshima University
Host in iJURC YAMAGO, Shigeru
SUBJECTS FOCUSING OF JOINT USAGE OF iJURC/ICR FACILITIESMicrostructural Investigation by Atomic Resolution Transmission
Electron Microscopy of Novel Alloys
CHOMSAENG, Natthaphol, Advanced Materials Engineering,
Burapha University
Host in iJURC HARUTA, Mitsutaka
IElectron Energy Loss Spectroscopy and High-Resolution Transmission Electron Microscopy of Novel Functional Materials
CHAIRUANGSRI, Torranin, Industrial Chemistry, Chiang Mai
University
Host in iJURC HARUTA, MitsutakaI

ICR ANNUAL REPORT, 2023

73

Plasmon Excitations in Charge-Density-Wave Systems: A
Momentum-Dependent Electron-Energy Loss Spectroscopy
Investigation
CHU, Ming-Wen, Center for Condensed Matter Sciences, National
Taiwan University
Host in iJURC HARUTA, MitsutakaI

A novel Interdisciplinary Approach to Cancer Metabolism Researchby Solid State Nuclear Magnetic Resonance Spectroscopy
ITO, Takahiro, Institute for Life and Medical Sciences, Kyoto
University
Host in iJURC KAJI, Hironori

High-Pressure Synthesis of Transition Metal Oxides with Novel
Properties
JI, Kunlang, Centre for Science at Extreme Conditions andSchool of Chemistry, University of Edinburgh
Host in iJURC SHIMAKAWA, Yuichi
I
Elucidation of Hydrogen and Helium Retention Behavior in
Fusion Materials
MIYAMOTO, Mitsutaka, Interdisciplinary Faculty of Scienceand Engineering, Shimane University
Host in iJURC HARUTA, Mitsutaka
Nano Structural Analysis of Cs4PbBr6/CsPbBr3 Composite for theDevelopment of a Scintillator for Fast Electron Beam Detection
with High Efficiency
SAITO, Hikaru, Institute for Materials Chemistry and Engineering,
Kyushu University
Host in iJURC HARUTA, Mitsutaka
Optimization of Laser Irradiation Conditions for High-Quality
Ion beam Generation by Laser-Driven Ion Acceleration
KOJIMA, Sadaoki, Kansai Institute for Photon Science, National
Institutes for Quantum Science and Technology
Host in iJURC TOKITA, Shigeki
Mass Spectrometry Analysis for the Production of Advanced
Chemical Materials from the Efficient Chemical Decomposition
Process of Cedar Wood Tissue Structure
HATANO, Osamu, Faculty of Medicine, Nara Medical University
Host in iJURC NAKAMURA, Masaharu
Theoretical Design of Low-Dimensional Silicon Material
Embedded in a Flat Two-Dimensional Sheet and Exploration for
Operating Principles
TAKAHASHI, Masae, Graduate School of Science, Tohoku
University
Host in iJURC MIZUHATA, Yoshiyuki
F
SUBJECTS ENCOURAGING JOINT PROGRAM
Determine the Three-Dimensional Structure of 13C=18O Labeled
α-Synuclein(61-95) in the Langmuir-Blodgett Film and Supported
Phospholipid Bilayer by MAIRS2
WANG, Chengshan, Department of Chemistry, Middle Tennessee
State University
Host in iJURC HASEGAWA, Takeshi
I
High-Efficacy Protein Chemical Synthesis
HOJO, Hironobu, Institute for Protein Research, Osaka University
Host in iJURC FUTAKI, Shiroh
I
Modulation of In-Cell Protein-Protein Interactions Using MidSized Peptides
TAMAMURA, Hirokazu, Institute of Biomaterials and Bioengineering (IBB-TMDU), Tokyo Medical and Dental University
Host in iJURC FUTAKI, Shiroh
I
The 17th International Workshop for East Asian Young Rheologists
INOUE, Tadashi, Department of Macromolecular Science, Osaka
University
Host in iJURC MATSUMIYA, Yumi
I

74

ACTIVITIES OF INTERNATIONAL JOINT USAGE/RESEARCH CENTER

iJURC Publications (Selected Examples)(until 31 May 2023)
Field-Free Superconducting Diode Effect in NoncentrosymmetricSuperconductor/Ferromagnet Multilayers
Narita, H.; Ishizuka, J.; Kawarazaki, R.; Kan, D.; Shiota, Y.;
Moriyama, T.; Shimakawa, Y.; Ognev, A. V.; Samardak, A. S.;
Yanase, Y.; Ono, T., Nat. Nanotechnol., 17, 823-828 (2022).
Abstract
The diode effect is fundamental to electronic devices and is widelyused in rectifiers and a.c.–d.c. converters. At low temperatures,
however, conventional semiconductor diodes possess a highresistivity, which yields energy loss and heating during operation.
The superconducting diode effect (SDE), which relies on broken
inversion symmetry in a superconductor, may mitigate this obstacle:
in one direction, a zero-resistance supercurrent can flow throughthe diode, but for the opposite direction of current flow, the device
enters the normal state with ohmic resistance. The application ofa magnetic field can induce SDE in Nb/V/Ta superlattices with apolar structure, in superconducting devices with asymmetric patterning of pinning centres or in superconductor/ferromagnet
hybrid devices with induced vortices. The need for an external
magnetic field limits their practical application. Recently, a fieldfree SDE was observed in a NbSe2/Nb3Br8/NbSe2 junction; it
originates from asymmetric Josephson tunnelling that is inducedby the Nb3Br8 barrier and the associated NbSe2/Nb3Br8 interfaces.
Here, we present another implementation of zero-field SDE using
noncentrosymmetric [Nb/V/Co/V/Ta]20 multilayers. The magnetic
layers provide the necessary symmetry breaking, and we cantune the SDE by adjusting the structural parameters, such as theconstituent elements, film thickness, stacking order and numberof repetitions. We control the polarity of the SDE through themagnetization direction of the ferromagnetic layers. Artificiallystacked structures, such as the one used in this work, are of particular interest as they are compatible with microfabrication techniques and can be integrated with devices such as Josephson
junctions. Energy-loss-free SDEs as presented in this work may
therefore enable novel non-volatile memories and logic circuitswith ultralow power consumption.
Synergistic Surface Modification of Tin–Lead Perovskite
Solar Cells
Hu, S.; Zhao, P.; Nakano, K.; Oliver, R. D. J.; Pascual, J.; Smith,J. A.; Yamada, T.; Truong, M. A.; Murdey, R.; Shioya, N.; Hasegawa,
T.; Ehara, M.; Johnston, M. B.; Tajima, K.; Kanemitsu, Y.; Snaith,
H. J.; Wakamiya, A., Adv. Mater., 35(9), 2208320 (2023).
Abstract
Interfaces in thin-film photovoltaics play a pivotal role in determining device efficiency and longevity. In this work, the top
surface treatment of mixed tin–lead (≈1.26 eV) halide perovskite
films for p–i–n solar cells is studied. Charge extraction is promoted by treating the perovskite surface with piperazine. This
compound reacts with the organic cations at the perovskite
surface, modifying the surface structure and tuning the interfacial
energy level alignment. In addition, the combined treatment with
C60 pyrrolidine tris-acid (CPTA) reduces hysteresis and leads toefficiencies up to 22.7%, with open-circuit voltage values reaching
0.90 V, ≈92% of the radiative limit for the bandgap of this material.
The modified cells also show superior stability, with unencapsulated cells retaining 96% of their initial efficiency after >2000 h ofstorage in N2 and encapsulated cells retaining 90% efficiency after>450 h of storage in air. Intriguingly, CPTA preferentially binds
to Sn2+ sites at film surface over Pb2+ due to the energeticallyfavored exposure of the former, according to first-principles
calculations. This work provides new insights into the surface

chemistry of perovskite films in terms of their structural, electronic,
and defect characteristics and this knowledge is used to fabricate
state-of-the-art solar cells.
LiNbO3-Type Polar Antiferromagnet InVO3 Synthesizedunder High-Pressure Conditions
Tan, Z.; Lussier, J. A.; Yamada, T.; Xu, Y.; Saito, T.; Goto, M.;
Kosugi, Y.; Vrublevskiy, D.; Kanemitsu, Y.; Bieringer, M.;
Shimakawa, Y., Angew. Chem. Int. Ed., 61(25), e202203669 (2022).
Abstract
The ambient pressure cation disordered InVO3 bixbyite has been
predicted to form a GdFeO3-type perovskite phase under highpressure and high temperature. Contrary to the expectation,
InVO3 was found to crystallize in the polar LiNbO3-type structurewith a calculated spontaneous polarization as large as 74 μC cm−2.
Antiferromagnetic coupling of V3+ magnetic moments and acooperative magnetic ground state below about 10 K coupledwith a polar structure suggest an intriguing ground state of thenovel LiNbO3-type high-pressure InVO3 structure.
Nitrogen Reduction by the Fe Sites of Synthetic [Mo3S4Fe]
Cubes
Ohki, Y.; Munakata, K.; Matsuoka, Y.; Hara, R.; Kachi, M.; Uchida,K.; Tada, M.; Cramer, R. E.; Sameera, W. M. C.; Takayama, T.;
Sakai, Y.; Kuriyama, S.; Nishibayashi, Y.; Tanifuji, K., Nature,
607, 86-90 (2022).
Abstract
N2 fixation by Nature is performed by nitrogenase, which employsa unique transition metal-sulfur-carbon cluster as its active-site
cofactor ([(R-homocitrate)MoFe7S9C], FeMoco). Whereas synthetic
counterparts of FeMoco, metal-sulfur clusters, have displayedbinding of N2 in a few examples, the reduction of N2 by thisclass of compounds has been unknown. Here we show that the Featoms in our [CpR3Mo3S4Fe] cubes (CpR = C5Me5, C5Me4SiMe3,
and C5Me4SiEt3) capture an N2 molecule and catalyze N2 silylation
to form N(SiMe3)3 under treatment with excess Na and Me3SiCl.
These results exemplify the first catalytic N2 reduction by asynthetic metal-sulfur cluster with an Fe center supported only by
S ligands. This work demonstrates the N2-reducing capability of
Fe atoms in a S-rich environment, which Nature has selected toaccomplish a similar purpose.
“Mamonoviridae”, a Proposed New Family of the Phylum
Nucleocytoviricota
Zhang, R.; Takemura, M.; Murata, K.; Ogata, H., Arch. Virol.,168, 80 (2023).
Abstract*
Acanthamoeba castellanii medusavirus J1 is a giant virus thatwas isolated from a hot spring in Japan in 2019. Recently, a close
relative of this virus, named medusavirus stheno T3, was isolated
in Japan. Here, we describe their morphological, genomic, andgene content similarities and also propose to create a new family,“Mamonoviridae”, a new genus, “Medusavirus”, and two species,“Medusavirus medusae” and “Medusavirus sthenus”, to classify
these two viruses within the phylum Nucleocytoviricota.
*Permission to use this abstract was obtained from Springer
Nature by Hiroyuki Ogata.

ICR ANNUAL REPORT, 2023

75

VISITING PROFESSORS’ACTIVITIES IN ICR

Laboratory of Synthetic Organic Chemistry

Laboratory of Chemical Biology

Professor, Nagoya University(Chikusa, Nagoya, Aichi 464-8601)

Chief Scientist, Synthetic Organic Chemistry
Laboratory, RIKEN(2-1, Hirosawa, Wako, Saitama 351-0198)

Lecture at ICR
Toward Catalytic Control of Photo-induced
Radical Reactions
Vis Prof
OOI, Takashi(D Sc)Vis Prof
TANAKA, Keiji(D Eng)Vis Prof
SODEOKA, Mikiko(D Pharm)
Laboratory of Polymer Materials Science

Laboratory of Synthetic Organotransformation

Distinguished Professor, Department ofApplied Chemistry, Kyushu University(744 Motooka Nishi-ku, Fukuoka 819-0395)

Professor, Department of Chemistry, The
University of Tokyo(Hongo, Bunkyo, Tokyo 113-0033)

Lecture at ICR
Innovative Adhesion Technology Basedon 4-dimensional Multi-Scale Analysis ofInterfaces

Lecture at ICR
1. Organic Chemistry: From the Basics to
the Current Style
2. Organic Chemistry: From Structure andSynthesis to Boundaries

Vis Prof
ISOBE, Hiroyuki(D Sc)

Laboratory of Organometallic Chemistry

Laboratory of Advanced Solid State
Chemistry

Associate Professor, Department of Chemistry,
University of Colombo(00300, Colombo, Sri Lanka)

Professor, Department of Inorganic Chemistry,
Complutense University of Madrid(Plaza de las Ciencias Ciudad Universitaria
28040, Madrid, Spain)
Vis Prof
GARCIA MARTIN, Susana(Ph D)Vis Assoc ProfSHINYA, Hikari(D Sc)

Lecture at ICR
Recent Research Activities in Complutense
University of Mardrid

Lecture at ICR
Introduction to Computational Chemistry
Vis Assoc ProfSAMEERA, W. M. C.
(Ph D)

Laboratory of Nanospintronics

Laboratory of Molecular Materials Chemistry

Project Associate Professor, Center for
Spintronics Research Network (CSRN), The
University of Tokyo
(7-3-1 Hongo, Bunkyo, Tokyo 113-8656)

Senior Researcher, Surface and Interface
Science Laboratory, RIKEN(Wako, Saitama 351-0198)

Lecture at ICR
First-Principles Studies on Spintronics
Materials

Vis Assoc ProfIMADA, Hiroshi(D Eng)Laboratory of Laser Matter Interaction
Science

Lecture at ICR
Research on Ultrafast Mid-Infrared Lasers
Using Fe-Doped Chalcogenide Crystals

Prof Em / Specially Appointed ProfTOKITOH, Norihiro (D Sc)

78

VISITING PROFESSORS’ ACTIVITIES IN ICR

Lecture at ICR
Depeloping Various Dimer Systems Basedon Single-Molecule Manipulation Techniquesand Evaluation of Their Optical Properties

Laboratory of Bio-knowledge Engineering
Project Leader, National Institutes of Biomedical Innovation, Health and Nutrition(7-6-8, Saito-Asagi, Ibaraki, Osaka 5670085)

Professor, National Institute for Fusion
Science(322-6 Oroshi-cho, Toki, Gifu 509-5292)
Vis Assoc ProfYASUHARA, Ryo(D Eng)Lecture at ICR
1. Development of Bifunctional Fluoroalkylation
2. ReactionsTurn-ON Fluorescent Affinity
Labeling

Vis Assoc ProfNATSUME, Yayoi(D Agr)Lecture at ICR
Exploring Possible Drug-Target Molecules
Based on Network Data-Driven Integrative
Machine Learning
Prof Em / Specially Appointed Prof
KANEHISA, Minoru (D Sc)

PERSONAL

Retirement

Professor AOYAMA, Takashi
Division of Biochemistry– Molecular Biology –On March 31st, 2024, Dr. Takashi Aoyama retired from
Kyoto University after 39 years of service and was honoredwith the title of Professor Emeritus of Kyoto University.
Dr. Aoyama was born in Osaka Prefecture on November
7th, 1958. He graduated from the Faculty of Science, Kyoto
University, majoring in Biological Sciences in 1981. Hethen proceeded to Graduate School of Science, Kyoto
University, where he studied molecular mechanisms ofgene expression regulation under the supervision of lateProfessor Mitsuru Takanami. In 1985, he left Graduate
School to be appointed as Research Associate at Institutefor Chemical Research, Kyoto University. In 1988, he wasappointed Assistant Professor of Institute for Chemical
Research, Kyoto University, and promoted to Associate
Professor in 1994, and to Professor in 2009, directing theLaboratory of Molecular Biology. In 1987, he was granted
a doctoral degree with the thesis entitled “Essential structureof E. coli promoter”. On leave from the University during
1991 to 1993, he joined the Laboratory of Plant Molecular
Biology, directed by Professor Nam-Hai Chua at The
Rockefeller University.
Dr. Aoyama devoted himself in understanding the molecular function regulating gene transcription. His researchstarted from studying the basic structure sequence elements
determining the promoter function in Escherichia coli.
Then he elucidated the gene expression control mechanism
for T-DNA transfer and its integration into a plant nuclear
genome from Agrobacterium rhizogenes and A. tumefaciens
species. During his stay at The Rockefeller University,
he development a novel chemical induction system fortranscription in plants, utilizing the regulatory mechanismof vertebrate steroid hormone receptors. He developed achimeric transcription factor that combined the receptor
domain of the mammalian glucocorticoid receptor GR, thetranscription activation domain of the herpesvirus transcription factor VP16, and the DNA binding domain of the
Saccharomyces cerevisiae transcription factor GAL4. By
expressing this chimeric transcription factor GVG intransformed plants, he established a chemical transcription
induction system that effectively works in individual
plants, for the first time. Today, this novel system is openly
used in basic research and is applied in the commercial
research field through licensed patents.

80

PERSONAL

His investigation of the transcriptional control networkin plant cell morphogenesis, and the following elucidationof the regulation in plant lipid signaling, were all foundedon his unique style of research utilizing reverse genetic
methods and plant transformants. He took advantage of thechemically induced reverse genetic methods to investigate
the downstream of the transcription factor GL2, whichplays a central role in the formation of single-celled trichomes and root hairs. He designed an extensive genesearch strategy using the model plant Arabidopsis thaliana,
and identified genes encoding the lipid metabolic enzyme
PLDζ1 and genes encoding bHLH-type transcription factors as direct target genes. Achievements on PLDζ1 were
published in the Science journal in 2003 and was featured
on the cover page, as important evidence showing the involvement of lipid signaling in plant cell morphogenesis.
He then expanded his research interests to the role oflipid signals in plant cell morphogenesis, and analyzed thebiological functions of PLD and PIP5K. Studies using root
hair cells and pollen, as a model for single cell morphogenesis, revealed that PIP5K and its product PI(4,5)P2 playa central role together with small G proteins in establishingand maintaining intracellular polarity. In addition to this,the research of analyzing the loss of function mutants of thenine major PIP5K genes of Arabidopsis and their multiple
mutants have been internationally recognized as diligent,
outstanding, field-leading work, to the complete the serial
elucidation of the role of PI(4,5)P2 signals in plants.
He has been invited to give keynote lectures at numerous
international conferences. His achievements have been
published in 70 original academic papers in international
journals, 15 reviews and commentaries, and 11 co-authoredbooks. He has also contributed to the field of plant science,serving as the secretary-general of the Japanese Society ofPlant Physiologists and on the editorial board of the international journal, Plant Cell and Physiology.
Throughout his career, he enlightened many followers
not only at Kyoto University but also at other universities
and institutes with his thoughtful character. His contribution
to Kyoto University and the Institute for Chemical
Research through his scientific, educational, and admin­
istrative activities is hereby greatly acknowledged.

Retirement

Professor KANEMITSU, YoshihikoInternational Research Center of Elements Science– Nanophotonics –On March 31st 2024, Professor Yoshihiko Kanemitsu
retired from Kyoto University and was honored with thetitle of Professor Emeritus of Kyoto University. Dr.
Kanemitsu joined the Institute for Chemical Research in2004 as a professor of physics. He set up a new laboratory
for semiconductor physics and optical materials scienceas part of the International Research Center of Elements
Science.
Throughout his academic career, Professor Kanemitsu
has explored unique optical and electronic properties ofsemiconductors by applying various laser spectroscopic
techniques. Semiconductor bulk crystals and nanomaterials
are widely used in solar cells, light-emitting diodes, lasers,
and other optoelectronic devices. His fundamental work
has contributed to our basic understanding of semiconductor
photophysics, helped improve the performance of optoelectronic devices, and led to the development of newconcepts in optoelectronics. His outstanding achievements
center on the exciton physics of semiconductor nanomaterials
and the photophysics of perovskite-type semiconductors.
Professor Kanemitsu developed space- and time-resolved
laser spectroscopy apparatus and methods for the study of
optical properties of semiconductor quantum structures,
including single-dot spectroscopy, photon correlation
spectroscopy, and femtosecond transient absorption spectroscopy. He studied the luminescence spectra of isolated
carbon nanotubes and single nanocrystals at low temperatures and elucidated their complicated excited state structures. He also clarified the important role of excitons, trions,and biexcitons in governing the luminescence spectra ofcarbon nanotubes and nanocrystals. In addition, he discovered the coherent state of multiple excitons in nanocrystals,
as well as high-order harmonic light emission from nanocrystals. These findings highlight the importance of precise
control of the exciton dynamics and exciton complexes for
improving the performance of nanomaterial-based photonic devices. He also presented new device concepts basedon nanomaterials with high-efficiency nonlinear opticalresponse.
Professor Kanemitsu has also contributed extensively tothe area of metal-halide perovskite semiconductors. After
showing that halide perovskites are direct-gap semiconductors, he confirmed that the efficient luminescence is due

to free carrier band-to-band recombination. He also discovered the phenomena of efficient photon recycling inthick perovskite single crystals. These seminal studies explained the reasons why halide perovskites are such excellent materials for solar cells. Along the way, he exploredunique nonlinear optical phenomena such as high-orderharmonic light emission, the Autler-Townes effect, andnegative thermo-optic coefficients in these materials. His
pioneering works in this area opened a new avenue ofsemiconductor optics and optoelectronic applications.
As a leading scientist in his field, Professor Kanemitsu
has many other accomplishments. He served as the chairman of the 125 Committee on Mutual Conversion between
Light and Electricity, The Japan Society of the Promotion of Science, and as an R&D management committee
member of the ALCA and MIRAI programs, Japan Scienceand Technology Agency. He is also a member of several
advisory committees of international conferences for
optical spectroscopy of condensed matter. He establishedthe Endowed Research Section at the Institute for Chemical
Research supported by the Sumitomo Electric Group CGR
Foundation.
Throughout his career, Professor Kanemitsu has publishedover 400 papers and presented many invited talks at international conferences and meetings. His achievements
have been internationally recognized, and he has received
many awards and prizes including the Marubun Research
Encouragement Award (1998), Phosphor Award (2004),
The Ichimura Prize in Science for Distinguished Achievement (2005), The Inoue Prize for Science (2006), The
Yazaki Science Award (2006), The Eto-Hosoya Prize(2018), The Shimadzu Prize (2019), The Kato Memorial
Award (2019), The Ichimura Prize for Science against
Global Warming for Distinguished Achievement (2021),
American Physical Society Outstanding Referee (2022),
and The Commendation for Science and Technology by the
Minister of Education, Culture, Sports, Science andTechnology (2022). In 2023 he was made a fellow of theJapanese Society for Applied Physics.
His contribution to Kyoto University through his scientific,
educational, and administrative activities is acknowledged.
His warm and sincere personality will remain deep in thehearts of his colleagues and students.

ICR ANNUAL REPORT, 2023

81  Awards

TAMAO, Kohei

SARUYAMA, Masaki

Order of Culture

Nanoscale Horizons Award

Cabinet Office, Government of JapanThe 21st Annual Meeting of the Society of Nanoscience andTechnology

3 November 2023

“Structural Control of Three-Dimensional Nanocrystal
Superlattice”
The Society of Nano Science and Technology
13 May 2023

Young Scientist Award

KANEHISA, Minoru

Division of Colloid and Surface Chemistry

Highly Cited Researcher 2023

The Chemical Society of Japan“Exploration of Diverse Nanomaterials Based on the Precise
Chemical Synthesis of Inorganic Nanocrystals”
12 September 2023

Clarivate
15 November 2023

ZHU, Lingkai
TOKITOH, Norihiro

Oral Presentation Award for Young Scientist

The 10th Japan Physical Organic Chemistry Award“Synthesis of 3D Ag Nanoparticle Superlattices and Their
Structure-Specific Functions”

The 74th Divisional Meeting of Division of Colloid andSurface Chemistry“Challenging Research toward the Creation of Unexplored
Molecules of Heavier Main Group Elements”

The Chemical Society of Japan
31 October 2023

The Society of Physical Organic Chemistry, Japan
14 September 2023

HERBSCHLEB, Ernst DavidNAGAO, Kazunori
The Young Scholar Lectures of the Chemical Society ofJapan“Carbocation Generation through Light-Driven Radical-Polar
Crossover and the Application to Bond Formation Reaction”
The Chemical Society of Japan
22 March 2023

82

PERSONAL

Young Scientist Award of the Physical Society of Japan,
2023“Study of Coherence in Solid Materials and its Exploitation for
Quantum Sensing”
The Physical Society of Japan
23 March 2023

KARUBE, Shutaro

TAGA, Kotaro

The Japan Institute of Metals and Materials Young
Researcher Award

Student Presentation Award of the Physical Society ofJapan (Division 3)“Creation of Novel Spin-Orbit Materials and Research on the
Principle of Spin Current Generation”

JPS 78th Annual Meeting

The Japan Institute of Metals and Materials
20 September 2023

“Frequency and Magnetic Field Angle Dependence of the
Coupling between Spin Wave and Surface Acoustic Wave in
NiFe Thin Film”
The Physical Society of Japan
14 October 2023

NARITA, Hideki
Young Scientist Research Award
The 14th JSAP Superconductors Division“Field-Free Superconducting Diode Effect inNoncentrosymmetric Superconductor/Ferromagnet
Multilayers”
JSAP Superconductors Division
15 March 2023

HTSF Young Scientist Research AwardThe 6th High Temperature Superconductivity ForumIMANISHI, Miki
The 28th SJWS Award“Development of an Enzymatic Detection Method for RNA
Methylation and Its Application”
The Society of Japanese Women Scientists
28 May 2023

“Field-Free Superconducting Diode Effect in Superconductor/
Ferromagnet Multilayers”
High Temperature Superconductivity Forum2022 Tanaka Kikinzoku Memorial
Foundation Young Researcher Award

21 March 2023

“Control of Magnetic Superconductors Using Noble Metals
and Development of Non-Volatile Superconducting Devices”
Tanaka Kikinzoku Memorial Foundation
31 March 2023

KURIYAMA, Masashi
Best Presentation Award for Young Scientists

FUNADA, Shinsaku

The 96th Annual Meeting of the Japanese Biochemical Society

The 54th JSAP Young Scientist Presentation Award

The Japanese Biochemical Society“Correlation Analysis Between Peptide-mediated Intracellular
Delivery Efficiency and Gene Expression”

The 70th JSAP Spring Meeting 2023

31 October 2023

“Electrical Detection of Antiferromagnetic Dynamics in GdCo
Thin Films by Using a 154 GHz Gyrotron Irradiation”
The Japan Society of Applied Physics
19 September 2023

ICR ANNUAL REPORT, 2023

83

MICHIBATA, Junya

NAKAGAWA, Yuna

The Best Student Presentation Award (Oral)

Excellent Presentation Award

The 143rd Annual Meeting of the Pharmaceutical Society ofJapan

The 2022 Master’s Thesis Presentation at Graduate School of
Pharmaceutical Sciences, Kyoto University“Liquid-Liquid Phase Separation Formation by
Macromolecule Delivery Peptides Bearing Polysaccharides
and its Application for Cytosolic Antibody Delivery”“Intracellular Delivery of Extracellular Vesicles Using
Macropinocytosis-Inducing Peptide”

The Pharmaceutical Society of Japan
25 April 2023

Best Presentation Award

Graduate School of Pharmaceutical Sciences, Kyoto
University
Best Presentation Award

24 March 2023

The 24th Symposium on Drug Interactions with Biological
Membranes

The 24th Symposium on Drug Interactions with Biological
Membranes“Microparticle Formation by Macromolecule Delivering
Peptides Bearing Polysaccharides and its Application for
Cytosolic Antibody Delivery”“Improvement of the Membrane Fusion of Extracellular
Vesicles by Loading SARS-CoV-2 Spike Proteins”

Division of Physical Sciences, The Pharmaceutical Society ofJapan

Division of Physical Sciences, The Pharmaceutical Society ofJapan
20 October 2023

20 October 2023

OTONARI, Kenko

TOH, Kohei

Chairman’s Special Award

ICR Award for Graduate Students

The 24th Annual Meeting of the RNA Society of Japan“Chemoproteomic Identification of Blue-Light-Damaged
Proteins”“Development of Higher Sequence-Selective andTimingControlled m6A Demethylation Tool”
RNA Japan

1 December 2023

Best Presentation Award for Young Scientists

7 July 2023

The 96th Annual Meeting of the Japanese Biochemical Society“Creation of Higher Sequence-Selective and TimingControlled m6A Demethylation Tool”
The Japanese Biochemical Society
31 October 2023

84

PERSONAL

Institute for Chemical Research, Kyoto University

SATO, Hiroki

HASEGAWA, Takeshi

The 54th JSAP Young Scientist Presentation Award

Academic AwardThe 70th JSAP Spring Meeting 2023

“Development of Multiple-Angle Incidence Resolution
Spectrometry and its Applications in Thin Film Science”“Analysis of Charge Traps in Organic Amorphous Film by
Multiscale Simulation”

The Spectroscopical Society of JapanThe Japan Society of Applied Physics

5 October 2023
19 September 2023

TAKANO, Shotaro

ZHU, Mengshan

The Okada Prize
The 2023 Fall Meeting of the Oceanographic Society of Japan“Development of an Analytical Method for Trace Metal
Isotopes and Its Application to Marine Chemistry”
The Oceanographic Society of Japan
1 April 2023

The Japan Society for Analytical ChemistryAward for Younger Researchers, 2023

Young Presentation AwardThe 96th Annual Meeting of the Japanese Biochemical Society“A Predicted Glycosyl Transferase Plays a Crucial Role in the
Biogenesis of Extracelluar Membrane Uesicles of Shewanella
vesiculosa HM13”
The Japanese Biochemical Society
31 October 2023

The 72nd Annual Meeting of the Japan Society for Analytical
Chemistry“Isotopic Analysis of Trace Metals for Geochemistry andMarine Chemistry”
The Japan Society for Analytical Chemistry
14 September 2023

NAKAMURA, Tomoya
ZHENG, Linjie

NIPPON SHOKUBAI Award in Synthetic Organic
Chemistry“Development of Monolayer Electron-Collecting Materials for
Efficient Lead-Free Perovskite Solar Cells”

Young Scientist Award
The 119th meeting of the Japan Society for Plasma
Spectrochemistry

The Society of Synthetic Organic Chemistry, Japan (SSOCJ)
15 February 2023

“Establishment of a Simultaneous Analysis for Nine Trace
Metals (Al, Mn, Fe, Co, Ni, Cu, Zn, Cd, and Pb) in Seawaterand Elucidation of their Sectional Distribution in the Pacific
Ocean”

The 12th Research Encouragement Award
for Chemical Innovation

The Japan Society for PLASMA Spectrochemistry

Japan Association for Chemical Innovation (JACI)

12 May 2023

“Material Chemistry Approach for High-Performance
Perovskite Tandem Solar Cells”
26 June 2023

ICR ANNUAL REPORT, 2023

85

TRUONG, Minh Anh

DOBA, Takahiro

ICR Award for Young Scientists

Inoue Research Award for Young Scientists“Tripodal Triazatruxene Derivative as a Face-on Oriented
Hole-collecting Monolayer for Efficient and Stable Inverted
Perovskite Solar Cells”“Iron-Catalyzed C–H/C–H Coupling for Synthesis of Functional
Small Molecules and Polymers”

Institute for Chemical Research, Kyoto University

Inoue Foundation for Science
14 December 2023

1 December 2023

HIRA, Shota
Innovative PV Encouragement AwardThe 20th Next Generation Photovoltaic Power Generation
System Symposium (1st Symposium of The Japan Photovltaic
Society)“Hole-Collecting Monolayer Materials based on Squaraine
Structures for Perovskite Solar Cells”
The Japan Photovoltaic Society (JSES)MINEO, Keito
The Japanese Forest Society Student Award“History of Policies Related to the Supply of Large Timber inJapanese National Forests”
The Japanese Forest Society
25 March 2023

31 August 2023

TOKITA, Shigeki
Distinguished Progress Award“Development of Innovative Power Laser - ConductionCooled Active-Mirror Laser”
The Laser Society of Japan
31 May 2023

SHIMAKAWA, Yuichi
Japan Society of Powder and Powder MetallurgyAward for Distinguished Achievements in Research“Synthesis of New Transition-Metal Oxides Showing Novel
Properties”
Japan Society of Powder and Powder Metallurgy

KIYOMURA, Tsutomu

6 June 2023
The Ceramic Society of Japan Awards for
Academic Achievements in Ceramic Science and Technology

Technical Support Contribution Award“Discovery of Novel Functionalities in Charge-Transition
Oxides”

The 22nd International Nanotechnology Exhibition &Conference“Support for Fine-Structure Analysis by Transmission Electron
Microscopy”
ARIM Japan
1 February 2023

86

PERSONAL

The Ceramic Society of Japan
7 June 2023

OHKI, Yasuhiro

CHO, Kenichi

The Chemical Society of Japan Award for Creative WorkICR Award for Graduate Students

The 103rd CSJ Annual Meeting“Exciton-Phonon and Trion-Phonon Couplings Revealed by
Photoluminescence Spectroscopy of Single CsPbBr3
Perovskite Nanocrystals”“Synthesis of Biomimetic Cluster Complexes and Reductionof Inert Small Molecules”
The Chemical Society of Japan

Institute for Chemical Research, Kyoto University
1 December 2023

23 March 2023

KANEMITSU, Yoshihiko

NAKAGAWA, Kotaro

The 17th JSAP Fellow (2023)

Paper Presentation Encouragement Award“Pioneering Research on Nano-Semiconductor Photophysics
and Photonics”

The 43rd Annual Meeting of The Laser Society of JapanThe Japan Society Applied Physics
19 September 2023

“Controlling High-Order Harmonic Generation Using
Quantum Confinement Effects of Semiconductor
Nanocrystals”
The Laser Society of Japan
31 May 2023

YUMOTO, GoZHANG, Zhenya

Paper Presentation Encouragement Award
The 43rd Annual Meeting of the Laser Society of Japan“Development of Polarization-Resolved Pump-Probe
Microscopy and Observation of Ultrafast Two-Dimensional
Exciton Spin Transport”

ICR Award for Graduate Students

The Laser Society of Japan

Institute for Chemical Research, Kyoto University“Generation of Third-Harmonic Spin Oscillation from Strong
Spin Precession Induced by Terahertz Magnetic near Fields”

31 May 2023

1 December 2023

SAKAMOTO, Minoru

SEKIGUCHI, Fumiya
Excellent Paper Presentation Award

Student Presentation Award of the Physical Society ofJapan (Division 5)

The 43rd Annual Meeting of the Laser Society of Japan

2023 Spring Meeting of the Physical Society of Japan“Polarization Anomaly of High Harmonics Generated from a
Solid Reflecting the Crystal Symmetry and Non-Perturbative
Nonlinear Dynamics”“Controlling High Harmonic Generation in GaAs by
Excitation Polarization: Enhancement of Harmonic Yields andEmergence of Nonlinear Optical Activity”

The Laser Society of JapanThe Physical Society of Japan
31 May 2023

31 March 2023

ICR ANNUAL REPORT, 2023

87

DAIKOKU, Yusuke

MENG, Lingjie

Student Presentation Award of the Physical Society ofJapan (Division 5)

ICR Award for Young Scientists

2023 Annual Meeting of the Physical Society of Japan

Institute for Chemical Research, Kyoto University“Light-Induced Phase Separation in ABX3-Type Perovskite
Semiconductors Studied by Hyperspectral Imaging”
The Physical Society of Japan
14 October 2023

ENDO, Hisashi
Oceanochemistry Encouragement Prize“Study on Marine Biogeochemical Cycles Using the Molecular
Biological Techniques”
RIOC, Research Institute for Oceanochemistry Foundation
22 April 2023

88

PERSONAL“Mirusviruses Link Herpesviruses to Giant Viruses”
1 December 2023

  Poster Awards

WANG, Yutang

TAMAMOTO, Ken

Best Poster Award

Excellent Presentation Award

The 57th Meeting for Young Scientists on Organic Reactions

The 31st Polymer Materials Forum“Development of a New Germanium Atom Transfer Reagent”“Visualization and Understanding of Dynamic Wetting and
Fluid Behavior at the Polymer Brush Interface”

Organizing Committee of the 57th Meeting for Young
Scientists on Organic Reactions
12 August 2023

The Society of Polymer Science, Japan
IPC2023 Poster Award: Langmuir Award

25 May 2023

The 13rd SPSJ International Polymer Conference (IPC2023)“Hydration and Anti-Icing Properties of Hydrophilic
Concentrated Polymer Brushes”
The Society of Polymer Science, Japan
21 July 2023

HU, Weizhe

JIANG, Yuhan

Poster AwardBCSJ Award for Poster Presentation

The 33rd Symposium on Physical Organic Chemistry

The 10th Pacific Symposium on Radical Chemistry (PSRC-10)“Circularly Polarized Luminescence Properties of Dibenzo[7]helicenes and Single Crystal Structures Depending on the
Position of Benzo Annulation”“Synthesis of Topological Block Polymers by
Organotellurium-Mediated Emulsion Polymerization in Water”

The Society of Physical Organic Chemistry, JapanBCSJ Award for Poster Presentation

Organization Committee of the 10th Pacific Symposium on
Radical Chemistry (PSRC-10)

14 September 2023

9 June 2023

The 2nd Seminar on International Core-to-Core Project on
Nano Carbon Device Science at Kyoto“Non-Linear Molecular Spring Properties of a Dibenzo[c,u][7]helicene Derivative Derived from Intramolecular NonCovalent Interactions”

KAWASE, Riku

Bulletin of the Chemical Society of Japan
6 October 2023

Poster Presentation Awards for Young Researchers“Control of Impurity Incorporation into CVD Diamond toward
Long Coherence Time of the NV Center by Optimizing
Pressure”
Quantum Innovation 2023
5 December 2023

ICR ANNUAL REPORT, 2023

89

HARIKI, Nene

TOH, Kohei

Best Poster Presentation Award

Best Presentation Award“Improving the Detection Efficiency of Nitrogen-Vacancy
Center ODMR Signal in DNDs”

Drug Discovery Conference 2023 Yugawara

The Quantum Life Science Society
19 May 2023

“Chemoproteomic Identification of Blue-Light-Damaged
Proteins”
Division of Medicinal Chemistry, The Pharmaceutical Societyof Japan
20 June 2023

HAYASHI, Daiju

F

ARRAG,
Asmaa Mostafa Abdelbari Soliman

JSAP Poster AwardThe 70th JSAP Spring Meeting 2023

Excellent Poster Prize“Observation of Mode Splitting by Magnon-Magnon Couplingin Synthetic Antiferromagnets”

The 13th iCeMS Retreat

The Japan Society of Applied Physics

WPI-iCeMS, Kyoto University

Poster Award“Real-Time Monitoring of Biomolecular Condensates’ States”

10 May 2023

The 21st Annual Meeting of the Society of Nano Science andTechnology“Observation of Mode Splitting by Magnon-Magnon Couplingin Synthetic Antiferromagnets”
The Society of Nano Science and Technology
13 May 2023

29 September 2023

SATO, Hiroki
Poster Prize
The 2nd International Research Center Seminar on
Nanocarbon“Molecular-Level Analysis of Charge Traps in An Organic
Amorphous Film by Multiscale Simulation”
The Royal Society of Chemistry

KURIYAMA, Masashi

6 October 2023

Excellent Poster AwardInteractive Seminar on Novel Medicinal Chemistry for Young
Researchers (So-Yaku Konwa Kai)ARAKI, Taisuke“Identification of Biomolecules Involved in Intracellular
Delivery of Biopolymers”

Excellent Poster Award

Division of Medicinal Chemistry, The Pharmaceutical Societyof Japan
20 June 2023

The 46th Fluorine Conference of Japan“Understanding of Physical Properties of Perfluoroalkanes byInfrared Spectroscopy Using Recrystallized Compounds”
The Society of Fluorine Chemistry, Japan
25 October 2023

90

PERSONAL

SUGIMOTO, Emi

HIRA, Shota

Student Poster Award

Poster Award

The 52nd Japan Conference on Crystal Growth

The 33rd Symposium on Physical Organic Chemistry“Control of Crystal Orientation of Organic Semiconductors
with Alkyl Side Chains by Low-Temperature Deposition”“Hole-Collecting Monolayer Materials based on Squaraine
Structures for Perovskite Solar Cells”

The Japanese Association for Crystal Growth

The Society of Physical Organic Chemistry, Japan

25 December 2023

14 September 2023

HASEGAWA, Akio

IWASHIMIZU, Chisaki

Poster Award

Best Poster Award

The 50th Symposium. on Main Group Element Chemistry

Microscopy Conference 2023

“Synthesis of Metal Halides Derivatives bearing TriptycylGroups”“Different Image Contrasts between Atomic Resolution
HAADF and EELS Mapping in Rutile TiO2”

The Chemical Society of Japan (CSJ)

German Society for Electron Microscopy
2 March 2023

9 December 2023

HARATA, Fuyuki

MATSUOKA, Yuto

Poster PrizeBest Poster Presentation Award in 69th Symposium on
Organometallic Chemistry

The 5th Frontier Solar Cell Seminar“Development of Fabrication Method for Large-Area
Tin-Perovskite Thin Film”
The Executive Committee of the Frontier Solar Cell Seminar
15 December 2023

The 69th Symposium on Organometallic Chemistry, Japan“Difference in N2-Reducing Activity by [Mo3S4M] (M = Fe,
Co, Ni) Cubes”
Division of Organometallic Chemistry, The Kinki Chemical
Society
27 September 2023

ICR ANNUAL REPORT, 2023

91

PUBLICATIONSINTERNATIONAL   RESEARCH   COLLABORATIONSSELECTED GRANTS
THESES

PUBLICATIONSDIVISION OF SYNTHETIC CHEMISTRY— Organoelement Chemistry —Tajima, K.; Matsuo, K.; Yamada, H.; Fukui, N.; Shinokubo, H.,
Diazazethrene Bisimide: A Strongly Electron-Accepting π-System
Synthesized via the Incorporation of Both Imide Substituents andImine-Type Nitrogen Atoms into Zethrene, Chem. Sci., 14(3), 635642 (2023).
Hisa, T.; Kanno, Y.; Shirai, T.; Oshiki, T.; Mizuhata, Y.; Tokitoh,N.; Fukumoto, H.; Agou, T., Synthesis and Characterization of a
Polystyrene-Type Polymer Bearing a Cyclic Perfluoroalkylene
Group, Polymer, 265, 125588 (2023).
Nagatomo, T.; Vats, A. K.; Matsuo, K.; Oyama, S.; Okamoto, N.;
Suzuki, M.; Koganezawa, T.; Fuki, M.; Masuo, S.; Ohta, K.; Yamada,H.; Kobori, Y., Nonpolymer Organic Solar Cells: Microscopic
Phonon Control to Suppress Nonradiative Voltage Loss via ChargeSeparated State, ACS Phys. Chem. Au, 3(2), 207-221 (2023).
Suzuki, M.; Miura, M.; Ohkubo, E.; Karimata, H.; Aizawa, N.;
Yamada, H.; Nakayama, K., Possibilities and Limitations in
Monomer Combinations for Ternary Two-Dimensional Covalent
Organic Frameworks, J. Am. Chem. Soc., 145(5), 3008-3015 (2023).
Kurosaki, R.; Morimoto, H.; Matsuo, K.; Hayashi, H.; Yamada,H.; Aratani, N., An Atropisomerism Study of Large Cycloarylenes:[n]Cyclo-4,10-Pyrenylenes’ Case, Chem. Eur. J., 29(24), e202203848(2023).
Igarashi, H.; Yamauchi, M.; Masuo, S., Correlation between
Single-Photon Emission and Size of Cesium Lead Bromide
Perovskite Nanocrystals, J. Phys. Chem. A, 14(9), 2441-2447 (2023).
Lv, X.; Morimoto, H.; Liu, N.; Kuzuhara, D.; Aratani, N.;
Yamada, H.; Qiu, F.; Xue, S., Bent Dithienoporphyrin(2.1.2.1):
Synthesis, Structure, Optical and Electronic Properties, and Metal
Complexation, J. Org. Chem., 88(6), 3466-3473 (2023).
Duan, Y.; Chen, M.; Hayashi, H.; Yamada, H.; Liu, X.; Zhang, L.,
Buckybowl and Its Chiral Hybrids Featuring Eight-Membered
Rings and Helicene Units, Chem. Sci., 14(38), 10420-10428 (2023).
Mizuhata, Y.; Tokitoh, N., Germaaromatic Compounds,
Organogermanium Compounds: Theory, Experiment, andApplications, 477-506 (2023).
Lv, X.; Gao, H.; Wu, F.; Liu, N.; Ueno, S.; Yang, X.; Zhang, T.;
Aratani, N.; Yamada, H.; Qiu, F.; Shen, Z.; Xue, S., Highly Robustand Antiaromatic Rhenium(I) Rosarin, Inorg. Chem., 62(12), 47474751 (2023).
Kitao, T.; Miura, T.; Nakayama, R.; Tsutsui, Y.; Chan, Y. S.;
Hayashi, H.; Yamada, H.; Seki, S.; Hitosugi, T.; Uemura, T.,
Synthesis of Polyacene by Using a Metal-Organic Framework,
Nat. Synth., 2, 848-854 (2023).
Chiga, Y.; Takahata, R.; Suzuki, W.; Mizuhata, Y.; Tokitoh, N.;
Teranishi, T., Isomer-Selective Conversion of Au Clusters by
Au(I) Thiolate Insertion, Inorg. Chem., 62(26), 10049-10053(2023).

94

PUBLICATIONS

Iwai, K.; Mizuhata, Y.; Nakamura, T.; Goto, M.; Wakamiya, A.;
Shimakawa, Y.; Tokitoh, N., Solid-State Chromism of Zwitterionic
Triarylmethylium Salts, Eur. J. Inorg. Chem., 26(31), e202300337(2023).
Nishino, R.; Tokitoh, N.; Sasayama, R.; Waterman, R.; Mizuhata,Y., Unusual Nuclear Exchange within a Germanium-Containing
Aromatic Ring that Results in Germanium Atom Transfer, Nat.
Commun., 14, 4519 (2023).
Mizuhata, Y.; Ijichi, W.; Nishino, R.; Kato, T.; Kayahara, E.;
Yamago, S.; Tokitoh, N., Synthesis and Characterization of Novel
Hydrodigermenide and Digermyne Radical Anion, Polyhedron,
244, 116614 (2023).
Tanaka, H.; Mizuhata, Y.; Tokitoh, N.; Miyamoto, R.; Kanamori,K.; Kaji, H., Multiple Stimuli-Responsive Supramolecular Organic
Framework Under Concomitant Emission Color Changes, J.
Phys. Chem. C, 127(41), 20459-20465 (2023).
Yamada, H.; Matsuo, K., (Invited) 5,15-Diazatetrabenzoporphyrins:
Evaluation as Organic Semiconductors, ECS Meet. Abstr., MA202301, 1358, (2023).
Miyazaki, K.; Matsuo, K.; Hayashi, H.; Yamauchi, M.; Aratani,N.; Yamada, H., An Unsymmetrical 5,15-Disubstituted Tetrabenzoporphyrin: Effect of Molecular Symmetry on the Packing
Structure and Charge Transporting Property, Org. Lett., 25(40),7354-7358 (2023).
Yamauchi, M.; Nakatsukasa, K.; Kubo, N.; Yamada, H.; Masuo,
S., One-Dimensionally Arranged Quantum-Dot Superstructures
Guided by a Supramolecular Polymer Template, Angew. Chem.
Int. Ed., 63(1), e202314329 (2023).
Wakioka, M.; Hatakeyama, K.; Sakai, S.; Seki, T.; Tada, K. I.;
Mizuhata, Y.; Nakazato, T.; Koguchi, S.; Shibuya, Y.; Maruyama,Y.; Ayabe, M., Mixed-Ligand Approach to Palladium-Catalyzed
Direct Arylation of Heteroarenes with Aryl Chlorides: Controlling
Reactivity of Catalytic Intermediates via Dynamic Ligand Exchange,
Organometallics, 42(24), 3454-3465 (2023).
Fujimori, S.; Mizuhata, Y.; Tokitoh, N., Recent Progress in theChemistry of Heavy Aromatics, Proc. Jpn. Acad., Ser. B., 99(10),480-512 (2023).
Tsuji, S.; Tokitoh, N.; Yamada, H.; Mizuhata, Y., The Reductionof Metallabenzenes: Different Scenarios Highly Dependent on
the Central Group 14 Elements, Si vs. Ge, Chem. Asian J., 19(2),e202300945 (2023).
[Others]
Yamauchi, M.; Masuo, S., How to Arrange Quantum Dots?,
Monthly Chemistry, 78(2), 70-71 (2023).
— Structural Organic Chemistry —Hashikawa, Y.; Sadai, S.; Murata, Y., Bilateral π-Extension of an
Open-[60]Fullerene in a Helical Manner, Chem. Commun., 59,
6560-6563 (2023).

Hashikawa, Y.; Murata, Y., C2-Insertion into a Fullerene Orifice,Chem. Commun., 59(12), 1645-1648 (2023).
Sadai, S.; Hashikawa, Y.; Murata, Y., Open-[60]Fullerene-Aniline
Conjugates with Near-Infrared Absorption, RSC Adv., 13(21),14575-14579 (2023).
Hashikawa, Y.; Sadai, S.; Murata, Y., Synthesis of Open-[70]Fullerenes Bearing Huge Orifices, Chem. Commun., 59, 7387-7390(2023).
Briš, A.; Murata, Y.; Hashikawa, Y.; Margetić, D., Utilization of
Sym-Tetrazines as Guanidine Delivery Cycloaddition Reagents,
J. Mol. Struct., 1272, 134207 (2023).
Zhang, Z.; Murata, Y.; Hirose, T., Circularly Polarized Luminescenceof Hetero[n]Helicenes with 2,1,3-Thiadiazole Rings at BothEnds: Design of Magnetically-Allowed Electronic Transitions via
Heteroatom Embedding, Tetrahedron, 142, 133514 (2023).
Hashikawa, Y.; Sadai, S.; Okamoto, S.; Murata, Y., Near‐Infrared‐
Absorbing Chiral Open [60]Fullerenes, Angew. Chem. Int. Ed.,
62(2), e202215380 (2023).
Hashikawa, Y.; Sadai, S.; Murata, Y., Synthesis of Hydrogen‐
Bonded Open‐[60]Fullerenol Dimers, ChemPlusChem, 88(4),e202300136 (2023).
Sadai, S.; Hashikawa, Y.; Murata, Y., π-Extended Open-[70]Fullerenes with a Fused Azaacene, Org. Lett., 25(16), 2815-2819(2023).
Hashikawa, Y.; Sadai, S.; Murata, Y., Construction of a 21‐
Membered‐Ring Orifice on [60]Fullerene, ChemPlusChem, 88(9),e202300225 (2023).
Huang, G.; Ide, Y.; Hashikawa, Y.; Hirose, T.; Murata, Y.,
CH3CN@open‐C60: An Effective Inner‐Space Modification and
Isotope Effect Inside a Nano‐Sized Flask, Chem. Eur. J., 29(47),e202301161 (2023).
Hashikawa, Y.; Murata, Y., Water in Fullerenes, Bull. Chem. Soc.
Jpn., 96(9), 943-967 (2023).
— Synthetic Organic Chemistry —Sato, Y.; Miyamoto, Y.; Matsui, T.; Sumida, Y.; Ohmiya, H.,
Diastereoselective Congested β-Amido Ketone Synthesis via NHCCatalyzed Radical-Radical Coupling, Chem Catal., 3, 100736(2023).
Goto, Y.; Sano, M.; Sumida, Y.; Ohmiya, H., N-Heterocyclic
Carbene- and Organic Photoredox-Catalysed Meta-Selective
Acylation of Electron-Rich Arenes, Nat. Synth., 2, 1037-1045(2023).
Nakamura, R.; Yamazaki, T.; Kondo, Y.; Tsukada, M.; Miyamoto,Y.; Arakawa, N.; Sumida, Y.; Kiya, T.; Arai, S.; Ohmiya, H.,
Radical Caging Strategy for Cholinergic Optopharmacology, J.
Am. Chem. Soc., 145, 10651-10658 (2023).
Oya, R.; Ota, K.; Fuki, M.; Kobori, Y.; Higashi, M.; Nagao, K.;
Ohmiya, H., Biomimetic Design of an α-KetoacylphosphoniumBased Light-Activated Oxygenation Auxiliary, Chem. Sci., 14,10488-10493 (2023).

Ota, K.; Nagao, K.; Hata, D.; Sugiyama, H.; Segawa, Y.; Tokunoh,R.; Seki, T.; Miyamoto, N.; Sasaki, Y.; Ohmiya, H., Synthesis of
Tertiary Alkylphosphonate Oligonucleotides Through Light-Driven
Radical-Polar Crossover Reactions, Nat. Commun., 14, 6856 (2023).
— Advanced Inorganic Synthesis —Matsumoto, K.; Sato, R.; Teranishi, T., Stabilization of Unprecedented Crystal Phases of Metal Nanomaterials, Trends Chem.,
5(3), 201-213 (2023).
Kobiyama, E.; Tahara, H.; Saruyama, M.; Sato, R.; Teranishi, T.;
Kanemitsu, Y., Picosecond Trion Photocurrent Dynamics in
FAPbI3 Quantum Dot Films, Appl. Phys. Lett., 122(25), 252106(2023).
Cho, K.; Yamada, T.; Saruyama, M.; Sato, R.; Teranishi, T.;
Kanemitsu, Y., Temperature Dependence of Photoluminescence
Spectrum of Single Lead Halide Perovskite Nanocrystals: Effectof Size on the Phase Transition Temperature, J. Chem. Phys.,
158(20), 20114-1-201104-8 (2023).
Endo, K.; Saruyama, M.; Teranishi, T., Location-Selective
Immobilisation of Single-Atom Catalysts on the Surface or within
the Interior of Ionic Nanocrystals Using Coordination Chemistry,Nat. Commun., 14(1), 4241 (2023).
Gao, Y.; Uchiyama, T.; Yamamoto, K.; Watanabe, T.; Tominaka,S.; Thakur, N.; Sato, R.; Teranishi, T.; Imai, H.; Sakurai, Y.;
Uchimoto, Y., Origin of High Activity and Durability of Confined
Ordered Intermetallic PtCo Catalysts for the Oxygen Reduction
Reaction in Rotating Disk Electrode and Fuel Cell Operating
Conditions, ACS Catal., 13(16), 10988-11000 (2023).
Chiga, Y.; Takahata, R.; Suzuki, W.; Mizuhata, Y.; Tokitoh, N.;
Teranishi, T., Isomer-Selective Conversion of Au Clusters by
Au(I) Thiolate Insertion, Inorg. Chem., 62(26), 10049-10053 (2023).
Gao, Y.; Uchiyama, T.; Yamamoto, K.; Watanabe, T.; Thakur,
N.; Sato, R.; Teranishi, T.; Imai, H.; Sakurai, Y.; Uchimoto, Y.,
Protection Against Absorption Passivation on Platinum by a
Nitrogen-Doped Carbon Shell for Enhanced Oxygen Reduction
Reaction, ACS Appl. Mater. Interfaces, 15(25), 30240-30248(2023).
DIVISION OF MATERIALS CHEMISTRY— Chemistry of Polymer Materials —Inoue, Y.; Kim, Y.; Hasegawa, H.; Yoshida, Y.; Sakakibara, K.;
Tsujii, Y., A Novel Electrochemical Biosensing Method with
Double-Layered Polymer Brush Modified Electrode, Colloids
Surf. B, 222, 113105 (2023).
Ishida, K.; Kondo, T., Anisotropic Frictional Properties Induced
by Cellulose Nanofibril Assembly, Biomacromolecules, 24(7),3009-3015 (2023).
Sakakibara, K.; Tsujii, Y., Visualization of Fibrillated Cellulose in
Polymer Composites Using a Fluorescent-Labeled Polymer
Dispersant, ACS Sustain. Chem. Eng., 11(16), 6332-6342 (2023).
Ishida, K.; Kondo, T., Evaluation of Surface Free Energy Inducing Interfacial Adhesion of Amphiphilic Cellulose Nanofibrils,
Biomacromolecules, 24(8), 3786-3793 (2023).

Takekawa, Y.; Nakagawa, M.; Nagao, K.; Ohmiya, H., A Quadruple
Catalysis Enabling Intermolecular Branch-Selective Hydroacylation of Styrenes, Chem. Eur. J., 29, e202301484 (2023).

ICR ANNUAL REPORT, 2023

95

Okubo, H.; Kagiwata, D.; Sasaki, S.; Tsujii, Y.; Nakano, K.,
Operando Tribo-Raman Spectroscopic Observation for Wear
Processes of Superlow Frictional Concentrated Polymer Brushes
at Frictional Interface, Polym. Test., 127, 108170 (2023).
Nakanishi, Y.; Ishige, R.; Ogawa, H.; Huang, Y.; Sakakibara, K.;
Ohno, K.; Kanaya, T.; Takenaka, M.; Tsujii, Y., Unified Explanation for Self-Assembly of Polymer-Brush-Modified Nanoparticles in Ionic Liquids, Polym. J., 55, 1199-1209 (2023).
— Polymer Controlled Synthesis —Chen, D.; Wada, Y.; Kusakabe, Y.; Sun, L.; Kayahara, E.; Suzuki,
K.; Tanaka, H.; Yamago, S.; Kaji, H.; Zysman-Colman, E., A
Donor–Acceptor 10-Cycloparaphenylene and Its Use as an
Emitter in an Organic Light-Emitting Diode, Org. Lett., 25(6),998-1002 (2023).
Mizuhata, Y.; Ijichi, W.; Nishino, R.; Kato, T.; Kayahara, E.;
Yamago, S.; Tokitoh, N., Synthesis and Characterization of Novel
Hydrodigermenide and Digermyne Radical Anion, Polyhedron,
244, 116614 (2023).
Miyazawa, Y.; Wang, Z.; Hatano, S.; Takagi, R.; Matsuoka, H.;
Amamizu, N.; Kitagawa, Y.; Kayahara, E.; Yamago, S.; Abe, M.,
Generation and Characterization of a Tetraradical Embedded
in a Curved Cyclic Paraphenylene Unit, Chem. Eur. J., 29(42),e202301009 (2023).
Jiang, Y.; Kibune, M.; Tosaka, M.; Yamago, S., Practical Synthesisof Dendritic Hyperbranched Polyacrylates and Their Topological
Block Polymers by Organotellurium‐Mediated Emulsion Polymerization in Water, Angew. Chem. Int. Ed., 62(35), e202306916(2023).
Tosaka, M.; Takeuchi, H.; Kibune, M.; Tong, T.; Zhu, N.; Yamago,S., Stochastic Simulation of Controlled Radical Polymerization
Forming Dendritic Hyperbranched Polymers, Angew. Chem. Int.
Ed., 62(29), e202305127 (2023).
Terabayashi, T.; Kayahara, E.; Zhang, Y.; Mizuhata, Y.; Tokitoh,
N.; Nishinaga, T.; Kato, T.; Yamago, S., Synthesis of Twisted [n]Cycloparaphenylene by Alkene Insertion, Angew. Chem. Int. Ed.,
62(2), e202214960 (2023).

Haruyama, M.; Kato, H.; Ogura, M.; Kato, Y.; Takeuchi, D.;
Yamasaki, S.; Iwasaki, T.; Morishita, H.; Fujiwara, M.; Mizuochi,
N.; Makino, T., Electroluminescence of Negatively Charged
Single NV Centers in Diamond, Appl. Phys. Lett., 122(7), 72101(2023).
Fujiwara, M.; Inoue, S.; Masuno, S.; Fu, H.; Tokita, S.; Hashida,M.; Mizuochi, N., Creation of NV Centers over a MillimeterSized Region by Intense Single-Shot Ultrashort Laser Irradiation,
APL Photonics, 8(3), 036108 (2023).
Morishita, H.; Morioka, N.; Nishikawa, T.; Yao, H.; Onoda, S.;
Abe, H.; Ohshima, T.; Mizuochi, N., Spin-Dependent Dynamics
of Photocarrier Generation in Electrically Detected NitrogenVacancy-Based Quantum Sensing, Phys. Rev. Appl., 19(3), 34061(2023).
Deguchi, H.; Hayashi, T.; Saito, H.; Nishibayashi, Y.; Teramoto,M.; Fujiwara, M.; Morishita, H.; Mizuochi, N.; Tatsumi, N.,
Compact and Portable Quantum Sensor Module Using Diamond
NV Centers, Appl. Phys. Express, 16(6), 62004 (2023).
Shimizu, M.; Makino, T.; Kato, H.; Fujiwara, M.; Ogura, M.;
Mizuochi, N.; Hatano, M., Charge States of Nitrogen-Vacancy
Centers in Fermi Level Controlled Diamond n-i-n Junctions, J.
Appl. Phys., 133(21), 214401 (2023).
Geng, J.; Shalomayeva, T.; Gryzlova, M.; Mukherjee, A.;
Santonocito, S.; Dzhavadzade, D.; Dasari, D.; Kato, H.; Stöhr, R.;
Denisenko, A.; Mizuochi, N.; Wrachtrup, J., Dopant-Assisted
Stabilization of Negatively Charged Single Nitrogen-Vacancy
Centers in Phosphorus-Doped Diamond at Low Temperatures,
npj Quantum Inf., 9, 110 (2023).
Fujiwara, M.; Fu, H.; Hariki, N.; Ohki, I.; Makino, Y.; Liu,
M.; Tsurui, A.; Yoshikawa, T.; Nishikawa, M.; Mizuochi, N.,
Germanium-Vacancy Centers in Detonation Nanodiamond for
All-Optical Nanoscale Thermometry, Appl. Phys. Lett., 123, 181903(2023).
Kinouchi, K.; Shimotsuma, Y.; Uemoto, M.; Fujiwara, M.;
Mizuochi, N.; Shimizu, M.; Miura, K., Laser Writing of Preferentially Orientated Nitrogen-Vacancy Centers in Diamond, Carbon
Trends, 13, 100318 (2023).

[Others]— Nanospintronics —Yamago, S., History Repeats Itself: The Transition from Organic
Synthesis to Macromolecular Synthesis, Dramatic Synthetic Organic
Chemistry: A Circle of Inspiration 100, The Society of Synthetic
Organic Chemistry, Japan, Ed., Kagakudojin, 130-131 (2023).

Kawarazaki, R.; Iijima, R.; Narita, H.; Hisatomi, R.; Shiota, Y.;
Moriyama, T.; Ono, T., Rectification Effect of Non-Centrosymmetric
Nb/V/Ta Superconductor, J. Magn. Soc., 47(5), 133-136 (2023).

Yamago, S.; Jiang, Y., Practical Synthesis of Structure-Controlled
Hyperbranched Polymers by Radical Polymerization, Kobunshi,
72, 463-467 (2023).
— Inorganic Photonics Materials —Tabuchi, H.; Matsuzaki, Y.; Furuya, N.; Nakano, Y.; Watanabe,
H.; Tokuda, N.; Mizuochi, N.; Ishi-Hayase, J., Temperature
Sensing with RF-Dressed States of Nitrogen-Vacancy Centers inDiamond, J. Appl. Phys., 133(2), 24401 (2023).
Shimotsuma, Y.; Kinouchi, K.; Yanoshita, R.; Fujiwara, M.;
Mizuochi, N.; Uemoto, M.; Shimizu, M.; Miura, K., Formation of
NV Centers in Diamond by a Femtosecond Laser Single Pulse,
Opt. Express, 31(2), 1594-1603 (2023).

96

PUBLICATIONS

Ham, W. S.; Ho, T. H.; Shiota, Y.; Iino, T.; Ando, F.; Ikebuchi, T.;
Kotani, Y.; Nakamura, T.; Kan, D.; Shimakawa, Y.; Moriyma, T.;
Im, E.; Lee, N. J.; Kim, K. W.; Hong, S. C.; Rhim, S. H.; Ono, T.;
Kim, S., Bulk Rashba‐Type Spin Splitting in Non‐Centrosymmetric
Artificial Superlattices, Adv. Sci., 10(12), 2206800 (2023).
Tanaka, M.; Furuta, M.; Ichikawa, T.; Morishita, M.; Hung,
Y.-M.; Honda, S.; Ono, T.; Mibu, K., Generation of SpinPolarized Electronic Currents Using Perpendicularly Magnetized
Cobalt Ferrite Spin-Filtering Barriers Grown on Spinel-TypeConductive Layers, Appl. Phys. Lett., 122, 42401 (2023).
Funada, S.; Ishikawa, Y.; Kimata, M.; Hayashi, K.; Sano, T.;
Sugi, K.; Fujii, Y.; Mitsudo, S.; Shiota, Y.; Ono, T.; Moriyama, T.,Electrical Detection of Antiferromagnetic Dynamics in Gd-Co
Thin Films Using 154-GHz Gyrotron Irradiation, Phys. Rev.
Appl., 19(3), L031003 (2023).

Kobayashi, Y.; Shiota, Y.; Narita, H.; Ono, T.; Moriyama, T.,
Pulse-Width Dependence of Spin–Orbit Torque Switching in
Mn3Sn/Pt Thin Films, Appl. Phys. Lett., 122(12), 122405 (2023).
Hisatomi, R.; Taga, K.; Sasaki, R.; Shiota, Y.; Moriyama, T.; Ono,
T., Quantitative Optical Imaging Method for Surface Acoustic
Waves Using Optical Path Modulation, Phys. Rev. B, 107, 165416(2023).
Hayashi, D.; Shiota, Y.; Ishibashi, M.; Hisatomi, R.; Moriyama,T.; Ono, T., Observation of Mode Splitting by Magnon–Magnon
Coupling in Synthetic Antiferromagnets, Appl. Phys. Express, 16,53004 (2023).

Hirose, H.; Nakata, E.; Zhang, Z.; Shibano, Y.; Maekawa, M.;
Morii, T.; Futaki, S., Macropinoscope: Real-Time Simultaneous
Tracking of pH and Cathepsin B Activity in Individual Macropinosomes, Anal. Chem., 95(30), 11410-11419 (2023).
Tanaka, K.; Suda, A.; Uesugi, M.; Futaki, S.; Imanishi, M., Xanthine Derivatives Inhibit FTO in an l-Ascorbic Acid-Dependent
Manner, Chem. Commun., 59(72), 10809-10812 (2023).
Omura, M.; Morimoto, K.; Araki, Y.; Hirose, H.; Kawaguchi, Y.;
Kitayama, Y.; Goto, Y.; Harada, A.; Fujii, I.; Takatani-Nakase, T.;
Futaki, S.; Nakase, I., Inkjet-Based Intracellular Delivery Systemthat Effectively Utilizes Cell-Penetrating Peptides for Cytosolic
Introduction of Biomacromolecules through the Cell Membrane,
ACS Appl. Mater. Interfaces, 15(41), 47855-47865 (2023).

Moriyama, T.; Sanchez-Tejerina, L.; Oda, K.; Ohkochi, T.;
Kimata, M.; Shiota, Y.; Nojiri, H.; Finocchio, G.; Ono, T.,
Micromagnetic Understanding of Evolutions of Antiferromagnetic Domains in NiO, Phys. Rev. Mater., 7(5), 54401 (2023).

— Chemistry of Molecular Biocatalysts —Ryu, J.; Avci, C. O.; Song, M.; Huang, M.; Thompson, R.; Yang,J.; Ko, S.; Karube, S.; Tezuka, N.; Kohda, M.; Kim, K.-J.; Beach,
G. S. D.; Nitta, J., Deterministic Current‐Induced Perpendicular
Switching in Epitaxial Co/Pt Layers without an External Field,
Adv. Funct. Mater., 33, 2209693 (2023).

Okabe, S.; Kitaoka, K.; Suzuki, T.; Kuruma, M.; Hagihara, S.;
Yamaguchi, S.; Fukui, K.; Seto, Y., Desmethyl Type Germinone,a Specific Agonist for the HTL/KAI2 Receptor, Induces the
Arabidopsis Seed Germination in a Gibberellin-Independent
Manner, Biochem. Biophys. Res. Commun., 649, 110-117 (2023).

Narita, H.; Ishizuka, J.; Kan, D.; Shimakawa, Y.; Yanase, Y.;
Ono, T., Magnetization Control of Zero‐Field Intrinsic Superconducting Diode Effect, Adv. Mater., 35, 2304083 (2023).

Mashiguchi, K.; Morita, R.; Tanaka, K.; Kodama, K.; Kameoka,
H.; Kyozuka, J.; Seto, Y.; Yamaguchi, S., Activation of Strigolactone Biosynthesis by the DWARF14-LIKE/KARRIKININSENSITIVE2 Pathway in Mycorrhizal Angiosperms, but Not
in Arabidopsis, a Non-Mycorrhizal Plant, Plant Cell Physiol.,64(9), 1066-1078 (2023).

Stebliy, M. E.; Bazrov, M. A.; Namsaraev, Z. Zh.; Letushev, M.
E.; Kozlov, A. G.; Antonov, V. A.; Stebliy, E. V.; Davydenko, A.
V.; Ognev, A. V.; Shiota, Y.; Ono, T.; Samardak, A. S., Nonuniform
Current-Driven Formation and Displacement of the Magnetic
Compensation Point in Variable-Width Nanoscale Ferrimagnets,
ACS Appl. Mater. Interfaces, 15(34), 40792-40798 (2023).
Sugi, K.; Ishikawa, T.; Kimata, M.; Shiota, Y.; Ono, T.; Kato, T.;
Moriyama, T., Spin Hall Magnetoresistive Detection of Easy-Plane
Magnetic Order in the Van der Waals Antiferromagnet NiPS3,
Phys. Rev. B, 108, 64434 (2023).
DIVISION OF BIOCHEMISTRY— Biofunctional Design-Chemistry —Ida, H.; Taira, N.; Azuma, K.; Kumatani, A.; Akishiba, M.; Futaki,S.; Takahashi, Y.; Shiku, H., Surface Morphology Live-Cell
Imaging Reveals How Macropinocytosis Inhibitors AffectMembrane Dynamics, Electrochim. Acta, 441, 141783 (2023).
Negi, S.; Imanishi, M.; Hamori, M.; Kawahara-Nakagawa, Y.;
Nomura, W.; Kishi, K.; Shibata, N.; Sugiura, Y., The Past, Present,
and Future of Artificial Zinc Finger Proteins: Design Strategies
and Chemical and Biological Applications, J. Biol. Inorg. Chem.,
28(3), 249-261 (2023).
Xu, W.; Kadoya, Y.; Sennari, K.; Islam, W.; Zhang, T.; Sawa, T.;
Akizuki, F.; Hirose, H.; Futaki, S.; Fujiwara, Y.; Komohara, Y.;
Niidome, T., Disulfiram Encapsulated in Polymer Nanoparticles
Ameliorates Thioacetamide-Induced Liver Injury, J. Drug
Delivery Sci. Technol., 88, 104981 (2023).
Nishimura, M.; Kawaguchi, Y.; Kuroki, K.; Nakagawa, Y.;
Masuda, T.; Sakai, T.; Kawano, K.; Hirose, H.; Imanishi, M.;
Takatani-Nakase, T.; Afonin, S.; Ulrich, A.S.; Futaki, S., Structural
Dissection of Epsin‐1 N‐Terminal Helical Peptide: The Role of
Hydrophobic Residues in Modulating Membrane Curvature,
Chem. Eur. J., 29(29), e202300129 (2023).

Sun, R.; Okabe, M.; Miyazaki, S.; Ishida, T.; Mashiguchi, K.;
Inoue, K.; Yoshitake, Y.; Yamaoka, S.; Nishihama, R.; Kawaide,
H.; Nakajima, M.; Yamaguchi, S.; Kohchi, T., Biosynthesis ofGibberellin-Related Compounds Modulates Far-Red Light
Responses in the Liverwort Marchantia polymorpha, Plant Cell,
35(11), 4111-4132 (2023).
Cui, J.; Nishide, N.; Mashiguchi, K.; Kuroha, K.; Miya, M.;
Sugimoto, K.; Itoh, J.-I.; Yamaguchi, S.; Izawa, T., Fertilization
Controls Tiller Numbers via Transcriptional Regulation of a MAX1like Gene in Rice Cultivation, Nat. Commun., 14(1), 3191 (2023).
Kameoka, H.; Shimazaki, S.; Mashiguchi, K.; Watanabe, B.;
Komatsu, A.; Yoda, A.; Mizuno, Y.; Kodama, K.; Okamoto, M.;
Nomura, T.; Yamaguchi, S.; Kyozuka, J., DIENELACTONEHYDROLASE LIKE PROTEIN1 Negatively Regulates the KAI2Ligand Pathway in Marchantia polymorpha, Curr. Biol., 33(16),3505-3513 (2023).
— Molecular Biology —Akagi, C.; Kurihara, Y.; Makita, Y.; Kawauchi, M.; Tsuge, T.;
Aoyama, T., Translational Activation of Ribosome-Related Genesat Initial Photoreception Is Dependent on Signals Derived from
Both the Nucleus and the Chloroplasts in Arabidopsis thaliana, J.
Plant Res., 136(2), 227-238 (2023).
— Chemical Biology —Kawagoe, F.; Mototani, S.; Mendoza, A.; Takemoto, Y.; Uesugi,
M.; Kittaka, A., Structure–Activity Relationship Studies on
Vitamin D-Based Selective SREBP/SCAP Inhibitor KK-052,
RSC med. chem., 14(10), 2030-2034 (2023).

ICR ANNUAL REPORT, 2023

97

Tanaka, K.; Suda, A.; Uesugi, M.; Futaki, S.; Imanishi, M., Xanthine
Derivatives Inhibit FTO in an l-Ascorbic Acid-Dependent Manner,
Chem. Commun., 59(72), 10809-10812 (2023).
Perron, A.; Mandal, S.; Chuba, T. N.; Mao, D.; Singh, V. P.; Noda,
N.; Tan, R.; Vu, H. T.; Abo, M.; Uesugi, M., Small-Molecule
Drug Repurposing for Counteracting Phototoxic A2E Aggregation,
ACS Chem. Biol., 18(10), 2170-2175 (2023).
Zhuo, S.-H.; Noda, N.; Hioki, K.; Jin, S.; Hayashi, T.; Hiraga, K.;
Momose, H.; Li, W.-H.; Zhao, L.; Mizukami, T.; Ishii, K. J.; Li,
Y.-M.; Uesugi, M., Identification of a Self-Assembling SmallMolecule Cancer Vaccine Adjuvant with an Improved Toxicity
Profile, J. Med. Chem., 66(18), 13266-13279 (2023).
DIVISION OF ENVIROMENTAL CHEMISTRY— Molecular Materials Chemistry —Nagamura, N.; Sasabe, H.; Sato, H.; Ito, N.; Abe, S.; Sukegawa,Y.; Yokoyama, D.; Kaji, H.; Kido, J., Robust Spirobifluorene Core
Based Hole Transporters with High Mobility for Long‐Life Green
Phosphorescent Organic Light‐Emitting Devices, Chem. Eur. J.,
29(1), e202202636-1-e202202636-8 (2023).
Ando, H.; Suzuki, K.; Kaji, H.; Kambe, T.; Nishina, Y.; Nakano,C.; Gotoh, K., Dynamic Nuclear Polarization – Nuclear Magnetic
Resonance for Analyzing Surface Functional Groups on Carbonaceous Materials, Carbon, 206(25), 84-93 (2023).
Shizu, K.; Ren, Y.; Kaji, H., Promoting Reverse Intersystem
Crossing in Thermally Activated Delayed Fluorescence via the
Heavy-Atom Effect, J. Phys. Chem. A, 127(2), 439-449 (2023).
Miranda-Salinas, H.; Rodriguez-Serrano, A.; Kaminski, J. M.;
Dinkelbach, F.; Hiromichi, N.; Kusakabe, Y.; Kaji, H.; Marian, C.
M.; Monkman, A. P., Conformational, Host, and Vibrational
Effects Giving Rise to Dynamic TADF Behavior in the ThroughSpace Charge Transfer, Triptycene Bridged Acridine-Triazine
Donor Acceptor TADF Molecule TpAT-tFFO, J. Phys. Chem. C,
127(18), 8607-8617 (2023).
Tanaka, H.; Mizuhata, Y.; Tokitoh, N.; Miyamoto, R.; Kanamori,K.; Kaji, H., Multiple Stimuli-Responsive Supramolecular Organic
Framework under Concomitant Emission Color Changes, J. Phys.
Chem. C, 127(41), 20459-20465 (2023).
Chen, D.; Wada, Y.; Kusakabe, Y.; Sun, L.; Kayahara, E.; Suzuki,
K.; Tanaka, H.; Yamago, S.; Kaji, H.; Zysman-Colman, E., A
Donor-Acceptor 10-Cycloparaphenylene and Its Use as an Emitterin an Organic Light-Emitting Diode, Org. Lett., 25(6), 998-1002(2023).
Suzuki, K.; Kaji, H., Torsion Angle Analysis of a Thermally
Activated Delayed Fluorescence Emitter in an Amorphous State
Using Dynamic Nuclear Polarization Enhanced Solid-State
NMR, J. Am. Chem. Soc., 145(30), 16324-16329 (2023).
Madushani, B.; Mamada, M.; Goushi, K.; Nguyen, T. B.;
Nakanotani, H.; Kaji, H.; Adachi, C., Multiple Donor–Acceptor
Design for Highly Luminescent and Stable Thermally Activated
Delayed Fluorescence Emitters, Sci. Rep., 13, 7644-1-7644-8 (2023).
Yumoto, S.; Katsumata, J.; Osawa, F.; Wada, Y.; Suzuki, K.; Kaji,H.; Marumoto, K., Operando ESR Observation in Thermally
Activated Delayed Fluorescent Organic Light-Emitting Diodes,
Sci. Rep., 13, 11109-1 (2023).

98

PUBLICATIONS

Tsuji, Y.; Kanno, N.; Goto, C.; Katao, S.; Okajima, Y.; Reine, P.;
Imbrasas, P.; Reineke, S.; Shizu, K.; Nakashima, T.; Kaji, H.;
Kawai, T.; Louis, M., A Binaphthalimide Motif as a Chiral Scaffold
for Thermally Activated Delayed Fluorescence with Circularly
Polarized Luminescence Activity, J. Mater. Chem. C, 11(18), 59685978 (2023).
Kanno, N.; Ren, Y.; Kusakabe, Y.; Suzuki, K.; Shizu, K.; Tanaka,
H.; Wada, Y.; Nakagawa, H.; Geldsetzer, J.; Kaji, H., ThioxanthoneContaining Blue Thermally Activated Delayed Fluorescent
Emitter, Appl. Phys. Express, 16(1), 011006-1-011006-4 (2023).
[Others]
Sato, H.; Kanda, S.; Kaji, H., Molecular-Level Analysis of Charge
Traps in an Organic Amorphous Film by Multiscale Simulation,
The 84th The Japan Society of Applied Physics Autumn Meeting
2023, TKP Kumamoto Conference Center (2023).
Shizu, K.; Kaji, H., Accelerating Reverse Intersystem Crossing in
Thermally Activated Delayed Fluorescence via the Heavy-AtomEffect, International Congress on Pure & Applied Chemistry(ICPAC) Bali 2023, The Patra Bali Resort & Villas (2023).
Tanaka, H.; Mizuhata, Y.; Tokitoh, N.; Miyamoto, R.; Kanamori,K.; Kaji, H., Stimuli-Responsive Supramolecular Organic Framework involving Reversible Fluorochromic Behaviors, Annual
Meeting on Photochemistry 2023, International ConferenceCenter Hiroshima (2023).
Shizu, K.; Kaji, H., Theoretical Understanding of Multiple Resonance Thermally Activated Delayed Fluorescence Mechanism,
Society of Computer Chemistry, Japan, 2023 Spring Meeting,
Ookayama Campus, Tokyo Institute of Technology (2023).
Suzuki, K.; Kaji, H., Structural and Dynamics Analysis of Organic
Semiconducting Materials by Solid State NMR, The 243rd ECS
Meeting, Hynes Convention Center (2023).
Shizu, K.; Kaji, H., Theoretical Understanding of Multiple
Resonance Thermally Activated Delayed Fluorescence, The
103th CSJ Annual Meeting (2024), Noda Campus, Tokyo Universityof Science (2023).
Kanno, N.; Ren, Y.; Kusakabe, Y.; Suzuki, K.; Shizu, K.; Wada,Y.; Geldsetzer, J.; Kaji, H., Thioxanthone-Based Novel Blue
Thermally Activated Delayed Fluorescence Emitter, The 70th
The Japan Society of Applied Physics Spring Meeting 2023,
Yotsuya Campus Sophia University + Online (2023).
Shizu, K.; Ren, Y.; Kaji, H., Accelerating Reverse Intersystem
Crossing in Thermally Activated Delayed Fluorescence via HeavyAtom Effect, The 70th The Japan Society of Applied Physics
Spring Meeting 2023, Yotsuya Campus Sophia University + Online(2023).
Sato, H.; Kanda, S.; Kaji, H., Analysis of Charge Traps in Organic
Amorphous Film by Multiscale Simulation, The 70th The Japan
Society of Applied Physics Spring Meeting 2023, Yotsuya Campus
Sophia University + Online (2023).
Sato, H.; Kanda, S.; Kaji, H., Molecular-Level Analysis of Charge
Traps in an Organic Amorphous Film by Multiscale Simulation,
The 2nd Seminar on International Core-to-Core Project on Nano
Carbon Device Science at Kyoto (2023).

— Hydrospheric Environment Analytical Chemistry —Iwase, M.; Isobe, K.; Zheng, L.; Takano, S.; Sohrin, Y., SolidPhase Extraction of Palladium, Platinum, and Gold from Water
Samples: Comparison between a Chelating Resin and a Chelating
Fiber with Ethylenediamine Groups, Anal. Sci., 39(5), 695-704(2023).
Alam, M.; Muguli, T.; Gurumurthy, G. P.; Arif, M.; Sohrin, Y.;
Singh, A. D.; Radhakrishna, T.; Pandey, D. K.; Verma, K.,
Hydroclimatic Conditions and Sediment Provenance in the
Northeastern Arabian Sea since the Late Miocene: Insights from
Geochemical and Environmental Magnetic Records at IODP Site
U1457 of the Laxmi Basin, Geol. Mag., 160(4), 813-829 (2023).
Sieber, M.; Lanning, N. T.; Bian, X.; Yang, S.-C.; Takano, S.;
Sohrin, Y.; Weber, T. S.; Fitzsimmons, J. N.; John, S. G.; Conway,
T. M., The Importance of Reversible Scavenging for the
Marine Zn Cycle Evidenced by the Distribution of Zinc and Its
Isotopes in the Pacific Ocean, J. Geophys. Res.: Oceans, 128(4),e2022JC019419 (2023).
Matsuoka, K.; Tatsuyama, T.; Takano, S.; Sohrin, Y., Distributionof Stable Isotopes of Mo and W from a River to the Ocean: Signatures of Anthropogenic Pollution, Front. Mar. Sci., 10 (2023).
Ueki, R.; Zheng, L.; Takano, S.; Sohrin, Y., Distributions ofZirconium, Niobium, Hafnium, and Tantalum in the Subarctic
North Pacific Ocean Revisited with a Refined Analytical Method,
Geochem. J., 57(5), 143-154 (2023).
— Chemistry for Functionalized Surfaces —Takahashi, H.; Yasui, T.; Hirano, M.; Shinjo, K.; Miyazaki, Y.;
Shinoda, W.; Hasegawa, T.; Natsume, A.; Kitano, Y.; Ida, M.;
Zhang, M.; Shimada, T.; Paisrisarn, P.; Zhu, Z.; Ohka, F.; Aoki,
K.; Rahong, S.; Nagashima, K.; Yanagida, T.; Baba, Y., Mutation
Detection of Urinary Cell-Free DNA via Catch-and-Release
Isolation on Nanowires for Liquid Biopsy, Biosens. Bioelectron.,
234, 115318 (2023).
Hu, S.; Zhao, P.; Nakano, K.; Oliver, R. D. J.; Pascual, J.;
Smith, J. A.; Yamada, T.; Truong, M. A.; Murdey, R.; Shioya, N.;
Hasegawa, T.; Ehara, M.; Johnston, M. B.; Tajima, K.; Kanemitsu,
Y.; Snaith, H. J.; Wakamiya, A., Synergistic Surface Modificationof Tin–Lead Perovskite Solar Cells, Adv. Mater., 35(9), 2208320(2023).
Truong, M. A.; Funasaki, T.; Ueberricke, L.; Nojo, W.; Murdey,
R.; Yamada, T.; Hu, S.; Akatsuka, A.; Sekiguchi, N.; Hira, S.; Xie,
L.; Nakamura, T.; Shioya, N.; Kan, D.; Tsuji, Y.; Iikubo, S.;
Yoshida, H.; Shimakawa, Y.; Hasegawa, T.; Kanemitsu, Y.;
Kanemitsu, Y.; Suzuki, T.; Wakamiya, A., Tripodal Triazatruxene
Derivative as a Face-On Oriented Hole-Collecting Monolayer for
Efficient and Stable Inverted Perovskite Solar Cells, J. Am. Chem.
Soc., 145(13), 7528-7539 (2023).
Oka, T.; Shioya, N.; Shimoaka, T.; Hasegawa, T., Structural
Rearrangement of Organic Semiconductor Molecules with an
Asymmetric Shape in Thin Films, J. Phys. Chem. C, 127(15),7560-7564 (2023).
Kitano, S.; Tanabe, I.; Shioya, N.; Hasegawa, T.; Murata, T.;
Morita, Y.; Tsuji, R.; Fukui, K., Voltammetric and In Situ Spectroscopic Investigations on the Redox Processes of Trioxotriangulene Neutral Radicals on Graphite Electrodes, Langmuir, 39(19),6846-6854 (2023).

Shimoaka, T.; Yamaguchi, Y.; Shioya, N.; Ajayaghosh, A.; Mori,T.; Ariga, K.; Hasegawa, T., Insights on the Molecular Orientationof Oligo(p-Phenylene Vinylene) Derivatives with Alkyl Chains inLangmuir Films, J. Phys. Chem. C, 127(19), 9336-9343 (2023).
Yokoi, A.; Ukai, M.; Yasui, T.; Inokuma, Y.; Hyeon-Deuk, K.;
Matsuzaki, J.; Yoshida, K.; Kitagawa, M.; Chattrairat, K.; Iida, M.;
Shimada, T.; Manabe, Y.; Chang, I.-Y.; Asano-Inami, E.; Koya,
Y.; Nawa, A.; Nakamura, K.; Kiyono, T.; Kato, T.; Hirakawa, A.;
Yoshioka, Y.; Ochiya, T.; Hasegawa, T.; Baba, Y.; Yamamoto, Y.;
Kajiyama, H., Identifying High-Grade Serous Ovarian CarcinomaSpecific Extracellular Vesicles by Polyketone-Coated Nanowires,
Sci. Adv., 9(27), eade6958 (2023).
Kitao, T.; Legrand, A.; Mori, T.; Ariga, K.; Uemura, T., Preferential
Orientation of Anisotropic Polythiophene Rods toward Macroscopic Chain Ordering, Mol. Syst. Des. Eng., 8(3), 316-322 (2023).
Akine, S.; Nomura, K.; Takahashi, M.; Sakata, Y.; Mori, T.;
Nakanishi, W.; Ariga, K., Synthesis of Amphiphilic Chiral Salen
Complexes and Their Conformational Manipulation at the AirWater Interface, Dalton Trans., 52(2), 260-268 (2023).
[Others]
Shioya, N., Hidden Thin-Film Phase of Organic Semiconductor,
MEMBRANE, 48(4), 160-162 (2023).
— Molecular Microbial Science —Kawano, K.; Kamasaka, K.; Yokoyama, F.; Kawamoto, J.; Ogawa,
T.; Kurihara, T.; Matsuzaki, K., Structural Factors Governing
Binding of Curvature-Sensing Peptides to Bacterial Extracellular
Vesicles Covered with Hydrophilic Polysaccharide Chains, Biophys.
Chem., 299, 107039 (2023).
Mullane, K. K.; Nishiyama, M.; Kurihara, T.; Bartlett, D. H.,
Compounding Deep Sea Physical Impacts on Marine Microbial
Motility, Front. Mar. Sci., 10 (2023).
DIVISION OF MULTIDISCIPLINARY CHEMISTRY― Polymer Materials Science ―Asai, H.; Shibata, M.; Takenaka, M.; Takata, S.; Hiroi, K.; Ouchi,
M.; Terashima, T., Micelle‐Crosslinked Hydrogels with Stretchable,
Self‐Healing, and Selectively Adhesive Properties: Random Copolymers Work as Dynamic yet Self‐Sorting Domains, Aggregate,
4(3), e316 (2023).
Huang, Z.; Bajaj, Y.; Carrillo, J.-M. Y.; Nakanishi, Y.; Uchida, K.;
Mita, K.; Yamada, T.; Miyazaki, T.; Sumpter, B. G.; Endoh, M.;
Koga, T., Local Conformations and Heterogeneities in Structures
and Dynamics of Isotactic Polypropylene Adsorbed onto Carbon
Fiber, Polymer, 265, 125584 (2023).
Nakanishi, Y.; Ishige, R.; Ogawa, H.; Huang, Y.; Sakakibara, K.;
Ohno, K.; Kanaya, T.; Takenaka, M.; Tsujii, Y., Unified Explanation for Self-Assembly of Polymer-Brush-Modified Nanoparticles
in Ionic Liquids, Polym. J., 55, 1199-1209 (2023).
Watanabe, Y.; Ogawa, H.; Konishi, T.; Nishitsuji, S.; Ono, S.;
Shimizu, N.; Takenaka, M., Distribution of Oriented Lamellar
Structures in Injection-Molded High-Density Polyethylene
Visualized via the Small Angle X-Ray Scattering-Computed
Tomography Method, Macromolecules, 56(15), 5964-5973 (2023).

ICR ANNUAL REPORT, 2023

99

Shibata, M.; Nakanishi, Y.; Abe, J.; Arima-Osonoi, H.; Iwase, H.;
Shibayama, M.; Motokawa, R.; Kumada, T.; Takata, S.; Yamamoto,K.; Takenaka, M.; Miyazaki, T., Structural Changes of Polystyrene Particles in Subcritical and Supercritical Water Revealed byin Situ Small-Angle Neutron Scattering, Polym. J., 55, 1165-1170(2023).
Shimokita, K.; Yamamoto, K.; Miyata, N.; Nakanishi, Y.; Shibata,M.; Takenaka, M.; Yamada, N. L.; Seto, H.; Aoki, H.; Miyazaki,T., Neutron Reflectivity Study on the Nanostructure of PMMA
Chains near Substrate Interfaces Based on Contrast Variation
Accompanied with Small Molecule Sorption, Soft Matter, 19, 20822089 (2023).
― Molecular Rheology ―Ohashi, N.; Kaneko, R.; Sakai, C.; Wasai, Y.; Higuchi, S.; Yazawa,
K.; Tahara, H.; Handa, T.; Nakamura, T.; Murdey, R.; Kanemitsu,
Y.; Wakamiya, A., Bilayer Indium Tin Oxide Electrodes for
Deformation‐Free Ultrathin Flexible Perovskite Solar Cells, Sol.
RRL, 7(13), 2300221 (2023).
Liu, W.; Hu, S.; Pascual, J.; Nakano, K.; Murdey, R.; Tajima, K.;
Wakamiya, A., Tin Halide Perovskite Solar Cells with OpenCircuit Voltages Approaching the Shockley–Queisser Limit, ACS
Appl. Mater. Interfaces, 15(27), 32487-32495 (2023).
Iwai, K.; Mizuhata, Y.; Nakamura, T.; Goto, M.; Wakamiya, A.;
Shimakawa, Y.; Tokitoh, N., Solid‐State Chromism of Zwitterionic
Triarylmethylium Salts, Eur. J. Inorg. Chem., 26(31), e202300337(2023).

Matsumiya, Y.; Sato, T.; Chen, Q.; Watanabe, H., Rouse Analysis
of Nonlinear Rheology of Unentangled Polymer Melts under Fast
Shear: Viscoelastic Response to Superposed Oscillatory Strain,
Macromolecules, 56(8), 2930-2938 (2023).

Higashimura, C.; Yumoto, G.; Yamada, T.; Nakamura, T.; Harata,F.; Hirori, H.; Wakamiya, A.; Kanemitsu, Y., Spontaneous
Polarization Induced Optical Responses in a Two-Dimensional
Ferroelectric Halide Perovskite, J. Phys. Chem. A, 14(37), 83608366 (2023).

Miyamoto, S.; Sato, T.; Taniguchi, T., Stretch-Orientation-Induced
Reduction of Friction in Well-Entangled Bidisperse Blends: A
Dual Slip-Link Simulation Study, Rheol. Acta, 62(1), 57-70 (2023).

ADVANCED RESEARCH CENTER FOR BEAM SCIENCE― Particle Beam Science ―Sato, T.; Gong, Y.; Larson, R. G., Testing the Ability of the SlipSpring Model to Describe Constraint Release Effects Using
Experimental Linear and Nonlinear Rheology, Macromolecules,
56(20), 8116-8132 (2023).
— Molecular Aggregates ―Tsuchiya, T.; Hamano, T.; Inoue, M.; Nakamura, T.; Wakamiya,A.; Mazaki, Y., Intense Absorption of Azulene Realized by
Molecular Orbital Inversion, Chem. Commun., 59(71), 1060410607 (2023).
Hashimoto, R.; Nakamura, T.; Truong, M. A.; Murdey, R.;
Wakamiya, A., Effects of Electron-Accepting Substituents on the
Fluorescence of Oxygen-Bridged Triarylamine, Dyes Pigm., 215,
111281 (2023).
Hu, S.; Zhao, P.; Nakano, K.; Oliver, R. D. J.; Pascual, J.; Smith, J.
A.; Yamada, T.; Truong, M. A.; Murdey, R.; Shioya, N.; Hasegawa,
T.; Ehara, M.; Johnston, M. B.; Tajima, K.; Kanemitsu, Y.; Snaith,
H. J.; Wakamiya, A., Synergistic Surface Modification of TinLead Perovskite Solar Cells, Adv. Mater., 35(9), 2208320 (2023).
Truong, M. A.; Funasaki, T.; Ueberricke, L.; Nojo, W.; Murdey,
R.; Yamada, T.; Hu, S.; Akatsuka, A.; Sekiguchi, N.; Hira, S.; Xie,
L.; Nakamura, T.; Shioya, N.; Kan, D.; Tsuji, Y.; Iikubo, S.; Yoshida,H.; Shimakawa, Y.; Hasegawa, T.; Kanemitsu, Y.; Suzuki, T.;
Wakamiya, A., Tripodal Triazatruxene Derivative as a Face-On
Oriented Hole-Collecting Monolayer for Efficient and Stable
Inverted Perovskite Solar Cells, J. Am. Chem. Soc., 145(13), 75287539 (2023).
Hu, S.; Smith, J. A.; Snaith, H. J.; Wakamiya, A., Prospects for
Tin-Containing Halide Perovskite Photovoltaics, Precis. Chem.,
1(2), 69-82 (2023).
Tan, T.; Nakamura, T.; Murdey, R.; Hu, S.; Truong, M. A.;
Wakamiya, A., BAr2‐Bridged Azafulvene Dimers with Tunable
Energy Levels for Photostable Near‐Infrared Dyes, Chem. Eur. J.,
29(34), e202300529 (2023).

100

PUBLICATIONS

Tsukada, K.; Abe, Y.; Enokizono, A.; Goke, T.; Hara, M.; Honda,
Y.; Hori, T.; Ichikawa, S.; Ito, Y.; Kurita, K.; Legris, C.; Maehara,Y.; Ohnishi, T.; Ogawara, R.; Suda, T.; Tamae, T.; Wakasugi,
M.; Watanabe, M.; Wauke, H., First Observation of Electron
Scattering from Online-Produced Radioactive Target, Phys. Rev.
Lett., 131(9), 92502 (2023).
Ogawara, R.; Abe, Y.; Ohnishi, T.; Enokizono, A.; Hara, M.; Hori,T.; Ichikawa, S.; Kurita, K.; Maehara, Y.; Suda, T.; Tsukada, K.;
Wakasugi, M.; Watanabe, M.; Wauke, H., Ion-Trapping Properties of SCRIT: Time Evolutions of 138Ba Charge State Distributions, Nuclear Instruments and Methods in Physics Research
Section B: Beam Interactions with Materials and Atoms, 541,
90-92 (2023).
Miyata, K.; Ogawara, R.; Ishikawa, M., Improvement of Crystal
Identification Accuracy for Depth-of-Interaction Detector Systemwith Peak-to-Charge Discrimination Method, Sensors, 23(10),4584 (2023).
― Laser Matter Interaction Science ―Li, E.; Uehara, H.; Tokita, S.; Yao, W.; Yasuhara, R., A Hybrid
Quantum Cascade Laser/Fe:ZnSe Amplifier System for Power
Scaling of CW Lasers at 4.0–4.6 Μm, Opt. Laser Technol., 157,
108783 (2023).
Ozaki, T.; Abe, Y.; Arikawa, Y.; Sentoku, Y.; Kawanaka, J.;
Tokita, S.; Miyanaga, N.; Jitsuno, T.; Nakata, Y.; Tsubakimoto,K.; Sunahara, A.; Johzaki, T.; Miura, E.; Komeda, O.; Iwamoto,A.; Sakagami, H.; Okihara, S.; Ishii, K.; Hanayama, R.; Mori, Y.;
Kitagawa, Y., Hot Electron and Ion Spectra on Blow-off Plasma
Free Target in GXII-LFEX Direct Fast Ignition Experiment, Nucl.
Fusion, 63, 36009 (2023).
Arikawa, Y.; Morace, A.; Abe, Y.; Iwata, N.; Sentoku, Y.; Yogo,
A.; Matsuo, K.; Nakai, M.; Nagatomo, H.; Mima, K.; Nishimura,H.; Fujioka, S.; Kodama, R.; Inoue, S.; Hashida, M.; Sakabe, S.;
De Luis, D.; Gatti, G.; Huault, M.; Pérez-Hernández, J. A.; Roso,
L.; Volpe, L., Demonstration of Efficient Relativistic Electron
Acceleration by Surface Plasmonics with Sequential Target
Processing Using High Repetition Lasers, Phys. Rev. Res., 5(1),13062 (2023).

Ishibashi, F.; Hasada, T.; Homma, K.; Kirita, Y.; Kanai, T.;
Masuno, S.; Tokita, S.; Hashida, M., Pilot Search for Axion-Like
Particles by a Three-Beam Stimulated Resonant Photon Collider
with Short Pulse Lasers, Universe, 9(3), 123 (2023).

Sugimoto, Y.; Hara, K.; Haruta, M.; Kurata, H.; Kim, J.-H.;
Hwang, T.; Nakamichi, M.; Miyamoto, M., Effect of the Internal
Pressure of Helium Bubbles on the Morphology and Mobility of
Beryllium, Fusion Eng. Des., 191, 113720 (2023).

Fujiwara, M.; Inoue, S.; Masuno, S.-I.; Fu, H.; Tokita, S.; Hashida,M.; Mizuochi, N., Creation of NV Centers over a MillimeterSized Region by Intense Single-Shot Ultrashort Laser Irradiation,
APL Photonics, 8(3), 36108 (2023).

Miyamoto, M.; Sano, K.; Sawae, T.; Haruta, M.; Kurata, H.,
Effect of Helium Irradiation on the Hydrogen Isotope Retention
in Tungsten by in situ TEM and STEM-EELS Analysis, Nucl.
Mater. Energy, 36, 101484-1-101484-6 (2023).

Arai, K.; Okazaki, D.; Morichika, I.; Ashihara, S., All-Solid-State
Optical-Field-Sensitive Detector for Sub-Nanojoule Pulses Using
Metal–Insulator Hybrid Nanostructure, ACS Photonics, 10(6),1702-1707 (2023).

Ruangchai, K.; Tongsri, R.; Pearce, J. T. H.; Chairuangsri, T.;
Nusen, S.; Kurata, H.; Haruta, M.; Kiyomura, T.; Yamaguchi, A.;
Wiengmoon, A., Electron Microscopy of Carbides in Annealed
28 wt% Cr - 1 wt% (Mo/W) Cast Irons, Mater. Charact., 198,
112723 (2023).

Goya, K.; Sasanuma, H.; Ishida, G.; Uehara, H.; Tokita, S.,
Fusion Splicing of Plastic Optical Fibers Using a Mid-IR Fiber
Laser, Appl. Phys. Express, 16(5), 52006 (2023).
Homma, K.; Tesileanu, O.; Nakamiya, Y.; Kirita, Y.; Chiochiu,C.; Cuciuc, M.; Giubega, G.; Hasada, T.; Hashida, M.; Ishibashi,F.; Kanai, T.; Kodama, A.; Masuno, S.; Miyamaru, T.; Neagu,
L.; Rodrigues, V. R. M.; Rosu, M. M.; Sakabe, S.; Tamlyn, J.;
Tazlauanu, S. V.; Tokita, S., Challenge of Search for Cosmological
Dark Components with High-Intensity Lasers and Beyond, Eur.
Phys. J. A, 59, 109 (2023).
Masuno, S.; Hashida, M.; Zen, H., Formation of Periodic Surface
Structures on Semiconductors under Mid-Infrared Free-Electron
Laser Irradiation, EEJ Trans. Fundam. Mater., 143(10), 320-324(2023).
[Others]
Okazaki, D.; Song, W.; Morichika, I.; Ashihara, S., Mode-Locked
Cr:ZnS Laser with Multiple Spectral Peaks at Molecular Vibrational Resonances, Proceedings of the 2022 Conference on Lasers
and Electro-Optics Pacific Rim, CTuA1A-04 (2023).
Tokita, S., Progress in Mid-Infrared Fiber Lasers, Review of Laser
Engineering, 51(1), 22-26 (2023).
― Electron Microscopy and Crystal Chemistry ―Iwashimizu, C.; Haruta, M.; Nemoto, T.; Kurata, H., Different
Atomic Contrasts in HAADF Images and EELS Maps of Rutile
TiO2, Microscopy, 72(4), 353-360 (2023).
Lin, I.-C.; Haruta, M.; Nemoto, T.; Goto, M.; Shimakawa, Y.;
Kurata, H., Extraction of Anisotropic Thermal Vibration Factors
for Oxygen from the Ti L2,3-Edge in SrTiO3, J. Phys. Chem. C,
127(36), 17802-17808 (2023).
Shen, Y.; Haruta, M.; Lin, I.-C.; Xie, L.; Kan, D.; Shimakawa, Y.,
Stabilization of Ferroelectric Hf0.5Zr0.5O2 Epitaxial Films via
Monolayer Reconstruction Driven by Valence-Dependent Interfacial Redox Reaction and Intralayer Electron Transfer, Phys.
Rev. Mater., 7, 114405 (2023).
Watanabe, H.; Ekuni, K.; Okuda, Y.; Nakayama, R.; Kawano, K.;
Iwanaga, T.; Yamaguchi, A.; Kiyomura, T.; Miyake, H.; Yamagami,
M.; Tajima, T.; Kitai, T.; Hayashi, T.; Nishiyama, N.; Kusano, Y.;
Kurata, H.; Takaguchi, Y.; Orita, A., Composite Formation of
Anthrylene- and Ferrocenoyl-Substituted Phenyleneethynylenes
with Single-Wall Carbon Nanotubes (SWCNTs), Bull. Chem. Soc.
Jpn., 96(1), 57-64 (2023).

Makming, P.; Homnan, S.; Ngamjarurojana, A.; Rimjaem, S.;
Gardchareon, A.; Sawada, T.; Haruta, M.; Pakawatpanurut, P.;
Wongratanaphisan, D.; Kanjanaboos, P.; Intaniwet, A.; Ruankham,
P., Efficient and Stable Carbon-Based Perovskite Solar Cells
Enabled by Mixed CuPc:CuSCN Hole Transporting Layer for
Indoor Applications, ACS Appl. Mater. Interfaces, 15(12), 1548615497 (2023).
Pimta, K.; Autthawong, T.; Yodying, W.; Phromma, C.; Haruta,
M.; Kurata, H.; Sarakonsri, T.; Chimupala, Y., Development ofBronze Phase Titanium Dioxide Nanorods for Use as Fast-Charging
Anode Materials in Lithium-Ion Batteries, ACS Omega, 8(17),15360-15370 (2023).
Yodying, W.; Autthawong, T.; Namsar, O.; Kiyomura, T.; Haruta,
M.; Kurata, H.; Chairuangsri, T.; Sarakonsri, T., Recycling Water
Hyacinth Stem Waste for Cost-Effective Production of Carbon/
FeOx Nanocomposite Anodes for Sustainable Fast-Charging
Lithium-Ion Batteries, J. Mater. Sci. Mater. Electron., 34(16),1319-1-1319-13 (2023).
Yodying, W.; Sarakonsri, T.; Ratsameetammajak, N.; Khunpakdee,
K.; Haruta, M.; Autthawong, T., Low-Cost Production of Fe3O4/C
Nanocomposite Anodes Derived from Banana Stem Waste
Recycling for Sustainable Lithium-Ion Batteries, Crystals, 13(2),280-1-280-17 (2023).
Dobrică, E.; Ishii, H. A.; Bradley, J. P.; Ohtaki, K.; Brearley, A. J.;
Noguchi, T.; Matsumoto, T.; Miyake, A.; Igami, Y.; Haruta, M.;
Saito, H.; Hata, S.; Seto, Y.; Miyahara, M.; Tomioka, N.; Leroux,
H.; Le Guillou, C.; Jacob, D.; de la Peña, F.; Laforet, S.; Marinova,
M.; Langenhorst, F.; Harries, D.; Beck, P.; Phan, T. H. V.; Rebois,
R.; Abreu, N. M.; Gray, J.; Zega, T.; Zanetta, P.-M.; Thompson,
M. S.; Stroud, R.; Burgess, K.; Cymes, B. A.; Bridges, J. C.;
Hicks, L.; Lee, M. R.; Daly, L.; Bland, P. A.; Zolensky, M. E.;
Frank, D. R.; Martinez, J.; Tsuchiyama, A.; Yasutake, M.;
Matsuno, J.; Okumura, S.; Mitsukawa, I.; Uesugi, K.; Uesugi, M.;
Takeuchi, A.; Sun, M.; Enju, S.; Takigawa, A.; Michikami, T.;
Nakamura, T.; Matsumoto, M.; Nakauchi, Y.; Yurimoto, H.; Okazaki,R.; Yabuta, H.; Naraoka, H.; Sakamoto, K.; Tachibana, S.; Yada,T.; Nishimura, M.; Nakato, A.; Miyazaki, A.; Yogata, K.; Abe,M.; Okada, T.; Usui, T.; Yoshikawa, M.; Saiki, T.; Tanaka, S.;
Terui, F.; Nakazawa, S.; Watanabe, S.; Tsuda, Y., Nonequilibrium
Spherulitic Magnetite in the Ryugu Samples, Geochim. Cosmochim.
Acta, 346, 65-75 (2023).

ICR ANNUAL REPORT, 2023

101

Noguchi, T.; Matsumoto, T.; Miyake, A.; Igami, Y.; Haruta, M.;
Saito, H.; Hata, S.; Seto, Y.; Miyahara, M.; Tomioka, N.; Ishii, H.
A.; Bradley, J. P.; Ohtaki, K. K.; Dobrică, E.; Leroux, H.; Le
Guillou, C.; Jacob, D.; de la Peña, F.; Laforet, S.; Marinova, M.;
Langenhorst, F.; Harries, D.; Beck, P.; Phan, T. H. V.; Rebois, R.;
Abreu, N. M.; Gray, J.; Zega, T.; Zanetta, P.-M.; Thompson, M.
S.; Stroud, R.; Burgess, K.; Cymes, B. A.; Bridges, J. C.; Hicks,
L.; Lee, M. R.; Daly, L.; Bland, P. A.; Zolensky, M. E.; Frank, D.
R.; Martinez, J.; Tsuchiyama, A.; Yasutake, M.; Matsuno, J.;
Okumura, S.; Mitsukawa, I.; Uesugi, K.; Uesugi, M.; Takeuchi,
A.; Sun, M.; Enju, S.; Takigawa, A.; Michikami, T.; Nakamura,T.; Matsumoto, M.; Nakauchi, Y.; Abe, M.; Arakawa, M.; Fujii,A.; Hayakawa, M.; Hirata, N.; Hirata, N.; Honda, R.; Honda, C.;
Hosoda, S.; Iijima, Y.; Ikeda, H.; Ishiguro, M.; Ishihara, Y.; Iwata,T.; Kawahara, K.; Kikuchi, S.; Kitazato, K.; Matsumoto, K.;
Matsuoka, M.; Mimasu, Y.; Miura, A.; Morota, T.; Nakazawa, S.;
Namiki, N.; Noda, H.; Noguchi, R.; Ogawa, N.; Ogawa, K.;
Okada, T.; Okamoto, C.; Ono, G.; Ozaki, M.; Saiki, T.; Sakatani,N.; Sawada, H.; Senshu, H.; Shimaki, Y.; Shirai, K.; Sugita, S.;
Takei, Y.; Takeuchi, H.; Tanaka, S.; Tatsumi, E.; Terui, F.;
Tsukizaki, R.; Wada, K.; Yamada, M.; Yamada, T.; Yamamoto, Y.;
Yano, H.; Yokota, Y.; Yoshihara, K.; Yoshikawa, M.; Yoshikawa,
K.; Fukai, R.; Furuya, S.; Hatakeda, K.; Hayashi, T.; Hitomi, Y.;
Kumagai, K.; Miyazaki, A.; Nakato, A.; Nishimura, M.; Soejima,
H.; Suzuki, A. I.; Usui, T.; Yada, T.; Yamamoto, D.; Yogata, K.;
Yoshitake, M.; Connolly, H. C., Jr; Lauretta, D. S.; Yurimoto, H.;
Nagashima, K.; Kawasaki, N.; Sakamoto, N.; Okazaki, R.;
Yabuta, H.; Naraoka, H.; Sakamoto, K.; Tachibana, S.; Watanabe,S.; Tsuda, Y., A Dehydrated Space-Weathered Skin Cloaking theHydrated Interior of Ryugu, Nat. Astron, 7, 170-181 (2023).

― Advanced Solid State Chemistry ―INTERNATIONAL RESEARCH CENTER FOR ELEMENTSSCIENCE― Synthetic Organotransformation ―Narita, H.; Ishizuka, J.; Kan, D.; Shimakawa, Y.; Yanase, Y.; Ono,T., Magnetization Control of Zero‐Field Intrinsic Superconducting
Diode Effect, Adv. Mater., 35(40), 2304083 (2023).

Negi, S.; Imanishi, M.; Hamori, M.; Kawahara-Nakagawa, Y.;
Nomura, W.; Kishi, K.; Shibata, N.; Sugiura, Y., The Past, Present,
and Future of Artificial Zinc Finger Proteins: Design Strategies
and Chemical and Biological Applications, J. Biol. Inorg. Chem.,
28(3), 249-261 (2023).

Iwai, K.; Mizuhata, Y.; Nakamura, T.; Goto, M.; Wakamiya, A.;
Shimakawa, Y.; Tokitoh, N., Solid‐State Chromism of Zwitterionic
Triarylmethylium Salts, Eur. J. Inorg. Chem., 26(31), e202300337(2023).

Mineo, K., Aspects of Forestry Economics in Japan before WorldWar II, Applied Forest Science, 32(1), 21-29 (2023).
Doba, T., Iron-Catalyzed C-H/C-H Coupling for Synthesis of
Functional Small Molecules and Polymers; Springer Nature
Singapore, 2023, Springer Theses, 1-153 (2023).
Nakajima, S.; Hashimoto, T.; Lu, S.; Hashizume, D.; Matsuda,
H.; Hatakeyama, T.; Isozaki, K.; Takaya, H.; Nakamura, M.,
SciPROP-R: An Effective Bisphosphine Ligand for the ChemoSelective Iron-Catalyzed Suzuki-Miyaura Coupling of Alkyl
Chlorides, Bull. Chem. Soc. Jpn., 96(11), 1298-1309 (2023).
Shang, R.; Nakamura, E.; Doba, T.; Fukuma, S., Versatile Synthesis
of Trisphosphines Bearing Phenylene and Vinylene Backbones
Useful for Metal Catalysis and Materials Applications, Synthesis,55(11), 1690-1699 (2023).
[Others]
Mineo, K., Prospects for the Forest Chemical Industry (Open
Online Seminar), FOREST ECONOMY, 76(4), 22-28 (2023).

Ham, W. S.; Ho, T. H.; Shiota, Y.; Iino, T.; Ando, F.; Ikebuchi, T.;
Kotani, Y.; Nakamura, T.; Kan, D.; Shimakawa, Y.; Moriyma, T.; Im,
E.; Lee, N. J.; Kim, K. W.; Hong, S. C.; Rhim, S. H.; Ono, T.; Kim,
S., Bulk Rashba‐Type Spin Splitting in Non‐Centrosymmetric
Artificial Superlattices, Adv. Sci., 10(12), 2206800 (2023).
Isoda, Y.; Kan, D.; Majima, T.; Shimakawa, Y., OrientationDependent Electrochemical Reduction and Proton Evolution in
the Oxygen-Deficient Perovskite SrFeO2.5+y, Appl. Phys. Express,
16(1), 15506 (2023).
Kamada, T.; Ueda, T.; Fukuura, S.; Yumura, T.; Hosokawa, S.;
Tanaka, T.; Kan, D.; Shimakawa, Y., Ultralong Distance Hydrogen
Spillover Enabled by Valence Changes in a Metal Oxide Surface,
J. Am. Chem. Soc., 145(3), 1631 (2023).
Takahashi, R.; Ohkochi, T.; Kan, D.; Shimakawa, Y.; Wadati, H.,
Optically Induced Magnetization Switching in NiCo2O4 Thin
Films Using Ultrafast Lasers, ACS Appl. Electron. Mater., 5(2),748-753 (2023).
Truong, M. A.; Funasaki, T.; Ueberricke, L.; Nojo, W.; Murdey,
R.; Yamada, T.; Hu, S.; Akatsuka, A.; Sekiguchi, N.; Hira, S.; Xie,
L.; Nakamura, T.; Shioya, N.; Kan, D.; Tsuji, Y.; Iikubo, S.;
Yoshida, H.; Shimakawa, Y.; Hasegawa, T.; Kanemitsu, Y.;
Kanemitsu, Y.; Suzuki, T.; Wakamiya, A., Tripodal Triazatruxene
Derivative as a Face-On Oriented Hole-Collecting Monolayer
for Efficient and Stable Inverted Perovskite Solar Cells, J. Am.
Chem. Soc., 145(13), 7528-7539 (2023).

Lin, I-C.; Haruta, M.; Nemoto, T.; Goto, M.; Shimakawa, Y.;
Kurata, H., Extraction of Anisotropic Thermal Vibration Factors
for Oxygen from the Ti L2,3-Edge in SrTiO3, J. Phys. Chem. C,
127(36), 17802-17808 (2023).
Chen, C.; Kosugi, Y.; Goto, M.; Shimakawa, Y., Thermal Properties and Phase Transition Behaviors of Possible Caloric Materials
Bi0.95Ln0.05NiO3, J. Mater. Chem. A, 11, 15389-15393 (2023).
Shimakawa, Y.; Kosugi, Y., Giant Caloric Effects in Charge-SpinLattice Coupled Transition-Metal Oxides, J. Mater. Chem. A, 11,12695-12702 (2023).
Zhang, Y.; Sawamura, M.; Harada, M.; Noda, Y.; Nakayama, M.;
Goto, M.; Kan, D.; Shimakawa, Y.; Campéon, B. D. L.; Shibata,D.; Ohta, T.; Yabuuchi, N., Partially Reversible Anionic Redox
for Lithium-Excess Cobalt Oxides with Cation-Disordered
Rocksalt Structure, J. Phys. Chem. C, 127(5), 2194-2203 (2023).
Iihoshi, M.; Goto, M.; Kosugi, Y.; Shimakawa, Y., Cascade
Charge Transitions of Unusually High and Mixed Valence Fe3.5+
in the A-Site Layer-Ordered Double Perovskite SmBaFe2O6, J.
Am. Chem. Soc., 145(19), 10756-10762 (2023).
Kurian, M. M.; Tan, Z.; Shimakawa, Y.; Santhosh, P. N., Probing
Griffiths Phase like Behavior and Exchange Bias Phenomena in
6H Ba3Co0.5Mn0.5Ru2O9 by B-Site Doping, J. Appl. Phys., 134,
43901 (2023).

102

PUBLICATIONS

― Organometallic Chemistry ―Masaoka, K.; Taue, H.; Higaki, T.; Ohki, Y.; Ogasawara, M.,
Competitive Double Friedel–Crafts 2,5- and 1′,2-Diacylation of
Monophosphaferrocenes, Organometallics, 42(13), 1667-1673(2023).
Tanifuji, K.; Ohta, S.; Ohki, Y.; Seino, H., Activation of Unsaturated Small Molecules by Bio-Relevant Multinuclear MetalSulfur Clusters, Coord. Chem. Rev., 475, 214838 (2023).
Wakabayashi, S.; Takumi, M.; Kamio, S.; Wakioka, M.; Ohki, Y.;
Nagaki, A., Flow‐Chemistry‐Enabled Synthesis of 5‐Diethylboryl‐
2,3′‐bipyridine and Its Self‐Assembly Dynamics, Chem. Eur. J.,
29(9), e202202882 (2023).
Masaoka, K.; Taue, H.; Wakioka, M.; Ohki, Y.; Ogasawara, M.,
Asymmetric Metathesis Dimerization/Kinetic Resolution of
Racemic Planar-Chiral Vinylphosphaferrocenes, Organometallics,
42(13), 1629-1638 (2023).
Izu, H.; Tabe, H.; Namiki, Y.; Yamada, H.; Horike, S., Heterogenous CO2 Reduction Photocatalysis of Transparent Coordination
Polymer Glass Membranes Containing Metalloporphyrins, Inorg.
Chem., 62(29), 11342-11349 (2023).
Izu, H.; Bhave, D. G.; Matsuoka, Y.; Sameera, W. M. C.; Tanifuji,K.; Ohki, Y., Synthesis, Characterization, and Catalytic Activityof a Cubic [Mo3S4Pd] Cluster Bearing Bulky Cyclopentadienyl
Ligands, Eur. J. Inorg. Chem., 26(29), e202300399 (2023).
[Others]
Tanifuji, K.; Ohki, Y., Studies on Biosynthesis and Catalysis ofMetal-Sulfur Clusters, Bulletin of Japan Society of Coordination
Chemistry, 81, 58-65 (2023).
Tanifuji, K.; Ohki, Y., Reduction of Nitrogen by Synthetic
Metal Complexes Mimicking the Active Site of Nitrogenase,
BIOSCIENCE & INDUSTRY, 81(1), 40-42 (2023).
― Nanophotonics ―Sekiguchi, F.; Sakamoto, M.; Nakagawa, K.; Tahara, H.; Sato,S. A.; Hirori, H.; Kanemitsu, Y., Enhancing High Harmonic
Generation in GaAs by Elliptically Polarized Light Excitation,
Phys. Rev. B, 108, 205201 (2023).
Nakagawa, K.; Ishii, N.; Kanemitsu, Y.; Hirori, H., Mid-Infrared
Pulse Generation Using Multi-Plate White-Light Generation and
Optical Parametric Amplification in LiGaS2 Crystals, Appl. Phys.
Express, 16(3), 32001 (2023).
Yamada, Y.; Kajino, Y.; Kanemitsu, Y., Evaluation of ElectronPhonon Interactions in Halide Perovskites toward Semiconductor
Optical Refrigeration, Photonic Heat Engines: Science andApplications V, 12437, 1243704 (2023).
Truong, M. A.; Funasaki, T.; Ueberricke, L.; Nojo, W.; Murdey,
R.; Yamada, T.; Hu, S.; Akatsuka, A.; Sekiguchi, N.; Hira, S.; Xie,
L.; Nakamura, T.; Shioya, N.; Kan, D.; Tsuji, Y.; Iikubo, S.;
Yoshida, H.; Shimakawa, Y.; Hasegawa, T.; Kanemitsu, Y.; Suzuki,
T.; Wakamiya, A., Tripodal Triazatruxene Derivative as a Face-On
Oriented Hole-Collecting Monolayer for Efficient and Stable
Inverted Perovskite Solar Cells, J. Am. Chem. Soc., 145(13), 75287539 (2023).

Zhang, Z.; Sekiguchi, F.; Moriyama, T.; Furuya, S. C.; Sato, M.;
Satoh, T.; Mukai, Y.; Tanaka, K.; Yamamoto, T.; Kageyama, H.;
Kanemitsu, Y.; Hirori, H., Generation of Third-Harmonic Spin
Oscillation from Strong Spin Precession Induced by Terahertz
Magnetic near Fields, Nat. Commun., 14(1), 1795 (2023).
Handa, T.; Yamada, T.; Kanemitsu, Y., Review―Photoluminescence Characterization of Halide Perovskite Materials and Solar
Cells, ECS J. Solid State Sci. Technol., 12(5), 56004 (2023).
Ohashi, N.; Kaneko, R.; Sakai, C.; Wasai, Y.; Higuchi, S.; Yazawa,
K.; Tahara, H.; Handa, T.; Nakamura, T.; Murdey, R.; Kanemitsu,
Y.; Wakamiya, A., Bilayer Indium Tin Oxide Electrodes for
Deformation‐Free Ultrathin Flexible Perovskite Solar Cells, Sol.
RRL, 7(13), 2300221 (2023).
Cho, K.; Yamada, T.; Saruyama, M.; Sato, R.; Teranishi, T.;
Kanemitsu, Y., Temperature Dependence of Photoluminescence
Spectrum of Single Lead Halide Perovskite Nanocrystals: Effectof Size on the Phase Transition Temperature, J. Chem. Phys.,
158(20), 201104 (2023).
Kobiyama, E.; Tahara, H.; Saruyama, M.; Sato, R.; Teranishi, T.;
Kanemitsu, Y., Picosecond Trion Photocurrent Dynamics in FAPbI3
Quantum Dot Films, Appl. Phys. Lett., 122(25), 252106 (2023).
Higashimura, C.; Yumoto, G.; Yamada, T.; Nakamura, T.; Harata,F.; Hirori, H.; Wakamiya, A.; Kanemitsu, Y., Spontaneous
Polarization Induced Optical Responses in a Two-Dimensional
Ferroelectric Halide Perovskite, J. Phys. Chem. Lett., 14(37),8360-8366 (2023).
Hu, S.; Zhao, P.; Nakano, K.; Oliver, R. D. J.; Pascual, J.; Smith,J. A.; Yamada, T.; Truong, M. A.; Murdey, R.; Shioya, N.; Hasegawa,
T.; Ehara, M.; Johnston, M. B.; Tajima, K.; Kanemitsu, Y.; Snaith,
H. J.; Wakamiya, A., Synergistic Surface Modification of TinLead Perovskite Solar Cells, Adv. Mater., 35(9), 2208320 (2023).
[Others]
Kanemitsu, Y.; Hirori, H., Nonlinear Laser Spectroscopy of Halide
Perovskite Semiconductors, OYO BUTURI, 92(1), 30-34 (2023).
BIOINFORMATICS CENTER― Chemical Life Science ―Zhang, R.; Takemura, M.; Murata, K.; Ogata, H., Create a New
Family (“Mamonoviridae”), a Genus (“Medusavirus”), and Two
Species (“Medusavirus Medusae” and “Medusavirus Sthenus”)
in the Phylum Nucleocytoviricota., ICTV Taxonomic Proposal,
168(3) (2023).
Muro, T.; Hikida, H.; Fujii, T.; Kiuchi, T.; Katsuma, S., Two
Complete Genomes of Male-Killing Wolbachia Infecting Ostrinia
Moth Species Illuminate Their Evolutionary Dynamics andAssociation with Hosts, Microb. Ecol., 86(3), 1740-1754 (2023).
Gaïa, M.; Meng, L.; Pelletier, E.; Forterre, P.; Vanni, C.; FernandezGuerra, A.; Jaillon, O.; Wincker, P.; Ogata, H.; Krupovic, M.;
Delmont, T. O., Mirusviruses Link Herpesviruses to Giant Viruses,
Nature, 616(7958), 783-789 (2023).
Okazaki, Y.; Nguyen, T. T.; Nishihara, A.; Endo, H.; Ogata, H.;
Nakano, S.; Tamaki, H., A Fast and Easy Method to Co-Extract
DNA and RNA from an Environmental Microbial Sample,
Microbes Environ., 38(1), ME22102 (2023).

ICR ANNUAL REPORT, 2023

103

Fujita, H.; Ushio, M.; Suzuki, K.; Abe, M.S.; Yamamichi, M.;
Okazaki, Y.; Canarini, A.; Hayashi, I.; Fukushima, K.; Fukuda,
S.; Kiers, E.T.; Toju, H., Metagenomic Analysis of Ecological
Niche Overlap and Community Collapse in Microbiome Dynamics,
Front. Microbiol., 14 (2023).
Tominaga, K.; Ogawa-Haruki, N.; Nishimura, Y.; Watai, H.;
Yamamoto, K.; Ogata, H.; Yoshida, T., Prevalence of Viral
Frequency-Dependent Infection in Coastal Marine Prokaryotes
Revealed Using Monthly Time Series Virome Analysis, mSystems,
8(1), e0093122 (2023).

Kaneko, H.; Endo, H.; Henry, N.; Berney, C.; Mahe, F.; Poulain,J.; Labadie, K.; Beluche, O.; El Hourany, R.; Acinas, S. G.; Babin,M.; Bork, P.; Bowler, C.; Cochrane, G.; de Vargas, C.; Gorsky, G.;
Guidi, L.; Grimsley, N.; Hingamp, P.; Iudicone, D.; Jaillon, O.;
Kandels, S.; Karsenti, E.; Not, F.; Poulton, N.; Pesant, S.; Sardet,C.; Speich, S.; Stemmann, L.; Sullivan, M. B.; Sunagawa, S.;
Chaffron, S.; Wincker, P.; Nakamura, R.; Karp-Boss, L.; Boss, E.;
Bowler, C.; de Vargas, C.; Tomii, K.; Ogata, H., Predicting Global
Distributions of Eukaryotic Plankton Communities from Satellite
Data, ISME commun., 3(1), 101 (2023).

Zhang, R.; Takemura, M.; Murata, K.; Ogata, H., “Mamonoviridae”,
a Proposed New Family of the Phylum Nucleocytoviricota, Arch.
Virol., 168(3), 80 (2023).

Meng, L.; Delmont, T. O.; Gaia, M.; Pelletier, E.; FernandezGuerra, A.; Chaffron, S.; Neches, R. Y.; Wu, J.; Kaneko, H.;
Endo, H.; Ogata, H., Genomic Adaptation of Giant Viruses in
Polar Oceans, Nat. Commun., 14, 6233 (2023).

Tanabe, Y.; Yamaguchi, H.; Yoshida, M.; Kai, A.; Okazaki, Y.,
Characterization of a Bloom-Associated Alphaproteobacterial
Lineage, ‘Candidatus Phycosocius’: Insights into Freshwater
Algal-Bacterial Interactions, ISME commun., 3(1), 20 (2023).

Zhao, H.; Zhang, R.; Wu, J.; Meng, L.; Okazaki, Y.; Hikida, H.;
Ogata, H., A 1.5-Mb Continuous Endogenous Viral Region in the
Arbuscular Mycorrhizal Fungus Rhizophagus Irregularis, Virus
Evol., 9(2), vead064 (2023).

Fujita, H.; Ushio, M.; Suzuki, K.; Abe, M. S.; Yamamichi, M.;
Okazaki, Y.; Canarini, A.; Hayashi, I.; Fukushima, K.; Fukuda,
S.; Kiers, E. T.; Toju, H., Facilitative Interaction Networks inExperimental Microbial Community Dynamics, Front. Microbiol.,
14 (2023).
Ban, H.; Sato, S.; Yoshikawa, S.; Yamada, K.; Nakamura, Y.;
Ichinomiya, M.; Sato, N.; Blanc-Mathieu, R.; Endo, H.; Kuwata,A.; Ogata, H., Genome Analysis of Parmales, the Sister Group of
Diatoms, Reveals the Evolutionary Specialization of Diatoms
from Phago-Mixotrophs to Photoautotrophs, Commun. Biol.,6(1), 697 (2023).
Hikida, H.; Okazaki, Y.; Zhang, R.; Nguyen, T. T.; Ogata, H., A
Rapid Genome‐Wide Analysis of Isolated Giant Viruses Using
MinION Sequencing, Environ. Microbiol., 25(11), 2621-2635(2023).
Rigonato, J.; Budinich, M.; Murillo, A. A.; Brandao, M. C.;
Karlusich, J. J. P.; Soviadan, Y. D.; Gregory, A. C.; Endo, H.;
Kokoszka, F.; Vik, D.; Henry, N.; Fremont, P.; Labadie, K.;
Zayed, A. A.; Dimier, C.; Picheral, M.; Searson, S.; Poulain, J.;
Kandels, S.; Pesant, S.; Karsenti, E.; Acinas, S. G.; Boss, E.;
Cochrane, G.; Gorsky, G.; Grimsley, N.; Guidi, L.; Hingamp, P.;
Karp-Boss, L.; Not, F.; Raes, J.; Sardet, C.; Speich, S.; Bork, P.;
Bowler, C.; de Vargas, C.; Eveillard, D.; Gehlen, M.; Iudicone,D.; Lombard, F.; Ogata, H.; Stemmann, L.; Sullivan, M. B.;
Sunagawa, S.; Wincker, P.; Chaffron, S.; Jaillon, O., Ocean-WideComparisons of Mesopelagic Planktonic Community Structures,
ISME commun., 3(1), 83 (2023).
Pascoal, F.; Tomasino, M. P.; Piredda, R.; Quero, G. M.; Torgo,
L.; Poulain, J.; Galand, P. E.; Fuhrman, J.; Mitchell, A.; Tinta, T.;
Dermastia, T. T.; Fernandez-Guerra, A.; Vezzi, A.; Logares, R.;
Malfatti, F.; Endo, H.; Dąbrowska, A. M.; De Pascale, F.; Sánchez,
P.; Henry, N.; Fosso, B.; Wilson, B.; Toshchakov, S.; Ferrant, G.
K.; Grigorov, I.; Vieira, F. R. J.; Costa, R.; Pesant, S.; Magalhaes,
C., Inter-Comparison of Marine Microbiome Sampling Protocols,
ISME commun., 3(1), 84 (2023).

― Mathematical Bioinformatics ―Tamura, T., Trimming Gene Deletion Strategies for GrowthCoupled Production in Constraint-Based Metabolic Networks:
TrimGdel, IEEE/ACM Trans. Comput. Biol. Bioinf., 20(2), 15401549 (2023).
Pan, T.; Li, C.; Bi, Y.; Wang, Z.; Gasser, R. B.; Purcell, A. W.;
Akutsu, T.; Webb, G. I.; Imoto, S.; Song, J., PFresGO: An Attention Mechanism-Based Deep-Learning Approach for Protein
Annotation by Integrating Gene Ontology Inter-Relationships,
Bioinformatics, 39(3), btad094 (2023).
Jia, X.; Zhao, P.; Li, F.; Qin, Z.; Ren, H.; Li, J.; Miao, C.; Zhao, Q.;
Akutsu, T.; Dou, G.; Chen, Z.; Song, J., ResNetKhib: A Novel Cell
Type-Specific Tool for Predicting Lysine 2-Hydroxyisobutylation
Sites via Transfer Learning, Briefings Bioinf., 24(2), bbad063 (2023).
Melkman, A. A.; Guo, S.; Ching, W.-K.; Liu, P.; Akutsu, T., On theCompressive Power of Boolean Threshold Autoencoders, IEEE
Trans. Neural Networks Learn. Syst., 34(2), 921-931 (2023).
Tamura, T., MetNetComp: Database for Minimal and Maximal
Gene-Deletion Strategies for Growth-Coupled Production of
Genome-Scale Metabolic Networks, IEEE/ACM Trans. Comput.
Biol. Bioinform., 20(6), 3748-3758 (2023).
Tamura, T.; Muto-fujita, A.; Tohsato, Y.; Kosaka, T., Gene Deletion
Algorithms for Minimum Reaction Network Design by MixedInteger Linear Programming for Metabolite Production inConstraint-Based Models: gDel_minRN, J. Comput. Biol., 30(5),553-568 (2023).
Wang, F.; Akutsu, T.; Mori, T., Metrics for RNA Secondary Structure Comparison, Methods Mol. Biol., 2586, 79-88 (2023).
Mori, T.; Takase, T.; Lan, K.-C.; Yamane, J.; Alev, C.; Kimura, A.;
Osafune, K.; Yamashita, J. K.; Akutsu, T.; Kitano, H.; Fujibuchi,W., eSPRESSO: Topological Clustering of Single-Cell Transcriptomics Data to Reveal Informative Genes for Spatio-Temporal
Architectures of Cells, BMC Bioinf., 24(252) (2023).
Xu, J.; Li, F.; Li, C.; Guo, X.; Landersdorfer, C.; Shen, H.-H.;
Peleg, A. Y.; Li, J.; Imoto, S.; Yao, J.; Akutsu, T.; Song, J.,
iAMPCN: A Deep-Learning Approach for Identifying Antimicrobial Peptides and Their Functional Activities, Briefings Bioinf.,
24(4), bbad240 (2023).

104

PUBLICATIONSShiota, K.; Suma, A.; Ogawa, H.; Yamaguchi, T.; Iida, A.; Hata,
T.; Matsushita, M.; Akutsu, T.; Tateno, M., AQDnet: Deep Neural
Network for Protein-Ligand Docking Simulation, ACS Omega,
8(26), 23925-23935 (2023).

Kobiyama, E; Tahara, H.; Saruyama, M.; Sato, R.; Teranishi, T.;
Kanemitsu, Y., Picosecond Trion Photocurrent Dynamics in
FAPbI3 Quantum Dot Films, Appl. Phys. Lett., 122, 252106(2023).

Chen, J.; Han, G.; Xu, A.; Akutsu, T.; Cai, H., Identifying miRNAGene Common and Specific Regulatory Modules for Cancer
Subtyping by a High-Order Graph Matching Model, IEEE/ACM
Trans. Comput. Biol. Bioinf., 20(1), 421-431 (2023).
Cui, Y.; Wang, Z.; Wang, X.; Zhang, Y.; Zhang, Y.; Pan, T.; Zhang,Z.; Li, S.; Guo, Y.; Akutsu, T.; Song, J., SMG: Self-Supervised
Masked Graph Learning for Cancer Gene Identification, Briefings
Bioinf., 24(6), bbad406 (2023).
Shiota, K.; Akutsu, T., Multi-Shelled ECIF: Improved Extended
Connectivity Interaction Features for Accurate Binding Affinity
Prediction, Bioinf. Adv, 3(1), vbad155 (2023).
Matsuda, K.; Shirakami, A.; Nakajima, R.; Akutsu, T.; Shimono,M., Whole-Brain Evaluation of Cortical Microconnectomes,
Eneuro, 10(10), ENEURO.0094-23.2023 (2023).
Cao, Y.; Pi, W.; Lin, C.-Y.; Münzner, U.; Ohtomo, M.; Akutsu, T.,
Common Attractors in Multiple Boolean Networks, IEEE/ACM
Trans. Comput. Biol. Bioinf., 20(5), 2862-2873 (2023).
Li, F.; Wang, C.; Guo, X.; Akutsu, T.; Webb, G. I.; Coin, L. J. M.;
Kurgan, L.; Song, J., ProsperousPlus: A One-Stop and Comprehensive Platform for Accurate Protease-Specific Substrate
Cleavage Prediction and Machine-Learning Model Construction,
Briefings Bioinf., 24(6), bbad372 (2023).
[Others]
Akutsu, T.; Nacher, J., Complex Networks and Control Theory,
Morikita Publishing Co., Ltd., 1-206 (2023).
― Bio-knowledge Engineering ―Wang, X.; Sun, L.; Nguyen, C. H.; Mamitsuka, H., Multiplicative
Sparse Tensor Factorization for Multi-View Multi-Task Learning,
Front. Artif. Intell. Appl., 372, 2560-2567 (2023).
Qu, W.; You, R.; Mamitsuka, H.; Zhu, S., DeepMHCI: An Anchor
Position-Aware Deep Interaction Model for Accurate MHC-I
Peptide Binding Affinity Prediction, Bioinformatics, 39(9), btad551(2023).
Nguyen, D. A.; Nguyen, C. H.; Mamitsuka, H., Central-Smoothing
Hypergraph Neural Networks for Predicting Drug_Drug Interactions, IEEE Trans. Neural Networks Learn. Syst., 1-6 (2023).
Liao, Z.; Xie, L.; Mamitsuka, H.; Zhu, S., Sc2Mol: A ScaffoldBased Two-Step Molecule Generator with Variational Autoencoder and Transformer, Bioinformatics, 39(1), btac814 (2023).
HAKUBI PROJECT— Optoelectronic Energy Recycling and Quantum Cooperative
Effects in Semiconductor Nanostructures —Sekiguchi, F.; Sakamoto, M.; Nakagawa, K.; Tahara, H.; Sato, S.
A.; Hirori, H.; Kanemitsu, Y., Enhancing High Harmonic Generation in GaAs by Elliptically Polarized Light Excitation, Phys.
Rev. B, 108, 205201 (2023).

ICR ANNUAL REPORT, 2023

105

INTERNATIONAL RESEARCH COLLABORATIONS[Australia]
Monash University, Monash Biomedicine Discovery Institute[Austria]
Vienna University of Technology, Photonics Institute[China, P.R.]
Chinese Academiy of Science, Changchun Institute of Applied
Chemistry
Fudan University, School of Computer Science
Fudan University, School of Pharmacy
Peking University, Peking-Tsinghua Center for Life Sciences,
College of Life Sciences
ShanghaiTech University, School of Information Science andTechnology
South China University of Technology, School of Computer
Science and Engineering
The University of Hong Kong, Department of Mathematics
Tsinghua University, Department of Chemistry[Croatia]Ruđer Bošković Institute, Division of Organic Chemistry andBiochemistry[Czech Republic]
The Czech Academy of Sciences, Institute of Hydrobiology[Finland]
Aalto University, Department of Computer Science[France]
Centre National de la Recherche Scientifique[India]Birbal Sahni Institute of Palaeosciences
CSIR-National Institute for Interdisciplinary Sciences and Technology, Chemical Science and Technology Division
Indian Institute of Technology, Bombay, Department of Metallurgical Engineering & Materials Science Including Corrosion Science & Engineering[Israel]
Ben-Gurion University of the Negev, Department of Computer
Science[Italy]University of Naples “Federico II”, Department of Chemical Sciences[Norway]
University of Bergen, Department of Biology[Romania]
Extreme Light Infrastructure-Nuclear Physics (ELI-NP), Horia
Hulubei National Institute for R&D in Physics and Nuclear
Engineering (IFIN-HH)
National Institute for Laser, Plasma and Radiation Physics[Sri Lanka]
University of Colombo, Departmentof Chemistry[Taiwan]National Yang Ming Chiao Tung University, Institute of Bioinformatics and Systems Biology[Thailand]
Chiang Mai University, Center of Excellence in Materials Scienceand Technology

French Alternative Energies and Atomic Energy Commission(CEA), Laboratoire de Physiologie Cellulaire & Végétale

Chiang Mai University, Faculty of Science[Germany]
European Molecular Biology Laboratory

Mahidol University, Faculty of Science

Heinrich-Heine-Universität Düsseldorf, Institut für Theoretische
Chemie und Computerchemie
Karlsruhe Institute of Technology, Institute of Organic Chemistry
Technische Universität Dresden, Dresden Integrated Center for
Applied Physics and Photonic Materials (IAPP)

106

INTERNATIONAL RESEARCH COLLABORATIONS

Maejo University, School of Renewable Energy

Naresuan University, Faculty of Science
Thailand Center of Excellence in Physics, Ministry of Higher
Education, Science, Research and Innovation
Thailand National Metal and Materials Technology Center,
Powder Metallurgy Research and Development Unit

[the U.K.]
Durham University, OEM Research Group, Department of
Physics
University of St. Andrews, EaStCHEM School of Chemistry
University of St Andrews, Organic Semiconductor Centre,
EaStCHEM School of Chemistry[the U.S.]
Stony Brook University, Department of Materials Science andChemical Engineering
The Ohio State University, Department of Microbiology &Department of Civil, Environmental, and Geodetic Engineering
University of South Florida, College of Marine Science
University of Michigan, Department of Chemical Engineering
University of California San Diego, Scripps Institution of
Oceanography*The list shows the institutions with which papers are co-authored.

ICR ANNUAL REPORT, 2023

107

SELECTED GRANTSDIVISION OF SYNTHETIC CHEMISTRY― Organoelement Chemistry ―TOKITOH, Norihiro
New Main Group Element Chemistry and Materials Science
Based on Heavy Aryl Anions
Grant-in-Aid for Scientific Research (S)26 June 2019–31 March 2024
YAMADA, Hiroko
Development Organic Donor-Acceptor Materials for the Cotrolof Dynamic Exciton
Grant-in-Aid for Transformative Research Areas (A)19 November 2020–31 March 2025
YAMADA, Hiroko
Development of Pi-Expanded Aromatic Compounds Based on
Precursor Approach
Grant-in-Aid for Scientific Research (A)1 April 2020–31 March 2023
MATSUO, Kyohei
Development of n-Type Organic Semiconductors Using Main
Group Element Complexes of Tetrabenzoporphyrins
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025
YAMAUCHI, Mitsuaki
Control of Helical Arrangement of Quantum Dots Using Supramolecular Templates and the Realization of Circular Polarized
Emission
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2025
YUKIMOTO, Mariko
Creation of Tautomerizable Heavy Amides Compounds
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2024
― Structural Organic Chemistry ―MURATA, Yasujiro
Developments of Nanoscale Laboratory by SophisticatedChemical Transformation of Fullerenes
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2026

MURATA, Yasujiro
Synthesis and Photophysical Properties of Novel Chiral Nanocarbons
Grant-in-Aid for Challenging Research (Exploratory)
30 June 2023–31 March 2025
HIROSE, Takashi
Investigation on Chiral Molecular Wire Properties Based on
pi-Extended Helical Molecules
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2026
HIROSE, Takashi
Creation of Chiral Molecular Functions Based on Precise
Arrangement of Helical pi-Conjugated Molecules
PRESTO, (Precursory Research for Embryonic Science andTechnology), JST
1 December 2020–31 March 2024
HASHIKAWA, Yoshifumi
Creation of Experimental Hydration Models Based on Sphericalpi-Systems
Grant-in-Aid for Scientific Research on Innovative Areas(Research in a Proposed Research Area)
1 April 2022–31 March 2024
― Synthetic Organic Chemistry ―OHMIYA, Hirohisa
Flexible Conversion of Complex and Bulky Molecules Using
Light Energy
Grant-in-Aid for Transformative Research Areas (A)1 April 2023–31 March 2028
OHMIYA, Hirohisa
Radical-Enabled Organocatalytic Chemistry
Grant-in-Aid for Scientific Research (A)5 April 2021- 31 March 2025
NAGAO, Kazunori
Catalytic Generation of Sulfur Cation Radical Species by Dynamic
Exciton and its Application to Bond Formation Reactions
Grant-in-Aid for Transformative Research Areas (A)10 September 2021–31 March 2023
NAGAO, Kazunori
Catalytic Generation of Carbocation without Acids and the Application to Bond Formation Reactions
Grant-in-Aid for Early-Career Scientists
1 April 2021–31 March 2024

Abbreviations and Acronyms
AMED : Japan Agency for Medical Reserach and Development
JSPS : Japan Society for the Promotion of Science
JST : Japan Science and Technology Agency
MEXT : Ministry of Education, Culture, Sports, Science and Technology
NEDO : New Energy and Industrial Technology Development Organization
METI : Ministry of Economy, Trade and Industry

108

SELECTED GRANTS

― Advanced Inorganic Synthesis ―TERANISHI, Toshiharu
Nanoscale Element Replacement Science: Structural Trans­
formation of Nanocrystalline Phases and Development of Novel
Functions
Grant-in-Aid for Scientific Research (S)26 June 2019–31 March 2024
TERANISHI, Toshiharu
Synthesis of Unprecedented Ordered Alloy Nanoparticles andDevelopment of Their Structure-Specific Properties
Grant-in-Aid for Challenging Research (Exploratory)
28 June 2019–31 March 2023

SATO, Ryota
Principle Study of Plasmonic Ordered Nanoalloys
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2027
MATSUMOTO, Kenshi
Inter-Element Miscibility Driven Rearrangement from Disordered to Long-Range Ordered Alloy Structures
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2025
DIVISION OF MATERIALS CHEMISTRY― Chemistry of Polymer Materials ―TERANISHI, Toshiharu
Creation of Unprecedented Nanomaterials by Precious Arrangement of Atomic Layers and Crystal Phase
CREST (Core Research for Evolutional Science and Technology),
JST
1 November 2021–31 March 2027

TSUJII, Yoshinobu
Development of Next-Generation Monolithic Membrane Columns
to Reduce Biopharmaceutical Purification Costs
Go-Tech Project, The Small and Medium Enterprise Agency,
METI
1 August 2023–1 May 2025

TERANISHI, Toshiharu
Fabrication of Unprecedented Alloy Cathode Catalysts
Development of Technologies for Realizing a Hydrogen Society,
NEDO
31 July 2020–31 March 2025

TSUJII, Yoshinobu
Development of High-Performance Sliding Parts by Imparting
Concentrated Polymer Brushes (CPB) and Their Application to
Equipment
A-STEP (Adaptable and Seamless Technology Transfer Program
through Target-driven R&D), JST
1 December 2020–31 March 2023

TAKAHATA, Ryo
Modeling of Defects and Exploration of Novel Materials byUsing Cadmium Chalcogenide Clusters with Definite Structures
Grant-in-Aid for Early-Career Scientists
1 April 2021–31 March 2024
TAKAHATA, Ryo
Development of Precise Control Methods for Nanomaterials with
Multi-Functions
Uncharted Territory Challenge 2050, NEDO
1 November 2021–30 September 2026
TAKEKUMA, Haruka
Controlling Plasmonic Properties of Novel Ordered Alloy
Nanoparticles
Grant-in-Aid for Early-Career Scientists
1 April 2023–31 March 2026
TAKEKUMA, Haruka
Creation of Platinum-Based Bimetallic Nanoparticles
IRCCS Young Scientists Co-Creation Proposal Research Fund
1 April 2022–31 March 2023

TSUJII, Yoshinobu
Hierarchical Understanding and Control of Wear Phenomena on
Ultra-Low Friction Polymer Brushes
CREST (Core Research for Evolutional Science and Technology),
JST
1 October 2021–31 March 2027
TSUJII, Yoshinobu
Development of Next-Generation Ship-Bottom Coating Films
and Coating Processes for Energy Saving and Reduced Environmental Impact
Environment Research and Technology Development Fund,
ERCA (Environmental Restoration and Conservation Agency)
1 April 2022–31 March 2024
KINOSE, Yuji
Synthesis of Asymmetric Polymer-Brush-Modified Nanorods andFormation of Their Ordered Structures
Grant-in-Aid for Early-Career Scientists
1 April 2023–31 March 2026

SARUYAMA, Masaki
Chemical Synthesis and Exploration of Concerted Optical
Properties of Anisotropic Three-Dimensional Quantum Dot
Superlattices
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2027

ISHIDA, Koichiro
Construction of Polysaccharide-Nanofiber Monolayers by Interfacial Architectonics and Creation of Novel Scaffold Functions
Grant-in-Aid for JSPS Research Fellow
8 April 2022–31 March 2024

SARUYAMA, Masaki
Synthesis and Function of Diverse Three-Dimensional Inorganic
Nanoparticle Superstructures
Grant-in-Aid for Challenging Research (Exploratory)
30 July 2020–31 March 2023

― Polymer Controlled Synthesis ―SARUYAMA, Masaki
Creation of Strucutre Specific Reaction Fields through SelfAssembly of Nanocrystals
FOREST (Fusion Oriented Research for Disruptive Science andTechnology), JST
1 April 2022–31 March 2025

YAMAGO, Shigeru
Development of New Fabrication Methods of Polymer Materials
Based on the Structurally Controlled Hyperbranched Polymers
Grant-in-Aid for Scientific Research (S)5 July 2021–31 March 2026

ICR ANNUAL REPORT, 2023

109

YAMAGO, Shigeru
International Research Center for Basic Organic Device Chemistryby True Integration of Synthesis and Device
Core-to-Core Program, JSPS
1 April 2022–31 March 2026

MORIOKA, Naoya
Exploring Control of Localized Spins Based on Electrical Spin
Injection in Silicon Carbide
Grant-in-Aid for Research Activity Start-up
30 August 2021–31 March 2023

TOSAKA, Masatoshi
Aggregation Structure of Hyper-branched Block Copolymers in
Solution
Grant-in-Aid for Scientific Research (C)1 April 2021–31 March 2024

HERBSCHLEB, Ernst David
Enhanced Quantum Sensing with a Nitrogen-Vacancy Centre as
Gateway to the Electron Spin of Phosphorus
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2024

KAYAHARA, Eiichi
Creation of New Cyclic π-Conjugated Molecules for Realizationof High Density Conjugation
Grant-in-Aid for Transformative Research Areas (A)10 September 2021–31 March 2023

NISHIKAWA, Tetsuri
Investigation of Carrier Transport Mechanism for PhotocurrentDetected Magnetic Resonance on Color-Center Spins in Silicon
CarbideGrant-in-Aid for Research Activity Start-up
31 August 2023–31 March 2025

KAYAHARA, Eiichi
Pioneering Chemistry of Totally Conjugated Cyclic Polymers
FOREST (Fusion Oriented Research for Disruptive Science andTechnology), JST
1 April 2022–31 March 2025

― Nanospintronics ―― Inorganic Photonics Materials ―ONO, Teruo
Ferrimagnetic Spintronics and Device Application
Grant-in-Aid for Scientific Research (S)31 August 2020–31 March 2025

MIZUOCHI, Norikazu
Research of Quantum Sensing by Advanced Control of the
Quantum State of NV Center in Diamond
Grant-in-Aid for Scientific Research (A)5 April 2021–31 March 2024

ONO, Teruo
Unraveling the Mechanism of Superconductive Diode Effect andCreating Non-Volatile Superconductive Diode
Grant-in-Aid for Challenging Research (Pioneering)
9 July 2021–31 March 2024

MIZUOCHI, Norikazu
Development of Innovative Sensor Systems by Highly Sophisticated Control of Solid Quantum Sensors
Q-LEAP (Quantum Leap Flagship Program), MEXT
1 November 2018–31 March 2028

ONO, Teruo
Development of 3D Magnetic Memory
CREST (Core Research for Evolutionary Science and Technology),
JST
1 October 2021–31 March 2025

MIZUOCHI, Norikazu
Innovations Medicine and Life Sciences through the Applicationof Quantum Technology
Q-LEAP (Quantum Leap Flagship Program), MEXT
1 April 2020–31 March 2030

SHIOTA, Yoichi
Polarization Control of Spin Wave Spin Current and Its Device
Application
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2025

MIZUOCHI, Norikazu
Highly Sensitive Quantum Sensing Microscope Development
Research for Elucidating Biological Phenomena
CREST (Core Research for Evolutional Science and Technology),
JST
1 October 2023–31 March 2029

HISATOMI, Ryusuke
Creation of Highly Efficient Optical Photon-Microwave Conversion Using Disk-Shaped Ferromagnetic Thin Films
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2024

MIZUOCHI, Norikazu
Development of an Ultra-Sensitive Quantum Magnetic Sensing
System That Enables High Sensitivity NMR without the Need for
Cooling
A-STEP (Adaptable and Seamless Technology Transfer Program
through Target-driven R&D), JST
1 October 2023–31 March 2027
MORIOKA, Naoya
Study of Spin-Optical-Charge Dynamics of Defects in Silicon
Carbide for Highly Efficient Electrical Spin Readout
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2025

110

SELECTED GRANTSHISATOMI, Ryusuke
Opto-Spin-Mechanics Using Surface Acoustic Waves
PRESTO (Precursory Research for Embryonic Science andTechnology), JST
1 November 2020–31 March 2024
KARUBE, Shutaro
Development of Novel Spin Current Control Technology Basedon Exchange Interaction
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2025
KARUBE, Shutaro
Creation of Innovative Information Carrier Devices by Multifunctional Spin Oxides
PRESTO (Precursory Research for Embryonic Science andTechnology), JST
1 October 2022–31 March 2025

NARITA, Hideki
Control of Superconductivity by Noncollinear Magnetism
Grant-in-Aid for Early-Career Scientists
1 April 2021–31 March 2024
NARITA, Hideki
Creation of Innovative Quantum Control Technology Using
Hybrid Superconductors
PRESTO (Precursory Research for Embryonic Science andTechnology), JST
1 October 2023–31 March 2025
DIVISION OF BIOCHEMISTRY― Biofunctional Design-Chemistry ―FUTAKI, Shiroh
Intracellular Fate of Extracellular Fine Particles and the Control
System
CREST (Core Research for Evolutionary Science and Technology),
JST
1 October 2018–1 March 2024
IMANISHI, Miki
Biological Function of Non-Canonical Nucleic Acids
Grant-in-Aid for Transformative Research Areas (B)
23 August 2021–31 March 2024
KAWAGUCHI, Yoshimasa
Intracellular Delivery and Phase Separation Control of Antibodies
Based on Coa
Strategic Basic Research Programs ACT-X, JST
1 April 2022–31 March 2025

KATO, Mariko
Study on the Involvement of Phosphoinositides in Pollen Germination
Grant-in-Aid for Scientific Research (C)1 April 2021–31 March 2025
― Chemical Biology ―UESUGI, Motonari
Development of Artificial Chaperones
Grant-in-Aid for Transformative Research Areas (A)16 June 2022–31 March 2024
UESUGI, Motonari
Chemical Biology of Cellular Self-Assemblies
Grant-in-Aid for Scientific Research (A)1 April 2022–31 March 2025
UESUGI, Motonari
Designer Melanin for Analyzing and Controlling Cells
Grant-in-Aid for Challenging Research (Exploratory)
9 July 2021–31 March 2023
UESUGI, Motonari
Intracellular Analysis of LLPS Status
Grant-in-Aid for Challenging Research (Exploratory)
30 June 2023–31 March 2025
UESUGI, Motonari
Asian Chemical Biology Intiative
Core-to-Core Program, JSPS
1 April 2022–31 March 2025

HIROSE, Hisaaki
Search for Peptides that Promote Internalization and Endoplasmic
Release of Extracellular Vesicles
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025

UESUGI, Motonari
PD-1 Blockade Caner Immunotherapy Combined with Small
Molecule Activators of T Cell Fatty Acid Oxidation
P-PROMOTE (Project for Promotion of Cancer Research andTherapeutic Evolution), AMED
20 May 2022–31 March 2024

― Chemistry of Molecular Biocatalysts ―UESUGI, Motonari
Grand Design Platform and Database for the Development of
Innovative Adjuvant and Vaccine Carrier
Program on R&D of New Generation Vaccine Including New
Modality Application, AMED
1 July 2022–31 March 2027

MASHIGUCHI, Kiyoshi
Investigation of the Cytochrome P450 Enzyme Family Involvedin the Biosynthesis of Non-Canonical Strigolactones
Grant-in-Aid for Scientific Research (B)1 April 2019–31 March 2023
MASHIGUCHI, Kiyoshi
Investigation of the Physiological Significance of the Structural
Diversity of Strigolactones
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2028
― Molecular Biology ―AOYAMA, Takashi
Roles of Phosphoinositid Signaling in Plant Cell Morphogenesis
Grant-in-Aid for Scientific Research (B)1 April 2021–31 March 2024
TSUGE, Tomohiko
Molecular Mechanism Governing Plant Plasticity through PremRNA 3’UTR Regulation
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025

SATO, Shinichi
Understanding Cellular Function with Short RNAs and Small
Molecules
Grant-in-Aid for Scientific Research (B)1 April 2020–31 March 2023
SATO, Shinichi
New Technologies for RNA Structural Regulation that Enables
the Control and Analysis of Cellular Function
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2026
SATO, Shinich
A New Oligonucleotide Therapeutics that Induces a Cooperative
RNA G-Quadruplex Formation for Gene Silencing
Grant-in-Aid for Challenging Research (Pioneering)
9 July 2021–31 March 2025

ICR ANNUAL REPORT, 2023

111

PERRON, Amelie
Live and Let Die: Orchestrating Aggregation of Eye Pigmentswith Organic Molecules
Grant-in-Aid for Scientific Research (C)1 April 2023–31 March 2026
ABO, Masahiro
Development of Self-Assembling Chemicals which Have
Chaperone Activity in Live Cells
Grant-in-Aid for Scientific Research (C)1 April 2021–31 March 2024
TAKEMOTO, Yasushi
Exploration of Radical-Sensitive Signal Peptide
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025
TAKEMOTO, Yasushi
Understanding and Application of Radical-Sensitive Peptide
Takeda Science Foundation
1 September 2021–31 May 2024
TAKEMOTO, Misao
Mechanistic Analysis for the Immune Activation of T Cells by
Covalent Natural Compounds
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025
DIVISION OF ENVIROMENTAL CHEMISTRY― Molecular Materials Chemistry ―KAJI, Hironori
Material Design Based on Dynamic Excition and their Applications
Grant-in-Aid for Transformative Research Areas (A)19 November 2020–31 March 2025
SHIZU, Katsuyuki
A Unified Theory of Electronic Transition Rate Constants forHigh Throughput Materials Screening
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025
SUZUKI, Katsuaki
Spatiotemporal Analysis of Dynamic Exciton by Solid-State NMR
Grant-in-Aid for Transformative Research Areas (A)19 November 2020–31 March 2025
TANAKA, Hiroyuki
Development of Multiple-Resonance Thermally Activated
Delayed Fluorescent Molecules with Excellent Circularly Polarized Luminescence Property
Grant-in-Aid for Challenging Research (Exploratory)
1 July 2023–31 March 2025
― Hydrospheric Environment Analytical Chemistry ―SOHRIN, Yoshiki
Ocean Section Diagnosis on the Basis of Stoichiometry andStable Isotope Ratios of Trace Metals
Grant-in-Aid for Scientific Research (A)1 April 2019–31 March 2023
TAKANO, Shotaro
Isotopic Analysis for Estimating the Sources of Particulate Trace
Metals in the Ocean
Grant-in-Aid for Early-Career Scientists
1 April 2020–31 March 2023

112

SELECTED GRANTSZHENG, Linjie
Speciation and Sectional Distribution of Al, Mn, Fe, Co, Ni, Cu,
Zn, Cd, and Pb in the South Pacific and Indian Oceans
Grant-in-Aid for Early-Career Scientists
1 April 2021–31 March 2024
― Chemistry for Functionalized Surfaces ―HASEGAWA, Takeshi
Evolution of Near-Infrared Spectroscopy for Materials Structure
Analysis: Development of NIR-MAIRS
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2026
HASEGAWA, Takeshi
Innovation in Control of Physical Properties of Polymer ThinFilm Materials by Micro-Morphology Analysis of Amorphous
Grant-in-Aid for Challenging Research (Exploratory)
9 July 2021–31 March 2024
MORI, Taizo
Dynamic Response of Molecular Machines at the Air-Water
Interface Using Second Harmonic Generation
Grant-in-Aid for Scientific Research (C)1 April 2023–31 March 2028
SHIOYA, Nobutaka
Visualization of Monolayer Structures Specifically Formed by
Functional Organic Materials at the Substrate Interface
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2025
― Molecular Microbial Science ―KURIHARA, Tatsuo
Molecular Basis for Generation of the Diversity of Bacterial
Membrane Phospholipid Acyl Chains and Mechanisms Underlying
Their Physiological Functions
Grant-in-Aid for Scientific Research (B)1 April 2021–31 March 2024
KURIHARA, Tatsuo
Dissection of the Molecular Basis of Membrane Vesicle Biogenesis
and Construction of an Extracellular Platform for Substance
Production by Using a Hyper-Vesiculating Bacterium
Grant-in-Aid for Challenging Research (Pioneering)
30 July 2020–31 March 2023
KURIHARA, Tatsuo
Enzymatic Manipulation of Biomembrane Lipids to Enhance
Cellular Function
Grant-in-Aid for Challenging Research (Exploratory)
30 June 2023–31 March 2025
KAWAMOTO, Jun
Elucidation of Molecular Mechanism of Extracellular Membrane
Vesicle Production by Bacteria and Its Application
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2026
KAWAMOTO, Jun
A Novel Platform for Functional Nanoparticle -the Synthesis
Mechanism of Unique Outer-Membrane Vesicles of Bacteria and
Its ApplicationGrant-in-Aid for Scientific Research (C)1 April 2020–31 March 2023

KAWAMOTO, Jun
Exploration and Application of Outer Membrane Vesicle-Producing
Bacteria as a Foundation for New Nano-Material Development
Fund for the Promotion of Joint International Research (International Collaborative Research)
8 September 2023–31 March 2027
OGAWA, Takuya
Study on the Metabolic Conversion of Omega-3 Polyunsaturated
Fatty Acids through a Reconsideration of Beta-Oxidation Pathway
Grant-in-Aid for Scientific Research (C)1 April 2021–31 March 2024
DIVISION OF MULTIDISCIPLINARY CHEMISTRY― Polymer Materials Science ―TAKENAKA, Mikihito
4D Analysis of Grazing Incidence Scattering to Reveal Adhesion
Processes at the Adhesive Interface
Mirai Program, JST
1 November 2018–31 March 2028

WAKAMIYA, Atsushi
Pb-Free Perovskite Solar Cells Consisting of Sn
Mirai Full-scale R&D Project, JST
1 April 2022–31 March 2027
WAKAMIYA, Atsushi
Development of Practical Technology for Perovskite Solar
Module with High Installation Flexibility
Green Innovation Fund Projects ,NEDO
27 December 2021–31 March 2026
WAKAMIYA, Atsushi
Development of Film-Type Perovskite Solar Module with High
Degree of Freedom Design
Development of Technologies to Promote Photovoltaic Power
Generation as a Primary Power Source, NEDO
13 July 2020–31 March 2025
MURDEY, Richard
Ageing and Passivation Effects in Perovskite Solar Cells
Grant-in-Aid for Scientific Research (C)1 April 2019–31 March 2023

OGAWA, Hiroki
Non-Equilibrium MI Scheme Shortens Future Material Development
Feasibility Study Program, NEDO
10 May 2023–31 March 2025

NAKAMURA, Tomoya
Two-Dimensionally Expanded pi-Systems for High-Performance
Tin Perovskite Solar Cells
Grant-in-Aid for Early-Career Scientists
1 April 2021–31 March 2023

OGAWA, Hiroki
Development of a Recycled Plastics Databank to Improve theCircurability
SIP, ERCA (Environmental Restoration and Conservation Agency)
1 October 2023–31 March 2028

TRUONG, Minh Anh
Development of Multipodal Hole-Transporting Monolayer
Materials for High Performance Perovskite Solar Cells
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2024

― Molecular Rheology ―ADVANCED RESEARCH CENTER FOR BEAM SCIENCE― Particle Beam Science ―MATSUMIYA, Yumi
Molecular Dynamics of Associative Polymers and Its Experimental
Validation: Effect of Dissociation Equilibrium on Entanglement
Relaxation Modes
Grant-in-Aid for Scientific Research (B)1 April 2021–31 March 2024
SATO, Takeshi
Development of Coarse-Grained Molecular Model for Predicting
Dynamics of Entangled Associating Polymers
Grant-in-Aid for Early-Career Scientists
1 April 2021–31 March 2024
SATO, Takeshi
A New Fluid Science for Non-Newtonian/Non-Uniform/NonEquilibrium Flows
PRESTO (Precursory Research for Embryonic Science andTechnology), JST
1 October 2022–31 March 2026
― Molecular Aggregates ―WAKAMIYA, Atsushi
Fundamental Chemical Research for Efficirnt Lead Free Perovskite
Solar Cells
Grant-in-Aid for Scientific Research (A)5 April 2021–31 March 2024

WAKASUGI, Masanori
Precise Measurement of Charge Density Distribution of Sn
Unstable Isotopes by Advanced Innovative SCRIT Electron
Scattering
Grant-in-Aid for Scientific Research (S)12 April 2023–31 March 2028
WAKASUGI, Masanori
Development of Stationary Target for Unstable Nuclei for Application to Research of Nuclear Reaction
Grant-in-Aid for Challenging Research (Pioneering)
30 July 2020–31 March 2023
WAKASUGI, Masanori
Development of RFQ-Type Isobar Filters Leading Inovative
Research on Unstable Nuclear Reactions
Grant-in-Aid for Challenging Research (Pioneering)
30 June 2023–31 March 2026
TSUKADA, Kyo
Isotope Dependences of Nuclear Charge Distributions andNeutron Radius by Electron Scattering
Grant-in-Aid for Scientific Research (A)1 April 2020–31 March 2025
OGAWARA, Ryo
Development of Internal Active Target for Beam Recycle
Techniques
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2024

ICR ANNUAL REPORT, 2023

113

OGAWARA, Ryo
Development of Beam Recycle Techniques for Advanced Researchon Nuclear Reactions with Rare RI
FOREST (Fusion Oriented Research for Disruptive Science andTechnology), JST
1 April 2023–31 March 2030
TONGU, Hiromu
Mapping System Using High-Speed Scanning in Cryogenic
Environment for Superconductor State Inspection
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025
― Laser Matter Interaction Science ―TOKITA, Shigeki
Development of Mid-Infrared High-Power Ultrashort Pulse Lasers and Its Application to Soft-Matter Micro-Processing
Grant-in-Aid for Scientific Research (B)1 April 2021–31 March 2024
TOKITA, Shigeki
The Power Laser DX Platform
Project for Promoting Public Utilization of Advanced Research,
MEXT
1 April 2021–31 March 2026
TOKITA, Shigeki
Formation of Ultrashort Femtosecond Pulses in the Mid-Infrared
Range Based on Iron-Doped Chalcogenides for Problems of
Nonlinear Optics of Media with a Reduced Dimension
Bilateral Joint Research Projects, JSPS
1 April 2021–31 March 2023
TOKITA, Shigeki
Development of an Industrial Femtosecond Laser
Intensive Support Program for Young Promising Researchers,
NEDO
15 January 2021–31 March 2023
TOKITA, Shigeki
Pioneering of a High-Intensity Coherent X-Ray Generation
Method Using an Ultrahigh-Intensity Mid-Infrared Laser
Matsuo Academic Research Grant, MATSUO Foundation
1 December 2023–31 March 2025
TOKITA, Shigeki
Development of Compact and Highly Efficient Mid-Infrared
Femtosecond Lasers
Research Grant, The Asahi Glass Foundation
1 April 2023–31 March 2025
TOKITA, Shigeki
Development of High-Intensity Mid-Infrared Lasers for Realizing
Compact Coherent X-Ray Sources
Research Grant, Research Foundation for Opto-Science andTechnology
1 January 2023–31 December 2024
TOKITA, Shigeki
Micromachining of Transparent Resin Using Mid-Infrared Pulsed
LasersAMADA Research and Development Grant, The AMADAFoundation
26 September 2020–31 March 2024

114

SELECTED GRANTSTOKITA, Shigeki
Development of High-Intensity Coherent X-Ray Generation Method
Supporting Program for Unique Exploratory Investigation Team
Studies (SPIRIT2), Kyoto University
1 April 2023–31 March 2025
OKAZAKI, Daiki
Exploring Multispectral Peak Light Source Technology Using
High-Intensity Lasers
Grant-in-Aid for Research Activity Start-up
31 August 2023–31 March 2025
OKAZAKI, Daiki
Development of High Power 3 Micron Fiber Lasers Pumped by
Laser Diodes
Resarch Support 2023, Yamada Science Foundation
4 August 2023–31 March 2026
OKAZAKI, Daiki
Research on a Novel Burst Pulse Generation Technique for
Efficient Femtosecond Laser Processing
Encouragement Research Grant, The Amada Foundation
1 October 2023–31 March 2026
OKAZAKI, Daiki
Development of Wavelength-Tunable Mid-IR Burst Pulse Lasers
Basic Science Research Projects, The Sumitomo Foundation
7 December 2023–30 November 2026
KANAI, Tsuneto
Development of a Mid-IR Laser Driven X-Ray Spectroscopic
System for Zeptosecond Atomic, Molecular, Particle Physics
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2026
KANAI, Tsuneto
Optical Poling-Based Microfabrication of Plastic Materials Using
Carrier Wave Envelope Phase Stabilized, Wavelength Tunable
Mid-Infrared Femtosecond Lasers
AMADA Research and Development Grant, The AMADAFoundation
1 October 2022–31 March 2026
KANAI, Tsuneto
Development of a Mid-IR Laser-Driven X-Ray Source for
Zeptosecond Particle Physics Matsuo Academic Research Grant,
MATSUO Foundation
1 December 2022–31 March 2024
KANAI, Tsuneto
Development of High Power Mid-IR Lasers for Zeptosecond
Particle Physics
SPIRITS 2022
1 April 2022–31 March 2023
HASHIDA, Masaki
Operando Measurements Using Advanced Beams to Study the
Mechanism of Fine Structure Formation
Basic Foundational Research: “Next-Generation Laser” Projects,
Q-LEAP (Quantum Leap Flagship Program), MEXT
1 April 2020–31 March 2029
― Electron Microscopy and Crystal Chemistry ―HARUTA, Mitsutaka
Visualization of Electron Orbital Using TEM
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2025

INTERNATIONAL RESEARCH CENTER FOR ELEMENTSSCIENCE― Synthetic Organotransformation ―NAKAMURA, Masaharu
Iron-Catalyzed Cross Coupling: Quantum Control on Multi-Spin
Pathways
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2026
ISOZAKI, Katsuhiro
Triple-Layer Core-Shell Metal Nanocluster Synthesis Driven byInterligand Hydrogen Bonds
Grant-in-Aid for Challenging Research (Exploratory)
30 June 2023–31 March 2025
DOBA, Takahiro
Iron-Catalyzed Carbon–Heteroatom Bond Formation Reactions
through pi-Plane Activation
Research Activity Start-up
31 August 2023–31 March 2025
DOBA, Takahiro
Development of Iron-Catalyzed Carbon–Heteroatom Bond Formation Reactions
Research grant from the Institute of Synthetic Organic Chemistry
1 October 2023–30 September 2024
NAKAGAWA, Yuka
Pioneering Catalytic Reactions for Direct Synthesis of Functional
Polymers from Wood
Grant-in-Aid for Early-Career Scientists
1 April 2023–31 March 2026
NAKAGAWA, Yuka
Development of Molecular Complex Catalysts for Converting
Wood into Functional Materials
PRESTO, (Precursory Research for Embryonic Science andTechnology), JST
30 September 2023–30 March 2027
MINEO, Keito
Integrated Scenario Analysis of Environmental Impacts andEconomic Potential of Forest Management and Wood Uses
Daigas Research Grants for Young Researchers, Kyoto University
Open Innovation Institute
8 February 2023–7 February 2024
IMAI, Makiko
Analysis of Lignin Decomposition Mechanism That Produce
Nanosheet Cellulose
Grant-in-Aid for Early-Career Scientists
1 April 2023–31 March 2026

― Organometallic Chemistry ―OHKI, Yasuhiro
Synthesis and Reactions of Bio-Inspired Molecular MetalHydride Compounds
Grant-in-Aid for Scientific Research on Innovative Areas(Research in a Proposed Research Area)
1 April 2021–31 March 2023
OHKI, Yasuhiro
Synthesis of Iron-Containing Cluster Complexes and Reducing
Reactions with Multiple Metals
Grant-in-Aid for Scientific Research (B)1 April 2023–31 March 2026
OHKI, Yasuhiro
Synthesis of Metal-Nanoclusters of Iron Group Metals
Grant-in-Aid for Challenging Research (Exploratory)
30 July 2020–31 March 2023
OHKI, Yasuhiro
Fuel Regeneration from CO2 by Grid-Aligned Biomimetic
Catalysts on Functionalized Silica
Grant-in-Aid for JSPS Fellows
8 March 2023–31 March 2025
OHKI, Yasuhiro
Electron Transfer Networks of Transition Metal Cluster Complexes
for Catalytic Applications
CREST (Core Research for Evolutional Science and Technology),
JST
1 October 2021–31 March 2027
TANIFUJI, Kazuki
CO2/CO Reduction into Short-Chain Hydrocarbons Promoted by
Cuboidal Metal-Sulfur Clusters
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025
TANIFUJI, Kazuki
Structure-Function Relationships of a Fe/Mo-S-C Cluster Uniqueto N2-Reducing Enzymes
Grant-in-Aid for Research Activity Start-up
30 August 2021–31 March 2023
HIGAKI, Tatsuya
Creation of Novel Cluster Nanomagnets with Strong ExchangeInteractions
Grant-in-Aid for Early-Career Scientists
1 April 2023–31 March 2025

― Advanced Solid State Chemistry ―HIGAKI, Tatsuya
Atomically Precise Synthesis of Iron-Group Metal Nanoclusters
to Probe the Origin of Superparamagnetism
Grant-in-Aid for Research Activity Start-up
31 August 2022–31 March 2024

SHIMAKAWA, Yuichi
Construction of Physical Property Correlation Based on Entropy
and Creation of New Thermal Control Materials
Grant-in-Aid for Scientific Research (S)12 April 2023–31 March 2028

IZU, Hitoshi
Catalytic System for Carbon Dioxide Reduction Utilizing Sequence
Control of Cubane-Type Complexes
Grant-in-Aid for Early-Career Scientists
1 April 2023–31 March 2025

SHIMAKAWA, Yuichi
Exploration of Functional Transition-Metal Oxides and Their
Structure-Property Relationships
AdCORP (Advanced International Collaborative Research
Program), JST
1 April 2023–31 March 2027

ICR ANNUAL REPORT, 2023

115

― Nanophotonics ―KANEMITSU, Yoshihiko
Fusing Nanomaterials and Strong Electric Field Nonlinear Optics
for New Advances in Photonics
Grant-in-Aid for Specially Promoted Research
23 April 2019–31 March 2024
KANEMITSU, Yoshihiko
Optical Responses of Ordered Alloy Nanomaterials and Nanomaterial-Based Superstructures
CREST (Core Research for Evolutional Science and Technology), JST
1 October 2021–31 March 2027
HIRORI, Hideki
Phononic Strong Coupling by THz Metamaterial and Its Applications to Material Control
Grant-in-Aid for Scientific Research (B)1 April 2021–31 March 2025
YUMOTO, Go
Development of Polarization-Resolved Pump-Probe Microscopy
and Study of Rashba Spin-Optoelectronics in Atomically Thin
Materials
Grant-in-Aid for Early-Career Scientists
1 April 2023–31 March 2025
TAHARA, Hirokazu
Spatial and Temporal Super-Resolution Method for Revealing
Quantum Cooperative Processes in Semiconductor Nanostructures
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2026
TAHARA, Hirokazu
Development of Nanostructured Semiconductor-Photon Coupled
Systems for Giant Optoelectronic Amplification
Grant-in-Aid for Challenging Research (Exploratory)
30 June 2023–31 March 2025
TAHARA, Hirokazu
Development of Efficient Optoelectronic Devices with Quantum
Cooperativity in Nanomaterial Superstructures
PRESTO (Precursory Research for Embryonic Science andTechnology), JST
1 October 2023–31 March 2027
BIOINFORMATICS CENTER― Chemical Life Science ―OGATA, Hiroyuki
Virus-Driven Clockwork in Lower Tropic Level Marine Ecosystem
and Its Impact on the Ocean
Grant-in-Aid for Scientific Research (S)5 July 2021–31 March 2026
OGATA, Hiroyuki
Aggregate-Biosphere: Unveiling Hidden Regulatory Processes in
the Oceanic Carbon Cycle
Grant-in-Aid for Scientific Research (S)26 June 2019–31 March 2024
OGATA, Hiroyuki
Ecology of Giant viruses Inhabiting the Aphotic Zone of the Sea
Grant-in-Aid for Scientific Research (A)1 April 2022–31 March 2026

116

SELECTED GRANTS

OGATA, Hiroyuki
Molecular Ecological Mechanism of Bloom Disintegration by
Viral Infection
Grant-in-Aid for Scientific Research (A)1 April 2022–31 March 2027
OGATA, Hiroyuki
Study of Giant Virus Ecology and Virus-Host Interaction in
Aquatic Environments
Grant-in-Aid for Scientific Research (B)1 April 2020–31 March 2023
OGATA, Hiroyuki
Virus-Host Database
Grant-in-Aid for Publication of Scientific Research Results(Database)1 April 2020–31 March 2025
ENDO, Hisashi
Viral Infection and Its Control Mechanisms of Marine Plankton
Communities as Revealed by Dissolved Ribosomal RNA
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2026
ENDO, Hisashi
Plankton Communities Contributing to Marine Biological Pumpon the Global Scale
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2025
ENDO, Hisashi
Experimental Investigation of the Effects of Phytoplankton Diversity on Ecosystem Functioning in the Ocean
Grant-in-Aid for Early-Career Scientists
1 April 2019–31 March 2023
ENDO, Hisashi
A Novel Dynamics Analysis of Marine Plankton Based on Genetic
Information in the Dissolved Fraction of Seawater
CREST (Core Research for Evolutional Science and Technology),
JST
1 October 2023–31 March 2029
ENDO, Hisashi
A Novel Dynamics Analysis of Marine Plankton Based on Genetic
Information in the Dissolved Fraction of Seawater
PRESTO (Precursory Research for Embryonic Science andTechnology), JST
1 October 2023–31 March 2027
OKAZAKI, Yusuke
Unveiling the Organic Matter Dynamics Functioning in Lake
Hypolimnion
Grant-in-Aid for Scientific Research (A)1 April 2022–31 March 2026
OKAZAKI, Yusuke
Elucidating the Molecular Heterogeneity of Dissolved Organic
Matter That Governs Its Long-Term Persistence
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2025
OKAZAKI, Yusuke
Microbial Nitrogen Pump: Bacterial Semi-Labile Dissolved
Organic Nitrogen as a Nutrient Transport Pathway in Aquatic
Systems
Grant-in-Aid for Scientific Research (B)1 April 2021–31 March 2024

OKAZAKI, Yusuke
Who is the Host of Uncultivated Viruses? Linking Viral and
Bacterial Genomes in the Environment
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2025

MAMITSUKA, Hiroshi
Latent Data Structure Estimation through Integrating Diverse
Data
Grant-in-Aid for Scientific Research (B)1 April 2022–31 March 2025

OKAZAKI, Yusuke
Developing a High-Resolution Eco-Genomics Platform throughInter-Lake Comparisons
FOREST (Fusion Oriented Research for Disruptive Science andTechnology), JST
1 April 2023–31 March 2030

MAMITSUKA, Hiroshi
Developing Machine Learning Based Bioinformatics to Decipher
Hidden Biology of Depression Symptoms
Grant-in-Aid for JSPS Fellows
13 November 2020–31 March 2023

OKAZAKI, Yusuke
Challenging Dry Questions in Environmental Microbiology andVirology from Wet
Kyoto University 125th Anniversary Fund Kusunoki 125
13 September 2021–31 March 2025
HIKIDA, Hiroyuki
Diversity of Giant Virus Infection Strategy
Grant-in-Aid for Early-Career Scientists
1 April 2022–31 March 2025

NGUYEN, Hao Canh
Machine Learning on Large Graphs
Grant-in-Aid for Scientific Research (C)1 April 2018–31 March 2023
NGUYEN, Hao Canh
Machine Learning for Structure-Rich Data-Scarce Domains
Grant-in-Aid for Scientific Research (C)1 April 2022–31 March 2025

HIKIDA, Hiroyuki
Development of Novel Gene Engineering Technology Utilizing
Giant Viruses
Strategic Basic Research Programs ACT-X, JST
1 October 2022–31 March 2025
― Mathematical Bioinformatics ―AKUTSU, Tatsuya
Advanced Studies and Developments on Discrete Preimage
Problems
Grant-in-Aid for Scientific Research (A)1 April 2022–31 March 2027
AKUTSU, Tatsuya
Analysis and Control of Steady States of Multiple Biological
Networks
Grant-in-Aid for Challenging Research (Exploratory)
30 June 2022–31 March 2025
TAMURA, Takeyuki
Algorithms for Metabolic Network Design for Producing Useful
Substances
Grant-in-Aid for Scientific Research (B)1 April 2020–31 March 2025
MORI, Tomoya
Establishment of the Method for Biological Tissue Domain
Estimation and Analysis Based on Spatial Omics Data
Grant-in-Aid for Scientific Research (C)1 April 2023–31 March 2026
― Bio-knowledge Engineering ―MAMITSUKA, Hiroshi
Development of Next Generation Plastic Materials Based on
Structurally Controlled Hyperbranched Polymers
Grant-in-Aid for Scientific Research (S)5 July 2021–31 March 2026

ICR ANNUAL REPORT, 2023

117

THESESAKAGI, Chika
D Sc, Kyoto University“Study on Ribosome-related Gene Expression during Light Germination of Arabidopsis thaliana”
Supervisor: Prof AOYAMA, Takashi
23 March 2023

MAEHARA, Yoshiki
M Sc, Kyoto University“Beam Dynamics of RUNBA and Developments of Dorrection
Devices, EDC and ADC”
Supervisor: Prof WAKASUGI, Masanori
23 March 2023

FUNADA, Shinsaku
D Sc, Kyoto University“Magnetic Resonance Measurements in Ferrimagnets with
Compensation Points”
Supervisor: Prof ONO, Teruo
17 January 2023

NGUYEN, Anh Duc
D Pharm Sc, Kyoto University“Establishing Advanced Deep Learning Models for Predicting
Drug Side Effects”
Supervisor: Prof MAMITSUKA, Hiroshi
23 March 2023

HIRAI, Yusuke
D Pharm Sci, Kyoto University“Cytosolic Protein Delivery Using Lipid Nanoparticles”
Supervisor: Prof FUTAKI, Shiroh
24 March 2023

NISHIKAWA, Tetsuri
D Eng, Kyoto University“Development of Electrical Detection Techniques of Color Centers’
Spins in Diamond and Silicon Carbide”
Supervisor: Prof MIZUOCHI, Norikazu
23 March 2023

HU, Shuaifeng
D Sc, Kyoto University“Surface Modifications of Mixed Tin-Lead Halide Perovskite
Films for Solar Cells”
Supervisor: Prof WAKAMIYA, Atsushi
23 March 2023
IMAMURA, Yuji
D Eng, Kyoto University“Advanced Control of Polymer Structure Based on Multiple
Control in Radical Polymerization”
Supervisor: Prof YAMAGO, Shigeru
23 May 2023
JIANG, Yuhan
D Eng, Kyoto University“Development of Practical Organotellurium-Mediated Radical
Polymerization Based on Polymerization and Separation in a
Two-phase System”
Supervisor: Prof YAMAGO, Shigeru
23 May 2023
JIN, Shuyu
D Med, Kyoto University“Self-Assembling Small-Molecule Adjuvants as Antigen NanoCarriers”
Supervisor: Prof UESUGI, Motonari
23 March 2023
KOSUGI, Yoshihisa
D Sci, Kyoto University“Synthesis and Evaluation of Transition Metal Oxides Exhibiting
Caloric Effects”
Supervisor: Prof. SHIMAKAWA, Yuichi
23 March 2017
LI, Ruiming
D Inf, Kyoto University“Analysis of Biological Networks by Graph Theory-Based
Methods”
Supervisor: Prof AKUTSU, Tatsuya
23 March 2023

118

THESESNISHIO, Kosuke
D Med, Kyoto University“Magnetic Control of Cells by Chemical Fabrication of Melanin”
Supervisor: Prof UESUGI, Motonari
23 March 2023

THE 123RDICR ANNUALSYMPOSIUM

SEMINARSMEETINGS ANDSYMPOSIA

THE 123RD ICR ANNUAL SYMPOSIUM(1 December 2023)
ORAL PRESENTATIONOKAZAKI, Daiki (Laser Matter Interaction Science)“Development of Mid-Infrared Femtosecond Lasers and Their
Applications”
YAMAUCHI, Mitsuaki (Organoelement Chemistry)“Construction of Highly Ordered Quantum Dots and Organic
Molecules with a Supramolecular Approach”
KINOSE, Yuji (Chemistry of Polymer Materials)“Anchoring Property on Zero Azimuthal Anchoring Surface”— ICR Award for Young Scientists —TRUONG, Minh Anh (Molecular Aggregates)“Tripodal Triazatruxene Derivative as a Face-on Oriented HoleCollecting Monolayer for Efficient and Stable Inverted Perovskite
Solar Cells”
MENG, Lingjie (Chemical Life Science)“Mirusviruses Link Herpesviruses to Giant Viruses”— ICR Award for Graduate Students —CHO, Kenichi (Nanophotonics)“Exciton-Phonon and Trion-Phonon Couplings Revealed by
Photoluminescence Spectroscopy of Single CsPbBr3 Perovskite
Nanocrystals”

POSTER PRESENTATIONS
LW : Laboratory Whole Presentation
LT : Laboratory Topic

GE : General Presentation— Organoelement Chemistry —LW“Research Topics of Organoelement Chemistry Laboratory”

GE NISHINO, Ryohei; TOKITOH, Norihiro; YAMADA, Hiroko;
MIZUHATA, Yoshiyuki“Development of a Single Germanium Atom Transfer Reagent”— Structural Organic Chemistry —LW“Recent Research Activities in Structural Organic Chemistry”

GE HU, Weizhe; MURATA, Yasujiro; HIROSE, Takashi“Non-Linear Molecular Spring Properties of a Dibenzo[c,u][7]helicene Derivative Derived from Intramolecular Non-CovalentInteractions”— Synthetic Organic Chemistry —ZHANG, Zhenya (Nanophotonics)“Generation of Third-Harmonic Spin Oscillation from Strong
Spin Precession Induced by Terahertz Magnetic near Fields”

GE NAKAGAWA, Masanari; NAGAO, Kazunori; OHMIYA,
Hirohisa“A Light-Driven Hybrid Catalysis Enabling Construction of
Azetidine via C-H Bond Activation”

TOH, Kohei (Chemical Biology)“Chemoproteomic Identification of Blue-Light-Damaged Proteins”— Advanced Inorganic Synthesis —— ICR Grants for Promoting Integrated Research —LW“Research Topics of Advanced Inorganic Synthesis”

HISATOMI, Ryusuke (Nanospintronics)“Study of Phonon Angular Momentum Using Impulsive Stimulated
Raman Scattering”

GE ZHU, Lingkai; SARUYAMA, Masaki; TERANISHI, Toshiharu“Synthesis of 3D Ag Nanoparticle Superlattices and Their
Structure-Specific Functions”

ABO, Masahiro (Chemical Biology)“Development of Chemical Tools for Magnetic Manipulation of
Biomolecules”— Chemistry of Polymer Materials —TAKAHATA, Ryo (Advanced Inorganic Synthesis); ISOZAKI,
Katsuhiro (Synthetic Organotransformation)“Development of a Connection-Number-Controlling Method for
Nanoparticles”
HIKIDA, Hiroyuki (Chemical Life Science)“Transcriptome Analysis in Virus-Infected Non-Model Organisms”
TRUONG, Minh Anh (Molecular Aggregates)“Elucidating the Structure of Hole Collecting Monolayer in
Perovskite Solar Cell”

120

THE 123RD ICR ANNUAL SYMPOSIUM

LW “Recent Researches in Chemistry of Polymer Materials
Laboratory”
GE SEIKE, Yuki; KINOSE, Yuji; TSUJII, Yoshinobu“Synthesis of Concentrated Polymer Brushes with Larger
Thickness via Improved Livingness in Surface-Initiated Controlled Radical Polymerization”

— Polymer Controlled Synthesis —— Hydrospheric Environment Analytical Chemistry —GE TONG, Tianxiang; KIBUNE, Masato; TOSAKA, Masatoshi;
MATSUMIYA, Yumi; WATANABE, Hiroshi; YAMAGO, Shigeru“Synthesis of Structurally Controlled Dendritic Hyperbranched
Polyacrylates by TERP and Their Rheological Properties”

LW “Reveal the Ocean by Using Trace Elements and Their
Isotopes”

GE MARU, Kosuke; ZHENG, Leshang; KAYAHARA, Eiichi;
YAMAGO, Shigeru“Synthesis of Cyclic π-conjugated Oligomers by the Insertion of
Alkynes and Isocyanides into Cycloparaphenylene Metal
Complexes”— Inorganic Photonics Materials —LW“Research Introduction of Inorganic Photonics Materials”— Nanospintronics —GE KAWARAZAKI, Ryo“Spin Injection into a Superconductor without Inversion Symmetry”
GE TAGA, Kotaro; KOMIYAMA, Haruka; MATSUMOTO,
Hiroki; HISATOMI, Ryusuke; NARITA, Hideki; KARUBE,
Shutaro; MORIYAMA, Takahiro; SHIOTA, Yoichi; ONO, Teruo“Frequency and Magnetic Field Angle Dependences of the
Coupling between Spin Wave and Surface Acoustic Wave in
NiFe Thin Film”— Biofunctional Design-Chemistry —“Recent Research in the Laboratory of Biofunctional DesignChemistry”

GE UEKI, Ryuta; ZHENG, Linjie; TAKANO, Shotaro; SOHRIN,
Yoshiki“Distribution of Zirconium, Hafnium, Niobium, and Tantalum in
the Indian Ocean”— Chemistry for Functionalized Surfaces —GE ARAKI, Taisuke; SAKO, Nobuaki; SHIOYA, Nobutaka;
YAJIMA, Tomoko; HASEGAWA, Takeshi“Understanding of Physical Properties of Perfluoroalkanes byInfrared Spectroscopy Using Recrystallized Compounds”
GE SUGIMOTO, Emi; SHIOYA, Nobutaka; OKA, Takayuki;
HASEGAWA, Takeshi“Control of Crystal Orientation of Organic Semiconductors with
Alkyl Side Chains in Thin Films by Low-Temperature Deposition”— Molecular Microbial Science —GE INOUE, Hiromu; KAWANO, Kenichi; KAWAMOTO, Jun;
OGAWA, Takuya; KURIHARA, Tatsuo“Diversity of Bacterial Extracellular Membrane Vesicles Determined by Nucleic Acid Content and the Genes Involved in Their
Production”— Polymer Materials Science —LW

GE ASAMI, Yuri; OTONARI, Kenko; IMANISHI, Miki; FUTAKI,
Shiroh“Sequence-Specific Manipulation of RNA Methylation by
Engineering of an RNA Demethylase, ALKBH5”

LW“Polymer Materials Science”—Molecular Rheology —LW“Molecular Rheology Laboratory”— Chemistry of Molecular Biocatalysts —— Molecular Aggregates —LW “Introduction of Chemistry of Molecular Biocatalysts Laboratory”

LW— Molecular Biology —LW“Research of Molecular Biology Laboratory”— Chemical Biology —LW“Create New World of Bioactive Synthetic Molecules”— Molecular Materials Chemistry —LW“Molecular Materials Chemistry”“Research in Molecular Aggregation Analysis Laboratory”

GE MURDEY, Richard; MATSUSHIGE, Yuko; OHASHI, Noboru;
TRUONG, Minh Anh; NAKAMURA, Tomoya; WAKAMIYA,
Atsushi“Accelerated Testing of Perovskite Solar Cells”— Particle Beam Science —LW“Particle Beam Science Lab.”— Laser Matter Interaction Science —LW “Introduction of the Laser Matter Interaction Science Laboratory”

GE ISHIHARA, Kuraudo; KAJI, Hironori“Molecular Orientation and Mobility Prediction of Organic
Deposited Films by Multiscale Simulation”

ICR ANNUAL REPORT, 2023

121

— Electron Microscopy and Crystal Chemistry —LW “Research Activities in Division of Electron Microscopy and
Crystal Chemistry”— Atomic and Molecular Structures —LW“Introduction of Atomic and Molecular Structures Laboratory”— Synthetic Organotransformation —LW“Introduction of Synthetic Organotransformation Laboratory”— Advanced Solid State Chemistry —LW“Research Reports in Advanced Solid State Chemistry”— Organometallic Chemistry —LW“Recent Research Topics of Organometalic Chemistry Group”— Nanophotonics —LW“Recent Research Topics of Nanophotonics Group”— Mathematical Bioinformatics —LT MU, Lixuan; SONG, Jiangning; MORI, Tomoya; AKUTSU,
Tatsuya“DiCleave: a Deep Learning Model for Predicting Human Dicer
Cleavage Sites”— Bio-knowledge Engineering —LT NGUYEN, Can Hao“Theoretical Study of Convex Clustering Algorithm”

122

THE 123RD ICR ANNUAL SYMPOSIUM

SEMINARSProf AYELE, Belay
Department of Plant Science, University of Manitoba, Manitoba,
Canada“Insights into the Role of Jasmonate in Regulating Seed Dormancy
in Wheat”
1 Jun 2023

Assist Prof FUKUI, Norihito
Graduate School of Engineering, Nagoya University, Nagoya,Japan“Creation of Novel π-Conjugated Molecules with the Search
Space inside the Molecular Skeleton”
27 July 2023

Prof. BLACKBURN, Jeffrey
National Renewable Energy Laboratory (NREL), the U.S.
“Mixed-Dimensionality Nanoscale Heterojunctions for Energy
Harvesting and Opto-Electronic Technologies”
24 November 2023

Dr. GALBIATI, Massimo
Institute of Agricultural Biology and Biotechnology, CNR, Milano,
Italy“Deciphering the Transcriptional Regulation of Stomatal Activity”
22 November 2023

Assoc Prof BROERE, Daniël L. J.
Institute for Sustainable and Circular Chemistry, Utrecht University, the Netherlands“Are Two Better than One? The Exploration of “Expanded
Pincer” Ligands in Combination with Group 8 Metals in Hydrocarbon Activation and Homogeneous Catalysis”
10 August 2023

Specially Appointed Prof HIGUCHI, Yoshiki
University of Hyogo, Hyogo, Japan“Elemental Cycling Strategy by Organisms”
30 October 2023

Prof CUMMINS, Christopher C.
Department of Chemistry, Massachusetts Institute of Technology,
the U.S.
“Phosphorus-Element Bond-Forming Reactions from Pn to
Phosphinidene Group Transfer”
15 September 2023
Prof DESTARAC, Mathias
Université Toulouse 3 Paul Sabatier, France“Tailored Polyvinylamines by RAFT”
2 August 2023
Prof EMORI, Satoru
Virginia Polytechnic Institute and State University, Virginia, theU.S.
“Damping and Spin-Orbit Torques in Vertically Graded Fe-Ni
Films”
9 May 2023
Prof FAN, Xin
University of Denver, Colorado, the U.S.
“Spin Current Generation in Ferromagnetic Metals”
3 March 2023
Assoc Prof FERRIER, Robert C., Jr.
Michigan State University, Michigan, the U.S.
“Facile Epoxide Polymerizations with Sustainable Aluminum
Catalysts”
18 January 2023
Prof FINOCCHIO, Giovanni
University of Messina, Italy“High Performance Spintronic Devices for Microwave Technology
and Computing”
26 May 2023
Prof FRATH, Denis
Laboratoire de Chimie, ENS Lyon, CNRS, France“Photoredox Control of Electron-Responsive and Conductive
Supramolecular Materials Based on Viologens”
16 November 2023

Prof HILLEBRANDS, Burkard
TU Kaiserslauterun , Germany“Advances in Coherent Magnonics”
24 May 2023
Assoc Prof HINGAMP, Pascal
Aix-Marseille University, France“Environmental Genomics: Bioinformatics Methods to Estimate
Biodiversity from Metagenomes”
20 March 2023
Assoc Prof HINGAMP, Pascal
Aix-Marseille University, France“Hands-on Introduction to Bioinformatics”
4-8, 11-12, 25 September 2023
Prof HO, Rong-Ming
National Tsing Hua University, Taiwan“Well-Ordered Nanonetwork Materials from Block Copolymer
Templates for Metamaterial Applications”
7 July 2023
Dr HO, Tung-Yuan
Research Center for Environmental Changes, Academia Sinica,
Taiwan“The Solubility and Deposition Flux of East Asian Aerosol
Metals in the East China Sea: The Effects of Aeolian Transport
Processes”
11 September 2023
Dr HSIEH, Chih-Chiang
Research Center for Environmental Changes, Academia Sinica,
Taiwan“The Contribution of East Asian Aerosol Metals in the Ocean:
Sources, Transformation Processes and Deposition Fluxes”
2 October 2023
Prof HWANG, Chanyong
Korea Research Institute of Standards and Science, Korea, R“Magnetic Skyrmion”
17 October 2023
Prof ILIES, Laurean
RIKEN, Saitama, Japan“Catalyst Design for Selective and Efficient Reactions”
2 June 2023

ICR ANNUAL REPORT, 2023

123

Dr IMADA, Hiroshi
Surface and Interface Science Laboratory, RIKEN, Wako, Japan“Developing Various Dimer Systems Based on Single-Molecule
Manipulation Techniques and Evaluation of Their Optical
Properties”
19 October 2023
Prof ISOBE, Hiroyuki
The University of Tokyo, Tokyo, Japan“Organic Chemistry: From the Basics to the Current Style”
1 June 2023
Prof ISOBE, Hiroyuki
The University of Tokyo, Tokyo, Japan“Phenine Nanocarbon Molecules”
2 June 2023
Prof ISOBE, Hiroyuki
The University of Tokyo, Tokyo, Japan“Organic Chemistry: From Structure and Synthesis to Boundaries”
20 November 2023
Prof ISOBE, Hiroyuki
The University of Tokyo, Tokyo, Japan“Supramolecular Science of Nanocarbon Molecules”
21 November 2023
Dr. KAKSIS, Edgar Vienna
Vienna University of Technology, Austria“Scaling of Peak and Average Power in Femtosecond Ytterbium
Amplifiers”
9 March 2023
Prof KIHARA, Daisuke
Purdue University, the U.S.
“Building and Validating Biomolecular Structure Models forcryo-EM Maps Using Deep Learning”
28 June 2023
Prof KOBAYASHI, Toshihide
Centre National de la Recherche Scientifique (CNRS), France“Regulatory Proteins for the Asymmetric Distribution of
Sphingomyelin”
25 May 2023
Prof LIAN, Tianquan
Department of Chemistry, Emory University, Georgia, the U.S.
“Structure and Dynamics at Metal Electrode/Electrolyte Interface
Probed by Insitu Electrochemical Surface Enhanced/Selective
Vibrational Spectroscopy”
8 May 2023
Prof. LIN, Hao-Wu
National Tsing Hua University, Taiwan“Perovskite Optoelectronic Devices: Solar Cells and Beyond”
5 July 2023
Prof LIU, Hongbin
The Hong Kong University of Science and Technology, China
P.R.
“Diversity and adaptation of Synechococcus in Estuarine Waters”
20 January 2023
Prof MARGETIĆ, DavorRuđer Bošković Institute, Croatia“The Reactivity of Guanidine Substituted Furans and Pyrroles in
Cycloaddition Reactions”
11 September 2023

124

SEMINARSProf MARTIN-VACA, Blanca
Paul Sabatier University and Centre national de la Recherche
Scientifique, France“Cooperative Catalysis with Pd and Pt Pincer Complexes”
3 March 2023
Prof MINDIOLA, Daniel J.
Department of Chemistry, University of Pennsylvania, the U.S.
“New Developments in Low-Valent and Early Transition Metal
Ions, Metal-Ligand Multiple Bonds, and Catalytic Reactions
Involving Methane”
11 July 2023
Prof NAKAI, Madoka
Tokyo University of Agricultural and Technology, Tokyo, Japan“Frontiers of Insect Virus Research Contributing to Pesticide
Reduction and Training the Next Generation of Researchers”
27 December 2023
Prof NAKANO, Ken et al.
Yokohama National University, Yokohama, Japan“SRT Basic Seminar (Series of 8 Sessions)”
6-30 July 2023
Prof NGUYEN, Thuc-Quyen
Department of Chemistry & Biochemistry, University of California
Santa Barbara, California, the U.S.
“Designing Organic Semiconductors for Energy Generation andInfrared Sensing”
11 December 2023
Dr NISHIMURA, Masaki
Technology Research Institute of Osaka Prefecture, Osaka, Japan“A Researcher’s Life in Public Testing Research Institute: between
Industry, Technology, and Science”
26 May 2023
Prof NOMURA, Nobuhiko
Faculty of Life and Environmental Sciences, University ofTsukuba, Ibaraki, Japan“Emergence of Bacterial Community Formation and Sociality”
30 January 2023
Prof OGASAWARA, Masamichi
Department of Natural Science, Graduate School of Science andTechnology, Tokushima University, Tokushima, Japan“Enantioselective Catalytic Synthesis of Chiral Transition Metal
Complexes”
27 January 2023
Dr. OGAWA, Satoshi
Botany and Plant Sciences Faculty, University of California,
Riverside, California, the U.S.
“Molecular Basis for Host Tropism in Orobanchaceae Parasitic
Plants”
21 November 2023
Prof. POPMINTCHEV, Tenio
University of California San Diego, the U.S.
“Quantum Optics Meets Strong Field Physics: Novel Regimes of
Coherent X-Ray Generation with Strong Electron Correlation
Dynamics and Attosecond Rabi Oscillations”
12 December 2023
Prof RIVARD, Eric
Department of Chemistry, University of Alberta, Alberta, Canada“Frustrated Lewis Pair (FLP) Chelation for Main Group Materials
Synthesis”
8 March 2023

Assist Prof RUBIO, Vicente
Centro Nacional de Biotecnologia, CSIC, Madrid, Spain“Dangerous Liaisons: COP1 and DET1 Regulatory Loops inControlling Plant Development”
12 October 2023

Lect TASHIRO, Yosuke
College of Engineering, Shizuoka University, Shizuoka, Japan“Diversity of Bacterial Membrane Vesicles and the Molecular
Basis for the Regulation of Vesicle Production”
17 May 2023

Assist Prof SADIQ, Nausheen W.
Department of Chemistry, Mount Royal University, Canada“Evaluating Risk to Human Health Associated with Microplastics,
Contaminated Soils, Waters and a Variety of Food Samples at the
Elemental Level Using ICP-MS”
9 March 2023

Prof TCHORZEWSKI, Marek
Department of Molecular Biology, Institute of Biological Sciences,
Maria Curie-Sklodowska University, Poland“Ribosome: A Multifaceted Nano-Machine”
28 June 2023

Prof SAITO Hiroaki
Atmosphere and Ocean Research Institute, The University ofTokyo, Tokyo, Japan“Prochlorococcus in the Indian Ocean”
20 January 2023
Assoc Prof SAKAI, Munetoshi
Ibaraki University, Ibaraki, Japan“Functional Evaluation Method for Dynamic Wettability on Solid
Surfaces”
28 August 2023
Assoc Prof SARAKONSRI, Thapanee
Department of Chemistry, Faculty of Science, Chiang Mai University, Thailand“Enhanced Electrochemical Performance of Nanocomposite
Anode Materials with High Energy Density, Ultrafast-Charging
and Stable Cycling for High- Efficiency Li-Ion Batteries”
5 June 2023
Prof. SASAMORI, Takahiro
University of Tsukuba, Ibaragi, Japan“Introduction of Single Crystal X-ray Diffraction Analysis -Key
Points to Consider When Facing Analytical Challenges-”
14 June 2023
Dr SATO, Yuya
Environmental Management Research Institute, National Institute of Advanced Industrial Science and Technology (AIST),
Tsukuba, Ibaraki, Japan“Emergence of Unique Biological Functions Triggered byMicrobe-Driven Interspecific Relationships”
17 November 2023

CNRS Research Fellow THILI, Anis
University of Lyon 1, France“Valorization of Greenhouse Gases: CO2, SF6 and Beyond”
30 October 2023
Prof TOKUYAMA, Hidetoshi
Tohoku University, Miyagi, Japan“Novel Oxygen Oxidation Reaction and Unprotected Peptide
Dimerization and its Application to Alkaloid Synthesis”
21 November 2023
Assist Prof TSUCHIDO, Yoshitaka
Faculty of Science Division I, Tokyo University of Science,
Tokyo, Japan“Synthesis and Functions of Cyclic π-Conjugated Compounds
via Macrocyclic Gold Complexes”
26 May 2023
Prof VAZQUEZ, ManuelSpanish National Council for Research, Spain“Cylindrical Magnetic Micro and Nanowires: from Topology
Effects of Curvature to Sensing Applications”
26 May 2023
Prof WATERMAN, Rory
University of Vermont, California, the U.S.
“Metal-Catalyzed Routes to Low-Valent Main Group Fragments”
8 May 2023
Prof WECKWERTH, Wolfram
University of Vienna, Austria“Multiomics, AI and Data-Driven Inverse Modelling - from
Environmental Sciences to Molecular Medicine”
16 November 2023

Prof SCHELER, Ulrich
Leibniz-Institut für Polymerforschung Dresden e. V., Germany“NMR Studies for Complex Polymer Materials”
30 October 2023

Prof WEITZ, Joshua
University of Maryland, the U.S.
“Marine Viral Dynamics: Lessons from an Imperfect Predator”
7 July 2023

Dr. SHI, Dongbo
Institute for Biochemistry and Biology, University of Potsdam,
Potsdam-Golm, Germany“Identification of Cambium Stem Cells and Their Dynamics”
26 July 2023

Prof WIRTH, Thomas
Cardiff University, the U.K.
“New Opportunities for Flow Electrochemistry”
27 September 2023

Prof SUNAGAWA, Shinichi
Institute of Microbiology and Swiss Institute of Bioinformatics
ETH Zurich, Germany“The Ocean Microbiome as a Treasure Trove for Novel Taxa,
Enzymes and Bioactive Compounds”
25 July 2023
Prof TABOR, Alethea
Department of Chemistry, University College of London, the U.K.
“Liposome-Based Theragnostic Nanoparticles for Cancer Imaging, Nucleic Acid and Drug Delivery”
5 September 2023

Prof YAMAKOSHI, Yoko
Department of Chemistry and Applied Biosciences, ETH Zurich,
Zurich, Switzerland“Water-Soluble Fullerene Materials and Their Photosensitising
Activity”
5 December 2023
Prof. ZHANG, Deqing
Institute of Chemistry, Chinese Academy of Sciences, China P.R.
“New Conjugated Molecules for Organic and Polymeric Semiconductors”
11 December 2023

ICR ANNUAL REPORT, 2023

125

MEETINGS AND SYMPOSIAInternational Workshop on Bioinformatics and Systems
Biology (IBSB)
Organized by MAMITSUKA, Hiroshi
17-21 January 2023 (Berlin, Germany)
Future Drug Discovery Empowered by Chemical Biology
Organized by UESUGI, Motonari
21-22 February 2023 (Nara, Japan)
ACBI 2023 Toba Meeting
Organized by UESUGI, Motonari
22-24 February 2023 (Mie, Japan)
Spin-RNJ Symposium 2022
Organized by ONO, Teruo
20 March 2023 (Kyoto, Japan)
NII Shonan Seminar, NO.179 Computational Metabolomics
and Machine Learning
Organized by MAMITSUKA, Hiroshi
8-11 May 2023 (Kanagawa, Japan)
The 19th Akabori Conference
Organized by FUTAKI, Shiroh
16-20 May 2023 (Shiga, Japan)
10th Pacific Symposium on Radical Chemistry (PSRC-10)
Organized by YAMAGO, Shigeru
4-9 June 2023 (Kyoto, Japan)
The 1st Kyoto-SKKU Workshop
Organized by WAKAMIYA, Atsushi
5 June 2023 (Kyoto, Japan)
RURSS Unit Meeting #1 in 2023: Toward Starting Over of
PFAS Science
Organized by HASEGAWA, Takeshi
30 June 2023 (Kyoto, Japan)
Frontiers of Disease Informatics (Workshop in IIBMP 2023)
Organized by AKUTSU, Tatsuya
8 September 2023 ( Kashiwa, Japan)
1st Expert Committee on Mid-Infrared Laser Technology
Organized by TOKITA, Shigeki
27 September 2023 (Kyoto, Japan)
The First Perovskite International Research Collaboration
Center (PIRCC) Workshop
Organized by WAKAMIYA, Atsushi
3 October 2023 (Kyoto, Japan)

126

MEETINGS AND SYMPOSIA

The 2nd Seminar on International Core-to-Core Project on
Nano Carbon Device Science at Kyoto
Organized by YAMAGO, Shigeru; KAJI, Hironori; HIROSE,
Takashi
4-6 October 2023 (Kyoto, Japan)
International Mini-Symposium on Peptide Design andFunctional Extension
Organized by FUTAKI, Shiroh
11 November 2023 (Kyoto, Japan)

INDEX

NAME INDEX[A]
ABE, Reiji
8
ABO, Masahiro
26
ADACHI, Yuta
40
AKAGI, Shikoh
12
AKUTSU, Tatsuya
60
AOKI, Satoshi
50
AOKI, Takamasa
4
AOYAMA, Takashi
24
ARAKAWA, Masato
36
ARAKI, Taisuke
32, 90ASAMI, Yuri
20
AVENA, Ramon Francisco Bernardino50[B]
BABA, Nozomi
BAN, Hiroki
BANDO, Shunsuke

20
58
36

[C]
CAI, Pinghe
CHAN, Cheuk-Yin
CHAOLUMEN
CHEN, Chen
CHEN, Chien-Yu
CHEN, Jingjie
CHEN, Litian
CHEN, Tze-Shin
CHIGA, Yuki
CHO, Kenichi
CUI, Yan

30
30
6
52
40
58
50
60
10
56, 8760[D]
DAIKOKU, Yusuke
DOBA, Takahiro

56, 8850, 86

ENDO, Hisashi[E]58, 88[F]
FANG, Yue58
FARRAG, Asmaa Mostafa Abdelbari
Soliman26, 90FU, Jincheng
14
FUJI, Souta
52
FUJIHASHI, Akiko
14
FUJII, Tomomi
48
FUJIMOTO, Seitarou
12
FUJINAKA, Masatoshi
28
FUJISAKI, Yoshie
54
FUJITA, Satoki
60
FUJIWARA, Masanori
16
FUKUMOTO, Koto
50
FUKUSHIMA, Shohei
28
FUNADA, Shinsaku
83

128

NAME INDEXFUTAKI, Shiroh

20[G]
GALBIATI, Massimo
GARCIA MARTIN, Susana
GHAFOOR, Mamoona
GO, Touran
GONG, Chunjie
GOTO, Haruki
GOTO, Masato
GOTO, Yamato
GU, Jiajian

24
78
60
50
58
12
52
8
6

[H]
HAGHIR, Shahrzad
24
HAMADA, Kouki
14
HAMAMOTO, Hiroki
36
HAN, Mingjing
60
HARAMATSU, Megumi
40
HARATA, Fuyuki
40, 91HARIKI, Nene16, 90HARUTA, Mitsutaka
46
HASEGAWA, Akio
40, 91
HASEGAWA, Takeshi
32, 85HASHIDA, Masaki
44
HASHIKAWA, Yoshifumi
6
HASHIMOTO, Ruito
40
HAYASHI, Daiju
18, 90HELMS, Melanie
26
HERBSCHLEB, Ernst David 16, 82
HIGAKI, Tatsuya
54
HIGASHIMURA, Chika
56
HIKIDA, Hiroyuki
58
HINGAMP, Pascal Michel
58
HIRA, Shota
40, 86, 91
HIRANO, Toshiko
4
HIRORI, Hideki
56
HIROSE, Hisaaki
20
HIROSE, Takashi
6
HISATOMI, Ryusuke
18
HO, Yi-Ning
30
HONDA, Naoki
58
HOSHI, Yutaro
54
HOSOMI, Yu
36
HOSOYA, Tomoki
12
HSIEH, Chih-Chiang
30
HSU, Zi-Chu
60
HU, Weizhe
6, 89
HUANG, Guanglin
6[I]
ICHIKAWA, Noriya
IDA, NakaIIHOSHI, Makoto
IIJIMA, Ryo
IMADA, Hiroshi

52
20
52
18
78

IMAI, Hiroki
IMAI, Makiko
IMANISHI, Miki
IMAO, Keisuke
IMURA, Naohiro
INOUE, Hiromu
ISERI, Kenta
ISHIDA, Koichiro
ISHIHARA, Kuraudo
ISOBE, Hiroyuki
ISODA, Kumiko
ISODA, Yosuke
ISOZAKI, Katsuhiro
ITO, Mayuri
ITOH, Tomoya
IWAKI, Takuma
IWASAKI, Yasuko
IWASE, Misato
IWASHIMIZU, Chisaki
IWATA, Takahiro
IZU, Hitoshi

1450
20, 83
20
22
34
50
12
28
78
36
52
50
52
18
60
40
30
91
20
54

[J]
JANG, Heechan
JAYAKUMAR, Sanjeevi
JIANG, Yue
JIANG, Yuhan
JIANG, Zhiqian
JIN, Shuyu
JIN, Yirou
JO, Yoshiyuki

18
54
22
14, 89
62
26
10
46

[K]
KAJI, Hironori
KAKIMOTO, Ryochi
KAMEDA, Monami
KAMIYAMA, Naoya
KAN, Daisuke
KANAI, Tsuneto
KANEHISA, Minoru
KANEMITSU, Yoshihiko
KARITANI, Shu
KARUBE, Shutaro
KASAHARA, Chisato
KASAHARA, Shoma
KATO, Itsuki
KATO, Mariko
KAWABATA, Kazuhiro
KAWAGUCHI, Yoshimasa
KAWAMOTO, Jun
KAWARAZAKI, Ryo
KAWASE, Riku
KAWASHIMA, Hiroyuki
KAYAHARA, Eiichi
KIHARA, Ayako
KIKKAWA, Ayumi

28
30
12
16
52
44
78, 8256, 8736
18, 83
20
4
54
24
28
20
34
18
16, 891614
50
20

KIKUYA, Saki
KIM, Hyosuk
KIMURA, Seigo
KINOSE, Yuji
KISHIDA, NaotoKISHIDA, Takaki
KITAGAWA, Yoshifumi
KITAYAMA, KaoriKIYOKAWA, Megumi
KIYOMURA, Tsutomu
KOBAYASHI, Yuta
KOMIYAMA, Haruka
KONDO, Kazuo
KUBO, Haruki
KUGE, Kyota
KURIHARA, Tatsuo
KURIYAMA, Masashi
KUROSE, Noriko
KUSAKABE, Yu
KWON, Youngdon[L]
LATOS, Krystian
LEE, Hyunji
LI, Heqin
LI, Ruiming
LI, WeiLI, Yanbang
LI, Yufei
LIM, KyungKon
LIN, I-Ching
LIU, Chunting
LIU, Wenwen
LIU, Zhibo
LU, Siming[M]
MA, Yier
MAEDA, Yusei
MAENO, Ayaka
MAMITSUKA, Hiroshi
MANDOKORO, Tetsuma
MARU, Kousuke
MARUYAMA, Kei
MASHIGUCHI, Kiyoshi
MATSUKAWA, Kimihiro
MATSUMIYA, Yumi
MATSUMOTO, Kenshi
MATSUMURA, Hiroyuki
MATSUO, Kyohei
MATSUO, Tomotoki
MATSUOKA, Kohei
MATSUOKA, Yuto
MATSUSHIGE, Yuko
MATSUTO, Naoki
MENG, Lingjie
MICHIBATA, Junya
MINEO, Keito
MITSUI, Atsuhisa
MIYAKE, Yuki
MIYAMOTO, Yusuke
MIYAZAKI, Kazuya
MIYOSHI, Nanami

58
26
20
12
8
12
38
34
20
46, 86
18
18
16
36
10
34
20, 83, 90
32
28
38
26
10
22
60
60
14
62
38
46
60
58
6
50
60
42
28
62
18
14
56
22
12
38
10
50
4
8
30
54, 9140
38
58, 8820, 8450, 86840
8414MIZUHATA, Yoshiyuki
MIZUOCHI, Norikazu
MORI, Taizo
MORI, Tomoya
MORIKI, Yoshihito
MORIMOTO, Ryuji
MORIMOTO, Syunji
MORIOKA, Naoya
MORITA, Kouki
MU, Lixuan
MURAKAMI, Kimiya
MURAKAMI, Masanao
MURAKAMI, Sho
MURATA, Yasujiro
MURDEY, Richard
MUTO, Mitsuki

4
16
32
60
12
36
46
16
16
60
28
44
8
6
40
10

[N]
NAGAO, Kazunori
NAGASAKA, Koumei
NAGASHIMA, Chihiro
NAKAGAWA, Hiromu
NAKAGAWA, Kotaro
NAKAGAWA, Masanari
NAKAGAWA, Yuka
NAKAGAWA, Yuna
NAKAJIMA,Yuuki
NAKAMURA, Masaharu
NAKAMURA, Masaya
NAKAMURA, Rikako
NAKAMURA, Tomoya
NAKAMURA, Yuki
NAKANISHI, Yohei
NAKASHIMA, Shogo
NARITA, Hideki
NATSUME, Yayoi
NECHES, Russell Young
NEMOTO, Masaya
NEMOTO, Takashi
NGUYEN, Anh Duc
NGUYEN, Hao CanhNGUYEN, Thi TuyenNISHIJIMA, Hiroto
NISHIKAWA, Tetsuri
NISHINO, Ryohei
NOMURA, Yuki

8, 82
58
14
54
56, 878
50
20, 842850
16
8
40, 8550
36
60
18, 83
78
58
16
46
62
62
58
20
16
4
36

[O]
OBATA, Keito
ODOI, Miku
OGATA, Hiroyuki
OGATA, Yuki
OGAWA, Hiroki
OGAWA, Hiroyuki
OGAWA, Takuya
OGAWA, Tetsuya
OGAWARA, Ryo
OHASHI, Noboru
OHKI, Izuru
OHKI, Yasuhiro
OHMIYA, Hirohisa
OHORI, Masanao
OHTOMO, Masahiro

20
24
58
58
36
40
34
46
42
40
16
54, 87
8
16
60

OKA, Takayuki
OKAHARA, Ryota
OKAJIMA, Kazuki
OKAZAKI, Daiki
OKAZAKI, Yusuke
OKUDA, Shiho
OKUMURA, Kazuki
OKUMURA, Ryosuke
ONO, Teruo
ONOE, Renon
OOI, Takashi
OTA, Kenji
OTAGIRI, Yuan
OTONARI, Kenko
OYA, Ryoto

32
14
16
44
58
58
28
28
18
28
78
8
62
20, 84
8[P]
PERRON, Amelie
PETSCHNER, Peter
PIAO, Canguo
PINCELLA, Francesca

26
62
26
50

QIN, Hongwei
REN, Yongxia
REN, ZheRUBIO, Vicente

[Q]
[R]

58
28
4
24

[S]
SAITO, Ryohei
50
SAKAGUCHI, Himari
10
SAKAMOTO, Chihiro
40
SAKAMOTO, Daiki
34
SAKAMOTO, Masanori
10
SAKAMOTO, Minoru
87
SAKO, Nobuaki
32
SAMEERA, W. M. C.
78
SARUYAMA, Masaki
10, 82
SASAKI, Hiroto
58
SATO, Hinata
8
SATO, Hiroki
28, 85, 90
SATO, Ryota
10
SATO, Shinichi
26
SATO, Shinya
46
SATO, Takeshi
38
SATO, Takuya
58
SATO, Yukiya
8
SEIKE, Yuki
12
SEKIGUCHI, Fumiya
56, 87
SEKO, Tamio
36
SEO, Haruna
12
SHARKER, Komol Kanta
14
SHEN, Yufan
52
SHIBATA, Ryosuke
22
SHIBUTANI, Shotaro
8
SHIGEMATSU, Ei
16
SHIKAMI, Satoshi
50
SHIMABUKURO, Wataru
36
SHIMAKAWA, Yuichi
52, 86SHIMAZAKI, Ai
40
SHIMONO, Hiroki
8

ICR ANNUAL REPORT, 2023

129

SHIMOYAMA, Sayaka
SHIMURA, Reo
SHINYA, Hikari
SHIODA, Yudai
SHIOTA, Koji
SHIOTA, Yoichi
SHIOYA, Nobutaka
SHIRAISHI, Harunori
SHIZU, Katsuyuki
SINGH, Vaibhav Pal
SO, Frederick Tzekit
SODEOKA, Mikiko
SOHRIN, Yoshiki
SUGI, Koki
SUGIMOTO, Emi
SUGIURA, Itaru
SUN, Liangjie
SUNAMI, Kohei
SUWANAWAT, Nittikarn
SUZUKI, Hiroshi
SUZUKI, Katsuaki
SUZUKI, Shinjiro

54
6
78
34
60
18
32
36
28
26
16
78
30
18
32, 91
18
60
54
34
46
28
4

[T]
TACHIBANA, Mariko
TAGA, Kotaro
TAHARA, Hirokazu
TAKAGI, Motoshige
TAKAHASHI, Hiroyuki
TAKAHATA, Ryo
TAKANO, Shotaro
TAKARAKO, Masataka
TAKEKAWA, Yunosuke
TAKEKUMA, Haruka
TAKEMOTO, Misao
TAKEMOTO, Yasushi
TAKENAKA, Mikihito
TAKEUCHI, Kosuke
TAKEUCHI, Soshi
TAMAMOTO, Ken
TAMAO, Kohei
TAMURA, Takeyuki
TAMURA, Yukiko
TAN, Tiancheng
TANAKA, Hiroyuki
TANAKA, Kamui
TANAKA, Kanata
TANAKA, Keiji
TANG, Wei
TANIFUJI, Kazuki
TERADA, Sakahiro
TERANISHI, Kento
TERANISHI, Toshiharu
TIAN, Wu
TOBITA, Naoto
TOGISHI, Kanata
TOH, Kohei
TOKITA, Shigeki
TOKITOH, Norihiro
TOKORO, Fugo
TONG, Tianxiang
TONGU, Hiromu
TONOMURA, Asuka

42
18, 8366
60
18
1030, 85
50
8
10
26
26
36
20
50
12, 89
82
60
36
40
28
20
54
78
58
54
20
4
10
10
36
8
26, 84, 90
44, 8678, 82
18
14
42
8

130

NAME INDEXTORIGOE, Yuga
TOSAKA, Masatoshi
TOSAKI, Tomohiro
TOUSSAINT, François
TRAN, Chi Mai
TRUONG, Minh Anh
TSENG, Chih-Hsiang
TSERENDAGVA, Manchir
TSUDZUKI, Taiku
TSUGE, Tomohiko
TSUJI, Ryuki
TSUJI, Shingo
TSUJII, Yoshinobu
TSUKADA, Kyo
TUNG, Cheng-Yu

14
14
38
14
26
40, 86
18
26
34
24
40
4
12
42
60

[U]
UCHIDA, Daichi
UEDA, Kyosuke
UEHATA, Yusuke
UEKI, Ryuta
UENO, SoUESUGI, Motonari

4
50
20
30
4
26

[W]
WAKAMIYA, Atsushi
WAKASUGI, Masanori
WAN, Linbo
WANG, Yutang
WATANABE, Koh
WATANABE, Rei
WATANABE, Rin
WATANABE, Yuya
WU, Beiling
WU, Chenyao
WU, Jia-De
WU, Junyi

40
42
40
4, 89
8
52
54
22
50
60
14
58

XIA, Jun
XIA, Yan
XIE, Lingling
XIE, Xuanhao

[X]

[Y]
YAMADA, Hiroko
YAMADA, Takumi
YAMAGISHI, Yuki
YAMAGO, Shigeru
YAMAGUCHI, Shinjiro
YAMAMOTO, Ayumu
YAMASAKI, Daisuke
YAMAUCHI, Mitsuaki
YAMIN, Naila
YANADA, Mizuho
YANG, Qingwei
YANG, Yi
YANG, Yuanzheng
YASUDA, Yuka
YASUHARA, Ryo
YASUI, Kentaro
YE, Feifan
YIN, Haozhi

58
10
52
14
4
56
58
14
22
38
20
4
14
12
58
4
34
28
78
46
18
50

YOSHIDA, Riki
YOSHIDA, Satoru
YOSHIE, Shunsuke
YOSHIGAI, Toshiya
YOSHINO, Syunki
YOUN, Jae Hyung
YU, Zhaoxi
YUMOTO, GoYUNOKI, Keisuke

34
42
20
12
36
34
58
56, 8730[Z]
ZHANG, Hao
ZHANG, Liwen
ZHANG, Ruixuan
ZHANG, Yixin
ZHANG, Zheng
ZHANG, Zhenya
ZHAO, Hongda
ZHAO, Jiaying
ZHENG, Linjie
ZHONG, Yezhao
ZHU, Lingkai
ZHU, Mengshan

50
58
58
26
6
56, 8758
60
30, 8560
10, 8234, 85KEYWORD INDEX[A]
Accelerator Physics
Amorphous Materials
Analytical Chemistry
Aromatic Compound
Artificial Intelligence

42
28
30
4
62

[B]
Bacterial Cold-Adaptaion Mechanism
34
Beam Physics
42
Bioinformatics
58, 62
Bioinorganic Chemistry
54
Biosynthesis
22
Boolean Networks
60
Boron Molecule
8[C]
Channeling
Chemical Biology
Chemical Genetics
Chemical Graphs
Chemical Library
Complex Networks
π-Conjugated Systems
COP9 Signalosome
CrystalCurved π-Conjugated Molecules
Cytochrome P450
[D]
Data Mining
DiamondDielectric Spectroscopy
DNA/RNA Binding Protein
Dynamic Nuclear Polarization
Enhanced NMR[E]
EELS
Electron Linac
Elemental Mapping
Endohedral Fullerenes
Environmental Genomics
Epitaxial Thin Film Growth
Extracellular Membrane Vesicle
Extremophiles

46
26
26
60
26
60
6
24
48
14
22
62
16
38
20
28
46
42
46
6
58
52
34
34

[F]
Femtosecond Laser Spectroscopy 56
Functional Materials
6, 40
Functional Metal Oxides
52
GenomeNet

[G]

58

[H]
HAADF
Helical Structures
Heterointerface
Hierarchical StructureHigh Harmonic Generation
High Power Laser Optics
High Pressure Synthesis
Homogeneous Catalysis
Hybrid Materials

46
6
52
36
56
44
52
54
12

[I]
Immunology
26
Infrared and Raman Spectroscopy 32
Inorganic Nanomaterials
10
Intracellular Delivery
20
Iron Catalysis
50[L]
Laser Isotope Separation44
Laser Nano-Ablation Physics
44
Laser-Plasma Interaction Physics 44
Living Radical Polymerization 12, 14[M]Machine Learning
Magnetic Materials
Magnetism
Main Group Element
Marine Chemistry
Membrane Curvature
Membrane-Permeable Peptides
Mesoscopic Model
Metal Ion Recognition
Molecular Aggregation
Molecular Design and Synthesis
Molecular Evolution
Morphogenesis
mRNA Processing

62
18
18
4
30
20
20
38
30
40
40
58
24
24

[N]
Neural Networks
Nitrogen Fixation
NV Center

60
54
16

[O]
Organic Light-Emitting Diodes
Organic Semiconductor
Organic Semiconductors
Organic Synthesis
Organocatalysis
Organotransformation
Oxidation Reduction Reactions

28
4
32
14
8
50
10

Peptide Design

[P]

20

Perfluoroalkyl Compounds
Perovskite Solar Cells
Perovskites
Phospholipid Acyltransferase
Phospholipid Signaling
Photocatalysts
Photoredox Catalysis
Plant Hormone
Plasmonics
pMAIRS and MAIRS2
Polymer BrushPolymer Physics
Polymer Properties
Polymer Synthesis
Polyunsaturated Fatty Acid
Precision Polymerization
Protein Crystallography
Protein Informatics

32
40
56
34
24
10
8
22
10
32
12
36
14, 36
14
34
12
48
60

[Q]
Quantum Chemical Calculation
28
Quantum Dots
10, 56
Quantum Information Science16
Quantum Materials
16
Quantum Sensing
16[R]
Radical Reaction
Radical Species
Reactive Intermediate
Receptor
Rheology

8
6
4
22
38

[S]
Self Assembly
36
Self-Assembly
4, 26
Semiconductors
40
Signal Transduction
24
Single Photon Spectroscopy
56
Soft Matter
38
Softmatter
36
Solid State Chemistry52
Solid-State NMR
28
Spintronics
18
Stable Isotopes
30
STEM
46
Storage Ring
42
Strigolactone
22
Structural Biology
48
Structure and Function
48
Supramolecular & Superatomic
Catalysis
50
Surface and Interface Chemistry 32
Synthetic Reactions
8
Systems Biology
62

ICR ANNUAL REPORT, 2023

131

[T]
Trace Elements
Transition Metal Clusters
Tribology

30
54
12

[U]
Ultrafast Laser Physics
Unstable Nuclear Physics

44
42

Virology

[V]

58

[W]
Woody Molecular Transformation 50[X]
X-ray Crystallographic Analysis

132

KEYWORD INDEX

48