Partnering with theDepartment of Defense toProtect the Warfighter:
Investments In
National Health Security
June 30, 2022

Overview and DoD Priorities:
Chemical, Biological,Radiological and Nuclear (CBRN)
Defense Medical Priorities
Mr. Ian Watson
Deputy Assistant Secretary of Defense for
Chemical and Biological DefenseOverview and DoD Priorities:
Joint Science and Technology
Office (JSTO) Overview
LTC Barbara Cloutier
Acting Division Chief, Warfighter Integration/
Military Advisor

CBDP Enterprise

JSTO-CBD

Mature technologies
to JPEO-CBRND

CBDP mission:
Anticipate future threats & deliver capabilities thatenable the Joint Force to survive, fight & win inchemical and biological (CB)-contested environments

JPEO-CBRND

JRO-CBRN

Requirements
to JSTO-CBD

Prioritized needs

Solutions towarfighter

through a coordinated effort designed to neutralize
adversarial CB threats.

Unclassified4

JSTO-CBD Structure
Chemical and Biological Technologies Department (RD CB)

COL Timothy Greenhaw, (Acting) Director
Deputy Director, Chemical and BiologicalTechnologies Department

Research Operations
Division (CBC)Mr. Eric Lowenstein

Warfighter Integration/Military Advisor
Division (CBW)LTC Barbara Cloutier (Acting)Research Centerof Excellence Division (CBR)
Dr. Neil Jensen

Protection and Hazard Mitigation
Division (CBT)Dr. Charles Bass

Detection/Diagnostics
Division (CBA)
Dr. Richard Schoske

Digital Battlespace Management
Division (CBI)Dr. John Hannan

Vaccines/Therapeutics
Division (CBM)
Dr. Erin Reichert

Advanced and Emerging Threat
Division (CBS)Dr. Bradley Norwood

Solutions sooner rather than later …

DOMANERATE Algorithm

CBLITE Uniform
Me-Med6

Connecting to Ops

Chemical andBiological Operational
Analysis (CBOA)

Advanced Technology
Demonstration (ATD)
Leading S&T for Chem-Bio Defense

For more information, please visit us atwww.dtra.mil

Visit us – Keyword: DTRA

Download our e-book Keyword: DTRA

The Defense Threat Reduction Agency's Chemical and Biological Technologies Department serves
as the Joint Science and Technology Office within the Chemical and Biological Defense ProgramOverview and DoD Priorities:
Joint Program Executive Officefor CBRN Defense(JPEO-CBRND) Overview
Mr. Darryl Colvin
Joint Program Executive Officer

Investing at the Speed ofNeed: Novel Technologies
and Platforms to Accelerate
Drug Development

Investing at the Speed of Need: Novel Technologies
and Platforms to Accelerate Drug Development

Platforms as A New DoDParadigm
Mr. Bruce Goodwin
Joint Project Lead for CBRND
Enabling BiotechnologiesInvesting at the Speed of Need: Novel Technologies
and Platforms to Accelerate Drug Development

Generative UnconstrainedIntelligent Drug Engineering(GUIDE) Platform
Mr. Bruce Goodwin
Joint Project Lead for CBRND
Enabling Biotechnologies

Investing at the Speed of Need: Novel Technologies
and Platforms to Accelerate Drug Development

Pandemic Prevention Platform(P3)
Dr. Amy Jenkins
Defense Advanced Research Projects Agency
Biological Technologies OfficeInvesting at the Speed of Need: Novel Technologies
and Platforms to Accelerate Drug Development

Accelerated Antibodies
Mr. Dave Bailey
Joint Project Lead for CBRND
Enabling Biotechnologies

ACCELERATED ANTIBODIESInteragency initiative between DOD and HHS to establish and exercise an industry ‘development machine’to de-risk and accelerate monoclonal antibody delivery

Platform Discovery

May not be required for every mAb

Phase 1
trial

Cell line
developmentmAbdevelopment
machineMfg
Non-clinicaltesting

Accelerated Antibody Development Machine15

Investing at the Speed of Need: Novel Technologies
and Platforms to Accelerate Drug Development

Vaccine Acceleration by
Modular Progression (VAMP)
LTC Amanda Love
Joint Project Manager for CBRN Medical

VAMP MODULAR APPROACH

Modular contracting strategy with multiple options and go/no go decisions across thedevelopment pathway; allows for vaccine acceleration through full or interim capabilities, toincrease readiness against a broad class of threats, as need and funding allows.

This strategy helps vaccines accelerate through full or interim capabilities
VAMP BIO Webinar

UNCLASSIFIED

17

Investing at the Speed of Need: Novel Technologies
and Platforms to Accelerate Drug Development

Question and Answer
SessionRepurposing andRedirecting: An Alternate
Approach to Accelerating
Medical CountermeasuresRepurposing and Redirecting: An Alternate
Approach to Accelerating Medical Countermeasures

A “Treat the Symptoms”
Approach
LTC Barbara Cloutier
Defense Threat Reduction Agency
Joint Science and Technology OfficeRepurposing and Redirecting: An Alternate
Approach to Accelerating Medical Countermeasures

Impacts of Chemical Biological
Defense Program Approach toResearch, Development, andAcquisition of Medical
Countermeasures and Test Products
Dr. Tony Cardile
Joint Project Manager for CBRN Medical

Repurposing and Redirecting: An Alternate
Approach to Accelerating Medical Countermeasures

Discovery of Medical
Countermeasures Against
Novel Entities (DOMANE)
Dr. Dave Hone
Defense Threat Reduction Agency
Joint Science and Technology Office

UNCLASSIFIED

Discovery of Medical Countermeasures Against Newand Emerging threats (DOMANE)MCM Discovery Cycle
Adaptive
Clinical
Trials

JPL-EB GUIDE
Scale up datasets anddata curation

MCMRegimen

MEDFIND/
MED3D
Candidate
MCMs

MCM Planning Cycle

AMDST
MedicalPlanners

DATA

Joint Force

Target ID

TARGFIND

Pathogenesis &Toxicity
Forecasting

PATMOS

New &Emerging
Threats

JPM Medical RAIDR
Data harvest andpreemptive solution sets
UNCLASSIFIEDAMDST: Agile MCM Decision Support Tool

Leading S&T for Chem-Bio Defense

Repurposing and Redirecting: An Alternate
Approach to Accelerating Medical Countermeasures

Rapid Acquisition andInvestigation of Drugs for
Repurposing (RAIDR)COL Ryan Eckmeier
Joint Project Manager for CBRN Medical

REPURPOSING MEDICAL COUNTERMEASURES FOR CBRN DEFENSE• Leverages investments and knowledge gained in conventional medical countermeasuredevelopment• Fast and affordable way to deliver interim capabilities for known, potential, andunknown emerging threatsoCollaborative with inter/intra-agency partners, academia, and industry

oProven during COVID-19 responseooLeverages established safety andmanufacturingBridging the GapBridges the gap until complete
capabilities are in place25Repurposing and Redirecting: An Alternate
Approach to Accelerating Medical Countermeasures

Question and Answer
SessionHow to Work with DoD

How to Work with DoD

Recent Success Using Nontraditional Approaches andMethods for Working with DoD
Ms. Nicole Kilgore
Deputy Joint Program Executive Officer

How to Work with DoD

Other Transaction Authority –Medical CBRN Defense (MCDC)
Consortium
Mr. Lee Hess
JPEO-CBRND

30

KEY OTA FEATURES• OTAs have the following key features that enhance both the contractor and Government experience:o Open Communications: Government requiring office and Consortium Members are free to discuss anyproject attributes including cost, schedule and performance, new ideas/approaches, forecasts, etc.
• No need to formalize discussions• No need to distribute discussion information• Exceptions:• Cannot discuss proprietary information of another contractor• Discussions are closed during evaluation periodso “Commercial Like” financing and payment terms
o Follow-on Production (successful completion or unanticipated favorable results)o Negotiable IP and data rights
o Flexible - (T&C, agreement types, evaluation process, success metrics, deliverables)o Streamlined – (EWP w/ROM vice formal proposal)
o Basketo FAR DOES NOT APPLY

Unclassified31

MCDC OTA
Traditional, 11%

Non-Traditional,
89%

Non-Traditional/Traditional Distribution

307 Members
Academic, 9%•••••••••FY 16, 17 RPP (5 Projects), 9 Awards, 0 Basket; FY 16-17 Basket Pulls - 1
FY 18 RPP (11 Projects), 23 Awards, 14 Basket; FY 18 Basket Pulls - 10
FY 19 RPP (12 Projects), 16 Awards, 17 Basket, FY 19 Basket Pull - 4
FY 20 RPP (17 projects), 23 Awards, 21 Basket, FY 20 Basket Pull - 1
FY 21 RPP (6 Projects), 7 Awards, 7 Basket, FY 21 Basket Pull – 0
FY 22 RPP (10 Projects), 1 Awards, 8 Basket; FY 22 Basket Pulls - 0

Awarded Member Ceiling - $8,728,577,171 Total Ceiling Cost (w/CMF Fee) $8,778,119,266
Funded To Date - $7,907,917,272
Disbursed (Inc CMF C&F) $5,356,349,640
Paid to Performer - $5,150,749,013
Note: All totals include OWS awards
Large, 13%

Small,
68%

Total Awarded Projects: 79
Active Funded Projects: 69

Not-ForProfit, 8%

Unclassified32

HOW TO JOIN THE MCDC OR CWMD CONSORTIUM• Visit: www.medcbrn.org or www.cwmdconsortium.org• Complete and sign the Membership Applicationo Review and sign the Articles of Collaborationo Provide DD2345 Certification Number
 Military Critical Technical Data Agreement (access to unclassified technical data) Instructions available at www.medcbrn.org or www.cwmdconsortium.org
o If operating under Foreign Ownership, Control or Influence (FOCI) DSS-approved mitigation plan OR signed Export Compliance Acknowledgement Formo Membership limited to US firms/entities or US-based affiliates of foreign firms/entities• Send to MCDC@ati.org or CWMD@ati.org• For all inquiries contact Mike Stebbinso mike.stebbins@ati.org
o 843-760-4094

Unclassified33

CONTACTMr. Keith Batchelor

OTA Program Manager
240-586-15253
roger.k.batchelor2.civ@army.mil

Mr. Lee HessOTA Program Manager
240-344-0462
lee.a.hess.civ@army.mil
Public Affairs Office: 410-436-9000
Traditional Contracting: Alan Burket | 443-655-8608
Website: www.jpeocbrnd.osd.mil
Social Media: @JPEOCBRND

BACKUPSGETTING TO AGILE
DIVERSE ACQUISITION TOOLS AND THE PEOPLE WHO KNOW HOW TO USE THEMProgram and SETA support MATOC

Awards outside of MATOCs and OTAs
• Primarily awards of legacy
components or are sole source• Centralized management and support• Standardized processes and procedures

Medical and CWMD OTAs:• Inspires technical innovationand expedited awards• Expands industrial baseto “Non-Traditional” Defense contractors• Encourages partnerships amongst both
Industry and Government entities

Enterprise-wide logistics
and sustainment MATOC

Systems, equipment,and capabilities MATOC

Key tools are knowledge and transparency:
Multiple venues for Government and Industry
interaction. Multiple training opportunities for JPEO
staff, other partners and industry. One goal, equipping
UNCLASSIFIED
people to know how to use the right tool for the job.
Unclassified• Pre-MDD through development,
production, procurement, fielding
and initial sustainment

2018_7_2_CommandBrief
36

MCDC OTA PARTNERSHIP STRUCTURE
MCDC OTA PROGRAM
MANAGEMENT OFFICEPROJECTSPONSORS(CONTRACT MANAGEMENT OFFICE (CMO))AGREEMENTS
OFFICER

Army Contracting
Command –New Jersey

CONSORTIUM
MANAGEMENT
FIRM

Unclassified

PROJECTHOLDERS37

CWMD OTA PARTNERSHIP STRUCTURE
PROJECTSPONSORSCWMD OTA PROGRAM
MANAGEMENT OFFICE(CONTRACT MANAGEMENT OFFICE (CMO))AGREEMENTS
OFFICER

Army Contracting
Command – New Jersey

CONSORTIUM
MANAGEMENT
FIRM

PROJECTHOLDERS
Unclassified38

OBJECTIVE AREAS• CBRNE counter-proliferation, nonproliferation, and defense equipment• Installation and force protection• Command, control, communications, computers, intelligence, surveillance, and reconnaissance (C4ISR)
systems for WMD detection, localization, identification, and tracking and CBRNE response operations• Technologies that support the find, fix, finish, exploit, analyze, and disseminate (F3EAD) process• Preparing for and combatting improvised threats and the improvised explosive device network• WMD precursor, agent, and device defeat or neutralization• Ensuring nuclear deterrence• Manned and unmanned platforms capable of supporting CWMD operations• Technologies that enhance the effectiveness of forces that are tasked to conduct CWMD operations• Other operations related to the CWMD mission

Unclassified39

CWMD OTA
Traditional, 13%

•••
•
•

Non-Traditional,
87%

FY 18 RPP (34 Projects), 22 Awards, 0 Basket; FY 18 Basket Pulls - 1 (Expired)
FY 19 RPP (37 Projects), 51 Awards, 16 Basket, FY 19 Basket Pull - 5
FY 20 RPP (42 projects), 29 Awards, 80 Basket, FY 20 Basket Pull - 2
FY 21 RPP (19 Projects), 52 Awards, 40 Basket, FY 21 Basket Pull - 6
FY 22 RPP (06 Projects), 12 Awards, 03 Basket, FY22 Basket Pull - 5

Non-Traditional/Traditional Distribution

398 Members
Academic, 5%•••Awarded Member Ceiling - $1,066,645,397 Total Ceiling Cost (w/CMF Fee) $1,077,038,549
Funded To Date - $838,297,945
Disbursed (Inc CMF C&F) $846,364,106
Paid to Performer - $726,608,192
Large, 16%

Small,75%

Bi-Weekly CWMD OTA Status Update

Not-ForProfit, 4%

Total Awarded Projects 166
Active Funded Projects 101

Unclassified40

KEY PROGRAM ROLES & RESPONSIBILITIESYOU ARE NOT ALONE!

• Program Management Office (JPEO-CBRND)
Execute program strategy and marketingo Manage operations• Consortium Management Firm (ATI)Manage consortiumo Maintain on-line process for bid managemento Conduct pricing certificationso Complete compliance checkso Award sub-agreementso Monitor post-award performance against technical milestones
o Manage payment processoo

 Monitor Cost, Schedule, and Technical PerformanceoProvide acquisition support and expertise Contractual (1101/1102 series) Technical (0800 and 1300 series)oMaximize customer service and support
 Training• Agreements Officer (ACC-NJ)

Review and approve requirementso Review and approve evaluations of white
papers/proposals
o Prepare Determination and Findings -- award
approvalo Facilitation of legal and SCO reviewso Perform post-award administration• Agreements Officer’s Representative• Write requirements with program team
• Conduct evaluations• Draft selection memoranda• Monitor cost, schedule, and technical performance• Approve deliverables• Approve payments, etc.
• Communicate any changes
to PMO/AO
2018_7_2_CommandBrief

UNCLASSIFIED
Unclassified41

How to Work with DoD

JPEO-CBRND EnterpriseTechnology Tool (JETT)
Overview
Mr. Josh Israel
JPEO-CBRND

JPEO ENTERPRISE TECHNOLOGY TOOL (JETT)COMING SOON: A new conduit to connect directly with the JPEO!
» JETT is a web-based software application thatfacilitates industry engagement» Connects companies to the “right” point(s) of contact
based on answers to a short questionnaire» Companies can also upload documents andadditional information» Submissions will go directly to point(s) of contact forreview and follow-up
https://www.jpeocbrnd.osd.mil/Work-With-Us

43

Closing Comments

CALL FOR PAPERS

Empowering
the Warfighter:
Resilience
ThroughInnovation

H

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