Spectral Sensors by Carl Zeiss

Z o d ia C
Z e is sO p t ic a l D is s o lu t io n I n -s it u A n a ly s is

INTR ODUC TION
T he us e of fibre optic probes in dis s olution monitoringin analytical development and new product formulation
tes ting in pharmaceutical analys is is a relatively newtechnique and offers pos itive benefits to the indus try.
Zeis s has been at the forefront of this development fora number of years us ing its s tate of the art diode array
detection s ys tem which is des igned and optimis ed for
fibre optics – T he MC S 500 s eries .
In-s itu analys is us ing fibre optic (F /O) probes avoids
the problems as s ociated with an extractive s ys tems uch blockage of tubing and filters . Als o ads orption
and precipitation on filters and Teflon tubes can leadlower concentrations . T he time cons uming proces s ofcalibration of flow and pumps is totally avoided by theus e of F /O probes . T here is no dilution error as nomedia is removed and s horter time points are pos s ible
for accurate profiling when compared to manual andmos t automated methods .
Zeiss together with Zymark Ltd, E ngland developed afully automated robotic s ys tem utilis ing a s ingle F /Oprobe linked to the Zeis s MC S Diode Array
S pectrometer in 1996. S everal systems have been
ins talled s ince then and have been s ucces s ful inoperation.
A new development from Zeis s is the ZodiaC . T his
us es multiple F /O probes for multi-channel analys iswith the proven MC S s pectrometer coupled to an 8channel multiplexer. Initially targeted for s us tained
releas e products with dis solution profiles of 24-48
hours , the s ys tem can als o be us ed for fas t releas eproducts . T he s ys tem can meas ure time points of aminimum of 1 minute due to the us e of a fas t andprecis e multiplexer with a proven reliability record in
the telecommunications indus try. Dicon and Zeis shave optimised it for UV -V IS operation.

〒164‑0011
東京都中野区中央4‑4‑5第一小林ビル
Tel: 03‑5328‑2858 Fax: 03‑5328‑2859

and C ontr ol

Spectral Sensors by Carl Zeiss

Real time display of profiles and spectra

THE Z-DIS-MUX SOFTWARE• LabView programme under NT linked to client network fordata storage and printout of reports• Security access and password protected• Validation screen for testing and checking statusof Vankel, Dicon and MCS hardware• Automatic and manual operation• All measurements and report generation are automatic
freeing operator for other tasks• Automatic Interchannel Calibration
with bubble detection
Paddle shaft,F/O probe and Temperature sensor

OPERATION• Vankel bath prepared for paddles or baskets• Vessels manually filled with media• All probes lowered for Interchannel Calibration• System suitability check using positions 4 and 8• Standard in vessel 4 and with blank solution in 8
• System ready to run• Total time for above is about 30min
SPECIFICATIONS• MCS 551 UV, range 200 – 620nm, resolution 0.8nm/pixel

Patented Diode Array - MCS sensor• Photometric accuracy for all channels - +/- 0.01Au• Wavelength accuracy for all channels - <0.3nm• Stray light at 240nm <0.1%T• Noise - <0.0005 Au RMS• Drift - 0.0004 Au/hr• Channel switching time - < 3 seconds• Typical measuring time per channel, based on 10 coadds ofspectra < 3 seconds

Carl Zeiss
Spektralsensorik

D-07740 Jena
Telefon:(03641)64 2838
Telefax:(03641)64 2485
E-Mail:info.spektralsensorik@zeiss.de
Internet:
http:// www.zeiss.de