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Vol.25, October 2019

“Okayama University supports the Sustainable Development Goals”
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Vol.25, October 2019

Contents
FeatureTwo symposia commemorating the 70th anniversary of Okayama University to further contributeto the SDGs

News・ Whole Institution’s Approach of SDG efforts presented at the UN headquarters: University
officials led by President Makino participate in the High-Level Political Forum in July 2019・ Welcome reception held by Okayama University and the U.S. Department of State for CLS

American students
・ Promote the SDGs across generations! The SDGs Youth Project launched・ Okayama University accredited to implement the “Support Program on Collaborative
Innovation Networks for Medical Device”
・ Okayama University Weight Training Club won the national championship!

Research Highlights
・ Identification of the proteins governing the formation of “magnetic teeth” in chiton
Chiton deposit magnetite (Fe3O4) on their mineralized radular teeth.
・ Observation of instabilities in metallic states for metal-to-insulator switch oxides
・ Challenging the theoretical assessment of a hypothesis on protein folding stability that has been
believed for 60 years

TopicsRadio Message from International Students (World Heartful Message)

Further information
About Okayama University

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Vol.25, October 2019

FeatureTwo symposia commemorating the 70th anniversary of Okayama University to further
contribute to the SDGs

Okayama University was established in 1949 and is celebrating its 70th anniversary in 2019. Authorized
by the United Nations as the first institute in Asia to establish a UNESCO Chair in 2007, the university
has launched initiatives to promote Education for Sustainable Development (ESD). In 1994 the university
it became the first national university in Japan to establish an environment-focused faculty: The Facultyof Environmental Science and Technology. This is an example of Okayama University’s continued efforts
on promoting the SDGs with the involvement of members of local community. On 9th July the university
organized two SDG-themed symposia in commemoration of its 70th anniversary.
The theme of the first symposium was “Water and Lifein Okayama”. This theme was chosen because one year
has passed since torrential rain in July 2018 caused
tremendous damage in western Japan.
Addressing an audience of local residents young
researchers from Okayama University described theirlatest results on lifestyles and culture related towater—the source of life. Associate Professor Keisuke
Yoshida from the Graduate School of Environmental and Life Science made a presentation about
technology to make detailed measurements of wide-area landform from aircraft, for accurately predicting
the flow of water during heavy rainfall. Other talks were on the development of Nishikawa Ryokudo Parkin the center of Okayama, and on research focused on the DNA of marine creatures in the Seto Inland Sea,
with the goal of conserving the sea environment.
The

next

symposiumwas,“Towards

Greater

Okayama as the Center for the U.S. and Japan Youth
Development to Advance the SDGs”, commemorating
Okayama University’s selection this year as the firstnational university in Japan to accept students under
the Critical Language Scholarship (CLS) Program*sponsored by the U.S. Department of State. A panel
discussion took place with the participation of
President Hirofumi Makino of Okayama University,
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Dr. David Patton, President and CEO of American Councils, and students participating in the CLS
Program. The panelists exchanged opinions about the advantages of human resource development being
conducted in Okayama, a place known for close ties amongst local communities, and how they can promote
this initiative more effectively.
As a leader for SDG promotion in Japanese academia, Okayama University will continue its efforts tocontribute to the SDGs in collaboration with local communities and partners worldwide to create newsocial values and advance global partnerships for the SDGs and ESD. Let’s change the world with theSDGs and ESD with our partners worldwide!
* A program for university/graduate school students from top-class American universities to learn
Japanese language and culture in Japan.

Further information
Okayama University (Japanese page)
http://www.okayama-u.ac.jp/tp/news/news_id8628.html
Okayama University (Japanese page)
http://www.okayama-u.ac.jp/tp/news/news_id8635.html
UNESCO Chair at OKAYAMA UNIVERSITY
https://edu.okayama-u.ac.jp/unesco_chair/public_html/en/index.html
Welcome reception held by Okayama University andthe U.S. Department of State for CLS American students
https://www.okayama-u.ac.jp/eng/news/index_id8639.html
United Nations
https://sustainabledevelopment.un.org/hlpf/2019

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News

Whole Institution’s Approach of SDG efforts presented at the UN headquarters:
University officials led by President Makino participate in the High-Level Political
Forum in July 2019

On July 15, President Hirofumi Makino made a presentation
about Okayama University’s initiatives at a side-event of theHigh-level

Political

Forum(HLPF)

for

Sustainable

Development for 2030” held at the UN headquarters. It wasorganized by UNESCO and co-organized by the governmentsof Japan, Germany and Kenya.
To mark the beginning of the event, Ms. Stefania Giannini,
Assistant Director-General for Education at UNESCO,
explained the event’s purpose: to inspire people’s interest in

Presenter: President Hirofumi Makino, panelist：
From the left to right: Ms. Stefania Giannini,
Assistant Director-General for Education at
UNESCO, Leich UNESCO ESD Manager

the contribution of ESD to the achievement of the SDGs, and to discuss frameworks plans for ESD
towards 2030. Then, Mr. Fumiyasu Hirashita, Deputy Director-General for International Affairs at
MEXT and Senior Deputy Secretary-General of Japanese National Commission for UNESCO, delivered acongratulatory message to the event, referring to the important role the co-organizers (governments ofJapan, Germany and Kenya) play in the promotion of ESD aimed at the achievement of the SDGs.
Following

this,

President

Makino

made

the

only

presentation at the event to introduce the university’s
initiatives. He stated that the university has led ESD on a
global scale since 2005 in cooperation with Okayama City,
that university-wide and region-wide “whole institution’s
approach” toward the SDG achievement has been
implemented under the Makino Vision, that the university
received the first Japan SDGs Award from the governmentof Japan for its achievement through the approach, and thatthe university led the creation of

the “Asia-Pacific

Frameworks for Teacher Education on ESD” as a specific

From the right to left Mr. Fumiyasu Hirashita, Deputy
Director-General for International Affairs at MEXT and
Senior Deputy Secretary-General of Japanese National
Commission, President Hirofumi Makino The forth fromthe right is Haugg Director General for Vocational
Training and Lifelong Learning, German Federal Ministryof Education and Research The fifth from the right isProfessor Kazuhiro Yoshida（Hiroshima University）

effort to achieve the SDGs. He also announced that theuniversity will host an international conference on the global framework for teacher education on ESD in
November 2019.

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A panel discussion chaired by Ms. Giannini also took place,with the participation of Professor Kazuhiro Yoshida from
Hiroshima

University(Co-chair,

SDG-Education

2030

Steering Committee), Ms. Kornelia Haugg (Director Generalfor Vocational Training and Lifelong Learning, German
Federal Ministry of Education and Research) and Ms. Kerstin
Forsberg from Planeta Océano in Peru. They commented that
the SDGs are a significant agenda that cannot be achieved
without education, that ESD is the key for the achievement

From the left to right: The Vice President Atsufumi
Yokoi, The Ambassador Kouro, Besyo President
Hirofumi Makinoof the SDGs, that links and networks among diverse sectors
are essential, and that Okayama University has taken the lead in the movement through the “whole
institution’s approach” with its capacity and reliability that meet the global standard. The panelists
seemed to have been particularly impressed with the presentation about the “whole institution’s approach”
by President Makino, and the topic determined the direction of the discussion.
Approximately 20 persons from the government, industry andacademia constituting the Japanese governmental delegation to
the UN HLPF were present at the dinner party held on thatevening,

hostedbyAmbassador

Extraordinary

andPlenipotentiary, Permanent Representative of Japan to theUnited Nations. President Makino and Vice President Atsufumi
Yokoi also attended, and exchanged information widely withother participants on Japan’s present situation and future course
From the left to right: The Councilor Mr. Kato,
President Hirofumi Makino,The Ambassador
Tomoya Hoshino, The Vice President Atsufumi
Yokoi

of action regarding the SDGs.

Further information
United Nations
https://sustainabledevelopment.un.org/hlpf/2019

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Vol.25, October 2019

News

Welcome reception held by Okayama University and the U.S. Department of State for
CLS American students

Okayama University is the first national university selected tohost American students who have been accepted to the Critical
Language Scholarship (CLS) Program. The competitive
scholarships funded by the U.S. Department of State wereawarded to 26 outstanding undergraduate and graduate
students who have shown outstanding academic ability andleadership potential at their colleges and universities. The
program runs for eight weeks from June 14 to August 10,

President Makino making his ceremonial speechoffering highly intensive course work in Japanese language andculture at Okayama University. A welcome reception was
kicked off on June 17 at the Okayama University International
House.
In his welcome speech, Okayama University President
MAKINO Hirofumi said that, while studying abroad, headopted a positive and optimistic attitude and learned toappreciate his own Japanese culture from a different

Greetings from CLS student representative Mr.
David Anderson

perspective. He encouraged students, regardless of how they feel about the upcoming program and life in
Okayama, excited or nervous, to take a new step forward and participate actively in the program. CLS
students briefly introduced themselves in Japanese by telling where they were from and sharing any
Japanese words and phrases they liked most. Then, Mr. David Anderson delivered an engaging speech on
behalf of the CLS cohort, saying that they would spend eight productive weeks in Okayama so they could
broaden their perspectives and knowledge through cross-cultural exchange and learn to see the world fromdiverse viewpoints.

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Commemorative photo

Further information
American Councils for International Education
https://www.americancouncils.org/programs/critical-language-scholarship-program

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News

Promote the SDGs across generations! The SDGs Youth Project launched

Under the Makino Vision, Okayama University is making
university-wide efforts to promote the Sustainable
Development Goals (SDGs) suggested by the United
Nations as one of its focused initiatives. In handling theSDGs, we need to achieve common goals with diverse
stakeholders, and as such, it is important to foster
relationships across generations. Thus Okayama University
is working on the SDGs with the younger generations,reflecting their various ideas and opinions on the

Mr. Morishita giving a lecture

university’s SDG activities. Recently, the nationwide project“SDGs Youth Project” designed by Mr. KOMURA Shunpei (Special Advisor to the President) to connect
high school students with the SDGs, was launched with the involvement of the university’s Tokyo Office.
The kickoff event was held in the Tokyo Office (Minato-ku, Tokyo) on April 17.
Thirty-four high school students from across the country
participated in the event, this time focusing on Goal 16:
Peace, Justice and Strong Institutions. Mr. MORISHITA
Yuichiro, a social activist, spoke as a guest. Being a former
professional basketball player in the United States, he now
travels around the world and is engaged in various activities
to realize a peaceful society and promote regional
revitalization. Referring to actual cases, he talked in front ofhigh school students about what he felt and learned from his
experiences. Professor KANO Mitsunobu, Vice Executive

Participants who perform graphic facilitation

Director in charge of promoting Okayama University’s efforts to help achieve SDGs and other officials
participated in the cross-generational discussion with high school students on what a peaceful society
should be like, based on Mr. Morishita’s speech.

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Participants listening to the story of Vice Executive

Vol.25, October 2019

Commemorative photo with participants

Further information
OKAYAMA UNIVERSITY × SDGs
https://sdgs.okayama-u.ac.jp/en/

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News

Okayama University accredited to implement the “Support Program on
Collaborative Innovation Networks for Medical Device”

Okayama University was selected as an institution to
implement the “2019 Support Program on Collaborative
Innovation Networks for Medical Device” of the Japan
Agency for Medical Research and Development (AMED).
The project, based on the results achieved through the“Project to Build Foundations to Support and Incentivize
Development of Medical Devices Made in Japan”
implemented for five years from 2014, pursues to increase

The picture of the operation

the number of companies’ hubs to foster human resources to be engaged in the development of medical
devices, and create attractive medical hubs featuring characteristics of each medical institution andleading to the promotion of the medical device industry. Fourteen institutions including Okayama
University were selected.
Okayama University has set the goal of developing a center for medical device development focused on
open innovation and the promotion of commercialization. Okayama University Hospital and its affiliatedfive hospitals constitute a “mega-hospital.” Making use of the advantage of its scale, the university will
establish a system to collect wide-ranging medical needs, covering the fields of general medicine, nursing,nursing care, rehabilitation, dental medicine, and home healthcare. In addition, through close cooperation
among the university, governments and the business world, the university will achieve seamless
implementation of the creation of valuable business models, business matching and commercialization.
Making use of this opportunity, the university will continue its efforts to foster human resources for
medical device development and further contribute to the development of medicine, based on the results
achieved during the past five years.
Further information
OKAYAMA UNIVERSITY HOSPITAL
https://www.okayama-u.ac.jp/user/hospital/en/index.html

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Vol.25, October 2019

News

Okayama University Weight Training Club won the national championship!

Okayama University Weight Training Club won the firstplace at the 46th all-Japan intercollegiate powerlifting
championship for MEXT Minister’s cup held on June 30
at Hannan University in Osaka. The team members paida call on President Makino on July 9 and reported theresults.
Commemorative photo

Powerlifting is competed by the total weight of the best of
three attempts at the three lifts: squat, bench press and deadlift. At this competition, the contestants
competed in individual match for each weight class, and the ranking of the participating 16 universities isdetermined by the grades of individual rankings.
In the individual match, four students from Okayama
University ranked first: Ms. Momoka Kumahara for women’s
52 kg class (4th year, Faculty of Law), Ms. Kana Okada for
women’s 63 kg class (2nd year, Discovery Program for Global
Learners), Mr. Takuro Teraoka for men’s 53 kg class (2nd year,
Faculty of Economics), and Mr. Koichiro Arioka for men’s105+ kg class (4th year, Faculty of Science). Among them, Ms.
Okada achieved national university records for all of the three
lifts as well as for the total score! Many students from Okayama

Picture of the report

University ranked high in individual matches, and the university as a team won the championship for the
first time in three years!
When they were asked by President Makino how they felt about winning the championship, the captain
Mr. Yuki Yamato (4th year, Faculty of Environmental Science and Technology) answered, “We couldn’t
achieve satisfactory results last year, but I was glad to get our revenge.” Last year, the team finished fourth
prize, missing the podium. The frustration had led to this year’s excellent results.
In its history of 30 years, the club has won the national championship 13 times so far. When they wereasked “What was the secret of the strength?”, the captain humbly answered, “It’s all thanks to theguidance of our seniors.” Traditionally, alumni of the Weight Training Club serve as directors and coaches
to foster the next generation. Thanks to this system, club members can receive their seniors’ shrewd advice
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and appropriate assistance, and improve their technical skills without suffering from major injuries. Thisis the secret of their strength.

The Group Picture

Picture of the competition

Further information
Okayama University Weight Training Club (Japanese page)
http://www.ouwtc.com/

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Research Highlights

Identification of the proteins governing the formation of “magnetic teeth” in chiton
Chiton deposit magnetite (Fe3O4) on their mineralized radular teeth.
In order to form the magnetite under physiological conditions, it was suggested that chitons might use
biomolecules, such as proteins, to control oxidation / reduction of iron oxides. However, due to the lack ofdetailed molecular biological analysis of chitons, mechanisms of magnetite teeth formation are not clear.
Michiko Nemoto, Graduate School of Environmental and life Science Okayama University and David
Kisailus, Department of Chemical and Environmental Engineering, University of California, Riverside
report the first comprehensive gene inventory of gumboot chiton, Cryptochiton stelleri, providing abroad overview of magnetite teeth mineralization. Furthermore, their work identified several proteinsthat may be involved in magnetite formation.
To reveal the proteins involved in magnetite mineralization, RNA (transcription products) wereextracted from radular tissue and sequenced using a next generation sequencing platform. As a result, acomprehensive gene inventory of radular tissue that consists of more than 100,000 genes was
successfully developed. The gene inventory was also used for a proteomic analysis of radular teeth
proteins.
This is the first report describing a comprehensive analysis of genes and proteins expressed in chiton thathas magnetite teeth. Furthermore, this study successfully identified several proteins associated withmagnetite teeth that may be involved in magnetite formation in chiton.
The results of this study pave the way for developing a low temperature, environmentally benign
biological process to produce magnetite for a wide range of applications including magnetic recording,secondary battery, and MRI contrast agents.

Figure caption: Cryptochiton stelleri (left) and its magnetic teeth (right).

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Reference:・Authors: Michiko Nemoto, Dongni Ren, Steven Herrera, Songqin Pan, Takashi Tamura, Kenji
Inagaki and David Kisailus

・

Title of original paper: Integrated transcriptomic and proteomic analyses of a molecularmechanism of radular teeth biomineralization in Cryptochiton stelleri

・
・
・
・
・
・

Journal, volume, pages and year: Scientific Reports 9:856 (2019).
Digital Object Identifier (DOI): 10.1038/s41598-018-37839-2
Journal website: https://www.nature.com/articles/s41598-018-37839-2
Affiliations: Graduate School of Environmental and life Science, Okayama University
Department website: http://www.gels.okayama-u.ac.jp/index_e.html
Okayama University Scientific Achievement Repository:
http://ousar.lib.okayama-u.ac.jp/57012

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Research Highlights

Observation of instabilities in metallic states for metal-to-insulator switch oxides

Vanadium dioxide (VO2) shows a metal-to-insulator (MI)switch near room temperature (Fig. 1). Since switching
phenomena near room temperature are rare, VO2 has
attracted attention for its switching mechanism, namely, theinstability in the metallic state. Theoretical work onelectronic structures of VO2 40 years ago suggested that the
instability is responsible for electron-phonon interaction [1].
Since then, much interest has been directed to experimental
studies of electronic structures of VO2 using angle-resolved
photoemission electron spectroscopy (ARPES).
However, ARPES measurements of VO2 single crystals are

Fig. 1. Temperature dependence of the resistivity
for a VO2 epitaxial thin film on a TiO2(001) substrate.

difficult to perform because of the difficulty in obtaining a chemically stable cleavage plane in VO2 single
crystals with three-dimensional crystal structure.
Now, Yuji Muraoka and colleagues at Okayama University, High Energy Accelerator Research
Organization, and University of Tokyo have determined the electronic structures of the metallic phase of
VO2 through studies of VO2 epitaxial thin films grown on TiO2(001) substrates, using synchrotron
radiation ARPES.
The electronic structures possessed a flat portion thatis evidence for the presence of electron-phonon
interaction predicted by theoretical work (Fig. 2).
The results obtained by Muraoka and colleagues
strongly indicate the importance of electron-phonon
interaction for the origin of the instability in themetallic state of VO2, and support the validity oftheoretical work.
This research advances the understanding of theFig.2. Electronic structure of a metallic phase of VO2
epitaxial thin film on a TiO2(001) substrate. A flat portionis indicated with a black line.

mechanism for the MI switch in VO2, and provides
fundamental knowledge for controlling the switching temperature for potential applications.
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Vol.25, October 2019[1] M. Gupta, A. J. Freeman, and D. E. Ellis, Phys. Rev. B 16, 3338 (1977).

Reference:・Authors: Yuji Muraoka1, Hiroki Nagao2, Yuichiro Yao2, Takanori Wakita1, Kensei Terashima1,
Takayoshi Yokoya1, Hiroshi Kumigashira3,*, and Masaharu Oshima4.

・

Title of original paper: Fermi surface topology in a metallic phase of VO2 thin films grown on
TiO2(001) substrates.

・
・
・
・

Journal, volume, pages and year: Scientific Reports 8, 17906 (2018).
Digital Object Identifier (DOI): 10.1038/s41598-018-36281-8
Journal website: https://www.nature.com/articles/s41598-018-36281-8
Affiliations: 1Research Institute for Interdisciplinary Science, Okayama University, 2Graduate
School of Natural Science and Technology, Okayama University, 3High Energy Accelerator
Research Organization (KEK), Photon Factory, 4The Institute for Solid State Physics, The Universityof Tokyo.
*Present address: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

・・

Department website: http://www.science.okayama-u.ac.jp/~surface/index.html
Okayama University Scientific Achievement Repository:
http://ousar.lib.okayama-u.ac.jp/57013

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Research Highlights

Challenging the theoretical assessment of a hypothesis on protein folding stability
that has been believed for 60 years

Understanding the dominant factor behind thermodynamic
stability of proteins is still a challenging issue inbiochemistry,

biophysics,

andmolecular

biology.

Kauzmann’s hydrophobic interaction hypothesis, which
considers solvation effects mediated by water as thedominant factor in thermodynamic stability of proteins, hasbeen widely accepted for about sixty years and attracted
many scientists. However, the hypothesis has not beenverified or disproved because it is difficult, both theoreticallyand experimentally, to quantify the solvent effects on

Fig. 1 Thermodynamic cycle on energetics of protein folding.

protein stability.
The theoretical physical chemistry group at the Research Institute for Interdisciplinary Science, Okayama
University (Tomonari Sumi and Kenichiro Koga) developed a computational method to quantify
energetics of protein folding stability and applied it to a small design protein chignolin. On the basis ofresults obtained for chignolin, they derived an obvious conclusion that was qualitatively different fromthe hypothesis: the driving force of the protein folding is attributed to the intramolecular interactions of
the protein and the solvent effects rather stabilize unfolded states. These results provide new insights forstrategies to design artificial proteins and developments of new biopharmaceuticals.
Reference:

・
・
・
・
・
・
・
・

Authors: Tomonari Sumi and Kenichiro Koga.
Title of original paper: Theoretical analysis on thermodynamic stability of chignolin.
Journal, volume, pages and year: Scientific Reports 9, 5186 (2019).
Digital Object Identifier (DOI): 10.1038/s41598-019-41518-1
Journal website: https://www.nature.com/articles/s41598-019-41518-1
Affiliations: Research Institute for Interdisciplinary Science, Okayama University.
Department website: http://www.riis.okayama-u.ac.jp/en/
Okayama University Scientific Achievement Repository:
http://ousar.lib.okayama-u.ac.jp/57014

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TopicsRadio Message from International Students (World Heartful Message)
Okayama University was broadcasted an internet radio
program in which international students who have cometo study at Okayama University from countries all over
the world talked on topics such as their life asinternational students, what it is like to live in Okayama
City, and their research themes. The broadcasts were
produced in English or the native languages of thestudents.
Ms. IRSAN Raina Mentari of Discovery Program for
Global Learners from Republic of Indonesia talked about
her research and plans for the future.

Ms. IRSAN Raina Mentari (right)

Further information
https://www.youtube.com/watch?v=AOTCFQv5bOw
Radio Message from International Students
https://www.youtube.com/playlist?list=PLJikPQTwoCj4ggrOUY2cs_AJZIeWdG4t8

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◆Further information
Okayama University
1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
Public Relations
E-mail: www-adm@adm.okayama-u.ac.jp
Website: https://www.okayama-u.ac.jp/index_e.html
Okayama University e-Bulletin
https://www.okayama-u.ac.jp/user/kouhou/ebulletin/
Okayama University Medical Research Updates (OU-MRU)
https://www.okayama-u.ac.jp/eng/research/ou-mru.html
About Okayama University (YouTube 1)
https://www.youtube.com/watch?v=iDL1coqPRYIOkayama University Image Movie (YouTube 2)
https://www.youtube.com/watch?v=KU3hOIXS5kk◆About Okayama University
Okayama University is one of the largest comprehensive universities inJapan with roots going back to the Medical Training Place sponsored by the
Lord of Okayama and established in 1870. Now with 1,300 faculty and13,000 students, the University offers courses in specialties ranging frommedicine and pharmacy to humanities and physical sciences.
Okayama University is located in the heart of Japan approximately 3 hours
west of Tokyo by Shinkansen.
Hirofumi Makino, M.D., Ph.D.
President, Okayama University“Okayama University supports the Sustainable Development Goals”
1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530 Japan© Okayama University
20