AFPS2017 –Asian Federation for Pharmaceutical Sciences 2017
November 21st-23rd, 2017
Wanda Realm Xiamen North Bay , Xiamen, China

MORIMOTO Pharma.Co.,LtdPresident

SHUJI MORIMOTO
Copyright MORIMOTO Pharma LIMITED.

MORIMOTO Pharma.Co.,Ltd
設 立 Founded： ２００５、May

盛本修司（-2002 TAKEDA PHAMACEUTICAL
元武田薬品 製剤研究）
Lansoprazple OD, Leupron depo)

代表者 CEO ： SHUJI MORIMOTO

資本金 capital ： 6０,000,000 JYEN

事業内容 Business ： R&D for New Dosage Form

Jelly Products
Licence GMP & China Consulting, Partnaring, etc
Nursing Care Busibess

所在地 Address： Head Office, R&D, Plant
Osaka Japan
ホームページ ： http://www.morimoto-iyaku.jp

Copyright MORIMOTO Pharma LIMITED.

～ Jelly product lineup ～1982年

2002年

2005年

2015年

TAKEDA pharmaceutical

MORIMOTO-Pharma

专利:約70件

約30件

JellyJelly

果皮包装（易剥离）风湿症用進化
Copyright MORIMOTO Pharma LIMITED.

TAKEDA pharmaceutical --TIANJIN Main productｓ①Lansoprazole ② Lansoprazole OD Tablet

Orally disintegrating tablets

2001 Lansoprazole OD Tablet is launched（contain lansoprazole granule）
Enteric coating: 35μ m
Main drug layer:

coating

75μ m

Nuclear particle 50μｍ

Enteric coating: 50μ m
10 μm
Intermediate layer:：Main drug layer:： 30 μm
Nuclear particle 170μ m

Current tablet（ 30mg/ 370mg)
Diameter： 1070μ m

Granule( 30mg/ 200mg)
Diameter： 350μ m

TAKEDA pharmaceutical --TIANJIN Main productｓ③ Leuproelin Acetate

LH-RH inductor microsphere technology

Filling

one month type

Sterilized solution

Published in the newspapers june, 2005

NEW
TAKEDASpin out from TAKEDA
To Contribute to world
HealthBy CEO MORIMOTO

～ Elderly care home ～Enormous time to care for patient
Copyright MORIMOTO Pharma LIMITED.

Social Problem of Crushing Tablet
In Care HomePatient①Loss of API②Reaction of API③Change of ADME
（to Change Efficacy, Side Effect）

Care Person ①Labor to process of Crushing,、②Hazard of Drug

Solve Problemby using Jelly

Special Lcture inJapan Pharmacy
Association inEhime

Take medicine with GT

Gel Together

Copyright MORIMOTO Pharma LIMITED.

Seal & Fold technology （patented）

Drug entrance＆Drinking side

Pill Location

GelSeal & Fold technology （patented）②Push outIN

①PillsEasy open seal

①Gel

②Push out

Seal & Fold technology （patented）◆ The medicine part is easily
opened by squeezing with2kg.
power.

◆GT can stand with pressure
more than 20kg when folded.

20kg

Easy open seal

Copyright MORIMOTO Pharma LIMITED.

GT pack & GT dosage form
1.

GT pack (Food)

2. GT dosage form（Medicine）①N②L③ Plus④ For
children

Copyright MORIMOTO Pharma LIMITED.

World’s first, Oral dosage form of W-bag
GT : Gel Together / Good Taste
What is “GT dosage form”
Pills and Gell are separated in a bag , to administer , squeeze the Gel
Compartment to combine Pills and Gel.

Open state
In a folded state
Copyright MORIMOTO Pharma LIMITED.

Variation of GT

powder wrappedby thin film
Powder medicine
CapsuleTabletCopyright MORIMOTO Pharma LIMITED.

1. Test result of water quantity and jelly amount necessary for ingestion（company data）
Amount of jelly&water（ml） 水
ゼ…

tablet（7 ）60
6050505050

40404040

必要量（ mL）

必要量（mL）

6060

水
水
Amountofjelly&water（ml）
ゼリー
ゼリー

30
30
2020
101000

水
ゼリー

33T

55T

The number77T

錠剤個数（個）watercapsule（1 号）

30302020101000113253
Thenumber
カプセル個数（個）Even though tablets increase,jelly can be taken in small
amounts.

mean  S.D.（N=10）

Morimoto jelly

23
Jelly
canbe
good
for swallowing using
カプセル個数（個）about one tenth of the amount of water

12. Water separation test result（compared to other jelly（company data））（morimoto jelly、A jelly、B jelly compared water percentage ;water by weight）◆ exhalation rate （initial stage）➢ sample:25g Only measure precipitation of moisture in jelly.

exhalation rate （initial stage）

Survey quality／total mass

jelly

The yieldof water

Test instruments

0.50

0.40
0.30

0.20

0.0%

5.9%0.0%

Morimoto jelly

A jelly

B jelly

0.100.0

Morimoto jelly was 0.0％ water by weight3．Physical property evaluation test result[Hardness, Adhesion､ Coagulability]（ Consumer Agency「Difficulty swallowing food Authorization Criteria」)「 Difficulty swallowing food test method」of「 permission for special use food 」 2001by GVM
病院食事例を基に策定された
平成２１年２月１２日食安発第０２１２００１号の許可基準分類

2０℃Adhesion

Hardness [N/m2][J/m3]

厚労省

Coagulability [-]
0.9

3000

2,512300

2500

0.72500.62000
200

0.5

1500

0.415096910006641000.770.827980 80

0.30.610.51（ Company data ）StandardACⅠACⅡACⅢHardness[N/m2]

2500～
10000

Adhesion[J/m3]～400～1000～1500

Coagulability[-]

0.2～0.6

0.2～0.9-

Difficultylevelhighmiddle

low1000～15000 300～20000

ACI Range value
Morimoto jelly
Ａ jelly
Ｂ jelly0.2

50050000.10

Morimoto jelly compliance with ACISociety classification 2013 (meal) Simplified chart（Japan swallowing Rehabilitation society）★Appropriate bolus★No water separation

From Healthy network URL：http://healthynetwork.co.jp/taiouzu/

Copyright MORIMOTO Pharma LIMITED.

Society classification 2013 (meal) Simplified chart
Dysphagia
Diet 0t

Dysphagia
Diet 0j

Jelly with low protein

Dysphagia
Diet 1jJelly , Pudding, Mousse

High-density thickness

0j
1j0t

j : jellyt : thickness

Considering physicalproperties, those withless water separation.
From Healthy network URL：http://healthynetwork.co.jp/taiouzu/Copyright MORIMOTO Pharma LIMITED.

Society classification 2013 (meal) Simplified chart
Non-sticky and Easy to coherent (Mixed food, Paste food)2-1

Dysphagia Diet

2-2

Homogenous
SmoothHeterogeneous
Including soft grains

Dysphagia Diet

3

Dysphagia Diet

4

No shape

Mash stew

Dysphagia Diet

A well stewed stew

Can be chewed withgums
And can form a bolus
Easy to cut with teeth
No stick to mouth or teeth.
Has pieces of shape things

From Healthy network URL：http://healthynetwork.co.jp/taiouzu/

Copyright MORIMOTO Pharma LIMITED.

Dissolution test
（Company data ）（社内データ）M Jelly
Water

Dissolution time

Adhesion and liquidity
test evaluation
food thickenerA
M Jelly M Jelly+water
Jelly

Other jelly→ Water separation
The reason of Accidental ingestionCopyright MORIMOTO Pharma LIMITED.

Dissolution test
（Company data ）（社内データ）M Jelly

test evaluation
food thickener

WaterWater

Adhesion and liquidity

AM Jelly M Jelly+water
Jelly

M Jelly

Dissolution time when it is shorter than water
Copyright MORIMOTO Pharma LIMITED.

Copyright MORIMOTO-IYAKU LIMITED.

Big Difference between Gel and Other Normal Jelly◆Jelly with Water Separationー ◆MORIMOTO GEL/ Patent

Normal Jelly
TabletSeparationm
Mis

Hold Pills
Make bolus
Easy Take

Uniformity
No Water
Separation
Copyright MORIMOTO-IYAKU LIMITED.

VF TEST of Pill in MORIMOTO GEL

ThanksHamamatsu
City
Rehabilitation
HospitalDr.
Fujishima
Dr.
Kanazawa。

Stability test（ Company data ）Room temperature long-term storage（measure at 20 ℃）
Study item Unit

4months

8months

2133

2011

1947

1995

1896

2207

2165

Coagulability -

0.53

0.51

0.58

0.61

0.62

0.60

0.61

Adhesion

J/㎥

588

488

378

446

438

550

605

-

3.75

3.76

3.76

3.70

3.73

3.66

3.77

0.41

0.03

0.07

HardnessｐＨ
Water
separation
Examination offood bacteria

N/㎡

Initial15months 23months 30months 38months%-Conformity Conformity Conformity Conformity Conformity Conformity Conformity

Three years stability
Copyright MORIMOTO Pharma LIMITED.

GT formulation（medical product）◆ Tablet＆Capsule case
◆Supplement case

◆ Children's use case (Mini-tablet)

20tablet

14tablet

8tabletCopyright MORIMOTO Pharma LIMITED.

GT for children (Weight adjustable dosage form)
Take out mini tablet
according to weight

14tablet

20tablet

8tablet※One mini tablet is equivalent to 1 kg of body weight
agebodyweight

Minitablet

036month month month
3kg

6kg

368kg

81old

2old

3old

4old

5old6old

10kg

12kg

14kg

16kg

18kg

20kg

10121618

14tablet20

Take out mini tablet according to weight
Copyright MORIMOTO-IYAKU LIMITED.

How to use

Insertmedicine

Fold drinking sidesqueeze jelly

Easy to carry！
Easy to take！
Hygienic！
hang down , not spill

Insert in mouth,
Take it

Extrude to thefront
Copyright MORIMOTO Pharma LIMITED.

「MORIMOTO Jelly」 Questionnaire Survey results◆Students from the University Faculty of Pharmacy

N=162

Copyright MORIMOTO Pharma LIMITED.

Summary
MORIMOTO JELLY is ;Stable and Palatability
Very good for people with swallowing difficulty ,such as elderly and infant and brain disease
Innovative for administration of medicine
To Provide with Solution for Social Problem suchas Drug Crushing in Nursing HomeGT technology is World first Technology
with Oral W-bag System for medicine ;Enhancement of compliance for drug taking
Easy swallowing safely and comfortably without water
Copyright MORIMOTO Pharma LIMITED.

Thank you for your attention

Want
Chinese and Asian Human Resources
Collaboration of R&D and Marketing

WECHAT

MORIMOTO Pharma.Co.,LtdPresident

SHUJI MORIMOTO
Copyright MORIMOTO Pharma LIMITED.