医 薬 薬 審 発 1127 第 １ 号
令 和 ５ 年 11 月 27 日
各都道府県衛生主管部（局）長

殿
厚生労働省医薬局医薬品審査管理課長
（
公
印
省
略
）

医薬品の一般的名称について標記については、｢医薬品の一般的名称の取扱いについて（平成 18 年３月 31 日薬
食発第 0331001 号厚生労働省医薬食品局長通知）｣等により取り扱っているところです。今般、我が国における医薬品の一般的名称（以下「JAN」という。）について、新たに別添のとおり定めたので、御了知の上、貴管下関係業者に周知方よろしく御配慮
願います。

（参照）
「日本医薬品一般的名称データベース」https://jpdb.nihs.go.jp/jan/（別添の情報のうち、JAN 以外の最新の情報は、当該データベースの情報で対応することとしています。
）

別添（別表２）INN に収載された品目の我が国における医薬品一般的名称（平成 18 年 3 月 31 日薬食審査発第 0331001 号厚生労働省医薬食品局審査管理課長通知に示す別表２）
登録番号 305-1-B6
JAN（日本名）：ザポメラン
JAN（英 名）：Zapomeran
核酸配列
GAUGGGCGGC GCAUGAGAGA AGCCCAGACC AAUUACCUAC CCAAAAUGGA50GAAAGUUCAC GUUGACAUCG AGGAAGACAG CCCAUUCCUC AGAGCUUUGC

100

AGCGGAGCUU CCCGCAGUUU GAGGUAGAAG CCAAGCAGGU CACUGAUAAU

150

GACCAUGCUA AUGCCAGAGC GUUUUCGCAU CUGGCUUCAA AACUGAUCGA200

AACGGAGGUG GACCCAUCCG ACACGAUCCU UGACAUUGGA AGUGCGCCCG250

CCCGCAGAAU GUAUUCUAAG CACAAGUAUC AUUGUAUCUG UCCGAUGAGA300UGUGCGGAAG AUCCGGACAG AUUGUAUAAG UAUGCAACUA AGCUGAAGAA350

AAACUGUAAG GAAAUAACUG AUAAGGAAUU GGACAAGAAA AUGAAGGAGC400UGGCCGCCGU CAUGAGCGAC CCUGACCUGG AAACUGAGAC UAUGUGCCUC

450

CACGACGACG AGUCGUGUCG CUACGAAGGG CAAGUCGCUG UUUACCAGGA500UGUAUACGCC GUCGACGGCC CCACCAGCCU GUACCACCAG GCCAACAAGG

550

GCGUGAGGGU GGCCUACUGG AUCGGCUUCG ACACCACACC CUUCAUGUUC600AAGAACCUGG CCGGCGCCUA CCCCAGCUAC AGCACCAACU GGGCCGACGA650

GACAGUGCUG ACCGCCAGGA ACAUCGGCCU GUGCAGCAGC GACGUGAUGG

700

AGAGGAGCCG GAGGGGCAUG AGCAUCCUGA GGAAGAAGUA CCUGAAGCCC

750

AGCAACAACG UGCUGUUCAG CGUGGGCAGC ACCAUCUACC ACGAGAAGAG800

GGACCUGCUG AGGAGCUGGC ACCUGCCCAG CGUGUUCCAC CUGAGGGGCA

850

AGCAGAACUA CACCUGCAGG UGCGAGACAA UCGUGAGCUG CGACGGCUAC

900

GUGGUGAAGA GGAUCGCCAU CAGCCCCGGC CUGUACGGCA AGCCCAGCGG

950

CUACGCCGCC ACCAUGCACA GGGAGGGCUU CCUGUGCUGC AAGGUGACCG 1000
ACACCCUGAA CGGCGAGAGG GUGAGCUUCC CCGUGUGCAC CUACGUGCCC 1050
GCCACCCUGU GCGACCAGAU GACCGGCAUC CUGGCCACCG ACGUGAGCGC 1100
CGACGACGCC CAGAAGCUGC UGGUGGGCCU GAACCAGAGG AUCGUGGUGA 1150
ACGGCAGGAC CCAGAGGAAC ACCAACACCA UGAAGAACUA CCUGCUGCCC 1200GUGGUGGCCC AGGCCUUCGC CAGGUGGGCC AAGGAGUACA AGGAGGACCA 1250
GGAGGACGAG AGGCCCCUGG GCCUGAGGGA CCGACAGCUG GUGAUGGGCU 1300

GCUGCUGGGC CUUCAGGCGG CACAAGAUCA CCAGCAUCUA CAAGAGGCCC 1350
GACACCCAGA CCAUCAUCAA GGUGAACAGC GACUUCCACA GCUUCGUGCU 1400
GCCCAGGAUC GGCAGCAACA CCCUGGAGAU CGGCCUGAGG ACCCGGAUCA 1450
GGAAGAUGCU GGAGGAGCAC AAGGAGCCCA GCCCUCUGAU CACCGCCGAG 1500
GACGUGCAGG AGGCCAAGUG CGCCGCCGAC GAGGCCAAGG AGGUGAGGGA 1550
GGCCGAGGAG CUGAGGGCCG CCCUGCCUCC CCUGGCCGCC GACGUGGAGG 1600
AGCCCACCCU GGAGGCCGAC GUGGACCUGA UGCUGCAGGA GGCCGGCGCC 1650
GGCAGCGUGG AGACACCCAG GGGCCUGAUC AAGGUGACCA GCUACGACGG 1700
CGAGGACAAG AUCGGCAGCU ACGCCGUGCU CAGCCCUCAG GCCGUGCUGA 1750
AGUCCGAGAA GCUGAGCUGC AUCCACCCUC UGGCCGAGCA GGUGAUCGUG 1800
AUCACCCACA GCGGCAGGAA GGGCAGGUAC GCCGUGGAGC CCUACCACGG 1850
CAAGGUGGUG GUCCCCGAGG GCCACGCCAU CCCCGUGCAG GACUUCCAGG 1900
CCCUGAGCGA GAGCGCCACC AUCGUGUAUA ACGAGAGGGA GUUCGUGAAC 1950
AGGUACCUGC ACCACAUCGC CACCCACGGC GGCGCCCUGA ACACCGACGA 2000
GGAGUACUAC AAGACCGUGA AGCCCAGCGA GCACGACGGC GAGUACCUGU 2050
ACGACAUCGA CAGGAAGCAG UGCGUGAAGA AGGAGCUGGU GACCGGCCUG 2100
GGCCUGACCG GCGAGCUGGU GGACCCUCCC UUCCACGAGU UCGCCUACGA 2150
GAGCCUGAGG ACCAGGCCCG CCGCUCCCUA CCAGGUGCCC ACCAUCGGCG 2200
UGUACGGCGU GCCCGGCAGC GGCAAGAGCG GCAUCAUCAA GAGCGCCGUG 2250
ACCAAGAAGG ACCUGGUGGU GAGCGCCAAG AAGGAGAACU GCGCCGAGAU 2300
CAUCAGGGAC GUGAAGAAGA UGAAGGGCCU GGACGUGAAC GCCAGGACCG 2350
UGGACAGCGU GCUCCUGAAC GGCUGCAAGC ACCCCGUGGA GACACUGUAU 2400
AUCGACGAGG CCUUCGCCUG CCACGCCGGC ACCCUGAGGG CCCUGAUCGC 2450
CAUCAUCAGG CCCAAGAAGG CCGUGCUGUG CGGCGACCCC AAGCAGUGCG 2500
GCUUCUUCAA CAUGAUGUGC CUGAAGGUGC ACUUCAACCA CGAGAUCUGC 2550
ACCCAGGUGU UCCACAAGAG CAUCAGCAGG CGGUGCACCA AGAGCGUGAC 2600
CAGCGUGGUG AGCACCCUGU UCUACGACAA GAAGAUGAGG ACCACCAACC 2650
CCAAGGAGAC AAAGAUCGUG AUCGACACCA CCGGCAGCAC CAAGCCCAAG 2700
CAGGACGACC UGAUCCUGAC CUGCUUCAGG GGCUGGGUGA AGCAGCUGCA 2750
GAUCGACUAC AAGGGCAACG AGAUCAUGAC CGCCGCCGCU AGCCAGGGCC 2800
UGACCAGGAA GGGCGUGUAC GCCGUGAGGU ACAAGGUGAA CGAGAAUCCC 2850
CUGUACGCCC CUACCAGCGA GCACGUGAAC GUCCUGCUGA CCAGGACCGA 2900
GGACAGGAUC GUGUGGAAGA CCCUGGCCGG CGACCCCUGG AUCAAGACCC 2950

UGACCGCCAA GUACCCCGGC AACUUCACCG CCACCAUCGA GGAGUGGCAG 3000
GCCGAGCACG ACGCCAUCAU GAGGCACAUC CUGGAGAGGC CCGACCCCAC 3050
CGACGUGUUC CAGAACAAGG CCAACGUGUG CUGGGCCAAG GCCCUGGUGC 3100
CCGUGCUGAA GACCGCCGGC AUCGACAUGA CCACCGAGCA GUGGAACACC 3150
GUGGACUACU UCGAGACAGA CAAGGCCCAC AGCGCCGAGA UCGUGCUGAA 3200
CCAGCUGUGC GUGAGGUUCU UCGGCCUGGA CCUGGACAGC GGCCUGUUCA 3250
GCGCCCCUAC CGUGCCCCUG AGCAUCAGGA ACAACCACUG GGACAACAGC 3300
CCCAGCCCCA ACAUGUACGG CCUGAACAAG GAGGUGGUGA GGCAGCUGAG 3350
CAGGCGGUAC CCUCAGCUGC CCAGGGCCGU GGCCACCGGC AGGGUGUACG 3400
ACAUGAACAC CGGCACCCUG AGGAACUACG ACCCCAGGAU CAACCUGGUG 3450
CCCGUGAACA GGCGGCUGCC ACACGCCCUG GUGCUGCACC ACAACGAGCA 3500
CCCUCAGAGC GACUUCAGCA GCUUCGUGAG CAAGCUGAAG GGCAGGACCG 3550
UGCUGGUGGU GGGCGAGAAG CUGAGCGUGC CCGGCAAGAU GGUGGACUGG 3600
CUGAGCGACA GGCCCGAGGC CACCUUCCGG GCCAGGCUGG ACCUGGGCAU 3650
CCCCGGCGAC GUGCCCAAGU ACGACAUCAU CUUCGUGAAC GUGAGGACCC 3700
CUUACAAGUA CCACCACUAC CAGCAGUGCG AGGACCACGC CAUCAAGCUG 3750
AGCAUGCUGA CCAAGAAGGC CUGCCUGCAC CUGAACCCCG GCGGCACCUG 3800
CGUGAGCAUC GGCUACGGCU ACGCCGACAG GGCCAGCGAG AGCAUCAUCG 3850
GCGCCAUCGC CAGGCUGUUC AAGUUCAGCA GGGUGUGCAA GCCCAAGAGC 3900
AGCCUGGAGG AGACAGAGGU GCUGUUCGUG UUCAUCGGCU ACGACCGGAA 3950
GGCCAGGACC CACAACCCCU ACAAGCUGAG CAGCACCCUG ACCAACAUCU 4000
ACACCGGCAG CAGGCUGCAC GAGGCCGGCU GCGCCCCUAG CUACCACGUG 4050
GUGAGGGGCG ACAUCGCCAC CGCCACCGAG GGCGUGAUCA UCAACGCCGC 4100
CAACAGCAAG GGCCAGCCCG GCGGCGGGGU GUGCGGCGCC CUGUAUAAGA 4150
AGUUCCCCGA GAGCUUCGAC CUGCAGCCCA UCGAGGUGGG CAAGGCCAGG 4200
CUGGUGAAGG GCGCCGCCAA GCACAUCAUC CACGCCGUGG GCCCCAACUU 4250
CAACAAGGUG AGCGAGGUGG AGGGCGACAA GCAGCUGGCC GAGGCCUACG 4300
AGAGCAUCGC CAAGAUCGUG AACGACAACA ACUACAAGAG CGUGGCCAUC 4350
CCUCUGCUGA GCACCGGCAU CUUCAGCGGC AACAAGGACA GGCUGACCCA 4400
GAGCCUGAAC CACCUGCUGA CCGCCCUGGA CACCACCGAC GCCGACGUGG 4450
CCAUCUACUG CAGGGACAAG AAGUGGGAGA UGACCCUGAA GGAGGCCGUG 4500
GCCAGGCGGG AGGCCGUGGA GGAGAUCUGC AUCAGCGACG ACAGCAGCGU 4550
GACGGAGCCC GACGCCGAGC UGGUGAGGGU GCACCCCAAG AGCAGCCUGG 4600

CCGGCAGGAA GGGCUACAGC ACCAGCGACG GCAAGACCUU CAGCUACCUG 4650
GAGGGCACCA AGUUCCACCA GGCCGCCAAG GACAUCGCCG AGAUCAACGC 4700
CAUGUGGCCC GUGGCCACCG AGGCCAACGA GCAGGUGUGC AUGUAUAUCC 4750
UGGGCGAGAG CAUGAGCAGC AUCAGGAGCA AGUGCCCCGU GGAGGAGAGC 4800
GAGGCCAGCA CCCCUCCCAG CACCCUGCCC UGCCUGUGCA UCCACGCCAU

4850

GACCCCUGAG AGGGUGCAGC GGCUGAAGGC CAGCAGGCCC GAGCAGAUCA 4900
CCGUGUGCAG CAGCUUCCCU CUGCCCAAGU ACCGGAUCAC CGGCGUGCAG 4950
AAGAUCCAGU GCAGCCAGCC CAUCCUGUUC AGCCCCAAGG UGCCCGCCUA 5000
CAUCCACCCC AGGAAGUACC UGGUGGAGAC ACCCCCCGUG GACGAGACAC 5050
CCGAGCCCAG CGCCGAGAAC CAGAGCACCG AGGGCACCCC UGAGCAGCCU 5100
CCCCUGAUCA CCGAGGACGA GACAAGGACC AGGACGCCCG AGCCCAUCAU 5150
CAUUGAGGAG GAAGAGGAGG ACAGCAUCAG CCUGCUGAGC GACGGCCCCA 5200
CCCACCAGGU GCUGCAGGUG GAGGCCGACA UCCACGGCCC UCCCAGCGUG 5250
AGCAGCUCCA GCUGGAGCAU CCCUCACGCC AGCGACUUCG ACGUGGACAG 5300
CCUGAGCAUC CUGGACACCC UGGAGGGCGC CAGCGUGACC AGCGGCGCCA 5350
CCAGCGCCGA GACAAACAGC UACUUCGCCA AGAGCAUGGA GUUCCUGGCC 5400
AGGCCCGUGC CCGCCCCUAG GACCGUGUUC AGGAACCCUC CCCACCCCGC 5450
CCCUAGGACC AGGACCCCUA GCCUGGCCCC UAGCAGGGCC UGCAGCAGGA 5500
CCAGCCUGGU GAGCACCCCU CCCGGCGUGA ACCGGGUGAU CACCAGGGAG 5550
GAGCUGGAGG CCCUGACCCC UAGCAGGACC CCUAGCAGGA GCGUGAGCAG 5600
GACCAGCCUG GUGAGCAACC CUCCCGGCGU GAACCGGGUG AUCACCAGGG 5650
AGGAGUUCGA GGCCUUCGUG GCCCAGCAGC AAAGGCGGUU CGACGCCGGC 5700
GCCUACAUCU UCAGCAGCGA CACCGGCCAG GGCCACCUGC AGCAGAAGUC 5750
CGUGAGGCAG ACCGUGCUGA GCGAGGUGGU CCUGGAGAGG ACGGAGCUGG 5800
AGAUCAGCUA CGCCCCUAGG CUGGACCAGG AGAAGGAGGA GCUGCUGAGG 5850
AAGAAGCUGC AGCUGAACCC CACCCCUGCC AACAGGAGCA GGUACCAGAG 5900
CAGGAAGGUG GAGAACAUGA AGGCCAUCAC CGCCAGGCGG AUCCUGCAGG 5950
GCCUGGGCCA CUACCUGAAG GCCGAGGGCA AGGUGGAGUG CUACAGGACC 6000
CUGCACCCCG UGCCCCUGUA CUCCAGCUCC GUGAACAGGG CCUUCAGCAG 6050
CCCCAAGGUG GCCGUGGAGG CCUGCAACGC CAUGCUGAAG GAGAACUUCC 6100
CCACCGUGGC CAGCUACUGC AUCAUCCCCG AGUACGACGC CUACCUGGAC 6150
AUGGUGGACG GCGCCAGCUG CUGCCUGGAC ACCGCCAGCU UCUGCCCCGC 6200
CAAGCUGAGG AGCUUCCCCA AGAAGCACAG CUACCUGGAG CCCACCAUCA 6250

GGAGCGCCGU GCCCAGCGCC AUCCAGAACA CCCUGCAGAA CGUGCUGGCC

6300

GCCGCUACCA AGAGGAACUG CAACGUGACC CAGAUGAGGG AGCUGCCCGU 6350
GCUGGACAGC GCCGCCUUCA ACGUGGAGUG CUUCAAGAAG UACGCCUGCA 6400
ACAACGAGUA CUGGGAGACA UUCAAGGAGA ACCCCAUCAG GCUGACCGAG 6450
GAGAACGUGG UGAACUACAU CACCAAGCUG AAGGGCCCCA AGGCCGCCGC 6500
UCUGUUCGCC AAGACCCACA ACCUGAACAU GCUCCAGGAC AUCCCUAUGG 6550
ACAGGUUCGU GAUGGACCUG AAGAGGGACG UGAAGGUGAC CCCUGGCACC 6600
AAGCACACCG AGGAGAGGCC CAAGGUGCAG GUGAUCCAGG CCGCCGACCC 6650
UCUGGCCACC GCCUACCUGU GCGGCAUCCA CAGGGAGCUG GUGAGGCGGC 6700
UGAACGCCGU CCUGCUGCCC AACAUCCACA CCCUGUUCGA CAUGAGCGCC 6750
GAGGACUUCG ACGCCAUCAU CGCCGAGCAC UUCCAGCCCG GCGACUGCGU 6800
GCUGGAGACA GACAUCGCCA GCUUCGACAA GAGCGAGGAC GACGCUAUGG 6850
CCCUGACCGC CCUGAUGAUC CUGGAGGACC UGGGCGUGGA CGCCGAGCUG 6900
CUGACCCUGA UCGAGGCCGC CUUCGGCGAG AUCAGCAGCA UCCACCUGCC 6950
CACCAAGACC AAGUUCAAGU UCGGCGCCAU GAUGAAGUCC GGCAUGUUCC 7000
UGACCCUGUU CGUGAACACC GUGAUCAACA UCGUGAUCGC CAGCAGGGUG 7050
CUGCGGGAGA GGCUGACCGG CAGCCCCUGC GCCGCCUUCA UCGGCGACGA 7100
CAACAUCGUG AAGGGCGUGA AGUCCGACAA GCUGAUGGCC GACAGGUGCG 7150
CCACCUGGCU GAACAUGGAG GUGAAGAUCA UCGACGCCGU GGUGGGCGAG 7200
AAGGCCCCUU ACUUCUGCGG CGGCUUCAUC CUGUGCGACA GCGUGACCGG 7250
CACCGCCUGC AGGGUGGCCG ACCCUCUGAA GAGGCUGUUC AAGCUGGGCA 7300
AGCCCCUGGC CGCCGACGAC GAGCACGACG ACGAUAGGCG GAGGGCCCUG

7350

CACGAGGAGA GCACCAGGUG GAACCGGGUG GGCAUCCUGA GCGAGCUGUG 7400
CAAGGCCGUG GAGAGCAGGU ACGAGACAGU GGGCACCAGC AUCAUCGUGA 7450
UGGCCAUGAC CACCCUGGCC AGCAGCGUCA AGUCCUUCAG CUACCUGAGG 7500
GGGGCCCCUA UAACUCUCUA CGGCUAACCU GAAUGGACUA CGACAUAGUC 7550
UAGUCCGCCA AGGCCGCCAC CAUGUUCGUG UUCCUGGUGC UGCUGCCCCU 7600
GGUGUCUAGC CAGUGCGUGA ACCUGACCAC CAGGACCCAG CUGCCUCCCG 7650
CCUACACCAA CAGCUUCACC AGGGGCGUGU ACUACCCCGA CAAGGUGUUC 7700
AGGAGCAGCG UGCUGCACAG CACCCAGGAC CUGUUCCUGC CCUUCUUCAG 7750
CAACGUGACC UGGUUCCACG CCAUCCACGU GAGCGGCACC AACGGCACCA 7800
AGAGGUUCGA CAACCCCGUG CUGCCCUUCA ACGACGGCGU GUACUUCGCC 7850
AGCACCGAGA AGUCCAACAU CAUCAGGGGC UGGAUCUUCG GCACCACCCU 7900

GGACAGCAAG ACCCAGAGCC UGCUGAUCGU GAACAACGCC ACCAACGUGG 7950
UGAUCAAGGU GUGCGAGUUC CAGUUCUGCA ACGACCCCUU CCUGGGCGUG 8000
UACUACCACA AGAACAACAA GAGCUGGAUG GAGAGCGAGU UCAGGGUGUA 8050
CUCCAGCGCC AACAACUGCA CCUUCGAGUA CGUGAGCCAG CCCUUCCUGA 8100
UGGACCUGGA GGGCAAGCAG GGCAACUUCA AGAACCUGAG GGAGUUCGUG 8150
UUCAAGAACA UCGACGGCUA CUUCAAGAUC UACAGCAAGC ACACCCCUAU 8200
CAACCUGGUG AGGGACCUGC CCCAGGGCUU CAGCGCCCUG GAGCCCCUGG 8250
UGGACCUGCC CAUCGGCAUC AACAUCACCA GGUUCCAGAC CCUGCUGGCC 8300
CUGCACAGGA GCUACCUGAC CCCUGGCGAC AGCAGCUCCG GCUGGACCGC 8350
CGGCGCCGCC GCUUACUACG UGGGCUACCU GCAGCCCAGG ACCUUCCUGC 8400
UGAAGUACAA CGAGAACGGC ACCAUCACCG ACGCCGUGGA CUGCGCCCUG 8450
GACCCUCUGA GCGAGACAAA GUGCACCCUG AAGUCCUUCA CCGUGGAGAA 8500
GGGCAUCUAC CAGACCAGCA ACUUCAGGGU GCAGCCCACC GAGAGCAUCG 8550
UGAGGUUCCC CAACAUCACC AACCUGUGCC CCUUCGGCGA GGUGUUCAAC 8600
GCCACCAGGU UCGCCAGCGU GUACGCCUGG AACAGGAAGA GGAUCAGCAA 8650
CUGCGUGGCC GACUACAGCG UGCUGUAUAA CAGCGCCAGC UUCAGCACCU 8700
UCAAGUGCUA CGGCGUGAGC CCCACCAAGC UGAACGACCU GUGCUUCACC 8750
AACGUGUACG CCGACAGCUU CGUGAUCAGG GGCGACGAGG UGAGGCAGAU 8800
CGCCCCUGGC CAGACCGGCA AGAUCGCCGA CUACAACUAC AAGCUGCCCG 8850
ACGACUUCAC CGGCUGCGUG AUCGCCUGGA ACAGCAACAA CCUGGACAGC 8900
AAGGUGGGCG GCAACUACAA CUACCUGUAC CGGCUGUUCA GAAAGAGCAA 8950
CCUGAAGCCC UUCGAGAGGG ACAUCAGCAC CGAGAUCUAC CAGGCCGGCA 9000
GCACCCCUUG CAACGGCGUG GAGGGCUUCA ACUGCUACUU CCCUCUGCAG 9050
AGCUACGGCU UCCAGCCCAC CAACGGCGUG GGCUACCAGC CCUACAGGGU 9100
GGUGGUCCUG AGCUUCGAGC UGCUGCACGC CCCUGCCACC GUGUGCGGCC 9150
CCAAGAAGUC CACCAACCUG GUGAAGAACA AGUGCGUGAA CUUCAACUUC 9200
AACGGCCUGA CCGGCACCGG CGUGCUGACC GAGAGCAACA AGAAGUUCCU 9250
GCCCUUCCAG CAGUUCGGCA GGGACAUCGC CGACACCACC GACGCCGUGA 9300
GGGACCCUCA GACCCUGGAG AUCCUGGACA UCACCCCUUG CAGCUUCGGC 9350
GGCGUGAGCG UGAUCACCCC UGGCACCAAC ACCAGCAACC AGGUGGCCGU 9400
GCUGUACCAG GGCGUGAACU GCACCGAGGU GCCCGUGGCC AUCCACGCCG 9450
ACCAGCUGAC CCCUACCUGG AGGGUGUACU CCACCGGCAG CAACGUGUUC 9500
CAGACCAGGG CCGGCUGCCU GAUCGGCGCC GAGCACGUGA ACAACAGCUA 9550

CGAGUGCGAC AUCCCCAUCG GCGCCGGCAU CUGCGCCAGC UACCAGACCC 9600
AGACCAACAG CCCCGGGAGC GCCAGCAGCG UGGCCAGCCA GAGCAUCAUC 9650
GCCUACACCA UGAGCCUGGG CGCCGAGAAC AGCGUGGCCU ACAGCAACAA 9700
CAGCAUCGCC AUCCCCACCA ACUUCACCAU CAGCGUGACC ACCGAGAUCC 9750
UGCCCGUGAG CAUGACCAAG ACCAGCGUGG ACUGCACCAU GUAUAUCUGC 9800
GGCGACAGCA CCGAGUGCAG CAACCUGCUG CUCCAGUACG GCAGCUUCUG 9850
CACCCAGCUG AACAGGGCCC UGACCGGCAU CGCCGUGGAG CAGGACAAGA 9900
ACACCCAGGA GGUGUUCGCC CAGGUGAAGC AGAUCUACAA GACCCCUCCC 9950
AUCAAGGACU UCGGCGGCUU CAACUUCAGC CAGAUCCUGC CCGACCCCAG 10000
CAAGCCCAGC AAGAGGAGCU UCAUCGAGGA CCUGCUGUUC AACAAGGUGA 10050
CCCUGGCCGA CGCCGGCUUC AUCAAGCAGU ACGGCGACUG CCUGGGCGAC 10100
AUCGCCGCCA GGGACCUGAU CUGCGCCCAG AAGUUCAACG GCCUGACCGU 10150
GCUGCCUCCC CUGCUGACCG ACGAGAUGAU CGCCCAGUAC ACCAGCGCCC 10200
UGCUGGCCGG CACCAUCACC AGCGGCUGGA CCUUCGGCGC CGGCGCCGCC 10250
CUGCAGAUCC CCUUCGCCAU GCAGAUGGCC UACAGGUUCA ACGGCAUCGG 10300
CGUGACCCAG AACGUGCUGU ACGAGAACCA GAAGCUGAUC GCCAACCAGU 10350
UCAACAGCGC CAUCGGCAAG AUCCAGGACA GCCUGAGCAG CACCGCCAGC 10400
GCCCUGGGCA AGCUGCAGGA CGUGGUGAAC CAGAACGCCC AGGCCCUGAA 10450
CACCCUGGUG AAGCAGCUGA GCAGCAACUU CGGCGCCAUC AGCAGCGUGC 10500
UGAACGACAU CCUGAGCAGG CUGGACCCAC CCGAGGCCGA GGUGCAGAUC 10550
GACAGGCUGA UCACCGGCAG GCUGCAGAGC CUGCAGACCU ACGUGACCCA 10600
GCAGCUGAUC AGGGCCGCCG AGAUCAGGGC CAGCGCCAAC CUGGCCGCCA 10650
CCAAGAUGAG CGAGUGCGUG CUGGGCCAGA GCAAGAGGGU GGACUUCUGC 10700
GGCAAGGGCU ACCACCUGAU GAGCUUCCCU CAGAGCGCCC CUCACGGCGU 10750
GGUGUUCCUG CACGUGACCU ACGUGCCCGC CCAGGAGAAG AACUUCACCA 10800
CAGCCCCUGC CAUCUGCCAC GACGGCAAGG CCCACUUCCC CAGGGAGGGC 10850
GUGUUCGUGA GCAACGGCAC CCACUGGUUC GUGACCCAGA GGAACUUCUA 10900
CGAGCCCCAG AUCAUCACCA CCGACAACAC CUUCGUGAGC GGCAACUGCG 10950
ACGUGGUGAU CGGCAUCGUG AACAACACCG UGUACGACCC UCUGCAGCCC 11000
GAGCUGGACA GCUUCAAGGA GGAGCUGGAC AAGUACUUCA AGAACCACAC 11050
CAGCCCCGAC GUGGACCUGG GCGACAUCAG CGGCAUCAAC GCCAGCGUGG 11100
UGAACAUCCA GAAGGAGAUC GACAGGCUGA ACGAGGUGGC CAAGAACCUG 11150
AACGAGAGCC UGAUCGACCU GCAGGAGCUG GGCAAGUACG AGCAGUACAU 11200

CAAGUGGCCC UGGUACAUCU GGCUGGGCUU CAUCGCCGGC CUGAUCGCCA 11250
UCGUGAUGGU GACCAUCAUG CUGUGCUGCA UGACCAGCUG CUGCAGCUGC 11300
CUGAAGGGCU GCUGCAGCUG CGGCAGCUGC UGCAAGUUCG ACGAGGACGA 11350
CAGCGAGCCC GUGCUGAAGG GCGUGAAGCU GCACUACACC UAAACUCGAG 11400
UAUGUUACGU GCAAAGGUGA UUGUCACCCC CCGAAAGACC AUAUUGUGAC 11450
ACACCCUCAG UAUCACGCCC AAACAUUUAC AGCCGCGGUG UCAAAAACCG 11500
CGUGGACGUG GUUAACAUCC CUGCUGGGAG GAUCAGCCGU AAUUAUUAUA 11550
AUUGGCUUGG UGCUGGCUAC UAUUGUGGCC AUGUACGUGC UGACCAACCA 11600
GAAACAUAAU UGAAUACAGC AGCAAUUGGC AAGCUGCUUA CAUAGAACUC 11650
GCGGCGAUUG GCAUGCCGCC UUAAAAUUUU UAUUUUAUUU UUUCUUUUCU 11700
UUUCCGAAUC GGAUUUUGUU UUUAAUAUUU CAAAAAAAAA AAAAAAAAAA 11750
AAAAAAUCUA GAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 11800
AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 11850
AAAAAAAAAA A

11861

A = アデノシン； C = シチジン； G = グアノシン； U = ウリジン
1-3：5’キャップ構造部分
4-45：5’非翻訳領域（16-45：ベネズエラ馬脳炎ウイルス遺伝子 5’非翻訳領域由来の配列）
46-7527：ベネズエラ馬脳炎ウイルス RNA 依存性 RNA ポリメラーゼの翻訳領域（46-48：開始コドン；75257527：終止コドン）
7528-7571：intergenic region（サブゲノム RNA 産生に関わるプロモーター配列の一部を含む）
7572-11393：SARS-CoV-2 のスパイクタンパク質類縁体の翻訳領域（7572-7574：開始コドン；7575-7610：
SARS-CoV-2 スパイクタンパク質のシグナルペプチド；11391-11393：終止コドン）
11394-11731：3’非翻訳領域（ベネズエラ馬脳炎ウイルス遺伝子 3’非翻訳領域由来の配列）
11732-11861：ポリ A 転写スリップ

5’キャップ構造部分
NH2
N

N

N
O

O

P

O

O O

P

O

P

O O

O
O

H

O
H

H
H3C

NH

O
N

N

O

NH2

O
H
H

NH

H
O CH
3
O
O
P

O

N

N

O

N

O

O

H

H

H

H
O

OH

H
H

OH OH

RNA

ザポメランは，ベネズエラ馬脳炎ウイルス RNA レプリカーゼ（nsP1，nsP2，nsP3，nsP4）及び SARS-CoV2 のスパイクタンパク質類縁体（D614G，R682G，R683S，R685S，K986P，V987P）全長をコードする自己複製型 mRNA である．ザポメランは，5’キャップ構造，サブゲノムプロモーター配列，及びポリ A 配列を含む，11861 個のヌクレオチド残基からなる 1 本鎖 RNA である．

Zapomeran is a self-replicating mRNA encoding Venezuelan equine encephalitis virus RNA replicase (nsP1, nsP2,
nsP3, nsP4) and full length of spike protein analog (D614G, R682G, R683S, R685S, K986P, V987P) of SARS-CoV2. Zapomeran is a single-stranded RNA consisting of 11861 nucleotide residues including the 5’ cap structure,subgenomic promoter and poly A sequence.

※

JAN 以外の情報は、参考として掲載しました。