EPO-TEK® MED-353ND
Technical Data Sheet
For Reference Only
Biocompatible/High Temperature Epoxy

ISO 10993 Tested/Fully Compliant
Date:
Rev:
No. of Components:
Mix Ratio by Weight:
Specific Gravity:
Pot Life:
Shelf Life- Bulk:
Shelf Life- Syringe

February 2021
VITwo
10 : 1
Part A: 1.20 Part B: 1.02
Syringe: 1.19
≤ 3 Hours
One year at room temperature
6 months at -40°C

Biocompatible Certified Cure: 150°C / 1.5 Hours
Alternative biocompatible cure schedules may be possible,
but have not been certified. Contact med@epotek.com
with any questions.

NOTES:● Container(s) should be kept closed when not in use.
● Filled systems should be stirred thoroughly before mixing and prior to use.
● Performance properties (rheology, conductivity, others) of the product may vary from those stated on the data sheet when bi-pak/syringe packaging or
post-processing of any kind is performed. Epoxy’s warranties shall not apply to any products that have been reprocessed or repackaged from Epoxy’s
delivered status/container into any other containers of any kind, including but not limited to syringes, bi-paks, cartridges, pouches, tubes, capsules, films
or other packages.
● Syringe packaging will impact initial viscosity and effective pot life, potentially beyond stated parameters.
● If product crystalizes in storage, place container in warm oven until crystallization disappears. Please refer to Tech Tip #7 on website.
● TOTAL MASS SHOULD NOT EXCEED 25 GRAMS

Product Description: EPO-TEK® MED-353ND is a biocompatible, high temperature, high Tg, and high strength epoxy. It has decadesof use and reliability in medical device designs worldwide. Medical applications span from fiber optics and endoscopes, to implants, todiagnostic equipment, to imaging modalities, to surgical tooling. It has high adhesion to SST, titanium, ceramics, glass and most plastic,
as well as high chemical and moisture resistance.
Typical Properties: Cure condition: 150°C / 1.5 Hours
Different batches, conditions & applications yield differing results.
Data below is not guaranteed. To be used as a guide only, not as a specification. * denotes test on lot acceptance basis
PHYSICAL PROPERTIES:* Color (before cure):* Consistency:* Viscosity (23°C) @ 50 rpm:
Thixotropic Index:* Glass Transition Temp:
Coefficient of Thermal Expansion (CTE):
Below Tg:
Above Tg:
Shore D Hardness:
Lap Shear @ 23°C:
Die Shear @ 23°C:
Degradation Temp:
Weight Loss:@ 200°C:@ 250°C:@ 300°C:
Suggested Operating Temperature:
Storage Modulus:* Particle Size:
OPTICAL PROPERTIES:Spectral Transmission:
Refractive Index:

Part A: Clear
Part B: Amber
Pourable liquid
3,000-5,000 cPs
N/A≥ 90 °C (Dynamic Cure: 20-200°C/ISO 25 Min; Ramp -10-200°C @20°C/Min)
51178
85> 2,000≥ 10413
0.48
0.74
1.27
< 350464,126
N/A> 89% @ 860-1600
1.5701 @589

x 10-6 in/in°C
x 10-6 in/in°C
psiKg°C

3,556 psi%%%°C (Intermittent)
psinm
nm

Epoxies and Adhesives for Demanding Applications™
This information is based on data and tests believed to be accurate. Epoxy Technology, Inc. makes no warranties (expressed or implied) as toits accuracy and assumes no liability in connection with any use of this product.
EPOXY TECHNOLOGY, INC.
14 FORTUNE DRIVE, BILLERICA, MA 01821 (978) 667-3805, FAX (978) 663-9782
www.epotek.com
A Meridian Adhesives Group Companyepotek.com

Selected Applications for EPO-TEK® MED-353ND
Fiber and Electro-Optics

Device and Diagnostics• Impregnating and terminating fiber optic image bundles and light guides,
adhesive for flexible endoscopes, adhesion to plastic and glass optical fibers,
structural and near hermetic sealing of glass, ceramic and metals• Manufacture of all kinds of endoscopes, such as, laryngoscopes, gastroscopes,
broncho-scopes and micro ophthalmoscopes; healthcare optics forcolonoscopy, urology, and otolaryngology• Sensor integration and subcomponents for respiratory, anesthesia, vapor andsuction; gas and liquid flow monitoring• SpO2 patient monitoring; capnography, gas analyzers and flow meters• Widely used adhesive for pressure and pH monitoring catheters

Implantable Devices• Subcomponents for Ventricular Assist Devices (VAD) fabrication including
pumps, coils and magnets• Adhesive for ophthalmic implants; plastic bonding in intraocular lens (IOL)
Micro sensors for intraocular pressure• Hearing aids and implants; acoustic circuits and structural assembly• Enabling neurostimulator technologies used for sleep apnea,
bladder control and other conditions• Adhesive for pacemakers, ICDs and IPGs
• Neurovascular implants treating aneurysm, stroke, epilepsy andParkinson’s Disease

Imaging Technologies• OCT using NIR laser for cardiac and ophthalmic imaging• Endoscopy with camera and video interface• Ultrasound imaging, capsule endoscopes for GI tract viewing and monitoring• Temperature probes integration, subcomponent bonding and final assemblyof MRI and CT machines

Ultrasound / Ultrasonic• Adhesive for catheter delivered surgical mapping. 3D imaging and mapping
catheters; catheter ultrasound for cardiac therapy, such as AFib treatments• Front-end ultrasound fabrication adhesive responsible for PZT arrays• Back-end PZT processes enabling transducers, ultrasound probe
repair adhesive

Surgical Tools• High power laser optics for general, reconstructive and cosmetic surgery• Dental device adhesive, lighting or hand instrument• Adhesive for neurovascular surgical delivery systems and coils fortreating aneurysms• Fabrication of Rf Ablation catheters, electro-surgical tool fortissue removal• Laser for peripheral artery disease (PAD); atherectomy technologies• Impregnating coil motors in orthopedic bone saws

Life Sciences and MicroFluidics• DNA and gene sequencers, readers and amplification circuits• Potting, over-coating and weather proofing, fitness style wrist watches andwearable devices

Strength of MED-353ND with Disinfectant Soaking
MED 353ND Glutaraldehyde (GA)MED-353ND Peracetic Acid (PAA)4035

MED-353ND Test Parameters

3030• Adhesive cured: 150°C/1hr2525• Surfaces: 2mm x 2mm ceramic onto glass substrates

Force (kg)3520

• # of estimated cycles based on retaining 50% of initial strength15• 1 cycle defined as 20 min exposure

1010• 360 cycles (5d) for GA - estimated55• 500 cycles for PAA - estimated1500.042

125Exposure (day[s])70Control

0.042

20181620
1418
1216
10148
126
104
82
60
4
20MED-353ND on PC

Control(Before Placement)

1hr Delay Time
Control
5hr Delay Time
(Before Placement)

1hr Delay Time
5hr Delay Time
Control(Before Placement)

Control

11hr Delay TimeControl
5hr Delay Time

5Die Shear
Die (kg)
Shear (kg)Die Shear
Die (kg)
Shear (kg)on PC to Various Plastics
MED-353NDMED-353ND
Bonding Strength(Before Placement)

Treatment Time (min)15Control

MED-353ND on PEIControl(Before Placement)

1hr Delay Time
Control
5hr
Delay Time
(Before Placement)

1hr Delay Time
Control
5hr Delay Time

Control
15Treatment Time (min)Control
15MED-353ND Test
Conditions
Treatment
Time (min)(Before Placement)

1hr Delay Time
Control
5hr
Delay Time
(Before Placement)

1hr Delay Time
5hr Delay TimeDie Shear
Die (kg)
Shear (kg)MED-353ND on PEI

25302025152010155100501hr Delay Time
5hr Delay Time

Treatment Time (min)353035253020251520101551005030

125Exposure (day[s])7Index of Refraction vs. Wavelength EPO-TEK® MED-353ND

MED-353ND on PEEK

Index of Refraction vs. Wavelength EPO-TEK MED 353ND

MED-353ND on PEEK

1.60

λ=0.589

λ=1.00λ=1.551.59

1.5831

1.58

Control

15Treatment Time (min)Control
151.56
1.55
1.54

MED-353ND on PPS

1.53

3530
MED-353ND on PPS
3525302025152010155100Control
155Treatment Time (min)0Control
15Treatment Time (min)• 12 chips per substrate• Surfaces: 2mm x 2mm ceramic onto plastics• Delay time = the duration after plasma etch,
before die placement• 1min and 5 min exposure time comparison

1.5726

1.57

Treatment Time (min)• Adhesive cured: 150°C/1hrs (PEEK, PEI),
135°C/1.5hrs (PPS), 110°C/2hrs (PC)• Oxygen plasma, 100ml/min flow rate

Control

Index of Refraction

20Die ShearDie (kg)Shear (kg)Force (kg)4000.5

11.5

2

Wavelength (µm)

Epoxy Technology Inc.

14 Fortune Drive • Billerica, MA 01821
phone 978-667-3805 fax 978-663-9782
med@epotek.com© Epoxy Technology Inc. 2018

Biocompatibility Approvals®

• EPO-TEK MED-353ND cured at 150°C for 1.5 hours has been tested and is ISO 10993 Certified, meeting Hemolysis (10993-4), Cytotoxicity (10993-5),
Implantation (10993-6) Intracutaneous (10993-10), Sensitization (10993-10) and Systemic Toxicity (10993-11) test protocols.

Sterilization Information• Epoxy performance is most influenced by surface preparation and cleanliness, overall process and handling, and finally proper curing selection. While bulk
samples of MED-353ND may resist sterilization technologies such as autoclave steam, gaseous technologies, gamma radiation as well as liquid disinfectants,
the glue joints may differ. All users need to determine the suitability of MED-353ND for their given application.
• MED-353ND was found compatible with 100 cycles of Sterrad 100NX at standard concentration. With prior Sterrad generation models, it received an“excellent” compatibility rating after 500 cycles.
• MED-353ND is generally regarded for resisting few cycles of ETO and gamma radiation.
• MED-353ND can survive more than 360 cycles of liquid disinfection based on glutaraldehyde (3.4% concentration) and peracetic acid (0.23%concentration before significant deterioration of the glue joint.

®

®

Packaging Availability• EPO-TEK® MED-353ND is available in specialty packaging such as Pre-Mixed Frozen Syringes (PMF), Bi-Paks, or bulk (A & B containers).
• A Bi-Pak video tutorial can be found here:
http://www.epotek.com/site/technical-material/application-video-tutorials/117-effective-handling-and-mixing-of-epo-tek®-bi-packs.html• A video tutorial on handling frozen syringes can be found here:
http://www.epotek.com/site/technical-material/application-video-tutorials/231-proper-receiving-and-thawing.html

Med i ca l GradeEpoxy Technology Inc.

E P O - T E K®
Sterrad® is a registered trademark of J & J Company.
EPO-M353ND-02

14 Fortune Drive • Billerica, MA 01821
phone 978-667-3805 fax 978-663-9782
med@epotek.com© Epoxy Technology Inc. 2018