ESOP̲PAMPH-E-191114-VER005

SimpleMedicine
Dispensing

The recommendation of the Consumer Agency accident investigation...

New product packaging should be investigatedin order to prevent future accidents

Minister of Health, Labour and Welfare Mr. Shiozaki
conference after the Cabinet meeting (12.22.2015)

Press

Tablet packaging
revolution

At the press conference on December 22, 2015, there was a question and answer
session. The Ministry of Health, Labor and Welfare said that they are currently
investigating measures to prevent accidental poisoning incidents, such as
requiring child resistant packaging. Awareness of the widespread problem will
also be raised through local governments and the healthcare system.

A
Coverage in the media:
MEDIS
NEW "Recently developed ESOP can replace PTP."
1. NIHON KEIZAI NEWS2. SANKEI NEWS3. The HOSO TIMES
4. The Chemical Daily
5. The HOSO TIMES
6. NIHON KEIZAI NEWS7. SANKEI NEWS8. The NIKKAN KOGYO NEWS
9. NIHON KEIZAI NEWS10. NIKKEI SANGYO NEWS11. The HOSO TIMES
12. The NIKKAN KOGYO NEWS13. NIHON KEIZAI NEWS14. YAKUJI NIPPO

11.25.2015
11.18.2015
11.17.2015
10.13.2015
10.12.2015
08.24.2015
07.03.2015
06.11.2015
02.23.2015
01.22.2015
12.08.2014
10.09.2014
04.28.2014
04.18.2014

New Design to Replace Press-Through-Pack (PTP)

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2 Steps①Open

PATENTEDPRODUCT②SlideMorimoto Pharma is looking for partners
for future ESOP projects
Morimoto Pharma has completed the launch of the next generation soft tablet
packaging, ESOP. We are committed to creating combination products withpharmaceutical industry partners and medical care professionals. If you areinterested in potential collaborations/innovative uses regarding ESOP, pleasecontact us via the information provided below.

http://www.morimoto-iyaku.jp/english-top
Please visit us on the web for more information.

MORIMOTO-PHARMA CO., LTD. http://www.morimoto-iyaku.jp/english-top

5-8-28 Mitejima, Nishi-yodogawa-ku, Osaka 555-0012, JAPAN
Tel: +81-6-6476-5473 Fax: +81-6-6476-5573 E-mail: customer@m-ph.co.jp

Novel Soft Tablet
Packaging

ESOP
Easy Seal Open Pack

ESOP is a new soft packaging for tablets to replace Press-Through-Packs (PTP), also known asblister packs. ESOP is made using MORIMOTO's patented technology which allows creationof soft and transparent packaging with "easy open seals". The innovative soft design is safeto the gastrointestinal tract in the case of accidental ingestion.

MORIMOTO - PHARMA CO., LTD.

Our goal is zero medical incidents from accidental ingestion!
Accidental ingestion of tablet packaging is a major concern for seniors,
while accidental poisoning from medication is a concern for children.
Accidental ingestion/ Drug mistakes / Leftover medicine...
ESOP has been developed to combat these problems.
ESOP is a novel tablet packaging to solve common
problems with Press-Through-Packs (also known asblister packs). It is made using our easy open sealtechnology. Because it is a soft ﬁlm, it will not cause
harm to the gastrointestinal tract if accidently
swallowed. The design is also child resistant so it canalso help to eliminate the accidently poisoning ofchildren who get into medication.

Soft ﬁlm

Perforation

Seal Packaging

Medicine Information

Accidental
ingestion

・Harm from accidental ingestion of
packaging by seniors.
(26 published cases in just two years)
・Accidental poisonings of children.

(Over 5,000 incidents per year)

Drug
mistakes■Comparison of ESOP and Press-Through-Packaging(PTP)
PTP

ESOP

Can lead to dispensing
errors

Accurate Dispensing via
Barcode Conﬁrmation

Expiration of Medicine
once box is opened

3~6 months

3 years

Checking Medication
Expiration Dates

Expiration date not listed,diﬃcult to conﬁrm

Expiration date on label
and also part of barcode

Harm from Accidental
Ingestion, Poisonings

Serious issue

Soft packaging harmlessly
passes through body, childresistant design

Not designed for individual
dispensing

Perforated to makeindividual dispensing easy

Mass Disposal, Dispensing
Large Quantities (Automated)

Has been sucessfully
automated

Automation is easy

Mass Disposal, Dispensing
Large Quantities (By Hand)

Time consuming. Can leadto repetitive strain injuries.

Quickly done with scissors.

Dispensing Errors

Individual Pack
Dispensing■ESOP -Automatic Medicine Vending-

Leftovermedicine

・Medicine Dispensing Errors(1,300 cases per year)①Add ESOP box to correct
position on shelf.

Automatic Medicine
Vending Machine

ESOP rolls can be used for automatic vending.
※Even with normal shelﬁng, ESOP still can be used to increase the speed of dispensing.
It can be used alongside PTP packaging.
ESOP roll size can be selected basedon demand and available space.

・50 billion yen per year wasted in Japan alone.

barcodeCan be intermixed into existing setups.
Roll type large

PTP trayemptiedES

MethodComparison of medicine envelopes(Top:ESOP Bottom:PTP)

ESOP and PTP

OP
ESRoll type small
ES

OP

ES

OP

ES

OP

ES

OP

OP

ES

OP

Sheet type

②ESOP packs will be automaticallydispensed.

Open ﬂap(Back side)

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Folded State

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Opened state(

Eliminates cuts to hands due
to sharp corners. No risk ofgastrointestinal tract injuries
if accidently swallowed.

◆ ESOP's 4 key strengths:on

Can easily be opened
using one hand. Usableby persons with limited
hand mobility/strength.
When unfolded drug
information can easily
be read. When folded it
is extremely compact.

ESOP Summary

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long label(Front side)OP

Remove from box
and place on shelf③Multiple medications for the same patientare dispensed into a single tray.

short label(Front side)ES

Each individual pack ismarked with expiration
date. Has barcode for quick
identiﬁcation.
Airtight design prevents
drug degration due to air
and moisture.

①Convenience ②Identification ③Portability ④Airtight Design◆ Effective at preventing accidental ingestion of packaging by seniors andaccidental poisoning of children.
◆ Dispensing of medication is simple and speedy.
◆ Helps prevent dispensing errors & leftover medicine. Also allows for
identification of individually dispensed packs.
※Development package(sample)

Child resistant design preventsaccidently poisonings.
Sheet type 70pcs

Sheet type 140pcs

Roll type 200pcs

Roll type 500pcs※Photos are for reference only. Design, color and size may have changed.