Scientific Program
Main Hall

Room A

Room B-1

Room D

Room E

Open Lectures for General Public (inJapanese)

Short Course"Fundamentals of Mass
Spectrometry"(Two-day course)"Fragmentation Methods, Their
Fundamentals and Application inProteomics"(One-day course)"Introduction to Imaging Mass
Spectrometry"(One-day course)
Short Course"Fundamentals of Mass
Spectrometry"(Two-day course)

15 (Sat)

16 (Sun)Tutorial Lectures (Plenary)Nico M. M. Nibbering
Michael L. Gross
Opening Plenary Lecture
Hiroyuki Hamada
Plenary LectureDavid E. Clemmer

17 (Mon) Morning

17 (Mon) Afternoon

Session 1:
Developments in Tandem Mass
Spectrometry - Hybrid
Instrumentation"The whole is greater than the sumof its parts" (Aristotle).
Chair: Morio Ishihara
Keynote: Alexander A. Makarov

Session 2:
Advances in Methods and MS
Instrumentation for Biomolecule
Characterization
Chair: Vicki H. Wysocki
Keynote: Andrea Sinz

Session �:
Structures and Dynamics of Atomic
and Molecular Clusters
Chair: Fuminori Misaizu
Keynote: Knut R. Asmis

Session �:
Imaging I
Chair: Mitsutoshi Setou
Keynote: Ron Heeren

Session 5:
Advances in Spray Ionization Techni�ues
Chair: Charles N McEwen
Keynote: Kentaro Yamaguchi

Session 6:
Novel Approaches in Proteomics
Analysis
Chair: Roman Zubarev
Keynote: Joshua J. Coon

Session 7:
New Ionization Methods and Related
Topics for the Next Generation
Chair: Kenzo Hiraoka
Keynote: Robert Cody

Session 8:
Collision Dynamics and Spectroscopy
�sing Ion Storage Rings and Traps
Chair: Haruo Shiromaru
Keynote: Steen Brøndsted Nielsen

Session 9:
Imaging II
Chair: Jiro Matsuo
Keynote: Nick Winograd

Session 10:
Ion Mobility Spectroscopy Based on
Instrument � Theoretical Development
Chair: Toshiki Sugai
Keynote: Alexandre A. Shvartsburg

Session 11:
Glycomics: From Disease Markers to
Therapeutic Antibody Products
Chair: Hyun joo An
Keynote: Carlito Lebrilla

Session 12:
On-site Mass Spectrometry Miniaturized Instruments and Allied
TechnologiesChair: Shuichi Shimma
Keynote: Zoltán Takáts

Session 1�:Accelerator Mass Spectrometry
Chair: Hiroyuki Matsuzaki
Keynote: Peter Steier

Session 1�:Ion-surface Collisions: Collisioninduced Dissociation and SoftLanding
Chair: Jean Futrell
Keynote: Julia Laskin

Session 15:
Mass Spectrometry for Nuclear Applications
and Safety
Chair: Nobuo Takaoka
Keynote: Yongzhong Ouyang

Session 16:
Glycoanalytical Technology for
Systems Glycobiology and Functional
Glycomics
Chair: Jane Thomas-Oates
Keynote: Pauline M. Rudd

Session 17:
Non-Covalent Ion�MoleculeInteractions
Chair: Seung-Koo Shin
Keynote: Peter B. Armentrout

Session 18:
Advances in Resolution and Accuracyof Isotope Ratio Analyses
Chair: Takafumi Hirata
Invited: Jochen Vogl

Session 19:
Mass Spectrometric Diagnosis
Chair: Toyofumi Nakanishi
Keynote: Renato Zenobi

Session 20:
The Ion formation and Dissociation
Mechanisms in MALDI
Chair: Myung Soo Kim
Keynote: Richard Knochenmuss

Session 21:
Platform Technology for
Metabolomics
Chair: Yoshiya Oda
K
Keynote:
A
Annie
i E
Evans

Session 22:
Instrumentation Developments in
Mass Spectrometric Imaging
Chair: Anastassios Giannakopulos
K
Keynote: B
Bernhard
h dS
SpenglerlSession 2�:Gas Phase Fragmentation
Mechanisms of Biomolecular Radicals
Chair: Shigeo Hayakawa
K
Keynote: Ri
Richardh d A.J.
A J O'Hair
O'H i

Session 2�:Regulated Bioanalysis
Chair: Shinobu Kudoh
Keynote: Tatsuo Kurokawa

Session 25:
New Approaches to Defining the Diversity of
Glycans
Chair: Catherine E. CostelloK
Key: J
Jane Th
Thomas-Oates
O

Session 26:
Lipidomics : Recent New Techni�ues
and Applications
Chair: Stephen Blanksbｙ
Keynote: Gavin E. Reid

Session 27:
Progress in Microbiology
Chair: Catherine Fenselau
Keynote: Jeremy K. Nicholson

Session 28:
IR Spectroscopy of Gas-phase Ions
Chair: Dietmar Kuck
Keynote: Philippe Maître

Session 29:
The Advances in Biological Mass
Spectrometry in Drug Discovery andDevelopment: Current State of the
Art and Challenges
Chair: Ajai Chaudhary
Keynote: Ragu Ramanathan

Session �0:
Data Processing and Informatics for SIMS
Chair: DaeWon Moon
Keynote: David Castner

Session �1:
Native Mass Spectrometry and
Structural Biology
Chair: Satoko Akashi
Keynote: Joseph A. Loo

Session �2:
Formation and Dissociation of
Peptide Radical Ions
Chair: Dominic T.W. Chan
Keynote: Roman A. Zubarev

Session ��:
JMS Award Symposium
Chair: Chair: Richard M. Caprioli(Editor-in-Chief, JMS)

Session ��:
MS Informatics for Identification andCharacterization
Chair: Shigeki Kajihara
Keynote: David Fenyö

Session �5:
Environment I
Chair: Peter Haglund
Keynote: Terry Bidleman

Session �6:
Advances in Ion Mobility Mass
Spectrometry
Chair: Joseph A Loo
Keynote: Michael T. Bowers

Session �7:
Challenges in High Resolution andHigh Accuracy Mass Measurement
Mass Spectrometry
Chair: Evgeny Nikolaev
Keynote: Alan G. MarshallSession �8:Mass Spectrometry for Metabolic
Diseases
Chair: Makoto Yoshino, Seiji Yamaguchi

Session �9:
MS Informatics for �uantitation
Chair: David Fenyö
Keynote: Jürgen Cox

Session �0:
Environment II
Chair: Takeshi Nakano
Keynote: Peter Haglund

Session �2:
New Developments in Instruments
and Detectors
Chair: Takaya Sato
Keynote: Evgeny N. Nikolaev

Session ��:
Novel Proteomics Methodologies
Chair: Yasushi Ishihama
Keynote: Michael J. MacCoss

Session ��:
Ambient Ionization
Chair: Jentaie Shiea
Keynote: Kenzo Hiraoka

Session �5:
Cell Biology / Cellular Pathways
Chair: Renato Zenobi
Keynote: Tsutomu Masujima

Life Sciences

Medical Sciences

Fundamentals

Isotope Ratio MS

Instrumentation

Ionization

Environment / Microorganism

Poster Session

Plenary Lecture
Albert J. R. Heck

18 (Tue) Morning

18 (Tue) Afternoon

Poster Session

Award Ceremony
Curt Brunn�e Award Lecture

19 (Wed) Morning

Poster Session

19 (Wed) Afternoon

Plenary Lecture
Hisayoshi Yurimoto

20 (Thu) Morning

20 (Thu) Afternoon

Thomson Medal Award Lectures
Plenary Lecture
Richard M. Caprioli

21 (Fri) Morning

21 (Fri) Afternoon

Session �1:
Chemistries of Trapped Ions and their
Applications to Biological Mass
Spectrometry
Chair: Gavin E. Reid
Keynote: Scott A. McLuckey
Closing Plenary Lecture
R. Graham Cooks

Poster Session

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List of Oral Sessions[Monday Morning, 17th September (9:00-11:00)]
Session 1 (Main Hall):Developments in Tandem Mass Spectrometry - Hybrid
Instrumentation "The whole is greater than the sum of its
parts" (Aristotle).
Chair: Morio Ishihara
Keynote: Alexander A. Makarov“Orbitrap-based hybrid mass spectrometers: synergy ofanalyzers”
Scope of Session: Hybrid mass spectrometers are designed to combine
the best features of different mass analyzers in order to obtain highly desirable performance characteristics and unique analytical functions thatare not attainable with non-hybrid systems. The type and quality of data
depends greatly on the physical characteristics of individual devices implemented on each stage. This sessions aims to present instrumental
developments in tandem hybrid mass spectrometry spanning application
areas from inorganic chemistry to identification of large molecules andthe study of molecular complexes, and to foresee the future of this typeof instruments.
Keywords: Hybrid instrumentation, Tandem mass spectrometry, Instrumental development

Session 2 (Room A):

Advances in Methods and MS Instrumentation for
Biomolecule Characterization
Chair: Vicki H. Wysocki
Keynote: Andrea Sinz

“Chemical Cross-Linking and Mass Spectrometry:
A Fruitful Combination for Protein 3D-Structure Analysis”

Scope of Session: New methods and instrumentation have advanced thestructural characterization of large biomolecules and complexes. Thissession focuses on newer methodologies that have enabled the characterization of the primary and higher order structure of biomolecules, including newer forms of dissociation techniques, ioni-zation methods, labeling strategies, and crosslinking.
Keywords: ETD, SID, Crosslinking, H/D exchange, Chemical modification,
Ambient ionization techniques

Session 3 (Room B-1):

Structures and Dynamics of Atomic and Molecular Clusters
Chair: Fuminori Misaizu
3

Keynote: Knut R. Asmis“Recent Advances in the Vibrational Spectroscopyof Mass-Selected Gas Phase Cluster Ions”
Scope of Session: Size-dependent physical and chemical properties ofgas-phase clusters have been investigated using various experimental
techniques coupled with mass spectroscopy. The purpose of this session
is to discuss recent progress in the field of structures and chemical reaction dynamics of clusters.
Keywords: Clusters, Spectroscopy, Electronic state, Geometrical structure, Reaction dynamics* The titles of keynote lecture may be subject to change in the final program.

Session 4 (Room D):
Imaging-I
Chair:
Mitsutoshi Setou
Keynote: Ron M Heeren“Imaging molecular signals with multimodal imaging
mass spectrometry”

Scope of Session: Mass imaging technique is powerful tool to reveal
molecular distribution in cells and tissues. There is still strong need forhigh spatial resolution and high sensitivity beyond the state-of-art. Whenthe technology is pursued towards the limits of resolution, low abundance
analytes and/or the need to sample species over a large dynamic range,
issues arise that can be ignored in normal operation.
Keywords: Imaging Mass Spectrometry, Cells, Tissues, SIMS

Session 5 (Room E):

Advances in Spray Ionization Techniques
Chair:Charles N McEwen
Keynote: Kentaro Yamaguchi“Cold-Spray Ionization Mass Spectrometry”

Scope of Session: Spray ionization has proven to offer the softest means
to preserve noncovalent interactions in the gas phase including those oflabile supermolecules; recently ambient ionization methods such as DESI
have evolved for direct spray ionization of surfaces.
Keywords: Electrospray, Sonic spray, Non-covalent interactions, DESI

[Monday Afternoon, 17th September (15:00-17:00)]
Session 6 (Main Hall):

Session 9 ( (Room D):

Keynote: Joshua J. Coon

Keynote: Nicholas Winograd

Novel Approaches in Proteomics Analysis
Chair:
Roman Zubarev“Instant Spectral Assignment for Rapid, High-Throughput
Targeted Proteomics”

Scope of Session: Proteomics, after 15 years of explosive development,
faces unexpected challenges from the next-generation sequencing
methods in other omics areas. What breakthroughs can address thesechallenges and advance proteomics beyond the state-of-the-art?
Keywords: De novo sequencing, Novel fragmentation techniques, Novelquantification technique

Session 7 (Room A):

New Ionization Methods and Related Topics for the Next
Generation
Chair:
Kenzo Hiraoka
Keynote: Robert B Cody
“What is the Opposite of Pandora's Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources.”
Scope of Session: Ionization plays a crucial role for mass spectrometry.
This session focuses on the new ionization methods for the
next-generation mass spectrometry. Ionization may be taken place undervacuum or ambient conditions.
Keywords: Ionization, Charge Transfer, SNMS, Shockwave,
Tribo-Phenomenon

Session 8 (Room B-1):

Collision Dynamics and Spectroscopy Using Ion Storage
Rings and Traps
Chair:
Haruo Shiromaru
Keynote: Steen Brøndsted Nielsen“Spectroscopy of firefly luciferin and oxyluciferin anions invacuo. Color tuning by a micro-environment?”
Scope of Session: This session covers the recent drastic development ofelectrostatic devices, i.e. ion storage rings and ion traps. Various aspects
including lifetime measurements of metastable states, action spectroscopy by laser irradiation, cross section measurements for low-energy
electron collisions, and their application to bio-molecular ions will betreated. Comparison between an ion storage ring and an ion trap withkeV energies as well as the traditional RF ion trap focusing on their advantages will be also discussed.
Keywords: Electrostatic ion storage ring, Ion trap, Metastable states,
Laser-induced action spectroscopy, Low-energy electron collision* The titles of keynote lecture may be subject to change in the final program.

Imaging-II
Chair:Jiro Matsuo“Nanoscale Chemical Imaging of Biomaterials
with Cluster SIMS”
Scope of Session: Mass imaging technique is powerful tool to reveal
molecular distribution in cells and tissues. There is still strong need forhigh spatial resolution and high sensitivity beyond the state-of-art. Whenthe technology is pursued towards the limits of resolution, low abundance
analytes and/or the need to sample species over a large dynamic range,
issues arise that can be ignored in normal operation.
Keywords: Imaging Mass Spectrometry, Cells, Tissues, SIMS

Session 10 (Room E):

Ion Mobility Spectroscopy Based on Instrument & Theoretical Development
Chair:
Toshiki Sugai
Keynote: Alexandre A. Shvartsburg“Pushing the frontier of high-definition ion mobility spectrometry
using FAIMS”
Scope of Session: Ion mobility spectrometry (IMS) is established as a
powerful tool to characterize the 3-D structure of biomolecules andnanomaterials, and new theoretical results and instrumental methods
point to a yet greater potential for the IMS approach. This session focuses on recent developments in nonlinear IMS or FAIMS employing
strong electric fields, improved understanding of the IMS fundamentals,
and novel instrumentation, which would provide the foundation fornext-generation IMS technology.
Keywords: Ion mobility Spectrometry, High-resolution Differential IMS,
New instrumentation, Theoretical analyses, Applications to bio & nanorelated molecules and materials

List of Oral Sessions[Tuesday Morning, 18th September (9:00-11:00)]
Session 11 (Main Hall):

Session 14 (Room D):

Glycomics: From Disease Markers to Therapeutic Antibody
Products
Chair:
Hyun joo An

Ion-surface Collisions: Collision-induced Dissociation andSoft Landing
Chair:
Jean Futrell

Keynote: Carlito Lebrilla

Keynote: Julia Laskin“Is high throughput glycomics possible?”
Scope of Session: This session will cover new approaches for biomarker
discovery and biopharmaceutical glycosylation profiling using mass
spectrometry-based glycomics and glycoproteomics.
Keywords: Glycomics, Glycoproteomics, Glycobiomarker, Therapeutic
antibody, Glycosylation

Session 12 (Room A):

On-site Mass Spectrometry -Miniaturized Instruments andAllied TechnologiesChair: Shuichi Shimma
Keynote: Zoltan Takats“In-vivo, Real-time Identification of Tissues in Human Surgical
Environment by Rapid Evaporative Ionization Mass
Spectrometry”
Scope of Session: This session covers the topic of promising instruments(ion traps, quadrupole mass filters, time-of-flight instruments, etc.) andrelated techniques to realize on-site mass spectrometry. In recent years,
design and development of miniature mass spectrometers has been at
the forefront of research in mass spectrometry. These instruments havewidespread applications, for example, detection and identification ofchemical and biological hazards for homeland security, environmental
monitoring, food safety, and so forth. The miniature mass spectrometers
are capable of on-site analysis of these applications. It is considered thatminiature instruments would be more commonly utilized in the future.
Therefore, this session will become a good opportunity to share theknowledge of the present situation and future prospects.
Keywords: Miniaturized/portable mass spectrometers, On-site detection
and monitoring, On-site sampling and preparation

Session 13 (Room B-1):

Accelerator Mass Spectrometry
Chair:
Hiroyuki Matsuzaki
Keynote: Peter Steier“Accelerator Mass Spectrometry - analysis of the rarest atom
species for earth and environmental science”
Scope of Session: Acelerator Mass Spectrometry (AMS) is an uniquemethod for detection of several special rare isotopes such as 10Be, 14C,
26
Al, 36Cl, 129I and 236U, so on. Using these isotopes, new frontier isopened in many scientific fields including Earth environmental science.
This session will summarize frontier applications of AMS in various fields
and anticipate future prospects.
Keywords: Accelerator mass spectrometry, Cosmogenic radio nuclides,
Anthropogenic nuclides, Radiocarbon dating, Isotope system, Beryllium-10, Iodine-129, Alluminum-26, Chroline-36, Carbon-14* The titles of keynote lecture may be subject to change in the final program.

“Ion-Surface Collisions in Mass Spectrometry: Activation,
Dissociation and Soft-Landing”
Scope of Session: During the past decade key theoretical and experimental studies of the kinetics of ion-surface collision phenomena haveestablished a fundamental understanding of the principal mechanisms
involved in both collision-induced dissociation and soft landing. Notably,moderate energy ion collisions on self-assembled monolayer surfaces
are one of the most promising techniques for sequence determination forlarge peptides and protein complexes. Equivalent advances in the understanding of the time evolution of charge states and structures following
low energy capture of ions on surfaces provide the basis for utilizing mass
selected complex ions to create spatially dispersed functional devices.
Several examples and instrumental advances enabling them will be described.
Keywords: Soft landing, Collision-induced dissociation, Ion-surface collision phenomena

Session 15 (Room E):

Mass Spectrometry for Nuclear Applications and Safety
Chair:
Nobuo Takaoka
Keynote: Huanwen Chen
“Extractive Electrospray Ionization Mass Spectrometry for
Uranium Chemistry Studies”
Scope of Session: Nuclear energy has paid an important role in global
energy supplies. However, the Great East Japan Earthquake and Tsunami has led to the accident at the Fukushima Daiichi Nuclear Power
Plant, which has resulted in a significant question on nuclear energy development. The nuclear safety becomes an essential element for nuclear
energy application. At the IAEA General Conference in September 2011,
the IAEA Board of Governors approved and endorsed IAEA's /Nuclear
Safety Action Plan/ by all 151 Member States, which is to strengthen the
global nuclear safety framework. Mass spectrometry is powerful tool forboth nuclear energy development and nuclear safety. The scientists andtechnicians who work at mass spectrometry society may contribute theirefforts to fellow up the nuclear applications and safety. The 19th IMSC
will set a session to discuss the issue. The following subjects are encouraged:
1. ICP-MS, SIMS, GD-MS and other MS technologies applied to nuclear
fuel and materials, water chemistry at nuclear power plant, environmental
monitoring near NPP sites, global falls, sea water, sediments, remediation, etc.
2.Mass spectrometries including organic & biological MS applied to theeffects of nuclide and adiation on human beings and biosphere.
3.New technology of mass spectrometry for nuclear applications andsafety.
Keywords: Nuclear energy development, Nuclear safety

[Tuesday Afternoon, 18th September (15:00-17:00)]
Session 16 (Main Hall):Glycoanalytical Technology for Systems Glycobiology andFunctional Glycomics
Chair:
Jane Thomas-Oates
Keynote: Pauline M. Rudd
“Glycoanalytical technologies for systems glycobiology,
biomakrer discovery & therapies”
Scope of Session: The development of glycoanalytical technologies havegreatly enhanced the study of glycobiology, facilitating the discovery of
disease-related solutions and providing an informative view of glycosylation and its relationship with other biological disciplines in a systems biology approach. Technologies for rapid and reliable identification of glycan structure as well as the advances of computer software and glyco
database are discussed.

Continuous developments in inorganic mass spectrometry techniques
have revolutionized the precision of the isotopic ratio measurements.
Applications of the inorganic mass spectrometry in metrology or biochemistry are beginning to appear over the horizon. This session aims topresent the instrumental developments for precise and accurate isotope
ratio measurements and also to discuss the future direction of the techniques.
Keywords: Isotope ratio analysis, Inorganic mass spectrometry, Absoluteanalysis, Metrology, Imaging mass spectrometry, Mass bias, In-situ isotopic analysis, External correction

Session 19 (Room D):

Mass Spectrometric Diagnosis
Chair:
Toyofumi Nakanishi

Keywords: Glycobiology, Glycotechnology, Structural analysis, Bioinformatics, Database, Data management, Automated annotation

Keynote: Renato Zenobi

Session 17 (Room A):

Scope of Session: Mass spectrometry will soon take over the current diagnostic detection system to change the system to be versatile, sensitive,
quantitative and qualitative. The potential of mass spectrometry for diagnosis will be discussed with basic and clinical validations.

Non-Covalent Ion–Molecule Interactions
Chair: Seung-Koo Shin
Keynote: Peter B. Armentrout“The Thermochemistry of Non-Covalent Ion-Molecule”
Scope of Session: Non-covalent ion–molecule interactions are the building principle underlying the gathering of ions and molecules beyond thequantum mechanical description of chemical bonds. They are the driving
forces behind the solvation of ions, molecular recognition of ionic species,
assembly of host–guest ionic complexes, formation of metal ion–ligand
complexes, and folding of DNAs and proteins in ionic environments. Thissession invites the presentation of ion–molecule chemistry that deals with
spectroscopy, structures, energetics, conformation, and reactions. Bothexperimental and theoretical works are welcome to the session. Professor Peter B. Armentrout at the University of Utah will deliver a keynote
speech at this session.
Keywords: Noncovalent ion-molecule interactions, Molecular recognition,
Collision-induced dissociation, Host-guest complexes. Ion-mobility.

Session 18 (Room B-1):

Advances in Resolution and Accuracy of Isotope Ratio
Analyses
Chair:
Takafumi Hirata
Keynote: Jochen Vogl
“Advances in Isotope Ratio Mass Spectrometry andRequired Isotope Reference Materials”
Scope of Session: The magnitude of many analytical problems is clearly
exacerbated when trying to obtain the levels of precision required for themeaningful interpretation of isotope ratios, and this section of the analytical community is actively solving problems such as spectral interference
and mass discrimination drift at new levels of sensitivity and precision.

* The titles of keynote lecture may be subject to change in the final program.

“Ambient Mass Spectrometry for Detecting Biomarkers
in Breath”

Keywords: Disease-related biomarker, Clinical medicine, New diagnostic
technology

Session 20 (Room E):

The Ion formation and Dissociation Mechanisms in MALDI
Chair: Myung Soo Kim
Keynote: Richard Knochenmuss“MALDI and Related Desorption / Ablation / Ionization
Methods:A Solved Problem or Still a Mystery?”
Scope of Session: The session will deal with two fundamental subjects inthe matrix-assisted laser desorption ionization (MALDI). The first subject
is the mechanism for the gas-phase ion formation from a solid sample, i.e.
a matrix-analyte mixture. The second subject is the mechanism for the
dissociation of polyatomic ions such as protonated peptides generated by
MALDI. The session will be a forum for the fundamental aspects of theprocesses rather than for the detailed mechanistic pathways for individual
ions. Not only the presentations of experimental results but also those oftheoretical and computational results will be accommodated.
Keywords: Fundamentals of MALDI, Gas-phase ion formation mechanism, Ion dissociation mechanism.

List of Oral Sessions[Wednesday Morning, 19th September (9:00-11:00)]
Session 21 (Main Hall):

Session 24 (Room D):

Platform Technology for Metabolomics
Chair:
Yoshiya Oda

Regulated Bioanalysis
Chair:
Shinobu Kudoh

Keynote: Annie Evans

Keynote: Tatsuo Kurokawa“New generation high-field Orbitrap instrumentation in
untargeted metabolic profiling”
Scope of Session: Discussion of a metabolomics global profiling technology utilizing high-throughput dual column UPLC/MS/MS2 and GC/MS
analytical methods for the analysis of complex biological samples.
Keywords: Metabolomics, UPLC/MS, GC/MS, Sample preparation

Session 22 (Room A):

Instrumentation Developments in Mass Spectrometric Imaging
Chair:
Anastassios Giannakopulos
Keynote: Bernhard Spengler“High Resolution in Mass and Space: New Developments andTrends in MALDI Mass Spectrometry Imaging”
Scope of Session: Mass spectrometric imaging (MSI) links the universal
detection capability of mass spectrometry with the ability to record thespatial distributions of a wide range of atoms and molecules. MSI has
penetrated almost all areas of analytical science and has found uses fromdetecting elements in industrial applications to determining drug and biological molecule distributions in tissue. Ever increasing demand for highspatial and mass resolution is driving development in analytical instrumentation. This session aims to present recent instrumentation developments in mass spectrometric imaging with emphasis on high resolution
spatial and mass spectrometric characteristics.
Keywords: Imaging mass spectrometry, Instrumental development

Session 23 (Room B-1):

Gas Phase Fragmentation Mechanisms of Biomolecular
Radicals
Chair: Shigeo Hayakawa
Keynote: Richard A.J. O'Hair“Gas Phase Chemistry of Biomolecular Radicals –An Overview”
Scope of Session: Fragmentation mechanisms of gas phasebiomolecular ions have been investigated using tandem mass spectrometry with a range of excitation methods including CID, ETD, ECD, andphoto-excitation. Through a combination of experiments and theoretical
calculations on model systems, it has been found that radicals can play a
critical role in inducing fragmentation. This session covers the fragmentation mechanism of radicals formed by various excitation methods.
Keywords: Gas phase ion chemistry, Hydrogen atom transfer, Gas phasefragmentation, Radical ion reaction, Fundamental interest, Collision induced dissociation, Electron capture or electron transfer reaction, Electron collision, Electronic excitation, Photo excitation, Electron induced
dissociation* The titles of keynote lecture may be subject to change in the final program.

“Drug regulation and bio-analysis”
Scope of Session: Over the last 20 years, bioanalysis in drug researchand development has received benefits of selectivity and sensitivity
achievable by mass spectrometry (MS) in conjunction with chromatographic techniques. There are, though difficulties and problematic issues
needed to be overcome or to be cared for proper results, which mostly
become apparent in liquid chromatographic approaches with MS. To obtain proper results, analyses have to be conducted correctly under necessary regulations or guidelines that must be fair and scientifically correct,
and are preferably acceptable globally as internationally harmonized
ones in future. This session covers the recent development in regulations
and guidelines, which are not exclusive for LC-MS but also for ligand
binding assays. Its related topics with new ideas and practical implementations for better MS-based bioanalysis and future prospect are also
discussed.
Keywords: Regulation, Guideline, EMA, FDA, PMDA, MHLW, Mass
spectrometry, Chromatography, Quantitation, Qualitative analysis,
Bioanalysis

Session 25 (Room E):

New Approaches to Defining the Diversity of Glycans
Chair:Catherine E. Costello
Keynote: Jane Thomas-Oates“Development and Application of a Rapid and Sensitive Method
for Screening Cellular Models of Congenital Disorders of
Glycosylation”
Scope of Session: Carbohydrates and glycoconjugates are widely dispersed in nature; the importance of their roles and their broad and continuously changing structural heterogeneity are now coming to be much
more appreciated in the community, yet the tools for their characterization
require substantial further development. To fully determine and profile thetypes and distributions of glycan structures, both in the human populationand throughout nature, researchers worldwide are generating novel
methodologies and significant modifications of the mass spectrometry-based techniques and bioinformatics tools that facilitate peptide andprotein analysis. This session will highly the dynamic research and new
applications in mass spectrometry for glycobiology.
Keywords: Glycans, Glycoconjugates, Glycolipids, Glycoproteins,
Glycopeptides, Ion mobility spectrometry

[Wednesday Afternoon, 19th September (15:00-17:00)]
Session 26 (Main Hall):

Lipidomics : Recent New Techniques and Applications
Chair: Stephen Blanksby
Keynote: Gavin E. Reid
“High-Resolution 'Shotgun' Mass Spectrometry andChemical Labeling for Comprehensive and Quantitative
Lipidome Profiling of Disease”
Scope of Session: Recent advances in lipidomics have given rise to advanced methods for precise structure elucidation of molecular lipids aswell as mapping their distribution within biological tissue. The structure
and location of lipids have proved to be tightly connected to physiological
function of specific tissues. In particular, recent advances in mass spectrometry such as ozone-induced dissociation, covalent adduct chemical
ionization and high energy collision induced dissociation now allow the
precise positions of carbon-carbon double bonds (and other subtle
structural features such as sn-position) to be assigned online even withincomplex lipids. Advances in mass spectrometric methods for lipidomics
and their applications will be discussed.
Keywords: Phospholipids, Molecular species, Double bond localization

Session 27 (Room A):
Progress in Microbiology
Chair:Catherine Fenselau

Keynote: Jeremy K. Nicholson“Translating metabolic phenotyping and systems medicine into
clinical Practise: Understanding gut microbial-host Interactions
in personalized public healthcare problems”
Scope of Session: Reports in this session will be presented on applications of mass spectrometry to new areas of research in microbiology, andon new instrumental and chemical methods for mass spectrometry-based
analysis of bacteria and viruses.
Keywords: Bacteria, Virus, Identification, Metabolome, Host-microbiome
interaction

Session 28 (Room B-1):

IR Spectroscopy of Gas-phase Ions
Chair:
Dietmar Kuck
Keynote: Philippe Maître
“IR Photodissociation Spectroscopy: A new dimension to
Tandem Mass Spectrometry”
Scope of Session: This session would cover the exciting new field of IR
spectroscopy of cold and room temperature ions with emphasis on thecurrently hotly debated structural issues on peptide fragments.
Keywords: Ion spectroscopy, Infrared lasers, Fragment structures, Modeling, Peptides vibrational spectra, Specific ion activation, Fragmentation
modeling* The titles of keynote lecture may be subject to change in the final program.

Session 29 (Room D):

The Advances in Biological Mass Spectrometry in Drug
Discovery and Development: Current State of the Art andChallenges
Chair:
Ajai Chaudhary
Keynote: Ragu Ramanathan“Advances in the Application of Mass Spectrometry to Drug
Metabolism and Pharmacokinetics Studies”
Scope of Session: The session will focus on recent advances, applications, and challenges in the field of mass spectrometry in pharmaceutical
drug discovery and development.
Keywords: Pharmacokinetics, Pharmacodynamics, Drug development,
Drug discovery, Metabolite, Quantification

Session 30 (Room E):

Data Processing and Informatics for SIMS
Chair:
DaeWon Moon
Keynote: David G Castner“Image and Spectral Processing for ToF-SIMS Analysis of
Biological Materials”
Scope of Session: Thanks to application of chemometrics to intricate
SIMS data, information from SIMS has been expanded. For instance,
subtle changes in molecular structures and distributions of biomoleculesin tissues can be obtained with SIMS. In this session, brand-new SIMS
studies in terms of data processing and informatics will be discussed.
Keywords: Chemometrics, Multivariate analysis, Data processing,Informatics, G-SIMS, Database

List of Oral Sessions[Thursday Morning, 20th September (9:00-11:00)]
Session 31 (Main Hall):

Session 34 (Room D):

Native Mass Spectrometry and Structural Biology
Chair: Satoko Akashi

MS Informatics for Identification and Characterization
Chair:
Shigeki Kajihara

Keynote: Joseph A. Loo

Keynote: David Fenyö“Integrating Native Mass Spectrometry and Top-Down MS for
Defining Protein Interactions Important in Biology and Medicine”“The value of different types of information in MS based
identification”

Scope of Session: The analysis of noncovalent protein complexes bymass spectrometry has advanced to the study of protein-ligand and protein-protein complexes and as large as the MDa range. In this session,
the structural characterization of protein complexes of importance to biology will be discussed.

Scope of Session: This session will cover informatics methods for theMS-based identification of molecules including proteins, peptides, andmetabolites and their application to the analysis of large data sets. A
special emphasis will be placed on benchmarking of methods and testing
the significance of their results.

Keywords: Noncovalent complexes, Electrospray ionization, Protein,
Molecular machines, Ion mobility

Keywords: Database searching, Spectrum libraries, de Novo Sequencing,Significance testing, PTM localization

Session 32 (Room A):

Session 35 (Room E):

Keynote: Roman A. Zubarev

Keynote: Terry Bidleman

Formation and Dissociation of Peptide Radical Ions
Chair:
Dominic T.W. Chan
“Formation and Dissociation of Peptide Radical Ions”
Scope of Session: This session focuses on the recent advances in theunderstanding and applications of tandem mass spectrometry of peptides/proteins involving radical intermediates.
Keywords: ECD, ETD, ISD MALDI, Peptide radical ions

Session 33 (Room B-1):

JMS Award Symposium
Chair:
Richard M. Caprioli (Editor-in-Chief, JMS)
Scope of Session: Spectrometry Conferences. The Fifth symposium will
be held in conjunction with the 19th International Mass Spectrometry
Conference, Kyoto, Japan, 15 – 21 September 2012.
5 Postgraduate Awards• 5 awards of $1500 will be made to assist the awardees in travel andattendance at the conference.
• Each winner will receive a complimentary subscription to JMS• The postgraduate student winners will include representatives from
Europe/Africa, Asia/Oceania and the Americas.
• Each winner will present a 15-minute talk on their work in the JMS
Awards Symposium.
• Each winner will receive a certificate and mention in the Journal andhave the opportunity to publish their paper in the journal if they choose.

* The titles of keynote lecture may be subject to change in the final program.

Environment I
Chair: Peter Haglund“Chiral Chemicals as Tracers of Sources and Fate Processes in
a World of Changing Climate”
Scope of Session: To elucidate transport and fate mechanisms for POPs
on a global scale using advanced analytical tools such as congener-specific and enantioselective analysis and efficient data evaluation.
Keywords: POPs, Chiral analysis, Fate of chemicals, Enantioselection,
Congener-specific determination, Source tracking, Arctic environment

[Thursday Afternoon, 20th September (15:00-17:00)]
Session 36 (Main Hall):Advances in Ion Mobility Mass Spectrometry
Chair:
Joseph A Loo
Keynote: Michael T. Bowers“Peptide and protein aggregation: Mechanisms,
inhibition and disease”
Scope of Session: Recent advances in IM-MS instrumentation have」
impacted theanalysis of a wide range of biological molecules, from lipids, carbohydrates, peptides, and nucleic acids to larger macromolecules. The development of new IM-MS instruments and their applications to chemistry
and biology, including proteomics, will be presented.
Keywords: Ion mobility, Conformation, Molecular structure, Protein, Nucleic acids, Lipids

Session 37 (Room A):

Challenges in High Resolution and High Accuracy Mass
Measurement Mass Spectrometry
Chair: Evgeny Nikolaev
Keynote: Alan G. Marshall“Mass Resolution and Mass Accuracy: How Much is Enough?”
Scope of Session: Challenges in high resolution and high accuracy massmeasurement mass spectrometry” will provide a forum to present anddiscuss research concerning mass spectrometry instrumentation, andparticularly instrumentation which can be applied to modern FTMS instruments FT ICR, Orbitraps/Kingdon and Cassini traps, multiple pass
TOF instruments, Zaifman traps, Applications-related topics will include:
applications of ultrahigh resolution and mass accuracy, isotopic resolution of high mass proteins, fine structure of mass peaks, elemental
composition determination from accurate masses, analysis of complex
systems, computational modeling, and more.
Keywords: Instrumentation, High mass resolution, High mass accuracy,
FTMS, FT ICR, Orbitraps/Kingdon traps, Cassini traps, Multiple pass
TOF

Session 38 (Room B-1):

Mass Spectrometry for Metabolic Diseases
Chair: Makoto Yoshino, Seiji Yamaguchi
Scope of Session: Metabolic profiling to find newborn patients with metabolic diseases has long been a key technique of MS working for biochemical and laboratory medicine. Currently, tandem mass spectrometry
is used for the newborn screening to detect the patients with a wide
spectrum of inborn errors of metabolism, and is identifying several aminoacid, organic acid and fatty acid disorders in many countries with different
programs. The Japanese Society for Biomedical Mass Spectrometry(JSBMS), a pioneering society in this field, is organizing this session to
include the technical and clinical aspects of MS for metabolic disorders.

* The titles of keynote lecture may be subject to change in the final program.

Keywords: Inborn errors of metabolism, Screening, Metabolic disease,
Clinical metabolomics, Clinical mass spectrometry

Session 39 (Room D):

MS Informatics for Quantitation
Chair:David Fenyö
Keynote: Jürgen Cox“Detection of differential expression of splice variantsin the MaxQuant framework for quantitative proteomics”
Scope of Session: This session will cover informatics methods to extract
quantitative information from mass spectra. The main focus will be detection and correction interference, testing the significance of measuredchanges inquantity, and applications of the methods to the analysis of large data
sets.
Keywords: Label-free, SILAC, Interference detection, Significance testing

Session 40 (Room E):
Environment II
Chair:
Takeshi Nakano

Keynote: Peter S Haglund“Powerful GC-ToF-MS Techniques for Quantification ofLegacy Pollutants and Screening and Identification of
Emerging Pollutants”
Scope of Session: To develop powerful cost-efficient techniques forquantification of legacy pollutants and screening for emerging pollutants,
including hyphenated techniques and various environmental applications.
Keywords: Emerging pollutants, POPs, PPCPs, Hyphenated techniques,
Polutant characterization, Prioritization, Emission and exposure assessment, Risk evaluation

List of Oral Sessions[Friday Morning, 21st September (9:00-11:00)]
Session 41 (Main Hall):Chemistries of Trapped Ions and their Applications to Biological Mass Spectrometry
Chair:
Gavin E. Reid
Keynote: Scott A. McLuckey“Bioconjugation in the Gas Phase: New Chemistry for Tandem
Mass Spectrometry”
Scope of Session: Ion chemistry plays a critical role in the application ofmass spectrometry for the structural characterization of biological molecules in the gas-phase. This session will focus on highlighting recent
advances in fundamental gas-phase ion chemistry and instrumentation
development, and their application to address challenges in life science
research.
Keywords: Ion activation, Dissociation, MS/MS, Proteomics, Peptide,
Lipidomics, Lipid

Session 42 (Room A):

New Developments in Instruments and Detectors
Chair:
Takaya Sato
Keynote: Evgeny N. Nikolaev“From supercomputer modeling to highest mass resolution in
FT ICR”
Scope of Session: Mass spectrometry is a method to determine the m/zof various compounds ionized in ion source. At the beginning of the lastcentury, the first mass spectrometer was developed for atomic and molecular physics. Since then, various types of mass spectrometer whichuses different manner to achieve mass separation and detection are invented. They cover wide target application, such as from elemental
analysis to protein analysis. The new ideas and improvement of separation techniques or detection technologies are expected to continue expanding range of application. This session aims to present instrumental
developments in mass separation and detection techniques including
simulation or making prototype equipment.
Keywords: Instrumentation, Simulation, Detector, Ion optics

Session 43 (Room B-1):

Novel Proteomics Methodologies
Chair:
Yasushi Ishihama
Keynote: Michael J. MacCoss“Shifting Proteomics from a Hypothesis Generating Workflow toa Hypothesis Testing Workflow”
Scope of Session: Rapid progress has been made in mass spectrometry-based proteomics. However it is still a challenging task to unveil proteome world even when the state-of-the-art proteomics technologies, andnovel methodologies must be developed. This session will focus on the
new proteomics methodologies including SRM quantitation,
post-translational modifications and other methodologies applicable toproteome-wide analysis of cells and tissues.
Keywords: Proteome-wide approach, Quantitation, Post-translational
modification, Protein-protein interactions, In-depth proteome analysis* The titles of keynote lecture may be subject to change in the final program.

Session 44 (Room D):
Ambient Ionization
Chair:
Jentaie Shiea

Keynote: Kenzo Hiraoka“Ambient desorption/ionization mass spectrometry
for minimal samples”
Scope of Session: Ambient ionization mass spectrometry has evolved
and grown to become one of the most important techniques for efficiently
characterizing the analytes from various surfaces and matrices. This
group of the techniques differs from the traditional ionization sources inthat the experiment is performed under ambient conditions without sample preparation. The technique allows direct, real-time, andhigh-throughput analyses and has been successfully applied to different
areas within the life, health and industrial sciences. With the evolution of
new designs, variants, combinations and hybrids; a number of ambient
ionization techniques based on the differences in sampling/desorption (ca.
nebulization, laser desorption/ablation, and thermal desorption) and ionization processes (ca. electrospray ionization and atmospheric pressurechemical ionization) were developed. The main focus of this session will
be on the instrumentation of ambient ionization mass spectrometry andits applications. Potential topics include, but are not limited to:• New ambient ionization sources• Interface for chromatograph and ambient mass spectrometry• Principle of ambient ionization processes• Applications related to food safety and sciences, drug analysis, forensics, environmental chemistry, homeland security, proteomic andmetabolomic studies, molecular imaging, and other chemical and biochemical researches.
Keywords: Ambient, Electrospray ionization, Atmospheric pressurechemical ionization, Sampling, Desorption

Session 45 (Room E):

Cell Biology / Cellular Pathways
Chair:
Renato Zenobi
Keynote: Tsutomu Masujima“Future of Cell Analyses and Mass Spectrometry”
Scope of Session: Mass spectrometry is now a strong analytical tool forcell biology. New methods and updated applications for cellular omics,
cellular pathway analyses and single cell analyses will be discussed inthis session.
Keywords: Single cell analysis, Organella, Intracellular distribution, Microanalysis, Microdisection