Tau Meeting 2024 Program @ Shiga University of Medical Science
Day 1: August 23 (Friday)
13:00-13:05 Opening Remarks (Akihiko Takashima)
13:05-13:10 Announcements from the Secretariat (Shinsuke Ishigaki)
Session 1 (Chair: Shinsuke Ishigaki) - Presentation 18 minutes + Q&A 7 minutes
13:10-13:35 E3 ligase praja1 mediates ubiquitination and degradation of Microtubuleassociated protein Tau- Shiho Aoki, Waseda University of Advanced Science and Engineering
13:35-14:00 Establishing a hiPSC-derived neuron Tau aggregation model and recording
neuronal activity- Naoki Kato, Waseda University14:00-14:25 Tau strain-typing and anti-aggregation effect of artificial Tau mutant- Shotaro Shimonaka, Tokyo Metropolitan Institute of Medical Science(Break 15 minutes)
Session 2 (Chair: Tomohiro Miyasaka) - Presentation 18 minutes + Q&A 7 minutes
14:40-15:05 In Vivo Microdialysis Unveils the Dynamics of Brain Extracellular Fluids:
Changes in Seed-Competent Tau and Proteome Associated with Tau Pathology- Itaru Nishida, University of Tokyo
15:05-15:30 Sleep-wake body temperature regulates tau secretion in mice and correlateswith tau in cerebrospinal fluid and plasma in humans- Emmanuel PLANEL, Laval University
15:30-15:55 A Novel Tauopathy Model Mimicking Molecular and Spatial Aspects of HumanTau Pathology- Rin Yanai, National Institutes for Quantum Science and Technology
15:55-16:20 Impact of tau accumulation on functional brain network for spatial navigation- Riki Koike, Gakushuin University

(Break 15 minutes)
Session 3 (Chair: Naruhiko Sahara) - Presentation 12 minutes + Q&A 3 minutes
16:35-16:50 DNA double-strand break repair defects and tau pathology- Megumi Asada, Shiga University of Medical Science
16:50-17:05 Abnormal behavior and glial response in animal models of tau pathology- Liu Yue, Nagoya University

Day 2: August 24 (Saturday)
Session 4 (Chair: Sumihiro Maeda) - Presentation 18 minutes + Q&A 7 minutes
9:00-9:25 Inducing Different Forms of Tau Using Optogenetics- Tomoya Uchida, Waseda University
9:25-9:50 Aggregation and intracellular changes induced by tau manipulation- Yoshiyuki Soeda, Gakushuin University
9:50-10:15 Degradation of Tau aggregates by aggrephagy induction- Gen Matsumoto, Osaka Metropolitan University
10:15-10:40 Age-related metabolic changes enhance tau-induced neurodegeneration- Kanae Ando, Tokyo Metropolitan University
10:40-11:05 Aberrant cortical activity associated with behavior abnormalities in rTg4510
mouse- Junya Hirokawa, National Institutes for Quantum Science and Technology(Break 10 minutes)

Session 5 (Chair: Yoshiyuki Soeda) - Presentation 12 minutes + Q&A 3 minutes
11:15-11:30 Tau interactome analysis using MAPT knock-in mice
- Shoko Hashimoto, Shiga University of Medical Science
11:30-11:45 Cryo-EM analysis of tau filaments from a case of tauopathy with VCP mutation- Masato Hasegawa and Shin-ishi Hisanaga, Tokyo Metropolitan Institute of Medical Science
11:45-12:00 The effect of lansoprazole on tau aggregation- Yumiko Motoi, Juntendo University School of Medicine
12:00-12:15 Exploratory study on factors affecting the formation of tau pathology in themouse genetic background- Daijiro Yanagisawa, Shiga University of Medical Science
12:15 Closing Remarks (Akihiko Takashima)