■はじめに
藤本 大三郎（東京農工大学名誉教授）
1) 野田春彦、永井裕、藤本大三郎編、コラーゲン、南江堂、1975
2) 永井裕、藤本大三郎編、コラーゲン代謝と疾患、講談社サイエンティフィック、1982
3) 永井裕、藤本大三郎編、コラーゲン実験法、講談社サイエンティフィック、1985
4) 藤本大三郎編、細胞外マトリックスのバイオサイエンスとバイオテクノロジー、アイピーシー、1990
5) 坂倉照妤編、細胞外マトリックス、羊土社、1995
6) 小出輝，林利彦編、細胞外マトリックス ―基礎と臨床―、愛智出版、2000

■第 1 章 定義
西山 敏夫（東京農工大学名誉教授）
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■第 2 章 コラーゲンファミリー水野 一乘（株式会社ニッピバイオマトリックス研究所）
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■第 3 章 コラーゲンの構造と物性
野村 義宏（東京農工大学農学部附属硬蛋白質利用研究施設）
K. L. Goh（Newcastle University in Singapore）
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■第 5 章 生合成(1)：総論
石川善弘（カリフォルニア大学サンフランシスコ校医学部眼科）
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■第 7 章 生合成(3)：クロスリンク（架橋）山内 三男（ノースカロライナ大学チャペルヒル校 Division, Oral and Craniofacial Health Sciences）
寺嶋 雅彦（ノースカロライナ大学チャペルヒル校 Division, Oral and Craniofacial Health Sciences）
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伊藤 義文（オックスフォード大学ケネディーリウマチ研究所）
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■第 10 章 合成コラーゲン
黒田 一稀（早稲田大学先進理工学部化学・生命化学科）
小出 隆規（早稲田大学先進理工学部化学・生命化学科）
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■第 11 章 消化と吸収
佐藤 健司（京都大学大学院農学研究科応用生物科学専攻海洋生物機能学分野）
重村 泰毅（東京家政大学家政学部／短期大学部栄養学科）
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■第 12 章 哺乳動物由来コラーゲン
田中 啓友（株式会社ニッピバイオマトリックス研究所）
服部 俊治（株式会社ニッピバイオマトリックス研究所）
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藤本大三郎編「細胞外マトリックスのバイオサイエン

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■第 13 章 水産動物由来コラーゲン
石原 賢司（国立研究開発法人水産研究・教育機構水産技術研究所）
平岡 芳信（一般社団法人愛媛県発明協会）
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編 恒星社厚生閣(東京). 1989; pp. 81-99.
19) 石原賢司・小山田千秋・土居幹治・松本淳一・白石隆介・平岡芳信・園田浩二，カツオの中骨を原料とするコラーゲンペプチドの製造方法. 特開 2012-244930.
20) 雑賀愛・岩井浩二・高畑能久，血圧上昇抑制作用を有するペプチド. 特願 2008-506354.
21) Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Higashi A, Kido Y, Nakabo Y,
Ohtsuki K, Identification of food-derived collagen peptides in human blood after oral ingestionof gelatin hydrolysates. J. Agric. Food Chem. 2005; 53: 6531-6536.
22) 重村泰毅，魚類由来タンパク質加水分解物摂取後のヒト体調改善効果の予測されるメカニズム. 日本食生活学会誌. 2016; 27: 147-152.

■第 14 章 下等動物由来コラーゲン
新井 克彦（東京農工大学農学部附属硬蛋白質利用研究施設）
1) Parisi JR, Fernandes KR, Avanzi IR, Dorileo BP, Santana AF, Andrade AL, Gabbai-Armelin PR,
Fortulan CA, Trichês ES, Granito RN, Renno ACM. Incorporation of Collagen from Marine Sponges(Spongin) into Hydroxyapatite Samples: Characterization and In Vitro Biological Evaluation. Mar
Biotechnol (NY). 2019. 21: 30-37.
2) Draper GW, Shoemark DK, Adams JC. Modelling the early evolution of extracellular matrix frommodern Ctenophores and Sponges. Essays Biochem. 2019. 63:389-405.
3) Boute N, Exposito JY, Boury-Esnault N, Vacelet J, Noro N, Miyazaki K, Yoshizato K, Garrone R.
Type IV collagen in sponges, the missing link in basement membrane ubiquity. Biol Cell. 1996.
88:37-44.
4) Exposito JY, Cluzel C, Garrone R, Lethias C. Evolution of collagens. Anat Rec. 2002. 268: 302316.
5) Aouacheria A, Geourjon C, Aghajari N, Navratil V, Deléage G, Lethias C, Exposito JY. Insights
into early extracellular matrix evolution: spongin short chain collagen-related proteins arehomologous to basement membrane type IV collagens and form a novel family widely distributed ininvertebrates. Mol Biol Evol. 2006. 23: 2288-2302.
6) Ehrlich H, Wysokowski M, Żółtowska-Aksamitowska S, Petrenko I, Jesionowski T. Collagens ofPoriferan Origin. Mar Drugs. 2018. 16: E79.
7) Tziveleka LA, Ioannou E, Tsiourvas D, Berillis P, Foufa E, Roussis V. Collagen from the Marine
Sponges Axinella cannabina and Suberites carnosus: Isolation and Morphological, Biochemical, andBiophysical Characterization. Mar Drugs. 2017. 15: E152.
8) Miura S, Kimura S. Jellyfish mesogloea collagen. Characterization of molecules as alpha 1 alpha2 alpha 3 heterotrimers. J Biol Chem. 1985. 260:15352-15356.
9) Addad S, Exposito JY, Faye C, Ricard-Blum S, Lethias C. Isolation, characterization andbiological evaluation of jellyfish collagen for use in biomedical applications. Mar Drugs. 2011.
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10) Miki A, Inaba S, Baba T, Kihira K, Fukada H, Oda M. Structural and physical properties ofcollagen extracted from moon jellyfish under neutral pH conditions. Biosci Biotechnol Biochem.
2015. 79: 1603-1607.
11) Wang W, Omori M, Hayashibara T, Shimoike K, Hatta M, Sugiyama T, Fujisawa T. Isolation andcharacterization of a mini-collagen gene encoding a nematocyst capsule protein from a reefbuilding coral, Acropora donei. Gene. 1995. 152: 195-200.
12) Engel U, Pertz O, Fauser C, Engel J, David CN, Holstein TW. A switch in disulfide linkage
during minicollagen assembly in Hydra nematocysts. EMBO J. 2001. 20: 3063-3073.

13) Shpirer E, Chang ES, Diamant A, Rubinstein N, Cartwright P1, Huchon D. Diversity and evolutionof myxozoan minicollagens and nematogalectins. BMC Evol Biol. 2014. 14:205.
14) Yoneda C, Ahsan MN, Nakaya M, Matsubara Y, Ebihara T, Irie S, Uno Y, Hatae K, Watabe S.
Abalone collagens: immunological properties and seasonal changes of their mRNA levels. Comp
Biochem Physiol B Biochem Mol Biol. 2000. 126: 59-68.
15) Badiu DL, Luque R, Dumitrescu E, Craciun A, Dinca D. Amino acids from Mytilus galloprovincialis(L.) and Rapana venosa molluscs accelerate skin wounds healing via enhancement of dermal andepidermal neoformation. Protein J. 2010 29:81-92.
16) Kimura S, Nagaoka Y, Kubota M. Studies on marine invertebrate collagens- I. Some collagens
from crustaceans and molluscs. Bull. Japan. Soc. Sci. Fish. 1969. 35: 743-748.
17) Nagai T. Collagen from diamondback squid (Thysanoteuthis rhombus) outer skin. Z NaturforschC. 2004. 59:271-275.
18) Sivakumar P, Chandrakasan G. Occurrence of a novel collagen with three distinct chains in the
cranial cartilage of the squid Sepia officinalis: comparison with shark cartilage collagen.
Biochim Biophys Acta. 1998. 1381:161-169.
19) Kimura S, Takema Y, Kubota M. Octopus skin collagen. Isolation and characterization of collagencomprising two distinct alpha chains. J Biol Chem. 1981. 256:13230-13234.
20) Johnstone IL. Cuticle collagen genes. Expression in Caenorhabditis elegans. Trends Genet.
2000. 16:21-27.
21) Ashhurst DE, Bailey AJ. Locust collagen: morphological and biochemical characterization. Eur
J Biochem. 1980. 103: 75-83.
22) Cecchini JP, Knibiehler B, Mirre C, Le Parco Y. Evidence for a type-IV-related collagen in
Drosophila melanogaster. Evolutionary constancy of the carboxyl-terminal noncollagenous domain.
Eur J Biochem. 1987. 165: 587-593.
23) Wang X, Harris RE, Bayston LJ, Ashe HL. Type IV collagens regulate BMP signalling in Drosophila.
Nature. 2008. 455: 72-77.
24) Baerwald RJ, Williamson LC, Stevens E, Rike C, Trabanino S, Carlton J. Isolation,
ultrastructure, and partial characterization of collagen from the perineurium of the Florida
lobster, Panulirus argus. Biochem Cell Biol. 1991. 69: 531-536.
25) Sivakumar P, Suguna L, Chandrakasan G. Molecular species of collagen in the intramuscularconnective tissues of the marine crab, Scylla serrata. Comp Biochem Physiol B Biochem Mol Biol.
2000. 125:555-562.
26) Trotter JA, Thurmond FA, Koob TJ. Molecular structure and functional morphology of echinoderm
collagen fibrils. Cell Tissue Res. 1994. 275: 451-458.
27) Motokawa T. Connective tissue catch in echinoderms. Biol
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28) Adibzadeh N, Aminzadeh S, Jamili S, Karkhane AA, Farrokhi N. Purification and characterizationof pepsin-solubilized collagen from skin of sea cucumber Holothuria parva. Appl Biochem Biotechnol.
2014. 173: 143-154.
29) Zhong M, Chen T, Hu C, Ren C. Isolation and characterization of collagen from the body wallof sea cucumber Stichopus monotuberculatus. J Food Sci. 2015. 80:C671-679.
30) Ovaska M, Bertalan Z, Miksic A, Sugni M, Di Benedetto C, Ferrario C, Leggio L, Guidetti L,
Alava MJ, La Porta CAM, Zapperi S. Deformation and fracture of echinoderm collagen networks. J
Mech Behav Biomed Mater. 2017. 65: 42-52.

■第 15 章 機能性素材としての利用
野村 義宏（東京農工大学農学部附属硬蛋白質利用研究施設）
1) 野村義宏 コラーゲン今昔物語～はじめに～ 皮革科学 58(2) 47-50(2012)2) 竹ノ内一昭 古代の皮革 4.東・南アジア 皮革科学 1-5(200)3) 竹ノ内一昭 古代の皮革 5 東・日本 皮革科学 1-6(200)4) 千賀久 古墳時代の革製品 皮革科学 50，129（2004）
5) Egypt unveils biggest ancient coffin find in over a century, REUTERS Oct 19, 2019https://www.reuters.com/article/us-egypt-archaeology-luxor/egypt-unveils-biggest-ancient-coffinfind-in-over-a-century-idUSKBN1WY0C5
6) 綿谷正之 墨の文化史 概説 奈良保育学院 研究紀要 1-34 (2014)7) 高田俊二

写真産業の技術革新史―その 1

乳剤時代の幕開けと感光材料の工業化

日本写真学会誌

77(2), 76-82(2014)
8) RL Madox, British J Photo, 18 422(1871)9) 野村義宏 コラーゲン今昔物語～コラーゲンの利用分野～ 皮革科学 58(3) 93-99(2012)
10) T Nishihara, T Miyata, Collagen symposium, 3, 66-93 (1962)
11) T Fujii, Hoppe-Seylers Z Physol Chem, 350, 1257-1265 (1969)
12) 野村義宏 コラーゲン今昔物語～医療用途でのコラーゲンの活用～ 皮革科学 59(3), 99-106 (2013)13) 野村義宏 コラーゲン今昔物語～可食性フィルム～ 皮革科学 60(1) 1-5 (2014)14) E Bell, B Ivarsson, C Merrill, Proc Natl Acad Sci USA, 76, 1274-1278 (1979)

■第 16 章 皮革および製品
吉村 圭司（一般社団法人日本皮革産業連合会）
1) O'Sullivan NJ, Teasdale MD, Mattiangeli V, Maixner F, Pinhasi R, Bradley DG, Zink A. A whole
mitochondria analysis of the Tyrolean Iceman's leather provides insights into the animal sourcesof Copper Age clothing. Scientific Reports. 2016; 6, 31279
2) https://leathercouncil.org/information/statistics-sources-of-information/3) www.fao.org/faostat/" www.fao.org/faostat/4) 日本皮革技術協会皮革ハンドブック編集委員会, 皮革ハンドブック, 樹芸書房, 2005，p24.
5) Buljan J, Kral I. The framework for sustainable leather manufacture. 2nd ed. UNIDO, 2018. p.22.
6) Covington AD. Tanning chemistry,, The science of leather, The Royal Society of Chemistry (UK);2009, p284.
7) 日本皮革技術協会, 新版皮革科学, 日本皮革技術協会, 1992, p53-56.
8)http://japanecoleather.jp/%e6%97%a5%e6%9c%ac%e3%82%a8%e3%82%b3%e3%83%ac%e3%82%b6%e3%83%bc%e3%81%a8%e3%81%af/%ef%bc%96%e3%81%a4%e3%81%ae%e6%9d%a1%e4%bb%b6/9) Ogata K, Kumazawa K, Koyama Y, Yoshimura K, Takahashi K, Complete inhibition of hexavalentchromium formation from chrome-tanned leather with combined inhibitiors, J Soc Leather Technol
Chem, 101, 27-32, 2017.
10) Ogata K, Kumazawa K, Hattori S, Yoshimura K, Takahashi K, Self-conversion of hexavalentchromium formed in chrome-tanned leather during long-term storage and perfect inhibition with a
combination of inhibitiors, J Soc Leather Technol Chem, 102, 53-58, 2018.
11) Ogata K, Inatsugi Y, Hattori S, Kumazawa K, Yoshimura K, Takahashi K, Pilot production ofchrome-tanned leather without formation of hexavalent chromium by treatment with a combination of
inhibitiors, J Soc Leather Technol Chem, 103, 1-6, 2019.

■第 17 章 和膠と洋膠
土居 昌裕（旭陽化学工株式会社）
1) https://dictionary.jlia.or.jp/detail.php?id=1933
2) http://urakami.com/nikawa.html
3) パギイ法 写真用ゼラチン試験法 第 10 版(2006 年度版
4) 日本にかわ・ゼラチン工業組合： にかわとゼラチン
5) 膠文化財研究会： 膠の基礎知識
6) 渡部睦人、野村義宏： コラーゲン今昔物語 膠とゼラチン
7) 関 出： 日本画とにかわ 兵庫県バイオポリマー研究会
8) 土居昌裕： 三千本膠「飛鳥」の開発について 愛知県立大学講演要旨
9) 宇髙健太郎, 野村義宏, 寺岡葉子：膠製造における諸条件と製品の性状の関連(3) -製造条件と物性決定
因子-. 文化財保存修復学会第 34 回大会研究発表要旨集; 201210) 大野隆司：写真用ゼラチンの最近の傾向 日本写真学会誌 52, 320-322 (1989)
11) 伊藤典一：最近の写真用ゼラチンの製法 日本写真学会誌 52, 329-331 (1989)12) 戸田雄三：銀塩感光材料における写真用ゼラチンの役割 日本写真学会誌 52, 323-328(1989)13) 久米裕二：国立博物館

技術の系統化調査報告書 第 17 集、カラーネガフィルムの技術系統化調査 独

国立科学博物館 産業技術史資料情報センター 275-363（2012）14) 高田俊二：写真産業の技術革新史-その 1 乳剤時代の幕開けと感光材料の工業化 日本写真学会誌 77,76-82(2014)15) 高田俊二：写真産業の技術革新史-その 2

乳剤高感度化技術と写真・映像の大衆化

78, 23-31(2015)16) 小林 隆：ゼラチンの物性評価とその標準化 日本写真学会誌 67, 386-391 (2004)

日本写真学会誌

■第 18 墨および古典的膠宇髙 健太郎（独立行政法人国立文化財機構東京文化財研究所）
1) TERADA Torahiko, YAMAMOTO Ryuzo. Experimental studies on colloid nature of Chinese black ink
Part I. Scientific Papers of the Institute of Physical and Chemical Research 23; 1934
2) TERADA Torahiko, YAMAMOTO Ryuzo. Experimental Studies on Colloid Nature of Chinese Black Ink,
Part II, Scientific Papers of the Institute of Physical and Chemical Research 27; 1935
3) 飯島茂. 硯墨新語. 雄山閣; 1935
4) 宮坂和雄. 墨と色材の知識. 木耳社; 1972
5) 宮坂和雄, 斉藤昌子, 有馬智加子, 片岡友子. 墨の粒子の定着状態と墨色に関する研究. 共立女子大学
家政学部紀要 20; 1974
6) 小口八郎. 墨の研究. 古文化財之科学 文化財保存修復学会誌 20・21 (1977)
7) 編 宇野健一. 徳川美術館蔵 古墨. しこうしゃ図書販売; 1991
8) Joseph R. Swider, Vincent A. Hackley, John Winter. Characterization of Chinese Ink in Size andSurface. Journal of Cultural Heritage 4; 20039) 日野楠雄. 墨色の変化 -紙と墨と水と- 宣紙〜楮紙へ、にじみの世界. 和紙文化研究 17; 200910) 為近磨巨登. 写真で知る墨・硯・紙. 木耳社; 200911) 為近磨巨登. 書道用紙とにじみ. 木耳社; 201112) 宇髙健太郎. 古典絵画における墨の研究 付論：伊藤若冲紙本墨画作品の復元模写による検証. 東京藝術大学博士研究論文; 201313) 宇髙健太郎, 早川典子, 北田克己, 森田恒之, 荒井経, 稲葉政満, 半田昌規, 斎藤典彦. 膠の基礎知
識. 膠文化研究会; 201514) UDAKA Kentaro, HAYAKAWA Noriko, KITADA Katsumi, MORITA Tsuneyuki, ARAI Kei, INABA Masamitsu,
HANDA Masaki, SAITO Norihiko, MATSUBARA Michiko. Basic Knowledge about Animal Glue. Nikawa Labs;
201715) 岡岩太郎, 小笠原具子, 佐藤千晴. 粉状化した白色顔料の剥落止めに用いる膠の検討 〜宇髙健太郎氏
作製古典的膠と中川胡粉製播州粒膠の使用を例に〜. 鳳翔学叢第 13 輯. 平等院; 201716) 早川典子. 平等院鳳凰堂東面中央扉に使用した剥落止め材料について. 鳳翔学叢第 13 輯. 平等院;
201717) 宇髙健太郎. 膠の性状と装潢における適性, 膠文化研究会第 11 回公開研究会「膠と修理 -《序の舞》
を守る-. 予稿集; 201818) 宇髙健太郎. 文化財修復における膠の適性. 膠文化研究会第 12 回公開研究会「膠千年」予稿集; 201919) 宇野雪村. 必携 文房古玩事典. 柏書房株式会社; 1983
20) 編 東京藝術大学大学院文化財保存学日本画研究室. 図解 日本画用語事典. ㈱東京美術; 200721) 編集委員長 加藤時雄. カーボンブラック便覧 <第三版>. カーボンブラック協会; 199522) 宇髙健太郎. 煤製造における諸条件と製品の性状の関連. 文化財保存修復学会第 35 回大会研究発表要旨集; 201423) 宇髙健太郎. 煤及び膠に関する研究. 文化財保存修復学会第 37 回大会研究発表要旨集; 201524) 宇髙健太郎. 松煙煤に関する研究. 文化財保存修復学会第 40 回大会研究発表要旨; 201825) UDAKA Kentaro, Jennifer A. Giaccai. Research on Properties of Soot for Inkstick Productions.
Collection of research presentations of the 42nd Annual Meeting of the Japan Society for theConservation of Cultural Property; 202026) 宇髙健太郎. 膠製造における諸条件と製品の性状の関連. 文化財保存修復学会第 33 回大会研究発表要旨集; 2011
27) 宇髙健太郎. 膠製造における諸条件と製品の性状の関連(2) -製造条件と界面性状等-. 文化財保存修復
学会第 34 回大会研究発表要旨集; 201228) 宇髙健太郎, 野村義宏, 寺岡葉子. 膠製造における諸条件と製品の性状の関連(3) -製造条件と物性決定因子-. 文化財保存修復学会第 34 回大会研究発表要旨集; 201229) 宇髙健太郎. 膠製造における諸条件と製品の性状の関連(4). 文化財保存修復学会第 35 回大会研究発表
要旨集; 201330) 宇髙健太郎. 膠製造における諸条件と製品の性状の関連(5). 文化財保存修復学会第 36 回大会研究発表
要旨集; 201431) 宇髙健太郎. 膠の性状に関する研究. 文化財保存修復学会第 38 回大会研究発表要旨集; 201632) 宇髙健太郎, 早川典子, 半田昌規, 岡泰央, 藤井佑果, 小笠原具子, 亀井亮子, 半田幾子, 宇和川史彦, 柏谷明美. 膠の性状と装潢における適性の関連. 文化財保存修復学会第 39 回大会研究発表要旨集;
201733) 宇髙健太郎, 早川典子, 藤井佑果, 大場詩野子, 岡部迪子, 柏谷明美. 膠の調製等に関する研究. 文化
財保存修復学会第 41 回大会研究発表要旨集; 201934) 宇髙健太郎, 早川典子, 藤井佑果, 柏谷明美. 膠の性状と湿熱劣化処理の影響に関する研究 -表面観察による検証-. 保存科学 58; 201935) 宇髙健太郎, 早川典子, 藤井佑果, 大場詩野子, 岡部迪子. 古典的膠の調製方法及び性状. 文化財保存
修復学会第 42 回大会研究発表集; 202036) 鈴木梅仙. 梅仙墨談; 189737) 松尾良樹、的場美帆. 『唐人墨製問答之記録』-「古梅園製墨資料」翻刻と解題(2)-. 古代学 4; 201238) 濱田薫. 残笏居 古墨記言; 200739) 訳編 赤堀昭. 中国製墨資料. 呉竹精昇堂; 198640) 輯 陶湘. 渉園墨萃. 中國書店; 1991 (原典 中華民国期-宋代)
41) 渡邉明義. 水墨画の鑑賞基礎知識. ㈱至文堂; 199742) 仙石正. 新・墨談. 内田老鶴圃新社; 197143) 綿谷正之. 墨の文化史 概説. 奈良保育学院研究紀要 16; 201444) All Japan Handmede Washi Association. Handbook on the Art of Washi. Wagami-do K.K.; 199145) 編 馬淵久夫, 杉下龍一郎, 三輪嘉六, 沢田正昭, 三浦定俊. 文化財科学の事典. ㈱朝倉書店; 2003

46) 潘吉星, 訳 佐藤武敏. 中國製紙技術史. ㈱平凡社; 1990
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■第 19 章 コラーゲンを利用した食品
鈴木 哲（株式会社ニッピ富士工場）
1) 和田正汎, 長谷川忠男, コラーゲンとゼラチンの科学, 2011 年
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7) 鈴木哲, ゼラチンの基本物性と応用アプリケーション, フードケミカル, 2011 年;11:39-44
8) 金谷節子, ベッドサイドから在宅で使える 嚥下食のすべて 医歯薬出版株式会社
9) 小原仁，土居守，摂食・嚥下障害を有する慢性期リハビリテーション患者におけるゼラチンを活用した嚥
下障害食の栄養状態に対する効果、栄養学会誌 Vol.64、No.4、237-242（2006 年）
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with calcitonin and a diet rich in collagen proteins, Cas Lek Cesk, 1996; 135: 74-8
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13) 角田愛美, 広田亜里沙, 桑葉くみ子, 楠畑雅, 小山洋一, 新谷隆行 et al, 皮膚角層の吸水能と血液性
化学検査に対するコラーゲンペプチド経口摂取の作用, Journal of Nutritional Food, 2004 年; 7: 45-52
14) Aaron M.Altschul, タンパク質 －その化学と栄養政策－ 昭和 42 年、光琳書院
15) 日本食品標準成分表 2015 年版（七訂）■第 20 章 機能性食品
小泉 聖子（新田ゼラチン株式会社総合研究所）
松下 綾（新田ゼラチン株式会社総合研究所）
大門 桃茄（新田ゼラチン株式会社総合研究所）
姫野 愛（新田ゼラチン株式会社総合研究所）
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■第 21 章 化粧品分野のコラーゲン
天野 聡（株式会社資生堂グローバルイノベーションセンター）
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■第 22 章 医療用コラーゲン
藤本 一朗（株式会社高研研究所）
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