IFI Recommendation for Society No.5

February 2024

フレイル予防を軸とした
健康⻑寿・幸福⻑寿まちづくりの実現に向けた提⾔飯島 勝⽮

東京⼤学未来ビジョン研究センター 教授/東京⼤学⾼齢社会総合研究機構 機構⻑

孫 輔卿

東京⼤学未来ビジョン研究センター 特任准教授/東京⼤学⾼齢社会総合研究機構 特任准教授

⽥中 友規

東京⼤学⾼齢社会総合研究機構 特任助教

コスタンティーニ・ヒロコ

東京⼤学未来ビジョン研究センター 特任助教/東京⼤学⾼齢社会総合研究機構 特任助教

呂 瑋達
東京⼤学⼤学院医学系研究科 博⼠課程
東京⼤学活⼒ある超⾼齢社会を共創するグローバル・リーダー養成プログラム(GLAFS)

吉澤 裕世

東京⼤学未来ビジョン研究センター 客員研究員/東京⼤学⾼齢社会総合研究機構 客員研究員

前⽥ 展弘

東京⼤学未来ビジョン研究センター 客員研究員/東京⼤学⾼齢社会総合研究機構 客員研究員

神⾕ 哲郎

東京⼤学⾼齢社会総合研究機構 学術専⾨職員

辻 哲夫

東京⼤学未来ビジョン研究センター 客員研究員/東京⼤学⾼齢社会総合研究機構 客員研究員

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Society 5.0 (ICT/IoT)

SDGs

World Health Organization WHO

Ageing (2020-2030)

10

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34

37

Lyu W, Tanaka T, Son BK, Yoshizawa Y, Akishita M, Iijima K. (2024). "Validity of a simple self-reported
questionnaire 'Eleven-Check' for screening of frailty in Japanese community-dwelling older adults: Kashiwa cohort
study." Arch Gerontol Geriatr, 117, 105257. doi: 10.1016/j.archger.2023.105257

Kawamura J, Tanaka T, Kanno S, Osawa K, Okabayashi K, Hirano H, Shirobe M, Nagatani M, Son BK, Lyu W,
Iijima K. (2024). "Relationship between a gum-chewing routine and oral, physical, and cognitive functions ofcommunity-dwelling older adults: A Kashiwa cohort study." Geriatr Gerontol Int, 24(1), 68-74. doi:
10.1111/ggi.14757

Sano K, Lyu W, Uehara Y, Sudo Yumiko, Maki A; Son BK; Tanaka T, Iijima K, (2024). "Comparison between
moving speed in simulated home environment measured by millimeter wave sensor and usual gait speed incommunity-dwelling older adults." Experimental Gerontology.
Oral Frailty Five-item Checklist: OF-5
Tanaka T, Hirano H, Ikebe K, Ueda T, Iwasaki M, Shirobe M, Minakuchi S, Akishita M, Arai H, Iijima K. (2023).
"Oral frailty five-item checklist to predict adverse health outcomes in community-dwelling older adults: A Kashiwa
cohort study." Geriatr Gerontol Int, 23(9), 651-659. doi: 10.1111/ggi.14634

Tanaka T, Akishita M, Kojima T, Son BK, Iijima K. (2023). "Polypharmacy with potentially inappropriate
medications as a risk factor of new onset sarcopenia among community-dwelling Japanese older adults: a 9-year
Kashiwa cohort study." BMC Geriatr, 23(1), 390. doi: 10.1186/s12877-023-04012-y

Nagatani M, Tanaka T, Son BK, Kawamura J, Tagomori J, Hirano H, Shirobe M, Iijima K. (2023). "Oral frailty as arisk factor for mild cognitive impairment in community-dwelling older adults: Kashiwa study." Exp Gerontol, 172,
112075. doi: 10.1016/j.exger.2022.112075

Nishimoto M, Tanaka T, Hirano H, Watanabe Y, Ohara Y, Shirobe M, Iijima K. (2023). "Severe Periodontitis
Increases the Risk of Oral Frailty: A Six-Year Follow-Up Study from Kashiwa Cohort Study." Geriatrics, 8(1), 25.
doi: 10.3390/geriatrics8010025

38

CAMCAM
Hidaka R, Masuda Y, Ogawa K, Tanaka T, Kanazawa M, Suzuki K, Stading M, Iijima K, Matsuo K, (2023). "Impactof the Comprehensive Awareness Modification of Mouth, Chewing and Meal (CAMCAM) program on the attitudeand behavior towards oral health and eating habits as well as the condition of oral frailty." J Nutr Health Aging. doi:
10.1007/s12603-023-1913-1

Tanaka T, Yoshizawa Y, Kitamura K, Sugaya K, Miyajima K, Tsuneoka M, Son BK, Lyu W, Tsushita K, Iijima K,(2023). "Frailty determined by the Questionnaire for Medical Checkup of Old-Old is correlated with increased
healthcare cost: Using the Japanese health insurance database system." Geriatr Gerontol Int. doi: 10.1111/ggi.14711

Tanaka T, Yoshizawa Y, Sugaya K, Yoshida M, Son BK, Lyu W, Tsushita K, Iijima K, (2023). "Predictive validityof the Questionnaire for Medical Checkup of Old-Old for functional disability: Using the National Health Insurance
Database System." Geriatr Gerontol Int. doi: 10.1111/ggi.14533

Lyu W, Tanaka T, Bo-Kyung S, Yoshizawa Y, Akishita M, Iijima K. (2023). "Integrated effects of nutrition-related,
physical, and social factors on frailty among community-dwelling older adults: A 7-year follow-up from the Kashiwa
cohort study." Geriatr Gerontol Int. doi: 10.1111/ggi.14734

Lyu W, Tanaka T, Son BK, Yoshizawa Y, Akishita M, Iijima K. (2022). "Associations of Nutrition-Related, Physical,
and Social Factors and Their Combinations with Sarcopenia in Community-Dwelling Older Adults: Kashiwa Cohort
Study." Nutrients, 14(17), 3544. doi: 10.3390/nu14173544

Lyu W, Tanaka T, Son BK, Akishita M, Iijima K. (2022). "Associations of multi-faceted factors and their
combinations with frailty in Japanese community-dwelling older adults: Kashiwa cohort study." Arch Gerontol
Geriatr, 102, 104734. doi: 10.1016/j.archger.2022.104734

Takase M, Takahashi K, Ogino R, Nitanai R, Tanaka T, Saisho S, Goto J, Iijima K. (2022). "Functional capacity incommunity-dwelling older adults maintained by a higher friend network than family network: implications from a
two-year longitudinal study." BMC Res Notes, 15(1), 319. doi: 10.1186/s13104-022-06216-8

39

Tanaka T, Son BK, Lyu W, Iijima K. (2022). "Impact of social engagement on the development of sarcopenia amongcommunity-dwelling older adults: A Kashiwa cohort study." Geriatr Gerontol Int, 22(5), 384-391. doi:
10.1111/ggi.14372

Iwasaki M, Ohara Y, Motokawa K, Hayakawa M, Shirobe M, Edahiro A, Watanabe Y, Awata S, Okamura T, Inagaki
H, Sakuma N, Obuchi S, Kawai H, Ejiri M, Ito K, Fujiwara Y, Kitamura A, Nofuji Y, Abe T, Iijima K, Tanaka T,
Son BK, Shinkai S, Hirano H, (2022). "Population-based reference values for tongue pressure in Japanese older adults:
a pooled analysis of over 5,000 participants." J Prosthodont Res. doi: 10.2186/jpr.JPR_D_21_00272

Sakai K, Nakayama E, Yoneoka D, Sakata N, Iijima K, Tanaka T, Hayashi K, Sakuma K, Hoshino E, (2022).
"Association of Oral Function and Dysphagia with Frailty and Sarcopenia in Community-Dwelling Older Adults: A
Systematic Review and Meta-Analysis." Cells. doi: 10.3390/cells11142199
Shirobe M, Watanabe Y, Tanaka T, Hirano H, Kikutani T, Nakajo K, Sato T, Furuya J, Minakuchi S, Iijima K, (2022).
"Effect of an Oral Frailty Measures Program on Community-Dwelling Elderly people —A Cluster Randomized
Controlled Trial." Gerontology.

Takahashi K, Tanaka T, Yoshizawa Y, Fujisaki-Sueda-Sakai M, Son BK, Iijima K, (2022). "Lower urinary tract
symptoms and functional ability in older adults: a community-based cross-sectional study." BMJ Open. doi:
10.1136/bmjopen-2021-054530

Yamamoto T, Tanaka T, Hirano H, Mochida Y, Iijima K, (2022). "Model to Predict Oral Frailty Based on
Questionnaire: A Cross-Sectional Study." Int J Environ Res Public Health. doi: 10.3390/ijerph192013244

Chen LK, Iijima K, Shimada H, Arai H, (2022). "Community re-designs for healthy longevity: Japan and Taiwan
examples." Arch Gerontol Geriatr. doi: 10.1016/j.archger.2022.104875

Yoshizawa Y, Tanaka T, Takahashi K, Fujisaki-Sueda-Sakai M, Son BK, Iijima K. (2021). "Impact of Health Literacy
on the Progression of Frailty after 4 Years among Community-Dwelling Older Adults." Int J Environ Res Public
Health, 19(1), 394. doi: 10.3390/ijerph19010394

40

Son BK, Akishita M, Yamanaka T, Toyoshima K, Tanaka T, Suthutvoravut U, Iijima K. (2021). "Association between
inflammatory potential of the diet and sarcopenia/its components in community-dwelling older Japanese men." Arch
Gerontol Geriatr, 97, 104481. doi: 10.1016/j.archger.2021.104481
Oral Frailty Index-8
Tanaka T, Hirano H, Ohara Y, Nishimoto M, Iijima K. (2021). "Oral Frailty Index-8 in the risk assessment of newonset oral frailty and functional disability among community-dwelling older adults." Arch Gerontol Geriatr, 94,
104340. doi: 10.1016/j.archger.2021.104340
AI
Umeda-Kameyama Y, Kameyama M, Tanaka T, Son BK, Kojima T, Fukasawa M, Iizuka T, Ogawa S, Iijima K,
Akishita M. (2021). "Screening of Alzheimer's disease by facial complexion using artificial intelligence." Aging(Albany NY), 13(2), 1765-1772. doi: 10.18632/aging.202545

Tanaka T, Kawahara T, Aono H, Yamada S, Ishizuka S, Takahashi K, Iijima K. (2021). "A comparison of sarcopenia
prevalence between former Tokyo 1964 Olympic athletes and general community-dwelling older adults." J Cachexia
Sarcopenia Muscle, 12(2), 339-349. doi: 10.1002/jcsm.12663

A qualitative study T, Nishita Y, Jeong S, Shimada H, Otsuka R, Kondo K, Kim H, Fujiwara Y, Awata S, Kitamura
A, Obuchi S, Iijima K, Yoshimura N, Watanabe S, Yamada M, Toba K, Makizako H. (2021). "Are Japanese Older
Adults Rejuvenating? Changes in Health-Related Measures Among Older Community Dwellers in the Last Decade."
Rejuvenation Res, 24(1), 37-48. doi: 10.1089/rej.2019.2291

Makizako H, Nishita Y, Jeong S, Otsuka R, Shimada H, Iijima K, Obuchi S, Kim H, Kitamura A, Ohara Y, Awata S,
Yoshimura N, Yamada M, Toba K, Suzuki T. (2021). " Trends in prevalence of frailty in Japan: A meta-analysis fromthe ILSA-J." J Frailty Aging, 10(3), 211-218. doi: 10.14283/jfa.2020.68

Suzuki T, Nishita Y, Jeong S, Shimada H, Otsuka R, Kondo K, Kim H, Fujiwara Y, Awata S, Kitamura A, Obuchi S,
Iijima K, Yoshimura N, Watanabe S, Yamada M, Toba K, and Makizako H, (2021). "Are Japanese Older Adults
Rejuvenating? Changes in Health-Related Measures Among Older Community Dwellers in the Last Decade."
Rejuvenation Research. doi: 10.1089/rej.2019.2291

Iijima K, Arai H, Akishita M, Endo T, Ogasawara K, Kashihara N, Hayashi YK, Yumura W, Yokode M, Ouchi Y,(2021). "Toward the development of a vibrant, super-aged society: The future of medicine and society in Japan."Geriatr Gerontol Int. doi: 10.1111/ggi.14201

41Murakami M, Iijima K, Watanabe Y, Tanaka T, Iwasa Y, Edahiro A, Ohara Y, Motokawa K, Shirobe M, Hirano H.
(2020). "Development of a simple method to measure masseter muscle mass." Gerodontology, 37(4), 383-388. doi:
10.1111/ger.12487

Takahashi K, Murayama H, Tanaka T, Takase M, Suthutvoravut U, Iijima K. (2020). "A qualitative study on thereasons for solitary eating habits of older adults living with family." PLoS One, 15(6), e0234379. doi:
10.1371/journal.pone.0234379

Suthuvoravut U, Takahashi K, Murayama H, Tanaka T, Akishita M, Iijima K. (2020). "Association between
Traditional Japanese Diet Washoku and Sarcopenia in Community-Dwelling Older Adults: Findings from theKashiwa Study." J Nutr Health Aging, 24(3), 282-289. doi: 10.1007/s12603-020-1318-3
COVIDLim WS, Liang CK, Assantachai P, Auyeung TW, Kang L, Lee WJ, Lim JY, Sugimoto K, Akishita M, Chia SL,
Chou MY, Ding YY, Iijima K, Jang HC, Kawashima S, Kim M, Kojima T, Kuzuya M, Lee J, Lee SY, Lee Y, Peng
LN, Wang NY, Wang YW, Won CW, Woo J, Chen LK, Arai H, (2020). "COVID-19 and Older People in Asia:
AWGS Calls to Actions." Geriatr Gerontol Int. doi: 10.1111/ggi.13939
COVID--

Kuzuya M, Aita K, Katayama Y, Katsuya T, Nishikawa M, Hirahara S, Miura H, Yanagawa M, Arai H, Iijima K,
Okochi J, Kozaki K, Yamaguchi Y, Rakugi H, Akishita M, (2020). "The Japan Geriatrics Society Consensus
Statement “Recommendations for older persons to receive the best medical and long-term care during the COVID-19
outbreak—considering the timing of Advance Care Planning implementation." Geriatr Gerontol Int. doi:
10.1111/ggi.14075

Nomura K, Eto M, Ogawa S, Kojima T, Iijima K, Nakamura T, Araki A, Ouchi Y, Akishita M, (2020). "Association
between low muscle mass and metabolic syndrome in elderly Japanese women." PLoS One. doi:
10.1371/journal.pone.0243242
IARU

ALH (Aging, Longevity and Health)Cherbuin N, Iijima K, Kalula S, Malothra R, Rasmussen LJ, Chan A, Lafortune L, Harper S, Zheng X, Lindeman D,(2020). "Societal need for interdisciplinary ageing research. An International Association of Research Universities“Ageing, Longevity, and Health” Stream (IARU-ALH) position statement." BMH journal.

42

AWGS
Liang-Kung Chen, Jean Woo, Tung-Wai Auyeung, Ming-Yueh Chou, Katsuya Iijima, Jae-Young Lim, Li-Ning Peng,
Prasert Assantachai, Hak Chul Jang, Lin Kang, Miji Kim, Sunyoung Kim, Taro Kojima, Masafumi Kuzuya, ChihKuang Liang, Jenny S. W. Lee, Sang Yoon Lee, Wei-Ju Lee, Yunhwan Lee, Wee Shiong Lim, Ken Sugimoto, Tomoki
Tanaka, Chang WW, Minoru Yamada, Zhang T, Masahiro Akishita, Hidenori Arai, (2020). "Asian Working Groupfor Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment." J Am Med Dir Assoc. doi:
10.1016/j.jamda.2019.12.012

Suthutvoravut U, Tanaka T, Takahashi K, Akishita M, Iijima K. (2019). "Living with Family yet Eating Alone is
Associated with Frailty in Community-Dwelling Older Adults: The Kashiwa Study." J Frailty Aging, 8(4), 198-204.
doi: 10.14283/jfa.2019.22

Tanaka T, Takahashi K, Akishita M, Iijima K. (2018). "Can bioelectrical impedance analysis using a home-use device
properly estimate sarcopenia in community-dwelling older adults?" Geriatr Gerontol Int, 18(11), 1579-1580. doi:
10.1111/ggi.13538
4
Tanaka T, Takahashi K, Hirano H, Kikutani T, Watanabe Y, Ohara Y, Furuya H, Tetsuo T, Akishita M, Iijima K.
(2018). "Oral Frailty as a Risk Factor for Physical Frailty and Mortality in Community-Dwelling Elderly." J Gerontol
A Biol Sci Med Sci, 73(12), 1661-1667. doi: 10.1093/gerona/glx225

Tanaka T, Takahashi K, Akishita M, Tsuji T, Iijima K. (2018). "'Yubi-wakka' (finger-ring) test: A practical selfscreening method for sarcopenia, and a predictor of disability and mortality among Japanese community-dwellingolder adults." Geriatr Gerontol Int, 18(2), 224-232. doi: 10.1111/ggi.13163

Shimada H, Lee S, Akishita M, Kozaki K, Iijima K, Nagai K, Ishii S, Tanaka M, Koshiba H, Tanaka T, Toba K,(2018). "Effects of Golf Training on Cognition in Older Adults: A Randomised Controlled Trial." Journal Epidemiol
Community Health. doi: 10.1136/jech-2017-210052

Akishita M, Kozaki K, Iijima K, Tanaka T, Shibasaki K, Ogawa S, Arai H, (2018). "Chapter 1 Definitions anddiagnosis of sarcopenia." Geriatr Gerontol Int. doi: 10.1111/ggi.13311

43

Imaeda S, Son BK, Uchiyama E, Tanaka T, Taniguchi S, Unyaporn S, Miyoshi Y, Tanaka T, Iijima K, Otsuki T.
(2018). “Clarifying Precise Fall Situations Leading to Femoral Fracture through Combined Bedside and Home-Visit
Interviews.” In: AIJ Proceedings of the Housing Studies Symposium 2018, Vol. 13, pp. 65-70.

Imaeda S, Son BK, Uchiyama E, Tanaka T, Taniguchi S, Unyaporn S, Miyoshi Y, Tanaka T, Iijima K, Otsuki T.
(2018). “Investigating Architectural Factors Contributing to the Continuity of Living for the Elderly After Falls andFractures.” In: The 12th International Symposium on Architectural Interchanges in Asia, pp. 420-424.

Ishii S, Tanaka T, Ouchi Y, Akishita M, Iijima K. (2016). "Development of conversion formulae between 4-m, 5-m
and 6-m gait speed." Geriatr Gerontol Int, 15(2), 233-4. doi: 10.1111/ggi.12317

NRST
Htun NC, Ishikawa-Takata K, Kuroda A, Tanaka T, Kikutani T, Obuchi SP, Hirano H, Iijima K, (2016). "Screening
for malnutrition in community dwelling older Japanese: preliminary development and evaluation of the Japanese
Nutritional Risk Screening Tool (NRST)." J Nutr Health Aging. doi:

-

-

-

Ishiki A, Okinaga S, Tomita N, Kawahara R, Tsuji I, Nagatomi R, Taki Y, Takahashi T, Kuzuya M, Morimoto S,
Iijima K, Koseki T, Arai H, Furukawa K, (2016). "Changes in Cognitive Functions in the Elderly Living in Temporary
Housing after the Great East Japan Earthquake." PLoS One. doi: 10.1371/journal.pone.0147025

Ishii S, Chang C, Tanaka T, Kuroda A, Tsuji T, Akishita M, Iijima K, (2016). "The association between Sarcopenic
obesity and depressive symptoms in older Japanese adults." PLoS ONE. doi: 10.1371/journal.pone.0162898

Ishii S, Tanaka T, Akishita M, Iijima K. (2015). "Re: Growing research on sarcopenia in Asia." Geriatr Gerontol Int,
15(2), 238-9. doi: 10.1111/ggi.12304

Seino S, Shinkai S, Iijima K, Obuchi S, Fujiwara Y, Yoshida H, Kawai H, Nishi M, Murayama H, Taniguchi Y,
Amano H, Takahashi R. (2015). "Reference Values and Age Differences in Body Composition of CommunityDwelling Older Japanese Men and Women: A Pooled Analysis of Four Cohort Studies." PLoS One, 10(7), e0131975.
doi: 10.1371/journal.pone.0131975

Ishii S, Tanaka T, Akishita M, Ouchi Y, Tuji T, Iijima K; Kashiwa study investigators. (2014). "Metabolic syndrome,sarcopenia and role of sex and age: cross-sectional analysis of Kashiwa cohort study." PLoS One, 9(11), e112718.
doi: 10.1371/journal.pone.0112718

44

Ishii S, Tanaka T, Shibasaki K, Ouchi Y, Kikutani T, Higashiguchi T, Obuchi SP, Ishikawa-Takata K, Hirano H,
Kawai H, Tsuji T, Iijima K. (2014). "Development of a simple screening test for sarcopenia in older adults." Geriatr
Gerontol Int, 14(Suppl 1), 93-101. doi: 10.1111/ggi.12197

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45

Institute of Gerontology (IOG)
Gerontology

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