IRT2024
PL: Plenary lecture, IL: Invited lecture, OP: Oral presentationTime
Day 1 (Sep. 3)
9:00Registration, Coffee, Tea
10:00-10:20 Welcome address (VIP Welcome)Session 1 (Chair: Piet Herdewijn)
10:25-10:50 IL1 – Mano Manoharan, Alnylam Pharmaceuticals
10:55-11:20

Biomimetic Chemistry of RNA Therapeutics
IL2 – Satoshi Ichikawa, Hokkaido University

Discovery of antibacterial drug lead based on nucleoside natural products
Session 2 (Chair: Jean-Jacques Vasseur, Co-chair: Piet Herdewijn)
11:25-12:15 PL1 – Imbach-Townsend Award Lecture – Peter Nielsen, University of Copenhagen
A precision antisense peptide nucleic acid antibiotics platform for fighting infections
12:15-13:45

by multidrug-resistant Gram-negative bacteria
Lunch,

Posters I
Session 3 (Chair: Noriaki Minakawa)
13:45-14:10 IL3 – Meena, Stoke Therapeutics
Utilization of a Pharmacokinetic (PK) Model for STK-001 (ASO) in Patients with
14:15-14:30

Dravet Syndrome (DS) To Support the Selection of Dosing Regimens in Clinic
OP1 – James D. Thorpe, McGill University

14:35-15:00

Sustainable Methods for Oligonucleotide Synthesis
IL4 – Christian Ducho, Saarland University

15:05-15:30

New adventures in oligonucleotide modifications
IL5 – Kurt V. Gothelf, Aarhus University

Modification of oligonucleotides at phosphorus
15:30-16:00 Coffee, tea
Session 4 (Chair: Akimitsu Okamoto)
16:00-16:15 OP2 – Platinum Sponsor talk: ChemGenes, Yann Thrillier
Thiophosphoramidate Morpholino Oligonucleotides (TMOs): A Novel Class of PMOs
16:20-16:30

Compatible with Conventional Automated Oligonucleotide Synthesis
OP3 – Platinum Sponsor talk: AM Chemicals, Andrei P. Guzaev

16:35-17:00

TRIDENT – a novel universal solid support for oligonucleotide synthesis
IL6 – Marçal Pastor-Anglada, University of Barcelona

17:05-17:30

Membrane transporters for natural nucleosides and nucleoside- derived drugs
IL7 – Chandra Vargeese, Wave Life Sciences
Base, sugar, and backbone modifications of stereopure oligonucleotides to improve

17:40-18:10
19:30

pharmacology across modalities
Chu Awards
Welcome reception at Asakusa view hotel

IRT2024
TimeDay 2 (Sep. 4)

Session 5 (Chair: Jean-Jacques Vasseur, Co-chair: Kathie Seley-Radtke)
9:00-9:30
PL2 – Montgomery Award Lecture – Eiko Ohtsuka, AIST
Studies on nucleic acids syntheses
Session 6 (Chair: Kathie Seley-Radtke)
9:35-9:50
OP4 – Malgorzata Honcharenko, Karolinska Institutet
A Novel Approach for Synthesizing Oligonucleotide Multi-Conjugates Using
Combined: SPAAC and IEDDA Click Chemistries
9:55-10:10
OP5 – Suzanne Peyrottes, University of Montpellier, CNRS
Carbo- and acyclonucleoside phosphonate analogues as novel chemotypes for
Plasmodium falciparum inhibition
10:15-10:30 OP6 – Robert Britton, Simon Fraser University
A Rapid, Flexible and Scalable Synthesis of Nucleoside Analogues
10:30-10:55 Coffee, tea
Session 7 (Chair: Hiroyuki Asanuma)
10:55-11:20 IL8 – Serge Van Calenbergh, Ghent University
Tubercidin analogues outsmart protozoan pathogens responsible for important human and livestock diseases
11:25-11:40 OP7 – Nicholas Chim, University of California, Irvine
Structural insights into the most efficient TNA polymerase Structural insights into themost efficient TNA polymerase
11:45-12:00 OP8 – Michal Hocek, the Czech Academy of Sciences
Enzymatic Synthesis of Base-Modified RNA with Engineered DNA Polymerases
12:00-13:30 Lunch,
Posters II
Session 8 (Chair: Fumi Nagatsugi)
13:30-13:55 IL9 – Roger Strömberg, Karolinska Institutet
Artificial RNases based on modified oligonucleotides
14:00-14:15 OP9 – Dong Wang, University of California, San Diego
Structural Basis of Transcription Recognition of Expanded Genetic Alphabet by Cellular RNA Polymerases
14:20-14:35 OP10 – Michiko Kimoto, Xenolis Pte. Ltd.
Six-Letter DNA Aptamer Generation as an Antibody Alternative
14:40-16:00 Coffee, tea
Recruitment/Discussion session
Session 9 (Chair: Ramon Eritja)
16:00-16:25 IL10 – Kazuo Nagasawa, Tokyo University of Agriculture and Technology
Control of functions of dynamically formed high-order nucleic acids by polyoxazole
compounds
16:30-16:45 OP11 – M. Carmen Galan, University of Bristol
Small molecule G-quadruplex ligands are antibacterial candidates for Gram- negative bacteria
16:50-17:05 OP12 – Shigeori Takenaka, Kyushu Institute of Technology
Double-strand structuring of oligo-thymine by cyclic bis-naphthalene diimide
Session 10 (Chair: Takehiko Wada)
17:10-17:25 OP13 – Vyacheslav V. Filichev, Massey University
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
17:30-17:55 IL11 – Zlatko Janeba, IOCB Prague
Inhibitors of enzymes of the purine salvage pathway

IRT2024
Time

Day 3 (Sep. 5)

Session 11
09:00-09:45 PL3 – Ikehara Award (JSNAC award) – TBD
Session 12 (Chair: Hidetaka Torigoe)
09:50-10:15 IL12 – Tigran Chalikian, University of Toronto
10:20-10:35

Conformational Propensities of Double-stranded G- and C-rich DNA Domains
OP14 – Claudia Sissi, University of Padova

Non-canonical nucleic acids arrangements for targeted therapies
10:35-11:00 Coffee, tea
Session 13 (Chair: Hisae Tateishi-Karimata)
11:00-11:15 OP15 – Chun Kit Kwok, City University of Hong Kong
11:20-11:45

Mapping and targeting of RNA G-quadruplex structures
IL13 – Yan Xu, University of Miyazaki

11:50-12:15

In Cell 19F NMR for Non-Canonical Structures
IL14 – Janez Plavec, Slovenian NMR Centre at the National Institute of Chemistry

12:15-13:45

NMR illuminating the dynamics of DNA structural features
Lunch,

14:00-18:00
18:00

Posters III
Tour
Symposium Dinner at Hotel Conrad Tokyo

IRT2024
Time

Day 4 (Sep. 6)

Session 14 (Chair: Elzbieta Kierzek)
09:00-09:25 IL15 – Sara N. Richter, University of Padova
Non-canonical nucleic acid structures in the XDP neurodegenerative disease nucle09:30-09:55

ic acids
IL16 – Katrin Paeschke, University Hospital Bonn
Viral hijacking of hnRNPH1 unveils a G-quadruplex driven mechanism of stress

10:00-10:25

control
IL17 – Kyeong Kyu Kim, Sungkyunkwan University

Noncanonical nucleic acids: structure, function and modulation
10:25-10:55 Coffee, tea
Session 15 (Chair: Asako Yamayoshi)
10:55-11:20 IL18 – Daniela Montesarchio, University of Napoli Federico II
11:25-11:50

Non-canonical DNA-based aptamers for therapeutic applications
IL19 – Xiaogang Qu, Changchun Institute of Applied Chemistry

11:55-12:10

Targeting Non-Canonical Nucleic Acids Structures and Their Applications
OP16 – Mélanie Etheve-Quelquejeu, Université Paris Cité, CNRS

12:10-13:40

Synthesis of Bisubstrate Analogues for m6A RNA Methylation Studies
Lunch,

Posters IV
Session 16 (Chair: Chris Meier)
13:40-13:55 OP17 – Anna M. Kietrys, Carnegie Mellon University
14:00-14:15

Circular RNAs: an underdog of diagnostics and therapy
OP18 – Yusuke Takezawa, The University of Tokyo
Strategic design of metal-responsive allosteric DNAzymes utilizing 5-modified uracil

14:20-14:35

nucleobases as metal recognition sites
OP19 – Takumi Okuda, University of Würzburg
SAMURI: SAM analogue utilizing ribozyme for site-specific RNA click tag incorpora-

14:40-15:05

tion
IL20 – Jory Lietard, University of Vienna

DNA, RNA and XNA microarrays: high-throughput oligonucleotide chemistry
15:05-15:30 Coffee, tea
Session 17 (Chair: Toshihiro Ihara)
15:30-15:55 IL21 – Chaoyong Yang, Xiamen University
16:00-16:15

Dendrimeric DNA Coordinate Barcoding Design for Spatial RNA Sequencing
OP20 – Yohei Yokobayashi, Okinawa Institute of Science and Technology

16:20-16:45

Controlling RNA function in mammalian cells by small molecules
IL22 – Damien Baigl, Ecole Normale Superieure

16:50-17:20
17:20-17:45
17:45

DNA-encoded synthetic systems with life-like properties
Poster awards
Announcements, presentation of next IRT and ISNAC
Closing Remarks

＊Please see abstract for co-author information.

Day 1: Sep. 3 (Tue) 12:20 – 13:40
Yoanes Maria Vianney University of Greifswald
Ligand- and pH-induced topological transitions of aP001 quadruplex- duplex hybrid: implications for a molecularswitchTina-Thien Ho University of Southampton
tumour cell killing with novel
P002 Selective
antibody-conjugate using self-assembling DNA
nanostructures
Yogesh S. Sanghvi Rasayan Inc.
Development of nucleobase-functionalized molecules forP003 self-assembling hydrogels: Potential applications incontrolled drug release
Danyang Ji City University of Hong Kong
Stem-Loop Structure Library Expedites
P004 Pre-Defined
Discovery of L-RNA Aptamer that Targets RNA
G-quadruplex
Sebastian Häcker Karlsruher Institut für Technologie (KIT)P005 Probing of DNA photochemistry with C-nucleosides as
photosensitizer
Andreas Schmidt Karlsruhe Institute of Technology (KIT)
P006 Sequence specific synthesis of DNA-chromophorearchitectures as light harvesting systems
Andrea Criscuolo University of Naples Federico II
P007 Tailoring covalent dimers for the optimization ofanti-HMGB1 G-quadruplex-forming aptamers
Vanessa Hanff
Goethe University Frankfurt am Main
P008 Visible light-activatable Q-dye molecular beacons forlong-term mRNA monitoring in neurons
Lessandro De Paepe Ghent University
P009 Templated and Sequence-Selective Pre-miRNA
G-Quadruplex Targeting
Jan H. Meffert
Ghent University
P010 Multi-Functionalization of Amine-Oligonucleotides using
5HP2Os for Stable and Versatile Bioconjugation
Mria Chowdhury The University of Western Ontario
P011 Massive red-shifted intrinsically fluorescent nucleobase
molecular rotors
Prince Salvador

University of California, Davis

P012 Harnessing ADAR Therapeutic Potential: Cellular Repairof MeCP2 Mutation Linked to Rett Syndrome with a Fully
Sugar Modified Guide RNA
Nazarii Sabat

Institut Pasteur

P013 Next-generation chemoenzymatic synthesis ofchemically modified oligonucleotides

P014

Tomasz Czapik Karolinska Institutet
Special delivery: small molecules conjugatesChristopher Wilds Concordia University
pyrimidine modified arabino‐and
P015 C5‐Propynyl
2'‐fluoroarabino nucleic acids enhance RNA binding
and are RNase H competent

Odd number 12:20-13:00
Even number 13:00-13:40
P016

Renata Kasprzyk University of Konstanz
Cell-permeable nicotinamide adenine dinucleotides for
exploration of cellular protein ADP-ribosylation

P017

So Muramoto Osaka University
Synthesis of peptide oligonucleotide conjugates basedon the condensation of a lysine side-chain and athioester

P018

Sandra Smieszek Vanda Pharmaceuticals
Efficacy and Safety of a Novel ASO Targeting
IGHMBP2 Cryptic Splice Variant for the Treatment of
CMT2S

P019

Shun-Ching Wang National Chung Hsing University
Structural basis for water modulating RNA duplex
formation in the CUG repeats of myotonic dystrophy
type 1

P020

Shih-Chun Huang National Chung Hsing University
Targeting junction sites in different DNA by
bis-intercalators induces topological changes withpotent antitumor effects

P021

Virginia Chiu Ontario Tech University
Investigating Chemically-Modified Short Activating
RNAs to Increase Nuclease Stability and Gene
Activation

P022

Soshu Yasuda The University of Tokyo
Development of novel epigenetics drug based on
nucleic acid therapeutics

P023

Ajaya Ram Shrestha Luxna biotech Co.,Ltd.
Promising protecting group for N(tert-butyl)guanidine-bridgednucleic acid, GuNA™[tBu]to ease its application in antisense oligonucleotides

P024

Jiro Kondo Sophia University
Educational tools for learning the three-dimensional
structure of nucleic acids

P025

Julia Dietzsch
University of Wuerzburg
Orthogonal fluorescence activation of small
chromophores by DNA, RNA and proteins

P026

Takashi Osawa Osaka University
Synthesis of oligonucleotides containing an S-methyl
thioimidate-bridged nucleic acid (Me-TIBNA) that control their ability
to form duplexes in response to pH and complementary strand
Akari Endo

Chiba Institute of Technologyof binding activity of an aptamer that binds
P027 Improvement
to IgG1 by chemical modification and in silico analysis
of dynamics of the aptamer

P028

Kazuyuki Kumagai Chiba Institute of Technology
The RNA aptamers against the VβBCC complex
Kun Chen

Konan University

P029 Quantitative analysis of i-motif and G-quadruplex

structures on CDH1 gene under pH and K+ variations

P030

Lutan Liu Konan University
Elucidating the Role of Groove Hydration on Stability
and Functions of Biased DNA Duplexes in Cell-Like
Chemical Environments

IRT2024

Yuta Chikada Kyushu University
P031 Synthesis of Nucleotide Derivatives of Cdap for theSpecific Recognition of 8-oxo-dG in DNA

Masato Sugawara Aoyama Gukuin University
reactive tags into phosphate backbone to
P046 Installing
regulate the duplex formation on the bead toward
multiplex biomolecular detection

Masahiro Wakano The University of Tokyo
P032 Reversible optical control of receptor activity by anoligonucleotide based agonist carrying azobenzene

Katarzyna Frankowska Centre of New Technologies
University of Warsaw
P047 Chemical circularization of full-length mRNA performedby periodate oxidation and reductive amination

Juki Nakao Nagasaki University
Development of Photo-reactive Oligonucleotides with
P033 Novel Psoralen N-hydroxysuccinimides for Gemone
Editing Tools

P048

Kerstin Müller Karlsruhe Institute of Technology
P034
Sydnone-based turn-on fluorogenic probes

Jamila A. Osman NIHS
P049 Synthesis of interstrand crosslinked nucleic acids using
2’ -deoxythioguanosine-functionalized oligonucleotides

Nazmie Kalisi University of Southern DenmarkP035 Programmable RNA Loading of Extracellular Vesicles
with Toehold-Release Purification

Rikuto Maruyama Osaka Universityof controlling duplex-forming ability toward theP050 IImpact
target RNA strand on the RNA cleavage activity
of 8–17 DNAzyme

Ryosuke Nagasawa Tohoku Univ.
P036 Large-scale analysis of RNA-binding selectivity of asmall molecule utilizing structured RNA libraries

P051 Lipid-stapled Oligonucleotide Supramolecular

Kazuki Kuwahara Tohoku University
P037 Formation of pseudorotaxane and catenane bychemically cyclizedoligo DNAs

Patricia Korczak INSERM
oligonucleotide synthesis on automated ÄKTAP052 The
oligopilot synthesizer at the ARNA Laboratory and their
purification process

Minako Narita The University of Tokyo

P038 Nano-assembled structures and cellular delivery offluorocarbon–DNA conjugates

Stefan Vogel University of Southern Denmark
Programmable mRNA Loading of Extracellular Vesicles

Faith Kivunga

INSERM

Structures: Baits for Anticancer Therapeutic Application

Reiko Iwase

Teikyo University of Science

property of 2’ -O-methyl RNA containing
P053 Fluorescentamide-linked uridine dimer modified with pyrene on
hybridization with RNA

Glenn A. Burley University of Strathclyde

Kento Miyaji

Tokyo Institute of Technology

and functional profiling of abasic sites:
P039 Structure
platform for the development of pivot-based therapeutic

P054 Synthesis and properties of prodrug-type

Kentaro Kobata Kyoto Institute of Technology
P040 Photo-cross-linking oligonucleotides as a telomerase
inhibitor

Zumila Hailili Japan Advanced Institute of Science and Technology
chemical genomic manipulation:
P055 Towards
photochemical double- duplex invasion using ultra-fast
photo-cross-linker

oligodeoxynucleotides activated by β-galactosidase

oligonucleotides

Koki Takeda Kyoto Institute of Technology

P041 Synthesis and evaluation of diazirine-tethering ODNs forselective photo-cross-linking with mutated RNAs
Tatsuya Ozasa

Aoyama Gakuin University

P042 Preparation of oligodeoxynucleotides bearing azide
methyl group and their application

Chisa Takemori Tokushima Bunri University

P056

Jennifer Frommer University of Oxford
Flexizyme-mediated DNA labelling
Mizuki Tada

Nagoya university

P057 Evaluation of the structure-activity relationship ofminimal mRNA

Philip K. Wagner

University of Cologne

P043 Synthesis and properties of oligonucleotides containing

P058 Exploring Unnatural Nucleic Acids for Enhanced

Yuta Ito Tokushima Bunri Universityof oligonucleotides containing
P044 Synthesis
5-heteroarylpyrimidine bases by post-synthetic
trifluoromethyl conversion and their fluorescence properties

P059 Exploration of RNA aptamers against photoreceptor

Arya Das Technical University of Munich
on-array mapping of off-target
P045 Ultra-large-scalecleavage of chemically-modified crRNA in Cas9 andCas12aP060 Re-pairing DNA: binding of a ruthenium phi complex to a2'-C,4'-C-methylene-bridged thymidine

Biomolecular Labeling
Zimu Zhang

Tokyo Institute of Technology

protein DrBphP

Tayler D. Prieto Otoya
double mismatch

University of ReadingDay 2: Sep. 4(Wed) 12:05 – 13:25＊Please see abstract for co-author information.

Odd number 12:05-12:45
Even number 12:45-13:25

Yuka Kataoka Nihon University
Investigation of RNA imaging using the signal
P061 amplification by ternary initiation complexes system incellMichelle Vogts University of Hamburgof a targeted HILIC-MRM Method for theP076 Development
Quantification of TriPPPro Prodrugs and their
Metabolites in complex Mixtures

Tatsuya Nishihiara Aoyama Gakuin University
Intensity-changing fluorescent barcode beads for theP062 multiplex biomolecular analysis using the artificial
oligodeoxynucleotide sensor

Elzbieta Kierzek Institute of Bioorganic Chemistry
Polish Academy of Sciences
P077 In cellulo and in virio secondary structure of vRNA of
influenza A virus

Yuho Abe Nihon University
P063 Design of novel acyclic ESF nucleosides for DNA
sequence analysis

Eriks Rozners Binghamton University
P078 Amide modifications improve on-target specificity ofsiRNAsMark M. Somoza Leibniz Institute for Food Systems Biology
open‐source advanced maskless synthesizer forP064 Anlight‐directed chemical synthesis of large nucleic acidlibraries and microarrays

P079 Catalytic RNAs and their role in an RNA-peptide-world

Yusuke Fujiwara Osaka University
P065 Photoswitchable RNA binding ligands affected the RNA
foci formation and the associated RNA binding proteins

Randall Ouye University of California, Davis
P080 Effect of various Phosphoramidate internucleotidic
linkages in guide Oligos on ADAR deamination rate

Yoshiaki Masaki Tokyo Institute of Technology
P066 Quantification of non-canonical nucleotides by
next-generation sequencing

P081 Repurposing ADARs for DNA Base Editing

Katarzyna Grab

University of Warsaw

P067 Fluorescent RNAs as molecular probes for monitoring
the activity of decapping enzymes

Van Hai Nguyen University of Warsaw

Kathrin Halter LMU München

Jeff Cheng University of California, Davis

Yunsong Xu

The University of Tokyo

P082 Simultaneous detection of multiple miRNAs in cells

through self- assembling on-off fluorescent DNA probes
Yoshiyuki Tanaka

Tokushima Bunri University

P068 Synthesis of novel mRNA 5’ cap analogues for improving

P083 Crystallographically captured reactive intermediate ofVictorio Jauregui-Matos University of California, Davis
Regulation of RNA Editing with
P069 Site-SpecificRibose-Modified Nucleoside Analogs in ADAR Guide
Strands

John C. Chaput University of California, Irvine
Evolution as a Generalizable Approach toP084 Chemical
Improving the Activity of RNA-cleaving DNAzymes in
Cells

mRNA-based therapeutics

Halle M. Barber McGill University

the enzymatic reaction of an hOGG1 mutant

Carlos González

CSIC

P070 Fluorine-Modified Antisense Oligonucleotides Targeting

P085 Structure and dynamics of i-DNA and its junctions withKaleena Basran McGill University
P071 Exploring the Potential Applications of Click Chemistryon siRNATomasz Spiewla University of Warsaw
MST-based assay reveals new binding preferences
P086 Anof IFIT1 for canonically and non-canonically cappedRNAs

the C9orf72 Repeat Expansion in C9FTD/ALS

Iram M. Ahmad University of Iceland

B-DNA

Shuntaro Takahashi

Konan University

P072 Non-covalent spin-labeling of RNA through helicalP087 Twisting of helicity induces diverse functionality of

Raahul Sriram Carnegie Mellon University
P073 NAs as disrupters o biomolecular condensates
associated with Amyotrophic Lateral Sclerosis

Tadashi Umemoto Luxna Biotech Co. Ltd.
o -cyclopropylene deoxyribonucleic acidP088 Application-Cin siRNA to reduce phosphorothioate bonds
while maintaining potency and stability

Keisuke Fukunaga Tokyo Institute of Technology
P074 Development of small molecule- and protein-responsivecell-free riboswitches

Tamaki Endoh Konan University
P089 Interactions between fluorogens and i-motif DNAs
depending on loop sequences

Eliza Filipiak Karolinska Institutet
P075 Enhancing the delivery of oligonucleotide therapeutics
for Duchenne Muscular Dystrophy

Sinjan Das Konan University
P090 ATP-mediated regulation of stability and function ofi-motif DNA

stacking

i-motif DNA

IRT2024

Kaifeng Zhao McGill University
P091 Determining Spatial Distribution of DNA Secondary
Structures in Living Cells

Aina Fujiwara Chiba Institute of Technology
between a small molecule, ANP77, andP106 Interaction
double stranded DNAs with the T/CC and C/CC internal
loops

Kosuke Tsuzuki Toholu University
P092 Exploration of small molecule-RNA pairs that bindthrough complementary hydrogen bonds

Ayano Tabira Tokyo Institute of Technology
P107 Effects of single mismatch on RNase H-mediatedcleavage

Kazumitsu Onizuka Tohoku University
P093 Large-scale analysis of RNA alkylations using
multiplexed RNA structure libraries

Jack Barr Ghent University
Light-triggered stapling of biologically relevant DNA
P108 tetraplexes increases topological, thermodynamic andmetabolic stability

Yoshiya Ikawa
University of Toyama
Biochemical characterization of a trans-acting VS
P094 ribozyme and its substrate pair designed to be
applicable to in droplet laboratory evolution experiments

P109

Yuuhei Yamano Tohoku university
P095 Analysis of abasic site generation in DNA byphoto-catalytic reaction

Leo Toutatsu Liu The University of British Columbia
the sequence and chemical space ofP110 Expanding
enzymatically synthesized oligodeoxynucleotide utilizing
dimeric building blocks

Sunipa Sarkar

Konan University

P096 Gene regulatory mechanisms of imperfectG-quadruplexes with bulges
Tomoki Sakamoto

Andrea Taladriz-Sender University of Strathclyde
Chemical Tools for unraveling RNA splicing

Hiromu Kashida

Nagoya University

P111 Color-Changing Fluorescent Barcode for Multiplexed
Labeling of biomolecules

Kyoto University

Jussara Amato University of Naples Federico II

P097 Molecular Crowding Effects on Base Pair Dynamics andP112 Insights into the recognition of G-quadruplex nucleic

Shin ANDO Sophia University
P098 X-ray Crystallography of Nucleic Acids by theCounter-diffusion Method in a Microgravity Environment

Ayako Kurimoto Protein Metrics, LLC
Optimization of a Liquid Chromatography-Tandem Mass
P113 Spectrometry (LC-MS/MS) Based Workflow for mRNA
Oligonucleotide Sequence Mapping

Stability in DNA Triplex Structures

Mizuki Fujimotoacid structures by the KHSRP protein

Tokushima Bunri University

Emi Miyashita

Kyoto University

P099 Catalytic roles of the active residues in an hOGG1

P114 BIVID-MaP identifies variant-specific interaction

Tomoka Akita Konan University
P100 Stability and structural analysis of DNA/RNA
heteroduplexes containing a bulge

Soumitra Pathak National Institute for Materials Science (NIMS)
dependent cellular uptake of G-quadruplex
P115 Topology
scaffolded CpG oligodeoxynucleotides and theirimmunostimulatory effects

Krista Urup University of Southern Denmark
P101 Double-Headed Nucleotides in G-quadruplexes: Double
Trouble or Reduced Electrostatic Strain?

Minami Kato Nagoya University
P116 Generation of novel circular mRNA using
G-quadruplexes

double mutant

Hidetaka Torigoe

Tokyo University of Science

P102 Specific binding of copper ion to mismatched base pair
involving 5-fluorouracil in duplex DNA
Wenjue Fan

Tohoku University

P103 Study on base pairing and polymerase recognition of

the unnatural alkynylated purine-pyridazine base pairs
Asako Murata

Mitsuharu Ooga Graduate School of Science Kyoto University

P117 Sequence-specific recognition of G-quadruplex
structures with dual DNA-binding conjugatesPhilippe Junglibrary and RNA-Seq

Konan University

P105 Phase separation of G-quadruplex regulated by
epigenetic modification

RWTH Aachen University

P118 Dissipative Orchestration of a DNA-Based Cascade forControlled Biocatalysis

Kyushu University

of RNA motifs for small-molecule binding
P104 Identification
using a combined method of Dicer cleavage of an RNA
Mitsuki Tsuruta

between small-molecule and RNA structure

P119

Gurudas Chakraborty DWI-Leibniz Institute for Interactive Materials
Formation of i-Motif Structure in Organic Solvents
Matthias Thijs

McGill University

Oligonucleotides: New Methodology Enables
P120 Hydrazine
Versatile Hydrazone Conjugation in Water and Organic
Solvents

Day 3: Sep. 5 (Thu) 12:20 – 13:40＊Please see abstract for co-author information.

Odd number 12:20-13:00
Even number 13:00-13:40

Shigeyoshi Matsumura University of Toyama
P121 Experimental evolution of a trans RNA‐cleaving
ribozyme using droplet screening integrated devices

Atanu Ghosh Indian Association for the Cultivation of
Science A P(III) Platform for the Synthesis of Antisense
P136 Morpholino Oligonucleotides in an Automated DNA
Synthesizer

Luigi A. Agrofoglio University of Orleans
Innovative Lyotropic Liquid Crystalline Emulsions ofP122 LAVR-289, a Highly Lipophilic Antiviral: Internal
Mesophase Impact on the Biological Activity

P137 Photoreactive uridine analogs for nucleic acidYudai Yamaoki Kyoto University
P123 In-cell NMR study on structure, dynamics, and ligand
interactions of nucleic acids in living human cells

P138 Targeting the IRES structure of mRNA for modulating

Yuichiro Aiba Nagoya University
Parallel-stranded peptide nucleic acids for specificP124 recognition of double-stranded DNA and their structural
analysis

Enrico Cadoni Ghent University
Tetraplexed Nucleic Acid Structures as Templating
P139 Platform for Proximity-enhanced Photochemical
Reactions

Hiroshi Abe Nagoya University
P125 Chemistry-based mRNA design for efficient translation

Agnieszka Dziergowska Lodz University ofTechnology
P140 New approach to the site-specific modification of RNA
fragments with f5U/ f5C

Tatsuyuki Yoshii

The University of Tokyo

Hermann Neitz

University Würzburg

crosslinking

Albert Ferriol Monjo

University of Southampton

gene translation

Zhen Xi

Nankai University

P126 Engineering RNA and RNA-binding protein forP141 Genome Therapy: A New Approach for Tumor Growth

I-Ren Lee National Taiwan Normal University
P127 Slippage Dynamics of Trinucleotide Repeat Sequences
Studied by Single-molecule FRET Spectroscopy

P142 Enlightening RNA biology - Insights from Fluorescentmammalian synthetic biology tool

Eylon Yavin

Hebrew University of Jerusalem

Inhibition

Pauline Pfeiffer

Chalmers University of Technology

Nucleobase Analogues
Svenja Hehn

Universität Konstanz

P128 Challenges in the detection of BRAF V600E mutation

P143 Engineering DNA-dependent RNA Polymerases

Amer Fadila Hebrew University of Jerusalem
Generation of FIT-PNAs: Cyclopentane backbone
P129 New
modifications of surrogate base for improved RNA
sensing

Sahra Tajdar University of Hamburg
Synthesis and Optimization of potential Inhibitors that
P144 target the ADPR-binding Macrodomain Mac1 of
SARS-CoV-2

Masayuki Sakurai Tokyo University of Science
ICLAMP: a novel technique to explore adenosine
P130 deamination via inosine chemical labeling and affinity
molecular purification

efficiency of ADAR-mediated RNA editing via
P145 Improving
guide strand modifications probing dsRBD-RNA

Chaofan Zheng Kyushu university
P131 Investigation of the effect of a small molecule inupregulating the expression of a microRNA cluster

Yuhei Takahashi Tokyo University of Science
and Convergent Synthesis of
P146 Solution-Phase
Boranophosphate DNAs by an H-boranophosphonate
Methodusing FIT-PNAs

Poonam Upadhyay

Indian Institute of Technology

P132 Bombay
Error-free replication across N2- biphenyl-dG DNA

Adducts by uman Translesion ynthesis olymerase
Nina Allen

University of Bristol

P133 Fishing for G-quadruplexes with Photo-Crosslinking
ProbesFabienne Levi-Acobas

Pasteur Institute

P134 Exploring the capacity of Human polymerase q to
produce chemically modified oligonucleotides

Yan Badji UPC Université Paris citéof modified aptamers to study the catalytic
P135 SELEX
mechanism underlying peptidoglycan polymerization bytranspeptidase

Towards the Acceptance of Modified Nucleotides

Kristen Campbell

University of California - Davisinteractions

Ryuichi Inutake

Tokyo University of Science

P147 Stereocontrolled synthesis of phosphorodiamidate
morpholino oligomer
Simone Rosinus

Saarland University

P148 Lipophilically functionalized analogs of muraymycin
nucleoside antibiotics
Tyler J. Rutherford

Concordia University

and Characterization of DNA Tetrahedra Containing
P149 Synthesis
O6- Alkylene 2’ -Deoxyguanosine Cross-Links for Controlled
Disassembly Triggered by a DNA Repair Protein
Erika Schaudy

University of Vienna

P150 dNTPs with photosensitive protecting group: Towards
light-directed enzymatic oligonucleotide synthesis

IRT2024

Hisae Tateishi-Karimata Konan University
Quantify specific interactions determining G-quadruplex
P151 function during cancer progression using a
pseudo-cellular system
Takehiko Wada

Tohoku University

Construction of Chimeric Artificial Nucleic Acids (CANA) for
P152 the treatment of pancreatic cancer by inhibition of thetranscription factor BACH1 IV: Establishment of a molecular
design strategy based on in vitro and in vivo analysis

Felix Marschall

Saarland University

P166 Small Molecule-Oligonucleotide Conjugates with
Therapeutic Potential Against Breast Cancer

Qingwen Chen SANKEN, Osaka Univ.
P167 Artificial intelligence leading to a cost-effective screeningof small molecules targeting nucleic acids

Kiyoshi Kakuta Tokyo University of Science
Synthesis of Oligodeoxynucleotides Using
P153 Solid-Phase
Nucleobase N-Unprotected Oxazaphospholidine
Derivatives Bearing a Long Alkyl Chain

P168 Advances in RNA labeling with trifluoromethyl groups

Ettore Napolitano University of Naples Federico II
and optimization of anti-HMGB1
P154 Discovery
G-quadruplex-forming aptamers as potential anticancer
therapeutics

P169 Synthesis and properties of xanthosine containing RNA

Aya Koshizuka Sophia University
does the number of bases in loops of G-rich
P155 How
repeats affect the formation of G-quadruplexes and theirstability?

P170 Toward fluorophores for photocross-linking to

Surachada Chuaychob Kyoto University
P156 Extracellular Mimicking of CUG Repeat RNA and
MBNL1 Aggregate

Seojung Cho The University of Tokyo
A novel strategy to improve in vivo behavior of DNA
P171 aptamers based on the modification withimmune-evading polymers

Peng Lin

Kyoto University

P157 Design of DNA-based artificial compartments for
implementing metabolic pathways
Shu Ohno

Osaka University

Clemens Eichler

Anna Rázková

University of Innsbruck

University of InnsbruckPrzemyslaw Wanat

University of Innsbruckfluorescent light‐up aptamers

Tomotaka Kumagai

Kyoto University

P172 Evaluation of Enzymatic Incorporation with FluorescentThymidine Nucleotide Analogues
Yukiko Kamiya

Kobe Pharmaceutical University

P158 Application of dynamical FMO calculation to small

P173 Design of anti-miR-21 oligonucleotide composed of SNA

Santra Santhosh Leibniz Institute for Food Systems
at TUM Freising, Germany
P159 Biology
Optimizing Sequence Fidelity in DNA Microarray
Synthesis Through Depurination Reduction Strategies

Shuhei Miyakawa Osaka University
Investigation of the dynamic interactions between
P174 SARS-CoV-2 RNA-dependent RNA polymerase andRemdesivir through fragment molecular orbital calculations

molecule drug discovery targeting bulged RNA

Ilaria Frasson

University of Padova

P160 The Dynamic Interplay of G-quadruplexes and i-Motifs in
HSV-1 Promoter Regulation in infected cells
Tomoki Yoshimura

Osaka University

synthetic route for 1'-C,3'-O-propylene-bridged
P161 Novelaltritol nucleic acid phosphoramidites bearing adenine
nucleobase

Hidenori Okamura

Tohoku University

P162 N⁶-guest modified adenosines enable reversible controlof gene expression via host-guest interaction
Masahito Inagaki

Nagoya University

analogs with a hydrophobic photocleavable tag
P163 Cap
enable facile purification of fully capped mRNA withvarious cap structure
Yujun Zhou

Gifu University

and antisense activity of LNA gapmers
P164 Synthesis
containing 4’ -C-aminoetoxy-2’ -O-methyl modified
nucleoside analogs
Maryke Fehlau

BioNukleo GmbHP165 Efficient enzymatic synthesis routes for natural andmodified nucleosides and nucleotides

and artificial nucleobases

Yaoyao DUTokyo institute of technology

P175 Removing barriers in the photooxidation of DNA bybiphenyl photosensitizer-PNA conjugates
Yurina Shimada

Gifu University

P176 Development of DDS-free All-PS modified siRNAs withcholesterol molecules
Attila Palágyi

IOCB Prague

P177 Enzymatic Synthesis of Hypermodified DNA with
Expanded Genetic Alphabet
Odai Bsoul

Bar-Ilan University

P178 N1 Hyantoinyl-ribose as a Novel Uridine Mime6c.
Synthesis and Characteriza6on
Anna Heib

Saarland University

P179 Towards Lipophilic Prodrugs of Antisense
Oligonucleotides

Day 4: Sep. 6(Fri) 12:15 – 13:35
Yuyuan Chen The University of Tokyo
P180 A pH-Responsive Nucleobase-Modified DNA Aptamer
for Selective Inhibition of Cancer Migration
Malgorzata Wasinska-Kalwa

Centre of New

P181 Technologies University of Warsaw Cap-mediatedtranslation of circular mRNA
Marcin Warminski

University of Warsaw

P182 Development of novel trinucleotide mRNA 5' end analogs
for therapeutic applications and functional studies
Attila Tortorella

Scuola Superiore Meridionale

P183 Unraveling the physicochemical interplay between
G-Quadruplex structures and model membranes＊Please see abstract for co-author information.

Odd number 12:15-12:55
Even number 12:55-13:35
Grazyna Leszczynska

Institute of Organic Chemistry,Lodz University of Technology

P195 New strategies of post-synthetic RNA modification as aconvenient method for installation of troublesome modified groups

Monta Nakamura

Tokyo university of science

P196 Stereoselective synthesis of nucleotide analog prodrugs(ProTides) by an oxazaphospholidine method
Sarah Krukenberg

University of Hamburg

P197 Synthesis of different MASTER-NAADP derivatives of
the Ca2+ mobilizing second messenger NAADP
Paul Theodore Ludford III

Trilink Biotechnologies

P198 Exploration, Modification, and Generation of New
CleanCap® analogues for mRNA Therapeutics

Institute of Bioorganic Chemistry
Polish Academy of Sciences

Marta Rachwalak

Concetta Giancola University of Naples Federico II
P184 Physicochemical study of DNA G-quadruplex stability
and energetics of interaction with protein and drugs

P199 How much more can we get out of dimethoxytrityl chloride? New

Yo Yano PeptiStar Inc.
P185 Application of Continuous Chromatography Method to
Oligonucleotide Purification

Robert H.E. Hudson The University of Western Ontario
Imidazolocytosine Derivatives: Synthesis, PhotophysicalP200 Characterization and Evaluation of Complementary Base
Binding

Institute for Food Systems Biology at
Sharon Istvánffy Leibniz
the Technical University of Munich

P186 Large-scale photolithographic synthesis for dense
information storage in DNA libraries generated from mixedbase and trimer phosphoramidites
Manisha Patel

Institute of Chemical Technology

P187 Sustainable Synthetic Strategies for Modification of
Nucleobases and Nucleoside analogs
Takeshi Yamada

Tokyo Medical and Dental University

P188 Up-regulating of circular RNA production using CLIP-ON
oligonucleotide

method for the synthesis of pyridiniumboranephosphonates andrelated compounds

Daniela Verga Institut Curie
P201 Photoactivatable Warheads for Photoaffinity Labeling ofG-quadruplex Structures
Tun-Cheng Chien

National Taiwan Normal University

P202 Total Synthesis of Pseudouridine
Natsuhisa Oka

Gifu University

P203 One-step synthesis of truncated carbocyclic nucleosides
from sugarderived Julia–Kocienski sulfones

Tony Yan Brock Universityof the detritylation reaction in the solid
P189 Re-examination
phase synthesis of oligonucleotides by thephosphoramidite chemistryP204 Practical synthesis of N-azidomethyl nucleobases andOtto Linden University of Strathclyde
P190 Difluorinated nucleosides: expanding the functional
repertoire of therapeutic oligonucleotides

Yosuke Taniguchi Okayama University
and functional evaluation of artificial
P205 Synthesis
nucleoside derivatives to form the base pair with
2-hydroxy-adenine

Arnab Das Indian Association for the Cultivation of Science

Generation Phosphorodiamidate Morpholino
P191 Next
Oligomers: Synthesis, Biophysical Properties andIntracellular Delivery

Pierre P. M. Junghanns

Saarland University

P192 Chemical Probes to Elucidate Cellular Interactions of
Muraymycin Nucleoside Antibiotics
Joseph S. Vyle

Queen's University Belfast

P193 Synthesis and anticancer activity of selenium-substituted
dinucleoside pyrophosphate analogues

Béatrice Roy University of Montpellier
P194 Solvent-free mechanochemical strategies for the
preparation of dinucleotides and analogues

Yoshiaki Kitamura

Gifu University

their analogs by direct azidomethylation

Yasufumi Fuchi

Tokushima Bunri University

ring-fused 7-Oxabicyclo
P206 Phenanthrene[2.2.1]heptane-2,3-diol derivatives as universal linkers
for solid-phase oligonucleotide synthesis
Harumi Okutsu

Tokyo University of Science

P207 Development of chemoselective condensation reactionof nucleoside 3’ -H-phosphonothioate
Yasuaki Kimura

Nagoya Universityof Chemically Modified mRNA based on
P208 Development
Chemical Synthesis for Highly Efficacious mRNA
Therapeutics

Tomohiko Yamazaki National Institute for Materials Science (NIMS)
of immunostimulatory function of CpG
P209 Enhancement
oligodeoxynucleotides by using the guanine quadruplex
structure as a scaffold

IRT2024

Soichiro Kimura Nagasaki Universityof photo-crosslinking properties ofP210 Evaluation
triplex-forming oligonucleotides and peptide nucleic acids
conjugated to a methyl- substituted psoralen derivative

Yusuke Kawamoto

Kyoto University

P225 Multivalent Dendritic Oligonucleotides for Therapeutic
Applications

P211 ASO-Inspired DNAzyme 10-23 Variants for Enhanced

Shintaro Inaba Tokyo University of Agriculture and Technology
Detection of CpG methylation focusing on structural
P226 change of G-quadruplex forming DNA oligonucleotide
and its binding to myoglobin

Bruno Pagano University of Naples Federico II
Unlocking the potential of protein-derived peptides toP212 target DNA G-quadruplexes: From recognition to
anticancer activityof a photoknockdown method using a
P227 Development
small photosensitizer-conjugated antisense

Dariusz Wawrzyniak The Polish Academy of Sciences
The biological assay of pyrimidine nucleoside dimers
P213 analogues with a short 1,2,3-triazole linker - the second
part of research

Qin Ren Osaka University
Development of simple purification method of chemicallyP228 synthesized oligonucleotides using highly lipophilic
phosphoramidites as capping reagents

Yu Mikame Nagasaki University
Novel psoralen-conjugated triplex-forming
P214 oligonucleotide enables targeting of HTLV-1 provirus
genome sequence in 5'-LTR region

P229 The development of continuous purification process for

Yajun Wang

Hangzhou Institute of Medicine,
Chinese Academy of Sciences

Gene Silencing

Jumpei Ariyoshi

Enhances Antisense Activity of Gapmer-ASOs

Yousuke Katsuda Kumamoto University
P216 In Vivo Manipulation of mRNA Using Staple Oligomers:
Advancing Nucleic Acid-Based Therapies
Tokushima Univ.

Tokyo institute of technology

oligonucleotide

Cheng-Linn Lee

YMC Cooperation, LTD.

oligonucleotides purification and its potential benefits

Kobe pharmaceutical University

P215 Acyclic Nucleic Acids Substitution Reduces Toxicity andNana Mihara

Nanai Yoshida

Yuki Suzuki

Mie University

P230 Self-limited assembly of shape-adjustable DNA origami
plates into desired polygonal rings
Kosuke Machida

Tohoku University

Development of Chimeric Artificial Nucleic Acids (CANA)
P231 Toward Pancreatic Cancer Therapeutics Targeting
Vasohibin-2 II: Investigation of CANA-target RNA
Complex Stability and Its Effect on Cleavage Efficiency.

Sumit Shil

Konan University

P217 DNA chemical synthesis based on a

P232 Triplex nucleic acid induces liquid-liquid phase

Vincent Roy Université d'Orléans
and biological evaluation of new high potent
P218 Synthesis
acyclic nucleoside phosphonate LAVR-289 against DNA
viruses

Yuki Igarashi Tohoku Universityof Chimeric Artificial Nucleic Acids (CANA)
P233 Development
toward Pancreatic Cancer Therapeutics Targeting
BACH1

phosphorofluoridate exchange reaction

Anna L. Malinowska

NATA

P219 Novel phosphoramidite linkers for the synthesis ofoligonucleotide conjugates via thiol-ene click reaction

P220

Emma K. Davison

Auckland University of Technology

Practical and concise synthesis of nucleoside analogues
Risa Yamaguchi

Gifu University

P221 Preparation of thymidine 3 -phosphotriester derivatives
for ynamide-mediated oligonucleotide synthesis
Ramon Eritja

IQAC-CSIC

P222 Biophysical studies of antiparallel clamps for targeting
polypyrimidine sequences through triplex formation
Ilze Kumpina

SUNY Binghamton University

P223 Enhancing Stability in RNA2-PNA Triplexes ThroughNucleobase ModificationsUgnė ŠinkevičiūtėIOCB Prague

P224 Novel 2,6-disubstituted 7-deazapurine ribonucleosides:
synthesis and biological activities

separation

P234

Jakob Zwicker

University of Constance

Identification of AMPylation proteins

Andrei P. Guzaev AM Chemicals LLC
of dGib nucleotide residues in synthetic
P235 Deprotection
oligonucleotides by aqueous ammonia andmethylamine: a kinetic study
Andrei P. Guzaev

AM Chemicals LLC

P236 TRIDENT – a novel universal solid support for
oligonucleotide synthesis
Paul Caffrey

NEB

P237 Bead Enabled Workflows for Oligonucleotide Analysis
and Synthesis

Alva AbrahamssonUmeå University

P238 Selectively target individual G-quadruplex DNA
structures using G4 - Ligand Oligonucleotides

ーTBDー

10:55-12:00

17:10-17:55

Announcements,
presentation of next IRT
and ISNAC