平成25年度 研究成果

【1】原著
Kumaki S, Sasahara Y, Kamachi Y, Muramatsu H, Morio T, Goi K, Sugita K, Urabe T, Takada H, Kojima S, Tsuchiya
S, Hara T:
B cell function after unrelated umbilical cord blood transplantation using minimal-intensity conditioning regimen inpatients with X-SCID.
Int J Hematol. 98: 355-60, 2013
Doi T, Ohga S, Ishimura M, Takada H, Ishii K, Ihara K, Nagai H, Hara T:
Long-term liposteroid therapy for idiopathic pulmonary hemosiderosis.
Eur J Pediatr. 172(11): 1475-81, 2013
Ishimura M, Yamamoto H, Mizuno Y, Takada H, Goto M, Doi T, Hoshina T, Ohga S, Ohshima K, Hara T:
A non-invasive diagnosis of histiocytic necrotizing lymphadenitis by means of gene expression profile analysis ofperipheral blood mononuclear cells.
J Clin Immunol. 33(5): 1018-26, 2013
Ohga S, Kang D, Kinjo T, Ochiai M, Doi T, Ishimura M, Kayamori Y, Urata M, Yamamoto J, Suenobu S, Kanegane H,
Ikenoue T, Shirahata A, Hara T:
Pediatric presentation and treatment of congenital protein C deficiency in Japan.
Haemophilia. 19(3): 378-84, 2013
Inoue H, Ohga S, Kusuda T, Kitajima J, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T:
Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia inpreterm infants.
Early Hum Dev. 89(6):425-9, 2013
Ochiai M, Kinjo T, Takahata Y, Iwayama M, Kenji I, Ohga S, Kotaro F, Wake N, Tagichi T, Hara T:
Clinical outcome of extremely low birth weight infants born at GW22-26: a report from a single institution in Japan.
Neonatology. 105(2):79-84, 2014
Imagawa T, Nishikomori R, Takada H, Takeshita S, Patel N, Kim D, Lheritier K, Heike T, Hara T, Yokota S:
Safety and efficacy of canakinumab in Japanese patients with phenotypes of cryopyrin-associated periodic syndrome asestablished in the first open-label, phase-3 pivotal study (24-week results).
Clin Exp Rheumatol. 31: 302-9, 2013
Yokota S, Nishikomori R, Takada H, Kikuchi M, Nozawa T, Kanetaka T, Kizawa T, Miyamae T, Mori M, Heike T,
Hara T, Imagawa T:
Guidance on the use of canakinumab in patients with cryopyrin-associated periodic syndrome in Japan.
Mod Rheumatol. 23: 425-9, 2013
Yamada T, Saunders T, Kuroda S, Sera K, Nakamura T, Takatsuji T; Fukuoka College of Obstetricians andGynecologists, Pediatric Association of Fukuoka District, Hara T, Nose Y:
Cohort study for prevention of atopic dermatitis using hair mineral contents.
J Trace Elem Med Biol. 27(2): 126-31, 2013
Sugitani M, Fujita Y, Yumoto Y, Fukushima K, Takeuchi T, Shimokawa M, Kato K.
A new method for measurement of placental elasticity: acoustic radiation force impulse imaging.
Placenta. 34(11):1009-13, 2013
Morokuma S, Fukushima K, Kato K.
Relationship between arousal response in newborn infants before micturition and bed-wetting from 5 to 7 years of age.
Early Hum Dev. 2013 Dec;89(12):989-91.
Fujita Y, Satoh S, Sugitani M, Yumoto Y, Fukushima K, Wake N.
Clinical utility of augmentation index as a new parameter of peripheral circulation in human fetuses.
Early Hum Dev. 2013 Aug;89(8):601-5.

Otera Y, Morokuma S, Fukushima K, Wake N, Kato K.
Correlation between regular mouthing movements and heart rate patterns during non-rapid eye movement periods innormal human fetuses between 32 and 40 weeks of gestation.
Early Hum Dev. 2013 Jun;89(6):381-6.
Li D, Takao T, Tsunematsu R, Morokuma S, Fukushima K, Kobayashi H, Saito T, Furue M, Wake N, Asanoma K.
Inhibition of AHR transcription by NF1C is affected by a single-nucleotide polymorphism, and is involved insuppression of human uterine endometrial cancer.
Oncogene. 2013 Oct 10;32(41):4950-9.
Murata M, Fukushima K, Takao T, Seki H, Takeda S, Wake N.
Oxidative stress produced by xanthine oxidase induces apoptosis in human extravillous trophoblast cells.
J Reprod Dev. 2013;59(1):7-13.
Hoang Lan Phuong, Ju Qiu, Takashi Kuwahara, Keiichi Fukui, Kayo Yoshiyama, Kazusato Matsugano, Norihiko
Terahara, Toshiro Matsui: Transepithelial transport of 6-O-caffeoylsophorose across Caco-2 cell monolayers. Food
Chem., 138, 101-106, 2013.
Junko Takeda, Ha-Young Park, Yuri Kunitake, Keiko Yoshiura, Toshiro Matsui: Theaflavins, dimeric catechins, inhibit
peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide
transporter PEPT1. Food Chem., 138, 2140-2145, 2013.
Chihiro Hashimoto, Yuri Iwaihara, Si-Jing Chen, Mitsuru Tanaka, Toshiaki Watanabe, Toshiro Matsui:Highly-sensitive detection of free advanced glycation end-products by liquid chromatography-electrospray ionization
tandem mass spectrometry with 2,4,6-trinitrobenzene sulfonate derivatization. Anal. Chem., 85, 4289-4295, 2013
Ha-Young Park, Yuri Kunitake, and Toshiro Matsui: Benzotropolone moiety in theaflavins is responsible for inhibiting
peptide-transport and activating AMP-activated protein kinase in Caco-2 cells. J. Functional Foods in Health andDisease, 3(5), 111-121, 2013
Eduardo M. N. Nakashima, Hu-Qiang Qing, Mitsuru Tanaka, and Toshiro Matsui: Improvement of liquid
chromatography-tandem mass spectrometric detection of di-peptides by 2,4,6-trinitrobenzene sulfonate derivatization.
Biosci. Biotechnol. Biochem., 77 (10), 2094-2099, 2013.
Y.Miyata, S.Tamaru, T.Tanaka, K.Tamaya, T.Matsui, Y.Nagata, K.Tanaka: Theflavins and theasinensin A derived
from fermented tea have antihyperglycemic and hypotriacylglycerolemic effects in KK-Ay mice and Sprague-Dawley
rats. J. Agric. Food Chem., 61, 9366-9372, 2013
Seong-Min Hong, Mitsuru Tanaka, Saori Yoshii, Yoshinori Mine and Toshiro Matsui: Enhanced visualization of small
peptides absorbed in rat small intestine by phytic-acid-aided MALDI-imaging mass spectrometry. Anal. Chem., 85,
10033-10039, 2013
Ju Qiu, Kanako Maekawa, Yuko Kitamura, Yuji Miyata, Kazunari Tanaka, Takashi Tanaka, Minoru Soga, Takanori
Tsuda, Toshiro Matsui: Stimulation of glucose uptake by theasinensins through the AMP-activated protein kinase
pathway in rat skeletal muscle cells. Biochem. Pharm., 87, 344-351, 2014
Tsujimoto S, Ishida T, Takeda T, Ishii Y, Onomura Y, Tsukimori K, Takechi S, Yamaguchi T, Uchi H, Suzuki SO,
Yamamoto M, Himeno M, Furue M, Yamada H. Selenium-binding protein 1: its physiological function, dependence onaryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochim Biophys
Acta. 2013;1830(6):3616-24.
Tsukimori K, Uchi H, Tokunaga S, Yasukawa F, Chiba T, Kajiwara J, Hirata T, Furue M. Blood levels of PCDDs,
PCDFs, and coplanar PCBs in Yusho mothers and their descendants: association with fetal Yusho disease.
Chemosphere. 2013;90(5):1581-8.
Tsukimori K, Morokuma S, Hori T, Takahashi K, Hirata T, Otera Y, Fukushima K, Kawamoto T, Wake N.
Characterization of placental transfer of polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinatedbiphenyls in normal pregnancy. J Obstet Gynaecol Res. 2013;39(1):83-90.

Morokuma S, Fukushima K, Otera Y, Yumoto Y, Tsukimori K, Ochiai M, Hara T, Wake N. Ultrasound evaluation of
fetal brain dysfunction based on behavioral patterns. Brain Dev. 2013;35(1):61-7.
Nishichi, R., M. Nufuji, Y., Washio, M., and Kumagai, S: Serum brain-indeced neurotrophic factor levels areassociated with dyssomnia in female, but not male, among Japanese workers. Int. Clin. Sleep Med., 9:6490654,2013.
Nishichi R ,Washio, M.,Nofuji,Y., Motomura, K., Ifuku, Y.,Kumagai, S:Effect of exercise training for the chronic
hemodialysis patients. Shimane journal of Medicine science,:29:61-69,2013.
Doi Y, Ninomiya T, Hirakawa Y, Takahashi O, Mukai N, Hata J, Iwase M, Kitazono T, Oike Y, Kiyohara Y:
Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama Study. Diabetes
Care 36: 98-100, 2013
Nakamura Y, Kiyohara Y, Okuda N, Okamura T, Higashiyama A,Watanabe M, Kadota A, Nagasawa S, Miyagawa N,
Ohkubo T, Kita Y, Miura K, Okayama A, Ueshima H, for the NIPPON DATA Research Group: Fatty acid intakes andcoronary heart disease mortality in Japan: NIPPON DATA 90, 1990-2005. Current Nutrition & Food Science 9: 26-32,
2013
Ohkuma T, Fujii H, Iwase M, Kikuchi Y, Ogata S, Idewaki Y, Ide H, Doi Y, Hirakawa Y, Mukai N, Ninomiya T,
Uchida K, Nakamura U, Sasaki S, Kiyohara Y, Kitazono T: Impact of eating rate on obesity and cardiovascular risk
factors according to glucose tolerance status: the Fukuoka Diabetes Registry and the Hisayama Study. Diabetologia 56:
70-77, 2013
Ninomiya T, Kojima I, Doi Y, Fukuhara M, Hirakawa Y, Hata J, Kitazono T, Kiyohara Y: Brachial-ankle pulse wave
velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study. J
Hypertension 31: 477–483, 2013
Soejima N, Ohyagia Y, Nakamura N, Himeno E, M. Iinuma K, Sakae N, Yamasaki , Tabira T, Murakami K, Irie K,
Kinoshita N, F.M. LaFerla, Kiyohara Y, Iwaki T, Kira J: Intracellular accumulation of toxic turn Amyloid-βis
associated with endoplasmic reticulum stress in Alzheimer’s disease. Curr Alzheimer Res 10: 11-20, 2013
The AMD Gene Consortium (Arakawa S, Ishibashi T, Kiyohara Y, Nakamura Y, Kubo M): Seven new loci associatedwith age-related macular degeneration. Nat Genet 45: 433-439, 2013
Ozawa M, Ninomiya T, Ohara T, Doi Y, Uchida K, Shirota T, Yonemoto K, Kitazono T, Kiyohara Y: Dietary patterns
and risk of dementia in an elderly Japanese population: the Hisayama Study. Am J Clin Nutr 97: 1076-1082, 2013
Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N,
Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T: Clinical significance ofplasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study. BMC Neurol 13:32, 2013
Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M,
Hattori M, Oka K, Kagami S, Kawamura T, Takeda T, Hataya H, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N,
Shimizu A, Kitamura H, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Nagata M, Taguchi T, Makino H; Committee forstandardization of renal pathological diagnosis; Committee for kidney disease registry; Japanese society of nephrology:
Japan renal biopsy registry and Japan kidney disease registry: Committee report for 2009 and 2010. Clin Exp Nephrol
17: 155-173, 2013
Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F,
Matsumura K, Kitazono T, Kiyohara Y: White-coat and masked hypertension are associated with carotid
atherosclerosis in a general population: the Hisayama Study. Stroke 44: 1512-1517, 2013
Hirano A, Yamazaki K, Umeno J, Ashikawa K, Aoki M, Matsumoto T, Nakamura S, Ninomiya T, Matsui T, Hirai F,
Kawaguchi T, Takazoe M, Tanaka H, Motoya S, Kiyohara Y, Kitazono T, Nakamura Y, Kamatani N, Kubo M:
Association study of 71 European Crohn's disease susceptibility loci in a Japanese population. Inflamm Bowel Dis 19:
526-533, 2013

Kurabayashi T, Mizunuma H, Kubota T, Kiyohara Y, Nagai K, Hayashi K: Pregnancy-induced hypertension isassociated with maternal history and a risk of cardiovascular disease in later life: a Japanese cross-sectional study.
Maturitas 75: 227-231, 2013
Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, Laferla FM, Kiyohara Y,
Nakabeppu Y: Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama Study. Cereb
Cortex. 2013 Apr 17. [Epub ahead of print]
Kondo I, Ojima T, Nakamura M, Hayasaka S, Hozawa A, Saitoh S, Ohnishi H, Akasaka H, Hayakawa T, Murakami Y,
Okuda N, Miura K, Okayama A, Ueshima H; NIPPON DATA 80 Research Group (Kiyohara Y): Consumption of dairy
products and death from cardiovascular disease in the Japanese general population: the NIPPON DATA 80. J
Epidemiol 23: 47-54, 2013
Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY,
Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H; NIPPON DATA 90 Research Group (Kiyohara
Y): Association between J-point elevation and death from coronary artery disease--15-year follow up of the NIPPONDATA 90. Circ J 77: 1260-1266, 2013
Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao
M, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Kiyohara Y): The
global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, andWestern diet in 1980 and 2008. Circulation 127: 1493-1502, 2013
Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y,
Kitazono T, Kiyohara Y: Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage incoronary atherosclerosis in elders: results from the Hisayama Study. Kidney Int 84: 373-380, 2013
Tokami H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, Kiyohara Y, Kamouchi M, Kitazono T; REBIOS
Investigators: RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic
stroke. Brain Res 1517: 122-132, 2013
Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y:
Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama
Study. Circ J 77: 2311-2317, 2013
Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y: Temporal trends
in sudden unexpected death in a general population: the Hisayama Study. Am Heart J 165: 932-938, 2013
Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y:
Magnesium intake decreases type 2 diabetes risk through the improvement of insulin resistance and inflammation: theHisayama Study. Diabet Med 30: 1487-1494, 2013
Kamouchi M, Sakai H, Kiyohara Y, Minematsu K, Hayashi K, Kitazono T: Acute kidney injury and edaravone in acuteischemic stroke: the Fukuoka Stroke Registry. J Stroke Cerebrovasc Dis 22: e470-476, 2013
Nagata M, Ninomiya T, Kiyohara Y, Murakami Y, Irie F, Sairenchi T, Miura K, Okamura T, Ueshima H;
EPOCH-JAPAN Research Group: Prediction of cardiovascular disease mortality by proteinuria and reduced kidney
function: pooled analysis of 39,000 individuals from 7 cohort studies in Japan. Am J Epidemiol 178: 1-11, 2013
Furuta M, Shimazaki Y, Takeshita T, Shibata Y, Akifusa S, Eshima N, Kiyohara Y, Ninomiya T, Hirakawa Y, Mukai N,
Nagata M, Yamashita Y: Gender differences in the association between metabolic syndrome and periodontal disease:
the Hisayama Study. J Clin Periodontol 40: 743-752, 2013
Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D,
Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y: Secular trends in cardiovascular disease and its risk factors inJapanese: half-century data from the Hisayama Study (1961-2009). Circulation 128: 1198-1205, 2013
Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T,
Kanba S, Kiyohara Y: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: across-sectional study. BMC Public Health 13: 862-868, 2013

Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T,
Kiyohara Y: Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general
Japanese population: the Hisayama Study. Cardiovasc Diabetol 12: 164, 2013
Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M,
Kitazono T, Kiyohara Y: Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk ofcardiovascular disease: the Hisayama Study. Atherosclerosis 231: 261-267, 2013
Nakamura Y, Okamura T, Inohara T, Kohsaka S, Watanabe M, Higashiyama A, Kadota A, Okuda N, Ohkubo T,
Nagasawa SY, Miura K, Okayama A, Ueshima H; NIPPON DATA 80 Research Group (Kiyohara Y): Prognostic
values of bundle branch blocks for cardiovascular mortality in Japanese (24year follow-up of NIPPON DATA 80). J
Electrocardiol 46: 360-365, 2013
Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y,
Kasagi F, Maegawa H, Kashiwagi A, Ueshima H; SESSA Research Group; NIPPON DATA 80/90 Research Group(Kiyohara Y): Carotid intima-media thickness and plaque in apparently healthy Japanese individuals with an estimated10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) guidelines 2012: the Shiga
Epidemiological Study of Subclinical. J Atheroscler Thromb 20: 755-766, 2013
Inohara T, Kohsaka S, Okamura T, Watanabe M, Nakamura Y, Higashiyama A, Kadota A, Okuda N, Ohkubo T, Miura
K, Okayama A, Ueshima H; NIPPON DATA 80/90 Research Group (Kiyohara Y): Long-term outcome of healthy
participants with atrial premature complex: a 15-year follow-up of the NIPPON DATA 90 cohort. PLoS One 8: e80853,
2013
Hiroyuki Kikuchi, Akiko Nanri, Ai Hori, MASAO SATO, Kazuaki Kawai, Hiroshi Kasai, Tetsuya Mizoue,Lower
serum levels of total cholesterol are associated with higher urinary levels of 8-hydroxydeoxyguanosine,Nutirition andMetabolism,10,Art. NO. 59, 2014.03
Ngoc Minh Pham, Akiko Nanri, Takeshi Kochi, Keisuke Kuwahara, Hiroko Tsuruoka, Kayo Kurotani, Shamima Akter,
Isamu Kabe, MASAO SATO, Hitomi Hayabuchi, Tetsuya Mizoue,Coffee and green tea consumption is associated withinsulin resistance in Japanese adults,Metabolism - Clinical and Experimental, 63,3,400-408, 2014.03
Kayo Kurotani, MASAO SATO, Yuko Ejima, Kentaro Kashima, Akiko Nanri, Ngoc Minh Pham, Keisuke Kuwahara,
Tetsuya Mizoue,Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms inadults,e-SPEN Journal,9,1,e7-e12, 2014.02.
Akihiro Ogawa, Yukio Kadooka, Ken Kato, Bungo Shirouchi, MASAO SATO,Lactobacillus gasseri SBT2055 reduces
postprandial and fasting serum non-esterified fatty acid levels in Japanese hypertriacylglycerolemic subjects,Lipids in
Health and Disease,19,13(1),36, 2014.02.
Bungo Shirouchi, Elke Albrecht, Gerd Nuernberg, Steffen Maak, Samadmanivong Olavanh, Yoshinori Nakamura,
MASAO SATO, Takaufmi Gotoh, Karin Nuernberg,Fatty acid profiles and adipogenic gene expression of various fat
depots in Japanese Black and Holstein steers,Meat Science,96,1,157-164, 2014.01.
Yasutake Tanaka, Koji Nagao, Hideaki Nakagiri, Toshirou Nagaso, Yasue Iwasa, Haruhiko Mori, Makoto Asahina,
katsumi imaizumi, MASAO SATO,Unavailability of liver triacylglycerol increases serum cholesterol concentrationinduced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats,Lipids in Health and Disease,13,19-30,
2014.01
Tan, Hui, Furuta, Syoko, Nagata, Toshiro, Ohnuki, Koichiro, Akasaka, Taiki, Bungo Shirouchi, MASAO SATO,
kuniyoshi shimizu,Inhibitory Effects of the Leaves of Loquat on Bone Mineral Density Loss in Ovariectomized Miceand Osteoclast Differentiation,Journal of Agricultural and Food Chemistry,62,4,836-841, 2014.01.
Wataru Mizunoya, Yohei Iwamoto, Bungo Shirouchi, MASAO SATO, Yusuke Komiya, Farzaneh Rahimi Razin,
Ryuichi Tatsumi, Yusuke Sato, Mako Nakamura, Yoshihide Ikeuchi,Dietary fat influences the expression of contractile
and metabolic genes in rat skeletal muscle,PLoS ONE,11,8(11),e80152, 2013.11.
Yukio Kadooka, MASAO SATO, Akihiro Ogawa, Masaya Miyoshi, Hiroshi Uenishi, Hitomi Ogawa, Ken Ikuyama,
Masatoyo Kagoshima, Takashi Tsuchida,Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal

adiposity in adults in a randomized controlled trial,British Journal of Nutrition,110,9,1696-1703,PMID: 23614897,
2013.10.
Masako Iwamoto, kaori Yagi, Kayoko Yazum, Airi Komine, MASAO SATO, Bungo Shirouchi,Eating a healthy lunch
improves serum alanine aminotransferase activity,Lipids in Health and Disease,12,134,134,2013.09.
Ngoc Minh Pham, Shamima Akter, Kayo Kurotani, Akiko Nanri, Masao Sato, Hitomi Hayabuchi, Kazuki Yasuda,
Tetsuya Mizoue,Green tea and coffee consumption is inversely associated with depressive symptoms in a Japaneseworking population,Public Health Nutrition,9,1,PMID: 23453038, Epub ahead of print, 2013.07.
Ayami Kume, Kayo Kurotani, MASAO SATO, Yuko Ejima, Ngoc Minh Pham, Akiko Nanri, Keisuke Kuwahara,
Tetsuya Mizoue,Polyunsaturated fatty acids in serum and homocysteine concentrations in Japanese men and women: across-sectional study,Nutrition & Metabolism,10,1,Article NO. 41, 2013.07.
Akiko Nanri, Minh N Pham, Kayo Kurotani, Ayami Kume, Keisuke Kuwahara, MASAO SATO, Hitomi Hayabuchi,
Tetsuya Mizoue,Serum pyridoxal concentrations and depressive symptoms among Japanese adults: results from aprospective study,European Journal of Clinical Nutrition,PMID: 23801094, 2013.07.
Keisuke Kuwahara, Akiko Nanri, Minh N Pham, MASAO SATO, Kayo Kurotani, Kazuaki Kawai, Hiroshi Kasai,
Tetsuya Mizoue,Serum vitamin B6, folate, and homocysteine concentrations and oxidative DNA damage in Japanese
men and women, Nutrition,29,10,1219-1223, 2013.07.
Akter, S, Kurotani, K, Nanri, A., Pham, N.M, MASAO SATO, Hayabuchi, H., Mizoue, T,Dairy consumption isassociated with decreased insulin resistance among the Japanese,Nutrition Research,33,4,286-292,286-292, 2013.04.
Ngoc Minh Phama, Akiko Nanri, Siyan Yi, Kayo Kurotani,, Shamima Akter, Leng Huat Foo, Nobuo Nishi, MASAO
SATO, Hitomi Hayabuchi, Tetsuya Mizoue,Serum ferritin is associated with markers of insulin resistance in Japanese
men but not in women,Metabolism: Clinical and Experimental,62,4,561-567, 2013.04.
Yamaguchi N, Nakamura S, Yamaza H, Nishigaki S, Masuda K, Yanagita K, Nonaka K. Clinical approach to asuspected case of first branchial arch syndrome. Case Rep Med. 2014 Epub 2014 Jan 12.
Makino Y, Yamaza H, Akiyama K, Ma L, Hoshino Y, Nonaka K, Terada Y, Kukita T, Shi S, Yamaza T. Immune
therapeutic potential of stem cells from human supernumerary teeth. J Dent Res. 2013 Jul;92(7):609-15.
Nagano J, Morita T, Taneichi K, Nagaoka S, Katsube S, Asai T, Yukioka M, Takasugi K, Kondo M, Nishibayashi Y:
Rational/antiemotional behaviors in interpersonal relationships and the functional prognosis of patients with rheumatoid
arthritis: a Japanese multicenter, longitudinal study.
Biopsychosoc Med 8: 8, 2014
Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y,
Kubo C, Kiyohara Y, Sudo N, Hosoi M. Alexithymia is associated with greater risk of chronic pain and negative affectand with lower life satisfaction in a general population: the hisayama study. PLoS One. 2014 Mar 12;9(3).
Yoshihara K, Hiramoto T, Oka T, Kubo C, Sudo N. Effect of 12 weeks of yoga training on the somatization,
psychological symptoms, and stress-related biomarkers of healthy women. Biopsychosoc Med. 2014 Jan 3;8(1):1.
Lkhagvasuren B, Masuno T, Kanemitsu Y, Sudo N, Kubo C, Oka T. Increased prevalence of postural orthostatic
tachycardia syndrome in psychogenic fever patients. Psychother Psychosom. 2013;82(4):269-70.
Nishino R, Mikami K, Takahashi H, Tomonaga S, Furuse M, Hiramoto T, Aiba Y, Koga Y, Sudo N. Commensal
microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based
methods. Neurogastroenterol Motil. 2013 Jun;25(6):521-8.
Zhao P, Hiramoto T, Asano Y, Kubo C, Sudo N. Chronic psychological stress exaggerates the compound48/80-induced scratching behavior of mice. Pharmacol Biochem Behav. 2013 Apr;105:173-6.
Makino S, Jensen MP, Arimura T, Obata T, Anno K, Iwaki R, Kubo C, Sudo N, Hosoi M. Alexithymia and chronic
pain: the role of negative affectivity. Clin J Pain. 2013 Apr;29(4):354-61.

Tomoko Y, Ayumi K, Kiyoko K, Tatsuhiro O, Kanako O, Toshiaki S, and Norio W, : Association of MDM2 SNP309
and TP53 Arg72Propolymorphisms with risk of endometrial cancer. Oncology Reports. 30:25-34, 2013
Wake N, Takao T, Asanoma K, Kato H : Establishment of a new diagnostic method for hydropic villi by using TSSC3
antibody. J Obstet Gynaecol Res. 2013 Jul ;39(7):1230-5
Sato Y, Fujita Y, Anami A, Yumoto Y, Fukushima K, Wake N. : Doppler sonographic evaluation of arteriovenous
shunt flow in a fetus with dural sinus malformation. J Obstet Gynaecol Res. 2013 May;39(5):1081-4.
Hagiwara T, Kaku T, Kobayashi H, Wake N, Saito T. : Well-differentiated villoglandular adenocarcinoma of theuterine cervix: assessment of cytological features by histological subtypes. Acta Cytol. 2013;57(1):61-8.
Sakai A, Fujita Y, Yumoto Y, Fukushima K, Kobayashi H, Wake N. :Successful management of cervico-isthmic
pregnancy delivered at term. J Obstet Gynaecol Res. 2013 Jan;39(1):371-4.
Anami A, Fukushima K, Takasaki Y, Sumida T, Waguri M, Wake N, Murashima A. : The predictive value of anti-SS-A
antibodies titration in pregnant women with fetal congenital heart block. Mod Rheumatol. 2013 Jul;23(4):653-8
Badriah F, Abe T, Miyamoto H, Moriya M, Babazono A, Hagihara A. Interaction effects between rehabilitation
effectiveness and discharge destination upon a inpatient’s subsequent functional abilities.
Journal of Rehabilitation Research and Development 2013; 50(6):821-834.
Hagihara A, Hasegawa M, Abe T, Wakata Y, Nagata T, Nabeshima Y. Prehospital Lactated Ringer's Solution
Treatment and Survival in Out-of-Hospital Cardiac Arrest: A Prospective Cohort Analysis.
PLoS Medicine 10(2): e1001394.
Hagihara A, Hasegawa M, Hinohara Y, Abe T, Motoi M. The aging population and future demand for emergency
ambulances in Japan.
Internal and Emergency Medicine 2013; 8:431-437.
Hagihara A, Abe T, Omagari M, Motoi M, Nabeshima Y. The impact of newspaper reporting of hydrogen sulfide
suicide on imitative suicide attempts in Japan.
Social Psychiatry and Psychiatric Epidemiology 2014; 49:221-229.
Fase B, Abe T, Ikeda K, Kuroda K, Nabeshima Y, Hagihara A. Predicting the length of hospital stay of psychiatry
patients using signal detection analysis.
Psychiatry Research 2013; 210:1211-1218.
Hagihara A, Hasegawa M, Abe T, Nagata T, Nabeshima Y. Physician presence in an ambulance car is associated withincreased survival in out-of-hospital cardiac arrest: A prospective cohort analysis.
PLoS ONE 9(1): e84424. doi:10.1371/journal.pone.0084424.
Nagata T, Abe T, Hasegawa M, Noda E, Hashizume M, Hagihara A. Factors associated with the clinical outcomes ofpediatric out-of-hospital cardiac arrest in Japan.
BMJ Open 2014;4:e003481. doi:10.1136/bmjopen-2013-003481.
Chang S-S, Chen Y-Y, Yip PSF, Lee WJ, Hagihara A, Gunnell D. (2014) Regional Changes in Charcoal-Burning
Suicide Rates in East/Southeast Asia from 1995 to 2011: A Time Trend Analysis. PLoS Medicine 11(4): e1001622.
doi:10.1371/journal.pmed.1001622
前置胎盤初妊婦では妊娠高血圧症候群発症の頻度が低い
福嶋 恒太郎 加藤 聖子
産婦人科の実際62巻13号 Page2197-2200, 2013.12

周産期登録データベース22,359分娩の解析から

齊藤貴文、崎田正博、森山善彦、西内久人、古賀崇正、熊谷秋三．：歩行活動と生活活動を含めた総身体活
動量と運動器疼痛との関連性について-地域在住高齢者を対象として-．日本運動器疼痛学会誌 2013;5:20-27．
齊藤貴文、崎田正博、森山善彦、西内久人、古賀崇正、熊谷秋三．：3軸加速度計による生活活動量および座業時間と膝痛有訴率との関連性-地域在住自立高齢者を対象として-．日本運動器疼痛学会誌 2013;116-123．

本田貴紀，岸本裕歩，山下幸子，熊谷秋三：勤労者のメタボリックシンドロームと抑うつ：勤労者を対象とした2コホート研究.健康科学,35:33-43, 2013.
熊谷秋三, 畑山知子, 西内久人, 戸高裕子：握力増強・健康増進用具「にぎってぎらん」の印象評価．健康科
学,35:71-76, 2013
萩原明人、垂水公男．職域におけるメンタルヘルス対策事業への多面的事業評価手法の適用．
日本衛生学雑誌．2013; 68:72-77.
垂水公男、萩原明人．職場メンタルヘルス対策の費用便益分析．
日本衛生学雑誌．2013; 68:67-71.
飯村佳織、宮崎彰吾、坂部昌明、萩原明人. はり師きゅう師が関与したわいせつ行為に関する新聞記事の分析.
社会鍼灸学研究会 2013; 7:51-62.
濱嵜朋子、佐藤公彦、萩原明人. 歯科医事訴訟における歯科医師の法的責任と年次的変遷に関する研究.
日本歯科医療管理学会誌．2013; 48(1):64-71.
安部猛、長谷川学、萩原明人. 乳児の院外心肺機能停止後の生存に関連する救命措置－探索的分析－.
日本SIDS・乳幼児突然死予防学会雑誌 2013; 13(1): 8-16.
【2】総説
Ohga S, Ishiguro A, Takahashi Y, Shima M, Taki M, Kaneko M, Fukushima K, Kang D, Hara T, on behalf of the Japan
Childhood Thrombophilia Study Group:
Protein C deficiency as the major cause of thrombophilias in childhood.
Pediatr Int. 55(3): 267-71, 2013
Radak, Z., Koltai, E., W.Taylor, A., Higuchi, M., Kumagai, S., Ohno, H, Goto, S., Boldogh, I.: Redox-regulating
sirtuins in aging, caloric restriction, and exercise. Free Radical Biol. Med., 58:87-97,2013.
原 寿郎：
2.幹細胞異常と内科系疾患、現状と展望
日本内科学雑誌102(9): 2255-61, 2013

1）造血幹細胞の異常：先天性免疫不全症

原 寿郎：
小児感染・免疫疾患の発症におけるヒト－環境相互作用
小児感染免疫25(1): 41-53，2013
原 寿郎：
シリーズ小児医療第6回 原発性免疫不全症研究：最新の進歩
あいみっく34(3): 50-5，2013
原 寿郎：
急性散在性脳脊髄炎（ADEM）の診断基準と治療
日本臨牀71(5): 887-92, 2013
原 寿郎：
Ⅱ 中枢神経系感染症 その他の中枢神経系感染症
別冊日本臨牀25: 144-7, 2013

急性散在性脳脊髄炎（ADEM）

原 寿郎：＜Clinical Science＞自然免疫が関与する炎症性疾患：川崎病
炎症と免疫21(6): 62-7, 2013
原 寿郎：
5. 不応例・重症例のBasic Science
小児科臨床66(1): 45-52, 2013
礒部菜摘、石﨑義人、原寿郎：

1）病因・病態からみた考察

＜脳炎・脳症・髄膜炎の病態＞
小児内科45(2): 179-82, 2013

脳炎・脳症と自己免疫

原 寿郎：
こどもの発熱の原因とその対処法
ふたば(77) 2013
戸田尚子、原 寿郎：
2.疾患と栄養 先天性免疫不全症と低栄養
臨床栄養 2014（印刷中）礒部菜摘、鳥巣浩幸、原 寿郎：
中枢性脱髄性疾患 横断性脊髄炎
日本臨牀 2014.3（印刷中）
原 寿郎：
急性散在性脳脊髄炎
日本臨牀 2014.3（印刷中）
藤原 ありさ, 福嶋 恒太郎, 加藤 聖子, 江角 元史郎, 田口 智章【周産期の画像診断 第2版】 胎児診断から新生児診断へ イレウス
周産期医学(0386-9881)43巻増刊 Page710-714(2013.12)
杉谷 麻伊子, 藤田 恭之, 福嶋 恒太郎, 加藤 聖子【周産期の画像診断 第2版】 母体・胎児編 超音波診断
周産期医学43巻増刊 Page237-241(2013.12)

H.胎盤・臍帯・羊水

胎盤の超音波像(解説/特集)

諸隈 誠一, 川合 伸幸, 友永 雅己, 福嶋 恒太郎, 加藤 聖子
産婦人科研究 異種分野との共存 チンパンジーを用いた胎児学習能に関する研究
産婦人科の実際62巻9号 Page1276-1277(2013.09)
福嶋 恒太郎, 加藤 聖子【意識障害のプライマリーケア】 各領域における意識障害の対応
臨牀と研究90巻3号 Page337-341(2013.03)

産科領域における意識障害

諸隈 誠一, 福嶋 恒太郎, 加藤 聖子【脳性麻痺と産科医療補償制度】 低酸素性虚血性脳症による脳性麻痺
周産期医学(0386-9881)43巻2号 Page170-174(2013.02)

胎児期画像・運動様式

福田俊彦、松井利郎
低分子ペプチドの血管機能改善作用
BIOINDUSTRY, 30(2), 40-46 (2013)
熊谷秋三：認知機能、抗うつ作用と脳由来栄養因子（BDNF）～運動効果から～．Food Style 21, 4月号：42-45,2013.
佐藤 匡央, 森田有紀子, プロバイオティクスの抗メタボリックシンドローム効果, The New Food Industry,
2013.05.
須藤 信行. ヒトのストレス応答: 生体機能調整系のストレス反応.

Surgery Frontier. 2013;20:401-405.

須藤 信行. 腸内フローラとストレス. 皮膚の科学. 2013;12:37-41.
野崎 剛弘, 須藤信行, 他. 肥満の認知行動療法: 集団治療の試み. 日本心療内科学会誌. 2013;17:220-225.
【3】著書
原 寿郎：
第1章：血液系疾患の医療ニーズ 第3節
希少疾患／難病の診断・治療と製品開発
原寿郎：

原発性免疫不全症候群（株）技術情報協会 東京

p593-6102013小児の重症筋無力症 myasthenia gravis(MG) in children
今日の治療指針2013年版－私はこう治療している 医学書院

東京

p1229

2013

原 寿郎：
序
標準小児科学

第8版

監修：内山

聖

編集：原

寿郎/高橋孝雄/細井

創

医学書院

東京

2014

原 寿郎：
小児の成長
標準小児科学

第8版

監修：内山

聖

編集：原

寿郎/高橋孝雄/細井

創

医学書院

東京

2014

原 寿郎：
小児の発達
標準小児科学

第8版

監修：内山

聖

編集：原

寿郎/高橋孝雄/細井

創

医学書院

東京

2014

原 寿郎：
免疫疾患
標準小児科学

第8版

監修：内山

聖

編集：原

寿郎/高橋孝雄/細井

創

医学書院

東京

2014

原 寿郎：
原発性免疫不全症候群 Primary immunodeficiency syndrome
今日の治療指針2014年版－私はこう治療している 監修：山口
小室一成 医学書院 東京 2014（印刷中）
楠田 剛、大賀正一：
新生児溶血性貧血
日本臨床別冊「血液症候群Ⅰ」日本臨牀社

p364-367

徹/北原光夫

総編集：福井次矢/高木

誠/

2013

諸隈誠一（分担執筆）：
目でみる妊娠と出産 編集 馬場一憲, 文光堂, 東京, 2013年9月
・胎児の行動 生活パターン p26-28
・Column：最新の研究から-中枢神経の発達を捉える- p48-50
佐藤 匡央, 森田有紀子, 食品機能性成分の吸収・代謝機構, 監修： 宮澤陽夫, 株式会社シーエムシー出版, 第4 章 脂肪酸・油脂類 5. 油脂成分（植物ステロール・ステロールエステル） p174-183,2013【4】症例報告
Ninomiya T, Takada H, Nagatomo Y, Nanishi E, Nagata H, Yamamura K, Doi T, Ikeda I, Hara T:
Development of Kawasaki disease in a patient with PFAPA.
Pediatr Int. 55(6): 801-2, 2013
Koga Y, Oba U, Takimoto T, Suminoe A, Takada H, Hara T:
Polymyxin B-immobilized fiber column hemoperfusion therapy for septic shock.
Shock. 40: 233, 2013
Doi T, Ohga S, Ito N, Ishimura M, Suga N, Nomura A, Takada H, Matsumoto M, Fujimura Y, Hara T:
Limited renal prophylaxis in regular plasmatherapy for heritable ADAMTS13 deficiency.
Pediatr Blood Cancer. 60(9): 1557-8, 2013
Matsunaga Y, Ohga S, Kinjo T, Ochiai M, Fukumoto Y, Ito N, Doi T, Kang D, Hara T:
Neonatal asphyxia and renal failure as the presentation of severe protein C deficiency.
J Perinatol. 33(3): 239-41, 2013
Fukazawa M, Hoshina T, Nanishi E, Nishio H, Doi T, Ohga S, Hara T:
Neonatal hemophagocytic lymphohistiocytosis associated with a vertical transmission of coxsackievirus B1.
J Infect Chemother. 19(6):1210-3, 2013
Hoshina T, Nakashima Y, Sato D, Nanishi E, Nishio H, Nakgata H, Yamamura K, Doi T, Shiokawa Y, Kang D, Ohga S,
Hara T:
Staphylococcal endocarditis as the first manifestation of heritable protein C deficiency in childhood.

J Infect Chemother. 20(2):128-30, 2013
Narazaki R, Makimura M, Sanefuji M, Fukamachi S, Akiyoshi H, So H, Yamamura K, Doizaki S, Kojima S, Ihara K,
Hara T, Ohga S:
Bilateral stenosis of carotid siphon in Hutchinson-Gilford progeria syndrome.
Brain Dev. 35(7): 690-3, 2013
Higuchi Y, Shimizu J, Hatanaka M, Kitano E, Kitamura H, Takada H, Ishimura M, Hara T, Ohara O, Asagoe K, Kubo
T:
The identification of a novel splicing mutation in C1qB in a Japanese family with C1q deficiency: a case report.
Pediatr Rheumatol Online J. 11(1): 41, 2013
Sakai A, Fujita Y, Yumoto Y, Fukushima K, Kobayashi H, Wake N.
Successful management of cervico-isthmic pregnancy delivered at term.
J Obstet Gynaecol Res. 2013 Jan;39(1):371-4. doi: 10.1111/j.1447-0756.2012.01967.x. Epub 2012 Jul 29.
Sato Y, Fujita Y, Anami A, Yumoto Y, Fukushima K, Wake N.
Doppler sonographic evaluation of arteriovenous shunt flow in a fetus with dural sinus malformation.
J Obstet Gynaecol Res. 2013 May;39(5):1081-4. doi: 10.1111/jog.12023. Epub 2013 Apr 4.
Sato M, Tsukimori K, Fujita Y, Morihana E, Fusazaki N, Takahata Y, Kado H. Prenatal diagnosis of coarctation of theaorta using 4-dimensional fetal echocardiography with power Doppler imaging and spatiotemporal image correlation. J
Ultrasound Med. 2013;32(4):719-21.
Tsukimori K, Morihana E, Fusazaki N, Fujita Y. Prenatal images of left hemitruncus in Tetralogy of Fallot with an
absent pulmonary valve. Pediatr Cardiol. 2013;34(5):1285-7.
Tsukimori K, Hamasaki Y, Morihana E, Fusazaki N, Fujita Y, Takahata Y, Oda S, Kado H. Aortic regurgitation
associated with critical aortic stenosis in a fetus. Pediatr Cardiol. 2013;34(4):1020-3.
Oka T, Kanemitsu Y, Sudo N, Hayashi H, Oka K. Psychological stress contributed to the development of low-grade
fever in a patient with chronic fatigue syndrome: a case report. Biopsychosoc Med. 2013 Mar 8;7(1):7.
増田啓次, 柳田憲一, 小笠原貴子, 山座治義, 大隈由紀子, 西垣奏一郎, 廣藤雄太, 野中和明, 先天性全盲，精神遅滞および下垂体機能低下症を合併する透明中隔視神経異形成症の患児に全身麻酔下で歯科治療を行った
1例, 日本障害者歯科学会雑誌 35(1): 22 -27 2013
増田啓次, 山座治義, 西垣奏一郎, 小笠原貴子, 大隈由紀子, 柳田憲一, 野中和明, Hallermann, Streiff症候群に歯肉腫瘤を伴う先天歯を認めた1例, 小児歯科学会雑誌 51(4): 461-466 2013
増田啓次, 小笠原貴子, 山座治義, 大隈由紀子, 西垣奏一郎, 廣藤雄太, 柳田憲一, 野中和明, Langer-Giedion症
候群に埋伏過剰歯, 永久歯萌出遅延, 叢生を認めた1例, 小児歯科学会雑誌51(4): 467 -472 2013
増田啓次, 大隈由紀子, 小笠原貴子, 山座治義, 西垣奏一郎, 柳田憲一, 廣藤雄太,野中和明, 6か月齢でLowe症
候群と診断された1症例の歯科的所見, 小児歯科学会雑誌51(4): 473 -478 2013
西原 智恵, 須藤信行, 他. たこつぼ型心筋症を合併した神経性食欲不振症の2例. 心身医学. 2014;54:67-74.