平成24年度 研究成果

【1】原著
Yamada T, Saunders T, Kuroda S, Sera K, Nakamura T, Takatsuji T, Hara T, Nose Y, Fukuoka College of Obstetriciansand Gynecologists, Pediatric Association of Fukuoka District:
Cohort study for prevention of atopic dermatitis using hair mineral contents.
J Trace Elem Med Biol. 27(2):126-31, 2013

Hoshina T, Kusuhara K, Saito M, Mizuno Y, Hara T:
NKRP1A+ γδ and αβ T cells are preferentially induced in patients with Salmonella infection.
Hum Immunol 73:623-8, 2012

Yamamura K, Ihara K, Ikeda K, Nagata H, Mizuno Y, Hara T:
Histo-blood group gene polymorphisms as potential genetic modifiers of the development of coronary artery lesions inpatients with Kawasaki disease.
Int J Immunogenet 39(2):119-25, 2012

Onoyama S, Ihara K, Yamaguchi Y, Ikeda K, Yamaguchi K, Yamamura K, Hoshina T, Mizuno Y, Hara T:
Genetic susceptibility to Kawasaki disease: analysis of pattern recognition receptor genes.
Hum Immunol 73(6):654-60, 2012

Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S, Miura M,Nomura Y, Fuse S, Ichida F, Seki M, Fukazawa R, Ogawa C, Furuno K, Tokunaga H, Takatsuki S, Hara S, Morikawa A,
on behalf of the RAISE study group investigators:
Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki
disease (RAISE study): a randomised, open-label, blinded-endpoints trial.
Lancet 379:1613-20, 2012

Nozaki T, Takada H, Ishimura M, Ihara K, Imai K, Morio T, Kobayashi M, Nonoyama S, Hara T:
Endocrine complications in primary immunodeficiency diseases in Japan.
Clin Endocrinol (Oxf) 77(4):628-34, 2012

Hikino S, Ohga S T, Kinjo T, Kusuda T, Ochiai M, Inoue H, Honjo S, Ihara K, Ohshima K, Hara T:
Tracheal aspirate gene expression of preterm newborns developing bronchopulmonary dysplasia.
Pediatr Int 54(2):208-14, 2012

Obinata K, Lee T, Niizuma T, Kinoshita K, Shimizu T, Hoshina T, Sasaki Y, Hara T:
Two cases of partial dominant interferon-γ receptor 1 deficiency that presented with different clinical courses of bacilleCalmette-Guérin multiple osteomyelitis.
J Infect Chemother Oct 11, 2012 [Epub ahead of print]

Junko Kitajima, Hirosuke Inoue, Shouichi Ohga, Tadamune Kinjo, Masayuki Ochiai, Takahisa Yoshida, Koichi
Kusuhara, Toshiro Hara:
Differential transmission and postnatal outcome in triplets with congenital cytomegalovirus infection.
Pediatr Development Patho 15:151-5, 2012

Yamamura K, Nagata H, Ikeda K, Ihara K, Hara T:
Efficacy of bosentan therapy for segmental pulmonary artery hypertension due to pulmonary atresia with majoraortopulmonary collateral arteries in children.
Int J Cardiol 161(1):e1-3, 2012

Murata K, Hoshina T, Saito M, Ohkusu K, Yamamura K, Tanoue Y, Ihara K, Hara T:
Bacterial pericarditis caused by Lactobacillus iners in an infant.
Diagn Microbiol Infect Dis 74(2):181-2, 2012

Matsuo T, Ihara K, Ochiai M, Kinjo K, Yoshikawa Y, Kojima-Ishii K, Noda M, Mizumoto H, Misaki M, Minagawa K,Tominaga K, Hara T:
Hyperinsulinemic hypoglycemia of infancy in Sotos syndrome.
Am J Med Genet A 161A(1):34-7, 2013

Ihara K, Yoshino M, Hoshina T, Harada N, Kojima-Ishii K, Makimura M, Hasegawa Y, Watanabe Y, Yamaguchi S,Hara T:
Coagulopathy in patients with late-onset ornithine transcarbamylase deficiency in a remission state: a previously
unrecognized complication.
Pediatrics 131(1):e327-30, 2013

Tsuji G, Takahara M, Uchi H, Matsuda T, Chiba T, Takeuchi S, Yasukawa F, Moroi Y, Furue M:
Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its
anti-inflammatory effect.
J Invest Dermatol 132(1):59-68, 2012

Chiba T, Chihara J, Furue M:Role of the Arylhydrocarbon Receptor (AhR) in the Pathology of Asthma and COPD.
J Allergy (Cairo) 2012;2012:372384, Epub 2012 Jan 29

Tsukimori K, Morokuma S, Hori T, Takahashi K, Hirata T, Otera Y, Fukushima K, Kawamoto T, Wake N:
Characterization of placental transfer of polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinatedbiphenyls in normal pregnancy.
J Obstet Gynaecol Res 39:83-90, 2013

Tsukimori K, Yasukawa F, Uchi H, Furue M, Morokuma S:
Sex ratio in two generations of the Yusho cohort.
Epidemiology 23:349-50, 2012

Fukushima K, Tsukimori K, Li D, Takao T, Morokuma S, Kato K, Seki H, Takeda S, Matsumura S, Wake N:
Effect of transient TCDD exposure on immortalized human trophoblast-derived cell lines.
Hum Exp Toxicol 31:550-6, 2012

Nakayama J, Yokohata R, Sato M, Suzuki T, Matsufuji T, Nishiguchi K, Kawai T, Yamanaka Y, Nagata K, Tanokura M,Sonomoto K:
Development of a Peptide Antagonist against fsr Quorum Sensing of Enterococcus faecalis.
ACS chemical biology 8(4):804-11, 2013

Nakayama J, Jiang J, Watanabe K, Chen K, Ninxin H, Matsuda K, Kurakawa T, Tsuji H, Sonomoto K, Lee YK:
Up to species-level community analysis of human gut microbiota by 16S rRNA amplicon pyrosequencing.
Bioscience Microflora Food Health 32:69-76, 2013

Desouky S, Nishiguchi K, Zendo T, Igarashi Y, Williams P, Sonomoto K, Nakayama J:
High-Throughput Screening of Inhibitors Targeting Agr/Fsr Quorum Sensing in Staphylococcus aureus andEnterococcus faecalis.
Biosci Biotechnol Biochem 77(5):923-7, 2013 (in press)

Teixeira N, Santos S, Marujo P, Yokohata R, Iyer VS, Nakayama J, Hancock LE, Serror P, Silva Lopes Mde F:
The incongruent gelatinase genotype and phenotype in Enterococcus faecalis are due to shutting off the ability torespond to the gelatinase biosynthesis-activating pheromone (GBAP) quorum-sensing signal.
Microbiology 158:519-28, 2012

Sawa N, Wilaipun P, Kinoshita S, Zendo T, Leelawatcharamas V, Nakayama J, Sonomoto K:
Isolation and characterization of enterocin W, a novel two-peptide lantibiotic produced by Enterococcus faecalis
NKR-4-1.
Appl Environ Microbiol 78:900-3, 2012

Puramattathu TV, Islam MR, Nishie M, Yanagihara S, Nagao J, Okuda K, Zendo T, Nakayama J, Sonomoto K:
Enhanced production of nukacin D13E in Lactococcus lactis NZ9000 by the additional expression of immunity genes.
Appl Microbiol Biotechnol 93:671-8, 2012

Perez RH, Himeno K, Ishibashi N, Masuda Y, Zendo T, Fujita K, Wilaipun P, Leelawatcharamas V, Nakayama J,Sonomoto K:
Monitoring of the multiple bacteriocin production by Enterococcus faecium NKR-5-3 through a developed liquid
chromatography and mass spectrometry-based quantification system.
J Biosci Bioeng 114:490-6, 2012

Patching SG, Edara S, Ma P, Nakayama J, Hussain R, Siligardi G, Phillips-Jones MK:
Interactions of the intact FsrC membrane histidine kinase with its pheromone ligand GBAP revealed throughsynchrotron radiation circular dichroism.
Biochim Biophys Acta 1818:1595-602, 2012

Masuda Y, Zendo T, Sawa N, Perez RH, Nakayama J, Sonomoto K:
Characterization and identification of weissellicin Y and weissellicin M, novel bacteriocins produced by Weissella
hellenica QU 13.
J Appl Microbiol 112:99-108, 2012

Iwatani S, Yoneyama F, Miyashita S, Zendo T, Nakayama J, Sonomoto, K:
Identification of the genes involved in the secretion and self-immunity of lacticin Q, an unmodified leaderlessbacteriocin from Lactococcus lactis QU 5.
Microbiology 158:2927-35, 2012

Islam MR, Nishie M, Nagao J, Zendo T, Keller S, Nakayama J, Kohda D, Sahl HG, Sonomoto K:
Ring A of nukacin ISK-1: a lipid II-binding motif for type-A(II) lantibiotic.
J Am Chem Soc 134:3687-90, 2012

Ishibashi N, Himeno K, Fujita K, Masuda Y, Perez RH, Zendo T, Wilaipun P, Leelawatcharamas V, Nakayama J,Sonomoto K:
Purification and characterization of multiple bacteriocins and an inducing peptide produced by Enterococcus faecium
NKR-5-3 from Thai fermented fish.
Biosci Biotechnol Biochem 76:947-53, 2012

Himeno K, Fujita K, Zendo T, Wilaipun P, Ishibashi N, Masuda Y, Yoneyama F, Leelawatcharamas V, Nakayama J,Sonomoto K:
Identification of enterocin NKR-5-3C, a novel class IIa bacteriocin produced by a multiple bacteriocin producer,Enterococcus faecium NKR-5-3.
Biosci Biotechnol Biochem 76:1245-7, 2012

Byun EB, Korematsu S, Ishikawa T, Nishizuka T, Ohshima S, Kanda T, Matsui T:

Apple procyanidins induce hyperpolarization of rat aorta endothelial cells via activation of K+ channels.
J Nutr Biochem 23(3):278-86, 2012

Tokuda S, Fukuda T, Kobayashi Y, Tanaka M, Matsui T:
Uncharged imidazolium moiety in adenine is responsible for endothelium-independent relaxation in contracted thoracic
aorta of Sprague-Dawley rats.
Biosci Biotechnol Biochem 76(4):828-30, 2012

Kobayashi Y, Fukuda T, Tanaka M, Matsui T:
The anti-atherosclerotic di-peptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca2+ channels in
rat vascular smooth muscle cells.
FEBS Open Bio 17(2):83-8, 2012

Kovacs-Nolan J, Zhang H, Ibuki M, Nakamori T, Yoshiura K, Turner PV, Matsui T, Mine Y:
The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation.
Biochim Biophys Acta 1820(11):1753-63, 2012

Byun EB, Ishikawa T, Suyama A, Kono M, Nakashima S, Kanda T, Miyamoto T, Matsui T:
A procyanidin trimer, C1, promotes NO production in rat aortic endothelial cells via both hyperpolarization andPI3K/Akt pathways.
Eur J Pharmacol 692(1-3):52-60, 2012

Qiu J, Kitamura Y, Miyata Y, Tamaru S, Tanaka K, Tanaka T, Matsui T:
Transepithelial transport of theasinensins through Caco-2 cell monolayers and their absorption in Sprague-Dawley rats
after oral administration.
J Agric Food Chem 60(32):8036-43, 2012

Tanaka M, Zhao J, Suyama A, Matsui T:
Epigallocatechin gallate promotes the vasorelaxation power of the anti-atherosclerotic
dipeptide Trp-His in contracted rat aorta.
J Agric Food Chem 60(36):9048-54, 2012【2】総説
磯部菜摘、石﨑義人、原脳炎・脳症と自己免疫小児内科 45(2)、2013

寿郎：

原寿郎：

エビデンスから探る川崎病の最適治療法 Update－IVIG 不応例の新知見と今後の治療戦略－
不応例・重症例の Basic Science1）病因・病態からみた考察

小児科臨床 66(1)、2013

原寿郎：

急性散在性脳脊髄炎(ADEM)の診断基準と治療
日本臨牀 71(5)、2013

原寿郎：神経・筋疾患における免疫療法
小児内科 44(9)：1449-1452、2012

原寿郎：

原発性免疫不全症(PID)－悪性腫瘍，血液疾患を合併する PID を中心に－
日本小児血液・がん学会雑誌 49(3)：237-241、2012

高田英俊、大賀正一、原自己炎症症候群.

特集寿郎：
知っておきたい最新の免疫不全症候群分類－診断から治療まで－

小児科診療 76(3)、2012

【3】著書
原寿郎：

原発性免疫不全症候群
今日の治療と看護原Primary immunodeficiency syndrome

改訂第 3 版

南江堂、東京、2013

寿郎：

免疫疾患
標準小児科学第8版

監修：内山聖、編集：原寿郎/高橋孝雄/細井中)

原寿郎：各論 I．免疫性中枢神経疾患

C. 急性散在性脳脊髄炎(ADEM)

免疫性神経疾患ハンドブック

編集：楠進、南江堂、東京、2013

創、医学書院、東京、2012（印刷原寿郎：

第 1 章：血液系疾患の医療ニーズ

第3節

希少疾患／難病の診断・治療と製品開発

原

原発性免疫不全症候群（株）技術情報協会、2012 年 10 月、東京、p593-610

寿郎：

小児多発性硬化症

pediatric multiple sclerosis

今日の小児治療指針

第 15 版

総編集：大関武彦/古川漸/横田俊一郎/水口雅、医学書院、2012 年 2 月、東京、p631-632

原寿郎：

リウマチ熱
今日の治療指針～私はこう治療している2012 年版、編集：山口徹/北原光夫/福井次矢、医学書院、2012

年 1 月、東京 p1172

原寿郎：4.発熱の診断における自己炎症性疾患・原発性免疫不全症の位置づけ
自己炎症性疾患・自己免疫不全症とその近縁疾患、編集：近藤直実/平家俊男、診断と治療社、2012 年 11 月、
東京 p47-52

原寿郎：

23

免疫不全

免疫学コア講義原

改訂 3 版、編集：熊ノ郷淳/阪口薫雄/竹田潔/吉田裕樹、南山堂、2012 年 11 月、東京 p234-252

寿郎：発熱の原因と診断
小児の発熱

原

A to Z、編著：原寿郎、診断と治療社、2012 年 4 月、東京、p1-12

寿郎：その他の自己免疫・免疫関連疾患
小児の発熱

原A to Z、編著：原寿郎、診断と治療社、2012 年 4 月、東京、p103-105

寿郎：

自己炎症性疾患
小児の発熱

総論

A to Z、編著：原【4】症例報告

寿郎、診断と治療社、2012年4月、東京、p198-199

柳田憲一、山座治義、増田啓次、西垣奏一郎、大隈由紀子、小笠原貴子、野中和明
幼少期から口腔管理を行ったAlagille症候群の2例
小児歯科学雑誌 50(5):430-8, 2012

増田啓次、中村志保、松石裕美子、西垣奏一郎、山座治義、柳田憲一、野中和明
下顎乳臼歯部舌側歯肉に歯胚様組織を含む腫瘤を認めた1例
小児歯科学雑誌 50(4):297-303, 2012

山口登、大隈由紀子、山座治義、増田啓次、柳田憲一、西垣奏一郎、野中和明
ウイリアムズ症候群2例の歯科的特徴および臨床的対応
小児歯科学雑誌 50(3):256-63, 2012

増田啓次、山口登、山座治義、柳田憲一、野中和明
生体肝移植術を予定された患児の口腔内感染病巣除去を目的にう蝕に罹患した全乳歯を抜去した 1 症例
日本障害者歯科学会雑誌 33(1):66-73, 2012