Biologics Formulation

Nail down the right formulation faster
Freeslate takes on your entire biologics formulation development process andautomates it end to end. It’ll tackle buffer prep, buffer exchange, pH checks, sample
prep and analysis. Get your accelerated stability studies done with integrated
sample incubation and automated freeze/thaw systems. So you can take on moredevelopability screens, check out a wider formulation space and find the most stablebiologic this month, not this year.
• Characterize formulations with limited material• Developability and preformulation screens• Robustness and stress studies• Measure pH, viscosity, turbidity and visible particles• Manage and track formulations and analytical results

Gear up for anything
Prepare, stress and analyze hundreds of formulations in parallel in a couple of days —hands off. Freeslate also corrals your formulation info into a single location for easy
reporting and analysis. Do it all using a single, configurable platform and crank throughmore candidates and formulations than ever.

13
4

1
2
3
4
56

2
567

8

94-Tip pH probe
Buffer exchange module
Volume check
Viscosity station
Visual inspection stationVial capping and decapping station

1011127 Vortexing station
8 Cooled storage bay
9 3-Position passive rack
10 Tip/rack holder
11 Wash station
12 Tip/rack holder

Ditch dialysis
Freeslate lets you skip the dialysis cassettes, desalting columns and trips to the centrifuge that come with manual processes. It automates plate-based buffer exchange withas little as 150 µL of sample. Churn out more protein formulations and use the time you
get back for the other big things on your to-do list.

freeslate system with buffer exchange module (left)

Stress out your proteinsPut your proteins through their paces. Agitate, freeze/thaw or crank up the heat andsee how they deal. Shake, spin and visually inspect right on the deck to see if they
aggregate. Ramp temps up or down to check out what they do in various climates. Take
it up a notch with incubators and a scheduler to automate accelerated and long-term
stability studies.

Vortexing station

Heating/cooling/stirring station

Slam through your analytical measurements
Freeslate lets you add the tools you need to find out which formulations make the cut.
On-deck analytics check pH, measure viscosity, assess turbidity and count large visualparticles. Up your arsenal with on-deck 3rd-party analytics like UV/Vis and DLS, orautomate your sample prep for off-deck HPLC and CE analysis.

Multi-channel pH probe

Viscosity station

Visual inspection station

Break through bottlenecks
LEA doesn’t move the bottleneck, it totally unclogs it. You get intuitive experimental
design that makes sense on the front end and full integration with analytical tools on
the back end. LEA also links your conditions, steps and analytical data together soyour final report doesn’t just have numbers, it’s got all the information you need tomake real decisions.

Library Studio
Design complex, high-throughput
experiments in an array-based format

PolyView
Review and report all info
from experimental design,
execution and analytics

Automation Studio
Execute designed experiments
and integrated analytics

Unchained Labs
6940 Koll Center Pkwy, Suite 200
Pleasanton, CA 94566
Phone: 1.925.587.9800
Toll-free: 1.800.815.6384
Email: info@unchainedlabs.com© 2016 Unchained Labs. All rights reserved. The
Unchained Labs logo and freeslate are trademarks
and/or registered trademarks of Unchained Labs.