What I learned at
MD Anderson Cancer CenterShowa University
Department of Breast Surgical Oncology

Hiroko Masuda MD.,PhD.

My Oncology Dream Award
New nationwide competition in Japanamong oncology professionals, for the opportunity to receive
high level research education at MD Anderson Cancer Center Can be a Postdoctoral fellow
 Can choose a Mentor
from MDACC’s professors(if they will accept)
 Can pursue
what we want to learn

Breast Medical Oncology

The Morgan Welch Inflammatory BreastCancer Research Program and Clinic
1. How can we distinguish IBC from non-IBC
at the molecular level that will lead to universal
diagnostic criteria?

2. What are the IBC unique etiologies that can be
developed as IBC-specific targets?
3. What are the risk factors for a development ofIBC?

Education System
Systemic and Logical Training•Mentor-Mentee System
・What we should learn and achieve to be an
academic leader(Clinician Investigator) at
oncology field.
・Guidance for Career Development

・Full Educational Workshops for postdoctoral
fellow・Presentation Skill
・Writing Skill
・Basic Knowledge

Goal for postdoctoral fellowship1.To write Review article
・Role of epidermal growth factor receptor in breast cancer.
Masuda H, Ueno NT et al. Breast Cancer Res Treat. 2012 Nov;136(2)2.To conduct retrospective study
・Statin use in primary inflammatory breast cancer: A cohort study
Masuda H, Brewer T, Ueno NT et al. Brit J cancer. 2013 July

・Long-term treatment efficacy in primary inflammatory breast cancer byhormonal receptor- and HER2-defined subtypes
Masuda H, Brewer T, Ueno NT et al. Annals of Oncol 2013

3.To perform Translation Research・Molecular subtype distribution in triple negative inflammatory and noninflammatory breast cancers. Masuda H, Ueno NT. Breast Cancer Res.
・Differential response to neoadjuvant chemotherapy among 7 triple
negative breast cancer molecular subtypes.
Masuda H, Ueno NT, et al. Clin Cancer Res. 2013 Oct 1;19(19)Goal for postdoctoral fellowship4.To conduct prospective study Phase II study of denosumab to define the role of bonerelated biomarkers in breast cancer bone metastasis
 Phase III study of Atorvastatin as Adjuvant therapy in patientswith inflammatory and Triple Negative breast cancer Improving Outcomes in Triple Negative Breast Cancer Using
Molecular Triaging and Diagnostic Imaging to Guide
Neoadjuvant Therapy

Summary・Research Environments
 Great and passionate Mentor
 Basic scientists
 Bioinformaticians Biostatisticians Huge clinical data Genomic data
 Friends who can mutually enhance one another・SPEED
 Can focus on only RESEARCH!!
 Can access developing drugs and technology

TexasSummary
2010 My Oncology Dream Award
2012 ASCO Travel Award
Met a future husband
2013 ASCO Bradley Stuart Beller Special Merit Award
Back to Japan
2014 Japan Breast Cancer Symposium; Invited Speaker
Got married
2015 Assistant professor at Showa University,
Department of Breast surgical oncology
Japan Breast Cancer Symposium; Invited Speaker
Young Investigator Award from JBCS
Had a baby girl2016 Japan Breast Cancer Symposium; Invited Speaker
Japanese cancer association; Invited SpeakerReceived a Grants in Aid for scientific research
Have a second baby

Acknowledgement
Primary Mentor
Naoto T Ueno, M.D., Ph.D.
The Morgan Welch Inflammatory
Breast Cancer Research Programand Clinic
Valero,Vicente, M.D.
Chandra Batholomeusz, M.D., PhD.
Alvarez,Ricardo Hugo, M.D.
James M. Reuben, Ph.D.
Wendy A. Woodward, M.D.,Ph.D.
Danielle M. Walsh, M.S
Jie S. Willey, RN, MSN.
Monica E. Reyes, B.S.
Kazuharu Kai, M.D., PhD.
Takahiro Kogawa, M.D., PhD.
Tamer Fouad, M.D., PhD.
Jangsoon Lee. Ph.D.
Xuemei Xie, Ph.D.
Xiaoping Wang, Ph.D.
Bedrich Eckhardt, M.D., PhD.
Angie M. Torres Adorno, B.S,
Kimie Kondo, M.S.
Ali Dadbin M.S.

Dept. of Breast Medical Oncology
Gabriel N. Hortobagyi, M.D.
Ana M. Gonzalez-Angulo, M.D.
Lajos Pusztai, M.D., Ph.D.
Amal Melhem-Bertrandt, M.D.
Limin Hsu, M.S
Dept. of Bioinformatics & Comp Biology
Keith A Baggerly, Ph.D.
Ying Wang, PhD
Dept. Of Pathology
Savitri Krishnamurthy, M.D.
W. Fraser Symmans, M.D.
Dept. of Biostatistics
Yu Shen, Ph.D.
Diane D Liu M.S.