平成28年度 業績【1】原著
Sato H, Kato H, Yamaza H, Masuda K, Nguyen HT, Pham TT, Han X, Hirofuji Y, Nonaka K. Engineering of Systematic Eliminationof a Targeted Chromosome in Human Cells. Biomed Res Int. 2017; 2017: 6037159. doi: 10.1155/2017/6037159
Takagi B, Hong T, Hynd ET, Fong SKK, Fogelgren B, Nonaka K, Lozanoff S. Reduction in Wnt9b and associated gene expression in
the embryonic midface of CL/Fr mice with heritable cleft lip and palate. Anatomy 2016;10(3):182–192
Fang J, Yamaza H, Uchiumi T, Hoshino Y, Masuda K, Hirofuji Y, Wagener FA, Kang D, Nonaka K. Dihydroorotate dehydrogenase
depletion hampers mitochondrial function and osteogenic differentiation in osteoblasts. Eur J Oral Sci. 2016 Jun;124(3):241-5.
Akabane S, Uno M, Tani N, Shimazaki S, Ebara N, Kato H, Kosako H, Oka T. PKA Regulates PINK1 Stability and Parkin
Recruitment to Damaged Mitochondria through Phosphorylation of MIC60. Mol. Cell. 2016, 62(3); 371-384
Tashiro, A., Shibata, S., Takai, Y., Uchiwa, T., Furuse, M., Yasuo, S. Changes in photoperiod alter Glut4 expression in skeletal muscle
of C57BL/6J mice. Biochemical and Biophysical Research Communications, 485, 82-88, 2017.
Kawase, T., Nagasawa, M., Ikeda, H., Yasuo, S., Koga, Y., Furuse, M. Gut microbiota of mice putatively modifies amino acidmetabolism in the host brain, British Journal of Nutrition, 117, 775-783, 2017.
Kodaira, M., Nagasawa, M., Yamaguchi, T., Ikeda, H., Minaminaka, K., Chowdhury, V.S., Yasuo, S., Furuse, M. Aging rather thanstress strongly influences amino acid metabolisms in the brain and genital organs of female mice, Mechanisms of Aging andDevelopment, 162, 72-79, 2017.
Ikeda, H., Nagasawa, M., Yamaguchi, T., Minaminaka, K., Goda, T., Chowdhury V.S., Yasuo, S., Furuse, M. Disparities in activity
levels and learning ability between Djungarian hamster (Phodopus sungorus) and Roborovskii hamster (Phodopus roborovskii),
Animal Science Journal, 88, 533-545, 2017.
Uchiwa, T., Takai, Y., Tashiro, A., Furuse, M., Yasuo, S. Exposure of C57BL/6J mice to long photoperiod during early life stages
increases body weight and alters plasma metabolomic profiles in adulthood, Physiological Reports, 4, e12974, 2016.
Morino-Koga S, Uchi H, Mitoma C, Wu Z, Kiyomatsu M, Fuyuno Y, Nagae K, Yasumatsu M, Suico MA, Kai H, Furue M.
6-formylindolo[3,2-b]carbazole (FICZ) accelerates skin wound healing via activation of ERK, but not aryl hydrocarbon receptor.
J Invest Dermatol. 2017 May 25. pii: S0022-202X(17)31557-9. doi: 10.1016/j.jid.2016.10.050. [Epub ahead of print]
Takeda T, Komiya Y, Koga T, Ishida T, Ishii Y, Kikuta Y, Nakaya M, Kurose H, Yokomizo T, Shimizu T, Uchi H, Furue M, Yamada H.
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity
owing to neutrophil infiltration. J Biol Chem. 2017 May 9. pii: jbc.M116.764332. doi: 10.1074/jbc.M116.764332.
Morokuma S, Tsukimori K, Hori T, Kato K, Furue M. The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus.
Sci Rep. 2017 Apr 7;7(1):739. doi: 10.1038/s41598-017-00863-9. PubMed PMID: 28389640;
Tsuji G, Hashimoto-Hachiya A, Takemura M, Kanemaru T, Ichihashi M, Furue M. Palladium and platinum nanoparticles activate
AHR and NRF2 in human keratinocytes-implications in vitiligo therapy. J Invest Dermatol. 2017 Mar 11. [Epub ahead of print]
Uchi H, Yasumatsu M, Morino-Koga S, Mitoma C, Furue M. Inhibition of aryl hydrocarbon receptor signaling and induction of
NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes. J Dermatol Sci. 2017 Jan;85(1):36-43.
Vu Thi Hanh, Yutaro Kobayashi Motohiro Maebuchi, Toshihiro Nakamori, Mitsuru Tanaka, Toshiro Matsui: Quantitative mass
spectrometric analysis of dipeptides in protein hydrolysate by a TNBS derivatization-aided standard addition method. Food Chem.,
190, 345-350 (2016).
Yusuke Ushida, Chutinan Boonyapichest, Hiroyuki Suganuma, Mitsuru Tanaka, Toshiro Matsui: Paracellular transport ofsulforaphane across Caco-2 cell monolayers. Food Sci. Technol. Res., 22(1), 127-134 (2016).
Jian Zhao, Aki Suyama, Hsuan Chung, Toshihiko Fukuda, Mitsuru Tanaka, Toshiro Matsui: Ferulic acid enhances nitric oxide
production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells. Life Sci., 145, 224-232(2016).

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Hirosuke Inoue, Hisanori Nishio, Hidetoshi Takada, Etsuro Nanishi, Yasunari Sakai, Masayuki Ochiai, Mitsuho Onimaru, Si Jing
Chen, Toshiro Matsui, and Toshiro Hara: Activation of Nod1 signaling induces fetal growth restriction and death through fetal andmaternal vasculopathy. J. Immunology, 196(6), 2779-2787 (2016).
Kazuki Moriyasu, Takashi Ichinose, Akane Nakahata, Mitsuru Tanaka, Toshiro Matsui and Shigeki Furuya: The dipeptides Ile-Tyr
and Ser-Tyr exert distinct effects on catecholamine metabolism in the mouse brainstem. Int. J. Peptides, 2016, 1-5 (2016).
Seong-Min Hong, Mitsuru Tanaka, Riho Koyanagi, Weilin Shen, and Toshiro Matsui: Structural design of oligopeptides for intestinal
transport model. J. Agric. Food Chem., 64(10), 2072-2079 (2016).
Thanutchaporn Kumrungsee, Sayaka Akiyama, Tomomi Saiki, Masao Omae, Kazuhiro Hamasawa, and Toshiro Matsui:
Vasorelaxation effect of 5’-methylthioadenosine obtained from Candida utilis yeast extract though the suppression of intracellular
Ca2+ concentration in rat isolated aorta. J. Agric. Food Chem., 64(17), 3362-3370 (2016).
Toshihiko Fukuda, Kaustav Majumder, Hua Zhang, Patricia V. Turner, Toshiro Matsui, and Yoshinori Mine: Adenine inhibits TNF-αsignaling in intestinal epithelial cells and reduces mucosal inflammation in a dextran sodium sulfate-induced colitis mouse model. J.
Agric. Food Chem., 64(21), 4227-4234 (2016).
Jian Guo, Naoto Hirasaki, Yuji Miyata, Kazunari Tanaka, Takashi Tanaka, Xiao Wu, Yusuke Tahara, Kiyoshi Toko, and Toshiro
Matsui: Evaluating the reduced hydrophobic taste sensor response of dipeptides by theasinensin A by using NMR and quantum
mechanical analyses. PLoS ONE, 11(6), e0157315 (2016).
Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Mai Hyoguchi, Satoshi Tajiri, Mitsuru Tanaka, Yoshinori Mine, and Toshiro
Matsui: Adenine attenuates the Ca2+ contraction-signaling pathway via adenine receptor-mediated signaling in rat vascular smoothmuscle cells. Naunyn-Schmiedeberg's Archives of Pharmacology, (Naunyn-Schmiedebergs Arch. Pharmacol.), 389(8), 999-1007(2016).
Thanutchaporn Kumrungsee, Sayaka Akiyama, Jian Guo, Mitsuru Tanaka, and Toshiro Matsui: Identification of peptides in wheat
germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity. Food Chem., 213(6), 329-335 (2016).
Huu-Nghi Nguyen, Mitsuru Tanaka, Genki Komabayashi, and Toshiro Matsui: The photobase generator nifedipine as a novel matrix
for the detection of polyphenols in matrix-assisted laser desorption/ionization mass spectrometry. J. Mass Spectr., 51(10), 748-756(2016).
Akiko Mizokami, DaGuang Wang, Mitsuru Tanaka, Jing Gao, Hiroshi Takeuchi, Toshiro Matsui, and Masato Hirata: An extract frompork bones containing osteocalcin improves glucose metabolism in mice by oral administration. Biosci. Biotechnol. Biochem.,
80(11), 2176-2183 (2016).
Kawai K, Nakashima M, Kojima M, Yamashita S, Takakura S, Shimizu M, Kubo C, Sudo N. Ghrelin activation and neuropeptide Y
elevation in response to medium chain triglyceride administration in anorexia nervosa patients. Clin Nutr ESPEN. 2017
Feb;17:100-104.
Rooks MG, Veiga P, Reeves AZ, Lavoie S, Yasuda K, Asano Y, Yoshihara K, Michaud M, Wardwell-Scott L, Gallini CA, Glickman
JN, Sudo N, Huttenhower C, Lesser CF, Garrett WS. QseC inhibition as an antivirulence approach for colitis-associated bacteria.
Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):142-147.
Hayaki C, Anno K, Shibata M, Iwaki R, Kawata H, Sudo N, Hosoi M. Family dysfunction: A comparison of chronic widespread pain
and chronic localized pain. Medicine (Baltimore). 2016 Dec;95(49):e5495.
Furukawa T, Nakano H, Yoshihara K, Sudo N. The Relationship between Snoring Sound Intensity and Morning Blood Pressure in
Workers. J Clin Sleep Med. 2016 Dec 15;12(12):1601-1606.
Koga Y, Tokunaga S, Nagano J, Sato F, Konishi K, Tochio T, Murakami Y, Masumoto N, Tezuka JI, Sudo N, Kubo C, Shibata R.
Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants. Pediatr Res. 2016
Dec;80(6):844-851.
Sawamoto R, Nagano J, Kajiwara E, Sonoda J, Hiramoto T, Sudo N. Inhibition of emotional needs and emotional wellbeing predict
disease progression of chronic hepatitis C patients: an 8-year prospective study. Biopsychosoc Med. 2016 Jul 29;10:24.
Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M. Perceived inadequate2care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood: the Hisayama
Study. BMC Psychiatry. 2016 Jul 7;16:215.
Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N,
Kiyohara Y, Ninomiya T. Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study.
Diabetes Care. 2016 Sep;39(9):1543-9.
Yoshihara K, Tanabe HC, Kawamichi H, Koike T, Yamazaki M, Sudo N, Sadato N. Neural correlates of fear-induced sympathetic
response associated with the peripheral temperature change rate. Neuroimage. 2016 Jul 1;134:522-31.
H. Einaga, and A. Kiya, “Effect of Aging on CO Oxidation Properties of Copper Manganese Oxides Prepared byHydrolysis-Coprecipitation using Tetramethyl Ammonium Hydroxide”, React. Kin. Mech. Catal., 114, pp.409-420 (2016).
C. Lee, Y. Jeon, S. Hata, J.-I. Park, R. Akiyoshi, H. Saito, Y. Teraoka, Y.-G. Shul, and H. Einaga, “Three-dimensional Arrangementsof Perovskite-type Oxide Nano-fiber Webs for Effective Soot Oxidation”, Appl. Catal. B: Environ., 191, pp.157-164 (2016).
K. Taira, K. Nakao, K. Suzuki, H. Einaga, “SOx tolerant Pt/TiO2 catalysts for CO oxidation and the effect of TiO2 supports on
catalytic activity”, Environ. Sci. Technol. 50, pp.9773-9780 (2016).
H. Einaga, W. Yoshida, K. Kusaba, “Catalytic Properties of CeO2-Supported LaMnO3 for NO Oxidation”, Catal. Lett., 146, pp.
2495-2503 (2016).
Onozuka D, Hagihara A. Spatial and temporal variation in emergency transport during periods of extreme heat in Japan: A
nationwide study. Science of the Total Environment 2016; 544:220–229.
Onozuka D, Hagihara A. All-cause and cause-specific risk of emergency transport attributable to temperature: A nationwide study.
Medicine 2015; 94(51):e2259.
Shibuta H, Abe T, Miyamoto H, Hagihara A. Interaction effects of rehabilitation and social resources use after hospital discharge on
patients’ functional abilities. Journal of Rehabilitation Medicine 2016; 48: 307–315.
Onozuka D, Hagihara A, Nishimura K, Kada A, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I,
Toyoda K, Matsuda S, Suzuki A, Kataoka H, Nakamura F, Kamitani S, Nishimura A, Kurogi R, Sayama T, Iihara K, the J-ASPECT
Study Collaborators. Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya
disease: a nationwide retrospective cohort study (J-ASPECT study) BMJ Open 2016;6:e009942 doi:10.1136/bmjopen-2015-009942.
Hagihara A, Onozuka D, Hasegawa M, Nagata T, Abe T, Nabeshima Y. Resuscitation outcomes of reproductive-age females who
experienced out-of-hospital cardiac arrest. European Heart Journal: Acute Cardiovascular Care 2016; 1-9. DOI:
10.1177/2048872616633879.
Ichiki T, Onozuka D, KamouchiM, Hagihara A. Fine particulate matter (PM2.5) level does not affect emergency ambulancedispatches for cardiovascular diseases in Japan. International Archives of Occupational and Environmental Health 2016;
89:1329-1335.
Onozuka D, Hagihara A. Associations of day-to-day temperature change and diurnal temperature range with out-of-hospital cardiac
arrest. European Journal of Preventive Cardiology. 2017; 24:204-212.
Onozuka D, Hagihara A. Extreme temperature and out-of-hospital cardiac arrest in Japan: A nationwide, retrospective, observational
study. Science of the Total Environment. 2017; 575:258-264.
Onozuka D, Hagihara A. Out-of-hospital cardiac arrest attributable to sunshine: A nationwide, retrospective, observational study.
European Heart Journal - Quality of Care and Clinical Outcomes 2017; 3(2): 107-113.
Onozuka D, Hagihara A. Out-of-hospitalcardiac arrest attributable to temperature: A nationwide, retrospective, observational study.
Scientific reports 7, 39538, 2017.01.
Sozo Inoue, Naonori Ueda, Yasunobu Nohara, Naoki Nakashima. Recognizing and Understanding Nursing Activities for a Whole
Day with a Big Dataset. Journal of Information Processing. 24(6). 853-866. 2016.

3

Masayuki Ochiai, Yuki Matsushita, Hirosuke Inoue, Takeshi Kusuda, Dongchon Kang, Kiyoshi Ichihara, Naoki Nakashima, Koji
Iihara, Shouichi Ohga, Toshiro Hara. Kyushu University High-Risk Neonatal Clinical Research Network. Blood Reference Intervals
for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan. PLoS One. 2016.
Koji Tanaka, Takeshi Yamada, Takako Torii, Shoji Matsumoto, Takeo Yoshimura, Kei-ichiro Takase, Yoshifumi Wakata, Naoki
Nakashima, Jun-ichi Kira, Hiroyuki Murai. Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial
Fibrillation-Related Cardioembolic Stroke. European Neurology. 76(3-4):105-111. 2016.
野原 康伸, 井上 創造, 磯田 達也, 白水 麻子, 杉山 康彦, 瀬高 香澄, 前崎 元美, 中島 直樹. センサネットワークを用いた急性期病棟の包括的行動センシングによる看護師業務改善. 第20回日本医療情報学会春季学術大会抄録集. 68-69.
2016.
Koji Tanaka, Takeshi Yamada, Takako Torii, Shoji Matsumoto, Takeo Yoshimura, Kei-ichiro Takase, Yoshifumi Wakata, Naoki
Nakashima, Jun-ichi Kira, Hiroyuki Murai. Clinical Characteristics of Atrial Fibrillation-Related Cardioembolic Stroke in Patients
Aged 80years or Older. Geriatrics & Gerontology International. 1-6. 2016.
南雲 文夫, 藤井 進, 野中 小百合, 堀田 多恵子, 中島 直樹, 末岡 榮三郎, 康 東天. 容易・正確・効率的なJLAC10マッ
ピングツールとして体外診断用医薬品承認番号利用の有効性 .第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 970-973. 2016.
Koutarou Matsumoto, Yasunobu Nohara, Yoshifumi Wakata, Takanori Yamashita, Naoki Nakashima. Exploratory Data Analysis of
Clinical Pathway for Brain Hemorrhage Using Machine Learning Technique. The 17th China-Japan-Korea Joint Symposium on
Medical Informatics (CJKMI2016) Proceedings. 50-53. 2016.
藤井 進, 野中 小百合, 南雲 文夫, 堀田 多恵子, 末岡 榮三郎, 中島 直樹, 康 東天. 統合解析可能な大規模医療情報データベース構築と維持における、JLAC10自動マッピングツールの作成と性能評価. 第36回医療情報学連合大会(第17回日
本医療情報学会学術大会)論文集. 512-515. 2016.
木村 通男, 渡辺 浩, 澤 智博, 作佐部 太也, 中島 直樹. 証拠性のある医学研究 Web型小病院向け電子カルテシステムを用いた研究ノートの電子化. 第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 722-723. 2016.
作佐部 太也, 大内 雄矢, 澤 智博, 渡辺 浩, 中島 直樹, 木村 通男. 証拠性のある医学研究 次世代シーケンサーからのデータの証拠性確保における暗号技術の利用についての評価と提案. 第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 720-721. 2016.
中島 直樹, 植木 浩二郎, 美代 賢吾, 興梠 貴英, 森永 裕, 谷 祐児. J-DREAMSなどの疾患コホート研究の意義と医療情報部門の役割. 第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 38-41. 2016.
白鳥 義宗, 中島 直樹, 町田 二郎, 河村 進, 岡峯 栄子, 井川 澄人. 電子パス標準化の方向性. 第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 64-67. 2016.
安徳 恭彰, 若田 好史, 行実 史子, 錦谷 まりこ, 德永 章二, 中島 直樹. 汎用型臨床研究データ収集システムの比較研究.
第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 284-287. 2016.
山本 陵平, 新澤 真紀, 守山 敏樹, 猪阪 善隆, 杉山 斉, 丸山 彰一, 中島 直樹, 岡田 浩一, 岡田 美保子, 柏原 直樹. コ
ホート研究を目的とした情報処理システム：コホートメーカー. 第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 544-545. 2016.
松本 晃太郎, 野原 康伸, 若田 好史, 山下 貴範, 牟田 大助, 西 徹, 中熊 英貴, 小妻 幸男, 甲斐 聖人, 町田 二郎, 副島秀久, 中島 直樹. 機械学習を用いた探索的なクリニカルパス分析. 第36回医療情報学連合大会(第17回日本医療情報学会
学術大会)論文集. 556-559. 2016.
中島 直樹, 渡辺 浩, 澤 智博, 作佐部 太也, 宇山 佳明, 山口 光峰, 木村 通男. 証拠性のある医学研究 病院情報シス
テムからのEDCデータ源に関する検討. 第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 714-717.
2016.
澤 智博, 渡辺 浩, 作佐部 太也, 中島 直樹, 木村 通男. 証拠性のある医学研究 次世代シーケンサー等のデータソース
および解析ソフトウエアの検討. 第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 718-719. 2016.

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伊豆倉 理江子, 山下 貴範, 野尻 千夏, 野原 康伸, 中島 直樹. MID-NET事業成果報告：医薬品曝露に伴う有害事象の発現に関するスクリプト検討.第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集. 784-787. 2016.
藤井 進, 野中 小百合, 南雲 文夫, 堀田 多恵子, 末岡 榮三郎, 中島 直樹, 康 東天. パターンIDと患者IDから生成する統合ID(自動名寄技術)の個人を特定する能力評価と、それを用いた施設間の連結がもたらす大規模医療情報データベース
における経時性や網羅性に対する有用性の評価. 第36回医療情報学連合大会(第17回日本医療情報学会学術大会)論文集.
1122-1125. 2016.
野原 康伸, 松本 晃太郎, 中島 直樹. 機械学習手法を用いた脳梗塞の予後予測因子の抽出. 第3回医療情報学会・人工知能学会AIM合同研究会抄録集. 01-06. 2016.
Naoya Onimura, Takanori Yamashita, Naoki Nakashima, Hidehisa Soejima, Sachio Hirokawa. Generation of Sentence Template
Graph from SOAP Format Medical Documents. Proceedings of CSCI2016. **-**. 2016. (to appear)
Takanori Yamashita, Yoshifumi Wakata, Hidehisa Soejima, Naoki Nakashima, Sachio Hirokawa. Prediction of Key Patient Outcome
from Sentence and Word of Medical Text Records, Proceedings of Clinical Natural Language Processing Workshop at
COLING2016. 86-90. 2016
Takanori Yamashita, Yoshifumi Wakata, Hidehisa Soejima, Naoki Nakashima, Sachio Hirokawa. Structuralization of Variance Text
Records in Clinical Pathway. Proceedings of APAMI2016. 85. 2016.
Nakayama, J., Yamamoto, A., Palermo-Conde, L. A., Higashi, K., Sonomoto, K. Tan, J., Lee, Y. K.
Impact of westernized diet on gut microbiota in children on Leyte island
Frontiers in Microbiology, 8, 197, 1-18
Yanagi Y, Matsuura T, Hayashida M, Takahashi Y, Yoshimaru K, Esumi G, Taguchi T.
Bowel perforation after liver transplantation for biliary atresia: a retrospective study of care in the transition from children to
adulthood.
Pediatr Surg Int. 33(2):155-163, 2017
Mochizuki K, Hayakawa M, Urushihara N, Miyake H, Yokoi A, Shiraishi J, Fujinaga H, Ohashi K, Esumi G, Ohfuji S, Amae S,
Yanai T, Furukawa T, Tazuke Y, Minagawa K, Okuyama H.
Timing and outcome of stoma closure in very low birth weight infants with surgical intestinal disorders.
Surg Today. [Epub ahead of print], 2017
Matsuura T, Yoshimaru K, Yanagi Y, Esumi G, Hayashida M, Taguchi T.
Insufficient portal vein inflow in children without major shunt vessels during living donor liver transplantation.
Ann Transplant. 21:373-379, 2016
Satoh S, Takatori A, Ogura A, Kohashi K, Souzaki R, Kinoshita Y, Taguchi T, Hossain MS, Ohira M, Nakamura Y, Nakagawara A.
Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma.
Sci Rep.
6:32682, 2016
Yoshimaru K, Kinoshita Y, Matsuura T, Esumi G, Wada M, Takahashi Y, Yanagi Y, Hayashida M, Ieiri S, Taguchi T.
Clinical analysis of 70 bowel obstruction cases without a history of laparotomy.
Pediatr Int. 58: 1205-1210, 2016
Kuda M, Kohashi K, Yamada Y, Maekawa A, Kinoshita Y, Nakatsura T, Iwamoto Y, Taguchi T, Oda Y.
FOXM1 expression in rhabdomyosarcoma: a novel prognostic factor and therapeutic target.
Tumour Biol. 37(4):5213-23, 2016
髙橋良彰、伊崎智子、飯田則利.
小児卵巣腫瘍30例の検討.
日小外会誌. 52(6)：1157-62.2016
Jimbo T, Ieiri S, Obata S, Uemura M, Souzaki R, Matsuoka N, Katayama T, Masumoto K, Hashizume M, Taguchi T.
A new innovative laparoscopic fundoplication training simulator with a surgical skill validation system.
Surg Endosc.Aug. 12, 2016
Yoshimaru K, Matsuura T, Hayashida M, Kinoshita Y, Takahashi Y, Yanagi Y, Esumi G, Taguchi T.

5Transient hyperphosphatasemia after pediatric liver transplantation.
Pediatr Int. 58(8):726-31, 2016
Takayasu H, Masumoto K, Goishi K, Hayakawa M, Tazuke Y, Yokoi A, Terui K, Okuyama H, Usui N, Nagata K, Taguchi T.
Musculoskeletal abnormalities in congenital diaphragmatic hernia survivors: Patterns and risk factors: report of a Japanesemulticenter follow-up survey.
Pediatr Int. 58(9):877-80, 2016
Jimbo T, Ieiri S, Obata S, Uemura M, Souzaki R, Matsuoka N, Katayama T, Masumoto K, Hashizume M, Taguchi T.
Preoperative simulation regarding the appropriate port location for laparoscopic hepaticojejunostomy: a randomized study using a
disease-specific training simulator.
Pediatr Surg Int. 32(9):901-7, 2016
Kohashi K, Tanaka Y, Kishimoto H, Yamamoto H, Yamada Y, Taguchi T, Iwamoto Y, Oda Y.
Reclassification of rhabdoid tumor and pediatric undifferentiated/unclassified sarcoma with complete loss of SMARCB1/INI1
protein expression: three subtypes of rhabdoid tumor according to their histological features.
Mod Pathol. 29(10):1232-42,2016
Koreeda Y, Kobayashi Y, Ieiri S, Nishio Y, Kawamura K, Obata S, Souzaki R, Hashizume M, Fujie MG.
Virtually transparent surgical instruments in endoscopic surgery with augmentation of obscured regions.
Int J Comput Assist Radiol Surg. 11(10):1927-36,2016
Yoshimaru K, Wada M, Esumi G, Takahashi Y, Yanagi Y, Hayashida M, Matsuura T, Ieiri S, Kinoshita Y, Taguchi T.
Clinical analysis of 76 bowel obstruction cases without a history of laparotomy.
Pediatrics International. 58(11):1205-1210, 2016
Matsuura T, Takahashi Y, Yanagi Y, Yoshimaru K, Yamamura K, Morihana E, Nagata H, Uike K, Takada H, Taguchi T.
Surgical strategy according to the anatomical types of congenital portosystemic shunts in children.
J Pediatr Surg.51(12):2099-2104, 2016
Takahashi Y, Matsuura T, Yanagi Y, Yoshimaru K, Taguchi T.
The role of splenectomy before liver transplantation in biliary atresia patients.
J Pediatr Surg.51(12):2095-2098. 2016
赤星朋比古, 池田哲夫, 富川盛雅, 宗崎良太, 橋爪 誠.
病的肥満症に対する減量手術のメタボリック症候群に対する治療効果.
九州臨床外科医学会々誌. 1(2):14-20,2016
木下義晶、貝沼茂三郎、永田公二、宮田潤子、家入里志、田口智章.
遺糞症に対するpull through術後に生じた便失禁に対する補中益気湯の応用
小児外科. 48(7):705-707, 2016.

Takada H, Ishimura M, Hara T:
Insufficient immune reconstitution after allogeneic cord blood transplantation without chemotherapy conditioning in patients with
SCID caused by CD3δ deficiency.
Bone Marrow Transplant 51(8):1131-3, 2016
Yamamoto H, Ishimura M, Ochiai M, Takada H, Kusuhara K, Nakatsu Y, Tsuzuki T, Mitani K, Hara T:
BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector.
Gene Ther 23(2):205-13, 2016
Ikeda F, Yoshida K, Toki T, Uechi T, Ishida S, Nakajima Y, Sasahara Y, Okuno Y, Kanezaki R, Terui K, Kamio T, Kobayashi A,
Fujita T, Sato-Otsubo A, Shiraishi Y, Tanaka H, Chiba K, Muramatsu H, Kanno H, Ohga S, Ohara A, Kojima S, Kenmochi N,
Miyano S, Ogawa S, Ito E:
Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia.
Haematologica Dec 1. pii: haematol, 2016.153932 (Epub ahead of print)
Ichimura T, Yoshida K, Yosuke O, Yujiri T, Nagai K, Nishi M, Shiraishi Y, Hiroo U, Toki T, Azuma Y, Chiba K, Tanaka H,
Muramatsu H, Ogawa S, Tanizawa Y, Hara T, Kanno H, Kojima S, Miyano S, Ito E, Ogawa S, Ohga S:
Diagnostic challenge of Diamond-Blackfan anemia in mothers and children by whole-exome sequencing.

6Int J Hematol Nov 23, 2016 (Epub ahead of print)
Nishikawa E, Yagasaki H, Hama A, Yabe H, Ohara A, Kosaka Y, Kudo K, Kobayashi R, Ohga S, Morimoto A, Watanabe KI,
Yoshida N, Muramatsu H, Takahashi Y, Kojima S:
Long-term outcomes of 95 children with moderate aplastic anemia treated with horse antithymocyte globulin and cyclosporine.
Pediatr Blood Cancer Nov 3, 2016 (Epub ahead of print)
Hoshino A, Okada S, Yoshida K, Nishida N, Okuno Y, Yamashita M, Okano T, Tsumura M, Nishimura S, Sakata S, Nakamura H,
Kamizono J, Ichimura T, Ohga S, Nakazawa Y, Takagi M, Imai K, Ueno H, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S,
Kojima S, Nonoyama S, Morio T & Kanegane H:
Abnormal hematopoiesis and autoimmunity in humans with germline IKZF1 mutations.
J Allergy Clin Immunol Dec 1. pii: S0091-6749(16)31273-8, 2016 (Epub ahead of print)
Yamazaki T, Shibuya A, Ishii S, Miura N, Araki R, Ohta Y, Fujiwara M, Miyajima Y, Uetake K, Hamahata K, Kato K, Kawakami K,
Toyoda H, Moriguchi N, Okada M, Nishi M, Ogata Y, Takimoto T, Ohga S, Ohta S, Amemiya S:
High-dose cepharantine therapy for pediatric chronic immune thrombocytopenia.
Pediatr Int Sep 6. doi: 10.1111/ped.13151, 2016 (Epub ahead of print)
Muramatsu H, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K,
Tanaka H, Hama A, Sanada M, Takahashi Y, Kanno H, Yamaguchi H, Ohga S, Manabe A, Harigae H, Kunishima S, Ishii E,
Kobayashi M, Koike K, Watanabe K, Ito E, Takata M, Yabe M, Ogawa S, Miyano S, Kojima S:
Clinical application of capture-based target sequencing for inherited bone marrow failure syndromes.
Genet Med 2016 (in press)
Sekiya Y, Shimada A, Imamura T, Ohga S, Ohtsuka K, Hasegawa D, Fujisaki H, Kosaka Y, Kawasima N, OkunoY, Oh K, Jo K,
Narita A, Sunami K, Kojima S:
JAK2, MPL, and CALR mutations in children with essential thrombocythemia.
Int J Hematol 104(2):266-7, 2016
Utsugisawa T, Uchiyama T, Toki T, Ogura H, Aoki T, Hamaguchi I, Ishiguro A, Ohara, Kojima S, Ohga S, Ito E, Kanno H:
Erythrocyte Reduced Glutathione is a Novel Biomarker of Diamond-Blackfan Anemia.
Blood Cell Mol Dis 59:31-6, 2016
Kibata T, Suzuki Y, Hasegawa S, Matsushige T, Kusuda T, Kajimoto M, Takahashi K, Okada S, Wakiguchi H, Moriwake T, Uchida
M, Ohbuchi N, Iwai T, Hasegawa M, Ichihara K, Yashiro M, Makino N, Nakamura Y, Ohga S:
Coronary artery lesions and the increasing incidence of Kawasaki disease resistant to initial immunoglobulin therapy.
Int J Cardiol 214:209-15, 2016
Arashiki N, Takakuwa Y, Mohandas N, Hale J, Yoshida K, Ogura H, Utsugisawa T, Ohga S, Miyano S, Ogawa S, Kojima S, Kanno
H:
ATP11C encodes a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia.
Haematologica 101(5):559-65, 2016
Kagawa R, Fujiki R, Tsumura M, Sakata S, Nishimura S, Itan Y, Kong XF, Kato Z, Ohnishi H, Hirata O, Saito S, Ikeda M, Baghdadi
JE, Bousfiha A, Fujiwara K, Oleastro M, Yancoski J, Perez L, Danielian, PhD S, Aillal F, Takada H, Hara T, Boisson-Dupuis S,
Bustamante J, Casanova JL, Ohara O, Okada S, Kobayashi M:
Alanine-scanning mutagenesis of human STAT1 to estimate loss- or gain-of-function variants.
J Allergy Clin Immunol (in press)
Hori M, Yasumi T, Shimodera S, Shibata H, Hiejima E, Oda H, Izawa K, Kawai T, Ishimura M, Nakano N, Shirakawa R,
Nishikomori R, Takada H, Morita S, Horiuchi H, Ohara O, Ishii E, Heike T:
A CD57+ CTL Degranulation Assay Effectively Identifies Familial Hemophagocytic Lymphohistiocytosis Type 3 Patients.
J Clin Immunol, 2016 (Epub ahead of print)
Ueki M, Yamada M, Ito K, Tozawa Y, Morino S, Horikoshi Y, Takada H, Abdrabou SS, Takezaki S, Kobayashi I, Ariga T:
A heterozygous dominant-negative mutation in the coiled-coil domain of STAT1 is the cause of autosomal-dominant Mendelian
susceptibility to mycobacterial diseases.
Clin Immunol 14;174:24-31, 2016
Cui L, Takada H, Takimoto T, Fujiyoshi J, Ishimura M, Hara T:

7

Immunoregulatory function of neonatal nucleated red blood cells in humans.
Immunobiology 221(8):853-61, 2016
Toda N, Hoshina T, Koga Y, Ochiai M, Kaku N, Yamamura K, Torisu H, Ihara K, Takada H, Maehara Y, Hara T:
Analysis of Death Due to Infectious Diseases in Patients Hospitalized in the Pediatric Ward of a Single Japanese Tertiary Medical
Facility.
Jpn J Infect Dis 69:464-70, 2016
Toda N, Ihara K, Kojima-Ishii K, Ochiai M, Ohkubo K, Kawamoto Y, Kohno Y, Kumasaka S, Kawase A, Ueno Y, Futatani T,
Miyazawa T, Nagaoki Y, Nakata S, Misaki M, Arai H, Kawai M, Sato M, Yada Y, Takahashi N, Komatsu A, Kanemasa M, Watabe
S, Sumida Y, Kuwashima M, Mizumoto H, Sato K, Hara T:
Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann, Sotos and Kabuki syndromes: A nationwide survey in Japan.
Am J Med Genet A 2016 (in press)
Narumi S, Amano N, Ishii T, Katsumata N, Muroya K, Adachi M, Toyoshima K, Tanaka Y, Fukuzawa R, Miyako K, Kinjo S, Ohga
S, Ihara K, Inoue H, Kinjo T, Hara T, Kohno M, Yamada S, Urano H, Kitagawa Y, Tsugawa K, Higa A, Miyawaki M, Okutani T,
Kizaki Z, Hamada H, Kihara M, Shiga K, Yamaguchi T, Kenmochi M, Kitajima H, Fukami M, Shimizu A, Kudoh J, Shibata S,
Okano H, Miyake N, Matsumoto N, Hasegawa T:
SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7.
Nat Genet 48(7):792-97, 2016
Lee S, Sanefuji M, Torio M, Kaku N, Ichimiya Y, Mizuguchi S, Baba H, Sakai Y, Ishizaki Y, Torisu H, Kira R, Hara T, Ohga S:
Involuntary movements and coma as the prognostic marker for acute encephalopathy with biphasic seizures and late reduced
diffusion.
J Neuro Sci 370:39-43, 2016
Sanefuji M, Craig M, Parlatini V, Mehta MA, Murphy DG, Catani M, Cerliani L, Thiebaut de Schotten M:
Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A
resting-state functional connectivity study.
Cortex 2016 (in press)
Sakai Y, Fukai R, Matsushita Y, Miyake N, Saitsu H, Akamine S, Torio M, Sasazuki M, Ishizaki Y, Sanefuji M, Torisu H, Shaw CA,
Matsumoto N, Hara T:
De novo truncating mutation of TRIM8 causes early-onset epileptic encephalopathy.
Ann Hum Genet 80:235-40, 2016 (Cover of this issue)
Morokuma S, Shimokawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Senju A, Kawamoto T, Kusuhara K; Japan Environment &Children’s Study Group:
Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment andChildren's Study (JECS).
BMC Pregnancy Childbirth 16:247, 2016
Abe Y, Sakai T, Okumura A, Akaboshi S, Fukuda M, Haginoya K, Hamano S, Hirano K, Kikuchi K, Kubota M, Lee S, Maegaki Y,
Sanefuji M, Shimozato S, Suzuki M, Suzuki Y, Takahashi M, Watanabe K, Mizuguchi M, Yamanouchi H:
Manifestations and characteristics of congenital adrenal hyperplasia-associated encephalopathy.
Brain Dev 38:638-47, 2016
Hoshina T, Ohga S, Fujiyoshi J, Nanishi E, Takimoto T, Kanno S, Nishio H, Saito M, Akeda Y, Oishi K, Hara T:
Memory B cell pools predict the immune response to pneumococcal conjugate vaccine in immunocompromised children.
J Infect Dis 216:848-55, 2016
Nanishi E, Hoshina T, Takada H, Ishimura M, Nishio H, Uehara T, Mizuno Y, Hasegawa S, Ohga S, Nagao M, Igarashi M, Yajima S,
Kusumoto Y, Onishi N, Sasahara Y, Yasumi T, Heike T, Hara T:
PID-Infection Study Group. A nationwide survey of common viral infections in childhood among patients with primary
immunodeficiency diseases.
J Infect 73:358-68, 2016
Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A,
Takada H, Hara T:

8

Hyperactive mTOR signals in the proopiomelanocortin-expressinghippocampal neurons cause age-dependent epilepsy and premature
death in mice.
Sci Rep 6:22991, 2016
Ochiai M, Matsushita Y, Inoue H, Kusuda T, Kang D, Ichihara K, Nakashima N, Ihara K, Ohga S, Hara T:
Kyushu University High-Risk Neonatal Clinical Research Network, Japan.
Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan.
PLoS One 11(8):e0161439, 2016
Ochiai M, Kurata H, Inoue H, Tanaka K, Matsushita Y, Fujiyoshi J, Wakata Y, Kato K, Taguchi T, Takada H:
An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis andBronchopulmonary Dysplasia in Erythropoietin-Treated Very-Low-Birth-Weight Infants.
Neonatology 111(1):68-75, 2016
Inoue H, Nishio H, Takada H, Sakai Y, Nanishi E, Ochiai M, Onimaru M, Chen SJ, Matsui T, Hara T:
Activation of Nod1 Signaling Induces Fetal Growth Restriction and Death through Fetal and Maternal Vasculopathy.
J Immunol 196(6):2779-87, 2016
Ichiyama M, Ohga S, Ochiai M, Tanaka K, Matsunaga Y, Kusuda T, Inoue H, Ishimura M, Takimoto T, Koga Y, Hotta T, Kang D,
Hara T:Age-specific onset and distribution of the natural anticoagulant deficiency in pediatric thromboembolism.
Pediatr Res 79:81-6, 2016
Hashiguchi K, Morioka T, Murakami N, Togao O, Hiwatashi A, Ochiai M, Eriguchi G, Kishimoto J, Iihara K:
Sequential morphological change of Chiari malformation type II following surgical repair of myelomeningocele.
Childs Nerv Syst 32(6):1069-78, 2016
Onouchi Y, Fukazawa R, Yamamura K, Suzuki H, Kakimoto N, Suenaga T, Takeuchi T, Hamada H, Honda T, Yasukawa K, Terai
M, Ebata R, Higashi K, Saji T, Kemmotsu Y, Takatsuki S, Ouchi K, Kishi F, Yoshikawa T, Nagai T, Hamamoto K, Sato Y, Honda A,
Kobayashi H, Sato J, Shibuta S, Miyawaki M, Oishi K, Yamaga H, Aoyagi N, Yoshiyama M, Miyashita R, Murata Y, Fujino A,
Ozaki K, Kawasaki T, Abe J, Seki M, Kobayashi T, Arakawa H, Ogawa S, Hara T, Hata A, Tanaka T:
Variations in ORAI1 Gene Associated with Kawasaki Disease.
PLoS One 11(1):e0145486, 2016
Yamasaki Y, Nagao M, Kamitani T, Yamanouchi T, Kawanami S, Yamamura K, Sakamoto I, Yabuuchi H, Honda H:
Clinical impact of left ventricular eccentricity index using cardiac MRI in assessment of right ventricular hemodynamics andmyocardial fibrosis in congenital heart disease.
Eur Radiol 26(10):3617-25, 2016
Yamasaki Y, Nagao M, Kawanami S, Kamitani T, Sagiyama K, Yamanouchi T, Sakamoto I, Yamamura K, Yabuuchi H, Honda H:
One-stop shop assessment for atrial septal defect closure using 256-slice coronary CT angiography.
Eur Radiol 2016 (Epub ahead of print)
Matsuura T, Takahashi Y, Yanagi Y, Yoshimaru K, Yamamura K, Morihana E, Nagata H, Uike K, Takada H, Taguchi T:
Surgical strategy according to the anatomical types of congenital portosystemic shunts in children.
J Pediatr Surg 2016 (Epub ahead of print)
Ito N, Hataya H, Saida K, Amano Y, Hidaka Y, Motoyoshi Y, Ohta T, Yoshida Y, Terano C, Iwasa T, Kubota W, Takada H, Hara T,
Fujimura Y, Ito S:
Efficacy and safety of eculizumab in childhood atypical hemolytic uremic syndrome in Japan.
Clin Exp Nephrol 20(2):265-72, 2016
Fukushima K, Morokuma S, Kitadai Y, Tazaki Y, Sumie M, Nakanami N, Ushiro S, Matsuda Y, Tsukimori K
Analysis of antenatal-onset cerebral palsy secondary to transient ischemia in utero using a national database in Japan.
J Obstet Gynaecol Res. 2016 Oct;42(10):1297-1303.
Michikawa T, Morokuma S, Fukushima K, Ueda K, Takeuchi A, Kato K, Nitta H.
Exposure to air pollutants during the early weeks of pregnancy, and placenta praevia and placenta accreta in the western part of Japan
Environ Int. 2016 May 7;92-93:464-470. doi: 10.1016/j.envint.2016.04.037.

9

Morokuma S, Shimokawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Senju A,
Kawamoto T, Kusuhara K; Japan Environment & Children’s Study Group.
Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment andChildren's Study (JECS).
BMC Pregnancy Childbirth. 2016 Aug 26;16:247.
Michikawa T, Morokuma S, Yamazaki S, Fukushima K, Kato K, Nitta H.
Air pollutant exposure within a few days of delivery, and placental abruption in Japan
Epidemiology. 28(2):190-196, March 2017.
Okawa H, Morokuma S, Maehara K, Horinouchi T, Arata A, Konishi Y, Kato K.
Eye movement activity in normal human fetuses between 24 and 39 weeks of gestation
Plos one. 2017 (in press)
Morokuma S, Tsukimori K, Hori T, Kato K, Furue M.
Vernix caseosa is the main site of dioxin excretion in human fetuses
Sci Rep. 2017 Apr 7;7(1):739. doi: 10.1038/s41598-017-00863-9.
光武玲子, 長谷川泰代, 荒田弘樹, 上野ふじ美, 新小田春美, 諸隈誠一
NICU・GCUの低出生体重児における音楽暴露時の生理的影響とアクチグラフによる身体活動量・睡眠の質についての検討
日本新生児学会雑誌. Vol.23, No.1, Apr. p16-22, 2017.
Andrew Stickley, Yoshiyuki Tachibana, Keiji Hashimoto, Hideyuki Haraguchi,
Atsuko Miyake, Seiichi Morokuma, Hiroshi Nitta, Masako Oda, Yukihiro Ohya, Ayako Senju, Hidetoshi Takahashi, Takanori
Yamagata, and Yoko Kamio
Assessment of autistic symptoms in children aged 2 to 4½ years with the preschool version of the Social Responsiveness Scale(SRS-P): findings from Japan
Autism Research 2017 Mar 3. doi: 10.1002/aur.1742.
Mayumi Tsuji, Tadayuki Ayabe, Rie Tanaka, Ayako Senju, Eiji Shibata, Shunsuke Araki,Seiichi Morokuma, Masafumi Sanefuji, Koichi Kusuhara, Toshihiro Kawamoto.
Comparative study on three different methods for arm-span measurement: the Japan Environment and Children's Study Pilot
Environmental Health and Preventive Medicine 2017 22:28 DOI 10.1186/s12199-017-0632-9
Iwata S, Fujita F, Kinoshita M, Unno M, Horinouchi T, Morokuma S, Iwata O.
Dependence of nighttime sleep duration in one-month-old infants on alterations in natural and artificial photoperiod.
Sci Rep. 2017 Mar 17;7:44749. doi: 10.1038/srep44749.
Michikawa T, Morokuma S, Nitta H, Kato K, Yamazaki S.
Comparison between air pollution concentrations measured at the nearest monitoring station to the delivery hospital and thosemeasured at stations nearest the residential postal code regions of pregnant women in Fukuoka
Environmental Health and Preventive Medicine. 2017 (in press).
【2】総説
Furue M, Uchi H, Mitoma C, Hashimoto-Hachiya A, Chiba T, Ito T, Nakahara T, Tsuji G. Antioxidants for Healthy Skin: The
Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2. Nutrients. 2017 Mar 3;9(3). pii:
E223. doi: 10.3390/nu9030223. Review. PubMed PMID: 28273792; PubMed
Central PMCID: PMC5372886.
福田俊彦、松井利郎：加齢と食品成分の血管機能改善. New Food Industry, 58(3), 23-29 (2016).
松井利郎：イワシペプチドの血圧調節作用. フードスタイル 21, 20(12), 160-165 (2016).
須藤信行．子どもの胃腸と免疫力 腸内細菌と脳腸相関．教育と医学．65 巻 2 号 166-174．2017.2．
須藤信行．脳神経系と腸内細菌叢 Microbiota 脳機能と腸内細菌叢．腸内細菌学雑誌．31 巻 1 号 23-32．2017.1．
須藤信行．腸内フローラと精神健康・精神疾患 脳－腸－腸内フローラ軸．分子精神医学．17 巻 1 号 11-18．2017.1．

10

須藤信行．腸内細菌叢と中枢神経との関連．心と社会．47 巻 4 号 52-58．2016.12．
須藤信行．腸内細菌学の新潮流－基礎医学的見地から新規治療開発まで－ 腸内細菌とストレス応答．最新医学．71 巻 9
号 1809-1814．2016.9．
須藤信行．ストレスで悪化する内科疾患－その病態と治療－《知っておきたいストレス関連疾患のメカニズム》腸内細菌と心身相関．Modern Physician．36 巻 9 号 925-928．2016.9．
須藤信行．腸内細菌の今日的話題 腸内細菌と精神健康・ストレス関連疾患．機能性食品と薬理栄養 10 巻 1 号 428-432．
2016.6．
須藤信行．脳とフローラ 腸内細菌とストレス応答・行動特性．BRAIN and NERVE: 神経研究の進歩． 68 巻 6 号 595-605．
2016. 6．
須藤信行．脳腸相関 各種メディエーター、腸内フローラから食品の機能性まで (Part 1)脳腸相関と疾患
養．128 巻 6 号 716-721．2016.5．
中島 直樹, 特集糖尿病診療における ICT 革命
月刊糖尿病, vol9, No1, 24-35, 2017.

Ⅰ-2.ICT がもたらす医療革命

うつ．臨床栄糖尿病診療の課題と ICT 活用による打破,中島 直樹, 「糖尿病情報を活用する将来の糖尿病診療」慢性疾病データ項目セット策定の流れと展望, 日本糖尿病情報学
会誌, vol15, 42-51, 2016.
Reinhold Haux, Sabine Koch, Nigel Lovell, Michael Marschollek, Naoki Nakashima, Klaus-Hendrik Wolf, Health-Enabling andAmbient Assistive Technologies: Past, Present, Future, IMIA Yearbook of Medical Informatics, 30;25(Suppl. 1), 2016.
中島 直樹, PHR 事業「電子版生活習慣病管理手帳」の実用化が示す医療への貢献, 新医療, 43(5):22-25, 2016.
中島 直樹, 情報通信技術(ICT)を活用した遠隔栄養指導の現状と今後の展開, 臨床栄養, 128(5):551-555, 2016.
田口智章.【特集 先天性横隔膜ヘルニア最新の治療と今後の課題】治療の今後の課題
小児外科. 48(5)：504-508,2016
松浦俊治、髙橋良彰、吉丸耕一朗、栁 佑典、落合正行、日高庸博、加藤聖子、田口智章.
新生児生体肝移植の治療選択～産褥期生体ドナーの是非～
日本周産期・新生児医学会雑誌. 51(5)：1451-1454,2016
高安 肇、増本幸二、田口智章、臼井則朗.
【特集 先天性横隔膜ヘルニア最新の治療と今後の課題】術後の胸郭・脊椎変形小児外科. 48(5)：504-508,2016
伊崎智子、宮田潤子、田口智章.
女性医師・男性医師がともに「豊かな人生」を送る外科医社会を目指して-理想の男女共同参画を目指して日外会誌. 117(6)：478-479,2016
伊崎智子、田口智章.
【シリーズ：こんなときどうする？（頭頸部・胸部編）】術後嚥下障害.
小児外科. 48(9):963-966.2016
田口智章、宗崎良太、木下義晶、田尻達郎.
外科治療の役割と考え方 特集 小児固形がんの最新のトピックス.
小児外科. 48(11)：1160-1168,2016
田口智章.
乳児腸重積症の外科的治療に関する知見からロタウイルスワクチン接種のリスクとベネフィットを考える.
Vaccine Digest. 12:7-8, 2016
Wakiguchi H, Ohga S:
Clinical utility of the liposteroid therapy: Potential effects on the macrophage activation.
Nihon Rinsho Meneki Gakkai Kaishi 39(3):190-96, 201611

Ohga S:
Genetic diagnosis for congenital hemolytic anemia.
Rinsho Ketsueki 57(10):1908-12, 2016
大賀正一、山城安啓、菅野 仁：
特集 貧血性疾患診療の進歩
先天性溶血性貧血の遺伝子診断
血液内科 73(2):1-6, 2016
大賀正一：広島県小児科医会会報 63 号講演録
予防接種と免疫不全 2016 (in press)
大賀正一：免疫不全と予防接種
香川県小児科医会会誌 総説, 2016 (in press)
大賀正一：先天性溶血性貧血の遺伝子診断
第 78 回日本血液学会 教育講演 臨床血液総説 2016 (in press)
高田英俊：原発性免疫不全症
最新医学 71:755-63, 2016
高田英俊：自然免疫異常 TIR 伝達経路欠損症 IRAK4 欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III:667-72, 2016
高田英俊：自然免疫異常 TIR 伝達経路欠損症 MyD88 欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III:673-76, 2016
高田英俊：メンデル遺伝型マイコバクテリア易感染疾患 (Mendelian susceptibility to mycobacterial disease) IL-12 受容体β1欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III:741-44, 2016
高田英俊：メンデル遺伝型マイコバクテリア易感染疾患 (Mendelian susceptibility to mycobacterial disease) IL-12p40 欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III:745-47, 2016
高田英俊：メンデル遺伝型マイコバクテリア易感染疾患 (Mendelian susceptibility to mycobacterial disease) IFN-γ受容体 1欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III: 748-52, 2016
高田英俊：メンデル遺伝型マイコバクテリア易感染疾患 (Mendelian susceptibility to mycobacterial disease) IFN-γ受容体 2欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III，753-56, 2016
高田英俊：メンデル遺伝型マイコバクテリア易感染疾患 (Mendelian susceptibility to mycobacterial disease) STAT1 欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III: 757-760, 2016
高田英俊：メンデル遺伝型マイコバクテリア易感染疾患 (Mendelian susceptibility to mycobacterial disease) Macrophage
gp91-phox 欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III: 761-64, 2016
高田英俊：メンデル遺伝型マイコバクテリア易感染疾患 (Mendelian susceptibility to mycobacterial disease) IGF8 欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III: 765-68, 2016
高田英俊：メンデル遺伝型マイコバクテリア易感染疾患 (Mendelian susceptibility to mycobacterial disease) ISG15 欠損症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III: 769-70, 2016
高田英俊：原発性免疫不全症の表現型をとる疾患 後天的な自己抗体産生による疾 IFN-γに対する自己抗体による成人発症免疫不全症別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III: 930-32, 201612

高田英俊：原発性免疫不全症の表現型をとる疾患 後天的な自己抗体産生による疾 IL-6 に対する自己抗体による反復性皮膚感染症
別冊日本臨床 新領域別症候群シリーズ 36 免疫症候群(第 2 版)－その他の免疫疾患を含めて－III: 933-34, 2016
高田英俊：クリオピリン関連周期性症候群
小児科診療 2016 年増刊号 79: 350, 2016
實藤雅文：小児の症候群 stiff-person 症候群
小児科診療 79:130, 2016
千手絢子、菅 礼子、諸隈誠一、實藤雅文：エコチル調査～現在と未来の子どもたちのために～第 9 回
ンターの活動チャイルドヘルス 19, 2016
落合正行：多胎児の管理と予後
産婦人科の実際 65(2) P583-87

福岡ユニットセ

双胎児の長期予後

山村健一郎：特集 慢性心疾患児の一生を診る
小児内科 48(10):1467-70, 2016

Fallot 四徴症【3】著書
Si Jing Chen, and Toshiro Matsui: Prediction of pre-diabetes and its prevention by food compounds (Chapter 1) In Natural Product
Drug Discovery; Discovery and Development of Antidiabetic Natural Products-Part 1 (Ed.) Goutam Brahmachari, Elsevier Book
Series, Elsevier (Publisher), UK (2016).
松井利郎：HPLC, GCの測定条件設定テクニックと解析事例集.
定量 技術情報協会編、東京 P.304-306, 2016.

第10章第５節

LC-MS法による低分子ペプチドの定性・

松井利郎：食べ物と健康-食品の加工（増補）、太田英明、北畠直文、白土英樹編、健康・栄養科学シリーズ
京）2016, 第９章.

南江堂（東中山二郎:ヒトマイクロバイオーム研究最前線（第1編第3節）アジア人の腸内細菌叢比較, p27-p42
N Sudo. The Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota: A Target for Dietary Intervention? Niall Hyland, Catherine
Stanton (編集). The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota. Academic Press. 293-304.
2016
Yasunobu Nohara, Sozo Inoue, Naoki Nakashima, Smart Sensors and Systems_ Health Sensor Data Analysis for a Hospital andDeveloping Countries, Springer International Publishing, 485-518, 2016.
清水 周次, 中島 直樹, 工藤 孔梨子, 安德 恭彰, 国際化プロジェクト技術担当者チーム, 遠隔医療カンファレンス
術担当者になったら読む本 入門編, 2016.

技

Shuzi Shimizu, Ho-Seong Han, Kuriko Kudo, Yoshiko Houkabe, Yasuaki Antoku, Naoki Nakashima, Telemedicine: Principles andthe Future, Jaypee Brothers Medical Publishers, 1352-1356, 2016.
Ohga S, Ishimura M:
Part 4. Platelet and Coagulation Disorders
10. Thrombotic disorders
Hematological Disorders in Children - Pathogenesis and Treatment 2016 (in press)
市村卓也、大賀正一：Ⅶ．原発性免疫不全症候群 5．免疫調節不全症(1)家族性血球貪食性リンパ組織球(FHL)症候群 ①Perforin欠損症(FHL2)
日本臨床別冊「免疫症候群(第2版) Ⅲ−その他の免疫疾患を含めて−」2016 (in press)
市村卓也、大賀正一：Ⅶ．原発性免疫不全症候群 5．免疫調節不全症(1)家族性血球貪食性リンパ組織球(FHL)症候群 ②UNC13D/Munc13-4欠損症(FHL3)
日本臨床別冊「免疫症候群(第2版) Ⅲ−その他の免疫疾患を含めて−」2016 (in press)13東 良紘、大賀正一： EBウイルス〜EBウイルス感染症が関与する免疫異常〜
日本臨床別冊「免疫症候群（第2版）Ⅱ−その他の免疫疾患を含めて−」:721-26, 2016
大賀正一: 23小児科疾患 原発性免疫不全症
今日の治療指-私はこう治療している医学書院 1432, 2016
大賀正一：エキスパートのための産婦人科・新生児領域の血液疾患診療の手引き
２．新生児血栓症
日本産婦人科新生児血液学会編集 2016 (in press)
鈴木信寛、工藤寿子、小阪嘉之、大賀正一、石黒 精、長江千愛、嶋 緑倫、瀧 正志：CVADガイドライン
日本小児血液・がん学会血栓止血委員会編集 2016 (in press)
白幡 聡、高橋幸博、茨 聡、大賀正一、河井昌彦、川口千晴、沢田 健、高橋大二郎、瀧 正志、長江千愛、西久保敏也、
水上尚典、樺山知佳：
新生児DIC診断・治療指針2015年版 日本産婦人科・新生児血液学会 2016 (in press)
大賀正一、菅野 仁：11 遺伝性球状赤血球症
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：12 口唇赤血球症
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：13 鎌状赤血球症
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：14 不安定ヘモグロビン症
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：15 サラセミア
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：16 グルコース-6-リン酸脱水素酵素欠乏症
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：17 ピルビン酸キナーゼ欠乏性貧血
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：18 11から17までに掲げるもののほか、遺伝性溶血性貧血.
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：19 溶血性貧血(脾機能亢進症によるものに限る)
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：49 先天性プロテインC欠乏症
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：50 先天性プロテインS欠乏症
小児慢性特定疾病 診断と治療社 2016 (in press)
大賀正一、菅野 仁：51 先天性アンチトロンビン欠乏症
小児慢性特定疾病 診断と治療社 2016 (in press)
長谷川俊史、大賀正一：小児の症候群, PFAPA症候群
小児科診療別冊 診断と治療社 2016 (in press)
梶本まどか、松重武志、大賀正一: 神経免疫疾患. 小児の神経免疫疾患の治療はどうすればよいか
アクチュアル 脳・神経疾患の臨床 2016 (in press)14市村卓也、大賀正一： Ⅶ．原発性免疫不全症候群 5．免疫調節不全症 (1)家族性血球貪食性リンパ組織球（FHL）症
候群③Syntaxin11欠損症（FHL4）.
日本臨床別冊「免疫症候群（第2版）Ⅲ—その他の免疫疾患を含めて−」 日本臨牀社, 2016 (in press)
市村卓也、大賀正一： Ⅶ．原発性免疫不全症候群 5．免疫調節不全症 (1)家族性血球貪食性リンパ組織球（FHL）症
候群④STXBP2/Munc18-2欠損症（FHL5）.
日本臨床別冊「免疫症候群（第2版）Ⅲ—その他の免疫疾患を含めて−」 日本臨牀社, 2016 (in press)
高田英俊：免疫不全を伴う無汗性臥位は様形成異常症
IRAK4欠損症
My88欠損症
原発性免疫不全症候群診断の手引き 診断と治療社, 2016 (in press)【4】症例報告
Iida Y, Hasegawa S, Korenaga Y, Okada S, Suzuki Y, Hirano R, Ohga S:
Infliximab therapy for a refractory Kawasaki disease associated with human parvovirus B19 infection.
J Infect Chemother 2016 (submitted)
Takada H, Ishimura M, Takimoto T, Kohagura T, Yoshikawa H, Imaizumi M, Shichijyou K, Shimabukuro Y, Kise T, Hyakuna N,
Ohara O, Nonoyama S, Hara T:
Invasive Bacterial Infection in Patients with Interleukin-1 Receptor-associated Kinase 4 Deficiency: Case Report.
Medicine (Baltimore) 95(4):e243, 2016
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui
Y:The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nat commun 2016 (in press)
Harada M, Honda Y, Hoshina T, Ohga S, Ohshima K, Kusuhara K:
Successful resolution of Epstein-Barr virus infection-associated hemophagocytic lymphohistiocytosis during the treatment course of
acute lymphoblastic leukemia.
Pediatr Neurol 2016 (in press)
Narumi H, Hasegawa S, Waki K, Fukuda K, Ohnishi Y, Ichimura T, Fujimoto Y, Katsura S, Kawano H, Ikeda E, Okada S, Ohga S:
Non-androgen secreting adrenocortical carcinoma in preadolescence: a case report and literature review.
J Pediatr Endocrinol Metab 1;29(11):1313-17, 2016
Ozono S, Nishimura M, Noguchi M, Nakagawa S, Ueda K, Inada H, Ohga S, Ito E:
Neonatal near-fatal Diamond-Blackfan anemia due to a novel mutation of ribosomal protein S19.
Pediatr Int 58(9):930-33, 2016
Wakiguchi H, Hasegawa S, Maeba S, Kimura S, Ito S, Tateishi H, Ueda K, Ohga S:
A sporadic neonatal case of epidermolysis bullosa simplex generalized intermediate with KRT5 and KRT14 gene mutations.
Am J Perinatol Rep 6:e108-e111, 2016
Yanagi T, Mizuochi T, Takaki Y, Eda K, Mitsuyama K, Ishimura M, Takada H, Shouval DS, Griffith AE, Snapper SB, Yamashita Y,
Yamamoto K:
Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: acase report.
BMC Gastroenterol 28;16:10, 2016
Koga Y, Oba U, Kato W, Ono H, Nakashima K, Takada H:
Sudden Death during Palliative Radiotherapy for a Relapsed Osteosarcoma.
J Palliat Med 19(10):1028-29, 2016
Koga Y, Oba U, Kato W, Ono H, Nakashima K, Takada H:
A paediatric case of successful non-myeloablative bone marrow transplantation after azacitidine therapy for non-Down syndrome
acute megakaryoblastic leukaemia with monosomy 7.

15

Pediatr Transplant 20(6):868-70, 2016
Tocan V, Koga Y, Ono H, Nakashima K, Terashi E, Morihana E, Yamamura K, Sakamoto T, Takada H:
Is Metastatic Rhabdomyosarcoma an Indication for Cardioverter Defibrillator Implantation?
Pediatr Blood Cancer 63(8):1501-2, 2016
Nanishi E, Hoshina T, Nishio H, Aman M, Sakamoto A, Ohga S, Hara T:
Intramuscular venous malformation in an infant masquerading as a recurrent gonarthritis.
Pediatr Neonatol 2016 (in press)
Kanemasa H, Sakai Y, Fukai R, Torio M, Miyake N, Ono H, Akamine S, Nishiyama K, Sanefuji M, Ishizaki Y, Torisu H, Saitsu H,
Matsumoto N, Hara T, Ohga S:
De novo p.Arg756Cys mutation of ATP1A3 causes an atypical form of alternating hemiplegia of childhood with prolonged paralysis
and choreoathetosis.
BMC Neurology 16:174, 2016
Ichiyama M, Ohga S, Ochiai M, Fukushima K, Ishimura M, Torio M, Urata M, Hotta T, Kang D, Hara T:
Fetal hydrocephalus and neonatal stroke as the first presentation of protein C deficiency.
Brain Dev 38(2):253-6, 2016
Nagata H, Yamamura K, Nagata K, Uike K, Morihana E, Ihara K, Yumoto Y, Fusazaki N, Kado H, Kato K, Taguchi T, Hara T:
Management of congenital diaphragmatic hernia with transposition of the great arteries.
Pediatr Int 58(6):516-18, 2016
Nishiyama K, Imai T, Ohkubo K, Sanefuji M, Takada H:
Resolution of hydronephrosis in a patient with mucopolysaccharidosis type II with enzyme replacement therapy.
Urology 2016 (accepted)
Matsuoka W, Kaku N, Hirata Y, Lee S, Akahoshi T, Sugimori H, Hayashida M, Souzaki R, Fujita N, Asayama Y, Taguchi T,
Takada H, Maehara Y:
Emergent transcatheter arterial embolization for norovirus-associated life-threatening ulcer bleeding to achieve successful hemostasis
in 2-year-old boy.
Acute Med Surg 3:415-18, 2016
兼安秀信、脇口宏之、木畑鉄弘、岡崎史子、長谷川俊史、大賀正一：
4種3剤の生ワクチンを初回同時接種した関節型若年性特発性関節炎の2例
小児感染免疫 2016 (in press)
平田悠一郎、李 守永、賀来典之、山村健一郎、馬場晴久、漢那朝雄、杉 森宏、原 寿郎：保育所、中学校で発生した小児心肺停止
日本小児科学会雑誌 120(7):1099-104, 201616