令和２年度 業績【１】原 著
Todani T,Hata T, Miyata N,et al. Dietary delivery of acetate to the colon using acylated starches as a carrier exerts anxiolytic
effects in mice. Physiology & Behavior;223:113004 :2020 Sep

Miyata N,Hata T, Takakura S,et al. Metabolomics profile of Japanese female patients with restricting-type anorexia nervosa.
Physiology & Behavior;228:113204 :2021 Jan

Shimizu M, Kawai K,Yamashita M,et al. Very long chain fatty acids are an important marker of nutritional status in patientswith anorexia nervosa: a case control study. Biopsychosoc Med;14:14:2020 Jul

Tatsushima K, Hasuzawa N, Lixiang W,et al. Vesicular ATP release from hepatocytes plays a role in the progression of
nonalcoholic steatohepatitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;1867(3):166013:2021
Mar

滝吉美知香、田中真理, 典型発達者における自閉スペクトラム症理解と自己肯定意識との関連, 発達心理学研
究, 32, 1, 24-36, 2021.03.

Mari TANAKA Understanding forced smiles in individuals with autism spectrum disorder, Bulletin of Center for ClinicalPsychology and Human Development, 12, 35-40, 2021.03.

Aikana Ohno ,Mari Tanaka, The effect of kawaii on task performance:Viewing cute images without baby schema, Kyushu
University psychological Research, 21, 15-22, 2020.04.

Mari TANAKA, Akiko TAKAHARA, Psychosocial effects of the Great East Japan Earthquake on Persons with
Disabilities., The Journal of Rehabilitation Psychology, 46, 1, 25-37, 2021.01.

Kana Maehara, Seiichi Morokuma, Kazushige Nakahara, Hikohiro Okawa, Kiyoko Kato; A Study on the Association
Between Eye Movements and Regular Mouthing Movements (RMMs) in Normal Fetuses Between 24 to 39 Weeks of
Gestation. PLoS One. May 29;15(5):e0233909. 2020

Nakahara K, Michikawa T, Morokuma S, Ogawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Shimono M, Kawamoto T,
Ohga S, Kusuhara K; Japan Environment and Children’s Study Group.; Non-reassuring foetal status and sleep problems in
1-year-old infants in the Japan Environment and Children's Study: a cohort study.
Sci Rep. Jul 10;10(1):11432. 2020

Nakahara K, Michikawa T, Morokuma S, Ogawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Shimono M, Kawamoto T,
Ohga S, Kusuhara K; Japan Environment and Children’s Study Group.; Association of maternal sleep before and duringpregnancy with preterm birth and early infant sleep and temperament.
Sci Rep. Jul 6;10(1):11084. 2020

Michikawa T, Morokuma S, Yamazaki S, Takami A, Sugata S, Yoshino A, Takeda Y, Nakahara K,
Saito S, Hoshi J, Kato K, Nitta H, Nishiwaki Y.
Exposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications inTokyo: a register-based study
Journal of Exposure Science & Environmental Epidemiology (J Expo Sci Environ Epidemiol). Feb 18. 2021

Kikuchi K, Yi S, Yasuoka J, Tuot S, Okawa S, Murayama M, Yem S, Chhuon P, Eng S, Huot C, Morokuma S
Oral health among HIV-positive and HIV-negative children in Phnom Penh, Cambodia: a cross-sectional study
BMJ Paediatrics Open. 11 March, 2021

Murata T, Kyozuka H, Fukuda T, Yasuda S, Yamaguchi A, Morokuma S, Sato A, Ogata Y, Shinoki K, Hosoya M, Yasumura
S, Hashimoto K, Nishigori H, Fujimori K; Japan Environment and Children’s Study (JECS) Group.
Maternal sleep duration and neonatal birth weight: The Japan Environment and Children’s StudyBMC Pregnancy and Childbirth. Apr 12;21(1):295. 2021

Nakahara K, Michikawa T, Morokuma S, Ogawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Shimono M, Kawamoto T,
Ohga S, Kusuhara K; Japan Environment and Children’s Study Group.
Influence of physical activity before and during pregnancy on infant's sleep and neurodevelopment at 1-year-old.
Sci Rep. Apr 14;11(1):8099. 2021

Therdtatha, P., Song, Y., Tanaka, M., Mariyatun, M., Almunifah, M., Manurung, N. E. P., Indriarsih, S., Lu, Y., Nagata, K.,
Fukami, K., Ikeda, T., Lee, Y.-K., Rahayu, E. S., Nakayama, J. Gut Microbiome of Indonesian Adults Associated with
Obesity and Type 2 Diabetes: A Cross-Sectional Study in an Asian City, Yogyakarta.

Microorganisms 9(5), 897, 2021..

Kamil, R. Z., Murdiati, A., Juffrie, M., Nakayama, J., Rahayu, E. S. Gut microbiota and short-chain fatty aci profile between
normal and modelrate malnutrition children in Yogyakarta, Indonesia. Microorganisms 9(1), 1-15, 2021.

Chumponsuk, T., Gruneck, L., Gentekaki, E., Jitprasertwong, P., Kullawong, N., Nakayama, J., Popluechai, S. The salivary
microbiota of Thai adults with metabolic disorders and association with diet. Archives of Oral Biology, 122, 105036, 2021.

Ikeda, T., Aida, M., Yoshida, Y., Matsumoto, S., Tanaka, M., Nakayama, J., Nagao, Y., Nakata, R., Oki, E., Akahoshi, T.,
Okano, S., Nomura, M., Hashizume, M., Maehara, Y. Alteration in fecal bile acids, gut microbial composition and diversity
after laparoscopic sleeve gastrectomy. British Journal of Surgery, 107(12) 1673-1685. 2020.

Tanaka, M., Onizuka, S., Mishima, R., Nakayama, J*. Cultural isolation of spore-forming bacteria in human feces usingbile acids. Scientific reports 10(1), 15041, 2020.

Furukawa, M., Moriya, K., Nakayama, J., Inoue, T., Momoda, R., Kawaratani, H., Namisaki, T., Sato, S., Douhara, A.,
Kaji, K., Kitade, M., Shimozato, N., Sawada, Y., Saikawa, S., Takaya, H., Kitagawa, K., Akahane, T., Mitoro, A., Yamao,J., Tanaka, Y. & Yoshiji, H. Gut dysbiosis associated with clinical prognosis of patients with primar biliary cholangitis.
Hepathology Research, 50(7), 840-852, 2020.

Khine, W. W. T., Rahayu, E. S., See, T. Y., Kuah, S., Salminen, S., Nakayama, J., Lee, Y. K., Indonesian children fecal
microbiome from birth until weaning was different from microbiomes of their mothers. Gut Microbes. 12(1), 1761240,
2020.

Fujiwara, M., Kuwahara, D., Hayashi, M., Zendo, T., Sato, M., Nakayama, J.*, Sonomoto, K. Lowering effect of variable
Pediococcus pentosaceu QU19 on the rise in postprandial glucose. Bioscience of Microbiota, Food and Health 39(2), 5764, (2020).

Tanaka, M., Sanefuji, M., Morokuma, S., Yoden, M., Momoda, R., Sonomoto, K., Ogawa, M., Kato, K., Nakayama, J*.
The association between gut microbiota development and maturation of intestinal bile acid metabolism in the first 3 y ofhealthy Japanese infants. Gut Microbes 11(2), 205-216, 2020.

Furue M, Ishii Y, Tsukimori K, Tsuji G.
Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from
Yusho.
Int J Mol Sci. 22(2):708,2021.

Shibata M, Ohara T, Hosoi M, Jun H, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E,
Anno K, Sudo N, Ninomiya T.. Emotional loneliness is associated with a risk of dementia in a general Japanese older
population: the Hisayama Study. J Gerontol B Psychol Sci Soc Sci. 2020 (in press)

Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ohara T, Hata J, Kokubo
Y, Uchida K, Taki Y, Kumagai S, Yonemoto K, Yoshida H, Muto K, Momozawa Y, Akiyama M, Kubo M, Ikeda M, Kanba
S, Kiyohara Y; JPSFC-AD Study Group.. Study design and baseline characteristics of a population-based prospective
cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD).
Environ Health Prev Med. 25(1):64,2020

Sasaki T, Tsuboi N, Marumoto H, Okabayashi Y, Haruhara K, Kanzaki G, Koike K, Ogura M, Ninomiya T, Yokoo T..
Nephron Number and Time to Remission in Steroid-Sensitive Minimal Change Disease. Kidney Med. 2(5):559568.e1,2020

Ishida Y, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Furuta Y, Oishi E, Hata J, Kitazono T, Ninomiya T..
Influence of the Accumulation of Unhealthy Eating Habits on Obesity in a General Japanese Population: The Hisayama
Study. Nutrients. 12(10):3160,2020

Mihara A, Ohara T, Hata J, Honda T, Chen S, Sakata S, Oishi E, Hirakawa Y, Nakao T, Kitazono T, Ninomiya T..
Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: The Hisayama
Study. Atherosclerosis. 311:52-59,2020

Sasaki M, Miyake M, Fujiwara K, Nanba H, Akiyama M, Yanagi Y, Harada S, Tabara Y, Yasuda M, Yamashita H, Kayama
T, Tsubota K, Matsuda F, Hashimoto S, Ueda E, Ninomiya T, Takebayashi T, Tsujikawa A, Sonoda KH, Kawasaki R..
Cohort Profile: The Ganka-Ekigaku Network (GEN), a Network of Japanese Ophthalmological Epidemiology Studies.
Ophthalmic Epidemiol. 28(3):237-243,2021

McGrath ER, Himali JJ, Levy D, Conner SC, DeCarli C, Pase MP, Ninomiya T, Ohara T, Courchesne P, Satizabal CL,
Vasan RS, Beiser AS, Seshadri S.. Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of VascularBrain Injury and Dementia. J Am Heart Assoc. 9(19):e014659,2020

Asayama K, Tabara Y, Oishi E, Sakata S, Hisamatsu T, Godai K, Kabayama M, Tatsumi Y, Hata J, Kikuya M, Kamide K,
Miura K, Ninomiya T, Ohkubo T.. Recent status of self-measured home blood pressure in the Japanese general population:a modern database on self-measured home blood pressure (MDAS). Hypertens Res. 43(12):1403-1412,2020

Kimura Y, Yoshida D, Hirakawa Y, Hata J, Honda T, Shibata M, Sakata S, Uchida K, Kitazono T, Ninomiya T.. Dietaryfiber intake and risk of type 2 diabetes in a general Japanese population: The Hisayama Study. J Diabetes Investig.
12(4):527-536,2021

Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M.. Parenting
style during childhood is associated with the development of chronic pain and a patient's need for psychosomatic treatment
in adulthood: A case-control study. Medicine (Baltimore). 99(29):e21230,2020

Hirakawa Y, Hata J, Yoshinari M, Higashioka M, Yoshida D, Shibata M, Honda T, Sakata S, Kato H, Teramoto
T, Maki H, Nishimoto S, Kitazono T, Ninomiya T.. 30-minute postload plasma glucose levels during an oral glucose
tolerance test predict the risk of future type 2 diabetes: the Hisayama Study. BMJ Open Diabetes Res Care.
8(1):e001156,2020

Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Furuta Y, Oishi E, Sakata S, Kanba S, Kitazono T, Ninomiya
T.. Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan. Neurology.
95(5):e508-e518,2020

Imai Y, Hirata T, Saitoh S, Ninomiya T, Miyamoto Y, Ohnishi H, Murakami Y, Iso H, Tanaka S, Miura K, Tamakoshi A,
Yamada M, Kiyama M, Ueshima H, Ishikawa S, Okamura T; Evidence for Cardiovascular Prevention from Observational
Cohorts in Japan (EPOCH-JAPAN) Research Group.. Impact of hypertension stratified by diabetes on the lifetime risk ofcardiovascular disease mortality in Japan: a pooled analysis of data from the Evidence for Cardiovascular Prevention from
Observational Cohorts in Japan study. Hypertens Res. 43(12):1437-1444,2020

Shikata K, Haneda M, Ninomiya T, Koya D, Suzuki Y, Suzuki D, Ishida H, Akai H, Tomino Y, Uzu T, Nishimura M, Maeda
S, Ogawa D, Miyamoto S, Makino H; Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETTJapan) collaborative group.. Randomized trial of an intensified, multifactorial intervention in patients with advanced-stage
diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan). J Diabetes
Investig. 12(2):207-216,2021

Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T,
Tsutsui H, Ninomiya T.. Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial
fibrillation in a general population: the Hisayama Study. Int J Cardiol. 320:90-96,2020

Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH.. Five-Year
Incidence of Myopic Maculopathy in a General Japanese Population: The Hisayama Study. JAMA Ophthalmol.
138(8):887-893,2020

Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima
Y, Ninomiya T.. Prevalence and Mortality of Sarcopenia in a Community-dwelling Older Japanese Population: The
Hisayama Study. J Epidemiol. 31(5):320-327,2021

Tomiyama H, Vlachopoulos C, Xaplanteris P, Nakano H, Shiina K, Ishizu T, Kohro T, Higashi Y, Takase B, Suzuki T,
Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Tanaka A, Maemura
K, Ohya Y, Furukawa T, Ito H, Ohkuma T, Ninomiya T, Chikamori T, Yamashina A, Ueda SI.. Usefulness of the SAGE
score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension. Hypertens
Res. 43(11):1284-1292,2020

Higashioka M, Sakata S, Honda T, Hata J, Shibata M, Yoshida D, Goto K, Kitazono T, Osawa H, Ninomiya T.. The
Association of Small Dense Low-Density Lipoprotein Cholesterol and Coronary Heart Disease in Subjects at High
Cardiovascular Risk. J Atheroscler Thromb. 28(1):79-89,2021

Yamasaki K, Hata J, Furuta Y, Hirabayashi N, Ohara T, Yoshida D, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T..
Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic ResonanceImaging in Elderly Japanese - The Hisayama Study. Circ J. 84(6):935-942,2020

Chen S, Honda T, Ohara T, Hata J, Hirakawa Y, Yoshida D, Shibata M, Sakata S, Oishi E, Furuta Y, Kitazono T, Ninomiya
T.. Serum homocysteine and risk of dementia in Japan. J Neurol Neurosurg Psychiatry. 91(5):540-546,2020

Oku S, Takeshita T, Futatsuki T, Kageyama S, Asakawa M, Mori Y, Miyamoto T, Hata J, Ninomiya T, Kashiwazaki H,
Yamashita Y.. Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic
stem cell transplantation. PLoS Pathog. 16(3):e1008348,2020

Inaishi J, Saisho Y, Hirakawa Y, Yoshida D, Hata J, Mukai N, Watanabe Y, Oda Y, Itoh H, Ninomiya T.. Association of
glucose tolerance status with pancreatic β- and α-cell mass in community-based autopsy samples of Japanese individuals:
The Hisayama Study. J Diabetes Investig. 11(5):1197-1206,2020

Hachiya T, Hata J, Hirakawa Y, Yoshida D, Furuta Y, Kitazono T, Shimizu A, Ninomiya T.. Genome-Wide Polygenic Score
and the Risk of Ischemic Stroke in a Prospective Cohort: The Hisayama Study. Stroke. 51(3):759-765,2020

Ohara T, Furuta Y, Hirabayashi N, Hata J, Hirakawa Y, Honda T, Yoshida D, Shibata M, Kitazono T, Ninomiya T.. Elevatedserum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a
general elderly population of Japanese: The Hisayama Study. J Diabetes Investig. 11(4):971-979,2020

Sakata S, Hata J, Honda T, Hirakawa Y, Oishi E, Shibata M, Yoshida D, Goto K, Kitazono T, Ninomiya T.. Serum uric acidlevels and cardiovascular mortality in a general Japanese population: the Hisayama Study. Hypertens Res. 43(6):560568,2020

Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues JF, DavisPlourde K, Debette S, Di Angelantonio E, Feart C, Frikke-Schmidt R, Gregson J, Haan MN, Hassing LB, Hayden KM,
Hoevenaar-Blom MP, Kaprio J, Kivimaki M, Lappas G, Larson EB, LeBlanc ES, Lee A, Lui LY, Moll van Charante EP,
Ninomiya T, Nordestgaard LT, Ohara T, Ohkuma T, Palviainen T, Peres K, Peters R, Qizilbash N, Richard E, Rosengren A,
Seshadri S, Shipley M, Singh-Manoux A, Strand BH, van Gool WA, Vuoksimaa E, Yaffe K, Huxley RR.. Association ofanthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million
adults with 57 294 cases of dementia. Obes Rev. 21(4):e12989,2020

Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya
T.. Small Dense Low-Density Lipoprotein Cholesterol and the Risk of Coronary Heart Disease in a Japanese Community.
J Atheroscler Thromb. 27(7):669-682,2020

Higashioka M, Hirakawa Y, Kawamura R, Honda T, Hata J, Yoshida D, Takata Y, Kitazono T, Osawa H, Ninomiya T..
Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely
associated with serum resistin levels: The Hisayama Study. J Diabetes Investig. 11(2):482-489,2020

Yang Y, Hozawa A, Kogure M, Narita A, Hirata T, Nakamura T, Tsuchiya N, Nakaya N, Ninomiya T, Okuda N,
Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K.. Dietary Inflammatory Index Positively AssociatedWith High-Sensitivity C-Reactive Protein Level in Japanese From NIPPON DATA2010. J Epidemiol. 30(2):98-107,2020

Hatabe Y, Shibata M, Ohara T, Oishi E, Yoshida D, Honda T, Hata J, Kanba S, Kitazono T, Ninomiya T.. Decline in
Handgrip Strength From Midlife to Late-Life is Associated With Dementia in a Japanese Community: The Hisayama Study.
J Epidemiol. 30(1):15-23,2020

田中一成、山本咲暁子、大曲勝久、湯浅正洋、土橋 葵、宮田裕次、吉野 豊、小野博之、松井利郎、山村春男：
未熟ミカンと緑茶葉を混合揉捻して製造した発酵茶葉由来ヘスペリジン摂取が血圧に及ぼす影響〜ランダム化二重盲検プラセボ対象並行群間比較試験. 薬理と治療（Jpn. Pharmacol. Ther.）, 48(2), 225-235 (2020).

Takashi Ichinose, Hiroyasu Murasawa, Tomoko Ishijima, Shinji Okada, Keiko Abe, Saki Matsumoto, Toshiro Matsui,
Shigeki Furuya: Tyr-Trp administration facilitates brain norepinephrine metabolism and ameliorates a short-term memory
deficit

in

a

mouse

model

of

Alzheimer’s

disease.

PLoS

ONE,

15(5),

e0232233(2020).

https://doi.org/10.1371/journal.pone.0232233

Mitsuru Tanaka, Hayato Kiyohara, Atsuko Yoshino, Akihiro Nakano, Fuyuko Takata, Shinya Dohgu, Yasufumi Kataoka,
and Toshiro Matsui: Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory
impairment in mice. npj Science of Food, 4, 7–10 (2020). https://doi.org/10.1038/s41538-020-0067-3

Akira Tsujita, Asami Nagasaka, Hidehiko Okazaki, Shin Ogawa, Akinaga Gohda, and Toshiro Matsui: Quantitative
determination of H2 in human blood by 22Ne-aided gas chromatography-mass spectrometry using a single quadrupole
instrument. Anal. Sci., 36(10), 1231–1236 (2020).

Juneha Bak, Yoshiyuki Miyazaki, Hayato Nakano, and Toshiro Matsui: Ligand-aided 1H nuclear magnetic resonancespectroscopy for non-destructive estimation of sulfate content in sulfated saccharides. Anal. Sci., 36(10), 1269–1274 (2020).

Mitsuru Tanaka, Chung Hsuan, Masataka Oeki, Weilin Shen, Asuka Goda, Yusuke Tahara, Takeshi Onodera, Keisuke
Sanematsu, Tomotsugu Rikitake, Eiji Oki, Yuzo Ninomiya, Rintaro Kurebayashi, Hideto Sonoda, Yoshihiko Maehara,
Kiyoshi Toko, and Toshiro Matsui: Identification of characteristic compounds of moderate volatility in breast cancer celllines. PLoS ONE, 15(6), e0235442 (2020). https://doi.org/10.1371/journal. pone.0235442

Ye Zhang, Kazuhiro Takao, Chizuru Abe, Kuni Sasaki, Koji Ochiai, and Toshiro Matsui: Intestinal absorption of prenylated
isoflavones, glyceollins, in Sprague-Dawley rats. J. Agric. Food Chem., 68(31), 8205–8211 (2020).

Guanzhen Gao, Chizumi Abe, Alexia M. Nectoux, Shu-Wei Huang, Yuji Miyata, Kazunari Tanaka, Takashi Tanaka, Haruo
Yamamura, and Toshiro Matsui: Anti-hypertensive effect of hesperidin and hesperidin-containing fermented Mikan tea inspontaneously hypertensive rats. Food Sci. Technol. Res., 26(6), 779–787 (2020).

Baorui Li, Lei Fu, Chizumi Abe, Alexia M. Nectoux, Ayaka Yamamoto, and Toshiro Matsui: Theaflavins inhibit glucose
transport across Caco-2 cells through the downregulation of the Ca2+/AMP-activated protein kinase-mediated glucose
transporter SGLT1. J. Funct. Foods, 75, 104273 (2020).

Hiroyuki Kubota, Koji Sakamoto, and Toshiro Matsui: A confocal Raman microscopic visualization of small penetrants incellulose acetate using a deuterium-labeling technique. Sci. Rep., 10, 16426 (2020).

Kawamoto T, Miyake Y, Tanaka K, Nagano J, Sasaki S, Hirota Y: Maternal
prenatal stress and infantile wheeze and asthma: the Osaka Maternal andChild Health Study. J Psychosom Res, 135, 110143, 2020

Sun M, Nakashima T, Yoshimura Y, Honden A, Nakagawa T, Saijo H, Watanabe
Y, Ajimi T, Yasunari S, Yamada Y, Nagano J, Okamoto T, Ishikawa H,
Ohnuki K, Fujimoto N, Shimizu K: Effects and interaction of different
interior material treatment and personal preference on psychological andphysiological responses in living environment. J Wood Sci 66(1), 2020

Yokota S, Tanaka M (2020) The cognitive function of deception in children with autism spectrum disorder, Journal ofSpecial Education Research, 9(1), 1-9.

横田晋務・松崎 泰・田中真理 (2020) 大学教員および学生における自閉スペクトラム症学生への支援に対する意識－身体障害学生への支援に対する意識との関連から－, 特殊教育学研究, 57,(4,5), 233-245.

Kobayashi A, Yokota S, Takeuchi H, Asano K, Asano M, Sassa Y, Taki Y, Kawashima R (2020) Increased grey mattervolume of the right superior temporal gyrus in healthy children with autistic cognitive style: A VBM study, Brain andCognition, 139, doi: 10.1016/j.bandc.2019.105514

Hashimoto T, Higuchi H, Uno A, Yokota S, Asano K, Taki Y, Kawashima R (2020) Association between resting-statefunctional connectivity and reading in two writing systems in Japanese children with and without developmental dyslexia,
Brain Connectivity, 10, 245-266.

Suzuki T, Uruno A, Yumoto A, Taguchi K, Suzuki M, Harada N, Ryoke R, Naganuma E, Osanai N, Goto A, Suda H,
Browne R, Otsuki A, Katsuoka F, Zorzi M, Yamazaki T, Saigusa D, Koshiba S, Nakamura T, Fukumoto S, Ikehata H,
Nishikawa K, Suzuki N, Hirano I, Shimizu R, Oishi T, Motohashi H, Tsubouchi H, Okada R, Kudo T, Shimomura M,
Kensler TW, Mizuno H, Shirakawa M, Takahashi S, Shiba D, Yamamoto M.

Nrf2 contributes to the weight gain of mice during space travel.
Commun Biol.

8;3(1):496. 2020.

Chiba Y, Saito K, Martin D, Boger ET, Rhodes C, Yoshizaki K, Nakamura T, Yamada A, Morell RJ, Yamada Y, Fukumoto
S.
Single-Cell RNA-Sequencing From Mouse Incisor Reveals Dental Epithelial Cell-Type Specific Genes.
Front Cell Dev Biol. 8:841. 2020.

Sato-Suzuki Y, Washio J, Wicaksono DP, Sato T, Fukumoto S, Takahashi N.
Nitrite-producing oral microbiome in adults and children.
Sci Rep. 10(1):16652.

2020.

Hoshikawa S, Shimizu K, Watahiki A, Chiba M, Saito K, Wei W, Fukumoto S, Inuzuka H.
Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation.
FASEB J. 34(11):14930-14945. 2020.

Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H.
Lipin-2 degradation elicits a proinflammatory gene signature in macrophages.
Biochem Biophys Res Commun. 524(2):477-483. 2020.

Saito K, Michon F, Yamada A, Inuzuka H, Yamaguchi S, Fukumoto E, Yoshizaki K, Nakamura T, Arakaki M, Chiba Y,
Ishikawa M, Okano H, Thesleff I, Fukumoto S.
Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ.
iScience. 23(7):101329. 2020.

Chiba Y, Yoshizaki K, Saito K, Ikeuchi T, Iwamoto T, Rhodes C, Nakamura T, de Vega S, Morell RJ, Boger ET, Martin D,
Hino R, Inuzuka H, Bleck CKE, Yamada A, Yamada Y, Fukumoto S.
G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts.
J Biol Chem. 295(45):15328-15341. 2020.

Wang X, Chiba Y, Jia L, Yoshizaki K, Saito K, Yamada A, Qin M, Fukumoto S.
Expression Patterns of Claudin Family Members During Tooth Development and the Role of Claudin-10 (Cldn10) in
Cytodifferentiation of Stratum Intermedium.
Front Cell Dev Biol. 8:595593. 2020.

Sun X, Kato H, Sato H, Torio M, Han X, Zhang Y, Hirofuji Y, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K.
Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic
neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia.

Biochem Biophys Rep. 26:100968. 2021.

Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H.
Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages.
Int J Mol Sci. 22(6):2893. 2021.

Yuniartha R, Yamaza T, Sonoda S, Yoshimaru K, Matsuura T, Yamaza H, Oda Y, Ohga S, Taguchi T. Cholangiogenic
potential of human deciduous pulp stem cell-converted hepatocyte-like cells. Stem Cell Res Ther. 12(1):57. 2021

Sonoda S, Murata S, Nishida K, Kato H, Uehara N, Kyumoto YN, Yamaza H, Takahashi I, Kukita T, Yamaza T.
Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis
mouse model. Stem Cell Res Ther.

11(1):296. 2020

Nakamura T, Iwamoto T, Nakamura HM, Shindo Y, Saito K, Yamada A, Yamada Y, Fukumoto S, Nakamura T. Regulationof miR-1-Mediated Connexin 43 Expression and Cell Proliferation in Dental Epithelial Cells. Front Cell Dev Biol. 8:156.
2020.

Funada K, Yoshizaki K, MIyazaki K, Han X, Yuta T, Tian T, Mizuta K, Fu Y, Iwamoto T, Yamada A, Takahashi I, Fukumoto
S. microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during toothdevelopment. Sci Rep. 10(1):4918. 2020

Takaki N, Uchiwa T, Furuse M, Yasuo S. Effect of postnatal photoperiod on DNA methylation dynamics in the mousebrain. Brain Res 1733: 146725. (2020)

Fumihiko Kinoshita, Takanori Yamashita, Yuka Oku, Keisuke Kosai, Yuki Ono, Sho Wakasu, Naoki Haratake, Gouji
Toyokawa, Tomoyoshi Takenaka, Tetsuzo Tagawa, Mototsugu Shimokawa, Naoki Nakashima, Masaki Mori, Prognostic
Impact of Albumin-bilirubin (ALBI) Grade on Non-small Lung Cell Carcinoma: A Propensity-score Matched Analysis,
Anticancer Research, 41(3):1621-1628, 2021.03.

Tasuku Okui, Chinatsu Nojiri, Shinichiro Kimura, Kentaro Abe, Sayaka Maeno, Masae Minami, Yasutaka Maeda, Naoko
Tajima, Tomoyuki Kawamura, Naoki Nakashima, Performance evaluation of case defnitionsof type 1 diabetes for healthinsurance claimsdata in Japan, BMC Medical Informatics and Decision Making, doi:10.1186/s12911-021-01422-z,
2021.02.

錦谷 まりこ, 奥井 佑, 野原 康伸, 清祐 麻紀子, 山下 貴範, 高田 敦史, 康 東天, 百瀬 敦, 中山 慶一, 德永章二, 中島 直樹, 病院情報システムを用いた腸管外病原性大腸菌による侵襲性感染症罹患率の推定, 第 5 回日
本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会 抄録集, 26, 2020.12.

山下 貴範, 中井 真也, 木下 喬, 若田 好史, 野原 康伸, 中島 直樹, 鴨打 正浩, AMED ePath 事業のデータを用いた 2 型糖尿病患者における患者アウトカム解析, 第 5 回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会 抄録集, 23, 2020.12.

平田 明恵, 石兼 真, 奥井 佑, 野尻 千夏, 高橋 富美, 中島 直樹, 電子カルテデータを用いたレニン・アンギ
オテンシン系抑制薬に関連する悪性腫瘍予後の検討, 第 5 回日本糖尿病・生活習慣病ヒューマンデータ学会年
次学術集会

抄録集, 19, 2020.12.

Rieko Izukura, Takeshi Nakahara, Takamichi Ito, Chinatsu Nojiri, Tadashi Kandabashi, Takanori Yamashita, Atsushi
Takada, Yoshiaki Uyama, Naoki Nakashima, An Electronic Phenotyping Algorithm to Identify Cases of Stevens-Johnson
Syndrome/Toxic Epidermal Necrolysis in the MID-NET Database, Asia-Pacific Association for Medical Informatics(APAMI2020) Proceedings, 208-209, 2020.11.

Mariko Nishikitani, Yasunobu Nohara, Rafiqul Islam Maruf, Fumihiko Yokota, Kimiyo Kikuchi, Ashir Ahmed, Nazneen
Sultana, Naoki Nakashima, Effects of Renal Dysfunction on the Improvement of Anemia in Bangladesh: An
Epidemiological Analysis of Health Checkup Data with ICT Intervention, Asia-Pacific Association for Medical Informatics(APAMI2020) Proceedings, 144-148, 2020.11.

Fumihiko Yokota, Ashir Ahmed, Mariko Nishikitani, Rafiqul Islam Maruf, Rieko Izukura, Rajib Chowdhury, Kimiyo
Kikuchi, Yoko Sato, Yasunobu Nohara, Naoki Nakashima, Comparisons of Anthropometric Indices for Predicting Type 2
Diabetes Among Participants in Telemedicine and Health Checkups in Bangladesh, Asia-Pacific Association for Medical
Informatics (APAMI2020) Proceedings, 138-143, 2020.11.

Takanori Yamashita, Yoshifumi Wakata, Hideki Nakaguma, Yasunobu Nohara, Shinji Hato, Susumu Kawamura, Shuko
Muraoka, Masatoshi Sugita, Mihoko Okada, Naoki Nakashima, Hidehisa Soejima, Machine Learning for Classification of
Postoperative Patient Status Using Standardized Medical Data, Asia-Pacific Association for Medical Informatics(APAMI2020) Proceedings, 131, 2020.11.

Nicholas Pang, Helen Benedict Lasimbang, Mohd Hanafi Ahmad Hijazi, Mohd Nizar Bin Hamild, Mohd Azhar Bin Dris,
Wendy Shoesmith, Fumihiko Yokota, Rafiqul Islam Maruf, Naoki Nakashima, OHIDAS Toolkit, the PHC, and Tanya
Pakar: A Multi-level, Vertically Integrated Digital Health Promotion, Primary Prevention and Telemedicine Provision
Programme, Asia-Pacific Association for Medical Informatics (APAMI2020) Proceedings, 120-124, 2020.11.

Shaira Tabassum, Masuda Begum Sampa, Rafiqul Islam Maruf, Fumihiko Yokota, Naoki Nakashima, Ashir Ahmed, An
Analysis on Remote Healthcare Data for Future Health Risk Prediction to Reduce Health Management Cost, Asia-Pacific
Association for Medical Informatics (APAMI2020) Proceedings, 115-119, 2020.11.

Rafiqul Islam Maruf, Mahmudur Rahman, Nazneen Sultana, Fumihiko Yokota, Kimiyo Kikuchi, Yoko Sato, Rieko Izukura,

Mariko Nishikitani, Ashir Ahmed, Naoki Nakashima, COVID-19 System in Portable Health Clinic for Patient Follow-up
Ensuring Clinical Safety of Both Patients and Health Workers, Asia-Pacific Association for Medical Informatics(APAMI2020) Proceedings, 98, 2020.11.

Yasunobu Nohara, Koutarou Matsumoto, Hidehisa Soejima, Naoki Nakashima, Explanation of Machine Learning Models
Using Shapley Additive Explanation and Application for Real Data in Hospital, Asia-Pacific Association for Medical
Informatics (APAMI2020) Proceedings, 95, 2020.11.

Kimiyo Kikuchi, Yoko Sato, Rieko Izukura, Mariko Nishikitani, Rafiqul Maruf Islam, Kiyoko Kato, Seiichi Morokuma,
Meherun Nessa, Yasunobu Nohara, Fumihiko Yokota, Ashir Ahmed, Naoki Nakashima, Portable Health Clinic for
Sustainable Care of Mothers and Newborns in Rural Bangladesh, Asia-Pacific Association for Medical Informatics(APAMI2020) Proceedings, 49-55, 2020.11.

Hidehisa Soejima, Koutarou Matsumoto, Naoki Nakashima, Yasunobu Nohara, Takanori Yamashita, Jiro Machida, Hideki
Nakaguma, A functional learning health system in Japan: Experience with processes and information infrastructure toward
continuous health improvement, Learning Health Systems, doi:10.1002/lrh2.10252, 2020.11.

Tadashi Sofue, Naoki Nakagawa, Eiichiro Kanda, Hajime Nagasu, Kunihiro Matsushita, Masaomi Nangaku, Shoichi
Maruyama, Takashi Wada, Yoshio Terada, Kunihiro Yamagata, Ichiei Narita, Motoko Yanagita, Hitoshi Sugiyama, Takashi
Shigematsu, Takafumi Ito, Kouichi Tamura, Yoshitaka Isaka, Hirokazu Okada, Kazuhiko Tsuruya, Hitoshi Yokoyama,
Naoki Nakashima, Hiromi Kataoka, Kazuhiko Ohe, Mihoko Okada, Naoki Kashihara, Prevalences of hyperuricemia andelectrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using
data

from

the

Japan

Chronic

KidneyDiseaseDatabase(J-CKD-DB),

PLoS

ONE,

15(10):e0240402,

doi:10.1371/journal.pone.0240402, 2020.10.

Tadashi Sofue, Naoki Nakagawa, Eiichiro Kanda, Hajime Nagasu, Kunihiro Matsushita, Masaomi Nangaku, Shoichi
Maruyama, Takashi Wada, Yoshio Terada, Kunihiro Yamagata, Ichiei Narita, Motoko Yanagita, Hitoshi Sugiyama, Takashi
Shigematsu, Takafumi Ito, Kouichi Tamura, Yoshitaka Isaka, Hirokazu Okada, Kazuhiko Tsuruya, Hitoshi Yokoyama,
Naoki Nakashima, Hiromi Kataoka, Kazuhiko Ohe, Mihoko Okada, Naoki Kashihara, Prevalence of anemia in patientswith chronic kidney disease in Japan: A nationwide, crosssectional cohort study using data from the Japan Chronic Kidney
Disease Database (JCKD-DB), PLoS ONE, 15(7): e0236132, doi:10.1371/journal.pone.0236132, 2020.07.

Keisuke Ido, Ryota Kurogi, Ai Kurogi, Kunihiro Nishimura, Koichi Arimura, Ataru Nishimura, Nice Ren, Akiko Kada,
Ryu Matsuo, Daisuke Onozuka, Akihito Hagihara, So Takagishi, Keitaro Yamagami, Misa Takegami, Yasunobu Nohara,
Naoki Nakashima, Masahiro Kamouchi, Isao Date, Takanari Kitazono, Koji Iihara, Effect of treatment modality andcerebral vasospasm agent on patient outcomes after aneurysmal subarachnoid hemorrhage in the elderly aged 75 years andolder, PLoS ONE, 15(4):e0230953, doi:10.1371/journal.pone.0230953, 2020.04.

Naoki Nakagawa, Tadashi Sofue, Eiichiro Kanda, Hajime Nagasu, Kunihiro Matsushita, Masaomi Nangaku, Shoichi
Maruyama, Takashi Wada, Yoshio Terada, Kunihiro Yamagata, Ichiei Narita, Motoko Yanagita, Hitoshi Sugiyama, Takashi
Shigematsu, Takafumi Ito, Kouichi Tamura, Yoshitaka Isaka, Hirokazu Okada, Kazuhiko Tsuruya, Hitoshi Yokoyama,
Naoki Nakashima, Hiromi Kataoka, Kazuhiko Ohe, Mihoko Okada, Naoki Kashihara, J-CKD-DB: a nationwide
multicentre electronic health record-based chronic kidney disease database in Japan, Scientific Reports,
doi:10.1038/s41598-020-64123-z, 2020.04.

Arakawa H, Shimojo N, Katoh N, Hiraba K, Kawada Y, Yamanaka K, Igawa K, Murota H, Okafuji I, Fukuie T, Nakahara
T, Noguchi T, Kanakubo A, Katayama I:
Consensus statements on pediatric atopic dermatitis from dermatology and pediatrics practitioners in Japan: Goals oftreatment and topical therapy.
Allergol Int 69(1):84-90, 2020

Takahagi S, Kamegashira A, Fukunaga A, Inomata N, Nakahara T, Hayama K, Hide M: Real-world clinical practices for
spontaneous urticaria and angioedema in Japan: A nation-wide cross-sectional web questionnaire survey.
Allergol Int. 69(2):300-303, 2020

Kaneko S, Tsuruta N, Yamaguchi K, Miyagi T, Takahashi K, Higashi Y, Morizane S, Nomura H, Yamaguchi M, Hino R,
Sawada Y, Nakamura M, Ohyama B, Ohata C, Yonekura K, Hayashi H, Yanase T, Matsuzaka Y, Sugita K, Kikuchi S,
Mitoma C, Nakahara T, Furue M, Okazaki F, Koike Y, Imafuku S; Western Japan Inflammatory Disease Research Group:
Mycobacterium tuberculosis infection in psoriatic patients treated with biologics:
Real- world data from 18 Japanese facilities.
J Dermatol 47(2):128-132. 2020

Furue K, Ito T, Tanaka Y, Hashimoto-Hachiya A, Takemura M, Murata M, Kido-Nakahara M, Tsuji G, Nakahara T, Furue
M:
The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients.
Int J Mol Sci. 21(2). pii: E434, 2020

Tsuji G, Hashimoto-Hachiya A, Yen VH, Takemura M, Yumine A, Furue K, Furue M, Nakahara T:
Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome inkeratinocytes: implications for preventing the development of psoriasis.
Cell Death Discov. 6:11. doi: 10.1038/s41420-020-0245-8. eCollection, 2020

Tsuji G, Hashimoto-Hachiya A, Yen VH, Miake S, Takemura M, Mitamura Y, Ito T, Murata M, Furue M, Nakahara T:
Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in
Keratinocytes via Ovo-Like 1.

J Clin Med. 9(3).pii: E891, 2020

Sato S, Chiba T, Nakahara T, Furue M:
Upregulation of IL-36 cytokines in folliculitis and eosinophilic pustular folliculitis. Australas J Dermatol 61(1):e39-e45,
2020

Eto A, Nakahara T, Kido-Nakahara M, Tsuji G, Furue M:
Acrosyringeal endothelin-1 expression: Potential for fostering melanocytes in volar sites.
J Dermatol 47(8):924-925, 2020

Kido-Nakahara M, Nakahara T, Yasukochi Y, Ulzii D, Furue M:
Patient-oriented Eczema Measure score: A Useful Tool for Web-Based Surveys in Patientswith Atopic Dermatitis.
Acta Derm Venereol doi: 10.2340/00015555-3530, 2020

Nakahara T, Kido-Nakahara M, Ulzii D, Miake S, Fujishima K, Sakai S, Chiba T, Tsuji G, Furue M:
Topical application of endothelin receptor A antagonist attenuates imiquimod-induced psoriasiform skin inflammation.
Sci Rep. 10(1):9510. doi: 10.1038/s41598-020-66490-z, 2020

Furue K, Ito T, Tsuji G, Nakahara T, Furue M:
Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytes.
J Dermatol Sci 99(3):209-212, 2020

Nakahara T, Izuhara K, Onozuka D, Nunomura S, Tamagawa-Mineoka R, Masuda K, Ichiyama S, Saeki H, Kabata Y, Abe
R, Ohtsuki M, Kamiya K, Okano T, Miyagaki T, Ishiuji Y, Asahina A, Kawasaki H, Tanese K, Mitsui H, Kawamura T,
Takeichi T, Akiyama M, Nishida E, Morita A, Tonomura K, Nakagawa Y, Sugawara K, Tateishi C, Kataoka Y, Fujimoto R,
Kaneko S, Morita E, Tanaka A, Hide M, Aoki N, Sano S, Matsuda-Hirose H, Hatano Y, Takenaka M, Murota H, Katoh N,
Furue M:
Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab: A study
protocol.
Medicine (Baltimore) 99(38):e22043. doi: 10.1097/MD.0000000000022043, 2020

Sagata N, Kano SI, Ohgidani M, Inamine S, Sakai Y, Kato H, Masuda K, Nakahara T, Nakahara-Kido M, Ohga S, Furue
M, Sawa A, Kanba S, Kato TA:
Forskolin rapidly enhances neuron-like morphological change of directly induced-neuronal cells from neurofibromatosis
type 1 patients.
Neuropsychopharmacol Rep 40(4):396-400, 2020

Vu YH, Hashimoto-Hachiya A, Takemura M, Yumine A, Mitamura Y, Nakahara T, Furue M, Tsuji G.
IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator:
Implication in the Treatment of Atopic Dermatitis.
Int J Mol Sci 21(24):E9412. doi: 10.3390/ijms21249412, 2020

Kido-Nakahara M, Wang B, Ohno F, Tsuji G, Ulzii D, Takemura M, Furue M, Nakahara T:
Inhibition of mite-induced dermatitis, pruritus, and nerve sprouting in mice by the endothelin receptor antagonist bosentan
Allergy 76(1):291-301, 2021

Chiba T, Nagai T, Kohda F, Nakahara T, Kono M:
The Connection between Urinary Equol Levels and the Prevalence of Atopic Dermatitis.
Int Arch Allergy Immunol 182(1):32-38, 2021

Takechi T, Hirota T, Fujii K, Nakahara T, Sakai T, Maeda N, Furue M, Ieiri I.
Effect of Genetic Polymorphisms of Human SLC22A3 in the 5'-flanking Region on OCT3 Expression and Sebum Levels
in Human Skin.
J Dermatol Sci 101(1):4-13, 2021

Thomas KS, Apfelbacher CA, Chalmers JR, Simpson E, Spuls PI, Gerbens LAA, Williams HC, Schmitt J, Gabes M,
Howells L, Stuart BL, Grinich E, Pawlitschek T, Burton T, Howie L, Gadkari A, Eckert L, Ebata T, Boers M, Saeki H,
Nakahara T, Katoh N.
Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic
eczema trials: results of the HOME VII consensus meeting.
Br J Dermatol doi: 10.1111/bjd.19751, 2021

Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima
M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H,
Ohya Y:
Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study.
Cytokine.Mar;6;130.2020.

Arima M, Akiyama M, Fujiwara K, Mori Y, Inoue H, Seki E, Nakama T, Tsukamoto S, Ochiai M, Ohga S, Sonoda K:
Neurodevelopmental outcomes after intravitreal bevacizumab injection in preterm infants with type 1 retinopathy ofprematurity in Japan.
JPN J Ophthalmol.Mar;20:15(3).2020.

Azuma Y, Suzuki Y, Okada S, Matsuguma C, Wakiguchi H, Ohnishi Y, Furuta T, Miyake A, Yasudo H, Ichihara K, Ohga
S, Hasegawa S:

Utility of soluble CD163 in the clinical management of patients with Kawasaki disease.
Front Pediatr.Apr;8:148.2020.

Iwanaka T, Yamaza T, Sonoda S, Yoshimaru K, Matsuura T, Yamaza H, Ohga S, Oda Y, Taguchi T:
A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver
fibrosis treatment.
Stem Cell Res Ther.Mar;11(1):134.2020.

Maeda M, Morimoto A, Shioda Y, Asano T, Koga Y, Nakazawa Y, Kanegane H, Kudo K, Ohga S, Ishii E,On behalf of theHistiocytosis study group of the Japanese Society of Pediatric Hematology/Oncology:
Long-term outcomes of children with extracutaneous juvenile xanthogranulomas in Japan.
Pediatr Blood Cancer.Jul;67(7).2020.

Yonese I, Sakashita C, Imadome K, Kobayashi T, Sawada A, Itoh Y, Fukuhara N, Hirose A, Takeda Y, Makita M, Endo T,
Kimura S, Ishimura M, Tomita M, Nakamura K, Miura O, Ohga S, Kimura H, Fujiwara S, Arai A:
Nationwide survey of chronic active EBV infection in Japan in accordance with the new WHO classification
Blood advances.Jul;4(13):2918-2926.2020.

Sagata N, Kano S, Ohgidani M, Inamine S, Sakai Y, Kato H, Masuda K, Nakahara T, Nakahara-Kido M, Ohga S, Furue M,
Sawa A, Kanba S, Kato T:
Forskolin rapidly enhances neuron-like morphological change of directly inducedneuronal (iN) cells fromneurofibromatosis type 1 (NF1) patients.
Neuropsychopharmacology Reports.Dec;40(4):396-400.2020.

Uike K, Saku K, Nishikawa T, Yamamura K, Ohga S, Tsutsui H, Sunagawa K:
Prediction of hemodynamics 1 after atrial septal defect closure using a framework of circulatory equilibrium in dogs.
AJP-Heart and Circulatory Physiology.Nov;319(5):H938-H947.2020.

Koyamaishi S, Kamio T, Kobayashi A, Sato T, Kudo K, Sasaki S, Kanezaki R, Hasegawa D, Muramatsu H, Takahashi Y,
Sasahara Y, Hiramatsu H, Kakuda H, Tanaka M, Ishimura M, Nishi M, Ishiguro A, Yabe H, Sarashina T, Yamamoto M,
Yuza Y, Hyakuna N, Yoshida K, Kanno H, Ohga S, Ohara A, Kojima S, Miyano S, Ogawa S, Toki T, Terui K, Ito E:
Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with
Diamond-Blackfan anemia.
Bone Marrow Transplant. May;56(5):1013-1020.2020.

Yamamoto-Shimojima K, Ogura H, Ohga S, Aoki T, Utsugisawa T, Takahashi H, Iwai A, Watanabe K, Okuno Y, Yoshida
K, Ogawa S, Miyano S, Kojima S, Yamamoto T, Kanno H:
Novel COL4A1 mutations identified in infants with congenital hemolytic anemia in association with brain malformations.

Human Genome Variation.Nov;7(1):42.2020.

Sonoda M, Ishimura M, Eguchi K, Shiraishi A, Kanno S, Kaku N, Inoue H, Motomura Y, Ochiai M, Sakai Y, Nakayama
M, Ohara O, Ohga S:
Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis.
Int J Hematol.Jan;111(1):131-136.2020.

Furuta T, Yasudo H, Ohnishi Y, Miyake A, Okada S, Suzuki Y, Ohga S, Hasegawa S:
The efficacy of infliximab as a third-line therapy for refractory Kawasaki disease
Pediatr Infect Dis J.Aug;39(8).2020.

Inoue H, Matsushige T, Ichiyama T, Okuno A, Takikawa O, Tomonaga S, Anlar B, Yükse D, Otsuka Y, Kouno F, Hoshide
M, Ohga S, Hasegawa S:
Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis.
J Neuroimmunol.Feb;339:577088.2020.

Akamine S, Okuzono S, Yamamoto H, Setoyama D, Sagata N, Ohgidani H, Kato AT, Ishitani T, Kato H, Masuda K,
Matsushita Y, Ono H, Ishizaki Y, Sanefuji M, Saitsu H, Matsumoto N, Kang D, Kanba S, Nakabeppu Y, Sakai Y, Ohga S:
GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.
FASEB J.Dec;34(12):16601-16621.2020.

Kurokawa M, Torio M, Ohkubo K, Tocan V, Ohyama N, Toda N, Ishii K, Nishiyama K, Mushimoto Y, Sakamoto R, Nakaza
M, Horie R, Kubota T, Takahashi MP, Sakai Y, Nomura M, Ohga S:
The expanding phenotype of hypokalemic periodic paralysis in a Japanese family with p.Val876Glu mutation in CACNA1S.
Mol Genet Genomic Med.Apr;8(4):e1175. 2020.

Myoga M, Tsuji M, Tanaka R, Shibata E, Askew DJ, Aiko Y, Senju A, Kawamoto T, Hachisuga T, Araki S, Kusuhara K,
Morokuma S, Sanefuji M; Japan Environment and Children’s Study:
Impact of sleep duration during pregnancy on the risk of gestational diabetes in the Japan environmental and Children's
study (JECS).
BMC Pregnancy Childbirth.Dec;9;19(1):483.2019.

Nakayama SF, Isobe T, Iwai-Shimada M, Kobayashi Y, Nishihama Y, Taniguchi Y, Sekiyama M, Michikawa T, Yamazaki
S, Nitta H, Oda M, Mitsubuchi H, Sanefuji M, Ohga S, Mise N, Ikegami A, Suga R, Shimono M:
Poly- and perfluoroalkyl substances in maternal serum: Method development and application in Pilot Study of the Japan
Environment and Children's Study.
J Chromatogr A.May;1618:460933.2020.

Taniguchi Y, Yamazaki S, Michikawa T, Nakayama SF, Sekiyama M, Nitta H, Mezawa H, Saito-Abe M, Oda M, Mitsubuchi
H, Sanefuji M, Ohga S, Mise N, Ikegami A, Shimono M, Suga R:
Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment andchildren's study.
PLoS One.May;15(5):e0232604.2020.

Torio M, Iwayama M, Sawano T, Inoue H, Ochiai M, Taira R, Yonemoto K, Ichimiya Y, Sonoda Y, Sasazuki M, Ishizaki
Y, Sanefuji S, Yamane Y, Yamashita H, Torisu H, Kira R, Hara T, Kanba S, Sakai Y, Ohga S:
Neurodevelopmental outcomes of high-risk preterm infants: A prospective study in Japan.
Neurol Clin Pract (in press)

Kudo K, Maeda M, Suzuki N, Kanegane H, Ohga S, Ishii E, Shioda Y, Imamura T, Imashuku S, Tsunematsu Y, Endo M,
Shimada A, Koga Y, Hashii Y, Noguchi M, Inoue M, Tabuchi K, Morimoto A; Histiocytosis study group of the JapaneseSociety of Pediatric Hematology/Oncology:
Nationwide retrospective review of hematopoietic stem cell transplantation in children with refractory Langerhans cellhistiocytosis.
Int J Hematol.111(1):137-148.2020.

Murata K, Hoshina T, Onoyama S, Tanaka T, Kanno S, Ishimura M, Koga Y, Nakayama H, Ohga S:
Reduction in the number of varicella-zoster virus-specific T-cells in immunocompromised children with varicella.
Tohoku J Exp Med.250:181-190.2020.

Ochiai M, Kurata H, Inoue H, Ichiyama M, Fujiyoshi J, Watabe S, Hiroma T, Nakamura T, Ohga S:
Transcutaneous blood gas monitoring among neonatal intensive care units in Japan
Pediatr Int.Feb;62(2):169-174.2020.

Arima M, Akiyama M, Fujiwara K, Mori Y, Inoue H, Seki E, Nakama T, Tsukamoto S, Ochiai M, Ohga S, Sonoda KH:
Neurodevelopmental outcomes following intravitreal bevacizumab injection in Japanese preterm infants with type 1
retinopathy of prematurity
PLoS One.Mar;15(3):e0230678.2020.

Taira R, Inoue H, Sawano T, Fujiyoshi J, Ichimiya Y, Torio M, Sanefuji M, Ochiai M, Sakai Y, Ohga S:
Management of apnea in infants with trisomy 18
Dev Med Child NeurolJul;62(7):874-878.2020.

Nagata H, Sakamoto I, Fukuoka S, Ishikita A, Uike K, Nagatomo Y, Hirata Y, Yamamura K, Ohga S:
Portosystemic venous shunt in the patients with Fontan circulation.
Heart Vessels 2020 doi: 10.1007/s00380-020-01685-y

Imai T, Shiraishi A, Nishiyama K, Ishimura M, Ohga S:
Lipopolysaccharide-induced monocyte death in a novel ZnF7 domain mutation of TNFAIP3.
J Allergy Clin Immunol Pract.Jun;8(6):2071-2074.2020.

Imai T, Nishiyama K, Ueki K, Tanaka T, Kaku Y, Hara T, Ohga S:
Involvement of activated cytotoxic T lymphocytes and natural killer cells in Henoch-Schönlein purpura nephritis.
Clin Transl Immunology.Nov;9(11):e1212.2020.

Kurokawa M, Nishiyama K, Koga Y, Eguchi K, Imai T, Oba U, Shiraishi A, Nagata H, Kaku N, Ishimura M, Honjo S,
Ohga S:
Hyperferritinemia and acute kidney injury in pediatric patients receiving allogeneic hematopoietic cell transplantation.
Pediatr Nephrol.Oct;35(10):1977-1984.2020.

Nishiyama K, Watanabe Y, Ishimura M, Tetsuhara K, Imai T, Kanemasa H, Ueki K, Motomura Y, Kaku N, Sakai Y,
Imadome KI, Ohga S:
Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis.
Open Forum Infect Dis.Jul;7(8):ofaa288.2020.

Junichiro Tezuka, Masafumi Sanefuji, Takahito Ninomiya, Takahiro Kawahara, Hiroshi Matsuzaki, Yuri Sonoda,
Masanobu Ogawa, Masayuki Shimono, Reiko Suga, Satoshi Honjo, Koichi Kusuhara, Shouichi Ohga
Possible association between early formula and reduced risk of cow's milk allergy: The Japan Environment and Children's
Study
Clin Exp Allergy. Jan;51(1):99-107. 2021.

【２】総 説篠田あかり、渡邉麻衣、Therdththa Phatthanaphong, 中山二郎. アジア人の食習慣と腸内細菌叢の変化と現代生
活習慣病リスク向上の関連性について, 実験医学(増刊)個人差の理解へ向かう肥満症の研究、39(5), 787-794,
2021.

Toshiro Matsui, Atsuko Yoshino, and Mitsuru Tanaka: A trip of peptides to the brain. Food Production, Processing andNutrition, 2, 30 (2020).

Masuda K, Han X, Kato H, Sato H, Zhang Y, Sun X, Hirofuji Y, Yamaza H, Yamada A, Fukumoto S. Share Dental PulpDerived Mesenchymal Stem Cells for Modeling Genetic Disorders. Int J Mol Sci. 22(5):2269. 2021

安尾しのぶ 「肥満・メタボリックシンドロームと時間栄養学」 アグリバイオ 4, 13-17. (2020)

中島 直樹, リアルワールドデータを用いた臨床薬理学, 20(12):58-64, 2021.03.

Furue K, Ito T, Tsuji G, Nakahara T, Furue M:
The CCL20 and CCR6 axis in psoriasis.
Scand J Immunol. 91(3):e12846, 2020

Furue M, Ulzii D, Nakahara T, Tsuji G, Furue K, Hashimoto-Hachiya A, Kido-Nakahara M:
Implications of IL-13Rα2 in atopic skin inflammation.
Allergol Int. pii: S1323-8930(20)30011-3, 2020

Furue M, Furue K, Tsuji G, Nakahara T:
Interleukin-17A and Keratinocytes in Psoriasis.
Int J Mol Sci. 21(4). pii: E1275, 2020

Furue K, Ulzii D, Tanaka Y, Ito T, Tsuji G, Kido-Nakahara M, Nakahara T, Furue M:
Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis
J Dermatol. 47(9):979-988, 2020

Furue M, Nakahara T:
Revival of AHR Agonist for the Treatment of Atopic Dermatitis: Tapinarof
Current Treatment Options in Allergy. Volume, 7, pages414–421, 2020

Nakahara T, Kido-Nakahara M, Tsuji G, Furue M:
Basics and recent advances in the pathophysiology of atopic dermatitis.
J Dermatol 48(2):130-139, 2021

白石暁、江口克秀、石村匡崇、神野俊介、古賀友紀、大賀正一:
小児がん治療における特殊な重症感染症シリーズ:(1)抗酸菌 小児の血液・がん疾患に合併した難治性抗酸菌感
染症の治療方針について
日本小児血液・がん学会雑誌 56(5) 388-392,2020

石村匡崇、落合正行、大賀正一：
特集 診断・治療可能な遺伝性疾患を見逃さないために 各論Ⅳ遺 血液・免疫性疾患 3．遺伝性血栓症
小児科臨床 73 巻 5 号 749-752,2020

市山正子、石村匡崇、落合正行：

小児期から発症する血栓症とその素因
日本医事新報 5014 48-48,2020

落合正行、大賀正一：血栓止血学の新知見 ３．新生児の血栓症
日本新生児成育医学会雑誌 32(1) 52-56,2020
落合正行：【必携】専攻医と指導医のための新生児診療到達目標 テーマ：〈疾患別到達目標〉３．呼吸器疾患 ２）新生児一過性多呼吸周産期医学 50(4) 571-573,2020

落合正行：
NICU から始まる小児在宅医療の新しい課題 【各論】６．地域で取り組む小児在宅医療とその課題 福岡県における医療的ケア児の診療課題と医療提供体制構築への取り組み
周産期医学 50(5) 862-866,2020

落合正行：
NEO SPOT 「第 64 回日本新生児成育医学会・学術集会」第 64 回日本新生児成育医学会・学術集会＠鹿児島レ
ポートwith NEO 33(2) 136-137,2020

落合正行、石村匡崇、大賀正一：
特集 周産期の薬《新生児編》７．血液疾患・免疫疾患 ４）血小板減少症
周産期医学 50,2020

落合正行：
乳幼児期の貧血
小児科 61(11) 1475-1480,2020

落合正行：
新生児期の貧血
雑誌「小児科診療」増刊号 〜エキスパートの経験に学ぶ〜小児科 Decision Making, 2020

落合正行：
自然災害時の在宅療養の受け入れ
丹々会会報 45:28-30,2020

【３】著 書
福本 敏．COLOR ATLAS 子どもの健やかなお口をつくる GP のための小児の歯科診療 第 II 章<各論＞４章 咬合誘導 松風歯科クラブ会員用 No.５０（監著：木本茂成／福本 敏） 140-155，2020
山座治義．COLOR ATLAS 子どもの健やかなお口をつくる GP のための小児の歯科診療 第 II 章<各論＞５章 口腔機能の育成 １授乳・離乳の指導 松風歯科クラブ会員用 No.５０（監著：木本茂成／
福本 敏） 156-167，2020
新垣真紀子, 日野綾子, 山座治義, 山田亜矢, 福本敏．特別企画 S-PRG の効果的な活用法-その作用とは？
どんな効果があるのか？-（Part2）S-PRG の効果的な活用方（CASE3）シーラントでの活かし方 日本歯科評論 80(3) 101-104 2020 年
Editor: Pradeep Kumar Ray, Naoki Nakashima, Ashir Ahmed, Soong-Chul Ro, Yasuhiro Soshino, Mobile
Technologies for Delivering Healthcare in Remote, Rural or Developing Regions, The Institution of Engineering andTechnology, 2020.10.
Ashir Ahmed, Mehdi Hasan, Masuda Begum Sampa, Kazi Mozaher Hossein, Yasunobu Nohara, Naoki Nakashima,
Mobile Technologies for Delivering Healthcare in Remote, Rural or Developing Regions
Chapter7: Portable health clinic: concept, design, implementation and challenges, The Institution of Engineering andTechnology, 105-121, 2020.10.
大賀正一：
小児の紫斑・出血傾向
今日の診断指針 第 8 版
pp.60-66, 医学書院 2020
森本 哲、石井榮一、大賀正一、金兼弘和、塩田曜子、八角高裕、中沢洋三、園田素史、清水正樹、古賀友紀、浅野健、工藤寿子：
小児 HLH 診療ガイドライン 2020 Vr. 1.0.
日本小児血液・がん学会 組織球症委員会 2020
中島康貴、 山村健一郎、酒井康成、大賀正一、原寿郎：II.病因・病態解明 2「リピドミクス解析から」特集「川崎病の今」小児内科 53 巻 1 号 (印刷中)
落合正行：
早産児の貧血今日の治療指針 2020 年版－私はこう治療している
医学書院 2020
落合正行：
低酸素性虚血脳症の子どもへの医療の視点からの配慮
医療的ケア児支援者養成研修テキスト,2020

落合正行、浦部由紀：
新生児のフィジカルアセスメント 血液のアセスメント 出血傾向
NICU ナース my ポケノート
pp.108－112,メディカ出版 2020

【４】症例報告
Tobai H, Yano J, Sato N, Amanuma F, Takahashi M, Endo M, Ishimura M, Ohga S, Maruyama H.
Successful Liposteroid Therapy for a Recurrent Idiopathic Pulmonary Hemosiderosis with Down Syndrome.
Case Rep Pediatr.Apr;2020:5292947.2020.
Yada Y, Koga Y, Ono H, Motomura Y, Komiya K, Kohashi K, Kameiu K, Taguchi T, Oda Y, Ohga S:
Acute isolated Aspergillus appendicitis in pediatric leukemia
J Infect Chemother.Nov;26(11):1229-1231.2020.
Shiraishi T, Yanagida H, Koga Y, Ohga S, Fujita M, Hiratsuka M, Miyahara S, Waseda R, Sato T, Iwasaki A:
Severe scoliosis with an impaired pulmonary allograft function after pediatric unilateral lung transplantation.
Gen Thorac Cardiovasc Surg 2020 in press
Okazaki F, Wakiguchi H, Korenaga Y, Nakamura T, Yasudo H, Uchi S, Yanai R, Asano N, Hoshii Y, Tanabe T, Izawa
K, Honda Y, Nishikomori R, Uchida K, Eishi Y, Ohga S, Hasegawa S:
A novel mutation in early-onset sarcoidosis/Blau syndrome: an association with Propionibacterium acnes.
Pediatr Rheumatol 2020 in press
Kinoshita K, Ishizaki Y, Yamamoto H, Sonoda M, Yonemoto K, Kira R, Sanefuji M, Ueda A, Matsui H, Ando Y,
Sakai Y, Ohga S:
De novo p.G696S mutation in COL4A1 causes intracranial calcification and late-onset cerebral hemorrhage: A casereport and review of the literature.
Eur J Med Genet.Apr;63(4):103825.2020.
Oyama N, Kojima-Ishii K, Toda N, Matsuo T, Tocan V, Ohkubo K, Oba U, Koga Y, Setsu N, Yamada Y, Kohashi K,
Nakashima Y, Oda Y, Ihara K, Ohga S:
Malignant transformation of phosphaturic mesenchymal tumor: a case report and literature review.
Clin Pediatr Endocrinol.29(2):69-75.2020.
Nishiyama K, Kurokawa M, Torio M, Sakai Y, Arima M, Tsukamoto S, Obata S, Minamikawa S, Nozu K, Kaku N,
Maehara Y, Sonoda KH, Taguchi T, Ohga S:
Gastrointestinal symptoms as an extended clinical feature of Pierson syndrome: a case report and review of theliterature.
BMC Med Genet.Apr;21(1):80.2020.
Yoshimaru K, Matsuura T, Yanagi Y, Takahashi Y, Kohashi K, Kaku N, Oda Y, Ohga S, Taguchi T:

Successful Urgent Living Donor Liver Transplantation for Massive Liver Necrosis Accompanied by Nonocclusive
Mesenteric Ischemia in a Biliary Atresia Infant: A Case Report.
Transplant Proc.52:2802-2808.2020.
山座治義，髙山扶美子，小笠原貴子，廣藤雄太，廣藤早紀，木舩 崇，佐藤綾子，香川由依，増田啓次，
福本 敏, 病診連携により施行できた Noonan 症候群患児の心臓手術前の口腔内感染源への歯科治療の一例, 日本障害者歯科学会誌, 41(4):318-323, 2020
Eto A, Nakahara T, Furue M.
Repeated infliximab injection may shift delayed infusion reactions to acute infusion reactions in patients withpsoriasis.
J Dermatol 48(1):e41-e42, 2021