Workflow Guide

freeslate jr.

Process chemistry
Walk up, set up your run and walk away. Freeslate jr. turns
reaction screening and process optimization into totallyroutine activities. Build a system for reaction screening andplow through hundreds of modifications per week. Deckone out with real-time sampling to fine tune your chemistry
pathways. Freeslate jr. lets you dive deep so you know
exactly what tweaks to make next.

Applications• Process optimization• Identify high yield conditions
freeslate jr. configured for reaction optimization• Reaction screening and optimization• Screen continuous variables such as equivalents,concentrations, temperatures, pressures and time
• Screen discrete variables such as catalyst precursors,ligands and solvents• Optimize and screen new synthetic routes• Improve yields and impurity profiles• Optimize catalyst loading• Map process robustness

Key features

Optimization sampling reactor (OSR)• Rapid, real-time reaction kinetics• Process control of 8 individual reactions withindependent pressure and temp control• Fully automated in-situ reagent addition and slurrysampling under pressure• Execute up to 96 pressurized reactions such ashydrogenation (with optional SPR or DSPR)• Overhead stirring for complete reaction mixing• Accurate and automated dosing of small quantities ofsolid, liquid or slurry reagents• Control heating, stirring, and vortexing in vials or
microtiter plates

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• Provide an inert atmosphere for air-sensitive chemistries
Example freeslate jr. deck configured for reaction optimization
1 Solvent tray
2 OSR
3 3-position vortexing station

4 Wash station
5 Heating/cooling/stirring bay
6 3-position plate rack

Workflow Guide

Available optionsHeated 4-tip liquid dispenser – extended tip

Solid dispense

Heated reservoir volume per tip: 1 mL
Reservoir temperature: Up to 120 °C
Temperature uniformity: ±2 °C (across tips)
Tip pitch: 9 mm
Extendible tip: 1Syringe sizes: 50 µL – 2.5 mL (standard supplied)

Dispense technology: Dispense algorithm dynamically controls thedispensing head to adjust for powders with different densities,
particle sizes, particle shapes and static charges• Classic powder dispense: Traditional stirrer dispense mechanism• Hopper volume range: 10–100 mL• Storage vial (SV) powder dispense: Unique vibratory dispensing
mechanism for highly precise dispensing of small amounts as
low as 0.5 mg• Hopper volume: 4 mL

Heated single-tip liquid dispenser
Heated reservoir volume: 1 mL
Reservoir temperature: Up to 120 °C
Syringe sizes: 1–2.5 mL (standard)
Needle size: 16 gauge, non-piercing

Vortexing station — 3 positions
Orbital: Up to 2000 rpm
Maximum vortexing mass: 860 g

pH measurement
Configuration: Single or 4-channel probe
Measurement time per 96-well plate: ~34 minutes
Range: pH 1–13
Resolution: 0.01 pH units
Repeatability: ±0.1 pH units

Deck screening pressure reactor (DSPR)
Max pressure rating: 200 psi @ 180 °C
Pressure drop: <5 psi/hr

Heated single-tip liquid dispenser
Heated reservoir volume per tip: 1 mL
Reservoir temperature: Up to 120 °C
Syringe sizes: 1–2.5 mL (standard)
Needle size: 16 gauge, non-piercing

Optimization sampling reactor and sampling arm
Temperature rating: -20–200 °C
Reactors: 8 independent reactors
Possible delta between adjacent reactors: >80 °C
Heating and cooling rate: >10 °C/min
Pressure rating: Ambient to 400 psi
Maximum overhead stirring speed: 750 rpm
Reactor total volume: 40 mL
Reactor working volume: 25 mL

Unchained Labs
6940 Koll Center Pkwy, Suite 200
Pleasanton, CA 94566
Phone: 1.925.587.9800
Toll-free: 1.800.815.6384
Email: info@unchainedlabs.com

Balance with integrated camera
Maximum weight:• Standard: 1200 g• High-sensitivity option: 220 g
Sensitivity:• Standard: 0.1 mg• High sensitivity option: 0.01 mg
Resolution:• Standard: 0.1 mg• High-sensitivity option:• 0.01 mg (0–110 g)• 0.1 mg (110–220 g)
Repeatability:• Standard:• High weight (measured >200 g): 0.25 mg• Low weight (measured up to 200 g): 0.15 mg• High-sensitivity option:• High weight (measured at 200 g): 0.15 mg• Low weight (measured at 10 g): 0.04 mg
Response time: <22s
Camera resolution: 1032 pixels (max wide) x 779 pixels (tall)

Off-deck third-party instrument integration• HPLC• GC
Other systems available for virtual integration.
Please contact Unchained Labs for a full list of systems.

Facilities requirements
Physical:With integrated enclosure:
105 cm W x 90.4 cm D x 140 cm H, ~150 kg
With integrated table option:
167 cm W x 90,4 cm D x 200 cm H, ~240 kg
Electrical:
freeslate jr.:
120–220 V ±10 %, 50–60 Hz, 16 A
Computer:
US: 115 V ±10 %, 60 Hz
EU: 220 V ±10 %, 50 Hz
Compressed dry air: 0.5 MPa to 0.9 MPa (70–130 psi), 16 L/min(8 mm hose)© 2016 Unchained Labs. All rights reserved. Freeslate jr. is atrademark and Unchained Labs is a registered trademark ofUnchained Labs. All other brands or product names mentioned aretrademarks owned by their respective organizations.