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Calcium Chloride ,JUNSEI CHEMICAL CO., LTD.,18229jis_E-2,06/Nov/2023
Date of issue for the 1st edition : 02/Aug/2017
Date of revision : 06/Nov/2023

Safety Data Sheet

Section 1. Identification of the substance/mixture and of the company/undertaking
Product identifier:Product name: Calcium Chloride
Reference number(SDS):18229jis_E-2
Product type：
Food Additives※This product conform to JSFA(Japan's Specifications and Standards for Food Additives).
Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses of the product: Dietary supplements for use in Japan only
Uses advised against: Only when indispensable for manufacturing or processing the food, or whenused for nutritive purposes.
Maximum Limits=1.0%(as Ca) (Excluding foods labelled for special uses)
Details of the supplier of the safety data sheet
Manufacturer/Supplier: JUNSEI CHEMICAL CO., LTD.
Address: 1-6, Ohmano-Cho, Koshigaya, Saitama 343-0844, Japan
Division: Quality Assurance Department
Telephone number: +81-48-986-6161
FAX: +81-48-989-2787
e-mail address: shiyaku-t@junsei.co.jp

Section 2. Hazards identification
GHS classification and label elements of the product
Classification of the substance or mixture
HEALTH HAZARDS
Acute toxicity (Oral): Category 4Serious eye damage/eye irritation: Category 1
Specific target organ toxicity - single exposure: Category 3 (Respiratory tract irritation)
Specific target organ toxicity - repeated exposure: Category 2 (blood system)(Note) GHS classification without description: Not classified/Classification not possible
Label elements

Signal word: Danger
HAZARD STATEMENT
H302-Harmful if swallowed
H318-Causes serious eye damage
H335-May cause respiratory irritation
H373-May cause damage to organs through prolonged or repeated exposure
PRECAUTIONARY STATEMENT
Prevention
Do not breathe dust/fume/gas/mist/vapors/spray.
Use only outdoors or in a well-ventilated area.
Wash contaminated parts thoroughly after handling.
Wear eye protection/face protection.
Do not eat, drink or smoke when using this product.

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Response
Get medical advice/attention if you feel unwell.
Immediately call a POISON CENTER/doctor/physician.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF INHALED: Remove person to fresh air and keep comfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
IF SWALLOWED: Rinse mouth. Call a POISON CENTER/doctor/physician if you feel unwell.
Storage
Store in a well-ventilated place. Keep container tightly closed.
Store locked up.
Disposal
Dispose of contents/container in accordance with local/national regulation.

Section 3. Composition/information on ingredients
Mixture/Substance selection:
Substance
Ingredient name:Calcium chloride dihydrate
Content (%):(as CaCl2)70.0 <Chemical formula:CaCl2・2H2O
Chemicals No, Japan:1-176
CAS No.:10035-04-8 [10043-52-4(anh)]
MW:147.01
ECNO:233-140-8(anh)Note : The figures shown above are not the specifications of the product.

Section 4. First-aid measures
Descriptions of first-aid measures
General measures
Get medical advice/attention if you feel unwell.
Immediately call a POISON CENTER/doctor/physician.
IF INHALED
Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF ON SKIN (or hair）
Take off immediately all contaminated clothing. Rinse skin with water or shower.
If skin irritation or rash occurs: Get medical advice/attention.
IF IN EYES
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED
Rinse mouth. Do NOT induce vomiting.
If victim is conscious, give 1 - 2 glasses of water.
Call a POISON CENTER/doctor/physician if you feel unwell.
Most important symptoms and effects, both acute and delayedSpecific information on symptom and effect are unknown.
Indication of any immediate medical attention and special treatment needed
Information on indication of any immediate medical attention and special treatment needed
is not available.

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Calcium Chloride ,JUNSEI CHEMICAL CO., LTD.,18229jis_E-2,06/Nov/2023
Section 5. Fire-fighting measures
Extinguishing media
Suitable extinguishing media
Use appropriate extinguishing media suitable for surrounding facilities.
The product is non-flammable.
Unsuitable extinguishing media
Unsuitable extinguishing media data is not available.
Specific hazards arising from the substance or mixture
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may cause pollution.
Advice for firefighters
Specific fire-fighting measures
Evacuate non-essential personnel to safe area.
Special protective equipment and precautions for fire-fighters
Wear fire resistant or flame retardant clothing.
Wear protective gloves/protective clothing/eye protection/face protection.
Firefighters should wear self-contained breathing apparatus with a full facepiece operated
in the positive pressure mode.

Section 6. Accidental release measures
Personnel precautions, protective equipment and emergency procedures
Ventilate area until material pick up is complete.
Wear proper protective equipment.
Environmental precautions
Avoid release to headsprings, rivers, lakes, ocean and groundwater.
Methods and materials for containment and cleaning up
Sweep up, place in a bag and hold for waste disposal.
Preventive measures for secondary accident
Collect spillage.

Section 7. Handling and storage
Precautions for safe handling
Preventive measures(Exposure Control for handling personnel)
Do not breathe dust/fume/gas/mist/vapors/spray.
(Protective measures against fire and explosion)
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
(Exhaust/ventilator)
Exhaust/ventilator should be available.
(Safety treatments)
Avoid contact with skin.
Avoid contact with eyes.
Safety Measures
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
When using do not eat, drink or smoke.
Any incompatibilitiesStrong oxidizing agents, Water should not be mixed with the chemicals.

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Advice on general occupational hygiene
Wash contaminated parts thoroughly after handling.
Do not eat, drink or smoke when using this product.
Storage
Conditions for safe storage
Store in a well-ventilated place. Keep container tightly closed.
Keep cool. Protect from sunlight.
Store in accordance with local/national regulation.
Store locked up.
Container and packaging materials for safe handling data is not available.
Specific end use(s)See information in Section 7.1 and 7.2 for handling and storage recommendations. See
Section 8 for exposure controls and personal protection recommendations.

Section 8. Exposure controls/personal protection
Control parameters
Control value in MHLW is not available.
Adopted value
Adopted value in JSOH is not available.
Adopted value in ACGIH is not available.
Exposure controls
Appropriate engineering controls
Do not use in areas without adequate ventilation.
Eye wash station should be available.
Washing facilities should be available.
Individual protection measures
Respiratory protection
Wear respiratory protection.
Recommended respiratory protection：Self-Contained Breathing Apparatus (SCBA)
Hand protection
Wear protective gloves.
Inspect before use and replace worn or damaged gloves.
Contact the glove manufacturer for specific advice on glove selection and breakthroughtimes for your use conditions.
Chemical-resistant, impervious gloves complying with an approved standard (e.g. JIS T8116)
should be used.
Eye protection
Wear safety glasses with side-shields.
Wear eye/face protection.
Skin and body protection
Wear impervious clothing and boots in case of repeated or prolonged treatment.
Personal protective equipment for the body and skin should be selected based on the task
being performed and the risks involved.

Section 9. Physical and Chemical Properties
Information on basic physical and chemical properties
Physical state: Crystal, powder, flakes, granules or lumps
Color: WhiteOdor: Odorless
Odor threshold data is not available.
Melting point/Freezing point: 176℃(Loss of crystalline water)
Boiling point or initial boiling point data is not available.

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Calcium Chloride ,JUNSEI CHEMICAL CO., LTD.,18229jis_E-2,06/Nov/2023
Boiling range data is not available.
Flammability (gases, liquids and solids): Non-flammable
Lower and upper explosion limit/flammability limit data is not available.
Flash point: Non-flammableAuto-ignition temperature data is not available.
Decomposition temperature data is not available.
Self-Accelerating Decomposition Temperature/SADT data is not available.
pH: 4.5～9.0 (50g/L, 25℃)
Dynamic viscosity data is not available.
Kinematic viscosity data is not available.
Solubility:
Solubility in water: Very soluble
Solubility in solvent: Soluble in ethanol (99.5).
n-Octanol/water partition coefficient data is not available.
Vapor pressure data is not available.
Density and/or relative density: 1.85g/cm3(25℃)
Relative vapor density (Air=1) data is not available.
Relative density of the Vapor/air - mixture at 20℃ (Air = 1) data is not available.
Particle characteristics data is not available.
Other information
Critical temperature data is not available.
Evaporation rate data is not available.
VOC data is not available.

Section 10. Stability and Reactivity
Reactivity
Reactivity data is not available.
Chemical stability
Stable under normal storage/handling conditions.
Hygroscopic.
Possibility of hazardous reactions
Decomposes on heating. This produces toxic and corrosive fumes.
Attacks zinc in the presence of water. This produces flammable/explosive gas.
Dissolves in water with liberation of much heat.
Conditions to avoid
Contact with incompatible materials.
Moisture, Heating.
Incompatible materials
Strong oxidizing agents, Water.
Hazardous decomposition products
Calcium oxides, Chlorides

Section 11. Toxicological Information
Information on toxicological effects
Acute toxicity
Acute toxicity (Oral)[Product]Category 4, Harmful if swallowed[Data for components of the product][GHS Cat. Japan, base data](Calcium chloride)
female rat LD50=1940mg/kg (SIDS, Access on Dec. 2008)

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Calcium Chloride ,JUNSEI CHEMICAL CO., LTD.,18229jis_E-2,06/Nov/2023
Acute toxicity (Dermal)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Acute toxicity (Inhalation)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Irritant properties
Skin corrosion/irritation[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Serious eye damage/irritation[Product]Category 1, Causes serious eye damage[Data for components of the product][GHS Cat. Japan, base data](Calcium chloride)human : severe irritation (SIDS, Access on Dec. 2008)
Sensitization
Respiratory sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Skin sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Germ cell mutagenicity[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product][GHS Cat. Japan, base data](Calcium chloride)
No in vivo data available.
Reverse-mutation assay in bacteria (Ames test) :Negative（SIDS, Access on Dec. 2008)
Chromosome aberration test :Negative（SIDS, Access on Dec. 2008)
Carcinogenicity[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Reproductive toxicity[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.

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Calcium Chloride ,JUNSEI CHEMICAL CO., LTD.,18229jis_E-2,06/Nov/2023
Specific target organ toxicity (STOT)
STOT-single exposure[Product]Category 3, May cause respiratory irritation[Data for components of the product][cat.3 (respiratory tract irritation)][GHS Cat. Japan, base data](Calcium chloride)
respiratory tract irritation (SIDS, Access on Dec. 2008)
STOT-repeated exposure[Product]Category 2, May cause damage to organs through prolonged or repeated exposure[Data for components of the product][cat.2][GHS Cat. Japan, base data](Calcium chloride)
blood system (SIDS, Access on Dec. 2008)
Aspiration hazard[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Information on other hazards
Reference data : Anhydrous of this product(CAS No. 10043-52-4)

Section 12. Ecological Information
Toxicity
Aquatic toxicity[Product]
Based on available data, the classification criteria are not met.
[Data for components of the product]
Hazardous to the aquatic environment, short-term (acute)[GHS Cat. Japan, base data](Calcium chloride)
Fish, Algae, Crustacea LC/EC50 >100mg/L (SIDS, 2005)
Water solubility[Data for components of the product](Calcium chloride)
74.5 g/100 ml (20℃) (ICSC, 2012)
Persistence and degradability
Persistence and degradability data is not available.
Bioaccumulative potential
Bioaccumulative potential data is not available.
Mobility in soil
Mobility in soil data is not available.
Other adverse effects
Ozone depleting chemical data is not available.
Additional information
Reference data : Anhydrous of this product(CAS No. 10043-52-4)

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Section 13. Disposal considerations
Description of waste residues and information on their safe handling and methods of disposal,
including the disposal of any contaminated packaging
Waste treatment methods
Dispose of contents/container in accordance with local/national regulation.

Section 14. Transport Information
UN No., UN CLASS
UN Number or ID Number : Not regulated
UN Proper Shipping Name : Not regulated
Class or division (Transport hazard class) : Not regulated
Packing group : Not regulated
IMDG Code (International Maritime Dangerous Goods Regulations)
UN Number or ID Number : Not regulated
UN Proper Shipping Name : Not regulated
Class or division (Transport hazard class) : Not regulated
Packing group : Not regulated
IATA (Dangerous Goods Regulations)
UN Number or ID Number : Not regulated
UN Proper Shipping Name : Not regulated
Class or division (Transport hazard class) : Not regulated
Packing group : Not regulated
Environmental hazards
Marine pollutants (yes/no) : noSection 15. Regulatory Information
Safety, health and environmental regulations/legislation specific for the substance or mixture
U.S. Toxic Substances Control Act (TSCA) Inventory
Chemicals listed in TSCA Inventory
10035-04-8 [10043-52-4(anh)]
All components are listed or exempted.
Other regulatory information
We are not able to check up the regulatory information with regard to the substances inyour country or region, therefore, we request this matter would be filled by yourresponsibility.
Regulatory information with regard to this substance in your country or in your region
should be examined by your own responsibility.
Ensure this material in compliance with federal requirements and ensure conformity to local
regulations.
Regulatory information in this section are limited to intentional ingredient(s), but does
not contain information on non-intentional ingredients or impurities which are not informedby supplier(s).
Chemical safety assessment
Advice on safe handling for this product can be found in sections 7 and 8 of this SDS.

Section 16. Other information
GHS classification and labelling
H302-Acute toxicity, Category 4: H302 Harmful if swallowed
H318-Serious eye damage/eye irritation, Category 1: H318 Causes serious eye damage
H335-STOT - single exposure, Category 3, Respiratory tract irritation: H335 May cause

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respiratory irritation.
H373-STOT - Repeated exposure, Category 2: H373 May cause damage to organs throughprolonged or repeated exposure
References and sources for data
Globally Harmonized System of classification and labelling of chemicals, UN
Recommendations on the TRANSPORT OF DANGEROUS GOODS 22nd edit., 2021 UN
IMDG Code, 2020 Edition (Incorporating Amendment 40-20)
IATA Dangerous Goods Regulations (64th Edition) 2023
2020 EMERGENCY RESPONSE GUIDEBOOK (US DOT)
2023 TLVs and BEIs. (ACGIH)
JIS Z 7252 : 2019
JIS Z 7253 : 20192022 Recommendation on TLVs (JSOH)
Notification No. 0111-1 (January 11, 2022), Chemical Hazards Control Division, Industrial
Safety and Health Department, Labour Standards Bureau, MHLW in Japan
Supplier's data/information
Chemicals safety data management system "GHS Assistant" Version 4.25 (https://www.asahi-ghs.com/)
NITE Chemical Risk Information Platform "NITE-CHRIP"(https://www.nite.go.jp/en/chem/chrip/chrip_search/systemTop)
GHS Classification Guidance for Enterprises 2019 Revised Edition (Ver. 2.0) （Mar. 2020, METI)
Abbreviations and acronyms
SDS (Safety Data Sheet)
LD50 (Lethal Dose, 50％)
LC50 (Lethal Concentration, 50％)
IARC (International Agency for Research on Cancer)
ACGIH (American Conference of Governmental Industrial Hygienists)
EPA (US Environmental Protection Agency)
NTP (US National Toxicology Program)
JSOH (Japan Society for Occupational Health)EU (European Union)
EC50 (Effective Concentration, 50％)
NOEC (No Observed Effect Concentration)
BOD (Biochemical Oxygen Demand)
COD (Chemical Oxygen Demand)BCF (Bioconcentration Factor)anh (anhydride)
General Disclaimer
This data sheet was created based on the information we currently have and may be revised
according to new information. In addition, the precautions apply only to normal handling,
and in the case of special handling, please make adequate countermeasure to maintain yoursafety.
The data given here is based on current knowledge and experience. The purpose of this
Safety Data Sheet is to describe the products in terms of their safety requirements. The
data does not signify any warranty with regard to the products' properties.
The GHS classification data given here is based on current Japan official data (NITEpublished in 2022).