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Product Name : Uricase (UAO-201)

First issue : Oct. 1. 2014
Revised: May. 31. 2022
SDS No 937F

Safety Data Sheet
1 Chemical Product and Company Identification
Identification of the productProduct CodeSupplier
NameAddress
Department
Phone
Fax

Recommended use and restrictions on use

UricaseUAO-201TOYOBO CO.,LTD.
Osaka Umeda Twin Towers South,
1-13-1 Umeda Kita-ku, Osaka 530-0001, Japan
Biotechnology Overseas Sales and Marketing Department+81-6-6348-3846+81-6-6348-3833
diagnostic product2 Hazard Identification
Important hazards
Adverse effects on human healthGHS classification
Physical hazards
Health hazards
Acute toxicity : Oral
Acute toxicity : Dermal
Acute toxicity : Inhalation (Gas,Vapour)
Acute toxicity : Inhalation (Dust,Mist)
Skin corrosion/irritation
Serious eye damage/Eye irritation
Sensitization : Respiratory
Sensitization : Skin
Germ cell mutagenicity
Carcinogenicity
Toxic to reproduction
Specific target organ toxicity(Single exposure)Specific target organ toxicity(Repeatedexposure)Harmful if Boric acid or Sodium tetraborate areswallowed.
Lethal dose (Boric acid ) : Adult 10g , Child 5g

Category 5
Category 2
Category 2ACategory 2
Category 1(nervous system, gastrointestinal tract,respiratory organ, kidneys)
Category 1(nervous system, gastrointestinal tract,respiratory organ, kidneys)
Category 2(testis)

Aspiration hazard
Environmental hazards
Acute hazards to the aquatic environmentLong-term hazards to the aquatic environment Hazard to the ozone layer-:Classification not possible
GHS Label Elements
Symbol/Pictograms

Signal word
Hazard statements

DangerMay be harmful if swallowed.
May cause skin irritation.
May cause serious eye irritation.
May damage fertility or the unborn child.
Cause damage to nervous system, gastrointestinal tract,respiratory organ and kidneys.

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Product Name : Uricase (UAO-201)

First issue : Oct. 1. 2014
Revised: May. 31. 2022
SDS No 937F

Safety Data Sheet
Cause damage to nervous system, gastrointestinal tract,
respiratory organ, kidneys through prolonged or repeatedexposure.
May cause damage to testis through prolonged or repeatedexposure.
Precautionary statements

Prevention Obtain special instructions before use.
Do not handle until all safety precautions have been readand understood.
Wear protective gloves/protective clothing/eye
protection/face protection.
Do not breathe dust/fume.
Do not eat, drink or smoke when using this product.
Wash hands thoroughly after handling.
Response Get medical advice/attentions if you feel unwell.
If ON SKIN: Wash with plenty of water/soap. Take off
contaminated clothing and wash it before use.
If skin irritation occurs: Get medical advice/attention.
If in eye: Rinse cautiously with water for several
minutes. Remove contact lenses, if present and easy todo. Continue rinsing. If eye irritation persists, getmedical advise/attention.
If exposed or concerned: Get medical attention/advice.
Storage Store locked up.
Store in a well-ventilated place. Keep container tightlyclosed.
Disposal Dispose of contents/container in accordance withlocal/regional/national/international/regulation.

Important symptoms (Boric acid) Symptoms of vomit,diarrhea, collapse,erythema may appear
after 2-3 hours later and die after 3-5 days later fromingestion.

3

Composition/Information on Ingredients
Substance/Mixture
Chemical Nature
Chemical specificity
Concentration or concentration range
Main components
UricaseBoric acid
Sodium tetraborate decaydrate
Ingredients Contributing to the Hazard
Common Chemical nameChemical formulaCAS#
Common Chemical nameChemical formula
CAS#
Boron content of this product4Mixture
UricaseFreeze and drying powder including enzyme
ca. 31 %(W/W)
CAS ＃9002-12-4
10043-35-3
1303-96-4
Boric acid
H3BO3
10043-35-3
Sodium tetraborate decahydrate
Na2B4O7・10H2O
1303-96-4
ca. 15 %(W/W)

First Aid Measures
Inhalation
Skin Contact

Remove to fresh air. Consult a physician whenunpleasantness occurs.
Wash off with plenty of water. Consult a physician wheninflammation on the skin occurs.

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Product Name : Uricase (UAO-201)

First issue : Oct. 1. 2014
Revised: May. 31. 2022
SDS No 937F

Safety Data Sheet
Eye Contact

Rinse cautiously with water for several minutes. Remove
contact lenses,if present and easy to do.Continue
rinsing.

Ingestion

Rinse mouth. Swill plentiful amount of water or milk for
immediate vomiting. Consult a physician.
Inhalation: cough, pant, pharyngeal pain, nosebleed.
Skin:
dry skin.
Eye: redness, pain
Ingestion: stomachache,derangement, diarrhea, headache, nausea, vomit,Protector should wear appropriate wear.
Need a rest and medical follow up.

Most important symptoms/effects, acute anddelayed.

Protection for first-aides
Special notes for doctors

5 Fire Fighting Measures
Specific extinguishing methods
Precautions for fire-fighters

Water spray,dry chemical powder,or carbon dioxide etc.
Firefighter should work from the windward side.

6 Accidental Release Measures
Personal Precautions, protective equipment
and emergency procedure.
Environmental Precautions
Methods and materials for containment andcleaning up.

Wear protective gear to avoid eye/skin contact andinhalation. Do not work at leeward.
High concentrated waste fluid should not be directly
discharged into rivers.
Take up under vacuum using dust collecting filter, wash
residual spill with copious amounts of water. Usecloth, paper or anything similar to soak up thesolution leaking out of the container.
(Waste water should be treatedwith activated sludge or adsorbed with activated carbon

7 Handling and Storage
Handling
Technical Measures
Precautions
Safe Handling Advice

Wear protective gear to avoid eye/skin contact andinhalation.
Do not drop the container to prevent the content poppingout.
Obtain special instructions before use.
Do not handle until alll safety precautions have beenread and understood.
Wear protective gear, avoiding contact on eye, skin andcloths.
Ventilate a room to keep air under permissible exposure
limit.
Do not eat,drink or smoke when using this product.
Wash hands thoroughly after handling.

StorageTechnical Measures
Incompatible substances and mixtures
Storage Conditions
Packaging Materials

Keep sealed container in freezer.
None specified.
Store under -20℃ to avoid deactivating.
Use the initial container of the product.

8 Exposure Controls/Personal Protection
Engineering controls
Occupational exposure limit,biological limit
Personal Protective Equipment
Respiratory Protection

Provide shower and eye washing apparatus nearby.
TLV: TWA 2mg/m3, STEL 6mg/m3
Protecting mask

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Product Name : Uricase (UAO-201)

First issue : Oct. 1. 2014
Revised: May. 31. 2022
SDS No 937F

Safety Data Sheet
Hand Protection
Eye Protection
Skin and Body Protection

Protecting gloves
Safety goggles
Long sleeve working wear

9 Physical and Chemical Properties
Physical State, form and colorOdour
pH
Flash Point
Explosiveness
Density
Solubility

Powder / WhiteNo odour
ca. pH 8.5 (1% W/V)
No information available.
No information available.
No information available.
Freely soluble in water.

10 Stability and Reactivity
Stable at temperatures below -20℃.When left for long at
Possible hazard reactions at room temperature,proteins might be degraded, which does
not cause any hazardous reaction.
specific condition
StabilityConditions to avoid
Materials to avoid
Hazardous Decomposition Products

Prolonged storage under higher temperature than room
temperature and high humidity.
Oxidizing agent
No information available.

11 Toxicological Information(1) Boric acid
Acute Toxicity (Oral)
Skin corrosion/irritation
Serious eye damage/irritation
Sensitization
Germ cell mutagenicity

Rat LD50 2660mg/kg
Moderate irritation (guinea pig, 24hr, 72hr)
Rubefaction /Pain
No data available
Absence of data on multi-generation mutagenicity tests
and germ cell mutagenicity tests in vivo, and negative
data on somatic cell mutagenicity tests in vivo
(micronucleus tests)

Carcinogenicity
Toxic to reproduction

ACGIH (2005): Category A4Adverse effects on reproduction of parental animals anddevelopment of pups at doses producing no parental
toxicity.

Specific target organ toxicity(Single exposure)

Human:Gastrointestinal tract effects such as nausea,vomiting, abdominal pain and diarrhea, and central nerve
effects such as lethargy, headaches, fever, increased
irritability and muscle convulsion.
Irritation of the upper respiratory tract.
Animal:cyanosis, tetany, spasm and shock-like symptoms at
dosing levels within the guidance value ranges for
Category 1.

Specific target organ toxicity(Repeated exposure)

Human:oliguresis, anuria, and nephropathy including renal
tubular necrosis.

(2) Sodium tetraborate
Acute Toxicity (Oral)

LD50

Acute Toxicity (Dermal)
Skin corrosion/irritation
Serious eye damage/irritation
Toxic to reproduction

4450mg/kg(Category 5)(EHC204)
3493mg/kg,4500mg/kg,4980mg/kg,5660mg/kg,6080mg/kg(ECETOC TR63) 6000 /k

LD50 > 10000mg/kg (HSDB)(Category 4)
May cause dermatitis (Category 2)
May cause strong eye irritation (Category 2A)
Affect spermatogenesis (Category 2). May damage fertilityor the unborn child.

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Product Name : Uricase (UAO-201)

First issue : Oct. 1. 2014
Revised: May. 31. 2022
SDS No 937F

Safety Data Sheet
Specific target organ toxicity(Single exposure)This product causes damage to the nervous system,
respiratory organ, kidneys. (Category 1)

Specific target organ toxicity(Repeated exposure)This product causes damage to the nervous system,
respiratory organ, kidneys and testis, through prolonged
or repeated exposure. (Category 2)

Aspiration hazard

Not classification

12 Ecological Information
Acute hazards to the aquatic environment
Persistence /Degradability

Polyethylene Glycol-p-octylphenyl Ether (Triton X-100)
LC50/96hr = 3mg/L (bluegill)
This product is biodegradable and does not remain on theenvironment for long.
22% by BOD (National Institute ofTechnology and Evaluation, Japan)

13 Disposal Considerations
Residues
A pollution container and packing

Dispose of in accordance with all applicable local andnational laws and regulations.
Wash with copious amounts of water and waste conforming
to local regulations depending on the type of thematerial.

14 Transport Information
International regulations
IMO information
IATA information
Domestic regulations
Rail and road transportation information
Marine transportation information
Aviation transportation information
Specific precautions transport measures andconditions

Not applicableNot applicableNot applicableNot applicableNot applicable
Avoid direct sunshine and check the container and loading
to prevent leakage or turnover,fall and damage.Transport
in accordance with regulations.Do not load with foods andfeed. Keep at temperatures below -20℃.

15 Regulatory Information
Registration, Evaluation, Authorization and Restrictionof Chemicals (EU)Common Chemical nameChemical formulaCAS#
Common Chemical nameChemical formula
CAS#
Boron content of this productFollowing components of this product are included in SVHC
(Candidate list of authorization).
Boric acid
H3BO310043-35-3
Sodium tetraborate
Na2B4O7・10H2O
1303-96-4
ca. 11 %(W/W)

16 Other Information
Notice

The information shall not be taken as being all inclusive
and is to be used only a guide.All materials and mixtures
may be present unknown hazards and should be used withcaution.The SDS is subject to revision as new information
becomes available.The information in this SDS,to the bestof our knowledge, is accurate and correct. However,TOYOBO
makes no warranty and assumes no liability whatsoever inconnection with any use of this information.