August 2, 2021

Seikagaku Announces the Launch of HyLink®, an Intra-Articular SingleInjection Viscosupplement for the Treatment of Knee Osteoarthritis inTaiwan
Seikagaku Corporation (Chiyoda-ku, Tokyo, Japan; “Seikagaku”) announced today the launch ofHyLink®, an intra-articular single-injection viscosupplement for the treatment of knee osteoarthritis in
Taiwan, through TCM Biotech International Corp. (New Taipei City, Taiwan; “TCM”).
HyLink® is an intra-articular single-injection viscosupplement for the treatment of knee osteoarthritis
whose main ingredient is a cross-linked hyaluronate hydrogel made using Seikagaku’s unique crosslinking technology. Since the highly viscoelastic hyaluronate hydrogel remains in the knee joint cavity fora long period of time, HyLink® is expected a long-lasting improvement of symptoms by an administrationof only 3 mL .
TCM is a pharmaceutical company with a nationwide sales network in Taiwan that has strengths in
the fields of orthopedics and rehabilitation. TCM exclusively distributes in Taiwan ARTZDispo®*1 andArtzfors®*2, intra-articular multiple-injection viscosupplements manufactured by Seikagaku. Theseproducts hold a high share in the Taiwanese market for hyaluronic acid treatments, which is expected toexpand as the elderly population grows, and TCM will aim to further strengthen its presence in themarket by introducing HyLink® in addition to ARTZDispo® and Artzfors®.
Seikagaku will continue to support TCM’s sales promotion activities through the provision of academic
information in its capacity as manufacturer, and Seikagaku and TCM together will contribute toimproving the quality of life of patients.
*1 ARTZDispo®: A medical device indicated for knee osteoarthritis and rotator cuff lesions without completetears*2 Artzfors®: A medical device indicated for rotator cuff lesions without complete tears

HyLink®

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About Knee Osteoarthritis
Knee osteoarthritis is a disease in which joint tissue degenerates and inflammation and pain occur due
to the wearing of articular cartilage. Since bones come into direct contact with one another as thecondition and cartilage wear progress, intense pain occurs when the knee joint is moved. The
occurrence of knee osteoarthritis is said to be associated with aging, obesity, external injury, excessive
exercise, genetic predisposition, and other factors.
About Seikagaku Corporation
Seikagaku Corporation is an R&D-oriented pharmaceutical company that focuses on glycoscience as
an area of specialization. Since its foundation in 1947, Seikagaku has continuously focused on thepossibilities of glycoscience and developed original, beneficial pharmaceutical products and medical
devices in the fields of orthopedic disorders and ophthalmic diseases. Under a unique business modelof specializing in R&D and manufacturing without having an in-house pharmaceuticals sales division,
Seikagaku contributes to healthy and fulfilling lives for people around the world by marketing products
globally in collaboration with companies having strengths in particular countries and product areas.
Detailed information is available on the Seikagaku website (https:www.seikagaku.co.jp/english/).
About TCM
TCM is a pharmaceutical company founded in 1998 that has a nationwide sales network in Taiwan. It
has expertise and strengths particularly in the fields of orthopedics and rehabilitation and offers
innovative products. Detailed information is available on the TCM website (http://www.tcmbio.com).

< Cautionary Notes >This press release contains forward-looking statements regarding future management strategies
and performance forecasts. These descriptions are based on judgments derived from informationthat is currently available to Seikagaku and are subject to risk and uncertainty. Actual results anddevelopments may differ significantly from these descriptions due to various factors.
Information about pharmaceutical products or medical devices (including products currently indevelopment) contained in this press release is not intended to constitute an advertisement or medicaladvice.

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