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Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 23.03.2023*Version number 2

Revision: 23.03.2023

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Trade name: R-404A
Article number: R404A STD
1.2 Relevant identified uses of the substance or mixture and uses advised against: Refrigerant
1.3 Details of the supplier of the safety data sheet
Manufacturer/Supplier:
DAIKIN INDUSTRIES, LTD. CHEMICALS DIVISION:OSAKA UMEDA TWIN TOWERS SOUTH, 1-13-1 Umeda, Kita-ku, Osaka-shi, Osaka, 530-0001, Japan
Phone:+81-6-6147-9702 Fax:+81-6-6147-9807
Further information obtainable from: http://www.daikin.com/
1.4 Emergency telephone number:
Japan: +81-6-6349-7521
China: +86-532-8388-9090, +86-21-34151689
South Korea: +82-2-568-1722
Americas: CHEMTREC +1-800-424-9300 (Outside US/Canada: +1-703-527-3887)
Europe: +49-211-179 225-0

SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008

Press. Gas (Liq.) H280 Contains gas under pressure; may explode if heated.
2.2 Label elements
Labelling according to Regulation (EC) No 1272/2008:
The product is classified and labelled according to the CLP regulation.
Signal word: Warning
Precautionary statements:
P410+P403 Protect from sunlight. Store in a well-ventilated place.
*

SECTION 3: Composition/information on ingredients
Information on ingredients:
CAS: 420-46-2 1,1,1-Trifluoroethane
Flam. Gas 1B, H221
Press. Gas (Liq.), H280

51.0-53.0%

CAS: 354-33-6 PentafluoroethanePress. Gas (Liq.), H280

42.0-46.0%

CAS: 811-97-2 1,1,1,2-TetrafluoroethanePress. Gas (Liq.), H280
Additional information: For the wording of the listed hazard phrases refer to section 16.

2.0-6.0%

SECTION 4: First aid measures
4.1 Description of first aid measures
General information: Seek immediate medical advice.
After inhalation:
Take affected persons into fresh air. Keep at rest.
Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult a doctor if symptoms persist.
In case of unconsciousness place patient stably in side position for transportation.
In case of emergency to rescue the victims; be sure to wear supplied-air respirator (SAR) or self-contained breathing
apapratus (SCBA).
(Contd. on page 2)

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Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: R-404A(Contd. of page 1)

If the patient does not breathe or hardly breathes, unbutton clothes, secure the airway for breathing and perform
artificial respiration.
At high levels, cardiac arrhythmia may occur.
After skin contact:
In cases of frost bites, rinse with plenty of water. Do not remove clothing.
Immediately rinse with warm water and soap.
Consult a doctor in case of complaints.
After eye contact:
Rinse opened eye for several minutes under running water.
Consult an ophthalmologist in case of complaints.
After swallowing: Not applicable.
Information for doctor:
Catecholamines such as adrenaline, and other compounds having similar effects, should be reserved for emergencies
and then used only with special caution.
The examining physician should advise workers taking medications containing catecholamines that they may be atincreased risk and should avoid excessive exposure.
4.2 Most important symptoms and effects, both acute and chronic:
Frost bitesHigh concentrations cause asphyxiation. May cause an abnormal heart rhythm and prove suddenly fatal.
4.3 Indication of any immediate medical attention and special treatment needed:
No further relevant information available.

SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing agents:
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
Use fire extinguishing methods suitable for surrounding conditions.
5.2 Special hazards arising from the substance or mixture:
Hydrogen fluoride (HF)
Formation of toxic gases is possible during heating or in case of fire.
Receptacle may explode when heated.
5.3 Advice for firefighters:
Move receptacle to a safe place immediately if possible. If not, spray water on the receptacles and surrounding
equipment to cool.
If receptacle catches fire: cool them with plenty of water.
If possible, close valves of receptacles to shut off the gas supply.
Protective equipment:
Wear self-contained breathing apparatus and protective suit.
Do not inhale explosion gases or combustion gases.

SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures:
Remove persons from danger area.
Wear appropriate protective devices (See Section 8 Exposure Controls/Personal Protection).
Avoid contact with eyes and skin.
Do not inhale the product.
Ensure adequate ventilation before entering the area.
Stay on the windward side.
Keep out unauthorized persons.
6.2 Environmental precautions:
Suppress gases/fumes/haze with water spray.
Must not be emitted into the environment.
6.3 Methods and material for containment and cleaning up: Ensure adequate ventilation.
6.4 Reference to other sections:
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
(Contd. on page 3)

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Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: R-404A(Contd. of page 2)*

SECTION 7: Handling and storage
7.1 Precautions for safe handling:
Waste air is to be released into the atmosphere only via suitable separators.
Danger of ignition/explosion if mixed with flammable gas.
Ensure good ventilation/exhaustion at the workplace.
Handle with care. Avoid jolting, friction and impact.
For heating receptacle, use hot compresses or lukewarm water below 40 .
Do not use heaters.
Stay on the windward side when working outdoors.
Be careful of leakage when attaching/detaching receptacles.
Inhaling large quantities may cause cardiac arrhythmia or asphyxiation or both.
Keep away from naked flame or metal heated over 300 - 400
to prevent thermal decomposition that may form
toxic gases.
Do not handle until all safety precautions have been read and understood.
Information about fire - and explosion protection:
The product is not flammable.
Keep ignition sources away - Do not smoke.
Keep respiratory protective device available.
7.2 Conditions for safe storage, including any incompatibilities:
Storage
Requirements to be met by storerooms and receptacles:
Store in a cool and dry location.
Keep containers tightly sealed.
Information about storage in one common storage facility:
See section 10 for information on incompatible materials.
Further information about storage conditions:Protect from heat and direct sunlight.
Store containers in a well ventilated area.
Store locked up.
7.3 Specific end use(s): No further relevant information available.

SECTION 8: Exposure controls/personal protection
8.1 Control parameters No further information available.
Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be monitored at theworkplace.
Additional information: The lists valid during the making were used as basis.
8.2 Exposure controls
Appropriate engineering controls No further data; see item 7.
Individual protection measures, such as personal protective equipment
General protective and hygienic measures:
Do not smoke.
Wash hands before breaks and at the end of work.
Do not eat or drink while working.
Keep away from tobacco products.
Respiratory protection: Use respiratory protective device with organic gas cartridge.
Hand protection
Protective gloves
To avoid skin problems reduce the wearing of gloves to the required minimum.
Material of gloves:
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality andvaries from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance ofthe glove material can not be calculated in advance and has therefore to be checked prior to the application.
(Contd. on page 4)56.0

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Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: R-404A(Contd. of page 3)

Leather
Eye/face protection
Safety glasses
Body protection: Protective work clothing*SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
General Information
Liquefied gas
Physical state
ColourlessColour:
Ether-like
Odour:
Not determined.
Odour threshold:
Undetermined.
Melting point/freezing point:
Boiling point or initial boiling point and boiling range -46.7 °C
No data.
Flammability
Lower and upper explosion limit
No further information available.
Lower explosive limit:
Not determined.
Upper explosive limit:
Not applicable.
Flash point:
No further information available.
Decomposition temperature:
Not determined.
pHViscosity:
Not determined.
Kinematic viscosity
Not determined.
Dynamic:
Solubility
0.070 g/100g
water at 25 °C:
No further information available.
Partition coefficient n-octanol/water (log value)
1.25 MPa
Vapour pressure at 25 °C:
Density and/or relative density
1.043 g/cm³
Density at 25 °C:
Not determined.
Relative density
3.4 g/cm³ (air=1)
Vapour density
No further information available.
Particle characteristics
9.2 Other information:
Form:
Auto-ignition temperature:
Explosive properties:
Evaporation rate

Liquefied gas
Product is not self-igniting.
Not determined.
Not applicable.

Information with regard to physical hazard classes
Not applicable
Explosives
Not applicable
Flammable gases
Not applicable
Aerosols
Not applicable
Oxidising gases
Gases under pressure
Contains gas under pressure; may explode if heated.
Not applicable
Flammable liquids
Not applicable
Flammable solids
Not applicableSelf-reactive substances and mixtures
Not applicable
Pyrophoric liquids
Not applicable
Pyrophoric solids
Not applicableSelf-heating substances and mixtures
Substances and mixtures, which emit flammable gases
Not applicablein contact with water(Contd. on page 5)56.0

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according to 1907/2006/EC, Article 31
Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: R-404A(Contd. of page 4)

Oxidising liquids
Oxidising solids
Organic peroxides
Corrosive to metals
Desensitised explosives

Not applicableNot applicableNot applicableNot applicableNot applicable

SECTION 10: Stability and reactivity
10.1 Reactivity No further relevant information available.
10.2 Chemical stability
Thermal decomposition / conditions to be avoided: To avoid thermal decomposition do not overheat.
10.3 Possibility of hazardous reactions: No dangerous reactions known under normal conditions of use.
10.4 Conditions to avoid: Keep away from heat, sparks, flame, high temperature.
10.5 Incompatible materials: Alkali or alkaline earth metals - powdered Al, Zn, Mg, etc.
10.6 Hazardous decomposition products: Hydrofluoric acid, carbonyl fluoride

SECTION 11: Toxicological information
11.1 Information on hazard classes as defined in Regulation (EC) No 1272/2008 No futher information available.
Acute toxicity no data
LD/LC50 values relevant for classification: No further information available.
Skin corrosion/irritation: No further information available.
Serious eye damage/irritation:
No further information available.
No further information available.
after inhalation: No further information available.
Respiratory or skin sensitisation: No further information available.
Germ cell mutagenicity: In vitro tests did not show mutagenic effects.
Carcinogenicity: No further information available.
Reproductive toxicity: No further information available.
STOT-single exposure: No further information available.
STOT-repeated exposure: No further information available.
Aspiration hazard: No further information available.
Other information (about experimental toxicology): No further information available.
Subacute to chronic toxicity: No further information available.
11.2 Information on other hazards:
Endocrine disrupting properties:
None of the ingredients is listed.
*SECTION 12: Ecological information
12.1 Toxicity
Aquatic toxicity: No further relevant information available.
12.2 Persistence and degradability: Not easily biodegradable
Other information: The product is slightly biodegradable.
Abiotic degradation:
Air, indirect photo-oxidation
Conditions: sensitizer: OH radicals
Degradation products: Carbon dioxide (CO ) / hydrofluoric acidWater: non-significant hydrolysis
12.3 Bioaccumulative potential:
Due to the distribution coefficient n-octanol/water an accumulation in organisms is not expected.
12.4 Mobility in soil: No further relevant information available.
12.5 Results of PBT and vPvB assessment
PBT: No further relevant information available.
vPvB: No further information available.
12.6 Endocrine disrupting properties For information on endocrine disrupting properties see section 11.
12.7 Other adverse effects:
Ecotoxical effects: no data(Contd. on page 6)56.0

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Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: R-404A(Contd. of page 5)

Additional ecological information:
General notes:
Ozone depletion potential(ODP) : 0(Pentafluoroethane)
Global warming potential(GWP) :0.94

SECTION 13: Disposal considerations
13.1 Waste treatment methods
Recommendation:
Disposal must be made according to official regulations.
Incineration in an adequate incinerator is recommended.
Uncleaned packaging
Recommendation: Disposal must be made according to official regulations.

SECTION 14: Transport information
14.1 UN number or ID number
ADR, IMDG, IATA
14.2 UN proper shipping name:
ADR, IMDG, IATA
14.3 Transport hazard class(es):UN3337REFRIGERANT GAS R 404A

ADR, IMDG, IATA

2.2 Gases.
Class:
14.4 Packing group:
Not applicable
ADR, IMDG, IATA
14.5 Environmental hazards:
No
Marine pollutant:
Not applicable.
14.6 Special precautions for user:
F-C,S-V
EMS Number:A
Stowage Category
14.7 Maritime transport in bulk according to IMO
Not applicable.
instruments
Avoid direct sunlight. Make sure of no damage, corrosion, leaks
Transport/Additional information:on the receptacles.
Take necessary measures for preventing cargo shift.
ADR
120 mlLimited quantities (LQ):
Code: E1
Excepted quantities (EQ)
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 1000 ml
IMDG
120 mlLimited quantities (LQ)
Code: E1
Excepted quantities (EQ)
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 1000 ml
UN 3337 REFRIGERANT GAS R 404A, 2.2
UN "Model Regulation":*SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Labelling according to Regulation (EC) No 1272/2008
The product is classified and labelled according to the CLP regulation.
(Contd. on page 7)56.0

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Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 23.03.2023

Version number 2

Revision: 23.03.2023

Trade name: R-404A(Contd. of page 6)

Hazard pictograms

GHS04
Signal word Warning
Hazard statements
H280 Contains gas under pressure; may explode if heated.
Precautionary statementsP410+P403 Protect from sunlight. Store in a well-ventilated place.
National regulations No further information available.
15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

SECTION 16: Other information
The product is for the industrial use only. We do not guarantee the safety in case the product is used for the otherpurposes. When using the product for health-care application or food/feed application, consult us in advance.
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specificproduct features and shall not establish a legally valid contractual relationship.
Department issuing SDS: EHS Department
Contact: http://www.daikin.com/Abbreviations and acronyms:
ADR: Accord relatif au transport international des marchandises dangereuses par route (European Agreement Concerning the International
Carriage of Dangerous Goods by Road)
IMDG: International Maritime Code for Dangerous Goods
IATA: International Air Transport Association
GHS: Globally Harmonised System of Classification and Labelling of Chemicals
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very Bioaccumulative
Flam. Gas 1B: Flammable gases – Category 1B
Press. Gas (Liq.): Gases under pressure – Liquefied gas* Data compared to the previous version altered.