様式 Form 7（外国人招へい研究者）
2024 年 6 月 20 日
2024/06/20

独立行政法人日本学術振興会理事長 殿
To: President, Japan Society for the Promotion of Science

研究活動報告書
Research Report
１．受入研究者/ Host researcher
受入研究機関・部局・職
Name of Host Institution, Department and Title

受入研究者氏名Host Researcher’s Name

北海道大学・創成研究機構化学反応創成研究拠点・教授
美多 剛

２．外国人招へい研究者/ Fellow
所属研究機関・部局・職
Name of Institution, Department and Title

外国人招へい研究者氏名
Fellow’s Name

パデュー大学・化学科・教授
UYEDA Christopher Hiroki

３．採用期間/ Fellowship Period2024 年

5月7日～

2024 年

6月6日

４．研究課題/ Research Theme
レドックス活性を有する多核金属錯体によるカルベン挿入反応の開発と工業的利用５．研究活動報告/ Research Report（１）研究活動の概要・成果/ Summary of Research Results
Christopher Uyeda 教授は、まず受け入れ研究者である美多の在籍する北海道大学反応創成研究拠点（WPI-ICReDD）に 5/7から滞在し、美多グループとの共同研究の打ち合わせ、および ICReDD の PI および Junior PI との研究ミーティングを実施した。Uyeda 教授は自身が開発したカルベン挿入反応の選択性の逆転現象に非常に強い興味を持っており、ICReDD の計算手法を用いてその課題を解決すべく有意義なディスカッションをすることができた。来年の ICReDD が主催する MANABIYAプログラムで Uyeda 教授の学生を派遣して共同研究を始めることになった。また、大学院生を対象とした英語でのプレゼンテーションセミナーを実施して英語による教育指導も行った。
（２）主な研究発表（雑誌論文、学会、集会、知的財産権等）/ Main Research Publications
招へい研究者の講演会・研究討議の実施
Christopher Uyeda 教授は ICReDD での共同研究の打ち合わせ、およびインターナショナルセミナー（講演会）の後、5/13～6/6 まで、以下の研究者を訪問し、講演会の実施、それぞれの研究機関での有機合成化学研究者との交流、大学院生・若手教員との研究討議を実施し、日米間での共同研究の可能性を検討した。

（注）採用期間終了後 3 ヶ月以内に提出※ (Note) Submit the form within 3 months after the expiration of fellowship.
※ 様式 1 に記載された情報を元に確認しますので、部局名等の名称含め、内容に誤りが無いか必ずご確認ください。

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様式 Form 7（外国人招へい研究者）
訪問機関およびホスト研究者
講演タイトル：「Catalytic Transfer Reactions of Non-stabilized Carbenes」
集会場所：
1. 北海道大学：美多 剛（化学反応創成研究拠点（WPI-ICReDD））
2. 東京大学：金井 求（大学院薬学系研究科）
3. 東京工業大学：山下 誠（大学院理学院）
4. 名古屋大学：石原 一彰（大学院工学研究科）
5. 京都大学：松永 茂樹（大学院理学研究科（吉田キャンパス））
6. 京都大学：中尾 佳亮（大学院工学研究科（桂キャンパス））
7. 大阪大学：平野 康次（大学院工学研究科）
8. 九州大学：大嶋 孝志（大学院薬学研究院）（３）その他/ Remarks
招へい期間内の具体的な実施内容を以下に記す（Uyeda 教授執筆）。

My JSPS fellowship began when I arrived in Sapporo in the evening on Tuesday, May 7, 2024. On Wednesday,
May 8, I met my host for the JSPS program, Prof. Tsuyoshi Mita, and I spent three days at Hokkaido University
where I had many engaging discussions with faculty members at ICReDD and the rest of the chemistry department.
My lab at Purdue University has recently been interested in developing new capabilities in high throughput
experimentation and computational prediction. I had an opportunity to tour the ICReDD facility that houses a newautomation platform for reaction optimization. I also talked with several faculty members about the newcomputational methods developed by Prof. Satoshi Maeda to predict reaction pathways and to use virtual methods
to evaluate ligand effects. We are planning to start some new collaborations and research directions based on these
discussions, and I hope to send a student to ICReDD next year as part of the MANABIYA program. On May 10, I
presented a lecture on carbene and bimetallic chemistry, which was followed by a lively discussion. During my visit
to Hokkaido, I also had an opportunity to hear English lectures from several graduate students and to provide
feedback on the presentation.
On Sunday, May 12, I flew to Tokyo where I spent the next week discussing chemistry with faculty members at
the University of Tokyo and the Tokyo Institute of Technology. At the University of Tokyo, my host was Prof.
Motomu Kanai, and I had a very fruitful meeting with him as well as several other faculty members, including Prof.
Yoshiaki Nishibayashi, who is an expert on bimetallic chemistry. At the Tokyo Institute of Technology, my host wasProf. Makoto Yamashita, and I had several meetings with members of his lab to discuss their recent work on maingroup and transition metal chemistry. I met with Prof. Tetsuro Murahashi, who discovered some of the metal
precursors that our lab has used to prepare dipalladium complexes. I presented a seminar at the University of Tokyo
on May 13 and at the Tokyo Institute of Technology on May 16.
On Saturday, May 18, I took the train to Nagoya and visited Nagoya University on May 20. My host was Prof.
Kazuaki Ishihara, and I spent the day meeting with faculty members and giving a lecture. I then travelled to Kyoto
where I visited and presented seminars at both the Yoshida and Katsura campuses of Kyoto University on May 22
and 23. I had many fruitful scientific interactions during the two-day period. Our lab has been developing cobalt andnickel-catalyzed carbene transfer reactions, and I was able to compare our findings with Prof. Takashi Kurogi whohad studied related reactions using chromium. During this visit, I also had opportunities to reconnect with former
members of Purdue’s chemistry department, Prof. Yuichiro Watanabe and Dr. Kohei Sasakura, who are now
academic and industrial scientists in Japan.
After spending the weekend in Kyoto, I then travelled to Osaka University. Osaka University’s chemistry
department has many groups studying organometallic chemistry, and visiting the department provided many
wonderful opportunities to have in-depth discussions. My host was Prof. Koji Hirano, and we discussed his group’sdevelopment of new chemistry to generate compounds containing fluorinated functional groups. Another highlightof my visit was a discussion with Prof. Hayato Tsurugi. He developed a new class of disilylated heterocycle（注）採用期間終了後 3 ヶ月以内に提出※ (Note) Submit the form within 3 months after the expiration of fellowship.
※ 様式 1 に記載された情報を元に確認しますので、部局名等の名称含め、内容に誤りが無いか必ずご確認ください。

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様式 Form 7（外国人招へい研究者）

reductants, and we plan to test some of his reagents in our carbene transfer chemistry. I presented a lecture at Osaka
University on May 30.
I travelled to Fukuoka on Friday, May 31 and visited Kyushu University on Monday, June 3. I was hosted by Prof.
Ohshima and had many meetings throughout the day with faculty members before my seminar in the afternoon.
Finally, on June 4, I had a virtual meeting with Prof. Tsuyoshi Mita to discuss a possible collaboration to use
computational predictions for one of our cycloaddition reactions. We proposed having one of my senior graduate
students apply to the MANABIYA program when the applications open next year. I left Japan on June 6 and am
making a stop in Taiwan before returning to the US.
I want to sincerely thank the JSPS program for supporting my time in Japan and to my hosts, Prof. Tsuyoshi Mitaand members of Hokkaido University, for organizing my visit. The JSPS fellowship provided me with a unique
opportunity to exchange new ideas, build connections with Japanese researchers, and initiate new collaborations. I
hope that it was also mutually beneficial for Japanese students to have an opportunity to develop theircommunication skills through discussions and presentations in English. I look forward to future opportunities to hostJapanese scientists in the US. I will gratefully acknowledge support from JSPS in all future publications that result
from scientific exchanges during this fellowship.
Uyeda 教授の講演会、および英語プレゼンテーションセミナーの写真を示す。

（注）採用期間終了後 3 ヶ月以内に提出※ (Note) Submit the form within 3 months after the expiration of fellowship.
※ 様式 1 に記載された情報を元に確認しますので、部局名等の名称含め、内容に誤りが無いか必ずご確認ください。

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