Program

September 9 (Monday)
9:00 ～ 9:10

Opening Remark

The 26th Annual Meeting of the Japanese Society of Immunotoxicology
President: Minoru SatohThe 76th Meeting of Allergy and Immunotoxicology study group of Japan Society for Occupational Health
Coordinator: Takahiko Yoshida

9:10 ～ 9:55 Oral Presentations ＜O-01 ～ O-03＞
Chairperson : Yasuo Yoshioka (Research Institute for Microbial Diseases, Osaka University)
O-01

Cholera toxin B subunit can induce production of pro-inflammtory cytokine IL-1β.
○ Izumi Sasaki1, Takashi Orimo1, Hiroaki Hemmi2, Keima Tsuchiya1, Sho-ichi Inoue1, Naomitsu
Kumagai1, Koichi Furukawa3, Tsuneyasu Kaisho11
1

Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Japan

2

Faculty of Veterinary Medicine, Okayama University of Science, Japan3

Department of Lifelong Sports and Health Sciences, Chubu University College of Life and HealthSciences, Japan
O-02

Investigation of the onset mechanism of HLA-mediated drug toxicities using
keratinocytes○Shigeki Aoki, Yushiro Yamada, Sota Fujimori, Takeshi Susukida, Tomohiro Shirayanagi,Saki Kuwahara, Kousei Ito
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan

O-03

TNF-α-stimulated macrophages undergo necroptosis-like death and secret 14-3-3η
○Gulzhan Trimova,1 Kaoru Yamagata,1 Shigeru Iwata,1 Tong Zhang,1 Fumi Uemura,1 Minoru Satoh,2Michelle Zaharik,3 Norma Biln,3 Shintaro Hirata,4 Shingo Nakayamada,1 Yoshiya Tanaka1
1The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan,

2

Department of Clinical Nursing, School of Health Sciences, University of Occupational andEnvironmental Health, Japan,

3Augurex Life Sciences Corp, North Vancouver, BC, Canada

4

Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan

9:55 ～ 11:15 Students and Young Scientists Session ＜Y-01 ～ Y-13＞
Chairperson : Etsushi Kuroda （Hyogo College of Medicine）
Eiko Koike(National Institute for Environmental Studies)
Y-01

Comparison of adjuvant mechanisms of short and medium chain triacylglycerols in an
FITC-induced contact hypersensitivity.
○Akimasa Orii, Kohta Kurohane, Masato Tsutsumi, Kota Sekiguchi, Yasuyuki Imai
Lab. Microbiology and Immunology, School of Pharmaceutical Sciences, University ofShizuoka

Y-02

Short term oral exposure to inorganic arsenic exacerbates inflammatory and pruritic
responses in a mouse model of contact allergic dermatitis○Yuri Ogata 1, Momoka Suzuki1, Naoki Iwasita1,2, Keigo Kurata3, Tomoki Fukuyama1

Y-03

1

Azabu University Faculty of Veterinary Medicine, Pharmacology Laboratory

2

Bioalchemis

3

ITEA Inc. Institute of Tokyo Environmental Allergy

The importance of dose metrics in the forecasting onset risk rate of immediate- typehypersensitivity.
○Kyosuke Yokozeki, Takuo Yuki, Akira Ogasawara, Asuka Katagiri, Yutaka Takahashi

Hitoshi SakaguchiSafety Science Research Laboratories, Kao Corporation, Tochigi, Japan
Y-04

Responses to oral administration of estrogen receptor agonists PPTand DPN in a mouse model of imiquimod-induced psoriasis-like dermatitis○Rena Iwano1, Naoki Iwasita1,2, Tomoki Fukuyama1

Y-05

1

Azabu University Faculty of Veterinary Medicine, Pharmacology Laboratory

2

Bioalchemis

Oral administration of Bisphenol A exacerbates the development of allergic response inan ovalbumin-induced mouse model of food allergy.
○Takanori Oomoto, Tomoki Fukuyama,
Azabu University Faculty of Veterinary Medicine, Pharmacology Laboratory

Y-06

Development of the skin sensitization test for proteins using differentiated THP-1 cells○Yumi Miura, Yuka Sawada, Hanae Kobayashi, Hiroshi Itagaki, Kazutoshi Iijima
Yokohama National University

Y-07

Immunostimulatory effects of biopharmaceuticals associatedwith injection site reactions on THP-1 cells○Eri Hamamura1, Tetsuo Aida2, Yoshimi Tsuchiya1, Kazuhiko Mori1

Y-08

1

Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.

2

Quantitative Clinical Pharmacology & Translational Sciences, Daiichi Sankyo, Inc.

Ursolic acid induced anti-tumor effect and mitochondrial disorder on
adult T cell leukemia cells○Mengyue Shen, Kentaro Morita, Yusuke Sennari, Tamotsu Kanazawa, Yasuhiro Yoshida
Department of Immunology and Parasitology, School of Medicine, University of Occupational andEnvironmental Health, Japan

Y-09

Immunomodulation by valproic acid under cancerous condition.
○Zhiqi Xie1, Tamami Ikegami1, Yukio Ago2, 3, Naoki Okada1, Masashi Tachibana1, 3
1 Proj. Vaccine Immune Reg., Grad. Sch. Pharm., Osaka Univ.
2 Lab. Biopharm., Grad. Sch. Pharm., Osaka Univ.
3 MEIC, Osaka Univ.

Y-10Antihistamines possibly induce colorectal cancer as adverse events○Yuta Masuda, Kiyoka Matsumoto, Rei Matsumoto, Keijo Fukushima, Hiromichi Fujino
Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate
School of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Y-11

Role of methionine in human B cell differentiation and the relevance to pathologicalprocesses of SLE○Mingzeng Zhang, Shigeru Iwata, Maiko Hajime, Naoaki Ohkubo, Yasuyuki Todoroki,Hiroko Miyata, Jie Fan, Shingo Nakayamada, Kaoru Yamagata and Yoshiya TanakaThe First Department of Internal Medicine, School of Medicine,
University of Occupational &Environmental Health, Japan, Kitakyushu, Japan

Y-12

Examination of dendritic cell activation and immunological function by Lactoferrin.
○Daisuke Hanakita1, Kenjiro Nagaoka1,Tatsuo Ito1, Keiki Ogino1 2, Hideyuki Kanda1
1

Department of Public Health, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences,

Okayama University.
2

Department of Environmental Medicine, Kochi Medical School.

Y-13

Impact of size and surface modification on lung toxicity
by intratracheal instillation of amorphous silica.
○Masahide Inoue1, Koji Sakamoto1, Atsushi Suzuki1, Yoshio Nakahara1, Naozumi Hashimoto1,
Yoshinori Hasegawa1 and Makoto Sawada2
1

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan.

2

Research Institute of Environmental Medicine, Nagoya University

11:15 ～ 12:05 Poster Discussion Session １ ＜Y-01 ～ Y-13、P-1 〜 P-18＞(Posters for Young Scientists Session <Y-01〜Y-13> are also included in this session）
P-01

Assessment of surfactant protein D as biomarkers for evaluating pulmonary toxicity ofnanomaterials.
○Taisuke Tomonaga, Hiroto Izumi, Yukiko Yoshiura, Chinatsu Nishida, Takashi Marui,Toshihiko Myojo, Takako Oyabu, Takami Okada, Yasuo Morimoto.
University of Occupational and Environmental Health, Japan,
Institute of Industrial and Ecological Sciences.

P-02

Effect of IL-15 addition on function of CD8+ lymphocytes exposed to asbestos
during MLR○Naoko Kumagai-Takei, Yasumitsu Nishimura, Suni Lee, Kei Yoshitome, Takemi Otsuki
Department of Hygiene, Kawasaki Medical School

P-03

Role of Nephronectin in Pathophysiology in Silicosis○Suni Lee 1 , Machiko Honda 2 , Shoko Yamamoto 1 , Naoko Kumagai-Takei 1 , Kei Yoshitome 1 ,Yasumitsu Nishimura 1 , Shigeyuki Kon 2, Takemi Otsuki 1

P-04

1

Department of Hygiene, Kawasaki Medical School2

Department of Pharmacy and Pharmaceutical Sciences, Fukuyama University

Activation of aryl hydrocarbon receptor by benzo(a)pyrene induces increase in theexpression of IL-33 and infiltration of eosinophils in a mouse model of allergic airway
inflammation○Hitoshi Tajima1, Risako Tajiki-Nishino1, Yuko Watanabe1, Keigo Kurata2, Tomoki Fukuyama1,3
1Institute of Environmental Toxicology

2Institute of Tokyo Environmental Allergy, ITEA Inc.

3

Azabu University Faculty of Veterinary Medicine, Pharmcology Laboratory

P-05

Changes in peripheral blood and splenic lymphocytes in rats exposed to folic aciddeficiency and excess○Emi Makinoi1, Tomomi Murai1, Koichi Hayshi1, Aya Koyama1, Naofumi Takahashi1,Toshinori Yoshida2, Ryoichi Ohtsuka1

P-06

1

The Institute of Environmental Toxicology

2

Tokyo University of Agriculture and Technology, Laboratory of Veterinary Pathology

Comparison of endocytosis between DMSO or ATRA differentiated HL-60 derived
neutrophils○Duo Wang, Kentaro Morita, Yusuke Sennari, Tamotsu Kanazawa, Yasuhiro Yoshida
Department of Immunology and Parasitology, School of Medicine, University of Occupational andEnvironmental Health, Japan

P-07

Effect of co-treatment with Cucurbitacin D and API on cell proliferation in Blastic
plasmacytoid dendritic cell neoplasm (BPDCN)-derived CAL-1 cells.
〇Yusuke Sennari, Kentaro Morita, Tamotsu Kanazawa, Yasuhiro Yoshida
Department of Immunology and Parasitology, School of Medicine, University of Occupational andEnvironmental Health, Japan

P-08

In vitro toxicological support to establish specification limit for anti-CD3monospecific impurity in a bispecific T cell engager drug, ERY974○Asako Harada1, Akifumi Shioda1, Tatsuya Ikuno1, Yoshika Iwata1, Hirotake Shiraiwa1,Tetsuya Wakabayashi1, Yuji Sano1, Masayuki Mishima2

P-09

1

Research Division, Chugai Pharmaceutical Co., Ltd.

2

Translational Research Division, Chugai Pharmaceutical Co., Ltd.

STAT1 acts as a negative regulator of IκB-ζ gene transcription.
○Ryuta Muromoto, Ami Sato, Tadashi Matsuda
Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido UniversityP-10

Fbw7 contributes to regulation of T-cell development via targeting GATA3.
○Kyoko Kitagawa1, 2, Mayumi Tsuji1, Masatoshi Kitagawa2
1

University of Occupational and Environmental Health, Japan2

Hamamatsu University School of Medicine, Japan

P-11

Asian sand dust delays the onset of cyclophosphamide-induced type 1 diabetes inNOD mice
○Kentaro Morita1, Duo Wang1, Ryoko Baba2, Hiroyuki Morimoto2, Tamotsu Kanazawa1,Yasuhiro Yoshida11Department of Immunology and Parasitology, School of Medicine, University of Occupational andEnvironmental Health, Japan2

Department of Anatomy (II), School of Medicine, University of Occupational and Environmental Health,

Japan
P-12

Development of safety and efficacy profiling system for vaccine and adjuvant using
gene expression pattern○Eita Sasaki1, Hideki Asanuma2, Haruka Momose1, Keiko Furuhata1, Takuo Mizukami1,Isao Hamaguchi1
1

Department of Safety Research on Blood and Biological Products, National Institute of Infectious

Diseases, Japan2

P-13

Influenza Virus Research Center, National Institute of Infectious Diseases, Japan

Impact of oral exposure to tris(2-butoxyethyl) phosphate on allergic asthma in mice.
○Rie Yanagisawa1, Eiko Koike1, Tin-Tin Win-Shwe1, Hirohisa Takano2P-14

1National Institute for Environmental Studies

2

Kyoto University

Effects of oral exposure to tris(2-butoxyethyl) phosphate on immune cells in a mousemodel of allergic asthma.
○Eiko Koike1, Rie Yanagisawa1, Tin Tin Win Shwe1, Hirohisa Takano2

P-15

1

National Institute for Environmental Studies

2

Kyoto University

Relationship between serum TARC levels in children and allergic diseases○Reiko Teshima1, Takahiko Yoshida2

P-16

1

Faculty of Veterinary Medicine, Okayama University of Sciences

2

Asahikawa Medical University

Progress of HLA marker analysis on severe advers drug reactions.
○Yoshiro Saito1, Ryosuke Nakamura1, Takuya Imatoh1, Noriaki Arakawa1, Eri Tsukagoshi1,JSAR Research Group2, Kimie Sai1
1

National Institute of Health Sciences, Japan

2

JSAR Research GroupP-17

The association between whole blood concentrations of heavy metals in pregnant
women and premature births: The Japan Environment and Children's Study (JECS)○Mayumi Tsuji, Rie Tanaka, Toshihiro Kawamoto
University of Occupational and Environmental Health, Japan

P-18

Self concept in the immunotoxicological area including pediatric & pediatric surgical
medical supports○Toshiko Sawaguchi1, 21

Tokyo University Social Welfare, ２Graduate School of Tsukuba University

12:05 ～ 12:15

Break

12:15 ～ 12:55

Luncheon Seminar 1 （Japan EMF Information Center）

LS-01

Health risk assessment of EMF and risk perception of EMF in general public○Chiyoji OHKUBOJapan EMF Information Center

12:55 ～ 13:00

Break

13:00 ～ 13:45

General Assembly

13:50 ～ 14:40 Educational Lecture 1
Chairperson: Yasuo Morimoto (University of Occupational and Environmental Health, Japan)
EL-01

Environmental factors and respiratory diseases〇Kazuhiro Yatera
Department of Respiratory Medicine, School of Medicine, University of Occupational andEnvironmental Health, Japan14:50 ～ 16:50
Chairperson :S-01

Symposium“Inflammation and pathophysiology from the viewpointof immunotoxicology”
Yoshiro Saito (National Institute of Health Sciences)
Yasuhiro Yoshida (University of Occupational and Environmental Health, Japan)

Particulate matter-induced modulation of immune responses○Yoshida Y, Morita K.
Department of Immunology and Parasitology, School of Medicine, University of Occupational andEnvironmental Health, Japan

S-02

Rat-specific pulmonary responses induced by phagocytosis of overloaded chemicals
by macrophage○Yasuo Morimoto1, Taisuke Tomonaga1, Hiroto Izumi1,Chinatsu Nishida21

Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University ofOccupational and Environmental Health, Japan2

Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental

Health, Japan
S-03

Asbestos exposure and immune functions, biomarkers based on immunological analyses
for malignant mesothelioma○Yasumitsu Nishimura, Takemi Otsuki
Department of Hygiene, Kawasaki Medical School

S-04

Glutaminolysis and mitochondrial functions in plasmablast differentiation and its
relevance to the pathogenesis of autoimmune diseases○Maiko Hajime1, Shigeru Iwata1, Mingzeng Zhang1, Shingo Nakayamada1, Kazuo Yamamoto2,Yosuke Okada1 and Yoshiya Tanaka1
1

Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University ofOccupational and Environmental Health, Japan
2

Biomedical Research Support Center, Nagasaki University School of Medicine

16:50 ～ 17:00

Break

17:00 ～ 18:00 Special Lecture
Chairperson : Minoru Satoh (University of Occupational and Environmental Health, Japan)
SL-01

Immunotoxicology of inhaled nanoparticles and the implications for lung disease susceptibility○James C. Bonner, Ph.D.
Professor, Toxicology Program, Department of Biological Sciences, North Carolina State University

18:30 ～ 20:30

Banquet and Award Ceremony for Students and Young Scientists(JR Kyushu Station Hotel Kokura 5F)

September 10 (Tuesday)
8:50 ～ 10:20 Oral Presentations ＜O-04 ～ O-09＞
Chairperson : Yasumitsu Nishimura（Department of Hygiene, Kawasaki Medical School）
Katunori Yamaura
O-04（Keio University）

The mechanism of thymus atrophy in zinc deficiency and effects of IL-4
injection or zinc supplementation〇Kido Takamasa, Yoshii Hinano, Yoshioka Wataru, Yanagisawa Hiroyuki
Department of Public Health and Environmental Medicine,
The Jikei University School of Medicine

O-05

Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell
activation assay exhibiting phenotypes and morphological characteristics of humanmast cells.
○Tatsuya Ikuno, Shunsuke Ito, Tomoaki Inoue
Research Division, Chugai Pharmaceutical Co., Ltd.

O-06

Factors influencing the immunogenicity of therapeutic proteins.
○Chiyomi Kubo, Shunsuke Ito, Nobuo Sekiguchi, Tatsuya Ikuno, Mariko Yano, Masayuki Mishima,
Mitsuyasu Tabo, Tomoaki Inoue, Shuichi Chiba
Chugai Pharmaceutical Co., Ltd.

O-07

Analysis of bronchoalveolar lavage fluid in patients with drug-induced pneumonia
caused by immune checkpoint inhibitor○Masahiro Tahara, Kei Yamasaki, Hiroaki Ikegami, Kazuhiro Yatera
Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan

O-08

The effect of “super Th1 cells”-derived IL-22 on Th1-type lung inflammation.
○Masakiyo Nakahira1, Tomohiro Yoshimoto1, Etsushi Kuroda1, 2

O-09

1

Department of Immunology, Hyogo College of Medicine

2Lab. of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition

Migratory dendritic cells in skin-draining lymph nodes have Ni-binding capability andelicit Ni allergy.
○Toshinbu Kuroishi1, Kanan Bando1, 2, Shunji Sugawara1
1

Division of Oral Immunology, 2Division of Orthodontics and Dentofacial Orthopedics, Tohoku University

Graduate School of Dentistry, Sendai, Japan

10:20 ～ 10:30

Break

10:30 ～ 11:50 Award Ceremony “JSIT Research Award” and Award Lecture
Chairperson : Reiko Teshima（Faculty of Veterinary Medicine, Okayama University of Sciences)
JSIT Award Lecture
AL-01
An immunotoxicological study in the drug development○Koichi Ueno
Center for Preventive Medical Sciences, Chiba University, Japan

JSIT Young Investigator Award Lecture
AL-02
Vaccine safety evaluation using human peripheral blood mononuclear cells andhumanized mouse model○Eita Sasaki
Department of Safety Research on Blood and Biological Products, National
Institute of Infectious Diseases
AL-03

Interaction between allergy development and exposure to environmental chemicals
including pesticide.
○Tomoki Fukuyama
Azabu University Faculty of Veterinary Medicine, Pharmacology Laboratory

11:50 ～ 12:00

Break

12:00 ～ 12:45

Luncheon Seminar 2 (Charles River Laboratories, Inc.)

LS-02

Cell therapy/Gene Therapy/ nucleotide based immunotoxicity assessment○Séverine Sarlang, Ph.D.
Charles River Evreux, France

12:45 ～ 13:30 Poster Discussion Session 2 ＜Y-01 ～ Y-13、P-1 〜 P-18＞(All posters are presented in this session)
13:30 ～ 13:40

Break13:40 ～ 14:30 Educational Lecture 2
Chairperson : Minoru Satoh (University of Occupational and Environmental Health, Japan)
EL-02

Pros and cons of biological agents in rheumatic diseases○Yoshiya Tanaka
The First Department of Medicine, University of Occupational and Environmental Health, Japan

14:35 ～ 16:35
Chairpersons :Workshop :Shigeru Hisada“Adverse Outcome Pathway (AOP) of immunotoxicityand its goal”(ASKA Pharmaceutical Co., Ltd.)

Tadashi Kosaka（Study Management Division,
The Institute of Environmental Toxicology）
14:35 ～ 14:55
WS-01

AOP project in OECD
○Hajime Kojima
Division of Risk Assessment, Biological Safety Research Center, National Instituteof Health Sciences (NIHS)

14:55 ～ 15:05
WS-02

Development of AOP for immunotoxicity.
○Shigeru Hisada1,2
1

Testing Methodology Committee, the Japanese Society of Immunotoxicology

2

Innovative Drug Discovery Division, ASKA Pharmaceutical Co., Ltd.

15:05 ～ 15:25
WS-03

Development of AOP -Inhibition of Calcineurin Activity Leading to Impaired T-Cell
Dependent Antibody Response○Takumi Ohishi1, 2
1

AOP Working Group, Testing Methodology Committee, The Japanese Society of Immunotoxicology

2

Gotemba Laboratory, BoZo Research Center Inc.

15:25 ～ 15:55
WS-04

Adverse Outcome Pathways on immunotoxicity under development○Shogo Matsumura1
1

AOP Working Group, Testing Methodology Committee, The Japanese Society of Immunotoxicology

2

Drug Safety Research Laboratories, Astellas Pharma Inc.

15:55 ～ 16:20
WS-05

AOP for immunotoxicity caused by inhibition of IL-1 signaling○Setsuya Aiba, Yutaka Kimura
Department of Dermatology, Toyoku University School of Medicine, Japan

16:20 ～ 16:30
WS-06

The goal of immunotoxicity AOP development○Takao Ashikaga1, 21

AOP Working Group, Testing Methodology Committee, The Japanese Society of Immunotoxicology

2National Institute of Health Sciences, Biological Safety Research Center, Division of Risk Assessment

16:35 ～ 16:45

Award Ceremony
Closing Remarks“The Best Presenter Award”