SAFETY DATA SHEETThis safety data sheet was created pursuant to the requirements of:Regulation (EC) No. 1907/2006 and Regulation (EC) No. 2020/2008
Revision Date 06-Dec-2023

Revision Number 5

EGHS / English_____________________________________________________________________________________________

Section 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE
COMPANY/UNDERTAKING
1.1. Product identifier
Product Code(s)Various-Lentiviral particle format

Product Name

SMARTvectorLentiviral shRNA, SMARTvector InducibleLentiviral shRNA,
shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA, GIPZ
Lentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, LentiviraldCas9-VPR, Edit-R Lentiviral sgRNA, CRISPRa Lentiviral sgRNA, Edit-R All-inone Lentiviral sgRNA, CRISPRi Lentiviral Blast-dCas9, CRISPRi Lentiviral sgRNA,FGS CRISPRko

Chemical name
Reach Number

A registration number is not required for this substance.

1.2. Relevant identified uses of the substance or mixture and uses advised against
Recommended Use

For research use only.

Uses advised against

No information available.

1.3. Details of the supplier of the safety data sheet
Supplier Name

Dharmacon Inc.
Horizon Discovery Ltd.

Supplier Address

2650 Crescent Drive Suite 100
Lafayette, CO 80026

Supplier Phone Number

Tel: 303-604-9499
Fax: 303-604-9680

Supplier Emailtechnical@horizondiscovery.com

For further information, please contact.
1.4. Emergency telephone number_____________________________________________________________________________________________

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shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA,GIPZLentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, EditR CRISPRa Lentiviral dCas9-VPR, Edit-R Lentiviral sgRNA, EditR,CRISPRa,Lentiviral sgRNA_____________________________________________________________________________________________

Emergency telephone

Chemtrec International 1-703-741-5970

Emergency telephone §45 - (EC)1272/2008
Europe112

SECTION 2: Hazards identification
2.1. Classification of the substance or mixture
Classification of substance according to Regulation (EC) No 1272/2008 (CLP)
Not a hazardous substance or mixture.

2.2. Label elements
Label elements according to Regulation (EC) No 1272/2008 (CLP)
Not a hazardous substance or mixture.

2.3. Other hazards
Each viral particle stock contains a pure recombinant, replication-defective lentivirus population. Lentiviral vectors are
considered GMO’s. The viral particles are classified as Risk Group 2 by the World Health Organization (WHO) andBiosafety Level 2 (BL2) or Enhanced BL2 (depending on the circumstances) by the U.S. Centers for Disease Control(CDC) Office of Health and Safety.

SECTION 3: Composition/information on ingredients
3.1 SubstancesThis product contains no substances which at their given concentration, are considered to be hazardous to health.
Chemical nameEC No

CAS-NoWeight-%Lentiviral Particles*-

XXX-XX-X

1-99%

Classification according
to Regulation (EC) No.
1272/2008 [CLP]No data available

DMEM**

-

N/A

1-99%

No data available

REACH Reg.
No.
No dataavailable
No dataavailable* Any concentration shown as a range is to protect confidentiality or is due to process variation.
**All components need not be disclosed according to applicable regulations due to non-hazardous classification status.

Full text of H- and EUH-phrases: see section 16
This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC)No. 1907/2006 (REACH), Article 59)
Chemical name
CAS-NoSVHC candidates
DMEM
N/A
Lentiviral Particles
XXX-XX-X-

SECTION 4: First aid measures_____________________________________________________________________________________________

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shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA,GIPZLentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, EditR CRISPRa Lentiviral dCas9-VPR, Edit-R Lentiviral sgRNA, EditR,CRISPRa,Lentiviral sgRNA_____________________________________________________________________________________________

4.1. Description of first aid measures
Inhalation

Remove to fresh air. Administer oxygen if breathing is difficult. Get medical
attention immediately if symptoms occur.

Skin contact

Wash off immediately with soap and plenty of water for at least 15 minutes. Get
medical attention immediately if symptoms occur.

Eye contact

Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower andupper eyelids. Consult a physician.

Ingestion

DO NOT induce vomiting. Get medical attention.

4.2. Most important symptoms and effects, both acute and delayed
Symptoms

No information available.

4.3. Indication of any immediate medical attention and special treatment needed
Note to physicians

Treat symptomatically.

Section 5: FIRE FIGHTING MEASURES
5.1. Extinguishing media
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and thesurrounding environment.

Unsuitable extinguishing media No information available.
5.2. Special hazards arising from the substance or mixture
Specific hazards arising from the chemical
Thermal decomposition can lead to release of irritating and toxic gases and vapors.
5.3. Advice for firefighters
Special protective equipment for fire-fighters
Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. Use personal protection
equipment.

SECTION 6: Accidental release measures
6.1. Personal precautions, protective equipment and emergency procedures
Personal precautions

Use personal protective equipment as required. Avoid contact with skin, eyes orclothing. Ensure adequate ventilation.

For emergency responders

Use personal protection recommended in Section 8.

_____________________________________________________________________________________________

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shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA,GIPZLentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, EditR CRISPRa Lentiviral dCas9-VPR, Edit-R Lentiviral sgRNA, EditR,CRISPRa,Lentiviral sgRNA_____________________________________________________________________________________________

6.2. Environmental precautions
Environmental precautions

Should not be released into the environment. See Section 12 for additional
Ecological Information.

6.3. Methods and material for containment and cleaning up
Methods for containment

Prevent further leakage or spillage if safe to do so.

Methods for cleaning up

Soak up with inert absorbent material. Keep in suitable, closed containers for
disposal.

6.4. Reference to other sections
Reference to other sections

See section 8 for more information. See section 13 for more information.

SECTION 7: Handling and storage
7.1. Precautions for safe handling
Advice on safe handling

Handle in accordance with good industrial hygiene and safety practice. Wear
personal protective equipment. Ensure adequate ventilation. Avoid contact withskin, eyes and clothing. Avoid ingestion and inhalation. This material should be
handled at the biosafety level 2 (BSL2) as required by OSHA Bloodborne Pathogen
Rule (29 CFR 1910.1030.7).

General Hygiene Considerations Handle in accordance with good industrial hygiene and safety practice.
7.2. Conditions for safe storage, including any incompatibilities
Storage Conditions

Keep container tightly closed. Keep at -80°C.

7.3. Specific end use(s)Risk Management Methods(RMM)

The information required is contained in this Material Safety Data Sheet.

Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1. Control parameters
Exposure Limits

This product, as supplied, does not contain any hazardous materials withoccupational exposure limits established by the region specific regulatory bodies

Derived No Effect Level (DNEL) No information available_____________________________________________________________________________________________

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shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA,GIPZLentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, EditR CRISPRa Lentiviral dCas9-VPR, Edit-R Lentiviral sgRNA, EditR,CRISPRa,Lentiviral sgRNA_____________________________________________________________________________________________

Predicted No Effect Concentration (PNEC) No information available
8.2. Exposure controls
Engineering Controls
Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close
to the workstation location.
Personal protective equipment
Eye/face protection

Wear safety glasses with side shields (or goggles).

Hand Protection

Protective gloves.

Skin and body protection

Wear suitable protective clothing.

Environmental exposure
controls

No information available.

SECTION 9: Physical and chemical properties
9.1. Information on basic physical and chemical properties
Physical state
ColourOdour

LiquidYellow
Data not relevant for safe use

Property
Values
Melting / freezing point
Data not relevant for safe use
Boiling point / boiling range
Data not relevant for safe use
Flammability
Data not relevant for safe use
Lower and Upper Exposure Limit
Data not relevant for safe use
Flash Point
Data not relevant for safe use
Auto-ignition Temperature
Data not relevant for safe use
Flammability Limit in Air
Data not relevant for safe use
Decomposition Temperature
Data not relevant for safe use
pH
Data not relevant for safe use
Kinematic viscosity
Data not relevant for safe use
Solubility
Data not relevant for safe use
Partition coefficient: n-octanol/water Data not relevant for safe use
Vapour pressure
Data not relevant for safe use
Density / Relative Density
Data not relevant for safe use
Relative vapour density
Data not relevant for safe use
Decomposition temperature
Data not relevant for safe use
Particle characteristics
Data not relevant for safe use

Remarks Method
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known
None known

9.2. Other information
Softening Point
Molecular Weight
VOC Content (%)

Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use_____________________________________________________________________________________________

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shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA,GIPZLentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, EditR CRISPRa Lentiviral dCas9-VPR, Edit-R Lentiviral sgRNA, EditR,CRISPRa,Lentiviral sgRNA_____________________________________________________________________________________________
Liquid Density
Bulk Density
Particle Size
Particle Size Distribution

Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use
Data not relevant for safe use

SECTION 10: Stability and reactivity
10.1. Reactivity
No data available.
10.2. Chemical stability
Stable under normal conditions.
Explosion Data
Sensitivity to Mechanical Impact
Sensitivity to Static Discharge

None.
None.

10.3. Possibility of hazardous reactions
Possibility of Hazardous
ReactionsNone under normal processing.

Hazardous Polymerization

Hazardous polymerization does not occur.

10.4. Conditions to avoid
Excessive heat.
10.5. Incompatible materials
No information available.
10.6. Hazardous decomposition products
None under normal use conditions.

SECTION 11: Toxicological information
11.1. Information on toxicological effects
Test data is not available for the complete mixture.
Classification procedure
The method for classification of the mixture is based on ingredients of the mixture.
Product Information_____________________________________________________________________________________________

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shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA,GIPZLentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, EditR CRISPRa Lentiviral dCas9-VPR, Edit-R Lentiviral sgRNA, EditR,CRISPRa,Lentiviral sgRNA_____________________________________________________________________________________________
Inhalation

Specific test data for the substance or mixture is not available.

Eye contact

Specific test data for the substance or mixture is not available.

Skin contact

Specific test data for the substance or mixture is not available.

Ingestion

Specific test data for the substance or mixture is not available.

Information on toxicological effects
Symptoms

No information available.

Numerical measures of toxicity
Acute Toxicity

Shall not be classified as acutely toxic.

Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation
No information available.
Serious eye damage/eye
No information available.
irritation
Respiratory or skin sensitization No information available.
Germ cell mutagenicity
No information available.
Carcinogenicity
No information available.
Reproductive Toxicity
No information available.
STOT - single exposure
No information available.
STOT - repeated exposure
No information available.
Aspiration hazard
No information available.
11.2. Endocrine disrupting properties
This product does not contain known or suspected endocrine disruptors.

SECTION 12: Ecological information
12.1. Ecotoxicity
No information available.
12.2. Persistence and degradability
No information available.
12.3. Bioaccumulative potential
No information available.
12.4. Mobility in soil_____________________________________________________________________________________________

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shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA,GIPZLentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, EditR CRISPRa Lentiviral dCas9-VPR, Edit-R Lentiviral sgRNA, EditR,CRISPRa,Lentiviral sgRNA_____________________________________________________________________________________________
No information available.
12.5. Results of PBT and vPvB assessment
No information available.
12.6. Endocrine disrupting properties
This product does not contain known or suspected endocrine disruptors.
12.7 Other adverse effects
Data not available.

SECTION 13: Disposal considerations
13.1. Waste treatment methods
Waste from residues/unused
products

Dispose of in accordance with local regulations. Dispose of waste in accordancewith environmental legislation.

Contaminated packaging

No information available.

SECTION 14: Transport information
IMDG
14.1 UN Number
14.2 Proper Shipping Name
14.3 Hazard Class
14.4 Packing group
14.5 Marine Pollutant
14.6 Special Provisions
14.7 Transport in bulk
according to Annex II of
MARPOL and the IBC CodeRID
14.1 UN-No.
14.2 Proper Shipping Name
14.3 Hazard Class
14.4 Packing Group14.5 Environmental hazard
14.6 Special Provisions

Not regulated
Not regulated
Not regulated
Not regulated
Not applicableNone
Not applicableNot regulated
Not regulated
Not regulated
Not regulated
Not applicable
None

ADR
14.1 UN-No.
UN324514.2 Proper Shipping Name
Genetically Modified Micro-Organism
14.3 Hazard Class9
14.4 Packing Group
III
14.5 Environmental hazard
Not applicable_____________________________________________________________________________________________

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IATA
14.1 UN Number
14.2 Proper Shipping Name
14.3 Hazard Class
Subsidiary class
14.4 Packing group
14.5 Environmental hazard
14.6 Special Provisions

UN3245GMMO
9III
Not regulated
Not applicable
None

SECTION 15: Regulatory information
15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related tochemical agents at work .
Authorizations and/or restrictions on use:
This product does not contain substances subject to authorization (Regulation (EC) No. 1907/2006 (REACH), Annex
XIV). This product does not contain substances subject to restriction (Regulation (EC) No. 1907/2006 (REACH),
Annex XVII).
Persistent Organic Pollutants
Not applicable.
Ozone-depleting substances (ODS) regulation (EC) 1005/2009
Not applicable.
International Inventories
TSCA
DSL/NDSL
EINECS/ELINCS
ENCS
IECSC
KECL
PICCS
AICS

Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.

LegendTSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical
Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances_____________________________________________________________________________________________

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shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA,GIPZLentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, EditR CRISPRa Lentiviral dCas9-VPR, Edit-R Lentiviral sgRNA, EditR,CRISPRa,Lentiviral sgRNA_____________________________________________________________________________________________PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances
15.2. Chemical safety assessment
No information available.

SECTION 16: Other information
Key or legend to abbreviations and acronyms used in the safety data sheet
Legend
SVHC: Substances of Very High Concern for Authorization:
Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTIONTWATWA (time-weighted average)
STEL
Ceiling
Maximum limit value-

STEL (Short Term Exposure Limit)
Skin designation

Key literature references and sources for data
www.ChemADVISOR.com/
Revision Date

06-Dec-2023

This safety data sheet complies with the requirements of: Regulation (EC) No. 1907/2006 and Regulation (EC)No. 2020/2008.
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information andbelief at the date of its publication. The information given is designed only as a guidance for safe handling,use, processing, storage, transportation, disposal and release and is not to be considered a warranty or
quality specification. The information relates only to the specific material designated and may not be valid forsuch material used in combination with any other materials or in any process, unless specified in the text.
End of Safety Data Sheet

Data for Regulatory Rules_____________________________________________________________________________________________

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