Chapter 12
Senile Dementia of the Neurofibrillary
Tangle TypeCQ 12-1

What kind of disease is senile dementia of the neurofibrillary tangle type(SD-NFT)?
AnswerSD-NFT is a subtype of senile dementia characterized by numerous neurofibrillary tangles (NFTs) mainly in thehippocampus but very few senile plaques. This disease is often diagnosed clinically as Alzheimer’s disease dementia.

Comments and evidence
1. Concept

SD-NFT is a subtype of senile dementia characterized by the presence of numerous NFTs mainly in the hippocampus,
and the incidence increases with aging. SD-NFT is reported to constitute 1.7-5.6% of autopsy cases of dementia in older
people and account for 20% of dementia cases in those over 90 years of age 1). Among the dementia cases in the Hisayama
study, 2.9% was classified as SD-NFT, and the percentage was 4.9% when limited to autopsy cases 2). On the other hand,
the term “primary age-related tauopathy (PART)” has been proposed as a pathological term for the condition in which NFTs
are chiefly distributed in the medial temporal lobe while senile plaques are absent or very scarce 3, 4). Clinically, this isperceived as a concept of spectrum including the states from normal cognitive function to dementia through mild cognitiveimpairment.

2. Clinical features
SD-NFT is considered to be a pathological condition of accelerated aging process of the brain. The clinical features are as
follows 1, 3, 5):(1) Common in the late old age(2) Progresses slowly(3) Memory impairment as onset symptom(4) Other cognitive impairments and personality changes are relatively mild
(5) Rare appearance of delirium and extrapyramidal symptoms(6) Imaging study shows atrophy of hippocampal region and expansion of inferior horn of lateral ventricle.

3. Differential diagnosis
Many cases of SD-NFT are diagnosed during life as Alzheimer’s disease dementia, and many pathological findings ofSD-NFT overlap with those of argyrophilic grain dementia and vascular lesions.
Although SD-NFT shares many common clinical features with late-onset Alzheimer’s disease dementia, such as memory
impairment as the core symptom and lesions enhanced in the medial temporal lobe, SD-NFT is a more slowly progressivedisease, and amyloid PET is useful for differentiation.
Both argyrophilic grain dementia and SD-NFT are classified as late-onset tauopathy, and the two share common features
including lesion in the medial temporal lobe and memory impairment as onset symptom. However, in argyrophilic graindementia, although memory impairment is the main feature, other symptoms such as irritability, behavioral abnormalities,
and personality change are a characteristic feature and useful for differentiation. In addition, the medial temporal lobe
atrophy in argyrophilic grain dementia is asymmetric, which is also a differentiation feature. The medial temporal lobe
atrophy is anterior-dominant in argyrophilic grain dementia but is relatively prominent at the posterior side in SD-NFT .
These features are helpful in differential diagnosis 1, 3, 5).

4. Treatment
In clinical practice, SD-NFT is often diagnosed as Alzheimer’s disease dementia and treated with cholinesterase inhibitors.
There are currently no therapies that have proven efficacy for SD-NFT 1, 3, 5).

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Clinical Practice Guideline for Dementia 2017▪ References1) Yamada M. Neurological syndromes (second edition) II: Senile dementia of the neurofibrillary tangle type. Japanese Journal of Clinical Medicine
Supplement (Bessatsu Nippon Rinsho) 2014; (27): 51-56. (In Japanese)
2) Matsui Y, Tanizaki Y, Arima H, et al. Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama study. J Neurol
Neurosurg Psychiatry. 2009; 80(4): 366-370.
3) Yamada M. Senile dementia of the neurofibrillary tangle type (tangle-only dementia): neuropathological criteria and clinical guidelines for diagnosis.
Neuropathology. 2003; 23(4): 311-317.
4) Yamada M. On the concept of senile dementia of the neurofibrillary tangle type (SD-NFT) and primary age-related tauopathy (PART). Dementia
Jpn. 2016; 30: 103-111. (In Japanese)
5) Crary JF, Trojanowski JQ, Schneider JA, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta
Neuropathol. 2014; 128(6): 755-766.

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