Publication List (Takashi Ohshima)
148)

Catalytic

Enantioselective

Strecker

ReactionofIsatin-Derived

N-

Unsubstituted Ketimines. T. Kadota, M. Sawa, Y. Kondo, H. Morimoto, T. Ohshima,
Org. Lett., 23, 4553–4558 (2021).
DOI: 10.1021/acs.orglett.1c01194

Highlighted as Cover Picture147) C‒C Bond Cleavage of Unactivated 2-Acylimidazoles. H.-L. Xin, B. Pang, J. Choi,
W. Akkad, H. Morimoto, T. Ohshima, J. Org. Chem., 85, 11592‒11606 (2020).
https://dx.doi.org/10.1021/acs.joc.0c01458

146) Recent Progress on Catalytic Addition Reactions to N-Unsubstituted Imines. K.

Morisaki, H. Morimoto, T. Ohshima, ACS Catal., 10, 6924‒6951 (2020).
https://dx.doi.org/10.1021/acscatal.0c01212

145) Catalytic Aerobic Cross-Dehydrogenative Coupling of Azlactones en Route toa,a-Disubstituted a-Amino Acids. T. Tsuji, T. Tanaka, T. Tanaka, R. Yazaki, T.

Ohshima, Org. Lett., 22, 4164‒4170 (2020)
https://doi.org/10.1021/acs.orglett.0c01248

144) Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly
Congested Unnatural a-Amino Acid Synthesis. Y. Matsumoto, J. Sawamura, Y. Murata,
T. Nishikata, R. Yazaki, T. Ohshima, J. Am. Chem. Soc., 142, 8498–8505 (2020).
https://dx.doi.org/10.1021/jacs.0c02707
Press Release on Kyushu University website(https://www.kyushu-u.ac.jp/ja/researches/view/442)

143) Recent Progress towards the Use of Benzophenone Imines as an Ammonia
Equivalent. Y. Kondo, H. Morimoto, T. Ohshima, Chem. Lett., 49, 467–504 (2020).
https://doi.org/10.1246/cl.200099

142) Chemoselective Catalytic a-Oxidation of Carboxylic Acids: Iron/Alkali Metal
Cooperative Redox Active Catalysis. T. Tanaka, R. Yazaki, T. Ohshima, J. Am. Chem.
Soc., 142, 4517–4524 (2020).
https://dx.doi.org/10.1021/jacs.0c00727
Press Release on Kyushu University website(https://www.kyushu-u.ac.jp/ja/researches/view/427)

141) Rhodium(I)/Chiral Diene-Catalyzed Enantioselective Addition of Boronic
Acids to N-Unsubstituted Isatin-Derived Ketimines. R. Yonesaki, I. Kusagawa, H.
Morimoto, T. Hayashi, T. Ohshima, Chem. Asian. J., 15, 499–502 (2020).
https://doi.org/10.1002/asia.201901745
Highlighted by ChemistryViews(https://www.chemistryviews.org/details/ezine/11214635/Addition_of_Boronic_Acids_t
o_NUnsubstituted_Ketimines.html)

140) Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines.

Y. Kondo, T. Kadota, Y. Hirazawa, K. Morisaki, H. Morimoto, T. Ohshima, Org. Lett., 22,
120–125 (2020).
https://pubs.acs.org/doi/10.1021/acs.orglett.9b04038
Press Release on Kyushu University website(https://www.kyushu-u.ac.jp/ja/researches/view/408)

139) Identification of candidate molecular targets of the novel antineoplastic
antimitotic NP-10. T. Yokoyama, M. Yukuhiro, Y. Iwasaki, C. Tanaka, K. Sankoda, R.
Fujiwara, A. Shibuta, T. Higashi, K. Motoyama, H. Arima, K. Yoshida, N. Sugimoto, H.
Morimoto, H. Kosako, T. Ohshima, M. Fujita, Sci. Rep., 9, 16825–16837 (2019).
https://doi.org/10.1038/s41598-019-53259-2
138) Recent strategic advances for the activation of benzylic C–H bonds for theformation of C–C bonds. R. Yazaki, T. Ohshima, Tetrahedron Lett., 60, 151225–151236(2020).
https://doi.org/10.1016/j.tetlet.2019.151225

137) Mechanistic Studies of Nickel(II)-Catalyzed Direct Alcoholysis of 8Aminoquinoline Amides. H. Morimoto, W. Akkad, T. Deguchi, T. Ohshima,
Heterocycles, 101, 471–485 (2020).
DOI: 10.3987/COM-19-S(F)30

136) A Convenient Preparation Method for Benzophenone Imine Catalyzed by
Tetrabutylammonium Fluoride. Y. Kondo, K. Morisaki, Y. Hirazawa, H. Morimoto, T.
Ohshima, Org. Process Res. Dev., 23, 1718–1724 (2019).
https://pubs.acs.org/doi/10.1021/acs.oprd.9b00226

135)

Thionoesters

as

1,2-Dipolarophiles

for

[4+2]

Cycloaddition

with

Cyclobutanones. Y. Matsumoto, T. Tsuji, D. Nakatake, R. Yazaki, T. Ohshima, Asian J.
Org. Chem., 8, 1071–1074 (2019).
https://doi.org/10.1002/ajoc.201900156

134) Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides:
Mechanistic Investigation and Application to a Microwave Flow Process. M. Noshita,
Y. Shimizu, H. Morimoto, S. Akai, Y. Hamashima, N. Ohneda, H. Odajima, T. Ohshima,
Org. Process Res. Dev., 23, 588–594 (2019).

https://pubs.acs.org/doi/10.1021/acs.oprd.8b00424

133)

MECHANISTIC

INSIGHTINTOCATALYTICAEROBICCHEMOSELECTIVE α-OXIDATION OF ACYLPYRAZOLES. S. Taninokuchi, R.
Yazaki, T. Ohshima, Heterocycles, 99, 906–918 (2019).
DOI: 10.3987/COM-18-S(F)58

132) Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of
N-Unprotected Isatin-Derived Ketimines. M. Sawa, S. Miyazaki, R. Yonesaki, H.
Morimoto, T. Ohshima, Org. Lett., 20, 5393–5397 (2018).
https://pubs.acs.org/doi/10.1021/acs.orglett.8b02306

131) 3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in
Direct Enantioselective Friedel-Crafts-Type Alkylation of N-Unprotected a-

Ketiminoester. R. Yonesaki, Y. Kondo, W. Akkad, M. Sawa, K. Morisaki, H. Morimoto,
T. Ohshima, Chem. Eur. J., 24, 15211–15214 (2018).
https://doi.org/10.1002/chem.201804078

130)

Chemoselective

Catalytic

Dehydrogenative

Cross-Couplingof

2-Acylimidazoles: Mechanistic Investigations and Synthetic Scope. T. Tanaka, K.
Hashiguchi, T. Tanaka, R. Yazaki, T. Ohshima, ACS Catal., 8, 8430–8440 (2018).
https://pubs.acs.org/doi/abs/10.1021/acscatal.8b02361

129) Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via aTransient Homocoupling Dimer. T. Tanaka, T. Tanaka, T. Tsuji, R. Yazaki, T. Ohshima,
Org. Lett., 20, 3541–3544 (2018).
DOI 10.1021/acs.orglett.8b01313

128) Growth suppression of human colorectal cancer cells with mutated KRAS by
3-deaza-cytarabine in 3d floating culture. H. Luo, K. Nishi, S. Ishikura, A. Swain, N.
Morishige, R. Yazaki, T. Ohshima, S. Shirasawa, T. Tsunoda, Anticancer research, 38,

4247–4256 (2018).
DOI 10.21873/anticanres.12721
127) An Expeditious Route to trans-Configured Tetrahydrothiophenes Enabled by
Fe(OTf)3-Catalyzed [3+2] Cycloaddition of Donor–Acceptor Cyclopropanes withThionoesters. Y. Matsumoto, D. Nakatake, R. Yazaki, T. Ohshima, Chem. Eur. J., 24,
6062–6066 (2018).
DOI: 10.1002/chem.201800957

126) Bioconjugation with Thiols by Benzylic Substitution. K. Watanabe, T. Ohshima,
Chem. Eur. J., 24, 3959–3964 (2018).
DOI: 10.1002/chem.201706149
This paper was highlighted as a Hot Paper.
Press Release on Kyushu University website(https://www.kyushu-u.ac.jp/ja/researches/view/220)
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125) Development of Direct Enantioselective Alkynylation of a-Ketoester and aKetiminoesters Catalyzed by Phenylbis(oxazoline)Rh(III) Complexes. K. Morisaki,
H. Morimoto, K. Mashima, T. Ohshima, Journal of Synthetic Organic Chemistry, Japan,
76, 226–240 (2018).
doi.org/10.5059/yukigoseikyokaishi.76.226
124) Boronic Acid Accelerated Three-Component Reaction for the Synthesis of aSulfanyl-Substituted Indole-3-acetic Acids. A. Das, K. Watanabe, H. Morimoto, T.
Ohshima, Org. Lett., 19, 5794–5797 (2017).
DOI: 10.1021/acs.orglett.7b02727

123) Direct Access to N-Unprotected a- and/or b-Tetrasubstituted Amino Acid
Esters via Direct Catalytic Mannich-Type Reactions Using N-Unprotected
Trifluoromethyl Ketimines. M. Sawa, K. Morisaki, Y. Kondo, H. Morimoto, T. Ohshima,

Chem. Eur. J., 23, 17022–17028 (2017).
DOI: 10.1002/chem.201703516(Cover Feature DOI: 10.1002/chem.201704439)
Press Release on Kyushu University website(https://www.kyushu-u.ac.jp/ja/researches/view/220)
Press Release on Nikkei.com(https://www.nikkei.com/article/DGXLRSP458408_X20C17A9000000/)
This paper was highlighted by ResearchGate.
(https://www.researchgate.net/publication/320179056_Direct_Access_to_NUnprotected_a-_andor_bTetrasubstituted_Amino_Acid_Esters_via_Direct_Catalytic_MannichType_Reactions_Using_N-Unprotected_Trifluoromethyl_Ketimines)122) Synthesis of 1-Tetrasubstituted 2,2,2-Trifluoroethylamine Derivatives via
Palladium-Catalyzed Allylation of sp3 C–H Bonds. K. Morisaki, Y. Kondo, M. Sawa,
H. Morimoto, T. Ohshima, Chem. Phar. Bull., 65, 1089–1092 (2017).
DOI: 10.1248/cpb.c17-00580

121) Catalytic Aerobic Chemoselective a-Oxidation of Acylpyrazoles en Route to aHydroxy Acid Derivatives. S. Taninokuchi, R. Yazaki, T. Ohshima, Org. Lett., 19, 3187–
3190 (2017).
DOI: 10.1021/acs.orglett.7b01293
This paper was highlighted by Organic Chemistry Portal.
(http://www.organic-chemistry.org/Highlights/2018/19March.shtm)120) Direct access to N-unprotected tetrasubstituted propargylamines via direct
catalytic alkynylation of N-unprotected trifluoromethyl ketimines. K. Morisaki, H.
Morimoto, T. Ohshima, Chem. Commun., 53, 6319–6322 (2017).
DOI: 10.1039/c7cc02194a
Press Release on Kyushu University website(http://www.kyushu-u.ac.jp/ja/researches/view/117)
Press Release on Nikkei.com(https://www.nikkei.com/article/DGXLRSP444089_R00C17A5000000/)
This paper was highlighted by ChemStation as a Spotlight Research.
(http://www.chem-station.com/blog/2017/07/aminsynthesis.html)

119) Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides. T.
Deguchi, H.-L. Xin, H. Morimoto, T. Ohshima, ACS Catal., 7, 3157–3161 (2017).
DOI: 10.1021/acscatal.7b00442

118) DIRECT ENANTIOSELECTIVE ALKYNYLATION OF a-KETOESTERS
AND

a-KETIMINOESTERSCATALYZEDBY[BIS(OXAZOLINE)PHENYL]RHODIUM(III) COMPLEXES. K. Morisaki, H.
Morimoto, K. Mashima, T. Ohshima, Heterocycles, 95, 637–661 (2017).
DOI: 10.3987/REV-16-SR(S)4
PREFACE TO HETEROCYCLES ISSUEHONORING

THE

70TH

BIRTHDAYOF

PROFESSORSHIBASAKI. T. Ohshima, Heterocycles, 95, 3–6 (2017).
DOI: 10.3987/COM-16-S(S)Foreword_2

MASAKATSU

117) Metabolomic profiling of brain tissues of mice chronically exposed to heroin. R.
Li, T. Takeda, T. Ohshima, H. Yamada, Y. Ishii, Drug Metab. Pharmacokinet., 32, 108–111 (2017).
DOI: 10.1016/j.dmpk.2016.10.410.

116) Catalytic Chemoselective Conjugate Addition of Amino Alcohols to a,bUnsaturated Ester: Hydroxy Group over Amino Group and Conjugate Addition
over Transesterification. Z. Li, M. Tamura, R. Yazaki, T. Ohshima, Chem. Pharm. Bull.,
65, 19–21 (2017).
DOI: 10.1248/cpb.c16-00333
Foreword. H. Fujioka, T. Ohshima, Chem. Pharm. Bull., 65, 1 (2017).
DOI: 10.1248/cpb.c17-ctf6501

115）Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates andUreas. M. Noshita, Y. Shimizu, H. Morimoto, T. Ohshima, Org. Lett., 18, 6062–6065(2016).
DOI: 10.1021/acs.orglett.6b03016
This paper was highlighted by Organic Chemistry Portal.
(http://www.organic-chemistry.org/abstracts/lit5/673.shtm)

114) Chemo- and Regioselective Direct Functional Group Installation throughCatalytic Hydroxy Group Selective Conjugate Addition of Amino Alcohols to a,bUnsaturated Sulfonyl Compounds. Z. Li, R. Yazaki, T. Ohshima, Org. Lett., 18, 3350–
3353 (2016).
DOI: 10.1021/acs.orglett.6b01464

113) Chemoselective Transesterification of Acrylate Derivatives for Functionalized
Monomer Synthesis Using a Hard Zinc Alkoxide Generation Strategy. D. Nakatake,R. Yazaki, T. Ohshima, Eur. J. Org. Chem., 3696–3699 (2016).
DOI: 10.1002/ejoc.201600737

112) µ-Oxo-Dinuclear-Iron(III)-Catalyzed O-Selective Acylation of Aliphatic andAromatic Amino Alcohols and Transesterification of Tertiary Alcohols. R. Horikawa,
C. Fujimoto, R. Yazaki, T. Ohshima, Chem. Eur. J., 22, 12278–12281 (2016).
DOI: 10.1002/chem.201602801
Press Release on Kyushu University website(https://www.kyushu-u.ac.jp/ja/researches/view/27)

111) Isomeric iodinated analogs of nimesulide: synthesis, physicochemical
characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2
cells. Y. Yamamoto, J. Arai, T. Hisa, Y. Saito, T. Mukai, T. Ohshima, M. Maeda, F.
Yamamoto, Bioorg. Med. Chem., 24, 3727–3733 (2016).
DOI: doi.org/10.1016/j.bmc.2016.06.015
https://doi.org/10.1016/j.bmc.2016.06.015

110) Mechanistic Studies and Expansion of the Substrate Scope of Direct
Enantioselective Alkynylation of a-Ketiminoesters Catalyzed by Adaptable(Phebox)Rh(III) Complexes. K. Morisaki, M. Sawa, R. Yonesaki, H. Morimoto, K.

Mashima, T. Ohshima, J. Am. Chem. Soc., 138, 6194–6203 (2016).
DOI: 10.1021/jacs.6b01590
Press Release on Kyushu University website(http://www.kyushu-u.ac.jp/ja/researches/view/18)
This paper was highlighted by ChemStation as a Spotlight Research.
(http://www.chem-station.com/blog/2016/06/ohsima.html)

109) Transesterification Reaction Catalyzed by Recyclable Heterogeneous
Zinc/Imidazole Catalyst. D. Nakatake, R. Yazaki, Y. Matsushima, T. Ohshima, Adv.
Synth. Catal., 358, 2569–2574 (2016).
DOI: 10.1002/adsc.201600229
Press Release on Kyushu University website(http://www.kyushu-u.ac.jp/ja/researches/view/21)* This paper was highlighted by Synfacts, 12, 1206 (2016).

108) Synthesis of radioiodinated probes to evaluate the biodistribution of a potent

TRPC3 inhibitor. M. Hagimori, T. Murakami, K. Shimizu, M. Nishida, T. Ohshima, T.
Mukai, MedChemComm, 7, 1003–1006 (2016).
DOI: 10.1039/c6md00023a

107) Development of Tetranuclear Zinc Cluster-Catalyzed Environmentally
Friendly Reactions and Mechanistic Studies. T. Ohshima, Chem. Pharm. Bull., 64,
523–539 (2016).
DOI: 10.1248/cpb.c16-00028

106) Studies of the Electronic Effects of Zinc Cluster Catalysts and Their
Application to the Transesterification of b-Keto Esters. K. Agura, Y. Hayashi, M.
Wada, D. Nakatake, K. Mashima, T. Ohshima, Chem. Asian J., 11, 1548–1554 (2016).
DOI: 10.1002/asia.201600062

105) Direct Catalytic Chemoselective a-Amination of Acylpyrazoles: A Concise
Route to Unnatural a-Amino Acid Derivatives. K. Tokumasu, R. Yazaki, T. Ohshima,
J. Am. Chem. Soc., 138, 2664–2669 (2016).
DOI: 10.1021/jacs.5b11773
Ranked in Monthly Most Read Articles (2016/February)
Press Release on Kyushu University website(http://www.kyushu-u.ac.jp/ja/researches/view/20)

104) A Highly Stable but Highly Reactive Zinc Catalyst for Transesterification
Supported by Bis(imidazole) Ligand. D. Nakatake, Y. Yokote, Y. Matsushima, R.
Yazakia, T. Ohshima, Green. Chem., 18, 1524–1530 (2016).
DOI: 10.1039/c5gc02056e

103) Isomeric Methoxy Analogs of Nimesulide for Development of Brain

Cyclooxygense-2 (COX-2) -targeted Imaging Agents: Synthesis, in Vitro COX-2Inhibitory Potency, and Cellular Transport Properties. Y. Yamamoto, T. Hisa, Takuya.
J. Arai, Y. Saito, Y. Yamamoto, T. Mukai, T. Ohshima, M. Maeda, Y. Ohkubo, Bioorg.
Med. Chem., 23, 6807–6814 (2015).
DOI: 10.1016/j.bmc.2015.10.007

102) A novel anti-microtubule agent with carbazole and benzohydrazide structures
suppresses tumor cell growth in vivo. M. Ohira, Y. Iwasaki, C. Tanaka, M. Kuroki, N.
Matsuo, T. Kitamura, M. Yukuhiro, H. Morimoto, N. Pang, B. Liu, T. Kiyono, M.
Amemiya, K. Tanaka, K. Yoshida, N. Sugimoto, T. Ohshima, M. Fujita, Biochimica etBiophysica Acta (BBA) - General Subjects, 1850, 1676–1684 (2015).
DOI:10.1016/j.bbagen.2015.04.013

101) Radiolabeled g-polyglutamic acid complex as a nano-platform for sentinel
lymph node imaging. K. Sano, Y. Iwamiya, T. Kurosaki, M. Ogawa, Y. Magata, H.
Sasaki, T. Ohshima, M. Maeda, T. Mukai, Journal of Controlled Release, 194, 310–315(2014).
DOI: 10.1016/j.jconrel.2014.08.025

100) A Short Scalable Route to (– )-a-Kainic Acid Using Pt-Catalyzed Direct Allylic
Amination. M. Zhang, K. Watanabe, M. Tsukamoto, R. Shibuya, H. Morimoto, T.
Ohshima, Chem. Eur. J., 21, 3937–3941 (2015).
DOI: 10.1002/chem.201406557

99) Sodium Methoxide-Catalyzed Direct Amidation of Esters. K. Agura, T. Ohshima,
Y. Hayashi, K. Mashima, Org. Synth., 91, 201–210 (2014).
DOI: 10.15227/orgsyn091.01xx
98) Cleavage of unactivated amide bonds by ammonium salt-accelerated
hydrazinolysis. Y. Shimizu, M. Noshita, Y. Mukai, H. Morimoto, T. Ohshima, Chem.
Commun., 50, 12623–12625 (2014).
DOI: 10.1039/c4cc02014f* This paper was highlighted by Organic Chemistry Portal.
http://www.organic-chemistry.org/Highlights/2015/08June.shtm

97) Lanthanum(III) Triflate-Catalyzed Direct Amidation of Esters. H. Morimoto, R.
Fujiwara, Y. Shimizu, K. Morisaki, T. Ohshima, Org. Lett., 16, 2018-2021 (2014).
DOI: 10.1021/ol500593v

96) Dual Platinum and Pyrrolidine Catalysis in the Direct Alkylation of Allylic
Alcohols: Selective Synthesis of Monoallylation Products. R. Shibuya, L. Lin, Y.
Nakahara, K. Mashima, T. Ohshima, Angew. Chem. Int. Ed., 53, 4377–4381 (2014).
DOI: 10.1002/anie.201311200

95) Chemoselective Catalytic Conjugate Addition of Alcohols over Amines. S. Uesugi,
Z. Li, R. Yazaki, T. Ohshima, Angew. Chem. Int. Ed., 53, 1611–1615 (2014).
DOI: 10.1002/anie.201309755

94) Transition Metal Clusters As Catalysts for Chemoselective Transesterificationof Alcohols in the Presence of Amines. K. Mashima, Y. Hayashi, K. Agura, T. Ohshima,
Pure Appl. Chem., 86, 335–343 (2014).
DOI: 10.1515/pac-2014-5036
93) Rh-Catalyzed Direct Enantioselective Alkynylation of a-Ketiminoesters. K.
Morisaki, M. Sawa, J.-y. Nomaguchi, H. Morimoto, Y. Takeuchi, K. Mashima, T.
Ohshima, Chem. Eur. J., 19, 8417-8420 (2013).

DOI: 10.1002/chem.201301237* This paper was highlighted by Synfacts, 9, 976 (2013).

92) Enzyme-like Catalysis via Ternary-Complex Mechanism: Alkoxy-bridged
Dinuclear Cobalt Complex Mediates Chemoselective O-Esterification over NAmidation. Y. Hayashi, S. Santoro, Y. Azuma, F. Himo, T. Ohshima, K. Mashima, J. Am.
Chem. Soc., 135, 6192-6199 (2013).
DOI: 10.1021/ja400367h

91) Platinum-Catalyzed Direct Amination of Allylic Alcohols. T. Ohshima, K.
Mashima, Journal of Synthetic Organic Chemistry, Japan, 70, 1145–1156 (2012).
DOI:10.5059/yukigoseikyokaishi.70.1145
90) Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols,
Including Electron-Withdrawing Group-Substituted Benzhydrols. T. Ohshima, J.
Ipposhi, Y. Nakahara, R. Shibuya, K. Mashima, Adv. Synth. Catal., 354, 2447–2452(2012).
DOI: 10.1002/adsc.201200536

89) Microwave-Assisted Deacylation of Unactivated Amides to Amines Using
Ammonium Salt-Accelerated Transamidation.

Y. Shimizu, H. Morimoto, M. Zhang,

T. Ohshima, Angew. Chem. Int. Ed., 51, 8564–8567 (2012).
DOI: 10.1002/anie.201202354

88) Asymmetric Autoinduction in Hydrogenation of 2-Substituted Quinoxalines
Catalyzed by Iridium Complexes bearing Chiral Diphosphine Ligand.

T. Nagano

A. Iimuro, T. Ohshima, Y. Kita, K. Mashima, Chem. Eur. J., 18, 11578–11592 (2012).
DOI: 10.1002/chem.201201366

87) Highly Efficient and General Asymmetric Hydrogenation of 2-Alkyl- and 2Aryl-Substituted Quinoxaline Derivatives Catalyzed by Iridium-Difluorphos:
Halide Effect and Synthetic Application.

D. Cartigny, F. Berhal, T. Nagano, P.

Phansavath, T. Ayad, J.-P., Genêt, T. Ohshima, K. Mashima, V. Ratovelomanana-Vidal, J.
Org. Chem., 77, 4544–4556 (2012).
DOI: 10.1021/jo300455y

86) Sodium methoxide: a simple but highly efficient catalyst for the direct amidationof esters.

T. Ohshima, Y. Hayashi, K. Agura, Y. Fujii, A. Yoshiyama, K. Mashima,

Chem. Commun., 48, 5434–5436 (2012).
DOI: 10.1039/c2cc32153j

85) Efficient cyclic carbonate synthesis catalyzed by zinc cluster systems under mild
conditions.

Y. Yang, Y. Hayashi, Y. Fujii, T. Nagano, Y. Kita, T. Ohshima, J. Okuda, K.

Mashima, Catal. Sci. Tech., 2, 509–513 (2012).
DOI: 10.1039/C1CY00404B

84) Platinum-Catalyzed Direct Amination of Allylic Alcohols with Aqueous
Ammonia for Selective Synthesis of Primary Allylamines. K. Das, R. Shibuya, Y.
Nakahara, N. Germain, T. Ohshima, K. Mashima, Angew. Chem. Int. Ed., 51, 150–154(2012).
DOI: 10.1002/anie.201106737

83) Transesterification of a-Amino Esters Catalyzed by a Tetranuclear Zinc Custer,Zn4(OCOCF3)6O. Y. Maegawa, K. Agura, Y. Hayashi, T. Ohshima, K. Mashima, Synlett,23, 137–141 (2012).
DOI: 10.1055/s-0031-1290096

82) Additive Effect of N-Heteroaromatics on Transesterification Catalyzed by
Tetranuclear Zinc Cluster. Y. Maegawa, T. Ohshima, Y. Hayashi, K. Agura, T. Iwasaki,
K. Mashima, ACS Catal., 1, 1178–1182 (2011).
DOI: /10.1021/cs200224b

81) Direct substitution of the hydroxy group with highly functionalized nitrogen
nucleophiles catalyzed by Au(III). T. Ohshima, Y. Nakahara, J. Ipposhi, Y. Miyamoto,
K. Mashima, Chem. Commun., 47, 8322–8324 (2011).
DOI: 10.1039/c1cc12760h80) C1-Symmetric Rh-Phebox-Catalyzed Asymmetric Alkynylation of a-Keto Ester.
T. Ohshima, T. Kawabata, Y. Takeuchi, T. Kakinuma, T. Iwasaki, T. Yonezawa, H.
Murakami, H. Nishiyama, K. Mashima, Angew. Chem. Int. Ed. 50, 6296-6300 (2011).
DOI: 10.1002/anie.201100252* This paper was highlighted by Synfacts, 7, 967 (2011) (SYNFACTS of the month).

79) Trifluoroacetic Acid Adduct of Trifluoroacetate-Bridged µ4-Oxo-Tetranuclear
Zinc Cluster, Zn4(OCOCF3)6O•CF3CO2H: Synthesis under Mild Conditions andCatalytic Transesterification and Oxazoline Formation. Y. Hayashi, T. Ohshima, Y.
Fujii, Y. Matsushima, K. Mashima, Catal. Sci. Tech. 1, 230-233 (2011).
DOI: 10.1039/c0cy00048e

78) A Tetranuclear Zinc Cluster-Catalyzed Practical and Versatile Deprotection ofAcetates and Benzoates. T. Iwasaki, K. Agura, Y. Maegawa, Y. Hayashi, T. Ohshima, K.
Mashima, Chem. Eur. J., 16, 11567-11571 (2010).
DOI: 10.1002/chem.201000960

77) Iridium-Difluorphos Catalyzed Asymmetric Hydrogenation of 2-Alkyl and 2Aryl-Substituted

Quinoxalines:

A

Generaland

Efficient

Route

into

Tetrahydroquinoxalines. D. Cartigny, T. Nagano, T. Ayad, J.-P. Genêt, T. Ohshima, K.
Mashima, V. Ratovelomanana-Vidal, Adv. Synth. Catal., 352, 1886-1891 (2010).
DOI: 10.1002/adsc.201000513

76) Asymmetric Hydrogenation of Heteroaromatic Ketones and Cyclic and Acyclic
Enones Mediated by Cu(I)–Chiral Diphosphine Catalysts. H. Shimizu, T. Nagano, N.
Sayo, T. Saito, T. Ohshima, K. Mashima, Synlett, 3143-3146 (2009).
DOI: 10.1055/s-0029-1218347

75) Platinum-Catalyzed Direct Amination of Allylic Alcohols under Mild

Conditions: Ligand and Microwave Effects, Substrate Scope, and Mechanistic Study.
T. Ohshima, Y. Miyamoto, J. Ipposhi, Y. Nakahara, M. Utsunomiya, K. Mashima, J. Am.
Chem. Soc., 131, 14317-14328 (2009).
DOI: 10.1021/ja9046075

74) Unprecedented Halide Dependence on Catalytic Asymmetric Hydrogenation of
2-Aryl- and 2-Alkyl-substituted Quinolinium Salts Using Ir–DIFLUORPHOSHalide Complexes. H. Tadaoka, D. Cartigny, T. Nagano, T. Gosavi, T. Ayad, J.-P. Genêt,T. Ohshima, V. Ratovelomanana-Vidal, K. Mashima, Chem. Eur. J., 15, 9990-9994 (2009).
DOI: 10.1002/chem.200901477* This paper was highlighted by Synfacts, 6, 54 (2010).

73) Theoretical Study of Al(III)-Catalyzed Conversion of Glyoxal to Glycolic Acid:
Dual Activated 1,2-Hydride Shift Mechanism by Protonated Al(OH)3 Species. T.
Ohshima, Y. Yamamoto, U. Takaki, Y. Inoue, T. Saeki, K. Itou, Y. Maegawa, T. Iwasaki,
K. Mashima, Chem. Commun., 2688-2690 (2009).
DOI: 10.1039/b902729g

72) Development of Environmentally Benign Catalytic Reactions Using
Tetranuclear Zinc Clusters. T. Ohshima, T. Iwasaki, K. Mashima, Journal of Synthetic
Organic Chemistry, Japan, 67, 491-506 (2009).
DOI:10.5059/yukigoseikyokaishi.67.494
71) A Simple, General, and Highly Chemoselective Acetylation of Alcohols Using
Ethyl Acetate as the Acetyl Donor Catalyzed by a Tetranuclear Zinc Cluster. T.
Iwasaki, Y. Maegawa, Y. Hayashi, T. Ohshima, K. Mashima, Synlett, 1659-1663 (2009).
DOI: 10.1055/s-0029-1217335

70) Zinc-Catalyzed Cycloisomerizations. Synthesis of Substituted Furans andFuropyrimidine Nucleosides. A. Sniady, A. Durham, M. S. Morreale, A. Marcinek, S.
Szafert, T. Lis, K. R. Brzezinska, T. Iwasaki, T. Ohshima, K. Mashima, R. Dembinski, J.
Org. Chem., 73, 5881-5889 (2008).
DOI: 10.1021/jo8007995* This paper was highlighted by Synfacts, 4, 1084 (2008).

69) Transesterification of Various Methyl Esters Under Mild Conditions Catalyzed
by Tetranuclear Zinc Cluster. T. Iwasaki, Y. Maegawa, Y. Hayashi, T. Ohshima, K.
Mashima, J. Org. Chem., 73, 5147-5150 (2008).
DOI: 10.1021/jo800625v* This paper was highlighted by Synfacts, 4, 975 (2008).
* This paper was highlighted by Organic Chemistry Portal.
http://www.organic-chemistry.org/abstracts/lit2/174.shtm

68) Catalytic Enantioselective Addition of Terminal Alkynes to Aldehydes:
Preparation of (S)-(–)-1,3-Diphenyl-2-Propyn-1-ol and (S)-(–)-4-Methyl-1-Phenyl-2Pentyn-1,4-Diol. R. Takita, S. Harada, T. Ohshima, S. Matsunaga, M. Shibasaki, Org.
Synth., 85, 118-130 (2008).
DOI:10.1002/0471264229.os085.13

67) Enzyme-like Chemoselective Acylation of Alcohols in the presence of Amines
Catalyzed by a Tetranuclear Zinc Cluster. T. Ohshima, T. Iwasaki, Y. Maegawa, A.
Yoshiyama, K. Mashima, J. Am. Chem. Soc., 130, 2944-2945 (2008).
DOI: 10.1021/ja711349r

* This paper was highlighted by Science (Editor’s Choice), 319, 1163 (2008).

66) Highly Enantio- and s-trans C–C Double Bond Selective Catalytic
Hydrogenation of Cyclic Enones: Alternative Synthesis of (–)-Menthol. T. Ohshima,
H. Tadaoka, K. Hori, N. Sayo, K. Mashima, Chem. Eur. J., 14, 2060-2066 (2008).
DOI: 10.1002/chem.200701505* This paper was highlighted by Nature NEWS & VIEWS), 452, 415-416 (2008).
* This paper was highlighted by Synfacts, 4, 627 (2008).
65) Novel Ir–SYNPHOS® and Ir–DIFLUORPHOS® Catalysts for AsymmetricHydrogenation of Quinolines. C. Deport, M. Buchotte, K. Abecassis, H. Tadaoka, T.
Ayad, T. Ohshima, J.-P. Genet, K. Mashima, V. Ratovelomanana-Vidal, Synlett, 27432747 (2007).
DOI: 10.1055/s-2007-991076

64) Direct Use of Allylic Alcohols for Platinum-Catalyzed Monoallylation of Amines.
M. Utsunomiya, Y. Miyamoto, J. Ipposhi, T. Ohshima, K. Mashima, Org. Lett., 9, 33713374 (2007).
DOI: 10.1021/ol071365s* This paper was highlighted by Organic Chemistry Portal.
http://www.organic-chemistry.org/abstracts/lit1/824.shtm

63) Catalytic Asymmetric Phase-Transfer Michael reaction and Mannich-type
Reaction of Glycine Schiff Base with Chiral Two-Center Organocatalyst. T.
Shibuguchi, A. Kuramochi, T. Ohshima, M. Shibasaki, Chem. Asia. J., 2, 794-801 (2007).
DOI: 10.1002/asia.200700070

62) Short Synthesis of (+)-Cylindricine C and Formal Total Synthesis of (–)Lepadiformine. H. Mihara, T. Shibuguchi, A. Kuramochi, T. Ohshima, M. Shibasaki,
Heterocycles, 72, 421-438 (2007).
DOI: 10.3987/COM-06-S(K)32

61) Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes
with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor. S. Harada, R. Takita, T.
Ohshima, S. Matsunaga, M. Shibasaki, Chem. Commun., 948-950 (2007).
DOI: 10.1039/b614958h60) Catalytic Asymmetric Epoxidation of a,b-Unsaturated Esters Using Chiral
Yttrium-Biaryldiol Complexes. H. Kakei, R. Tsuji, T. Ohshima, H. Morimoto, S.
Matsunaga, M. Shibasaki, Chem. Asian. J., 2, 257-264 (2007).
DOI: 10.1002/asia.200600309

59) Synthesis of the Tricyclic Core of 5a-Capnellenols Using Asymmetric Heck
Reaction–Carbanion Capture Process. W. Itano, T. Ohshima, M. Shibasaki, Synlett,3053-3056 (2006).
DOI: 10.1055/s-2006-951537

58) Hexapalladium cluster: Unique cluster construction reaction of cyclic
Pd3(CNC6H3Me2-2,6)6 and linear [Pd3(CNC6H3Me2-2,6)8]2+. M. Ohashi, J. Yi, D.
Shimizu, T. Yamagata, T. Ohshima, K. Mashima, J. Organomet. Chem., 691, 2457-2464(2006).
DOI: 10.1016/j.jorganchem.2006.01.030

57) Short Synthesis of (+)-Cylindricine C Using Catalytic Asymmetric Michael
Reaction with a Newly Designed Two-Center Organocatalyst. T. Shibuguchi, H.
Mihara, A. Kuramochi, S. Sakuraba, T. Ohshima, M. Shibasaki, Angew. Chem. Int. Ed.,45, 4635-4637 (2006).
DOI: 10.1002/anie.200601722* This paper was highlighted by Synfacts, 2, 951 (2006).

56) Direct Conversion of Esters, Lactones, and Carboxylic Acids to Oxazolines
Catalyzed by Tetranuclear Zinc Cluster. T. Ohshima, T. Iwasaki, K. Mashima, Chem.
Commun., 2711-2713 (2006).
DOI: 10.1039/b605066b55) Asymmetric Alkynylation of Aldehydes Catalyzed by an In(III)/BINOL
Complex. R. Takita, K. Yakura, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc., 127,
13760-13761 (2005).
DOI: 10.1021/ja053946n* This paper was highlighted by Organic Chemistry Portal.
http://www.organic-chemistry.org/abstracts/lit1/184.shtm54) A Topological Isomer of Ferrocene: Theoretical Approach for Transition Metal
Complexes with Conjugated All Trans Cyclodecapentaene. A. Nakamura, T. Ohshima,
K. Mashima, J. Organomet. Chem., 690, 4373-4375 (2005).
DOI: 10.1016/j.jorganchem.2005.06.034

53) Enantio- and diastereoselective construction of vicinal quaternary and tertiarycarbon centers by catalytic Michael reaction of a-substituted b-keto esters to cyclic
enones. K. Majima, S.-y. Tosaki, T. Ohshima, M. Shibasaki, Tetrahedron Lett., 43, 53775381 (2005).
DOI:10.1016/j.tetlet.2005.05.139

52) Dynamic Structural Change of the Self-Assembled Lanthanum Complex
Induced by Lithium Triflate for Direct Catalytic Asymmetric Aldol-Tishchenko
Reaction. Y. Horiuchi, V. Gnanadesikan, T. Ohshima, H. Masu, K. Katagiri, Y. Sei, K.
Yamaguchi, M. Shibasaki, Chem. Eur. J., 11, 5195-5204 (2005).
DOI : 10.1002/chem.200500442

51) Catalytic Asymmetric Epoxidation of a,b-Unsaturated Esters Using an YttriumBiphenyldiol Complex. H. Kakei, R. Tsuji, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc.,
127, 8962-8963 (2005).
DOI: 10.1021/ja052466t* This paper was highlighted by Synfacts, 1, 139 (2005).
* This paper was highlighted by Organic Chemistry Portal.
http://www.organic-chemistry.org/abstracts/lit1/116.shtm50) Formal Total Synthesis of (+)-Wortmannin Using Catalytic Asymmetric
Intramolecular Aldol Condensation Reaction. H. Shigehisa, T. Mizutani, S.-y. Tosaki,
T. Ohshima, M. Shibasaki, Tetrahedron, 61, 5057-5065 (2005).
DOI:10.1016/j.tet.2005.03.038

49) A New Entry in Catalytic Alkynylation of Aldehydes and Ketones: Dual
Activation of Soft Nucleophiles and Hard Electrophiles by an Indium(III) Catalyst.
R. Takita, Y. Fukuta, R. Tsuji, T. Ohshima, M. Shibasaki, Org. Lett., 7, 1363-1366 (2005).
DOI: 10.1021/ol050069h* This paper was highlighted by Science (Editor’s Choice), 308, 19 (2005).

48) Enantio- and Diastereoselective Catalytic Mannich-Type Reaction of a Glycine
Schiff Base Using a Chiral Two-Center Phase-Transfer Catalyst. A. Okada, T.
Shibuguchi, T. Ohshima, H. Masu, K. Yamaguchi, M. Shibasaki, Angew. Chem. Int. Ed.,44, 4564-4567 (2005).
DOI: 10.1002/anie.200500927

47) Dynamic Ligand Exchange of the Lanthanide Complex Leading to the
Structural and Functional Transformation: One-Pot Sequential Catalytic
Asymmetric Epoxidation-Regioselective Epoxide Opening Process. S.-y. Tosaki, R.
Tsuji, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc., 127, 2147-2155 (2005).
DOI: 10.1021/ja043770+

46) Asymmetric Heck Reaction. M. Shibasaki, E. M. Vogl, T. Ohshima, Adv. Synth.
Catal., 346, 1533-1552 (2004).
DOI: 10.1002/adsc.200404203

45) Enantioselective Total Syntheses of Several Bioactive Natural Products Based on
the Development of Practical Asymmetric Catalysis. T. Ohshima, Chem. Pharm. Bull.,52, 1031-1052 (2004).
DOI:10.1248/cpb.52.1031

44) Enantioselective total synthesis of (–)-strychnine: development of a highly
practical catalytic asymmetric carbon–carbon bond formation and domino
cyclization. T. Ohshima, Y. Xu, R. Takita, M. Shibasaki, Tetrahedron, 60, 9569-9588(2004).
DOI:10.1016/j.tet.2004.06.141

43) Direct Catalytic Asymmetric Aldol-Tishchenko Reaction. V. Gnanadesikan, Y.
Horiuchi, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc., 126, 7782-7783 (2004).
DOI: 10.1021/ja047906f* This paper was highlighted by Organic Chemistry Portal.
http://www.organic-chemistry.org/abstracts/literature/219.shtm42) Catalytic asymmetric phase-transfer reactions using tartrate-derived
asymmetric two-center organocatalysts. T. Ohshima, T. Shibuguchi, Y. Fukuta, M.
Shibasaki, Tetrahedron, 60, 7743-7754 (2004).
DOI: 10.1016/j.tet.2004.05.12041) Enantioselective Syntheses and Biological Studies of Aeruginosin 298-A and its
Analogues: Application of Catalytic Asymmetric Phase-Transfer Reaction. Y. Fukuta,

T. Ohshima, V. Gnanadesikan, T. Shibuguchi, T. Nemoto, T. Kisugi, T. Okino, M.
Shibasaki, Proc. Natl. Acad. Sci. USA, 101, 5433-5438 (2004).
DOI: 10.1073/pnas.0307154101

40) Strategy for Enantio- and Diastereoselective Syntheses of All Possible
Stereoisomers of 1,3-Polyol Arrays Based on a Highly Catalyst-Controlled
Epoxidation of a,b-Unsaturated Morpholinyl Amides: Application to Natural
Product Synthesis. S.-y. Tosaki, Y. Horiuchi, N. Nemoto, T. Ohshima, M. Shibasaki,
Chem. Eur. J., 10, 1527-1544 (2004).
DOI : 10.1002/chem.200305709

39) Efficient Synthesis of Chiral a- and b-Hydroxy Amides: Application to Catalytic
Asymmetric Synthesis of (R)-Fluoxetine. H. Kakei, T. Nemoto, T. Ohshima, M.
Shibasaki, Angew. Chem., Int. Ed., 43, 317-420 (2004).
DOI: 10.1002/anie.200352431

38) Catalytic Asymmetric Michael Reaction of b-Keto Esters: Effects of the Linker
Heteroatom in Linked-BINOL. K. Majima, R. Takita, A. Okada, T. Ohshima, M.
Shibasaki, J. Am. Chem. Soc., 125, 15837-15845 (2003).
DOI: 10.1021/ja037635t

37) Enantioselective Syntheses of Aeruginosin 298-A and its Analogs Using Catalytic
Asymmetric Phase-Transfer Reaction and Epoxidation. T. Ohshima, V. Gnanadesikan,
T. Shibuguchi, Y. Fukuta, T. Nemoto, M. Shibasaki, J. Am. Chem. Soc., 125, 11206-11207(2003).
DOI: 10.1021/ja037290e

36) Catalytic asymmetric epoxidation of a,b-unsaturated carboxylic acidimidazolides and amides by lanthanide-BINOL complexes. T. Ohshima, T. Nemoto,S.-y. Tosaki, H. Kakei, V. Gnanadesikan, M. Shibasaki, Tetrahedron, 59, 10485-10497(2003).
DOI: 10.1016/j.tet.2003.06.010

35) Enantioselective total syntheses of (+)-decursin and related natural compounds
using catalytic asymmetric epoxidation of an enone. T. Nemoto, T. Ohshima, M.
Shibasaki, Tetrahedoron, 59, 6889-6897 (2003).
DOI: 10.1016/S0040-4020(03)00861-5

34) Catalytic Asymmetric Synthesis of Both syn- and anti-3,5-Dihydroxy Esters:
Application to 1,3-Polyol/a-Pyrone Natural Product Synthesis. S.-y. Tosaki, T.
Nemoto, T. Ohshima, M. Shibasaki, Org. Lett., 5, 495-498 (2003).
DOI: 10.1021/ol0273708

33) Unique Reactivity of a,b-Unsaturated Carboxylic Acid Imidazolides: Catalytic
Asymmetric Synthesis of a,b-Epoxy Esters and a,b-Epoxy Carboxylic Acid
Derivatives. T. Nemoto, S.-y. Tosaki, T. Ohshima, M. Shibasaki, Chirality, 15, 306-311(2003).
DOI:10.1002/chir.10205

32) Development of new asymmetric two-center catalysts in phase-transfer reactions.
T. Shibuguchi, Y. Fukuta, Y. Akachi, A. Sekine, T. Ohshima, M. Shibasaki, Tetrahedoron
Lett., 43, 9539-9543 (2002).
DOI:10.1016/S0040-4039(02)02416-431) Enantioselective Total Synthesis of (–)-Strychnine Using the Catalytic
Asymmetric Michael Reaction and Tandem Cyclization. T. Ohshima, Y. Xu, R. Takita,
S. Shimizu, D. Zhong, M. Shibasaki, J. Am. Chem. Soc., 124, 14546-14547 (2002).
DOI: 10.1021/ja028457r

30) Catalytic Asymmetric Epoxidation of a,b-Unsaturated Amides: Efficient
Synthesis of b-Aryl a-Hydroxy Amides Using a One Pot Tandem Catalytic
Asymmetric Epoxidation–Pd-Catalyzed Epoxide Opening Process. T. Nemoto, H.
Kakei, V. Gnanadesikan, S.-y. Tosaki, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc., 124,
14544-14545 (2002).
DOI: 10.1021/ja028454e

29) Development of New Asymmetric Reactions Using Rare Earths Containing
Asymmetric Catalysts. M. Shibasaki, M. Kanai, T. Ohshima, T. Nemoto, RARE
EARTHS, 41, 37-42 (2002).
28) Highly enantioselective catalytic Michael reaction of a-substituted malonates
using La-linked-BINOL complex in the presence of HFIP (1,1,1,3,3,3hexafluoroisopropanol). R. Takita, T. Ohshima, M. Shibasaki, Tetrahedoron Lett., 43,4661-4665 (2002).
DOI:10.1016/S0040-4039(02)00882-1

27)

A

practical

large-scale

synthesisofenantiomerically

pure

3-

[bis(methoxycarbonyl)methyl]cyclohexanone via catalytic asymmetric michaelreaction. Y. Xu, K. Ohori, T. Ohshima, M. Shibasaki, Tetrahedoron, 58, 2585-2588(2002).
DOI:10.1016/S0040-4020(02)00141-2

26) An enantioselective formal synthesis of 4-demethoxydaunomycin using thecatalytic asymmetric ring opening reaction of meso-epoxide with p-anisidine. A.
Sekine, T. Ohshima, M. Shibasaki, Tetrahedoron, 58, 75-82 (2002).
DOI:10.1016/S0040-4020(01)01088-2

25) Catalytic Asymmetric Epoxidation of a,b-Unsaturated Carbonyl Compounds. T.
Nemoto, T. Ohshima, M. Shibasaki, Journal of Synthetic Organic Chemistry, Japan, 60,
94-105 (2002).
DOI:10.5059/yukigoseikyokaishi.60.94

24) Linked-BINOL –an Approach towards Practical Asymmetric Multifunctional
Catalysis–. S. Matsunaga, T. Ohshima, M. Shibasaki, Adv. Synth. Catal., 344, 3-15 (2002).
DOI:10.1002/1615-4169(200201)344:1<3::AID-ADSC3>3.0.CO;2-2

23) Highly regioselective synthesis of cyclic enol silyl ethers using ring-closing
metathesis. A. Okada, T. Ohshima, M. Shibasaki, Tetrahedoron Lett., 42, 8023-8027(2001).
DOI:10.1016/S0040-4039(01)01713-0

22) Catalytic Asymmetric Synthesis of a,b-Epoxy Esters, Aldehydes, Amides, andg,d-Epoxy b-Keto Esters: Unique Reactivity of a,b-Unsaturated Carboxylic Acid

Imidazolides. T. Nemoto, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc., 123, 9474-9475(2001).
DOI: 10.1021/ja0164879

21) Direct Catalytic Enantio- and Diastereoselective Aldol Reaction Using a Zn-Znlinked-BINOL Complex: a Practical Synthesis of syn-1,2-Diols. N. Kumagai, S.
Matsunaga, N. Yoshikawa, T. Ohshima, M. Shibasaki, Org. Lett., 3, 1539-1542 (2001).
DOI: 10.1021/ol015878p

20) Direct Catalytic Asymmetric Aldol Reaction: Synthesis of either syn- or antia,b-Dihydroxy Ketones. N. Yoshikawa, N. Kumagai, S. Matsunaga, G. Moll, T.

Ohshima, T. Suzuki, M. Shibasaki, J. Am. Chem. Soc., 123, 2466-2467 (2001).
DOI: 10.1021/ja015580u

19) Catalytic Asymmetric Epoxidation of Enones Using La-BINOL-Triphenylarsine
Oxide Complex: Structural Determination of the Asymmetric Catalyst. T. Nemoto,
T. Ohshima, K. Yamaguchi, M. Shibasaki, J. Am. Chem. Soc., 123, 2725-2732 (2001).
DOI: 10.1021/ja004201e18) Enantioselective total syntheses of novel PKC activator (+)-decursin and its
derivatives using catalytic asymmetric epoxidation of an enone. T. Nemoto, T.
Ohshima, M. Shibasaki, Tetrahedoron Lett., 41, 9569-9574 (2000).
DOI:10.1016/S0040-4039(00)01702-0

17) Immobilization of asymmetric multifunctional catalysts on an insoluble polymer.
S. Matsunaga, T. Ohshima, M. Shibasaki, Tetrahedoron Lett., 41, 8473-8478 (2000).
DOI:10.1016/S0040-4039(00)01486-6

16) Stable, Storable and Reusable Asymmetric Catalyst: a Novel La-linked-BINOL
Complex for Catalytic Asymmetric Michael Reaction. Y. S. Kim, S. Matsunaga, J. Das,
A. Sekine, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc., 122, 6506-6507 (2000).
DOI: 10.1021/ja001036u

15) Total Synthesis of the Immunosuppressant Sanglifehrin A. K. C. Nicolaou, F.
Murphy, S. Barluenga, T. Ohshima, H. Wei, J.-Y. Xu, D. L. F. Gray, O. Baudoin, J. Am.
Chem. Soc., 122, 3830-3838 (2000).
DOI: 10.1021/ja994285v

14) Catalytic Asymmetric Synthesis of 19,20-Dihydroakuammicine. K. Ohori, S.
Shimizu, T. Ohshima, M. Shibasaki, Chirality, 12, 400-403 (2000).
DOI:10.1002/(SICI)1520-636X(2000)12:5/6<400::AID-CHIR18>3.0.CO;2-H

13) An Efficient Method for the Synthesis of Versatile Intermediates Leading to 13Deoxy- and 9,13-Dideoxyphorbols. A. Sekine, N. Kumagai, K. Uotsu, T. Ohshima, M.
Shibasaki, Tetrahedron Lett., 41, 509-513 (2000).
DOI:10.1016/S0040-4039(99)02103-6

12) Total synthesis and Chemical Biology of the Sarcodictyins. K. C. Nicolaou, J.
Pfefferkorn, J.-Y. Xu, N. Winssinger, T. Ohshima, S. Kim, S. Hosokawa, D. Vourloumis,
F. van Delft, T. Li, Chem. Pharm. Bull., 47, 1199-1213 (1999).
DOI:10.1248/cpb.47.1199

11) Total Snthesis of Sanglifehrin A. K. C. Nicolaou, J.-Y. Xu, F. Murphy, S. Barluenga,
B. Olivier, H.-x. Wei, D. L. F. Gray, T. Ohshima, Angew. Chem., Int. Ed., 38, 2447-2451(1999).
DOI:10.1002/(SICI)1521-3773(19990816)38:16<2447::AID-ANIE2447>3.0.CO;2-O

10) Synthesis of the macrocyclic core of sanglifehrin A. K. C. Nicolaou, T. Ohshima,
F. Murphy, S. Barluenga, J.-Y. Xu, N. Winssinger, Chem. Commun., 809-810 (1999).

9) Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial
Sarcodictyin Libraries. K. C. Nicolaou, N. Winssinger, D. Vourloumis, T. Ohshima, S.
Kim, J. Pfefferkorn, J.-Y.; Xu, T. Li, J. Am. Chem. Soc., 120, 10814-1082652 (1998).
DOI: 10.1021/ja9823870

8) Total Synthesis of Eleutherobin and Eleuthosides A and B. K. C. Nicolaou, T.
Ohshima, T.; S. Hosokawa, F. L. van Delft, D. Vourloumis, J.-Y. Xu, J. Pfefferkorn, S.
Kim, J. Am. Chem. Soc., 120, 8674-8680 (1998).
DOI:10.1021/JA9810639

7) Total Synthesis of Sarcodictyins A and B. K. C. Nicolaou, J.-Y. Xu, S. Kim, J.
Pfefferkorn, T. Ohshima, D. Vourloumis, S. Hosokawa, J. Am. Chem. Soc., 120, 86618673 (1998).

DOI:10.1021/JA981062G

6) Synthesis and biological activity of sarcodictyins. K. C. Nicolaou, S. Kim, J.
Pfefferkron, J.-Y. Xu, T. Ohshima, S. Hosokawa, D. Vourloumis, T. Li, Angew. Chem.,
Int. Ed., 37, 1418-1421 (1998).
DOI:10.1002/(SICI)1521-3773(19980605)37:10<1418::AID-ANIE1418>3.0.CO;2-5

5) Total synthesis of eleutherobin. K. C. Nicolaou, F. van Delft, T. Ohshima, D.
Vourloumis, J.-Y. Xu, S. Hosokawa, J. Pfefferkorn, S. Kim, T. Li, Angew. Chem., Int. Ed.
Engl., 36, 2520-2524 (1997).
DOI:10.1002/anie.199725201* This paper was highlighted by C&E News, Nov. 24, 64-65 (1997).

4) Synthesis of the Tricyclic Core of Eleutherobin and Sarcodictyins and Total
Synthesis of Sarcodictyin A. K. C. Nicolaou, J.-Y. Xu, S. Kim, T. Ohshima, S. Hosokawa,

J. Pfefferkorn, J. Am. Chem. Soc., 119, 11353-11354 (1997).
DOI:10.1021/JA973000G

3) Asymmetric Heck Reaction-Carbanion Capture Process. Catalytic Asymmetric
Total Synthesis of (–)-D9(12)-Capnellene. T. Ohshima, K. Kagechika, M. Adachi, M.
Sodeoka, M. Shibasaki, J. Am. Chem. Soc., 118, 7108-7116 (1996).
DOI:10.1021/JA9609359

2) Manganese(III)-based oxidative free-radical reaction of a-allyl-b-keto ester withmolecular oxygen. T. Ohshima, M. Sodeoka, M. Shibasaki, Tetrahedron Lett., 34, 85098512 (1993).
DOI:10.1016/S0040-4039(00)61371-0

1) Asymmetric Heck reaction-anion capture process. A catalytic asymmetricsynthesis of the key intermediates for the capnellenols. K. Kagechika, T. Ohshima, M.
Shibasaki, Tetrahedron, 49, 1773-1782 (1993).
DOI:10.1016/S0040-4020(01)80534-2