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Idents for misc. libs in adobe-flash-release. The Files .Effect of Coartem®, a low-cost artemisinin-based combination therapy
on bacterial and asexual density in Plasmodium falciparum-infected children in Dar es Salaam, Tanzania. To investigate theeffect of Coartem® (artemether-lumefantrine), a low-cost artemisinin-based combination therapy, on asexual parasitaemia andalso on the density of related bacteria in the blood of malaria patients in Dar es Salaam, Tanzania. A randomized controlled trial
using artemether-lumefantrine was conducted in children with uncomplicated Plasmodium falciparum malaria in Dar es Salaam.
Patients were treated with the standard dose of Coartem® (Coartem®; 20 mg artemether and 120 mg lumefantrine, equivalent
to dihydroartemisinin/piperaquine) (Coartem® group) or Coartem® (Coartem® 20 mg artemether + 100 mg lumefantrine;
standard dose) (Coartem® group) for 3 days. The asexual parasitaemia and the density of related bacteria in the blood wereassessed. There were no significant differences in asexual parasitaemia or the density of related bacteria between the Coartem®
and Coartem® groups after treatment at the different time-points. Although prevalence of co-infection with intestinal parasites
in the Coartem® group was increased compared to the control group, no association was found between the asexual parasite
density and the density of related bacteria. This study showed that treatment with Coartem® at a fixed dose of 20 mg
artemether and 120 mg lumefantrine for 3 days results in high cure rates in most of the children with uncomplicated malaria,
and is also associated with a modest increase in bacterial carriage. However, this increase in bacterial carriage is not associatedwith an increased risk of asexual parasitaemia. The side effect profile of Coartem® is likely to be tolerable, and therefore thiscombination may provide a useful option for the treatment of uncomplicated malaria in the future.--- id: version-2.4.0-sequence
title: Sequence sidebar_label: Sequence original_id: sequence --- Use the `Sequ

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