Chariot™ Protein Delivery Reagent Citations
Chariot™
293, Flp-In cells (human, embyronic kidney)
Apaja et al. “Luteinizing Hormone Receptor Ectodomain Splice Variant Misroutes the Full-Length Receptor into a
Subcompartment of the Endoplasmic Reticulum.” (2006) Molecular Biology of the Cell 17(5):2243-2255.
407 cells (human, intestine)
van der Wijk et al. “Increased Vesicle Recycling in Response to Osmotic Cell Swelling.” (2003) Journal of Biological
Chemistry 278(41):40020-40025.
Adrenal Gland slices (mouse)
Chan et al. “Adrenal Chromaffin Cells Exhibit Impaired Granule Trafficking in NCAM Knockout Mice.” (2005) Journalof Neurophysiology 94(2):1037-1047.
AGS cells (human, stomach adenocarcinoma)
Nossa et al. “Activation of the Abundant Nuclear Factor Poly(ADP-ribose) Polymerase-1 by Helicobacter pylori.”(2009) Proc. Natl. Acad. Sci. USA 106(47):19998-20003.
Alveolar cells (mouse, lung)
Aoshiba et al. “Senescence Hypothesis for the Pathogenetic Mechanism of Chronic Obstructive Pulmonary Disease.”(2009) Proceedings of the ATS 6(7):596-601.
Amo (rat and mouse)
Lasbury et al. “Effects of Decreased Calmodulin Protein on the Survival Mechanisms of Alveolar Macrophages during
Pneumocystis Pneumonia.” (2009) Infection and Immunity 77(8):3344-54.
Aortic rings (rat)Lima et al. “O-GlcNAcylation Contributes to Augmented Vascular Reactivity Induced by Endothelin 1.” (2010)
Hypertension 55(1):180-188.
Aortic tissue (rat, primary)
Giachini et al. “Increased Activation of Stromal Interaction Molecule-1/Orai-1 in Aorta From Hypertensive Rats: A
Novel Insight Into Vascular Dysfunction.” (2009) Hypertension 53(2):409-16.
B cells (human, Hodgkin's)
Kashkar et al. “XIAP-mediated Caspase Inhibition in Hodgkin's Lymphoma-derived B Cells.” (2003) Journal of
Experimental Medicine 198(2):341-347.
BAEC (bovine, aortic endothelial cells)
Liu et al. “Dehydroepiandrosterone Protects Vascular Endothelial Cells Against Apoptosis through a Gαi-ProteinDependent Activation of Phosphatidylinositol 3-Kinase/Akt and Regulation of Anti-apoptotic Bcl-2 Expression.”(2007) Endocrinology 148(7):3068-3076.
Bovine Zygote
Rawe et al. “Profilin and Actin-related Proteins Regulate Microfilament Dynamics During Early Mammalian
Embryogenesis.” (2006) Human Reproduction 21(5):1143-1153.

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Brain and fetal tissue (mouse, primary)
Tagami et al. “Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1.” (2008)
Molecular and Cellular Biology 28(1):165-176.
C2C12 cells (mouse, muscle myoblast)
Tassa et al. “Class III Phosphoinositide 3-Kinase-Beclin1 Complex Mediates the Amino Acid-dependent Regulation ofAutophagy in C2C12 Myotubes.” (2003) Biochemical Journal 376(Pt. 3):577-586.
Zhang et al. “Effect of Cyclic Stretch on β1D-Integrin Expression and Activation of FAK and RhoA.” (2007) Am. J.
Physiol. Cell Physiol. 292(6):C2057-C2069.
Cardiomyocytes (rat)Mizukami et al. “ERK1/2 Regulates Intracellular ATP Levels through α-Enolase Expression in Cardiomyocytes exposed
to Ischemic Hypoxia and Reoxygenation.” (2004) Journal of Biological Chemistry 279(48):50120-50131.
Chariot Profile
Boguslavsky et al. “Delivering DNA with Transfection Perfection.” (2003) Genomics & Proteomics 3(2):38-40.
CHO cells (Chinese hamster, ovary)
Lee et al. “The Hexapeptide Inhibitor of Galbeta 1,3GalNAc-specific alpha 2,3-Sialyltransferase as a Generic Inhibitorof Sialyltransferases.” (2002) Journal of Biological Chemistry 277(51):49341-49351.
Chromaffin cells (mouse, adrenal medullae primary)
Doreian et al. “Cortical F-Actin, the Exocytic Mode, and Neuropeptide Release in Mouse Chromaffin Cells Is
Regulated by Myristoylated Alanine-rich C-Kinase Substrate and Myosin II.” (2009) Molecular Biology of the Cell 20(13):3142-3154.
COS-7 cells (monkey, kidney)
Zhang et al. “Homeodomain-interacting Protein Kinase-2 Mediates CtBP Phosphorylation and Degradation in UVtriggered Apoptosis.” (2005) Proc. Natl. Acad. Sci. USA 102(8):2802-2807.
CV-1 cells (monkey, kidney)
Buster et al. “Katanin Inhibition Prevents the Redistribution of γ-Tubulin at Mitosis.” (2002) Journal of Cell Science
115(15):1083-1092.
DRG axons (rat)
Heerssen et al. “Dynein Motors Transport Activated Trks to Promote Survival of Target-dependent Neurons.” (2004)
Nature Neuroscience 7(6):596-604.
Embryo Retina (chicken)
Gehler et al. “Brain-Derived Neutrophic Factor Regulation of Retinal Growth Cone Filopodial Dynamics Is Mediatedthrough Actin Depolymerizing Factor/Cofilin.” (2004) Journal of Neuroscience 24(47):10741-10749.
Eosinophils (human)
Cen et al. “Identification of UNC119 as a Novel Activator of SRC-type Tyrosine Kinases.” (2003) Journal of Biological
Chemistry 278(10):8837-8845.
Gingival fibroblasts (human, primary)Black et al. “Transforming Growth Factor-β1 (TGFβ1) Stimulates Connective Tissue Growth Factor (CCN2/CTGF)
Expression in Human Gingival Fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent Mechanism: StatinsWith Forskolin Block TGFβ1-Induced CCN2/CTGF Expression.” (2008) Journal of Biological Chemistry 283(16):10835-40847.

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H295r cells (human, adrenocortical)
Romero et al. “Angiotensin II-Mediated Protein Kinase D Activation Stimulates Aldosterone and Cortisol Secretion in
H295R Human Adrenocortical Cells.” (2006) Endocrinology 147(12):6046-6055.
HA-13 cells (hybridoma)
Cheriyath et al. “c-Src-dependent Transcriptional Activation of TFII-I.” (2002) Journal of Biological Chemistry 277(5):22798-22805.
HaCaT cells (human, adult keratinocytes) and NHK cells (human, normal keratinocytes)
Sakaguchi et al. “S100C/A11 is a Key Mediator of Ca2+-induced Growth Inhibition of Human Epidermal Keratinocytes.”(2003) Journal of Cell Biology 163(4):825-835.
HEK293 cells (human, embryonic kidney)
Forneris et al. “A Highly Specific Mechanism of Histone H3-K4 Recognition by Histone Demethylase LSD1.” (2006)
Journal of Biological Chemistry 281(46):35289-25295.
Lerner-Marmarosh et al. “Regulation of TNF-α-activated PKC-ζ Signaling by the Human Biliverdin Reductase:
Identification of Activating and Inhibitory Domains of the Reductase.” (2007) The FASEB Journal 21(14):3949-3962.
HEK293 cells (human, embryonic kidney) and Hippocampal neurons
Li et al. “G Protein β2 Subunit Derived Peptides for Inhibition and Induction of G Protein Pathways.” (2005) Journalof Biological Chemistry 280(25):23945-23959.
HeLa cells (human, cervical cancer)
Manthey et al. “Nbs1 Mediates ATR-dependent RPA Hyperphosphorylation Following Replication-Fork Stall andCollapse.” (2007) Journal of Cell Science 120(Pt. 23):4221-4229.
Sato et al. “Probing the Chromosome 9p21 Region Susceptible to DNA Double-strand Breaks in Human Cells In Vivo
by Restriction Enzyme Transfer.” (2005) Oncogene 24(40):6108-6118.
HeLa cells (human, cervical cancer) and HEK293 cells (human, embryonic kidney)
Kim et al. “Importin-β Mediates Cdc7 Nuclear Import by Binding to the Kinase Insert II Domain, which can be
Antagonized by Importin-α.” (2006) Journal of Biological Chemistry 281(17):12041-12049.
Hep G2 cells (human, hepatocellular carcinoma)
Alshatwi et al. “Nuclear Accumulations of p53 and Mdm2 Are Accompanied by Reductions in c-Abl and p300 in Zincdepleted Human Hepatoblastoma Cells.” (2006) Exp. Biol. Med. 231(5):611-618.
Hepatocytes (mouse, primary)
Bardag-Gorce et al. “The Mechanism of Cytokeratin Aggresome Formation: the Role of Mutant Ubiquitin (UBB+1).”(2003) Exp. & Mol. Pathology 74(2):160-167.
Hippocampal neuronal cultures (rat)Blair et al. “Epileptogenesis Causes Acute and Chronic Increases in GABA-A Receptor Endocytosis That Contributes tothe Induction and Maintenance of Seizures in the Hippocampal Culture Model of Acquired Epilepsy.” (2004) Journalof Pharmacology Exp. Ther. 310(3):871-880.
Hippocampal neurons (primary)Viviani et al. “IL-1β Released by gp120 Drives Neural Death Through Tyrosine Phosphorylation and Trafficking of
NMDA Receptors.” (2006) Journal of Biological Chemistry 281(40):30212-30222.
Hippocampal neurons (rat, primary)
MacAskill et al. “Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at
Synapses.” (2009) Neuron 61(4):541-555.
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HT-29 cells (human, colon adenocarcinoma)
Yang et al. “Phosphorylation of P68 RNA Helicase plays a Role in PDGF-induced Cell Proliferation by Up-regulating
Cyclin D1 and c-Myc Expression.” (2007) Journal of Biological Chemistry 282(23):16811-16819.
HT1080 cells (human, fibrosarcoma)
Minogue et al. “Phosphatidylinositol 4-kinase is Required for Endosomal Trafficking and Degradation of the EGF
Receptor.” (2006) Journal of Cell Science 119(Pt. 3):571-581.
INS-1 cells (rat, insulinoma)
Fu et al. “Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways andPrevents Insulin-Deficient Diabetes in Mice.” (2010) Endocrinology 151(7):3026-3037.
Isolated Resistance Arteries
Keller et al. “Sphongosine Kinase Functionally Links Elevated Transmural Pressure and Increased Reactive Oxygen
Species Formation in Resistance Arteries.” (2006) The FASEB Journal 20(6):702-704.
Jurkat cells (human, T cell lymphoblast-like)
Gorska et al. “Unc119, a Novel Activator of Lck/Fyn, Is Essential for T Cell Activation.” (2004) Journal of Experimental
Medicine 199(3):369-379.
Kidney cultures (mouse, embryonic)
Sorenson et al. “Interaction of bcl-2 with Paxillin through Its BH4 Domain Is Important during Ureteric Bud
Branching.” (2004) Journal of Biological Chemistry 279(12):11368-11374.
KO macrophages
Garnon et al. “Fragile X-related Protein FXR1P Regulates Proinflammatory Cytokine Tumor Necorsis Factor Expression
at the Post-transcriptional Level.” (2005) Journal of Biological Chemistry 280(7):5750-5763.
L929 cells (mouse, fibrosarcoma)
Park et al. “The Cell-Penetrating Peptide, Pep-1, has Activity Against Intracellular Chlamydial Growth but Not
Extracellular Forms of Chlamydia trachomatis.” (2009) Journal of Antimicrobial Chemotherapy 63(1):115-123.
LEW cells (rat (Lewis), fibroblast skin primary)Planz et al. “Borna Disease Virus Nucleoprotein Interacts with the Cdc2-Cyclin B1 Complex.” (2003) Journal of
Virology 77(20):11186-11192.
LLC-PK1 cells (pig, renal epithelial)
Liu et al. “Endoplasmic Reticulum Stress-Associated Caspase 12 Mediates Cisplatin-Induced LLC-PK1 Cell Apoptosis.”(2005) J. Am. Soc. Nephrol. 16(7):1985-1992.
LLC-PK1 cells (porcine, renal epithelial)
Ikari et al. “Up-regulation of Sodium-dependent Glucose Transporter by Interaction with Heat Shock Protein 70.”
(2002) Journal of Biological Chemistry 277(36):33338-33343.
LNCaP cells (human, prostatic carcinoma), NbE cells (rat, prostatic epithelium) and COS cells (monkey, kidney) cells
Zhou et al. “Characterization of a Novel Negative Regular (DOC-2/DAB2) of c-Src in Normal Prostatic Epithelium andCancer.” (2003) Journal of Biological Chemistry 278(9):6936-6941.
Lung in vivo (mouse, intratracheally) and alveolar epithelial cells (mouse, primary-in vitro)
Aoshiba et al. “Alveolar Wall Apoptosis Causes Lung Destruction and Emphysematous Changes.” (2003) Am. J. Respir.
Cell Mol. Biol. 28(5):555-562.

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MCF-7 cells (human, breast carcinoma)
Sebbagh et al. “Direct Cleavage of ROCK II by Granzyme B Induces Target Cell Membrane Blebbing in a Caspaseindependent Manner.” (2005) Journal of Experimental Medicine 201(3):465-471.
Lee et al. “Astrocyte Elevated Gene-1 (AEG-1) Is a Target Gene of Oncogenic ha-ras Requiring Phosphatidylinositol 3Kinase and c-Myc.” (2006) Proc. Natl. Acad. Sci. USA 103(46):17390-17395.
MCF-7/ADR cells (human, breast carcinoma)
Lee et al. “The Nucleoside Analog Sangivamycin Induces Apoptotic Cell Death in Breast Carcinoma
MCF7/Adriamycin-resistant Cells via Protein Kinase Cδ and JNK Activation.” (2007) Journal of Biological Chemistry282(20):15271-15283.
MDA-MB-231 cells (human, breast adenocarcinoma)
Pratt et al. “Activation of the EphA2 Tyrosine Kinase Stimulates the MAP/ERK Kinase Signaling Cascade.” (2002)
Oncogene 21(50):7690-7699.
MEF cells (mouse, embryonic fibroblast)
Bonzon et al. “Caspase-2-induced Apoptosis Requires Bid Cleavage: A Physiological Role for Bid in Heat Shockinduced Death.” (2006) Molecular Biology of the Cell 17(5):2150-2157.
Chipuk et al. “Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis.”(2004) Science 303(5660):1010-1014.
MGC80-3, HeLa cells (human, cervical cancer) and NIH-3T3 cells (mouse, fibroblast)
Lin et al. “RXRα Acts As a Carrier for TR3 Nuclear Export in a 9-cis Retinoic Acid-dependent Manner in Gastric Cancer
Cells.” (2004) Journal of Cell Science 117(Pt. 23):5609-5621.
Monocytes (human) and H1299 (human, non-small cell lung cancer)
Tang et al. “p53 Short Peptide (p53pep164) Regulates Lipopolysaccharide-Induced Tumor Necrosis Factor-α
Factor/Cytokine Expression.” (2007) Cancer Research 67(3):1308-1316.
Motor neurons (rat, embryo)
Ye et al. “Prevention of Peroxynitrite-induced Apoptosis of Motor Neurons and PC12 Cells by Tyrosine-containing
Peptides.” (2007) Journal of Biological Chemistry 282(9):6324-6337.
Mouse Embryonic Cells (mouse, primary)
Bayir et al. “Peroxidase Mechanism of Lipid-dependent Cross-linking of Synuclein with Cytochrome c – Protection
Against Apoptosis Versus Delayed Oxidative Stress in Parkinson Disease.” (2009) Journal of Biological Chemistry 284(23):15951-15969.
Muscle tissue (mouse)
Jevsek et al. “CD24 is Expressed by Myofiber Synaptic Nuclei and Regulates Synaptic Transmission.” (2006) Proc. Natl.
Acad. Sci. USA 103(16):6374-6379.
NbE cells (rat, nontumorigenic prostatic epithelial)
Zhou et al. “The Inhibitory Role of DOC-2/DAB2 in Growth Factor Receptor-mediated Signal Cascade.” (2001) Journalof Biological Chemistry 276(30):27793-27798.
NCI-H295R cells (human, adrenal corticocarcinoma)
Pandey et al. “Protein Phosphatase 2A and Phosphoprotein SET Regulate Androgen Production by P450c17.” (2003)
Journal of Biological Chemistry 278(5):2837-2844.
Sugawara et al. “CREM Confers cAMP Responsiveness in Human Steroidogenic Acute Regulatory Protein Expression in
NCI-H295R Cells Rather Than SF-1/Ad4BP.” (2006) Journal of Endocrinology 191(1):327-337.

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Neocortical neurons (mouse, embryo)
Ma et al. “Toll-like Receptor 8 Functions As a Negative Regulator of Neurite Outgrowth and Inducer of Neuronal
Apoptosis.” (2006) Journal of Cell Biology 175(2):209-215.
Neuronal cells (DRG axons)
Gallo et al. “Actin Turnover Is Required to Prevent Axon Retraction Driven by Endogenous Actomyosin Contractility.”(2002) Journal of Cell Biology 158(7):1219-1228.
Neuronal cells (growth cones)
Jurney et al. “Rac1-Mediated Endocytosis during Ephrin-A2- and Semaphorin 3A-Induced Growth Cone Collapse.”(2002) Journal of Neuroscience 22(14):6019-6028.
Neuronal cells (mouse, DRG and chick, E9 ganglions)
Coulpier et al. “Coordinated Activation of Autophosphorylation Sites in the RET Receptor Tyrosine Kinase.” (2002)
Journal of Biological Chemistry 277(3):1991-1999.
NIH-3T3 cells, Ron (mouse, fibroblast)
Yokoyama et al. “The C Terminus of RON Tyrosine Kinase Plays an Autoinhibitory Role.” (2005) Journal of Biological
Chemistry 280(10):8893-8900.
NRK cells (rat, normal kidney)
Tisdale et al. “Glyceraldehyde-3-phosphate Dehydrogenase Is Phosphorylated by Protein Kinase C and Plays a Role in
Microtubule Dynamics in the Early Secretory Pathway.” (2002) Journal of Biological Chemistry 277(5):3334-3341.
Oligodendrocytes (mouse)
Kippert et al. “Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane
Specialization in Oligodendroglial Cells.” (2007) Journal of Neuroscience 27(13):3560-3570.
Osteoclasts (mouse)
Nandan Sahu et al. “Association of Leupaxin with Src in Osteoclasts.” (2007) Am. J. Physiol. Cell Physiol. 292(1):C581C590.
PAEC cells (porcine, aortic endothelial cells)
Cioffi et al. “Activation of the Endothelial Store-Operated ISOC Ca2+ Channel Requires Interaction of Protein 4.1 with
TRPC4.” (2005) Circulation Research 97(11):1164-1172.
PBMC (human, peripheral blood mononuclear cells from MCL patients)
Roue et al. “Bendamustine Is Effective in p53-Deficient B-Cell Neoplasms and Requires Oxidative Stress and CaspaseIndependent Signaling.” (2008) Clinical Cancer Research 14(21):6907-6915.
PC-12 cells (rat, pheochromocytoma)
Limpert et al. “Nerve Growth Factor Stimulates the Concentration of TrkA within Lipid Rafts and Extracellular SignalRegulated Kinase Activation through c-Cbl-Associated Protein.” (2007) Molecular and Cellular Biology 27(16):5686-5698.
Photoreceptor cells (mouse)
Koulen et al. “Interaction Between mGluR8 and Calcium Channels in Photoreceptors is Sensitive to Pertussis Toxin
and Occurs via G Protein βγ Subunit Signaling.” (2005) Investigative Ophth. & Visual Sci. 46(1):287-291.
Plant cells
Wu et al. “Direct Delivery of Bacterial Avirulence Proteins Into Resistant Arabidopsis Protoplasts Leads toHypersensitive Cell Death.” (2002) The Plant Journal 33(1):131-137.

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Pulmonary artery cells (feline, smooth muscle, primary)
Madden et al. “Telokin Expression and the Effect of Hypoxia on Its Phosphorylation Status in Smooth Muscle Cells
from Small and Large Pulmonary Arteries.” (2008) Am. J. Physiol. Lung Cell Mol. Physiol. 294(6):L1166-L1173.
Rat lung tissue (in vivo)
Maron et al. “PKA Delivery to the Distal Lung Airspace Increases Alveolar Liquid Clearance after Isoproterenolinduced Alveolar Epithelial PKA Desensitization.” (2005) Am. J. Physiol. Lung Cell Mol. Physiol. 289(2):349-354.
Review article
Sebbage et al. “Cell-penetrating Peptides and Their Therapeutic Applications.” (2009) Bioscience Horizions 2(1):64-72.
Review article: describes Pep-1 (Chariot): HS-68 (human, foreskin fibroblast), NIH 3T3 (mouse, embryonic fibroblast),
293 (human, kidney) and COS-7 cells (African Green Monkey, kidney)
Morris et al. “A Peptide Carrier for the Delivery of Biologically Active Proteins Into Mammalian Cells.” (2001) Nature
Biotechnology 19(12):1173-1176.
SCC-61 cells (human, squamous carcinoma), SQ-20B cells (human, head and neck cancer) and MEF (mouse, embryonic
fibroblasts)
Taneja et al. “Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy.” (2004)
Journal of Biological Chemistry 279(3):2273-2280.
SH-SY5Y cells (human, neuroblastoma)
Mollereau et al. “Neuropeptide FF (NPFF) Analogs Functionally Antagonize Opioid Activities in NPFF2 ReceptorTransfected SH-SY5Y Neuroblastoma Cells.” (2005) Molecular Pharmacology 67(3):965-975.
SIGC (rat, spontaneously immortalized granulosa cells)
Peluso et al. “Basic Fibroblast Growth Factor Maintains Calcium Homeostasis and Granulosa Cell Viability by
Stimulating Calcium Efflux via a PKCδ-Dependent Pathway.” (2001) Endocrinology 142(10):4203-4211.
SK-N-SH cells (human, neuroblastoma) and U2 OS cells (human, osteosarcoma)
Eskiw et al. “Chromatin Contributes to Structural Integrity of Promyelocytic Leukemia Bodies through a SUMO-1independent Mechanism.” (2004) Journal of Biological Chemistry 279(10):9577-9585.
Spleen cells (mouse)
Arita et al. “Stereochemical Assignment, Antiinflammatory Properties, and Receptor for the Omega-3 Lipid Mediator
Resolvin E1.” (2005) Journal of Experimental Medicine 201(5):713-722.
THP-1 cells (human, leukemia)
Fragaki et al. “A Novel Leishmania Infantum Nuclear Phosphoprotein Lepp12 Which Stimulates IL1-beta Synthesis in
THP-1 Transfectants.” (2003) BMC Microbiology 3(7):Online.
Tang et al. “Identification and Functional Characterization of a Novel Binding Site on TNF-α Promoter.” (2003) Proc.
Natl. Acad. Sci. USA 100(6):4096-4101.
Vero cells (African Green Monkey, kidney epithelial)
Morinaga et al. “Two Distinct Cytotoxic Activities of Subtilase Cytotoxin Produced by Shiga Toxigenic Escherichia
Coli.” (2007) Infection and Immunity 75(1):488-496.
VSMC (rat, vascular smooth muscle cells)
Taniyama et al. “Role of p38 MAPK and MAPKAPK-2 in Angiotensin II-induced AKT Activation in Vascular SmoothMuscle Cells.” (2004) Am. J. Physiol. Cell Physiol. 287(2):C494-C499.

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WEHI7.2 (mouse lymphocytic leukemia cells)
Harr et al. “Glucocorticoid-mediated Inhibition of Lck Modulates the Pattern of T Cell Receptor-induced Calcium
Signals by Down-regulating Inositol 1,4,5-Trisphosphate Receptors.” (2009) Journal of Biological Chemistry 284(46):31860-31871.
Zygotes pronucleate-stage (bovine and rhesus monkey)
Payne et al. “Preferentially Localized Dynein and Perinuclear Dynactin Associate With Nuclear Pore Complex Proteins
to Mediate Genomic Union During Mammalian Fertilization.” (2003) Journal of Cell Science 116(Pt. 1):4727-4738.

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