5. Details and Areas of Research of Faculty Members at Graduate School of Biomedical Sciences
Doctoral Courses [Four years (Department of Medical and Dental Sciences, Infection Research, Life Sciences and Radiation Research,
Division of Advanced Preventive Medical Sciences)]①

Areas of Research in Department of Medical and Dental Sciences

Area of Research

Professor, etc.

Macroscopic
Anatomy

TAKAMURA Keiko(Professor)
MURAI Kiyohito(Senior Assistant Professor)

Histology andCell Biology

AKAZAWA Yuko
(Professor)
SHIBATA Yasuaki(Associate Professor)
MATSUMOTO Gen(Senior Assistant Professor)

Oral Anatomy
and Dental
Anthropology

OYAMADA Jyoichi(Associate Professor)

Cell Biology

MATSUSHITA Yuki
(Associate Professor)

Physiology ofVisceral Function
and Body Fluid
Biochemistry

Oncology

INOUE Tsuyoshi(Professor)
ITO Takashi(Professor)

IKEDA Hiroaki(Professor)

Molecular andGenomic
Biomedicine

MASUTANI Mitsuko(Professor)

Oral ChronoPhysiology

NAKAMURA Wataru(Professor)

Pharmacology

ARUGA Jun
(Professor)

DentalPharmacology

TSUKUBA Takayuki(Professor)

Pathology

OKANO Shinji(Professor)

Pathology

MORI Ryoichi(Associate Professor)

Pathology
Informatics

FUKUOKA Junya(Professor)

Details of main research work
① Microstructural analysis of bone tissue② 3D structural analysis and finite element analysis of CT images of bones③ Research into functional adaptation of motor organs from the perspective of skeletal microevolution among Japanese people④ Research into gene polymorphism in skeletal/joint structure⑤ Research on human clinical anatomy⑥ Anthropological research into skeletal transformation in archeological remains excavated in western Japan⑦ Analysis of molecular mechanism of neuronal aging① Mitochondiral dysfunction, ER stress, and DNA damage response in gastroenterology and hepatology diseases② AI-assisted fibrosis anaysis and spatial prolifing to predict patient outcome③ Epigenetic regulation of germ cell differentiation④ Role of Wnt/b-catenin signaling-related molecules on juvenile development and poor prognosis of hepatocellular carcinoma⑤ Molecular mechanisms of protein aggregates by selective autophagy⑥ Degradation mechanisms of Tau in Alzheimer's diseases⑦ Novel drug discovery for neurodegenerative diseases① Dental anthropological study of the ancient Japanese② Dental anthropological study of the ancient Chinese③ Dental pathological study of the ancient people④ Anatomical study of head and neck
① Cellular dynamics of bone and tooth stem cells② The mechanism of bone regeneration based on the skeletal stem cells③ Cancer and skeletal stem cells④ Discovery of novel biological sciences by the interdisciplinary approach① Elucidation of the pathophysiology of kidney diseases and development of treatment methods② Anti-inflammatory and organ protection mechanisms through the nervous-immune systems③ Atherosclerosis progression mechanism① Mechanisms of DNA higher-order structure formation in the nucleus② Mechanisms of Estrogen receptor-induced gene activation③ Post-translational histone modification and structural changes of chromatin④ ES cell differentiation and structural changes of chromatin① Development of novel immuo cell therapy for cancer patients② Development of novel gene therapy for cancer patients③ Translational research of novel immuno-therapy for cancer patients④ Development of novel transplantation therapy with allogeneic cells⑤ Research into T cell functionality① Oncology and drug development based on molecular and quantum medical science② Optimization of radiotherapy and radioprotection based on molecular and quantum medical science and radiation biology③ Biochemistry and molecular epidemiology on environmental stress biomarkers based on molecular and quantum medical science④ Biochemistry and molecular epidemiology on disease biomarkers based on molecular and quantum medical science① Circadian regulation of Physiological Functions② Neural mechanism in the Suprachiasmatic nucleus; internal circadian clock③ Age related decline in physiological rhythms① Molecular function and physiological role of synapse organizer proteins② Function and pathophysiology of blood-brain-barrier③ Analysis of pathological conditions and development of therapeutic strategies in neurological disorders④ Wiring mechanism of neural circuit and its regulation by diffuse modulatory system① Functions and pathological condition of endo-lysosomal protease② Molecular biological research into endosome and lysosome systems③ Cellular biological research into osteoclast-induced bone resorption mechanisms④ Research into protease in bacteria pathogenic in gum disease
Pathobiological analysis for carcinogenesis and progression of hepato-pancreato-biliary cancer and development of new therapeutic①
drug and biologics
Identification of tumor-agonistic dysbiosis of oral and gut microbiota in carcinogenesis and progression of cancer and elucidation of②
the mechanism③ Pathological assessment of rejection of composite transplantation and elucidation of the mechanism④ Pathobiological analysis of medication-related osteonecrosis of the jaw⑤ Pathobiological analysis of cancer immunotherapy and development of new therapeutic drug and biologics⑥ Elucidation of western medical mechanism of Kampo medicine treatment effects in cancer-burden patients① Investigating the molecular mechanisms of cutaneous wound healing and scar formation② Developing nucleic acid drugs and compounds that contribute to tissue repair③ Molecular biological studies of the extracellular matrix.
④ Functional analysis of wound inflammation and repair-related genes in aging① Standardization of pathological diagnosis using digital technology② Clinico-pathological study of lung diseases (neoplastic and non-neoplastic)③ Image analysis using artificial intelligence34

Area of Research

Professor, etc.

Oral Pathology

FUJITA Shuichi(Associate Professor)

Dental andBiomedical
Materials Science

WATANABE Ikuya(Professor)

Molecular Bone
Biology

ITO Kosei(Professor)

Forensic
Pathology and
Science

IKEMATSU Kazuya(Professor)

Clinical
Epidemiology

SATO Izumi(Professor)

Comparative
MedicineOHSAWA Kazutaka(Professor)

Biomedical
Models

KOBAYASHI Atsushi(Professor)

Functional
Genomics

KISHINO Tatsuya(Associate Professor)

Details of main research work
① Microenvironment of oral squamous cell carcinoma② Functional analysis on DKK3 gene in head and neck squamous cell carcinoma③ Role of Wnt signaling in bone homeostasis① Development of low-elasticity, highly corrosion-resistant titanium alloy for bone replacement material② Optical characteristics of all-ceramic repair porcelain③ Cellular suitability evaluation of biomaterials for dental or biological implant④ Abrasion resistance evaluation of metallic biomaterial⑤ Controlled drug-release system for dental materials① Differentiation, proliferation and tumorigenesis of mesenchymal stem cells② Functional analysis of oncogenes and anti-oncogenes using gene targeted mice
③ Molecular analysis of tumor metastasis using gene targeted mice
① Forensic pathology② Child abuse and neglect③ Forensic molecular pathology④ Forensic genetics⑤ Metabolic Autopsy① Clinical epidemiological study using a large-scale medical database② Research of pharmacoepidemiology using a large-scale medical database① Research of infectious desease in laboratory animals② Research of human infectious diseases from laboratory animals③ Research of infection prevention of laboratory animals① Elucidation of the mechanisms of prion disease development② Establishment of the animal models for spontaneous prion disease③ Elucidation of the common mechanisms of formation and transmission of misfolded proteins① Molecular analysis of genomic imprinting② Clarification of establishment of epigenetics in early embryos and neurons③ Production and analysis of model mice of epigenetics diseases④ Functional analysis of responsible genes of diseases with mental retardation

Forensic Dental
Science
Frontier Oral
Science

KADOWAKI Tomoko(Professor)

Oral Health

SOUTOME Sakiko(Associate Professor)

Ophthalmology
and Visual
Sciences

OISHI Akio
(Associate Professor)

Otolaryngology Head and Neck
Surgery

KUMAI Yoshihiko(Professor)

Neurosurgery

MATSUO Takayuki(Professor)

Anesthesiology
and Intensive
Care Medicine

HARA Tetsuya(Professor)

Cardiovascular
Surgery

MIURA Takashi(Professor)

Urology

IMAMURA Ryoichi(Professor)① Molecular and biological research on the mechanisms of progression and persistence of inflammatory diseases② Analyses and regulation of causative inflammatory factors③ Study on the maintenance and disorder of homeostasis system, focusing on proteolytic mechanisms① The cohort study on periodontal disease and arterial sclerosis, diabetes and other systemic health② Clinical study of perioperative oral management③ The study of medication-Related Osteonecrosis of the jaw④ Community oral health activities and their evaluation① Research into macular disease and its treatment methods② Research into anatomy and function of the vitreous body
③ Basic and Clinical research on retinal and choroidal circulation④ Development of new operating methods on the vitreous body
⑤ Research and clinical practice relating to the treatment of diabetic retinopathy⑥ Basic and clinical research on exfoliation glaucoma⑦ Epidemiological research and treatment on HTLV-1 associated uveitis① Development of the innovative treatment for the radiation induced vocal fold scar in head and neck cancer patients② Development of the innovative treatment for the aspiration caused by sarcopenia in elder patients③ Development of the innovative treatment for the aspiration induced by irradiation in head and neck cancer patients④ Analysis of the expression of the 53BP1 in meso-pharyngeal cancer patients⑤ Proto-oncogene mutations in middle ear cholesteatoma contribute to its pathogenesis⑥ Development of an new screening system for newborn hearing-impaired children① Technological development of skull base surgery② Development of support system for brain tumor surgery③ Research into neuroendoscopic surgery④ Research into radiobiological effect for brain tumor after stereotactic irradiation⑤ Analysis of mechanism in blood brain barrier① Pathology of acute heart failure and its control② Control of molecular pathology in ischemia/reperfusion injury③ Intestinal pathology of septic shock④ Neural mechanism of chronic pain and its control① Research into valvuloplasty② Research into video-assisted minimally invasive cardiac surgery③ Research into microscopic bypass surgery with permanent graft patency④ Robotic surgery⑤ Research into aortic root anatomy in patients with aortic regurgitation using 4D-CT⑥ Research into the surgical anatomy of mitral valve complex in hypertrophic obstructive cardiomyopathy⑦ Research into surgery for secondary tricuspid regurgitation due to leaflet tethering① Research into biomarkers for early diagnosis of antibody-related rejection after kidney transplantation② Research into the efficacy of the new generation antioxidants for interstitial fibrosis after kidney transplantation③ Interaction between regulatory T cells and natural killer cells in microenvironment of renal cell carcinoma④ Elucidation of the pathological significance of the Hippo pathway in bladder cancer⑤ Primary Aldosteronism：Research into Predicting Hypertension Outcomes Following Adrenalectomy

35

Area of Research

Professor, etc.

SurgicalOncology

MATSUMOTO Keitaro(Associate Professor)

Surgery

EGUCHI Susumu(Professor)

Obstetrics andGynecology

MIURA Kiyonori(Professor）

Orthopaedic
Surgery

OSAKI Makoto(Professor)

Plastic andReconstructive
Surgery

KASHIYAMA Kazuya(Associate Professor)

Neuropsychiatry

KUMAZAKI Hirokazu(Professor)

Glocal Mental
Health Science

OZAWA Hiroki(Professor)

Dermatology

MUROTA Hiroyuki(Professor)

Cardiovascular
Medicine

MAEMURA Koji
(Professor)

Gastroenterology
and Hepatology

MIYAAKI Hisamitsu(Associate Professor)

Details of main research work
① Research into molecular biology of lung, gastrointestinal, thyroid and breast cancer② Research into environmental factors and genetic mutations in lung, gastrointestinal, thyroid, and breast cancer③ Research into novel Therapeutic Methods for Intractable Diseases of the Respiratory and Gastrointestinal Tracts④ Research into respiratory function preserving surgery and reconstructive surgery⑤ Research into lung transplantation and organ preservation⑥ Research into regenerative medicine in the respiratory and gastrointestinal tracts⑦ Development of new medical devices by medical-engineering⑧ Research into perioperative infection⑨ Research into minimally invasive surgery and automated robotic surgery① Research into digestive organ transplantation (liver, pancreas, islets, small bowel, etc.)② Research into digestive organ regenerative medicine (digestive tract, liver, pancreas, islets, etc.)③ Research into digestive organ cancer (digestive tract, liver, pancreas, biliary tract)④ Research into laparoscopic and robot and AI surgery⑤ Research into thyroid and breast surgery and cancer⑥ Research into development of new strategy for pediatric surgery⑦ Research into immunotherapy for malignant tumors and organ transplantation① Research into Placental and Fetal Functions② Research into Clinical Significance of Perinatal Stem Cell in Obstetrics and Gynecology③ Research into Mother-to-Child Infections④ Research into Reproductive Medicine⑤ Research into Gynecologic Oncology⑥ Research into Women's Healthcare⑦ Research into Laparoscopic and Robot Surgery in Obstetrics and Gynecology① Bone metabolism research using bone marrow adipocyte② Epidemiological research into osteoarthritis, osteoporosis, dialytic spondylosis③ Research into biofilms④ Research into clinical application of photocatalysts in antibacterial material development⑤ Bone structure and mechanical analysis using CT and MRI⑥ Research into preventing sports injury⑦ Analysis of joint kinematics⑧ Pathological analysis of osteonecrosis of femoral head
① Research into reconstructive surgery② Research into microsurgical research and clinical application③ Basic and clinical research of keloids in wound④ Development of new operating methods in the hand surgery⑤ Research into the application of adipose tissue derived stem cells in the reconstructive surgery⑥ Application of amniotic membrane and placenta-derived stem cells for tissue repair① Reasearch about the achievements and limitations of traditional psychiatry② Research about the current state of the art and challenges of the latest robotic and avatar technologies③ Research about the current state of artificial intelligence technology and challenges in its application to psychiatric medicine④ Research on the use of tele-operated medicine to improve psychiatric services⑤ Research about the consciousness and sensory trait for psychiatric disorders
Medical and pharmaceutical research and development of new drugs and health foods based on the demands of international and①
regional (glocal) society② Research on mental wellbeing, mental health, and related technologies and assessments③ Research on strengthening international and regional partnerships and exchanges and education
Establishment of a novel therapeutic stratedies for anhidrosis and hyperhidrosis based on a physiological and functional analysis of①
human sweat gland② Establishment of immune cell transfusion therapy for both skin cancer and cutaneous lymphomas③ Investigation to formulate the novel therapeutic strategies for allergic diseases based on scientific grounds④ Survey for epidemiology of allergy, and evaluation of buren in patients with allergic skin diseases
Survey for actual condition and epidemiological investigation of skin infection (e.g. fungal disease, acid-fast bacteria, and bacterial⑤
infection, etc.)
Diagnosis of rare intractable diseases and development of new treatments for those diseases (e.g. pseudoxanthoma elasticum, Fabry⑥
disease, and neurofibromatosis, etc.)
Investigaion for biomarkers and microbiomes which are of benefit to involved in treatment options for skin diseases (e.g. psoriasis,⑦
atopic dermatitis, etc.)⑧ Establishment of novel therapeutic strategies focusing on the both microenvironment and matrix of skin tumors⑨ Pathological and physiological analysis of sensory abnormalities (e.g. pruritus and pain) and tactile dysfunction① Basic and clinical research on the mechanisms and treatment of arteriosclerosis and pulmonary hypertension② Development of biomarkers of cardiovascular disease and its clinical application③ Research on the application of chronotherapy to cardiovascular disease④ Association of myocardial tissue changes with genetic abnormlities of cardiomyopathy and lethal arrhythmia⑤ Epidemiology of acute myocardial infarction in Nagasaki⑥ Research on the relationship between cancer and cardiovascular disease⑦ Research on the application of adipose tissue derived stem cells in cardiovascular regenerative medicine⑧ Research on implementation of a regional clinical pathway for cardiovascular disease① Molecular biology, mutations and pathology of hepatitis virus② Interferon signals within hepatic cells③ Life and death of hepatic cells④ Early diagnosis and carcinogenic inhibition of hepatic cell cancer⑤ Development of new treatment methods for digestive organ cancer⑥ Digestive organ disorders and metabolic syndrome⑦ Pathological analysis and development of new treatment methods for autoimmune hepatitis⑧ Pathological analysis and development of new diagnostic methods for D198:D205hypersensitivity pneumonia

36

Area of Research

Professor, etc.

Respiratory
Medicine

MUKAE Hiroshi(Professor)

Laboratory
Medicine

YANAGIHARA Katsunori(Professor)

Pediatrics

MORIUCHI Hiroyuki(Professor)
DATEKI Sumito(Associate Professor)

Radiological
Science

TOYA Ryo(Professor)

Clinical Oncology

ASHIZAWA Kazuto(Professor)

ClinicalPhysiology

KURATA Shinji(Associate Professor)

Orthodontics and
Dentofacial
Orthopedics

YOSHIDA Noriaki(Professor)

Pediatric
Dentistry

TANOUE Naomi(Associate Professor)

Periodontology
andEndodontology

YOSHIMURA Atsutoshi(Professor)

Applied
Prosthodontics

SAWASE Takashi(Professor)
KUROSHIMA Shinichiro(Associate Professor)

Details of main research work
① Clarification of effect of anaerobic bacteria co-infection on other infectious diseases② Pathogenesis of fungi and mechanisms of antifungal resistance③ Development of novel diagnosis and therapeutic strategies for respiratry fungal infections④ Elucidating the pathogenssis and development of novel immunological treatments for invasive bacterial pneumonia⑤ Development of new molecularly-targeted treatment for pulmonary fibrosis⑥ New evaluation of environmental risks of obstructive pulmonary diseases (COPD and bronchial asthma)⑦ Clarification of molecular targeted drug-resistant mechanisms in driver-mutation positive lung cancer⑧ Development of novel therapeutic agents for pleural malignant mesothelioma⑨ Analysis of adverse events in the immune checkpoint inhibitors⑩ Development of new cell therapy for pulmonary fibrosis① Research into new methods of diagnosing infectious diseases② Clarification of drug-resistant mechanisms and research into drug resistant bacteria control③ Clarification of severe infection mechanisms and development of new treatment methods④ Research about the role of microbiota on human health⑤ Clarification of ATL pathology and development of new treatment methods⑥ Establishment of custom-made diagnostics for neoplasm and infection⑦ Development of new antimicrobials① Epidemiological and clinical research into mother-to-child infections② Investigation on involvement of coronaviruses in the onset of Kawasaki disease③ Research on reactogenecity to COVID-19 vaccine④ Investigation on prevalence of antimicrobial resistant bacteria among infants and toddlers in the community⑤ Research into hereditary diseases and genetic diagnosis⑥ Clinical and Genetic research into short statures⑦ Clinical and Genetic research into pediatric endocrinologic disorders⑧ Research into genetic etiologies of undiagnosed congenital diseases① Diagnostic imaging of inflammatory and degenerative diseases② Imaging and staging of malignant tumors③ Application of molecular imaging into radiotherapy planning④ Physics analysis and clinical application of high-precision radiation therapy① Research into management of pulmonary nodules using diagnostic imaging② Research into molecular imaging for use in determining effectiveness of cancer treatments③ Cutting edge clinical cancer research involving clinical trials on cancer drug treatments in multi-organ cancer cases④ Development of novel therapeutic strategies in rare cancers① Research into management upper airway patency during sleep and anesthesia② Investigation on influence of anxiety on pain perception③ Research into functional role of opioid receptor④ Investigation on ischemia reperfusion injury of liver circulation⑤ Investigation on swallowing disorder① Biomechanical analysis of orthodontic tooth movement② Effect of soft diet feeding on masticatory function development and craniofacial growth③ Etiology and pathogenesis of stomatognathic function disorders④ Mechanisms of root resorption induced by orthodontic tooth movement⑤ Development of orthodontic diagnosis and treatment support system using AI⑥ Development of treatment system for achieving efficient tooth movement⑦ Mechanisms of osteoclast differentiation and its control① Molecular biological research of pathogenic factors of dental caries and periodontal disease② Molecular biological research of teeth and craniofacial growth and development③ Development of new congnitive behavioral therapy④ Materials-based approach to dental and oral diseases① Physical properties and clinical results of endodontic tools and materials② Wound healing mechanism in pulpitis and apical periodontitis③ Pulp regenerative medicine and biomaterials④ Analysis of alveolar bone resorption mechanism⑤ Role of immune system in periodontal tissue breakdown⑥ Epidemiological study of periodontal diseases⑦ Analysis of virulence factors of periodontopathic bacteria⑧ Associations between periodontal disease and systemic disease① Biocompatibility and biodynamics of dental implants② Understanding of pathophysiology of and treatment strategy for MRONJ③ Manufacture, clinical application and evaluation of polymers/composite materials/ceramics④ Surface modification of dental materials① Research into the development and clinical application of dental materials such as soft denture liners and denture adhesives

Prosthetic
Dentistry

MURATA Hiroshi(Professor)

Oral and
Maxillofacial
Surgery

YAMADA Tomohiro(Professor)

Radiology andBiomedical
Informatics

SUMI Misa(Professor)② Research into mastication function and jaw movement③ Clinical research of prosthetic dentistry④ Maintenance of dentures⑤ Development of swallowing function and choking risk assessment system using artificial intelligence⑥ Development of the oral simulator to enable highly predictive dental treatment① Basic and clinical research on maxillofacial deformities and congenital anomalies② Basic and clinical research on oral tumors③ Basic and clinical research on oral and maxillofacial reconstruction④ Research on treatment support systems using digital technology① Diagnostic imaging of head and neck tumors② Diagnosis and treatment of Sjögren's syndrome③ Deep learning approach for imaging diagnosis④ DNA damage and repair mechanisms

37

Area of Research

Professor, etc.

Medical Researchand Development
for Oral Disease

SUMITA Yoshinori(Professor)

Pharmacotherape
utics

TSUKAMOTO Kazuhiro(Professor)
HIRAYAMA Tatsuro(Associate Professor)

Pharmaceutical
Informatics

KAWAKAMI Shigeru(Professor)
MUKAI Hidefumi(Associate Professor)

Pharmaceutics

NISHIDA Koyo
(Professor)

Pharmacy
Practice

NAKASHIMA Mikiro(Professor)

Molecular
Pathochemistry

OHYAMA Kaname(Professor)
KODAMA Yukinobu(Associate Professor)

Nursing Sciences

ETO Hiromi(Professor)
HONDA Sumihisa(Professor)
SAWAI Terumitsu(Professor)
ISHIMATSU Yuji
(Professor)
KURODA Hiromi(Professor)
MATSUURA Emi(Professor)
TANAKA Junichi(Associate Proffesor)

Physical Therapy
Sciences

KOZU Ryo(Professor)
OKITA Minoru(Professor)
ORIGUCHI Tomoki(Professor)
SAKAMOTO Junya(Associate professor)

Occupational
Therapy Sciences

IWANAGA Ryoichiro(Professor)
IMAMURA Akira(Professor)

Health Sciences

OHNISHI Mayumi(Professor)
HIGASHI Toshio(Professor)
KOSEKI Hironobu(Professor)
SATOH Katsuya(Professor)
HIRANO Yuko
(Professor)

Preventive
Medicine

KOBAYASHI Masakazu(Associate Professor)

MedicalInnovation

TANAKA Yoshimasa(Professor)

Details of main research work
① Translational research of novel cell and gene therapies for jaw and alveolar bone defects② Translational research of novel cell therapies for xerostomia (atrophic salivary glands)③ Research into the function of tissue specific macrophages on morbid aged salivary glands④ Research into the function of megakaryocytes on bone metabolism and regeneration① Research into DNA-based diagnostic methods for personalized medicine
Research into association studies on susceptibility genes for diseases, progression, drug effectiveness, adverse effects, and②prognosis using genetic polymorphic markers③ Research into antifungal drug-resistance mechanisms of pathogenic fungi① Research into targeted DDS using external stimuli from medical equipment② Research into medical applications of nanobiotechnology③ Development of novel nucleic acid medicine encapsulated lipid nanoparticles (LNPs)④ Development of designer bacterial drugs for the treatment of refractory cancer⑤ Development of new PET probes and novel methods for pharmacokinetic analysis① Research on drug delivery system aiming to develop new administration forms
Development of control method for distribution of genetic medicine in the body and its pharmaceutical formulation with the②
purpose of optimizing treatment③ Research on kinetic analysis of drug disposition in the body and dosage regimen under diseased state① Basic and clinical pharmaceutical research of drugs and their proper use② Practical scientific research based on drug preparation and medical communication in the clinical setting③ Development of sequence decoding method for protein antigenization④ Development of highly targeted drug delivery system① Clinical application and advanced research of comprehensive analysis of immune complexes② In-house production of blood drug measurement by LC-MS/MS and research on drug treatment design based on large-scale data
③ Research on optimization of drug treatment and proper use of drugs by artificial intelligence④ Elucidation of the molecular basis of hibernation⑤ Development of drugs and genetic delivery systems① Research on midwifery and women's health② Research on sleep of mother and child③ Research on health promotion for the community citizens④ Research on into ostomy rehabilitation⑤ Research on prevention for perioperative complication⑥ Research on chronic respiratory nursing⑦ Research on infection control nursing⑧ Research on cardiovascular nursing⑨ Research on people with sleep disturbance⑩ Research on chronic disease nursing⑪ Research on collagen disease nursing⑫ Research on health literacy⑬ Research on acute care nursing⑭ Research on children's health and nutrition① Clarification of the mechanism for locomotive disorders (joint contracture, muscle atrophy, pain, etc)
② Research and development in rehabilitation for musculoskeletal diseases③ Research and development in rehabilitation for cancer④ Clinical research on rehabilitation for acute and chronic cardiorespiratory disorders⑤ Epidemiological study for early detection and secondary prevention of chronic obstructive pulmonary disease⑥ Research on rehabilitation for rheumatic diseases⑦ Fundamental and clnical research on pain in rehabilitation① Research for assessment of children with developmental disabilities② Research for dysfunction of sensory and motor in the individuals with autism spectrum disorder③ Research on psychiatric rehabilitation④ Research on investigation and support of addiction⑤ Research on the biological basis of autism spectrum disorder and schizophrenia① Research on health promotion for the community citizens② Research in improving the health of people living under disadvantaged conditions③ Research on rehabilitation for the disabled④ Kinematic analysis and research of arthroplasty for gonarthrosis⑤ Microstructure analysis and strength measurement of disuse bone atrophy⑥ Joint kinetic analysis of wrist and ankle⑦ Research and development in rehabilitation for neurological disease and muscle disease⑧ Research and development in diagnose for dementia disease and rehabilitation for the prevention of dementia disease⑨ Research on transfer of Japan’s care technology to Asian countries⑩ Research on the Sense of Coherence and its implication to health⑪ Research on life adaptation and stress coping of foreign health workers in Japan① Research into the effects of lifestyle on physical and mental health in young adults② Research into the effects of lifestyle factors on physical and mental health in workers① Development of novel combination cancer therapy harnessing PD-1 immune checkpoint inhibitors② Development of novel cancer immunotherapy harnessing gd T cells③ Development of novel cancer immunotherapy harnessing nanobodies④ Development of novel cancer immunotherapy harnessing natural products

Community
Network for
Health Welfare
Endocrinology
and Metabolism

38

Area of Research

Professor, etc.

Clinical
Neuroscience

TSUJINO Akira(Professor)
TATEISHI Yohei(Senior Assistant Professor)

Nephrology

NISHINO Tomoya(Professor)

Emergency
Medicine

TASAKI Osamu(Professor)

Rehabilitation
Medicine

TAKAHATA Hideaki(Associate Professor)

Details of main research work
① Development of new diagnostic and therapeutic techniques for the neurological diseases② Research on molecular, pathological and physiological mechanisms underlying the neurological diseases③ Epidemiological and statistical analysis of omics and clinical data in the neurological diseases④ Biomarker development for precision medicine in the neurological diseases⑤ Translational research and clinical research of regenerative medicine in the neurological diseases① Research into mechanisms of kidney diseases and development of new treatment methods② Basic and clinical research into renal replacement therapy including hemodialysis, peritoneal dialysis and kidney transplantation③ Epidemiological and clinical research into chronic kidney disease④ Research into mechanisms and new treatment for complication of chronic kidney disease① Pathophysiological clarification of sepsis, and research into the development of treatment② Pathophysiological clarification of ischemia-reperfusion injury, and research into the development of treatment③ Pathophysiological clarification of severe trauma, and research into the development of treatment④ Pathophysiological clarification of heatstroke, and research into the development of treatment⑤ Research into nutrition management of critically ill patients① Research on prevention and treatment of dysphagia and pneumonia in stroke patients② Study of dysphagia in critical care patients③ Studies on myonuclei and satellite cells for muscle regeneration in critically ill patients

Neurological
Science
Neuroimmunology

HIGUCHI Osamu(Professor)

Comprehensive
Community Care

MINE Takashi(Professor)
ICHIKAWA Tatsuki(Professor)

Comprehensive
Oncology

GOTO Koichi(Professor)
KONDO Tadashi(Professor)
IGAKI Hiroshi(Professor)
ISHIAI Masamichi(Professor)
WATANABE Keisuke(Associate Professor)

Precision
Oncology andTranslational
Research

FUJITA Shin
(Professor)① Development of targeted drug for neurological diseases② Development of drug discovery platform targeting protein kinases③ Development of measurement technology for neurological disease biomarkers① Research into comprehensive community care system② Research into the policy for community health③ Research into network system for comprehensive community care
④ Research into primary health care in local community⑤ Research into dementia and mild cognitive impairment in community⑥ Research into assessment for sarcopenia⑦ Viral hepatitis and metabolic syndrome① Research into fundamental causes and prevention of cancer② Research into diagnosis and treatment for cancer③ Research into cancer pathophysiology and survivorship④ Research into precision medicine for cancer patients⑤ Development of cellular immunotherapies for cancers⑥ Development of medical devices and programs for cancer treatment① Clinical research into precision medicine for cancer patients② Translational research of cancer

39

②Areas of Research in Department of Infection Research
Area of Research

Immunology

Cellular and Molecular
Biology

Infectious Diseases

Medical Virology

Microbiology and Oral
Infection

Molecular Virology

Bacteriology

Medical Protozoology

Biochemical
Parasitology

MedicalHelminthology

Professor, etc.

Details of main research work

① Research on innate immunity② Research on antigen presenting cells③ Research on T cell responses④ Research and development of type 1 innate immune activator
AOSHI Taiki⑤ Research and development of PDX disease model(Professor)⑥ Research and development of new antimalarial drugs
INOUE Shin-Ichi⑦ Induction of IL-27 producing regulatory T cells (Tr27 cells) and their roles in the regulation of chronic infection(Associate Professor)⑧ IL-27-related regulation of immunological memory during malaria infection⑨ Molecular mechanism of memory CD4+ T cell-differentiation and their persistence during malaria infection⑩ Mechanism underlying immune response of γδ T cells and their roles in malaria infection⑪ Mechanism of complicated Plasmodium vivax malaria in India① Analysis of prion pathogen behavior and infection/proliferation mechanisms② Analysis of host immune response in regard to prion infection, and development of immunomodulation therapy③ Research into development of viral infection and prion infection diagnosis methods④ Research into development of new drug treatments for pathogens
Analysis of antifungal resistance mechanisms and virulence, and development of novel diagnostic tools and treatments①
for the infections caused by pathogenic fungi (Aspergillus, Candida, and Cryptococcus)
IZUMIKAWA Koichi ② Investigation of the molecular basis of host-pathogen interaction for bacteria causing the respiratory infection（Professor）
Investigation of epidemiology and pathogenesis of the emerging, re-emerging infectious diseases as well as diseases③
caused by drug-resistant pathogens④ Intervention for the preventing the spread of hospital-acquired infection① Technical innovation in molecular viral diagnostics
UNO Naoki② Molecular assay development for pathogen detection and quantification(Associate Professor)
NISHIDA Noriyuki(Professor)① Analysis of transport and secretion system of pathogenic factors in periodontal pathogen
NAITO Mariko(Professor)② Molecular biological analysis of pathogenic factors of periodontal and relative bacteria
SHOJI Mikio③ Search and development of antibacterial drugs targeting periodontal pathogen(Associate Professor)① An Intracellular dynamics of highly pathogenic viruses using live cell imaging system② Molecular replication machinary of highly pathogenic viruses (flaviviruses, alphaviruses, filoviruses and bunyaviruses)
Molecular mechanisms of pathogenicity in highly pathogenic viruses (flaviviruses, alphaviruses, filoviruses and③bunyaviruses) infection
TAKAMATSU Yuki
Seroepidemiological and molecular epidemiological studies of arthropod-borne viruses (e.g. Japanese encephalitis virus,(Associate Professor) ④
Dengue virus, Zika virus, Chikungunya virus, etc)
Development of diagnostic, therapeutic and preventive measurements against arthropod-borne viruses (e.g. Japanese⑤
encephalitis virus, Dengue virus, Zika virus, Chikungunya virus, etc)
⑥ Analysis of SARS-CoV2 pathogenecity and development of diagnostic and therapeutic methods① Research on pathogenesis of enteropathogenic bacteria
KODAMA Toshio② Immune response and host defense mechanism to enteropathogenic bacteria(Professor)③ Molecular epidemiological study on enteropathogenic bacteria in endemic areas① Molecular mechanisms of erythrocyte invasion and modification by malaria parasite② Molecular epidemiology of malaria vaccine candidate antigens and drug-resistance genes
KANEKO Osamu③ Evolution of malaria parasites(Professor)④ Understanding the biology of the dormant liver stage of malaria parasites⑤ Development of vaccines, drugs and diagnostic tools for malaria① Entamoeba lipid metabolism; biochemistry, molecular and cell biology, and physiology
MI-ICHI Fumika② Study for the molecular mechanism underlying Entamoeba encystation(Professor)
Construction of metabolic pathway of Entamoeba histolytica and identification of the targets for the development of③
anti-amoebiasis drugs
The parasitic diseases to be targeted: Neglected Tropical Diseases (NTDs) such as Schistosomiasis, Leishmaniasis,
Trypanosomiasis, Amebiasis, etc.
Spatio-temporal epidemiology, behavioral change communications in Africa in addition to research and development for
HAMANO Shinjiro ①
new monitoring methods and drugs for parasitic diseases(Professor)② Research and development of new vaccines and diagnostic methods against parasitic diseases③ Research on immune response and host defense mechanisms against parasites④ Research on survival strategies and pathogenicity of parasites

Immunogenetics
Clinical Investigation
Ecoepidemiology andEpidemiological
Informatics in Tropical
Medicine

KANEKO Satoshi(Professor)① Research on the establishment of a large-scale surveillance system for neglected tropical diseases② Research on the linkage between environmental DNA and epidemiological data on tropical diseases③ Research on the application of biometrics to regional medical information systems④ Epidemiological study on growth retardation (stunting) in children in developing countries⑤ Study on electronic resident registration and maternal and child registration in developing countries⑥ Epidemiological study on fungal mycosis

40

Area of ResearchInternational Healthand Medical
Anthropology

Vector Ecology andEnvironment

Clinical Tropical
Medicine

Tropical Pediatric
Infectious Diseases

Professor, etc.

Details of main research work

① Research into international health policy (G8 and the Conference on African Development)② Reassembly of infectious disease on a time axis (study of ancient infectious diseases)③ Molecular evolutionary research into maternal-child HTLV-1 infection④ Infectious diseases and climate change (the environment)/changes to ecosystems⑤ Research into the history of medicine relating to the history of tropical medicine in JapanYAMAMOTO Taro
⑥ Research into factors in the spread of AIDS in the Greater Mekong Economic Corridor and China(Professor)⑦ High altitude medicine from evolutionary perspective⑧ Field research in microbiome and modern epidemic⑨ Study on Mathematical Infection Model of STIs
⑩ Application of Game Theory to Drug Resistance Drugs⑪ Research on oral health, stress and birth outcomes among pregnant women in developing countries① Biology of malaria vector mosquitoes in tropical regions② Biology of viral disease vector mosquitoes in tropical regions
MINAKAWA Noboru ③ Malaria and dengue vector contorl tools(Professor)④ Impacts of environmental changes and climate variability on insect vectors⑤ Modeling COVID-19 and malaria⑥ Ecology and control of non-mosquito vectors such as tsetse flies, sandflies, ticks, etc.
① Clinical epidemiology of acute respitatory tract infection among adult
KUBO Yoshinao② HIV and AIDS in developing countries(Associate Professor) ③ Clarification of acute respiratory infection in developing countries, and countermeasures④ Pathological clarification of other tropical infectious diseases in developing countries, and countermeasures① Clinical epidemiology and microbiology of paediatric infectious diseases in tropical regions② Pediatric Acute Respiratory Infection: clinical epidemiology, etiology, pathogeneis, prevention and treatment
YOSHIDA Lay-Myint③ Clinical epidemiological and modelling studies on impact of vaccination and other intervention(Professor)④ Statistical analysis of disease surveillance data
⑤ Environmental factors and infectious diseases

Clinical ProductDevelopment
Tropical Bacteriology① Epidemiological study on arbovirus infectious diseaseｓ in the tropical area and pathogenic analysis② Investigation of emerging viral diseases in the tropical area and development of quick diagnostic method
Tropical Microbiology③ Epidemiological and ecological study on viral infectious diseases in Southeast Asia
④ Development of an innovative method to detect viral diseases① Molecular mechanisms of replication of hemorrhagic fever viruses
Development of novel anti-viral strategies against highly pathogenic viruses (especially influenza, SFTS, Ebola,②
Emerging Viral
YASUDA Jiro
Marburg and Lassa viruses)③ Development of diagnostic methods for emerging viral diseases
Diseases(Professor)④ Analyses of the pathogenicity of SARS-CoV-2 and development of the treatments for COVID-19⑤ Epidemiological and ecological studies on viral diseases in Africa① Molecular mechanism of infrction and pathogenesis of Filovirus
Cellular and Molecular
NANBO Asuka② Characterization of extracellular vesicles released from tumor virus-infected cells
Virology(Professor)③ Molecular mechanism of development of Epstein-Barr virus-associated epithelium tumors④ Development of therapeutics and diagnosis for Filovirus and tumor viruses-associated diseases① Persistence and transmission of arthropod-borne viruses in hosts
YOSHII Kentaro② Pathogenic mechanisms of arthropod-borne viruses
Viral Ecology(Professor)③ Development of diagnostic methods and epidemiological research of arthropod-borne viruses④ Development of vaccines and therapeutics for arthropod-borne viruses① Study of vairal immune response in cultured cells
Immune Dynamics in KAWASAKI Takumi ② Analysis of Immune dynamics in laboratory animals during viral infections
Viral Infections(Associate Professor) ③ Elucidation of the mechanisms of viral replication and virulence④ Applied research for prevention and diagnosis for viral infections
IMAIZUMI Yoshitaka ① Research on the clinical pathogenesis and prognosis of refractory tumors
Integrative Regulation(Professor)② Clinical research on the medical treatment of malignant tumors in the elderly① Development and proposal for public policy about viral hepatitis
KOMORI Atsumasa ② Development and proposal for public policy about intractable liver diseases
Healthcare Research(Professor)
Characterization and proposal for patient-centered outcomes-based medicine in viral hepatitis and in intractable liver③
diseases① Clinical research of hepatitis C and B, and research into the development of treatment methods② Research into analysis of medical and genetic information using data mining
YATSUHASHI
Viral Hepatitis
Hiroshi③ Research into the genetic mutation, pathology and treatment of hepatitis virus(Professor)④ Studies on the pathophysiology and treatment of liver fibrosis and cirrosis⑤ Clinical research on the development of liver cancer and its suppression
HASEBE Futoshi(Professor)

41

Area of Research

Advanced Research

Professor, etc.

Details of main research work

Development of molecular target therapy for refractory autoimmune liver diseases (primary biliary cholangitis,①
autoimmune hepatitis)
NAKAMURA Minoru② Development of order-made treatment for chronic viral hepatitis based on individual analysis of immune-response(Professor)
Development of regenerative medicine for diseases in the liver/bile duct based on molecular mechanisms for cellular③
damage/regeneration

Molecular Immunology
Function andMorphology

Clinical Pathology

Basic Mycobacteriosis

Clinical
Mycobacteriosis① Diagnosis and surgical treatment for liver cancers hepatic cancer, intrahepatic bile duct cancer, etc.
② Clinical and experimental research into regenerative capacity and mechanisms in liver diseases③ Development of the novel assessment method for hepatic functional reserve hepatic cell transplant methods④ Clinical and experimental research into the relationship between hepatocellular carcinoma and lifestyle diseases① Clinical and pathological research into viral hepatitis/hepatic neoplasm
ITO Masahiro② Clinical and pathological research into refractory autoimmune hepatic disease(Professor)③ Molecular pathological research into neoplastic disorders④ Clarification of occurrence mechanisms for radiation-induced neoplasm
MITARAI Satoshi ① Research on the development and evaluation of bacteriological diagnostic methods for tuberculosis② Research into drug-resistant mechanisms in mycobacteria and their diagnosis/treatment(Professor)
KEICHO Naoto③ Epidemiological research on Mycobacterial diseases including molocular analysis(Professor)④ Analytical research on the relationship between mycobacterial function and its microstructure
OHKADO Akihiro ⑤ Functional analyses of mycobacteria with OMICS information(Associate Professor) ⑥ Research on mycobacterial infection, development and recurrence of the disease at genetic, molecular and cellular levels① Clinical research into treatment of susceptible pulmonary tuberculosis② Research into DOTS (Directly Observed Treatment Short-course)
SHIRAISHI Yuji
③ Clinical research into multi-resistant tuberculosis(Professor)
OHTA Ken④ Clinical research (including clinical trials) into the effectiveness of new antituberculosis drug treatments(Professor)⑤ Research into non-tuberculous mycobacterial disease
MORIMOTO Kozo ⑥ Research into pulmonary rehabilitation for patients with mycobacterial disease(Professor)⑦ Pathophysiological analyses of systemic inflammation and sarcopenia in pulmonary mycobacteriosis⑧ Pulmonary rehabilitation and nutritional strategies for pulmonary mycobacteriosis
KUROKI Tamotsu(Professor)

42

③Areas of Research in Department of Life Sciences and Radiation Research
Area of Research

Radiation Medical
Sciences

Professor, etc.

Details of main research work

MITSUTAKE① Molecular mechanisms of thyroid cancer development
Norisato② Elucidation of mechanisms of ionizing radiation-induced carcinogenesis(Professor)
SUZUKI Keiji(Associate Professor)

Radiation Molecular
Epidemiology
Radiation Biology andProtection
Radiation andEnvironment Health
Effects① Research on radiation dosimetry② Research on radiation protection③ Research on radiation risk communication① Epidemiological research in local population
HAYASHIDA Naomi ② Research on health effects due to radiation(Professor)③ Research on thyroid
YOKOYAMA Sumi
(Professor)

Genome Repair

Stem Cell Biology

Hematology

Radioisotope Medicine

LI Tao-Sheng(Professor)

MIYAZAKI Yasushi(Professor)

KUDO Takashi(Professor)① Translational studies on stem cells (cardiovascular diseases, wound healing, cancer, aging…)② Understand how low dose radiation exposure affects the health by viewing the stem cells③ Characterize cancer stem cells and uncover the mechanism on therapeutic resistance④ Investigate the role of autophagy on genomic instability⑤ Basic and translational studies on biomechanical stresses① Development of new diagnostic methods and treatments for hematopoietic diseases② Molecular analysis for the pathogenesis of hematopoietic neoplasms③ Epidemiology and pathological research for radiation-induced hematopoietic diseases④ Molecular analysis for hematopoietic stem cells⑤ Development of treatments for hematological disorders using hematopoietic cell transplantation and immunotherapy① Research into the clinical/pre-clinical use of radioisotopes② Research into measurement of human low dose internal radiation③ Research into risk/benefit assessment of the medical radiation and occupational radiation related to medical radiation usage

International
Hibakusha Medical
Sciences

43④Areas of Research in Division of Advanced Preventive Medical Sciences
Area of Research
Neurobiology and
Behavior

Professor, etc.
NAKAHATA
Yasukazu(Associate Professor)

Public Health

AOYAGI Kiyoshi(Professor)

Medical Informatics

MATSUMOTO
Takehiro(Associate Professor)

Community Medicine

NAGATA Yasuhiro(Professor)

Immunology andRheumatology

KAWAKAMI Atsushi(Professor)

General Medicine

MAEDA Takahiro(Professor)

Global Health,
TAKAMURA Noboru
Medicine and Welfare(Professor)

Human Genetics

YOSHIURA Koichiro(Professor)

Details of main research work
① Successful aging by revealing molecular mechanisms of how the circadian clock regulates aging process② Discovery of bioactive natural products that activate the circadian clock③ In vivo study to control the aging process by the circadian clock① Community health based on health promotion science② Prevention of bone/joint disease③ Industrial health④ Prevention of lifestyle-related disease⑤ Physiological polymorphism based on physiological anthropological research① Development and evaluation of Hospital Information System② Development and evaluation of Health Information Exchange③ Hospital management using Medical DX④ Development and evaluation of Hospital Information System for medical Safety① Research in community medicine② Research into the epidemiology of life-style related disease③ Research into community medical information and partnerships④ Research into community-based medical education⑤ Research into comprehensive community care system① Research into causes and pathology of autoimmune disease/autoinflammatory disease and development of new treatment② Integrated analysis of arthritis: Etiology,Pathology and Therapy③ Genetic and environmental analysis of autoimmune disease and autoinflammatory disease④ Onset mechanisms for autoimmune disease brought on by viral infection⑤ Multimodal investigation of Preclinical-RA and Pre-RA by genomic, immunological and environmental approach⑥ Multimodal investigation of connective tissue disease associated interstitial lung disease⑦ Research into causes and pathology of refractory autoimmune neural disease⑧ Research into causes and pathology of lifestyle-related disease and development of new treatment⑨ Radiation exposure and thyroid cancer⑩ Reserch of osteoporosis: pathological aspect and advanced treatments① Epidemiological study for prevention of lifestyle-related diseases② Research into pathophysiology and prevention/treatment regarding functional somatic syndrome③ Research into medical information sharing in community④ Research into pathophysiology and prevention regarding sarcopenia/frailty⑤ Research into rare diseases in primary care
① Environmental monitoring of Fukushima② Evaluation of exposure doses in Fukushima③ Risk perception of residents in Fukushima④ Epidemiological study of victims around Chernobyl Nuclear Power Plant① Identification of the genes responsible for onset of disease② Research into the relationship between human genetic polymorphism and disease③ Research into the control of genetic expression through epigenetics mechanisms④ The creation of disease model mice and pathophysiolological analytical research thereof⑤ Development of methods to quantify radiation damage

Molecular Medicine

Tumor and Diagnostic
Pathology

NAKASHIMA
Masahiro(Professor)① Research into molecular pathological specificity of neoplasms in atomic bomb Hibakusha② Research into late-onset radiation-induced disorders③ Creation of Hibakusha neoplasm tissue bank
④ Pathology of thyroid neoplasm⑤ Research into pathological diagnostics and new molecular pathological diagnostics

44Doctoral Course [3 years]①Areas of Research in Department of Pharmaceutical Sciences
Area of Research

Professor, etc.

Details of main research work

Cell Regulation

TAKEDA Kohsuke(Professor)

Pharmacology
and Therapeutic
Innovation

KANEKO Masayuki(Professor)
TSUKAHARA
Tamotsu(Associate Professor)

Pharmaceutical
Chemistry

TANAKA Masakazu(Professor)
UEDA Atsushi(Associate Professor)

Pharmaceutical
Organic
Chemistry

ISHIHARA Jun(Professor)

Synthetic
Chemistry for
Pharmaceuticals

KURIYAMA Masami(Associate Professor)

Genome-based
Drug Discovery

IWATA Nobuhisa(Professor)
SHIROTANI Keiro(Associate professor)

Natural ProductChemistry

SAITO Yoshinori(Associate professor)① Development of highly selective organic reactions for synthesis of pharmaceuticals② Exploitation of reactions for efficient synthesis of unnatural amino acids③ Exploitation of methods for selective molecular transformations of polyols④ Development of environmentally friendly oxidation reactions for production of bulk chemicals① Analysis of molecular mechanisms underlying the pathogenesis of Alzheimer's disease② Development of disease-modifying therapy and biomarker of Alzheimer's disease③ Analysis of pathophysiological roles of convulsive neurological disease-causing gene PRRT2 in the synapse④ Analysis of tissue-specific gene expression mechanism in eukaryotes① Structural investigation and appliaction of functional natural products② Dynamic chemistry of polyphenols in plants and biomimetic molecular conversion③ Chemical diversity of plant secondary metabolites

Medicinal Plant
Biochemistry

YAMADA Koji
(Associate Professor)① Research into the bioactive constituents of medicinal plants② Drug development research into the physiologically active component substances in marine invertebrates③ Drug development research into physiologically active component substances derived from marine microorganisms

Structure
Analysis for
Chemicals

MAKI Toshihide(Associate Professor)① Design and development of photofunctional molecules② Research into structure-activity relationship of bioactive compounds based on organic chemistry③ Exploitation of practical synthetic methodologies and their application for medicinal chemistry

Chemistry of
Biofunctional
Molecules

YAMAYOSHI Asako(Professor)
YAMAMOTO
Tsuyoshi(Associate professor)① Development of nucleic acid drugs for functional regulation of non-coding RNAs
② Novel drug delivery system using circulating extracellular vehicles③ Development of novel photodynamic genome editing system targeting provirsu genome

Hygienic
Chemistry

TORIBA Akira(Professor)
ABIKO Yumi
(Associate professor)

Analytical
Chemistry for
Pharmaceuticals

KISHIKAWA Naoya(Associate professor)① Environmental dynamics analysis for atmospheric organic pollutants② Studies on human exposure and health effects of environmental pollutants③ Studies on cellular responses against environmental pollutants and effect of combined exposure④ Analysis of trace elements in biological systems and synthesis of biologically active nanosphere containing metals① Development of luminescence reagent and its application to biomedical analyses② Development of ultra sensitive analytical method for trace biologically active substances and pharmaceuticals③ Development of new delivatization methods for mass spectrometry④ Development of rapid separation method for biologically active substances① Roles of mitochondrial sensing and stress response② Mitochondrial functions in the regulation of inflammation③ Mechanisms of inflammatory death of macrophage lineage cells④ Molecular mechanisms of cell motility① Physiological roles and drug discovery of ubiquitin ligases② Analysis of gene function and drug discovery using genome editing③ Drug discovery based on the translation, transport, and metabolism of protein④ Lipid mediators in inflammation disorders⑤ Lysophosphatidic acid signaling in the nervous system⑥ Drug discovery and development; From Lipid molecules to medicine① Design and synthesis of non-proteinogenic amino acids and their use in pharmaceutical chemistry② Development of helical peptides as an asymmetric organocatalyst③ Design of cell-penetrating foldamers and their application to drug delivery system① Synthesis of biologically active natural products② Development of highly effective formation of carbon framework③ Development of reaction diversity catalysts

45