Eugene Consulting Inc.
408-25 Montgomery Ave
Toronto, ON
M4R 0A1

October/November 2021 Report

Ring Therapeutics- Ring Therapeutics is a biotechnology company revolutionizing the gene therapy andnucleic acid medicine space by pioneering the development of a new class of viral vector- They developed the Analogy platform, which harnesses the commensal virome ofanelloviruses (a community of viruses found naturally within humans), which overmillion of years of evolution have derived highly favourable properties such as potentiallyenhanced tropism and immune tolerance- Partnered with Flagship Pioneering, the company aims to develop and further expand its
portfolio by leveraging its platform to successfully dose therapeutic cargos in a potentiallysafer and more targeted manner to unreachable organs and tissues elusive to current
therapiesfffNautilus and Abcam Announce Strategic Partnership to Accelerate Exploration of theProteome - November 2, 2021
- Nautilus Biotechnology Inc. announced a strategic development and supply partnershipwith Abcam, a global innovator in life sciences research tools- The partnership leverages Abcam’s industry-leading recombinant monoclonal antibody
development technologies and expertise to enhance Nautilus’ reagent research anddevelopment- The companies have also established a long-term supply relationship- The partnership will initially focus on the collaborative development of af inity binding
reagents for use on the Nautilus proteomic analysis system- In the near future, they plan to expand in the near future to the large-scale manufactureand supply of reagents for commercialization- Under the terms of the agreement, Abcam will provide Nautilus with antibodies that are
expected to add to and enhance its own library of af inity binding reagents- At the end of 2021, Nautilus also signed their second and third research collaborations both will utilize the Nautilus platform across a number of projects to investigate proteinsand proteoforms of interest- A global pharmaceutical company- An investigator at the University of Texas MD Anderson Cancer Center- The company also shared a manuscript that introduces the theoretical foundation for a
fundamentally different approach to proteomics, called Protein Identi ication by Shortepitope Mapping (PrISM)

Eugene Consulting Inc.
408-25 Montgomery Ave
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Nautilus Biotechnology third quarter 2021 inancial results:- Operating expenses: $14.6 million- 262% increase from 4 million for the 3 months ended September 30, 2020
- Net loss: $14.5 million compared to 4 million for the corresponding prior year period- Cash, cash equivalents, and investments were $374 million as of September 30, 2021
Amazon has made a deal with Hilton for their healthcare platform Amazon Care
- Amazon has announced a newly inked deal with Hilton- The deal entails Hilton employees being able to access Amazon’s healthcare platform foron-demand medical services- Hilton’s interest in Amazon Care is a testament to evolving industry interests andAmazon’s commitment to disrupting the healthcare system,

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Amazon itness tracker - Halo View
- Halo View is the newest addition to the Halo collection- It retails for $79.99, plus an additional $3.99 monthly fee for the Halo membershipafter the irst year
- It comes in three colours: sage green, lavender dream and active black- It’s available in sizes small/medium or medium/large- There are also 15 additional sports bands available for purchase starting at $14.99
and 8 fabric bands for $29.99 each
- It is water-resistant and swim-proof up to 50m- 7 day batter life that fully charges in 90 minutes- Halo View features:- Counts steps- Accounts for key health metrics like heart rate and blood oxygen levels- It sends texts and reminder noti ications- Includes a tone analysis option, which allows for users to analyze how their tone ofvoice may be perceived by others- Halo smartphone app- Through the Halo smartphone app, users have access to tracking sleep temperature,
time awake and asleep, calories burned, heart rate, steps, activity sessions, andlimited workouts, recipes, and individualized programming- An additional active membership ($3.99 a month), allows users to access a slew ofadditional perks including tools to manage sleep, enhance exercise, measure bodycomposition, and more
- The app will also soon be upgraded to include Halo Fitness and Halo Nutrition- The itness portion will offer hundreds of exclusive workouts - including
access to workouts from Orangetheory, SWEAT, Aaptiv, and more
- Users will also have the opportunity to take a “movement assessment”
through the app to create a personalized exercise program and will also beEugene Consulting Inc.
408-25 Montgomery Ave
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able to use their smartphone camera and Halo app to measure body fat
percentage- The Halo’s Body feature is nearly twice as accurate as leading at-home smart
scales and a personalized 3D model helps you track changes- Halo also uses the smartphone camera to accurately measure your mobility,
stability, and posture and then provides a personalized plan to help you
improve over time
- The nutrition portion of the app will include personalized meal planning tools andrecipes from WW, Lifesum, and Whole Foods Market- Members can easily add ingredients for recipes and additional groceries
directly to their Alexa shopping list
- Halo nutrition is planned to launch in January 2022

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Amazon’s Alexa is inding a voice in healthcare settings- Amazon is launching a new service for hospitals that will embed its voice technology
deeper into clinical settings at scale- As part of Alexa Smart Properties, the service will simplify how hospitals and seniorliving facilities deploy and manage Alexa-enabled devices across their properties- Ways in which Alexa can be used in hospitals:- Alexa devices in hospital rooms can help patients keep in touch with their families,
connect with care team members, easily access news and information, and playmusic
- Patients can also ask Alexa for things they need - ex. “Alexa, tell my nurse I needpillow”- The use of AI to interpret patient intent enables the message to be sent to theappropriate are team member using existing hospital communication systems- Senior living communities such as Atria and Eskaton and hospitals including BostonChildren’s, Cedars-Sinai, BayCare and Houston Methodist have signed on to add Alexa tosome of their facilities- While hospitals are keen to integrate voice technology into the patient experience, achallenge has been to manage the device at scale- In 2019, Clearwater, a Florida-based BayCare Health System piloted the technology at two
hospitals- They deployed Amazon Alexa devices in 2,500 rooms across its 14 hospitals- The aim was to provide patients with smart rooms that allow them to connect with
their care team and control devices like the television, hand-free- In 2019, Cedars-Sinai also piloted Amazon Alexa devices in more than 100 patient rooms
to enable patients to interact hands-free with nurses and control their entertainment- Early during the COVID-19 pandemic, hospitals and senior living communities reached
out to Amazon to enable Alexa voice solutions, as supplies of PPE were limited

Eugene Consulting Inc.
408-25 Montgomery Ave
Toronto, ON
M4R 0A1- Based on feedback from the early pilots, Amazon added features to support senior living
facilities and hospitals, such as the ability for video capabilities and Drop In - features thatenable providers to communicate with patients without the need to enter their rooms- Hospitals can also provide information customized to their facility, such as noti ications
about schedule changes or cafeteria menus- By working with solution providers like K4Connect, Lifeline Senior Living, Aiva andVocera, senior living and healthcare properties can use Alexa Smart Properties tocustomize large numbers of Alexa-enabled devices and make it easy for solution
providers to manage and service the devices quickly, remotely and at scale- The company has stated that no personal information is shared with Alexa to use thedevice and that voice recordings are not saved- They have also implemented administrative, technical and physical safeguards forprotected health information review as part of HIPAA-eligible skill interactionsff- In July of 2021, Amazon’ cloud division rolled out AWS for Health - a set of services andpartner solutions for healthcare, genomics and biopharma- AWS for Health is intended to help organizations increase the pace of innovation, unlock
the potential of health data, and develop more personalized approaches to therapeutic
development and care
- There services within AWS for Health can help healthcare customers create holistic
electronic health records to help clinicians make data-driven care plans and power
population genomic initiatives to expand precision medicine accessibility- Microsoft, Google and AWS are pushing deeper into healthcare in a battle to provide cloudcomputing and data storage technology to hospitals- As part of AWS for Health, Amazon announced the general availability of Amazon
HealthLake - a tool to make it easier for healthcare organizations to search and analyze
data- Amazon HealthcareLake is a HIPAA-eligible service for healthcare and life sciences
organizations that aggregates an organization’s complete data across various silos
and disparate formats into a centralized AWS data lake and automaticallynormalizes this information using machine learning- The service identi ies each piece of clinical information, tags indexes events in atimeline view with standardized labels so it can be easily searched- It also structures all of the data into the Fast Healthcare Interoperability Resources(FHIR) industry-standard format for a complete view of the health of individual
patients and entire populations- HealthLake’s natural processing also allows for the extraction of information suchas medication, diagnosis, and previous conditions from doctors’ clinical notes to
examine barriers to healthcare access- Alongside AWS for Health, Amazon HealthLake has the potential to help medical
providers, health insurers, and pharmaceutical companies provide patients andpopulations with data-driven, personalized, and predictive careEugene Consulting Inc.
408-25 Montgomery Ave
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M4R 0A1- Other organizations using Amazon HealthLake include Cortica, InterSystems and RedoxfAmazon Alexa used in Healthcare in Canada- A pioneer in geriatric care in Toronto, Onatrio, Baycrest is an academic health sciences
centre that provides continuum of care for over 1,200 older adults- In response to COVID-10, Baycrest restricted visitors to campus and limited the external
and internal mobility of residents to combat the virus- This isolation proved challenging for patients’ mental health- To support patients, Baycrest launched their Telemedicine Rapid Implementation
team- This team stationed Amazon Echo dots in public spaces and on travelingtelemedicine carts for residents to listen to music, do charades, or practice a skill- Baycrest also plans to implement smart suites which are comprised of smart lighting,blinds, and thermostats connect to Amazon Show
- The simplicity of using voice-based technology has made this technology easily accessible
to Baycrest residents- During the pandemic when much human resources were being used to screen for
symptoms of COVID-19, McGill University Health Center launched a pilot program theylaunched a screening for COVID-19 at the cardiology clinic- This worked effectively for 215 patients, demonstrating that voice-based
technologies can be used to ef iciently screen patients and their families for
symptoms of COVID-19- Alexa asked patients screening questions in both French and English- Patients and families reported that they felt comfortable using the system andthat it was easy it use - especially for the older patient population- The team is now developing a COVID=19 vaccine chat bot to help answer commonly
asked questions around the COVID-10 vaccines- By automating part of the intake process, they demonstrated that such technologies
could reduce the burden on their healthcare teams- University Health Network (UHN) is the largest teaching hospital in Canada and the teamhas launched a digital health intervention called Medly to help patients and families selfmanage care for heart failure- Patients use a smartphone app to measure blood pressure, weight, and their
symptoms daily- The app’s algorithm advises the patient on medication use and self-care bestpractices, ultimately notifying the clinic if required- Through this initiate, UGN successfully reduced the amount of hospitalizations by
more than 50% and worked to improve health outcomes- Despite the program’s success, accessibility to smartphone decides can be achallenge for certain populations and the team believes that voice command tools
such as the Alexa platform can be a good complement or alternative to using
smartphone apps

Eugene Consulting Inc.
408-25 Montgomery Ave
Toronto, ON
M4R 0A1- As a result, the team launched an Alexa version of the Medly application, creating avisual aspect for the Echo Show to drive engagement- Through a clinical pilot with 20 patients, UHN discovered that for certain patients,
voice-based technology was much more user friendly and drove higher
participation than the app-based system- Alexa is also more cost effective than a smartphone- The UHN team is working towards implementing this solution into clinical use after
acquiring the necessary quality and security checks - supported by AWS

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Microsoft’s $19.7 billion acquisition of speech recognition and healthcare AI company
Nuance- In April 2021, Microsoft bought AI speech tech irm Nuance for $19.7 billion- Microsoft will pay $56 per share for Nuance - a 23% premium over the company’s closing
price- Nuance is best known for its Dragon software, which uses deep learning to transcribe
speech and improves its accuracy over time by adapting to a user’s voice- Dragon is an industry leader in terms of transcription accuracy- Nuance’s licensed tech is used for Apple’s digital assistant Siri
- This is Microsoft’s second-largest purchased behind LinkedIn- In 2019, Microsoft and Nuance announced a strategic partnership to use Nuance’s
software to digitize health records for Microsoft clients- Nuance’s health tech, including its Dragon Medical One platform, which is tuned to
identify medical terminology, is reportedly used by more than half a million physicians
worldwide and in 77% of US hospitals- Nuance’s solutions with help to augment the Microsoft Cloud for Healthcare and help
Microsoft empower healthcare providers through the power of ambient clinicalintelligence and other Microsoft cloud services- Over the years, Nuances’ technology has evolved to include the ability to learn medical
terminology, languages and accents- In recent years, Nuance applied AI to its software for new use cases, including ambient
clinical documentation- In this case, a smart speaker in an exam room picks up on key words during apatient visit and can translate the relevant speech into actions or activities within
the EHR- Ex. A physician using voice command to order medications or add a diagnosis to thechart- Microsoft’s acquisition of Nuance is certain to accelerate the use of AI and natural
language processing within clinical work lows