Eisai Environmental Report 2023

Ongoing Efforts to Ensure Coexistence with the Global Environment
The Eisai Group conducts business operations while emphasizing protection of the global environment based on the Eisai Network Companies (ENW)
Environmental Protection Policy.

Enhancing environmental activities to provide solutions to social issues

Eisai Network Companies (ENW) Environmental Protection Policy

The protection of the global environment, which is the foundation of our business activities, is not only an
important management issue for Eisai, but also has a significant impact on the lives of patients and people
in the daily living domain. It is also closely connected to contributing to social sustainability from a long-term
perspective as stated in our Articles of Incorporation. Under the ENW Environmental Protection Policy andEnvironmental Management Vision, Eisai is committed to providing solutions to social issues by enhancing
its environmental activities.
In July 2023, UN Secretary-General António Guterres sounded the alarm over the accelerating climate
crisis, describing it as “global boiling.” The Sixth Assessment Report (AR6) of the Intergovernmental Panelon Climate Change (IPCC) also considers climate change a pressing issue for all humanity to addressand calls for urgent and effective action, warning that what we do in the next decade will determine what
happens in the future.
Eisai has set science-based target based on a 2°C scenario (SBT＊ 2.0°C targets) in May 2019, and is
working to reduce its greenhouse gas (GHG) emissions. In fiscal 2022, we succeeded in reducing emissions
by 60% compared to the baseline FY2016 level. Since fiscal 2019, we have been accelerating the shift
to renewable energy-derived electricity (renewable electricity) in our business activities, and the ratio ofrenewable electricity in our electricity consumption in fiscal 2022 is 95.4%.
We also plan to obtain approval by the SBT initiative (SBTi) for our science-based targets based on a
1.5°C scenario (SBT 1.5°C targets) in fiscal 2023. Going forward, our environmental activities will focus
more on the sustainable use of water and other resources and the conservation of biodiversity. At the sametime, we will steadily advance our efforts to achieve carbon neutrality by fiscal 2040. We are also looking
at initiatives to achieve net zero emissions in collaboration with our supply chains to realize a decarbonizedsociety.

Basic Policy
Eisai Co., Ltd. and its Group companies (“ENW”) contribute to the health and welfare of people around the world and therealization of a sustainable society by developing business activities that emphasize harmony with the global environment.

Action Guideline
1. Establish an environmental management system and strive to reduce the environmental impact of all aspects of our businessactivities.
2. Promote environmental protection activities in compliance with environmental laws, regulations, and agreements.
3. Contribute to the mitigation of climate change by reducing greenhouse gas emissions and promoting energy conservation.
4. Contribute to the formation of a recycling-oriented society by promoting the sustainable use of resources, including water,
along with waste reduction and recycling.
5. Prevent environmental pollution by promoting proper management of chemical substances and reducing their use.
6. Contribute to the realization of a society in harmony with nature by developing business activities that take into consideration
the conservation of biodiversity.
7. Systematically provide education and enlightenment on environmental protection to raise awareness of environmental issues
among all employees.
8. Strive to improve our credibility with society through proactive disclosure of environmental information and communication
with local communities.
9. Promote environmental protection in our supply chain in cooperation with our business partners.

＊ SBT: Abbreviation for Science Based Targets, representing targets for science-based greenhouse gas emission reduction1

Manufacturing and Drug Discovery Research Sites Worldwide●European Knowledge Centre (United Kingdom)
Benxi Plant (China)●
Suzhou Plant (China)●●
Vizag Site (India)

G2D2 (United States)＊ ●H3
Biomedicine
Inc.
(UnitedStates)
Plant(Gifu)●Kawashima●●Kashima Plant (Ibaraki)
Baltimore Plant (United States)●●Exton Site (United States)●Tsukuba Research Laboratories (Ibaraki)●KAN Research Institute, Inc. (Hyogo)●EA Pharma Co., Ltd., Fukushima Plant (Fukushima)●EA Pharma Co., Ltd., Drug Discovery Research Institute (Kanagawa)●Bogor Plant (Indonesia)＊ Closed in the second half of fiscal 2022

Editorial Policy

Period Covered

This report describes the Eisai Group’s approach toward environmental protection and provides details of environmental
activities undertaken during fiscal 2022. The report has been developed in reference to the Environmental Reporting
Guidelines (2018 Version) issued by Japan’s Ministry of the Environment and includes Eisai’s efforts both in Japan andoverseas.

The data has been aggregated based on the results achieved from April 1, 2022 to March 31, 2023.

Scope of Reporting
The scope of data aggregation in this report primarily covers Eisai Co., Ltd. and its Group companies in Japan (hereafter,
Eisai Group in Japan) as well as its production sites and research laboratories outside Japan. The scope of individual data is
specified as needed.

2

Glossary and CO2 Emissions Coefficient
Glossary

Energy Consumption and CO2 Emissions Coefficients Used in Emissions Calculations

Term

Description

ISO 14001

An international standard for environmental management issued by the International Organization forStandardization

Zero emissions

The Eisai Group uses this term as a target for emissions control. It indicates a ratio of waste sent tolandfill to total waste of less than 0.5%

PRTR

Pollutant Release and Transfer Register: A system for understanding, collecting and publicly
disclosing information on the extent to which chemical substances with environmental risk are either
released into the environment or contained as waste matter and transferred from operational sites

Act on Controlling
Emissions of
Fluorocarbons

The abbreviated title of the Act on Rational Use and Proper Management of Fluorocarbons. The
purpose of the act is to prevent the leakage of fluorocarbons that cause depletion of the ozone layer
or global warming at each stage from production to disposal

SOx

Sulfur oxides

NOx

Nitrogen oxides

BOD

Biochemical Oxygen Demand: A measure used to evaluate the quality of river water and factory
wastewater

Scope 1

Energy-derived direct greenhouse gas (GHG) emissions. GHG emissions released directly into theatmosphere through the use of fuels

Scope 2

Energy-derived indirect GHG emissions. GHG emissions associated with the use of purchased
energy (electricity and heat)

Scope 3

Other indirect GHG emissions. GHG emissions that result from business activities in the supply
chain and are not contained within either Scope 1 or Scope 2

VOCs

Volatile Organic Compounds: Organic compounds that are volatile at ordinary temperatures andcause air pollution through the generation of photochemical oxidants

Energy type

Calorific value per unit
FY2022CO2 emissions coefficient
FY2018〜

FY2013〜2017＊1

Electric power

9.97 (GJ/MWh)

LPG

50.1 (GJ/tons)

3.01 (tons/tons)

3.01 (tons/tons)

LNG

54.7 (GJ/tons)

2.78 (tons/tons)

2.78 (tons/tons)

Natural gas

39.3 (GJ/1,000 Nm )32.00 (tons/1,000 Nm )3

2.04 (tons/1,000 Nm )3

Processed natural gas

40.0 (GJ/1,000 Nm )3

2.04 (tons/1,000 Nm )3

2.09 (tons/1,000 Nm )Kerosene

36.5 (GJ/kl)

2.50 (tons/kl)

2.50 (tons/kl)

Light oil

38.0 (GJ/kl)

2.62 (tons/kl)

2.62 (tons/kl)

Fuel oil A

38.9 (GJ/kl)

2.76 (tons/kl)

2.76 (tons/kl)

Gasoline

33.3 (GJ/kl)

2.28 (tons/kl)

2.28 (tons/kl)

Industrial steam

1.02 (GJ/GJ)

Hot water and coldwater

1.36 (GJ/GJ)

3＊20.057 (tons/GJ)

0.057 (tons/GJ)＊1 Emissions coefficients reported by suppliers are used in the calculation for the Eisai Group in Japan. To calculate emissions outside Japan,
coefficients provided by local representatives are mainly used.
＊2 E
 missions coefficients provided by suppliers are used for calculation.

3

1

Environmental Protection Initiatives and Results

Fiscal 2022 Environmental Protection Initiatives and Results of the Eisai Group in Japan
Category

Initiatives

Enhancement and smooth operation ofmanagement systems

Enhancement ofenvironmental Planning and implementation of environmental
education
management

Implementation of environmental
communication

50% reduction of CO2 emissions (Scopes 1+2)
compared to fiscal 2016 levels (global)

Renewable energy-derived electricity
introduction ratio of 80% or greater (global)

Energyconservationand combatingclimate change

Waste reduction

Results

Evaluation Pages• Proper application of the PDCA cycle• ISO 14001 regular and recertification inspection (Kawashima
Plant, Kashima Plant, Drug Discovery Research Institute andFukushima Plant of EA Pharma Co., Ltd.)○• Internal training sessions: 154, external training sessions: 8○• Published Eisai Environmental Report 2022
• Local community meetings: Held in paper-based report format(Kawashima Plant)• Administrative committee meetings: Not held (Kashima Plant)• Information exchange meetings: Not held (Fukushima Plant of
EA Pharma Co., Ltd.)△• CO2 emissions (Scope 1+2): 53,612 tons
(60.2% decrease from fiscal 2016)○• Introduction ratio of renewable energy-derived electricity:
95.4%-Purchased 48,387 MWh of non-fossil certificates (derived
from biomass power generation)○

P8

Managementof chemical
substances○

P11

Introduction of internal carbon pricing (global)• Introduced in August 2022○

P9

Proper management of fluorocarbons• Conducted statutory inspections in compliance with the Act on
the Rational Use and Proper Management of Fluorocarbons,and systematically switched to alternative chlorofluorocarbons.
• The calculated total fluorocarbons leaked was less than 1,000
t-CO2e, so we are not required to report it.

○• Amount of waste generated: 4,255 tons
(decrease of 156 tons from fiscal 2021)• Amount of waste sent to landfill: 13.0 tons
(increase of 1.6 tons from fiscal 2021)△• Reduction of waste generated• Reduction of waste sent to landfill

○

P9

P15

P13

Resource
conservation(Eisai Co., Ltd.)

Biodiversity(global)• Recycled amount (including valuables): 2,656 tons
(decrease of 444 tons from fiscal 2021)• Recycling rate (including valuables): 45.5%(decrease of 6.9% from fiscal 2021)• Waste plastic recycling rate: 90.5%(increase of 20.9% from fiscal 2021)△

P13

Implementation of onsite inspections based on
the Waste Management and Public Cleansing
Law• Conducted on-site inspections at 45 sites nationwide inaccordance with the Act on Waste Management and Public
Cleansing and confirmed that there was no illegal dumping.

○

P13

Response to PRTR system and proper
management of designated substances• Proper management based on an understanding of amountsof substances subject to the PRTR system that were handled,emitted and transferred○

P14

Promotion of awareness-raising activities andeducation to encourage green purchasing• Implemented awareness-raising and education activities
whenever appropriate• The green purchasing ratio: 34.4% (1.7% increase from fiscal
2021)

○

P15

Reduction of copy paper usage• Utilized electronic materials and web meetings• Used 11,954,749 sheets of copy paper (decrease of 8.1%
from fiscal 2021)○

P13

Encouraging biodiversity protection initiatives,
including the protection of rare organisms andthe regional environment• Naito Museum of Pharmaceutical Science and Industry:
Maintained 38 endangered species in healthy condition andcompleted propagation of 5 additional species• Kashima Plant: Selected tree species and planted threecerasus speciosa trees• Vizag Site: Engaged in an afforestation program and planted
approximately 2,000 trees in the state of Andhra Pradesh,
India, where the operation site is located

○

P16

○

P8, 17

Air pollution and• Regular measurements showed that the amounts of pollutant
Compliance with Air Pollution Control Act,water pollution
Water Pollution Control Act and pollution control emissions into the atmosphere and water systems were below
prevention
standard values
agreements
measures

Conservationof the local
environment

Evaluation Pages
P13

P9, 10P10

Results△

Increasing the volume of recycling- 50% or greater recycling rate (including
Waste reduction
valuables)- 80% or greater waste plastic recycling rate

P8

Promotion of the replacement of company
vehicles with hybrid vehicles (Eisai Co., Ltd.)• Submitted the application to the SBTi in March 2023

Initiatives• Eisai Co., Ltd.: 0.31%
Attainment of zero emissions• Eisai Group companies in Japan: 0.19%(Ratio of waste sent to landfill to total waste < 0.5%)• Eisai Group in Japan: 0.85%

P8• Adoption rate for company vehicles (12-month average. The
same applies hereinafter): 91.1%(15.9% increase from fiscal 2021)• Adoption rate for company-owned vehicles: 94.4%(20.4% increase from fiscal 2021)• Adoption rate for employee-owned vehicles: 78.3%(0.2% increase from fiscal 2021)

Preparation for acquiring SBT 1.5°C targets
approval (global)

Category

Compliance with environment-related laws
(noise, vibrations, offensive odors, soil
contamination)• Regularly measured levels of noise, vibrations and offensive
odors to confirm compliance○

P8

Involvement with local community• Held regular cleanup activities of areas around each operationsite and affiliated company as well as within industrial parks

○

—

○

—

Zero complaints made by neighboring residents No complaints were reported
Legend used in “Evaluation” section: ○ Achieved; △ Partially achieved; × Not achieved

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2

Resource Input and Environmental Impact

Fiscal 2022 Resource Input and Environmental Impact Data of the Eisai Group in Japan

Environmental Impact

OUTPUT
Atmospheric Emissions (from operational sites)
Eisai Co., Ltd.

INPUT
Water

EnergyEisai Co., Ltd.

Electric power (MWh)Group companies
in Japan

Eisai Co., Ltd.

Total

Water consumption (1,000m3)

3,312Group companies
in Japan

152

3,464

18,504105,199

LPG (tons)

8

11

19

Clean water (1,000m )

122

109

LNG (tons)

0

1,494

1,494

Industrial water (1,000m3)

1

44

45

7,540

372

7,913

Groundwater (1,000m3)

3,179

0

3,179

Kerosene (kl)

0

32

32

Desalinated water (1,000m3)

10

0

10

Light oil (kl)

2

0

3

Recycled water (1,000m3)

80

2

82

Gasoline (kl)

767

335

1,102

Processed natural gas (1,000 Nm3)

Fuel oil A (kl)Industrial steam (GJ)

16

0

17

56,658056,658

Hot water (GJ)

92

0

92

Cold water (GJ)

196

0

196

Copy paper consumption(10,000 sheets)

Total amount handled(including unreported amount)(tons)

Eisai Co., Ltd.

Group companies
in Japan

Total

290

39

328

720

2,463

7

46

53

28,259SOx (tons)

0.1

NOx (tons)

11.2

0.4

11.7

Soot and dust (tons)

0.5

0.0

0.6

Indirect CO2 Emissions (Scope 3＊)

18

0.5

19

Eisai Co., Ltd.

Group companies
in Japan

Total

Purchased goods andservices (tons)

376,830

81,008457,838

Capital goods (tons)

44,597

6,532

51,128

Fuel- and energy-related
activities not includedin Scope 1 or 2 (tons)

7,771

1,261

9,032

Transportation and delivery(upstream) (tons)

625

422

1,046

PRTR substances(release into the atmosphere) (tons)

Waste

CO2 emissions frombusiness-use vehicles otherthan commercial vehicles (tons)

Eisai Co., Ltd.

Group companies
in Japan

Total

Amount generated (tons)

3,496

759

4,255

Amount recycled (tons)

733

345

1,078

7

6

13

2,212

117

2,329

Waste generated
in operations (tons)

5,619

625

6,244

Business travel (tons)

396

249

644

Employee commuting (tons)

284

854

1,138

Transportation and delivery(downstream) (tons)

1,271

328

1,598

634

695

1,329

Wastewater discharge

Eisai Co., Ltd.

Group companies
in JapanTotal(1,000m3)

1,195

537

1,732

BOD (tons)

6.8

0.1

6.8

Nitrogen (tons)

2.5

0.1

2.6

Phosphorous (tons)

0.1

0.1

0.1

PRTR substances

172

38

210

0.0

0.0

0.0

Note: Due to rounding off, the sum of “Eisai Co., Ltd.” and “Group companies in Japan” may not correspond to “Total” for some items.

Total

1,743

0.0

Amount sent to landfill (tons)

PRTR Substances

CO2 emissions fromcommercial vehicles (tons)

Group companies
in Japan

7,821

230

Other

Eisai Co., Ltd.

0.1

Total

86,696

3

Exhaust Gas from Vehicles

Total

20,438CO2 (Scope 1, 2) (tons)

Resource Input

Group companies
in Japan(off-site transfer as waste) (tons)

PRTR substances(release into water bodies) (tons)

End of life treatment ofsold products (tons)

Containers and Packaging Recycling
Recycling of containers
and packaging materials

Eisai Co., Ltd.

Group companies
in Japan

Total

2,682

96

2,779

(obligatory recycling amount) (tons)＊ Calculations based on the Basic Guidelines on Accounting for Greenhouse Gas Emissions Throughout the Supply Chain, Version 2.4 andthe database to account for Greenhouse Gas Emissions of Organizations Throughout the Supply Chain, Version 3.2 (released by the Ministryof the Environment and the Ministry of Economy, Trade and Industry). However, commuting-derived emissions and waste treatment-derived
emissions were calculated based on Version 2.6.

5

3

Environmental Accounting

The Eisai Group in Japan calculated the total environmental costs to confirm the environmental costs incurred and effects (results) of environmental protection activities by referring to the “Environmental Accounting Guidelines(2005)” published by the Ministry of the Environment. We will make improvements to ascertain the economic effects associated with environmental protection measures and enhance the usefulness of the form as amanagement index.
Environmental Protection Costs in Fiscal 2022 (In “Major implementation items,” ○ indicates investment and △ indicates expense.)
Main category

A. C
 osts to achieve objectives

Subcategory○ Investment

Major implementation items

1. Environmental management systems△ ISO 14001 regular and recertification inspections

05

2. Energy conservation and measures to address climatechange○ Renewal of air conditioners○ Replacing refrigerators, freezers, water heaters, etc. with new ones
○ Conversion to LED lighting△ Maintenance of humidifiers/air conditioning facilities△ Purchase of overseas power certificate△ Purchase of non-fossil certificates

14

125

3. Resource conservation activities△R eplacing of component parts of wastewater treatment system△ Green purchasing

0

1,535

4. Air pollution prevention measures△ Measurement of soot and dust
△ Measurement of working environment2

5. Management of chemical substances△ Creation of SDS (Safety Data Sheet)△ Expenses for maintaining the reagent management system

6. Waste reduction activities○ Installation of new piping for waste oil tanks△ Outsource of waste disposal

7. Product design

B. Costs to comply with environmental
regulations

C. Environmental administration costs(million yen)
△ Expense

Major results / outcomes• Promotion of environmental protection activities

Pages
P7

• Replacement with more energy-efficient equipment
P9-12• Purchase of 57,530 MWh• Purchase of 60,189 MWh• Recycled water: 820,000 m3• Promotion of purchasing environmentally friendly products

P15

6• Prevention of air pollution

P8,17

0

3

• Communication of the information handling hazardous chemical substances• Proper management of chemical substances

—

1

202

• Amount of waste generated decreased by 156 tons
• Recycled amount decreased by 516 tons
• Amount sent to landfill increased by 1.6 tons

P13
—

0

0

1. Waste disposal△ Management of waste treatment facilities△ Expenses for fluorocarbons and asbestos removal

068• Compliance with related laws and regulations

P13,15

2. Pollution prevention measures○ Replacing Dailite’s synthetic wastewater tanks○ Replacing high-pressure steam sterilizing devices△ Wastewater treatment facilities management expenses△ Maintenance and cleaning of various septic tanks△ Wastewater, noise, vibration and odor measurements

35

107

• Prevention of contaminant discharge

P8,17

3. Soil contamination△ Costs for geographical history survey00• Prevention of soil and groundwater contamination

P8

4. Recycling of containers and packaging△ Subcontracting of container and packaging recycling

030• Compliance with the Containers and Packaging Recycling Act

P5

1. Environment-related costs excluding A and B△ Greenery maintenance and management costs△ Publication of the Environmental Report 2022
△ Verification of CO2 emissions

064• Promotion of business activities that coexist with nature• Improved communication

P16

51

2,145

＊

Total
＊ Includes depreciation costs

Economic Effect of Environmental Protection MeasuresItem(million yen)

Details

Sales of by-products

Proceeds from selling recyclable items

Reduction in synthetic solvent expenses through recycling

Reduction in synthetic solvent expenses through distillation of waste solvent in the production process

Total

Amount26
11
37

Scope of calculations: Eisai Group in Japan
Period of data collection: April 1, 2022 through March 31, 2023
Notes: 1) Figures are rounded to the nearest hundred thousand yen.
2) Since fiscal 2004, personnel costs have included only the subcontractors’ commissions.

64

Environmental Management

Eisai Environmental Management Vision

The Eisai Group not only delivers pharmaceuticalproducts to patients and people in the daily living
domain, but also provides solutions tailored to theirdiverse needs. In doing so, our goal is to achieve
two social goods: relieving anxiety over health andreducing health disparities. We consider the global
environment to be the foundation of our businessactivities for the realization of social good. Therefore,
we recognize that environmental protection isextremely important to our Group, which aims torelieve anxiety over health.
In 2021, the Eisai Group updated the Eisai
Network (ENW) Environmental Protection Policy, andPromotion Structure
under this policy, we are standardizing Group-wide
efforts and committed to protecting the environment.
In April 2022, the Eisai Group formulated theEisai Environmental Management Vision, withthe mid-term goal of systematically addressing
and promoting issues such as climate change,sustainable water use, recycling of resources,
biodiversity conservation, and proper managementof chemical substances with the aim of achievingcarbon neutrality by 2040. Through this, we aim
to efficiently realize the social goods that the Eisai
Group aims to achieve.

Eisai Environmental Management Vision
Two social goods we would like to achieve• Relieve anxiety over health• Reduce health disparities

Global environmental protection goals we would like to achieve• Stopping climate change caused by global warming• Preventing marine pollution by marine plastics, etc.
• Maintaining the ecosystem• Securing water resources, and others

Under the supervision of the Board of Directors,
the Eisai Group has established the Company-wide
Environment and Safety Committee chaired by the
Corporate Officer responsible for Environmental
and Safety Affairs. The Committee deliberates andmakes decisions on important agenda items related
to environmental safety. In addition to promoting
global activities such as reduction of GHG emissions
and efficient use of resources, the Committee
contributes to the strengthening of activities to
identify environmental risks in Japan and overseas
and establish countermeasures to address theserisks. Important environmental issues related tothe entire Eisai Group that are discussed by theCommittee are reported to the Executive Committee,
Structure to Promote Environmental Management
Board of Directors

Corporate Officer Responsible
for Environmental & Safety Affairs

Achieving social good and global environmental protection
is our responsibility as an hhc (human health care) company<Eisai Environmental Management Vision>(1) We will work sincerely to realize the Company’s two goals for social good, and at the same time to protect the global environment as
set forth in the basic policy and action guidelines of the ENW (Eisai Network Companies) Environmental Policy.
(2) We will become a leader in environmental protection activities, clearly demonstrating our significance to society.
(3) As leaders in environmental protection activities, each of us will pursue the most efficient ways of achieving social good by changing
the way we work and the structure of our business.
(4) We will contribute to society’s sustainability through our environmental protection efforts, which will also lead to increased nonfinancial value.

the highest decision-making body of the businessexecution departments, for deliberation, resolution,and implementation. Resolutions of the Companywide Environment and Safety Committee are sharedwith the Eisai Group companies in Japan andoverseas at meetings of the Domestic Eisai Network
Environment and Safety Conference and Global Eisai
Carbon Neutrality Information Sharing Meeting, and
the Group work together in addressing these issues.
Each operational site has established its own
environmental management system and promotes
environmental activities. The main production
sites in Japan as well as the Suzhou Plant in
China and Vizag Site in India have all obtained ISO
14001 certification and are conducting activities
in accordance with the ISO standards, while also
striving to raise environmental awareness throughactivities such as facilitating environmental educationand training to address environmental risks. In
addition to complying with environmental laws,
ordinances and agreements, we periodically conduct
internal environmental audits by a department
specializing in internal auditing to identify andresolve issues.
General Affairs andEnvironmental & Safety
Affairs Department

Environment and Safety
Conference of Group
Companies in Japan

Company-WideEnvironment
and Safety Committee

Group Companies in Japan

Eisai Co., Ltd.
Head Office, Plants, Sales Offices

Global Eisai Carbon Neutrality
Information Sharing Meeting

Overseas Group Companies

Operational Sites Certified under ISO 14001●Kawashima Plant and Kashima Plant, Eisai Co., Ltd.
●Fukushima Plant, EA Pharma Co., Ltd.
●Suzhou Plant, Eisai China Inc.
●Vizag Site, Eisai Pharmaceuticals India Pvt. Ltd.

7

Environmental Education
In order to promote environmental protection
activities in harmony with the global environment,
it is necessary for all employees take ownershipof environmental issues, correctly understand how
the issues are connected to their everyday workand raise their environmental awareness to solve
problems. Each operational site formulates andimplements its own educational plan according
to the characteristics of and problems within
their operations. For example, our head office
departments and sales offices are promoting energy
saving and efficient use of resources throughpractices such as the optimal use of office lighting

Environmental Communication
and air-conditioners as well as paperless work in thecreation of documents. In addition to programs forall employees, we also have programs for various
job levels and are working to enhance them. We also
provide online courses for employees so that they
can learn in the current telecommuting environment.
Depending on the external environment, we are also
flexibly promoting the development and training of
employees in charge of environmental education andthose who have acquired official qualifications. We
also encourage them to participate in specialized
courses held either internally or externally that aredesigned to improve their own skills.

Internal Audits
We undergo environmental audits by a specialized
audit organization. Internal audits include domestic
and overseas Eisai Group companies, and isconducted objectively from an independent
standpoint. Due to the impact of COVID-19, audits infiscal 2022 included site visits and remote audits,
including those of overseas Eisai Group companies.
No urgent or serious problems were detected. ISO
14001-certified plants and companies undergo anannual external audit to confirm the effectiveness of

their environmental management systems, andtraining is provided to enhance the skills of
personnel conducting internal audit. The results ofannual internal audits are reflected in the continuous
improvement of environmental management system,
leading to qualitative improvement of ourenvironmental protection activities. In fiscal 2022, noserious problems were identified by the external
audit organization.

Compliance with Laws and Regulations
The Eisai Group in Japan strives to comply withenvironment-related laws, regulations, ordinances,
and agreements with local governments, whilesetting voluntary standards that are stricter thanenvironmental laws and regulations. Our plants andlaboratories periodically measure their environmentalloads, such as air and water pollution and confirm
that they are equal to or below the standard values.

From the perspective of protecting the surrounding
environment, we also regularly measure noise,
vibration, and odors in the vicinity of our plants andlaboratories to confirm that the levels are equal to or
below the standard values. In fiscal 2022, we did notreceive administrative penalties or fines, nor were
we the subject of any environmental lawsuit.

Our connections with shareholders and investors
We disclose important management information,
including non-financial information related toenvironmental protection, in an active, fair, equitable,
timely and easy-to-understand manner. At the sametime, we often engage in face-to-face and online
dialogue to better communicate with shareholders
and investors.
Connections with local communities
Mutual understanding and cooperation with local
communities are important as we carry out ourbusiness activities. The Kawashima Plant invites
representatives of residents in surrounding
communities and local government officials tothe plant to explain the Plant’s operations andenvironmental protection activities and to hear theiropinions and requests. In addition, the Fukushima
Plant of EA Pharma Co., Ltd. holds informationexchange meetings focusing on environmental
protection and regional contribution activities.
In fiscal 2022, the Kawashima Plant held themeetings in paper-based reporting format due to the
COVID-19 pandemic, while EA Pharma’s Fukushima
Plant cancelled the meetings at the request of thelocal government.

The fiscal 2022 Kawashima Plant area local community meeting(written document cover)Environmental Risk Management
The Eisai Group in Japan has compiled procedures
for responding to environmental accidents in its
Disaster and Accident Response Manual and theIndustrial Accident Reporting and Compilation
Standards. We strive to gather accurate information
and address problems quickly and appropriately,
minimize damage and ensure the thoroughprevention of recurrences. Our plants andlaboratories periodically conduct emergency drills
to prepare for emergencies that could have a major
impact on the environment, such as the leakage oremission of hazardous chemicals from wastewater,
exhaust gases, waste liquids or other sources.

Environmental Incident Report
There were no environment-related accidents in fiscal 2022.

8

5

Efforts toward the SDGs

Initiatives for the Formation of a Carbon-Free Society

Activities to achieve carbon neutrality by 2040

In May 2021, the Eisai Group issued the Statementof Commitment for Carbon Neutrality. We haveformulated medium- and long-term targets anda roadmap, and are actively working to mitigate
climate change and achieve a sustainable society.

Internal Carbon Pricing (ICP)
ICP, which aims to reduce CO2 and other greenhouse gas (GHG) emissions, is a measure in which companies voluntarily set a price on the
GHGs they emit from their business activities. For example, ICP is used to make decisions regarding capital investments. The Eisai Groupset its ICP at 11,000 yen (80 euros as of this setting time) per ton of CO2, referring to the European carbon tax and emissions trading price,and proposed capital investment with this as the environmental value.

1. Switch all of the electricity used in our business activities to renewable energy by 2030 (Reduce Scope 2 CO2 emissions to zero)
2. Reduce CO2 emissions throughout the Eisai Group to a range absorbable by the nature and achieve virtually zero emissions by 2040
(Reduce Scope 1 and 2 CO2 emissions to zero)

In September 2021, we joined RE100, aninternational initiative that aims to use 100%
renewable energy-derived electricity (RE) for
business activities, and we are accelerating the
adoption of RE. The RE ratio rose to 95.4% in fiscal
2022, and the achievement of 100% RE, originallytargeted for fiscal 2030, is already within sight. In
August 2022, the Eisai Group introduced Internal
Carbon Pricing (see below for details), and is making

capital investments with high environmental value
with a view to reducing Scope 1 emissions. In
addition, we have set our SBT of 1.5°C targets infiscal 2023 and are committed to working towardbuilding a decarbonized society. Through our carbon
neutral initiatives, we will strengthen activities toensure the sustainability of the global environment,
which is the foundation of our business activities.

Roadmap for the achievement of carbon neutrality(tons-CO2)■ Scope 1 (fossil fuels)

CO2 emissions
derived from electric
power

140,000
120,000■Scope 2 (steam)■ Scope 2 (electric power)

100,000
80,000
SBT1.5 goal setting

60,000CO2 emissions derived
from fossil fuels

40,00020,0002021: RE100 membership

0
2016

2018

2020

2022

2024

2026

2028

2030

2032

2034

2036

2038

2040

(Fiscal year)

Use renewable energy certificates, non-fossil fuel certificates, etc., introduce 100% renewable electricity, and introduce in-house photovoltaic power generation (overseas)
Introduce internal carbon pricing and encourage untiring environmental investment
Introduce hybrid vehicles and some electric company vehicles

Switch to fuel cell vehicles, electric vehicles, etc.
Introduce PPA＊SBT (Science Based Targets: targets for reducing greenhouse gas (GHG)
emissions based on scientific grounds)
The Eisai Group has set medium- to long-term
greenhouse gas emission reduction targets shown
below (SBT 2°C target) based on scientific grounds

to help mitigate climate change and is working to
reduce CO2 emissions derived from its businessactivities.

＊ Approved by the Science Based Targets initiative (SBTi), an international NGO (https://sciencebasedtargets.org/)

1. A 30% reduction in GHG emissions (scope 1+2) by fiscal 2030 compared with fiscal 2016
2. A 30% reduction in GHG emissions (Scope 3, Category 1; emissions from purchased products and services) by fiscal 2030
compared with fiscal 2016

In fiscal 2022, our production and R&D activities
in Japan and overseas remained very active, andwere a major factor in the increase in Group-wide
CO2 emissions. On the other hand, the Kawashima
Plant operated its air conditioners in eco-mode,
reducing CO2 emissions by 500 tons. The Suzhou
Plant (China) started using a photovoltaic power
generation system, reducing its CO2 emissions
by 700 tons. In the manufacturing area, setback
operation of heaters, ventilators and air-conditioners
not in operation was introduced, resulting insignificant energy savings and a 310-ton reduction
in CO2 emissions. At the Benxi Plant (China), natural
gas consumption was significantly reduced byusing heat exchangers to prepare warm water. This
has reduced CO2 emissions by 180 tons. We arepromoting the introduction of renewable energyderived electricity (RE) mainly at domestic andoverseas plants and laboratories to contribute to the
reduction of CO2 emissions.
Our sales divisions provide healthcare
professionals with information via remote interviews
using digital devices. Furthermore, we are actively
promoting the use of public transportation and theintroduction of hybrid business vehicles and areworking to reduce fossil fuel consumption.
As a result of the above initiatives, our Scope 1
and 2 emissions in fiscal 2022 were 53,612 tons,
a 28.0% decrease from fiscal 2021. This was a
60.2% decrease from fiscal 2016 (base year) and
our SBT 2°C target (a 30% decrease from the baseyear) has been achieved for the third consecutive
year. We are planning to raise our target to SBT
1.5°C in fiscal 2023 and submitted an application to
the SBTi in March 2023.

New technologies using hydrogen, ammonia, etc. (electricity, heat)＊ PPA: Power Purchase Agreement. An agreement for power purchases that involves consumers’ purchasing and domestically consuming power
through a power grid where electricity is generated from renewable resources by equipment owned by a third party.

9

On the other hand, the method for calculating
Scope 3, Category 1 emissions based on purchased
goods and services has been changed to improve
its accuracy along with setting the SBT 1.5°C
targets, resulting in a significant increase inemissions in fiscal 2022. Going forward, we will
strengthen cooperation with suppliers and establish
a calculation method that better reflects primary data
provided by suppliers. We will strive to reduce Scope
3 emissions in partnership with suppliers.

State of SBT Progress
Trends in Scope (1+2) CO2 Emissions(tons)
Planned emissions
160,000
134,547

120,000

130,752

Emissions results

Trends in Scope (1+2) Cumulative CO2 Emissions(tons)
Planned cumulative CO2 emissions
Cumulative emissions results
1,000,000
908,467

129,487 125,956

122,426

786,041

800,000

660,084

105,286

600,000
79,10980,00074,501
53,61240,000713,551
659,940
585,439
506,330

530,597
401,043

400,000
267,829200,000 134,547

399,845

267,675

134,547

0

2016

2019

2020

2021

2022

0

2016 2017 2018 2019 2020 2021 2022

(Fiscal year)

Scope 3 CO2 Emissions (Category 1)(tons)
800,000

Emissions results(Fiscal year)

Progress in introducing renewable energy
As a company involved in people’s health, the Eisai
Group conducts R&D and production activities inaccordance with GLP (Good Laboratory Practice),
GMP (Good Manufacturing Practice) and other laws,
regulations and guidelines of each country (“Lawsand Regulations”). These Laws and Regulations
require operations under certain temperatureand humidity conditions, consuming enormous
amounts of electricity for air-conditioning and otherpurposes. This is why we consider the reductionof CO2 emissions from power consumption to be
an important issue and actively promoting the
introduction of RE.
So far, the Vizag Site (India) has procured
photovoltaic power, and the Exton Site (UnitedStates) and Kashima Plant have installed photovoltaic
power generation equipment. In fiscal 2022, theSuzhou Plant (China) began operating a large-scale
photovoltaic power generation equipment installed
on-site. The European Knowledge Centre (EKC),
Exton Site, Tsukuba Research Laboratories, andKawashima Plant continue to use 100% RE.
Our plants and offices in China, India, andIndonesia introduced RE through the purchase of
I-RECs (green electricity certificates). Our US offices
also continue to introduce RE through the purchaseof RECs (green electricity certificates valid in the
United States). The Eisai Group in Japan is also
actively promoting the introduction of RE through thepurchase of non-fossil fuel certificates.
As a result of these initiatives, the percentage
of electricity used in the Eisai Group’s businessactivities that is derived from renewable energy
sources increased significantly to 95.4%.

Renewable energy adoption target
target(%)
100

Scope 3 CO2 Emissions (Category 1)/Net Sales(tons/million yen)100

result95.4

80602,655＊

600,000

400,000

430,251456,386

486,07580.0

90521,809
80

75.3

74.6

60

53.9
57.0

70.4

70
200,000

81.0

79.8

63.1

＊

65.6

60

69.0

40
26.8
28.0

20

0

2016

2019

2020

2021

2022

50

2016 2017 2018 2019 2020 2021 2022

(Fiscal year)＊ With the setting of the SBT 1.5°C targets, the calculation method was changed from fiscal 2022.

(Fiscal year)

0

0.6

0.6

2016

2017

4.8

16.0

2018

2019

2020

2021

2022
(Fiscal year)

10CO2 Emissions Breakdown by Sector＊1, ＊2 (Eisai Group, FY2022)

(tons)

RegionScope 1

Scope 2

Total

Japan

23,0005,259

28,259Asia/South America

11,440773

12,213

U.S./Canada

9,823

0

9,823

EMEA

3,245

74

3,319

＊1 Including emissions from vehicles for commercial use in Japan and overseas.
＊2 Including emissions from business activities at offices in Japan and overseas.

CO2 Emissions Breakdown by Departments (Eisai Group, FY2022)

(tons)

Scope 1

Scope 2

Total

Production plants

27,131

4,142

31,272

Research facilities

9,221

1,004

10,225

Offices

822

947

1,769

Warehouses

84

12

96

10,2500

10,250

Vehicles for commercial and other business use

Company Vehicles CO2 Emissions (Trends in Emissions by Region)(t)

FY20187,000

FY2019

6,000

3,000

3,919

3,694
3,026

2,918
2,310 2,516

2,319
2,419

2,000

2,761

FY2022China

Asia/Latin America

2,486
1,295
1,136
1,108

19 16 13 15 9

Japan

U.S.

Eisai Co., Ltd. is also promoting efforts to reduce
CO2 emissions in its sales activities. We havebeen gradually switching our business vehicles tohybrid vehicles (HVs), and in principle, we require
our sales offices to switch to HVs when replacing
their vehicles. In fiscal 2022, the switchover was
accelerated and the introduction rate increased to91.1% (annual average). Eisai Co., Ltd. has also
begun to introduce electric vehicles (EVs), and whenEVs and HVs are combined, 96.0% of our businessvehicles will be eco-friendly vehicles.
CO2 emissions from our business vehicles were1,743 tons, a 7.1% decrease from the previous
year. In addition to encouraging the use of ecofriendly vehicles, we introduced remote interviewing
using digital devices when providing information
to physicians and other healthcare professionals
in an effort to reduce CO2 emissions from the useof vehicles. We will continue to promote the shift
to fuel-efficient vehicles and pursue eco-friendly
business styles to reduce CO2 emissions.

Company Vehicles CO2 Emissions(CO2/t)CO2 emissions

Hybrid vehicle adoption rate (%)

6,000
5,000

91.1
71.5

73.6

73.7

75.2

80

4,000
3,000

60
2,631
2,103

2,000

1,573

1,876

1,743

40
20

1,000
0

100

2018

2019

2020

2021

0
2022 (Fiscal year)

4,205

2,457

2,224

1,918
1,801

1,000
0

FY2021

5,184

5,000
4,000

FY20206,170

Efforts Concerning Company Vehicles (Eisai Co., Ltd.)EMEA

Eisai Co., Ltd. participates in the Keidanren Carbon Neutrality Action Plan through the Federation of
Pharmaceutical Manufacturers’ Association of Japan. The Keidanren’s action plan aims to reduce CO2
emissions from business activities by 46% by fiscal 2030 from the fiscal 2013 level. As a member
organization of the Japan Climate Initiative (JCI), Eisai is aligned with the initiatives to promotedecarbonization and is actively working to combat climate change.
(https://japanclimate.org/member/eisai/).

11

Breakdown of Energy Consumption (FY2022)
Electric power(MWh)Amount used
In Japan

Light oil(kl)

Fuel oil A
(kl)

LPG
(tons)Natural gas(1,000 m3)

LNG(tons)

Processed naturalgas (1,000 m3)

Industrial steam(GJ)

Hot/Cold water(GJ)

1,101.9

31.8

3.2

16.6

19.1

0.0

1,494.3

7,912.8

56,658.1

287.3

1,049,056.9

36,705.8

1,160.4

124.8

647.3

954.8

0.0

81,738.2

316,194.3

57,791.2

390.8

67.9

2.4

0.1

0.0

0.0

0.1

0.0

5.3

20.5

3.7

0.0

Amount used

72,309.3

2,694.9

0.02,148.1

77.6

9.2

6,381.7

0.0

0.6

0.0

0.0

Calorific value (GJ)

720,924.1

89,768.0

0.0

81,712.1

3,018.4

461.6

250,546.0

0.0

24.7

0.0

0.0

62.9

7.8

0.0

7.1

0.3

0.0

21.9

0.0

0.0

0.0

0.0

Amount used

177,530.7

3,796.9

31.8

2,151.3

94.2

28.3

6,381.7

1,494.3

7,913.4

56,658.1

287.3

Calorific value (GJ)

1,769,981.0

126,473.8

1,160.4

81,836.9

3,665.7

1,416.5

250,546.0

81,738.2

316,219.0

57,791.2

390.8

65.8

4.7

0.0

3.0

0.1

0.1

9.3

3.0

11.8

2.1

0.0

Calorific value (GJ)

Ratio (%)

Total

Kerosene(kl)

105,221.4

Ratio (%)

OutsideJapan

Gasoline(kl)

Ratio (%)

Group Companies in Japan CO2 EmissionsCompany name(tons)FY2019FY2020

FY2021

FY2022Eisai Co., Ltd. CO2 Emissions
Operational site

Sunplanet Co., Ltd.

635

550

572

1

EA Pharma Co., Ltd.

9,414

8,663

8,349

5,089

KAN Research Institute, Inc.

2,182

2,043

1,990

1,759

Eisai Logistics Co., Ltd.

3,177

1,839

1,549

96

Bracco-Eisai Co., Ltd.

99

105

101

103

Arteryex

—

—

—

5

Eisai Network Companies in Japan Total

15,507

13,20012,562

7,054

Eisai Group in Japan Total

61,82554,41748,35625,742(tons)FY2019FY2020

FY2021

FY2022

Kawashima Plant

20,532

22,77722,404

10,873

Kashima Plant

7,457

7,905

8,711

3,236

Tsukuba Research Laboratories

16,261

9,216

4,555

4,467

Headquarters office complex

1,348

638

72

69

Communication offices(sales offices in Japan)

681

680

52

42

Honjo Facility

39

—

—

—

46,317

41,21635,794

18,688Eisai Co., Ltd. Total

12

6

Efforts toward the SDGs

Establishment of a Recycling-Oriented Society
Total Waste for the Past Five Fiscal Years

Initiatives for Proper Waste Disposal and Resource Recycling

In addition to achieving zero emissions with the ratioof landfill volume to the volume of waste generated
being 0.5% or less, the Eisai Group in Japan has set
the goal of “reducing the amount of waste generated,
improving the recycling rate, and reducing theamount of waste sent to landfills. As our previous
zero emission target of 1% or less has been achieved
continuously since fiscal 2008, the target was raised
to 0.5% or less in fiscal 2021.
We have also set the target of recycling 50%
or more of our waste, including valuable waste. In
particular, we aim to achieve the target of recycling
80% or more of our plastic waste, taking into accountthe problem of marine plastics.
In fiscal 2021, a relatively large volume of plastic
and metal waste was generated as a result of officerenovations at the head office building. The volumeof the waste returned to normal levels in fiscal 2022,with the total waste generated decreasing by 156 tons

Total Waste and the Ratio of Waste Sent to Landfill to Total Waste
Total waste

Ratio of waste sent to landfill to total waste(tons)

(%)

1.5

6,000

from the previous fiscal year. The volume of recycledmaterials and the volume of recycled valuable materials
decreased by 516 tons and 444 tons, respectively, fromthe previous fiscal year. The recycling rate excluding
valuable materials was 25.3%, down 10.8% from theprevious fiscal year, and the recycling rate including
valuable materials was 45.5%, down 6.9% from theprevious fiscal year, falling short of the target. Landfill
volume was 13.0 tons, an increase of 1.6 tons fromthe previous fiscal year due to an increase in productdisposal, but the landfill rate was 0.31%, achieving zero
emissions for the 16th consecutive year.
The breakdown of waste shows an increase
in alkali waste due to the manufacturing of Active
Pharmaceutical Ingredients (APIs) for anti-ulcerogenic
drugs. Another factor contributing to the increase inwaste generated was the change in counting septictank sludge as general waste beginning fiscal 2022. On
the other hand, plastic and metal waste decreased after

Recycled Waste and Recycling Rate
Amount recycled (including valuables)

Amount recycled (excluding valuables)

Recycling rate (including valuables)(tons)

Recycling rate (excluding valuables)
(%)

60

5,000
53.7

5,000

49.7
4,411

4,000

4,053

3,736

4,000

4,255

3,341

3,000
0.5
0.34

0.34

0.26

2,606

2,000

2,713

2,822

30.1

29.5

36.1

1,000

906

1,005

1,194

2018

2019

2020

2021

0.0

2022 (Fiscal year)

0

2018

2019

2020

FY2022
755
1,544
749
399
95
58
107
548
4,255
1,578
5,833

Waste Plastic Recycling Rate
(%)
100

60

90.5

81.5

80

75.9

74.4

40

0

69.6

Target:
80% or more

74.2

20
2018

Onsite Inspections of Waste-Processing Companies

20

The Eisai Group in Japan outsources the collection,transportation, intermediate treatment, and final
disposal of waste mainly to top-quality industrial
waste disposal companies and periodically conducts
onsite inspections of contractors. In particular, we
ensure the proper disposal of plastic waste, and

1,594
1,078

2021

FY2021
629
1,740
597
485
505
34
134
287
4,411
1,506
5,917

The Eisai Group will continue to dispose of waste
appropriately in compliance with relevant laws andregulations, and further promote waste reduction andrecycling based on the efficient use of resources,
thereby contributing to the formation of a recyclingoriented society.

30

10

0.17

0

FY2020
792
1,597
545
392
147
77
175
328
4,053
1,627
5,680

2019

2020

2021

2022

(Fiscal year)

2,656

25.3

24.3

0.31

1,000

50

the completion of the head office renovation.
With regard to recycling, we actively promoted
the selection of waste disposal contractors that are
more willing to thoroughly separate waste and recycle
resources, the reuse of organic solvents for purposessuch as in chemical synthesis of APIs, and the sale ofwaste solvents for use as auxiliary fuel. In particular,
plastic waste was either thermally recycled or recycled
into raw materials for Refuse Paper and Plastic fuel(RPF). As a result, the volume of plastics recycled by
the Eisai Group in Japan increased by 25 tons fromthe previous year, and the recycling rate reached90.5%, achieving our target. Regarding paper waste,
the use of paper in our offices is also kept to theminimum necessary. In addition to promoting paperless
operations, such as digitization of archived documents,
we also encourage the sale of used paper.

(tons)FY2019
624
1,137
705
311
76
19
172
297
3,341
1,709
5,050

40

3,100

3,000
TargetTarget
45.5

47.9

1.0

2,000

52.4

SludgeWaste oil
Waste acids and alkali
Waste plastic
Scrap metal
Glass and ceramic waste
Industrial waste and other
General waste
Amount of waste generated
Amount soldAmount of waste generated and soldFY2018
900
1,075
790
388
76
21
213
273
3,736
1,699
5,435

0

2022 (Fiscal year)

conduct on-site inspections to prevent marine
pollution and adverse effects on the ecosystem by
microplastics. In fiscal 2022, the Eisai Group in
Japan conducted a total of 45 on-site inspections
including remote inspections.

13

7Management of Chemical Substances
Fiscal 2022 PRTR Data Reported to Authorities (Eisai Group in Japan)

Proper Management of PRTR Substances

Chemical substances used in R&D and the
manufacture of pharmaceutical products include
PRTR substances that may have an impact on theenvironment. The amount of chemical substancesused, released into the environment and transferred
to waste disposal site must be properly monitored.
For this reason, the Eisai Group in Japan uses its
own reagent management system to monitor theuse of reagents and strives to reduce the use of
PRTR substances, and curb their release into theenvironment. When PRTR substance is used in an
amount exceeding the specified amount, it must bereported to the relevant prefectural governments
without delay.
The amounts of chemical substances used in
the manufacturing process depends largely on
the amounts of pharmaceutical products. In thecommercial production stage, however, it is noteasy to change the manufacturing process becauseof the need to maintain quality of the API. For
green sustainable chemistry, we aim to reduce ourenvironmental impact from R&D stage by reducing
the use of chemical substances and developing
synthesis methods using alternative solvents. When
highly volatile PRTR substances are used, we strive
to control their release into the atmosphere as
much as possible and incorporate them into ourmanufacturing processes.
The total amount of PRTR substances used by
the Eisai Group in Japan was 328 tons, a 17%
increase from the previous fiscal year. This was due
to an increase in analytical solvents used for HPLC
analysis, and the manufacture of anti-cancer drugs
and drugs in the neurology and gastrointestinal
fields. We reported eight substances as PRTR
substances, the same as in the previous fiscal year.

Chemical nameSubstanceno.

Number ofoperational
sites

13
53
186
232
277
300
392
411

5
1
2
1
1
1
1
1

Acetonitrile
Ethylbenzene
Dichloromethane (aka methylene chloride)
N, N-dimethylformamide
Triethylamine
TolueneHexaneformaldehyde

Amounthandled63.8795.103
166.786
32.6511.584
42.37511.096
1.530(tons)
ReleaseInto theInto water
atmospherebodies0.091
0.000
18.334
0.000
0.000
0.053
0.120
0.095

0.000
0.000
0.000
0.000
0.000
0.000
0.000
0.000

Transfer
As waste

To sewage

63.7882.107
53.09332.651
1.584
42.322
10.976
0.422

0.000
0.000
0.000
0.000
0.000
0.000
0.000
0.000

Volatile Organic Compounds (VOCs) Release Control
Volatile organic compounds (VOCs) such as ethyl
acetate, acetone, and methanol, which exist
as gasses in the atmosphere, are a source ofphotochemical oxidants along with nitrogen oxides
emitted from factories. In order to prevent air
pollution, we are required to reduce emissions of
VOCs into the atmosphere. Our major plants andlaboratories in Japan are working to reduce theamounts of VOCs used as well as PRTR substances.
At the same time, we have established equipment
operation methods to minimize emissions from ourprocesses.

The figure below shows changes over time in
the volume of 55 of the 100 major VOCs specified
by the Ministry of the Environment, excluding PRTR
substances, used at the plants and laboratories
of Eisai Group in Japan and released into theatmosphere. In fiscal 2022, the Eisai Group in Japan
used 1,114 tons of VOCs, about the same amountas in the previous year. Due to measures taken atplants and research laboratories, emissions into theatmosphere were kept at 37.1 tons (3.3% of thetotal amount of VOCs handled).

Actual Use of Substances Subject to the PRTR System
Amount handled(tons)
400

Amount released

Amount transferred

Amount of VOCs Released from Production Plants and Research Laboratories in Japan359(tons)
1,500

328
300

261

280

264
228

200

157

1,168

1,127

226

210

1,000

Amount released into the atmosphere

1,114

1,093

964

144

500

100
16
0

Amount handled

2018

19
2019

26
2020

10
2021

19
2022 (Fiscal year)

0

18

24

28

24

2018

2019

2020

2021

38
2022 (Fiscal year)

14

Efforts toward the SDGs

Management of Fluorocarbons

8

Efforts toward the SDGs

Saving Resources

Effective Use of Water Resources

The Eisai Group in Japan is systematicallyeliminating and replacing equipment that uses
chlorofluorocarbons (CFCs) with equipment thatuses hydrofluorocarbons (HFCs) or non-fluorocarbon
refrigerants, which do not deplete the ozone layer.
Because CFCs have a strong greenhouse effect,
we regularly inspect our equipment to prevent
leakage, and in the unlikely event of a leak, we
promptly share information and take action toprevent recurrences. At the time of equipment

disposal, we ensure that all fluorocarbons have been
properly collected, destroyed, and disposed of, andobtains a disposal certificate from the contractors.
Based on the Act on Rational Use and Appropriate
Management of Fluorocarbons, our fiscal 2022
emissions of fluorocarbons were 327 t-CO2. Thisis the seventh consecutive year since the Act tookeffect that our emissions have been below thethreshold (i.e., 1,000 t-CO2) to be reported to the
Ministry of Health, Labour and Welfare.

Sufficiently securing water resources is essential
for pharmaceutical research and manufacture.
The Eisai Group reviewed the water withdrawal inareas experiencing water stress, utilizing the “Think
Hazard” database and the World Resources Institute(WRI) Aqueduct. In addition, the Group conducted anawareness survey of its plants and laboratories basedon a mid-term forecast of our business activities. As
a result, no water withdrawal was identified in areas
currently considered high-risk. Meanwhile, as a midterm goal, the Eisai Group as a whole has set a target

to reduce water consumption by 7% (intensity per
sales) from the fiscal 2023 level by fiscal 2030, andis encouraging the efficient use of water resources,
including the recycling of waste water from researchfacilities and rainwater harvesting. Furthermore, wehave set mid-term goal of maintaining zero violationsof laws by fiscal 2030 in compliance with wastewaterrelated environmental standards of each country, andwe maintain high-quality wastewater treatment tocontribute to preservation of water quality.

Eisai Group Water Consumption and Amount of Wastewater
Changes in calculated fluorocarbon leakage amount(t-CO2)

Calculated leakage amount of fluorocarbons

800(1,000m3)

Water consumption

4,000
3,525

3,478
600

3,000

553

508
400

3,092

621

Amount of wastewater

3,863
3,220
2,886

2,906

2,923
2,591

2,556

2,000

385
327

321

1,000

200

0

5

0
2016

2017

2018

2019

2020

2021

2018

2019

2020

2021

2022 (Fiscal year)

2022 (Fiscal year)＊ Received an A rating in the second assessment survey on compliance with “Act on Rational Use and Appropriate Management of Fluorocarbons”
by the Japan Refrigerants and Environment Conservation Organization (JRECO).

Green Purchasing
The Eisai Group in Japan promotes "green
purchasing" as an environmental initiative that
employees take on a daily basis, purchasing only what
they need and giving priority to more environmentallyfriendly products if they are of comparable quality andprice. Through this initiative, we aim to break awayfrom a society of mass-production, mass-consumption and mass-waste. Eisai Co., Ltd., inparticular, has been actively committed to thisinitiative through participation in the Green Purchasing
Network＊ and in accordance with its own Green
Purchasing Guidelines.
＊ A network of companies, local governments and consumer groups(private organizations) supporting the concept of green purchasing.

15

9

Efforts toward the SDGs

Biodiversity Conservation

Map of relationships between Eisai's business and biodiversity

Setting mid-term biodiversity targets

The 15th Conference of the Parties to theConvention on Biological Diversity (COP 15) was
held in Montreal, Canada in December 2022.
COP15 adopted the 30 by 30 goal of conserving
at least 30% of continental and marine areas by2030. COP15 also called for companies to assess
the impact of their operations on biodiversity andpromote conservation activities.
The Eisai Group established the Biodiversity
Guidelines in August 2020 to promote conservationof biodiversity. The ENW Environmental Policy,
revised in April 2021, states that we will conduct ourbusiness activities in consideration of biodiversity
conservation in order to contribute to the realizationof a society in harmony with nature. We strive to

The Eisai Group has set the following mid-termtargets to contribute to the conservation of
biodiversity. In addition to existing initiatives, we will

understand the impact on biodiversity at each stageof our business activities and implement biodiversity
conservation activities.
In fiscal 2022, we surveyed the relationshipbetween our business and biodiversity with reference
to “The Business and Biodiversity Interrelationship
Map®” created by the Japan Business Initiative for
Biodiversity (JBIB) to understand how our businessactivities depend on and impact biodiversity. (See thefigure below.)
As a result, we do not believe that there are
any risks that threaten biodiversity in our businessactivities at this time. However, we have identified
the following two long-term risks:

1. Impact on biodiversity in surrounding areas due to emissions of hazardous substances into the waterand air at operating sites
2. Environmental impact of waste generated from product use (e.g., marine plastic problem)

undertake new activities to reduce the impact of ourbusiness activities on biodiversity.

FY2025
Each ENW and business site will identify at least one important species in the vicinity of their operating site
and implement conservation activities (at least 10 of the 13 major operation sites).
FY2030
1. All major operating sites have initiated conservation activities for important species in the vicinity of theirsites, and species are being preserved and maintained at 7 or more sites.
2. Introduced eco-friendly materials for product packaging, etc. (introduced in several product items)＊Major manufacturing and research sites are as follows:
Kawashima Plant, Tsukuba Research Laboratories, Kashima Plant, EA Pharma Fukushima Plant, KAN Research Institute, Suzhou Plant (China),
Benxi Plant (China), Bogor Plant (Indonesia), Vizag Site (India), European Knowledge Center (UK), Exton Site (U.S.), Baltimore Plant (U.S.), G2D2 (U.S.)

Major initiatives in Japan and overseas
Since the Kawashima Plant began operations inMarch 1966, it has been working to preserve
the natural environment within the plant under
the concept of “All for Patients and Nature.”
The Kawashima Plant’s greenery coverage isapproximately 50% of the approximately 470,000
m2 site area, and approximately 30,000 trees,
including Japanese black pines, are maintained
and managed. Furthermore, the Medicinal Herbal
Garden at the Naito Museum of Pharmaceutical
Science and Industry, located within the Kawashima
Plant, cultivates and conserves about 700 kinds

Some of the endangered species protected in the Medicinal Harbal
Garden (Left: Gomanohagusa, right: Kotoukan mallow)

of medicinal and beneficial plants. In particular,
we protect 38 of the threatened species (includingnear threatened species) on the Ministry of theEnvironment’s Red List. In fiscal 2022, we assisted
the propagation of five of these species.
In addition, the Kashima Plant is systematicallymanaging greenery and planting more trees on
the premises. Furthermore, the Vizag Site (India)
continues its tree-planting program on World
Environment Day in June to raise environmental
awareness among employees. In fiscal 2022, 2,000
trees were planted on the premises of the plant.

Tree planting (left: Kashima Plant, right: Vizag Site)

16

10

Soot
and dust 2020＊

SOx 2020

2022

0.6

0

2021
2022

0.0
0.1

20

30

0

40 (tons)

3

4

5

6

7

2018

13.3

2019

11.0

BOD 2020

6.8

2021

Air Pollutant Emissions in Fiscal 2022 by Sites

10

20

5.6

2022

2018

10.1

2019

9.9

19.8

2019

NOx 2020

10.8

17.5

Nitrogen 2020

2021

8.0

23.3

2021

12.2

2022

13.8

Soot
and dust 2020

0.4

2022

0.6

0

Phosphorus 2020

5.3

0.6

2021

2019

5.8

0.5

＊

2018

6.9

0.4

2019

1

40

50

60 (tons)

5.9

26.5

3.8

2021

3.6

2022

2

3

4

5

6

7

Category

4.2

36.0

1.0
2.4
1.6
2.4
2.9
2.9
1.5
3.2
0.9
2.6

8

Soot anddust (kg)

105

8,550

331

–

2,685

212

0.03

438

15

105

11,673558

Exton Site

3

157

6

Vizag Site

4,453

10,691

3,226
148

–

292

1,083

812

–

83

1,816

212

Subtotal

5,623

13,768

3,592

Total

5,727

25,4414,150

Note: “–” indicates that no measurement was taken.

Pollutant Load in Wastewater in Fiscal 2022 by Sites
Category

0.2

0.1
0.1
0.0
0.1
0.1
0.1

Operational site/Company

2

COD
(kg)

Nitrogen Phosphorus
(kg)
(kg)

2,822

–

2,467

Tsukuba Research Laboratories

3,172

–

–

–

765

500

–

–

34

–

84

51

32

–

–

–

Subtotal

6,825

500

2,551

113

Exton Site

59

–

26

10

–

–

–

113
21

KAN Research Institute

1

BOD
(kg)

Kawashima Plant
Eisai group Kashima Plant
in Japan EA Pharma Fukushima Plant

0.2
0.1

0

NOx (kg)

Kawashima Plant

Group
Suzhou Plant
companies
outside Japan Baltimore Plant
Benxi Plant

33.3

0.3

SOx (kg)

Eisai group in Tsukuba Research LaboratoriesJapan
EA Pharma Fukushima Plant
46.9

6.8

6.8

Operational site/Company

Subtotal■Magnified scale■Magnified scale

2018

30

18.4

9.2

11.7

8

(Fiscal year)

2018

2022

2

■Eisai group in Japan ■Group companies outside Japan

14.8

0.2

0.1

3.6

1

Pollutant Load in Wastewater
10

0.1

3.8

0.4

Air Pollutant Emissions and Pollutant Load in Wastewater(Fiscal year)

2019

5.3

0.6

2021

■Group companies outside Japan

0
2018

5.8

0.5

＊

Air Pollutant Emissions■Eisai group in Japan

0.4

2019

Group
Suzhou Plant
companies
Benxi Plant
outside＊Vizag Site
Japan

62

451

–

203

32,76685,929720–

Subtotal

33,27685,929

948

144

Total

40,10186,4293,499

257＊After undergoing secondary treatment in the external wastewater treatment plant, it isdischarged into the sea as safe wastewater.
Note: “–” indicates that no measurement was taken.

■Eisai group in Japan0(Fiscal year)■Group companies outside Japan

10

20

30

40

50

60 (tons)

17

11

Resource Input and Environmental Impact (Eisai Group in Japan)

Kawashima Plant

(FY)
2020

2021

2022

Purchased electricity (MWh)32,37435,27941,101

Processed natural gas (tons)

5,524

5,447

5,328

1

1

1

Amount generated (tons)

812

1,164

1,260

Recycled amount (tons)

412

198

Amount sent to landfill (tons)

0.1

0.1

(FY)

EA Pharma Co., Ltd., Fukushima Plant

2020

2021

2022

Purchased electricity (MWh)23,94725,007

25,136

Purchased electricity (MWh)Processed natural gas (tons)

2,041

2,205

2,166

Liquefied petroleum gas (LPG) (tons)

0

20

16

Liquefied natural gas (LNG) (tons)

Amount generated (tons)

288

246

256

154

Recycled amount (tons)

125

61

0.1

Amount sent to landfill (tons)

7.3

1.3

Energy consumption

Liquefied petroleum gas (LPG) (tons)

Tsukuba Research Laboratories

Waste treatment

Air pollutant emissions and pollutant load in wastewater

2022

1.8

2.3

1.3

Acetonitrile (tons)

3.8

4.6

3.6

Dichloromethane (tons)

0.6

0.6

0.5

Hexane (tons)

0.1

0.1

0.1

Acetonitrile (tons)

51.3

63.1

56.7

Ethylbenzene (tons)

3.6

4.1

5.1

Triethylamine (tons)

1.2

2.2

1.6

0.0

Dichloromethane (tons)

191.5

66.4

131.8

9,012

8,536

8,935

6

8

9

1,508

1,468

1,494

Amount generated (tons)

370

340

479

102

Recycled amount (tons)

122

132

147

1.4

Amount sent to landfill (tons)

0.3

0.4

3.3

Kawashima Plant

Energy consumption

Waste treatment

Air pollutant emissions and pollutant load in wastewater

Air pollutant emissions and pollutant load in wastewaterSOx (kg)

131

49

105

SOx (kg)–––

SOx (kg)NOx (kg)

7,498

3,945

8,550

NOx (kg)

400

131

331

Water consumption (1,000 m3)＊

2,733

2,436

Wastewater discharge (1,000 m3)＊

2,317

BOD (kg)

(FY)

2021

2022

Waste treatment

Principal PRTR Substances Handled
2020

2021

Energy consumption

Fuel oil A (kl)

(FY)

2020

0.0

0.0

Acetonitrile (tons)
Tsukuba Research Laboratories

Kashima Plant

2,503

3,536

2,685

NOx (kg)

774

542

438

N, N-dimethylformamide (tons)

33.1

41.1

32.7

Soot and dust (kg)

182

230

212

Soot and dust (kg)

17.2

59.6

14.7

Toluene (tons)

43.5

48.1

42.4

3,027

Water consumption (1,000 m3)

180

203

213

Water consumption (1,000 m3)

72

72

71

Formaldehyde (tons)

1.0

1.3

1.5

2,331

1,933

Recycled water (1,000 m3)

81

83

80

Wastewater discharge (1,000 m3)

39

38

36

Hexane (tons)

0.2

9.4

11.1

4,172

4,767

2,822

Wastewater discharge (1,000 m3)

Nitrogen (kg)

2,794

3,071

2,467

BOD (kg)

Phosphorus (kg)

44

51

62

Soot and dust (kg)＊ At the Kawashima Plant, groundwater was pumped up
and discharged as the source of regional rivers based on arequest from the local government and the relevant figures arelisted. The actual amount of water used in the manufacturing
process and the amount of wastewater were both 177,521 m3(as of FY2022).

165

203

213

BOD (kg)

55

41

34

EA Pharma Co., Ltd., Fukushima Plant

1,367

3,052

3,172

Nitrogen (kg)

100

87

84

Acetonitrile (tons)

0.7

0.9

1.1

Nitrogen (kg)

0

0

0

Phosphorus (kg)

31

25

51

Dichloromethane (tons)

20.4

31.9

35.0

Phosphorus (kg)

0

0

0

2021

2022

“–” Unmeasured

Principal VOC Substances Handled

Kashima Plant

(FY)
2020

2021

2022

Purchased electricity (MWh)14,838

16,671

16,937

Industrial steam (GJ)

54,26162,01656,6586

7

6

Energy consumption

Liquefied petroleum gas (LPG) (tons)

Amount generated (tons)

1,715

1,612

1,691

Recycled amount (tons)

484

434

364

0

0.2

0

Air pollutant emissions and pollutant load in wastewater

2020

(FY)
2020

2021

2022

Purchased electricity (MWh)

3,319

3,259

3,281

Processed natural gas (tons)

375

361

370

Energy consumption

Waste treatment

Amount sent to landfill (tons)

KAN Research Institute, Inc.

Waste treatment
Amount generated (tons)

44

40

53

Recycled amount (tons)

10

7

23

Amount sent to landfill (tons)

0.7

0.7

0.8

Air pollutant emissions and pollutant load in wastewater(FY)

Kawashima Plant
Methanol (tons)

1.6

−

1.2

Ethanol (tons)

7.9

5.7

16.0

Ethyl acetate (tons)

3.7

3.0

3.0

Methanol (tons)

4.5

4.1

4.9

Heptane (tons)

2.1

2.0

2.0

Ethanol (tons)

2.6

4.1

2.0

Tsukuba Research Laboratories

Kashima Plant
Ethyl acetate (tons)

192.1

143.7

190.7

SOx (kg)–––

Methanol (tons)

433.8

455.2

399.4

SOx (kg)–––NOx (kg)–––

Methyl ethyl ketone (tons)

4.8

2.9

3.5

NOx (kg)–––

Soot and dust (kg)

–

–

–

Isopropanol (tons)

14.5

18.1

15.1

Soot and dust (kg)

–

–

–

Water consumption (1,000 m3)

12

12

12

Acetone (tons)

324.4

208.4

289.7

Water consumption (1,000 m3)

53

57

57

Wastewater discharge (1,000 m3)

12

12

11

Heptane (tons)

63.3

76.2

73.9

Wastewater discharge (1,000 m3)

53

55

51

BOD (kg)

18

19

32

Ethanol (tons)

52.7

27.8

46.2

1,165

1,317

765

Nitrogen (kg)

0

0

0

Tetrahydrofuran (tons)

32.9

97.0

38.1

Nitrogen (kg)

0

0

0

Phosphorus (kg)

0

0

0

Propanol (tons)

3.8

4.3

3.5

Phosphorus (kg)

0

0

0

“–” Unmeasured

Methanol (tons)

17.8

19.4

20.6

Isopropanol (tons)

4.5

4.5

4.0

BOD (kg)“–” Unmeasured

EA Pharma Co., Ltd. Fukushima Plant

18

12

Resource Input and Environmental Impact(Group Companies outside Japan)

Eisai China Inc., Suzhou Plant (Jiangsu, China)
Energy consumption
Purchased electricity (MWh)Natural gas (1,000 m3)
Waste treatment
Amount generated (tons)
Recycled amount (tons)
Amount incinerated (tons)
Air pollutant emissions
SOx (kg)NOx (kg)
Soot and dust (kg)
Pollutant load in wastewater
Water consumption (1,000 m3)
Wastewater discharge (1,000 m3)
Phosphorus (kg)

2020

2021

(FY)
2022

17,237
1,485

18,665
1,609

17,414
1,554

484
374
110

526
417
109

498
395
103

304
37
216

521
334
728

0
291.8
147.6

147
115
29

159
126
17

155
124
113

Eisai (Liaoning) Pharmaceutical Co., Ltd., Benxi Plant (Liaoning, China) (FY)2020
Energy consumption
Purchased electricity (MWh)Natural gas (1,000 m3)
Light oil (kl)Waste treatment
Amount generated (tons)
Recycled amount (tons)
Amount sent to landfill (tons)
Air pollutant emissions
SOx (kg)NOx (kg)
Soot and dust (kg)
Pollutant load in wastewater
Water consumption (1,000 m3)
Wastewater discharge (1,000 m3)
BOD (kg)
Nitrogen (kg)
Phosphorus (kg)

2021

3,964
926
1

2022

4,005
878
1

4,629
920
1

72
22
42

94
37
29

292
19
48

546
1,997
239

141
1,416
187

83
1,816
212

54
54
825
858
26

45
33
303
529
13

53
45
451
203
21

PT Eisai Indonesia, Bogor Plant (West Java, Indonesia) (FY)2020
Energy consumption
Purchased electricity (MWh)Light oil (kl)Liquefied petroleum gas (LPG) (tons)
Waste treatment
Amount generated (tons)
Recycled amount (tons)
Amount sent to landfill (tons)
Pollutant load in wastewater
Water consumption (1,000 m3)
Wastewater discharge (1,000 m3)
BOD (kg)
Nitrogen (kg)

2021

2022

947
1
0.02

1,021
2
0.04

994
1
0.01

4
4
0

5
−
0

4
−
0

8.6
8.2
7
1.3

5.2
5.2
13
3.5

4.5
4.5
11.2
18.1

Vizag Site (Andhra Pradesh, India)
Energy consumption
Purchased electricity (MWh)Light oil (kl)Liquefied petroleum gas (LPG) (tons)
Waste treatment
Amount generated (tons)
Recycled amount (m3)Amount sent to landfill (kg)Sold (Indian rupees)
Air pollutant emissions
SOx (kg)NOx (kg)
Soot and dust (kg)
Pollutant load in wastewater
Water consumption (1,000 m3)
Wastewater discharge (1,000 m3)
COD (kg)
BOD (kg)
Nitrogen (kg)

2020

2021

(FY)
2022

17,2611,459
10

17,7931,333
1015,866
1,612
9

363
402
557
336
344
505
100
1,130
880
221,699 2,219,025 5,551,886
8,397
13,564
5,019

5,454
9,572
3,658

4,453
10,691
3,226

135
55
108,104
34,628769

142
50
103,743
35,342938

120
4185,92932,766720

European Knowledge Centre (Hertfordshire, U.K.)

(FY)
2022

2020
Energy consumption
Purchased electricity (MWh)Natural gas (1,000 m3)
Liquefied petroleum gas (LPG) (kl)Waste treatment
Amount generated (tons)
Recycled amount (tons)
Amount sent to landfill (tons)
Pollutant load in wastewater
Water consumption (1,000 m3)
Wastewater discharge (1,000 m3)

2021

6,938
944
0

7,652
1,003
0

8,025
961
0

263
263
0

247
247
0

255
255
0

22
22

22
21

Exton Site (United States)
Energy consumption
Purchased electricity (MWh) Note
Natural gas (deca-therms)＊
Light oil (kl)Waste treatment
Amount generated (tons)
Recycled amount (tons)
Amount sent to landfill (tons)
Air pollutant emissions
SOx (kg)NOx (kg)
Soot and dust (kg)
Pollutant load in wastewater
Water consumption (1,000 m3)
Wastewater discharge (1,000 m3)
BOD (kg)
Nitrogen (kg)
Phosphorus (kg)

24
24

2020

2021

(FY)
2022

9,244
51,442
21

9,639
49,7078

9,460
68,753
9

119
27
74

118
29
72

113
32
68

4
218
9

4
208
8

3
157
6

31
14
11,406
1,268
85

27
9
401
36
14

26
8
59
26
10

H3 Biomedicine Inc. (Massachusetts, U.S.)
2020
Energy consumption
Purchased electricity (MWh)Natural gas (deca-therms)＊
Waste treatment Note
Amount generated (tons)
Recycled amount (tons)
Amount sent to landfill (tons)
Pollutant load in wastewater
Water consumption (1,000 m3)
Wastewater discharge (1,000 m3)

2021

3,993
9,362

2,968
7,586

2,094
4,480

7
4
69

10
4
77

13
3
153

6.1
6.1

7.7
7.7

2.7
2.7

Eisai Inc., Baltimore Plant (Maryland, U.S.)
Energy consumption
Purchased electricity (MWh)Natural gas (deca-therms)＊
Waste treatment
Amount generated (tons)
Recycled amount (tons)
Amount sent to landfill (tons)
Air pollutant emissions
Sox (kg)NOx (kg)
Pollutant load in wastewater
Water consumption (1,000 m3)
Wastewater discharge (1,000 m3)

2020

2021

(FY)
2022

5,519
17,141

5,622
17,257

5,426
17,141

16
4
9

18
4
10

16
4
9

2,056
1,721

1,224
969

1,083
812

8.2
8.2

7.4
7.4

8.8
8.8

G2D2 (Maryland, U.S.)
2020
Energy consumption
Purchased electricity (MWh)Natural gas (deca-therms)＊
Waste treatment
Amount generated (tons)
Recycled amount (tons)

(FY)
2022

2021

(FY)
2022

737
335

916
306

1,041
345

30
9

37
21

34
18

Principal Chemical Substances Used
2020
Suzhou Plant
Ethanol (tons)
Methanol (tons)
Acetonitrile (tons)
Benxi Plant
Ethanol (tons)
Methanol (tons)
Ether (tons)
Sodium hydroxide (tons)
Hydrochloric acid (tons)
Bogor Plant
Methanol (l)Acetonitrile (l)Anhydrous ethanol (l)Glacial acetic acid (l)the Vizag Site
Acetone (tons)
Methanol (tons)
Ethanol (tons)
n-heptane (tons)
Tetrahydrofuran (tons)
Dimethyl sulfoxide (tons)
N, N-dimethylformamide (tons)
N, N-dimethylformamide (tons, reused)Dichloromethane (tons)
Sodium methoxide (tons)
Concentrated hydrochloric acid (tons)
European Knowledge Centre
Acetonitrile (tons)
Methanol (tons)
Ethanol (tons)
Exton Site
Decon Quat 100 (quaternary ammonium solution) (kl)Decon Spore 200 plus (kl)Decon Clean (residual remover) (kl)Anhydrous crystalline glucose (tons)
Sodium hydroxide (tons)
H3 Biomedicine Inc.
Acetonitrile (tons)
Dichloromethane (tons)
Ethyl acetate (tons)
Hexane (tons)
Methanol (tons)
Baltimore Plant
Dichloromethane (kg)Petroleum ether (kg)Anhydrous acetate (kg)Anhydrous ether (kg)G2D2
Acetonitrile (kl)Ethyl acetate (kl)Heptane (kl)Methyl-tert-butyl ether (kl)

2021

(FY)
2022

30.1
0.8
0.6

37.5
0.8
0.8

47.1
0.7
0.7

4.5
−
−
0.6
0.5

8.7
−
−
0.9
0.8

8.3
−
−
0.6
1.0

236
170
3.8
8.0

240
115
2.5
6.0

304
80
2.5
−

24.8
446.8
238.2
14.1
78.4
6.9
47.5
16.0
8.8
6.3
64.8

14.5
539.2
78.1
5.6
80.8
15.3
35.1
49.9
4.0
13.8
63.2

10.6
333.3
126.4
1.9
32.4
6.3
28.4
42.4
3.0
5.1
43.4

−
0.3
0.2

0.5
0.4
0.1

0.4
0.3
0.1

3.3
0.5
0.3
0.3
0.7

3.3
0.8
0.8
0.4
0.6

4.4
1.4
1.4
−
0.7

0.6
0.2
0.2
0.1
0.2

0.9
0.4
0.4
0.3
0.4

0.6
0.4
0.5
0.3
0.4

314
156
91
44

323
122
58
33

279
80
25
21

2.0
3.1
1.1
1.2

1.7
1.2
1.1
1.0

1.7
1.2
1.1
1.0

＊ One deca-therm = 1,055 MJ
Note: “–” Unmeasured

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13

Third-Party Verification

Eisai Co., Ltd. undergoes third-party inspections of GHG emissions, water intake and wastewater discharge, and waste generation
at its 14 major production and research sites* in Japan and overseas. The inspection of GHG emissions covers Scope 1, 2, and 3(Category 1) emissions, which are SBT2°C reduction targets.
The Eisai Group reviewed water withdrawal in areas where water stress is occurring, utilizing the Think Hazard database andthe World Resources Institute (WRI) Aqueduct. The Group also conducted an awareness survey of its plants and laboratories basedon mid-term forecast of our business activities. As a result, we did not identify any water withdrawals in areas that are currently
considered to have high risks of water stress. Going forward, Eisai will continue to appropriately monitor and promote sustainable
efforts to conserve water resources at each of our business sites.
The amount of waste generated is confirmed to not have an excessive burden on the environment compared to other companies
in the same industry.

●Environmental impact data in fiscal 2022 from 14 of our major sites* in Japan andoverseas
Greenhouse gas emissions Scope1: 36,417 t-CO2 Scope2: 5,039 t-CO2 Scope3(Category1): 602,655 t-CO2
Water intake: 3,777 (1,000 m3) Water discharge: 2,505 (1,000 m3)
Amount of waste generated: 5,522 t(Verification period: April 1, 2022 – March 31, 2023)＊ As for GHG emissions, 15 sites including the head office undergo inspections.

The assurance report can be viewed on our website.
https://www.eisai.co.jp/sustainability/management/pdf/esg_index.pdf

20

14

Sustainability-Related
Indicators

As an indicator of sustainability, we calculated the relationship between the environmental impact
accompanying business activities and management indicators in working toward the formation of asustainable society. Along with the increase in numerical values, we believe we are carrying out businessactivities with even higher sustainability in terms of environmental aspects.
Energy Productivity ＊1

Waste Productivity ＊2(million yen/MWh)(hundred million yen/t)

1.29

1.3

1.6
1.52

1.21
1.2
1.4

1.1

1.35
1.30

1.07

1.0
0.90

0.98

2018

2019

1.23
1.2
1.19

0.9
0.8

2020

2021

2022

1.0

2018

2019

2020

2021

(Fiscal year)

2022(Fiscal year)＊1 Net sales (million yen)/amount of energy used (MWh).

＊2 Net sales (hundred million yen)/amount of waste generated (tons).

GHG Productivity ＊3

Water Productivity ＊4(million yen/tons)(hundred million yen/thousand m3)

13.88

14.0

2.5

12.0

2.35
2.08

2.00

2.0

10.0
8.17

10.15

1.93

1.83

8.0
1.5
6.0
4.0

4.82

6.61

2018

2019

2020

2021

2022
(Fiscal year)＊3 Net sales (million yen)/amount of CO2 emissions (tons).

1.0

2018

2019

2020

2021

2022
(Fiscal year)＊4 Net sales (hundred million yen)/amount of water resources input(thousand m3).

21