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placental thyroid hormone transport. Maternal hypothyroidism did not alter placental and fetal growth, or cause alterations in fetal pituitary-thyroid axis expression of thyroid hormone receptor isoforms. However, maternal hypothyroidism significantly increased expression of Twist and Chst5 in maternal long bones and fetal ribs. These genes are critical to control tissue architecture during embryonicdevelopment. In contrast to Twist and Chst5, Fgf2 and Fgf7 expression was not altered in maternal long bones or fetal ribs by maternal hypothyroidism. Maternal hypothyroidism was also associated with an increase in expression of Runx2 and suppression of Osterix expression in maternal long bones and fetal ribs. These results provide further evidence that maternal hypothyroidism leads to alterations
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Bria Softphone Download VERIFIED Crack 14