1-P1-01 Poster Sessions
BARP regulates the dynamics of voltage-dependent Ca2+ channel
complexes at dendritic spine
Yoshihiro Matsunaga1, Akito Nakao1, Mizuki Omori1, Taketoshi Kajimoto1,2, Yasuo Mori1
1

Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ., 2Div. Biochem. Kobe Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society

1-P1-02 Poster Sessions
Presynaptic inhibition of GABA release from striatal medium spiny neurons
onto cholinergic interneurons in young-adult mice.
Etsuko Suzuki, Toshihiko Momiyama
Department of pharmacology, Jikei university school of medicine

Copyright © The Japanese Pharmacological Society

1-P1-03 Poster Sessions
Involvement of NO cascade in AT1 receptor mediated effects of angiotensin II
on excitatory synaptic transmission in the rat nucleus tractus.
Yoshiaki Ohi, Daisuke Kodama, Akira Haji
Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.

Copyright © The Japanese Pharmacological Society

1-P1-04 Poster Sessions
Evaluation of the effect of levetiracetam on methamphetamine-induced
L174Q
rats
hyperactivity in Sv2a
Saki Shimizu, Yui Mimaki, Sayaka Jinno, Shiho Taruya, Tadao Serikawa, Yukihiro Ohno
Dept. Pharmacol., Osaka Univ. Pharm. Sci.

Copyright © The Japanese Pharmacological Society

1-P1-05 Poster Sessions
Effect of estradiol on behavioral selection for pups and synaptictransmission in the rhomboid nucleus of the bed nucleus of the stria
terminalis
Kiyoshiro Fukui, Keiichiro Sato, Masabumi Minami, Taiju Amano
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan

Copyright © The Japanese Pharmacological Society

1-P1-06 Poster Sessions
Lysophosphatidylethanolamines with different fatty acid lengths stimulate
neurite outgrowth in cultured cortical neurons through distinct signalingcascadesYoshida Hironori1,3, Kazutoshi Hisano2,3, Shiori Kawase4, Tetsuhiko Mimura2,3, Hisao Haniu3,
Tamotsu Tsukahara5, Taiga Kurihara6, Yoshikazu Matsuda7, Naoto Saito3, Takeshi Uemura3,4
1

Grad. Sch. of Sci.
Tech., Shinshu Univ., Nagano, Japan, 2Grad. Sch. of Med., Sci.
Tech., Shinshu Univ.,
3
4
Nagano, Japan, IBS-ICCER., Shinshu Univ., Nagano, Japan, Div. of Gene Res., Res. Cent. for Supports to
Advanced Sci., Shinshu Univ., Nagano, Japan, 5Dept. Pharmcol. Therap. Innov., Nagasaki Univ., inst. Biomed. Sci.,
Nagasaki, Japan, 6Div. Microbiol. & Mol. Cell. Biol., Nihon Pharmaceutical Univ., Saitama, Japan, 7Div. of Clin.
Pharm. & Pharmaceut., Nihon Pharmaceutical Univ., Saitama, Japan

Copyright © The Japanese Pharmacological Society

1-P1-07 Poster Sessions
Alteration of parvalbumin expression and perineuronal nets formation in theanterior cingulate cortex of Fabp3 KO mice
Yui Yamamoto1,2, Yuji Owada2, Kohji Fukunaga3, Keiju Kamijo1
1

Dept. Anatomy, Tohoku Med. and Pharm. Univ.,2Dept. Organ Anatomy, Tohoku Univ. Grad. Sch. Med.,3Dept.
Pharmacology, Tohoku Univ. Grad. Sch. Pharm.

Copyright © The Japanese Pharmacological Society

1-P1-08 Poster Sessions
E3 Ubiquitin Ligase HRD1 regulates the Serotonin Transporter Function
Taguchi Kei1, Masayuki Kaneko3, Serika Motoike2, Kana Harada1, Izumi Hide1, Shigeru Tanaka1,
Norio Sakai1
1

Department of Molecular and Pharmacological Neuroscience, 2Department of Dental Anesthesiology Graduate
School of Biomedical and Health Sciences, Hiroshima University, 3Department of Pharmacology and Therapeutic
Innovation, Nagasaki University Graduate School of Biomedical Sciences

Copyright © The Japanese Pharmacological Society

1-P1-09 Poster Sessions
Regulation of nicotine-induced tremor by the dopaminergic nervous system
Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Chihiro Takashima, Kana Tsujimura,Kazuya Horikawa, Yukihiro Ohno
Dept. Pharmacol., Osaka Univ. Pharm. Sci.

Copyright © The Japanese Pharmacological Society

1-P1-10

Poster Sessions
2+

2+

Applying Ca Image Sensor to visualize extracellular Ca dynamics inhippocampus.
Parajuli Bijay1, Hideo Doi3, Eiji Shigetomi1,2, Youichi Shinozaki1,2, Toshihiko Noda3,4,
Kazuhiro Takahashi3, Kazuaki Sawada3, Schuichi Koizumi1,2
1

1Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi,
Yamanashi, Japan, 2Yamanashi Interdisciplinary Brain-Immune Research Center (YiBIC), University of Yamanashi,
Yamanashi, Japan, 3Integrated Biosensor. MEMS group, Department of Electrical and Electronic Information
Engineering,, 4Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) Toyohashi University ofTechnology

Copyright © The Japanese Pharmacological Society

1-P1-11 Poster Sessions
Human excitatory amino acid transporters (EAATs) were functional in thehuman induced pluripotent stem cell (hiPSC)-derived human neuralnetworks
Kanako Takahashi1, Kaori Chujo1, Ikuro Suzuki2, Kaoru Sato1
1

Lab. Neuropharmacol., Div. Pharm., Nat. Inst. Hlth. Sci.,, 2Dept. Electro., Grad. Sch. Engineering, Tohoku Inst.
Tech.,

Copyright © The Japanese Pharmacological Society

1-P1-12 Poster Sessions
Expanding the repertoire of the genetically-encoded fluorescent transmitter
sensors
Daisuke Ino
Dept. Cell Biol Histol., Grad. Sch. Med., Kanazawa Univ.

Copyright © The Japanese Pharmacological Society

1-P1-13 Poster Sessions
Degradation of oligomeric α-Synuclein in brain pericytes is enhanced bycyclosporin A
Shinya Dohgu1, Miki Yokoya1, Fuyuko Takata1, Junichi Matsumoto1, Takuro Iwao1,
Kazunori Sano2, Yasufumi Kataoka1
1

Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2Dept. Physiol. & Pharmacol., Fac.
Pharmaceut. Sci., Fukuoka Univ.

Copyright © The Japanese Pharmacological Society

1-P1-14 Poster Sessions
Brain pericytes increase sodium-dependent glutamate uptake in astrocytes.
Fuyuko Takata1, Kenta Sakai1,2, Takuro Iwao1,2, Junichi Matsumoto2, Yasufumi Kataoka1,
Atsushi Yamauchi2, Shinya Dohgu1
1Department of Pharmaceutical Care and Health Sciences, 2Department of Pharmaceutical Care and Health
Sciences

Copyright © The Japanese Pharmacological Society

1-P1-15 Poster Sessions
Effect of Gpnmb gene on memory deficits in 9 month-old 5xFAD mice
Koichi Kawahara, Yukina Kojima, Natsuki Kumakura, Masaaki Sano, Kota Hosokai,
Takumi Yamada, Takuya Hasegawa, Takehiko Maeda
Dept. Pharmacol., Fac. Pharm. Sci., Niigata Univ. Pharm. Appl. Life. Sci.

Copyright © The Japanese Pharmacological Society

1-P1-16 Poster Sessions
Cholesterol induced calcium oscillation found in astrocytes
Adachi Chihiro, Takafumi Inoue
Dept. Life. Sci. & Med. Biosci. Waseda Univ.

Copyright © The Japanese Pharmacological Society

1-P1-17 Poster Sessions
Zinc-aggravated M1 microglia suppress astrocytic engulfing activity via
P2X7 receptors
Youichirou Higashi1, Takaaki Aratake1,2, Tomoya Hamada1, Takahiro Shimizu1, Shogo Shimizu1,
Suo Zou1, Masaki Yamamoto1, Rina Nakamura1, Toshifumi Akizawa1, Motoaki Saito1
1

Dept. of Pharmacol., Kochi Med. Sch., Kochi Univ., 2JSPS Research Fellow

Copyright © The Japanese Pharmacological Society

1-P1-18 Poster Sessions
Prostaglandin E2 increases the expression of cyclooxygenase-2 protein in
microglia.
Takayuki Nagano, Naohiko Tsuda, Kenichi Fujimura, Yuji Ikezawa, Yuki Higashi, Shinya Kimura
H., Motohiko Takemura
Dept. Pharmacol., Hyogo Coll. Med.

Copyright © The Japanese Pharmacological Society

1-P1-19 Poster Sessions
Study of immunocytochemistry in expression of nucleoside transporter
ENT3 in astrocytes
Koh-ichi Tanaka1,2,3, Wataru Suzuki1, Kento Igarashi1,2, Kazuo Tomita1,2, Nobue Kitanaka3,
Junichi Kitanaka3, Tomoaki Sato2, Motohiko Takemura3
1Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., 2Dept. Applied Pharmacol., Kagoshima
Univ. Grad. Sch. Med. & Dent. Sci., 3Dept. Pharmacol., Hyogo Col. Med.

Copyright © The Japanese Pharmacological Society

1-P1-20

Poster Sessions
2+

An in vivo macroscopic Ca imaging method for analysis of astrocytic Ca
activities in neurodegenerative disease model mice
Yuki Motegi, Masamitsu Iino, Kazunori Kanemaru
Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine

Copyright © The Japanese Pharmacological Society2+1-P1-21 Poster Sessions
Three-dimensional co-culture model using human iPSC
derived brain organoid and microglia-like cells
Mayuko Takata, Kaneyasu Nishimura, Kazuyuki Takata
Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan

Copyright © The Japanese Pharmacological Society

1-P1-22 Poster Sessions
The role of nicotinic acetylcholine receptors on differentiation of iPSCderived macrophages and dopaminergic neurons
Koki Harada1, Takeshi Kato1, Kaneyasu Nishimura1, Masahiro Hirao1, Shun Shimohama2,
Kazuyuki Takata1
1Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan, 2Dept. Neurol., Sapporo Med. Univ. Sch. of Med.,
Sapporo, Japan

Copyright © The Japanese Pharmacological Society

1-P1-23 Poster Sessions
Robust induction of nigro-striatal neurons from human induced pluripotent
stem cells by small compound-based signal controlling
Kaneyasu Nishimura, Naoya Amimoto, Takeshi Kato, Masahiro Hirao, Kazuyuki Takata
Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan

Copyright © The Japanese Pharmacological Society

1-P1-24 Poster Sessions
Toward the generation of thalamic organoids from human induced
pluripotent stem cells
Masatoshi Nishimura1, Nao Morimoto1,2, Fumitaka Osakada1,2,3
1

Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Japan,
Laboratory of Neural Information Processing, Institute for Advanced Research, Nagoya University, Japan,
3
Institute of Nano-Life-Systems, Institutes for Innovation for Future Society, Nagoya University, Japan
2

Copyright © The Japanese Pharmacological Society

1-P1-25 Poster Sessions
Generation of cortical organoids with axial polarity from marmoset
embryonic stem cells
Tomoki Kodera1, Taiki Hara1,2, Nao Morimoto1,3, Fumitaka Osakada1,3
1

Lab. of Cell. Pharmacol., Grad. Sch. of Pharmaseut. Sci., Nagoya Univ., 2Mitsubishi Tanabe Pharma Corp., 3Lab.
of Neural Info. Processing, Inst. for Adv. Res., Nagoya Univ.

Copyright © The Japanese Pharmacological Society

1-P1-26 Poster Sessions
Astrocyte-microglia interaction promotes rotenone-induced dopaminergic
neurotoxicity
Ikuko Miyazaki1, Ryo Kikuoka1, Nami Isooka1, Shinki Murakami1, Chiharu Sogawa2,
Norio Sogawa3, Yoshihisa Kitamura4, Masato Asanuma11Dept. of Medical Neurobiology, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., 2Dept. of Dental
Pharmacology, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., 3Dept. of Dental Pharmacology,
Matsumoto Dental Univ., 4Dept. of Pharmaceutical Care and Health Sciences, Sch. of Pharmacy, Shujitsu Univ.

Copyright © The Japanese Pharmacological Society

1-P1-27 Poster Sessions
Inhibitory effect of neurite outgrowth via glycer-AGEs dependent β-tubulin
abnormal aggregation
Ryuto Nasu1, Furukawa Ayako1, Masayoshi Takeuchi2, Yoshiki Koriyama1
1Grad. Sch. of Pharm. Sci., Suzuka Univ. of Med. Sci., 2Dept. of Adv. Med., Kanazawa Med. Univ.

Copyright © The Japanese Pharmacological Society

1-P1-28 Poster Sessions
Construction of PDGFRβ activation system using optogenetics.
Kimura Yuna, Masatoshi Inden, Hisaka Kurita, Isao Hozumi
Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ.

Copyright © The Japanese Pharmacological Society

1-P1-29 Poster Sessions
High glucose enhances oxidative stress-induced cell death in cultured
neuronal cells
Yuki Ishimaru, Reina Miura, Akinori Tanimura, Tokiyo Yamaguchi, Akiko Yamamuro,Yasuhiro Yoshioka, Sadaaki Maeda
Lab. Pharmacotherap., Fac. Pharmaceut. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society

1-P1-30 Poster Sessions
Effects of the Alzheimer's disease drug rivastigmine on nerve growth factor
via sigma receptor
Matsushima Yukari1, Kazuki Terada2, Kaoru Umehara1, Iwao Sakakibara1
1

Department of Kampo and Natural Product Chemistry, Faculty of Pharmaceutical Sciences,Yokohama Universityof Pharmacy, 2Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka
University

Copyright © The Japanese Pharmacological Society

1-P1-31 Poster Sessions
Effect of forest bioresources for amyloid-β protein and working memory
performance
Iwasa Kensuke1, Kei Maruyama1, Masashi Asai2, Kuniyoshi Shimizu3, Keisuke Yoshikawa1
1

Dept. Pharmacol., Saitama Med University., 2Dept. Faculty of Pharmacy, Yokohama University of Pharmacy.,3
Dept. agro-environmental sciences, Faculty of Agriculture, Graduate School of Kyushu University.

Copyright © The Japanese Pharmacological Society

1-P1-32 Poster Sessions
Neuropathological analysis of Niemann-Pick disease type C using patientderived iPSCs
Ryo Saito1,2, Takashi Miyajima1,3, Chen Wu1,3, Arif Hossain Mohammad1,2, Miyo Munakata1,
Ken Suzuki1, Takeo Iwamoto2, Takumi Era4, Yoshikatsu Eto1,5
1Adv. Clin. Res. Ctr., Southern Tohoku Res. Inst. for Neurosci.,2Core Res. Facilities for Basic Sci., The Jikei Univ.
Sch. of Med., 3Rare disease res. ctr., AnGes Inc., 4Dept. of Cell Modulation, IMEG, Kumamoto Univ., 5The Jikei
Univ. Sch. of Med.

Copyright © The Japanese Pharmacological Society

1-P1-33 Poster Sessions
D-Cysteine regulates chaperone-mediated autophagy and microautophagy
through the generation of hydrogen sulfide.
Ueda Erika1, Takahiro Seki1,2, Ayumu Konno3, Hirokazu Hirai3, Yuki Kurauchi1,2, Hiroshi Katsuki1,21Dept Chemico-Pharmacol Sci, Sch Pharm, Kumamoto Univ, 2Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci,
Kumamoto Univ, 3Dept Neurphysiol Neural Rep, Gunma Univ Grad Sch Med

Copyright © The Japanese Pharmacological Society

1-P1-34 Poster Sessions
Increased glutathione via NOVA1 by administration of an inhibitor of the
microRNA miR-96-5p
Chisato Kinoshita1, Nobuko Matsumura1, Koji Aoyama1, Toshio Nakaki1,21

Dept. Pharmacol., Teikyo Univ. Sch. Med., 2Fac. Pharma-Sci., Teikyo Univ.

Copyright © The Japanese Pharmacological Society

1-P1-35 Poster Sessions
Involvement of cochlear macrophages in the loss of inner hair cell synapses
by noise exposure
Taro Yamaguchi, Yusuke Onaka, Masanori Yoneyama
Lab. Pharmacol. Sci., Sestunan Univ.

Copyright © The Japanese Pharmacological Society

1-P1-36 Poster Sessions
Establishment of a new tri-culture system for elucidating crosstalkmechanisms between brain microvascular endothelial system and central
nervous system in Alzheimer’s disease brains
Tomoya Sasahara1,2, Minako Hoshi1,31Depart. Brain and Neurodegener Dis Res, Institute of Biomedical Research and Innovation, Foundation for
Biomedical Research and Innovation at Kobe, 2Research & Development Division, TAO Health Life Pharma,
3
Depart. Anat and Dev Biol, Graduate School of Medicine, Kyoto Univ.

Copyright © The Japanese Pharmacological Society

1-P1-37 Poster Sessions
Hypercholesterolemia may attenuate cerebral aneurysm
Kazuya Hokamura1,3, Hiroshi Makino2, Takayuki Iwaki1, Ryou Imai2, Tetsuro Kimura2,
Yoshiki Nakajima2, Kazuo Umemura1
1Dept. Pharm., Hamamatsu Univ. Sch. of Med., 2Dept., Anesth., Hamamatsu Univ. Sch. of Med., 3Medical Edu.,
Hamamatsu Univ. Sch. of Med.

Copyright © The Japanese Pharmacological Society

1-P1-38 Poster Sessions
CUD003, a novel synthetic derivative of curcumin, can mitigate middle
cerebral artery occlusion (MCAO)-induced ischemic injury by suppressing
inflammation in rats
Hirokazu Matsuzaki1, Nazuki Sekine1, Hayato Sato1, Azumi Horikoshi2, Takashi Asano1,
Naohiro Iwata3, Xuan Meiyan2, Jun Takayama2, Yuan Bo1, Yasihide Hibino3, Takeshi Sakamoto2,
Mari Okazaki1
1

Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ., 2Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ.,
Immunobiochem., Fac. Pharm. Sci., Josai Univ.

3

Copyright © The Japanese Pharmacological Society

1-P1-39 Poster Sessions
Effect of traditional Japanese medicine, ninjin’yoeito, on cerebral blood flow
in urethane-anesthetized mice
Nobuhiro Watanabe, Kaori Iimura, Harumi Hotta
Dep. Auton. Neurosci., Tokyo Metro. Inst. Gerontol.

Copyright © The Japanese Pharmacological Society

1-P1-40 Poster Sessions
Effects of IL-6 family cytokines on blood-brain barrier function
Sho Hamada, Natsuko Hitora-Imamura, Masabumi Minami
Department of Pharmacology, Hokkaido University

Copyright © The Japanese Pharmacological Society

1-P1-41 Poster Sessions
Transport of docosahexaenoic acid across the blood–brain barrier isdecreased in aged mice
Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yasufumi Kataoka, Shinya Dohgu
Fukuoka University

Copyright © The Japanese Pharmacological Society

1-P1-42 Poster Sessions
Reptiles, sleep, and the claustrum
Norimoto Hiroaki1, Lorenz Fenk1, Hsing-Hsi Li1, Maria Tosches1,2, Tatiana Tatiana1, David Hain1,
Sam Reiter1,3, Riho Kobayashi1,4, Gilles Laurent1
1

Max Planck Institute for Brain Research, 2Columbia University Department of Biological Sciences,
Computational Neuroethology Unit, 4Nagoya City University Graduate School of Pharmaceutical Sciences

3

Copyright © The Japanese Pharmacological Society

1-P1-43 Poster Sessions
Influence of circadian rhythm on the delayed recovery from isoflurane
anesthesia induced by hypnotics in mice
Yoshinori Iba, Atsunobu Sugano, Hiroki Murai, Syunpei Horiguchi, Yuki Amano
Dept. Life Sci., Fac. Sci. and Engineering, Setsunan Univ.

Copyright © The Japanese Pharmacological Society

1-P1-44 Poster Sessions
Real time recording of Period1 gene in the central and peripheral tissues ofthe freely moving streptozotocin-treated diabetic mouse.
Nagasawa Koki1, Yuki Ishii1, Ryosuke Sato1, Mizuki Nakaya1, Juri Hayashi1, Yukina Yoshida1,
Masayori Ishikawa2, Michitaka Ozaki3, Kazuko Hamada1, Toshiyuki Hamada1
1

IUHW.Dept.Phamaceut, 2Hokkaido.Uni.Fac.Health Sci, 3Hokkaido.Uni.Fac.Health Sci

Copyright © The Japanese Pharmacological Society

1-P1-45 Poster Sessions
The analysis of Period1 gene expression in freely moving mouse using
micro PMT system.
Yuki Ishii1, Juri Hayashi1, Mizuki Nakaya1, Ryosuke Sato1, Yukina Yoshida1, Kouki Nagasawa1,
Masayori Ishikawa2, Michitaka Ozaki3, Kazuko Hamada1, Toshiyuki Hamada1
1

IUHW.Dept.Phamaceut, 2Hokkaido,Uni.Fac.Heaith Sci., 3Hokkaido,Uni.Fac.Heaith Sci.

Copyright © The Japanese Pharmacological Society

1-P2-01 Poster Sessions
Moxifloxacin exacerbate aortic aneurysm and aortic dissection by increasing
osteopontin protein expressions
Koshun Inada1, Mitsuhisa Koga2, Atsushi Yamauchi3
1

Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 2Dept. Drug Design and Drug
Delivery., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 3Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci.,
Fukuoka Univ.,

Copyright © The Japanese Pharmacological Society

1-P2-02 Poster Sessions
Role of tissue type plasminogen activator in a murine model of type IIa
human familial hypercholesterolemia
Arakawa Tomohiro1, Takayuki Iwaki1, Masamitsu Takaba2, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2Third Div., Dept. Intern. Med., Hamamatsu Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society

1-P2-03 Poster Sessions
Effect of pretreatment with diltiazem on mast cell degranulation byadrenaline treatment in anaphylactic rats.
Sawano Mayu, Wakana Takatsu, Seiichiro Kano
Fac.Pharm.Sci.,Hokkaido Univ of Sci.

Copyright © The Japanese Pharmacological Society

1-P2-04 Poster Sessions
Development and functional analysis of novel PCSK9/LDLR interaction
inhibitors for hypercholesterolemia treatment
Takumi Yokoyama1, Takehiro Ando1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1

Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. Life
Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi
Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO

Copyright © The Japanese Pharmacological Society

1-P2-05 Poster Sessions
Effect of uridine triphosphate and uridine diphosphate on vascular functionin the carotid arteries of spontaneously hypertensive rats
Katome Tomoki, Takayuki Matsumoto, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi,
Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.

Copyright © The Japanese Pharmacological Society

1-P2-06 Poster Sessions
Activation of transient receptor potential vanilloid 4 channels dilates the rat
retinal arterioles via the production and release of nitric oxide and the2++activation of large-conductance Ca -activated K channels in vivo
1,2

1

1,2

1

Asami Mori , Kazuki Takeda , Kenji Sakamoto , Tsutomu Nakahara
1

Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2Lab. Med. Pharmacol., Fac Pharma-Sci. Teikyo Univ.

Copyright © The Japanese Pharmacological Society

1-P2-07 Poster Sessions
Endothelial Function in Coronary Arteries from Pneumonia-Infected Pigs
Masashi Tawa, Katsuya Nakano, Qiang He, Takayoshi Masuoka, Takaharu Ishibashi
Dept. Pharmacol., Kanazawa Med. Univ.

Copyright © The Japanese Pharmacological Society

1-P2-08 Poster Sessions
Benzodiazepines and non-benzodiazepine drugs have direct vasorelaxant
effects
Satomi Kagota1, Kana Morikawa1, Hirotake Ishida2, Junko Chimoto2, Kana Fumoto1,
Shizuo Yamada,2, Kazumasa Shinozuka1
1

Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ, 2Centr. for Pharm-Food Res, Univ. of
Shizuoka

Copyright © The Japanese Pharmacological Society

1-P2-09 Poster Sessions
Apelin attenuated advanced glycation end products-induced cell death inmouse endothelial cell line bEnd.3.
Yasuhiro Yoshioka, Haruku Yamamoto, Shigenori Yoshizawa, Akiko Yamamuro, Yuki Ishimaru,
Sadaaki Maeda
Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., Osaka 573-0101, Japan

Copyright © The Japanese Pharmacological Society

1-P2-10 Poster Sessions
Effects of gas phase extract of cigarette smoke generated from heated
tobacco and burned cigarette on human vascular endothelial cells
Takahiro Horinouchi1, Yuichi Mazaki1, Soichi Miwa2
1

Dept. Cell. Pharmacol., Grad. Sch. Med., Hokkaido Univ. Sapporo 060-8638, Japan., 2Toyooka Gen. Hosp., Hyogo
668-8501, Japan.

Copyright © The Japanese Pharmacological Society

1-P2-11 Poster Sessions
Microvascular endothelial model that can predict the inflammatory
responses in human microvessels with high reproducibility: Culture modelof an hCMEC/D3 cell line fabricated in a collagen vitrigel membrane chamber
Miaki Uzu, Toshiaki Takezawa
Vitrigel Project, Institute of Agrobiological Sciences, NARO

Copyright © The Japanese Pharmacological Society

1-P2-12 Poster Sessions
Retinoic acid promotes barrier functions in human iPS cell-derived intestinal
epithelium
Shigeru Yamada1,2, Yasunari Kanda1
1Div. Pharmacol, NIHS, 2PEIJ

Copyright © The Japanese Pharmacological Society

1-P2-13 Poster Sessions
Maintenance of intestinal homeostasis by NAD metabolism
Yaku Keisuke, Takashi Nakagawa
Dept. of Mol. and Med. Pharmacol., Fac. of Med., Univ. of Toyama

Copyright © The Japanese Pharmacological Society

1-P2-14 Poster Sessions
Oral administration of 5,6-DiHETE attenuates DSS-induced colitis in mice
Shinya Takenouchi, Daiki Imai, Koji Kobayashi, Tatsuro Nakamura, Nanae Nagata,
Takahisa Murata
Dept. Animal Radiology, Univ. Tokyo

Copyright © The Japanese Pharmacological Society

1-P2-15 Poster Sessions
Role of TRPM2 expressed in macrophages in TNBS-induced colonic fibrosis
in mice
Nakamoto Tomohiro1, Kenjiro Matsumoto1, Hiroyuki Yasuda1, Yasuo Mori2, Shinichi Kato1
1

Dept. of Pharmacol. and Exp. Therap., Kyoto Pharmaceut. Univ., 2Dept. of Synthetic Chem. and Biological Chem.,
Grad. Sch. of Eng., Kyoto Univ.

Copyright © The Japanese Pharmacological Society

1-P2-16 Poster Sessions
Assessment of the effects of docosahexaenoic acid (DHA) andeicosapentaenoic acid (EPA) on the contractile responses of guinea pig
lower gastrointestinal (LGI) tracts
Keisuke Obara, Keyue Xu, Guanghan Ou, Rikako Inaba, Mirai Kawakita, Ayana Kawaguchi,
Rena Kudo, Akari Kurata, Kento Yoshioka, Fumiko Yamaki, Yoshio Tanaka
Dept. Chem. Pharmacol., Facul. Pharmaceut. Sci., Toho Univ.

Copyright © The Japanese Pharmacological Society

1-P2-17 Poster Sessions
Daikenchuto attenuates visceral pain and suppresses eosinophil infiltration
in inflammatory bowel disease in murine models
Kogure Yoko1, Hirosato Kanda1,2,3, Shenglan Wang1,4, Satoshi Yamamoto1, Koichi Noguchi3,
Yi Dai1,2,3
1

Dept. Pharm. Sch. Pharm. Hyogo Univ. Health Sci., 2Tral Med. Res. Ctr, Chn Med. CI at Hyogo Col. Med., 3Dept.
Anat. Neurosci., Hyogo Col. Med., 4Sch. Acup-Mox
Tuina, Beijing Univ. Chn Med.

Copyright © The Japanese Pharmacological Society

1-P2-18 Poster Sessions
Lacking dietary fiber enhances sensitivity to inflammatory stimuli, that
results in intestinal hyper-permeability.
Haruki Usuda, Syoma Kanda, Takayuki Okamoto, Koichiro Wada
Dept. Pharmaco., Fac. Med., Shimane Univ.

Copyright © The Japanese Pharmacological Society

1-P2-19 Poster Sessions
Effect of oyster extract on gastrointestinal and myeloid toxicity of 5-FU inrats
Noriyuki Yamazaki1, Suzuki Kohtaro1, Keita Saitoh1, Kohei Araki1, Yuki Ishida1, Hiroki Morikawa1,
Takuma Nakajima1, Tohru Nonomura1, Makoto Konno1, Tatsuya Ishida2, Hiroyuki Matsui2,
Yoshikazu Matsuda2
1

New Drug Research Center, Inc., 2Central Research Institute, Japan Clinic Co, Ltd

Copyright © The Japanese Pharmacological Society

1-P2-20 Poster Sessions
Effect of oyster extract on toxicity and pharmacological action of steroids inrats
Makoto Konno1, Hiroki Morikawa1, Masaharu Igarashi1, Masumi Kikuta1, Hitoshi Goto1,
Noriyuki Yamazaki1, Katsura Matsuda2, Tatsuya Ishida2, Hiroyuki Matsui2, Yoshikazu Matsuda2
1

New Drug Research Center, Inc., 2Central Research Institute, Japan Clinic Co, Ltd.

Copyright © The Japanese Pharmacological Society

1-P2-21 Poster Sessions
Prenylated quinolinecarboxylic acid compound-18 prevents sensory nerve
fiber outgrowth through inhibition of the interleukin-31 pathway
Masato Ogura, Kumiko Endo, Toshiyuki Suzuki, Yoshimi Homma
Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan

Copyright © The Japanese Pharmacological Society

1-P2-22 Poster Sessions
Loss of skeletal muscle mass influences immune homeostasis andaccelerates the disease progression of lupus nephritis
Shuang Liu1, Takeshi Kiyoi2, Masaki Mogi1
1

Dept. Pharmacol., Grad. Sch. Med., Ehime Univ., 2ADRES, Ehime Univ.

Copyright © The Japanese Pharmacological Society

1-P2-23 Poster Sessions
Activated coagulation factors induce histamine release of human skin mast
cells and peripheral basophils through activation of complement system
Yuhki Yanase1, Yoshimi Matsuo2, Tomoko Kawaguchi2, Kaori Ishii2, Koichiro Ozawa1,
Michihiro Hide2
1

Dept. of Parmacotherapy, Hiroshima University, 2Dept. of Dermatology, Hiroshima University

Copyright © The Japanese Pharmacological Society

1-P2-24 Poster Sessions
Anti-inflammatory mechanism of Nrf2-ARE activator in chronic contact
hypersensitivity model mice
Mana Nonoguchi1, Yuki Takada-Takatori1, Risa Imai1, Namiko Shouno1, Yasuhiko Izumi2,3,
Akinori Akaike2,4, Toshiaki Kume2,5, Katsuharu Tsuchida1, Kei-ichi Ozaki1
1Fac. Pharmaceut. Sci., Doshisha Women's Coll., 2Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ.,
3
Kobe Pharmaceut. Univ., 4Wakayama Med. Univ., 5Dept. Appl. Pharmacol., Grad. Sch. Medicinal and Pharmaceut.
Sci., Univ.Toyama

Copyright © The Japanese Pharmacological Society

1-P2-25 Poster Sessions
A Discussion on the Mechanism of Actions of a gold compound, Auranofin
Masamichi Yamashita
Dept. Biosci. Daily Life, Coll. Biores. Sci., Nihon Univ.

Copyright © The Japanese Pharmacological Society

1-P2-26 Poster Sessions
The role of sphingosine 1-phosphate receptor 2 on interleukin (IL)-4/IL-13induced STAT6 phosphorylation in phorbol 12-myristate 13-acetatestimulated THP-1 cells
Yasuo Okamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Shinya Yamamoto, Kazuhito Tsuboi
Kawasaki Med. Sch.

Copyright © The Japanese Pharmacological Society

1-P2-27 Poster Sessions
Upregulation of P2X7 receptor signaling by interleukin-33 in mouse bonemarrow-derived mast cells
Kazuki Yoshida, Yuu Ishida, Masaaki Ito, Isao Matsuoka
Lab. Pharmacol., Fact. Pharm, Takasaki Univ. Health and Welfare

Copyright © The Japanese Pharmacological Society

1-P2-28 Poster Sessions
P2Y receptor activation and PI3K(δ) enhance human-derived mast cell
degranulation
Haruhisa Nishi1, François Niyonsaba2,31

Dept. Pharmacol., Sch. Med., Jikei Univ. Sch. Med., 2Atopy Res. Cent., Grad. Sch. Med., Juntendo Univ., 3Fac.
International Liberal Arts

Copyright © The Japanese Pharmacological Society

1-P2-29 Poster Sessions
Development and functional analysis of novel IL-6R/IL-6 interaction
inhibitors for autoimmune disease treatment
Yukio Takamori1, Takehiro Ando1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1

Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. Life
Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi
Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO

Copyright © The Japanese Pharmacological Society

1-P2-30 Poster Sessions
Development and functional analysis of novel TNF-alpha/TNFR interaction
inhibitors for autoimmune disease treatment
Keita Tsukamoto1, Takehiro Ando1, Yukio Takamori1, Daisuke Fuji2, Mizuki Yamamoto3,
Takashi Kawakami4,5
1

Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. Life
Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi
Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ,5JST, PRESTO

Copyright © The Japanese Pharmacological Society

1-P2-31 Poster Sessions
Transrepression-selective liver X receptor (LXR) ligands regulate
inflammasome activation
Sayaka Takahashi1, Kaori Umeda-Endo2, Makoto Makishima2, Hashimoto Yuichi3,
Toshiaki Ishizuka1, Minoru Ishikawa4
1

National Defense Medical College, 2Nihon University School of Medicin, 3Institute for Quantitative Biosciences,
The University of Tokyo, 4Graduate School of Life Sciences, Tohoku University

Copyright © The Japanese Pharmacological Society

1-P2-32 Poster Sessions
Risk management of L-Asparaginase-induced allergy: focusing on theinfluence of cyclophosphamide
Ai Nogami-Hara1, Yuta Hori1, Chie Mitsuhata1, Koji Kajiyama1, Kentaro Susuki1, Akira Shimada2,
Mitsunobu Mio1
1

Lab. Pharmacol., Sch. Pharm., Shujitsu Univ., 2Dept. Pediatr. Hematol. Oncol., Okayama Univ.

Copyright © The Japanese Pharmacological Society

1-P2-33 Poster Sessions
Pharmacological evaluation in atopic dermatitis models induced by mite
antigen in mice
Nagayama Manami, Ayaka Yamaguchi, Ryota Yagi, Kumiko Kitta, Atsuko Ichikawa, Junichi Fuchikami, Yasuki Akie
CMIC Pharma Science Co., Ltd.

Copyright © The Japanese Pharmacological Society

1-P2-34 Poster Sessions
FK506-binding protein contributes to tacrolimus distribution in red bloodcells
Naoki Yoshikawa1, Ayako Matsuo2, Tsubasa Yokota1, Tomomi Iwakiri1, Ryuji Ikeda1
1

Dept. Pharm., Univ. Miyazaki Hosp., 2Dept. Respiratory Med., Univ. Miyazaki Hosp.

Copyright © The Japanese Pharmacological Society

1-P2-35 Poster Sessions
Exploring the mechanism of action of maoto, a traditional Japanese
medicine, on acute systemic inflammation induced by polyI:C administration
Keisuke Ogura, Ayumi Kadota, Akinori Nishi, Akiko Nakayama, Hitomi Kannno, Yoshiki Ikeda
Tsumura Kampo Research Laboratories, Tsumura and Co.

Copyright © The Japanese Pharmacological Society

1-P2-36 Poster Sessions
Investigation of genetic variants in SARS-CoV-2-interacting molecules of
ACE2, TMPRSS2 and TLR3/7/8 across populations
Lee Ji-Won1, In-Hee Lee2, Sek Won Kong2,3, Tadahiro Iimura1
1Dept. Pharmacol., Grad. Sch., Hokkaido Univ., 2Boston Children’s Hospital, 3Harvard Med. Sch.

Copyright © The Japanese Pharmacological Society

1-P2-37 Poster Sessions
Development and functional analysis of novel HER3/HRG interaction
inhibitors for cancer treatment
Takehiro Ando1, Takumi Yokoyama1, Rina Iwamoto1, Daisuke Fuji2, Mizuki Yamamoto3,
Takashi Kawakami4,5
1

Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. Life
Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi
Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO

Copyright © The Japanese Pharmacological Society

1-P2-38 Poster Sessions
Development and functional analysis of novel VEGFR2/VEGF interaction
inhibitors for angiogenesis inhibition
Horiuchi Daisuke1, Takehiro Ando1, Fuji Daisuke2, Mizuki Yamamoto3, Takashi Kawakami4,5
1

Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. Life
Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi
Univ., 4Fac. Life Environ. Sci., Gred. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO

Copyright © The Japanese Pharmacological Society

1-P2-39 Poster Sessions
Development and functional analysis of novel PD-L1/PD-1 interaction
inhibitors for cancer immunotherapy
Iwamoto Rina1, Takehiro Ando1, Daisuke Horiuchi1, Daisuke Fuji2, Mizuki Yamamoto3,
Takashi Kawakami4,5
1

Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. Life
Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi
Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO

Copyright © The Japanese Pharmacological Society

1-P2-40 Poster Sessions
Cytotoxic effects of mushroom extracts banked in FMRC
Kenji Takahashi1,2, Atsushi Ishihara2, Toshio Ohta1,2
1

Tottori Univ. Joint Dep Vet Med. Vet Pharmacol.,2Tottori Univ. Fac. Agr. FMRC

Copyright © The Japanese Pharmacological Society

1-P2-41 Poster Sessions
Molecular and Functional Analysis of Choline Transporters and Antitumor
Effects of Choline Transporter-Like Protein 1 Inhibitors in Human
Hepatocellular Carcinoma Cells
Masato Inazu1,2, Akane Hase1, Kaho Hirai1, Saiichiro Watanabe1, Kaoru Shibata1,
Tsuyoshi Yamanaka2
1

Inst. Med. Sci., Tokyo Med. Univ., 2Dept. Mol. Preventive Med., Tokyo Med. Univ.

Copyright © The Japanese Pharmacological Society

1-P2-42 Poster Sessions
Dysfunction of DUSP22 induces synthetic lethality in poly(ADP-ribose)
glycohydrolase (PARG) knocked down lung cancer cell lines.
Yuka Sasaki1,2, Hiroaki Fujimori2, Takae Onodera1,2, Tadashige Nozaki1,3, Fumiaki Koizumi1,4,
Mitsuko Masutani1,21

Dept. Molecular and Genomic Biomedicine, Grad. Sch. Biomed. Sci. & CBMM, Nagasaki Univ., 2Natl. Cancer Ctr.
Res. Inst., 3Dept. Pharmacol. Osaka Dent. Univ.., 4Div. Clin. Res. Support, Komagome Hosp.

Copyright © The Japanese Pharmacological Society

1-P2-43 Poster Sessions
Study of Anti-proliferative Effects of Chaga Mushroom and Panax
Notoginseng-containing Traditional Chinese Medical Supplement, Shibe-ria
on Dog Bladder Cancer Stem Cells
Yuta Shinohara1,2, Yomogi Sato1, Mohamed Elbadawy1,3, Megumi Yamanaka1, Yuta Goto1,
Kimika Hayashi1, Amira Abugomaa1, Tatsuya Usui1, Kazuaki Sasaki1
1Dept. Vet Med., Fac. agr., Tokyo Univ of Agr and Tech.,2Division. Pet Health and Food., Iskara Industry CO.,LTD., 3Dept. Pharm., Fac. Vet med., Benha Univ.

Copyright © The Japanese Pharmacological Society

1-P2-44 Poster Sessions
Development of an anti-cancer drug sensitivity test using a urine samplederived organoid culture for dog bladder cancer
Mori Masahiro, Yomogi Sato, Mohamed Elbadawy, Tatsuya Usui, Kazuaki Sasaki
Lab. of Veterinary Pharmacology, Dept of Veterinary Medicine, Fac. of Agriculture, Tokyo Univ. of Agriculture andTechnology

Copyright © The Japanese Pharmacological Society

1-P2-45 Poster Sessions
Establishment of a culture method of the human bladder cancer organoidusing the urine sample
Kodai Fujisaka1, Mohamed Elbadawy1,2, Yomogi Sato1, Haru Yamamoto1, Hiroaki Matsumoto3,
Hideyasu Matsuyama3, Masahiro Kaneda4, Tatsuya Usui1, Kazuaki Sasaki1
1

Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo
University of Agriculture and Technology, 2Department of Pharmacology, Faculty of Veterinary Medicine, Benha
University, 3Department of Urology, Graduate School of Medicine, Yamaguchi University,4Laboratory of Veterinary
Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture andTechnology

Copyright © The Japanese Pharmacological Society

1-P2-46 Poster Sessions
Establishment of a culture method of the dog lung cancer organoid
Sato Yomogi1, Mohamed Elbadawy1,2, Daigo Azakami3, Masahiro Kaneda4, Tatsuya Usui1,
Kazuaki Sasaki1
1

Lab. Veterinary Pharmacol., Dept. Veterinary Medic., Fac. Agri., Tokyo University of Agri. and Tech.,2Benha Univ,
Fac. Veterinary Med., Dept. Pharmacol., 3Lab. Veterinary Clin. Oncology, Dept. Veterinary Medic., Fac. Agri.,Tokyo University of Agri. and Tech., 4Lab. Veterinary Anatomy., Dept. Veterinary Medic., Fac. Agri., Tokyo
University of Agri. and Tech.

Copyright © The Japanese Pharmacological Society