2-Y-E1-1 YIA
Recombinant human α2δ-1 purification for structural analysis of mirogabalinbinding mode
1,2

3

4

4,5

6

Daisuke Kozai , Nobutaka Numoto , Kouki Nishikawa , Akiko Kamegawa , Hiroyuki Hanzawa ,
7
6
7
4,5
Kousei Shimada , Mizuki Takahashi , Yutaka Kitano , Yoshinori Fujiyoshi
1

CeSPI, Nagoya Univ., 2JBIC, 3Med. Res. Inst., Tokyo Med. and Dent. Univ., 4CeSPIA Inc., 5Adv. Res. Inst., Tokyo
Med. and Dent. Univ., 6Daiichi-Sankyo RD Novare Co., Ltd., 7Daiichi-Sankyo Co., Ltd.

Copyright © The Japanese Pharmacological Society2-Y-E1-2 YIA
V1a Vasopressin Receptor Deficient Mice as a Model for Accelerated Aging
Casmad Fujianti, Morio Azuma, Sajjaviriya Chortip, Hiroyoshi Tsuchiya, Taka-aki Koshimizu
Juchi Med. Univ. Mol. Pharmacol.

Copyright © The Japanese Pharmacological Society2-Y-E1-3 YIA
1,2-Naphthoquinone functions as an activator of the EGF receptor via
covalent modification of a specific lysine residue
Kengo Nakahara1, Tomoki Tsuchida1, Yumi Abiko2, Yoshito Kumagai2, Takashi Uehara1
1

Department of Medical pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences,
Okayama University, 2Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba

Copyright © The Japanese Pharmacological Society2-Y-E1-4 YIA
EGFP-tagged Syntaxin 17 localized on autophagosome is accumulated by
Doxorubicin
Guanjie Li1, Delan Lin1, Noriko Toda1,2, Masaki Saito1, Masanori Yamauchi2, Kazuhiko Yanai1,3,
Takeya Sato1
1

Dept. Mol. Pharmacol., Tohoku Univ., Grad. Sch. Med, 2Dept. Anes & Perio Med., Tohoku Univ., Grad. Sch. Med,
3
Dept. Pharmacol., Tohoku Univ., Grad. Sch. Med

Copyright © The Japanese Pharmacological Society2-Y-E2-1 YIATranscription factor ATF4 maintains pancreatic β-cell identity during ER
stressKeisuke Kitakaze1,2, Miho Oyadomari1, Jun Zhang1, Yoshimasa Hamada1, Yasuhiro Takenouchi2,
Kazuhito Tsuboi2, Yoshio Fujitani3, Yasuo Okamoto2, Seiichi Oyadomari1
1Div. of Mol. Biol., Inst. for Genome Res., Inst. of Adv. Med. Sci., Tokushima Univ.,2Dept. of Pharmacol., Kawasaki
Med. Sch., 3Lab. of Dev. Biol. and Metab. Inst. for Mol. and Cell. Regul., Gunma Univ.

Copyright © The Japanese Pharmacological Society2-Y-E2-2 YIA
Role of alpha 1 antitrypsin-induced ER stress in placental trophoblast cells
Kanoko Yoshida1, Kazuya Kusama1, Kiyoko Kato2, Gen Ishikawa3, Mikihiro Yoshie1,
Kazuhiro Tamura1
1Dept. Pharmacol., Tokyo Univ. Pharm. & Life Sci., 2Dept. Obstet. & Gynecol., Kyushu Univ., 3Dept. Obstet. &Gynecol., Nippon Med. Sch.

Copyright © The Japanese Pharmacological Society2-Y-E2-3 YIA
Globin Digest Exerts Anti-Obesity Effects through UCP1 Upregulation in
Zebrafish and Mouse Obesity Models
Zang Liqing1, Yasuhito Shimada2, Hiroko Nakayama1, Izumi Matsuoka1, Youngil Kim3, DjongChi Chu3, Lekh Raj Juneja3, Rika Tsuruta4, Yuka Sasakawa4, Junya Kuroyanagi5,
Norihiro Nishimura1
1

Grad. Sch. of Regional Innovation Studies, Mie Univ., 2Dept. Integr. Pharmacol., 3Rohto Pharmaceut. Co., Ltd.,MG Pharma Inc., 5UMOU Sci. Lab

4

Copyright © The Japanese Pharmacological Society2-Y-E2-4 YIA
Comprehensive cardiotoxicity assessment of hydroxychloroquine using
human iPSC-derived cardiomyocytes
Yanagida Shota1,2, Ayano Satsuka1, Sayo Hayashi1, Atsushi Ono2, Yasunari Kanda1
1Div. Pharmacol, NIHS, 2Div. Pharmaceut. Sci, Grad Sch Med., Dent. and Pharmacet. Sci, Okayama Univ.

Copyright © The Japanese Pharmacological Society2-Y-E3-1 YIA
Chemerin/CMKLR1 in the brain of spontaneously hypertensive rats mediates
systemic hypertension
Atsunori Yamamoto1, Naoko Yamaguchi2, Shoshiro Okada2, Kosuke Otani1, Muneyoshi Okada1,
Hideyuki Yamawaki1
1

Lab. Vet Pharmacol., Sch., Vet. Med., Kitasato Univ.,2Dept. Pharmacol., Sch., Med., Aichi Med. Univ.

Copyright © The Japanese Pharmacological Society2-Y-E3-2 YIA
The alteration of molecular properties in plasma extracellular vesicles fromspontaneously hypertensive rats
Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University

Copyright © The Japanese Pharmacological Society2-Y-E3-3 YIA
Evaluation of the pathological symptoms in retinal vascular disease withneovascular glaucoma
Anri Nishinaka, Miruto Tanaka, Koki Nitta, Shinsuke Nakamura, Masamitsu Shimazawa,
Hideaki Hara
Gifu Pharmaceut . Univ.

Copyright © The Japanese Pharmacological Society2-Y-E3-4 YIA
The role of ANKFY1 in endothelial cells for retinal angiogenesis
Miruto Tanaka1, Shinsuke Nakamura1, Masashi Maekawa2,3, Shigeki Higashiyama2,3,
Hideaki Hara1
1

Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 2Division of
Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University,3Department of Biochemistry andMolecular Genetics, Ehime University Graduate School of Medicine

Copyright © The Japanese Pharmacological Society2-Y-F1-1 YIA
Inhibitory effect of panaxytriol on the lipopolysaccharide-induced microglial
activation
Genki Hiramatsu1, Kosuke Matsuda1, Daisuke Uta1, Kenichi Mihara2, Ysuhunobu Andoh4,
Toshiaki Kume1
1

Dept. Appl Pharmcol. Toyama Univ., 2Dept. Appl Pharmcol. Toyama Univ., 3KIM's Korean Ginseng Co. Ltd., 4Dept.
Pharmacol & Pathophysiol. Kinjo Gakuin Univ.

Copyright © The Japanese Pharmacological Society2-Y-F1-2 YIA
Real-time imaging unveils mechanisms underlying synaptic engulfment by
microglia
Megumi Andoh1, Yuji Ikegaya1,2,3, Ryuta Koyama1,4
1Lab. of Chem. Pharmacol., Grad. Sch. of Pharmaceut. Sci., The Univ. of Tokyo, 2Inst. for AI and Beyond, 3Center
for Information and Neural Networks, 4Japan Sci. and Tech. Agency, PRESTO

Copyright © The Japanese Pharmacological Society2-Y-F1-3 YIA
Identification of scavenger inducing factor for the accelerated removal of
inflammatogenic DAMPs
Otani Kento1,2, Jun Tsuyama1, Koji Hase2, Takashi Shichita11Stroke Renaissance Project, Tokyo Met. Inst. of Med. Sci., 2Dept. Biochem., Grad. Sch. of Pharmaceutical Sci.,
Keio Univ.

Copyright © The Japanese Pharmacological Society2-Y-F1-4 YIA
A subpopulation of microglia emerged in a recovery phase of neuropathic
pain
Kohno Keita, Makoto Tsuda
Dept. Mol. and Syst. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ.

Copyright © The Japanese Pharmacological Society2-Y-F2-1 YIA
Intrathecal injection of sulfatides induced mechanical allodynia via glial cells
activation and nitric oxide production
Motoki Morita1,2, Shun Watanabe1,2, Misa Oyama1,2, Takashi Iwai1,2, Mitsuo Tanabe1,2
1Lab. Pharm., Sch. Pharm., Kitasato Univ., 2Medical Research Lab.,Sch. Pharm.,Kitasato Univ.

Copyright © The Japanese Pharmacological Society2-Y-F2-2 YIATreatment with anti-interleukin-6 receptor antibody improves mechanicalhypersensitivity and cognitive dysfunction in mice with neuropathic pain
Kodai Moriwaki1, Kazue Nakashima2, Toshiki Yoshii1, Yoki Nakamura2, Norimitsu Morioka2
1

Dept. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., 2Sch. Pharmaceu. Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society2-Y-F2-3 YIA
Comprehensive analysis of epigenetic modification under a persistent
postoperative pain-like state
Tanaka Kenichi1,3, Yoshiyuki Yamabe1,3, Michiko Narita2,3, Hideyuki Takesima4,
Yusuke Hamada1,3, Daisuke Sato1,3, Yosuke Katsuda1,5, Masako Iseki5, Takahiro Ochiya2,
Naoko Kuzumaki1, Toshikazu Ushijima4, Minoru Narita1,3,5
1

Dept. Pharmacol., Hoshi Univ., Tokyo, Japan, 2Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan,
Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan,4Div. Epigenomics, Natl. Cancer Ctr. Res. Inst.,
Tokyo, Japan, 5Dept. Anesthesiol., Pain Med., Juntendo Univ., Tokyo, Japan3

Copyright © The Japanese Pharmacological Society2-Y-F2-4 YIA
Inhibitory effects of anti-high mobility group box-1 neutralizing antibody on
nociceptive hypersensitivity in Parkinson’s disease
Fumiaki Sato1, Yoki Nakamura2, Simeng Ma2, Takahiro Kochi2,3, Kazue Hisaoka-Nakashima2,
Wang Dengli4, Keyue Liu4, Hidenori Wake4, Masahiro Nishibori4, Norimitsu Morioka2
1Sch. Pharmaceu. Sci., Hiroshima Univ., 2Dept. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ.,
3
Dept. Dent. Anesth., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., 4Dept. Pharmacol., Grad. Sch. Med.,
Dentistry & Pharmaceu. Sci., Okayama Univ.

Copyright © The Japanese Pharmacological Society2-Y-F3-1 YIA
An essential role of the median raphe serotonin neurons projecting to theinterpeduncular nucleus in reward processing.
Kawai Hiroyuki1, Yuma Nagai1, Masashi Koda1, Naoya Nishitani2, Kazuki Nagayasu1,
Hisashi Shirakawa1, Shuji Kaneko1
1

Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 2Lab. Mol. Pharmacol., Inst. Med.,
Pharmaceut., Health Sci., Kanazawa Univ.

Copyright © The Japanese Pharmacological Society2-Y-F3-2 YIADistinct role of heterogeneously expressed receptors on D2-receptorcontaining medium spiny neurons in the development of behavioral
sensitization induced by abused drugs
Kensuke Yamashita1, Kotaro Oikawa1, Yusuke Hamada1,2, Daisuke Sato1, Michiko Narita2,3,
Naoko Kuzumaki1, Tomohisa Mori1, Minoru Narita1,21

Dept. Pharmacol., Hoshi Univ., Tokyo, Japan, 2Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan,
Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan3

Copyright © The Japanese Pharmacological Society2-Y-F3-3 YIA
Piccolo knockdown in the nucleus accumbens suppressed
methamphetamine-induced alterations
Yuka Kusui1, Kyosuke Uno1,2, Shin-ichi Muramatsu3,4, Atsumi Nitta1
1

Dept. Pharm Therap and NeuroPharm, 2Dept. Funct Molphology, 3Univ. Jichiika, 4Univ. Tokyo Ctr. Therap gene

Copyright © The Japanese Pharmacological Society2-Y-F3-4 YIA
Oxytocin reverses 3,4-Methylenedioxypyrovalerone-induced impairment ofhippocampal synaptic plasticity in mice
Takahshi Junpei1, Daisuke Yamada1, Kosho Makino2, Ryo Fujikawa1, Toshinori Yoshioka1,
Eri Koga1, Hideyo Takahashi2, Akiyoshi Saitoh1
1

Lab Pharmacol., Fac Pham Sci, Tokyo Univ of Science, 2Lab Med Chem., Fac Pham Sci, Tokyo Univ of Science

Copyright © The Japanese Pharmacological Society2-Y-G1-1 YIA
Chemogenetic inhibition of histaminergic neurons significantly decreased
wakefulness during the dark periods in mice.
Hiroshi Kuroyanagi, Masato Tanaka, Fumito Naganuma, Tadaho Nakamura, Nobuyuki Okamura
Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University

Copyright © The Japanese Pharmacological Society2-Y-G1-2 YIA
Acute effect of ramelteon treatment on central and peripheral activity of rats
during wakefulness and sleep
Airi Yoshimoto1,2, Kotaro Yamashiro2, Takeshi Suzuki1, Yuji Ikegaya2, Nobuyoshi Matsumoto2
1

Keio Univ. Fac. Pharm., 2Grad. Sch. Pharmaceut. Sci., Univ. Tokyo

Copyright © The Japanese Pharmacological Society2-Y-G1-3 YIA
The role of the formin protein Fhod3 in morphogenesis of dendritic spines in
the mouse cerebral cortex
Hikmawan Wahyu Sulistomo1,2, Takayuki Nemoto1,3, Yohko Kage1, Hajime Fujii4, Haruhiko Bito4,
Ryu Takeya1
1

Dept. of Pharmacol., Fac. of Med., Univ. of Miyazaki, 2Dept. of Pharmacol., Fac. of Med., Univ. of Brawijaya,
3
Dept. of Pharmacol., Fac. of Med., Fukuoka Univ., 4Dept of Neurochem., Grad. Sch. of Med., The Univ. of Tokyo

Copyright © The Japanese Pharmacological Society2-Y-G1-4 YIA
Proliferative effect of tri-deoxyribonucleotides on mouse neural stem cells
Takahiro Ishimoto1, Naoto Matsumura1, Yusuke Masuo1, Keisuke Kiriyama2, Keita Sutoh2,
Yukio Kato1
1Fac. Pharm., Kanazawa Univ., 2FORDAYS Co., Ltd.

Copyright © The Japanese Pharmacological Society2-Y-G2-1 YIA
Muscle specific aging signature of PDGFRα-positive stromal cells underlies
the development of age-related sarcopenia
Kurosawa Tamaki1,2, Noriyuki Kaji3, Madoka Uezumi2, Heying Zhou2, Keitaro Minato2,
Akiyoshi Uezumi2, Masatoshi Hori1
1

Lab. of Veterinary Pharmacol., Dept. of Veterinary Med. Sci., Grad. Sch. of Agr. and Life Sci., Tokyo Univ.,2Muscle
Aging and Regenerative Med., Tokyo Metropolitan Inst., of Gerontol., 3Lab. of Veterinary Pharmacol., Sch. of
Veterinary Med., Azabu Univ.

Copyright © The Japanese Pharmacological Society2-Y-G2-2 YIATreatment with resveratrol attenuates aging-related loss of muscle mass andfunction in mice.
Ryusuke Hosoda, Atsushi Kuno, Seidai Asakura, Naotoshi Iwahara, Iyori Nojima,
Risa Kunimoto, Yoshiyuki Horio
Dept. Pharmacol., Sapporo Med. Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society2-Y-G2-3 YIA
Involvement of microRNA-133a-3p with the conversion of muscle fiber typein human skeletal myogenesis.
Zhou Yuhang1, Yoshinori Ichihara1, Hirotaka Iwasaki2, Agung Kurniawan Priyono1,
Tatsuya Sawano1, Keiko Nagata1, Junichiro Miake1, Hidetoshi Sakurai3, Takeshi Imamura1
1

Tottori University, Pharmacology Department, 2Shiga Medical Unicersity, Pharmacology Department, 3Kyoto
University, iPS Cell InstituteCopyright © The Japanese Pharmacological Society2-Y-G2-4 YIA
Pyro-drive jet injector (PJI) as a novel gene transfer approach to muscle
tissues
Takafumi Nakae1, Masanori Obana1,2, Takahiro Maeda1, Hiroshi Miyazaki3, Kazuhiro Terai3,
Yasushi Fujio1,2
1

Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical sciences, Osaka University,
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research
Initiatives (OTRI), Osaka University, 3Medical Device Division, Innovation and Business Development
Headquarters, Daicel Corporation2

Copyright © The Japanese Pharmacological Society2-Y-G3-1 YIA
Topical treatment of Mastic significantly ameliorates inflammatory andpruritic response in a mouse model of atopic dermatitis.
Kishimoto Risako1, Mayuka Koike1, Naoki Iwashita1,2, Tomoki Fukuyama1
1

Lab.Veterinary pharmacology,Sch.Veterinary Medicine,Azabu Univ.,2Bioalchemis

Copyright © The Japanese Pharmacological Society2-Y-G3-2 YIA
15d-Prostaglandin J2 inhibits noncanonical inflammasome response toameliorate endotoxin shock.
Manabu Taura, Ryosuke Sasaki, Naoki Takemura, Tatsuya Saitoh
Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University

Copyright © The Japanese Pharmacological Society2-Y-G3-3 YIA
Bitter taste receptor signaling facilitates neutrophil migration
Daichi Kobayashi1, Atsumasa Tohda1, Madoka Ozawa1, Yasuhiro Kanda1, Arata Takeuchi1,
Fumihiro Saika2, Norikazu Kiguchi2, Shinsuke Matsuzaki3, Tomoya Katakai1
1

Niigata Univ. Med. Dent. Immunol., 2Wakayama Med. Univ. Med. Pharmacol., 3Morinomiya Univ. Med. Sci.
Radiobiol.

Copyright © The Japanese Pharmacological Society2-Y-G3-4 YIA
Clarification of pathophysiological roles that suppressed Th2 cytokine
response by Aquaporin-5
Keisuke Osada, Kanta Fujikawa, Takumi Okaya, Yoichiro Isohama
Lab. appl. Pharmacol., Fac. of Pharm. Sci., Tokyo univ. of Sci

Copyright © The Japanese Pharmacological Society2-Y-G3-5 YIA
Role of NKT cells in liver repair after hepatic ischemia-reperfusion injury inmice
Goto Takuya1,2,3, Yoshiya Ito1,2, Masashi Satoh4, Shuji Nakamoto1,2,3, Kanako Hosono1,2,
Ko Hatanaka1,2, Hideki Amano1,2
1

Dept. of Mol. Pharmacol., Kitasato Univ. Grad. Sch. of Med. Sci., 2Dept. of Pharmacol., Kitasato Univ. Sch. ofMed, 3Dept. of Surg., Kitasato Univ. Sch. of Med., 4Dept. of Immunol., Kitasato Univ. Sch. of Med

Copyright © The Japanese Pharmacological Society