3-P-188
A novel neuro-vascular culture system revealed that the damage of vascular
cells by Alzheimer's amyloid-β assemblies, amylospheroids, increases theexpression of BACE protein through endothelial cells-derived angiotensin II
releaseTomoya Sasahara1,2, Minako Hoshi1,31Depart. Brain and Neurodegener. Disease Res., FBRI at Kobe, 2Res. & Development Div., TAO Health Life
Pharma, 3Depart. Anat. and Dev. Biol., Graduate School of Medicine, Kyoto Univ.

Copyright © The Japanese Pharmacological Society3-P-189
Hypercholesterolemia may play protectively against cerebral aneurysms
Kazuya Hokamura1, Hiroshi Makino3, Takayuki Iwaki2, Ryo Imai3, Sho Sugimura3,
Yoshiki Nakajima3, Kazuo Umemura2
1

Medical Edu., Hamamatsu Univ. Sch. of Med., 2Dept. Pharm., Hamamatsu Univ. Sch. of Med., 3Dept., Anesth.,Hamamatsu Univ. Sch. of Med.

Copyright © The Japanese Pharmacological Society3-P-190
Analysis of pericytes derived from the stroke-prone spontaneously
hypertensive rats
Shinsuke Nakagawa, Junichi Matsumoto, Atsushi Yamauchi
Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-P-191
Suppressive effects of cervical lymph nodes excision on pathology ofischemic cerebral stroke
Akira Takahashi, Naotaka Izuo, Takashi Asano, Atsumi Nitta
Dept. Pharm Therap and NeuroPharm, Grad. Sch. Med. Pharm Sci., Toyama Univ.

Copyright © The Japanese Pharmacological Society3-P-1922+

Ischemia-induced Zn accumulation is modulated by EAAT3 diurnal
fluctuation in the hippocampus
Takaaki Aratake1,2, Youichirou Higashi1, Takahiro Shimizu1, Shogo Shimizu1, Suo Zou1,
Rina Nakamura1, Toshifumi Akizawa1, Motoaki Saito1
1

Dept. of Pharmacol., Kochi Med. Sci., Kochi Univ., 2JSPS Research Fellow

Copyright © The Japanese Pharmacological Society3-P-193
Brain pericytes promote brain endothelial DHA uptake through inducing
membrane expression of the transporter MFSD2A
Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Shinya Dohgu
Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-P-194(+)-Hopeaphenol inhibits Poly IC-induced innate immunity activation via IFNβ in human cerebral microvascular endothelial cells
Zaiqiang Yu1, Xu Liu1, Tadaatsu Imaizumi2, Shogo Kawaguchi2, Haruhisa Kikuchi3,
Kazuyuki Daitoku1, Masahito Minakawa1, Shigeru Motomura4, Ken-ichi Furukawa5,
Yoshiteru Oshima6, Kazuhiko Seya2
1

Dept. Thorac. Cardiovasc. Surg., Hirosaki Univ. Grad. Sch. Med., 2Dept. Vascul. Biol., Hirosaki Univ. Grad. Sch.
Med., 3Keio Univ. Facul. Pharm., 4Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med., 5Dept. Orthop. Surg.,
Hirosaki Univ. Grad. Sch. Med., 6Grad. Sch. Pharmaceut. Sci., Tohoku Univ.

Copyright © The Japanese Pharmacological Society3-P-195
Effects of mizagliflozin, a selective SGLT1 inhibitor, on chronic
hypoperfusion-induced vascular cognitive impairment.
Nanae Ishida1, Maki Saito2, Sachiko Sato3, Yu Tezuka4, Atsushi Sanbe4, Eiichi Taira3,
Masamichi Hirose1
1

Div. Mol. Cell. Pharmacol., Dept. Pathophysiol. Pharmacol., Iwate Medical Univ., 2Sch. Pharm., Iryo Sosei Univ.,
3
Dept. Pharmacol., Iwate Medical Univ., 4Div. Pharmacotherapeutics., Dept. Pathophysiol. Pharmacol., Iwate
Medical Univ.

Copyright © The Japanese Pharmacological Society3-P-196
Establishment of a mouse model of spinocerebellar ataxia type 34
Morikawa Yuri1, Takahiro Seki1, Ayumu Konno2, Hirokazu Hirai2, Yuki Kurauchi1, Hiroshi Katsuki1
1

Dept Chemico-Pharmacol Sci, Grad Sch Pharm Scu, Kumamoto Univ, 2Dept Neurophysiol Neural Rep, Gunma
Univ Grad Sch Med

Copyright © The Japanese Pharmacological Society3-P-197
Involvement of P-glycoprotein in α-Synuclein aggregate-induced
inflammatory mediator release by brain pericytes
Shinya Dohgu1, Miki Yokoya1, Minami Akizuki1, Atsushi Kobayashi1, Fuyuko Takata1,
Takuro Iwao1, Junichi Matsumoto1, Hisataka Aridome1, Miho Yasunaga1, Kazunori Sano2
1

Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2Dept. Physiol. & Pharmacol., Fac.
Pharmaceut. Sci., Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-P-198
Cyclophillin A is involved in the uptake of oligomericα-synuclein by brain
pericytes
Miki Yokoya, Fuyuko Takata, Takuro Iwao, Junichi Matsumoto, Miho Yasunaga,
Hisataka Aridome, Shinya Dohgu
Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.,

Copyright © The Japanese Pharmacological Society3-P-199
Fosl1 gene expression in the mouse hippocampus of earlier stages of
epileptogenic processes
Rie Komori1, Taira Matsuo1, Yasuhiro Ishihara2, Kouichi Itoh1
1

Kagawa Sch. Pharmaceut. Sci., Tokushima Bunri Univ., 2Grad. Sch. Integr. Sci. Life, Hiroshima Univ.

Copyright © The Japanese Pharmacological Society3-P-200
Dopamine decreases LPS-induced expression of proinflammatory cytokines
in microglial cells through the formation of dopamine quinone in the mousestriatum.
Yasuhiro Yoshioka, Yuta Sugino, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., Osaka 573-0101, Japan

Copyright © The Japanese Pharmacological Society3-P-201
PM226, a cannabinoid CB2 receptor agonist, protects retinal ganglion cells
against excitotoxicity in the mice
Kenji Sakamoto, Takatoshi Kobayashi, Asami Mori, Takashi Uezono
Lab. Med. Pharmacol., Fac. Pharma-Sci., Teikyo Univ.

Copyright © The Japanese Pharmacological Society3-P-202
Insulin promotes expression of MIDN, a novel genetic risk factor for
Parkinson‘s Disease, mediated through AP-1
Yutaro Obara, Naoki Sagehashi, Ohki Maruyama, Kuniaki Ishii
Dept. Pharmacol. Yamagata Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society3-P-203
Analysis of the dynamics of primary cilia in a humanized APP mouse model
Yumiko Saito1, Shogo Kobuchi1, Talaomi Saido2, Takashi Saito3, Yuki Kobayashi1
1Grad. Sch. Integ. Sci Life, Hiroshima Univ., 2Lab. Proteolytic Neurosci. RIKEN Cent. Brain Sci., 3Dept. Neurocog.
Sci. Inst. Brain Sci. Nagoya City Univ.

Copyright © The Japanese Pharmacological Society3-P-204
The effect of ALS-related mutation on lipid binding of sigma-1 receptor andits relationship with agonist action
Yasuharu Shinoda1, Yudai Haga1, Takuya Sasaki1, Kohji Fukunaga21Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Tohoku Univ., 2Dept. CNS Drug Innov., Grad. Sch. Pharmaceut.
Sci., Tohoku Univ.

Copyright © The Japanese Pharmacological Society3-P-205
5-Lipoxygenase inhibitors suppressed the neurotoxicity of secretory
phospholipase A2
Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma
Dept. Pharmaceutic. Health, Himeji Dokkyo Univ.

Copyright © The Japanese Pharmacological Society3-P-206
Short-term intranasal administration of rotenone provides a useful mousemodel with chemosensory and mild cognitive impairments.
Hajime Sato1, Keitaro Satoh1, Hiroki Toyoda2, Ayano Katagiri2, Takafumi Kato2, Kazunori Adachi11Div. Pharmacol., Meikai Univ. Sch. Dent., 2Dep. Oral Phys., Osaka Univ. Sch. Dent.

Copyright © The Japanese Pharmacological Society3-P-207
Identification of a novel sleep-regulating factor by in vivo screening of
neurodegenerative disease-related factors
Kosei Yamaura1,2, Daisuke Tone2, Rikuhiro Yamada1,2, Hiroki Ueda1,2,3
1

Laboratory of Systems Biology, Graduate School of Medicine, Osaka University, 2Laboratory for Synthetic Biology,
RIKEN Center for Biosystems Dynamics Research, 3Department of Systems Pharmacology, Graduate School of
Medicine, The University of Tokyo

Copyright © The Japanese Pharmacological Society3-P-208
Role of noradrenergic transmission within the ventral bed nucleus of thestria terminalis in nicotine withdrawal-induced aversive behavior
Saya Arakaki, Masabumi Minami
Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society3-P-209
Effects of the cannabinoid CB1 receptor antagonist AM251 on sensorimotor
gating deficits during withdrawal in mice repeatedly administered withmethamphetamine
Ryo Fukumori, Kensaku Ohta, Taku Yamaguchi
Dept. Pharmacother. and Neuropsychopharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.

Copyright © The Japanese Pharmacological Society3-P-210
Changes in miR-7020-5p expression in methamphetamine-induced
rewarding effectKeisuke Mizuo, Tomoka Yamaguchi, Satoshi Watanabe
Department of Legal Medicine, Sapporo Medical University

Copyright © The Japanese Pharmacological Society3-P-211
Effects of pretreatment with a glycogen synthase kinase-3 inhibitor on
methamphetamine-induced hyperlocomotion, stereotypy and reward in mice
Nobue Kitanaka1, Junichi Kitanaka1, Kazuo Tomita2, Kento Igarashi2, Koh-ichi Tanaka3,
Takuma Hashimoto1, Kai Hirabayashi1, Utau Horie1, Kenta Iwasaki1, Yumi Kawasaki1,
Minami Kimura1, Takashi Sakamoto1, Junya Yashiro1, Nobuyoshi Nishiyama3, Tomoaki Sato2
1

Dept. Pharmacol, Hyogo Col. Med., 2Dept. Applied Pharmacol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ,
Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci.

3

Copyright © The Japanese Pharmacological Society3-P-212
Glycogen synthase kinase-3 inhibitors suppress morphine-induced Straub‘stail reaction via a centrally acting mechanism
Junichi Kitanaka1, Nobue Kitanaka1, Kazuo Tomita2, Kento Igarashi2, Koh-ichi Tanaka3,
Takuma Hashimoto1, Kai Hirabayashi1, Utau Horie1, Kenta Iwasaki1, Yumi Kawasaki1,
Minami Kimura1, Takashi Sakamoto1, Junya Yashiro1, Nobuyoshi Nishiyama3, Tomoaki Sato2
1

Dept. Pharmacol, Hyogo Col. Med., 2Dept. Applied Pharmacol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ,
Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci.

3

Copyright © The Japanese Pharmacological Society3-P-213
Suppressive effects of glatiramer acetate on the addiction induced bymethamphetamine via upregulation of osteopontin in mice
Ryusuke Tamatani, Naotaka Izuo, Takumi Nakajima, Atsumi Nitta
Dept. of Pharmaceut. Therapy & Neuropharmacol. ,Fac. of Pharmaceut. Sci. , Grad. Sch. of Med. and Pharmaceut.
Sci. , Univ. of Toyama

Copyright © The Japanese Pharmacological Society3-P-214Distinct role of dopamine in the PFC and NAc during exposure to cocaineassociated cues
Yukie Kawahara1, Yoshinori Ohnishi1, Yoko Ohnishi1, Hiroshi Kawahara2, Akinori Nishi1
1

Dept. of Pharmacol., Kurume Univ. Sch. of Med., 2Dept. of Dent. Anesthesiology, Tsurumi Univ. Sch. of Dent. Med.

Copyright © The Japanese Pharmacological Society3-P-215
Cognitive dysfunction and hippocampal synaptic impairment induced bymethamphetamine locally injection into the nucleus accumbens
Tokuhara Reika, Naotaka Izuo, Yuka Kusui, Takashi Asano, Atsumi Nitta
Dept. Pharm Therap and NeuroPharm. Fac. Pharm., Toyama Univ.

Copyright © The Japanese Pharmacological Society3-P-216
Construction of the ELISA assay to quantify Semaphorin 3A in the adultbrain
Naoya Yamashita1,2,3, Yui Mizutani2, Aoi Jitsuki-Takahashi3,4, Ke-Yi Lin5, Fumio Nakamura3,4,
Takashi Sakurai2, Yoshio Goshima3
1

Dept. of Applied Biosci., Kanagawa Institute of Technology, 2Dept. of Cell and Mol Pharmacol., Juntendo Univ.,
Sch. Med., 3Dept. Mol Pharmacol and Neurobiol, Grad. Sch. Med., Yokohama City Univ., 4Dept. Biochem, Tokyo
Women's Medical Univ, 5Chiome Bioscience

Copyright © The Japanese Pharmacological Society3-P-217
Acute intracerebroventricular injection of an eEF2K inhibitor lowers
systemic blood pressure in hypertensive rats
Atsunori Yamamoto, On Uezawa, Tomoko Kodama, Kosuke Otani, Muneyoshi Okada,
Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch., Vet. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society3-P-218
Cyclosporin A stimulates brain pericytes to induce inflammatory mediators
related to blood-brain barrier dysfunction
Arisa Fukuyama1, Fuyuko Takata1, Takuro Iwao1, Miki Yokoya1,2, Miho Yasunaga1,2,
Naotaka Aridome1, Yuko Fukunaga3, Shinya Dohgu11Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2Dept. Pharmaceut. Care & HealthSci., Fac. Pharmaceut. Sci., Fukuoka Univ., 3Office for female researchers, Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-P-219
PKC domains involved in propofol-induced PKC translocation
Soshi Narasnarasaki1,4, Soma Noguchi1, Tomoaki Urabe1,4, Kana Harada1, Izumi Hide1,
Sigeru Tanaka1, Yuki Yanase2, Taketoshi Kajimoto3, Norio Sakai1
1Dept of Mol & Pharmacol Neurosci, Grad Sch of Biomed & Health Sci, Hiroshima Univ, 2Dept ofPharmacotherapy, Grad Sch of Biomed & Health Sci, Hiroshima Univ, 3Div of Biochem, Dept of Biochem and Mol
Critical Care, Grad Sch of Biomed & Health Sci,
Biol, Kobe Univ Grad Sch of Med, 4Dept of Anesthesiology
Hiroshima Univ

Copyright © The Japanese Pharmacological Society3-P-220
Spatiotemporal analysis of propofol-induced PKC translocation -Subcellular
Localization of PKC Activation by propofolSoma Noguchi1, Taketoshi Kajimoto4, Tomoaki Urabe2, Yuki Yanase3, Soshi Narasaki1,2,
Kana Harada1, Shigeru Tanaka1, Izumi Hide1, Norio Sakai1
1Dept. of Mol. & Pharmacol. Neurosci. ,Grad. Sch. of Biomed. & Health Sci. ,Hiroshima Univ., 2Dept. ofAnesthesiology & Critical Care ,Grad. Sch. of Biomed. & Health Sci. ,Hiroshima Univ., 3Dept. of
Pharmacotherapy ,Grad. Sch. of Biomed. & Health Sci. ,Hiroshima Univ., 4Div. of Biochem. , Dept. of Biochem.
and Mol. Biol. , Kobe Univ. Grad. Sch. of Med.

Copyright © The Japanese Pharmacological Society3-P-221
Vonoprazan decreases tight junction-associated proteins at the blood-brain
barrier
Sawa Tachibana, Saki Tanaka, Fuyuko Takata, Takuro Iwao, Junichi Matsumoto,Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Shinya Dohgu
Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-P-222
Decreased brain uptake of cyclosporin A and tacrolimus in the inflammatory
bowel disease mice.
Fuyuko Takata, Yuko Yoshinaga, Takuro Iwao, Shinya Dohgu
Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-P-223
Maternal obesity disturbs nurturing behaviors in mice
Tomohiro Kamata, Daiki Ueda, Naomi Yonemochi, Hiroko Ikeda
Dept. Pathophysiol. Ther., Hoshi Univ. Sch Pharm Pharmaceut. Sci.

Copyright © The Japanese Pharmacological Society3-P-224
Involvement of Peripheral PACAP-PAC1 Receptor Signaling System to ItchSensation in Atopic dermatitis mice
Tomohiro Nakayama1, Ryuta Ikeda1, Syo Kato1, Takuya Okada2, Naoki Toyooka2, Atsuro Miyata3,
Takashi Kurihara3, Ichiro Takasaki1
1Dept. Pharmacol., Grad. Sch. Eng. Sci., Univ. Toyama, 2Dept. Bio-func. Mol. Eng., Grad. Sch. Eng. Sci., Univ.
Toyama, 3Dept. Pharmacol., Grad. Sch. Med. Dent., Univ. Kagoshima

Copyright © The Japanese Pharmacological Society3-P-225
Analgesic effect of topical application of TRP antagonists to gingiva on
orthodontic force-induced pain in rats
Misato Yugawa1, Keitaro Satoh2, Au Sasaki1, Naoto Suda1, Kazunori Adachi2
1Div. Orthodont. Meikai Univ. Sch. Dent., 2Div. Pharmacol. Meikai Univ. Sch. Dent.

Copyright © The Japanese Pharmacological Society3-P-226
Mechanisms of early afterdepolarization-mediated lethal arrhythmias inpatients with long QT syndrome type II: an in silico study
Kunichika Tsumoto1, Takao Shimamoto2, Yuma Aoji2, Yu-ichi Kuda1, Mamoru Tanida1,
Akira Amano2, Yasutaka Kurata1
1

Dept. Physiol II, Kanazawa Med. Univ., 2Dept. Bioinfo, Coll. Life Sci, Ritumeikan Univ.

Copyright © The Japanese Pharmacological Society3-P-227hERG channel inactivation and drug binding
Kazuharu Furutani1,2, Jan Jan2, Vladimir Yarov-Yarovoy2
1

Tokushima Bunri Univ., Dept. Pharmacol., 2Univ. California, Davis, Depart. Physiol & Memb. Biol.

Copyright © The Japanese Pharmacological Society3-P-228
Evaluation of RyR2 inhibitors as anti-arrhythmic drugs using novel CPVT
model mice
Koichiro Ishii1, Nagomi Kurebayashi1, Masami Kodama1, Takashi Murayama1, Mai Takenaka1,
Yuta Okabe2, Nobuyuki Murakoshi2, Mari Yuasa-Ishigami3, Shuichi Mori3, Masami Sugihara4,
Takuya Kobayashi1, Hiroyuki Kagechika3, Takashi Sakurai11

Dept. Pharmacol., Fac. Med., Juntendo Univ., 2Dep. Cardiol., Fac. Med., Univ. of Tsukuba, 3IBB, Tokyo Med. Dent.
Univ., 4Dept. Clin., Lab. Med., Juntendo Univ.

Copyright © The Japanese Pharmacological Society3-P-229
Enhanced susceptibility to catecholamine-induced arrhythmias in CNNM2deficient mice
Hideaki Tagashira1, Takayuki Nemoto1, Tomo Kita1, Satomi Kita1,2, Takahiro Iwamoto1
1

Dept. Pharmacol., Fac. Med., Fukuoka Univ., 2Dept. Pharmacol., Fac. Pharmaceut. Sci., Tokushima Bunri Univ.

Copyright © The Japanese Pharmacological Society3-P-230
Protective effect of N-acetylcysteine against the cytoskeletal injury inducedby cigarette tobacco extract and heated tobacco products in C2C12
myoblasts
Otsu Wataru1, Naoki Chinen2, Kodai Ishida1, Shinsuke Nakamura2, Masamitsu Shimazawa1,2,3,Hideshi Tsusaki1, Hideaki Hara2,3
1

Dept. Biomed. Res. Lab., Gifu Pharm. Univ., 2Mol. Pharmacol., Dept. Biofunc. Eval., Gifu Pharm. Univ., 3Lab.
Collabo. Res. Innov. Drug Disc., Gifu Pharm. Univ.

Copyright © The Japanese Pharmacological Society3-P-231

Copyright © The Japanese Pharmacological Society3-P-232
2+

Relationship between synchronized tissue-wide Ca oscillations and bloodflow fluctuations induced by acetylcholine in rat submandibular gland
Akihiro Nezu1, Takao Morita2, Hisayoshi Ishii3, Takeharu Nagai4, Akihiko Tanimura1
1

Div Pharmacol, Health Sci. Univ. Hokkaido Sch. Dent., 2Dept. Biochem., Nippon Dent. Univ. at Niigata, 3Div
Physiol, Health Sci. Univ. Hokkaido Sch. Dent., 4Inst. Sci., Ind. Res., Osaka Univ.

Copyright © The Japanese Pharmacological Society3-P-233
Centrally administered corticotropin-releasing factor facilitates the rat
micturition reflex via brain glutamatergic receptors
Takahiro Shimizu1, Yurika Hata1,2, Suo Zou1, Masaki Yamamoto3, Hideaki Ono1,2,
Yohei Shimizu1,2, Takaaki Aratake1,4, Shogo Shimizu1, Youichirou Higashi1, Motoaki Saito1
1

Dept. Pharmacol., Kochi Med. Sch., Kochi Univ., 2Ctr. Innov. and Translational Med., Kochi Med. Sch., Kochi
Univ., 3Dept. Ped., Kochi Med. Sch., Kochi Univ., 4Res. Fellow of JSPS

Copyright © The Japanese Pharmacological Society3-P-234
Effects of temozolomide and PCPA on micturition function in mice with anenriched environment
Fumio Soeda, Shuuki Moriyama, Takayuki Koga, Yuko Kobuke, Akihisa Toda
Daiichi Univ. Pharm.

Copyright © The Japanese Pharmacological Society3-P-235
Effects of reactive oxygen species on hepatic indoxyl sulfate production
Shuhei Kobuchi, Asuna Takeuchi, Tomohiro Ohta, Souta Bandou
Div. Pharmacol, Dept. Pharm., Hyogo Univ. Health Sci.

Copyright © The Japanese Pharmacological Society3-P-236
Involvement of Indoxyl Sulfate in Vascular Endothelial Dysfunction
associated with Ischemic Acute Kidney Injury
Keisuke Nakagawa1, Masahide Donouchi1, Masaya Kanda1, Saaya Kamada1, Shuhei Kobuchi2,
Ryosuke Tanaka1, Masashi Tawa1, Yasuo Matsumura1, Mamoru Ohkita1
1

Dept. Pathol. & Mol. Pharmacol, Fac. Pharm, Osaka Med. & Pharmaceut. Univ., 2Div. Pharmacol, Dept. Pharm.
Sch. Pharm, Hyogo Univ. Health Sci.

Copyright © The Japanese Pharmacological Society3-P-237
Evaluation of urinary biomarkers in ischemia/reperfusion-induced renal
injuryKeiko Hosohata1, Denan Jin2, Shinji Takai2
1Osaka Medical and Pharmaceutical University, 2Osaka Medical and Pharmaceutical University

Copyright © The Japanese Pharmacological Society3-P-238
Evaluation of micturition function of water load model using cynomolgus
monkeyYasuda Hitoshi, Takashi Sakuraba, Tomohiko Yamanouchi, Tomohiro Katayose,
Sachi Okabayashi, Noriyuki Yamazaki, Chihomi Mitsuoka, Shunichi Kitajima
New Drug Research Center, Inc.

Copyright © The Japanese Pharmacological Society3-P-239
Interaction of AGN-1, which binds to protein phosphatase 6, with tau
alternative splicing variants mRNAs in neuroblastoma cells
Ryoji Kojima, Hinako Osada, Rina Yamamoto
Lab. of Anal. Pharmacol. Fac. of Pharm. Meijo Univ.

Copyright © The Japanese Pharmacological Society3-P-240
A candidate molecule for non-invasive biomarkers in renal Nrf2 activation
Haruka Takayama, Ayae Tanaka, Hiroko Sonoda, Masahiro Ikeda
Lab. Vet. Pharmacol., Univ. of Miyazaki

Copyright © The Japanese Pharmacological Society3-P-241
Downregulation of progesterone receptor membrane component 1(PGRMC1) enhances cyclooxygenase 2 expression via upregulating FOXO1
expression in the process of human endometrial stromal cells differentiation
Atsuya Tsuru1, Mikihiro Yoshie1, Junya Kojima2, Ryota Negishi1, Ryo Yonekawa1,
Kazuya Kusama1, Mana Azumi1, Hirotaka Nishi2, Kazuhiro Tamura1
1Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. and Life Sci., 2Dept. Obstet. Gynecol., Tokyo Med. Univ.

Copyright © The Japanese Pharmacological Society3-P-242
The number of litters in V1aR-KO mice decreased due to the abnormal
growth of the fetus in utero
Hiroyoshi Tsuchiya, Morio Azuma, Yuta Mochimaru, Taka-aki Koshimizu
Div. of Mol. Pharmacol., Dept. of Pharmacol., Jichi Med. Univ.

Copyright © The Japanese Pharmacological Society3-P-243
Intracochlear inflammation reduces the number of synapses between innerhair cells and the cochlear nerve
Taro Yamaguchi, Mayuko Uemura, Yusuke Onaka, Masanori Yoneyama
Lab. Pharmacol., Fac. Pharm. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society3-P-244
Gene expression profiles in lacrimal glands after retinal damage of mice
Yuta Ohno1, Tomohiro Yako2, Keitaro Satoh1,3, Haruna Nagase1, Akiko Shitara1, Hideaki Hara2,
Masanori Kashimata1
1

Dept. Pharmacol., Asahi Univ. Sch. Dent., 2Mol. Pharmacol., Gifu Pharmaceut. Univ., 3Dept. Pharmacol., Meikai
Univ. Sch. Dent.

Copyright © The Japanese Pharmacological Society3-P-245
Rapamycin attenuates noise-induced hearing loss by promoting autophagyin the cochlear lateral wall
Masanori Yoneyama, Masanori Nakatani, Taro Yamaguchi, Yusuke Onaka
Lab. Pharmacol., Fac. Pharmaceut. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society3-P-246
Valproic acid accelerates the developmental cell death and delays thesynaptogenesis in the mouse retina
Akane Morita1, Naganobu Masuda1, Moeko Sakaguchi1, Naoto Iizuka1, Toshihide Kashihara1,
Asami Mori1,2, Kenji Sakamoto1,2, Tsutomu Nakahara1
1Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2Lab. Med. Pharmacol., Fac. Pharma-Sci., Teikyo Univ.

Copyright © The Japanese Pharmacological Society3-P-247
Endogenous apelin is protective against retinal dysfunction in type 1
diabetic Akita mice
Yuki Ishimaru, Masato Mikazuki, Yurina Okamoto, Yume Naiki, Yuka Fukuoka, Akiko Yamamuro,Yasuhiro Yoshioka, Sadaaki Maeda
Lab. Pharmacotherap., Fac. Pharmaceut. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society3-P-164
Suppression of M1 macrophage activation and osteoclast differentiation by
Apocynaceae plant extract
Chika Ishida1, Miren Suzuki1, Tetsuya Seto1,2, Marina Otsuka1, Hiroki Sakai1, Masatoshi Takeiri3,
Yukino Tsunekage3, Keiko Arai3, Takeshi Honda1, Yoshihide Kimura3, Masataka Asagiri11Dept. Pharmacol. Yamaguchi Univ. Grad. Sch. Med., 2Dept.Orthopedic Surg. Yamaguchi Univ. Grad. Sch. Med.,3
IVY Cosmetics

Copyright © The Japanese Pharmacological Society3-P-248
Synthetic retinoid bexarotene inhibits differentiation of inflammatory
osteoclasts
Takegami Hina, Hiyori Nakamura, Ayano Takeda, Mayu Matsuo, Hiroki Sakai, Takeshi Honda,
Masataka Asagiri
Dept. Pharmacol. Yamaguchi Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society3-P-249
Inhibitory effect of spermidine on differentiation of inflammatory osteoclasts
Tanaka Seiya1, Asuka Okamoto1, Honoka Tsubaki1, Tetsuya Seto1,2, Hiroki Sakai1,
Takeshi Honda1, Masataka Asagiri11Dept. Pharmacol. Yamaguchi Univ. Grad. Sch. Med., 2Dept.Orthopedic Surg. Yamaguchi Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society3-P-250
Effect of Novel Women's Preservative Herbal Medicine on locomotive
syndrome of OVX mice
Megumi Furukawa1, Ryoken Aoki2, Masahiro Toho2, Takeaki Nitto2, Yasuo Watanabe3,
Nobuo Izumo2,4
1

Ctr. for Pharmaceut. Educ., Yokohama Univ. of Pharm.,2Lab. of Pharmacotherapy, Yokohama Univ. of Pharm.,
3
General Health Med. Ctr., Yokohama Univ. of Pharm.,4General Health Med. Res. Ctr., Yokohama Univ. of Pharm.

Copyright © The Japanese Pharmacological Society3-P-251
C-type natriuretic peptide stimulates bone growth by potentiating autonomic2+
Ca entry in growth plate chondrocytes
Yuu Miyazaki, Atsuhiko Ichimura, Ryo Kitayama, Naoki Okamoto, Tomoki Yasue, Feng Liu,
Takaaki Kawabe, Hiroki Nagatomo, Miyuki Nishi, Sho Kakizawa, Hiroshi Takeshima
Dept. Biol. Chem., Grad. Sch. Pharmaceut. Sci., Kyoto Univ.

Copyright © The Japanese Pharmacological Society3-P-252
Osteogenetic effects of KY-273, a diphenylether derivative, in mesenchymal
stem cells and ovariectomized rats.
Megumi Yamamoto1,2, Yuma Ito2, Masaki Fukui2, Takanori Yamada3, Tatsuya Kitao2,
Hiroaki Shirahase2, Eiichi Hinoi1,31United Graduate school of Drug Discovery and Med. Information Sci., Gifu Univ., 2Drug Discovery Res. Dept.,
Kyoto Pharmaceut. Ind., 3Dept. Bioactive Molecules, Gifu Pharmaceutical Univ.

Copyright © The Japanese Pharmacological Society3-P-253
PARP inhibitor olaparib suppresses osteogenic differentiation in MC3T3-E1
cells.
Sasaki Yuka1,2, Ryusuke Nakatsuka1, Tadashige Nozaki1, Mitsuko Masutani2
1

Dept. Pharmacology, Faculty of Dentistry, Osaka Dental Univ., 2Dept. Molecular and Genomic Biomedicine, Grad.
Sch. Biomed. Sci. & CBMM, Nagasaki Univ.

Copyright © The Japanese Pharmacological Society3-P-254
Morphological and functional modification of PC12 cells by bone matrix
protein osteocalcin
Sen Higashi1, Eika Ando1,2, Akiko Mizokami3, Seiji Watanabe2, Masato Hirata4, Hiroshi Takeuchi1
1Div. Appl. Pharmacol., Kyushu Dental Univ., 2Div. Dental Anesthesiology, Kyushu Dental Univ., 3OBT Res. Ctr.,
Fac. Dental Sci., Kyushu Univ., 4OM Res. Ctr., Sch. Dent. Med., Fukuoka Dental College

Copyright © The Japanese Pharmacological Society3-P-255
Steroidogenesis via multiple purinergic receptors in bovine adrenocorticalfasciculata cells.
Haruhisa Nishi, Rintaro Sugiyama
Dept. Pharmacol., Sch. Med., Jikei Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society3-P-256
2+

Tight regulation of mitochondrial Ca signal by MICU1 in pancreatic β-cells.
Isamu Taiko, Kazunori Kanemaru, Masamitsu Iino
Dept Physiol, Nihon Univ Sch Med

Copyright © The Japanese Pharmacological Society3-P-257
Intracellular signal transduction of melanin concentrating hormone
receptors expressed in the adenohypophysis of a basal actinopterygian fish,
Polypterus senegalus
Morio Azuma, Yuta Mochimaru, Taka-aki Koshimizu
Div. of Mol. Pharmacol., Dept. of Pharmacol., Jichi Med. Univ.

Copyright © The Japanese Pharmacological Society3-P-258
Effect of the amount of crude drug on the pharmacological action of Kampo
Promoting browning of white adipose
medicine “Boufutsushosan”
tissues in high fat diet induced obese mouse
Misakimisaki Nakasone, Takahiro Tanaka, Junji Akaki
Central R&D Laboratory, Kobayashi Pharmaceutical Co., Ltd

Copyright © The Japanese Pharmacological Society3-P-259
Glucose tolerance in mice lacking glutamate decarboxylase 67 in pancreatic
β cells
Shigeo Miyata1, Kento Hibi2, Yuko Nakagawa3, Hideru Obinata4, Kaori Wakamatsu2,
Masahiko Watanabe5, Yoshio Fujitani3, Yuchio Yanagawa1
1

Dept. Gen. Behav. Neurosci., Grad. Sch. Med., Gunma Univ., 2Div. Mol. Sci., Grad. Sch. Sci. Tec., Gunma Univ.,
3Lab. Dev. Biol. Metab., Inst. Mol. Cell. Reg., Gunma Univ., 4Lab. Anal. Instr., Grad. Sch. Med., Gunma Univ.,
5
Dept. Anat., Fac. Med., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society3-P-260
The analysis of Period1 gene expression in vivo and in vitro using a micro
PMT system at the early stage in diabets
Riku Sato1, Megumi Kanai1, Miho Wakamatsu1, Kotomi Kanagaki1, Yoshimitsu Goto1,
Takeshi Yamaguchi2, Norio Iigima2, Kazuko Hamada1, Toshiyuki Hamada1
1

Dept. Pharmaceut. Sci., International Uni. of Health and Welfare., 2Ctr. for Basic Med. Res. , International Uni. of
Health and Welfare.

Copyright © The Japanese Pharmacological Society3-P-261
Senescent brain pericytes induced BBB dysfunction by their senescenceassociated secretory phenotype
Yuki Goto, Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Shinya Dohgu
Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-P-262
Aging-induced changes in mRNA expression of dopaminergic neuronrelated genes in C57BL/6 mouse brain
Eren Tashiro1, Fuyuko Takata1, Takuro Iwao1, Yuko Fukunaga2, Shinya Dohgu11Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2Office for Female Researchers,
Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-P-263
Involvement of alteration of CD36 expression on pilocarpine-induced
salivation in mouse parotid gland
Keitaro Satoh1, Yuta Ohno2, Haruna Nagase2, Masanori Kashimata2, Kazunori Adachi11Dept. Pharmacol., Meikai Univ. Sch. Dent., 2Dept. Pharmacol., Asahi Univ. Sch. Dent.

Copyright © The Japanese Pharmacological Society3-P-264
The actin-nucleating protein Fhod1 in alveolar macrophages
Ayako Miura1, Fumiyuki Sanamatsu1,2, Ryu Takeya1
1

Dept. Pharmacol., Fac. Med., Univ. Miyazaki., Japan, 2Dept. Nutritional Sci., Fac. Human Life Sci., Univ. Shokei.,Japan

Copyright © The Japanese Pharmacological Society3-P-265
Development of diabetic retinopathy model using retinal organoids
Shinsuke Nakamura1, Satoshi Inagaki1,2, Yakumo Aoyama1,2, Kota Aoshima1,2, Wataru Otsu3,
Michinori Funato2, Masamitsu Shimazawa1,3,4, Kazuhiro Takahashi2, Hideaki Hara1,4
1

Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ., 2Dept. Clin. Res., Nati. Hosp. Org., Nagara Med.
Ctr., 3Biomed. Res., Gifu Pharmaceut. Univ., 4Lab. Collabo. Res. Innov. Drug Disc., Gifu Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society3-P-266
Inhibition of endogenous H2S production suppresses the viability of multiple
myeloma cells: application of carbidopa and benserazide capable ofinhibiting cystathionine-β-synthase to treatment of bortezomib-resistantmultiple myeloma
Fumiko Sekiguchi1, Haruka Moriguchi1, Yukiho Fukushima1, Yuriko Iba1, Maho Tsubota1,
Shiori Hiramoto1, Takuya Okada2, Naoki Toyooka2, Hirokazu Tanaka3, Takashi Ashida3,
Itaru Matsumura3, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., 2Grad. Sch. Sci. Technol., Univ. Toyama,3Div.
Hematol. Rheumatol., Kindai Univ. Fac. Med.

Copyright © The Japanese Pharmacological Society3-P-267
A novel VDR agonist upregulates detoxification-related genes in human iPS
cell-derived intestinal organoids
Shigeru Yamada1,2, Hiroyuki Masuno3, Hiroyuki Kagechika3, Aya Tanatani4, Yasunari Kanda1
1

NIHS, 2PEIJ, 3Tokyo Med Dent Univ., 4Ochanomizu Univ.

Copyright © The Japanese Pharmacological Society3-P-268
Analysis of translation factors using public database of breast cancer
patients.
Naoya Hirata, Shigeru Yamada, Yasunari Kanda
Div. Pharmacol., NIHS

Copyright © The Japanese Pharmacological Society3-P-269
A neuropeptide VIP induces cell migration by activating the PI3K pathway
via VPAC2 receptors
Ozasa Kairi1, Satoshi Asano1,2, Misa Yamasaka1, Atsuko Hayata3,4, Takanobu Nakazawa5,
Hitoshi Hashimoto3,4,6,7,8, James Waschek9, Yukio Ago1,2
1Sch. of Dent., Hiroshima Univ., 2Dept. of Cell. Mol. Pharmacol., Grad. Sch. of Biomed. Health Sci., Hiroshima
Univ, 3Lab. of Mol. Neuropharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 4United Grad. Sch. of Child
Dev., Osaka Univ., 5Dept. of Biosci., Tokyo Univ. of Agr.,6Dept. of Mol. Pharmaceut. Sci., Grad. Sch. of Med.,
Osaka Univ., 7Inst. for Datability Sci., Osaka Univ., 8Inst. for Open Transdiscip. Res. Initiatives, Osaka Univ., 9Univ.
of California Los Angeles

Copyright © The Japanese Pharmacological Society3-P-270
BDNF/TRKB axis provokes EMT progression to induce cell aggressivenessvia cross-talk with cancer-associated fibroblasts in human parotid glandcancerKazumasa Moriwaki1, Masaki Wada2, Hiroko Kuwabara3, Yusuke Ayani2, Masaaki Higashino2,
Tetsuya Terada2, Ryo Kawata2, Michio Asahi11Dept. Pharmacol. Fac. Med., Osaka Med. Pharmaceut. Univ., 2Dept. Otorhinolaryngol. Fac. Med., Osaka Med.
Pharmaceut. Univ., 3Dept. Pathol. Fac. Med., Osaka Med. Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society3-P-271
Macrophage differentiation and molecular mechanism in tumor
microenvironment
Lingjia Hong1, Manami Tanaka1, Masato Yasui1, MARIKO HARA-CHIKUMA1
1

Department of Pharmacology, School of Medicine, Keio University, 2Department of Pharmacology, School of
Medicine, Keio University, 3Department of Pharmacology, School of Medicine, Keio University, 4Department ofPharmacology, School of Medicine, Keio University

Copyright © The Japanese Pharmacological Society3-P-272
Azeliragon, a RAGE antagonist, suppresses cell survival and proliferation ofhuman prostate cancer-derived LNCaP cells: Analysis of altered cellsignaling
Naho Shibano1, Akifumi Adachi1, Kohei Wakitani1, Erina Asano1, Fumiko Sekiguchi1,
Takuya Okada2, Hiroyuki Nishikawa1,3, Naoki Toyooka2, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Kindai Univ., 2Grad. Sch. Sci. Enginner., Univ. Toyama,3Res. Dev. Cent., Fuso
Pharmaceut. Ind. Ltd.

Copyright © The Japanese Pharmacological Society3-P-273
Anti-tumor activity of novel cyclic naphthalene diimide derivatives
Yaida Noboru1, Fukuda Hikaru1,3, Sato Shinobu2, Higashi Sen3, Habu Manabu1,
Sasaguri Masaaki1, Tominaga Kazuhiro1, Shigenaga Shiori2, Takeuchi Hiroshi3
1Div. Maxillofacial Surg., Dept. Sci. Phys. Func., Kyushu Dent. Univ., 2Dept. Appl. Chem., & Res. Ctr. Biomicrosens. Tech., Kyushu Inst. Tech.,3Div. Appl. Pharmacol., Dept. Health Promotion, Kyushu Dent. Univ.

Copyright © The Japanese Pharmacological Society3-P-274
Exploration of blood lncRNA biomarkers predicting oxaliplatin-induced
peripheral neuropathy
Atsushi Sakai1, Motoyo Maruyama1,2, Takeshi Yamada3, Hiroshi Yoshida3, Hidenori Suzuki1
1

Dept. Pharmacol., Nippon Med. Sch., 2Div. Lab. Anim. Sci., Nippon Med. School, 3Dept. Gastrointest. HepatoBiliary-Pancreatic Surg., Nippon Med. Sch.

Copyright © The Japanese Pharmacological Society3-P-275
Atrophic effects by leukemia inhibitory factor (LIF) in 85As2 gastric cancercell-inoculated cachexia model: in vitro analysis with C2C12 skeletal muscle
cell line
Tatsuya Nishi1,2, Miki Nonaka2, Kanako Miyano2, Yasuhito Uezono2,3
1

Pharmaceut. Res. Lab., Toray Ind. Inc., 2Dept. Pain Control Res., The Jikei Univ. Sch. Med., 3Dept. Supp. &Palliat. Care Res. Supp. Office, Natl. Cancer Ctr. Hosp. East

Copyright © The Japanese Pharmacological Society3-P-276
Cytotoxicity of arsenite in combination with bufadienolide compounds
against human glioblastoma cell line U-87
Jingmei Li, Bo Yuan, Meiyan Xuan, Hidetomo Kikuchi, Katsuyoshi Sunaga, Shinya Kamiuchi,
Yasuhide Hibino, Hirokazu Matsuzaki, Mari OkazakiFac. Pharm. & Phamceu. Sci., Josai Univ.

Copyright © The Japanese Pharmacological Society3-P-277
Cytotoxic effects of hellebrigenin and arenobufagin against human breast
cancer cells
Bo Yuan1, Yu Zhang2,3, Baolin Bian2, Haiyu Zhao2, Anna Kiyomi4, Hideki Hayashi3, Yui Iwatani3,
Munetoshi Sugiura4, Norio Takagi3, Mari Okazai1
1Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ, 2China Academy of Chinese Medical Sciences, 3Dept. Appl.
Biochem., Tokyo Univ of Pharm & Life Sci, 4Dept. Drug Safety and Risk Management., Tokyo Univ of Pharm & Life
Sci

Copyright © The Japanese Pharmacological Society3-P-278
Differentiation-inducing factor-1 exhibited anti-metastatic effects throughsuppressing tumor cell adhesion to vascular epithelial cells
Masaki Arioka1, Shiori Taura1,2, Fumi Tetsuo1, Toshiyuki Sasaguri1
1Dept. Clin. Pharmacol. Med. Sci. Kyushu Univ, 2Dept. Dent. Anethesiol. Dent. Sci. Kyushu Univ

Copyright © The Japanese Pharmacological Society3-P-279
Differentiation-inducing factor-1 affects cancer-associated fibroblasts (CAF)
in triple negative breast cancer through CXCLs/CXCR2 axis
Fumi Tetsuo, Shiori Taura, Masaki Arioka, Toshiyuki Sasaguri
Dep of Clin Pharm, Graduate School of Med Sci, Kyushu Univ.

Copyright © The Japanese Pharmacological Society3-P-280
Aquaporin 3-targeted cancer therapy using monoclonal antibodies
Mariko Hara-Chikuma, Manami Tanaka
Keio University

Copyright © The Japanese Pharmacological Society3-P-281
Anti-tumor effects of alpha-ray emitting antibodies for uterine serous
carcinoma
Hasegawa Sumitaka
Radiation & Cancer Biol. Group, Natl. Inst. Quantum Sci. & Tech. (QST)

Copyright © The Japanese Pharmacological Society3-P-2822+

miR-7-5p inhibition induces ferroptosis by increasing ROS and Fe inclinically relevant radioresistant cells
Kazuo Tomita1,2, Yoshikazu Kuwahara1,3, Kento Igarashi1,2, Koh-ichi Tanaka1,2,4, Jyunichi Kitanaka4, Nobue Kitanaka4, Akihiro Kurimasa3, Nobuyoshi Nishiyama2, Tomoaki Sato1
1

Dept. Applied Pharm., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 2Div. Pharmacol., Dept. Pharm., Sch.
Pharm., Hyogo Univ. Health Sci., 3Div. Radiation Biol. Med., Facul. Med, Tohoku Med. Pharm. Univ.,4Dept.
Pharmacol., Hyogo Col. Med.

Copyright © The Japanese Pharmacological Society