3-O-B1-1 Oral Sessions
Analyses of Forming Hetero-oligomers and Regulating Signal transductionsof G-Protein Coupled Receptors (GPCRs) Expressed in the Central Nervous
System.
Hakushun Sakairi1, Yuji Kamikubo1, Hikaru Kono1, Kei Yamamoto1, Toshihide Tabata2,
Takashi Sakurai11

Dept. Pharmacol., Juntendo Univ. Sch. of med., 2Fac Eng, Univ Toyama

Copyright © The Japanese Pharmacological Society3-O-B1-2 Oral Sessions
Projection-identified large-scale recording reveals pathway-specificinformation outflow from the subiculum
Takuma Kitanishi1,2, Ryoko Umaba3, Kenji Mizuseki1
1

Dept Physiol, Osaka City Univ Grad Sch Med, 2PRESTO, JST, 3Dept Neurosurg, Osaka City Univ Grad Sch Med

Copyright © The Japanese Pharmacological Society3-O-B1-3 Oral Sessions
Synchronous activity of event and place representations inhippocampal CA1
Kotaro Mizuta1,2, Masaaki Sato2,3,4,5, Yukiko Sekine2,3, Masako Kawano2, Tanvir Islam2,3, YaoLong Li1, Takashi Takekawa2,6, Masamichi Ohkura5, Junichi Nakai5,7, Yasunori Hayashi1,2,5
1

Dept. Pharmacol. Kyoto Univ., 2BSI RIKEN, 3CBS RIKEN, 4Neuropharmacol. Hokkaido Univ, 5Brain Body Sys. Sci.
Inst. Saitama Univ., 6Fac. Inf. Kogakuin Univ., 7Oral Physiol. Grad. Sch. of Dent. Tohoku Univ.

Copyright © The Japanese Pharmacological Society3-O-B1-4 Oral Sessions
Bidirectional regulation by the endocannabinoid in retrieval of fear memory
using the fear conditioning task in mice
Yoko Nawata1, Asami Ueno1, Tsuyoshi Nishioku1, Taku Yamaguchi2
1

Dept. Pharmacol., Fac Pharmaceut. Sci., Nagasaki Intl. Univ., 2Dept. Pharmacother. and Neuropsychopharmacol.,Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.

Copyright © The Japanese Pharmacological Society3-O-B2-1 Oral Sessions
Electroconvulsive seizure before conditioning inhibits fear memory
formation
Rentaro Kurata, Yuichiro Hongo, Chiaki Takeuchi, Miho Ishikawa, Toshinori Sawano,Kazuyoshi Kosaka, Jin Nakatani, Hidekazu Tanaka
Lab. Pharmacol., Grad. Sch. Life Sci., Ritsumeikan Univ.

Copyright © The Japanese Pharmacological Society3-O-B2-2 Oral Sessions
Development of a five-armed bandit task for assessing behavioral flexibility
Ohta Hiroyuki1, Masashi Arake2, Kuniaki Satori3, Yu Takarada3, Tatsuji Takahashi3,
Yasushi Satoh3, Yuji Morimoto2, Toshiaki Ishizuka1
1

Dept. Med., NDMC, 2Dept. Phisol., NDMC, 3Tokyo Denki Univ.

Copyright © The Japanese Pharmacological Society3-O-B2-3 Oral Sessions
Ninjin’yoeito ameliorates behavioral declines in aged C57BL/6J mice
Yosuke Matsubara, Ryota Imai, Shinji Miyazaki, Eisuke Haneda, Yuko Miyama, Yuji Omiya,
Yoshiki Ikeda
Tsumura Kampo Research Laboratories, Tsumura & Co.

Copyright © The Japanese Pharmacological Society3-O-B2-4 Oral Sessions
Closed-loop stimulation of the medial septum terminates epileptic seizures
Yuichi Takeuchi1
1

Dept. Physiol., Grad. Sch. Med. Osaka City Univ., 2Dept. Physiol., Fac. Med., Univ. Szeged

Copyright © The Japanese Pharmacological Society3-O-B2-5 Oral Sessions
MEA measurement in brain organoid
Remi Yokoi1,2, Yuto Ishibashi1, Naoki Matsuda1, Nami Nagafuku1, Ikuro Suzuki1
1

Tohoku Institute of Technology,2JSPS

Copyright © The Japanese Pharmacological Society3-O-C1-1 Oral Sessions
Hearing impairment associated with dysmyelination of the peripheral
cochlear nerve in muscular dystrophy caused by aberrant α-dystroglycan
glycosylation
Shigefumi Morioka1,2,3, Hirofumi Sakaguchi3, Hiroaki Mohri2, Mariko Ikeda4, Motoi Kanagawa5,
Naoaki Saito2, Takehiko Ueyama2
1

Dept. of Otolaryngology, Kyoto City Hosp., 2Lab. of Mol. Pharmacol., Biosignal Research Center, Kobe Univ.,
3
Dept. of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural Univ. of Med., 4Dept. of Clinical Genetics,
Fujita Health Univ. Hosp., 5Dept. of Mol. Cardiovascular Biol. and Pharmacol. Ehime Univ.

Copyright © The Japanese Pharmacological Society3-O-C1-2 Oral Sessions
An attempt to establish an assay system for protective agents against
glutamate-induced neurotoxicity using QNR/D cells, a cell line derived from
quail embryotic neruroretinas
Kenji Sakamoto, Kazuya Katsumata, Asami Mori, Takashi Uezono
Lab. Med. Pharmacol., Fac. Pharma-Sci., Teikyo Univ.

Copyright © The Japanese Pharmacological Society3-O-C1-3 Oral Sessions
Early reactive gliosis at optic nerve head in normal-tension glaucoma
Youichi Shinozaki1,2, Kazuhiko Namekata3, Kenji Kashiwagi4, Nobuhiko Ohno5,6, Eiji Shigetomi1,2,
Takayuki Harada3, Schuichi Koizumi1,2
1

Dept. Neuropharm., Grad. Sch. Med., Univ. Yamanashi, 2YiBIC, Univ Yamanashi, 3Vis. Res. Project., Tokyo Metr.
Inst. Med. Sci., 4Dept. Ophthalmol, Interdiscip. Grad. Sch. Med. Univ. Yamanashi, 5Dev. Ultrastruct. Res., Natl. Inst.
Physiol. Sci., 6Div. Anatomy, Jichi Med. Univ.

Copyright © The Japanese Pharmacological Society3-O-C1-4 Oral Sessions
P2Y1 receptor is a novel target for anti-glaucoma treatment
Hamada Kentaro1, Yoichi Shinozaki1,2, Namekata Kazuhiko3, Nobuhiko Ohno4,5,Takahiko Segawa6, Takayuki Harada3, Kenji Kashiwagi7, Shuichi Koizumi1,2
1

Dept. Neuropharmacol., Interdiscip. Grad. Sch. Med. Univ. Yamanashi,2Cent. Life Sci. Res., Univ. Yamanashi.,Vis. Res. Project, Tokyo Metr. Inst. Med. Sci.,,4Dev. Ultrastruct. Res., Natl. Inst. Physiol. Sci.,, 5Div.Anatomy,Jichi 6
Med.Univ.,, 6The Center for life Science Research, Univ.Yamanashi, 7Dept.Opthalmol.,Interdiscip.Grad.Sch.Med.
Univ.Yamanashi
3

Copyright © The Japanese Pharmacological Society3-O-C2-1 Oral Sessions
Chemogenetic activation of astrocytes in the ventral hippocampus
Eiji Shigetomi, Schuichi Koizumi
Dept. Neuropharmacol. Interdiscipl. Grad. Sch. Med., Univ. Yamanashi

Copyright © The Japanese Pharmacological Society3-O-C2-2 Oral Sessions
Neuronal excitation mechanism through activation of astrocytic P2Y1
receptor.
Suzuki Hideaki1, Eiji Shigetomi1, Yukiho Hirayama1, Fumikazu Sano1, Kenji Tanaka2,Haruhiko Bito3, Schuichi Koizumi1
1Dept Neuropharmacol, Interdiscipl Grad Sch Med, Univ Yamanashi, 2Dept Neuropsych, Keio Univ Sch Med, 3Dept
Neurochem, Grad Sch Med, Univ Tokyo

Copyright © The Japanese Pharmacological Society3-O-C2-3 Oral Sessions
Astrocytic density tunes presynaptically silent synapses
Shutaro Katsurabayashi, Kohei Oyabu, Kotomi Takeda, Kaori Kubota, Takuya Watanabe,
Katsunori Iwasaki
Dept. of Neuropharmacol., Fac of Pharmaceut. Sci., Fukuoka Univ.

Copyright © The Japanese Pharmacological Society3-O-C2-4 Oral Sessions
Differential adrenergic regulation of process formation in cortical and spinal
cord astrocytes
Taisuke Kitano, Ryota Eguchi, Ken-ichi Otsuguro
Lab. Pharmacol. Fac. Vet. Med. Hokkaido Univ.

Copyright © The Japanese Pharmacological Society3-O-C2-5

Oral Sessions
2+

Hydrogen sulfide increases intracellular Ca concentration by inhibition of
mitochondrial respiration in cultured rat spinal cord astrocytes.
Nii Takeshi, Ryota Eguchi, Ken-ichi Otsuguro
Lab. Pharmacol. Fac. Vet. Med. Hokkaido Univ.

Copyright © The Japanese Pharmacological Society3-O-D1-1 Oral Sessions
The physiological alteration of histidine-rich glycoprotein on the miceperinatal period.
Kiyoshi Teshigawara1, Keyue Liu1, Dengli Wang1, Hidenori Wake1, Shuji Mori2, Hideo Takahashi3,
Masahiro Nishibori1
1

Dept. of Pharm., Okayama Univ. Grad. Sch. of Med., Dent. and Pharm. Sci., 2Sch. of Pharm., Shujitsu Univ., 3Dept.
of Pharm., Kinki Univ., Fac. of Med.

Copyright © The Japanese Pharmacological Society3-O-D1-2 Oral Sessions
Molecular mechanisms underlying the agonistic effect of2+
nondihydropyridine FPL64176 on Cav1.2 Ca channels
Mitsuhiko Yamada, Simmon Gomi, Takuro Numaga-Tomita
Dept. Mol. Pharmacol., Shinshu Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society3-O-D1-3

Oral Sessions
2+

Expression analysis of Ca -sensing receptor and TRPC6 channel inmonocrotaline-induced pulmonary hypertensive rats
Kawade Akiko1, Aya Yamamura2, Yoshiaki Suzuki1, Hisao Yamamura1
1Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2Dept. Physiol ., Aichi Med Univ.

Copyright © The Japanese Pharmacological Society3-O-D1-4

Oral Sessions
2++

Role of Ca -activated K channel KCa1.1 in human osteosarcoma spheroids
Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito
Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society3-O-D2-1 Oral Sessions
A mechanism underlying hERG current increase by a blocker
Kazuharu Furutani1,3, Steffen Docken2, Igor Vorobyov1, Colleen Clancy1, Timothy Lewis2,
Jon Sack1
1

Department of Physiology and Membrane Biology, University of California Davis, 2Department of Mathematics,
University of California Davis, 3Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima
Bunri University

Copyright © The Japanese Pharmacological Society3-O-D2-2 Oral Sessions
Involvement of Kir2.1 channels on the migration of mouse bone marrowderived macrophages
Katayama Taiju, Kazuki Maeda, Toshio Yamamura, Yoshiaki Suzuki
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society3-O-D2-3

Oral Sessions+

Role of inward rectifier K channel Kir2.1 in mouse osteoblast differentiation
Hiroaki Kito, Kyoko Endo, Junko Kajikuri, Susumu Ohya
Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society3-O-D2-4 Oral Sessions
Functional expression of TREK-1 channels in human hepatic stellate cells
Akari Deguchi, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society3-O-D2-5 Oral Sessions
Inhibitory mechanism of melatonin on voltage-dependent Kv4.2 channels
Hiroki Mishima, Yoshiaki Suzuki, Hisao Yamamura
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society3-O-E1-1 Oral Sessions
Serotonin neuron-specific transcriptome profiling in chronic SSRI-treatedmice and chronic social defeat stress model mice
Chihiro Andoh1, Masako Hagiwara1, Naoya Nishitani2, Kazuki Nagayasu1, Hisashi Shirakawa1,
Shuji Kaneko1
1

Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 2Lab. Mol. Pharmacol., Inst. Med.,
Pharmaceut., Health Sci., Kanazawa Univ.

Copyright © The Japanese Pharmacological Society3-O-E1-2 Oral Sessions
Modulation of glutamatergic synaptic transmission in the prelimbic medial
prefrontal cortex via delta-opioid receptors
Daisuke Yamada1, Keita Iio2, Hiroshi Nagase2, Akiyoshi Saitoh1
1

Lab Pharmacol, Fac Pharm Sci, 2IIIS, Univ of Tsukuba

Copyright © The Japanese Pharmacological Society3-O-E1-3 Oral Sessions
Prefrontal cortex miR-874-3p prevents lipopolysaccharide-induced
depression-like behavior through inhibition of indoleamine 2,3-dioxygenase
1 expression in mice
Kazuo Kunisawa1, Willy Jaya Suento2,3, Bolati Wulaer2,4, Aika Kosuge1, Tsubasa Iida1,
Hidetsugu Fujigaki2, Yasuko Yamamoto2, Andi Jayalangkara Tanra3, Kuniaki Saito2,4,5,
Toshitaka Nabeshima4,5, Akihiro Mouri1,5
1

Fujita Health University Graduate School of Health Science Department of Regulatory Science for Evaluation &Development of Pharmaceuticals & Devices, 2Fujita Health University Graduate School of Health Science
Department of Disease Control and Prevention, 3Hasanuddin University Faculty of Medicine Department of
Psychiatry, 4Fujita Health University Graduate School of Health Science Advanced Diagnostic System ResearchLaboratory, 5Japanese Drug Organization of Appropriate Use and Research

Copyright © The Japanese Pharmacological Society3-O-E1-4 Oral Sessions
Involvement of Dysfunction of Noradrenergic Neuronal System in the
Depression-Like Behaviors in MAGE-D1 KO Mice
Akihiro Mouri1,6, Mami Hirakawa1, Misato Yokoyama2, Ken Watanabe3, Mari Kimura2,
Ryosuke Isobe1, Kazuo Kunisawa1, Yuko Mori4, Yasuko Yamamoto4, Yukihiro Noda2,6,
Kuniaki Saito4,6, Toshitaka Nabeshima5,61

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Div. Clin. Sci. and Neuropsychopharm., Meijo
Univ. Grad. Sch. Pharm., 3Dept. Bone and Joint Dis., Natl. Ctr. for Geriatrics and Gerontol., 4Dept. Disease
Control & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., 5Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Univ., 6NPO.J-DO.

Copyright © The Japanese Pharmacological Society3-O-E2-1 Oral Sessions
Nicotine attenuated chronic unpredictable mild stress-induced depressivelike behavior via elevation of serum corticosterone level
Masaya Hasegawa1, Akihiro Mouri1,4, Kazuo Kunisawa1, Hisayoshi Kubota1, Hitomi Kurahashi1,
Yasuko Yamamoto2, Kuniaki Saito2,3,4, Toshitaka Nabeshima3,41

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Uni., 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.,
4NPO. J-DO

Copyright © The Japanese Pharmacological Society3-O-E2-2 Oral Sessions
Depression-like behaviors induced by chronic social defeat stress inassociation with myelin abnormalities in the corpus callosum throughmicroglial activation.
Sugawara Yumika1, Kazuo Kunisawa1, Tsubasa Iida1, Sei Saitoh2, Aika Kosuge1, Wulaer Bolati3,4,
Yasuko Yamamoto3, Kuniaki Saito3,4,5, Akihiro Mouri1,5, Toshitaka Nabeshima3,51

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Anatomy II and Cell Biology, Sch.
Medicine, Fujita Health Univ, 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ., 4Dept.
Disease Control & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., 5NPO.J-DO.

Copyright © The Japanese Pharmacological Society3-O-E2-3 Oral Sessions
Multiple spatiotemporal patterns of social stress-induced epigenetic
regulations in microglia
Masayuki Taniguchi1, Kazutoshi Matsushita1, Rei Mishima1, Shiho Kitaoka1, Shigehiro Kuraku2,
Mitsutaka Kadota2, Tomoyuki Furuyashiki1
1

Division of Pharmacology, Kobe University Graduate School of Medicine, 2Laboratory for Phyloinformatics,
RIKEN Center for Biosystems Dynamics Research

Copyright © The Japanese Pharmacological Society3-O-E2-4 Oral Sessions
Chronic social stress alters iron metabolism for resilience
Shiho Kitaoka1, Taichi Tamura1, Yoshio Katayama2, Tomoyuki Furuyashiki11Div. Pharmacol., Grad. Sch. Med., Kobe Univ, 2Dep. Hematol., Med., Kobe Univ

Copyright © The Japanese Pharmacological Society3-O-E3-1 Oral Sessions
Effects of early life stress on emotional behavior and hippocapal function inadolescent
Hyodo Risa, Sara Nannno, Akari Nishiyama, Taiga Akuhara, Eri Segi-Nishida
Dept. Biol. Sci. and Tech., Tokyo Uni. of Sci.

Copyright © The Japanese Pharmacological Society3-O-E3-2 Oral Sessions
The role of neurotrophin-3 in the hippocampal neurogenesis and maturationrelated phenotypes
Kasakura Nanami1, Yuka Murata1, Ryota Someya1, Shiho Kitaoka2, Tomoyuki Furuyashiki2,
Eri Segi-Nishida11Dept. Biol. Sci. and Tech., Tokyo Uni. of Sci, 2Div of Pharmacol., Grad. Sch. of Med., Kobe Univ.

Copyright © The Japanese Pharmacological Society3-O-E3-3 Oral Sessions
Roles of TRPC3 and TRPC6 in the medial prefrontal cortex in theantidepressant-like actions of ketamine
Satoshi Deyama, Katsuyuki Kaneda
Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ.

Copyright © The Japanese Pharmacological Society3-O-E3-4 Oral Sessions
The protective effect of flesinoxan on myelin damage caused bymaladaptation to stress in mice
Kazuhiro Kurokawa1, Kohei Takahashi1, Kazuya Miyagawa 1, Atsumi Mochida-Saito1,
Hiroshi Takeda2, Minoru Tsuji1
1

Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare, 2Dept. Pharmacol., Sch. Pharm. Fukuoka, Int. Univ.
Health and Welfare

Copyright © The Japanese Pharmacological Society3-O-E3-5 Oral Sessions
The positive effect of Hypoxia-inducible factor on peripheral nerve
remyelination.
Yuka Ujiie-Kobayashi, Shuji Wakatsuki, Toshiyuki Araki
Dept. of Peripheral Nervous System Res., NCNP

Copyright © The Japanese Pharmacological Society3-O-E4-1 Oral Sessions
Hypo-serotonergic function is involved in the prenatal valproic acid-induced
behavioral changes and hyper-excitation in the prefrontal cortex of mice
Kurahashi Hitomi1, Mouri Akihiro1,4, Kunisawa Kazuo1, Kubota Hisayoshi1, Hasegawa Masaya1,
Yamamoto Yasuko2, Saito Kuniaki2,3,4, Nabeshima Toshitaka3,41

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Univ., 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.,
4NPO. J-DO

Copyright © The Japanese Pharmacological Society3-O-E4-2 Oral Sessions
Intranasal oxytocin administration improves impaired social behavior in the
POGZ-Q1038R mutant mice
Kitagawa Kohei1, Kensuke Matsumura1, Masayuki Baba1, Momoka Kondo1, Tomoya Takemoto1,
Kazuki Nagayasu1,2, Yukio Ago1,3, Atsushi Kasai1, Kazuhiro Takuma4,5, Hitoshi Hashimoto1,4,6,7,8,
Takanobu Nakazawa1,91Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2Lab. Mol. Pharmacol., Grad. Sch.
Pharmaceut. Sci., Kyoto Univ., 3Lab. Cell. & Mol. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ.,
4
United Grad. Sch. Child Dev., Osaka Univ., 5Dept. Pharmacol., Grad. Sch. Dent., Osaka Univ., 6Div. Biosci., Inst.
Datability Sci., Osaka Univ., 7Transdimensional Life Imaging Div., Inst. Open Transdiscip. Res. Initiatives, Osaka
Univ, 8Dept. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ., 9Dept. Biosci., Tokyo Univ. Agr.

Copyright © The Japanese Pharmacological Society3-O-E4-3 Oral Sessions
Behavioral changes in rats neonatally treated with midazolam: deficits in thesociability and its recovery by acute administration of methylphenidate.
Niikura Ryo1, Akiko Doi1, Tomoyuki Miyazaki1, Kenkichi Takase2, Takahisa Goto1
1

Dept. Anesth. Crit. Care Med., Yokohama City Univ.,2Sch. Med., Jichi Med. Univ.

Copyright © The Japanese Pharmacological Society3-O-E4-4 Oral Sessions
Local injection of D-amino acid oxidase inhibitor into the prefrontal cortex
improves AD/HD-like behaviors of SHRSP/Ezo.
Hiroki Shikanai, Tsugumi Shindo, Sachiko Hiraide, Kenji Iizuka, Takeshi Izumi
Dept. Pharmacol., Health Sci. Univ. Hokkaido.

Copyright © The Japanese Pharmacological Society3-O-E5-1 Oral Sessions
Therapeutic potential of 5-HT2C receptor antagonism for obsessivecompulsive disorder.
1

2

1

1

1

Hatakama Hikari , Nozomi Asaoka , Kazuki Nagayasu , Hisashi Shirakawa , Shuji Kaneko
1

Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 2Dept. Phamacol., Grad. Sch. Med. Sci., Kyoto
Pref. Univ. Med.

Copyright © The Japanese Pharmacological Society3-O-E5-2 Oral Sessions
Striatal TRPV1 activation by acetaminophen improves tardive dyskinesia
induced by dopamine D2 receptor blockers
1

1

2

1

1

Koki Nagaoka , Takuya Nagashima , Nozomi Asaoka , Hiroki Yamamoto , Chihiro Toda ,
1
1
1
1
1
Gen Kayanuma , Soni Siswanto , Kazuki Nagayasu , Hisashi Shirakawa , Shuji Kaneko
1

Dept. Mol. Pharmacol., Grad. Sch. Pharmceut. Sci., Kyoto Univ., 2Dept. Pharmacol., Grad. Sch. Med., Kyoto Pref.
Univ. Med.

Copyright © The Japanese Pharmacological Society3-O-E5-3
withdraw

Oral Sessions

Copyright © The Japanese Pharmacological Society3-O-E5-4 Oral Sessions
INTERACTION BETWEEN CHOLINERGIC AND OPIOID SYSTEMS IN
ALCOHOL SEEKING BEHAVIOR
Anggadiredja Kusnandar
Dept. Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung

Copyright © The Japanese Pharmacological Society3-O-E5-5 Oral Sessions
Animal model for donepezil-induced nausea and vomiting using pica
behavior in mice
Kouichi Yamamoto1, Yuhki Sato2, Kyosuke Kirikihira1, Akito Jotaki1, Ayana Michihara2,
Yumi Miyake2
1

Dept Med Sci Tech, Div Health Sci, Sch Med, Osaka Univ, 2Dept Physical Pharmaceutics, Fukuyama Univ

Copyright © The Japanese Pharmacological Society3-O-F4-1 Oral Sessions
5-hydroxytryptophan supplement recovers impaired platelet aggregation in
Quinonoid dihydropteridine reductase deficient mice
Yui Suganuma1, Taiki Kano1, Kazuhisa Ikemoto1, Chiho Sumi-Ichinose1, Hiroshi Ichinose2,
Kazunao Kondo1
1

Dept. Pharmacol., Sch. Med., Fujita Health Univ., 2Sch. Life Sci. Tech., Tokyo Tech.

Copyright © The Japanese Pharmacological Society3-O-F4-2 Oral Sessions
Human aortic valve interstitial cells obtained from patients with calcified
aortic valve stenosis are VEGFR2 positive and contribute to ectopic
calcification
Zaiqiang Yu1, Xu Liu1, Kazuyuki Daitoku1, Ikuo Fukuda1, Shigeru Motomura2,
Tadaatsu Imaizumi3, Ken-Ichi Furukawa4, Tomoh Matsumiya3, Kazuhiko Seya3
1

Dept. Thorac. Cardiovasc. Surg., 2Dept. Pharmacol., 3Dept. Vascul. Biol., 4Dept. Orthop. Surg.

Copyright © The Japanese Pharmacological Society3-O-F4-3 Oral Sessions
Anti-Cancer Agent Oxaliplatin Caused Erectile Dysfunction in Rats throughBoth Neural and Endothelial Dysfunction
Tomoya Kataoka1, Jun Suzuki2, Yuto Kawaki2, Yohei Kito2, Yuji Hotta2, Yoshihiro Kawade2,
Yasuhiro Maeda3, Kazunori Kimura1,2
1

Department of Clinical Pharmaceutics, Graduate School of Medical Sciences, Nagoya City University,
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3Center
for Joint Research Facilities Support, Fujita Health University
2

Copyright © The Japanese Pharmacological Society3-O-F4-4 Oral Sessions
Establishment of a novel experimental autoimmune vasculitis model
Takafumi Seo1, Shota Tanaka1, Makiko Maeda2, Masanori Obana1, Yasushi Fujio1
1

Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., 2Laboratory of ClinicalPharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ.

Copyright © The Japanese Pharmacological Society3-O-F5-1 Oral Sessions
Recombinant soluble thrombomodulin reduces lipopolysaccharide-induced
endothelial cellular stiffening
Takayuki Okamoto1, Haruki Usuda1, Tetsuya Tanaka1,2, Koichiro Wada1
1

Dept. Pharmacol., Fac. of Med., Shimane Univ., 2Dept. Human Nutrition, Fac., Contemporary Life Science,
Chugoku Gakuen Univ.

Copyright © The Japanese Pharmacological Society3-O-F5-2 Oral Sessions
CXCL10 is an anti-angiogenic factor downstream of p53 in cardiomyocytes.
Ryuta Igarashi1, Masashi Tomimatsu1, Makiko Maeda1,2, Syota Tanaka1, Masanori Obana1,
Yasushi Fujio1
1

Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., 2Laboratory of ClinicalPharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ.

Copyright © The Japanese Pharmacological Society3-O-F5-3 Oral Sessions
Amino acid transporter LAT1 is upregulated in tumor-associated vascularendothelial cells and plays essential roles in tumor angiogenesis bypromoting proliferation and regulating VEGF-A-dependent pro-angiogenic
mTORC1 activation.
Ryuichi Ohgaki1,2, Lili Quan1, Suguru Okuda1, Hiroki Okanishi1, Shushi Nagamori3,
Hitoshi Endou4, Yoshikatsu Kanai1,21

Dept. Bio-sys Pharm., Grad. Sch. Med., 2Integ. Front. Res. Med. Sci. Div., OTRI, Osaka Univ., 3Dept. Lab. Med.,
Jikei Univ. Sch. Med., 4J-Pharma Co.,Ltd.

Copyright © The Japanese Pharmacological Society3-O-F5-4 Oral Sessions
Tctex-1 augments parathyroid hormone receptor-mediated Gs signaling byactivating adenylyl cyclase
1,2

2

1

1,3

Masaki Saito , Ayano Chiba , Takeya Sato , Jun Sukegawa
1Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med., 2Dept. Cellular Signalling, Grad. Sch. Pharmaceut. Sci.,
Tohoku Univ., 3Dept. Hum. Health Nutr., Shokei Gakuin Univ.

Copyright © The Japanese Pharmacological Society3-O-F5-5 Oral Sessions
Global Regulation of Protein S-palmitoylation by Nitric Oxide
Naoko Adachi1, Douglas Hess2, Izumi Koganemaru1, Takehiko Ueyama1, Naoaki Saito1
1

Biosignal Res. Ctr., Kobe University, 2ITMM, Case Western Reserve University

Copyright © The Japanese Pharmacological Society3-O-G4-1 Oral Sessions
Mycobacterial protease clp as a promising anti-TB drug target
Takehiro Yamaguchi1, Yuriko Ozeki2, Sohkichi Matsumoto2, Kentaro Tokudome1,
Shinji Matsunaga1, Shuhei Tomita1
1

Phamacol., Osaka City Univ., 2Bacteriol., Niigata Univ.

Copyright © The Japanese Pharmacological Society3-O-G4-2 Oral Sessions
Clioquinol inhibits dopamine-β-hydroxylase secretion and noradrenaline
synthesis by affecting the redox status of the copper chaperone ATOX1
Masato Katsuyama1, Chihiro Yabe-Nishimura2
1

Radioisotope Ctr., Kyoto Pref. Univ. Med.,2Dept. Pharmacol., Kyoto Pref. Univ. Med.

Copyright © The Japanese Pharmacological Society3-O-G4-3 Oral Sessions
From zebrafish to human: Rhamnan sulfate improves constipation withalteration of gut microbiota.
Yasuhito Shimada1,2,3, Hiroko Nakayama3,4, Fumiyoshi Okazaki2,3,5, Liqing Zang3,4,
Masahiro Terasawa3,6, Koichi Mastuda6, Kaoru Nishiura6, Ryota Uchida6, Norihiro Nishimura3,4
1

Dept. Int Pharm., Grad. Sch. Med., Mie Univ., 2Mie Univ. Adv. Sci. Res. Cen., Bioinfo., 3Mie Univ. Zebrafish Drug
Screen. Cen., 4Grad. Sch. Reg. Innov., Mie Univ., 5Grad. Sch. Bioresource, Mie Univ., 6Konan Chemical
Manufacturing Co., Ltd

Copyright © The Japanese Pharmacological Society3-O-G4-4 Oral Sessions
Sorghum (Sorghum bicolor L.Moench) extract enhances thiazolidinedionesinduced 3T3-L1 preadipocyte differentiation but inhibits adipogenic genes
Makoto Sakurai1, Ikumi Aizu1, Yuko Oba1, Marina Tonosaki1, Mei Nagata2, Katsuyoshi Kamiie2,
Atsuko Masumi11Dept. Mol.Pharmacol. Pharm.Sci. Aomori Univ., 2Dept. Mol.Biol. Pharm.Sci. Aomori Univ.

Copyright © The Japanese Pharmacological Society3-O-G5-1 Oral Sessions
Mitotic ER exit site disassembly and reassembly are regulated by thephosphorylation status of TANGO1
Maeda Miharu, Yukie Komatsu, Kota Saito
Dept. Biol. Inform. and Exp. Therap., Grad Sch. of Med., Akita Univ

Copyright © The Japanese Pharmacological Society3-O-G5-2 Oral Sessions
Axonal targeting of TrkA-APP complex via transcytosis
Naoya Yamashita, Takashi Sakurai
Dept. of Cell and Mol Pharmacol., Juntendo Univ., Sch. Med.

Copyright © The Japanese Pharmacological Society3-O-G5-3 Oral Sessions
Ubiquitin ligase RNF183 promotes the lysosomal degradation of NKCC1
under hypertonic conditions
Masayuki Kaneko1,2, Takumi Okamoto1,2, Kazunori Imaizumi2
1Dept. Pharmacol. Therap. Innov., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2Dept. Biochem., Grad. Sch. Biomed. &Hlth. Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society3-O-G5-4 Oral Sessions
Probiotic ferrichrome exhibited the anti-tumor effect mediating theendoplasmic stress pathway in colorectal cancer cells
Hiroaki Konishi1, Takuya Iwama2, Hiroki Tanaka3, Shotaro Isozaki2, Chikage Yamamura2,
Satoshi Ichikawa5, Kentaro Moriichi2,4, Mikihiro Fujiya1,2,4
1

Dept. Gastroenterol & Adv Med Sci, Asahikawa Med Univ, 2Dept. Med, Asahikawa Med Univ, 3Dept. Pathol,
Asahikawa Med Univ, 4Joint Res Dept. Telemed & Telecare, Asahikawa Med Univ,5Cent. Res. & Educ. Drug
Discov, Fac. Pharmaceut. Sci, Hokkaido University

Copyright © The Japanese Pharmacological Society3-O-G5-5 Oral Sessions
SIRT1, a histone deacetylase, mediates the proper DNA damage response
via histone H2AX deacetylation in the cardiomyocyte.
Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio
Dept. Pharmacol., Sapporo Med. Univ. Sch. of Med.

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