2-O-B1-1 Oral Sessions
Identification and characterization of a novel G-quadruplexes binding
protein DNAPTP6 in mouse brain
Moe Kawasaki1,2, Sefan Asamitsu1, Yasushi Yabuki1,2, Norifumi Shioda1,2
1

Dept. genomic neurology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Japan,
Graduate Schhol of Pharmaceutical Science, Kumamoto University, Japan

2

Copyright © The Japanese Pharmacological Society2-O-B1-2 Oral Sessions
GCG repeat expansion in ARX gene inhibits ARX protein translation throughthe ectopic formation of RNA G-quadruplex
Kosuke Kawakubo1,2, Sefan Asamitu1, Yasushi Yabuki1,2, Norifumi Shioda1,2
1

Department of Genomic Neurology, Institute of Molecular Embryology and Genetics(IMEG), Kumamoto
University, Japan, 2Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan

Copyright © The Japanese Pharmacological Society2-O-B1-3 Oral Sessions
C9-ALS/FTD-linked proline–arginine dipeptide repeat protein inhibits
adenosine deaminase acting on RNA
Hiroaki Suzuki, Masaaki Matsuoka
Dept. Pharmacol., Sch. of Med., Tokyo Medical Univ.

Copyright © The Japanese Pharmacological Society2-O-B1-4 Oral Sessions
Possible neuroprotective effect of lowered intracellular potassium levelNobuyuki Kuramoto, Ryosuke Hayashi, Toshihiko Kinjo, Kyosuke Uno
Lab. of Mol. Pharmacol., Fac. of Pharm. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society2-O-B2-1 Oral Sessions
Motor dysfunction and neurodegeneration are triggered by the impairmentof chaperone-mediated autophagy in cerebellar neurons.
Takahiro Seki1,2, Masahiro Sato1, Tomoko Ohta1, Yuri Morikawa2, Ayumu Konno3, Hirokazu Hirai3,
Yuki Kurauchi1,2, Hiroshi Katsuki1,21Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci, Kumamoto Univ, 2Dept Chemico-Pharmacol Sci, Sch Pharm,
Kumamoto Univ, 3Dept Neurphysiol Neural Rep, Gunma Univ Grad Sch Med

Copyright © The Japanese Pharmacological Society2-O-B2-2 Oral Sessions
Characterization of β-sheet ligand positive astrocytosis found in
Frontotemporal lobar degeneration TDP-43 type-A
Yokoyama Yuka1, Ryuichi Harada1,2, Akihiro Ohira1, Yiqing Du1, Takahiro Morito1,
Yukitsuka Kudo2, Nobuyuki Okamura3, Hiroyuki Arai2, Kazuhiko Yanai1
1

Department of Pharmacology, Tohoku University Graduate School of Medicine, 2Department of Geriatrics andGerontology, Institute of Development, Aging and Cancer, Tohoku University,3Divison of Pharmacology, Tohoku
Medical and Pharmaceutical University

Copyright © The Japanese Pharmacological Society2-O-B2-3 Oral Sessions
Caveolae formation is critical for fatty acid-binding protein 3-dependent
uptake of α-synuclein in dopaminergic neurons
Ichiro Kawahata, Tomoki Sekimori, Haoyang Wang, Kohji Fukunaga
Dept. Pharm., Grad. Sch. Pharm. Sci., Tohoku Univ.

Copyright © The Japanese Pharmacological Society2-O-B2-4 Oral Sessions
RNA G-quadruplexes accelerate liquid-to-solid transition of α-synuclein.
Yasushi Yabuki1, Kohei Maeda1, Tomohiro Mizobata2, Yasushi Kawata2, Sefan Asamitsu1,
Norifumi Shioda1
1

Dept. Geno. Neurol., IMEG., Kumamoto Univ., 2Dept. Chem. & Biotech., Grad. Sch. Eng., Tottori Univ.

Copyright © The Japanese Pharmacological Society2-O-B3-1 Oral Sessions
Disruption of glymphatic system and slow in waste clearance in the SOD1G93A mouse model of ALS
Hirose Mikako1, Mito Asano1, Saori Matsumoto1, Koji Yamanaka2, Yoichiro Abe3, Masato Yasui3,
Eiichi Tokuda4, Yoshiaki Furukawa5, Hidemi Misawa1
1

Div Pharmacol, Fac Pharm, Keio Univ, 2Dept Neurosci & Pathobiol, RIEM, Nagoya Univ, 3Div Pharmacol, Fac
Med, Keio Univ, 4Fac Pharm, Nihon Univ, 5Div Chem, Fac Sci Tech, Keio Univ

Copyright © The Japanese Pharmacological Society2-O-B3-2 Oral Sessions
Suppression of ALS-related TDP-43 aggregation by VCP inhibitor
Nakagawa Tadashi1,2, Yujiao Yu2, Toru Hosoi1, Keiko Nakayama2
1

Dept. of Clin. Pharmacol., Fac. of Pharmaceut. Sci., Sanyo-Onoda City Univ., 2Div. of Cell Prolif., Grad. Sch. ofMed., Tohoku Univ.

Copyright © The Japanese Pharmacological Society2-O-B3-3 Oral Sessions
The effect of σ1R agonist/wildtype σ1R on abnormal insoluble feature andtoxicity of σ1R ALS mutant (E102Q)
Yasuharu Shinoda, Yudai Haga, Koichiro Akagawa, Kohji Fukunaga
Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Tohoku Univ.

Copyright © The Japanese Pharmacological Society2-O-B3-4 Oral Sessions
Alpha-7 nicotinic acetylcholine receptor physically interacts with sigma-1
receptor
Yoki Nakamura1, Masatoshi Takemura2, Keisuke Ikeda2, Kazue Hisaoka-Nakashima1,
Norimitsu Morioka1
1

Dept. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., 2Sch. Pharmaceu. Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society2-O-B3-5 Oral Sessions
Recovery from spinal cord injury via M2 microglial polarization induced by
Polygalae Radix
Tomoharu Kuboyama1, Seiya Kominato2, Misaki Nagumo2, Chihiro Tohda2
1

Lab of Pharmacognosy, Daiichi Univ of Pharmacy, 2Sec of Neuromedical Science, Inst of Natural Med, Univ ofToyamaCopyright © The Japanese Pharmacological Society2-O-C1-1 Oral Sessions
Transcriptome analysis of bleomycin-induced pulmonary fibrosis intransgenic mice with modifying p38 signal in the lungs: exploration of thenovel therapeutic targets for idiopathic pulmonary fibrosis
Matsuda Shuichi1,2, Jundal Kim3, Fumihiro Sugiyama4, Yuji Matsuo2, Junji Ishida3,
Kazuya Murata3,4, Kanako Nakamura5, Kana Namiki6, Tatsuhiko Sudo7, Tomoyuki Kuwaki8,
Masahiko Hatano1, Koichiro Tatsumi2, Akiyoshi Fukamizu3, Yoshitoshi Kasuya1,61

Dept. Biomed. Sci., Grad. Sch. Med., Chiba Univ., 2Dept. Respirology, Grad. Sch. Med., Chiba Univ., 3Life Sci. Ctr.
for Survival Dynamics, Tsukuba Adv. Res. Alliance, Tsukuba Univ.,4Lab. Anim. Resour. Ctr. & Trans-Border Med.
Res. Ctr., Tsukuba Univ.,5Grad. Sch. Sci. & Tech., Tsukuba Univ.,6Dept. Biochem. & Mol. Pharmacol., Grad. Sch.
Med., Chiba Univ., 7Chem. Biol. Core Facility & Antibiotics Lab., RIKEN Adv. Sci. Inst., 8Dept. Physiol., Grad. Sch.
Med. & Dent. Sci., Kagoshima Univ

Copyright © The Japanese Pharmacological Society2-O-C1-2 Oral Sessions
The role of Myeloid-derived suppressor cells (MDSCs) in the pathogenesis of
bleomycin-induced pulmonary fibrosis.
Kotaro Kurakane1, Rika Suzuki1, Yuta Kondo1, Yuri Kozakai1, Ichiro Horie2, Yoichiro Isohama1
1

Lab.appl. Pharmacol., Fac. of Pharm. Sci.,Tokyo Univ. of Sci, 2Fac. of Pharm., Sanyo-Onoda City University

Copyright © The Japanese Pharmacological Society2-O-C1-3 Oral Sessions
The role of vascular endothelial growth factor receptor 1 tyrosine
kinase signaling in bleomycin-induced pulmonary fibrosis
Hideki Amano1, Yoshio Mastui2, Yoshiya Ito1, Koji Eshima3, Ko Hatanaka1, Kanako Hosono1,
Masabumi Shibuya4, Masataka Majima1,5
1

Department of Pharmacology Kitasato University School of Medicine, 2Department of Thoracic Surgery Kitasato
University School pf Medicine, 3Department of Immunology Kitasato University School pf Medicine, 4Gakubunkan
Institute of Physiology and Medicine Jobu University, 5Department of Medical Therapeutics Kanagawa Institute ofTechnology

Copyright © The Japanese Pharmacological Society2-O-C1-4 Oral Sessions
Evaluation of the pathological effects of ozone exposure on a mouse modelof allergic asthma and acute respiratory distress syndrome
Kengo Tomita1, Toa Okawara2, Takashi Kurihara1, Yuji Tsuji3, Tomoki Fukuyama2
1

Medical Enviroment Engineeing Group, Center for Environmental Engineering, Institute of Technology, Shimizu
Corporation, 2Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University,
3
Mechanical/Electrical Design Department, Design Division, Shimizu Corporation

Copyright © The Japanese Pharmacological Society2-O-C2-1 Oral Sessions
Effect of a LAT1-inhibitor on T cell-mediated allergic inflammation
Osamu Kaminuma1,2,3, Mayumi Saeki2, Tomoe Nishimura2, Takachika Hiroi2, Kento Miura1,
Norimasa Yamasaki1, Sawako Ogata1, Daiki Ito1, Teidai Koyama1, Akio Mori3, Hitoshi Endo4,
Naohiko Anzai5,6, Keitaro Hayashi61

Hiroshima Univ., 2Tokyo Metropol. Inst. Med. Sci., 3Sagamihara Natl. Hosp., 4J-Pharma Co. Ltd., 5Chiba Univ.,
Dokkyo Med. Univ. Sch. Med.

6

Copyright © The Japanese Pharmacological Society2-O-C2-2 Oral Sessions
Verification of prognostic factors related to pulmonary hypertension
combined with Systemic Scleroderma
Yasuhiro Kanatani1, Yoko Sato2, Hiroyuki Kobayashi11Tokai Univ. Sch. Med. Clin. Pharmacol., 2Shizuoka Gen Hosp. Res. Sup. Ctr. Stat.

Copyright © The Japanese Pharmacological Society2-O-C2-3 Oral Sessions
Inhibition of excessive cell proliferation by Rho kinase 2 (ROCK2) in
idiopathic pulmonary arterial hypertension
Aya Yamamura, Nayeem Md Junayed, Rie Takahashi, Motohiko Sato
Dept. Physiol., Aichi Medical Univ.

Copyright © The Japanese Pharmacological Society2-O-C2-4 Oral Sessions
Role of TNF-α in capillary degeneration following NMDA-induced
neurotoxicity in the neonatal rat retina
Daiki Asano1, Akane Morita1, Asami Mori2, Kenji Sakamoto2, Toshihide Kashihara1,
Tsutomu Nakahara1
1Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2Lab. Med. Pharmacol., Fac Pharma-Sci. Teikyo Univ.

Copyright © The Japanese Pharmacological Society2-O-C3-1 Oral Sessions
Quencher based chemical tag technology using exchangeable probes forlive-cell super-resolution imaging
Daisuke Asanuma1,2, Shigeyuki Namiki1, Kenzo Hirose1
1

Dept. Pharmacol., Grad. Sch. Med., The Univ. of Tokyo, 2JST PRESTO

Copyright © The Japanese Pharmacological Society2-O-C3-2

Oral Sessions
2+

In vivo imaging analysis of Ca signaling in pancreatic β-cells with2+
transgenic mice expressing ratiometric Ca indicator
Kazunori Kanemaru1, Isamu Taiko1,2, Masamitsu Iino1
1

Div. Cel. Mol. Pharm., Nihon Univ. Sch. Med., 2Dept. Physiol., Nihon Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society2-O-C3-3 Oral Sessions
Whole-organ analysis of the tumor microenvironment by tissue clearing
Shimpei Kubota1, Kei Takahashi1, Tomoyuki Mano2, Katsuhiko Matsumoto3,
Takahiro Katsumata2, Shoi Shi2, Kazuki Tainaka4, Hiroki Ueda2,3, Shogo Ehata1, Kohei Miyazono1
1

Dept. Mol. Pathol., Univ. Tokyo, 2Dept. Sys. Pharm., Univ. Tokyo, 3RIKEN BDR, 4Brain Research Institute, Niigata
University

Copyright © The Japanese Pharmacological Society2-O-C3-4 Oral Sessions
Clustering of theraputic drugs using a public database for adverse events
Ryutaro Shinkawa, Yuhei NishimuraDept. Integrative Pharm., Mie Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society2-O-C3-5 Oral Sessions
Highly efficient production of recombinant monoclonal antibodies fromgenome-edited transgenic chicken bioreactor
Takehiro Mukae, Kyoko Yoshii, Isao Oishi
Biomedical Research Institute, AIST

Copyright © The Japanese Pharmacological Society2-O-D1-1 Oral Sessions
Establishment of a culture method of the feline mammary tumor organoid
Matsui Riho, Tatsuya Usui
Lab. Veterinary Pharamcology, Tokyo University of Agriculture and Technology

Copyright © The Japanese Pharmacological Society2-O-D1-2 Oral Sessions
Effects of prolyl hydroxylase inhibitors on tumor blood vessels in tumor
mouse model.
Shinji Matsunaga1, Kazuyuki Yamaguchi1,2, Kentaro Tokudome1, Takehiro Yamaguchi1,
Shuhei Tomita1
1

Dept. Pharmacol., Grad. Sch. Med., Osaka City Univ., 2Dept. Uro., Grad. Sch. Med., Osaka City Univ.

Copyright © The Japanese Pharmacological Society2-O-D1-3

Oral Sessions
V600E

Differentiation-inducing factor-1 attenuated cellular motility of BRAF
mutation bearing malignant melanoma cells via altering mesenchymalfeatures
Masaki Arioka, Shiori Taura, Fumi Tetsuo, Momoko Kubo, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. Kyushu Univ.

Copyright © The Japanese Pharmacological Society2-O-D1-4 Oral Sessions
Development of a monoclonal antibody for CD44-expressing oral cancers
Junko Takei1,2, Mika K. Kaneko1, Tomokazu Ohishi3, Teizo Asano1, Manabu Kawada3,
Hiroyuki Harada2, Yukinari Kato1,4
1

Dept. Antibody Drug Development, Tohoku University Grad. Sch. of Med., 2Dept. Oral & Maxillofacial Surg.,
Tokyo Med. & Den. Univ., 3Inst. of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Res.
Foundation, 4New Industry Creation Hatchery Ctr., Tohoku Univ.

Copyright © The Japanese Pharmacological Society2-O-D2-1 Oral Sessions
CDK8 maintains stemness and tumorigenicity of glioma stem cells bycontrolling the c-MYC pathway
Kazuya Fukasawa, Kazuya Tokumura, Sayuki Iwahashi, Takashi Iezaki, Eiichi Hinoi
Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceutical Univ.

Copyright © The Japanese Pharmacological Society2-O-D2-2 Oral Sessions
Biological significance of CYLD expression in malignant characteristics ofglioblastoma multiforme.
Yuki Ito1, Michiko Yamaoka1, Yuki Shirakawa1, Takuichiro Hide2, Hideyuki Saito1,3,
Hirofumi Jono1,3
1

Pharm., 2Neurosurg., 3Pharm.

Copyright © The Japanese Pharmacological Society2-O-D2-3 Oral Sessions
Angiotensin II promotes tumor growth and metastatic lesion formation ofmurine TNBC 4T1 cells through the fibroblasts around cancer cells
Tomohiro Takiguchi1,2, Fumi Takahashi2, Shin Ishikane2, Toshiyuki Sasaguri1
1Dept. Clin. Pharmacol., Fac. Med. Sci., Kyushu Univ., 2Dept. Pharmacol., Sch. Med., Univ. Occup. & Environ.
Health, Japan

Copyright © The Japanese Pharmacological Society2-O-D2-4 Oral Sessions
Aberrant (pro)renin receptor expression induces genomic instability inpancreatic ductal adenocarcinoma through upregulation of
SMARCA5/SNF2H
Akira Nishiyama, Yuki Shibayama
Department of Pharmacology, Kagawa University Medical School

Copyright © The Japanese Pharmacological Society2-O-D3-1 Oral Sessions
Identification of a candidate drug for the prevention of cisplatin-induced
nephrotoxicity by a database analysis-basic research-clinical study
Yasumasa Ikeda1, Hirofumi Hamano2, Mitsuhiro Goda2, Keijo Fukushima3, Seiji Kishi4,
Masayuki Chuma5, Yoshito Zamami6, Licht Miyamoto7, Keisuke Ishizawa6, Hiromichi Fujino3,
Ken-ichi Aihara8, Koichiro Tsuchiya7, Toshiaki Tamaki9
1

Dept. Pharmacol. Tokushima Univ., 2Dept. Pharm. Tokushima Univ. Hosp., 3Dept. Pharmacol. Life Sci., 4Dept.
General Med. Kawasaki Med. Hosp., 5Clin. Trial Ctr. Tokushima Univ. Hosp.,6Dept. Clin. Pharmacol. Tokushima
Univ., 7Dept. Med. Pharmacol. Tokushima Univ., 8Dept. Comm. Med. and Med. Sci., 9Anan Med. Ctr.

Copyright © The Japanese Pharmacological Society2-O-D3-2 Oral Sessions
Streptolysin O: a novel mediator of endothelial dysfunction
Masashi Mukohda1, Mihiro Seki1, Sho Nakamura2, Kosuke Takeya3, Akira Takanori4,
Takanori Yano5, Risuke Mizuno1, Hiroshi Ozaki1
1

Lab. of Vet. Pharm., Faculty of Vet. Med., Okayama Univ. of Science,2Lab. of Animal Health, Faculty of Vet. Med.,Okayama Univ. of Science, 3Lab. of Biochem., Faculty of Vet. Med., Okayama Univ. of Science, 4Lab. of Vet InternalMed, Faculty of Vet. Med., Okayama Univ. of Science, 5Dept. of biochem., Faculty of Science, Okayama Univ. of
Science

Copyright © The Japanese Pharmacological Society2-O-D3-3 Oral Sessions
Effects of molidustat, a HIF-PHD inhibitor, on sodium dynamics anddistribution in hypertensive subtotally nephrectomized rats
Anqi Zhang, Daisuke Nakano, Norihiko Morisawa, Akira Nishiyama
Dept. Pharmacol., Kagawa Univ.

Copyright © The Japanese Pharmacological Society2-O-D3-4 Oral Sessions
Dexamethasone induces sodium and water loss in skin
Kento Kitada1, Norihiko Morisawa2, Daisuke Nakano1, Jens Titze3, Akira Nishiyama1
1

Department of Pharmacology, Faculty of Medicine, Kagawa University, 2Division of Nephrology andHypertension, Department of Internal Medicine, Jikei University School of Medicine, 3Cardiovascular andMetabolic Disorders, Duke-NUS Medical School

Copyright © The Japanese Pharmacological Society2-O-D3-5 Oral Sessions
Development of a novel treatment for interstitial cystitis using filteredadipose-derived stem cells lysate
Maaya Shibayama1, Yuji Hotta1, Kotomi Maeda1, Seiji Matsumoto2, Tomoya Kataoka3,
Tokunori Yamamoto4, Kazunori Kimura1,3
1

Dept. Hospital Pharm., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2Cent. Adv. Res. Edu., Asahikawa Med. Univ.,
3
Dept. Clinical Pharm., Grad. Sch. Med. Sci., Nagoya City Univ., 4Dept. Neph., Grad. Sch. Med. Sci., Nagoya Univ.

Copyright © The Japanese Pharmacological Society