2-O-037 Oral Sessions
Proposal of Therapeutic Strategy to Prevent the Relapse in Inflammatory
Bowel Disease
Shusaku Hayashi, Yudai Ogawa, Takeshi Yamamoto, Makoto Kadowaki
Inst. Natural Med., Univ. of Toyama

Copyright © The Japanese Pharmacological Society2-O-038 Oral Sessions
Activated iNKT cells promote liver repair by acceleration of macrophage
polarization
Yoshiya Ito1, Takuya Goto1, Masashi Satoh2, Atsushi Yamashita1, Mayuko Osada1,
Mina Tanaba1, Ko Hatanaka1, Kanako Hosono1, Hideki Amano1
1

Dept. Pharm., Sch. Med., Kitasato Univ., 2Dept. Immu, Sch. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society2-O-039 Oral Sessions
Role of prostanoids in hepatic stellate cell function
Koh-ichi Yuhki1, Tomoko Ohkubo1, Koh Nakayama1, Shuh Narumiya2, Fumitaka Ushikubi1
1

Dept. Pharmacol., Asahikawa Med. Univ., 2Dept. Drug Discovery Med., Kyoto Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society2-O-040 Oral Sessions
Role of IL-17A and IL-17F in the pathogenesis and steroid sensitivity inhouse dust mite extract-sensitized asthmatic mice
Hideaki Ohno1, Kazuhito Murakami1, Yoichiro Iwakura2, Yoichiro Isohama1
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2Center for Animal Disease Models, ResearchInstitute for Biomedical Sciences, Tokyo University of Science

Copyright © The Japanese Pharmacological Society2-O-041 Oral Sessions
Therapeutic effects of angiotensin converting enzyme 2 (ACE2) enzyme
activity on acute lung injury in COVID-19
Tomokazu Yamaguchi1, Midori Hoshizaki1,2, Takafumi Minato1, Satoru Nirasawa3,
Masamitsu Asaka4, Mayumi Niiyama5, Jianbo An1, Daichi Utsumi4, Satoshi Nagata6,
Haruhiko Kamada5, Wataru Kamitani7, Yoshihiro Kawaoka8, Yasuhiro Yasutomi4, Yumiko Imai2,
Keiji Kuba1
1

Department of Biochemistry and Metabolic Science, Akita University, 2Laboratory of Regulation of Intractable
Infectious Diseases, NIBIOHN, 3Biological Resources and Post-Harvest Division, Japan International ResearchCenter for Agricultural Sciences, 4Tsukuba Primate Research Center, NIBIOHN,5Laboratory of Biopharmaceutical
Research, NIBIOHN, 6Laboratory of Antibody Design, NIBIOHN, 7Department of Infectious Diseases and Host
Defense, Graduate School of Medicine, Gunma University, 8Division of Virology, Department of Microbiology and
Immunology, Institute of Medical Science, University of Tokyo

Copyright © The Japanese Pharmacological Society2-O-042 Oral Sessions
ERK5 regulates stemness and tumorigenicity of glioma stem cells bycontrolling the STAT3 signaling
Akane Suzuki, Kazuya Fukasawa, Tetsuhiro Horie, Misato Murata, Masaki Kobayashi,
Eiichi Hinoi
Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society2-O-043 Oral Sessions
Novel roles of ribosomal protein S6 promotes in development andmaintenance of glioblastoma multiforme stem cells
Hirofumi Jono1,3, Yuki Shirakawa2, Yuki Ito3, Shunsuke Miyake1,3, Ayumi Kanemaru3,
Takuichiro Hide4, Akitake Mukasa5, Kunimasa Ohta6, Hideyuki Saito1,3
1

Kumamoto Univ. Hosp., 2Juntendo Univ., 3Grad. Sch. of Pharmaceut. Sci., Kumamoto Univ., 4Kitasato Univ. Sch. ofMed., 5Grad. Sch. of Med. Sci., Kumamoto Univ., 6Fac. of Arts and Sci., Kyushu Univ.

Copyright © The Japanese Pharmacological Society2-O-044 Oral Sessions
Angiotensin II promotes primary tumor growth and metastasis formation ofmurine TNBC 4T1 cells through the fibroblasts around cancer cells
Tomohiro Takiguchi1,2, Fumi Takahashi2, Shin Ishikane2, Toshiyuki Sasaguri1
1Dept. Clin. Pharmacol., Fac. Med. Sci., Kyushu Univ., 2Dept. Pharmacol., Sch. Med., Univ. Occup. & Environ.
Health, Japan

Copyright © The Japanese Pharmacological Society2-O-045 Oral Sessions
Spatial transcriptome analysis revealed novel regulatory mechanism oftumor metastasis
Jianbo An1, Yushi Nagaki2, Midori Hoshizaki1,3, Tomokazu Yamaguchi1, Yuta Kuze4,
Yumiko Imai3, Satoru Motoyama2, Yutaka Suzuki4, Keiji Kuba1
1

Dept. of Biochemistry and Metabolic Science., Akita Univ. Grad. Sch. of Med., 2Dept. of Comprehensive Cancer
Control, Akita Univ. Grad. Sch. of Med., 3Natl. Inst. of Biomedical Innovation, Health and Nutrition, 4Lab. ofSystems Genomics, Dept. of Computational Biology and Medical Sciences, Grad. Sch. of Frontier Sciences., The
Univ. of Tokyo

Copyright © The Japanese Pharmacological Society2-O-046 Oral Sessions
Integrin β5 inhibitor can suppress gastric cancer cell invasiveness throughIntegrinβ5-FARP1-CDC42 cascade
Tatsuhiko Furukawa1, Kentaro Minami2, Kouich Kawahara1, Matatatsu Yamamoto1
1

Kagoshima Univ. Gad. Sch. Med. Dent. Sci. Molec. Oncol., 2Miyazaki Med. Coll. Hosp. Dept. Pharm.

Copyright © The Japanese Pharmacological Society2-O-047 Oral Sessions
Inhibitory effects of Kamebakaurin from Rabdosia excisa on FcεRIaggregated mast cells activation
Haruka Asai1, Mayu Miyasaka1, Kaho Hatsukawa1, Nanami Murakami1, Naoko Takeda1, MingYu Gui2, Yong-Ri Jin2, Xu-Wen Lib2, Koichi Takeya3, Yukio Hitotsuyanagi3, Yutaka Aoyagi1,
Nobuyuki Fukuishi1
1Coll. of Pharm., Kinjo Gakuin Univ., 2Dept. of Chem., JiLin Univ., 3Sch. of Pharm., Tokyo Univ. of Pharm. and Life
Sci.

Copyright © The Japanese Pharmacological Society2-O-048 Oral Sessions
Phenotype changes in group 2 innate lymphoid cells (ILC2) in a murine
model of intractable asthma
Yoshiyuki Tanaka, Masaya Matsuda, Chihiro Watanabe, Riku Murata, Hayato Shimora,
Kennosuke Hashimoto, Ryohei Chinai, Kazuyuki Kitatani, Takeshi Nabe
Immunopharmacol.

Copyright © The Japanese Pharmacological Society2-O-049 Oral Sessions
Low concentration of ozone exposure exacerbates lung injury and allergic
asthma in a mouse model
Kengo Tomita1, Chiharu Oohira2, Toa Ookawara2, Takashi Kurihara1, Tomoki Fukuyama2
11) Medical Environment Engineering Group, Center for Environmental Engineering, Institute of Technology,
Shimizu Corporation, 22) Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University

Copyright © The Japanese Pharmacological Society2-O-050 Oral Sessions
Analysis of the balance between oral immune tolerance for food andpercutaneous loading of food allergen in the development of food allergy
using murine models
Hirotaka Yamashita1, Hiroyuki Tanaka2,3, Naoki Inagaki4, Masato Tsutsui1
1

Dept. Pharmacol. Ryukyu Univ., 2Lab. Immunobiol. Gifu Pharm. Univ., 3Uni. Grad. Sch. Drug Discov. Med. Info.
Sci., Gifu Univ., 4Dept. Pharm. Gifu Univ. Med. Sci.

Copyright © The Japanese Pharmacological Society2-O-051 Oral Sessions
NKG2D-high T cells are able to be activated regardless of the level of NKG2D
ligands expression
Hitoshi Toyoda1,2,3,4, Masahiro Hosonuma1,2,3,8, Atsuo Kuramasu1, Youichirou Narikawa1,2,3,5,
Masakazu Murayama1,2,3,5, Junya Isobe6, Midori Shida1, Takehiko Sambe7, Mayumi Tsuji3,
Takuya Tsunoda8, Shinichi Kobayashi9, Katsunori Inagaki4, Yuji Kiuchi2,3, Kiyoshi Yoshimura1,2,3,8
1

Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology andTherapeutics, Showa University, Tokyo, Japan., 2Department of Pharmacology, Showa University School of
Medicine, Tokyo, Japan., 3Pharmacological Research Center, Showa University, Tokyo, Japan.,4Department ofOrthopaedic Surgery, School of Medicine, Showa University School of Medicine, Tokyo, Japan., 5Department of
Otodhinolaryngology-Head and Neck, School of Medicine, Showa University School of Medicine, Tokyo, Japan.,6
Department of Hospital Pharmaceutics, School of Pharmacy, Showa University, Tokyo, Japan., 7Division ofClinical Pharmacology, Department of Pharmacology, Showa University School of Medicine., 8Division of Medical
Oncology, Department of Medicine, Showa University School of Medicine, Showa University School of Medicine,Tokyo, Japan., 9Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University Tokyo,
Japan.

Copyright © The Japanese Pharmacological Society2-O-052 Oral Sessions
Immunological effects of inosine, a metabolite from gut microbiota, in thetumor microenvironment
Yoichiro Narikawa1,2,3,4, Masahiro Hosonuma1,2,3,5, Atsuo Kuramasu1, Sei Kobayashi6,
Masakazu Murayama1,2,3,4, Hitoshi Toyoda1,2,3,7, Jyunya Isobe8, Midori Shida1, Takehiko Sambe9,
Mayumi Tsuji3, Takuya Tsunoda5, Shinichi Kobayashi10, Toshikazu Shimane11,
Hitome Kobayashi4, Yuji Kiuchi2,3, Kiyoshi Yoshimura1,51

Dept. of Clin. Immuno Oncology, Clin. Res. Inst. for Clin. Pharmacol. and Therap., Showa Univ., Tokyo, Japan.,
Dept. of Pharmacol., Showa Univ. Sch. of Med., Tokyo, Japan., 3Pharmacol. Res. Ctr., Showa Univ., Tokyo, Japan.,4
Dept. of Otorhinolaryngology - Head and Neck Surg., Showa Univ. Sch. of Med., Tokyo, Japan.,5Div. of Med.
Oncology, Dept of Med., Showa Univ. Sch. of Med., Tokyo, Japan.,6Dept. of Otorhinolaryngology, Fujigaoka
Hosp., Yokohama, Kanagawa, Japan., 7Dept. of Orthopaedic Surg., Showa Univ. Sch. of Med., Tokyo, Japan., 8Dept.
of Hosp. Pharmaceut., Sch. of Pharm., Showa Univ., Tokyo, Japan., 9Div. of Clin. Pharmacol., Dept. of Pharmacol.,Showa Univ. Sch. of Med, Tokyo, Japan., 10Clin. Res. Inst. for Clin. Pharmacol. and Therap., Showa Univ., Tokyo,
Japan., 11Head and Neck Oncology Ctr., Showa Univ., Tokyo, Japan.
2

Copyright © The Japanese Pharmacological Society2-O-053 Oral Sessions
Immunological Modification of the Head and Neck Cancer Microenvironment
by Short Chain Fatty Acids
Murayama Masakazu1,2,3,4, Masahiro Hosonuma1,2,3,9, Atsuo Kuramasu1, Sei Kobayshi5,
Youichirou Narikawa1,2,3,4, Hitoshi Toyoda1,2,3,6, Junya Isobe7, Midori Shida1, Takehiko Sambe8,
Mayumi Tsuji3, Takuya Tsunoda9, Shinichi Kobayashi10, Toshikazu Shimane11,
Hitome Kobayashi4, Yuji Kiuchi2,3, Kiyoshi Yoshimura1,9
1

Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology andTherapeutics, Showa University, Tokyo, Japan., 2Department of Pharmacology, Showa University School of
Medicine, Tokyo, Japan., 3Pharmacological Research Center, Showa University, Tokyo, Japan.,4Department ofOtorhinolaryngology-Head and Neck Surgery, Showa University School of Medicine, Tokyo, Japan., 5Department ofOtorhinolaryngology, Fujigaoka hospital, Yokohama, Kanagawa, Japan., 6Department of Orthopaedic Surgery,
School of Medicine, Showa University., 7Department of Hospital Pharmaceutics, School of Pharmacy, Showa
University, Tokyo, Japan., 8Division of Clinical Pharmacology, Department of Pharmacology, Showa University
School of Medicine., 9Division of Medical Oncology, Department of Medicine, Showa University School of
Medicine, Tokyo, Japan., 10Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa
University, Tokyo, Japan., 11Head and Neck Oncology Center, Showa University, Tokyo, Japan.

Copyright © The Japanese Pharmacological Society2-O-054 Oral Sessions
Effect of hypoxia-inducible factors in tumor infiltrating macrophage on
tumor growth
Shinji Matsunaga, Kazuyuki Yamaguchi, Ryo Hirakawa, Kentaro Tokudome,
Takehiro Yamaguchi, Shuhei Tomita
Dept. Pharmacol. Osaka City Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society2-O-055 Oral Sessions
A novel anti-TROP2 monoclonal antibody TrMab-6 possesses antitumor
activity in breast cancer models
Tomohiro Tanaka1, Hiroyuki Suzuki2, Tomokazu Ohishi3, Manabu Kawada3, Mika K.Kaneko1,
Yukinari Kato1,2
1

Dept. Antibody Drug Development, Tohoku University Grad. Sch. of Med., 2Dept. Molecular Pharmacology,
Tohoku University Grad. Sch. of Med., 3Inst. of Microbial Chemistry (BIKAKEN), Microbial Chemistry Res.
Foundation

Copyright © The Japanese Pharmacological Society2-O-056 Oral Sessions
Antitumor activity of a novel anti HER3 monoclonal antibody in mouse
xenografts of colorectal cancer
Teizo Asano1, Tomokazu Ohishi2, Hiroyuki Suzuki3, Manabu Kawada2, Mika K. Kaneko1,
Yukinari Kato1,3
1

Dept. Antibody Drug Development, Tohoku Univ. Grad. Sch. of Med., 2Inst. of Microbial Chemistry (BIKAKEN),
Numazu, Microbial Chemistry Res. Foundation, 3Dept. Molecular Pharmacology, Tohoku Univ. Grad. Sch. of Med.

Copyright © The Japanese Pharmacological Society2-O-057 Oral Sessions
Renal protective action of a traditional Japanese Kampo medicine
Yasumasa Ikeda1, Masafumi Funamoto1, Masaki Imanishi2, Koichiro Tsuchiya2
1

Tokushima Univ. Pharmacol., 2Tokushima Univ. Med. Pharmacol.

Copyright © The Japanese Pharmacological Society2-O-058 Oral Sessions
Cell growth inhibitory effect of the green tea amino acid L-theanine in cells
expressing solute carrier family 7 member 5.
Toshihiko Kinjo1, Kyosuke Uno1, Yukio Yoneda2, Sadaaki Maeda3, Nobuyuki Kuramoto1
1

Lab of Mol. Pharmacol., Fac. of Pharm. Sci., Setsunan Univ., 2Inst. of Prophylactic Pharmacol, 3Lab of
Pharmacother., Fac. of Pharm. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society2-O-059 Oral Sessions
Effect of long-term intake of sweet beverages on feeding behavior andglucose metabolism in mice.
Sato Sachiko, Yukiko Kondo, Eiichi Taira
Dept. Pharmacol., Iwate Med. Univ., Iwate, Japan

Copyright © The Japanese Pharmacological Society2-O-060 Oral Sessions
Learning outcomes of the online role-play for pharmacological education:comparison between players and audiences
Tadaho Nakamura1, Fumito Naganumra1, Nobuyuki Okamura1, Toshihiko Yanagita2
1

Div. Pharmacol., Fac. Med, Tohoku Med. Pharm. Univ,2Dept. Clin. Pharmacol., Sch. Nursing, Fac. Med., Univ.
Miyazaki

Copyright © The Japanese Pharmacological Society2-O-061 Oral Sessions
Brain injury triggers the endoplasmic reticulum stress response in various
cell types at different time periods.
Mika Takarada-Iemata, Qiyan Fan, Osamu Hori
Dept. Neuroanat. Kanazawa Univ.

Copyright © The Japanese Pharmacological Society2-O-062 Oral Sessions
Effects of sibiricose A5, a constituent of Polygalae Radix, on recovery of
memory in the mouse model of Alzheimer‘s disease
Tomoharu Kuboyama1, Yuta Arake1, Misaki Nagumo2, Seiya Kominato2, Chihiro Tohda2
1Lab. of Pharmacognosy, Daiichi Univ. of Pharmacy, 2Sec. of Neuromedical Science, Inst. of Natural Medicine,Univ. of Toyama

Copyright © The Japanese Pharmacological Society2-O-063 Oral Sessions
Dysfunction of a peripheral lipid sensor GPR120 causes PGD2-microgliaprovoked neuroinflammation and neurodegeneration in the mouse
hippocampus
Kensuke Iwasa1, Shinji Yamamoto1, Akira Hirasawa2, Kei Maruyama1, Keisuke Yoshikawa1
1

Dept. Pharmacol., Saitama Med University., 2Dep. of Genomic Drug Discovery, Faculty of Pharmaceutical
Sciences, Kyoto University

Copyright © The Japanese Pharmacological Society2-O-064 Oral Sessions
Role of microglia in reserpine-induced mechanical pain, a model offibromyalgia
Hidetoshi Saitoh1, Masako Hosoi2,3, Makoto Tsuda4
1Dept. Pharmacol., Sch. Pharm. Fukuoka, IUHW, 2Dept. Psychosomatic Med., Kyushu Univ. Hosp., 3Dept.
Psychosomatic Med., Grad. Sch. Med. Sci., Kyushu Univ., 4Dept. Mol. Sys. Pharmacol., Grad. Sch. Pharmaceut.
Sci., Kyushu Univ.

Copyright © The Japanese Pharmacological Society2-O-065 Oral Sessions
The effects of sialidase on the epidermal nerve fiber innervation during
inflammatory pain
Shun Watanabe1,2, Marie Abe1,2, Mami Sagawa1,2, Riho Fujita1,2, Motoki Morita1,2, Misa Oyama1,2,
Takashi Iwai1,2, Mitsuo Tanabe1,2
1Lab. Pharmacol., Sch. of Pharmaceut. Sci., Kitasato Univ., 2Med. Res. Lab., Lab. Pharmacol., Sch. of Pharmaceut.
Sci., Kitasato Univ.

Copyright © The Japanese Pharmacological Society2-O-066 Oral Sessions
Elucidation of the mechanism olanzapine-induced obesity – Involvement of
leptin resistance
Morimoto Riko, Karen Kuriya, Shoko Sashiyama, Nana Inoue, Tadashi Nakagawa,Yasuhiro Noda, Toru Hosoi
Dept. of Clin. Pharmacol., Fac. of Pharmaceut. Sci., Sanyo-Onoda City Univ.

Copyright © The Japanese Pharmacological Society2-O-067

Oral Sessions
2+

In vivo analysis of Ca activities in β-cells using a transgenic mouse line2+
expressing a ratiometric Ca sensor
Kazunori Kanemaru, Isamu Taiko, Masamitsu Iino
Dept. Physiol., Nihon Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society2-O-068 Oral Sessions
A novel mechanism of CaV1.2 degradation by lipotoxicity in pancreatic β-cellline MIN6.
Daisuke Ohshima, Yoshinori Mikami, Taichiro Tomida, Satomi Adachi-Akahane
Dept. of Physiol., Sch of Med., Fac. of Med., Toho Univ.

Copyright © The Japanese Pharmacological Society2-O-069 Oral Sessions
Probiotic polyphosphate improves the intestinal injury through the integrin
mediated endocytic pathway
Konishi Hiroaki1, Shotaro Isozaki2, Chikage Yamamura2, Shin Kashima2, Kentaro Moriichi2,
Mikihiro Fujiya1,21Asahikawa Med Univ. Dept. of Gastro. Adv. Med. Sci., 2Asahikawa Med Univ. Dept. of Med.

Copyright © The Japanese Pharmacological Society2-O-070 Oral Sessions
Paradoxical Src activation and cancer cell proliferation induced by tyrosine
kinase inhibitors
Naoki Watanabe1,2, Makio Higuchi1
1

Dept. of Pharmacol., Kyoto Univ. Grad. Sch. of Med., 2Single-Molecule Cell Biology, Kyoto Univ. Grad. Sch. of
Biostudies

Copyright © The Japanese Pharmacological Society2-O-071 Oral Sessions
Leupaxin is upregulated in fibrotic kidneys and contributes to theproliferation of kidney fibroblasts
Shunsuke Noda1, Masanori Obana1,3, Yoshiaki Miyake1, Ayaha Yamamoto1, Shota Tanaka1,
Makiko Maeda2, Yoshiaki Okada1, Yasushi Fujio1,3
1

Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical sciences, Osaka University,
Laboratory of Clinical Pharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ., 3Integrated Frontier
Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI),
Osaka University
2

Copyright © The Japanese Pharmacological Society2-O-072 Oral Sessions
Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small
molecule having anti-inflammatory and antioxidant activities, in a mousemodel of acute kidney injury
Keita Shibata1,2, Terumasa Hashimoto1, Keiji Hasumi3, Koji Nobe1,2
1

Dept. Pharmacol., Showa Univ., Sch. Pharmacy, 2Pharmacol. Res. Cent., Showa Univ., 3Dept. Appl. Biol. Sci.,
Tokyo Univ. of Agricul. and Technol.

Copyright © The Japanese Pharmacological Society2-O-073 Oral Sessions
Is the priapism of sepiapterin reductase-deficient mice caused by nitricoxide overproduction ?
Chiho Sumi-Ichinose1, Yui Suganuma1, Taiki Kano1, Kazuhisa Ikemoto1, Noriko Ihira1,
Hiroshi Ichinose2, Kazunao Kondo1
1

Dept. Pharmacol., Sch. Med., Fujita Health Univ., 2Sch. Life Sci. and Tech., Tokyo Inst. Tech.

Copyright © The Japanese Pharmacological Society2-O-074 Oral Sessions
Testosterone improves erectile dysfunction induced by doxorubicin in rats
by suppressing the inflammatory response in the corpus cavernosum
Tomoya Kataoka1, Akimasa Sanagawa2, Yuji Hotta2, Yoko Hibi2, Kazunori Kimura1,2
1

Department of Clinical Pharmaceutics, Graduate School of Medical Sciences, Nagoya City University,
Department of Clinical Pharmaceutics, Graduate School of Medical Sciences, Nagoya City University

2

Copyright © The Japanese Pharmacological Society2-O-075 Oral Sessions
Fibrin-mediated growth restriction of early-stage human trophoblasts is
switched to growth promotion through fibrinolysis
Takayuki Iwaki1, Yukiko Asano1,2, Hiroaki Itoh2, Kazuo Umemura1
1

HUSM, 2HUSM

Copyright © The Japanese Pharmacological Society2-O-076 Oral Sessions
Cisplatin induces gustatory nerve degeneration in taste disturbance model
rats
Kanako So, Ryotaro Matsuo, Momoka Iida, Soichiro Kano, Yui Oyabu, Masahiro Tsuda,
Fumiyoshi Yamashita
Dept. Appl. Pharmaceutics and Pharmacokinetics, Grad. Sch. Pharmaceut. Sci., Kyoto Univ.,

Copyright © The Japanese Pharmacological Society2-O-077 Oral Sessions
The regulation of BNP transcription and DNA methylation modification in
anticancer drug-induced cardiomyocyte toxicity.
Hosoda Hiroshi
NCVC Res. Inst., Dept. of Regenerative Medicine and Tissue Engineering

Copyright © The Japanese Pharmacological Society2-O-078
2+

Oral Sessions+

Ca -activated K channel inhibition overcomes resistance to antiandrogens
in a prostate cancer spheroid model
Susumu Ohya, Junko Kajikuri, Hiroaki Kito, Kyoko Endo, Miki Matsui
Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society2-O-079 Oral Sessions
Screening of protein-protein interaction inhibitors using Nano-luc system forcancer therapy
Suzuki Hiroyuki1, Mika Kaneko2, Yukinari Kato1,2
1

Dept. Molecular Pharmacology, Tohoku University Grad. Sch. of Med., 2Dept. Antibody Drug Development,
Tohoku University Grad. Sch. of Med.

Copyright © The Japanese Pharmacological Society2-O-080 Oral Sessions
Development of a novel therapeutic method for muscle-invasive bladdercancer using normal canine bladder organoids
Tatsuya Usui
Tokyo University of Agriculture and Technology

Copyright © The Japanese Pharmacological Society2-O-081 Oral Sessions
Prenatal valproic acid exposure-induces the hyper-NMDA receptor signaling
in prefrontal cortex and autism spectrum disorder-like behaviors throughhypo-signaling of 5-HT1A receptor in mice.
Hitomi Kurahashi1, Akihiro Mouri1,4, Kazuo Kunisawa1, Kenji Tanaka5, Hisayoshi Kubota1,
Masaya Hasagawa1, Aika Kosuge1, Kuniaki Saito2,3,4, Toshitaka Nabeshima3,41

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Univ., 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.,
4NPO. J-DO, 5Dept. Neuropsychiatry., School of Medicine., Keio Univ.

Copyright © The Japanese Pharmacological Society2-O-082 Oral Sessions
Shati/Nat8l deficiency impairs attention by disrupting dopaminergic
projections of the ventral tegmental area-prefrontal cortex in mice
Kazuo Kunisawa1, Bolati Wulaer2,3, Aika Kosuge1, Moeka Tanabe1, Kuniaki Saito2,3,4,
Toshitaka Nabeshima3,4, Akihiro Mouri1,41

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Univ., 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.,
4NPO, J-DO.

Copyright © The Japanese Pharmacological Society2-O-083 Oral Sessions
Pathogenic mechanism of autism caused by anti-epileptic drug valproic acid
Nakagawa Tadashi, Toru Hosoi
Dept. of Clin. Pharmacol., Fac. of Pharmaceut. Sci., Sanyo-Onoda City Univ.

Copyright © The Japanese Pharmacological Society2-O-084 Oral Sessions
Both mating and cohabitation until late pregnancy are required to induce
female experience -dependent changes of inhibitory synaptic input in the
medial preoptic area of male mice
Taiju Amano, Kazuki Ito, Masabumi Minami
Hokkaido University, Grad Sch Pharm Sci, Dept Pharmacol

Copyright © The Japanese Pharmacological Society2-O-085 Oral Sessions
An investigation of the role of primary cilia in the repairing process after
brain injury
Takashi Shiromizu1, Ryouhei Shibata1, Daishi Yamakawa2, Masaki Inagaki2, Yuhei Nishimura1
1Dept. Integrative Pharm., Grad. Sch. Med., Mie Univ., 2Dept. Physiology, Grad. Sch. Med., Mie Univ.

Copyright © The Japanese Pharmacological Society2-O-133 Oral Sessions
Adolescent binge drinking induces behavioral abnormalities through myelin
abnormalities in gray matter in adulthood
Sugawara Yumika1, Kunisawa Kazuo1, Kohei Yoshidomi1, Yuki Kon1, Kuniaki Saito2,3,4,
Akihiro Mouri1,4, Toshitaka Nabeshima3,41

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Univ., 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.,
4NPO.J-DO.

Copyright © The Japanese Pharmacological Society2-O-086 Oral Sessions
Long-term Advanced Glycation End Product 3 (AGE3) Stimulation Reduces
Aggrecan and Type II Collagen Production in Human Chondrocytes
Omer Faruk Hatipoglu1, Takashi Nishinaka1, Hidenori Wake1, Shuji Mori2, Masahiro Watanabe2,
Takao Toyomura2, Hideo Takahashi1
1

Kindai University, Department of Pharmacology, 2School of Pharmacy, Shujitsu University

Copyright © The Japanese Pharmacological Society2-O-087 Oral Sessions
Establishment of high-throughput drug screening system using human limb
bud mesenchymal cells derived from skeletal dysplasia specific iPSC
Daisuke Yamada1, Tomoka Takao1, Masahiro Nakamura2, Lu Ming1, Junya Toguchida3,
Takeshi Takarada1
1

Dept. Reg. Sci., Okayama Univ., 2Dept. Bio.Eng., The Univ. Tokyo., 3Dept. Tiss. Reg., Kyoto Univ.

Copyright © The Japanese Pharmacological Society2-O-088 Oral Sessions
Erk5 in mesenchymal stem cells maintains bone homeostasis in adulthood
Tetsuhiro Horie, Kazuya Fukasawa, Takanori Yamada, Takashi Iezaki, Eiichi Hinoi
Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society2-O-089 Oral Sessions
Therapeutic effects of CDK8 kinase inhibitor on abnormal bone developmentin achondroplasia model mice
Sayuki Iwahashi1, Takuya Kadota2, Kazuya Fukasawa1, Takashi Iezaki1, Hiroaki Shirahase2,
Tatsuya Kitao2, Eiichi Hinoi1
1Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceut. Univ., 2Drug Discovery Res. Dept., Kyoto
Pharmaceut. Ind.

Copyright © The Japanese Pharmacological Society2-O-090 Oral Sessions
Ozone water as a potential preventive and therapeutic option for periodontal
disease in dogs
Fukuyama Tomoki1, Mao Kaneki1, Chiharu Oohira1, Jumpei Uchiyama1,2, Tetsuya Ano3
1Sch. Vet. Med., Azabu Univ., 2Grad. Sch. Med. Dent. & Pharmaceut. Sci., Okayama Univ., 3Hakuto Co., Ltd.

Copyright © The Japanese Pharmacological Society2-O-091 Oral Sessions
Involvement of miRNA mediated-upregulation of Kir2.1 in mouse osteoblast
differentiation
Hiroaki Kito, Kyoko Endo, Junko Kajikuri, Susumu Ohya
Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society2-O-092 Oral Sessions
CRISPR Interference-based Screening for Prediction of Synergistic/Additive
Effects of Novel Combinations of Anti-Tuberculosis Drugs
Samukawa Noriaki1, Takehiro Yamaguchi1, Yuriko Ozeki2, Sohkichi Matsumoto2,
Kentaro Tokudome1, Shinji Matsunaga1, Shuhei Tomita1
1

Dept. Pharmacol., Osaka City Univ. Grad. Sch. Med., 2Dept. Bacteriology, Niigata Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society2-O-093 Oral Sessions
Sympathetic neuronal mechanisms in the regulation of mouse colonicmotility.
Yoshihiko Kito1, Masaaki Kurahashi21Dept. Pharmacol., Fac. Med., Saga Univ., 2Dept. Physiol., Univ. Nevada, Sch. Med.

Copyright © The Japanese Pharmacological Society2-O-094 Oral Sessions
Therapeutic effect of lactulose on intestinal flora structure and compositionin colitis-associated tumorigenesis
Lin Kurahara1, Feiyan Zhao2, Keizo Hiraishi1, Xiaodong Li1, Heping Zhang2, Katsuya Hirano1
1

Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa, Japan, 2Key
Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural
University, China

Copyright © The Japanese Pharmacological Society2-O-095 Oral Sessions
Oral microbiome in eosinophilic esophagitis
Haruki Usuda, Tomomi Niibayashi, Takayuki Okamoto, Koichiro Wada
Dept. Pharmacol., Fac. Med., Shimane Univ.

Copyright © The Japanese Pharmacological Society2-O-096 Oral Sessions
Repositioning of hypoxia-responsive genes in the nucleus under prolonged
hypoxic conditions
Koh Nakayama1, Sigal Shachar2, Elizabeth Finn2, Hiroyuki Sato3, Akihiro Hirakawa3, Tom Misteli2
1

Dept. of Pharmacol., Asahikawa Med. Univ., 2Ctr. for Cancer Research, NCI, NIH, 3Dept. of Clin. Biostat., TMDU

Copyright © The Japanese Pharmacological Society2-O-097 Oral Sessions
Formation of sulfur metabolites by plasma irradiation and their physiologicalsignificanceAkiyuki Nishimura1, Tomohiro Tanaka1, Kakeru Shimoda1, Shota Sasaki2, Toshiro Kaneko2,
Motohiro Nishida1,3
1Div. Cardiocirc. Signal., NIPS, 2Sch. of Eng., Tohoku Univ., 3Grad. Sch. Pharmaceut. Sci., Kyushu Univ.

Copyright © The Japanese Pharmacological Society2-O-098 Oral Sessions
YAP promotes cardiomyocyte glycolysis through a YAP-TEAD1-HIF-1αdependent mechanism
Toshihide Kashihara1, Tsutomu Nakahara1, Junichi Sadoshima2
1

Dept. of Mol. Pharmacol., Sch. of Pharmaceut. Sci., Kitasato Univ., 2Rutgers New Jersey Med. Sch. Cardiovasc.
Res. Inst. Dept of Cell Biol. and Mol. Med.

Copyright © The Japanese Pharmacological Society2-O-099 Oral Sessions
Exhaustive exploration of novel factors related to cardiomyocyte
proliferation using the cell cycle-sensitive protein FUCCI
Yuriko Wada1, Yusuke Kametani1, Shota Suzuki1, Ayaka Umeda1, Kosuke Nishinaka1,
Shota Tanaka1, Makiko Maeda2, Yoshiaki Okada1, Masanori Obana1,3,4,5, Yasushi Fujio1,3
1

Laboratory of Clinical Science and Biomedicine, School of Pharmaceutical Sciences, Osaka University,
Laboratory of Clinical Pharmacology and Therapeutics, School of Pharmaceutical Sciences, Osaka University,
3
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research
Initiatives (OTRI), Osaka University, 4Global Center for Medical Engineering and Informatics (MEI), Osaka
University, 5Radioisotope Research Center, Institute for Radiation Sciences, Osaka University
2

Copyright © The Japanese Pharmacological Society2-O-100 Oral Sessions
The microsomal prostaglandin E synthase-1/PGE2 /EP4 axis induces bloodflow recovery via recruitment of regulatory T cells
1

2

1

1

1

3

Hideki Amano , Kouji Eshima , Yoshiya Ito , Kanako Hosono , Ko Hatanaka , Shuh Narumiya ,4
5
Shizuo Akira , Masataka Majima
1

Department of Pharmacology, Kitasato University School of Medicine, 2Department of Immunology, Kitasato
University School of Medicine, 3Department of Drug Discovery Medicine, Kyoto University Graduate School of
Medicine, 4aboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University,
5
Department of Medical Therapeutics, Kanagawa Institute of Technology

Copyright © The Japanese Pharmacological Society2-O-101 Oral Sessions
Extracellular substrate stiffness-mediated regulation of endothelial cellfunction
Takayuki Okamoto, Haruki Usuda, Koichiro Wada
Dept. Pharmacol., Fac. of Med., Shimane Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-39 YIA
Behavioral and electrophysiological analysis of the analgesic and+antipruritic effects of the KCNQ (Kv7) K channel opener retigabine
Misa Oyama, Yuya Nakamura, Tomoko Kanzaki, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe
Lab. of Pharmacol., Sch. of Pharmacy, Kitasato Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-40 YIA
Sulfasalazine, an anti-rheumatic agent, relieves inflammatory pain by
reducing Toll-like receptor 4-mediated HMGB1 release from macrophages
Risa Domoto1, Hinano Tamura1, Fumiko Sekiguchi1, Maho Tsubota1, Masahiro Nishibori2,
Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Kindai Univ., 2Dept. Transl. Res. Drug Dev., Okayama Univ. Grad. Sch. Med.
Dent. Pharmaceut Sci.

Copyright © The Japanese Pharmacological Society

2-YIA-41 YIA
Involvement of PACAP/PAC1 receptor-evoked astroglial activation in amouse model for central post-stroke pain
Sameshima Yoshimune1, Yuki Kambe1, Ichiro Takasaki2, Atsuro Miyata1, Takashi Kurihara1
1Dept. Pharmacol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ., 2Dept. Pharmacol., Grad. Sch. Sci. Eng., Toyama.
Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-42 YIA
The effect of neutralizing antibody against high-mobility group box 1 on
cognitive impairment in mice with neuropathic pain
Natsuki Yoshimoto1, Kazue Nakashima1, Kazuto Ohata1, Yukio Nakamura1, Dengli Wang3,
Keyue Liu3, Hidenori Wake3, Yukio Ago2, Masahiro Nishibori3, Norimitsu Morioka1
1

Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Dept. of Cell. Mol. Pharmacol., Grad. Sch.
Biomed. Health Sci., Hiroshima Univ., 3Dept. Pharmacol., Grad. Sch. Med., Dent., Pharm., Okayama Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-43 YIA
Treatment of intracerebral hemorrhage with humanized a-HMGB1 mAb in
non-human primate brain
Dengli Wang1, Daiki Ousaka1, Handong Qiao1, Ziyi Wang2,3, Kun Zhao3, Kiyoshi Teshigawara1,
Masahiro Nishibori4
1

Dept. Pharmacol. Okayama Univ, 2Dept. Oral rehabil and regen med. Okayama Univ, 3Dept. Mol biol andDrug Dev. Okayama Univ.
biochem. Okayama Univ., 4Dept. Transl Res

Copyright © The Japanese Pharmacological Society

2-YIA-44 YIAResveratrol attenuates age-related muscle atrophy and motor dysfunction
by promoting autophagy in mice
Ryusuke Hosoda, Atsushi Kuno, Ryuta Nakashima, Seidai Asakura, Naotoshi Iwahara,
Iyori Nojima, Risa Kunimoto, Yoshiyuki Horio
Department of Pharmacology, Sapporo Medical University School of Medicine, Sapporo, Japan

Copyright © The Japanese Pharmacological Society

2-YIA-45 YIA
L-type amino acid transporter 1 in hypothalamic neurons regulates energy
and bone homeostasis
Kazuya Fukasawa, Gyujin Park, Eiichi Hinoi
Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-46 YIA
Nardilysin in hepatocyte regulates diet-induced thermogenesis via themodulation of brown adipose tissue activity
Nishi Kiyoto, Hirotaka Iwasaki, Mikiko Ohno, Shintaro Matsuda, Eiichiro Nishi
Dept. of Pharmacol., Shiga Univ. of Med. Sci.

Copyright © The Japanese Pharmacological Society

2-YIA-47 YIA
Identification of W09D10.4/PPTC7 as a novel AMPK-associated healthspanmodulatory factor by using C. elegans Healthspan Auto-monitoring System(C-HAS)
Yutaro Fukushima1,2, Yoshio Nakano1,2, Masataka Moriuchi1,2, Yuhei Kuwano1, Asuka Kagami1,
Kyoko Ozawa1, Mary Ann Suico1, Hirofumi Kai1, Tsuyoshi Shuto11Dept. Mol. Med. Grad. Sch. Pharmaceut. Sci., Kumamoto Univ., 2HIGO Program, Kumamoto Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-48 YIA
A continuous glucose level monitoring system for laboratory animals.
Yamashiro Kotaro1, Nobuyoshi Matsumoto1, Yuji Ikegaya1,2
1Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, 2Inst. AI and Beyond, Univ. Tokyo

Copyright © The Japanese Pharmacological Society

2-YIA-49 YIA
Development of a method to identify synapses associated with memory
formation
Onishi Taichi1, Hirokazu Sakamoto1, Yohei Okubo2, Kenzo Hirose1
1

The Univ. Tokyo., Grad. Sch. Med., Dept. Pharmacol., 2Dept. Pharmacology, Juntendo Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society

2-YIA-50 YIA
The role of the medial prefrontal cortex-perirhinal cortex pathway in the
nicotine-induced enhancement of object recognition memory in mice
Esaki Hirohito1, Akari Fukao2, Ayano Katsura2, Takanori Kitanaka2, Shoma Izumi1,
Akihiro Yamanaka3, Kazuki Nagayasu4, Shuji Kaneko4, Naoya Nishitani1,2, Satoshi Deyama1,2,
Katsuyuki Kaneda1,2
1

Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ., 2Lab. Mol. Pharmacol., Sch.
Pharmaceut. Sci., Kanazawa Univ., 3Dept. Neuroscience II, Res. Inst. Environmental Med., Nagoya Univ., 4Dept.
Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-51 YIA
Involvement of PGE2/EP1-tau phosphorylation signaling in the high salt
intake-induced hypertension and emotional and cognitive dysfunctions
Hisayoshi Kubota1, Akihiro Mouri1,6, Kazuo Kunisawa1, Masaya Hasegawa1, Hitomi Kurahashi1,
Aika Kosuge1, Yasuko Yamamoto2, Hiroyuki Tezuka3, Masanori Kugita4, Shizuko Nagao4,
Kuniaki Saito2,5,6, Toshitaka Nabeshima5,61

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Univ., 3Res. Promotion & Support Headquarters., Fujita Health Univ., 4Educ & Res.
Ctr. Anim. Models. Hum. Diseases., Fujita Health Univ., 5Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci.,
Fujita Health Univ., 6NPO. J-DO

Copyright © The Japanese Pharmacological Society

2-YIA-52 YIA
Serotonin neuron-specific transcriptome profiling in chronic SSRI-treatedmice and chronic social defeat stress model mice
Chihiro Andoh1, Masako Hagiwara1, Naoya Nishitani2, Kazuki Nagayasu1, Hisashi Shirakawa1,
Shuji Kaneko1
1

Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 2Lab. Mol. Pharmacol., Inst. Med.,
Pharmaceut., Health Sci., Kanazawa Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-53 YIA
Effect of intravenously administered adeno-associated virus encoding TrkB
gene on hippocampal neurogenesis
Yamashita Reiya, Takahiro Ishimoto, Yusuke Masuo, Yukio Kato
Fac. Pharm., Kanazawa Univ., Kakuma-machi, Kanazawa 920-1192, Japan

Copyright © The Japanese Pharmacological Society

2-YIA-54 YIA
Concomitant oral administration of Sulfasalazine with Febuxostat alleviates
neuropathic pain hypersensitivity through inhibition of SGK-1 in the spinal
cord
Yasukochi Sai1, Wakaba Yamakawa1, Akito Tsuruta1,2, Yuya Yoshida1, Naoya Matsunaga3,
Satoru Koyanagi1,2, Shigehiro Ohdo1
1

Dept. Pharmaceutics. Kyushu Univ., 2Dept. Glocal Healthcare Science. Kyushu Univ., 3Dept. ClinicalPharmacokinetics. Kyushu Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-55 YIA
Diabetic peripheral neuropathy is inhibited by thrombomodulin alfa in athrombin-dependent manner and aggravated by anticoagulants: novel
evidence from integration of preclinical and clinical studies
Shiori Tomita1,2, Haruka Nakano1, Maho Tsubota1, Masayuki Tanaka2, Kazuki Uchitani2,
Tatsuya Muranaka2, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Kindai Univ., 2Dept. Pharm., Kansai Med. Univ. Hosp.

Copyright © The Japanese Pharmacological Society

2-YIA-56 YIA
Lenvatinib causes mitochondrial impairment in skeletal muscles
Zheng Jing1, Naoto Nagata1, Jun-ichi Morishige1, Pingping Xu1, Hasan Nazmul1,
Hironao Okubo2, Hitoshi Ando1
1

Dept. Cell. Mol. Funct. Analysis, Kanazawa Univ. Grad. Sch. Med. Sci., 2Dept. Gastroenterology, Juntendo Univ.
Nerima Hosp.

Copyright © The Japanese Pharmacological Society

2-YIA-57 YIA
Gut microbiota associate with recurrence of cancer after surgery incolorectal cancer patients.
Isobe Junya1, Masahiro Hosonuma2,3,4,5, Atsuo Kuramasu2, Yoichiro Narikawa2,3,4,6,
Masakazu Murayama2,3,4,6, Midori Shida2, Takehiko Sambe7, Mayumi Tsuji3,4, Takuya Tsunoda5,
Shinichi Kobayashi8, Yuji Kiuchi3,4, Kiyoshi Yoshimura2,51

Dept. of Hosp. Pharmaceutics, Sch. of Pharm., Showa University, 2Dept. of Clin. Immuno Oncology, Clin. Res.
Inst. for Clin. Pharmacol. and Therap., Showa University, 3Dept. of Pharmacol., Showa University School of Med.,
4
Pharmacological Res. Ctr., Showa University, 5Div. of Med. Oncology, Dept. of Med., Showa University School ofMed., 6Dept. of Otorhinolaryngology,-Head and Neck Surgery, Showa University School of Med., 7Div. of Clin.
Pharmacol., Dept. of Pharmacol., Showa University School of Med., 8Clin. Res. Inst. for Clin. Pharmacol. andTherap., Showa University

Copyright © The Japanese Pharmacological Society

2-YIA-58 YIA
A Method Designed for Point-of-care System Monitoring Plasma
Concentration of an Anticancer Molecular Targeting Drug with Diamond
Electrode
Saiki Takuro1, Genki Ogata2,3, Seishiro Sawamura2, Olga Razvina4, Kota Watanabe4, Rito Kato4,
Kai Asai3, Yoshifumi Matsumoto1, Masato Moriyama1, Yasuo Saijo1, Yasuaki Einaga3,
Hiroshi Hibino2
1

Department of Medical Oncology, Niigata Univ, 2Division of Glocal Pharmacology, Department of Pharmacology,
Graduate School of Medicine, Osaka University, 3Department of Chemistry, Keio University, 4Niigata University
School of Medicine

Copyright © The Japanese Pharmacological Society

2-YIA-59 YIA
Impairment of aquaporin-4-mediated brain water flow and resultant waste
clearance in the mouse model of amyotrophic lateral sclerosis
Kazuki Adachi1, Mikako Hirose1, Mito Asano1, Yoichiro Abe2, Masato Yasui2, Hidemi Misawa1
1Div. Pharmacol., Fac. Pharm., Keio Univ., 2Dept. Pharmacol., Sch. Med., Keio Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-60 YIA
Diosgenin promotes long-distance axonal regeneration in the brain andrecovers memory deficits in a mouse model of Alzheimer‘s disease
Ximeng Yang, Chihiro Tohda
Section of Neuromedical Science, Inst. of Natural Med., Univ. of Toyama

Copyright © The Japanese Pharmacological Society

2-YIA-61 YIA
Involvement of mouse prefrontal cortex CB1 receptor in cognitive memory
Tokutake Tomohiro, Takashi Asano, Naotaka Izuo, Atsumi Nitta
Dept. of Pharmaceut. Therapy & Neuropharmacol., Fac. of Pharmaceut. Sci., Grad. Sch. of Med. & Pharmaceut.
Sci., Univ. of Toyama, Japan

Copyright © The Japanese Pharmacological Society

2-YIA-62 YIA
Combined efficacy of LY294002 and OTS964 in suppressing self-renewal oftemozolomide-resistant glioma stem cell populations
Sugimori Michiya1, Yumiko Hayakawa2, Yuri Nakagawa1, Ryoi Tamura1, Satoshi Kuroda2
1

Department of Integrative Neuroscience, Faculty of Medicine, University of Toyama, 2Department of Neurosurgery,
Faculty of Medicine, University of Toyama

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2-YIA-63 YIA
Induction of differentiation of pluripotent stem cells by Aurora-B kinase
inhibitor
Yasusei Kudo1, Takaaki Tsunematsu2, Yasuhiro Mouri11Dept. of Oral Biosci., Tokushima Univ., 2Dept. of Oral Pathobiol., Tokushima Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-64

YIA

Copyright © The Japanese Pharmacological Society

2-YIA-65

YIA

Copyright © The Japanese Pharmacological Society

2-YIA-66 YIA
Structural transition of human PTH1R revealed distinct molecular
recognition and molecular switch for sustainable activation
Kobayashi Kazuhiro1, Kouki Kawakami2, Tshukasa Kusakizako1, Hirotake Gono1,
Atsuhiro Tomita1, Kan Kobayashi1, Wataru Shihoya1, Keitaro Yamashita1,3, Tomohiro Nishizawa4,
Hideaki Kato1,5, Asuka Inoue2, Osamu Nureki1
1

Dept. of Biol. Sci., Grad. Sch. of Sci., The Univ. of Tokyo, 2Grad. Sch. of Pharmacol. Sci. & Fac. of Pharmaceut.
Sci, The Tohoku University, 3MRC laboratory of of Mol. Biol., 4Grad. Sci. of Med. Life Sci.. The Yokohama City
Univ., 5Grad. sch. of Arts and sci., Coll. of Arts and sci., The Univ. of Tokyo

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2-YIA-67

YIA
+

+

Localization and function of Na ,K -ATPase α3-isoform in the attached anddetached cancer cells
Takuto Fujii1, Takahiro Shimizu1, Mizuki Katou1, Shushi Nagamori2, Keiichi Kozumi3,
Junya Fukuoka4, Yoshiaki Tabuchi5, Akira Sawaguchi6, Tomoyuki Okumura7, Kazuto Shibuya7,
Tsutomu Fujii7, Hiroshi Takeshima8, Hideki Sakai1
1Dept. Pharmaceut., Fac. Physiol. Pharmaceut. Sci., Univ. Toyama., 2Dept. Lab. Med., Fac. Med., Jikei Univ. Sch.
Med., 3Lab. Drug Discov. Dev. Pre-disease., Fac. Pharmaceut. Sci., Univ. Toyama.,4Dept. Pathol., Grad. Sch.
Biomed. Sci., Nagasaki Univ., 5Div. Mol. Gen. Res., Life Sci. Res. Ctl., Univ. Toyama,6Dept. Anatomy,
Ultrastructural Cell Biol., Fac. Med., Univ. Miyazaki, 7Dept. Surg. Sci., Fac. Med., Univ. Toyama., 8Dept. Biol.
Chem., Grad. Pharmaceut. Sci., Kyoto Univ.

Copyright © The Japanese Pharmacological Society

2-YIA-68 YIA
Ninjinyoeito and Juzentaihoto inhibit Myeloid-derived suppressor cells(MDSC) migration and activation induced by cancer cells.
Rika Suzuki1, Yuta Kondo1, Kazuhito Murakami1, Li-Kun HAN2, Ryuji Takahashi2,
Yoichiro Isohama1
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2Kampo Research Laboratories, Kracie Pharma,
Ltd.

Copyright © The Japanese Pharmacological Society