1-P-001
Development of a fluorescent labeling method for the live-cellsuperresolution imaging of synaptic molecules.
Ishikawa Hiroki, Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose
Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo

Copyright © The Japanese Pharmacological Society1-P-002
Effects of orexin A on excitatory synaptic transmission in the rat nucleus
tractus solitarius
Yoshiaki Ohi, Daisuke Kodama, Akira Haji
Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.

Copyright © The Japanese Pharmacological Society1-P-003
Distinct sensitivities to bafilomycin and brefeldin to high potassium-evoked
DOPA and dopamine release from PC12 cells
Yoshio Goshima1, Miyu Inoue1, Daiki Masukawa1, Miki Hiasa2, Hiroshi Omote2
1

Dept. Mol. Pharmacol. Neurobiol., Yokohama City Univ., 2Dept. Membrane Biochem., Okayama Univ.

Copyright © The Japanese Pharmacological Society1-P-004
Elucidation of the mechanism of feeding control by VMH-PACAP via DMHgalanin in the hypothalamus
Yuki Kambe1, Trung Thanh Nguyen1, Norihito Shintani2, Hitoshi Hashimoto2, Takashi Kurihara1,
Atsuro Miyata1
1Dep. Pharmacol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ., 2Lab. Mol. Neuropharmacol., Grad. Sch.
Pharmaceut. Sci., Osaka Univ.

Copyright © The Japanese Pharmacological Society1-P-005
Role of fatty acid-binding protein 3 on the development of the medial
prefrontal cortex
Yui Yamamoto1,2, Masaki Ogata1, Yuji Owada2, Keiju Kamijo1
1

Dept. Anatomy, Tohoku Med. and Pharm. Univ.,2Dept. Organ Anatomy, Tohoku Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society1-P-006
Super-resolved 3D-STED microscopy reveals a layer-specific increase inexcitatory synapses in the hippocampal CA1 region of a model mouse ofautism spectrum disorder, Neuroligin-3 KO mice
Noriko Koganezawa1, Kenji Hanamura1, Manuela Schwark2, Dilja Krueger-Burg2,3,
Hiroshi Kawabe1
1

Gunma Univ. Grad. Sch. Med. Dept. Pharmacol., 2Max Planck Inst. Exp. Med. Dept. Mol. Neurobiol., 3Mainz Univ.
Med. Ctr. Inst. Microscopic Anatomy & Neurobiol.

Copyright © The Japanese Pharmacological Society1-P-007Diverse intracellular signaling pathways mediate the effects of neurotensin
on the excitability of type II neurons in the rat dorsolateral bed nucleus of
the stria terminalis
Masabumi Minami, Tomoyuki Kaneko, Ryuto Hara, Taiju Amano
Dept. Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society1-P-008
The effect of a miR-96-5p inhibitor delivery to brain using microbubbles andultrasound technology on neuroprotection and microglial activation
Chisato Kinoshita, Koji Aoyama
Dept. Pharmacol.,Teikyo Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society1-P-009
Promotion of cysteine-dependent glutathione synthesis by paraxanthine
Nobuko Matsumura1, Chisato Kinoshita1, Wattanaporn Bhadhprasit Sumida1, Toshio Nakaki2,
Koji Aoyama1
1

Dept. Pharmacol., Teikyo Univ. Sch. Med., 2Fac. Med. Tech., Teikyo Univ.

Copyright © The Japanese Pharmacological Society1-P-010
Anatomical identification of segregated network modules of the retrosplenialcortex along the cingulate cortex
Rumina Ueda1, Yuji Masaki1, Masahiro Yamaguchi1, Ryosuke Takeuchi1, Fumitaka Osakada1,2,3
1Lab. Cell. Pharmacol., Grad. Pharm. Sci., Nagoya Univ., 2Lab. Neural Info. Proc., Inst. Adv. Res., Nagoya Univ.,
3
NLS, Inst. Inn. Fut. Soc., Nagoya Univ.

Copyright © The Japanese Pharmacological Society1-P-011
Spatiotemporal dynamics of extracellular ADO revealed by geneticallyencoded ADO sensor in situ brain slice experiments.
Sakai Kent1, Eiji Shigetomi1,2, Hideaki Suzuki2, Schuichi Koizumi1,2
1

Yamanashi GLIA center, Interdisciplinary Graduate School of Medicine, University of Yamanashi,2Department of
Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi

Copyright © The Japanese Pharmacological Society1-P-012
Fetal hypoxia caused decrease of gliogenesis-related gene expression in rat
Kentaro Tokudome1, Masaaki Ueki1,2, Atsuki Nakamura1, Takehiro Yamaguchi1,
Shinji Matsunaga1, Shuhei Tomita1
1

Dep. Pharmacol., Grad. Sch. Med., Osaka City Univ., 2Dep. Anesthesiol., Nishiwaki Municipal Hospital

Copyright © The Japanese Pharmacological Society1-P-013
Region-specific astrocyte-microglia interaction promotes rotenone-induced
dopaminergic neurodegeneration
Ikuko Miyazaki1, Ryo Kikuoka1, Nami Isooka1, Shinki Murakami1, Chiharu Sogawa2,
Norio Sogawa3, Yoshihisa Kitamura4, Masato Asanuma11Dept. of Med. Neurobiol., Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., 2Dept. of Clin. Eng.,
Fac. of Life Sci., Hiroshima Inst. of Tech., 3Dept. of Mol. Eng. and Drug Dev. Sci., Grad. Sch. of Oral Med.,
Matsumoto Dental Univ., 4Dept. of Pharmacother., Sch. of Pharm., Shujitsu Univ.

Copyright © The Japanese Pharmacological Society1-P-014
PDGF-BB-stimulated brain pericytes release the mediators related to bloodbrain barrier dysfunction.
Seki Haruka1, Fuyuko Takata1, Yuki Egashira1, Takuro Iwao1, Miki Yokoya1,2, Miho Yasunaga1,2,
Naotaka Aridome1, Yuko Fukunaga3, Shinya Dohgu11Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2Dept. Pharmaceut. Care & HealthSci., Fac. Pharmaceut. Sci., Fukuoka Univ., 3Office for female researchers, Fukuoka Univ.

Copyright © The Japanese Pharmacological Society1-P-015
Postnatal establishment of CNS border-associated macrophages involves
Irf8 and Mafb
Yamasaki Ayato, Makoto Tsuda, Takahiro Masuda
Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharmceut. Sci., Kyushu Univ.

Copyright © The Japanese Pharmacological Society1-P-016
Effects of fluorocitrate, a selective inhibitor of astrocyte metabolism, on
pentylenetetrazole-induced seizures
Naofumi Kunisawa, Masaki Kato, Kazusi Takada, Misa Toyomasu, Ayako Fujiwara,
Saki Shimizu, Yukihiro Ohno
Dept. Pharmacol., Fac. Pharmacy, Osaka Med. Pharm. Univ.

Copyright © The Japanese Pharmacological Society1-P-017
HIF1α as a potential regulator of Schwann cell differentiation in peripheral
nerve.
Yuka Ujiie-Kobayashi, Shuji Wakatsuki, Toshiyuki Araki
Dept. Peripheral Nervous System Res., NCNP

Copyright © The Japanese Pharmacological Society1-P-018
DNA
interferon-β

TBK1-IRF3

Yoki Nakamura, Keisuke Ikeda, Momoka Iwamoto, Kazue Hisaoka-Nakashima,
Norimitsu Morioka
Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society1-P-019
Expression of equilibrative nucleoside transporters and activity regulation
by hydrogen peroxide in cultured astrocytes
Koh-ichi Tanaka1,2,3, Wataru Suzuki1, Yuri Kodama1, Takuto Izawa1, Kazuo Tomita1,2,
Kento Igarashi1,2, Nobue Kitanaka3, Junichi Kitanaka3, Tomoaki Sato2, Nobuyoshi Nishiyama1
1Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., 2Dept. Appl. Pharmacol., Kagoshima Univ.
Grad. Sch. Med. & Dent. Sci., 3Dept. Pharmacol., Hyogo Col. Med.

Copyright © The Japanese Pharmacological Society1-P-020
Involvement of microglial TRPV4 on glial scar formation
Junya Onodera1, Yuji Ikegaya1,2,3, Ryuta Koyama1,2
1

Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo, 2Inst AI Beyond, Univ Tokyo, 3CiNet

Copyright © The Japanese Pharmacological Society1-P-0212+

Microglial Ca signals in Alexander disease model
Kozo Saito1,2, Eiji Shigetomi1,2, Schuichi Koizumi1,2
1

Dept. Neuropharmacol. Interdiscip. Grad. Sch. Med. Univ. Yamanashi,2GLIA Ctr. Univ. Yamanashi

Copyright © The Japanese Pharmacological Society1-P-022
Elucidation of the mechanism of substantia nigra astroglial cell activation bymetabolic reactive oxygen species
Masato Ogura1, Ikuo Wada1,2
1

Fukushima Medical University School of Medicine, 2Fukushima Medical University School of Medicine

Copyright © The Japanese Pharmacological Society1-P-023
Effects of CSF1R inhibitor PLX3397 on reinforcement learning ability
Hiroyuki Ohta1, Minori Koga2, Ryuichi Nakagawa2, Hiroyuki Toda2, Toshiaki Ishizuka1
1

NDMC Pharmacol., 2NDMC Psychiatry

Copyright © The Japanese Pharmacological Society1-P-025
Functional regulation targeting nicotinic acetylcholine receptors using iPS
cell-derived microglia
Mari Sueyoshi1, Masaki Okawa1, Mayuko Takeda1, Teruki Matuhara1, Kaneyasu Nishimura1,
Shun Shimohama2,3, Kazuyuki Takata1
1Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan, 2Dept. Neurol., Sapporo Med. Univ. Sch. of Med.,
Sapporo, Japan, 3Jiseikai Memorial Hospital

Copyright © The Japanese Pharmacological Society1-P-026
Deep learning-based modeling of stress-induced epigenomic changes in
microglia and prediction of transcriptional networks
Hiroaki Fukuse, Masayuki Taniguchi, Tomoyuki Furuyashiki
Division of Pharmacology, Kobe University Graduate School of Medicine

Copyright © The Japanese Pharmacological Society1-P-027
NMDA-induced activation of the CaMKII-RhoA-Rho-kinase pathway regulates
aversive learning
Yasuhiro Funahashi1, Rijwan Uddin Ahammad2, Xinjian Zhang3, Emran Hossen1, Md
Omar Faruk2, Yifan Xu1, Keisuke Kuroda2, Daisuke Tsuboi1, Tomoki Nishioka1, Mutsuki Amano2,
Taku Nagai3, Kozo Kaibuchi1
1

Institute for Comprehensive Medical Science, Fujita Health University, 2Department of Cell Pharmacology,
Nagoya University Graduate School of Medicine, 3Division of Behavioral Neuropharmacology, Project Office for
Neuropsychological Research Center,

Copyright © The Japanese Pharmacological Society1-P-028
Anti-fatigue effects of 5-Aminolevulinic Acid in a mice Chronic Fatigue
Model
Chinatsu Ohmori1, Daisuke Yamada1, Kotaro Okano1, Eiko Kumamoto1, Kazumi Yoshizawa2,
Akiyoshi Saitoh1
1

Lab Pharmacol, Fac Pharm Sci, Tokyo Univ of Science, 2Lab Pharmacol and Therapeutics, Fac Pharm Sci, Tokyo
Univ of Science

Copyright © The Japanese Pharmacological Society1-P-029
Melanocortin 3/4 receptor in the dorsal raphe nucleus regulates maternalcare in lactating mice
Muroi Yoshikage, Toshiaki Ishii
Obihiro University of Agriculture and Veterinary Medicine

Copyright © The Japanese Pharmacological Society1-P-030
Enhanced sensitivity of epileptic seizure by deficit of hyperpolarization
activated cyclic nucleotide-gated (HCN) channel 1
Saki Shimizu1, Yuto Ishizaki1, Tatsuya Hattori1, Yuki Kotaru1, Sara Mishio1, Takashi Kuramoto2,
Yukihiro Ohno1
1

Dept. Pharmacol., Fac. Pharmacy, Osaka Med. Pharm. Univ., 2Dept. Anim. Nutr., Fac. Agric., Tokyo Univ. Agric.

Copyright © The Japanese Pharmacological Society1-P-031
What methods are physiologically or pharmacologically effective for
attracting female mice?
Yoshinori Ohnishi, Yukie Kawahara, Yuki Kishi, Yoko Ohnishi, Akinori Nishi
Kurume Univ. Dept. of Pharmacol.

Copyright © The Japanese Pharmacological Society1-P-032
Central effects of xenin in nesfatin-1 neurons in rat
Saito Shota, Hirofumi Hashimoto, Misaki Ishibane, Sangjon Pae, Shinpei Saito, Yoshie Reien,
Yuri Hirayama, Naohiko Anzai
Dept. Pharmacol, Grad. Sch. Med, Chiba Univ.

Copyright © The Japanese Pharmacological Society1-P-033
Generation and analysis of voltage-gated calcium channel β4 subunit
conditional knock-out mice
1

1

2

2

1

Katsumi Hayashida , Akito Nakao , Toru Yoshihara , Masahide Asano , Yasuo Mori
1Lab. Mol. Biol. Kyoto Univ., 2Inst. Lab. Anim. Kyoto Univ.

Copyright © The Japanese Pharmacological Society1-P-034
Boredom turns aversive stimuli into rewards
Yosuke Yawata1, Yu Shikano2, Keiko Ihara2, Kenji Tanaka2, Yuji Ikegaya1,3,4
1

Lab Chem Phamacol, Grad Sch Pharmaceut Sci, Univ Tokyo, 2Div Brain Sci, Keio Univ Sch of Med, 3Inst AI
Beyond, 4CiNet

Copyright © The Japanese Pharmacological Society1-P-035
A cannabinoid CB1 receptor knockout mouse demonstrates autism spectrum
disorder-like behaviors
1

1

1

2

Yoko Nawata , Mika Azukuri , Tsuyoshi Nishioku , Taku Yamaguchi
1

Dept. Pharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ., 2Dept. Pharmacother. andNeuropsychopharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.

Copyright © The Japanese Pharmacological Society1-P-036
What symptoms are associated with aggressive biting behavior of isolationreared mice?
Kento Igarashi1,2, Toshiko Kuchiiwa3,4, Satoshi Kuchiiwa4, Kazuo Tomita1,2, Koh-ichi Tanaka1,2,
Junichi Kitanaka5, Nobue Kitanaka5, Nobuyoshi Nishiyama2, Tomoaki Sato1
1

Dept. Applied Pharmacol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 2Div. Pharmacol., Dept. Pharm., Sch.
Pharm., Hyogo Univ. Health Sci., 3Dept. of Clinical Pshychol., Grad. Sch. Human Sci., Kagoshima Immaculate
Heart Univ., 4Dept. Neuroanatomy, Field of Neurol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 5Dept.
Pharmacol., Hyogo Col. Med.

Copyright © The Japanese Pharmacological Society1-P-037
Hexagonal columnar animal cage: Mechanism of social adaptation bycontrolling inter-individual communication in mice
Yuki Kurauchi, Keigo Matsuda, Yuki Ohta, Takahiro Seki, Hiroshi Katsuki
Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.

Copyright © The Japanese Pharmacological Society1-P-038
Effects of N-terminal fragment of canstatin on left ventricular hypertrophy ina rat model of angiotensin II-induced hypertension
Masanari Mori1, Akira Sugiyama1,2, Muneyoshi Okada1, Kosuke Otani1, Hideyuki Yamawaki1
1

Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ.,2Div. Pharmacol. Grad. Sch. Med. Dent. Sci. Niigata. Univ.

Copyright © The Japanese Pharmacological Society1-P-039
Expression of arresten and its role in the heart of rats with angiotensin IIinduced hypertension
Muneyoshi Okada, Syuya Kurihara, Masanari Mori, Kosuke Otani, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society1-P-040
Improvement effect of Eucommia ulmoides oliver derived geniposidic acidon hypoxia-induced pulmonary arterial hypertension
Tani Wakana1, Mari Hida1, Takuya Matsubara1, Hideaki Tagashira2, Tomo Kita2, Yutaro Tsujita2,
Tetsuya Hirata3, Takahiro Iwamoto2, Satomi Kita1,21

Dept. Pharmacol., Facul. Pharmaceut. Sci., Tokushima Bunri Univ., 2Dept. Pharmacol., Facul. Med., Fukuoka
Univ., 3R&D Ctr., Kobayashi Pharmaceut. Co., Ltd.

Copyright © The Japanese Pharmacological Society1-P-042
Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates
Pressure Overload-Induced Hypertrophic Responses in Cardiac Ventricle
and Exacerbates Dysfunction.
Terabayashi Takeshi1, Ichitaro Abe2, Katsuhiro Hanada3, Naohiko Takahashi2,
Toshimasa Ishizaki1
1

Oita Univ., Dept., Pharmacol., 2Oita Univ., Dept., Cardiol & Clin. Exam., 3Oita Univ., Clin. Eng. Res. Ctr

Copyright © The Japanese Pharmacological Society1-P-043
Phospholamban is degraded by parkin-mediated ubiquitination in failingheart
Shunichi Yokoe, Michio Asahi
Dept. Pharmacol. Fac. Med., Osaka Med. and Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society1-P-044
H216A, H611A

Cardiac-specific overexpression of HDAC6
can prevent thedevelopment of heart failure attributable to pressure overload in miceAtsushi Sanbe1, Yui Inomata1, Yohei Sawa2, Naoko Matsushita2, Nanae Ishida3, Rieko Higashio1,
Masamichi Hirose3
1

Div. Pharmacotherap. Sch. Pharm. Iwate Medi. Univ., 2Div. Card. Sch. Med. Iwate Medi. Univ., 3Div. Mol. Cell.
Pharmacol. Sch. Pharm. Iwate Medi. Univ.

Copyright © The Japanese Pharmacological Society1-P-045
Specific degrader of hematopoietic prostaglandin D synthase prevented theprogression of dilated cardiomyopathy in Duchenne muscular dystrophy.
Kosuke Aritake1, Yuma Maeyama1, Yukako Hosokawa1, Kengo Hamamura1, Hidetomo Yokoo2,4,
Norihito Shibata3, Yosuke Demizu4, Mikihiko Naito5
1Chem. Pharmacol. Lab., 2Grad. Sch. Med. Sci., Kyoto Pref. Univ. Med., 3Div. Biochem., Natl. Inst. Health Sci.,
4
Div. Organic Chem., Natl. Inst. Health Sci., 5Grad. Sch. Pharmaceut. Sci., Tokyo Univ.

Copyright © The Japanese Pharmacological Society1-P-046
Therapeutic effects of voluntary wheel running on cancer cachexia-induced
cardiac dysfunction: Approach from the perspective of Cardio-oncology
Miki Nonaka1, Susumu Ueno2, Ryo Kakigi3, Shosei Kishida4, Nagomi Kurebayashi5,
Takashi Murayama5, Kanako Miyano1, Kiyoshi Terawaki6, Takashi Sakurai5, Yasuhito Uezono1
1

Dept. Pain Control Res., Jikei Univ. Sch. Med., 2Dept. Occup. Toxicol., Inst. Ind. Ecol. Sci., Univ. Occup. Environ.
Hlth., 3Fac. Management & Information Sci, Josai International University, 4Dept. Biochem. Genetics., Kagoshima
Univ. Grad. Med. Dent. Sci, 5Dept. Pharmacol., Juntendo Univ. Sch. Med., 6Tsumura Res. Labo., Tsumura & Co.

Copyright © The Japanese Pharmacological Society1-P-047
SIRT1 protects the cardiomyocyte from doxorubicin-induced injury by
mediating DNA damage response via deacetylation of histone H2AX.
Kuno Atsushi, Ryusuke Hosoda, Naotoshi Iwahara
Dept. Pharmacol., Sapporo Med. Univ. Sch. of Med.

Copyright © The Japanese Pharmacological Society1-P-048
Assessment of drug-induced contractility by Electric Cell-substrate
Impedance Sensing in hiPSC-CMs
Satsuka Ayano, Sayo Hayashi, Syota Yanagida, Yasunari Kanda
Division of Pharmacology, National Institute of Health Sciences (NIHS)

Copyright © The Japanese Pharmacological Society1-P-049
Chronic toxicity assessment of BCR-ABL tyrosine kinase inhibitors using
human-induced pluripotent stem cell-derived cardiomyocytes
Hayashi Sayo, Ayano Satsuka, Shota Yanagida, Yasunari Kanda
Div. Pharmacol, NIHS

Copyright © The Japanese Pharmacological Society1-P-050
Effects of cigarette smoke extract (CSE) on the contraction, spontaneous2+
beating rate and intracellular Ca dynamics in adult and neonatal
cardiomyocytes
Jumpei Yasuda, Sakiko Matsumura, Hiroki Ishimura, Hiromasa Nagasu, Tomoe Y NakamuraNishitani
Dept. Pharmacol., Sch. Med., Wakayama Medical Univ.

Copyright © The Japanese Pharmacological Society1-P-051
The importance of sympathetic innervation for the postnatal heartdevelopment
Takuro Numaga-Tomita1, Hiroyuki Kawagishi1, Tsutomu Nakada2, Mitsuhiko Yamada1
1

Shinshu Univ., Grad. Sch. Med., Dept. Mol. Pharmacol., 2Shinshu Univ., Res. Center Adv. Sci. Tech.

Copyright © The Japanese Pharmacological Society1-P-052
The effects of a Src inhibitor on allergic airway inflammation and its
exacerbation of mice induced by house dust mite and poly(I:C)
Yuki Nishimoto1, Haruka Kai1, Daiki Kobayashi1, Reina Kobayashi1, Shoma Takahashi1,
Kaho Yamashita1, Nozomi Yamada1, Mizuki Yokota1, Genki Kimura1, Kazuhiro Ito2,
Yasuo Kizawa1
1

Lab. physiol. & Anat., Nihon Univ. Sch. Pharm., 2NHLI, Imperial College London, United Kingdom

Copyright © The Japanese Pharmacological Society1-P-053
Analysis of the role of macrophage senescence in lung fibrosis using
macrophage-specific p16 knockout mice
Yasuhiro Takenouchi, Kyosuke Makita, Keisuke Kitakaze, Kazuhito Tsuboi, Hironobu Ishimaru,
Yasuo Okamoto
Dept. Pharmacol., Kawasaki Med. Sch.

Copyright © The Japanese Pharmacological Society1-P-054
Effect of NP-1815-PX (a P2X4 receptor antagonist) on the contraction ofguinea pig tracheal smooth muscles
Keisuke Obara, Rikako Inaba, Mirai Kawakita, Kento Yoshioka, Yoshio Tanaka
Dept. Chem. Pharmacol., Facul. Pharmaceut. Sci., Toho Univ.

Copyright © The Japanese Pharmacological Society1-P-055
Eperisone treats pulmonary fibrosis via preferential cell death induction inlung fibroblasts
Ken-ichiro Tanaka1, Mikako Shimoda1, Toshifumi Sugizaki1, Maki Ikeda1, Ayaka Takafuji1,
Masahiro Kawahara1, Yamakawa Naoki2, Tohru Mizushima3
1

Musashino Univ Pharm Bio-Anal.Chem., 2Shujitsu Univ Pharm Medicinal chem., 3LTT Bio-Pharma

Copyright © The Japanese Pharmacological Society1-P-056
Effects of dexamethasone and roflumilast on neutrophilic asthma induced
by antigen and cigarette smoke in mice
Fuchikami Jun-ichi1, Maki Takahashi1, Yoshiyuki Suzuki1, Ryota Yagi1, Yasuki Akie1,
Kazutetsu Aoshiba2
1

CMIC Pharma Science Co., Ltd., 2Tokyo Medical University Ibaraki Medical Center

Copyright © The Japanese Pharmacological Society1-P-057
Role of histone ubiquitination in virus infection
Midori Hoshizaki, Yuki Fujiwara, Mara Anais Llamas Covarrubias, Yumiko Imai
Regulation for intractable Infectious Diseases, National Institutes of Biomedical Innovation, Health and Nutrition

Copyright © The Japanese Pharmacological Society1-P-058
Development of artificial antibody against receptor binding domain of SARSCoV-2 spike protein.
Masahiro Oike1, Hirotaka Takahashi2, Tatsuya Sawasaki2
1Dept. Pharmacol., Grad. Sch. Med.Sci., Kyushu Univ., 2Div. Cell-Free Sci., PROS, Ehime Univ.

Copyright © The Japanese Pharmacological Society1-P-059
Rat basophilic leukemia cell-derived chymase interacts with SRAS-CoV-2
spike protein
Shuang Liu, Erika Takemasa, Masaki Mogi
Dept. Pharmacol., Grad. Sch. Med., Ehime Univ.

Copyright © The Japanese Pharmacological Society1-P-060
Involvement of hematopoietic PGD2 synthase for delayed wound healing in
Streptozotocin-induced diabetic mice
1

1

2

Tomoko Kamauchi , Haruki Matsumoto , Yoshihiro Urade , Kosuke Aritake
1

3

Lab. of Ind. Pharm., Daiichi Univ. of Pharm., 2Ctr. for Sup. Pharmaceut. Edu., 3Lab. of Chem. Pharm., Daiichi
Univ. of Pharm.

Copyright © The Japanese Pharmacological Society1-P-061
Topical application of celecoxib inhibits skin fibrosis and the expression of
α- smooth muscle actin in bleomycin-induced sclerodema model mice
Hiroaki Matsunaga1, Shin Ishikane1, Takehiro Kishigami1, Eigo Ikushima1, Tomohiro Takiguchi1,2,
Yumiko Toyohira1, Fumi Takahashi1
1Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan,
Department of Clinical Pharmacology, Graduate School of Medicine Sciences, Kyusyu University

2

Copyright © The Japanese Pharmacological Society1-P-062
Hochuekkito ameliorates LPS-induced anxiety-like behavior by suppressing
interleukin-6 release
Soichiro Ushio1, Yoshihisa Kitamura2, Satoru Esumi1, Yoshito Zamami1
1Dept. Pharm., Okayama Univ. Hosp., 2Dept. of Pharmaceutical Care and Health Sciences, Dept. Pharmcol., Sch.
Pharm., Shujitsu Univ.

Copyright © The Japanese Pharmacological Society1-P-063
Effects of Perilla seed oil in combination with the nobiletin-rich ponkan
powder on the cognitive function in healthy Japanese elderly: Possible
supplementation for brain health in the elderly.
Michio Hashimoto1, Kentaro Matsuzaki1, Koji Maruyama2, Eri Sumiyoshi1, H Wa1, Setsu K3,
Miho Ohno3, Yoko Tanabe1, Yoko Kuroda4, K K2, Yasushi Ohizumi51Dept. of Environment. Physiol., Facult. of Med., Shimane Univ., 2Sankyo Holdings Co., Ltd., 3Kato Hosp. Jinjukai
Healthcare Corp., 4Dept. of Int. Med. III, Facult. of Med., Shimane Univ., 5Kansei Fukushi Res. Inst, Tohoku
Fukushi Univ.

Copyright © The Japanese Pharmacological Society1-P-064
Effects of Anredera cordifolia extract intake on learning and memory insenescence-accelerated mouse-prone 8 (SAMP8) mice
Eri Sumiyoshi1, Michio Hashimoto1, Shahdat Hossain1,2, Kentaro Matsuzaki1, Rafiad Islam1,
Yoko Tanabe1, Koji Maruyama3, Koji Kajima3, Hiroyuki Arai4, Yasushi Ohizumi5, Osamu Shido11Dept. Environ. Physiol., Fac. Med., Shimane Univ., 2Dept. Biochem. & Mol. Biol., Jahangirnagar Univ., 3Sankyo
Holdings Co., Ltd., 4Dept. Geriatr. Gerontol., Div. Brain Sci. IDAC., Tohoku Univ.,5Kansei Fukushi Res. Inst.,
Tohoku Fukushi Univ.

Copyright © The Japanese Pharmacological Society1-P-065
The preventive effect of Actinidia arguta (Sarunashi) juice on Parkinson's
disease onset through antioxidative activity
Yukino Ukai1, Yuki Kitamura2, Miyu Okamoto1, Mizuho Hasegawa1, Hanaka Fukuishi1,
Naho Hara1, Mayuko Sakanashi11Dept. Pathophysiol., Coll.Pharm., Kinjo Gakuin Univ., 2Dept. Health Sci., Coll.Pharm., Kinjo Gakuin Univ.

Copyright © The Japanese Pharmacological Society1-P-066
Atractylodin possesses anti-nociceptive effect through a long-lasting
activation of TRPA1
Kanda Hirosato1,2, Yoko Kogure1, Satoshi Yamamoto1, Koichi Noguchi2, Tsuyoshi Dai1,2
1School of Pharmacy, Hyogo University of Health Sciences, 2Dept. of Anatomy and Neuroscience, Hyogo College ofMedicine

Copyright © The Japanese Pharmacological Society1-P-067

Copyright © The Japanese Pharmacological Society1-P-068
Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastricmotility in dog
Yuta Shinohara1, Mohamed Elbadawy1,3, Megumi Yamanaka1, Haru Yamamoto1, Yomogi Sato1,
Amira Abugomaa1, Tatsuya Usui1, Kazuaki Sasaki1
1Dept. Vet Med., Fac. agr., Tokyo Univ of Agr and Tech.,2Division. Pet Health and Food., Iskara Industry CO.,LTD., 3Dept. Pharm., Fac. Vet med., Benha Univ.

Copyright © The Japanese Pharmacological Society1-P-069
G protein-coupled bile acid receptor TGR5 signaling regulates fibroblast
growth factor 21
Takao Hirai1, Hinako Hashimoto1, Naoko Murono2, Wataru Kakihana3, Hideki Imai1
1

Dept. Health Med. Sci. Ishikawa Pref. Nurs. Univ., 2Comm. Health Nurs. Ishikawa Pref. Nurs. Univ., 3Dept. Hum.
Sci. Ishikawa Pref. Nurs. Univ.

Copyright © The Japanese Pharmacological Society1-P-070
Dihydromyricetin suppresses cell proliferation via ERK1/2 in humanhepatocellular carcinoma cells.
Tsukasa Kobayashi1, Yuko Takeba1, Masanori Ootaki1, Yuki Ohta1, Keisuke Kida1,
Minoru Watanabe1,2, Taroh Iiri1, Naoki Matsumoto1
1

Department of Pharmacology, St Marianna University School of Medicine, 2Institute for Animal Experimentation,
St Marianna University Graduate School of Medicine

Copyright © The Japanese Pharmacological Society1-P-071
Development of a method for evaluating pain in sensory neurons using
236,880 electrode CMOS-MEA
Shibata Mikako, Naoki Matsuda, Xiaobo Han, Ikurou Suzuki
Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology,

Copyright © The Japanese Pharmacological Society1-P-072
Ready-to-use human neuron plates for pharmacological assays
2D culture plates

384 wellShionoiri Momoko, Rie Yamato, Toshihiko Hosoya
RICOH Company Ltd. Biomedical Business Center Biomedical Research and Development Department

Copyright © The Japanese Pharmacological Society1-P-073
seizure liability prediction method based on electrical activities in human
iPS cell-derived neurons using machine learning -Comparison of raster plot
model and parameter modelNaoki Matsuda, Ikuro Suzuki
Graduate School of engineering, Tohoku Institute of Technology

Copyright © The Japanese Pharmacological Society1-P-074
Toxicity risk assessment of pesticide-related compounds using human
iPSC-derived neurons
Yuto Ishibashi, Nami Nagafuku, Ikuro Suzuki
Grad. Sch. Eng., Tohoku Institute of Technology

Copyright © The Japanese Pharmacological Society1-P-075
Comparison of the Benchmark Dose (BMD) approach by four different typesoftware with No Observed Adverse Effect Level (NOAEL) approach fortumorigenicity in rodent bioassays of pesticides in Japan
Yukuto Yasuhiko1, Satoshi Machino2, Tatsuya Fujii2, Miwa Ishigami2, Masanori Aoki3, Fumi Irie4,
Midori Yoshida5, Yasunari Kanda11Division of Pharmacology, National Institute of Health Sciences, 2The First Risk Assessment Division, Food Safety
Commission Secretariat, Cabinet Office, 3Environmental Management Bureau, Ministry of the Environment,
4
Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu
University, 5Food Safety Commission of Japan

Copyright © The Japanese Pharmacological Society1-P-076
Molecular effects of cigarette smoke on airway epithelium cells
Tsunehito Higashi, Yosuke Mai, Yuichi Mazaki
Dept. Cell. Pharmacol., Grad. Sch. Med., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society1-P-077
L-type amino acid transporter 1 inhibitor JPH203 as a new therapeutic target
for castration resistant prostate cancer treatment
Saito Shinpei1,2, Shinichi Sakamoto2, Shota Saito1, Sangjon Pae1,2, Misaki Ishibane1,
Yoshie Reien1, Yuri Hirayama1, Hirofumi Hashimoto1, Tomohiko Ichikawa2, Naohiko Anzai1
1

Dept. Pharmacol, Grad. Sch. Med, Chiba Univ., 2Dept. Urology, Chiba Univ.

Copyright © The Japanese Pharmacological Society1-P-078
Pro-apoptotic protein p75-NTR associated cell death executor (NADE)
expression in chemical carcinogenesis of the rat liver
Yamada Mai1, Haruna Okada1, Chihiro Seto1, Yumiko Mizukawa1, Yoko Amagase1,2,
Tetsuro Urushidani1
1Dept. Pathophysiol. Fac. Pharmaceut. Sci., Doshisha Women's Coll. Liberal Arts, 2Fac. Pharm., Osaka Med. &Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society1-P-079
Development of liver metabolism and excretion test method utilizing acollagen vitrigel membrane: Advantages of HepG2-NIAS cells with enhanced
liver-specific function and structure by oxygenation culture
Miaki Uzu, Toshiaki Takezawa
Inst. Agrobiol. Sci., NARO

Copyright © The Japanese Pharmacological Society1-P-080
Evaluation of the anti-glycation effect and skin protection effect by asupplement containing brown algae extract powder. (A randomized,Doubleblind,Placebo-controlled, Parallel group study)
Naoto Takebe, Kousuke Yamauchi, Junji Yamamoto, Mitsuhiro Azuma, Toshihiko Matsumoto
Kaigen Pharma Co.,Ltd.

Copyright © The Japanese Pharmacological Society1-P-081
Association between effect of duloxetine on chronic orofacial
pain and expression of platelet serotonin transporter in patientswith burning mouth syndrome and atypical odontalgia
Nakamura Mariko1, Akira Yoshimi1,2, Akihiro Mouri3, Tatsuya Tokura2, Hiroyuki Kimura2,
Shinichi Kishi2, Tomoya Miyauchi2, Kunihiro Iwamoto2, Mikiko Ito4, Aiji Sato5, Norio Ozaki2,
Toshitaka Nabeshima6, Yukihiro Noda1,2
1Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Grad. Sch. Pharm, 2Dept. Psychiatry, Nagoya Univ. Grad.
Sch. Med., 3Dept. Regul. Sci. Eval. & Devel. Pharm. & Devices, Fujita Health Univ. Grad. Sch. Health Sci., 4Dept.
Oral & Maxillofac. Surg., Sch. Dent., Aichi Gakuin Univ., 5Dept. Anesthesiology, Sch. Dent., Aichi Gakuin Univ.,
6Adv. Diagnostic System Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ. Grad. Sch. Health Sci.

Copyright © The Japanese Pharmacological Society1-P-082
Effects of a novel hepatitis B antiviral drug in renal organic acid transporters
Misaki Ishibane1, Meika Kaneko1, Shota Saito1, Sangjon Pae1, Shinpei Saito1, Yoshie Reien1,
Yuri Hirayama1, Hirofumi Hashimoto1, Nobuyo Kuwata2, Hiroaki Mitsuya2, Naohiko Anzai1
1

Dept. Pharmacol, Grad. Sch. Med, Chiba Univ., 2NCGM

Copyright © The Japanese Pharmacological Society1-P-083
Possible involvement of transient receptor potential melastatin 4 channels in
the adrenergic contraction in mouse prostate smooth muscles
Pimpjong Kiattisak1, Taichi Mizutani2, Hayato Matsuyama1,2, Yasuyuki Tanahashi3,
Toshihiro Unno1,2
1

Dept. Basic. Vet. Sci., Joint Grad. Sch. Vet. Sci.,2Lab. Vet. Pharmacol., Gifu Univ., 3Dept. Adv. Life Sci., Kyoto
Sangyo Univ.

Copyright © The Japanese Pharmacological Society1-P-084
Role of TRPV1 in hyaluronan-induced apoptosis avoidance in MCF-7 cells
Yuki Kaguchi, Yuto Hoshino, Yui Fukuyama, Takuya Yamaguchi, Jun Yamazaki
Lab. Vet. Pharmacol., Dept. Vet. Med., Nihon Univ. Coll. of Biores. Sci.

Copyright © The Japanese Pharmacological Society1-P-085
Phosphorylation of Annexin A2 is involved in activation of AKT uponendothelin-1 stimulation in melanoma cells
Yuichi Mazaki, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa
Dept. Cell. Pharmcol., Grad. Sch. Med., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society1-P-086
Dephosphorylation of GABA B receptor subunit by over-expression of protein
phosphatase 5.
Kyosuke Uno, Takuro Yoshinaga, Kosuke Kawarai, Toshihiko Kinjo, Nobuyuki Kuramoto
Lab. Mol. Pharmacol., Fac of Pharm. Sci. , Setsunan Univ.

Copyright © The Japanese Pharmacological Society1-P-087
Dual regulation of ERK phosphorylation by activation of Gq-protein- andarrestin-mediated pathways via histamine H1 receptors
Shotaro Michinaga, Ayaka Nagata, Shigeru Hishinuma
Dept. Pharmacodynamics, Meiji Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society1-P-088
Contributions of two enantiomers of the citalopram-induced blockade ofNav1.5 voltage-gated sodium channels current
Yoshihiko Nakatani1, Taku Amano2
1

Department of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare,Tochigi Mental Health Welfare Center

2

Copyright © The Japanese Pharmacological Society1-P-089
Reactivity of TRPA1 to menthol differs between mouse and dog
Takuya Yamaguchi1, Ayana Matsuoka1, Kunitoshi Uchida2, Jun Yamazaki1
1

Lab. Vet. Pharmacol., Dept. Vet. Med., Nihon Univ. Coll. of Biores. Sci.,2Lab. Funct. Physiol., Sch. Food Nutr. Sci.,
Univ of Shizuoka

Copyright © The Japanese Pharmacological Society1-P-090
The role of TRPA1 in hypoxic response of the carotid body
Tomoya Kawamoto1, Akito Nakao1, Barneo José López2,3, Yasuo Mori1
1

Dept. Synthetic Chem.& Biol. Chem. Grad. Sch. Eng. Kyoto Univ., 2Instituto de Biomedicina de Sevilla,
3
Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla

Copyright © The Japanese Pharmacological Society1-P-091
Voltage-gated chloride channels control mitochondrial membrane potential
Junji Suzuki, Yuriy Kirichok
UCSF

Copyright © The Japanese Pharmacological Society1-P-092
One amino acid mutation of prostanoid EP4 receptor altered its signaling
profiles.
Akito Onishi1, Akiko Higashiyama1, Shunya Yanagawa1, Naofumi Seira2, John W Regan3,
Kento Ohkawachi4, Masaya Denda4, Keijo Fukushima1, Akira Otaka4, Hiromichi Fujino1
1Dept. Pharmacol. for Life Sci., Fac. of Pharmaceut. Sci., Tokushima Univ., 2Lab. Chem. Pharmacol., Grad. Sch.
Pharmaceut. Sci., Chiba Univ., 3Dept. Pharmacol. & Toxicol., Coll. of Pharm., The Univ. of Arizona, 4Dept.
Bioorgan. Synthe. Chem., Grad. Sch. of Pharmaceut. Sci., Tokushima Univ.

Copyright © The Japanese Pharmacological Society1-P-093
Metabolites of Prostaglandin D2 act as biased agonists for D type prostanoid
receptors
1

1

1

2

1

Kanaho Senoo , Hitomi Yamamoto , Suzu Endo , John W. Regan , Keijo Fukushima ,1
Hiromichi Fujino
1

Dept. Pharmacol. for Life Sci., Fac. of Pharmaceut. Sci., Tokushima Univ., 2Dept. Pharmacol. & Toxicol., Coll. of
Pharm., The Univ. of Arizona

Copyright © The Japanese Pharmacological Society1-P-094
Identifications of novel drugs of GIRK channel and its disease-causing
mutants
I-Shan Chen, Tomoe Nishitani
Dept. Pharmacol. Wakayama Medical Univ.

Copyright © The Japanese Pharmacological Society1-P-095
Development of anti-mouse CC chemokine receptor 8 monoclonal antibody
C8Mab-2
1

2

2

1

1

Masaki Saito , Tomohiro Tanaka , Teizo Asano , Hiroyuki Suzuki , Mika K. Kaneko ,1,2
Yukinari Kato
1

Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med., 2Dept. Antib. Drug Dev., Tohoku Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society1-P-096
A newly discovered MRGPRA3 agonist by high-throughput screening
induces scratching behaviors
Tomohiro Yamashita1, Mayu Ito2, Yuka Kawanami2, Keisuke Koga2,3, Kensho Kanehisa2,4,
Shiori Fujii2,4, Jose Caaveiro1, Makoto Tsuda2,41

Dept. Global Healthcare, Grad. Sch. Pharma. Sci, Kyushu Univ., 2Dept. Life Innov., Grad. Sch. Pharma. Sci.,
Kyushu Univ., 3Dept. Neurophysiology, Hyogo Col. Med., 4Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci.,
Kyushu Univ.

Copyright © The Japanese Pharmacological Society1-P-097
Inhibitory effects of CRAC channel current by anti-depressantFujimura Kanna, Minoru Wakamori
Dept. Dent. Pharmacol. Tohoku Univ.

Copyright © The Japanese Pharmacological Society