第 47 回

日本基礎老化学会大会
プログラム

The 47th Annual Meeting of
the Japan Society for BiomedicalGerontology
PROGRAM1

6 月 15 日(土) / 15 June (Sat)≪大講義室≫
9:00～9:10

開会の辞
福井 浩二 (第 47 回日本基礎老化学会大会長，芝浦工業大学)

9:10～10:10 一般口頭発表Ⅰ
座長: 水之江 雄平 (東京理科大学)
小林Ⅰ-01/ Y正樹 (お茶の水女子大学)

Mixed antioxidant supplement improved the coordination ability of aged mice
Akari Nakamura (Shibaura Institute of Technology)

Ⅰ-02/ Y・S

Effects of Accumulated PARIS on Aging-related Diseases
Hiroto Fukai (Laboratory of Molecular Pathology and Metabolic Disease, Faculty of
Pharmaceutical Science, Tokyo University of Science)

Ⅰ-03/ Y・S

Effect of dietary protein ratio on lipid metabolism in the mouse liver
Jialin Chen (Molecular Regulation of Aging, Tokyo Metropolitan Institute for Geriatrics
and Gerontology, Tokyo Biotechnology Technical School)

Ⅰ-04/ Y・S

Systemic and focal effects of the mitochondrial stress-induced mitokine GDF15 in theadipose tissue
Tomoyoshi Fukuoh (Laboratory of Molecular Pathology and Metabolic Disease, Facilityof Pharmaceutical Science, Tokyo University of Science)

Ⅰ-05/ Y・S

Investigation of renal injury models with different concentrations of adenine
Shunki Otomo (Graduate School of System Engineering and Science, Shibaura Instituteof Technology)

10:10～10:15 休憩
10:15～11:15 一般口頭発表Ⅱ
座長: 内田 さえ (東京都健康長寿医療センター研究所)
嶋本
Ⅱ-01/ Y・S顕 (山口東京理科大学)

MIPEP regulates adipocyte differentiation by maintaining the quantity and quality ofmitochondria
Mamiko Ishimatsu (Department of Pharmaceutical Science, Graduate School of
Pharmaceutical, Tokyo University of Science)

Ⅱ-02/ S

A novel type of astrocytes expressing Olig2 in mouse dentate gyrus and their response
to intermittent hypoxia
Shoichiro Omura (Department of Histology and Neuroanatomy, Tokyo Medical University)

Ⅱ-03/ Y・S

System xc-/xCT in microglia is a regulator of neuropsychiatric disorder in vitamin E
deficient mice
Hidetoshi Nagamine (Tottori University)

Ⅱ-04/ S

Co-expression of POMC and Prox1 delineates newly generated POMC neurons in thehypothalamus through lifetime
Rina Ogawa (Department of Histology and Neuroanatomy, Tokyo Medical University)2Ⅱ-05/ S

Cerebral blood flow responses to trigeminal olfactory stimulation and its nicotinic
cholinergic regulation
Daichi Morihara (Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo
University of Agriculture and Technology)

11:15～11:30 移動≪501 教室≫
11:30～12:15 スポンサードセミナー (TIMA Tokyo 株式会社)「老化治療の最前線」
講師：犬房 春彦 (岐阜大学科学研究基盤センター 共同研究講座 抗酸化研究部門 特任教授)
座長: 福井 浩二 (芝浦工業大学)≪ホワイエ≫
12:15～13:45 ポスター討議 (タイトルについては P8～9 に掲載)
≪大講義室≫
13:45～14:30 企業シンポジウム
座長: 中川 久子 (雪印メグミルク株式会社)
柳井 修一 (東京都健康長寿医療センター研究所)
1.

The effectiveness of Lactic Acid Bacteria for “Health Aging”
Hisako Nakagawa (MEGMILK SNOW BRAND Co., Ltd)

2.

Electron Spin Resonance (ESR), Instrument for detecting radicals
Yumi Nakai (JEOL Ltd)

3.

Rare sugar ～Potential for healthy aging～
Akane Kanasaki (Matsutani Chemical Industry Co., Ltd)

14:30～14:35 休憩14:35～15:35 日本組織培養学会とのジョイントシンポジウム
座長: 片岡健 (岡山理科大学)

中村 庸輝 (広島大学)
1.

Innovative Gravity-Driven and Electric-Assisted Microfluidic Culture System for Human Induced
Pluripotent Stem Cell Assays
Kiyoshi Ohnuma (Nagaoka University of Technology)2.

Development of cell self-aggregation technique-based tissue engineering.
-Challenges for applications in regenerative medicine and 3D culture modelsRyosuke Iwai (Okayama University of Science)3.

Acute brain slice preparations for approaching cellular and molecular mechanisms of higher
brain function
Sho Kakizawa (Tokyo Metropolitan Institute for Geriatrics and Gerontology)4.

Microglial xCT is a novel therapeutic target for Alzheimer’s disease/ Y
Yugo Kato (Tottori University)

15:35～15:45 休憩3

15:45～16:25 医工連携シンポジウム
座長: 福井 浩二 (芝浦工業大学)
特別講演Ⅰ:「関節運動の絶対的な強さから瞬間的な強さへのシフト ―高齢者の姿勢制御能力向上に向けた取り組み―」
講師: 赤木 亮太 (芝浦工業大学)
特別講演Ⅱ:「赤血球が流れから受ける物理刺激・機械的損傷・膜酸化現象・Aging との関連性」
講師: 渡邊 宣夫 (芝浦工業大学)
16:25～16:30 休憩
16:30～18:10 日韓合同シンポジウム/Japan-Korea Joint Symposium
座長/Chairs: 柿澤昌 (東京都健康長寿医療センター研究所)
Cheol-Koo Lee (Korea University)
1.

Genomic approach to identify the role of DNA repair in longevity using genomic databases
Young Rok Seo (Department of Life Science, Institute of Environmental Medicine, DonggukUniversity)

2.

Adverse Effects of Environmental Pollutants on Neural Stem Cells and Adult Hippocampal
Neurogenesis
Jaewon Lee (Department of Pharmacy, College of Pharmacy, Pusan National University)

3.

Suppression of neutrophil mitigates acute aortic dissection in H2-inhalation therapy
Masumi Iketani (Biol. Process Aging, TMIG)

4.

Lifespan extender rapamycin and TOR genetics in budding yeast cells
Cheol-Koo Lee (Korea University, Seoul)

5.

Effects of resistance training on fibro-adipogenic progenitors in aging skeletal muscle
Yung-Li Hung (Japan Society for the Promotion of Sciences, Juntendo University)

6.

The aging process is an evolutionary phenomenon from the tumor's perspective
Tae Jun Park (Department of Biochemistry and Molecular Biology, Ajou University School ofMedicine)

7.

Changes of nucleocytoplasmic trafficking in cellular senescence
Young-Sam Lee (Department of New Biology, DGIST)

8.

Changes in mitochondrial fusion and fission-related gene and protein expression in AD
transgenic mice/ Y・S
Anna Seino (Times Graduate School of System Engineering and Science, Shibaura Institute ofTechnology)≪豊洲カフェテリア: 交流棟 3F≫

18:30～20:30 情報交流会/Banquet4

6 月 16 日(日) / 16 June (Sun)≪大講義室≫
9:00～10:00 一般口頭発表Ⅲ
座長: 丸山 光生 (国立長寿医療研究センター)
清水 孝彦 (国立長寿医療研究センター)
Ⅲ-01/ S

HIF-1α activation by fatty acid bound to albumin induces cell proliferation andsenescence in renal proximal tubular epithelial cells
Mio Narita (Graduate School of Medical Science, Kitasato University)

Ⅲ-02/ Y

Role of plasma membrane phospholipid in cellular senescence
Kaori Kanemaru (Department of Applied Biological Science, Faculty of Science andTechnology, Tokyo University of Science)

Ⅲ-03/ Y・S

DNA damage induction by exosomes secreted from senescent cells
Yukihiro Ikegaki (Department Biology, Graduate School of Science)

Ⅲ-04/ YThe Impact of senescent cells on the process of lung regeneration: possible involvementof a nuclear receptor signaling
Mikako Hirose (Molecular and Cellular Aging, Tokyo Metropolitan Institute for
Geriatrics and Gerontology)

Ⅲ-05/ S

Molecular basis of cellular senescence triggered by CDK inhibition
Yuto Matsuo (Tokyo University of Science)

10:15～10:20 休憩
10:05～10:55 一般口頭発表Ⅳ
座長: 三浦 ゆり (東京都健康長寿医療センター研究所)
木村 展之 (岡山理科大学)
Ⅳ-01/ Y

Comprehensive analysis of age-related changes in transcriptome diversity by single
cell RNA-seq data analysis
Daigo Okada (Center for Genomic Medicine, Graduate School of Medicine, Kyoto University)

Ⅳ-02/ Y・S

Lysine Specific Demethylase 1 (LSD1) suppresses cellular senescence by epigeneticallyregulating Sirtuin-4 in a riboflavin uptake-dependent manner
Taiichi Osumi (Department of Biology, Graduate School of Science, Kobe University)

Ⅳ-03/ Y・S

Effect of vitamin C deficiency on age-associated genes in mouse liver
Yukari Mitsumaru (Molecular Regulation of Aging, Tokyo Metropolitan Institute for
Geriatrics and Gerontology, Department of Systems Engineering and Science, ShibauraInstitute of Technology)

Ⅳ-04/ Y・S

Effects of vitamin C on epigenetic modifications in C2C12 cells
Tatsuki Minowa (Molecular Regulation of Aging, Tokyo Metropolitan Institute for
Geriatrics and Gerontology, Department of Biological Sciences, Tokyo Metropolitan
University)

10:55～11:00 休憩
5

11:00～12:15 一般口頭発表Ⅴ
座長: 町田 修一 (順天堂大学)
小野 悠介 (熊本大学/東京都健康長寿医療センター研究所)
Ⅴ-01/ Y・S

The impairment of chronic oxidative stress-induced autophagy causes sarcopenia withindividual atrophy in mice
Rikuto Toda (Department of Applied Physics and Chemistry, School of Engineering, TokaiUniversity)

Ⅴ-02/ YHox based positional identities influence myogenesis in adult skeletal muscle
Ryosuke Okino (Muscle Biology Laboratory, Tokyo Metropolitan Institute for Geriatricsand Gerontology)

Ⅴ-03/ S

Effects of aging and sex on ribosome biogenesis in the skeletal muscle
Shota Fusen (Graduate School of Health and Sports Science, Juntendo University)

Ⅴ-04/ Y

Analysis of aged mice-specific abnormal muscle fibers reveals new insights intomolecular mechanisms of sarcopenia
Naoki Ito (Brain-Skeletal Muscle Connection in Aging Project Team, Geroscience
Research Center, National Center for Geriatrics and Gerontology)

Ⅴ-05/ Y・S

Effects of AGEs on cellular senescence in C2C12 skeletal muscle cells
Ryota Iyama (Graduate School of Human and Environmental Studies, Kyoto University)

12:15～12:30 移動≪501 教室≫
12:30～13:15 スポンサードセミナー (株式会社タケナカ)「産学連携における室戸海洋深層水の利用促進に向けた取り組み」
講師: 福井浩二 (芝浦工業大学 システム理工学部 生命科学科 分子細胞生物学研究室 教授)
座長: 加藤 優吾 (鳥取大学)
13:15～13:20 休憩
13:20～14:35 一般口頭発表Ⅵ
座長: 大澤 郁朗 (東京都健康長寿医療センター研究所)
石井 恭正 (東海大学)
Ⅵ-01/ Y・S

Hydrogen rich water-induced thinning of mucus layer with changes of bacterial florain the small intestine
Yui Ueta (Biological Process Aging, Tokyo Metropolitan Institute for Geriatrics andGerontology, Graduate School Life Science, Toyo University)

Ⅵ-02/ Y・S

Enhancement effect of exercise training in mice treated with deep-sea water extractadded water-treated mice
Nagisa Tomioka (Graduate School of System Engineering and Science, Shibaura Instituteof Technology)

Ⅵ-03/ Y

Effects of glucosamine on human colonic microbiota in an in vitro model
Tomoya Shintani (Kobe University)6

Ⅵ-04/ Y・S

The Effects of Tocotrienols on Mice Pre-Fed on a High-Fat Diet
Shuntaro Richard Kashiwaya (Graduate School of System Engineering and Science, Shibaura
Institute of Technology)

Ⅵ-05/ Y・S

The effects of royal jelly on stem cell aging
Yukie Kande (Shiga University of Medical Science)

Ⅵ-06/ Y

Senomrphic effect of royal jelly in epidermal keratinocyte
Yukie Nakagawa (Yamada Bee Company, Inc.)

14:35～14:40 休憩
14:40～15:25 教育講演
「若い研究者たちへ ―私の研究の黒歴史を話すよ―」
講師: 遠藤 昌吾 (東京都健康長寿医療センター研究所 研究部長)
座長: 石神 昭人 (東京都健康長寿医療センター研究所)
15:25～15:40 授賞式
15:40～15:45 理事長挨拶
石神 昭人 (日本基礎老化学会 理事長，東京都健康長寿医療センター研究所 副所長)
15:45～15:55 次回大会長挨拶
堀田 晴美 (東京都健康長寿医療センター研究所)
15:55～16:00 閉会の辞
福井 浩二 (第 47 回日本基礎老化学会 大会長，芝浦工業大学)

7

6 月 15 日(土) 12:15～13:30 / 15 (Sat) June 12:15～13:30≪ホワイエ≫ ポスター発表会場
P-1. Age-related changes in the muscle characteristics of forelimb and hindlimb of senescenceaccelerated mouse P8 and R1 strains
Keiko Odera (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University)
P-2. Age-related changes of Tau in cat brain
Nobuyuki Kimura (Department of Veterinary Associated Science, Faculty of Veterinary Medicine,
Okayama University of Science (OUS))

P-3. Renal function in aged C57BL/6J mice. Age-related apolipoprotein A-II amyloid deposition
impaired the function independently of kidney aging
Hiroki Miyahara (Shinshu University)P-4. Assessment of chronological aging and longevity intervention in healthy dogs
Takashi Ito (RIKEN CSRS)
P-5. Why do mice fed egg only diet live healthy?
Nishio Naomi (Department of school health, Faculty of Education, Saitama University)P-6. Role of hippocampal microglia in anxiodepressive-like behaviors of aged mice
Yoki Nakamura (Department of Pharmacology, Hiroshima University)P-7. Regular voluntary exercise increases NAD+ levels and cognitive function in aged mice
Jimmy Kim (Department of Physiology, Graduate School of Health and Sports Science, JuntendoUniversity)P-8. Muscle-Derived Seno-Suppressor: Unraveling the Novel Link to Exercise Therapy
Hiromichi Tsushima (Tokyo Metropolitan Institute for Geriatrics and Gerontology)
P-9. Development of a fluorescent GABA sensor for drug discovery
Kenji Takikawa (Tokyo Metropolitan Institute of Gerontology)
P-10. Characterization of senescent cells derived from human fetal fibroblasts with defective
oxidative phosphorylation
Yasunori Fujita (Biological Process of Aging, Tokyo Metropolitan Institute for Geriatrics andGerontology)
P-11. Contribution of sympathetic nerve activity on skeletal muscle contractility in young andaged rats
Harumi Hotta (Department of Autonomic Neuroscience, Tokyo Metropolitan Institute for Geriatricsand Gerontology)

P-12. Effect of a traditional Japanese herbal medicine, Ninjin’yoeito, on static and dynamicchanges in cerebral cortical arteriolar diameters
Nobuhiro Watanabe (Department of Autonomic Neuroscience, Tokyo Metropolitan Institute for
Geriatrics and Gerontology)

P-13. Age-related impacts of the defective programmed cell death pathway on longevity in C. elegans
Sumino Yanase (Daito Bunka University School of Sports & Health Science)P-14. Application of senescent cell removal model mice (tdTomato/human HBEGF knock-in mice) as atool for aging research
Mitsuo Maruyama (National Center for Geriatrics and Gerontology, Nagoya University Graduate
School of Medicine)P-15. Diversity of SASP factors and their physiological roles in cellular senescence process
Yoichiro Kawabe (National Center for Geriatrics and Gerontology)
P-16. The relationship between ROS-induced neurite degeneration, disruption of intracellular Ca2+
homeostasis and mitochondrial dynamics
Koji Fukui (Shibaura Institute of Technology)8

P-17. Milk derived sialylglycopeptide concentration induce BDNF production in SH-SY5Y
neuroblastoma cells.
Hisako Nakagawa (Milk Science Research Institute, MEGMILK SNOW BRAND Co. Ltd.)
P-18. Inhibitory effect of H2-inhalation on thrombolytic tPA-induced hemorrhagic transformationof cerebral infarction
Kennosuke Sato (Biological Process Aging, Tokyo Metropolitan Institute for Geriatrics andGerontology, Life Science, Toyo University)
P-19. Induction of tissue-specific premature stem cell aging promotes senescence-likedeterioration in remote organs
Hayato Kaneda (Shiga University of Medical Science)P-20. Effect of basal forebrain stimulation on extracellular acetylcholine release and regional
blood flow in the piriform cortex
Jura Moriya (Department of Autonomic Neuroscience, Tokyo Metropolitan Institute for Geriatrics andGerontology, Tokyo University of Agriculture and Technology)
P-21. Analysis of Selective mRNA Splicing in Adipose tissue following Caloric Restriction
Yuhei Mizunoe (Laboratory of Molecular Pathology and Metabolic Disease, Faculty of PharmaceuticalScience, Tokyo University of Science)P-22. MMP-2 regulation improves age-related skin pathologies caused by oxidative stressShuichi Shibuya (Aging Stress Response Research Project Team, National Center for Geriatrics andGerontology)

P-23. Study of skeletal muscle aging using human iPS cells
Makoto Shimizu (Graduate School of Humanities and Sciences, Ochanomizu University, Graduate Schoolof Agricultural Sciences, The University of Tokyo)

P-24. Assessment of physical and cognitive decline in aging mouse model
Shuichi Yanai (Tokyo Metropolitan Institute for Geriatrics and Gerontology)
P-25. Age-associated changes in the amount of nucleotide sugars in mouse tissues
Rieko Imae (Molecular Glycobiology, Tokyo Metropolitan Institute for Geriatrics and Gerontology)
P-26. Age-related changes in the N-glycan expression of mouse lung
Keiko Akasaka-Manya (Molecular Glycobiology, Research Team for Mechanism of Aging, Tokyo
Metropolitan Institute of Gerontology)

P-27. Change of fucosylated N-glycans in plasma proteins from semi-supercentenarians
Hiroki Tsumoto (Tokyo Metropolitan Institute for Geriatrics and Gerontology)
P-28. A transcriptomic atlas of the adult mouse skeletal muscle and satellite cells: toward
understanding age-related sarcopenia
Yuuki Gouda (Muscle Biology Laboratory, Tokyo Metropolitan Institute for Geriatrics andGerontology)

P-29. Approaches for Identifying of Active Substances in Hypochlorous Acid-Based Disinfectants:
Application of Absorption Spectrophotometry and Iodometry
Yuta Okada (Graduate School of System Engineering and Science, Shibaura Institute of Technology)
P-30. The comparison of dissolved components, effective chlorine concentration and free chlorine
concentration between electrolyzed and non-electrolyzed hypochlorous acid water
Kenta Sugiyama (Graduate School of System Engineering and Science, Shibaura Institute ofTechnology)

P-31. Analysis of sodium chlorite and acidified sodium chlorite by various measurement methods
Ayuta Kishimoto (Graduate School of Functional Control Systems, Shibaura Institute of Technology)

9