2-P1-01 Poster Sessions
Distinct role of dopamine in the PFC and NAc in retrieval of cocaine reward
memoryYukie Kawahara1, Yoshinori Ohnishi1, Yoko Ohnishi1, Hiroshi Kawahara2, Akinori Nishi1
1

Dept. of Pharmacol., Kurume Univ. Sch. of Med., 2Dept. of Dent. Anesthesiology, Tsurumi Univ. Sch. of Dent. Med.

Copyright © The Japanese Pharmacological Society

2-P1-02 Poster Sessions
Investigation of the roles of orexin receptor subtypes in regulation of basal
dopamine efflux in the nucleus accumbens of freely moving rats
Kawashima Hiroki, Yuri Aono, Tadashi Saigusa
Dept. Pharmacol., Nihon Univ. Sch. Dent. at Matsudo

Copyright © The Japanese Pharmacological Society

2-P1-03 Poster Sessions
The expression of G protein-coupled receptor 3 modulates presynaptic
function in differentiated PC12 cells
Humiaki Ikawa1, Shigeru Tanaka1, Tomohiro Noguchi2, Kenta Sasaki2, 佳奈 原田1, Izumi Hide1,
Norio Sakai1
1Dept. of Mol. and Pharmacol. Neuroscience, Grad. Sch. of Biomed. and Health Sciences, Hiroshima Univ.,
Hiroshima Univ. of Fac. of Med.

2

Copyright © The Japanese Pharmacological Society

2-P1-04 Poster Sessions
The role of synchronous firing on the neural circuit development
Kashima Tetsuhiko, Yuji Ikegaya
Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo

Copyright © The Japanese Pharmacological Society

2-P1-05 Poster Sessions
The subiculum sensitizes retrosplenial cortex layer 2/3 pyramidal neurons
Mengxuan Gao1, Asako Noguchi1, Yuji Ikegaya1,2,3
1Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, 2Inst. Beyond AI, 3Center for Information and
Neural Networks

Copyright © The Japanese Pharmacological Society

2-P1-06 Poster Sessions
Induction of theta phase precession using a neurofeedback system.
Aoki Yuki1, Yuji Ikegaya1,2,3, Takuya Sasaki1,4
1

Lab. of Chem. Pharmcol., Grad. Sch. of Pharmaceut. Sci., The Univ. of Tokyo, 2Inst. for AI and Beyond, 3Center for
Information and Neural Networks, 4Japan Sci. and Tech. Agency, PRESTO

Copyright © The Japanese Pharmacological Society

2-P1-07 Poster Sessions
Urethane anesthesia suppresses hippocampal subthreshold activity andneuronal synchronization.
Yagishita Haruya1, Yuya Nishimura1, Asako Noguchi1, Yu Shikano1, Yuji Ikegaya1,2,3,
Takuya Sasaki1,4
1

Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, 2Institute for AI and Beyond, The University ofTokyo, 3Center for Information and Neural Networks, National Institute of Information and Communications
Technology, 4Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency

Copyright © The Japanese Pharmacological Society

2-P1-08 Poster Sessions
Spike activity of dorso-ventral hippocampus in response to aversive
stimulus
Sakura Okada1, Yuji Ikegaya1,2,3, Takuya Sasaki1,4
1

Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, 2Institute of AI and Beyond, The University ofTokyo, 3Center for Information and Neural Networks, National Institute of Information and Communications
Technology, 4Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency

Copyright © The Japanese Pharmacological Society

2-P1-09 Poster Sessions
Activity of histamine neurons in the tuberomammillary nucleus associatedwithin learning and memory
Nishimura Kyoka, Ayame Kubo, Rintaro Shimizume, Natuko Hitora（Imamura）,
Masabumi Minami, Hiroshi Nomura
Hokkaido Univ.

Copyright © The Japanese Pharmacological Society

2-P1-10 Poster Sessions
The neural projection mechanism from the anterior cingulate cortex to theperiaqueductal gray underlying behavioral selection in a conflict situation
Honshuku Yuki, Ryoki Saito, Takuji Soga, Masabumi Minami, Natsuko HitoraｰImamura
Dept. Pharmacology, Grad. School of Pharmaceutical Sciences, Hokkaido Univ.

Copyright © The Japanese Pharmacological Society

2-P1-11 Poster Sessions
Indispensability of glial glutamate transporters during a neurodevelopmental
period to cognitive behaviors and brain development
Mizuki Uchida1, Norio Ozaki2, Akira Yoshimi1, Yukihiro Noda1
1Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm., 2Dept. Psychiatry, Nagoya Univ.
Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society

2-P1-12 Poster Sessions
Evaluation of cognitive function in diabetic germ-free mice
Hiroyuki Kobayashi1, Hiroyasu Murasawa1, Akiko Pawlak1, Kazutaka Katayama2,
Daisuke Kishigai2, Saki Shimato1, Miki Sugiyama1, Masae Okuyama1, Takahito Imaizumi1,
Nozomu Shimato1, Hiroko Nonomura1, Ryusei Nishiyama1, Takuji Mizuki1, Yasushi Hirasawa1
1

Nihon Bioresearch Inc., 2OrientalBioService Inc.

Copyright © The Japanese Pharmacological Society

2-P1-13 Poster Sessions
The cognitive impairment induced via activation of hypoxia inducible factor-1 alpha signaling pathway
Daisuke Kodama, Yoshiaki Ohi, Akira Haji
Lab. Neuropharmacol., Sch. Pharm. Aichi-Gakuin Univ.

Copyright © The Japanese Pharmacological Society

2-P1-14 Poster Sessions
Microsomal prostaglandin E synthase-1 induced by hemoglobin in microglia
contributes to inflammation and neuronal death
Yuri Ikeda-Matsuo1,2, Norika Yunoki1, Minori Kaji1, Satoshi Uematsu3, Shizuo Akira4,
Tatsuo Takahashi1, Mitsuo Tanabe2
1

Lab. Pharmacol., Fac. Pharmac. Sci., Hokuriku Univ., 2Lab. Pharmacol., Sch. Pharmac. Sci., Kitasato Univ.,
3
Dept. Immunol. Genomics, Osaka City Univ. Grad. Sch. Med., 4Lab. Host Defense, WPI Immunol. Front. Res. Ctr,
Osaka Univ.

Copyright © The Japanese Pharmacological Society

2-P1-15 Poster Sessions
Thrombin increases kynurenine 3-monooxygenase expression in microglia
Masatoshi Ohnishi, Shunpei Tasaka, Mana Furutaguchi, Takuya Shigemasa, Takao Kai,
Yuki Shimizu, Yuui Urabe, Yukino Yano, Atsuko Inoue
Dept. Pharmacotherap. Fukuyama Univ.

Copyright © The Japanese Pharmacological Society

2-P1-16 Poster Sessions
P2Y2 receptor/PYK2 signaling mediates dying cell phagocytosis by microglia
Izumi Hide, Hiroko Shiraki, Mayuka Kumagai, Takuya Maeda, Kana Harada, Shigeru Tanaka,
Norio Sakai
Dept. Mol. Pharmacol. Neurosci., Grad. Sch. Biomed. Health Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society

2-P1-17

Poster Sessions
2+

Extracellular Zn suppress IL-6 secretion from M2/M1 switched microglia
through ZIP zinc transporter
Takaaki Aratake1,2, Youichirou Higashi1, Sou Kedahana1, Yusuke Morishita1, Takahiro Shimizu1,
Shogo Shimizu1, Suo Zou1, Masaki Yamamoto1, Rina Nakamura1, Toshifumi Akizawa1,
Motoaki Saito1
1

Dept. of Pharmacol., Kochi Med. Sci., Kochi Univ., 2JSPS Research Fellow

Copyright © The Japanese Pharmacological Society

2-P1-18 Poster Sessions
LPS decrease KCC2 expression in primary rat cerebral cortex cells and PC-12 cells
Kazuo Tomita1, Sayuri Yamanishi1,3, Kento Igarashi1,2, Yoshikazu Kuwahara1,4, Kohichi Tanaka1,2,5, Jyun-ichi Kitanaka5, Nobue Kitanaka5, Akihiro Kurimasa4, Shoichi Miyawaki3,
Nobuyoshi Nishiyama2, Motohiko Takemura5, Tomoaki Sato1
1

Dept. Applied Pharm., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 2Div. Pharmacol., Dept. Pharm., Sch.
Pharm., Hyogo Univ. Health Sci., 3Dept. Orthodontics and Dentofacial Orthopedics, Grad. Sch. Med. & Dent. Sci.,
Kagoshima Univ, 4Dept. Radiation Biol. Med., Facul. Med, Tohoku Med. Pharm. Univ., 5Dept. Pharmacol., Hyogo
Col. Med.

Copyright © The Japanese Pharmacological Society

2-P1-19 Poster Sessions
Regulation of receptor chaperone molecule RTP4 in neuronal cells by opioid
receptor activation
Wakako Fujita, Jun Aruga
Dept. Med. Pharmacol., Grad. Sch. Biomed. Sci., Nagasaki Univ.

Copyright © The Japanese Pharmacological Society

2-P1-20 Poster Sessions
Regulation of receptor chaperone molecule RTP4 in microglial cells under
the inflammatory stress
Yusuke Kuroiwa1, Wakako Fujita2
1

Dept. Pharmacol. Therap. Innov., Sch. Pharmaceu. Sci., Nagasaki Univ., 2Dept. Med. Pharmacol., Grad. Sch.
Biomed. Sci., Nagasaki Univ.

Copyright © The Japanese Pharmacological Society

2-P1-21 Poster Sessions
p38 MAPK is directly inhibited by PNU-120596, a positive allostericmodulator of α7 nicotinic acetylcholine receptor
Junsuke Uwada
Div. Cell. Signal Transduct., Dept. Biochem., Asahikawa Med. Univ.

Copyright © The Japanese Pharmacological Society

2-P1-22 Poster Sessions
Novel TREK-1 activators suppress neuronal excitability and pain behavior inrodent model.
Kenji Goryo1, Takashi Miyano1, Masahiko Irie1, Rieko Matsumura1, Masako Tanabe1,
Kenta Kagaya1, Shun Saito1, Takehiko Inohana2, Misa Hayashi2, Kuniyoshi Koyachi2,
Junji Kamon1
1

Pharmaceut. Res. Dept., Biol. Res. Lab., Nissan Chemical Corporation, 2Pharmaceut. Res. Dept., Chem. Res. Lab.,
Nissan Chemical Corporation

Copyright © The Japanese Pharmacological Society

2-P1-23 Poster Sessions
Activation of spinal dorsal horn astrocytes by noxious stimulus involves
descending noradrenergic signaling
Riku Kawanabe, Kohei Yoshihara, Makoto Tsuda
Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.

Copyright © The Japanese Pharmacological Society

2-P1-24 Poster Sessions
Neuron-derived ATP promotes paclitaxel-induced HMGB1 release frommacrophages: role of ATP as a neuroimmune mediator in chemotherapyinduced peripheral neuropathy
Risa Domoto, Riki Kamaguchi, Maiko Iemura, Fumiko Sekiguchi, Atsufumi KawabataLab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ.

Copyright © The Japanese Pharmacological Society

2-P1-25 Poster Sessions
Repagermanium hydrolysate suppresses H 2S-dependent Cav3.2 channel
hyperactivity and visceral or somatic pain by trapping sulfide
1

1

1

2

2

Nene Koike , Kaho Sugimoto , Hiroshi Masuda , Yasuhiro Shimada , Katsuyuki Sato ,2
3
4
5
Takashi Nakamura , Hiroaki Yamaguchi , Genzou Tanabe , Shinsuke Marumoto ,11
6
7
Yoshihito Kasanami , Fumiko Sekiguchi , Tsuyako Ohkubo , Shigeru Yoshida ,1Atsufumi Kawabata
1

Lab. Pharmacol. Pathophysiol, Fac. Pharm., Kindai Univ., 2Asai Germanium Res. Inst Co., Ltd., 3Yamagata Univ.
Grad. sch. Med. Sci., 4Lab.Org. Chem., Fac. Pharm., Kindai Univ., 5Joint Res. cent, Kindai Univ., 6Div. Basic Med.
Sci. Fundam. Nurs., Fac. Nurs., Fukuoka Nurs. Coll., 7Dept. Life Sci., Fac. Sci. Engineer., Kindai Univ.

Copyright © The Japanese Pharmacological Society

2-P1-26 Poster Sessions
Macrophage-derived HMGB1 contributes to the accelerated neurite
outgrowth in dorsal root ganglion neurons isolated from the mice subjectedto sciatic nerve injury
Fumiko Sekiguchi1, Yui Nakatake1, Maho Tsubota1, Masahiro Nishibori2, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., 2Dept. Pharmacol., Okayama Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society

2-P1-27 Poster Sessions
The mechanism of the modulation of pain signaling by b-series gangliosides
Shun Watanabe1,2, Motoki Morita1,2, Daichi Kitamura1,2, Misa Oyama1,2, Takashi Iwai1,2,
Mitsuo Tanabe1,2
1Lab. Pharmacology, Sch. Pharm., Kitasato Univ., 2Medicinal Research Lab., Sch. Pharm., Kitasato Univ.

Copyright © The Japanese Pharmacological Society

2-P1-28 Poster Sessions
Study on the Evaluation System of Post-Stroke Pain Model in Rats
Takashi Tashiro, Yoshiyuki Hayashida, Saeko Yoshihara, Masana Kamioka, Ikuo Takahashi,
Seiichi Katayama, Naoyuki Hironaka, Katsuhide Nishi
LSI Medience Corporation

Copyright © The Japanese Pharmacological Society

2-P1-29 Poster Sessions"Quality of Lipid" in the dorsal root ganglion
Shota Yamamoto1, Takao Shimizu1,2, Hideo Shindou1,3
1Department of Lipid Signaling, National Center for Global Health and Medicine, 2Institute of Microbial Chemistry,
The Microbial Chemistry Research Foundation, 3Department of Lipid Science, Graduate School of Medicine, The
University of Tokyo

Copyright © The Japanese Pharmacological Society

2-P1-30 Poster Sessions
SSRI improves a long-lasting decrease in sociability with attenuation ofmorphological changes in hippocampal microglial cells in tumor-resectedmice
Yusuke Onaka1, Yui Tanaka1, Yukinori Nakashima1, Taro Yamaguchi1, Masanori Yoneyama1,
Norihito Shintani2, Hitoshi Hashimoto2,3,4,5,6
1

Lab. Pharmacol., Fac. Pharmaceut. Sci., Setsunan Univ., 2Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceutic.
Sci., Osaka Univ., 3United Grad Sch. Child Develop., Osaka Univ., 4Instit. for Datability Sci., Osaka Univ., 5Dept.
Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ., 6Instit. for Open and Transdisciplinary Res. Initiatives,
Osaka Univ.

Copyright © The Japanese Pharmacological Society

2-P1-31 Poster Sessions
Effects of intracerebroventricular injection of anti- and pro-inflammatory
mediators on depression-like behaviors.
Takahisa Otsuka, Hiroe Suzuki, Natsuko Hitora-Imamura, Masabumi Minami
Department Pharmacology., Graduate School of Life Science, Hokkaido University

Copyright © The Japanese Pharmacological Society

2-P1-32 Poster Sessions
The anti-alcoholism drug disulfiram produces anxiolytic effects in mice.
Nagayama Yoshifumi1, Daisuke Yamada1, Yuya Terashima2, Kosyo Makino3,
Yoshino Takahashi3, Yoshitake Sano4, Etsuko Toda2, Misaki Ohashi1, Toshinori Yoshioka1,
Kotaro Okano1, Tomoki Omata1, Hideyo Takahashi3, Kouji Matsushima2, Akiyoshi Saitoh1
1

Lab Pharmacol., Fac Pharm Sci, Tokyo Univ of Science., 2Lab Mol. Reg. Dis., RIBS, Tokyo Univ of Science., 3Lab
Med.Chem., Tokyo Univ of Science., 4Lab Dept. Appl. Biol. Sci., Tokyo Univ of Science.

Copyright © The Japanese Pharmacological Society

2-P1-33 Poster Sessions
Antidepressant-like effect of captopril via hippocampal angiotensin (1-7) /MAS1 pathway in olfactory bulbectomized mice.
Miharu Wakou, Osamu Nakagawasai, Taisei Koyama, Takayo Odaira, Wakana Sakuma,
Ryota Yamagata, Wataru Nemoto, Koichi Tan-No
Dept. Pharmacol., Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Uni.

Copyright © The Japanese Pharmacological Society

2-P1-34 Poster Sessions
Possible change in transcriptional regulation of 5-HT1A receptor in the
midbrain of stress-maladaptive mice
1,2

1

2

2

1,3

Hiroko Miyagishi , Minoru Tsuji , Yasuhiro Kosuge , Kumiko Ishige , Hiroshi Takeda
1Dept. Pharmacol., Sch. Pharm., International Univ. Health and Welfare, 2Lab. Pharmacol., Sch. Pharm., Nihon
Univ., 3Dept. Pharmacol., Sch. Pharm. at Fukuoka, International Univ. Health and Welfare

Copyright © The Japanese Pharmacological Society

2-P1-35 Poster Sessions
Analysis of mRNA expression levels for cyclooxygenase isozymes andprostanoid synthases in the rat hypothalamic paraventricular
nucleus after restraint stressYuqiu Wu1, Naoko Yamaguchi1, Kazuhiro Yoshikawa2, Shoshiro Okada1
1

Dept Pharmacol, Sch Med, Aichi Med Univ, Aichi, Japan, 2Div Res Creation & Biobank, Res Creation Support Ctr,
Aichi Med Univ, Aichi, Japan

Copyright © The Japanese Pharmacological Society

2-P1-36 Poster Sessions
Social cognitive improvement via activation of the hippocampal α7 nicotinic
acetylcholine receptor in stressed mice
Kana Hosoi1, Mizuki Uchida1, Erika Ota1, Akira Yoshimi1, Norio Ozaki2, Yukihiro Noda1
1Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm., 2Dept. Psychiatry, Nagoya Univ.
Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society

2-P1-37 Poster Sessions
Kamishoyosan reduces aggressive behavior of isolated-reared mice toward
inanimate objects and involvement of estrogen receptor β
Kento Igarashi1,2, Toshiko Kuchiiwa3, Satoshi Kuchiiwa4, Kazuo Tomita1,2, Koh-ichi Tanaka1,2,
Nobue Kitanaka5, Junichi Kitanaka5, Nobuyoshi Nishiyama2, Motohiko Takemura5,
Tomoaki Sato1
1

Lab. of applied pharmacology, Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 2Div. Pharmacol., Dept. Pharm.,
Sch. Pharm., Hyogo Univ. Health Sci., 3Dept. of Clinical Pshychol., Grad. Sch. Human Sci., Kagoshima Immaculate
Heart Univ., 4Dept. Neuroanatomy, Field of Neurol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 5Dept.
Pharmacol., Hyogo Col. Med.

Copyright © The Japanese Pharmacological Society

2-P1-38 Poster Sessions
Evaluation of antipsychotic properties of M4 muscarinic acetylcholine
receptor agonists in mice
1,2

1

1

1

1

Yumika Toyoshima , Motoki Nakamura , Emi Yoshida , Chifuyu Ohashi , Konosuke Hirose ,
1
1
1
1
2
Yuto Ishizaki , Yoshihiro Nakamura , Mei Higaki , Saki Shimizu , Takaaki Sumiyoshi ,1
Yukihiro Ohno
1

Dept. Pharmacol., Osaka Univ. Pharm. Sci., 2Dept. Life Sci. and Biotech., Kansai Univ.

Copyright © The Japanese Pharmacological Society

2-P1-39 Poster Sessions
Adolescent social isolaion induced dissociable effects on synaptictransmissions in medial and lateral OFC-BLA pathways
Hiroshi Kuniishi1,2, Masayuki Sekiguchi2, Mitsuhiko Yamada1
1

Dept Neuropsychopharmacoly, National Institute of Mental Health, National Center of Neurology and Psychiatry,
Dept Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology andPsychiatry2

Copyright © The Japanese Pharmacological Society

2-P1-40 Poster Sessions
A novel bipolar syndrome animal model via reduction of Teneurin-4, theprotein encoded by ODZ4, in the prefrontal cortex of mice
Takashi Asano1, Kazuki Tokoro1, Naotaka Izuo1, Fumitaka Nakano1, Masaya Miyashita1, Shinichi Muramatsu2,3, Atsumi Nitta1
1

Department of Pharmaceutical Therapy and Neuropharmacology, The University of Toyama, Japan, 2Departmentof Neurology, Jichi Medical University, Japan., 3Center for Gene and Cell Therapy, Institute of Medical Science,
The University of Tokyo, Japan.

Copyright © The Japanese Pharmacological Society

2-P1-41 Poster Sessions
Neural ensembles in the insular cortex encode social exploration
Masaaki Sato1,2, Isamu Miura3, Eric Overton2, Nobuo Kunori4, Junichi Nakai5,
Takakazu Kawamata3, Nobuhiro Nakai2,6, Toru Takumi2,61

Dept Neuropharmacol, Hokkaido Univ Grad Sch Med, 2RIKEN CBS, 3Dept Neurosurg, Tokyo Women's Med Univ,
AIST, 5Div Oral Physiol, Tohoku Univ Grad Sch Dent, 6Dept Physiol Cell Biol, Kobe Univ Sch Med

4

Copyright © The Japanese Pharmacological Society

2-P1-42 Poster Sessions
Development of epigenome therapeutic agents and treatments to improve
cognitive impairments in schizophrenia
Fukuda Mayu, Jun Mukai
Tsukuba Univ. Ctr. Neurosci.

Copyright © The Japanese Pharmacological Society

2-P1-43 Poster Sessions
Enriched environment reverts decreased sociability in prenatal folate
deficiency mice
Misato Yoshikawa, Hiroaki Aso, Masahiko Watanabe, Katsuya Suemaru
Dept. Public Health Shujitsu Univ.

Copyright © The Japanese Pharmacological Society

2-P1-44 Poster Sessions
Reduced expression of NMDA receptors (NR2A and NR2B) in the
hippocampus of WD repeat domain 3 gene hetero knockout mice
Kobayashi Momoko, Hiroki Furuie, Hideki Miwa, Misa Yamada, Mitsuhiko Yamada
Dept. of Neuropsychopharmacology, Natl. Inst. of Mental Health, Natl. Ctr. of Neurology and Psychiatry

Copyright © The Japanese Pharmacological Society

2-P2-01 Poster Sessions
The mechanism of serotonin-induced constriction in 2K1C hypertensive rat
mesenteric arteries
Yuka Terada, Manami Tani, Miku Komatsu, Katsutoshi Yayama
Lab. Cardiovasc. Pharmacol. Fac. Pharma. Sci. Kobe Gakuin Univ.

Copyright © The Japanese Pharmacological Society

2-P2-02 Poster Sessions
Pathophysiological roles of excitation-transcription coupling in vascularsmooth muscle cells.
Yoshiaki Suzuki, Takumi Ozawa, Nanami Nakajima, Yuji Imaizumi, Hisao Yamamura
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society

2-P2-03 Poster Sessions
Effects of pressure stress on MAPK activation induced by interleukin-1β andangiotensin II in cultured human pulmonary artery smooth muscle cells.
Sachiko Hiraide, Takuji Machida, Shota Takihana, Mikoto Ohshita, Kenji Iizuka
Dept. of Pharmacol. Sci., Schl. of Pharmaceut. Sci., Health Sci. Univ. of Hokkaido

Copyright © The Japanese Pharmacological Society

2-P2-04 Poster Sessions
Fingolimod ameliorates the development of PAH in monocrotaline-induced
pulmonary hypertensive rats
Moe Fujiwara1, Aya Yamamura2, Yoshiaki Suzuki1, Hisao Yamamura1
1Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2Dept. Physiol., Aichi Med. Univ.

Copyright © The Japanese Pharmacological Society

2-P2-05 Poster Sessions
Involvement of Mitofusin2 on functional interaction between SR andmitochondria in rat aortic smooth muscle cells
Sou Inagaki, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura
Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., Nagoya, Japan

Copyright © The Japanese Pharmacological Society

2-P2-06 Poster Sessions
Possible selective inhibitory effects of docosahexaenoic acid (DHA) on
U44619- and prostaglandin F2α (PGF2α)-induced contractions of coronary andcerebral arteries isolated from the pig.
Kento Yoshioka, Kohhei Uemura, Akina Yamaguchi, Guanghan Ou, Keyue Xu, Fumiko Yamaki,
Keisuke Obara, Yoshio Tanaka
Dept. Chem. Pharmacol., Facul. Pharmaceut. Sci., Toho Univ.

Copyright © The Japanese Pharmacological Society

2-P2-07

Poster Sessions+/

2+

The contribution of Na Ca exchanger 1 in pulmonary arterial hypertension
in mice.
Satomi Kita1,2, Hideaki Tagashira2, Asahi Nagata2, Tomo Kita2, Takahiro Iwamoto2
1

Dept. Pharmacol., Facul. Pharmaceut. Sci., Tokushima Bunri Univ., 2Dept. Pharmacol., Facul. Med., Fukuoka
Univ.

Copyright © The Japanese Pharmacological Society

2-P2-08 Poster Sessions
Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin
II-induced hypertension model mice
Misaki Yamamoto1, Fumi Takahashi-Yanaga2, Toshiyuki Sasaguri1
1

Dept Clin Pharmacol, Faculty Med Sci, Kyushu Univ, 2Dept Pharmacol, Faculty Med, Univ Occup Environ Health

Copyright © The Japanese Pharmacological Society

2-P2-09

Poster Sessions+

Functional expression of two-pore domain K channels in pulmonary arterial
hypertension
Natsumi Shima1, Aya Yamamura2, Yoshiaki Suzuki1, Hisao Yamamura1
1Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceutic. Sci., Nagoya City Univ., 2Dept. Physiol, Aichi Medical
Univ.

Copyright © The Japanese Pharmacological Society

2-P2-10 Poster Sessions
Relaxation of rat pulmonary arterial smooth muscles by pine resin-derived
compounds
Ishida Masashi, Suzuki Yoshiaki, Hisao Yamamura
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society

2-P2-11 Poster Sessions
Junctophilin-2 promotes the proliferation of vascular smooth muscle cells
Shibahara Emina
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society

2-P2-12 Poster Sessions
Losartan, angiotensin II type 1 receptor blocker improves prostatic
hyperplasia in spontaneously hypertensive rats
Shogo Shimizu1, Yoshiki Nagao1, Tamaki Kataoka1,2, Shiho Kamada1,2, Reina Okamoto1,2,Takahiro Shimizu1, Youichirou Higashi1, Takaaki Aratake1,3, Suo Zou1, Masaki Yamamoto1,
Motoaki Saito1
1

Department of Pharmacology, Kochi Medical School, Kochi University, 2Center for Innovative and Translational
Medicine, Kochi Medical School, Kochi University, 3Research Fellow of Japan Society for the Promotion of Science

Copyright © The Japanese Pharmacological Society

2-P2-13 Poster Sessions
Eukaryotic elongation factor 2 kinase inhibitor, A484954 induces diuretic
effect in spontaneously hypertensive rats
Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society

2-P2-14 Poster Sessions
Pleiotropic effects of erythropoietin on renal and aortic injury in sucroseinduced insulin resistant rats
Hiroe Toba, Yota Kaino, Satoka Zaizen, Momoyo Nishikawa, Akihiro Yamaoka, Miyuki Kobara,
Tetsuo Nakata
Dept. Clin. Pharmacol.

Copyright © The Japanese Pharmacological Society

2-P2-15 Poster Sessions
Repeated ischemia/reperfusion before contralateral nephrectomy leads toacceleration of AKI to CKD progression in rats
Shuhei Kobuchi
Dept. Pharm., Pharmacol., Hyogo Univ. Health Sci.

Copyright © The Japanese Pharmacological Society

2-P2-16 Poster Sessions
Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury inrats
Takaomi Shimokawa1, Masayo Yamagata1, Kohei Hayashi1, Shuhei Tomita2, Kozo Yoneda1
1

Lab. Clin. Pharmacol., Fac. Pharm., Osaka Ohtani Univ., 2Dept. Pharmacol., Fac. Med., Osaka City Univ.

Copyright © The Japanese Pharmacological Society

2-P2-17 Poster Sessions
Effects of agmatine and pirfenidone on renal fibrosis after acute kidney
injuryTakahiro Sugiura, Shoko Otsu, Keita Owaki, Mana Naito, Shiori Murase, Yasushi Hirasawa,
Takahiko Nagase
Nihon Bioresearch Inc.

Copyright © The Japanese Pharmacological Society

2-P2-18 Poster Sessions
Effect of hydrogen sulfide on bladder of cyclophosphamide-induced cystitis
in rats
Suo Zou1, Takahiro Shimizu1, Shogo Shimizu1, Hideaki Ono1,2, Yohei Shimizu1,2, Yurika Hata1,2,
Masaki Yamamoto1, Takaaki Aratake1,3, Youichirou Higashi1, Motoaki Saito1
1

Dept. of Pharmacol., Kochi Med. Sci., Kochi Univ., 2Ctr. for Innov. and Transl. Med., Kochi Univ.,3Res. Flw. of
Jpn. Soc. for the Promo. of Sci.

Copyright © The Japanese Pharmacological Society

2-P2-19 Poster Sessions
Deep neural network approach for understanding water-taking behavior after
Tolvaptan
Hiroaki Kaminaga, Yuta Mochimaru, Morio Azuma, Hiroyoshi Tsuchiya, Taka-aki Koshimizu
Jichi Medical Univ. Div. Mol. Pharmacol.

Copyright © The Japanese Pharmacological Society

2-P2-20 Poster Sessions
Brain α7 nicotinic receptor stimulation inhibits the rat micturition reflex via
brain GABAA receptors
1,2

1

1,2

1

1

Yohei Shimizu , Takahiro Shimizu , Hideaki Ono , Suo Zou , Masaki Yamamoto ,
1,2
1,3
1
1
1
Yurika Hata , Takaaki Aratake , Shogo Shimizu , Youichirou Higashi , Motoaki Saito
1

Dept. of Pharmacol., Kochi Med. Sch., Kochi Univ., 2Ctr. Innov. and Translational Med., Kochi Med. Sch., Kochi
Univ., 3Research Fellow of Japan Society for the Promotion of Science

Copyright © The Japanese Pharmacological Society

2-P2-21 Poster Sessions
Involvement of AGN-1 protein, which binds to protein phosphatase 6, incentrosome formation during the process of cell division
Suzuki Nana, Hinako Osada, Ryoji Kojima
Lab. of Anal. Pharmacol. Fac. of Pharm. Meijo Univ.

Copyright © The Japanese Pharmacological Society

2-P2-22 Poster Sessions
Prenatal glucocorticoid administration accelerates glomeruli and renal
tubules development in the fetal rats.
Yuko Takeba, Tsukasa Kobayashi, Masanori Ootaki, Yuki Ohta, Kiesuke Kida,
Minoru Watanabe, Taroh Iiri, Naoki Matsumoto
Dept. Pharmacol. St. Marianna Unv Sch Med

Copyright © The Japanese Pharmacological Society

2-P2-23 Poster Sessions
The production and role of hydrogen sulfide and hydrogen polysulfides inmammalian cells
Norihiro Shibuya, Yuka Kimura, Hideo Kimura
Sanyo-Onoda City University

Copyright © The Japanese Pharmacological Society

2-P2-24 Poster Sessions
AGEs synergistically potentiated the LPS-HMGB1-induced proinflammatory
response through their direct interactions
Shuji Mori1, Masahiro Watanabe1, Hidenori Wake2, Keyue Liu3, Kiyoshi Teshigawara3,
Hideo Takahashi2, Masahiro Nishibori3, Takao Toyomura1
1

Sch Pharm, Shujitsu Univ, 2Fac Med, Kindai Univ, 3Grad Sch Med Dent & Pharm Sci, Okayama Univ

Copyright © The Japanese Pharmacological Society

2-P2-25 Poster Sessions
Evaluation and comparison of two of LPS-induced acute lung injury (ARI)
mice models
Ushijima Souta, Sayuri Nishikawa, Hideaki Kamaga, Kousuke Morizumi, Seiichi Katayama,
Katsuhide Nishi
Pharmacology Department, Nonclinical Research Center, Drug Development Service Segment, LSI Medience
Corporation

Copyright © The Japanese Pharmacological Society

2-P2-26
Withdraw

Poster Sessions

1 2, Sakurajyuji medical corporation

Copyright © The Japanese Pharmacological Society

2-P2-27 Poster Sessions
Effects of dasatinib on airway inflammation induced by lipopolysaccharide
and/or ovalbumin
Yuki Nishimoto1, Yukiko Eguchi1, Yuka Koizumi1, Nanaka Ito1, Naoki Ishikawa1, Minami Saito1,
Genki Kimura1, Kazuhiro Ito2, Yasuo Kizawa1
1

Lab. Physiol. & Anat., Nihon Univ. Sch. Pharmacy, 2Imperial College London, UK

Copyright © The Japanese Pharmacological Society

2-P2-28 Poster Sessions
Thioredoxin-albumin fusion protein prevents urban aerosol-induced lunginjuryKen-ichiro Tanaka1, Maho Kubota1, Mikako Shimoda1, Mayumi Ikeda2, Yu Ishima2,
Masahiro Kawahara1
1

Musashino Univ., 2Tokushima Univ.

Copyright © The Japanese Pharmacological Society

2-P2-29 Poster Sessions
Pharmacological studies on pulmonary fibrosis model induced byintratracheal instillation of bleomycin in miceJun-ichi Fuchikami1, Maki Takahashi1, Yoshiyuki Suzuki1, Atsuko Ichikawa1, Yasuki Akie1,
Hiroyuki Nakamura2
1

CMIC Pharma Science Co., Ltd., 2Lab. of Chem. Pharmac., Grad. Sch. of Pharmaceut. Sci., Chiba Univ.

Copyright © The Japanese Pharmacological Society

2-P2-30 Poster Sessions
Generation of ACE2-Expressing Airway and Alveolar Epithelial Cells from
Human Induced Pluripotent Stem Cells
Tsuji Kayoko, Yasunari Kanda
Div. Pharmacol, NIHS

Copyright © The Japanese Pharmacological Society

2-P2-31 Poster Sessions
Expression of glucocorticoid receptors (GRs) in eosinophils derived fromsteroid-resistant asthma model of mice
Kennosuke Hashimoto, Maki Matsuo, Ayaka Mori, Hayato Shimora, Momo Utsumi, Rina Ano,
Masaya Matsuda, Kazuyuki Kitatani, Takeshi NabeLab. of Immunopharmacol., Fac. of Pharm. Sci., Setsunan Univ., Osaka, Japan

Copyright © The Japanese Pharmacological Society

2-P2-32 Poster Sessions
Characterization of Staphylococcus aureus derived from atopic dermatitis
using a cell imaging system.
Ryu Miyake1,2, Kazumasa Iwamoto2, Motoyuki Sugai3, Michihiro Hide2, Norio Sakai1
1Dept. of Mol. Pharmacol Neurosci., Grad. Sch. of Biomed and Health Sci., Hiroshima Univ., 2Dept. of
Dermatology, Grad. Sch. of Biomed and Health Sci., Hiroshima Univ., 3Antimicrobial Resistance Res. Ctr., Nat.
Insti. of Infectious Diseases

Copyright © The Japanese Pharmacological Society

2-P2-33 Poster Sessions
Functional role of NCX1 in brown adipose tissue thermogenesis
Tomo Kita1, Hideaki Tagashira1, Takayuki Nemoto1, Satomi Kita1,2, Takahiro Iwamoto1
1

Dept. Pharmacol. Fac. Med. Fukuoka Univ., 2Dept. Pharmacol. Fac. Pharmaceut. Sci. Tokushima Bunri Univ.

Copyright © The Japanese Pharmacological Society

2-P2-34 Poster Sessions
The role of microsomal Prostaglandin E syntase-1 (mPGES-1)/PGE2 axis
facilitates granulation tissue formation
1,2

1

1

1

1

3

Tetsuya Hyodo , Hideki Amano , Yoshiya Ito , Kanako Hosono , Ko Hatanaka , Koji Eshima ,4
52
Satoshi Uematsu , Shizuo Akira , Akira Takeda
1Dept. of Pharmacol., Kitasato Univ. Sch. of Med., 2Dept. of Plast. and Reconst. Surg., Kitasato Univ. Sch. of Med.,
Dept. of Immunol., Kitasato Univ. Sch. of Med., 4Dept. of Immunol. and Geno., Osaka City Univ. Grad. Sch. ofMed., 5Lab. of Host Defense, WPI Immunol. Frontier Res. Ctr. (IFReC), Osaka Univ.
3

Copyright © The Japanese Pharmacological Society

2-P2-35 Poster Sessions
Saireito, a traditional Chinese medicine, suppressed photodamage andreduction of lymphatic vessel density in UVB-irradiated skin.
Manami Oyama, Kenta Murata, Nina Fujita, Ryuji Takahashi
Kampo Res. Lab., Kracie Pharma, Ltd.

Copyright © The Japanese Pharmacological Society

2-P2-36 Poster Sessions
Oral administration of Jumihaidokuto inhibits UVB-induced skin damage andprostaglandin E2 production in HR-1 hairless mice
Murata Kenta, Manami Oyama, Nina Fujita, Ryuji Talahashi
Kracie Pharma Ltd. Kampo research Lab

Copyright © The Japanese Pharmacological Society

2-P2-37 Poster Sessions
Role of translation factors in proliferation of breast cancer stem cells.
Naoya Hirata, Shigeru Yamada, Yasunari Kanda
Div. Pharmacol. NIHS

Copyright © The Japanese Pharmacological Society

2-P2-38 Poster Sessions
Elevated serum cholesterol levels after the discontinuation of imatinib inpatients with chronic myeloid leukemia
Masamitsu Takaba1, Takaaki Ono1, Takayuki Iwaki2, Kazuo Umemura2
1

Division of Hematology, Hamamatsu University School of Medicine, 2Department of Pharmacology, Hamamatsu
University School of Medicine

Copyright © The Japanese Pharmacological Society

2-P2-39 Poster Sessions
Healing effects of rebamipide on oral stomatitis in 5-fluorouracil-untreated
and -treated Golden Syrian hamsters
Mitsutoshi Satoh1, Takuya Shiraishi1, Kousei Sekikawa1, Miku Motohashi1, Hiroyuki Tanaka2,
Yayoi Kawano3, Takehisa Hanawa3
1

Dept. Toxicol. Pharmacol., Pharmaceut. Sci., Meiji Pharmaceut. Univ., 2Dept. Practical Pharm., Pharmaceut. Sci.,
Toho Univ., 3Lab. Preform. Design, Pharmaceut. Sci., Tokyo Univ. of Sci.

Copyright © The Japanese Pharmacological Society

2-P2-40 Poster Sessions
Timosaponin AIII disturbs morphological plasticity and migration by
suppressing membrane dynamics.
Takeshi Terabayashi1, Katsuhiro Hanada2, Shigeru Matsuoka3, Takahiro Akamine1,
Toshimasa Ishizaki1
1

Dept. Pharmacol., Fac. Med., Oita Univ., 2Clin. Eng. Res. Ctr., Fac. Med., Oita Univ., 3Dept. Cli. Pharmcol &Therap., Fac. Med., Oita Univ.

Copyright © The Japanese Pharmacological Society

2-P2-41 Poster Sessions
O-GlcNAcylation-mediated regulation of FOXM1 expression through its
ubiquitination in a human gastric adenocarcinoma cell line, NUGC-3
Kazumasa Moriwaki1, Yasuhiro Ueda2, Toshihisa Taheuchi2, Kazuhide Higuchi2, Michio Asahi11Dept. Pharmacol., Fac. Med., Osaka Med. College, 2Dept. Int. Med. II, Fac. Med., Osaka Med. College

Copyright © The Japanese Pharmacological Society

2-P2-42 Poster Sessions
Genome-wide analysis of DNA methylation identifies apoptosis-related gene
UQCRH in renal cancer
Ehata Shogo1,2, Kosuke Miyakuni1, Jun Nishida1, Kohei Miyazono1
1

Dept. Mol. Pathol., Grad. Sch. Med., Univ. Tokyo, 2Environ. Sci. Ctr., Univ. Tokyo

Copyright © The Japanese Pharmacological Society

2-P2-43 Poster Sessions
The migration inhibitory effect of anti-collapsin response mediator protein 2
antibody on the renal cell carcinoma
Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami
Fac. Pharmaceut. Sci., Himeji Dokkyo Univ.

Copyright © The Japanese Pharmacological Society

2-P2-44 Poster Sessions
Differentiation-inducing factor-1 inhibits growth and metastasis of triple
negative breast cancer cells through AMPK-mediated inhibition of mTORC1S6K signaling pathway
Fumi Tetsuo, Masaki Arioka, Koichi Miura, Sasaguri Toshiyuki
Kyushu Univ. Dept. of Clinical Pharmacol.

Copyright © The Japanese Pharmacological Society

2-P2-45 Poster Sessions
Human H1R may contribute to the colorectal cancer metastasis
Matsumoto Rei1, Kaori Ueki1, Yuta Masuda1, Masato Mashimo2, Keijo Fukushima1,
Hiromichi Fujino1
1

Pharmacol. Life Sci. Fac. Pharmaceut. Sci. Tokushima Univ., 2Pharmacol. Fac. Pharmaceut. Sci. Doshisha
Women's Coll. Liberal Arts

Copyright © The Japanese Pharmacological Society

2-P2-46 Poster Sessions
The anti-cancer effect of PGD2 may result from the biased activity on EP4
receptor.
1

1

1

1

2

Takano Harumi , Kanaho Senoo , Mayu Yamashita , Yumi Araki , John W. Regan ,1
1
Keijo Fukushima , Hiromichi Fujino
1

Pharmacol. Life Sci. Fac. Pharmaceut. Sci. Tokushima Univ., 2Pharmcol/Toxicol. Coll. Pharm. Univ of Arizona

Copyright © The Japanese Pharmacological Society