1-O-B1-1 Oral Sessions
Possible Involvement of PACAP-PAC1 Receptor Signaling System to ItchSensation in Mice.
Ichiro Takasaki1, Sho Kato1, Ryuta Ikeda1, Mayuko Murata1, Hiroki Saito2, Yuki Kambe2,
Hiroaki Gouda3, Takuya Okada4, Naoki Toyooka4, Atsuro Miyata2, Takashi Kurihara2
1

Dept. Pharmacol., Grad. Sch. Sci. Eng., Univ. Toyama, 2Dept. Pharmacol., Grad. Sch. Med. Dent., Kagoshima
Univ., 3Dept. Analytical and Physical Chem., Sch. Pharmacy., Showa Univ., 4Dept. Bio-func. Mol. Eng., Grad. Sch.
Sci. Eng., Univ. Toyama

Copyright © The Japanese Pharmacological Society1-O-B1-2 Oral Sessions
Role of MrgprA3-expressing primary sensory neurons in itch responses in
atopic dermatitis model mice
Masanori Fujii, Kyoko Fujii, Ryosuke Miyagawa, Satoshi Tanaka
Dept. Pharmacol., Kyoto Pharm. Univ.

Copyright © The Japanese Pharmacological Society1-O-B1-3 Oral Sessions
Involvement in serotonin receptor subtypes on spontaneous itch-related
behavior in mice with atopy-like dermatitis
Tsugunobu Andoh1,2, Takeshi Osaki2, Daisuke Uta2, Yasushi Kuraishi3, Toshiaki Kume2
1

Dept. Pharmacol. Pathophysiol., College Pharm., Kinjo Gakuin Univ., 2Dept. Applied Pharmacol., Sch. Med.
Pharm. Sci., Univ. Toyama, 3Wakayama Med. Univ.

Copyright © The Japanese Pharmacological Society1-O-B1-4 Oral Sessions
Evaluation of the anti-inflammatory and anti-pruritic responses of fish oil ina mouse model of dermatitis
Fukuyama Tomoki1, Chiharu Hayakawa1, Masaharu Kiyosue2
1

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University,2Oriental Yeast Co.,Ltd.

Copyright © The Japanese Pharmacological Society1-O-B2-1 Oral Sessions
Histamine activation of periaqueductal grey matter and somatosensory
cortex exerts an antinociceptive effect in mechanical allodynia.
Mei Yu1, Takeo Yoshikawa1, Fumito Naganuma2, Kazuhiko Yanai11Dept Pharmacol. Sch Med. Tohoku Univ., 2Div Pharmacol. Fac Med. Tohoku Med and Pharmaceut Univ.

Copyright © The Japanese Pharmacological Society1-O-B2-2 Oral Sessions
A thrombin inhibitor aggravates HMGB1-dependent colonic and bladder
pain: Role of the thrombomodulin/thrombin system in visceral pain
modulation
Ayumu Yamagata1, Kazuki Matsui1, Maho Tsubota1, Masahiro Nishibori2, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., 2Dept. Pharmacol., Okayama Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society1-O-B2-3 Oral Sessions
Exacerbation of paclitaxel-induced peripheral neuropathy and HMGB1induced allodynia in ovariectomized mice
Ayano Kanto1, Shiori Hiramoto1, Maho Tsubota1, Hiroaki Matsunaga1, Tomoyoshi Miyamoto1,2,
Yuichi Koizumi2, Masahiro Nishibori3, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., 2Dept. Pharm., Seichokai Fuchu Hospital, 3Dept.
Pharmacol., Okayama Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society1-O-B2-4 Oral Sessions
Sex-dependent suppressive effects of PLX3397, a microglial inhibitor, on
nerve injury-induced neuropathic pain in mice
Norikazu Kiguchi1, Kentaro Suzuki2
1

Dept. Pharmacol., Sch. Med., Wakayama Med. Univ., 2Dept. Development. Genet., Inst. Adv. Med., WakayamaMed. Univ.

Copyright © The Japanese Pharmacological Society1-O-B3-1 Oral Sessions
Sex-dependent pain-regulatory effects of spinal microglia using Gi / Gq
DREADD systems in mice
Fumihiro Saika, Norikazu Kiguchi, Shinsuke Matsuzaki, Tomoe Nishitani-Nakamura
Dept. Pharmacol. Wakayama Med Univ.

Copyright © The Japanese Pharmacological Society1-O-B3-2 Oral Sessions
Astrocytic histamine N-methyltransferase controls locomotor activity andvigilance state
Rina Otsuka1, Fumito Naganuma2, Yuki Sato1, Yuna Takahashi1, Kazuhiko Yanai1,
Takeo Yoshikawa1
1

Dept. Pharmacol., Grad. Sch. Med., Tohoku Univ., 2Div. Pharmacol., Fac. Med., Tohoku Med. Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society1-O-B3-3 Oral Sessions
Astrocytic mGluR5 controls microglial phagocytosis in the critical period,
which fates a lifelong cortical circuits
Yosuke Danjo1, Youichi Shinozaki1,2, Parajuli Bijay1,2, Ken-Ichi Dewa3, Yuto Kubota1,
Takahiro Segawa4, Eiji Shigetomi1,2, Koizumi Schuichi1,21Dept Neuropharmacol, Interdiscip Grad Sch Med, Univ Yamanashi,, 2Yamanashi Interdiscipinary Brain-Immune
Research Center,, 3Dept Biochem and Cell Biol, Natl Inst Neurosci, NCNP,, 4Cent Life Sci Res., Univ. Yamanashi,

Copyright © The Japanese Pharmacological Society1-O-B3-4 Oral Sessions
Positive effect of microglia repopulation on the Alexander disease
pathology, the primary astrocyte disease
Kenji Kobayashi1, Eiji Shigetomi1, Bijay Parajuli1, Yuto Kubota1, Kozo Saito1, Kenji Tanaka2,
Kazuhiro Ikenaka3, Schuichi Koizumi1
1Dept Neuropharmacol, Interdiscipl Grad Sch Med, Univ Yamanashi, 2Dept Neuropsych, Keio Univ Sch Med., 3Div
Neurobiol and Bioinfo, NIPS

Copyright © The Japanese Pharmacological Society1-O-B3-5 Oral Sessions
Implication of glutamine-glutamate metabolic change in astrocyte via
cGAMP transmitted by metastatic cancer cells
Hiromi Sato1, Toya Okawa1, Kurumi Hara1, Kyoko Goto1, Moe Kikuchi1, Hiroki Tanaka2,
Daiki Shirane2, Takuma Yamakawa2, Hidetaka Akita2, Hiroto Hatakeyama1, Akihiro Hisaka1
1

Clinical Pharmacology & Pharmacometrics, Grad. Sch. Pharmaceut. Sci., Chiba Univ., 2Design and Drug
Disposition, Grad. Sch. Pharmaceut. Sci., Chiba Univ.

Copyright © The Japanese Pharmacological Society1-O-C1-1 Oral Sessions
Establishment of meteoropathy model mice
Yuki Kurauchi1,2, Risako Tanaka2, Sumika Ryu2, Makito Haruta3, Kiyotaka Sasagawa3,
Takahiro Seki1,2, Jun Ohta3, Hiroshi Katsuki1,21Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci, Kumamoto Univ, 2Dept Chemico-Pharmacol Sci, Sch Pharm,
Kumamoto Univ, 3Division of Materials Science, Graduate School of Science and Technology, Nara Institute of
Science and Technology

Copyright © The Japanese Pharmacological Society1-O-C1-2 Oral Sessions
Protective effects of protein SUMOylation on BBB permeability intherapeutic hypothermia for ischemic brain injury
Tanaka Yuta, Mayuko Monden, Masatomo Watanabe, Yutaka Tamura
Dept. Pharmacol., Fac. Pharm. & Pharmaceut. Sci., Fukuyama Univ.

Copyright © The Japanese Pharmacological Society1-O-C1-3 Oral Sessions
Roles of DNA methylation in neuronal cell death after ischemic injury
Mayumi Asada1, Hideki Hayashi1, Kenjiro Murakami1, Kento Kikuiri1, Ryotaro Kaneko1, Bo Yuan2,
Norio Takagi1
1Dept. Appl. Biochem., Sch. Pharm., Tokyo Univ. Pharm. and Life Sci., 2Lab. Pharmacol., Fac. Pharm. andPharmaceut. Sci., Sch. Pharm., Josai Univ.

Copyright © The Japanese Pharmacological Society1-O-C1-4 Oral Sessions
The efficacy and safety of a laser thrombolytic system in an animal
thrombosis model
Yuji Matsumoto1, Daisuke Yamashita2, Yoshiyuki Shimizu2, Yohei Takata2, Tsuyoshi Kosugi2,
Yoshinori Tamaoki2, Hiroyuki Okada2, Teiji Nakayama3, Kazuo Umemura1
1

Dep. Pharmacol., Hamamatsu Univ. Sch. Med., 2Hamamatsu Photonics K.K., 3Dep. Neurosurg., Hamamatsu
Medical Center

Copyright © The Japanese Pharmacological Society1-O-C2-1 Oral Sessions
Prenatal hypoxic stress caused the decrease of astrocytes in theneurodevelopmental disorder-related region of rat brain
Kentaro Tokudome1, Masaaki Ueki1,2, Takehiro Yamaguchi1, Shinji Matsunaga1, Shuhei Tomita1
1

Dept. Pharmacol., Grad. Sch. Med., Osaka City Univ., 2Dep. Anesthesiol., Nishiwaki Municipal Hospital

Copyright © The Japanese Pharmacological Society1-O-C2-2 Oral Sessions
Effect of voluntary exercise after cerebral ischemia on functional recovery
and the peri-infarct cortex
Natsumi Yamaguchi1, Kae Fukumoto1, Toshinori Sawano1, Jin Nakatani1, Daijiro Yanagisawa2,
Ikuo Tooyama2, Hidekazu Tanaka1
1

Lab. Pharmacol., Grad. Sch. Life Sci., Ritsumeikan Univ., 2Dept. Diag. and Therap. for Brain Dis., Mol. Neurosci.
Res. Ctr., Shiga Univ. Med. Sci.

Copyright © The Japanese Pharmacological Society1-O-C2-3 Oral Sessions
Function of novel Iba1-positive cells appearing in the ischemic core
Toshinori Sawano1, Natsumi Yamaguchi1, Jin Nakatani1, Shinobu Inagaki2,3,
Takayuki Nakagomi4, Tomohiro Matsuyama4, Hidekazu Tanaka1
1

Lab. Pharmacol., Grad. Sch. Life Sci., Ritsumeikan Univ., 2United Grad. Sch. Child Develop., Osaka Univ., 3Dept.
PT., Yukioka Col. Health Sci., 4Lab. Neurogenesis and CNS Repair., Inst. Adv. Med. Sci., Hyogo Col. Med.

Copyright © The Japanese Pharmacological Society1-O-C2-4 Oral Sessions
Amthamine, a selective histamine H2 receptor agonist alleviates
cerebrovascular damage after traumatic brain injury in mice
Shotaro Michinaga, Kyomi Sonoda, Naoki Inazuki, Tomokazu Watano, Hiroyuki Mizuguchi
Dept. pharmacol. Osaka-ohtani Univ.

Copyright © The Japanese Pharmacological Society1-O-C3-1 Oral Sessions
Effects of high fat diet feeding and lipopolysaccharide treatment onneuroinflammation, neurogenesis, or cognitive function in mice
Toshiaki Ishizuka1, Wataru Nagata1, Sayaka Takahashi1, Hiroyuki Ohta1, Yasushi Satoh2
1Dept. Pharmacol., Natl. Def. Med. Coll., 2Dept. Biochem., Natl. Def. Med. Coll.

Copyright © The Japanese Pharmacological Society1-O-C3-2 Oral Sessions
Recovery of memory deficits by the overexpression of Shati/Nat8l in the
hippocampus in a mouse model of Alzheimer’s disease
Chino Kakeru1, Naotaka Izuo1, Tomoharu Kuboyama2, Chihiro Tohda2, Shinichi Muramatsu3,4,
Atsumi Nitta1
1

Dept of Pharmaceutical and Neuropharmcol Therap, Fact of Pharmaceutical Sci, Grad Univ of Medical andPharm Sci, Univ of Toyama, 2Sect of Neuromedical Sci, Div of Biosci, Inst of Nat Med, Univ of Toyama, 3Div of
Neuro Gene Thera, Open Innov Ctr, Univ of Jichi Med, 4Ctr of Gene & Cell Thera, Ins of Med Sci, Univ of Tokyo

Copyright © The Japanese Pharmacological Society1-O-C3-3 Oral Sessions
Coffee polyphenols prevent cognitive decline and suppress amyloid β
plaques in APP/PS2 transgenic mouse
Keiko Ishida, Masaki Yamamoto, Kensuke Misawa, Hitomi Nishimura, Koichi Misawa,
Naoki Yamamoto, Noriyasu Ota
Kao Corporation Biological Science Research

Copyright © The Japanese Pharmacological Society1-O-C3-4 Oral Sessions
Coffee polyphenols ameliorate cognitive decline via maintenance of bloodbrain barrier (BBB) integrity in senescence-accelerated mouse prone 8(SAMP8)
Nishimura Hitomi, Masaki Yamamoto, Keiko Ishida, Tomoya Hirata, Naoki Yamamoto,
Kouichi Misawa, Takatoshi Murase, Noriyasu Ota
Kao Corporation Biological Science Research

Copyright © The Japanese Pharmacological Society1-O-C3-5 Oral Sessions
Chlorogenic acid (5-caffeoylquinic acid) suppresses cognitive decline byfacilitating Aβ clearance in APP/PS2 transgenic mice
Keiko Ishida, Masaki Yamamoto, Hitomi Nishimura, Tomoya Hirata, Koichi Misawa,
Naoki Yamamoto, Noriyasu Ota
Kao Corporation Biological Science Research

Copyright © The Japanese Pharmacological Society1-O-D1-1 Oral Sessions
Activation of YAP is essential for the myocardial recovery from myocarditis
Shoki Fukuyama1, Yusuke Kametani1, Yuriko Wada1, Shota Suzuki1, Ayaka Umeda1,
Makiko Maeda2, Shota Tanaka1, Masanori Obana1, Yasushi Fujio1
1

Laboratory of Clinical Science and Biomedicine., Grad. Sch. Pharm., Osaka Univ., 2Laboratory of ClinicalPharmacology and Therapeutics., Grad. Sch. Pharm., Osaka Univ.

Copyright © The Japanese Pharmacological Society1-O-D1-2 Oral Sessions
Cardioprotective roles of novel cell death inhibitor, defender against cell
death 1 (Dad1)
Shota Mori1, Shota Tanaka1, Makiko Maeda2, Masanori Obana1, Yasushi Fujio1,2
1

Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., 2Laboratory of ClinicalPharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ.

Copyright © The Japanese Pharmacological Society1-O-D1-3 Oral Sessions
Regulation of fibrosis inhibitory factors by NOX1/NADPH oxidase in H9c2
cardiomyocytes
Kazumi Iwata, Chihiro Yabe-NishimuraDept. Pharmacol., Kyoto Pref. Univ. Med.

Copyright © The Japanese Pharmacological Society1-O-D1-4 Oral Sessions
2,5-Dimethylcelecoxib attenuates cardiac remodeling after cryoinjuryinduced myocardial infarction by suppressing the fibroblast-myofibroblast
transformation
Ikushima Eigo1, Shin Ishikane1, Takehiro Kishigami1, Hiroaki Matsunaga1, Tomohiro Takiguchi2,
Yumiko Toyohira1, Fumi Takahashi-Yanaga1
1

Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan.,
Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University

2

Copyright © The Japanese Pharmacological Society1-O-D2-1 Oral Sessions
Molecular mechanisms of Doxorubicin-induced cardiomyopathy,
involvement in the impairment of mitophagy
Takeya Sato1, Mikio Muraoka1, Noriko Toda1,2, Guanjie Li1, Masanori Yamauchi2, Masaki Saito1,
Teruyuki Yanagisawa1
1

Dept. Mol. Pharm. Tohoku Univ. Grad.Sch. Med., 2Dept. Anesthesiol. Perioperat. Med. Tohoku Univ. Grad.Sch.
Med

Copyright © The Japanese Pharmacological Society1-O-D2-2 Oral Sessions
Induction of Autophagy Attenuates Imatinib-induced Cardiotoxicity
Miyuki Kobara, Hiroe Toba, Tetsuo Nakata
Department of Clinical Pharmacology, Kyoto Pharmaceutical University

Copyright © The Japanese Pharmacological Society1-O-D2-3 Oral Sessions
Oncocardiology of Anticancer Molecular Target Drugs
Kayoko Yamada1,2, Kyoko Yamamoto1,2, Yuka Mizutani1,2, Noriko Ichino1,2, Aoi Mori1,2,
Yukiko Kato1,2, Yasuhito Shimada3, Yuhei Nishimura3, Toshio Tanaka1,2
1

Department of Systems Pharmacology Mie University Graduate School of Medicine, 2Mie University Medical
Zebrafish Research Center, 3Department of Integrative Pharmacology Mie University Graduate School of Medicine

Copyright © The Japanese Pharmacological Society1-O-D2-4 Oral Sessions
Cancer cachexia-induced myocardial impairment could be improved byvoluntary wheel running
Miki Nonaka1, Susumu Ueno2, Ryo Kakigi3, Nagomi Kurebayashi4, Takashi Murayama4,
Kanako Miyano5, Kiyoshi Terawaki6, Takashi Sakurai4, Yasuhito Uezono1
1

Dept. Pain Control Res., Jikei Univ. Sch. Med., 2Dept. Occup. Toxicol., Inst. Ind. Ecol. Sci., Univ. Occup. Environ.
Hlth., 3Fac. Management & Information Sci, Josai International University, 4Dept. Pharmacol., Juntendo Univ. Sch.
Med., 5Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., 6Tsumura Res. Labo., Tsumura & Co.

Copyright © The Japanese Pharmacological Society1-O-D3-1 Oral Sessions
Effects of RyR2 specific inhibitors on arrhythmia in CPVT model mice
Nagomi Kurebayashi1, Takashi Murayama1, Koichiro Ishii1, Masato Konishi1, Masami Sugihara2,
Shuichi Mori3, Hiroto Iinuma3, Mari Ishigami-Yuasa3, Nobuyuki Murakoshi4, Hiroyuki Kagechika3,
Takashi Sakurai11

Dept Cell Mol Pharmacol, Juntendo Univ Grad Sch Med, 2Dept Clin Lab Med, Juntendo Univ Gad Sch Med, 3IBB,Tokyo Med Dent Univ, 4Dept Cardiol, Fac Med, Univ Tsukuba

Copyright © The Japanese Pharmacological Society1-O-D3-2 Oral Sessions
Cardiac safety pharmacological characteristics of class Id antiarrhythmic
drug ranolazine in the halothane-anesthetized dog
Yoshio Nunoi1,2, Ryuichi Kambayashi1, Ai Goto1, Yoshiki Hirokawa1, Hiroko Izumi-Nakaseko1,
Mihoko Hagiwara-Nagasawa1, Yoshinori Takei3, Akio Matsumoto4, Shinichi Kawai5,
Yoshinori Watanabe2, Atsushi Sugiyama1,3,4,5
1

Dept. Pharmacol., Faculty Med., Toho Univ., 2Div. Cardiovasc. Surg., Dept. Surg., Faculty Med, Toho Univ.,3Dept.
Translational Research & Cellular Therapeutics, Faculty Med., Toho Univ.,4Dept. Aging Pharmacol., FacultyMed., Toho Univ., 5Dept. Inflammation & Pain Control Research, Faculty Med., Toho Univ.

Copyright © The Japanese Pharmacological Society1-O-D3-3 Oral Sessions
Analysis of onset mechanisms on clinically reported, lamotrigine-induced
cardiovascular adverse events as a reverse translational research using thehalothane-anesthetized dogs
Ai Goto1, Yoshiki Hirokawa1, Yoshio Nunoi2, Ryuichi Kambayashi2, Hiroko Izumi-Nakaseko1,2,
Mihoko Hagiwara-Nagasawa2, Akio Matsumoto3, Yoshinori Takei4, Shinichi Kawai5,
Atsushi Sugiyama1,2,3,4,5
1

Dept. Pharmacol., Grad. Sch. Med., Toho Univ., 2Dept. Pharmacol., Faculty. Med., Toho Univ.,3Dept. Aging
Pharmacol., Faculty. Med., Toho Univ.,4Dept. Translational Research & Cellular Therapeutics., Faculty. Med.,
Toho Univ., 5Dept. Inflammation & Pain Control Research, Faculty. Med., Toho Univ.

Copyright © The Japanese Pharmacological Society1-O-D3-4 Oral Sessions
Electropharmacological effects of licorice decoction on the heart: integral
assessment using in vitro and in vivo models
Hiroko Izumi-Nakaseko1, Koki Chiba2, Ai Goto1, Ryuichi Kambayashi1, Yoshio Nunoi1,
Mihoko Hagiwara-Nagasawa1, Akio Matsumoto3, Yoshinori Takei4, Shinichi Kawai5,
Atsushi Sugiyama1,3,4,5
1

Dept. Pharmacol., Faculty. Med., Toho Univ.,2Dept. Trad. Med., Faculty Med., Toho Univ.,3Dept. Translational
Research & Cellular Therapeutics, Faculty Med., Toho Univ., 4Dept. Aging Pharmacol., Faculty Med., Toho Univ.,
5
Dept. Inflammation & Pain Control Research, Faculty Med., Toho Univ.

Copyright © The Japanese Pharmacological Society1-O-D3-5 Oral Sessions
Nardilysin controls heart rate through the transcriptional regulation of ionchannels critical for sinus automaticity.
Mikiko Ohno1, Hiroshi Matsuura2, Takeru Makiyama3, Yasuhiko Koujitani3, Kiyoto Nishi3,
Hirotaka Iwasaki1, Shintaro Matsuda3, Takeshi Kimura3, Eiichiro Nishi1
1

Dept. Pharm. Shiga Univ. Med. Sci., 2Dept. Phisio. Shiga Univ. Med. Sci., 3Dept. Cardiovasc. Med, Grad. Sch.
Med., Kyoto Univ.

Copyright © The Japanese Pharmacological Society1-O-G1-1 Oral Sessions
Generation of a transgenic zebrafish line suitable for in vivo imaging of
apoptosis in liver
Aina Higuchi1, Eri Wakai1, Yuka Adachi1, Tomoko Tada2, Junko Koiwa1, Takashi Shiromizu1,
Toshio Tanaka3, Yuhei Nishimura1
1Dept. Integrative Pharm., Mie Univ. Grad. Sch. Med., 2JPN. Red Cross Ise Hosp., 3Dept. Systems Pharm., Mie
Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society1-O-G1-2 Oral Sessions
Roles of prostaglandin I2 and TNF-alpha in liver regeneration in mice
Koh-ichi Yuhki1, Tomohiro Hirata1, Yoshitaka Imamichi1, Hitoshi Kashiwagi1, Koh Nakayama1,
Shuh Narumiya2, Fumitaka Ushikubi1
1

Dept. Pharmacol., Asahikawa Medical Univ., 2Dept. drug discovery Med., Kyoto Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society1-O-G1-3 Oral Sessions
Macrophages promote liver repair after monocrotaline-induced liver injury
via SDF-1/CXCR4 axis
Yoshiya Ito1,2, Fumisato Otaka1,2, Takuya Goto1,2, Kanako Hosono1,2, Ko Hatanako1,
Hideki Amano1,2
1

Dept. Pharm., Sch. Med., Kitasato Univ., 2Dept. Mol. Pharm., Grad. Sch. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society1-O-G1-4 Oral Sessions
Injured liver-derived TNF-alpha induces muscular atrophy due to liver
fibrosis
Momo Goto1, Tamaki Kurosawa1,2, Noriyuki Kaji3, Satoshi Aikiyo1, Taiki Mihara1,
Madoka Uezumi2, Masashi Toyoda4, Nobuo Kanazawa5, Tatsu Nakazawa6, Akiyoshi Uezumi2,
Masatoshi Hori1
1

Dept. Vet. Pharmacol., Grad. Sch. Agri. Life Sci., The Univ. of Tokyo,2Muscle Aging and Regenerative Med., Tokyo
Metropolitan Inst. of Gerontology, 3Lab. of Vet. Pharmacol., Sch. of Vet. Med., Azabu Univ.,4Vascular Med., Tokyo
Metropolitan Inst. of Gerontology, 5Dept. of Surg., Tokyo Metropolitan Geriatric Hosp. and Inst. of Gerontology,
6
Dept. of Surg., Seibo Hosp.

Copyright © The Japanese Pharmacological Society1-O-G2-1 Oral Sessions
Anti-colitis effect of a new component isolated from Qing-dai (Sei-tai)
Saki Imai, Moe Miyashita, Tae Tsuboi, Yoichiro Isohama
Lab. appl. Pharmacol, Fac. of Pharm. Sci., Tokyo Univ. of Sci.

Copyright © The Japanese Pharmacological Society1-O-G2-2 Oral Sessions
An Indigo Naturalis constituent indigo ameliorates colitis by accelerating
wound closure
Takaaki Shimizu, Chisa Takagi, Toshinori Sawano, Jin Nakatani, Hidekazu Tanaka
Lab. Pharmacy., Grad. Sch. Life Sci., Ritsumeikan Univ.

Copyright © The Japanese Pharmacological Society1-O-G2-3 Oral Sessions
A close relationship between networks of interstitial cells of Cajal andgastrointestinal transit in vivo
Kamizaki Moe1, Kazuhisa Kishi1, Noriyuki Kaji2, Satoshi Iino3, Masatoshi Hori1
1

Dept. Veterinary Pharmacol. The Univ. of Tokyo,2Dept. Pharmacol. Azabu Univ., 3Dept. Morphological andPhysiological Sciences Univ. of Fukui

Copyright © The Japanese Pharmacological Society1-O-G2-4 Oral Sessions
Construction of an in vitro human M cell model using RANKLTatsuya Ono1, Kazuya Masuda2, Akinobu Kajikawa1, Kenji Yokota1, Shizunobu Igimi11Dept. Applied Biol. Chem., Tokyo Univ. of Agr.,2Dept. Food Sci. Nutrition, Fac. Life and Environ. Sci., Showa
Woman's Univ.

Copyright © The Japanese Pharmacological Society1-O-G3-1 Oral Sessions
Thromboxane receptor signaling regulates lymphangiogenesis andlymphatic drainage function in diaphragm during lipopolysaccharideinduced peritonitis
Kanako Hosono1,2, Yoshiya Ito1,2, Hiromi Matsuda1,3, Seri Tsuru1,3, Ko Hatanaka1,
Masataka Majima1,4, Shuh Narumiya5, Hideki Amano1,2
1

Dept. Pharm., Sch. Med., Kitasato Univ., 2Dept. Mol. Pharm., Grad. Sch. Med., Kitasato Univ., 3Dept. Anesth., Sch.
Med., Kitasato Univ., 4Fac. Health & Med. Sci., Kanagawa Inst. Tech., 5Dept. Drug Discovery Med., Grad. Sch.
Med., Kyoto Univ.

Copyright © The Japanese Pharmacological Society1-O-G3-2 Oral Sessions
Differentiation-inducing factor-1 accelerates adipogenic differentiation andsuppresses the osteogenic differentiation of bone marrow-derived
mesenchymal stem cells
Shin Ishikane1, Eigo Ikushima1, Tomohiro Takiguchi1,2, Hiroaki Matsunaga1, Takehiro Kishigami1,
Yumiko Toyohira1, Fumi Takahashi11Dept. Pharmacol., Sch. Med., Univ. Occup. & Environ. Health., 2Dept. Clin. Pharm., Fac. Med. Sci., Kyushu Univ.

Copyright © The Japanese Pharmacological Society1-O-G3-3 Oral Sessions
mTOR regulates skeletogenesis through complex-dependent and complexindependent pathways
Kazuya Tokumura, Sayuki Iwahashi, Kazuya Fukasawa, Takashi Iezaki, Eiichi Hinoi
Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceutical Univ

Copyright © The Japanese Pharmacological Society1-O-G3-4 Oral Sessions
mTORC1 hyperactivation causes skeletal defects during embryogenesis
Sayuki Iwahashi, Kazuya Tokumura, Kazuya Fukasawa, Takashi Iezaki, Eiichi Hinoi
Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceutical Univ

Copyright © The Japanese Pharmacological Society1-O-G3-5 Oral Sessions
NOX1/NADPH oxidase accelerates the onset of experimental arthritis
Misaki Matsumoto, Chihiro Yabe-NishimuraDept. Pharmacol. Kyoto Pref. Univ. Med.

Copyright © The Japanese Pharmacological Society