1-P1-LB46 LBS
Clustering of acetylcholine receptors in a muscular atrophy model
Yuko Fukunaga, Yo Kimura, Hina Kikuchi, Haruka Furuyama
Animal Risk Management, Chiba Institute of Science

Copyright © The Japanese Pharmacological Society

1-P1-LB47 LBS
Differential projection patterns between the insular and medial prefrontal
cortices to the the nucleus accumbens in rats
Yuka Nakaya, Kiyofumi Yamamoto, Masayuki Kobayashi
Department of Pharmacology, Nihon University School of Dentistry

Copyright © The Japanese Pharmacological Society

1-P1-LB48 LBS
Presynaptic NK1 receptor activation by substance P suppresses EPSCs via
nitric oxide synthesis in the rat insular cortex
Matsumura Sachie, Kiyofumi Yamamoto, Masayuki Kobayashi
Dept. Pharmacol., Nihon Univ. Sch. of Dent.

Copyright © The Japanese Pharmacological Society

1-P1-LB49 LBS
Assessment of CB agonist CP55940 in maturity for rat hippocampal neurons
using a high-throughput immunocytochemical assay and image digital
analysis
Mitsuoka Toshinari1, Shogo Mase1,2, Noriko Koganezawa2, Yuichi Katou1, Izuo Tutui1,Tomoaki Shirao2, Yuko Sekino1
1

Lab. HCBDD, Grad. Sch. Pharm, Univ Tokyo, 2Dept Pharmacol, Gunma Univ, Grad Sch Med.

Copyright © The Japanese Pharmacological Society

1-P1-LB50 LBS
Deficit of cognitive function induced by the reduction of mice hippocampal
Shati/Nat8l
Ikejima Daiki1, Shin-ichi Muramatsu2,3, Atsumi Nitta1
1Grad. Sch.Med. Pharm Sci., Toyama Univ, 2Jichi Medical Univ, 3Tokyo Univ

Copyright © The Japanese Pharmacological Society

1-P2-LB47 LBS
Enhancement of myogenic differentiation by MMP inhibition and attenuationof the enhancement effect in senescent cells
Hiroki Sakai1, Takeshi Honda1, Kouetsu Ogasawara2, Masataka Asagiri1
1Yamaguchi Univ. Grad. Sch. Med., 2IDAC. Tohoku Univ.

Copyright © The Japanese Pharmacological Society

1-P2-LB48 LBS
Changes in expression of fibrosis-related factors in alveolar epithelial cells
and macrophages by forced expression of p16
Yasuhiro Takenouchi, Yoshifumi Niiyama, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto
Dept. Pharmacol., Kawasaki Med. Sch.

Copyright © The Japanese Pharmacological Society

1-P2-LB49 LBS
Signal transduction mechanism for S-allyl-L-cysteine-induced cellproliferation in primary cultures of adult rat hepatocytes
Hajime Moteki, Kazuki Kurihara, Masahiko Ogihara, Mitshtoshi KimuraDept. Clin. Pharmacol., Fac. Pharma. Sci., Josai Univ.

Copyright © The Japanese Pharmacological Society

1-P2-LB50 LBS
The oxidative stress response and signaling pathways in diffuse- andintestinal-type gastric cancer.
Shihori Tanabe1, Sabina Quader2, Ryuichi Ono3, Horacio Cabral4, Kazuhiko Aoyagi5,Akihiko Hirose1, Ed Perkins6, Hiroshi Yokozaki7, Hiroki Sasaki8
1Div. Risk Assess., CBSR, Natl. Inst. Health Sci., 2iCONM, 3Div. Cell. Mol. Tox., CBSR, Natl. Inst. Health Sci.,
4Grad. Sch. Engineer., The Univ. of Tokyo,5Dept. Clin. Genomics, FIOC, Natl. Cancer Ctr. Res. Inst., 6USACEERDC Environ. Lab., 7Dept. Path. Grad. Sch. Med., Kobe Univ., 8Dept. Transl. Oncol., FIOC, Natl. Cancer Ctr.
Res. Inst.

Copyright © The Japanese Pharmacological Society

2-P1-LB45 LBS
Physiological function of the descending projection from the insular cortex
to the parabrachial nucleus revealed by optogenetics
Kensuke Hirose, Yuka Nakaya, Masayuki Kobayashi
Dept. of Pharmacol. Nihon Univ. Sch. of Dent.

Copyright © The Japanese Pharmacological Society

2-P1-LB46 LBS
Restoration of CLSP activity rescues Alzheimer disease
Masaaki Matsuoka, Yuichi Hashimoto, Shinya Kusakari, Mikiro Nawa, Yuka Toyama
Department of Pharmacology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan

Copyright © The Japanese Pharmacological Society

2-P1-LB47 LBS
The Nrf2 gene may not be involved in the anti-inflammatory effects of Nrf2
activators
Yasuhiko Izumi1, Momoko Uegomori1, Fumika Kobayashi1, Koya Koya Yamaki1, Toshiaki Kume2,
Yutaka Koyama1
1Lab. Pharmacol., Kobe Pharm. Univ., 2Dept. Appl. Pharmacol, Grad. Sch. of Med. and Pharm. Sci., Univ. ofToyama

Copyright © The Japanese Pharmacological Society

2-P1-LB48 LBS
Influence of mitochondria dysfunction in microglia on inflammation-evoked
type I interferon expression
Momoka Iwamoto, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka
Dept. Pharmacol., Grad.Sch. Biomed. & Helth Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society

2-P1-LB49 LBS
The effects of chronic administration of methamphetamine on circadianrhythm of mice
Nakaya Mizuki, Ryousuke Sato, Kouki Nagasawa, Yukina Yoshida, Juri Hayashi, Yuki Ishi,Kazuko Hamada, Toshiyuki HamadaIUHWCopyright © The Japanese Pharmacological Society

2-P2-LB47 LBS
Involvement of TRPC3-Nox2 axis in Duchenne muscular dystrophy
Koichi Ayukawa1, Chiemi Toyama1, Kazuhiro Nishiyama1, Yuri Kato1, Tomohiro Tanaka2,Akiyuki Nishimura2, Motohiro Nishida1,2
1

Graduate School of Pharmaceutical Sciences, Kyushu University, 2National Institute for Physiological Sciencesand Exploratory Research Center on Life and Living Systems, National Institutes of Natural SciencesCopyright © The Japanese Pharmacological Society

2-P2-LB48 LBS
Suppression of SARS-CoV-2-induced lung injury by ACE2-likecarboxypeptidase B38-CAP in COVID-19 mouse model
Tomokazu Yamaguchi1, Takafumi Minato1, Midori Hoshizaki1,2, Masamitsu Asaka3,Satoru Nirasawa4, Mayumi Niiyama5, Masaki Imai6, Saori Takahashi7, Daichi Utsumi3,
Jianbo An1, Satoshi Nagata5, Haruhiko Kamada5, Yoshihiro Kawaoka6, Yasuhiro Yasutomi3,Yumiko Imai2, Keiji Kuba1
1

Department of Biochemistry and Metabolic Science, Akita University, 2Laboratory of Regulation of Intractable
Infectious Diseases, NIBIOHN, 3Tsukuba Primate Research Center, NIBIOHN,4Biological Resources and PostHarvest Division, Japan International Research Center for Agricultural Sciences, 5Laboratory of Antibody Design,
NIBIOHN, 6Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,
University of Tokyo, 7Akita Research Institute of Food and Brewing

Copyright © The Japanese Pharmacological Society

2-P2-LB49 LBS
Novel role of pyruvate dehydrogenase PDH regulation of histone
acetylation and gene expression in breast cancer cells
Nakayama Koh
Dept. of Pharmacol., Asahikawa Med. Univ.

Copyright © The Japanese Pharmacological Society2-P2-LB50 LBS
Mitochondrial fusion factor OPA1 sustains gefitinib-resistance in lungadenocarcinoma cells
Masafumi Noguchi1, Susumu Kohno2, Keitaro Shibata1, Takashi Kohno3, Noriko Gotoh4,Chiaki Takahashi4, Atsushi Hirao5, Luca Scorrano1, Atsuko Kasahara4
1

Dept. of Biol., Univ. of Padua, Venetian Inst. of Mol. Med., 2Cancer Res. Inst., Kanazawa Univ., 3National CancerCtr. Res. Inst., 4Inst. for Frontier Sci. Initiative, Cancer Res. Inst., Kanazawa Univ., 5Cancer Res. Inst., WPI Nano
Life Sci. Inst., Kanazawa Uni.

Copyright © The Japanese Pharmacological Society

3-P1-LB46 LBS
Electrophysiological and anatomical properties of neurons in theventrolateral part of the periaqueductal gray matter in the rat
Kawasaki Shiori, Yuka Nakaya, Masayuki Kobayashi
Dept. Pharmacol., Nihon Univ Sch Dent.

Copyright © The Japanese Pharmacological Society

3-P1-LB47 LBS
Influences of prenatal stress by the communication box on GABAergic
system in the amygdala of mice.
Takayoshi Mamiya1, Ping Lu1, Lingling Lu1, Hiroshi Oda1, Akihiro Mouri1,2,Toshitaka Nabeshima1,2, Masayuki Hiramatsu1
1Dept. Chem. Pharmacol., Fac. Pharm., Meijo Univ., 2Adv. Diagn Sys. Res. Lab., Grad. Sch. Health Sci., Fujita
Health Univ.

Copyright © The Japanese Pharmacological Society

3-P2-LB48 LBS
Relationship between plasma extracellular vesicles (EV) and systemic bloodpressure in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
Risa Teranishi, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society

3-P2-LB49 LBS
Reduced white adipose tissue amount in mice lacking mitochondrial protein
p13
Hara Satomi1, Hiroki Ueno1, Masafumi Noguchi2, Wakana Matsuo1, Hitoshi Hashimoto1,3,4,5,6,
Norihito Shintani1
1Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2Dept. Biol., Univ. Padova, 3United Grad.
Sch. Child Dev., Osaka Univ., 4Div. Biosci., Inst. Datability Sci., Osaka Univ., 5Transdimensional Life Imaging Div.,
Inst. Open Transdiscip. Res. Initiatives, Osaka Univ, 6Dept. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ.

Copyright © The Japanese Pharmacological Society

3-P2-LB50 LBS
Novel Reporter Systems Monitoring NFkB activation Can Be Applied toHighThroughput Screening.
Yonezawa TomoCopyright © The Japanese Pharmacological Society