1-O-001 Oral Sessions
Important role of neuronal histamine N-methyltransferase in brain functions
Takeo Yoshikawa1, Yurika Komatsu1, Kensuke Matsuzawa1, Rina Otsuka1, Fumito Naganuma1,2,
Tadaho Nakamura1,2, Kazuhiko Yanai1
1

Tohoku Univ Grad Sch Med Dept Pharmacol, 2TMPU Faculty of Medicine, Pharmacology

Copyright © The Japanese Pharmacological Society1-O-002 Oral Sessions
5-HT1A and 5-HT1B receptor-mediated inhibition of excitatory synaptictransmission onto rat basal forebrain cholinergic neurons
1

1,2

1

Toshihiko Momiyama , Takuma Nishijo , Etsuko Suzuki
1

Dept. Pharmacol. Jikei Univ. Sch. Med., 2Dept. Mol. Neurobiol., Inst. Develop. Res, Aichi Disability Center

Copyright © The Japanese Pharmacological Society1-O-003 Oral Sessions
Involvement of 8-nitro-cGMP - ERK signals in the induction of long-term
depression in the mouse cerebellum
Sho Kakizawa1, Tomoko Arasaki2, Yasushi Satoh3, Shogo Endo2
1

Dept. Biol. Chem., Grad. Sch. Pharmaceu. Sci., Kyoto Univ., 2Memory Neurosci., Research Team for Aging
Neurosci., Tokyo Metro. Inst. Gerontology,3Dept. Biochem., Fac. Med., National Defense Medical School

Copyright © The Japanese Pharmacological Society1-O-004 Oral Sessions
Development of a method for single-molecule imaging in the brain tissue
Yohei Okubo1, Shigeyuki Namiki2, Daisuke Asanuma2, Takashi Sakurai1, Kenzo Hirose2
1

Dept. Pharmacol., Grad. Sch. Med., Juntendo Univ., 2Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo

Copyright © The Japanese Pharmacological Society1-O-005 Oral Sessions
A fluorescent sensor for the real-time measurement of extracellular oxytocin
dynamics in the brain
Daisuke Ino, Hiroshi Hibino
Dept. Pharmacol., Grad. Sch. Med., Osaka Univ.

Copyright © The Japanese Pharmacological Society1-O-006 Oral Sessions
Hepatocellular carcinoma induces tissue osmolyte and water retention, andbody mass loss in rats
Kento Kitada, Satoshi Kidoguchi, Daisuke Nakano, Akira Nishiyama
Department of Pharmacology, Faculty of Medicine, Kagawa University

Copyright © The Japanese Pharmacological Society1-O-007 Oral Sessions
Anemia disrupts renal compensatory growth without paralysis of growthsignaling pathway
Daisuke Nakano, Yu Guan, Anqi Zhang, Akira Nishiyama
Dept. Pharmacol., Kagawa Univ.

Copyright © The Japanese Pharmacological Society1-O-008 Oral Sessions
Distal tubular NCX1 plays a critical role in ischemic acute kidney injury
Takayuki Nemoto1, Rumie Wakasaki2, Hideaki Tagashira1, Tomo Kita1, Naoko Nakajima1,
Satomi Kita1,3, Takahiro Iwamoto1
1

Dept. Pharmacol., Fac. Med., Fukuoka Univ., 2Anesthesiol., Chikushi Hosp., Fukuoka Univ., 3Dept., Pharmacol.,Fac. Pharma. Sci., Tokushima Bunri Univ.

Copyright © The Japanese Pharmacological Society1-O-009 Oral Sessions
The effects of TRPC6 activation by mechanical and receptor stimulations on
podocyte-mediated filtration barrier function
Jun Ichikawa1, Midori Nakagawa2, Ryuji Inoue2
1

Sano Nihon Univ. Coll., 2Dept. Physiol., Fukuoka Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society1-O-010 Oral Sessions
IL-6 family cytokines, STAT3 activators, exhibit differential effects in aligand-specific manner in podocytes
Mitsuoka Sayuri1, Masanori Obana1,2,3,4, Yoshiaki Miyake1, Ayaha Yamamoto1, Shota Tanaka1,
Makiko Maeda5, Yoshiaki Okada1, Yasushi Fujio1,2
1

Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University,
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research
Initiatives (OTRI), Osaka University, 3Global Center for Medical Engineering and Informatics (MEI), Osaka
University, 4Radioisotope Research Center, Institute for Radiation Sciences, Osaka University, 5Laboratory ofClinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
2

Copyright © The Japanese Pharmacological Society1-O-011 Oral Sessions
Distinct downstream targets of the medial prefrontal cortex underlie discrete
antidepressant responses to ketamine
Ryota Shinohara1, Brendan D. Hare2, Rong-Jian Liu2, Jin Hua Li2, Xiao-Yuan Li2, Catharine
H. Duman2, Ralph J. DiLeone2, Ronald S. Duman2
1

Div. Pharmacol., Kobe Univ. Grad. Sch. Med., 2Dept. Psychiatry, Yale Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society1-O-012 Oral Sessions
Effects of KNT-127, a delta opioid receptor agonist, on sleep in mice.
Takashi Iwai1, Risako Watanabe1, Shigeto Hirayama2, Oyama Misa1, Shun Watanabe1,
Hideaki Fujii2, Mitsuo Tanabe1
1

Laboratory of Pharmacology, School of Pharmacy, Kitasato University, Tokyo, Japan.,2Laboratory of Medicinal
Chemistry, School of Pharmacy, Kitasato University, Tokyo, Japan.

Copyright © The Japanese Pharmacological Society1-O-013 Oral Sessions
Contribution of kynurenine-3-monooxygenase to hemorrhagic neuron injury
Mana Furutaguchi, Masatoshi Ohnishi, Takuya Shigemasa, Shunpei Tasaka, Atsuko Inoue
Dept. Pharmacotherap., Fac. Pharm. & Pharmaceut. Sci., Fukuyama Univ.

Copyright © The Japanese Pharmacological Society1-O-014 Oral Sessions
The effect of sphingosine related pathway activation in early brain injury
after subarachnoid hemorrhage in rat
Hasegawa Yu1,2, Hidenori Suzuki3, Orhan Altay4, Motohiro Morioka2
1

Department of Pharmaceutical Sciences, School of Pharmacy at Fukuoka, International University of Health andWelfare, 2Department of Neurosurgery, Kurume University School of Medicine, 3Department of Neurosurgery, Mie
University School of Medicine, 4Department of Physiology, Loma Linda University School of Medicine

Copyright © The Japanese Pharmacological Society1-O-015 Oral Sessions
Inhibitory effects of pine nodule extract on mental stress-induced increases
in sympathetic nervous activity in young students
Nobuyuki Yanagihara1, Miyuki Takada1, Haruna Ariyoshi1, Noriaki Sato2, Hui Shao3, Taizo Kita4
1

Laboratory of Pharmacology, Faculty of Food and Nutrition, Kyushu Nutrition Welfare University Kitakyushu,
Shared-Use Research Center, University of Occupational and Environmental Health,3Tokujun Pharmaceutical
Research Institute, 4Department of Food Science and Human Nutrition, Faculty of Agriculture, Setsunan University
2

Copyright © The Japanese Pharmacological Society1-O-016 Oral Sessions
TRAb-IgM induced by Epstein-Barr virus reactivation does not have thyroid
stimulating effect, but injures the thyroid follicular epithelial cells andreleases thyroid antigens
Nagata Keiko1, Kazuhiko Hayashi2, Yukio Satoh3, Mitsuhiko Osaki4, Yoshinori Ichihara1,
Tatsuya Sawano1, Agung Kurniawan Priyono1, Kazuhiko Matsuzawa1, Junichiro Miake1,
Takeshi Imamura1
1

Division of Pharmacology, Faculty of Medicine, Tottori University, 2Department of Pathology, Faculty of
Medicine, Tottori University, 3Division of Developmental Biology, School of Life Science, Faculty of Medicine,
Tottori University, 4Division of Experimental Pathology, School of Life Science, Faculty of Medicine, Tottori
University

Copyright © The Japanese Pharmacological Society1-O-017 Oral Sessions
Maternal high calorie diet during pregnancy induces abnormal hepatic
glycogenolysis in the offspring and it is mitigated by osteocalcin
Tomoyo Kawakubo-Yasukochi1, Ena Yano1, Soi Kimura1,2, Akiko Mizokami1, Yoshikazu Hayashi3,
Atsushi Yasukochi2, Seiji Nakamura2, Eijiro Jimi1, Masato Hirata4
1

OBT Res Ctr, Fac Dent Sci, Kyushu Univ, 2Sec Oral Maxillofac Oncol, Kyushu Univ, 3Div Func Struct, Dept
Morphol Biol, Fukuoka Dent Coll, 4OM Res Ct., Fukuoka Dent Coll

Copyright © The Japanese Pharmacological Society1-O-018 Oral Sessions
From zebrafish to clinical: Rhamnan sulfate improves constipation with gut
microbiota alteration in double-blind placebo-controlled trial.
Yasuhito Shimada1,2,3, Masahiro Terasawa2,4, Fumiyoshi Okazaki2,5, Hiroko Nakayama2,6,
Liqing Zang2,6, Kocihi Matsuda4, Kaori Nishimura4, Ryota Uchida4, Norihiro Nishimura2,61

Dept. Int Pharm., Grad. Sch. Med., Mie Univ., 2Mie Univ. Adv. Sci. Res. Cen., Bioinfo., 3Mie Univ. Zebrafish. Cen.,
4
Konan Chem Manufact Co., Ltd, 5Grad. Sch. Bioresource, Mie Univ., 6Grad. Sch. Reg. Innov., Mie Univ.

Copyright © The Japanese Pharmacological Society1-O-019 Oral Sessions
Characteristics of the adipocytes differentiated by a glucocorticoid receptor
antagonist RU486
Katsuya Hirano, Takeshi Hashimoto
Dept. Cardiovasc. Physiol., Fac. Med., Kagawa Univ.

Copyright © The Japanese Pharmacological Society1-O-020 Oral Sessions
Negative impact of heparan sulfate in hepatocytes on insulin sensitivity
Takuro Matsuzawa, Naho Kodama, Uta Kudomi, Kazuhiko Yanai, Takeo Yoshikawa
Dept. of Pharmacol. Tohoku. Univ. Grad. Sch. of Med.

Copyright © The Japanese Pharmacological Society1-O-021 Oral Sessions
The ameliorating effect of molecular hydrogen on intestinal injury in high fat
diet-loaded senescence-accelerated mouse
Sayaka Takahashi, Keichi Nakagawa, Wataru Nagata, Akiho Koizumi, Toshiaki Ishizuka
National Defense Medical college

Copyright © The Japanese Pharmacological Society1-O-022 Oral Sessions
Effects of Rikkunshi-To on the donepezil-induced gastrointestinal symptoms
in mice
Kouichi Yamamoto
Dept. Radiol. Sci. Fac. Health Sci. Morinomiya Univ. Med. Sci.

Copyright © The Japanese Pharmacological Society1-O-023 Oral Sessions
Doxorubicin impaired mitochondrial respiration lead to cause the lethal
cardiotoxic damage
Takeya Sato1, Noriko Toda2, Masanori Yamauchi2, Takaaki Abe1
1

Tohoku Univ. Grad. Sch. Med. Clin. Biol. Horm. Regul., 2Tohoku Univ. Grad. Sch. Med. Anesth. Periop.

Copyright © The Japanese Pharmacological Society1-O-024 Oral Sessions
Development of Supportive Care for Anticancer Drugs Based on Real World
Data; Evaluation of the Therapeutic and Preventive Effects of Statins on
Peripheral Neuropathy
Fuka Aizawa1, Haruna Kajimoto2, Daishi Moriyama2, Ami Okabayashi2, Mitsuhiro Goda1,2,
Hirofumi Hamano3, Kenta Yagi3, Yuki Izawa- Ishizawa4, Yoshito Zamami2,5, Keisuke Ishizawa1,21

Dept. Pharm., Tokushima Univ. Hosp., 2Dept. Clin. Pharmacol. & Therap., Grad. Sch. of Biomed. Sci., Tokushima
Univ., 3Clin. Res. Ctr. Dev. Therap., Tokushima Univ. Hosp.,4Dept. Pharmacol., Grad. Sch. of Biomed. Sci.,
Tokushima Univ., 5Dept. Pharm., Okayama Univ. Hosp.

Copyright © The Japanese Pharmacological Society1-O-025 Oral Sessions
Research and Development of Next Generation Zebrafish Developmental
Toxicity Screening System
Toshio Tanaka1,2, Hajime Kojima3, Michio Fujiwara4, Kanako Mori4, Aoi Mori1,2, Rino Sawada1,2,
Kyoko Yamamoto1,2, Kayoko Yamada1,2, Yuka Mizutani1,21

Dept.Syst.Pharmacol.Mie Univ.Grad.Sch.Med, 2Med.Zebrafish.Res.Ctr, 3Nat.Inst.of Health Sci., 4Drug Safety Res.
Labs. Astellas Pharma Inc.

Copyright © The Japanese Pharmacological Society1-O-026 Oral Sessions
Conducting online pharmacology role-playing on medical-students consideration of pros and cons from the results of a two-year students
questionnaire surveyTomoe Fujita1, Shuichi Kojima1, Keitaro Hayashi1, Motoshi Ouchi1, Naoki Aizawa1, Gen Takei1,
Asuka Morita1, Sawako Tanaka-Nakadate1, Satomi Tateno1, Mio Maekawa1, Toshihiko Yanagita2
1

Dep. of Pharmacol. and Toxicology, Dokkyo Med. Univ., Sch.of Med.,2Dept. of Clin.Pharmacol., Sch.of Nursing,Fac. of Med., Univ. of Miyazaki

Copyright © The Japanese Pharmacological Society1-O-027 Oral Sessions
Inflammatory responses by retinal astrocytes during pathogenesis ofnormal-tension glaucoma
Youichi Shinozaki1, Alex Leung3, Kazuhiko Namekata4, Kenji Kashiwagi5, Nobuhiko Ohno6,7,
Eiji Shigetomi1,2, Takahiro Segawa8, Takayuki Harada4, Shin-ichi Ohnuma3, Schuichi Koizumi1,2
1

Dept. Neuropharmacol., Grad. Sch. Med., Univ. Yamanashi, 2GLIA Center, Univ. yamanashi, 3Inst. Ophthalmol.,
UCL, 4Vis. Res. Project., Tokyo Metr. Inst. Med. Sci.,5Dept. Ophthalmol, Interdiscip. Grad. Sch. Med. Univ.
Yamanashi, 6Div. Ultrastruct. Res., Natl. Inst. Physiol. Sci., 7Div. Anat., Jichi Med. Univ., 8Cent. Life Sci. Res., Univ.
Yamanashi

Copyright © The Japanese Pharmacological Society1-O-028

Oral Sessions
2+

Macroscopic imaging analysis of astrocytic Ca activities inneurodegenerative disease model mouse
Yuki Motegi, Masamitsu Iino, Kazunori Kanemaru
Department of Physiology, Nihon University School of Medicine

Copyright © The Japanese Pharmacological Society1-O-029 Oral Sessions
The modulation of purine metabolisms by fibroblast growth factor 2 via
several intracellular signaling pathways in cultured astrocytes
Ryota Eguchi, Ken-ichi Otsuguro
Lab. of Pharmacol., Fac. of Veterinary Medicine, Hokkaido Univ.

Copyright © The Japanese Pharmacological Society1-O-030 Oral Sessions
Effect of tumor releasing factor, cGAMP on gene expression and calcium
response in astrocytes
Momoko Goto1, Toya Okawa1, Daiki Shirane2, Hiroki Tanaka2, Hidetaka Akita2, Akihiro Hisaka1,
Hiromi Sato1
1

Clinical Pharmacology & Pharmacometrics, Grad. Sch. Pharmaceut. Sci., Chiba Univ., 2Design and Drug
Disposition, Grad. Sch. Pharmaceut. Sci., Chiba Univ.

Copyright © The Japanese Pharmacological Society1-O-031 Oral Sessions
Astrocytic control of microglial engulfment during postnatal development,
which fates a lifelong cortical circuits
Yosuke Danjo1,2, Youichi Shinozaki1,2, Ken-Ichi Dewa3, Kenji Kobayashi1,2, Takahiro Segawa4,
Eiji Shigetomi1,2, Schuichi Koizumi1,2
1

Dept Neuropharmacol, Interdiscip Grad Sch Med, Univ Yamanashi, 2Yamanashi GLIA Center,3Glia-Neuron Circuit
Dynamics, RIKEN Center for Brain Science, 4Cent Life Sci Res., Univ. Yamanashi

Copyright © The Japanese Pharmacological Society1-O-032 Oral Sessions
Cardioprotective Effects of a Nonsteroidal Mineralocorticoid Receptor
Blocker, Esaxerenone, in Dahl Salt-Sensitive Hypertensive Rats
Asadur Rahman1, Tatsuya Sawano2, Kento Kitada1, Takeshi Imamura2, Daisuke Nakano1,
Akira Nishiyama1
1

Department of Pharmacology, Kagawa University Medical School, 2Division of Pharmacology, Faculty of
Medicine, Tottori University, Yonago, Japan.

Copyright © The Japanese Pharmacological Society1-O-033

Oral Sessions+

2+

Effect of low Na solution on the spontaneous electrical activity and Ca
dynamics in guinea pig sinoatrial node.
Ryosuke Odaka, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Fclt. Pharmacent. Sci

Copyright © The Japanese Pharmacological Society1-O-034 Oral Sessions
Roles of autophagy in angiotensin II-induced cardiac myocyte apoptosis
Miyuki Kobara, Hiroe Toba, Tetsuo Nakata
Department of Clinical Pharmacology, Kyoto Pharmaceutical University

Copyright © The Japanese Pharmacological Society1-O-035 Oral Sessions
2,5-Dimethylcelecoxib attenuates cardiac fibrosis caused by cryoinjuryinduced myocardial infarction by suppressing the fibroblast-tomyofibroblast transformation via inhibition of TGF-b signaling pathway
Ikushima Eigo1,2, Shin Ishikane1, Tmohiro Takiguchi1,3, Takehiro Kishigami1,2,
Hiroaki Matsunaga1, Yumiko Toyohira1, Yosuke Nishimura2, Fumi Takahashi1
1Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan.,
Department of Cardiovascular surgery, School of Medicine, University of Occupational and Environmental Health,Japan., 3Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University
2

Copyright © The Japanese Pharmacological Society1-O-036 Oral Sessions
TGFβ3 exacerbates myocardial remodeling after myocardial infarction.
Masashi Tomimatsu1, Kosei Yokota1, Shunsuke Kominami1, Shota Tanaka1, Makiko Maeda2,
Yoshiaki Okada1, Masanori Obana1,3, Yasushi Fujio1,3
1

Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., 2Laboratory of ClinicalPharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ., 3Integrated Frontier Research for Medical
Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University

Copyright © The Japanese Pharmacological Society1-SS-67 YIA
Structural analysis of the ABC transporter which transports long chain fatty
acid CoA.
Shinichiro Aiba, Hiroyuki Okamoto, Atsuhiro Tomita, Tsukasa Kusakizako, Osamu Nureki
Tokyo Univ. Science Sch. Biochemistory Dept.

Copyright © The Japanese Pharmacological Society1-YIA-01 YIAInteractions of active zone proteins with Munc13-1 that contribute to theformation of synaptic vesicle release sites
Yusuke Kojima, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose
Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo

Copyright © The Japanese Pharmacological Society1-YIA-02 YIA
Analysis of the effect on TARPγ-8-PSD95 coupling on TARPγ-8 dynamics
Shinkuro Kobayashi, Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose
Dept. Pharmacol., Grad. Sch. Med., the Univ. of Tokyo

Copyright © The Japanese Pharmacological Society1-YIA-03 YIA
Potential role of G protein-coupled receptor 3 in the axonal regeneration
after optic nerve injury in mice
Masuda Shun1,2, Shigeru Tanaka1, Hiroko Shiraki1, Yuusuke Sotomaru3, Kana Harada1,
Izumi Hide1, Yoshiaki Kiuchi2, Norio Sakai1
1

Copyright © The Japanese Pharmacological Society1-YIA-04 YIA
L-DOPA receptor, GPR143, is involved in methylphenidate -induced
locomotion in mice
Uchimura Hiraku1,2, Kaori Kanai1, Daiki Masukawa1, Yoshio Goshima1
1Dept.Mol.Pharmacol.Neurobiol.Yokohama City Univ.Grad.Sch.Med., 2Dept.Psychiatry.Yokohama City Univ.Grad.
Sch.Med.

Copyright © The Japanese Pharmacological Society1-YIA-05 YIA
Molecular characterization of the presubiculum of mouse during
development
Liu Jiayan1, Tetsuhiko Kashima1, Shota Morikawa1, Asako Noguchi1, Nobuyoshi Matsumoto1,
Yuji Ikegaya1,2
1

Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo, 2Inst AI Beyond, Univ Tokyo

Copyright © The Japanese Pharmacological Society1-YIA-06 YIA
GPR143, a L-DOPA receptor, induced migration and proliferation of vascularsmooth muscle cells is involved in monocrotaline-induced pulmonary
hypertension in rats
Masayuki Nakano1,4, Tatsuo Hashimoto2, Motokazu Koga3, Daiki Masukawa1, Shinya Oku3,
Yusuke Mizuno3, Takahisa Goto3, Kouichi Tamura4, Yoshio Goshima1
1Dept. Mol. Pharmacol. Neurobiol., Yokohama City Univ. Grad. Sch. Med., 2Dept. Crit. Care Med. and Dent.,
Kanagawa Dent. Univ. Grad. Sch. Dent., 3Dept. Anesthesiology Crit. Care Med., Yokohama City Univ., Sch. Med.,
4
Dept. Medical Science and Cardiorenal Medicine, Yokohama City Univ., Sch. Med.

Copyright © The Japanese Pharmacological Society1-YIA-07 YIA
Aldosterone enhances stability of atrial fibrillation in the rat model ofchronic volume overload
Megumi Aimoto, Ai Utsunomiya, Rina Kikuchi, Yoshinobu Nagasawa, Akira Takahara
Dept. Pharmacol. Ther., Fdt. Pharmaceut. Sci. Toho Univ.

Copyright © The Japanese Pharmacological Society1-YIA-08 YIAElectropharmacological characterization of anti-atrial fibrillatory drug
vernakalant using the isoflurane-anesthetized dogs
Ai Goto1, Ryuichi Kambayashi2, Hiroko Izumi-Nakaseko1,2, Akio Matsumoto3, Yoshinori Takei1,2,
Shinichi Kawai4, Atsushi Sugiyama1,2,3,4
1

Dept. Pharmacol., Grad. Sch. Med., Toho Univ., 2Dept. Pharmacol., Faculty. Med., Toho Univ.,3Dept. Aging
Pharmacol., Faculty. Med., Toho Univ.,4Dept. Inflammation & Pain Control Research, Faculty. Med., Toho Univ.

Copyright © The Japanese Pharmacological Society1-YIA-09

YIA
2+

Significant role of L-type Ca channels for arrhythmic trigger of druginduced long QT syndrome assessed in the acute atrioventricular blockrabbitSatoshi Kawakami, Mihoko Nagasawa-Hagiwara, Kazuhiro Takada, Yuki Ishimaru,
Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara
Dept. Pharmacol. Therap., Fac. Pharmaceut. Sci. Toho Univ.

Copyright © The Japanese Pharmacological Society1-YIA-10 YIA
Effect of TMEM182, a novel membrane protein, on muscle differentiation
Hirofumi Morihara, Soichiro Furutani, Shigeo Wakabayashi, Michio AsahiDiv. Pharmacol., Sch. Med. Osaka Med. Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society1-YIA-11 YIA
Chronic social stress alters synaptic central metabolism for depression
Hirotaka Nagai1, Midori Nagai1, Chisato Numa1, Tomomi Yamashita2, Yusuke Kawashima3,
Nobuhiko Ohno4,5, Yosky Kataoka6,7, Shuuichi Shimma8,9, Yuko Mimori-Kiyosue10, Taro Kato2,
Tomoyoshi Soga11, Tomoyuki Furuyashiki1
1

Kobe Univ Grad Sch Med Div Pharmacol, 2Pharmacol Res Unit Sumitomo Dainippon Pharma, 3Dep Appl
Genomics Kazusa DNA Res Inst, 4Div Histol Cell Biol Dep Anat Jichi Med Univ, 5Div Ultrastruct Res Natl Inst
Physiol Sci, 6Multi-Modal Microstruct Anal Unit Riken-JEOL Collab Ctr, 7Lab Cell Funct Imaging RIKEN Ctr
Biosyst Dynamics Res, 8Dep Biotechnol Grad Sch Eng Osaka Univ, 9Osaka Univ Shimadzu Anal Innov Lab, 10Lab
Mol Cellular Dynamics RIKEN Ctr Biosyst Dynamics Res, 11Inst Adv Biosci Keio Univ

Copyright © The Japanese Pharmacological Society1-YIA-12 YIA
Involvement of increased kynurenic acid through downregulation of
kynurenine-3-monooxygenase in depressive-like behavior and dysregulationof hypothalamic-pituitary-adrenal axis induced by chronic unpredictablemild stress
Masaya Hasegawa1, Akihiro Mouri1,4, Kazuo Kunisawa1, Hisayoshi Kubota1, Hitomi Kurahashi1,
Aika Kosuge1, Yasuko Yamamoto2, Kuniaki Saito2,3,4, Toshitaka Nabeshima3,41

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Uni., 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.,
4NPO. J-DO

Copyright © The Japanese Pharmacological Society1-YIA-13 YIA
A selective delta opioid receptor agonist, KNT-127, exerts an antidepressantlike effect and facilitates neuronal excitability in the mouse infralimbic
prefrontal cortex via PI3K-mTOR signaling
Toshinori Yoshioka1, Daisuke Yamada1, Keita Iio2, Hiroshi Nagase2, Akiyoshi Saitoh1
1Lab. Pharmacol., Fac. Pharmaceut. Sci., Tokyo Univ. of Science, 2Med. Chem., IIIS, Univ. of Tsukuba

Copyright © The Japanese Pharmacological Society1-YIA-14 YIA
Hemispheric asymmetry in chronic stress-induced microglial responses
Kazutoshi Matsushita, Masayuki Taniguchi, Tomoyuki Furuyashiki
Div. Pharmacol., Grad. Sch. Med., Kobe Univ.

Copyright © The Japanese Pharmacological Society1-YIA-15 YIA
Downregulation of astrocytic connexin43 potentiates the antidepressantinduced brain-derived neurotrophic factor expression
Tokunaga Nozomi, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka
Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society1-YIA-16 YIA
The role of progranulin on cardiac remodeling after myocardial infarction
Takahiro Sasaki1, Shinsuke Nakamura1, Masamitsu Shimazawa1,2, Hideaki Hara1,2
1

Mol. Pharmacol., Dept. Biofunc. Eval., Gifu Pharm. Univ., 2Lab. Collabo. Res. Innov. Drug Disc., Gifu Pharm.
Univ.

Copyright © The Japanese Pharmacological Society1-YIA-17 YIA
CaMKII inhibition prevent Doxorubicin-induced mitochondrial dysfunction,
independent from Drp1 and MCU.
Kurniawan Priyono Agung, Junichiro Miake, Yoshinori Ichihara, Tatsuya Sawano, Keiko Nagata,
Takeshi Imamura
1

Copyright © The Japanese Pharmacological Society1-YIA-18 YIAIron derived from ferritinophagy induces cardiomyocyte death and heart
failure in mice
Ito Jumpei1,2, Kinya Otsu2, Michio Asahi11Dept. Pharmacol., Fac. Med., Osaka Medical and Pharmaceutical University, 2Sch. Card. Med. and Sci., King’s
College London British Heart Foundation Centre of Excellence

Copyright © The Japanese Pharmacological Society1-YIA-19 YIA
Endogenous YAP activity potentiates GSK3 inhibitors-induced proliferationof cardiomyocytes.
Yusuke Kametani1, Shota Suzuki1, Ayaka Umeda1, Kosuke Nishinaka1, Shota Tanaka1,
Makiko Maeda2, Yoshiaki Okada1, Masanori Obana1,3, Yasushi Fujio1,3
1

Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University,
Laboratory of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka
University, 3Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary
Research Initiatives (OTRI), Osaka University
2

Copyright © The Japanese Pharmacological Society1-YIA-20 YIA
The Interaction of the p300 with the BRG1 Increases the Acetylation levels of
the H3K122 in Heart Failure
Funamoto Masafumi1,2,3, Yoichi Sunagawa2,3, Yasufumi Katanasaka2,3, Kana Shimizu2,3,
Satoshi Shimizu2,3, Koji Hasegawa2,3, Yasumasa Ikeda1, Tatsuya Morimoto2,3
1

Dept. Pharmacol. Grad. Biomed. Sci. Tokushima Univ., 2NHO Kyoto Ctr. Div. Translational Res.,3Dept. Mol. Med.
Pharmacol. Univ. Shizuoka.

Copyright © The Japanese Pharmacological Society1-YIA-21 YIA
Novel prevention target of peritoneal deterioration caused by peritoneal
dialysis
Mihara Taiki
Dept. of Vet. Pharmacol., Grad. Sch. Of Agri. & Life Sci., The Univ. of Tokyo

Copyright © The Japanese Pharmacological Society1-YIA-22 YIA
Efficacy of Keap1-Nrf2 protein-protein interaction inhibitor forglomerulosclerosis in mouse model of chronic kidney disease
Shota Kaseda1,2, Yuya Sannomiya1, Jun Horizono1, Jun Kuwazuru1, Mary Ann Suico1,
Sayaka Ogi3, Ryoko Sasaki1, Hidetoshi Sunamoto3, Hirohiko Fukiya3, Hayato Nishiyama3,
Misato Kamura1,2, Futoshi Nara3, Tsuyoshi Shuto1, Kazuhiro Onuma3, Hirofumi Kai1,21

Dept. Molecular Medicine. Kumamoto Univ., 2HIGO program Kumamoto Univ., 3Pharmaceut Res Lab. UBE Ind
Ltd.

Copyright © The Japanese Pharmacological Society1-YIA-23 YIA
Increased OASIS in podocytes contributes to the disruption of kidney
homeostasis
Yoshiaki Miyake1, Masanori Obana1,2,3,4, Ayaha Yamamoto1, Shota Tanaka1, Makiko Maeda5,
Yoshiaki Okada1, Kazunori Imaizumi6, Katsuhiko Asanuma7, Yasushi Fujio1,2
1

Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University,
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research
Initiatives (OTRI), Osaka University, 3Global Center for Medical Engineering and Informatics (MEI), Osaka
University, 4Radioisotope Research Center, Institute for Radiation Sciences, Osaka University, 5Laboratory ofClinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University,
6
Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University, 7Department ofNephrology, Graduate School of Medicine, Chiba University
2

Copyright © The Japanese Pharmacological Society1-YIA-24 YIA
Stathmin participates in antiproliferative effects of eribulin inleiomyosarcoma cells
Mana Azumi, Mikihiro Yoshie, Nami Nakachi, Kazuya Kusama, Kazuhiro Tamura
Dept. Endocrine Pharmacol. Tokyo Univ. Pharm. Life Sci.

Copyright © The Japanese Pharmacological Society1-YIA-25 YIA
Effect of filtrated bone marrow derived mesenchymal stem cell lysate on
erectile function in erectile dysfunction model rat with cavernous nerve
injuryTaiki Mori1, Yuji Hotta1, Tomoya Kataoka2, Seiji Matsumoto3,4, Tokunori Yamamoto3,4,5,
Kazunori Kimura1,2
1

Dept. Hospital Pharm., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2Dept. Clinical Pharm., Grad. Sch. Med. Sci.,
Nagoya City Univ., 3Ctr. Adv. Res. Educ., Asahikawa Med. Univ.,4Clin. Res. Support Ctr., Asahikawa Med. Univ.
Hosp., 5Lab. Clin. Application of Adipose-Derived Regenerative Cells, Grad. Sch. Med., Nagoya Univ.

Copyright © The Japanese Pharmacological Society1-YIA-26 YIAFNIII14, an integrin-inactivating peptide, inhibits MUC5AC exocytosis in NCIH292 airway epithelial cells
Hiromi Moriya, Kazuhito Murakami, Fumio Fukai, Yoichiro Isohama
Faculty of Pharmaceutical Sciences, Tokyo University of Science

Copyright © The Japanese Pharmacological Society1-YIA-27 YIA
Basic study to evaluate the risk of liver injury of acetaminophen use inNiemann-Pick disease type C
Namba Nanami1,2, Miori Yukizaki1, Yuki Kondo1, Yusei Yamada1,3, Toru Takeo4,
Naomi Nakagata4, Takumi Era5, Taishi Higashi6,7, Keiichi Motoyama6, Hidetoshi Arima8,
Takahiro Seki9, Yuki Kurauchi9, Hiroshi Katsuki9, Muneaki Matsuo10, Katsumi Higaki11,
Tetsumi Irie12, Yoichi Ishitsuka1
1

Dept. Clin. Chem. Info. Kumamoto Univ., 2Prog. Professional Development fellowship Health Sci. S-HIGO
Kumamoto Univ., 3Dept. Pharm. Miyazaki Med. Coll. Hosp., 4Div. Reproductive Eng. Ctr. Anim. Resour. Develop.
Kumamoto Univ., 5Dept. Cell Modulation Inst. Mol. Embryology Genetics Kumamoto Univ., 6Dept. PhysicalPharmaceut. Kumamoto Univ., 7Priority Organization for Innobation and Excellence Kumamoto Univ., 8Lab.
Evidence-cased Pharmacotherap. Daiichi Univ. Pharm., 9Dept. Chemico-Pharmacol. Sci. Kumamoto Univ., 10Dept.
Pediatrics Faculty Med. Saga Univ., 11Res. Initiative Ctr. Organization Res. Initiative Promotion Tottori Univ.,
12
Dept. Pharmaceut. Packaging Global Nat. Products Chem. Res. Ctr.

Copyright © The Japanese Pharmacological Society1-YIA-28 YIAMultiplex immunohistochemistry and image cytometry reveals an impact ofcochlear resident macrophages on Cisplatin-induced hearing loss
Mai Bedeir, Yuzuru Ninoyu, Takashi Nakamura, Takahiro Tsujikawa, Shigeru Hirano, Bedeir
Kyoto Prefectural Uni. of Med. Dept. of Otolaryngology-Head and Neck Surgery

Copyright © The Japanese Pharmacological Society1-YIA-29 YIA
Nox3-derived superoxide in cochleae induces acquired sensorineural
hearing loss
Mohri Hiroaki1,2,3, Yuzuru Ninoyu1, Sakaguchi Hirofumi2, Naoaki Saito1, Takehiko Ueyama1
1Lab. of Mol. Pharmacol., Biosignal Research Center, Kobe Univ.,2Dept. of Otolaryngology-Head and Neck
Surgery, Kyoto Prefectural Univ. of Med., 3Dept. of Otolaryngology, Red Cross Kyoto Daiichi Hosp.

Copyright © The Japanese Pharmacological Society1-YIA-30 YIA
Evaluation of in vitro antibacterial activities of therapeutic drugs against
Clostridioides difficile, and measurement of fecal concentrations in
Clostridioides difficile infection mouse models.
Sho Tashiro, Yuki Mizukami, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto
Keio Univ., Fac. Pharm., Div. Pharmacod.

Copyright © The Japanese Pharmacological Society1-YIA-31

YIA

Copyright © The Japanese Pharmacological Society1-YIA-32 YIA
Effect of advanced glycation end products on STING pathway inmacrophage
Takashi Nishinaka1, Omer Faruk Hatipoglu1, Hidenori Wake1, Masahiro Watanabe2,
Takao Toyomura2, Masahiro Nishibori3, Hideo Takahashi11Dept. Pharmacol., Facul. Med., Kindai Univ., 2Dept. Pharmcol., Sch. Pharmacy, Shujitsu Univ., 3Sch. Med. Dent.
Pharm. Sci., Okayama Univ.

Copyright © The Japanese Pharmacological Society1-YIA-33 YIA
Mitofusin1 regulates innate immune responses by inhibiting theaccumulation of mitochondrial DNA mutation in sepsis
Kiichi Nakahira1,2, Chimere Ezuma2, Kuei-Pin Chung2,3, Weilin Xu4, Elizabeth Sanchez1, ChiaLang Hsu5, Xiaoxian Guo4, Keith Mcconn2, Lisa Torres2, Xuan Yang4, Yiqin Wang4,
Karen Kobayashi1, Masanori Yoshizumi1, Zhenglong Gu4, Augustine Choi2
1

Department of Pharmacology, Nara Medical University, 2Division of Pulmonary and Critical Care Medicine,
Department of Medicine, Weill Cornell Medicine, 3Department of Laboratory Medicine, National Taiwan
University, 4Division of Nutritional Sciences, Cornell University, 5Department of Medical Research, National
Taiwan University

Copyright © The Japanese Pharmacological Society1-YIA-34 YIA
Analysis of the brain-periphery immune system by the specific manipulationof stress-related neurons
Sara Yoshida1, Yusuke Hamada1,2, Daisuke Sato1, Michiko Narita2,3, Akihiro Yamanaka4,
Naoko Kuzumaki1,2, Minoru Narita1,21

Dept. Pharmacol., Hoshi Univ., 2Div. Pathophysiol., Natl. Cancr Ctr. Res. Inst., 3Inst. of Med. Sci., Tokyo Med.
Univ., 4Dept. Neurosci. Ⅱ, RIEM, Nagoya Univ.

Copyright © The Japanese Pharmacological Society1-YIA-35 YIA
Anti-asthmatic effect of nanoliposomal ceramides in a mouse model
Sakae Harumi1, Kentaro Yuasa2, Saki Manabe2, Mark Kester3, Masaya Matsuda2,
Kazuyuki Kitatani2, Takeshi Nabe2
1

Lab. of Immunopharmacol., Grad. Sch. of Pharm. Sci., Setsunan Univ., Osaka, Japan, 2Lab. of Immunopharmacol.,Fac. of Pharm. Sci., Setsunan Univ., Osaka, Japan, 3Dept. of Pharmacol., Univ. of Virginia.

Copyright © The Japanese Pharmacological Society1-YIA-36 YIA
The automated scratching detection method of mice using artificial
intelligence
Koji Kobayashi1, Seiji Matsushita1, Naoyuki Shimizu1, Sakura Masuko1, Masahito Yamamoto2,
Takahisa Murata1
1

Dept. of Animal Radiology, The Univ. of Tokyo,2Autonomous Systems Engineering Laboratory, Hokkaido Univ.

Copyright © The Japanese Pharmacological Society1-YIA-37 YIA
P2X4 receptor signaling potentiate Mas-relate G protein-coupled receptor B2
induced mast cell activation.
Kazuki Yoshida, Kousuke Obayashi, Syouta Tanihara, Tomoki Miyashita, Masaaki Ito,
Isao Matsuoka
Lab. Pharmacol., Fact. Pharm, Takasaki Univ. Health and Welfare

Copyright © The Japanese Pharmacological Society1-YIA-38 YIA
The role of PGD2/CRTH2 signaling in allergic reaction
Misato Kida, Tatsuro Nakamura, Nanae Nagata, Takahisa Murata
Grad. Agr. & Life Sciences. Tokyo Univ.

Copyright © The Japanese Pharmacological Society1-SS-01 Student Sessions
Spontaneous and local ATP release in astrocytes revealed by spatiotemporal
analysis using two-photon microscopy
Hatashita Yoshiki1, Zhaofa Wu2, Yulong Li2, Takafumi Inoue1
1

Life Sci. and Med. Biosci., Waseda Univ., 2Sch. of Life Sci., Peking Univ.

Copyright © The Japanese Pharmacological Society1-SS-02 Student Sessions
Regulation of neuron-astrocyte communication by microglia
Suzuki Hideaki1,2, Eiji Shigetomi1,2, Yukiho Hirayama1, Yukari Takahashi3, Kazuhiro Ikenaka4,
Kenji Tanaka5, Husao Katou3, Haruhiko Bito6, Schuichi Koizumi1,2
1

Dept Neuropharmacol, Interdiscipl Grad Sch Med, Univ Yamanashi, 2Yamanashi GLIA Center, 3Dept Neurosci,
Jikei Univ, 4Div Neurobiol and Bioinfo, NIPS, 5Dept Neuropsych, Keio Univ Sch Med, 6Dept Neurochem, Grad Sch
Med, Univ Tokyo

Copyright © The Japanese Pharmacological Society1-SS-03 Student Sessions
Microglia repopulation ameliorates the pathology of Alexander disease, theprimary astrocyte disease.
Kenji Kobayashi1,2, Eiji Shigetomi1,2, Bijay Parajuli1,2, Yuto Kubota1,2, Kozo Saito1,2, Kenji Tanaka3,
Kazuhiro Ikenaka4, Schuichi Koizumi1,2
1

Dept Neuropharmacol, Interdiscipl Grad Sch Med, Univ Yamanashi, 2GLIA center, Interdiscipl Grad Sch Med,
Univ Yamanashi, 3Dept Neuropsych, Keio Univ Sch Med., 4Div Neurobiol and Bioinfo, NIPS

Copyright © The Japanese Pharmacological Society1-SS-04 Student Sessions
Contribution of oligodendrocyte precursor cells to disease severity in amouse model of multiple sclerosis
Kana Ohashi, Nagisa Matsuo, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ.

Copyright © The Japanese Pharmacological Society1-SS-05 Student Sessions
Lack of P2Y1 receptors in Müller cells causes a glaucoma-like phenotype
Hamada Kentaro1, Yoichi Shinozaki1,2, Kazuhiko Namekata3, Nobuhiko Ohno4,5,
Kenji Kashiwagi6, Schuichi Koizumi1,2
1

Dept. Neuropharmacol., Interdiscip. Grad. Sch. Med. Univ. Yamanashi,2GLIA Center, Univ Yamanashi,3Vis. Res.
Project, Tokyo Metr. Inst. Med. Sci.,4Div. Ultrasct.Res., Natl. Inst. Physiol. Sci., 5Dept. Anat., Jichi Med. Univ.,
6
Dept. Ophthalmol., Interdiscp. Grad. Sch. Med. Univ. Yamanashi

Copyright © The Japanese Pharmacological Society1-SS-06 Student Sessions
Developmental synchronous firing modulates synaptic connectivity
Kashima Tetsuhiko1, Yuji Ikegaya1,2,3
1

Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo, 2Inst AI Beyond, Univ Tokyo, 3CiNet

Copyright © The Japanese Pharmacological Society1-SS-07 Student Sessions
Localization of Desmoplakin, an adhesion-related molecule, in the dentate
gyrus of mouse hippocampus
Akinori Takayama, Chinai Saiaka, Kensiro Uemura, Nana Koyama, Jin Nakatani,
Toshinori Sawano, Hidekazu Tanaka
Ritsumeikan, Life sci,Pharmacol lab

Copyright © The Japanese Pharmacological Society1-SS-08 Student Sessions
Dynamic changes in orexin activities associated with reward-based
motivative behavior
Dong Yutao1, Hiroyuki Mizoguchi1,2, Akihiro Yamanaka3, Kiyofumi Yamada1
1

Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University graduate School of
Medicine, 2Medical Interactive Research and Academia Industry Collaboration Center, Research Institute ofEnvironmental Medicine, Nagoya University, 3Department of Neuroscience Ⅱ, Research Institute of Environmental
Medicine, Nagoya University

Copyright © The Japanese Pharmacological Society1-SS-09 Student Sessions
The effect of neurotrophin-3 overexpression on adult hippocampal
neurogenesis
Kasakura Nanami, Yuka Murata, Ryo Tabata, Ryota Someya, Eri Segi-Nishida
Dept. of Biol. Sci. & Tech., Fac. of Adv. Tech., Tokyo Univ. of Sci., Tokyo, Japan

Copyright © The Japanese Pharmacological Society1-SS-10 Student Sessions
An in vitro model of thalamocortical and corticothalamic interactions using
human induced pluripotent stem cells
Masatoshi Nishimura1, Tomoki Kodera1, Fumitaka Osakada1,2,3
1Lab. Cell. Pharmacol., Grad. Pharm. Sci., Nagoya Univ., 2Lab. Neural Info. Proc., Inst. Adv. Res., Nagoya Univ.,
3
NLS, Inst. Inn. Fut. Soc., Nagoya Univ.

Copyright © The Japanese Pharmacological Society1-SS-11 Student Sessions
Regulatory mechanism of stress sensitivity by Shati/Nat8l in the dorsal
striatum
Hajime Miyanishi1, Shin-ichi Muramatsu2,3, Atsumi Nitta1
1

Dept. Pharmaceut therap & neuropharmacol, Fac. Pharmaceut Sci, Grad. Sch. Med & Pharmaceut Sci, Toyama
Univ, 2Div. Neuro Gene Therap, Open Innov Ctr, Jichi Med Univ,3Ctr. Gene & Cell Therap, Inst. Med Sci, Tokyo
Univ

Copyright © The Japanese Pharmacological Society1-SS-12 Student Sessions
The L-DOPA receptor GPR143 in the indirect pathways regulates an anxietylike behavior in mice
Tajika Rei1,2, Daiki Masukawa2, Hiraku Uchimura2, Yoshio Goshima2
1

Dept. Biol., Kitasato Univ. Sch. Sci., 2Dept. Mol. Pharmacol. Neurobiol., Yokohama City Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society1-SS-13 Student Sessions
Roles of synaptic mitochondrial regulations for stress susceptibility
Chisato Numa1, Hirotaka Nagai1, Midori Nagai1, Tomomi Yamashita2, Yusuke Kawashima3,
Nobuhiko Ohno4,8, Yosky Kataoka5,6, Yuko Mimori-Kiyosue7, Taro Kato2, Tomoyuki Furuyashiki1
1

Kobe Univ. Dept. Med. Div. Pharmacol., 2Sumitomo Dainippon Pharma Pharmacol. Res. Unit, 3Kazusa DNA Res.
Inst. Dept. of Appl. Genomics, 4Jichi Med. Univ. Div. Hist. & Cell Biol. Dept. Anat., 5RIKEN-JEOL Collaboration
Center Multi-Modal Microstructure Analysis Unit, 6RIKEN BDR Lab. Cell. Funct. Img., 7RIKEN BDR Lab. Mol. &Cell. Dyn., 8National Inst. for Physiological Sci. Div. of Ultrastructural Res.

Copyright © The Japanese Pharmacological Society1-SS-14 Student Sessions
Possible involvement of hypothalamic paraventricular nucleus PACAP inchronic pain-induced negative emotional responses in mice
Hashiguchi Kohei1, Yuki Kambe2, Mitsutaka Sugimura1, Takashi Kurihara2, Atsuro Miyata2
1

Dept. Dent. Anesthesiol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ., 2Dept. Pharmacol., Grad. Sch. Med. Dent.
Sci., Kagoshima Univ.

Copyright © The Japanese Pharmacological Society1-SS-15 Student Sessions
A Novel PACAP receptor PAC1 antagonist exhibits fast and lasting antidepressant effectYusuke Shintani1, Atsuko Hayata-Takano1,2, Yui Yamano1, Manato Ikuta1, Rei Takashita1,
Ichiro Takasaki3, Takashi Kurihara4, Hitoshi Hashimoto1,2,5,6,7
1

Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University,
Suita, Japan., 2Molecular Research Center for Children’s Mental Development, United Graduate School of Child
Development, Osaka University, Suita Japan, 3Department of Pharmacology, Graduate School of Science andEngineering, University of Toyama, Toyama, Japan, 4Department of Pharmacology, Graduate School of Medical
and Dental Sciences, Kagoshima University, Kagoshima, Japan, 55Division of Bioscience, Institute for Datability
Science, Osaka University, Suita, Japan, 6Transdimensional Life Imaging Division, Institute for Open andTransdisciplinary Research Initiatives, Osaka University, Suita, Japan, 7Department of Molecular Pharmaceutical
Science, Graduate School of Medicine, Osaka University, Suita, Japan.

Copyright © The Japanese Pharmacological Society1-SS-16 Student Sessions
Deep learning of mother-infant interactions in V1b Vasopressin receptor
knockout mice
Chortip Sajjaviriya, Casmad Fujianti, Morio Azuma, Hiroyoshi Tsuchiya, Taka-aki Koshimizu
Dep. Mol. Pharmacol. Jichi Med. Univ.

Copyright © The Japanese Pharmacological Society1-SS-17 Student Sessions
Treatment with lysophosphatidic acid LPA improves depressive behaviors
in neuropsychiatric lupus erythematosus (NPSLE) model mice through LPA
receptor
Wataru Nagata1, Akiho Koizumi1, Keiichi Nakagawa1, Sayaka Takahashi1, Keiko Fukasawa3,
Mari Goto3, Yasushi Sato2, Toshiaki Ishizuka1
1

Department of Pharmacology, National Defense Medical College, 2Department of Biochemistry, National Defense
Medical College, 3Human Life Innovation Development Research Organization,Ochanomizu University

Copyright © The Japanese Pharmacological Society1-SS-18 Student Sessions
Activation of δ-opioid receptors in the infralimbic cortex and amygdala
facilitates contextual fear extinction in mice.
Ayako Kawaminami1, Daisuke Yamada1, Shoko Yanagisawa1, Motoki Shirakata1, Keita Iio2,
Hiroshi Nagase2
1

Lab Pharmacol, Fac Pharm Sci, Tokyo Univ of Science, 2IIIS, Univ of Tsukuba

Copyright © The Japanese Pharmacological Society1-SS-19 Student Sessions
Involvement of GPR143, an L-DOPA receptor, in haloperidol-induced
extrapyramidal symptoms
Masami Arai, Daiki Masukawa, Satoshi Kitamura, Momoyo Otaki, Yoshio Goshima
Dept. Mol. Pharmacol. Neurobiol., Yokohama City Univ.

Copyright © The Japanese Pharmacological Society1-SS-20 Student Sessions
Effect of hachimijiogan on social cognitive dysfunction and arginase-1
expression in SAMP8 mice
Yasutomo Matsumoto1, Kanako Mihara1, Ayano Ise1, Takuya Watanabe1,2, Kaori Kubota1,2,
Shutaro Katsuravayashi1, Katsunori Iwasaki1,21

Dept. Neuropharmacol. Fukuoka Univ., 2Inst. Aging & Brain Sci. Fukuoka Univ.

Copyright © The Japanese Pharmacological Society1-SS-21 Student Sessions
Mirogabalin inhibits paclitaxel-induced mechanical allodynia in mice byacting on α2δ-1 subunit in the spinal dorsal horn
Yamada Karin, Masahito Sawahata, Toshiaki Kume, Daisuke Uta
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of
ToyamaCopyright © The Japanese Pharmacological Society1-SS-22 Student Sessions
Pregabalin as a pathogenic mechanism-based therapeutic strategy for dry
eye-induced chronic ocular pain
Yuto Tei1,2, Yoshinori Mikami1, Masanori Ito1, Taichiro Tomida1, Daisuke Ohshima1, Yuichi Hori2,
Satomi Adachi-Akahane11Dept. Physiol. Fac. Med., Toho Univ., 2Dept. Ophthalmology. Fac. Med., Toho Univ.

Copyright © The Japanese Pharmacological Society1-SS-23 Student Sessions
Inhibitory effect of mirogabalin for chronic itch in atopic dermatitis modelmice
Matsuda Kosuke, Masahito Sawahata, Toshiaki Kume, Daisuke Uta
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of
ToyamaCopyright © The Japanese Pharmacological Society1-SS-24 Student Sessions
Role of astrocytes in dysfunction of spinal dorsal horn neurons crucial forneuropathic allodynia
Daichi Sueto1, Tadayuki Ishibashi1,2, Yu Yoshikawa1, Ken Yamaura2, Makoto Tsuda1
1

Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu
University, 2Department of Anesthesiology and Critical Care Medicine, Graduate School of Medicine, Kyushu
University

Copyright © The Japanese Pharmacological Society1-SS-25 Student Sessions
Involvement of noradrenergic signaling in stress-induced analgesia
Sawako Uchiyama1, Kohei Yoshihara1, Riku Kawanabe1, Keisuke Koga2, Makoto Tsuda1
1

Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu
University, 2Department of Neurophysiology, Hyogo College of Medicine

Copyright © The Japanese Pharmacological Society1-SS-26 Student Sessions
Cellular stress-induced formation of RNA G-quadruplexes accelerates αSynuclein aggregation
Kohei Maeda1,2, Yasushi Yabuki1,2, Sefan Asamitsu2, Kazuya Matsuo2, Tomohiro Mizobata3,
Yasushi Kawata3, Norifumi Shioda1,2
1Sch. Pharm., Kumamoto Univ, 2Dept. Geno. Neurol., IMEG., Kumamoto Univ, 3Dept. Chem. & Biotech., Grad. Sch.
Eng., Tottori Univ

Copyright © The Japanese Pharmacological Society1-SS-27 Student Sessions
Therapeutic targeting expanded DNA using cyclic pyrrole-imidazolepolyamide in CAG/CTG triplet repeat neurological diseases.
Kosuke Kawakubo1, Susumu Ikenoshita1, Kazuya Matsuo1, Sefan Asamitsu1, Yasushi Yabuki1,
Hiroshi Sugiyama2, Norifumi Shioda1
1

Dept. Genomic Neurology, IMEG., Kumamoto Univ., 2Dept. Chem., Grad. Sch. Sci., Kyoto Univ.

Copyright © The Japanese Pharmacological Society1-SS-28 Student Sessions
Regulation of function and metabolism of amyloid-beta precursor protein by
Semaphorin3A-PlexinA signaling
Takumi Sekiguchi1, Takashi Sakurai1, Naoya Yamashita1,21

Dept. of Cell and Mol Pharmacol., Juntendo Univ., Sch. Med., 2Dept. of Applied Biosci., Kanagawa Inst. of Tech.

Copyright © The Japanese Pharmacological Society1-SS-29 Student Sessions
Changes in the expression of fatty acid-binding protein subtype 3 (FABP3) inthe median eminence of mouse brain with pain.
Dan Tachibana, Kazuo Nakamoto, Shogo Tokuyama
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University.

Copyright © The Japanese Pharmacological Society1-SS-30 Student Sessions
TAFIa/carboxypeptidase B generated by the thrombomodulin/thrombin
system prevents oxaliplatin-induced peripheral neuropathy throughinactivation of complement component C5a
Maruo Kengo1, Maho Tsubota1, Kazuki Tajima1, Fumiko Sekiguchi1, Mashiro Nishibori2,
Tatsuro Minami3, Akitoshi Ito3, Atsufumi Kawabata1,3
1Lab. Pharmacol. Pathophysiol., Kindai Univ., 2Dept. transl. Res. Drug Dev., Okayama Univ. Grad. Sch. Med. Dent.
Pharmaceut. Sci., 3Lab. Pharmacol., Pharmaceut Res Cent, Asahi Kasei Pharma Co.

Copyright © The Japanese Pharmacological Society1-SS-31 Student Sessions
Simvastatin attenuates cardiac remodeling via Hsp90 inhibition.
Manami Uchida, Tetsuro Marunouchi, Kyo Fujita, Emi Yano, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

Copyright © The Japanese Pharmacological Society1-SS-32 Student Sessions
A PRMT5 selective inhibitor EPZ015666 inhibits pressure overload-induced
left ventricular dysfunction through the suppression of cardiac hypertrophyand fibrosis
Mogi Hyuma1, Yasuhumi Katanasaka1,2,3, Taiki Honda1, Yoichi Sunagawa1,2,3, Kana Shimizu1,
Satoshi Shimizu1, Koji Hasegawa1,2, Tatsuya Morimoto1,2,3
1Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, 2Division ofTranslational Research, National Hospital Organization Kyoto Medical Center,3Shizuoka General Hospital

Copyright © The Japanese Pharmacological Society1-SS-33 Student Sessions
Differences in the onset of heart failure due to aging and gender: an analysis
using a mouse model of heart failure
Hyeree Kim1, Fujimi Kudo2, Hiroyuki Takano1, Ichiro Manabe2
1Dept. Biomol. Cardiovasc. Pharmacol. Chiba Univ., 2Dept. Sys. Med. Chiba Univ.

Copyright © The Japanese Pharmacological Society1-SS-34 Student Sessions
The curcumin analog, GO-Y022 suppressed the pressure overload-induced
systolic dysfunction at a lower concentration than curcumin
Hirako Yuta1, Kana Shimizu1,2, Masahumi Funamoto1,2, Yuto Kawase1, Hanhao Wu1,
Yoichi Sunagawa1,2,3, Yasuhumi Katanasaka1,2,3, Satoshi Shimizu1,2, Hiroyuki Shibata4,
Koji Hasegawa1,2, Tatsuya Morimoto1,2,3
1Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, 2Division ofTranslational Research, National Hospital Organization Kyoto Medical Center,3Division of Clinical research,
Shizuoka General Hospital, 4Division of Clinical research, University of Akita

Copyright © The Japanese Pharmacological Society1-SS-35 Student Sessions
Exploration of preventive drugs for sunitinib-induced heart failure utilizing
large-scale medical database
Sakamoto Yoshika1, Nanami Tomochika1, Hirofumi Hamano2, Mitsuhiro Goda1,3,
Takahiro Niimura3, Fuka Aizawa3, Kenta Yagi2, Akihito Nakamura3, Shiori Nishiuchi1,3,
Yuki Izawa-Ishizawa4, Yoshito Zamami1,5, Keisuke Ishizawa1,31

Dept. Clin. Pharmacol. & Therap., Tokushima Univ., 2Clin. Res. Ctr. Dev. Therap., Tokushima Univ. Hosp.,
Pharm., Tokushima Univ. Hosp., 4Dept. Pharmacol., Tokushima Univ., 5Pharm., Okayama Univ. Hosp.

3

Copyright © The Japanese Pharmacological Society1-SS-36 Student Sessions
Carvedilol ameliorated UK14304-induced vascular relaxation response via
AMPK in diabetic mice aortas
Kanami Okudaira, Kumiko Taguchi, Ayaka Kemmoku, Keiri Tou, Kurumi Kameyama,
Misaki Kikukawa, Daiki Sekine, Tetsuya Sugishima, Takayuki Matsumoto, Tsuneo Kobayashi
Dept. Physiol. Morphol. Inst. Med. Chem. Hoshi Univ.

Copyright © The Japanese Pharmacological Society1-SS-37 Student Sessions
The effect of Eucommia ulmoides leaf extract on aortic dissection onset inmice
Koji Miyata1, Yuki Izawa-Ishizawa2, Masateru Kondo1,3, Kaito Tsujinaka1,3, Kohei Omine1,
Honoka Nishi1, Fuka Aizawa1,3, Hirofumi Hamano4, Kenta Yagi4, Yoshito Zamami5,
Mitsuhiro Goda1,3, Keisuke Ishizawa1,31

Dept. Clin. Pharmacol. & Therap., Tokushima Univ., 2Dept. Pharmacol., Tokushima Univ., 3Pharm., Tokushima
Univ. Hosp., 4Clin. Res. Ctr. Dev. Therap., Tokushima Univ. Hosp.,5Pharm., Okayama Univ. Hosp.

Copyright © The Japanese Pharmacological Society1-SS-38 Student Sessions
Effects of Suramin administration on hemodynamics during myocardialischemia induced by anaphylaxis in rats.
Koyamatsu Haruhi, Sho Okawa, Seiichiro Kano
Dept. of Life Sci. Faculty of Pharmaceut. Sci. , Hokkaido Univ. of Sci.

Copyright © The Japanese Pharmacological Society1-SS-39 Student Sessions
Assessment of BMS-986094-induced chronic cardiotoxicity using human iPS
cells-derived cardiomyocytes
Yanagida Shota1,2, Ayano Satsuka2, Sayo Hayashi2, Atsushi Ono1, Yasunari Kanda1,2
1Div. Pharmaceut. Sci, Grad Sch Med., Dent. and Pharmacet. Sci, Okayama Univ., 2Div. Pharmacol. NIHS

Copyright © The Japanese Pharmacological Society1-SS-40 Student Sessions
Effects of Tanshinone VI on the differentiation from cardiac stem cells into
cardiomyocytes
Mayu Motoi, Minami Ikoshi, Emi Yano, Tetsuro Marunouchi, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

Copyright © The Japanese Pharmacological Society1-SS-41 Student Sessions
Elucidation of the onset mechanism of exercise-induced acute kidney injury
using renal hypouricemia type-1 model mice and the effects of xanthineoxidoreductase inhibitor
Takuji Hosoya1,3, Shunya Uchida2, Shigeru Shibata2, Naoko Tomioka.H1, Makoto Hosoyamada1
1

Dept. Hum. Physiol. Pathol., Grad. Sch. Pharmaceut. Sci., Teikyo Univ., 2Dept. Int. Med., Sch. Med., Teikyo Univ.,
3
Dept. Biol. Res., FUJI YAKUHIN CO., LTD.

Copyright © The Japanese Pharmacological Society1-SS-42 Student Sessions
Histamine H3 receptor expressed on pancreatic β-cells downregulate its
insulin secretion and proliferation
Kudomi Uta1, Takuro Matsuzawa1, Tadaho Nakamura2, Kazuhiko Yanai1, Takeo Yoshikawa1
1

Dept Pharmacol. Sch Med. Tohoku Univ, 2Tohoku Medical and Pharmaceutical University, Faculty of Medicine,
Division of Pharmacology

Copyright © The Japanese Pharmacological Society1-SS-43 Student Sessions
Analysis of aging-induced neural dysfunctions and their biological basis
Yamada Rui1, Hirotaka Nagai1, Chisato Numa1, Io Horikawa1, Midori Nagai1,
Yusuke Kawashima2, Tomoyuki Furuyashiki1
1

Division of Pharmacology, Graduate School of Medicine, Kobe University, 2Kazusa DNA Research InstituteCopyright © The Japanese Pharmacological Society1-SS-44 Student Sessions
Deletion of SIRT1 in the skeletal muscle causes suppression of autophagy
and muscle atrophy.
Nakashima Ryuta, Ryusuke Hosoda, Atsushi Kuno, Seidai Asakura, Naotoshi Iwahara,
Iyori Nojima, Yoshiyuki Horio
Department of Pharmacology, Sapporo Medical University School of Medicine, Sapporo, Japan

Copyright © The Japanese Pharmacological Society1-SS-45 Student Sessions
Comparison of the binding characteristics of [¹⁸F]SNFT-1 and other tau
imaging tracers to Alzheimer's disease pathology
Yokoyama Yuka1, Ryuichi Harada1, Lerdsirisuk Pradith2, Yuki Shimizu2, Yiqing Du1,
Yoichi Ishikawa2, Hiroyuki Arai3, Yukitsuka Kudo3, Syozo Furumoto2, Nobuyuki Okamura4,
Kazuhiko Yanai1
1

Department of Pharmacology, Tohoku University Graduate School of Medicine, 2Department of Geriatrics andGerontology, Institute of Development, Aging and Cancer, Tohoku University,3Cyclotron and Radioisotope Center,
Tohoku University, 4Divison of Pharmacology, Tohoku Medical and Pharmaceutical University

Copyright © The Japanese Pharmacological Society1-SS-46 Student Sessions
Examining the mechanisms underlying bladder fibrosis associated withinjured intrapelvic nerves in rats
Ryoya Kawata1, Yuji Hotta1, Nami Nakata1, Tomoya Kataoka2, Yoko Hibi1, Kazunori Kimura1,2
1

Dept. Hospital Pharm., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2Dept. Clinical Pharm., Grad. Sch. Med. Sci.,
Nagoya City univ.

Copyright © The Japanese Pharmacological Society1-SS-47 Student Sessions
Efficacy of filtered bone marrow stem cell lysate for overflow urinary
incontinence in model rats
Shibayama Maaya1, Yuji Hotta1, Tomoya Kataoka2, Seiji Matsumoto3, Tokunori Yamamoto4,
Kazunori Kimura1,2
1

Dept. Hospital Pharm., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2Dept. Clinical Pharm., Grad. Sch. Med. Sci.,
Nagoya City Univ., 3Cent. Adv. Res. Edu., Asahikawa Med. Univ., 4Dept. Neph., Grad. Sch. Med. Sci., Nagoya Univ.

Copyright © The Japanese Pharmacological Society1-SS-48 Student Sessions
Effects of sodium valproate on cisplatin-induced acute kidney injury
Toshihiko Yoshioka1,2, Mitsuhiro Goda1,2, Masaya Kanda1,2, Ami Yoshida1, Sayuri Itobayashi1,
Yugo Sugimoto1, Yuki Izawa-Ishizawa3, Kenta Yagi4, Fuka Aizawa2, Hirofumi Hamano4,
Naoto Okada2, Yoshito Zamami1,5, Keisuke Ishizawa1,21

Dept. Clin. Pharmacol. & Therap., Tokushima Univ., 2Pharm., Tokushima Univ. Hosp., 3Dept. Pharmacol.,Tokushima Univ., 4Clin. Res. Ctr. Dev. Therap., Tokushima Univ. Hosp.,5Pharm., Okayama Univ. Hosp.

Copyright © The Japanese Pharmacological Society1-SS-49 Student Sessions
Mechanisms of hydrogen sulfide-induced protective effect on rat bladderdysfunction induced by cyclophosphamide
Suo Zou1, Takahiro Shimizu1, Atsushi Kurabayashi2, Shogo Shimizu1, Hideaki Ono1,3,
Yohei Shimizu1,3, Yurika Hata1,3, Masaki Yamamoto4, Takaaki Aratake1,5, Youichirou Higashi1,
Motoaki Saito1
1

Dept. of Pharmacol., Kochi Med. Sci., Kochi Univ., 2Dept. of Pathol., Kochi Med. Sci., Kochi Univ., 3Centr. Innov.
and Translational Med., Kochi Med. Sci., Kochi Univ., 4Dept. of Ped., Kochi Med. Sci., Kochi Univ., 5Research
Fellow of JSPS

Copyright © The Japanese Pharmacological Society1-SS-50 Student Sessions
Contribution of LAT1 to amino acid uptake in cancer cells and suppressionof cellular protein synthesis by LAT1 inhibitor
Kou Nishikubo1, Ryuichi Ohgaki1,2, Hiroki Okanishi1, Suguru Okuda1,3, Minhui Xu1,
Hitoshi Endou4, Yoshikatsu Kanai1,21

Dept. Bio-system Pharmacol., Grad. Sch. Med., Osaka Univ., 2Integ. Front. Res. Med. Sci. Div., OTRI, Osaka
Univ., 3Dept. Food Biotech and Struct Biol., Grad. Sch. Agric Life Sci., Tokyo Univ., 4J-Pharma Co., Ltd.

Copyright © The Japanese Pharmacological Society1-SS-51 Student Sessions
Protein phosphatase 6 promotes neurite outgrowth by dephosphorylating
SIN1
Nao Kitamura1, Nobuyuki Fujiwara2, Koji Hayakawa3, Takashi Ohama1, Koichi Sato1
1

Lab. Vet. Pharmacol., Joint Fac. Vet. Med., Yamaguchi Univ.,2Lab. Drug Discovery and Pharmacol., Fac. Vet.
Med., Okayama Univ. Sci, 3Dept. Toxi., Fac. Vet. Med., Okayama Univ. Sci.

Copyright © The Japanese Pharmacological Society1-SS-52 Student Sessions
Polysulfides do not mimic the sulfide-induced acceleration of Cav3.2 T-type2+
Ca channel activity: possible involvement of distinct affinity to zinc
Yoshihito Kasanami1, Yuki Nango1, Hiroshi Masuda1, Fumiko Sekiguchi1, Tsuyako Ohkubo2,
Shigeru Yoshida3, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Kindai Univ., 2Div. Basic Med. Sci. Fundam. Nurs., Fac. Nurs., Fukuoka Nurs.
Coll., 3Dept. Life Sci., Fac. Sci. Engineer., Kindai Univ.

Copyright © The Japanese Pharmacological Society1-SS-53 Student Sessions
Cryo-EM structure of histamine H1 receptor-Gi protein complex
Matsuzaki Yuma, Kazuhiro Kobayashi, Yoshiaki Kise, Hiroyuki Okamoto, Tsukasa Kusakizako,
Osamu Nureki
Univ. of Tokyo, Dept. Science

Copyright © The Japanese Pharmacological Society1-SS-54 Student Sessions
Cryo-EM structure of the human MT1–Gi signaling complex
Okamoto Hiroyuki1, Hirotake Miyauchi1, Asuka Inoue2, Hirokazu Tsujimoto3,
Tsukasa Kusakizako1, Wataru Shihoya1, Keitaro Yamashita1,4, Ryoji Suno5, Norimichi Nomura3,
Takuya Kobayashi5, So Iwata3, Tomohiro Nishizawa6, Osamu Nureki1
1

Uiv. Tokyo, Dept. Science, 2Uiv. Tohoku, Dept. Pharmaceut., 3Uiv. Kyoto, Dept. Med., 4MRC Laboratory of
Molecular Biology, 5Uiv. Kansai Med., Dept. Med., 6Uiv. Yokohama city, Dept. Science

Copyright © The Japanese Pharmacological Society1-SS-55 Student Sessions
The protein level of tumor-promoting factor SET is regulated of cell density
Naoki Kohyanagi1, Nao Kitamura1, Keiko Tanaka1, Nobuyuki Fujiwara2, Takashi Ohama1,
Koichi Sato1
1

Lab. Vet. Pharmacol., Joint Fac. Vet. Med.,Yamaguchi Univ.,2Lab. Drug Discovery and Pharmacol., Fac. Vet.
Med., Okayama Univ. Sci.

Copyright © The Japanese Pharmacological Society1-SS-56 Student Sessions
Allosteric regulation of PI3K by methyl vinyl ketone
Atsushi Morimoto, Takashi Uehara
Dept. Med. Pharmacol., Grad. Sch. Med. Dent. & Pharmaceut. Sci., Okayama Univ.

Copyright © The Japanese Pharmacological Society1-SS-57 Student Sessions
Regulation of Gene Expression via Protein Oxidation
Yuta Iijima1, Tohta Mizushima1, Kengo Nakahara1, Nobumasa Takasugi1, Yosuke Matsushita2,
Toyomasa Katagiri2, Takashi Uehara1
1

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2Division of Genome
Medicine, Institute of Advanced Medical Sciences, Tokushima University

Copyright © The Japanese Pharmacological Society1-SS-58 Student Sessions
Differentiation-inducing factor 1 induces mitochondrial fission via Cofilin
activation in endothelial cells
Inoue Takeru, Ruze Han, Koichi Miura, Toshiyuki Sasaguri
Dept. of Clin. Pharmacol., Kyushu Univ.

Copyright © The Japanese Pharmacological Society1-SS-59 Student Sessions
The effect of intratracheal administration of thyroid hormone (T3) in chronic
obstructive pulmonary disease (COPD) mouse model simulating diseasetype classification.
Noriki Takahashi1,2, Ryunosuke Nakashima1, Aoi Nasu1,2, Megumi Hayashi1, Tomoki Kishimoto1,
Mary Ann Suico1, Hirofumi Kai1, Tsuyoshi Shuto11Dept. Mol. Med. Kumamoto Uinv., 2HIGO Program Kumamoto Univ.

Copyright © The Japanese Pharmacological Society1-SS-60 Student Sessions
Influence of fluoro-loxoprofen on gastrointestinal mucosa
Reiichiro Sasaki1, Yuya Masuda1, Shizuka Jonan1, Naoki Yamakawa2, Tohru Mizushima3,
Kikuko Amagase1
1

Ritsumeikan University, Graduate School of Pharmacy, 2Shujitsu University, School of Pharmacy, 3LTT BioPharma Co., Ltd

Copyright © The Japanese Pharmacological Society1-SS-61 Student Sessions
Alleviative effect of glutamate on 5-fluorouracil-induced intestinal mucositis
in mice
Shizuka Jonan1, Ayana Fujiwara1, Kazumi Iwata2, Shinichi Kato3, Kikuko Amagase1
1

Ritsumeikan University, Graduate School of Pharmacy, 2Kyoto Prefectural University of Medicine, 3Kyoto
Pharmaceutical University

Copyright © The Japanese Pharmacological Society1-SS-62 Student Sessions
Lansoprazole suppresses cisplatin-induced ototoxicity via inhibiting organic
cation transporter 2
Wakai Eri1, Kenji Ikemura2, Masahiro Okuda2, Yuhei Nishimura2
1

Dept. Integrative Pharmacol. Mie Univ. Grad. Sch. Med., 2Dept. Pharm. Osaka Univ. Hosp.

Copyright © The Japanese Pharmacological Society1-SS-63 Student Sessions
Changes in macrophage functions caused by cancer cells
Tagami Yuzuki1, Yuki Aotsu1,2, Hiroyuki Takano1, Ichiro Manabe2
1Dept.Biomol.Cardiovasc.Pharmacol., Pharm., Chiba Univ., 2Dept.Sys.Med., Med., Chiba Univ.

Copyright © The Japanese Pharmacological Society1-SS-64 Student Sessions
Potential therapeutic effects of ozone water on pyoderma and atopic
dermatitis in dogs
Mao Kaneki1, Miyu Takahashi1, Jumpei Uchiyama1,2, Tetsuya Ano3, Tomoki Fukuyama1
1Sch. Vet. Med., Azabu Univ., 2Grad. Sch. Med. Dent. & Pharmaceut. Sci., Okayama Univ., 3Hakuto Co., Ltd.

Copyright © The Japanese Pharmacological Society1-SS-65 Student Sessions
Development of monoclonal antibody-based enzyme immunoassay for
tetranor-Prostaglandin D Metabolite
Masuko Sakura1, Nanae Nagata1, Rikako Inoue1, Tatsuro Nakamura1, Kosuke Aritake2,
Takahisa Murata1
1

Dept. Anim. Radiology. Univ. of Tokyo.,2Lab. Chem. Pharmacol. Daiichi Univ. of Pharm.

Copyright © The Japanese Pharmacological Society1-SS-66 Student Sessions
The Effect of Combined Bcr-Abl Inhibitor and ALDH Inhibitor on Chronic
Myelogenous Leukemia
Kuniki Yurika1, Kenta Yagi2, Rina Yoshida3, Naoki Okamoto1,4, Rie Ando1,4, Yusuke Yamakawa4,
Hirofumi Hamano2, Takahiro Niimura4, Fuka Aizawa4, Yuki Izawa-Ishizawa5, Mitsuhiro Goda1,4,
Yoshito Zamami1,6, Keisuke Ishizawa1,41

Dept. Clin. Pharmacol. & Therap., Tokushima Univ., 2Clin. Res. Ctr. Dev. Therap., Tokushima Univ. Hosp.,3Dept.
Clin. Pharmacol. & Therap., Tokushima Univ., 4Pharm., Tokushima Univ. Hosp., 5Dept. Pharmacol., Tokushima
Univ., 6Pharm., Okayama Univ. Hosp.

Copyright © The Japanese Pharmacological Society