3-P1-01 Poster Sessions
Human mesenchymal stem cells from adipose tissue and umbilical cord
improved neuropathic pain by regulating inflammation and recovery of thedemyelination of sciatic nerve in rats
Kanako Miyano1,2, Minori Ikehata3, Kaori Ohshima2,4, Yuki Yoshida5, Yasuhiro Nose3, Seiichi Yoshihara3, Katsuyuki Oki3, Seiji Shiraishi6, Miaki Uzu7, Miki Nonaka2, Yoshikazu Higami5,
Minoru Narita1,8, Yasuhito Uezono2
1

Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., 2Dept. Pain & Cont. Res., The Jikei Univ. Sch. of Med., 3R&D
Dept. Biomimetics Sympathies Inc., 4Pathol., Immunol. and Microbiol., Grad. Sch. of Med., The Univ. of Tokyo.,
5
Lab. Mol. Pathol. and Metab. Disease, Faculty of Pharm. Sci., Tokyo Univ. of Sci., 6Div. Cancer Pathophysiol.,
Natl. Hosp. Org. Kure Med., 7Vitrigel Prj., Inst. of Agrobiol. Sci., NARO., 8Dept. Pharmacol., Hoshi Univ. Sch. of
Pharm. and Pharma. Sci.

Copyright © The Japanese Pharmacological Society

3-P1-02

Poster Sessions+

KCNQ (Kv7) K channel opener retigabine inhibits pain and itch.
Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe
Lab. of Pharmacol., Sch. of Pharmacy, Kitasato Univ.

Copyright © The Japanese Pharmacological Society

3-P1-03 Poster Sessions
Mechanisms of hyperalgesia in dry eye model rats: involvement of the glial
2+
cells and the voltage-gated Ca channel α2δ subunit in the trigeminal
nucleus
1,2

1

1

1

1

2

Yuto Tei , Yoshinori Mikami , Masanori Ito , Taichiro Tomida , Daisuke Ohshima , Yuichi Hori ,1
Satomi Adachi-Akahane
1Department of Physiology, Faculty of Medicine, Toho University, 2Department of Ophthalmology, Faculty of
Medicine, Toho University

Copyright © The Japanese Pharmacological Society

3-P1-04 Poster Sessions
TRPV1 and TRPA1 are cooperatively involved in the tooth movement-related
pain.
Kazunori Adachi1, Misato Yugawa2
1

Div. Pharmacol. Meikai Univ. Schol. Dent., 2Div. Orthodont. Meikai Univ. Schol. Dent.

Copyright © The Japanese Pharmacological Society

3-P1-05 Poster Sessions
Implicated in spinal cholecystokinin-8 and hemokinin-1 in type 1 diabetes
allodynia in mice
Takafumi Hayashi1, Chizuko Watanabe2, Syu-ichi Kanno3, Masaru Yoshizumi2,
Yasuyuki Agatsuma1, Akiyoshi Hara3, Shinobu Sakurada4
1

Lab. Pharmaceut. Sci., Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ., 2Dept. Physiol. Anato., Fac.
Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ., 3Dept. Clin. Pharmacotherap., Fac. Pharmaceut. Sci., Tohoku
Med. Pharmaceut. Univ., 4Tohoku Med. Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society

3-P1-06 Poster Sessions
Two-way association between sleep disturbance and persistent pain
Yabe Shuhei1, Yusuke Hamada1,2, Kenichi Tanaka1, Yoshiyuki Yamabe1, Michiko Narita2,3,
Naoko Kuzumaki1, Minoru Narita1,21

Dept. Pharmacol., Hoshi Univ., Tokyo, Japan, 2Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan,
Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan3

Copyright © The Japanese Pharmacological Society

3-P1-07 Poster Sessions
Comparison of the effects of Goreisan and loxoprofen on cerebral bloodflow dynamics in meteoropathy model mice
Sumika Ryu1, Yuki Kurauchi1,2, Risako Tanaka1, Makito Haruta3, Kiyotaka Sasagawa3,
Takahiro Seki1,2, Jun Ohta3, Hiroshi Katsuki1,21Dept Chemico-Pharmacol Sci, Sch Pharm, Kumamoto Univ, 2Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci,
Kumamoto Univ, 3Division of Materials Science, Graduate School of Science and Technology, Nara Institute of
Science and Technology

Copyright © The Japanese Pharmacological Society

3-P1-08 Poster Sessions
Itch and pain caused by intradermal injection of sulfides in mouse cheek:
Effect of genetic deletion of Cav3.2 T-type calcium channels
1

1

1

1,2

1

Shotaro Kurahashi , Iyo Nishiyama , Rina Minamino , Hiroyuki Nishikawa , Fumiko Sekiguchi ,11Maho Tsubota , Atsufumi Kawabata
1

Laboratory of Pharmacology & Pathophysiology, Faculty of Pharmacy, Kindai University, 2Fuso PharmaceuticalIndustries, Ltd.

Copyright © The Japanese Pharmacological Society

3-P1-09 Poster Sessions
Phenotypic examination of the endocannabinoid-degrading enzyme
alpha/beta-hydrolase domain containing 6 (ABHD6) knockout rat
Katsuhiko Noguchi1, Kimio Sugaya1, Saori Nishijima1, Mayuko Sakanashi2, Katsumi Kadekawa1,
Shiho Okitsu3, Sayomi Nakamine3, Hidetsugu Torihara3, Hideyuki Yamamoto3
1

Southern Knights’ Laboratory Co., Ltd., 2Dept. Pharmacy, Col. Pharmacy, Kinjo Gakuin University, 3Dept.
Biochemistry, Grad. Sch. Med., Univ. the Ryukyus

Copyright © The Japanese Pharmacological Society

3-P1-10 Poster Sessions
MicroRNA expression profiling in ethanol dependence in mice
Keisuke Mizuo, Tomoka Yamaguchi, Satoshi Watanabe
Dept. of Legal Med. Sapporo Med. Univ. Sch. of Med.

Copyright © The Japanese Pharmacological Society

3-P1-11 Poster Sessions
Inhibitory effect of SB216763, a selective glycogen synthase kinase-3
inhibitor, on morphine-induced Straub’s tail reaction in mice
Junichi Kitanaka1, Nobue Kitanaka1, Utau Horie1, Yumi Kawasaki1, Takashi Sakamoto1,
Junya Yashiro1, Koh-ichi Tanaka2, Kento Igarashi2,3, Kazuo Tomita2,3, Ami Shiomoto4,
Kaname Watabe4, Kiyoshi Nakano4, Hitoshi Takahashi4, Nobuyoshi Nishiyama2, Tomoaki Sato3,
Motohiko Takemura1
1Dept. Pharmacol., Hyogo Col. Med., 2Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci.,
Dept. Applied Pharmacol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 4Muromachi Kikai, Co., Ltd.

3

Copyright © The Japanese Pharmacological Society

3-P1-12 Poster Sessions
Analysis of the tendency of dependence for various targets based on thepsychological characteristic in undergraduate students
Ken-ichi Tanaka, Michiko Konno
Sch. Health Social Services, Saitama Pref. Univ.

Copyright © The Japanese Pharmacological Society

3-P1-13 Poster Sessions
Chronic pain-induced neuronal plasticity in the extended amygdala causes
maladaptive anxiety
Naoki Yamauchi, Hiroshi Nomura, Taiju Amano, Masabumi Minami
Dept Pharmacol Grad Sch Pharm Sci, Hokkaido Univ

Copyright © The Japanese Pharmacological Society

3-P1-14 Poster Sessions
Histological analyses of CRF mRNA expression in the dorsolateral bed
nucleus of the stria terminalis of chronic pain model rats
Saya Arakaki, Daiki Takahashi, Yuta Asaoka, Keisuke Kimura, Ryuto Hara, Keisuke Sakasai,
Hiroe Suzuki, Naoki Yamauchi, Hiroshi Nomura, Taiju Amano, Masabumi Minami
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University.

Copyright © The Japanese Pharmacological Society

3-P1-15 Poster Sessions
Development of a novel stress model using a video-recorded scene of thesocial defeat stress in mice
Yuko Nakatake1,2, Hiroki Furuie2, Masatoshi Ukezono3, Misa Yamada2, Kazumi Yoshizawa1,
Mitsuhiko Yamada2
1

Lab. Pharmacol. Therap., Grad. Sch. Pharmaceut. Sci., Tokyo Univ. Sci., 2Dept. Neuropsychopharmacol., Natl.
Inst. Mental Health, Natl. Center Neurol. Psychiat., 3RIKEN

Copyright © The Japanese Pharmacological Society

3-P1-17 Poster Sessions
Social stress induces subcellular degeneration preceding dendritic loss of
prefrontal pyramidal neurons in mice
Chisato Numa1, Hirotaka Nagai1, Midori Nagai1, Nobuhiko Ohno2, Yuko Mimori-Kiyosue3,
Yosky Kataoka4, Tomoyuki Furuyashiki1
1

Dept. Med. Div. Pharmacol., 2Jichi Med. Univ. Div. Hist. & Cell Biol. Dept. Anat., 3RIKEN BDR Lab. Mol. & Cell.
Dyn., 4RIKEN BDR Lab. Cell. Funct. Img.

Copyright © The Japanese Pharmacological Society

3-P1-18 Poster Sessions
Left-right asymmetry in chronic stress-induced neuroinflammation
Kazutoshi Matsushita, Masayuki Taniguchi, Tomoyuki Furuyashiki
Div. Pharmacol., Grad. Sch. Med., Kobe Univ.

Copyright © The Japanese Pharmacological Society

3-P1-19 Poster Sessions
Role of Microsomal prostaglandin E synthase-1 in acute stress
Kawabata Yuta1, Asumi Doumae1, Hiromi Hirata1, Aki Sakahara1, Satoshi Uematsu2,
Shizuo Akira3, Tatsuo Takahashi1, Yuri Ikeda-Matsuo1
1

Lab. Pharmacol., Dept. Clin. Pharmacy, Fac. Pharmac. Sci., Hokuriku Univ., 2Dept. Immunol. Genomics, Osaka
City Univ. Grad. Sch. Med., 3Lab. Host Defense, WPI Immunol. Front. Res. Ctr, Osaka Univ.

Copyright © The Japanese Pharmacological Society

3-P1-20 Poster Sessions
Loss of function in mouse GAD67 leads to emotional impairments
Shigeo Miyata1, Toshikazu Kakizaki1, Kazuyuki Fujihara1, Hideru Obinata2, Touko Hirano2,
Junichi Nakai3, Mika Tanaka4, Shigeyoshi Itohara4, Kenji Tanaka5, Masahiko Watanabe6,
Manabu Abe7, Kenji Sakimura7, Yuchio Yanagawa1
1

Dept. Gen. Behav. Neurosci., Grad. Sch. Med., Gunma Univ., 2Lab. Anal. Instr., Grad. Sch. Med., Gunma Univ.,Div. Oral Physiol., Dept. Oral Funct. Mor., Grad. Sch. Dent., Tohoku Univ.,4Lab. Behav. Gen., RIKEN Brain Sci.
Inst., 5Dept. Neuropsychiat., Sch. Med., Keio Univ., 6Dept. Anat., Fac. Med., Hokkaido Univ., 7Dept. Anim. Mod.
Devel., Brain Res. Inst., Niigata Univ.
3

Copyright © The Japanese Pharmacological Society

3-P1-21 Poster Sessions
Glutamatergic neurons from medial prefrontal cortex to dorsal raphe
nucleus regulates maternal aggression in mice
Yoshikage Muroi, Toshiaki Ishi
Dep. Vet. Med., Obihiro Univ.

Copyright © The Japanese Pharmacological Society

3-P1-22 Poster Sessions
The amygdalohippocampal area that projects to the medial preoptic area
mediates aggression toward the infantKeiichiro Sato, Yumi Hamasaki, Kiyoshiro Fukui, Masabumi Minami, Taiju Amano
Dept. of Pharmacol, Grad. Sch. of Pharmaceut. Sci. Hokkaido Univ.

Copyright © The Japanese Pharmacological Society

3-P1-23 Poster Sessions
Synaptic inputs derived from the central nucleus of amygdala thatsuppresses neurons in the rhomboid nucleus of the bed nucleus of the stria
terminals of paternal miceShunsaku Murakawa, Haruka Uki, Masabumi Minami, Taiju Amano
Dept. of Pharmacology, Grad. Sch. of Pharmaceutical Science, Hokkaido Univ, Hokkaido, Japan

Copyright © The Japanese Pharmacological Society

3-P1-24 Poster Sessions
Long-term administration of D2 receptor blocker sulpiride changes social
behavioral pattern in male miceHamasaki Yumi, Masabumi Minami, Taiju Amano
Dept. of Pharmacology, Grad. Sch. of Pharmaceutical Sciences, Hokkaido Univ, Hokkaido, Japan

Copyright © The Japanese Pharmacological Society

3-P1-25 Poster Sessions
Blonanserin and 1-(2-Pyriidinyl)-piperazine suppress impulsive action in rats
Hitomi Sasamori1, Naoya Nishitani2, Yu Ohmura1, Mitsuhiro Yoshioka1
1

Dept. Neuropharmacol. Hokkaido Univ., 2Lab. Mol. Pharmacol. Kanazawa Univ.

Copyright © The Japanese Pharmacological Society

3-P1-26 Poster Sessions
Serotonergic activity in the dorsal raphe nucleus is required for modelbased decision making
Yu Ohmura1, Kentaro Iwami2, Hitomi Sasamori1, Chiaki Sugiura1, Youcef Bouchekioua1,
Mitsuhiro Yoshioka1
1

Dept Neuropharmacol, Hokkaido Univ, Hokkaido, Japan, 2Hokkaido Univ Sch Med, Hokkaido, Japan

Copyright © The Japanese Pharmacological Society

3-P1-27 Poster Sessions
Behavioral Characterization of Dopamine D5 Receptor Knockout(D5KO) Mice
Chiaki Sugiura
Dept. Neuropharmacol. Hokkaido Univ.

Copyright © The Japanese Pharmacological Society

3-P1-28 Poster Sessions
Ameliorating effects of guanfacine, an adrenergic α2A receptor agonist, on
AD/HD-like behaviors in an AD/HD model rat, male adolescent SHRSP/Ezo
Taku Yamaguchi, Ryosuke Shinozaki, Tatsuya Oka
Dept. Pharmacother. and Neuropsychopharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.

Copyright © The Japanese Pharmacological Society

3-P1-29 Poster Sessions
Inhibitory effects of local anesthetics on muscarinic receptors: effects on
2+
the Ca release from intracellular store and recruitment of beta-arrestin.
Shimatani Mari1, Akihiro Nezu2, Akihiko Taimura2
1

Div. Reconstructive Surg Oral Maxillofac Reg., Health Sci. Univ. Hokkaido, Sch. of Dent., 2Div. Pharmacol.,Health Sci. Univ. Hokkaido, Sch. of Dent.

Copyright © The Japanese Pharmacological Society

3-P1-30 Poster Sessions
Annexin A2 is involved in activation of AKT upon endothelin-1 stimulation inmelanoma cells
Yuichi Mazaki, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa
Dept. Cell. Pharm., Grad. Sch. Med., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society

3-P1-31 Poster Sessions
Localization analysis of several NCKX2-NCLX chimeras into plasma
membrane/mitochondrial inner membrane
Takayuki Nemoto1, Tomo Kita1, Hideaki Tagashira1, Satomi Kita1,2, Takahiro Iwamoto1
1

Dept. Pharmacol., Fac. Med., Fukuoka Univ., 2Dept. Pharmacol., Fac. Pharma. Sci., Tokushima Bunri Univ.

Copyright © The Japanese Pharmacological Society

3-P1-32 Poster Sessions
Distribution of mammal-like melanin concentrating hormone type 1 and 2
receptor expressing neurons in the brain of a basal actinopterygian fish,
Polypterus senegalus
Morio Azuma, Taka-aki Koshimizu
Div. of Mol. Pharmacol., Dept. of Pharmacol., Jichi Med. Univ.

Copyright © The Japanese Pharmacological Society

3-P1-33 Poster Sessions
Receptor functional analysis of leptin resistance by adenosine- BRET
analysis
Toru Hosoi1, Takenori Matsuura3, Anisia Silva4, Momoe Wada3, Syu Matsuzaki3,
Michitaka Sugiyama2, Naoshi Kodama2, Ralf Jockers4, Julie Dam4, Koichiro Ozawa2
1

Dept. Clin. Pharmacology, Facul. Pharmaceutical Sci., Sanyo-Onoda City Univ., 2Dept. Pharmacotherapy, Grad.
Sch. Biomed. Health Sci., Hiroshima Univ., 3Dept. Pharmacotherapy, Sch. Pharm. Hiroshima Univ., 4Inserm U1016,
Institut Cochin, Dept Endocrinology, Metabolism and Diabetes, Paris, France

Copyright © The Japanese Pharmacological Society

3-P1-34 Poster Sessions
Collapsin response mediator protein 2 was one of targets for 15-deoxy 12,14
Δ -prostaglandin J2
Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma
Dept. Pharmaceutic. Health, Himeji Dokkyo Univ.

Copyright © The Japanese Pharmacological Society

3-P1-35 Poster Sessions
Differentiation-inducing factor 1 activates AMP-regulated kinase/Cofilin
pathway to regulate the actin cytoskeleton.
Koichi Miura, Takeru Inoue, Ruzhe Han, Toshiyuki Sasaguri
Kyushu Univ., Fac. of Med. Sci.

Copyright © The Japanese Pharmacological Society

3-P1-36 Poster Sessions
Development of Histamine N-methyltransferase Inhibitors for Brain
DisordersTakeo Yoshikawa, Rina Otsuka, Yuki Sato, Kazuhiko Yanai
Dept Pharmacol Tohoku Univ Grad Sch Med

Copyright © The Japanese Pharmacological Society

3-P1-37 Poster Sessions
The development of miR-96-5p gene knock out technique by CRISPR/Cas9
systemNobuko Matsumura1, Chisato Kinoshita1, Toshio Nakaki2, Koji Aoyama1
1

Dept. Pharmacol., Teikyo Univ. Sch. Med., 2Fac. Pharma-Sci., Teikyo Univ.

Copyright © The Japanese Pharmacological Society

3-P1-38 Poster Sessions
Evaluation of seizure sensitivity and potential excitation foci in Phf24-KO
rats
Naofumi Kunisawa1, Hiroaki Hisadumi1, Masaki Kato1, Saki Shimizu1, Kazuaki Sato2,
Masato Kinboshi1, Masao Matsuhashi3, Akio Ikeda3, Tadao Serikawa1, Yukihiro Ohno1
1

Dept. Pharmacol., Osaka Univ. Pharmaceut. Sci., 2Dept. neurol., Ijinkai takeda general Hosp., 3Dept. Epilepsy,
Mov. Dis. and Physiol., Kyoto Univ.

Copyright © The Japanese Pharmacological Society

3-P1-39 Poster Sessions
Lifelong measurement of locomotor activity and body temperature in grouphoused laboratory mice by wireless power transmission
Kazuhiko Yanai1, Takeo Yoshikawa1, Kenichi Sagara2, Shu Sasaki2
1

Tohoku Univ. Sch. Med. Dept. Pharmacol., 2HIKARIDENSHI, CO., LTD

Copyright © The Japanese Pharmacological Society

3-P1-40 Poster Sessions
Our preclinical support of neurological research approaches using
cerebrospinal fluid
Kohei Araki, Keita Saito, Kotaro Suzuki, Toru Nonomura, Noriyuki Yamazaki
New Drug Research Center, Inc.

Copyright © The Japanese Pharmacological Society

3-P1-41 Poster Sessions
Efforts for promotion of Use of Radioisotopes (RI) -RI Experimental
Protocols for BeginnersRikako Azuma1, Hiroyuki Tsunokuni1, Keiichi Matsunami2, Masayuki Hara3, Shinsuke Katoh4,
Hiroyuki Iizuka5
1

Japan Radioisotope Association, 2Grad. Sch. of Medicine, Juntendo Univ., 3Res. Core, Inst. of Res., Tokyo Medical
and Dental Univ., 4Dept. of Health Pharm., Yokohama Univ. of Pharm., 5Sch. of Eng. Environ. Health and Safety
Office., Univ. of Tokyo

Copyright © The Japanese Pharmacological Society

3-P1-42 Poster Sessions
Structure prediction of the N-terminal regulatory domain of the humantryptophan hydroxylase 2
Masanori Ootaki1, Tomoko Hiroi2, Yuki Ohta1, Yuko Takeba1, Keisuke Kida1, Hiroaki Matsui2,
Naoki Matsumoto1
1

St. Marianna Univ. Sch. Med. Dept. Pharmacol., 2Inst. Radioisotope Res. St. Marianna Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society

3-P1-43 Poster Sessions
Comparison of medication self-management for older adults supported bynurses at general hospitals and home-visit nursing stations
Kanako Sakane1, Yuta Kobayashi1, Mayumi Miyamoto1, Miki Fukuma1, Yuko Tsumoto1,
Hiromi Uchida2
1

Shimane Uni., Fac. Med., Dept. Nursing, 2Tenri Helth Care Uni.

Copyright © The Japanese Pharmacological Society

3-P1-44 Poster Sessions
Integrated safety evaluation of benzodiazepines using human iPS cell
technology
Tsunemoto Kazunobu1, Shigeru Yamada1,2, Yasunari Kanda1
1Div. Pharmacol, NIHS, 2PEIJ

Copyright © The Japanese Pharmacological Society

3-P1-45 Poster Sessions
Antioxidative activity of fructose 1,6-bisphosphate as a direct free radical
scavenger
Kazue Ogata1, Kahona Ono2, Osamu Tokumaru1
1

Department of Physiology, Facalty of Welfare and Health Sciences, Oita University,2Medical student, School of
Medicine, Oita University Faculty of Medicine

Copyright © The Japanese Pharmacological Society

3-P2-01

Poster Sessions

ATX- increases intracellular Na+ and Ca2+ concentration in pulmonary vein+
2+
cardiomyocytes by activating reverse-mode Na /Ca exchanger
Taro Saito, Aiko Ohba, Yuta Takano, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.

Copyright © The Japanese Pharmacological Society

3-P2-02 Poster Sessions
Elucidation of mechanisms that trigger torsades de pointes in drug-induced
long QT syndrome: a simulation study
Kunichika Tsumoto1, Takao Shimamoto2, Akira Amano2, Yuhichi Kuda1, Mamoru Tanida1,
Yasutaka Kurata1
1

Dept. Physiol, Kanazawa Med. Univ., 2Dept. Bioinfo, Ritumeikan Univ.

Copyright © The Japanese Pharmacological Society

3-P2-03 Poster Sessions
Different modulatory effects of isoflurane and halothane onarrhythmogenesis elicited by dofetilide in rabbits.
Satoshi Kawakami, Yoshinobu Nagasawa, Megumi Aimoto, Akira Takahara
Dept. Pharmacol. Therap., Fac. Pharmaceut. Sci. Toho Univ.

Copyright © The Japanese Pharmacological Society

3-P2-04 Poster Sessions
Dulaglutide inhibited perilipin 2-induced atrial fibrillation through the
improvement of atrial impulse conduction slowing in transgenic mice
Nanae Ishida1, Shogo Yukawa1, Satsuki Sato2, Jinya Suzuki2, Eiichi Taira3, Masamichi Hirose1
1

Dept. Pathophysiol. and Pharmacol., Iwate Medical Univ., 2Third Dept. Internal Med., Univ. of Fukui, 3Dept. of
Pharmacol., Iwate Medical Univ.

Copyright © The Japanese Pharmacological Society

3-P2-05 Poster Sessions
Manifestation of proarrhythmic properties of IKACh blocker tertiapin in the rat
dilated atria caused by chronic volume overload
Megumi Aimoto, Ryohei Suzuki, Yuka Taneichi, Yoshinobu Nagasawa, Akira Takahara
Dept. Pharmacol. Ther., Fdt. Pharmaceut. Sci. Toho Univ.

Copyright © The Japanese Pharmacological Society

3-P2-06 Poster Sessions
Comprehensive and rigorous analysis of drug-induced QT interval
prolongation in anesthetized guinea pigs using 11 antihistamines withclinical reports on adverse drug reactions
Yoshinobu Nagasawa1, Miki Shimizu1, Misa Oshiba1, Go Minemoto1, Yuichi Kenmotsu1,
Kengo Kimura1, Kensuke Omura1, Naoki Omuro1, Kaori Fujiwara1, Haruka Matsuzaki1,
Kazuko Kobayashi1,2, Satoshi Kawakami1, Megumi Aimoto1, Akira Takahara1
1Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci. Toho Univ.,2Dept. Pharm. Toho Univ. Ohashi Med. Ctr.

Copyright © The Japanese Pharmacological Society

3-P2-07 Poster Sessions
Characteristics of sudden death in cardiac-specific conditional NCX1
knockout mice
Hideaki Tagashira1, Satomi Kita1,2, Takahiro Iwamoto1
1

Dept. Pharmacol., Fac. of Med., Fukuoka Univ., 2Dept. Pharmacol., Fac. of Pharma. Sci., Tokushima Bunri Univ.

Copyright © The Japanese Pharmacological Society

3-P2-08 Poster Sessions
Hsp90 contributes to cardiac hypertrophy in the development of heart failure
via regulating c-Raf.
Takumi Itoh, Tetsuro Marunouchi, Emi Yano, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

Copyright © The Japanese Pharmacological Society

3-P2-09

Poster Sessions
2+

Pathophysiological role of Ca permeable TRPV2 channel in myocardialischemia reperfusion injury
Yuko Iwata1, Shigeo Wakabayashi2, James Pearson1
1

NCVC, Cardiac Physiology, 2Osaka Aoyama Univ., Health Science

Copyright © The Japanese Pharmacological Society

3-P2-10 Poster Sessions
Gender differences in the effect of spontaneous exercise on heart failure in
DCM model mice
Masami Sugihara1, Ryo Kakigi2, Takashi Murayama3, Takashi Miida1, Takashi Sakurai3,
Sachio Morimoto4, Nagomi Kurebayashi31Dept.Clin.Lab.and Med.,Juntendo Univ., 2Fac. Mgmt. & Info. Sci., Josai Int. Univ., 3Dept.Phamacol.,Juntendo
Univ., 4Dept. Health Sci. at Fukuoka, IUHW

Copyright © The Japanese Pharmacological Society

3-P2-11 Poster Sessions
Development of drugs for anticancer drug-induced cardiotoxicity using acyl
ghrelin and des-acyl ghrelin extracted from the stomach of salmon and tuna
Toshiki Kawashima1,2, Miki Nonaka2, Minoru Kihara3, Hidekazu Katayama4, Kaori Ohshima2,5,
Kanako Miyano6, Kazumi Yoshizawa1, Yasuhito Uezono2,7
1

Lab. of Pharmacol. and Ther., Dept. of Pharm., Fac. of Pharmaceut. Sci., Tokyo Univ. of Sci., Chiba, Japan,2Dept.
of Pain Control Res., The Jikei Univ. Sch. of Med., Tokyo, Japan, 3Dep. of Mar. Biol. and Sci., Sch. of Biol. Sci.,
Tokai Univ., Hokkaido, Japan, 4Dep. of Appl. Biochem., Sch. of Eng., Tokai Univ., Kanagawa, Japan, 5Patho.,Immunol. & Microbiol., Grad. Sch. of Med., Univ. of Tokyo, Tokyo, Japan,6Div. of Cancer Pathol., Natl. Cancer
Ctr. Res. Inst., Tokyo, Japan, 7Div. of Support. Care Res., Explor. Oncol. Res. & Clin. Trial Ctr., Natl. Cancer Ctr.
Res. Inst., Tokyo, Japan

Copyright © The Japanese Pharmacological Society

3-P2-12 Poster Sessions
Arresten, a cleaved fragment of type IV collagen α1 chain, regulates
functions of cardiac fibroblasts and left atria
Akira Sugiyama, Shiho Tajima, Riki Yamamoto, Kosuke Otani, Muneyoshi Okada,
Hideyuki Yamawaki
Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society

3-P2-13 Poster Sessions
Chronic toxicity assessment of nilotinib using human-induced pluripotent
stem cell-derived cardiomyocytes
Hayashi Sayo, Ayano Satsuka, Shota Yanagida, Yasunari Kanda
Div. Pharmacol, NIHS

Copyright © The Japanese Pharmacological Society

3-P2-14 Poster Sessions
Assessment of drug-induced contractility in iPS-CMs by cell motion imaging
and cell-induced electrical impedance monitoring.
Satsuka Ayano, Sayo Hayashi, Yasunari Kanda
Div. Pharmacol, NIHS

Copyright © The Japanese Pharmacological Society

3-P2-15 Poster Sessions
Tanshinone VI promotes the differentiation of cardiosphere-derived cells
into cardiomyocytes.
Tetsuro Marunouchi, Minami Ikoshi, Emi Yano, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

Copyright © The Japanese Pharmacological Society

3-P2-16 Poster Sessions
The effect of chemical sympathetic dennervation on the postnatal heartdevelopment.
Takuro Numaga-Tomita1, Hiroyuki Kawagishi1, Tsutomu Nakada2, Mitsuhiko Yamada1
1

Dept Mol Pharamcol, Sch Med, Shinshu Univ, 2Res Center Supp Adv Sci, Shinshu Univ

Copyright © The Japanese Pharmacological Society

3-P2-17 Poster Sessions
A novel intracellular drug-delivery system specific for cardiomyocytes using
RNA aptamer
Takeshi Honda1, Hiroki Sakai1, Makoto Inui1,21

Dept. Pharmacol. Grad. Sch. Med., 2YIC Rehab. Col.

Copyright © The Japanese Pharmacological Society

3-P2-18 Poster Sessions
Analysis of the molecular mechanism of compensatory hypertrophy2+
associated enhancement of salivary secretion using the intravital Ca
imaging and gene analysis.
1

2

3

1

Akihiro Nezu , Shigeru Takahashi , Takao Morita , Akihiko Tanimura
1

Div. Pharmacol, Health Sci. Univ. Hokkaido Sch. Dent., 2Dept. Oral Functional. Anat., Hokkaido Univ. Grad. Sch.
Dent. Med., 3Dept. Biochem., Nippon Dent. Univ. at Niigata

Copyright © The Japanese Pharmacological Society

3-P2-19 Poster Sessions
Cdc42-deficiency induces salivary hyposecretion and maintains lacrimal
secretion in mice.
Nagase Haruna, Akiko Shitara, Yuta Ohno, Masanori Kashimata
Asahi Univ., Dent., Pharmacol.

Copyright © The Japanese Pharmacological Society

3-P2-20 Poster Sessions
Regulation by purinergic signal of glucose-induced insulin secretion fromiGL insulinoma cells.
Masa-aki Ito, Chinatsu Machida, Kazuki Yoshida, Isao Matsuoka
Lab. Pharmacol., Fac. Pharm, Takasaki Univ. Health and Welfare

Copyright © The Japanese Pharmacological Society

3-P2-21 Poster Sessions
Effect of sucrose beverage intake on blood glucose level and insulin
secretion
Sato Sachiko, Yukiko Kondo, Eiichi Taira
Dept. of Pharmacol., Iwate Med. Univ., Morioka, Japan

Copyright © The Japanese Pharmacological Society

3-P2-22 Poster Sessions
Thyrotropin receptor antibodies (TRAbs) induced by Epstein-Barr virus
reactivation: Significance on Graves’ disease
Nagata Keiko1, Kazuhiko Hayashi2, Yukio Satoh3, Mitsuhiko Osaki4, Junichiro Miake1,
Yoshinori Ichihara1, Tatsuya Sawano1, Yuhang Zhou1, Agung Priyono1, Kazuhiko Matsuzawa1,
Takeshi Imamura1
1Div. Pharmacol. Fac. Med. Tottori Univ.,2Pathol.Dept. Fac. Med. Tottori Univ., 3Div. Developmental Biol. Sch.
Life Sci. Fac. Med. Tottori UNiv., 4Div. Exp. Pathol Sch. Life Sci. Fac. Med. Tottori Univ.

Copyright © The Japanese Pharmacological Society

3-P2-23 Poster Sessions
Possible roles of autophagy related proteins ATG2A and ATG7 in the
differentiation of human endometrial stromal cells
Saito Yuri1, Junya Kojima2, Atsuya Tsuru1, Mikihiro Yoshie1, Kazuya Kusama1, Kazuhiro Tamura1,
Hirotaka Nishi2
1

Dept. Endocrine Pharmacol.,Tokyo Univ. Pharm. & Life Sci., 2Dept. Obstet. & Gynecol., Tokyo Med. Univ.

Copyright © The Japanese Pharmacological Society

3-P2-24 Poster Sessions
Effect of adipose tissue-derived stem/stromal cells on muscle atrophy
Yuki Ohta1, Tsukasa Kobayashi1, Yuko Takeba1, Masanori Ootaki1, Keisuke Kida1,
Minoru Watanabe2, Taroh Iiri1, Mitsuko Takenaga3, Naoki Matsumoto1
1

Dept. of Pharmacol., St Marianna Univ. Sch. of Med., 2Inst. for Anim. Exp., St. Marianna Univ. Grad. Sch. of Med.,
Inst. of Med. Sci., St Marianna Univ. Sch. of Med.

3

Copyright © The Japanese Pharmacological Society

3-P2-25 Poster Sessions
17β-estradiol attenuates sepsis-induced myopathy in mice
Shunya Takeshita, Chihiro Hibi, Kazuho Sakamoto, Junko Kurokawa
Dept. Bio-Info. Pharmacol., Univ. Shizuoka

Copyright © The Japanese Pharmacological Society

3-P2-26 Poster Sessions
Identification of binding site for a novel RyR1-selective inhibitor
Takashi Murayama1, Nagomi Kurebayashi1, Takuya Kobayashi1, Haruo Ogawa2,
Masami Kodama2, Shuichi Mori3, Hiroyuki Kagechika3, Takashi Sakurai11

Dept. Pharmacol., Juntendo Univ. Sch. Med., 2IQB, Univ. Tokyo, 3IBB, Tokyo Med. Dent. Univ.

Copyright © The Japanese Pharmacological Society

3-P2-27

Poster Sessions
2+

Characterization of novel RyR1 selective inhibitors identified by ER Ca
measurements

Matsukawa Hiroyuki1, Takashi Murayama1, Takuya Kobayashi1, Nagomi Kurebayashi1,
Toshiko Yamazawa2, Mari Ikegami-Yuasa3, Shuichi Mori3, Hiroyuki Kagechika3, Takashi Sakurai11

Dept. Pharmacol., Juntendo Univ. Sch. Med., 2Dept. Mol. Physiol., Jikei Univ. Sch. Med., 3IBB, Tokyo Med. Dent.
Univ.

Copyright © The Japanese Pharmacological Society

3-P2-28 Poster Sessions
Effects of Palmitoleic acids on skeletal muscle differentiation in
hyperglycemic environment.
Yayoi Tokunaga1, Hitomi Yoshizaki2, Akiyo Toriumi2, Chisato Ishida3, Ritsuko Kawaharada4,
Masatoshi Hori1, Akio Nakmura2
1

Lab. of Veterinary Pharmacol., Grad. Sch. of Agr. and Life Sci., Tokyo Univ.,2Department of Food and Health
Sciences, Jissen Women’s University, Hino, Japan,3Department of nutrition, Japanese Haramachi Red Cross
Hospital, Japan, 4Department of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki, Japan

Copyright © The Japanese Pharmacological Society

3-P2-29 Poster Sessions
Evaluation of the usefulness of three-dimensional organoid culture in the
drug screening of non-alcoholic steatohepatitis (NASH) disease
Yamamoto Haru1, Megumi Yamanaka1, Elbadawy Mohamed2, Tatsuya Usui1, Kazuaki Sasaki1
1

Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo
University of Agriculture and Technology, 2Department of Pharmacology, Faculty of Veterinary Medicine, Benha
University

Copyright © The Japanese Pharmacological Society

3-P2-30 Poster Sessions
Disruption of steroidogenic acute regulatory protein-related lipid transfer
domain containing 10 (STARD10) prevents the development of nonalcoholicsteatohepatitis (NASH)
Masanori Ito, Daisuke Ohshima, Yoshinori Mikami, Taichiro Tomida, Satomi Adachi-Akahane
Department of Physiology, Faculty of Medicine, Toho University

Copyright © The Japanese Pharmacological Society

3-P2-31 Poster Sessions
Effects of Bezafibrate on Carbon Tetrachloride and T0901317-Induced
Nonalcoholic Steatohepatitis Model
Yukiko Kawasaki, Shoko Otsu, Yuri Noda, Takahito Imaizumi, Hisami Matsushita, Katsumi Endo,
Yasushi Hirasawa
Nihon Bioresearch Inc.

Copyright © The Japanese Pharmacological Society

3-P2-32 Poster Sessions
Roles of heparan sulfate against CCl4 cytotoxicity in HepG2 cells
Takuro Matsuzawa, Ai Shimane, Kazuhiko Yanai, Takeo Yoshikawa
Dept Pharmacol. Tohoku Univ Grad Sch Med

Copyright © The Japanese Pharmacological Society

3-P2-33 Poster Sessions
Platelets attenuate monocrotaline-induced liver injury
Fumisato Otaka1,2, Yoshiya Ito1,2, Kanako Hosono1,2, Kou Hatanaka1,2, Wasaburo Koizumi3,
Hideki Amano1,2
1

Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, 2Departmentof Pharmacology, Kitasato University School of Medicine, 3Department of Gastroenterology, Kitasato University
School of Medicine

Copyright © The Japanese Pharmacological Society

3-P2-34 Poster Sessions
Expression of the growth-related factors in the liver of fetal rats
Tsukasa Kobayashi1, Yuko Takeba1, Yuki Ohta1, Masanori Ootaki1, Keisuke Kida1,
Minoru Watanabe2, Taroh Iiri1, Naoki Matsumoto1
1

Department of Pharmacology, St Marianna University School of Medicine, 2Institute for Animal Experimentation,
St Marianna University Graduate School of Medicine

Copyright © The Japanese Pharmacological Society

3-P2-35 Poster Sessions
CRAC channel blockers attenuate the activation of human hepatic stellate
cells
Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society

3-P2-36 Poster Sessions
The alternation of adenosine-related genes likely progress HSC activation in
inflammatory condition.
Naoki Dohi1, Momoka Yamaguchi1, Sin-ya Saito1,2, Tomohisa Ishikawa1
1

Dept. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka, 2Fac. Vet. Med., Okayama Univ. Sci.

Copyright © The Japanese Pharmacological Society

3-P2-37 Poster Sessions
The formation of lymphatic vessels and macrophages contribute to liver
repair after liver injury
Shuji Nakamoto1,2,3, Yoshiya Ito1,2, Takuya Goto1,2,3, Kanako Hosono1,2, Ko Hatanaka1,2,
Masataka Majima1,2,4, Hideki Amano1,2
1

Dept. Mol. Pharmacol., Kitasato Univ. Grad. Sch. Med., 2Dept. Pharmacol., Kitasato Univ. Sch. Med., 3Dept.
Surg., Kitasato Univ. Sch. Med., 4Dept. Med. Therap., Kanagawa Inst. Tech.

Copyright © The Japanese Pharmacological Society

3-P2-38 Poster Sessions
In vivo S-allyl-L-cysteine and some analogues accelerates liver regenerationin 70% partially hepatectomized rats.
Kazuki Kurihara1, Hajime Moteki1, Hideshi Natsume2, Masahiko Ogihara1, Mitsutoshi Kimura1
1Dept. Clin. Pharmacol., Fac. Pharma. Sci., Josai Univ., 2Dept. pharmaceutics, Fac. Pharma. Sci., Josai Univ.

Copyright © The Japanese Pharmacological Society

3-P2-39 Poster Sessions
Functional analysis of FSGS-associated TRPC6 channels and its
relationship to early-onset and late-onset of the renal disease
Ryo Okada1, Tatsuya Komaki1,2, Onur K. Polat3,4, Hideyuki Kobayashi1, Takanori Kihara2,
Masayuki X. Mori1
1

Bio-materer. Chem., Sch. Med., UOEH, 2Graduate School of Environmental Engineering, The University of
Kitakyushu, 3Dept. Synth. Chem. Biol. Chem., Grad. Sch. Eng., Kyoto Univ., 4Rush Univ., Chicago, USA

Copyright © The Japanese Pharmacological Society

3-P2-40 Poster Sessions
Inhibition of CRAC channel current by TRPV1 channel agonist andantagonist in RBL cells
Ayumi Nakayama, Minoru WakamoriDiv. Mol. Pharmacol. Cell Biophys., Grad. Sch. Dent., Tohoku Univ.

Copyright © The Japanese Pharmacological Society

3-P2-41 Poster Sessions
Role of TRPM7 channel in pancreatic cancer
Hosokoshi Atsuki1, Nobuaki Takahashi2, Reiko Sakaguchi1, Atsusi Masamune3, Hiroshi Harada4,
Yasuo Mori1
1

Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ, 2The Hakubi Cent., Kyoto Univ, 3Dept.
Gastroente., Grad. Sch. Med., Tohoku Univ, 4Dept. Genome Dynamics., Radiation Biology Cent., Grad. Sch. Bio.,
Kyoto Univ

Copyright © The Japanese Pharmacological Society

3-P2-42 Poster Sessions
TRPC channels selective compounds for novel fibrotic disease treatment
and trafficking of antisense oligonucleotides
Tomorrow Amatani1, Yuuya Kasahara2, Masahito Shimojo3, Motohiro Nishida4,5, Ryu Nagata3,
Satoshi Obika2,3, Yasuo Mori1
1

Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ, 2Natl. Inst. Biomed. Innov. Health. & Nut.
(NIBIOHN), 3Dept. Bioorg. & Chem., Grad. Sch. Pharmaceut. Sci., Osaka Univ, 4Dept. Pharm., Grad. Sch., Kyushu
Univ, 5Nat. Ins. Physiol. Sci. (NIPS), Nat. Ins. Natural Sci. (NINS)

Copyright © The Japanese Pharmacological Society

3-P2-43 Poster Sessions
Regulation of mitochondrial activities by TRPA1 channel
Yoshiaki Hasegawa1, Satoru Hamano1, Yasuo Mori1, Nobuaki Takahashi1,21Lab. Mol. Biol. Grad. Sch. Eng. Kyoto Univ., 2The Hakubi Cent., Kyoto Univ.

Copyright © The Japanese Pharmacological Society

3-P2-44 Poster Sessions
Different Zinc sensitivity of TRPA1 between human and chicken.
Masaki Matsubara, Noriyuki Hatano, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki
Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi Gakuin University

Copyright © The Japanese Pharmacological Society

3-P2-45 Poster Sessions
C-terminal domain regulates the plasma membrane localization of aquaporin-5Shin-ichi Muroi, Yoichiro Isohama
Lab. Appl. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. of Sci.

Copyright © The Japanese Pharmacological Society

3-P2-46 Poster Sessions
Characterization of G-protein coupled receptors selectively localized inprimary cilia in ciliated cellular models
Yuki Kobayashi1, Nobuya Nishimura1, Yuki Tokubaga1, Tatsuo Miyamoto2, Yumiko Saito1
1

Hiroshima Univ. Grad. Sch. Integrate Sci. Life, 2Hiroshima Univ. Res. Inst. Radiobiol.

Copyright © The Japanese Pharmacological Society

3-P2-47 Poster Sessions
A dual prokaryotic (E. coli) expression system (pdMAX)
Manabu Murakami1, Agnieszka Murakami1, Shirou Itagaki2
1

Department of Pharmacology, Hirosaki University Graduate School of Medicine, Hirosaki, 2Collaboration Centerfor Community and Industry, Sapporo Medical University

Copyright © The Japanese Pharmacological Society