3-O-102 Oral Sessions
IL-33 dependent facilitation of glutamatergic neurotransmission in the Vc
causes orofacial neuropathic pain
Yoshinori Hayashi, Yuki Kimura, Masamichi Shinoda
Dept. of Physiol, Nihon Univ. Sch. of Dent.

Copyright © The Japanese Pharmacological Society3-O-103 Oral Sessions
Sex-dependent roles of spinal microglia in pain hypersensitivity in mice.
Norikazu Kiguchi1, Kentaro Suzuki2
1

Dept. Physiol. Sci., Sch. Pharm. Sci., Wakayama Med. Univ., 2Dept. Development. Genet., Inst. Adv. Med.,
Wakayama Med. Univ.

Copyright © The Japanese Pharmacological Society3-O-104 Oral Sessions
Nicotine suppresses central post-stroke pain via facilitation of descending
noradrenergic neuron through activation of orexinergic neuron
Kazuo Nakamoto, Shogo Tokuyama
Dept. Clin. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ.

Copyright © The Japanese Pharmacological Society3-O-105 Oral Sessions
Distinct pain control in the spinal dorsal horn via astrocytic α- and βadrenoceptors
Kohei Yoshihara1, Riku Kawanabe1, Sawako Uchiyama1, Ryoji Shirasaka1, Keisuke Koga2,Makoto Tsuda1
1Dept. Mol. and Syst. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ., 2Dept. Neurophysiol., Hyogo Col.
MedCopyright © The Japanese Pharmacological Society3-O-107 Oral Sessions
Anti-arrhythmic effects of novel RyR2 inhibitors screened from well2+
characterized drug library by ER Ca monitoring.
Masami Kodama1, Mai Takenaka1, Takashi Murayama1, Koichiro Ishii1, Mari Ishigami-Yuasa2,Shuichi Mori2, Masato Konishi1, Sachio Morimoto3, Nobuyuki Murakoshi4, Takashi Sakurai1,Hiroyuki Kagechika2, Nagomi Kurebayashi11Dept. Pharmacol., Fac. Med., Juntendo Univ., 2IBB, Tokyo Med. Dent. Univ., 3Dept. Health Sci. Fukuoka, Int. Univ.
of Health and Welfare, 4Fac. Med., Univ. of Tsukuba

Copyright © The Japanese Pharmacological Society3-O-108 Oral Sessions
Loss-of-function RyR2 mutations cause various types of arrhythmias
2+
through divergent abnormal Ca signaling
Nagomi Kurebayashi1, Takashi Murayama1, Naoyuki Tetsuo1, Sayako Hirose2,3, Minoru Horie4,
Seiko Ohno2, Takashi Sakurai11

Dept Pharmacol, Juntendo Univ Fac Med, 2Dept Cardiovasc Med, Kyoto Univ, 3Dept Biosci Genetics, NCVC,
4
Dept Cardiovasc Med, Shiga Univ Med Sci

Copyright © The Japanese Pharmacological Society3-O-109 Oral Sessions
Possible involvement of pressure-sensitive intrinsic mechanism of aortic
wall to optimize aortic elasticity assessed in anesthetized rabbits
Yoshinobu Nagasawa1, Kiyoshi Sakuma1,2, Tatsuo Chiba1,3, Akira Shimoda1, Hiroki Shiratori1,Honami Suzuki1, Taiji Hidaka1, Takenori Morishita1, Ryoji Matsuda1, Sachie Takagi1,Mari Yamanaka1, Akira Sato1,2, Satoshi Kawakami1, Megumi Aimoto1, Akira Takahara11

Dept. Pharmacol. Therap., Fac. Pharmaceut. Sci. Toho Univ., 2Dept. Pharm. Toho Univ. Sakura Hosp., 3Dept.
Pharm. Toho Univ. Ohashi Hosp.

Copyright © The Japanese Pharmacological Society3-O-110 Oral Sessions
Metalloprotease Nardilysin regulates sinus automaticity throughtranscriptional regulation of ion channels.
Mikiko Ohno1, Kiyoto Nishi1, Hiroshi Matsuura2, Takeru Makiyama3, Hirohiko Koujitani3,
Shintaro Matsuda3, Takeshi Kimura3, Eiichiro Nishi1
1

Dept. Pharm. Shiga Univ. Med. Sci., 2Dept. Phisio. Shiga Univ. Med. Sci., 3Dept. Cardiovasc. Med, Grad. Sch.
Med., Kyoto Univ.

Copyright © The Japanese Pharmacological Society3-O-111 Oral Sessions
Analysis of electropharmacological effects of TASK-1 inhibitor doxapram
along with anti-atrial fibrillatory action using the intact and chronic
atrioventricular block dogs
Ryuichi Kambayashi1, Ai Goto1, Hiroko Izumi-Nakaseko1, Yoshinori Takei1, Akio Matsumoto2,
Shinichi Kawai3, Atsushi Sugiyama1,2,31

Dept. Pharmacol., Fac. Med., Toho Univ., 2Dept. Aging Pharmacol., Fac. Med., Toho Univ., 3Dept. Inflammation &Pain Control Research, Fac. Med., Toho Univ.

Copyright © The Japanese Pharmacological Society3-O-112 Oral Sessions
Development of a screening methods for Alzheimer's disease therapeuticagents based on the traffic jam hypothesis
Nobumasa Takasugi, Nanaka Kaneshiro, Masato Komai, Atsuya Ikeda, Takashi Uehara
Dept. Medicinal pharmacol. Grad. Sch. Med. Den. Pharmaceutical Sci. Okayama Univ., Japan

Copyright © The Japanese Pharmacological Society3-O-113 Oral Sessions
In vivo evaluation of novel near-infrared fluorescence probe THK565 forimaging amyloid β and tau protein deposits in Alzheimer‘s mouse models
Fumito Naganuma1, Daiki Murata1, Marie Inoue1, Ryuichi Harada2, Yukitsuka Kudo3,Tadaho Nakamura1, Nobuyuki Okamura1
1

Div Pharmacology, Fac. Med. Tohoku Med. Pharm. Univ.,2Dept Pharmacol. Grad Sch Med Tohoku Univ., 3Inst
Dept and Aging. Tohoku Univ.

Copyright © The Japanese Pharmacological Society3-O-114 Oral Sessions
Analysis of cytotoxicity via disruption of intracellular iron homeostasis inPARK9 model cell
Takanori Murakami1, Hisaka Kurita1, Isao Hozumi1, Ryo Kakiuchi2, Tasuku Hirayama2,Hideko Nagasawa2, Masatoshi Inden1
1Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ., 2Lab. Pharm. Med. Chem., Gifu Pharm. Univ.

Copyright © The Japanese Pharmacological Society3-O-115 Oral Sessions
Analysis of molecular mechanism underlying cell death induced by anALS/FTD-causative gene CHCHD10Shinya Kusakari, Yuri Kobayashi, Hiroaki Suzuki, Masaaki Matsuoka
Tokyo Med. Univ. Dept. of Pharmacol.

Copyright © The Japanese Pharmacological Society3-O-116 Oral Sessions
Effects of an intrauterine hyperglycemic environment on fetal brain neurons
Akio Nakamura1, Haruka Ookami2, Akiyo Toriumi3,4, Hitomi Yoshizaki1, Eriko Oogane1,Ritsuko Kawaharada51

Dept. of Food and Health Sci., Jissen Women’s Univ., Hino, Japan.,2Dept. of Food and Nutri., Grad. Sch. Healthand Welf., Takasaki Univ., Takasaki, Japan.,3Dept. of Mol. Epidem., Grad. Sch. Med. Dent. Sci., Tokyo Med. Dent.
Univ., Bunkyo, Japan., 4Comp. Reprod. Med., Grad. Sch. Med. Dent. Sci., Tokyo Med. Dent. Univ., Bunkyo, Japan.,5
Dept. of Health and Nutri., Takasaki Univ., Takasaki, Japan.

Copyright © The Japanese Pharmacological Society3-O-117 Oral Sessions
Electropharmacological analyses of licorice using the human induced
pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) sheets and thechronic atrioventricular block dogs
Hiroko Izumi-Nakaseko1, Koki Chiba2, Ai Goto1, Ryuichi Kambayashi1, Akio Matsumoto3,
Yoshinori Takei1, Shinichi Kawai4, Atsushi Sugiyama1,3,4
1

Dept. Pharmacol., Faculty Med., Toho Univ., 2Dept. Trad. Med., Faculty Med., Toho Univ.,3Dept. Aging
Pharmacol., Faculty Med., Toho Univ., 4Dept. Inflammation & Pain Control Research, Faculty Med., Toho Univ.

Copyright © The Japanese Pharmacological Society3-O-118 Oral Sessions
Rapid increase in aerobic glycolysis in neonatal mouse ventricularcardiomyocytes in response to acute β-adrenergic stimulation
Hiroyuki Kawagishi1,2, Tsutomu Nakada3, Takuro Tomita-Numaga2, Mitsuhiko Yamada2
1

Dept. of Biotech., Inst. for Biomed. Sci., Shinshu Univ., 2Dept. of Mol. Pharmacol., Shinshu Univ. Sch. of Med.,
3
Dept. of Instrumental Anal., Res. Ctr. for Supp. to Adv. Sci., Shinshu Univ.

Copyright © The Japanese Pharmacological Society3-O-119 Oral Sessions
Noradrenaline-induced basilar artery vasomotor response also varies inavian species (chickens and ducks)
Siyuan Wu1, Ryoya Sekio2, Henry Smith3, Mitsuya Shiraishi4, Atsushi Miyamoto1,21

Dept. Vet. Pharmacol., Joint Grad. School Vet. Med., Kagoshima Univ.,2Dept. Vet. Pharmacol., Joint Fac. Vet.
Med., Kagoshima Univ., 3Joint Grad. School Vet. Med., Kagoshima Univ., 4Dept. Vet. Physiol., Joint Fac. Vet. Med.,
Kagoshima Univ.

Copyright © The Japanese Pharmacological Society3-O-120 Oral Sessions
Gene regulation by cell-cell fusion in skeletal myogenesis.
Taichiro Tomida, Kimitaka Yamaguchi, Yoshinori Mikami, Daisuke Ohshima, Satomi AdachiAkahane
Dept. of Physiol., Sch. of Med., Fac. of Med., Toho Univ.

Copyright © The Japanese Pharmacological Society3-O-121 Oral Sessions
GPR143, an L-DOPA receptor, augments the ERK signaling via ADRA1B
through coupling between GPR143 and ADRA1B
Takahagi Ryo, Daiki Masukawa, Yoshio Goshima
Dept. of Mol. Pharmacol. & Neurobiol., Yokohama City Univ.

Copyright © The Japanese Pharmacological Society3-O-122 Oral Sessions
Heteromeric complex formation and crosstalk between type 1 metabotropicglutamate receptor and GABAB receptor
1121

Hakushun Sakairi , Yuji Kamikubo , Toshihide Tabata , Takashi Sakurai
1Dept. Pharmacol., Juntendo Univ. Sch. of med., 2Fac. Eng., Univ. Toyama

Copyright © The Japanese Pharmacological Society3-O-123 Oral Sessions
The coronavirus-related signaling pathway networks and prediction
modeling with activity plots.
Shihori Tanabe1, Sabina Quader2, Ryuichi Ono3, Horacio Cabral4, Kazuhiko Aoyagi5,Akihiko Hirose1, Hiroshi Yokozaki6, Hiroki Sasaki7
1Div. Risk Assess., CBSR, Natl. Inst. Health Sci., 2iCONM, 3Div. Cell. Mol. Tox., CBSR, Natl. Inst. Health Sci.,
4Grad. Sch. Engineer., The Univ. of Tokyo,5Dept. Clin. Genomics, FIOC, Natl. Cancer Ctr. Res. Inst., 6Dept. Path.
Grad. Sch. Med., Kobe Univ., 7Dept. Transl. Oncol., FIOC, Natl. Cancer Ctr. Res. Inst.

Copyright © The Japanese Pharmacological Society3-O-124 Oral Sessions
A mammalian target of Differentiation-inducing factor 1 is mitochondrial
malate dehydrogenase
Koichi Miura, Ruzhe Han, Takeru Inoue, Toshiyuki Sasaguri
Dept. of Clin. Pham., Fac. of Med. Sci., Kyushu univ.

Copyright © The Japanese Pharmacological Society3-O-125 Oral Sessions
Functional importance of the oligomer formation of the neuropeptide
receptor VIPR2
Satoshi Asano1,2, Kairi Ozasa2, Takanobu Nakazawa3, James Waschek A4, Yukio Ago1,21

Dept. of Cell. Mol. Pharmacol., Grad. Sch. of Biomed. Health Sci., Hiroshima Univ., 2Sch. of Dent., Hiroshima
Univ., 3Dept. Biosci., Tokyo Univ. of Agr.,4Univ. of California Los Angeles

Copyright © The Japanese Pharmacological Society3-O-126 Oral Sessions
Thromboxane A 2 receptor signaling improves secondary lymphedema andpromotes lymphangiogenesis
1

1,31,21

3Kanako Hosono , Toshiaki Mishima , Yoshiya Ito , Koh Hatanaka , Kagami Miyaji ,1,451,2Masataka Majima , Shuh Narumiya , Hideki Amano1

Dept. Pharm., Sch. Med., Kitasato Univ., 2Dept. Mol. Pharm., Grad. Sch. Med., Kitasato Univ., 3Dept. Cardiovasc.
Surg., Sch. Med., Kitasato Univ., 4Fac. Health & Med. Sci., Kanagawa Inst. Tech., 5Dept. Drug Discovery Med.,
Grad. Sch. Med., Kyoto Univ.

Copyright © The Japanese Pharmacological Society3-O-127 Oral Sessions
Involvement of histamine receptor subtypes on pollen allergy-induced
ocular itching in mice
Tsugunobu Andoh1,2, Hikari Kosaki2, Toshiaki Kume2
1

Dept. Pharmacol. Pathophysiol., College Pharm., Kinjo Gakuin Univ., 2Dept. Applied Pharmacol., Sch. Med.
Pharm. Sci., Univ. Toyama

Copyright © The Japanese Pharmacological Society3-O-128 Oral Sessions
Diversity and functional roles of G protein-coupled receptor 3 innonneuronal cells
Shigeru Tanaka1, Hiroko Shiraki1, Yun Guo2, Yuhki Yanase3, Kana Harada1, Izumi Hide1,Tomoharu Yasuda2, Norio Sakai1
1Dept. Pharmacol., Hiroshima Univ. Biomed. & Health Sci., 2Dept. Immunol., Hiroshima Univ. Biomed. & HealthSci., 3Dept. Pharmacotherapy., Hiroshima Univ. Biomed. & Health Sci.

Copyright © The Japanese Pharmacological Society3-O-129 Oral Sessions
Novel compound heterozygous variants in the SLC39A7 gene in a Japanese
girl with B-cell deficiency.
Wakana Ohashi1, Kay Tanita2, Hinata Sugiyama1, Tsubasa Okano2, Tomiko Ozaki2,Satoru Nose3,4, Yasunori Horiguchi3, Zen-ichiro Kato5, Hidenori Onishi5, Kousuke Imai6,Tomohiro Morio2, Koji Hase1, Hirokazu Kanegane7
1Div. of Biochem. Fac. of Pharm. And Grad. Sch. Of Pharmaceut. Sci., Keio University, 2Dept. of Pediatrics andDev. Biol., Tokyo Medical and Dental University,3Pediatrics, International University of Health and Welfare Atami
Hospital, 4Musashino Tokusyukai Hospital, 5Dept. of Pediatrics, Grad. Sch. of Med., Gifu University, 6Dept. ofCommunity Pediatrics, Perinatal and Maternal Med., Tokyo Medical and Dental University, 7Dept. of Child Healthand Dev. Tokyo Medical and Dental University

Copyright © The Japanese Pharmacological Society3-O-130 Oral Sessions
Profiling of the antibody response to attenuated LC16m8 smallpox vaccine
using protein array analysis
Yasuhiro Kanatani1, Akiko Eto2
1

Tokai Univ. Sch. Med. Clin. Pharmacol., 2Natl. Inst. Public Health Dept. Health Crisis Management

Copyright © The Japanese Pharmacological Society3-O-131 Oral Sessions
Attenuation of the sterile inflammation in the pulmonary epithelium bytargeting CFTR interacting molecules.
Fukuda Ryosuke
Kwansei Gakuin University, School of Biological and Environmental Sciences, Department of Biomedical Sciences

Copyright © The Japanese Pharmacological Society3-O-132 Oral Sessions
Decreased proteasomal function increases oxidative stress in the earlystage of pressure ulcer
Eri Murata1, Takuma Yoshida2, Saaki Yamamoto2, Akihiro Ishizu3, Utano Tomaru2
1

Dept. of Nursing, Faculty of Medicine & Graduate Sch. of Medicine, Yamagata Univ., 2Dept. of pathology, Facultyof Medicine & Graduate Sch. of Medicine, Hokkaido Univ., 3Dept. of Medical Laboratory Science, Faculty ofHealth Sci., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society