Kyoto University

FeatureTimeline: Ten Years of iCeMS
iCeMS Frontrunners
Towards ultra-thin wires using mathematical models
Daniel Packwood(Junior Associate Professor)
Focus on your interests to lead the way
Kouichi Hasegawa(Junior Associate Professor)

Image of molecules adsorbed to a metal copper
surface, with formulas from the field of machinelearning. When the adsorbed molecules organize
into a straight line, we can produce a wire as
fine as one-hundred-thousandth of a humanhair. Employing mathematical models, we canidentify the types of molecules predisposedto this orientation and ideal conditions for theiralignment. Turn to page 6 to read the full story.

iCeMS Fund — Help us growiCeMS in brief

Feature(Job titles as of the dates of respective events)

Timeline:

The growth of the courtyard garden marks
the swift passage of time.

Ten Years of iCeMS

Japanesemale
85Founded in 2007, iCeMS marks its 10th anniversary in 2017.
How have the seeds planted upon iCeMS’ inception grown in the past ten years?
In this article we look back on the history of iCeMS.

iCeMS selected by MEXT
as a WPI Research Center

WPI Centers : 5

iCeMS founded
The first iCeMS Seminar held
Prof. Norio Nakatsuji,
Founding Director

The Center for iPS Cell Research152

A project launched in 2007 by the
Ministry of Education, Culture, Sports,
Science and Technology (MEXT) toestablish “globally visible” institutes
with superb research environments
and high quality results. Five institutes
including iCeMS were selected as WPICenters in 2007.

National origin of overseas researchers

Piano in theiCeMS Lounge,a gift from thefounding director

The first iCeMS Café held
iCeMS Main Building

Science Communication GroupiCeMS Café

Works as a bridge between
researchers and the public. Attracted
much attention with its “Hands on
with Stem Cells!” sugoroku (Japaneseboard game) released in 2015.

An opportunity for casual dialogue
about science between iCeMS
researchers and the public in arelaxed atmonphere.

Cumulative
total

543

iCeMS

Kyoto University Main Gate

Higashi-ichijo Dori

Yoshida Shrine

Their own
beautiful voice

Outreach activities

Glossaries

55%

Flute,
Piccolo

Tenor sax

ViolinGuitar (acoustic,
electric, bass)

Piano,
Electric organ

Drums(Data as of April 1, 2016)

Tree planted
upon theinauguration of
the NCBS-inStem
Satellite. See
how tall it has
grown!

Prof. Susumu Kitagawa listed

as a Thomson Reuters Citation
LaureateT he iCeMS Satellite at the Tata
Institute of Fundamental Research
National Centre for Biological Sciences(NCBS) and the Institute for Stem Cell
Biology and Regenerative Medicine(inStem) in India opened
The 10th iCeMS Café held

International activities

98％

Musical instruments owned by researchers

Thomson Reuters
Citation Laureate

Enough to form a queue from iCeMS
to the entrance of Yoshida Shrine!

Those who
commutedby bicycle

Fish he first iCeMS retreatT(researcher’s camp) held

Participants at the 20 iCeMS Cafés to dateThose who used
stairs instead ofelevators

19％

Dogs

Overseasfemale6
Japanesefemale24iCeMS Satellite at Gifu University
established he Science Communication Group
T(SCG) formed

Fruits of research

Those
who packed
their lunch

Pets favored byresearchers

iCeMS
Main Building completed(Founding Director: Prof. Shinya Yamanaka)

The history of the instituteHamsters

CiRA establishedand Application (CiRA) establishedas part of iCeMS

2

A day in the life of researchers
Rabbits

Overseas
male
37

iCeMS’
Researchers

The World PremierInternational (WPI)
Research Center Initiative

iCeMS

iCeMS’ Reserachers

Thomson Reuters annually honors
the authors of excellent papers
cited with extreme frequency byother researchers. This serves asa clue to predicting Nobel Prizenominees!

Joint Symposiumwith Heidelberg University

 roject launched by Director NorioP
Nakatsuji et al. to achieve the practicaluse of ES cells
 ugiyama Lab developed a DNA selfS
assembly system, the “DNA origami”
method.
Joint Symposium with Heidelberg
University held in Heidelberg, Germany
DNA origami

iCeMS

WPI Centers : 6

DNA origami is the nanoscale folding of DNA strands tocreate two- or three-dimensional structures. The specificityof the interactions between complementary base pairs
makes DNA a useful
construction material.

3

Feature: Timeline: Ten Years of iCeMS(Job titles as of the dates of respective events)

Joint Symposium with the Center forLife Sciences (CLS) at Tsinghua andPeking Universities held in Beijing,
China

Microscopes
at iCeMS:

New Director
appointed

Karolinska Institute and others
Prof. Shinya Yamanaka

awarded the Nobel Prizein Physiology or Medicine

iCeMS

WPI Centers : 9More Info!

Press conference
upon Nobel Laureate
announcement

The developed porous coordination polymers (PCPs)
were assembled using metal
ions and organic links, which
possess framework structureswith one nanometer porosity.
Nitric oxide
trapped in
pores
can
be released
on-demandby light irradiation.

Government subsidies over the past 10 years

The biggest purchase

JPY

Leica Microsystems TCS SP5 STED
(Stimulated Emission Depletion)

The height in stacked one-yen coins:Price :

Approx.

JPY

12,739,467,588.19,109,000 meters

5,060

about
times
as high as Mt. Fuji

京都市営バス「京大正門前」
停留所から
京都市営バス「京大正門前」
停留所から

From
Kyoto 「京大正門前」
City Bus Kyodai
Seimon-mae stop :京都市営バス
停留所から

156

Co-hosted the World Stem Cell
Summit 2013 (Florida, USA) with
Joint Symposium(Beijing)

Access to iCeMS Main Entrance

Prof. Susumu Kitagawa,Director

京都大学正門から京都大学正門から
From
the Kyoto University Main Gate :京都大学正門からBiomaterials Science
From
the KeihanLine Demachiyanagi Station :京阪電鉄
出町柳駅から
京阪電鉄
出町柳駅から
京阪電鉄
出町柳駅からProf. Susumu Kitagawa appointed as

new Director of iCeMS(Data as of April 1, 2016)“ Biomaterials Science” journal, co-published with
the Royal Society of Chemistry (RSC), launched“ The Chemistry of Life” online edX
lecture opened by Prof. Motonari
Uesugimolecules in response to lightirradiation developed by the research groupled by Assoc. Prof. Shuhei Furukawa, Asst. Prof.
Stéphane Diring and Director Susumu Kitagawa

138,390,000.-

This “superresolution
microscope”
was developedby 2014 Nobel
Prize Laureate
Dr. Stefan
Walter Hell. It
visualizes detailed cellular structures and functions
at a spatial resolution of more than 100 nanometers(ten-thousandth of one millimeter).

E-MRS

The Gozan Okuribi
bonfire observable frommountains
iCeMS

Funagata
MandoroHidari
DaimonjiMatsugasaki
Myo-HoiCeMS

Daimonji

1,418
steps

Lecture by Prof. Jean-Marie Lehn

 igning of the partnership agreement withS
Vidyasirimedhi Institute of Science andTechnology (VISTEC), Thailand

Special lecture by Prof. Jean-Marie
Lehn, a Nobel Laureate in ChemistryPorous materials that release gas◦Daimonj ◦Hidari Daimonji◦Funagata Mandoro◦Matsugasaki Myo-Ho (Ho)

283
steps

200th iCeMS Seminar he 10th Japan-France Workshop on
T
Nanomaterials and the first WPI Workshop
on Materials Science (Kyoto) co-hosted byfour WPI Centers in material science and Le
Centre national de la recherche scientifique(CNRS), France

4

10
steps

 our WPI institutes in materialF
science participated in theEuropean Materials ResearchSociety (E-MRS) 2016 Spring
Meeting (Lille, France)
Assoc. Prof. Easan Sivaniah’s groupdeveloped superior gas separation
membrane materials.

edX Lectures
Free online courses from morethan 20 world-leading universities,
including MIT and Harvard. iCeMS
was the first Japanese institute to join
this project. Around 26,000 students
have taken Prof. Uesugi’s lecture.

More Info!
Gas separation membranes are atechnology proposed to separate carbon
dioxide from exhaust gases. The teamhas successfully developed membranematerials
which
exhibitsuperior
properties and greater durability at alower cost than conventional membranes.

Her Royal Highness Princess Maha Chakri

Sirindhorn of Thailand visited iCeMS
More Info!

Princess Sirindhorn visiting iCeMS

 ssoc. Prof. Tatsuya
A
Murakami’s groupdeveloped a lightinduced method
for controlling pain
sensations in single
neuronal cells.

When illuminated by near-infrared light, rodshaped gold nanomaterials are capable ofhighly efficient heat generation. Engineering
the surface of these nanomaterials withserum proteins effectively and safely
delivers them to the plasma membraneof sensory neurons. Upon illumination of
the gold-nanomaterial-bound cells, TRPV1,
the primal heat-sensitive nociceptor
in our body, can be locally heated toinduce a pain signaling. This is the first
demonstration of remote control of TRPV1
in intact neuronal cells.

First Learning Lounge held
→ See page 11 for details

Workshops linked to the “Think
Like a Crow!” TV program on NHK
Educational“Think Like a Crow!”
linked workshop

“Our World, Your
Future” newsletterlaunched
iCeMS Retreat(researchers’ camp)

45

Interview

iCeMS Frontrunners

2

A central processing unit (CPU), the brain of a computer, has eight billion transistors arranged on a fivecentimeter square substrate. Each transistor is about 20 nm, almost five thousandth the diameter of ahuman hair. Such minuscule and sensitive electronics require nanofabrication techniques to assemble
and align atoms and molecules. Daniel Packwood has successfully developed such synthesis methods
by utilizing theoretical chemistry that explain intricate molecular actions with mathematical models.

Towards ultra-thin wires
using mathematical models
Daniel Packwood
Junior Associate Professor

Daniel Packwood
Born in 1985 in Christchurch, New Zealand. Completed
his PhD in chemistry at the College of Science of the
University of Canterbury in 2010 and came to Japan asa chemistry postdoc of the Kyoto University Graduate
School of Science. Has remained in his present position
since 2016, after working for the Advanced Institute forMaterials Research (AIMR) at Tohoku University.

6

In contrast to his mastery ofmathematics
today,
Packwood
did not excel academically before
entering the university. He barely
passed the college entrance examin New Zealand. “I struggled inmathematics, and I gave up learning
Japanese - I had only chosen it
because I was a big Super Nintendo
fan [laughs].”
Friends’ remarks
motivatedyoung Packwood. “Friends of mine
said that math and chemistry would
be too difficult for me. It was justa casual comment, but I felt insulted
at that time for my scores wereactually low.” Packwood studied
hard to prove his friends wrong andawakened to the appeal of chemistry
and mathematics.

Charms of iCeMS: High-levelresearch and flexible crossdisciplinary approaches
Packwood originally sought a
research position in the West, but aconference in Japan opened his eyesto the high level of research here. “I
immediately contacted a laboratory at
Kyoto University.” After spending one
and a half years in Kyoto, he moved to
the Advanced Institute for Materials
Research (AIMR) at Tohoku
University, another World PremierInternational Research Center. Since
April 2016, he has been a member ofiCeMS.
Packwood feels that the unparti­
tioned laboratories of iCeMS permit
cross-disciplinary
communications.
“Sometimes my fellow researchers ask

for my comments on fresh experimental
data. New ideas occur to me one after
another as I talk with them.”

Next-generation wires as fineas one hundred-thousandth
the size of a human hair

Packwood focuses on the studyof “molecular self-assembly,” aphenomenon seen in the growthof snow crystals or double-helicalDNA, where molecules naturallyorganize into functional structures.
He aims to apply this mechanism
to nanotechnology. “If molecules
lie on a straight line and become
organized, we should be able toproduce a wire as fine as one hundredthousandth the size of a human hair.
This will definitely contribute to theminiaturization of electronic devices.”
Utilizing predictions from an original
mathematical model, Packwood has
successfully identified the types ofmolecules predisposed to form straightlines, along with ideal temperature
conditions for alignment. His
The diameter
1/5,000
of a human hair（approx. 100 μm） of the diameterof a human hair
Transistor（20 nm）

Mitochondrion（approx. 1 μm）

DNA（approx. 1 nm）

achievements promise to lessen theneed for time-consuming and costly
experiments, a rewarding step forward.
While a few of his findings stillrequire validation with experimental
data, Packwood is quite optimistic.
“iCeMS has an environment forcollaboration, so I can readilydemonstrate my theory throughexperiments. I am sure my study willbear more and more fruits from now.
I hope to perfect a real product while
being here at iCeMS.”

Developing mathematicalformulas in his headPen, paper, and a computer are
all Packwood needs to conduct basic
research. He has filled hundreds
notebooks since college. “I can write
formulas in my head these days.
Equations are like good friends to me.
I memorize their every feature, justlike I remember names, faces, voices.”
Sometimes he even starts calculations
in his head. “Thinking about research
all the time is part of being a researcher.

At Koiwai Farm in Morioka, Iwate, in
September 2014. Packwood has visitedmany places in Japan, from Wakkanai in thenorth to Nagasaki in the south. He particularly
loves countryside richly endowed with nature.
“Contact with nature makes me feel humanagain!”

It’s the same as monks, who are monks
all the time.”
Packwood says that he felt
more stress about his research in his
twenties because of then-insufficientknowledge and experience to identify
research targets. “But now, in mythirties, I have a broader range of
methodologies to utilize, andcan find solutions more quickly
A wire calculated as feasible
than before. And my research
by Packwood’s models
outcomes make my work all
the more interesting. Researchmolecules
involves continual hardships
1/100,000 of the diameter
1/200,000 of the diameterwith days of repeated failures,of a human hairof human a hair
but once it bears fruit, it is verysatisfying!”
7

Interview

iCeMS Frontrunners

3“Animals have so many different shapes. How interesting!” Hasegawa’s boyhood excitement motivates
him even today. Driven by curiosity, he maintains a stance of “doing what I like”, which now isinvestigating the mystery of animal body formation through stem cells. Stem cells can “differentiate”
into various types of tissues/organ cells. Understanding and controlling such differentiation contributes
innumerably to fields such as regenerative medicine and drug development. Fascinated by this quest,
Hasegawa energetically pursues research in Japan, India and Australia.

Focus on your interests
to lead the way
Kouichi Hasegawa
Program-Specific Research Center Junior Associate Professor“Why do animals look so different
from each other?” This simple question
was how Hasegawa, born and raised close
to nature in Tamana City of Kumamoto
Prefecture, started towards research.

Hoping to study only animals

Kouichi Hasegawa
Born in 1972 in Kumamoto, Japan. Graduated from
Hiroshima University in 1995, with major in zoology
from the Department of Biological Science. Received a
PhD in 2000 from Kwansei Gakuin University Graduate
School of Science. Held positions as Researcher with
Institute for Frontier Medical Sciences, Kyoto University
and Assistant Professor at Department of Cell and
Neurobiology, University of Southern California. Has
served as Junior Associate Professor of iCeMS
Satellite at NCBS-inStem and Assistant Professor of
NCBS-inStem in India since 2011, as well as SeniorResearcher with Faculty of Medicine, Dentistry and
Health Sciences, University of Melbourne since 2014.
Works as an advisory board for some entrepreneurial
ventures.

8

Hasegawa prioritizes what he likes,
so much that people ask, “How can
you be so careful in your experiments
while being so careless about yourdaily life?” For this reason, he chose
Hiroshima University, where he could
specialize in zoology from year one.
Hasegawa’s study convinced himthat organized development was key
to understanding animal morphology.
Consequently, he wanted to conduct
graduate study with Prof. Tsutomu

Kinoshita. Just then, however, Prof.
Kinoshita was promoted to Kwansei
Gakuin University, where chemistry was
mandatory in the postgraduate exam.
Hasegawa, obsessed with biology, had
hardly studied chemistry, but he stillwanted to join. He intensely studied,successfully passed the chemistry exam,
and realized his ambition to study
embryology under Prof. Kinoshita. “He
drilled into me the ABCs of research,
including how to formulate a question,
perform experiments and write a thesis
and scientific manuscripts.”

Encountering stem cellresearch and working
overseas

In 2000, when Hasegawa
completed his doctorate, Japan had

scarce job openings. To pursue research
further, rather than job hunting,he joined Dr. Norio Nakatsuji’slaboratory, then at the Institute for
Frontier Medical Sciences, Kyoto
University. “At first I was in chargeof preparing genetically engineered
mice. As Prof. Nakatsuji recognized
my experimental skills, I transitioned
to deriving embryonic stem (ES) cells
for monkey and human embryos.”Years later, at Prof. Nakatsuji’s
suggestion, Hasegawa applied to the
A stained embryo
at initial cellulardifferentiation fromafertilized
egg;
futuresomatic
cells in green are
distinguish­able fromfuture placenta cells
in red.

Hasegawa at a wedding with his colleagues
in India. “Experiencing diverse culturesand perspectives in India is quite fun andhelps me in expanding my views—though
it does often bring conflicts to my work.”laboratory of Prof. Martin Pera, arenown stem cell researcher. Prof.
Pera was just leaving Australia to workin the United States, so Hasegawa
followed him to the University ofSouthern California. There, under
Prof. Pera’s influence, he establishedhis research style and mastered
American research grant applications.

Traveling and researchacross three countries

In the aftermath of the economiccrisis of 2008, Hasegawa was calledback to Japan by Prof. Nakatsuji,
then director of iCeMS. He asked
Hasegawa to launch an iCeMS satellite
laboratory at the National Centre for
Biological Sciences (NCBS) in India.
“I was quite puzzled, but I am not akind of person who rejects someone’s
requests [laughs].”
NCBS had ample start-up funds,
but its facilities were still underconstruction. Kyoto, on the other hand,
had facilities but not enough researchfunds for Hasegawa at the mid-year.
He was at a loss as to how to proceed
when Prof. Pera contacted him to ask
for help launching a laboratory at the
University of Melbourne. Hasegawa
immediately accepted his request andheaded for Australia. “The start-up
was certainly a hard work, but I wasable to use an adjacent lab to conduct
my experiments in my spare time. The

Hasegawa loves motorcycling. Driving
through the American wilderness offersa chance to re-examine himself incomparison to the greatness of nature.

three months I spent there were very
fulfilling, and I successfully completed
two papers.”
Since then, Hasegawa is mainly
based in Kyoto and India, flying backand forth between the two almost
monthly and visiting Australia ona regular basis. “In fact, I just cameback from India yesterday! I conduct
my research in those three places, butwhat I do is totally different because
each location has its own facility
condition, fund status and research
climate.” In Kyoto, he conducts basic
research on stem cells, whereas in India
he utilizes stem cell differentiation to
search for cures for malaria or otherdiseases. “Now that I have a base in
India, I definitely want my research tohelp Indian people. And I also hopethat my basic research in Japan, as afoundation for medical treatment andtechnology, will help many patients.”
9

iCeMS Fund - Help us grow
At iCeMS, we develop new insights into the principles of lifethat distinguish living things from non-living things, and harness
these ideas to create bio-inspired super materials and devices
that will revolutionize health-care, medicine, industry and theEnvironment to create a sustainable world for us all.
Whilst much of the work we do here is Pure Science, we areabsolutely certain that our research combining high-level chemistry,cell biology and physics, at the border between materials and life, will
meaningfully impact the world in which we live.
The research we carry out at iCeMS will help doctors to fightsuch perennial problems as heart disease, cancer, and degenerative

iCeMS in brief
brain conditions, as well as develop invaluable new medicines andtherapies. Our revolutionary work also addresses key issues suchas global warming, pollution, over-dependency on fossil fuels, andthe availability of clean drinking water.
Generous gifts from donors like you provide the financial andmoral support needed to continue and develop this research at
the cutting edge of modern science. We are not merely content toimprove existing technologies, but seek to affect paradigm shifts
in the way science may benefit humanity.
Help us to help the world. Together we can make a difference
because we care.

Individuals

Donations

Corporations /Organizations

Contribution
tohealthcare

Activities that
contribute tosocietyiCeMS Fund

A unique device to create a small and optimal 3D environment
for human pluripotent stem cells
The research group led by Prof. Yong Chen and
Assoc. Prof. Ken-ichiro Kamei have developed amicrofluidic device with a number of advantages
for controlling cellular microenvironmental
factors. A thermo-responsive hydrogel, which
can transform between solution and gel bychanging temperature, combined with themicrofluidic device allows for the creation of an
artificial 3D cellular microenvironment for hPSC
culture and analysis.

The microfluidic device (1 cm length, 1 mm
width, 200 μm height)

The research group led by Profs. Makoto
Kiso, Akihiro Kusumi and Assoc. Prof.
Kenichi Suzuki have observed raft domains—active sections of the cell membrane—inlive cells for the first time. They observed
how gangliosides form raft domains withcholesterols and a special receptor protein,
CD59, from the class of GPI-anchored
receptors. Now, researchers can begin to
investigate how toxins, bacteria and viruses
invade cells through these raft domains.

Kyoto University Fund webpage

http://www.en.kikin.kyoto-u.ac.jp/funds-in-operation/icems/

The “Learning Lounge” features young scientists
who deliver a 20-minute presentation to persuade
any curious listener, even those without a scientificbackground, that their research area is important to
the world. Each talk is recorded and when possible,
publicized online. You can watch Learning Lounge
talks by visiting the following URL;
http://www.icems.kyoto-u.ac.jp/en/community/lounge/
You are welcome to join the Learning Lounge. No
registration is required. Please check our website fordetails.
#1 - June 29, 2015
Dr. Ken-ichiro Kamei “My Life as A Microchip”*
Dr. Koh Nagata “What Did You Eat Yesterday? —How toManage Your Cholesterol”*#2 - August 3, 2015
Dr. Ganesh Pandian Namasivayam “Nature-inspired Cure for
the Incurable—Coming Soon?”*Dr. Marcel Hörning “What is a Heart Attack?”*#3 - October 21, 2015
Dr. Aya Sato-Carlton “How Is Your DNA Passed Onto YourChildren?”*Dr. Hideki Hirori “Making Invisible Worlds Visible”*#4 - November 19, 2015
Dr. Yuta Takano “Powering the People with Nano Solar Cells”*
Dr. Yoji Kojima “Decoding the Keys of Our Life Cycle”*

An illustration of HIV/AIDS viruses surrounding and attacking a host cell
Copyright : William Roberts/123rf

What’s new?

SupportResearches
iCeMS

10

Research Highlights

New fluorescent probes help solve cell membrane mystery

Solve social
issues

Producing promisingscientists of the next
generation“Learning Lounge”

Extension Lectures for High SchoolStudents: iCeMS Caravan’s “TheMechanism for Learning”
Young iCeMS researchers conducted an
active-learning educational program for highschool students called “iCeMS’ Caravan.”Starting with an ice-breaker
The Caravan attempts to provide high school
students with a chance to experience the process of transforming knowledge into
wisdom, conveying ideas to other people, and the “mechanisms for learning” thatare hidden in these processes. At the beginning of each session, researchers
provide basic knowledge. The students then create their own ideas through group
work, finishing with an easy-to-understand presentation that follows the structureof scientific manuscript.

#5 - February 25, 2016
Mr. Hirotaka Nakatsuji “Golden Rods & Guided Robots: Your
‘Nano Doctors’ Healing from Within”*
Ms. Ikumi Oomoto “Seeing is Believing; What Happens in the
Brain?”*#6 - March 31, 2016
Dr. Akihisa Yamamoto “Sticky Moments in Biology”*
Dr. Georgia Kafer “Protecting Your DNA Code”*#7 - Apri 27, 2016
Dr. Kouichi Hasegawa “Making Malaria the Last Century’s
Problem”*
Dr. Daniel Packwood “Nanotechnology by Herding Molecules—Hints from Theory”*#8 - July 28, 2016
Dr. Ayami Joh “Every Little Bit Counts in Human Interaction”
Dr. Alfonso Avila-Robinson “Seeing the Dynamics of Science
Convergence”#9 - September 28, 2016
Dr. Patrick Larpent “Nano-Pockets to Trap Carbon Dioxide”
Dr. Wan-Ting Hong “Zoo from Lorises’ Point of View”#10 - November 24, 2016
Dr. Junjun Li “Catch Me If You Can”
Dr. Yoshihiko Fujita “Gene Switch: Asking Cells, ‘Who are You?’”* Marked talks can be watched on the web.

11

Explore the secrets of life and innovate for the good of society

iCeMS’ Mission- Explore the secrets of life by creating compounds to control cells- Create life-inspired new materials for the future
Global warming. Pollution. Disease. Aging. These major concerns
can no longer be countered by traditional single disciplinebased research. At iCeMS, cell biologists, biophysicists, chemists,
material scientists, physicists, and bioengineers share ideas andwork together to devise new ways to integrate cells and materials,
all for the greater good. We find inspiration through collaboration.
We leverage our critical mass of scientific and technologicalknowledge into purposeful, transformative innovations for thepractical benefit of society.
Size of meso-scale materials

Chemical
Biology
TissueEngineering

Comparison withfamiliar things…

Molecule

Sesame(2 mm)

Biophysics

Mesoscopic Domain

〜１ nm

Cells

Vol.3
2017 January

Cell Biology

ScienceCommunication

Watermelon(20 cm)〜１ µm

Water ball
(2 m)

Medicine

iCeMS
Our World, Your Future

Materials
Science

Environment andEnergyProduction Institute for Integrated Cell-Material Sciences at Kyoto University, Yoshida
Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan
Phone: +81-(0)75-753-9755 | Fax: +81-(0)75-753-9759
E-mail: info@icems.kyoto-u.ac.jp
Homepage: http://www.icems.kyoto-u.ac.jp
Production/cooperation: Kyoto Tsushinsha Press, Design: Takayoshi Nakasone

Innovation