TECHNICAL
DATA
SHEET

Fluorescent Imaging Agent
Caution: For Laboratory Use. A product for research purposes only.

AngioSense® 680 EX
Product Number: NEV10054EX

DESCRIPTION: AngioSense® 680 EX is a fluorescent in vivo blood pool imaging agent. AngioSense® 680 EX is a nearinfrared labeled fluorescent macromolecule that remains localized in the vasculature for extended periods of time and enables
imaging of blood vessels and angiogenesis.

MATERIAL: (Needs to be reconstituted)
CONTENTS: Each vial contains 24 nmol of AngioSense® 680 EX as a lyophilized solid. The solution of AngioSense® 680
EX has been filtered through a 0.2 µm filter prior to lyophilization. Upon reconstitution with 1.2 mL of 1 x PBS, this material
provides sufficient reagent for imaging approximately 10 mice (weighing ~25 grams each) when using the recommended doseof 2 nmol/100 µL 1xPBS of AngioSense® 680 EX per mouse.

PROPERTIES: The physical properties of AngioSense®

680 EX can be found in Table 1 and Figure 1.

STORAGE & HANDLING:


Upon receipt, AngioSense® 680 EX should beIMMEDIATELY STORED AT -20 oC ANDPROTECTED FROM LIGHT.
When stored and handled properly, AngioSense®
680 EX is stable for up to six months from thedate of shipment.
Once reconstituted, the PBS solution is stable up
to 10 days when stored at 2-8 ºC and protectedfrom light.

Table 1. AngioSense® 680 EX Properties
Property
Specification
MW~ 70,000 g mol-1
Fluorescence1
 Excitation
670 nm Emission
690 nm1
Absorbance
673 ±10 nm
Purity2>90%
AppearanceBlue solid
1.
2.

Absorbance, excitation, and fluorescence maxima of AngioSense®
680 EX in 1xPBS.
As determined by SE-HPLC and measuring absorbance at 680
nm.

Fig 1. Abs/Em Spectra of AngioSense® 680 EX in 1xPBS
1IN VIVO IMAGING & APPLICATIONS:Page 1 of 3

The recommended procedure for in vivo imaging
with AngioSense® 680 EX is administration via tailvein injection and imaging 24 hours post
injection.
Imaging in Oncology: AngioSense® 680 EX canbe used to study angiogenesis, as a marker forblood vessel density, in animal tumor models.
Imaging in Arthritis: AngioSense® 680 EX can beused to characterize vascular changes andtherapeutic responses associated with animalmodels of arthritis.

0.5
0500

600

700

Wavelength (nm)800

NOTES:
PerkinElmer’s AngioSense® 680 EX is intended for research purposes only and is not for human use. It must be
used by or directly under the supervision of a technically qualified individual experienced in handling potentiallyhazardous materials. Please read the Material Safety Data Sheet (MSDS) provided for this product.

Several of PerkinElmer products and product applications are covered by U.S. and foreign patents and patents
pending. Our products are not available for resale or other commercial uses without a specific agreement withPerkinElmer.

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