22.Leprosy Research Center(Department of Mycobacteriology)

Mycobacterium leprae isolates from Brazilian relapsed
leprosy patients. J. Clin. Microbiol., 50: 1912-1917,
2012. Rocha A. S., Cunha M. G., Diniz L., Salgado C.,
Aires M. A., Nery J. A., Gallo E., Miranda A.,

1)

Critical role of AIM2 in Mycobacterium tuberculosis

Magnanini M., Matsuoka M., Sarno E., Sufys P., andinfection. Int. Immunol., 24: 637-644, 2012. Saiga H.,

Oliveira M.

Kitada S., Shimada Y., Kamiyama N., Okuyama M.,

2)

3)

Makino M., Yamamoto M., and Takeda K.

sporadic case in Japan. J. Dermatol., 39: 569-572, 2012.

Present situation of leprosy in Japan, 2006-2010:

Otsuki T., Izaki S., Nakanaga K., Hoshino Y., Ishii N.,

Analysis of drug resistance in new registered andand Osamura K.

relapsed cases by molecular biological methods. J.

11) Buruli ulcer accompanied by pain in a Japanese patient. J.

Dermatol. Sci., 67: 192-194, 2012. Mori S., Yotsu R. R.,

Dermatol., 39: 869-870, 2012. Onoe H., Yotsu R.,

Suzuki K., Makino M., and Ishii N.

Nakanaga K., Hoshino Y., Ishii N., and Takeuchi T.

Mycobacterium shigaense sp. nov., a novel slowly
growing4)

scotochromogenic

mycobacteriumthat8)

Mycobacterium

infection.

J.

Hoshino Y., Suzuki K., and Ishii N.

disease. J. Dermatol., 39： 389-396, 2012. Nakanaga K.,

13) Detection of antibiotic resistance in leprosy using

Hoshino Y., Wakabayashi M., Fujimoto N., Tortoli E. ,GenoType®LepraeDR, a novelready-to-use molecular

Makino M., Tanaka T., and Ishii N.

test. PLoS Neg. Trop. Dis., 6: e1739. doi:10.1371, 2012.

Mycobacterium pseudoshottsii isolated from 24 farmed

Cambau E., Nevejans A. C., Tejmar-Kolar L., Matsuoka

fishes in western Japan. J. Vet. Med. Sci., 74: 275-278,

M., and Jarier V.
14) Genotyping of Mycobacterium leprae in Myanmar andA., Wada S., Hatai K., Makino M., and Ishii N.

supposed transmission mode. Japn. J. Lepr., 81: 191-198,

Mutation analysis of mycobacterial rpoB genes and2012. Khin S. A., Yin T. N. O., Kyaw K., Aye A. W., andrifampicin resistance using recombinant Mycobacterium

Matsuoka M.

Antimicrob.

AgentsChemother.,

56:15) Impact of amino acid substitution in B subunit of DNA

2008-2013, 2012. Nakata N., Kai M., and Makino M.

gyrase in Mycobacterium leprae on fluoroquinolone

Essential role of hormone-sensitive lipase (HSL) in theresistance. PLoS Negl. Trop. Dis., 6: e1838, 2012.

maintenanceYokoyama K., Kim H., Mukai T., Matsuoka M.,oflipidstorageinMycobacterium

Nakajima C., and Suzuki Y.

285-291. 2012. Tanigawa K., Yan D., Kawashima A.,

16) A case of mycobacterial skin disease caused byAkama T., Yoshihara A., Ishido Y., Makino M., Ishii N.,

Mycobacterium peregrinum, and a review of cutaneousand Suzuki K.

infection, Case Reports. Dermatology, 4: 76-79, 2012.

Amino acid substitutions at position 95 in GyrA can add

Kamijo F., Uhara H., Kubo H., Nakanaga K., Hoshino Y.,

fluoroquinolone resistance to Mycobacterium leprae.

Ishii N., and Okuyama R.

Antimicrob. Agents Chemother., 56: 697-702, 2012.

17) Bacteremia due to Mycobacterium massilinese in aYokoyama K., Kim H., Mukai T., Matsuoka M.,

patient with chronic myelogenous leukemia: case report.

Nakajima C., and Suzuki Y.

Diagn. Microbiol. and Infect. Dis., 74: 183-185, 2012.

Real-time PCR and high resolution melt analysis forHamamoto T., Yuki A., Naoi K., Kawakami S., Banba Y.,

rapid detection of Mycobacterium leprae drug resistance

Yamamura T., Hikota R., Watanabe J., Kimura F.,

mutations and strain types. J. Clin. Microbiol., 50:

Nakanaga K., Hoshino Y., Ishii N., Shimazaki H.,

742-753, 2012. Li W., Matsuoka M., Kai M., Thapa P.,

Nakanishi K., and Tamai S.

Khadge S., Hagge D. A., Brennan P. J., and Vissa V.
9)cutaneous

cellular immunodeficiency and a history of Hodgkin’s

leprae-infected macrophages. Microb. Pathog., 52:7)

emerging

Dermatol., 39: 587-593, 2012. Yotsu R. R., Nakanaga K.,

smegmatis.

6)12) Buruli ulcer and current situation in Japan: a new

produced nodules in an erythroderma patient with severe

2012. Nakanaga K., Hoshino Y., Hattori Y., Yamamoto

5)10) Cutaneous Mycobacterium massiliense infection: aDrug

andmultiple-drug

ResistanceAmong18) A case of Mycobacterium haemophilum infection in aJapanese renal transplant patient and a review ofJapanese cases. J. Dermatol.,39:968-969, 2012. Takeo N.,
Hatano Y., Okamoto O., Saruwatari K., Nakanaga K.,Ishii N., Yokoyama S., and Fujiwara S.
19) The polyketide synthase-associated multidrug tolerance
inMycobacterium

intracellulare

clinicalisolates.

Chemotherapy, 58,341-348,2012. Matsunaga I, Maeda S,
Nakata N, and Fujiwara N.
20) Genotyping of Mycobacterium leprae in Myanmar andsupposed transmission mode. Japn. J. Lepr., 81:191-198,
2012. Khin S.A., Yin T.N.O., Kyaw K., Aye .A. W.,
Matsuoka M.
21) Impact of aminoacid substitution in B subunit of DNA
gyrase in Mycobacterium leprae on fluoroquinolone
resistance. PLoS. Negl. Trop. Dis., 6: e1838. 2012.
Yokoyama K., Kim H., Mukai T., Matsuoka M.,
Nakajima C., Suzuki Y.
22) Anti-viral and anti-bacterial activities of an extract of theBlackcurrant (Ribes nigrum L.). Microbiol. Immunol.,
56:805-809.2012. Ikuta K., Hashimoto K., Kaneko H.,
Mori S., Ohashi K., and Suzutani T.
23) Clofazimine

modulates

theexpressionoflipid

metabolism proteins in Mycobacterium leprae-infectedmacrophages. PLoS. Negl. Trop. Dis., 6: e1936, 2012.
Degang Y., Akama T., Hara T., Tanigawa K., Ishido Y.,Gidoh M., Makino M., Ishii N., and Suzuki K.
24) Buruli ulcer and mycolactone-producing mycobacteria.
Jpn. J. Infect. Dis., 66: 83-88, 2013. Nakanaga K., Yotsu
R. R., Hoshino Y., Suzuki K., Makino M., and Ishii1 N.
25) Laboratory

procedures

foridentificationofcutaneous

nontuberculous

mycobacterial(NTM)

infections.

J.

40:151-159, 2013. NakanagaR., Makino M., and Ishii N.

theK.,

detectionanddermatol.,

Hoshino Y., Yotsu