2. Department of Virology II
1)Infectious Diseases, 67: S42-S50, 2018

Athiyyah AF, Utsumi T, Wahyuni RM, Dinana Z,

5)

Cooper G, Mao Q, Crawt L, Wang Y, Dougall T,

Yamani LN, Soetjipto, Sudarmo SM, Ranuh RG,

Rigsby P, Liang Z, Xu M, Collaborative Study G,

Darma A, Juniastuti, Raharjo D, Matsui C, Deng L,

Minor P, Wang J Martin J. Establishment of the 1st

Abe T, Doan YH, Fujii Y, Shimizu H, Katayama K,

WHO International Standard for anti-EV71 serum

Lusida MI, Shoji I. Molecular Epidemiology and(Human). [Shimizu H, contributed as one of theClinical Features of Rotavirus Infection Among

Collaborative Study Group members] . Biologicals

Pediatric Patients in East Java, Indonesia During

53: 39-50, 20182015-2018:

Dynamic

Changesin

Rotavirus

Genotypes From Equine-Like G3 to Typical Human

6)

G1/G3. Front Microbiol 10, 2019

Deng L, Gan X, Ito M, Chen M, Aly HH, Matsui C,
Abe T, Watashi K, Wakita T, Suzuki T, Okamoto T,
Matsuura Y, Mizokami M, Shoji I, Hotta H.

2)

Bai H, Shiota T, Yoshizaki S, Saito-Obata M, Malbas

Peroxiredoxin 1, a Novel HBx-Interacting Protein,

FF Jr, Lupisan SP, Oshitani H, Takeda N, Muramatsu

Interacts

M, Wakita T, Ishii K, Li TC. Detection of

Negatively Regulates Hepatitis B Virus (HBV)

Subgenotype IA and IIIA Hepatitis A Viruses in

Propagation through Degradation of HBV RNA. J

Rivers Flowing through Metro Manila, theVirol. Mar 5;93(6); e02203-18 (2019).

with

ExosomeComponent

5

andPhilippines. 2018. Jpn J Infect Dis. 72:53-55. (2019)7)3)

Fujii Y, Doan YH, Suzuki Y, Nakagomi T, Nakagomi

Bauri M, Wilkinson AL, Ropa B, Feldon K, Snider CJ,

O, Katayama K. Study of Complete Genome

Anand A, Tallis G, Boualam L, Grabovac V, Avagyan

Sequences of Rotavirus A Epidemics and Evolution

T, Reza MS, Mekonnen D, Zhang Z, Thorley BR,

in Japan in 2012-2014. Front Microbiol. 10:38, 2019

Shimizu H, Apostol LNG Takashima Y. Notes fromthe Field: Circulating Vaccine-Derived Poliovirus

8)

Fujii Y, Doan YH, Wahyuni RM, Lusida MI, Utsumi

Type 1 and Outbreak Response - Papua New Guinea,

T, Shoji I, Katayama K. Improvement of Rotavirus

2018. MMWR Morb Mortal Wkly Rep 68: 119-120,

Genotyping Method by Using the Semi-Nested

2019

Multiplex-PCR

With

New

PrimerSet. Front

Microbiol. 2019, 10:647.
4)

BrickleyEB,

Wieland-AlterW,

ConnorRI,

Ackerman ME, Boesch AW, Arita M, Weldon WC,

9)

Fujii

K, Sudaka Y, Takashino A, Kobayashi K,

O’Ryan MG, Bandyopadhyay AS, Wright PF.

Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O,

Intestinal

Following

Ami Y, Shimizu H, Nagata N, Mizuta K, Matsuzaki Y,

Polio

Koike S. VP1 amino acid residue 145 of enterovirus

Vaccine/Bivalent Oral Polio Vaccine and Trivalent

71 is a key residue for its receptor attachment andInactivatedresistance

Sequential

Immunityto

Trivalent

Polio

Poliovirus
InactivatedVaccine-only

Immunization

Schedules: Analysis of an Open-label, Randomized,
Controlled

Trial inChileanInfants. Clinicaltoneutralizing

antibody

duringcynomolgus monkey infection. J Virol May 201810) Fukano K +, Tsukuda S +, Watashi K, Wakita T.

16) Kaneko M, Do LP, Doan YH, Nakagomi T, Gauchan

Concept of Viral Inhibitors via NTCP. Semin Liver

P, Agbemabiese CA, Dang AD, Nakagomi O.

Dis. 2019. 39(1): 78-85. ( +equally contributed)

Porcine-like G3P[6] and G4P[6] rotavirus A strains
detected from children with diarrhoea in Vietnam.

11) Fukano K, Tsukuda S, Oshima M, Suzuki R, Aizaki

Arch Virol 163:2261-2263, 2018

H, Ohki M, Park SY, Muramatsu M, Wakita T,
Sureau C, Ogasawara Y, Watashi K. Troglitazone17) Kato T, Hasegawa M, Yamamoto T, Miyazaki T,

impedes the oligomerization of sodium taurocholate

Suzuki R, Wakita T, Suzuki T, Park EY. Expression

cotransporting polypeptide and entry of hepatitis Bof a functional intrabody against hepatitis C virus

virus into hepatocytes. Front Microbiol. 2019. 8; 9:core protein in Escherichia coli and silkworm pupae.

3257.

Protein Expr Purif. 150:61-66 (2018)12) Funakoshi Y, Ito K, Morino S, Kinoshita K,18) Kitagawa K, Kuniya T, Nakaoka S, Asai Y, Watashi

Morikawa Y, Kono T, Doan YH, Shimizu H, Hanaoka

K, Iwami S. Mathematical analysis of a transformed

N, Konagaya M, Fujimoto T, Suzuki A, Chiba T,

ODE from a PDE multiscale model of hepatitis C

Akiba T, Tomaru Y, Watanabe K, Shimizu N,

virus infection. Bull Math Biol 81(5): 1427-1441

Horikoshi Y. Enterovirus D68 respiratory infection in(2019)

a children's hospital in Japan in 2015. Pediatr Int.
2019.

19) Kitagawa K, Nakaoka S, Asai Y, Watashi K, Iwami S.
A PDE multiscale model of hepatitis C virus13) Hu J, Lin YY, Chen PJ, Watashi K, Wakita T. Celland animal models for studying hepatitis B virus

infection can be transformed to a system of ODEs. J
Theor Biol 448: 80-85 (2018)

infection and drug development. Gastroenterology
156(2): 338-354 (2019)20) Kitamura K, Que L, Shimadu M, Koura M, Ishihara
Y, Wakae K, Nakamura T, Watashi K, Wakita T,14) Imagawa T, Sugiyama R, Shiota T, Li TC, Yoshizaki

Muramatsu M. Flap endonuclease 1 is involved in

S, Wakita T, Ishii K. Evaluation of Heating

cccDNA formation in the hepatitis B virus. PLoS

Conditions for Inactivation of Hepatitis E Virus

Pathog 14(6): e1007124 (2018)

Genotypes 3 and 4. J Food Prot. 81:947-952 (2018)21) Li TC, Bai H, Yoshizaki S, Ami Y, Suzaki Y, Doan15) Iwamoto M, Saso W, Sugiyama R, Ishii K, Ohki M,

YH, Takahashi K, Mishiro S, Takeda N, Wakita T.

Nagamori S, Suzuki R, Aizaki H, Ryo A, Yun JH,

Genotype 5 Hepatitis E Virus Produced by a Reverse

Park SY, Ohtani N, Muramatsu M, Iwami S, Tanaka

Genetics System Has the Potential for Zoonotic

Y, Sureau C, Wakita T, Watashi K. Epidermal

Infection. Hepatology Communications. 1: 160–172.

growth factor receptor is a host entry cofactor(2019)

triggering hepatitis B virus internalization. Proc Natl
Acad Sci USA 116(17): 8487-8492 (2019)22) Matsuda M, Yamanaka A, Yato K, Yoshii K,
Watashi K, Aizaki H, Konishi E, Takasaki T, Kato T,Muramatsu

M,

WakitaT,

SuzukiR.

28) Ohashi H, Nishioka K, Nakajima S, Kim S, Suzuki R,

High-throughput neutralization assay for multiple

Aizaki H, Fukasawa M, Kamisuki S, Sugawara F,

flaviviruses based on single-round infectious

Ohtani N, Muramatsu M, Wakita T and Watashi K.

particles using dengue virus type 1 reporter replicon.

The aryl hydrocarbon receptor–cytochrome P450

Sci Rep. Nov 9;8(1):16624 (2018).

1A1 pathway controls lipid accumulation andenhances the permissiveness for hepatitis C virus23) Momose H, Matsuoka S, Murayama A, Yamada N,
Okuma K, Ikebe E, Hoshi Y, Muramatsu M, Wakita

assembly. J Biol Chem. 293(51): 19559-19571.
(2018)T, Toyota K, Kato T, Hamaguchi I. Evaluation of invitro screening and diagnostic kits for hepatitis C
virus infection. J Clin Virol. 105: 97-102 (2018).

29) Oka T, Iritani N, Yamamoto SP, Mori K, Ogawa T,
Tatusmi C, Shibata S, Harada S, Wu FT. Broadly
reactive real-time reverse transcription-polymerase24) Murayama A, Fujiwara K, Yamada N, Shiina M, Aly

chain reaction assay for the detection of human

HH, Masaki T, Muramatsu M, Wakita T, Kato T.

sapovirus genotypes. J Med Virol. 91(3):370-377,

Evaluation of antiviral effects of novel NS5A

2019.

inhibitors in hepatitis C virus cell culture systemwith full-genome infectious clones. Antivir Res.
158: 161–170 (2018).

30) Okumura A, Mori H, Fee Chong P, Kira R, Torisu H,
Yasumoto S, Shimizu H, Fujimoto T, Tanaka-Taya K.
Acute Flaccid Myelitis Collaborative Study I. Serial25) Murayama A, Saitoh H, Takeuchi A, Yamada N,

MRI findings of acute flaccid myelitis during an

Matsumura T, Shiina M, Muramatsu M, Wakita T,

outbreak of enterovirus D68 infection in Japan. Brain

Kato T. Vitamin D derivatives inhibit hepatitis C& Development 2019virus production through the suppression of
apolipoprotein. Antivir Res. Dec;160:55-63 (2018).

31) Passioura T, Watashi K, Fukano K, Shimura S, Saso
W, Morishita R, Ogasawara Y, Tanaka Y, Mizokami26) Naito Y, Hamada-Tsutsumi S, Yamamoto Y,

M, Sureau C, Suga H, Wakita T. De Novo

Yoshioka Y, Watashi K, Ochiya T, Tanaka Y.

Macrocyclic Peptide Inhibitors of Hepatitis B Virus

Screening of microRNAs for a repressor of hepatitis

Cellular Entry. Cell Chem Biol 25(7): 906-915

B virus replication. Oncotarget 9(52): 29857-29868(2018)(2018)
32) Saso W, Tsukuda S, Ohashi H, Fukano K, Morishita27) Nio Y, Akahori Y, Okamura H, Watashi K, Wakita T,

R, Matsunaga S, Ohki M, Ryo A, Park SY, Suzuki R,

Hijikata M. Inhibitory effect of fasiglifam on

Aizaki H, Muramatsu M, Sureau C, Wakita T,

hepatitis B virus infections through suppression of

Matano T, Watashi K. A new strategy to identify

the sodium taurocholate cotransporting polypeptide.

hepatitis B virus entry inhibitors by AlphaScreen

Biochem Biophys Res Commun 501: 820-825

technology

targetingthe(2018)

interaction.

Biochem

Biophys501(2):374-379 (2018)

envelope-receptor
Res

Commun.

33) Sato H, Tanaka-Taya K, Shimizu H, Goto A, Tanaka S,38) Takeuchi F, Ikeda S, Tsukamoto Y, Iwasawa Y,

Nakano T, Hotta C, Okazaki T, Itamochi M, Ito M,

Qihao C, Otakaki Y, Ryota O, Yao WL, Narita R,

Okamoto-Nakagawa R, Yamashita Y, Arai S, Okuno

Makoto H, Watashi K, Wakita T, Takeuchi K,

H, Morino S, Oishi K. Polio vaccination coverage andChayama K, Kogure A, Kato H, Fujita T. Screening

seroprevalence of poliovirus antibodies after thefor inhibitor of episomal DNA identified dicumarol

introduction of inactivated poliovirus vaccines for

as a hepatitis B virus inhibitor. PLoS One 14(2):routinee0212233 (2019)

immunizationinJapan.

Vaccine37:

1964-1971, Mar 201939) Thongprachum A, Fujimoto T, Takanashi S, Saito H,
34) Shiromoto F, Aly HH, Kudo H, Watashi K,

Okitsu S, Shimizu H, Khamrin P, Maneekarn N,

Murayama A, Watanabe N, Zheng X, Kato T,

Hayakawa S, Ushijima H. Detection of nineteen

Chayamaenteric viruses in raw sewage in Japan. Infect GenetK,

Muramatsu

M,

WakitaT.

IL-1b/ATF3-mediated induction of Ski2 expression

Evol. 63: 17-23, 2018enhances hepatitis B virus x mRNA degradation.
Biochem Biophys Res Commun 503(3): 1854-1860(2018)

40) Tsukamoto Y, Ikeda S, Uwai K, Taguchi R, Chayama
K, Sakaguchi T, Narita R, Yao WL, Takeuchi F,
Otakaki Y, Watashi K, Wakita T, Kato H, Fujita T.

35) Suzuki Y, Doan YH, Kimura H, Shinomiya H,

Rosmarinic acid is a novel inhibitor for Hepatitis B

Shirabe K, Sakon and Katayama K. Predicting

virus

replication

targetingviralepsilondirections of changes in genotype proportions

RNA-polymerase interaction. PLoS One 13(5):between norovirus seasons in Japan. Front Microbiol.

e0197664 (2018)201941) Ueno M, Nogawa M, Siddiqui R, Watashi K, Wakita
36) Takahashi S, Metcalf CJE, Arima Y, Fujimoto T,

T, Kato N, Ikeda M, Okimura T, Isaka S, Oda T,

Shimizu H, Rogier van Doorn H, Le Van T, Chan YF,

Ariumi Y. Acidic polysaccharides isolated from

Farrar JJ, Oishi K Grenfell BT. Epidemic dynamics,

marine algae inhibit the early step of viral infection.

interactions and predictability of enteroviruses

Int J Biol Macromol 124: 282-290 (2018)

associated with hand, foot and mouth disease inJapan. Journal of the Royal Society, Interface
152018. 201842) Utsumi T, Wahyuni RM, Doan YH, Dinana Z,
Soegijanto S, Fujii Y, Juniastuti, Yamani LN, Matsui
C, Deng L, Abe T, Soetjipto, Lusida MI, Ishii K,37) Takeuchi M, Fukushima W, Nakano T, Inui M, Ohfuji

Shimizu H, Katayama K, Shoji I. Equine-like G3

S, Kase T, Ito K, Kondo K, Maeda A, Shimizu H,

rotavirus strains as predominant strains among

Hirota Y. Nationwide Survey on Pediatric Inpatientschildren in Indonesia in 2015-2016. Infect Genetof Hand, Foot and Mouth Disease, Herpangina, andEvol. 61:224-228, 2018.

Associated Complications during Epidemic Period inJapan: Estimated Number of Patients and Factors
Associated with Severe Cases. J Epidemiol 201843) Wakae K, Nishiyama T, Kondo S, Izuka T, Que L,
Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z,

Ahasan MM, Nakamura M, Fujiwara H, Yoshizaki T,
Hosomochi K, Tajima A, Nakahara T, Kiyono T,
Muramatsu M. Keratinocyte differentiation induces
APOBEC3A,

3B,

and

mitochondrialDNA

hypermutation Sci Rep. 2018 Jun 27;8(1):9745. doi:
10.1038/s41598-018-27930-z

44) Wang B, Ogata H, Takishima Y, Miyamoto S, Inoue
H, Kuroda M, Yamada K, Hijikata Y, Murahashi M,
Shimizu H, Okazaki T, Nakanishi Y Tani K. A Novel
Combination

Therapy

Oxaliplatin-resistantColorectal

for

Human

CancerUsing

Oxaliplatin and Coxsackievirus A11. Anticancer
Research 38: 6121-6126, 201845) Yasuura M, Shirato H, Higo-Moriguchi K, Fujimaki
M. Detection of norovirus-like particles with an
external

force-assisted

near-field

illuminationbiosensor. Japanese Journal of Applied Physics, 58,
071005-1-071005-5, 2019. 25)

46) Yamane D, Feng H, Rivera-Serrano EE, Selitsky SR,
Hirai-Yuki A, Das A, McKnight KL, Misumi I,
Hensley L, Lovell W, Gonzalez-Lopez O, Suzuki R,
Matsuda M, Nakanishi H, Ohto-Nakanishi T, Hishiki
T, Wauthier E, Oikawa T, Morita K, Reid LM,
Sethupathy P, Kohara M, Whitmire JK, Lemon SM.
Basal expression of interferon regulatory factor 1
drives intrinsic hepatocyte resistance to multiple
RNA viruses. Nature Microbiology. 7:1096-1104.
(2019)

47) Yang F, Duan S, Guo Y, Li Y, Yoshizaki S, Takeda N,
Wakita T, Muramatsu M, Zhao Y, He Z, Li TC.
Current status of hepatitis E virus infection at a rhesus
monkey farm in China. Vet Microbiol. 230:244-248.
(2019)