Fenestra™ Publications
1. Lou et al. Notch3 as a novel therapeutic target in metastatic medullary thyroid cancer. Surgery.
2018 Jan;163(1):104-111.
2. Ignat et al. Development of a methodology for in vivo follow-up of hepatocellular carcinoma inhepatocyte specific Trim24-null mice treated with myo-inositol trispyrophosphate. J Exp Clin
Cancer Res. 2016 Sep 29;35(1):155.
3. Yoo et al. SPECT/CT Imaging of High-Risk Atherosclerotic Plaques using Integrin-Binding RGD
Dimer Peptides. Sci Rep. 2015 Jun 30;5:11752.
4. Li et al. STK4 regulates TLR pathways and protects against chronic inflammation-related
hepatocellular carcinoma. J Clin Invest. 2015 Nov 2;125(11):4239-54.
5. Burk et al. Delayed contrast enhancement imaging of a murine model for ischemia reperfusion
with carbon nanotube micro-CT. PLoS One. 2015 Jan 30;10(1):e0115607.
6. Li et al. Pharmacokinetic Analysis of (64)Cu-ATSM Dynamic PET in Human Xenograft Tumors inMice. Diagnostics (Basel). 2015 Mar 27;5(2):96-112.
7. Hou et al. Noninvasive monitoring of mouse renal allograft rejection using micro-CT. Ann Surg
Treat Res. 2015 May;88(5):276-80.
8. Lasnon et al. Contrast-enhanced small-animal PET/CT in cancer research: strong improvement ofdiagnostic accuracy without significant alteration of quantitative accuracy and NEMA NU 4-2008
image quality parameters. EJNMMI Res. 2013 Jan 17;3(1):5.
9. Akladios et al. Structural imaging of the pancreas in rat using micro-CT: application to a noninvasive longitudinal evaluation of pancreatic ductal carcinoma monitoring. J Cancer Res Ther.
2013, 1(2): 70–76
10. Akladios et al. Contribution of microCT structural imaging to preclinical evaluation ofhepatocellular carcinoma chemotherapeutics on orthotopic graft in ACI rats. Bull Cancer. 2011Feb;98(2):120-32.
11. Lalwani et al. Contrast Agents for Quantitative MicroCT of Lung Tumors in Mice. ComparativeMedicine. 2013;63(6):482-490.
12. Sheikh et al. Micro-CT for characterization of murine CV disease models. JACC CardiovascImaging. 2010 Jul;3(7):783-5.
13. Dinkel et al. Intrinsic gating for small-animal computed tomography: a robust ECG-less paradigmfor deriving cardiac phase information and functional imaging. Circ Cardiovasc Imaging. 2008
Nov;1(3):235-43
14. Detombe et al. Longitudinal follow-up of cardiac structure and functional changes in an infarctmouse model using retrospectively gated micro-computed tomography. Invest Radiol. 2008
Jul;43(7):520-9.
15. Drangova et al. Fast retrospectively gated quantitative four-dimensional (4D) cardiac micro
computed tomography imaging of free-breathing mice. Invest Radiol. 2007 Feb;42(2):85-94.
16. Badea et al. Cardiac micro-computed tomography for morphological and functional phenotypingof muscle LIM protein null mice. Mol Imaging. 2007 Jul-Aug;6(4):261-8.
17. Nahrendorf et al. High Resolution Imaging of Murine Myocardial Infarction With Delayed
Enhancement Cine Micro-CT. Am J Physiol Heart Circ Physiol, 292(6): H3172-8, 2007.

MediLumine Inc.
5795 De Gaspe Avenue, Suite #112
Montreal (Quebec), Canada
H2S 2X3

medilumine.com
Tel: 514.360.1574
Toll free: 1.844.360.1574
Cell: 514.929.9744
Fax: 514.360.6014

18. Ford et al. Time-Course Characterization of the Computed Tomography Contrast Enhancementof an Iodinated Blood-Pool Contrast Agent in Mice Using a Volumetric Flat-Panel Equipped
Computed Tomography Scanner. Investigative Radiology. 41(4):384-390, 2006.
19. Badea et al. Imaging Methods for Morphological and Functional Phenotyping of the Rodent
Heart. Toxicologic Pathology. 34:111-117, 2006.
20. Badea et al. 4D Micro-CT of the Mouse Heart. Molecular Imaging. 4(2): 110-116, 2005.
21. Zhang et al. Comprehensive evaluation of the anti-angiogenic and anti-neoplastic effects ofEndostar on liver cancer through optical molecular imaging. PLoS One. 2014 Jan 8;9(1):e85559.
22. Zagorchev et al. Micro computed tomography for vascular exploration. J Angiogenes Res. 2010
Mar 5;2:7.
23. Lopez-Soler et al. Development of a Mouse Model for Evaluation of Small Diameter VascularGrafts. J Surgical Research, 139(1):1-6, 2007.
24. Gary et al. High Resolution X-ray Microscope. Applied Physics Letters, 90:181111-1-181111-3.
2007.
25. Goyal et al. Development of a model system for preliminary evaluation of tissue-engineered
vascular conduits. J Pediatric Surgery. 41:787-791. 2006.
26. Badea et al. Tumor imaging in small animals with a combined micro-CT/micro-DSA system using
iodinated conventional and blood pool contrast agents. Media Mol Imaging. 2006 JulAug;1(4):153-64.
27. Langheinrich et al. Quantitative Imaging of Microvascular Permeability in a Rat Model of
Lipopolysaccharide Induced Sepsis: Evaluation Using Cryostatic Microcomputed
Tomography. Investigative Radiology. 41(8):645-650, 2006.
28. Li et al. Visualization of experimental lung and bone metastases in live nude mice by X-ray
micro-computed tomography. Technol Cancer Res Treat. 2006 Apr;5(2):147-55.
29. Kindlmann et al. Practical vessel imaging by computed tomography in live transgenic mousemodels for human tumors. Mol Imaging. 2005 Oct-Dec;4(4):417-24.
30. Wang et al. MARS: a mouse atlas registration system based on a planar x-ray projector and anoptical camera. Phys Med Biol. 2012 Oct 7;57(19):6063-77.
31. Wang et al. Estimation of mouse organ locations through registration of a statistical mouse atlaswith micro-CT images. Epub 2011 Aug 18. IEEE Trans Med Imaging. 2012 Jan;31(1):88-102.
32. Zhang et al. An anatomical mouse model for multimodal molecular imaging. Conf Proc IEEE Eng
Med Biol Soc. 2009;2009:5817-20.
33. Liang et al. MicroPET/CT system for in vivo small animal imaging. Physics in Medicine andBiology. Physics in Medicine and Biology. 52:3881-3894, 2007.
34. Lasnon et al. Contrast-enhanced small-animal PET/CT in cancer research: strong improvement ofdiagnostic accuracy without significant alteration of quantitative accuracy and NEMA NU 4-2008
image quality parameters. EJNMMI Res. 2013 Jan 17;3(1):5.
35. Wall et al. Generation and characterization of anti-AA amyloid-specific monoclonal antibodies.
Front Immunol. 2011 Aug 8;2:32.
36. de Jong et al. FDG-PET, CT and MRI for the detection of experimental colorectal liver
metastases: An exploratory study. J Nucl Med. 2011; 52 (Supplement 1):312
37. Tsui et al. High-resolution small animal SPECT/CT imaging of atherosclerotic plaques in ApoE-/mice using Tc-99m Annexin-V and contrast enhanced CT. J Nucl Med. 2007; 48 (Supplement2):103P
38. Wall et al. Radioimaging of light chain amyloid with a fibril-reactive monoclonal antibody. J Nucl
Med. 2006 Dec;47(12):2016-24.

MediLumine Inc.
5795 De Gaspe Avenue, Suite #112
Montreal (Quebec), Canada
H2S 2X3

medilumine.com
Tel: 514.360.1574
Toll free: 1.844.360.1574
Cell: 514.929.9744
Fax: 514.360.6014

39. Avenell, J. Evaluating non-invasive microPET/CT imaging of K-562 myelosarcoma for monitoringtumor growth and angiogenesis in untreated and treated mice. J Nucl Med. 2006; 47(Supplement 1):556P
40. Isobe et al. Noninvasive Imaging of Atherosclerotic Lesions in Apolipoprotein E-Deficient andLow-Density-Lipoprotein Receptor –Deficient Mice with Annexin A5. J Nucl Medicine. 2006
47:1497-1505.
41. Wall et al. Quantiitative high-resolution microradiographic imaging of amyloid deposits in anovel murine model of AA amyloidosis. Amyloid: The Journal of Protein Folding Disorders.
12(3):149-156, 2005.
42. Martiniova et al. In vivo micro-CT imaging of liver lesions in small animal models. Methods 50(2010) 20–25
43. Kitahashi et al. Imaging study of pancreatic ductal adenocarcinomas in Syrian hamsters using Xray micro-computed tomography (CT). Cancer Sci. 2010 Jul;101(7):1761-6. Epub 2010 Apr 7.
44. Rampurwala et al. Visualization and quantification of intraperitoneal tumors by in vivo
computed tomography using negative contrast enhancement strategy in a mouse model ofovarian cancer. Transl Oncol. 2009 May;2(2):96-106.
45. Choukèr et al. Comparison of Fenestra VC Contrast-enhanced computed tomography imaging
with gadopentetate dimeglumine and ferucarbotran magnetic resonance imaging for the in vivo
evaluation of murine liver damage after ischemia and reperfusion. Invest Radiol. 2008Feb;43(2):77-91.
46. Graham et al. Noninvasive quantification of tumor volume in preclinical liver metastasis models
using contrast-enhanced x-ray computed tomography. Invest Radiol. 2008 Feb;43(2):92-9.
47. Martiniova L, Ohta S, Guion P, Schimel D, Lai EW, Klaunberg B, Jagoda E, Pacak K. Anatomicaland Functional Imaging of Tumors in Animal Models Focus on Pheochromocytoma. Ann. N.Y.
Acad. Sci., 1073:392-404, 2006.
48. Ohta et al. MicroCT for high-resolution imaging of ectopic pheochromocytoma tumors in theliver of nude mice. Int. J. Cancer, 119:2236-2241, 2006.
49. Ohta et al. Animal Models of Pheochromocytoma Including NIH Initial Experience. Ann. N.Y.
Acad. Sci. 1073:300-305, 2006.
50. Oldham et al. Three-dimensional imaging of xenograft tumors using optical computed andemission tomography. Medical Physics. 33(9):2193-3202, 2006.
51. Weber et al. Imaging of Murine Liver Tumor using MicroCT with a Hepatocyte-Selective Contrast
Agent: Accuracy Is Dependent on Adequate Contrast Enhancement. J Surg Research, 119(1):415, 2004.
52. Wisner et al. Percutaneous CT lymphography using a new polyiodinated biomimetic
microemulsion. Academic Radiology 9:S191-93, 2002.
53. Wisner ER, Weichert JP, Longino MA, Counsell RE, Weisbrode ST. A polyiodinated chylomicron
remnant-like emulsion for percutaneous CT lymphography: synthesis and preliminary findings.
Invest Radiol. 37(4):232-9, 2002.
54. Weichert JP, Lee FT Jr., Chosy, SG, Longino MA, Kuhlman JE, Heisey DM, Leverson GE. Combined
hepatocyte-selective and blood-pool contrast agents for the CT detection of experimental livertumors in rabbits. Radiology 216:865-871, 2000.
55. Desnoyers et al. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19
transgenic hepatocellular carcinoma models . Oncogene , (2008) Jan 3;27(1):85-97. Epub 2007
Jun 25.

MediLumine Inc.
5795 De Gaspe Avenue, Suite #112
Montreal (Quebec), Canada
H2S 2X3

medilumine.com
Tel: 514.360.1574
Toll free: 1.844.360.1574
Cell: 514.929.9744
Fax: 514.360.6014

56. Suckow et al. MicroCT liver contrast agent enhancement over time, dose, and mouse strain .
Mol Imaging Biol. 2008 Mar-Apr;10(2):114-20.
57. Price et al. A 3D Level Sets Method for Segmenting the Mouse Spleen and Follicles in VolumetricmicroCT Images. Proceedings of the 28th IEEE. New York City, New York. 2006.
58. Doerr-Stevens et al. Imaging Efficacy of a Hepatocyte-Selective Polyiodinated Triglyceride(DHOG-LE) for Contrast-enhanced CT . Acad. Radiol . 9 (Suppl. 1):S200-204, 2002.
59. Bakan et al. Hepatobiliary imaging using a novel hepatocyte-selective CT contrast agent . Acad.
Radiol . 9 (Suppl. 1):S194-199, 2002.
60. Bakan et al. Imaging Efficacy of a Hepatocyte-Selective Polyiodinated Triglyceride for Contrastenhanced Computed Tomography . Am. J. Therap . 8(5):359-365, 2001.
61. Bakan et al. Effects of physicochemical properties on biodistribution and imaging profiles .
Invest. Radiol . 35(3):158-169 2000.
62. Weichert et al. Lipid-Based blood pool CT imaging of the liver . Academic Radiol . 5:S16-19, 1998.
63. Lee et al. CT depiction of experimental liver tumors: Contrast enhancement with hepatocyteselective iodinated triglycerides versus conventional techniques . Radiology 203:465-470 1997.
64. Bakan et al. Physicochemical characterization of a synthetic lipid emulsion for hepatocyteselective delivery of lipophilic compounds: Application to polyiodinated triglycerides as contrast
agents for computed tomography. J. Pharm. Sci. 85(9):908-914, 1996.
65. Lee et al. Iodinated triglyceride-enhanced three-dimensional biliary imaging with helicalcomputed tomography scanning in dogs. Acad Radiol . 3:S449-S451, 1996.
66. Longino et al. Formulation of polyiodinated triglyceride analogues in a chylomicron remnantlike liver-selective delivery vehicle . Pharm Res . 13(6):875-879, 1996.
67. Weichert et al. Polyiodinated triglyceride analogs as potential computed tomography imaging
agents for the liver . J Med Chem . 1995 Feb 17;38(4):636-46.
68. Weichert et al. Targeted polyiodinated triglycerides for hepatic computed tomography . Invest
Radiol. 29(S2):S284-S285, 1994.
69. Weichert et al. Potential Tumor or Organ Imaging Agents. 27. Polyiodinated 1,3-di- and 1,2,3trisubstituted Triacylglycerols . J Med Chem , 29:2457-2465, 1986.
70. Weichert et al. Computed Tomography Scanning of Morris Hepatoma with Liver-Specific
Polyiodinated Triglycerides. Acad. Radiol. 3:412-417, 1996.
71. Weichert et al. Computed tomography scanning of hepatic tumors with polyiodinatedtriglycerides. Acad. Radiol. Aug;3 Suppl 2:S229-31.
72. Vandeghinste B, Trachet B, Renard M, Casteleyn C, Staelens S, Loeys B, Segers P, Vandenberghe
S. Replacing vascular corrosion casting by in vivo micro-CT imaging for building 3D
cardiovascular models in mice. Mol Imaging Biol. 2011 Feb;13(1):78-86.

MediLumine Inc.
5795 De Gaspe Avenue, Suite #112
Montreal (Quebec), Canada
H2S 2X3

medilumine.com
Tel: 514.360.1574
Toll free: 1.844.360.1574
Cell: 514.929.9744
Fax: 514.360.6014