13 Children’s Way ● Little Rock, Arkansas 72202
Postdoctoral Position in Fungal Pathogenesis and Drug Resistance Mechanisms
Arkansas Children’s Research Institute (ACRI)
University of Arkansas for Medical Sciences (UAMS)

Arkansas Children’s Research Institute (UAMS) seeks highly motivated and enthusiastic
Postdoctoral researcher to pursue advanced research and translational work in the fieldof fungal genetics and biology with a focus on Aspergillus fumigatus virulence,
identification of drug targets, and drug resistance pathways.
Qualifications
Prospective candidate should have a Ph.D. in the field of microbiology and genetics, orclosely related field; demonstrated expertise with molecular genetics and/or molecularbiology; demonstrated abilities with techniques including DNA cloning, DNA and RNA
extractions, RT-PCR, protein purification, heterologous gene expression, transformation,and gene knockout techniques in fungi; mouse models; and excellent written and oral
communication skills.
In depth knowledge in using standard genomics/molecular biology databases andsoftware tools to analyze and interpret large genomic and proteomic data sets will beadvantageous and preferred. Any experience in leading and training PhD students or
research assistants will be preferable.
Job Description
The successful applicant will be responsible for identifying the function of genes
responsible for hyphal growth and virulence in Aspergillus fumigatus. Work will include
but is not limited to: 1) cloning and validating of candidate effector genes; 2) phenotyping
and genotyping of a collection of Aspergillus isolates; 3) fungal transformation and genedeletion/disruption utilizing conventional method and CRISPR-Cas9 system,
characterization of post-translation modifications in the effector proteins including
identification of active sites of the effectors using site directed mutagenesis; 4)identification of protein-protein interactions and protein localization; and 5) evaluating theinteractions of the effectors in causing disease using mouse model.
Responsibilities and duties will include experimental designing and work, data collection,interpretation and management, and presentations at scientific meetings and publishing.
This appointment is initially for one year and is renewable based on funding availability
and satisfactory performance of the candidate.
Applicants may send (1) their CV with bibliography, (2) a cover letter with a statement ofresearch interests and career goals to Praveen Juvvadi (prjuvvadi@uams.edu).
Please apply through the web site below:
https://uasys.wd5.myworkdayjobs.com/en-US/UAMS_All_Careers/details/Post-DoctoralFellow_R0022610?q=post%20doctoral

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