Aperio GT 450 1.1.0.5000 Patch Notice
Leica Biosystems is always looking for ways to further improve our customers’ experience using our products. Oursoftware patches often include new features, but also include improvements based on customer input and our own
internal testing. Please make sure to read below for the details of this patch so you can get the best out of yourproduct. Thank you for being a customer of Leica Biosystems.

New Features Included in This Patch
Case #Description

27839

SVS image data was updated to include information related to any scan warnings such as image
quality and barcode warnings. For information on this new image data, refer to “SVS Metadata(Image Description)” in the Aperio ScanScope Virtual Slide (SVS) Image Format Specification, MAN0466.

27906

Aperio GT 450 has been updated to give field personnel the tools to configure the scanner tobypass the SVS file conversion to write DICOM image files directly to a network folder.

27812

After three incorrect login attempts, the account of the user trying to log in is now locked. A newfeature in Aperio SAM allows an administrator to unlock a locked account. For details, see Aperio
GT 450 IT Manager and Lab Administrator Guide.

27822

SVS image data was updated to include new image tags to differentiate the Aperio GT 450 from theAperio GT 450 DX: ScannerType and SessionMode. For information on these tags, see the Aperio
ScanScope Virtual Slide (SVS) Image Format Specification, MAN-0466.

27813

Aperio SAM now presents a new dialog box that allows the user to extend the session before thesession time expires.

Aperio GT 450 1.1.0.5000 Patch Notice, Revision B© Leica Biosystems Imaging, Inc. 2022

1Aperio GT 450 1.1.0.5000 Patch Notice

Improvements Included in This Patch
The following improvements were added in this patch.

Case # Description

227843The Real Time Focus algorithm was enhanced to improve finding the best focus position.

27806

Multiple ICC profiles are now available to adjust for variations in the spectral response of the scanner
cameras; Aperio SAM now allows Leica personnel to configure a scanner to use a specific ICC profile.

27666

Auto Image QC was enhanced to increase sensitivity in marking out of focus images reducing false
positives.

27807

Barcode decoder performance was improved.

27418

The Tissue Finder algorithm was enhanced to improve tissue cropping when viewing dark tissue andcontrol line samples.

27841

Placing of the prescan point was updated to correct an issue that could result in a striping artifact.

27811

Compression logic was enhanced to correct a problem when the time zone was set to Saudi Arabia.

27805

Aperio services startup was changed to address startup failure due to conflict with customer IT domain
policies.

27808

Slide detect logic was updated to address an issue where slides within a rack were incorrectly identified
as tilted slides.

27832

A new scanner suite installer was created to address issues related to backward compatibility.

27810

A new firmware installer was released to support remote firmware updates.

27907

DICOM file format was updated to:•

Correct the macro/slide photo image which had an incorrect image type specification,
preventing the macro image from being displayed in the Sectra PACS properly.

•Image meta data was updated for the thumbnail image to reflect recent standards updates thatnow contain a thumbnail type.

•The unused Multi-Resolution Navigation module was removed from the thumbnail image toconform to updated standards.

•The attribute indicating how frames are arranged (Dimension Organization Type) wascorrected.

27428

The scanner operating system was updated to Ubuntu 20.04 LTS distribution with Linux kernel upgradedto 5.4 for improved security.

27835

The Controller was updated to detect and notify Aperio SAM of the following intrusions:•Log entries containing login information for compromised users are modified/deleted with anull-overwrite log cleaner.

•Excessive login authentication failures over a short period of time are detected by examining
Linux audit logs.

•Known rootkits/malware are detected as installed on the system by using rkhunter.

Aperio GT 450 1.1.0.5000 Patch Notice, Revision B© Leica Biosystems Imaging, Inc. 2022

Aperio GT 450 1.1.0.5000 Patch NoticeCase # Description
27837

The scanner operating system was hardened to increase security by using these techniques:•File system integrity checks for critical binaries and files•

GRUB Bootloader password required•More audit logging•

Additional firewall rules to cover IPV627849

A new installer was released to enable remote security vulnerability patch updates to the scanneroperating system.

27824

Device certificates are now used to authenticate Aperio GT 450 and Aperio SAM communication.

27814

The Aperio SAM operating system was updated to Windows Server 2019 for improved security.

27827

An Aperio SAM defect was corrected which allowed a user account to be active after that user wasdeleted.

27829

An Aperio SAM defect was corrected that allowed non-administrator users to perform administration
tasks.

Aperio GT 450 1.1.0.5000 Patch Notice, Revision B© Leica Biosystems Imaging, Inc. 2022

3Aperio GT 450 1.1.0.5000 Patch NoticePart Number/Revision: PN-0031, Revision B
Date: March 2022
This document applies to Aperio GT 450 Controller, Aperio GT 450 Console, and Aperio GT 450 SAM versions 1.1 andlater

Copyright Notice

Copyright © 2022 Leica Biosystems Imaging, Inc. All Rights Reserved. LEICA and the Leica logo are registered trademarksof Leica Microsystems IR GmbH. Aperio, GT, and GT 450 are trademarks of Leica Biosystems Imaging in the USA andoptionally in other countries. Other logos, product and/or company names might be trademarks of their respectiveowners.

This product is protected by registered patents. For a list of patents, contact Leica Biosystems.

User Resources

For the latest information on Leica Biosystems Aperio products and services, please visit
www.LeicaBiosystems.com/Aperio.

Contact Information – Leica Biosystems Imaging, Inc.

Headquarters
Leica Biosystems Imaging, Inc.
1360 Park Center Drive
Vista, CA 92081
USA
Tel: +1 (866)-478-4111 (toll free)Direct International Tel: +1 (760)539-1100

Customer Support

General Information

Contact your local support representativewith any query and service request.

US/Canada Tel: +1 (866) 478-4111 (toll free)Direct International Tel: +1 (760) 5399-1100

https://www.leicabiosystems.com/servicesupport/technical-support/

Email: ePathology@LeicaBiosystems.com

23GT450, 23GT450SAM

4Aperio GT 450 1.1.0.5000 Patch Notice, Revision B© Leica Biosystems Imaging, Inc. 2022

Aperio GT 450 1.1.0.5000 Patch Notice

Revision Record

Rev

IssuedSections Affected

Detail

BMarch 2022

AllCorrection to release version number.

A

March 2022

All

New document.

Cautions and Notes
Serious Incidents Reporting – Any serious incident that has occurred in relation to the Aperio GT 450 shall be reported tothe manufacturer and the competent authority of the member state in which the user and/or the patient is established.

 Specifications and Performance - For device specifications and performance characteristics, refer to the document
Aperio GT 450 Specifications.
Installation - Aperio GT 450 must be installed by a trained Leica Biosystems Technical Services representative.

Repair - Repairs may be done only by a trained Leica Biosystems Technical Services representative. After repairs aredone, ask the Leica Biosystems technician to perform operation checks to determine the product is in good operating
condition.

Accessories - For information on using Aperio GT 450 with third-party accessories such as a Laboratory Information
System (LIS) not provided by Leica Biosystems, contact your Leica Biosystems Technical Services representative.

Quality Control - For information on image quality checks, see the Aperio GT 450 User’s Guide.

Maintenance and Troubleshooting - For information on maintenance and troubleshooting, see the Aperio GT 450 User’sGuide.

 Cybersecurity - Be aware that workstations are susceptible to malware, viruses, data corruption, and privacy breaches.
Work with your IT administrators to protect workstations by following your institution’s password and security policies.
To protect workstations from malware intrusion, use caution when inserting USB drives and other removable devices.
Consider disabling USB ports that are not in use. If you plug in a USB drive or other removable device, you should scan thedevices with an anti-malware utility. For Aperio recommendations on protecting your workstations and servers, see thedocument Aperio GT 450 IT Manager and Lab Administrator Guide.
If a suspected Aperio GT 450 cybersecurity vulnerability or incident is detected, contact Leica Biosystems TechnicalServices for assistance.
Training - This manual is not a substitute for the detailed operator training provided by Leica Biosystems or for otheradvanced instruction.

Safety - Safety protection may be impaired if this device is used in a manner not specified by the manufacturer.
For additional information on this product, including intended use and symbols glossary, refer to the primary
instructions for use, Aperio GT 450 User’s Guide.

Aperio GT 450 1.1.0.5000 Patch Notice, Revision B© Leica Biosystems Imaging, Inc. 20225