CellAppendix:TERMS and CONDITIONS
2014.02.19

Mouse ES : AES0192 NAT1(+/-)ES(C1)The RECIPIENT belongs to a not-for-profit academic organization (i.e. a university or another institution of higher
education or any nonprofit scientific or educational organization, including government agencies).
(2) The RECIPIENT recognizes and acknowledges that KYOTO UNIVERSITY retains the ownership ofBIOLOGICAL RESOURCE (hereinafter referred as the “ORIGINAL CELL”) and any cell reproduced orpropagated directly or indirectly from the ORIGINAL CELL regardless of maintaining identity with theORIGINAL CELL (hereinafter referred as the “CELL”).
(1)(3) The RECIPIENT acknowledges that ORIGINAL CELL has been created through the use of RF8 Mouse Embryonic Stem Cell
owned by The J. David Gladstone Institute.

The RECIPIENT agrees that the ORIGINAL CELL, CELL and any cell differentiated from the ORIGINAL CELL
or CELL, or any cell obtained in the course of differentiation from the ORIGINAL CELL or CELL :(a) will not be used to create admixed embryos with embryos of animals including human; and(b) will not be used in human subjects for any purpose.
(5) The RECIPIENT shall not use the ORIGINAL CELL and CELL for any purpose other than the academic research
purpose of conducting the research set forth in the MATERIAL TRANSFER AGREEMENT (hereinafter referredas “RESEARCH PROJECT”).
(4)(6) The RECIPIENT shall receive the prior written approval from KYOTO UNIVERSITY, if the RECIPIENT uses the ORIGINAL CELL
and CELL with anyone else outside of the RECIPIENT’S laboratory to carry out the RESEARCH PROJECT.

The ORIGINAL CELL and CELL shall be used only by the RECIPIENT and others working underRECIPIENT’S direct supervision at the RECIPIENT laboratory, and shall not be used by, as well as shall not be
distributed and assigned to anyone else either at the RECIPIENT organization or outside the organization.
(8) At the time of publication of the result from using the ORIGINAL CELL and/or CELL in the RESEARCH
PROJECT, whether in print or in electronic form, the RECIPIENT shall provide a copy of each publication toKYOTO UNIVERSITY.
iPS Cells Team
Center for iPS Cell Research and Application (CiRA),
Kyoto University
E-mail: cira-keiyaku@cira.kyoto-u.ac.jp
FAX: 81-75-366-7180
URL: http://www.cira.kyoto-u.ac.jp/e/index.html(9) The RECIPIENT agrees to grant to KYOTO UNIVERSITY royalty-free licenses, which are acquired byits use of the ORIGINAL CELL and CELL, for teaching and academic research purposes, and will not
exercise their intellectual property rights to KYOTO UNIVERSITY.
(10) The RECIPIENT agrees that KYOTO UNIVERSITY makes no representations and extends nowarranties of any kind, either expressed or implied. There are no express or implied warranties ofmerchantability or fitness for a particular purpose, or that the use of the ORIGINAL CELL, CELL andany cell derived from the ORIGINAL CELL will not infringe any patent, copyright, trademark, or otherproprietary rights. The RECIPIENT assumes all liability for damages which may arise from its use,
storage or disposal of the ORIGINAL CELL, CELL and any cell derived from the ORIGINAL CELL.
KYOTO UNIVERSITY will not be liable to the RECIPIENT for any loss, claim or demand made by theRECIPIENT, or claim or demand by any other party made against the RECIPIENT, due to or arisingfrom the use of the ORIGINAL CELL, CELL and any cell derived from the ORIGINAL CELL by theRECIPIENT.
(11) The RECIPIENT shall cite the paper specified below in any publication of the result from theRESEARCH PROJECT.
Yamanaka, S. et al. Essential role of NAT1/p97/DAP5 in embryonic differentiation and retinoic acid
pathway. EMBO 19: 5533-5541, 2000
(7)

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Cell TERMS and CONDITIONS
2014.02.19(12) The RECIPIENT acknowledges that the ORIGINAL CELL was created through introduction oftransgenes and that any experiments with implantation or inoculation of the ORIGINAL CELL intoliving organisms will be deemed recombinant DNA experiment. The RECIPIENT agree to comply withall laws, rules and regulations applicable to perform recombinant DNA experiment and secure necessary
approval before conducting such experiments.
(13) The RECIPIENT agrees that RIKEN informs to KYOTO UNIVERSITY of the RECIPIENT name, theRECIPIENT institution, the title of the RESEARCH PROJECT and the date of distribution.

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