Contai n ct uform s fo
at r mion oreSample preparation
for XRF analysis ofpharmaceuticals

Sample preparation of solid pharmaceuticals including
powders, tablets, capsules and other forms involve
grinding. Considering that only small amounts of sample
may be available, traditional preparation as pressedpellets is not always possible.
The preparation of capsules involves additional steps
as both the capsule and the drug in it require different
preparation methods. Note that you can easily prepare
liquid pharmaceuticals and pastes using generic sample
preparation for liquids.

Loose powder cups
When larger amounts of sample are available, you canuse traditional liquid cups for the analysis of loose
powders. This is a quick and practical solution when
the sample must be recovered or when accuracy andreproducibility are not the main drivers.

Small mass holder
When only very small amounts of sample are available,
you can use Malvern Panalytical’s patented small mass
holder. This sample holder is easy to use and it requires
minimal sample amounts ~ 100 mg.

www.malvernpanalytical.comCrushing
You may have to reduce the size of your sample to allow
for further processing, such as representative subsampling, homogenization and grinding. Crushing of thematerial is then required.

Grinding
Grinding of the material into a fine powder is required tominimize undesired particle size effects and allow further
processing like pressing or fusion.

Pressing
Pressed powders are often used in production control
environments, especially if the calibration ranges arenarrow.
Pellets can be pressed freely into Al cups or steel rings.
The use of binders is usually required to achieve thenecessary mechanical stability and robustness. Notethat the ultra-wax binder is used for the preparation ofhigh-quality pellets for the most demanding applications.
It can be found on Malvern Panalytical’s eStore.

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With over 2200 employees, we serve the world,
and we are part of Spectris plc, the worldleading precision measurements group.

Our worldwide team of specialists adds value to yourbusiness processes by ensuring applications expertise,
rapid response and maximum instrument uptime.
• Local and remote support• Full and flexible range of support agreements• Compliance and validation support• Onsite or classroom-based training courses• e-Learning training courses and web seminars• Sample and application consultancy

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Disclaimer: Although diligent care has been used to ensure that the information in this material is accurate, nothing herein can be construed to imply any representation or warranty as to the accuracy, correctness or completenessof this information and we shall not be liable for errors contained herein or for damages in connection with the use of this material. Malvern Panalytical reserves the right to change the content in this material at any time without notice.
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