CellAppendix:TERMS and CONDITIONS
2016.07.12

Human iPS: HPS0328 606A1

The RECIPIENT belongs to a not-for-profit academic organization (i.e. a university or another institution ofhigher education or any nonprofit scientific or educational organization, including government agencies).
(2) The RECIPIENT recognizes and acknowledges that KYOTO UNIVERSITY retains the ownership ofBIOLOGICAL RESOURCE (hereinafter referred as the “ORIGINAL CELL” and any cell reproduced orpropagated directly or indirectly from the ORIGINAL CELL regardless of maintaining identity with theORIGINAL CELL (hereinafter referred as the “CELL”).
(3) The RECIPIENT agrees that the ORIGINAL CELL, CELL and any cell differentiated from theORIGINALCELL or CELL, or any cell obtained in the course of differentiation from the ORIGINAL CELL orCELL:a) will not be used to create human embryos;b) will not be used to create human admixed embryos with embryos of animals including human;c) will not be used to induce differentiation to germ cells; andd) will not be used in human subjects for any purpose.
e) will not be used for the epidemiological study such as the genome sequencing analysis.
(4) The RECIPIENT shall not use the ORIGINAL CELL and CELL for any purpose other than academic research
purpose of conducting the research set forth in the MATERIAL TRANSFER AGREEMENT (hereinafter referredas “RESEARCH PROJECT”).
(5) The RECIPIENT shall receive the prior written approval from KYOTO UNIVERSITY, if the RECIPIENT uses
the ORIGINAL CELL or CELL with anyone else outside of the RECIPIENT’s laboratory to carry out theRESEARCH PROJECT.
(6) The RECIPIENT shall receive the prior written approval from KYOTO UNIVERSITY, if the RECIPIENT uses
the ORIGINAL CELL, CELL and/or cells differentiated from the ORIGINAL CELL or CELL for commercial
purposes including conducting collaborative research or contract research with for-profit organization(s).
(7) The ORIGINAL CELL and CELL shall be used only by the RECIPIENT and others working under
RECIPIENT’s direct supervision at the RECIPIENT laboratory, and shall not used by, nor shall not be distributed
nor assigned to anyone else either at the RECIPIENT organization or outside the organization.
(8) At the time of publication of the result from using the ORIGINAL CELL and/or CELL in the RESEARCH
PROJECT, whether in print or in electronic form, the RECIPIENT shall provide a copy of each publication toKYOTO UNIVERSITY.
Legal Affairs & IP
Center for iPS Cell Research and Application (CiRA), Kyoto University
E-mail: cira-keiyaku@cira.kyoto-u.ac.jp
FAX: 81-75-366-7023
URL: http://www.cira.kyoto-u.ac.jp/e/index.html(9) The RECIPIENT acknowledges that this Agreement is not the agreement to license the intellectual property rights
relating the ORIGINAL CELL and CELL owned by KYOTO UNIVERSITY to the RECIPIENT. TheRECIPIENT also acknowledges that no express or implied licenses or other rights are provided to theRECIPIENT from KYOTO UNIVERSITY to use the ORIGINAL CELL, CELL, or any related patents ofKYOTO UNIVERSITY for commercial purposes.
(10) The RECIPIENT agrees to grant to KYOTO UNIVERSITY royalty-free licenses, which are acquired by its use ofthe ORIGINAL CELL and CELL, for teaching and academic research purposes, and will not exercise theirintellectual property rights to KYOTO UNIVERSITY.
(11) The RECIPIENT agrees that KYOTO UNIVERSITY makes no representations and extends no warranties of anykind, either expressed or implied. There are no express or implied warranties of merchantability or fitness for aparticular purpose, or that the use of the ORIGINAL CELL, CELL and any cell derived from the ORIGINALCELL will not infringe any patent, copyright, trademark, or other proprietary rights. The RECIPIENT assumes all
liability for damages which may arise from its use, storage or disposal of the ORIGINAL CELL, CELL and any(1)Cell TERMS and CONDITIONS
2016.07.12
cell derived from the ORIGINAL CELL. KYOTO UNIVERSITY will not be liable to the RECIPIENT for anyloss, claim or demand made by the RECIPIENT, or claim or demand by any other party made against theRECIPIENT, due to or arising from the use of the ORIGINAL CELL, CELL and any cell derived from theORIGINAL CELL by the RECIPIENT.
(12) The RECIPIENT shall cite the paper specified below in any publication of the result from the RESEARCH
PROJECT.
An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood andPeripheral Blood Cells. (Stem Cells. 2012 Nov 29. doi: 10.1002/stem.1293.)(13) The RECIPIENT acknowledges that the ORIGINAL CELL was created through introduction of transgenes andthat any experiments with implantation or inoculation of the ORIGINAL CELL into living organisms will bedeemed recombinant DNA experiment. The RECIPIENT agree to comply with all laws, rules and regulations
applicable to perform recombinant DNA experiment and secure necessary approval before conducting suchexperiments.
(14) The RECIPIENT agrees that RIKEN informs to KYOTO UNIVERSITY of the RECIPIENT name, theRECIPIENT institution, the title of the RESEARCH PROJECT and the date of distribution.