International Congress on Biogenic Amines:
Biological and Clinical Perspectives
Program[Wednesday, October 17, 2007]
Opening Lectures
Chairpersons: U. Bachrach (Israel) , E. Agostinelli (Italy)
K. Igarashi (University of Chiba, Japan):Levels of protein-conjugated acrolein, interleukin-6 and C-reactive protein
predict silent brain infarction with high probability.
C. W. Porter (Roswell Park Cancer Institute, Buffalo,USA) :Spermidine/spermine N1-acetyltransferase as a possible effector of fat
homeostasis.
L. Alhonen (University of Kuopio, Finland):Phenotypic characteristics associated with genetic alteration of polyamine
metabolism.

[ThursFriday, October 18, 2007]
Session 1: BIOLOGICAL ROLES OF POLYAMINES
Chairpersons: P. M. Woster (USA), J. Jänne (Finland)
M.H. Park (National Institutes of Health, USA):
Mutational analyses of human eIF5A-1:identification of amino acid residues
critical for hypusine modification and eIF5A activity.

M.H. Park (National Institutes of Health, USA):
Mutational analyses of human eIF5A-1:identification of amino acid residues
critical for hypusine modification and eIF5A activity.
S. Valentini (Sao Paulo State University, Brazil):eIF5A genetic interactions link translation and secretion in yeast.
J.Y. Wang (University of Maryland Baltimore, USA):
Polyamines and early primary response genes in gastrointestinal mucosal
repair after injury.
L.R. Johnson (University of Tennessee Memphis, USA):
Apoptosis of intestinal epithelial cells is regulated through a polyamine
binding site on Src.
U. Bachrach (Hebrew University, Israel):
Prevention of cancer by green tea: role of polyamines.
N. Bagni (University of Bologna, Italy):
Alteration of polyamine metabolism during kiwifruit
pollen germination due to bis (guanylhydrazones).
T. Oshima (Institute of Environmental Microbiology, Kyowa Kako Co.,Japan):
Polyamines in thermophiles.Apoptosis of intestinal epithelial cells is regulated
through a polyamine binding site on Src.
Session 2: TRANSPORT AND METABOLISM OF POLYAMINES
Chairpersons: J. P. Moulinoux ( France), T. Oshima (Japan)
A. E. Pegg (Pennsylvania State University, USA):

Spermine synthase and spermine: the neglected segment of polyamine
metabolism.
C. Kahana (Weizmann Institute of Science, Israel):
Structural insights into antizyme inhibitors; characterization of structuralfeatures that affect its cellular behaviour and function.
J.L.A. Mitchell (Northern Illinois University, USA):
Roles of antizyme and antizyme inhibitor in abnormal growth of human tumorcells.
R. Peñafiel (University of Murcia, Spain):
Influence of antizyme inhibitor 2 (AZIN2/ODCp) on polyamine uptake bymammalian cells.

[Friday, October 19, 2007]
Session 2 (2a part): TRANSPORT AND METABOLISM OF
POLYAMINES
Chairpersons: L. Alhonen (Finland), O. Heby (Sweden)
E. W. Gerner (University of Arizona, USA):
Enhancement of polyamine transport by an activated K-RAS oncogene inhuman colon tumor-derived cells.
Y.G. Assaraf (Weizmann Institute of Science, Israel):
Novel extracellular vesicles mediate an ABCG2-dependent anti-cancer drug
sequestration and multidrug resistance.
S.C. Minocha (University of New Hampshire, USA):

Global impact of genetic manipulation of cellular putrescine on thetranscriptome.
M. A. Phillips (Southwestern Medical Center, Dallas, USA):
Regulation of polyamine biosynthesis in trypanosome parasites.
C. J. Bacchi (Pace University, New York, USA):
Polyamine-based drug development for parasitic diseases caused by protozoa.
A. Kaiser (University of Bonn, Germany):
The guanylhydrazone CNI-1493, an inhibitor of cytokine release with
antimalarial activity.
F. Sanchez-Jimenez (University of Malaga, Spain):
Towards a more integrated view of the amine metabolism.

[Saturday, October 20, 2007]
Session 3: PATHOPHYSIOLOGICAL FUNCTIONS OF POLYAMINES:
CLINICAL ASPECTS
Chairpersons: K. Igarashi (Japan), E. W. Gerner (USA)F.L. Meyskens (University of California, Orange, USA)
Marked efficacy of difluoromethylornithine (DFMO) plus sulindac in reducing
recurrent colorectal adenomas in patients with prior adenomas: results of arandomized, placebo-controlled double-blind trial.
B. Cipolla (CH Privé Saint Grégoire, Rennes, France):
Prognostic value of erythrocyte polyamine determinationin renal cell carcinoma.

E. Agostinelli (Rome University “Sapienza”, Italy):
Polyamine enzymatic oxidation products and lysosomotropic compounds incancer therapy.
Session 4: POLYAMINES IN CELL GROWTH AND
DIFFERENTIATION
Chairpersons: C. W. Porter (USA), C. Kahana ( Israel)
J. Jänne ( University of Kuopio, Finland):Cellular functions of the polyamines as studied with optically activeα-methylated derivatives of spermidine and spermine.
A. J. Michael (Institute of Food Research, Norwich, UK):
Excess polyamines antagonise growth and elicit a broad oxidative stressresponse independently of the polyamine oxidase PAO1 in Arabidopsis cells.
Session 5: POLYAMINES AND DIET
Chairpersons: A. J. Michael (UK), J. L. A. Mitchell (USA)J. P. Moulinoux (University of Rennes 1, France):
Polyamine deficient diet to relieve pain.
A.K. Mattoo (Agricultural Research Center, Beltsville, USA):
Polyamines resuscitate metabolic memory and upregulate anabolism-related
genes in transgenic tomato fruit.
Session 6: POLYAMINES AND TRANSGLUTAMINASES
Chairpersons: A. Abbruzzese (Italy), M. H. Park (USA)M. Griffin (Aston University, UK):

Nitric oxide may be an important regulator of TG2 activity in the extracellularenvironment by mediating its dual role as matrix crosslinker and cell surface
adhesion protein.
D. Serafini-Fracassini (University of Bologna, Italy):
Transglutaminases and reproduction: possible roles of pollentransglutaminases in incompatibility phenomena.
R. Ientile (University of Messina, Italy):
Homocysteine-induced TG2 expression is associated with NF-κB pathway inneuroblastoma cells.
A. Campisi (University of Catania, Italy):
Bioenergetic function in brain kindled mouse. possible involvement of tissuetransglutaminase.
W. A. Fogel (University of Lodz, Poland):Feeding behaviour in rats with portocaval anastomosis.

[Sunday, October 21, 2007]
Session 7: POLYAMINES DERIVATIVES AND ANALOGUES AS
THERAPEUTIC AGENTS
Chairperson: M.A. Phillips (USA), I. S. Blagbrough (UK)
M.P.M. Marques (University of Coimbra, Portugal):
Rational design of polyamine-based anticancer agents: changing the ligand
and the metal centre.
D.A. Averill-Bates ( Université du Québec á Montreal, Canada):
Activation of signalling cascades by acrolein, a spermine-derived aldehyde.

F. Flamigni (University of Bologna, Italy):
Effect of N1,N11-diethylnorspermine on cell survival and susceptibility toapoptosis of human chondrocytes.
M. Caraglia (Naples University, Italy):
Bovine serum amine oxidase and spermine potentiate the inhibition of growth
induced by Docetaxel in human epidermoid cancer (KB) cells.
Chairperson:A. E. Pegg (USA), E. Agostinelli (Italy)

F. Raul (University of Strasbourg, France):
Potentiation of apple procyanidin-triggered apoptosis by the PAO inhibitor
MDL 72527 in human colon cancer-derived metastatic SW620 cells.
P. M. Woster (Wayne State University, Detroit, USA):
Development of polyamine-based analogues as potential therapeutic agents.
J. Satriano (University of California San Diego,USA):
Evaluating the antiproliferative effects of agmatine, a polyamine analog.
I. S. Blagbrough (University of Bath, UK):
Lipopolyamines for the efficient delivery of siRNA.