2007 GORDON RESEARCHCONFERENCE ON POLYAMINES
Program[SUNDAY June 17, 2007]
METABOLIC DIVERSITY OF POLYAMINE FUNCTION
Chair: Phil Coffino (UCSF)
Alan Fairlamb (University of Dundee):
Neglected diseases - from metabolome to medicines
Kazuei Igarashi (Chiba University):
A unifying model for the role of polyamines in bacterial cell growth, thepolyamine modulon[MONDAY June 18, 2007]
BIOSYNTHETIC PATHWAYS AND TRANSPORT
Chair: Patrick Woster and Senya Matsufuji
Miguel Angel Medina(University of Malaga):
Mathematical modeling of polyamine metabolism in mammals
Ted Sybertz (Genzyme):
Inhibitors of S-adenosylmethionine decarboxylase for the treatment of African
sleeping sickness
Sigrid Roberts (Oregon Health Sciences University):
Effects of ornithine decarboxylase knockouts on growth of Leishmania in vivo
Otto Phanstiel IV (University of Central Florida):
Synthesis and biological evaluation of dihydromotuporamine derivatives incells containing active polyamine transporters
Short TalksErin Willert (University of Texas Southwestern Med Center):Allosteric activation of trypanosomatid S-adenosylmethionine decarboxylaseby a catalytically dead homolog

Shridhar Bale (Cornell):
Structural insights into putrescine activation of human S-adenosylmethionine
decaroboxylase
CATABOLIC PATHWAYS
Chair: Heather Wallace (University of Aberdeen)
Steve Ealick (Cornell):
Structure MTA phosphorylase and MTA recycling
Kami Kim (Einstein):
MTA recycling in Plasmodium parasites
Maria Bewley (Penn State):
Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target
Short TalksShin Kurihara (Riken BRC-JCM):
A novel putrescine degradation pathway involves γ-glutamylated
intermediates in E. coli
[TUESDAY June 19, 2007]
SYSTEMS BIOLOGYChair: Keiko Kashiwagi (Chiba Institute of Science)
Oliver Fiehn (UC Davis):
Use of metabolomics to analyze metabolic perturbation
Tony Michael (Institute of Food Research, Norwich):
Transcriptomic analysis of the response of plant cells to changes in polyaminelevelsBenjamin Tu (UT Southwestern):
Logic of a yeast metabolic cycle
David Morris (University of Washington):
Applications of the polysome-associated transcriptome to systems biology
Selected from Graduate Research Symposium:Jeongmi Lee (UT Southwestern
Medical Center):
Evolution of substrate specificity in the type IV ornithine decarboxylase

family
Selected from Graduate Research Symposium: Paula L Feinberg-Zadek(Massachusetts Institute of Technology):
Polyamines facilitate a 'molecular switch' from LTD to LTP in the medial
nucleus tractus solitarius
Poster Session
POST-TRANSLATIONAL REGULATION
Chair: Myung Park (NIH)John Atkins (Cork and University of Utah):
Frameshifting in antizyme expression
Ursula Mangold (Harvard):
Antizyme inhibitor: modulator of cell proliferation
Kuang Yu Chen (Rutgers):
Partners and function of eukaryotic initiation factor 5A
Short TalksManas Chattopadhyay (NIH):
The function of spermidine in yeast[WEDNESDAY June 20, 2007]
SIGNALLING
Chair: Stina Oredsson (Lund University)
Susan Gilmour (Lankenau Institute for Medical Research):
Effects of polyamines on kinase cascades and relationship to tumor promotion
Lisa Shantz (Penn state):
Regulation of ODC synthesis in Ras-transformed intestinal epithelial cells
Keith Wilson (Vanderbilt University):
Helicobacter pylori-induced macrophage apoptosis requires activation ofornithine decarboxylase by c-Myc
Tomonobu Kusano (Tohoku University):
Evidence for a protective role of the polyamine spermine against
environmental stresses in Arabidopsis thaliana
Short TalksYoshihiko Ikeguchi (Josai University):Apoptosis signal - regulating kinase 1 affects polyamine contents and thesensitivity of mouse fibroblasts to polyamine analogs
Lan Xiao (University of Maryland):
Regulation of ATF-2 mRNA stability by RNA-binding protein HuR following
polyamine depletion in intestinal epithelial cells
Poster Session
BACTERIAL PATHOGENESIS
Chair: Anthony Pegg (Penn State)
Paul Williams (University of Nottingham):Look who's talking: cell-to-cell communication in the bacterial world
Phil Rather (Emory):
Role of amino acid decarboxylases in regulating swarming motility in Proteus
mirabilis
Matt Mulvey (University of Utah):Polyamine-mediated resistance of uropathogenic Escherichia coli tonitrosative stress
Short TalksWalid A. Houry (University of Toronto):
X-ray structure of the E. coli inducible lysine decarboxylase: implications forthe role of the bacterial stringent response during acid stress[THURSDAY June 21, 2007]
POLYAMINES IN MAMMALIAN PATHOGENESIS
Chair: Gene Gerner (University of Arizona)
Bob Casero (Johns Hopkins):
Histone modifying enzymes as new targets for polyamine analogues
Carl Porter (Roswell Park Cancer Institute):
Downstream consequences of SSAT-induced changes in metabolic fluxJuhani Janne (University of Kuopio):
Polyamine catabolism and the regulation of glucose and energy metabolism
Laurence Marton (Cellgate):
Clinical trials of polyamine analogs in cancer and macular degeneration

Short TalksSalim Merali (Temple School of Medicine):
Mechanism and tissue specificity of nicotine-mediated lungS-adenosylmethionine reduction and resistance to pneumocystis infection
Gene Gerner (University of Arizona):
Difluoromethylornithine plus sulindac for the prevention of sporadic
colorectal adenomas
Poster Session
KEYNOTE
Chair: Nigel Yarlett(Pace University)
Cy Bacchi (Pace University)
ODC and AdoMetDC inhibitors as therapy for African sleeping sickness[FRIDAY June 22, 2007]
Departure