2003 GORDON RESEARCHCONFERENCE ON POLYAMINES
Program★
Session 1: Metabolism/Regulation
Discussion Leader: Eugene W. Gerner (University of Arizona)
Anthony E. Pegg (Pennsylvania State University):
Overview of polyamine metabolism.
Emanuele Giordano (University of Bologna):
Coordinate biochemical cross-talk among arginine-dependent enzymatic
pathways in the hypertrophic heart.
Colin Hafrey (Institute of Food Research):
Polyamines and translation inhibition.
★

Session 2: Homeostasis I (Oxidases/Transport)
Discussion Leader: Heather M. Wallace (University of Aberdeen), John L. A.
Mitchell (Northern Illinois University)
Carl W. Porter (Roswell Park Cancer Institute):
New insights into polyamine catabolism based on SMO and PAO.
Robert A. Casero (John Hopkins University School of Medicine):
Polyamine catabolism, a matter of life and death.
Keiko Kashiwagi (Chiba Univerisity):
Polyamine transport in eukaryotic and prokaryotic cells.
Flavio Flamingi (University of Bologna):
Polyamine and signaling pathways in mammalian cells.
★

Session 3: Homeostasis II (Antizyme)
Discussion Leader: John Atkins (University of Utah)

Tongwen Wang (Virginia Mason Research Institute):
Antizyme-dependent degradation in BMP-mediated signaling pathways.
Senya Matsufuji (Jikei University School of Medicine):
An upstream element for the antizyme frameshift signal.
Philip Coffino (University of California, San Francisco):
ODC not busy being born is busy dying.
★

Session 4: Chromatin/Gene Activation
Discussion Leader: Olle Heby (Umea University)
Subhash Minocha (University of New Hampshire):
Regulation of gene expression in relation to polyamine metabolism.
Andrew Maniotis (University of Illinois at Chicago):
Unexpected differeneces among normal versus malignant cell DNA
sequestratinon or exposure:targeting oncogene deregulation with polyamines.
★

Session 5: Parasites
Discussion Leader: Nigel Yarlett (Pace University)
Sigrid Roberts (Oregon Health Sciences University):
Polyamines in Leishmania: elucidation of a pathway.
Margaret Phillips (University of Texas Southwestern Medical Center):(Protozoal polyamines: Cell organization and antioxidaive protection.)
Salim Merali (New York University School of Medicine):
S-adenosylmethionine, polyamines and Pneumocystis carini.
★

Session 6: Transgenics/Cancer
Discussion Leader: Lisa Shantz (Pennsylvania State University), Frank Berger(University of South Carolina)
Juhani Janne (University of Kuopio):Genetic engineering of polyamine catabolism in transgenic rats and mice.
John Cleveland (St. Jude Children's Research Hospital):
Regulation and role of ODC in MYC-induced tumorigenesis.
Debora Kramer (Roswell Park Cancer Institute):
Activated polyamine catabolism and cancer prevention.
Thomas O'Brien (Lankenau Medical Research Center):Anti-polyamine therapy of squamous cell carcinoma.
★

Session 7: Enzyme Structure
Discussion Leader: Margaret Phillips (University of Texas Southwestern
Medical Center)
Steve Ealick (Cornell University):
Structural studies on polyamine biosynthetic enzymes.
★

Session 8: New Leads/Clinical Aspects
Discussion Leader: Stina Oredsson, (University of Lund) Lawrence Marton(SLIL Biomedical)
Ben Frydman (SLIL Biomedical):Novel synthetic polyamine analogs which inhibit growth of cancer tumor
xenografts in nude mice.
Elena Martinez (University of Arizona):
Genetic variant in the ornithine decarboxylase gene and aspirin use suppress
polyamine levels
to reduce risk of colorectal neoplasia.
Victor Levin (M. D. Anderson Cancer Center):
Efficacy of DFMO with PVC in randomized phase III study of patients withanaplastic gliomas.
★

Session 9: Keynote AddressSeymour Cohen
Some views on the past and present status of polyamine research.