Shigenori Kumazawa @ Univ. of Shizuoka

CURRICULUM VITAE
Update: 2/26/2024

Shigenori KUMAZAWA, Ph.D.
-Position: Professor-Laboratory: Laboratory of Food Analytical Chemistry-University: Department of Food Science and Biotechnology
University of Shizuoka
52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan
Tel: +81-54-264-5523
Fax: +81-54-264-5523
E-mail: kumazawa (at) u-shizuoka-ken.ac.jp

Fields of Research Interest-Food Analytical Chemistry-Food Functional Science-Natural Products Chemistry

Education-Ph.D. Agriculture, Nagoya University, 1995
-M.A. Agricultural Chemistry, Nagoya University, 1988
-B.S. Agricultural Chemistry, Nagoya University, 1986

Experience-University of Shizuoka, Professor, 2010-University of Shizuoka, Associate Professor, 2004-2010-University of Shizuoka, Research Assistant Professor, 1997-2003-Research Scientist at Mitsubishi Chemical Cooperation, 1988-1997

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Shigenori Kumazawa @ Univ. of Shizuoka

Publications
Original papers (2010-)
1.

Toshiro Ohta, Eriko Ishizu-Nagashima, Sayaka Mizuno, Ryo Miyata, Boonyadist
Vongsak, Shigenori Kumazawa: Anti-angiogenic activity of mangostins isolated fromThailand stingless bee propolis. Nat. Prod. Commun., 2023, 18, 1-7.

2.

Sayaka Mizuno, Ryo Miyata, Agus Sukito, Muhamad Sahlan, Shigenori Kumazawa: A
new chromanone derivative from Calophyllum inophyllum resin and its antibacterialactivity. Rec. Nat. Prod., 2023, 17, 1085-1089.

3.

Wataru Kadowaki, Ryo Miyata, Sayaka Mizuno, Misa Fujinami, Yoshizumi Sato,Shigenori Kumazawa: Prenylated acetophenones from the roots of Calendula
officinalis and their anti-inflammatory activity. Biosci. Biotechnol. Biochem., 2023, 87,683-687.

4.

Sayaka Mizuno, Ryo Miyata, Muhamad Sahlan, Shigenori Kumazawa: Improvement ofwater solubility and antibacterial activity of Calophyllum inophyllum resin andcalophylloidic acid A via inclusion complexation with cyclodextrins. Food Sci.
Technol. Res., 2023, 29, 301-307.

5.

Aoi Yanagihara, Ryo Miyata, Taichi Mitsui, Hajime Sato, Shigenori Kumazawa: Two
new hydroxycinnamoyl acid amides isolated from Australian bee pollen using
molecular networking analysis. Phytochem. Lett., 2023, 54, 91-96.

6.

Wataru Kadowaki, Ryo Miyata, Misa Fujinami, Yoshizumi Sato, Shigenori Kumazawa:
Catechol-O-methyltransferase Inhibitors from Calendula officinalis Leaf. Molecules,2023, 28, 1333.

7.

Chie Watanabe, Ryo Miyata, Sachio Wakayama, Shigenori Kumazawa: New acylated
flavonoid isolated from Thai bee pollen using molecular networking analysis anddetermination of its catechol-O-methyltransferase inhibitory activity. Phytochem.
Lett., 2023, 53, 239-244.

8.

Wataru Kadowaki, Yuki Sugahara, Tomoyasu Toyoizumi, Teruko Nakajima, Shigenori
Kumazawa: Isolation and identification of antioxidant phenylpropanoids from the fruit
peel of Akebia trifoliata Koidz. Food Sci. Technol. Res., 2023, 29, 27-34.

9.

Ryo Miyata, Hitomi Sano, Sara Hoshino, Shigenori Kumazawa: Thermostability andcatechol-O-methyltransferase inhibitory activity of acylated anthocyanins from purpleyam. Biosci. Biotechnol. Biochem., 2022, 86, 916-921.

10. Ryo Miyata, Hitomi Sano, Shigenori Kumazawa: New acylated anthocyanin isolated
from purple yam using molecular networking analysis. Food Sci. Technol. Res., 2022,28, 329-334.
11. Kazuma Mukaide, Yuko Shimamura, Shuichi Masuda, Boonyadist Vongsak, ShigenoriKumazawa: Antibacterial and antibiofilm activities of Thailand propolis against
Escherichia coli. Nat. Prod. Commun., 2022, 17, 1-5.
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Shigenori Kumazawa @ Univ. of Shizuoka
12. Ryo Miyata, Sara Hoshino, Mok-Ryeon Ahn, Shigenori Kumazawa: Chemical profilesof Korean bee pollens and their catechol-O-methyltransferase inhibitory activities. J.
Agric. Food Chem., 2022, 70, 1174-1181.
13. Sayaka Mizuno, Ryo Miyata, Kazuma Mukaide, Sari Honda, Agus Sukito, MuhamadSahlan, Tohru Taniguchi, Shigenori Kumazawa: New compound from the plant originof propolis from Lombok, Indonesia and its antibacterial activity. Results Chem., 2022,100276.
14. Yuki Sugahara, Toshiro Ohta, Yoshiki Taguchi, Wataru Kadowaki, Sari Honda,Yasuhiro Kashima, Taiji Matsukawa, Shigenori Kumazawa: Resveratrol derivative
production by high-pressure treatment: proliferative inhibitory effects on cervicalcancer cells. Food Nutr. Res., 2022, 66, 7638.
15. Ryo Miyata, Tomoharu Motoyama, Shogo Nakano, Sohei Ito, Kazuma Mukaide,
Boonyadist Vongsak, Shigenori Kumazawa: Catechol-O-methyltransferase inhibitors
isolated from Thai propolis. Nat. Prod. Commun., 2021, 16, 1-5.
16. Kohsuke Shimomura, Hironari Kako, Hidehiko Yokogoshi, Mok-Ryeon Ahn, Shigenori
Kumazawa: Promotion effect of the propolis from Jeju Island, Korea, on NGF
secretion in human glioblastoma cells. J. Nat. Med., 2021, 75, 1030-1036.
17. Kazuma

Mukaide,Sari

Honda,

Boonyadist

Vongsak,

Shigenori

Kumazawa:

Prenylflavonoids from propolis collected in Chiang Mai, Thailand. Phytochem. Lett.,
2021, 43, 88-93.
18. Saori Inui, Takahiro Hosoya, Kazuma Yoshizumi, Hajime Sato, Shigenori Kumazawa:
Phytochemical and anti-inflammatory properties of Senegalese propolis and isolatedcompounds. Fitoterapia, 2021, 151, 104861.
19. Naoki Okamura, Toshiro Ohta, Kazuhiro Kunimasa, Yoshihiro Uto, Shigenori
Kumazawa: Antiangiogenic activity of flavonols in chorioallantoic membrane (CAM)
assay. Food Sci. Technol. Res., 2020, 26, 891-896.
20. Takuma Kurata, Naoki Misawa, Takahiro Hosoya, Tomoe Yamada-Kato, Isao Okunishi,
Shigenori Kumazawa: Isolation and identification of compounds from wasabi(Wasabia japonica Matsumura) flowers and investigation of their antioxidant andanti-inflammatory activities. Food Sci. Technol. Res., 2019, 25, 449-457.
21. Ryo Miyata, Muhamad Sahlan, Yoshinobu Ishikawa, Hiroshi Hashimoto, Sari Honda,Shigenori Kumazawa: Propolis components from stingless bees collected on South
Sulawesi, Indonesia, and their xanthine oxidase inhibitory activity. J. Nat. Prod., 2019,82, 205-210.
22. Eriko Ishizu, Sari Honda, Boonyadist Vongsak, Shigenori Kumazawa: Identification ofplant origin of propolis from Thailand stingless bees by comparative analysis. Nat.
Prod. Commun., 2018, 13, 973-975.
23. Naoki Misawa, Takahiro Hosoya, Shuhei Yoshida, Osamu Sugimoto, Tomoe
Yamada-Kato, Shigenori Kumazawa: 5-Hydroxyferulic acid methyl ester isolated fromwasabi leaves inhibits 3T3-L1 adipocyte differentiation. Phytother. Res., 2018, 32,3

Shigenori Kumazawa @ Univ. of Shizuoka
1304-1310.
24. Eriko Ishizu, Sari Honda, Boonyadist Vongsak, Shigenori Kumazawa: Identification ofplant origin of propolis from Thailand stingless bees by comparative analysis. Nat.
Prod. Commun., 2018, 13, 973-975.
25. Kazuki Yoshimura, Takahiro Hosoya, Misa Fujinami, Toshiro Ohta, Shigenori
Kumazawa: Nymphaeol-C, a prenylflavonoid from Macaranga tanarius, suppresses theexpression of fibroblast growth factor 18. Phytomedicine, 2017, 36, 238-242.
26. Koharu Okumura, Hiroo Matsui, Takahiro Hosoya, Shigenori Kumazawa: Effect ofharvest time in some in vitro functional properties of hop polyphenols. Food Chem.,
2017, 225, 69-76.
27. Koharu Okumura, Takahiro Hosoya, Kai Kawarazaki, Norihiko Izawa, Shigenori
Kumazawa: Antioxidant activity of phenolic compounds from fava bean sprouts. J.
Food Sci., 2016, 81, 1394-1398.
28. Chiemi Moriya, Takahiro Hosoya, Sayuri Agawa, Yasumasa Sugiyama, Ikuko Kozone,Kazuo Shin-ya, Norihiko Terahara, Shigenori Kumazawa: New acylated anthocyaninsfrom purple yam and their antioxidant activity. Biosci. Biotechnol. Biochem., 2015, 79,1484-1492.
29. Shuhei Yoshida, Takahiro Hosoya, Saori Inui, Hideki Masuda, Shigenori Kumazawa:
Component analysis of wasabi leaves and an evaluation of their anti-inflammatory
activity. Food Sci. Technol. Res., 2015, 21, 247-253.
30. Saori Inui, Ai Hatano, Megumi Yoshino, Takahiro Hosoya, Yuko Shimamura, Shuichi
Masuda, Mok-Ryeon Ahn, Shigemi Tazawa, Yoko Araki, Shigenori Kumazawa:
Identification of the phenolic compounds contributing to antibacterial activity inethanol extracts of Brazilian red propolis. Nat. Prod. Res. 2014, 28, 1293-1296.
31. Masato Nishizawa, Takahiro Hosoya, Takatsugu Hirokawa, Kazuo Shin-ya, Shigenori
Kumazawa: NMR spectroscopic characterization of inclusion complexes of theaflavindigallate and cyclodextrins. Food Sci. Technol. Res. 2014, 20, 663-669.
32. Makoto Kobayashi, Masato Nishizawa, Nao Inoue, Takahiro Hosoya, Masahito
Yoshida, Yuichi Ukawa, Yuko M Sagesaka, Takayuki Doi, Tsutomu Nakayama,Shigenori Kumazawa, Ikuo Ikeda: Epigallocatechin gallate decreases the micellar
solubility of cholesterol via specific interaction with phosphatidylcholine. J. Agric.
Food Chem., 2014, 62, 2881-2890.
33. Seon-II Park, Toshiro Ohta, Shigenori Kumazawa, Mira Jun, Mok-Ryeon Ahn: Korean
propolis suppresses angiogenesis through inhibition of tube formation and endothelial
cell proliferation. Nat. Prod. Commun. 2014, 9, 555-560.
34. Michiyo Kubota, Takahiro Hosoya, Syuichi Fukumoto, Tsuyoshi Miyagi, Shigenori
Kumazawa: Anti-melanogenic compounds in Rubus croceacanthus. J. Berry Res. 2014,
4, 127-135.
35. Saori Inui, Takahiro Hosoya, Shigenori Kumazawa: Hawaiian propolis: comparative
analysis and botanical origin. Nat. Prod. Commun. 2014, 9, 165-166.
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Shigenori Kumazawa @ Univ. of Shizuoka
36. Shigenori Kumazawa, Masayo Murase, Noboru Momose, Syuichi Fukumoto: Analysisof antioxidant prenylflavonoids in different parts of Macaranga tanarius, the plantorigin of Okinawan propolis. Asian Pac. J. Trop. Med. 2014, 7, 16-20.
37. Shigenori Kumazawa, Satomi Kubota, Haruna Yamamoto, Naoki Okamura, Yasumasa
Sugiyama, Hirokazu Kobayashi, Toshiro Ohta, Motoyasu Nakanishi: Antiangiogenic
activity of flavonoids from Melia azedarach. Nat. Prod. Commun. 2013, 8, 1719-1720.
38. Ikumi Tsuchiya, Takahiro Hosoya, Motoko Uchida, Kazuhiro Kunimasa, Toshiro Ohta,
Shigenori Kumazawa: Nymphaeol-A isolated from Okinawan propolis suppresses
angiogenesis and induces caspase-dependent apoptosis via inactivation of survival
signals. Evid. Based Complement. Alternat. Med., doi: 10. 1155/2013/826245. Epub2013 Apr 24.
39. Shigenori Kumazawa, Josep Serra Bonvehí, Cristina Torres, Ahn Mok-Ryeon,
Francisco José Orantes Bermejo: Chemical and functional characterization of propolis
collected from East Andalusia (Southern Spain). Phytochem. Anal. 2013, 24, 608-615.
40. Kohsuke

Shimomura, Yasumasa Sugiyama, Jun Nakamura, Mok-Ryeon

Ahn,

Shigenori Kumazawa: Component analysis of propolis collected on Jeju Island, Korea.
Phytochemistry 2013, 93, 222-229.
41. Saori Inui, Takahiro Hosoya, Yuko Shimamura, Shuichi Masuda, Takeshi Ogawa,Hirokazu Kobayashi, Kenichi Shirafuji, Reuben Toli Moli, Ikue Kozone, Kazuo
Shin-ya, Shigenori Kumazawa: Solophenols B-D and solomonin: new prenylated
polyphenols isolated from propolis collected from the Solomon Islands and theirantibacterial activity. J. Agric. Food Chem. 2012, 60, 11765-11770.
42. Michiyo Kubota, Chie Ishikawa, Yasumasa Sugiyama, Syuichi Fukumoto, Tsuyoshi
Miyagi, Shigenori Kumazawa: Anthocyanins from the fruits of Rubus Croceacanthus
and Rubus sieboldii, wild berry plants from Okinawa, Japan. J. Food Comp. Anal.
2012, 28, 179-182.
43. Kohsuke

Shimomura, Saori Inui, Yasumasa Sugiyama, Miho Kurosawa, Jun

Nakamura, Su-Jin Choi, Mok-Ryeon Ahn, Shigenori Kumazawa: Identification of theplant origin of propolis from Jeju Island, Korea, by the observation of honeybee
behavior and phytochemical analysis. Biosci. Biotechnol. Biochem. 2012, 76,2135-2138.
44. Shigenori Kumazawa, Yukiko Okuyama, Masayo Murase, Mok-Ryeon Ahn, JunNakamura, Tomoki Tatefuji: Antioxidant activity in honeys of various floral origins:Isolation and identification of antioxidants in peppermint honey. Food Sci. Technol.
Res. 2012, 18, 679-685.
45. Ai Hatano, Takashi Nonaka, Megumi Yoshino, Mok-Ryeon Ahn, Shigemi Tazawa,
Yoko Araki, Shigenori Kumazawa: Antioxidant activity and phenolic constituents ofred propolis from Shandong, China. Food Sci. Technol. Res. 2012, 18, 577-584.
46. Saori Inui, Yuko Shimamura, Shuichi Masuda, Kenichi Shirafuji, Reuben T. Moli,Shigenori Kumazawa: A new prenylflavonoid isolated from propolis collected in the5

Shigenori Kumazawa @ Univ. of Shizuoka
Solomon Island. Biosci. Biotechnol. Biochem. 2012, 76, 1038-1040.
47. Rie Ikeda, Masayoshi Yanagisawa, Nobuyuki Takahashi, Teruo Kawada, ShigenoriKumazawa, Noriyuki Yamaotsu, Izumi Nakagome, Shuichi Hirono, Takanori Tsuda:
Brazilian proporis-derivered components inhibit TNF-α-mediated downreguration ofadiponectin expression via different mechanisms in 3T3-L1 adipocytes. Biochim.
Biophys. Acta - General Subjects 2011, 1810, 695-703.
48. Sayuri Agawa,Hiroyuki

Sakakibara,ReiIwata,

KayokoShimoi,

AugustHergesheimer,

ShigenoriKumazawa:

Anthocyanins in mesocarp/epicarp andendocarp of fresh açai (Euterpe oleracea Mart.) and their antioxidant activities andbioavailability. Food Sci. Technol. Res. 2011, 17, 327-334.
49. Tomoko Tanaka, Takeshi Ishii, Daisuke Mizuno, Taiki Mori, Ryouichi Yamaji,
Yoshimasa Nakamura, Shigenori Kumazawa, Tsutomu Nakayama, Mitsugu Akagawa:(-)-Epigallocatechin-3-gallate-suppresses growth of AZ521 human gastric cancer cellsby targeting the DEAD box RNA helicase p68. Free Radic. Biol. Med. 2011, 50,1324-1335.
50. Yoshinori Uekusa, Miya Kamihira-Ishijima, Osamu Sugimoto, Takeshi Ishii,Shigenori Kumazawa, Kozo Nakamura, Ken-ichi Tanji, Akira Naito, Tsutomu
Nakayama: Interaction of epicatechin gallate with phospholipid membranes asrevealed by solid-state NMR spectroscopy. Biochim. Biophys. Acta - Biomembranes,
2011, 1808, 1654-1660.
51. Takeshi Ishii, Mitsugu Akagawa, Yuji Naito, Osamu Handa, Tomohisa Takagi, TaikiMori, Shigenori Kumazawa, Toshikazu Yoshikawa, Tsutomu Nakayama: Pro-oxidant
action of pyrroloquinoline quinone: characterization of protein oxidative modifications.
Biosci. Biotechnol. Biochem. 2010, 74, 663-666.
52. Shigenori Kumazawa, Mok-Ryeon Ahn, Takunori Fujimoto, and Masashi Kato:
Radical-scavenging activity and phenolic constituents of propolis from different
regions of Argentina. Nat. Prod. Res. 2010, 24, 804-812.

Award
1. Shigenori Kumazawa, World Class Professor Award, Republic of Indonesia 2018
2. Shigenori Kumazawa, Research Award at Society for Okinawa 2010
3. Shigenori Kumazawa, Research Award at The Japanese Society for Food Science andTechnology 2007
4. Shigenori Kumazawa, BBB Journal Award 2002

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