LEARN HOW RESEARCHERS AREUSING THE RNAscope™ TECHNOLOGYIN INFECTIOUS DISEASES RESEARCH
Context

Sensitivity

Speciﬁcity

Rapid

Strand-Speciﬁc

Detection withmorphologicalcontext provides viral
localization

High sensitivity
detects low viremia

High speciﬁcity
discerns closely
related viruses

Rapid probe design
enables detection of
any sequenced virus

Single-stranded andstrand-speciﬁc probes
discern viral stages

Detect any species
provided sequenceis known

Essential for
emerging viruses
without available
antibodies

Hybridizeto sense (+) or
anti-sense (-) strand
to detect replication,
resting stages

Entry portal,
replication site,
disease site,
shedding, viral
dynamics

Early infection andlatent stages

PUBLICATIONSBelow is a selection of articles demonstrating use of the RNAscope technology in various infectious disease researchgroups. There have been over 300 publications from various organizations since 2014 covering: MERS; ZIKV/Chickungunya; Hepatitis; Herpes/Varicella; HIV/SIV/FIV; Parvovirus; Other viruses; and HPV.

MERS
1.

Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus: J. v. d. B. Vergara-Alert, 		J. M.; Widagdo, W.; Munoz, M. th; Raj, S.; Schipper, D.; Solanes, D.; Cordon, I.; Bensaid, A.; Haagmans, B. L.;
Segales, J., Emerg Infect Dis 2017, PubMed ID: 27901465 - doi: 10.3201/eid2302.161239

2.

A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results: R. H. Y. Cha, S. H.; 		
Moon, K. C.; Joh, J. S.; Lee, J. Y.; Shin, H. S.; Kim, D. K.; Kim, Y. S., J Korean Med Sci 2016,
PubMed ID: 27051251 - doi: 10.3346/jkms.2016.31.4.635

3.

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory 		Tracts of Humans and Dromedary Camels: W. R. Widagdo, V. S.; Schipper, D.; Kolijn, K.; van Leenders, G. J.;
Bosch, B. J.; Bensaid, A.; Segales, J.; Baumgartner, W.; Osterhaus, A. D.; Koopmans, M. P.; van den Brand, J. M.;
Haagmans, B. L., J Virol 2016, PubMed ID: 26889022 - doi: 10.1128/jvi.02994-15

4.

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels:
B. L. v. d. B. Haagmans, J. M.; Raj, V. S.; Volz, A.; Wohlsein, P.; Smits, S. L.; Schipper, D.; Bestebroer, T. M.; Okba, N.;
Fux, R.; Bensaid, A.; Solanes Foz, D.; Kuiken, T.; Baumgartner, W.; Segales, J.; Sutter, G.; Osterhaus, A. D.,
Science 2016, PubMed ID: 26678878 - doi: 10.1126/science.aad1283

5.

Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits: B. L. v. d. B. Haagmans, J. M.;
Provacia, L. B.; Raj, V. S.; Stittelaar, K. J.; Getu, S.; de Waal, L.; Bestebroer, T. M.; van Amerongen, G.;
Verjans, G. M.; Fouchier, R. A.; Smits, S. L.; Kuiken, T.; Osterhaus, A. D., J Virol 2015,
PubMed ID: 25810539 - doi: 10.1128/jvi.00661-15

6.

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory 		Tracts of Humans and Dromedary Camels: W. R. Widagdo, V. S.; Schipper, D.; Kolijn, K.; van Leenders, Gjlh;
Bosch, B. J.; Bensaid, A.; Segales, J.; Baumgartner, W.; Osterhaus, Adme; Koopmans, M. P.; van den Brand, J. M. A.;
Haagmans, B. L., J Virol 2016, PubMed ID: 26889022 - doi: 10.1128/jvi.02994
Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDZIKV/Chikungunya
1.

Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila:
R. Zhang, J. T. Earnest, A. S. Kim, E. S. Winkler, P. Desai, L. J. Adams, G. Hu, C. Bullock, B. Gold, S. Cherry and
M. S. Diamond, Cell Rep 2019, PubMed ID: 31484075 - doi: 10.1016/j.celrep.2019.07.105

2.

Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent 		
RNA: A. R. Young, M. C. Locke, L. E. Cook, B. E. Hiller, R. Zhang, M. L. Hedberg, K. J. Monte, D. J. Veis, M. S. Diamondand D. J. Lenschow, PLoS Pathog 2019, PubMed ID: 31465513 - doi: 10.1371/journal.ppat.1007993

3.

Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcgammaRinteraction on monocytes: J. M. Fox, V. Roy, B. M. Gunn, L. Huang, M. A. Edeling, M. Mack, D. H. Fremont,
B. J. Doranz, S. Johnson, G. Alter and M. S. Diamond, Sci Immunol 2019,
PubMed ID: 30796092 - doi: 10.1126/sciimmunol.aav5062

4.

Interferon regulatory factor-1 (IRF-1) protects against chikungunya virus induced immunopathology by restricting
infection in muscle cells: S. P. Nair, S.; Shimak, R. M.; Diamond, M. S., J Virol 2017,
PubMed ID: 28835505 - doi: 10.1128/jvi.01419-17

5.

Countering Zika Virus: The USAMRIID Response: R. G. B. Lowen, T. M.; Kane, C. D.; Cazares, L. H.; Kota, K. P.;
Ladner, J. T.; Nasar, F.; Pitt, L.; Smith, D. R.; Soloveva, V.; Sun, M. G.; Zeng, X.; Bavari, S., Adv Exp Med Biol 2018, 		
PubMed ID: 29845541 - doi: 10.1007/978-981-10-8727-1_21

6.

Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance:
C. L. Vinton, S. J. Magaziner, K. A. Dowd, S. J. Robertson, E. Amaro-Carambot, E. P. Karmele, A. M. Ortiz, C. E. Starke,
J. C. Mudd, S. S. Whitehead, S. M. Best, T. C. Pierson, H. D. Hickman and J. M. Brenchley, mBio 2019,
PubMed ID: - doi: 10.1128/mBio.02790-19

7.

High susceptibility, viral dynamics and persistence of South American Zika virus in New World monkey species:
N. Berry, D. Ferguson, C. Ham, J. Hall, A. Jenkins, E. Giles, D. Devshi, S. Kempster, N. Rose, S. Dowall, M. Fritzsche,
T. Bleazard, R. Hewson and N. Almond, Scientific reports 2019,
PubMed ID: 31601848 - doi: 10.1038/s41598-019-50918-2

8.

Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine: I. K. Sariyer, J. Gordon,
T. H. Burdo, H. S. Wollebo, E. Gianti, M. Donadoni, A. Bellizzi, S. Cicalese, R. Loomis, J. A. Robinson, V. Carnevale,
J. Steiner, M. H. Ozdener, A. D. Miller, S. Amini, M. L. Klein and K. Khalili,
Molecular therapy : the journal of the American Society of Gene Therapy 2019,
PubMed ID: 31653397 - doi: 10.1016/j.ymthe.2019.10.006

9.

High susceptibility, viral dynamics and persistence of South American Zika virus in New World monkey species:
N. Berry, D. Ferguson, C. Ham, J. Hall, A. Jenkins, E. Giles, D. Devshi, S. Kempster, N. Rose, S. Dowall, M. Fritzsche,
T. Bleazard, R. Hewson and N. Almond, Sci Rep 2019, PubMed ID: 31601848 - doi: 10.1038/s41598-019-50918-2

10.

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus: A. Martinez-Lopez, M. Persaud,
M. P. Chavez, H. Zhang, L. Rong, S. Liu, T. T. Wang, S. G. Sarafianos and F. Diaz-Griffero, EBioMedicine 2019,
PubMed ID: - doi: https://doi.org/10.1016/j.ebiom.2019.08.060

11.

Zika virus production is resistant to RNase L antiviral activity: J. N. Whelan, Y. Li, R. H. Silverman and S. R. Weiss,
J Virol 2019, PubMed ID: 31142667 - doi: 10.1128/jvi.00313-19

12.

Zika virus causes acute infection and inflammation in the ovary of mice without apparent defects in fertility:
E. A. Caine, S. M. Scheaffer, D. E. Broughton, V. Salazar, J. Govero, S. Poddar, A. Osula, J. Halabi, M. E. Skaznik-Wikiel,
M. S. Diamond and K. H. Moley, J Infect Dis 2019, PubMed ID: 31063544 - doi: 10.1093/infdis/jiz239

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDZIKV/Chikungunya (continued)
13.

Atovaquone inhibits arbovirus replication through the depletion of intracellular nucleotides:
A. Cifuentes Kottkamp, E. De Jesus, R. Grande, J. A. Brown, A. R. Jacobs, J. K. Lim and K. A. Stapleford,
J Virol 2019, PubMed ID: 30894466 - doi: 10.1128/jvi.00389-19

14.

Clinical Importance of Placental Testing among Suspected Cases of Congenital Zika Syndrome: M. D. Seferovic,
M. Turley, G. C. Valentine, M. Rac, E. C. C. Castro, A. M. Major, B. Sanchez, C. Eppes, M. Sanz-Cortes, J. Dunn,
T. F. Kautz, J. Versalovic, K. L. Muldrew, T. Stout, M. A. Belfort, G. Demmler-Harrison and K. M. Aagaard,
Int J Mol Sci 2019, PubMed ID: 30736425 - doi: 10.3390/ijms20030712

15.

Zika virus infection in Tupaia belangeri causes dermatological manifestations and confers protection against
secondary infection: N. N. Zhang, L. Zhang, Y. Q. Deng, Y. Feng, F. Ma, Q. Wang, Q. Ye, Y. Han, X. Sun, F. C. Zhang,
X. Qi, G. Wang, J. Dai, X. Xia and C. F. Qin, J Virol 2019, PubMed ID: 30728253 - doi: 10.1128/jvi.01982-18

16.

Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy: J. A. Brown, G. Singh,
J. A. Acklin, S. Lee, J. E. Duehr, A. N. Chokola, J. J. Frere, K. W. Hoffman, G. A. Foster, D. Krysztof, R. Cadagan,
A. R. Jacobs, S. L. Stramer, F. Krammer, A. Garcia-Sastre and J. K. Lim, Immunity 2019,
PubMed ID: 30737148 - doi: 10.1016/j.immuni.2019.01.005

17.

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection
and Pathogenesis in Mice: V. Salazar, B. W. Jagger, J. Mongkolsapaya, K. E. Burgomaster, W. Dejnirattisai,
E. S. Winkler, E. Fernandez, C. A. Nelson, D. H. Fremont, T. C. Pierson, J. E. Crowe, Jr., G. R. Screaton and
M. S. Diamond, Cell Rep 2019, PubMed ID: 30726740 - doi: 10.1016/j.celrep.2019.01.052

18.

Interferon lambda protects the female reproductive tract against Zika virus infection: E. A. Caine, S. M. Scheaffer,
N. Arora, K. Zaitsev, M. N. Artyomov, C. B. Coyne, K. H. Moley and M. S. Diamond, Nature Communications 2019, 		
PubMed ID: 30655513 - doi: 10.1038/s41467-018-07993-2

19.

Zika virus shedding in the stool and infection through the anorectal mucosa in mice: C. D. Li, Y. Q.; Zu, S.;
Quanquin, N.; Shang, J.; Tian, M.; Ji, X.; Zhang, N. N.; Dong, H. L.; Xu, Y. P.; Zhao, L. Z.; Zhang, F. C.; Li, X. F.; Wu, A.;
Cheng, G.; Qin, C. F., Emerg Microbes Infect 2018, PubMed ID: 30333476 - doi: 10.1038/s41426-018-0170-6

20.

Preliminary Studies on Immune Response and Viral Pathogenesis of Zika Virus in Rhesus Macaques:
S. M. O. Woollard, O. A.; Dutta, D.; Dave, R. S.; Mathews, S.; Gorantla, S.; Johnson, N.; Giavedoni, L.;
Norgren, R. B., Jr.; Byrareddy, S. N., Pathogens 2018, PubMed ID: 30127237 - doi: 10.3390/pathogens7030070

21.

Zika virus infects human testicular tissue and germ cells: G. H. Matusali, L.; Satie, A. P.; Mahe, D.; Aubry, F.;
Couderc, T.; Frouard, J.; Bourgeau, S.; Bensalah, K.; Lavoue, S.; Joguet, G.; Bujan, L.; Cabie, A.; Avelar, G. F.;
Lecuit, M.; Le Tortorec, A.; Dejucq-Rainsford, N., J Clin Invest 2018, PubMed ID: 30063220 - doi: 10.1172/jci121735

22.

Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease:
L. L. K. Coffey, R. I.; Pesavento, P. A.; Woolard, K.; Singapuri, A.; Watanabe, J.; Cruzen, C.; Christe, K. L.; Usachenko, J.;
Yee, J.; Heng, V. A.; Bliss-Moreau, E.; Reader, J. R.; von Morgenland, W.; Gibbons, A. M.; Jackson, K.; Ardeshir, A.;
Heimsath, H.; Permar, S.; Senthamaraikannan, P.; Presicce, P.; Kallapur, S. G.; Linnen, J. M.; Gao, K.; Orr, R.;
MacGill, T.; McClure, M.; McFarland, R.; Morrison, J. H.; Van Rompay, K. K. A., Nat Commun 2018,
PubMed ID: 29925843 - doi: 10.1038/s41467-018-04777-6

23.

Timing of Gestational Exposure to Zika Virus is Associated with Postnatal Growth Restriction in a Murine Model: 		
G. C. S. Valentine, M. D.; Fowler, S. W.; Major, A. M.; Gorchakov, R.; Berry, R.; Swennes, A. G.; Murray, K. O.;
Suter, M. A.; Aagaard, K. M., Am J Obstet Gynecol 2018, PubMed ID: 29902449 - doi: 10.1016/j.ajog.2018.06.005

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDZIKV/Chikungunya (continued)
24.

An Immunocompetent Mouse Model of Zika Virus Infection: M. J. C. Gorman, E. A.; Zaitsev, K.; Begley, M. C.;
Weger-Lucarelli, J.; Uccellini, M. B.; Tripathi, S.; Morrison, J.; Yount, B. L.; Dinnon, K. H., 3rd; Ruckert, C.; Young, M. C.;
Zhu, Z.; Robertson, S. J.; McNally, K. L.; Ye, J.; Cao, B.; Mysorekar, I. U.; Ebel, G. D.; Baric, R. S.; Best, S. M.;
Artyomov, M. N.; Garcia-Sastre, A.; Diamond, M. S., Cell Host Microbe 2018,
PubMed ID: 29746837 - doi: 10.1016/j.chom.2018.04.003

25.

Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and
Neurodevelopmental Abnormalities: M. M. Seferovic, C. S.; Tardif, S. D.; Rutherford, J.; Castro, E. C. C.; Li, T.;
Hodara, V. L.; Parodi, L. M.; Giavedoni, L.; Layne-Colon, D.; Tamhankar, M.; Yagi, S.; Martyn, C.; Reyes, K.; Suter, M. A.;
Aagaard, K. M.; Chiu, C. Y.; Patterson, J. L., Sci Rep 2018, PubMed ID: 29717225 - doi: 10.1038/s41598-018-25205-1

26.

A novel sheet-like virus particle array is a hallmark of Zika virus infection: J. K. Liu, B. A.; Kenny, T. A.; Smith, D. R.;
Soloveva, V.; Beitzel, B.; Pang, S.; Lockett, S.; Hess, H. F.; Palacios, G.; Kuhn, J. H.; Sun, M. G.; Zeng, X.,
Emerg Microbes Infect 2018, PubMed ID: 29691373 - doi: 10.1038/s41426-018-0071-8

27.

Lethal Zika Virus Disease Models in Young and Older Interferon alpha/beta Receptor Knock Out Mice:A. E. Marzi, J.; Callison, J.; McNally, K. L.; Arndt, N.; Chadinha, S.; Martellaro, C.; Rosenke, R.; Scott, D. P.;
Safronetz, D.; Whitehead, S. S.; Best, S. M.; Feldmann, H., Front Cell Infect Microbiol 2018,
PubMed ID: 29696134 - doi: 10.3389/fcimb.2018.00117

28.

Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior
in infant macaques: M. R. Mavigner, J.; Kovacs-Balint, Z.; Gumber, S.; O’Neal, J. T.; Bhaumik, S. K.; Zhang, X.;
Habib, J.; Mattingly, C.; McDonald, C. E.; Avanzato, V.; Burke, M. W.; Magnani, D. M.; Bailey, V. K.; Watkins, D. I.;
Vanderford, T. H.; Fair, D.; Earl, E.; Feczko, E.; Styner, M.; Jean, S. M.; Cohen, J. K.; Silvestri, G.; Johnson, R. P.;
O’Connor, D. H.; Wrammert, J.; Suthar, M. S.; Sanchez, M. M.; Alvarado, M. C.; Chahroudi, A., Sci Transl Med 2018, 		
PubMed ID: 29618564 - doi: 10.1126/scitranslmed.aao6975

29.

Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys: A. J. A. Martinot, P.; Afacan, O.;
Prohl, A. K.; Bronson, R.; Hecht, J. L.; Borducchi, E. N.; Larocca, R. A.; Peterson, R. L.; Rinaldi, W.; Ferguson, M.;
Didier, P. J.; Weiss, D.; Lewis, M. G.; De La Barrera, R. A.; Yang, E.; Warfield, S. K.; Barouch, D. H., Cell 2018,
PubMed ID: 29606355 - doi: 10.1016/j.cell.2018.03.019

30.

Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice:
D. J. S. Platt, A. M.; Arora, N.; Diamond, M. S.; Coyne, C. B.; Miner, J. J., Sci Transl Med 2018,
PubMed ID: 29386359 - doi: 10.1126/scitranslmed.aao7090

31.

Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection:
E. L. B. Mohr, L. N.; Newman, C. M.; Stewart, L. M.; Koenig, M.; Semler, M.; Breitbach, M. E.; Teixeira, L. B. C.;
Zeng, X.; Weiler, A. M.; Barry, G. L.; Thoong, T. H.; Wiepz, G. J.; Dudley, D. M.; Simmons, H. A.; Mejia, A.;
Morgan, T. K.; Salamat, M. S.; Kohn, S.; Antony, K. M.; Aliota, M. T.; Mohns, M. S.; Hayes, J. M.; Schultz-Darken, N.;
Schotzko, M. L.; Peterson, E.; Capuano, S., 3rd; Osorio, J. E.; O’Connor, S. L.; Friedrich, T. C.; O’Connor, D. H.;
Golos, T. G., PLoS One 2018, PubMed ID: 29381706 - doi: 10.1371/journal.pone.0190617

32.

AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling: J. Y. Chen, Y. F.; Yang,Y.;
Zou, P.; Chen, J.; He, Y.; Shui, S. L.; Cui, Y. R.; Bai, R.; Liang, Y. J.; Hu, Y.; Jiang, B.; Lu, L.; Zhang, X.; Liu, J.; Xu, J.,
Nat Microbiol 2018, PubMed ID: 29379210 - doi: 10.1038/s41564-017-0092-4

33.

Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice: J. M. L. Scott, T. J.;
Richner, J. M.; Jiang, X.; Fernandez, E.; Zhao, H.; Fremont, D. H.; Diamond, M. S.; Shin, H., J Virol 2018,
PubMed ID: 29343577 - doi: 10.1128/jvi.00038-18

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CONTINUEDZIKV/Chikungunya (continued)
34.

Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation ina 5-Month Infant With Congenital Zika Syndrome: L. M. P. Chimelli, S.; Avvad-Portari, E.; Farias Meira Vasconcelos, Z.;
Araujo Zin, A.; Prado Cunha, D.; Raposo Thompson, N.; Lopes Moreira, M. E.; Wiley, C. A.; da Silva Pone, M. V.,
J Neuropathol Exp Neurol 2018, PubMed ID: 29346650 - doi: 10.1093/jnen/nlx116

35.

Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection:
E. D. Fernandez, W.; Cao, B.; Scheaffer, S. M.; Supasa, P.; Wongwiwat, W.; Esakky, P.; Drury, A.; Mongkolsapaya, J.;
Moley, K. H.; Mysorekar, I. U.; Screaton, G. R.; Diamond, M. S., Nat Immunol 2017,
PubMed ID: 28945244 - doi: 10.1038/ni.3849

36.

Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects:
J. Y. Chen, Y. F.; Chen, J.; Zhou, X.; Dong, Z.; Chen, T.; Yang, Y.; Zou, P.; Jiang, B.; Hu, Y.; Lu, L.; Zhang, X.; Liu, J.; Xu, J.;
Zhu, T., Emerg Microbes Infect 2017, PubMed ID: 28831192 - doi: 10.1038/emi.2017.67

37.

Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring:
J. C. Darbellay, Brian; Lai, Kenneth; Delgado-Ortega, Mario; Wheler, Colette; Wilson, Donald; Walker, Stewart;
Starrak, Gregory; Hockley, Duncan; Huang, Yanyun; Mutwiri, George; Potter, Andrew; Gilmour, Matthew;
Safronetz, David; Gerdts, Volker; Karniychuk, Uladzimir, EBioMedicine 2017,
PubMed ID: - doi: 10.1016/j.ebiom.2017.09.021

38.

Gestational Stage and IFN-lambda Signaling Regulate ZIKV Infection In Utero: B. W. M. Jagger, J. J.; Cao, B.;
Arora, N.; Smith, A. M.; Kovacs, A.; Mysorekar, I. U.; Coyne, C. B.; Diamond, M. S., Cell Host Microbe 2017, 		
PubMed ID: 28910635 - doi: 10.1016/j.chom.2017.08.012

39.

[18F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice: K. H. Kuszpit, B. S.; 		
Zeng, X.; Stafford, R. G.; Daye, S.; Zhang, X.; Basuli, F.; Golden, J. W.; Swenson, R. E.; Smith, D. R.; Bocan, T. M., 		
Mol Imaging Biol 2017, PubMed ID: 28900831 - doi: 10.1007/s11307-017-1118-2

40.

Zika virus has oncolytic activity against glioblastoma stem cells: Z. G. Zhu, Matthew J.; McKenzie, Lisa D.;
Chai, Jiani N.; Hubert, Christopher G.; Prager, Briana C.; Fernandez, Estefania; Richner, Justin M.; Zhang, Rong; 		
Shan, Chao; Wang, Xiuxing; Shi, Pei-Yong; Diamond, Michael S.; Rich, Jeremy N.; Chheda, Milan G.,
The Journal of Experimental Medicine 2017, PubMed ID: 28874392 - doi: 10.1084/jem.20171093

41.

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice: B. P. Cao, L. A.;
Diamond, M. S.; Mysorekar, I. U., J Exp Med 2017, PubMed ID: 28694387 - doi: 10.1084/jem.20170957

42.

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease: J. M. J. Richner, Brett W.; Shan, Chao;
Fontes, Camila R.; Dowd, Kimberly A.; Cao, Bin; Himansu, Sunny; Caine, Elizabeth A.; Nunes, Bruno T. D.;
Medeiros, Daniele B. A.; Muruato, Antonio E.; Foreman, Bryant M.; Luo, Huanle; Wang, Tian; Barrett, Alan D.;
Weaver, Scott C.; Vasconcelos, Pedro F. C.; Rossi, Shannan L.; Ciaramella, Giuseppe; Mysorekar, Indira U.;
Pierson, Theodore C.; Shi, Pei-Yong; Diamond, Michael S., Cell 2017,
PubMed ID: 28708997 - doi: 10.1016/j.cell.2017.06.040

43.

Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor
knockout (A129) mice: S. D. G. Dowall, V. A.; Rayner, E.; Hunter, L.; Atkinson, B.; Pearson, G.; Dennis, M.;
Hewson, R., PLoS Negl Trop Dis 2017, PubMed ID: 28672028 - doi: 10.1371/journal.pntd.0005704

44.

TAM Receptors Are Not Required for Zika Virus Infection in Mice: A. K. Y. Hastings, L. J.; Jagger, B. W.; Hwang, J.; 		
Uraki, R.; Gaitsch, H. F.; Parnell, L. A.; Cao, B.; Mysorekar, I. U.; Rothlin, C. V.; Fikrig, E.; Diamond, M. S.; Iwasaki, A.,
Cell Rep 2017, PubMed ID: 28423319 - doi: 10.1016/j.celrep.2017.03.058

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CONTINUEDZIKV/Chikungunya (continued)
45.

The spectrum of neuropathological changes associated with congenital Zika virus infection: L. M. Chimelli, A. S.; 		
Avvad-Portari, E.; Wiley, C. A.; Camacho, A. H.; Lopes, V. S.; Machado, H. N.; Andrade, C. V.; Dock, D. C.;
Moreira, M. E.; Tovar-Moll, F.; Oliveira-Szejnfeld, P. S.; Carvalho, A. C.; Ugarte, O. N.; Batista, A. G.; Amorim, M. M.; 		
Melo, F. O.; Ferreira, T. A.; Marinho, J. R.; Azevedo, G. S.; Leal, J. I.; da Costa, R. F.; Rehen, S.; Arruda, M. B.;
Brindeiro, R. M.; Delvechio, R.; Aguiar, R. S.; Tanuri, A., Acta Neuropathol 2017,
PubMed ID: 28332092 - doi: 10.1007/s00401-017-1699-5

46.

Adaptive Immune Responses to Zika Virus Are Important for Controlling Virus Infection and Preventing Infectionin Brain and Testes: C. W. M. Winkler, L. M.; Woods, T. A.; Messer, R. J.; Carmody, A. B.; McNally, K. L.; Scott, D. P.;
Hasenkrug, K. J.; Best, S. M.; Peterson, K. E., J Immunol 2017,
PubMed ID: 28330900 - doi: 10.4049/jimmunol.1601949

47.

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues: A. J. S. Hirsch, J. L.;
Haese, N. N.; Broeckel, R. M.; Parkins, C. J.; Kreklywich, C.; DeFilippis, V. R.; Denton, M.; Smith, P. P.; Messer, W. B.;
Colgin, L. M.; Ducore, R. M.; Grigsby, P. L.; Hennebold, J. D.; Swanson, T.; Legasse, A. W.; Axthelm, M. K.;
MacAllister, R.; Wiley, C. A.; Nelson, J. A.; Streblow, D. N., PLoS Pathog 2017,
PubMed ID: 28278237 - doi: 10.1371/journal.ppat.1006219

48.

Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody
Blockade of Type I Interferon: D. R. H. Smith, B.; Daye, S.; Zeng, X.; Blancett, C.; Kuszpit, K.; Bocan, T.;
Koehler, J. W.; Coyne, S.; Minogue, T.; Kenny, T.; Chi, X.; Yim, S.; Miller, L.; Schmaljohn, C.; Bavari, S.; Golden, J. W.,
PLoS Negl Trop Dis 2017, PubMed ID: 28068342 - doi: 10.1371/journal.pntd.0005296

49.

Zika Virus RNA Replication and Persistence in Brain and Placental Tissue: J. R. Bhatnagar, D. B.; Martines, R. B.;
Reagan-Steiner, S.; Ermias, Y.; Estetter, L. B.; Suzuki, T.; Ritter, J.; Keating, M. K.; Hale, G.; Gary, J.; Muehlenbachs, A.;
Lambert, A.; Lanciotti, R.; Oduyebo, T.; Meaney-Delman, D.; Bolanos, F.; Saad, E. A.; Shieh, W. J.; Zaki, S. R.,
Emerg Infect Dis 2017, PubMed ID: 27959260 - doi: 10.3201/eid2303.161499

50.

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice: G. F. Sapparapu, E.;
Kose, N.; Bin, Cao; Fox, J. M.; Bombardi, R. G.; Zhao, H.; Nelson, C. A.; Bryan, A. L.; Barnes, T.; Davidson, E.;
Mysorekar, I. U.; Fremont, D. H.; Doranz, B. J.; Diamond, M. S.; Crowe, J. E., Nature 2016,
PubMed ID: 27819683 - doi: 10.1038/nature20564

51.

Zika virus infection damages the testes in mice: J. E. Govero, P.; Scheaffer, S. M.; Fernandez, E.; Drury, A.; Platt, D. J.;
Gorman, M. J.; Richner, J. M.; Caine, E. A.; Salazar, V.; Moley, K. H.; Diamond, M. S., Nature 2016,
PubMed ID: 27798603 - doi: 10.1038/nature20556

52.

Miscarriage Associated with Zika Virus Infection: A. A. v. G. van der Eijk, P. J.; Verdijk, R. M.; Reusken, C. B.;
Mogling, R.; van Kampen, J. J.; Widagdo, W.; Aron, G. I.; GeurtsvanKessel, C. H.; Pas, S. D.; Raj, V. S.; Haagmans, B. L.;
Koopmans, M. P., N Engl J Med 2016, PubMed ID: 27463941 - doi: 10.1056/NEJMc1605898

53.

Zika viral dynamics and shedding in rhesus and cynomolgus macaques: C. E. L. Osuna, S. Y.; Deleage, C.;
Griffin, B. D.; Stein, D.; Schroeder, L. T.; Omange, R.; Best, K.; Luo, M.; Hraber, P. T.; Andersen-Elyard, H.; Ojeda, E. F.;
Huang, S.; Vanlandingham, D. L.; Higgs, S.; Perelson, A. S.; Estes, J. D.; Safronetz, D.; Lewis, M. G.; Whitney, J. B.,
Nat Med 2016, PubMed ID: 27694931 - doi: 10.1038/nm.4206

54.

Placental Pathology of Zika Virus: Viral Infection of the Placenta Induces Villous Stromal Macrophage (Hofbauer
Cell) Proliferation and Hyperplasia: A. Z. Y. Rosenberg, W.; Hill, D. A.; Reyes, C. A.; Schwartz, D. A.,
Arch Pathol Lab Med 2017, PubMed ID: 27681334 - doi: 10.5858/arpa.2016-0401-OA

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CONTINUEDZIKV/Chikungunya (continued)
55.

Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears: J. J. S. Miner, A.; Richner, J. M.;
Smith, A. M.; Santeford, A.; Ban, N.; Weger-Lucarelli, J.; Manzella, F.; Ruckert, C.; Govero, J.; Noguchi, K. K.;
Ebel, G. D.; Diamond, M. S.; Apte, R. S., Cell Rep 2016, PubMed ID: 27612415 - doi: 10.1016/j.celrep.2016.08.079

56.

The spectrum of neuropathological changes associated with congenital Zika virus infection: L. M. Chimelli, A. S. O.;
Avvad-Portari, E.; Wiley, C. A.; Camacho, A. H. S.; Lopes, V. S.; Machado, H. N.; Andrade, C. V.; Dock, D. C. A.;
Moreira, M. E.; Tovar-Moll, F.; Oliveira-Szejnfeld, P. S.; Carvalho, A. C. G.; Ugarte, O. N.; Batista, A. G. M.;
Amorim, M. M. R.; Melo, F. O.; Ferreira, T. A.; Marinho, J. R. L.; Azevedo, G. S.; Leal, Jibf; da Costa, R. F. M.; Rehen, S.;
Arruda, M. B.; Brindeiro, R. M.; Delvechio, R.; Aguiar, R. S.; Tanuri, A., Acta Neuropathol 2017,
PubMed ID: 28332092 - doi: 10.1007/s00401-017-1699-5

Hepatitis
1.

Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals 		
against Hepatitis C Virus: D. Liu, P. R. Tedbury, S. Lan, A. D. Huber, M. N. Puray-Chavez, J. Ji, E. Michailidis, M. Saeed,
T. P. Ndongwe, L. C. Bassit, R. F. Schinazi, R. Ralston, C. M. Rice and S. G. Sarafianos, Viruses 2019,
PubMed ID: 31717338 - doi: 10.3390/v11111039

2.

Highly diversified shrew hepatitis B viruses corroborate ancient origins and divergent infection patterns ofmammalian hepadnaviruses: A. Rasche, F. Lehmann, A. Konig, N. Goldmann, V. M. Corman, A. Moreira-Soto,
A. Geipel, D. van Riel, Y. A. Vakulenko, A. L. Sander, H. Niekamp, R. Kepper, M. Schlegel, C. Akoua-Koffi, B. Souza,
F. Sahr, A. Olayemi, V. Schulze, R. Petraityte-Burneikiene, A. Kazaks, K. Lowjaga, J. Geyer, T. Kuiken, C. Drosten,
A. N. Lukashev, E. Fichet-Calvet, R. G. Ulrich, D. Glebe and J. F. Drexler, Proc Natl Acad Sci 2019,
PubMed ID: 31371507 - doi: 10.1073/pnas.1908072116

3.

A Novel Hepadnavirus is Associated with Chronic Hepatitis and Hepatocellular Carcinoma in Cats: P. A. Pesavento,
K. Jackson, T. S. T. T. B. Hampson, J. S. Munday, V. R. Barrs and J. A. Beatty, Viruses 2019,
PubMed ID: 31640283 - doi: 10.3390/v11100969

4.

Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma: J. Shimono, H. Miyoshi,
F. Arakawa, K. Yamada, T. Sugio, K. Miyawaki, T. Eto, T. Miyagishima, K. Kato, K. Nagafuji, K. Akashi, T. Teshima and
K. Ohshima, Annals of Hematology 2019, PubMed ID: 30729289 - doi: 10.1007/s00277-019-03628-8

5.

Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface: J. C. Gouilly, Q.;
Siewiera, J.; Cartron, G.; Levy, C.; Dubois, M.; Al-Daccak, R.; Izopet, J.; Jabrane-Ferrat, N.; El Costa, H.,
Nat Commun 2018, PubMed ID: 30420629 - doi: 10.1038/s41467-018-07200-2

6.

Hepatitis B virus deregulates cell cycle to promote viral replication and a premalignant phenotype: Y. C. Xia, X.;
Li, Y.; Valdez, K.; Chen, W.; Liang, T. J., J Virol 2018, PubMed ID: 30021897 - doi: 10.1128/jvi.00722-18

7.

Hepatic immunopathology during occult hepacivirus re-infection: C. M. Manickam, A. J.; Jones, R. A.; Varner, V.;
Reeves, R. K., Virology 2017, PubMed ID: 28915405 - doi: 10.1016/j.virol.2017.08.037

8.

Relationship between serum HBV RNA levels and intrahepatic viral as well as histologic activity markers inentecavir-treated patients: J. Y. Wang, Y.; Li, G.; Shen, C.; Meng, Z.; Zheng, J.; Jia, Y.; Chen, S.; Zhang, X.; Zhu, M.; 		
Zheng, J.; Song, Z.; Wu, J.; Shao, L.; Qian, P.; Mao, X.; Wang, X.; Huang, Y.; Zhao, C.; Zhang, J.; Qiu, C.; Zhang, W.,
J Hepatol 2017, PubMed ID: 28870671 - doi: 10.1016/j.jhep.2017.08.021

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CONTINUED

Hepatitis (continued)
9.

Viral persistence, liver disease and host response in Hepatitis C-like virus rat model: S. M. Trivedi, Satyapramod; 		
Sharma, Himanshu; Hartlage, Alex S.; Kumar, Arvind; Gadi, Sashi; Simmonds, Peter; Chauhan, Lokendra V.;
Scheel, Troels K. H.; Billerbeck, Eva; Burbelo, Peter D.; Rice, Charles M.; Lipkin, W. Ian; Vandergrift, Kurt;
Cullen, John M.; Kapoor, Amit, Hepatology 2017, PubMed ID: 28859226 - doi: 10.1002/hep.29494

10.

Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected
humanized mice: K. H. Giersch, M.; Volz, T.; Helbig, M.; Allweiss, L.; Lohse, A. W.; Petersen, J.; Buti, M.; Pollicino, T.; 		
Sureau, C.; Dandri, M.; Lutgehetmann, M., Sci Rep 2017, PubMed ID: 28623307 - doi: 10.1038/s41598-017-03946-9

11.

Detection of viral hepatitis E in clinical liver biopsies: S. C. Prost, C. L.; Dalton, H. R.; De Man, R. A.; Kamar, N.;
Selves, J.; Dhaliwal, C.; Scobie, L.; Bellamy, C. O. C., Histopathology 2017,
PubMed ID: 28543644 - doi: 10.1111/his.13266

12.

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete 		nuclear cccDNA in vivo: L. V. Allweiss, T.; Giersch, K.; Kah, J.; Raffa, G.; Petersen, J.; Lohse, A. W.; Beninati, C.;
Pollicino, T.; Urban, S.; Lutgehetmann, M.; Dandri, M., Gut 2017,
PubMed ID: 28428345 - doi: 10.1136/gutjnl-2016-312162

13.

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-hostinteractions: Y. C. Xia, A.; Cheng, X.; Block, P. D.; Zhao, Y.; Zhang, Z.; Protzer, U.; Liang, T. J., J Hepatol 2016,
PubMed ID: 27746336 - doi: 10.1016/j.jhep.2016.10.009

14.

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation:
L. G. Allweiss, S.; Giersch, K.; Groth, A.; Kah, J.; Volz, T.; Rapp, G.; Schobel, A.; Lohse, A. W.; Polywka, S.; Pischke, S.; 		
Herker, E.; Dandri, M.; Lutgehetmann, M., J Hepatol 2016, PubMed ID: 26805671 - doi: 10.1016/j.jhep.2016.01.011

15.

Evolutionary origins of hepatitis A virus in small mammals: J. F. C. Drexler, V. M.; Lukashev, A. N.;
van den Brand, J. M.; Gmyl, A. P.; Brunink, S.; Rasche, A.; Seggewibeta, N.; Feng, H.; Leijten, L. M.; Vallo, P.;
Kuiken, T.; Dotzauer, A.; Ulrich, R. G.; Lemon, S. M.; Drosten, C., Proc Natl Acad Sci 2015,
PubMed ID: 26575627 - doi: 10.1073/pnas.1516992112

16.

Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome: E. G. W. Meissner, D.;
Osinusi, A.; Bon, D.; Virtaneva, K.; Sturdevant, D.; Porcella, S.; Wang, H.; Herrmann, E.; McHutchison, J.;
Suffredini, A. F.; Polis, M.; Hewitt, S.; Prokunina-Olsson, L.; Masur, H.; Fauci, A. S.; Kottilil, S., J Clin Invest 2014, 		
PubMed ID: 24983321 - doi: 10.1172/jci75938

17.

Evidence for novel hepaciviruses in rodents: J. F. C. Drexler, V. M.; Muller, M. A.; Lukashev, A. N.; Gmyl, A.;
Coutard, B.; Adam, A.; Ritz, D.; Leijten, L. M.; van Riel, D.; Kallies, R.; Klose, S. M.; Gloza-Rausch, F.; Binger, T.;
Annan, A.; Adu-Sarkodie, Y.; Oppong, S.; Bourgarel, M.; Rupp, D.; Hoffmann, B.; Schlegel, M.; Kummerer, B. M.;
Kruger, D. H.; Schmidt-Chanasit, J.; Setien, A. A.; Cottontail, V. M.; Hemachudha, T.; Wacharapluesadee, S.;
Osterrieder, K.; Bartenschlager, R.; Matthee, S.; Beer, M.; Kuiken, T.; Reusken, C.; Leroy, E. M.; Ulrich, R. G.;
Drosten, C., PLoS Pathog 2013, PubMed ID: 23818848 - doi: 10.1371/journal.ppat.1003438

Herpes/Varicella1.

Induction of Kaposi Sarcoma Associated Herpesvirus-encoded Thymidine Kinase (ORF21) by X-Box Binding
Protein-1: V. Wang, D. A. Davis, C. Deleage, C. Brands, H. S. Choi, M. Haque and R. Yarchoan,
Journal of virology 2019, PubMed ID: 31801863 - doi: 10.1128/JVI.01555-19

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CONTINUED

Herpes/Varicella (continued)
2.

Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques:
A. A. Okoye, M. Q. DeGottardi, Y. Fukazawa, M. Vaidya, C. O. Abana, A. L. Konfe, D. N. Fachko, D. M. Duell, H. Li,
R. Lum, L. Gao, B. S. Park, R. L. Skalsky, A. D. Lewis, M. K. Axthelm, J. D. Lifson, S. W. Wong and L. J. Picker,
J Immunol 2019, PubMed ID: 31653683 - doi: 10.4049/jimmunol.1900792

3.

Identification of Host Biomarkers of Epstein-Barr Virus Latency IIb and Latency III: J. E. Messinger, J. Dai,
L. J. Stanland, A. M. Price and M. A. Luftig, American Society of Microbiology 2019,
PubMed ID: - doi: 10.1128/mBio.01006-19

4.

Two Cases of Equine Multinodular Pulmonary Fibrosis in Japan: A. Ochi, M. Sekiguchi, K. Tsujimura,
T. Kinoshita, T. Ueno and Y. Katayama, Journal of Comparative Pathology 2019,
PubMed ID: - doi: https://doi.org/10.1016/j.jcpa.2019.05.007

5.

Novel Herpesvirus Associated With Oropharyngeal Squamous Cell Carcinoma in Smooth Green Snakes(Opheodrys vernalis): J. N. Lovstad, R. J. Ossiboff, M. J. Kinsel and K. C. Gamble, Vet Pathol 2019,
PubMed ID: 30983531 - doi: 10.1177/0300985819837722

6.

Modeling HSV-1 infections in human CNS neuronal cells using two-dimensional and three-dimensional culturesderived from induced pluripotent stem cells: L. D’Aiuto, D. C. Bloom, J. N. Naciri, A. Smith, T. G. Edwards, L. McClain,
J. A. Callio, M. Jessup, J. Wood, K. Chowdari, M. Demers, E. E. Abrahamson, M. D. Ikonomovic, L. Viggiano, R. De Zio,
S. Watkins, P. R. Kinchington and V. L. Nimgaonkar, J Virol 2019, PubMed ID: 30787148 - doi: 10.1128/jvi.00111-19

7.

Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch But Not Pain Signals: G. W. Albisetti,
M. Pagani, E. Platonova, L. Hosli, H. C. Johannssen, J. M. Fritschy, H. Wildner and H. U. Zeilhofer, J Neurosci 2019, 		
PubMed ID: 30655357 - doi: 10.1523/jneurosci.2559-18.2019

8.

Lund Human Mesencephalic (LUHMES) Neuronal Cell Line Supports HSV-1 Latency in vitro: T. G. Edwards and
D. C. Bloom, J Virol 2019, PubMed ID: 30602607 - doi: 10.1128/jvi.02210-18

9.

Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome isco-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins:
K. Pheasant, C. S. Moller-Levet, J. Jones, D. Depledge, J. Breuer and G. Elliott, PLoS Pathog 2018,
PubMed ID: 30475899 - doi: 10.1371/journal.ppat.1007331

10.

In Situ Hybridization for Localization of Ovine Herpesvirus 2, the Agent of Sheep-Associated Malignant Catarrhal
Fever, in Formalin-Fixed Tissues: P. A. C. Pesavento, C. W.; Li, H.; Jackson, K.; O’Toole, D., Vet Pathol 2018,
PubMed ID: 30222071 - doi: 10.1177/0300985818798085

11.

Systemic Necrotizing Vasculitis in Sheep Is Associated With Ovine Herpesvirus 2: P. A. D. Pesavento, R. B.;
Ferreras, M. C.; Dasjerdi, A.; Perez, V.; LaRoca, A.; Silvan, J. B.; Diab, S.; Jackson, K.; Phillips, I. L.; Li, H.; Cunha, C. W.;
Wessels, M., Vet Pathol 2018, PubMed ID: 30200830 - doi: 10.1177/0300985818795166

12.

Multiple post-transcriptional strategies to regulate the herpes simplex virus type 1 vhs endoribonuclease:
G. P. El-liott, K.; Ebert-Keel, K.; Stylianou, J.; Franklyn, A.; Jones, J., J Virol 2018,
PubMed ID: 29925667 - doi: 10.1128/jvi.00818-18

13.

RESTRICTION OF gamma34.5-DELETED ONCOLYTIC HERPES SIMPLEX VIRUS REPLICATION IN GLIOBLASTOMA
STEM-LIKE CELLS: C. P. Peters, M.; Tshilenge, K. T.; Saha, D.; Antoszczyk, S.; Baars, A.; Frost, T.; Martuza, R. L.; 		
Wakimoto, H.; Rabkin, S. D., J Virol 2018, PubMed ID: 29793956 - doi: 10.1128/jvi.00246-18

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CONTINUED

Herpes/Varicella (continued)
14.

Simian Varicella Virus Infects Enteric Neurons and alpha4beta7 Integrin-Expressing Gut-Tropic T-Cells in NonhumanPrimates: W. J. D. v. V. Ouwendijk, S.; Mehraban, T.; Mahalingam, R.; Verjans, Gmgm, Viruses 2018,
PubMed ID: 29597335 - doi: 10.3390/v10040156

15.

A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61:
D. P. O. Depledge, W. J. D.; Sadaoka, T.; Braspenning, S. E.; Mori, Y.; Cohrs, R. J.; Verjans, Gmgm; Breuer, J.,
Nat Commun 2018, PubMed ID: 29563516 - doi: 10.1038/s41467-018-03569-2

16.

Identification of Epstein-Barr Virus in the Human Placenta and Its Pathologic Characteristics: Y. K. Kim, Hye Sung; 		
Park, Joong Shin; Kim, Chong Jai; Kim, Woo Ho, J Korean Med Sci 2017,
PubMed ID: 29115077 - doi: 10.3346/jkms.2017.32.12.1959

17.

Naturally Acquired Canine Herpesvirus-Associated Meningoencephalitis: M. C. S. Jager, E. A.; Shelton, M.;
Miller, A. D., Vet Pathol 2017, PubMed ID: 28655291 - doi: 10.1177/0300985817716263

18.

Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation:
T. C. Peng, R. Savanh; Sun, Sijie; Trigilio, James A.; Phasouk, Khamsone; Jin, Lei; Layton, Erik D.; Li, Alvason Z.;
Correnti, Colin E.; De van der Schueren, Willem; Vazquez, Julio; O’Day, Diana R.; Glass, Ian A.; Knipe, David M.; 		
Wald, Anna; Corey, Law-rence; Zhu, Jia, The Journal of Experimental Medicine 2017,
PubMed ID: 28663436 - doi: 10.1084/jem.20160581

19.

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis:
T. K. Xia, H.; Barber, G. N., Cancer Res 2016, PubMed ID: 27680683 - doi: 10.1158/0008-5472.can-16-1404

20.

Primate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting thepresence of a pro-/anti-inflammatory axis: M. M. B. Sauter, C. R., Exp Eye Res 2016,
PubMed ID: 27170050 - doi: 10.1016/j.exer.2016.05.003

21.

Alphaherpesvirus Latency: A Dynamic State of Transcription and Reactivation: D. C. Bloom, Adv Virus Res 2016, 		
PubMed ID: 26997590 - doi: 10.1016/bs.aivir.2015.10.001

22.

Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated withdifferent herpesviruses: C. v. d. B. van Elk, M.; van Run, P.; de Jong, A.; Getu, S.; Verjans, G.; Osterhaus, A.; Kuiken, T.,
Vet Res 2016, PubMed ID: 26861818 - doi: 10.1186/s13567-016-0310-8

23.

Characterization of the immune response in ganglia after primary simian varicella virus infection:
W. J. G. Ouwendijk, S.; Mahalingam, R.; Gilden, D.; Osterhaus, A. D.; Verjans, G. M., J Neurovirol 2016,
PubMed ID: 26676825 - doi: 10.1007/s13365-015-0408-1

24.

Pathogenesis of varicelloviruses in primates: W. J. V. Ouwendijk, G. M., J Pathol 2015,
PubMed ID: 25255989 - doi: 10.1002/path.4451

25.

Detection of viral pathogens in high grade gliomas from unmapped next-generation sequencing data:
P. J. Z. Ci-mino, G.; Wang, D.; Sehn, J. K.; Lewis, J. S., Jr.; Duncavage, E. J., Exp Mol Pathol 2014,
PubMed ID: 24704430 - doi: 10.1016/j.yexmp.2014.03.010

26.

T-cell infiltration correlates with CXCL10 expression in ganglia of cynomolgus macaques with reactivated simian 		varicella virus: W. J. A. Ouwendijk, A.; Traina-Dorge, V.; Getu, S.; Steain, M.; Wellish, M.; Andeweg, A. C.;
Osterhaus, A. D.; Gilden, D.; Verjans, G. M.; Mahalingam, R., J Virol 2013,
PubMed ID: 23269790 - doi: 10.1128/jvi.03181-12

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CONTINUED

Herpes/Varicella (continued)
27.

High-Sensitivity and High-Resolution In Situ Hybridization of Coding and Long Non-coding RNAs in Vertebrate
Ova-ries and Testes: N. N. Takei, T.; Kawamura, S.; Takada, Y.; Satoh, Y.; Kimura, A. P.; Kotani, T.,
Biol Proced Online 2018, PubMed ID: 29507535 - doi: 10.1186/s12575-018-0071-z

HIV/SIV/FIV
1.

Novel Imaging Methods for Analysis of Tissue Resident Cells in HIV/SIV: E. E. Moysi, J. D.; Petrovas, C.,
Curr HIV/AIDS Rep 2016, PubMed ID: 26830285 - doi: 10.1007/s11904-016-0300-52.

Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques:
A. A. Okoye, M. Q. DeGottardi, Y. Fukazawa, M. Vaidya, C. O. Abana, A. L. Konfe, D. N. Fachko, D. M. Duell, H. Li,
R. Lum, L. Gao, B. S. Park, R. L. Skalsky, A. D. Lewis, M. K. Axthelm, J. D. Lifson, S. W. Wong and L. J. Picker,
J Immunol 2019, PubMed ID: 31653683 - doi: 10.4049/jimmunol.1900792

3.

Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence:
M. Pino, S. Paganini, C. Deleage, K. Padhan, J. L. Harper, C. T. King, L. Micci, B. Cervasi, J. C. Mudd, K. P. Gill,
S. M. Jean, K. Easley, G. Silvestri, J. D. Estes, C. Petrovas, M. M. Lederman and M. Paiardini, PLoS pathogens 2019,
PubMed ID: 31626660 - doi: 10.1371/journal.ppat.1008081

4.

TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes: M. H. Schleimann,
M. L. Kobbero, L. K. Vibholm, K. Kjaer, L. B. Giron, K. Busman-Sahay, C. N. Chan, M. Nekorchuk, M. Schmidt, B. Wittig,
T. E. Damsgaard, P. Ahlburg, M. B. Hellfritzsch, K. Zuwala, F. H. Rothemejer, R. Olesen, P. Schommers, F. Klein,
H. Dweep, A. Kossenkov, J. R. Nyengaard, J. D. Estes, M. Abdel-Mohsen, L. Ostergaard, M. Tolstrup, O. S. Sogaard 		and P. W. Denton, EBioMedicine 2019, PubMed ID: 31300344 - doi: 10.1016/j.ebiom.2019.07.005

5.

Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species: C. G. Thompson,
E. P. Rosen, H. M. A. Prince, N. White, C. Sykes, G. de la Cruz, M. Mathews, C. Deleage, J. D. Estes, P. Charlins,
L. R. Mulder, M. Kovarova, L. Adamson, S. Arora, E. S. Dellon, A. F. Peery, N. J. Shaheen, C. Gay, D. C. Muddiman,
R. Akki-na, J. Victor Garcia, P. Luciw and A. D. M. Kashuba, Sci Transl Med 2019,
PubMed ID: 31270274 - doi: 10.1126/scitranslmed.aap8758

6.

Identification of HIV transmitting CD11c(+) human epidermal dendritic cells: K. M. Bertram, R. A. Botting,
H. Bahar-lou, J. W. Rhodes, H. Rana, J. D. Graham, E. Patrick, J. Fletcher, T. M. Plasto, N. R. Truong, C. Royle,
C. M. Doyle, O. Tong, N. Nasr, L. Barnouti, M. P. Kohout, A. J. Brooks, M. P. Wines, P. Haertsch, J. Lim, M. P. Gosselink,
G. Ctercteko, J. D. Estes, M. J. Churchill, P. U. Cameron, E. Hunter, M. A. Haniffa, A. L. Cunningham and A. N. Harman,
Nat Commun 2019, PubMed ID: 31227717 - doi: 10.1038/s41467-019-10697-w

7.

Defining early SIV replication and dissemination dynamics following vaginal transmission: C. Deleage,
T. T. Immonen, C. M. Fennessey, A. Reynaldi, C. Reid, L. Newman, L. Lipkey, T. E. Schlub, C. Camus, S. O’Brien,
J. Smedley, J. M. Con-way, G. Q. Del Prete, M. P. Davenport, J. D. Lifson, J. D. Estes and B. F. Keele,
Science Advances 2019, PubMed ID: - doi: 10.1126/sciadv.aav7116

8.

CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed
Individuals: J. J. Vasquez, B. L. Aguilar-Rodriguez, L. Rodriguez, L. E. Hogan, M. Somsouk, J. M. McCune, S. G. Deeks,Z. G. Laszik, P. W. Hunt and T. J. Henrich, Pathogens and Immunity 2019, PubMed ID: - doi: 10.20411/pai.v4i1.271

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CONTINUED

HIV/SIV/FIV (continued)
9.

Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive andRefractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis: J. P. Cornish, I. N. Moore,
D. L. Perry, A. Lara, M. Minai, D. Promeneur, K. R. Hagen, K. Virtaneva, M. Paneru, C. R. Buechler, D. H. O’Connor,
A. L. Bailey, K. Cooper, S. Mazur, J. G. Bernbaum, J. Pettitt, P. B. Jahrling, J. H. Kuhn and R. F. Johnson,
Viruses 2019, PubMed ID: 30650570 - doi: 10.3390/v11010067

10.

Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate:
G. Jiang, E. Maverakis, M. Y. Cheng, M. M. Elsheikh, C. Deleage, G. Mendez-Lagares, M. Shimoda, S. A. Yukl,
D. J. Hartigan-O’Connor, G. R. Thompson, 3rd, J. D. Estes, J. K. Wong and S. Dandekar, JCI Insight 2019,
PubMed ID: 30944245 - doi: 10.1172/jci.insight.126027

11.

Immune Activations and Viral Tissue Compartmentalization During Progressive HIV-1 Infection of Humanized Mice:
H. Su, Y. Cheng, S. Sravanam, S. Mathews, S. Gorantla, L. Y. Poluektova, P. K. Dash and H. E. Gendelman,
Front Immunol 2019, PubMed ID: 30873181 - doi: 10.3389/fimmu.2019.00340

12.

Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4’-Ethynyl-2-Fluoro-2’Deoxyadenosine (EFdA)-Suppressed Humanized Mice: E. Maidji, M. E. Moreno, J. M. Rivera, P. Joshi, S. A. Galkina,
G. Kosikova, M. Somsouk and C. A. Stoddart, Viruses 2019,
PubMed ID: doi:10.3390/v11030256 - doi: 10.3390/v11030256

13.

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice:
S. Mathews, A. Branch Woods, I. Katano, E. Makarov, M. B. Thomas, H. E. Gendelman, L. Y. Poluektova, M. Ito and
S. Gorantla, Mol Neurodegener 2019, PubMed ID: 30832693 - doi: 10.1186/s13024-019-0311-y

14.

Establishment of A Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion ofPatient-Derived HIV Latent Reservoirs: N. C. Flerin, A. Bardhi, J. H. Zheng, M. Korom, J. Folkvord, C. Kovacs,
E. Benko, R. Tru-ong, T. Mota, E. Connick, R. B. Jones, R. M. Lynch and H. Goldstein, J Virol 2019,
PubMed ID: 30626677 - doi: 10.1128/jvi.02051-18

15.

Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells:O. B. P.-C. Ukah, M.; Tedbury, P. R.; Herschhorn, A.; Sodroski, J. G.; Sarafianos, S. G., Viruses 2018,
PubMed ID: 30274333 - doi: 10.3390/v10100534

16.

Characterization of inducible transcription and translation-competent HIV-1 using the RNAscope ISH technology
at a single-cell resolution: W. Z. S. S. A. A. S. U. Neogi, Front. Microbiol. 2018,
PubMed ID: - doi: 10.3389/fmicb.2018.02358

17.

Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanizedmouse model: J. K. Samal, S.; Na-Shatal, A.; Elhakiem, A.; Das, A.; Ding, M.; Sanyal, A.; Gupta, P.; Melody, K.;
Roland, B.; Ahmed, W.; Zakir, A.; Bility, M., JCI Insight 2018, PubMed ID: 30232273 - doi: 10.1172/jci.insight.120430

18.

Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates:
R. B.-C. Sivanandham, E.; Krampe, N.; Falwell, E.; Kilapandal Venkatraman, S. M.; Ribeiro, R. M.; Apetrei, C.;
Pandrea, I., J Clin Invest 2018, PubMed ID: 30204591 - doi: 10.1172/jci99420

19.

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on
Suppressive Antiretroviral Therapy: A. K. Ko, G.; Hattler, J. B.; Galadima, H. I.; Zhang, J.; Li, Q.; Kim, W. K.,
J Neuroimmune Pharmacol 2018, PubMed ID: 30194646 - doi: 10.1007/s11481-018-9809-2

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CONTINUED

HIV/SIV/FIV (continued)
20.

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration: V. P. Achuthan, Jill M.;
Sowd, Gregory A.; Puray-Chavez, Maritza; McDougall, William M.; Paulucci-Holthauzen, Adriana; Wu, Xiaolin;
Fadel, Hind J.; Poeschla, Eric M.; Multani, Asha S.; Hughes, Stephen H.; Sarafianos, Stefan G.; Brass, Abraham L.;
Engelman, Alan N., Cell Host & Microbe 2018, PubMed ID: - doi: https://doi.org/10.1016/j.chom.2018.08.002

21.

Brain is a potential sanctuary for subtype C HIV-1 irrespective of ART treatment outcome: F. Y. K. Tso, G.; Kwon, E. H.;
Julius, P.; Li, Q.; West, J. T.; Wood, C., PLoS One 2018, PubMed ID: 30040863 - doi: 10.1371/journal.pone.0201325

22.

SIV persistence in cellular and anatomic reservoirs in ART-suppressed infant rhesus macaques: M. H. Mavigner, J.;
Deleage, C.; Rosen, E.; Mattingly, C.; Bricker, K.; Kashuba, A.; Amblard, F.; Schinazi, R. F.; Jean, S.; Cohen, J.;
McGary, C.; Paiardini, M.; Wood, M. P.; Sodora, D. L.; Silvestri, G.; Estes, J.; Chahroudi, A., J Virol 2018,
PubMed ID: 29997216 - doi: 10.1128/jvi.00562-18

23.

Multiple, Independent T Cell Lymphomas Arising in an Experimentally FIV-Infected Cat during the Terminal Stageof Infection: B. G. E. Murphy, C.; Castillo, D.; Poon, A.; Liepnieks, M.; Harmon, K.; Moore, P., Viruses 2018,
PubMed ID: 29794987 - doi: 10.3390/v10060280

24.

Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal
Macrophage Infection: F. S. Real, A.; Ganor, Y.; Schmitt, A.; Bomsel, M., Cell Rep 2018,
PubMed ID: 29742434 - doi: 10.1016/j.celrep.2018.04.028

25.

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV
gene therapy: C. W. W. Peterson, J.; Deleage, C.; Reddy, S.; Kaur, J.; Polacino, P.; Reik, A.; Huang, M. L.;
Jerome, K. R.; Hu, S. L.; Holmes, M. C.; Estes, J. D.; Kiem, H. P., PLoS Pathog 2018,
PubMed ID: 29672640 - doi: 10.1371/journal.ppat.1006956

26.

Accumulation of follicular CD8+ T cells in pathogenic SIV infection: S. M. Ferrando-Martinez, E.; Pegu, A.;
Andrews, S.; Nganou Makamdop, K.; Ambrozak, D.; McDermott, A. B.; Palesch, D.; Paiardini, M.; Pavlakis, G. N.; 		
Brenchley, J. M.; Douek, D.; Mascola, J. R.; Petrovas, C.; Koup, R. A., J Clin Invest 2018,
PubMed ID: 29664020 - doi: 10.1172/jci96207

27.

Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency
Virus Infection in Rhesus Macaques: D. C. S. Hsu, P.; Wegner, M.; Schuetz, A.; Silsorn, D.; Estes, J. D.; Deleage, C.;
Tomusange, K.; Lakhashe, S. K.; Ruprecht, R. M.; Lombardini, E.; Im-Erbsin, R.; Kuncharin, Y.; Phuang-Ngern, Y.; 		
Inthawong, D.; Chuenarom, W.; Burke, R.; Robb, M. L.; Ndhlovu, L. C.; Ananworanich, J.; Valcour, V.; O’Connell, R. J.;
Spudich, S.; Michael, N. L.; Vasan, S., J Virol 2018, PubMed ID: 29563297 - doi: 10.1128/jvi.00222-18

28.

Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells
expressing CD30: L. E. V. Hogan, J.; Hobbs, K. S.; Hanhauser, E.; Aguilar-Rodriguez, B.; Hussien, R.; Thanh, C.;
Gibson, E. A.; Carvidi, A. B.; Smith, L. C. B.; Khan, S.; Trapecar, M.; Sanjabi, S.; Somsouk, M.; Stoddart, C. A.;
Kuritzkes, D. R.; Deeks, S. G.; Henrich, T. J., PLoS Pathog 2018,
PubMed ID: 29470552 - doi: 10.1371/journal.ppat.1006856

29.

Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization:
Meth-ods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ: J. J. H. Vasquez, R.;
Aguilar-Rodriguez, B.; Junger, H.; Dobi, D.; Henrich, T. J.; Thanh, C.; Gibson, E.; Hogan, L. E.; McCune, J.;
Hunt, P. W.; Stoddart, C. A.; Laszik, Z. G., J Histochem Cytochem 2018,
PubMed ID: 29462571 - doi: 10.1369/0022155418756848

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CONTINUED

HIV/SIV/FIV (continued)
30.

Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART:
B. S. G. Fisher, R. R.; Brown, R. R.; Wood, M. P.; Hensley-McBain, T.; Fisher, C.; Chang, J.; Miller, A. D.; Bosche, W. J.;
Lifson, J. D.; Mavigner, M.; Miller, C. J.; Gale, M., Jr.; Silvestri, G.; Chahroudi, A.; Klatt, N. R.; Sodora, D. L.,
PLoS Pathog 2018, PubMed ID: 29466439 - doi: 10.1371/journal.ppat.1006871

31.

Creation of a long-acting nanoformulated dolutegravir: B. B. Sillman, A. N.; Dash, P. K.; Bhargavan, B.; Kocher, T.; 		
Mathews, S.; Su, H.; Kanmogne, G. D.; Poluektova, L. Y.; Gorantla, S.; McMillan, J.; Gautam, N.; Alnouti, Y.;
Edagwa, B.; Gendelman, H. E., Nat Commun 2018, PubMed ID: 29402886 - doi: 10.1038/s41467-018-02885-x

32.

Acute Appendicitis as the Initial Clinical Presentation of Primary HIV-1 Infection: M. H. L. Schleimann, Steffen;
Krarup, Astrid R.; Mortensen, Jesper; Barstad, Bente; Zaccarin, Matthias; Denton, Paul W.; Mohey, Rajesh,
Open Forum Infectious Diseases 2018, PubMed ID: - doi: 10.1093/ofid/ofy006

33.

Increased Microglial CSF1R Expression in the SIV/Macaque Model of HIV CNS Disease: A. C. B. Knight, S. A.;
Queen, S. E.; Tarwater, P. M.; Mankowski, J. L., J Neuropathol Exp Neurol 2018,
PubMed ID: 29319809 - doi: 10.1093/jnen/nlx115

34.

Next-generation in situ hybridization approaches to define and quantify HIV and SIV reservoirs in tissue
microenvironments: C. C. Deleage, C. N.; Busman-Sahay, K.; Estes, J. D., Retrovirology 2018,
PubMed ID: 29316956 - doi: 10.1186/s12977-017-0387-9

35.

The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles:
G. M. L. Webb, Shengbin; Mwakalundwa, Gwantwa; Folkvord, Joy M.; Greene, Justin M.; Reed, Jason S.;
Stanton, Jeffery J.; Legasse, Alfred W.; Hobbs, Theodore; Martin, Lauren D.; Park, Byung S.; Whitney, James B.;
Jeng, Emily K.; Wong, Hing C.; Nixon, Douglas F.; Jones, R. Brad; Connick, Elizabeth; Skinner, Pamela J.;
Sacha, Jonah B., Blood Advances 2018, PubMed ID: - doi: 10.1182/bloodadvances.2017012971

36.

Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus-Infected Macaques
Receiving Antiretroviral Therapy: L. M. B. Mangus, Sarah E.; Queen, Suzanne E.; Brill, Samuel A.; Shirk, Erin N.;
Metcalf Pate, Kelly A.; Muth, Dillon C.; Adams, Robert J.; Gama, Lucio; Clements, Janice E.; Mankowski, Joseph L.,
The American Journal of Pathology 2017, PubMed ID: - doi: 10.1016/j.ajpath.2017.08.035

37.

Multiplex single-cell visualization of nucleic acids and protein during HIV infection: M. T. Puray-Chavez, P. R.;
Huber, A. D.; Ukah, O. B.; Yapo, V.; Liu, D.; Ji, J.; Wolf, J. J.; Engelman, A. N.; Sarafianos, S. G., Nat Commun 2017, 		
PubMed ID: 29192235 - doi: 10.1038/s41467-017-01693-z

38.

CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed,
SIV-Infected Rhesus Macaques: C. S. D. McGary, C.; Harper, J.; Micci, L.; Ribeiro, S. P.; Paganini, S.;
Kuri-Cervantes, L.; Benne, C.; Ryan, E. S.; Balderas, R.; Jean, S.; Easley, K.; Marconi, V.; Silvestri, G.; Estes, J. D.;
Sekaly, R. P.; Paiardini, M., Immunity 2017, PubMed ID: 29045906 - doi: 10.1016/j.immuni.2017.09.018

39.

CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute
SHIV infection: D. C. W. Hsu, M. D.; Sunyakumthorn, P.; Silsorn, D.; Tayamun, S.; Inthawong, D.; Kuncharin, Y.;
Im-Erbsin, R.; Ege, C.; O’Connell, R. J.; Michael, N. L.; Ndhlovu, L. C.; Vasan, S., J Med Primatol 2017,
PubMed ID: 28748665 - doi: 10.1111/jmp.12298

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CONTINUED

HIV/SIV/FIV (continued)
40.

Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells: M. B. Cavrois, Trambak;
Mukherjee, Gourab; Raman, Nandhini; Hussien, Rajaa; Rodriguez, Brandon Aguilar; Vasquez, Joshua;
Spitzer, Mat-thew H.; Lazarus, Nicole H.; Jones, Jennifer J.; Ochsenbauer, Christina; McCune, Joseph M.;
Butcher, Eugene C.; Arv-in, Ann M.; Sen, Nandini; Greene, Warner C.; Roan, Nadia R., Cell Reports 2017,
PubMed ID: 28746881 - doi: 10.1016/j.celrep.2017.06.087

41.

Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants:
A. B. Introini, S.; Bradley, F.; Gibbs, A.; Glaessgen, A.; Tjernlund, A.; Broliden, K., PLoS Pathog 2017,
PubMed ID: 28542587 - doi: 10.1371/journal.ppat.1006402

42.

Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4<sup>+</sup> T Cells in African Green
Monkeys: C. L. O. Vinton, Alexandra M.; Calantone, Nina; Mudd, Joseph C.; Deleage, Claire; Morcock, David R.; 		
Whitted, Sonya; Estes, Jacob D.; Hirsch, Vanessa M.; Brenchley, Jason M., The Journal of Immunology 2017,
PubMed ID: - doi: 10.4049/jimmunol.1700136

43.

Peripheral and central immune cell reservoirs in tissues from asymptomatic cats chronically infected with feline
immunodeficiency virus: C. D. S. Eckstrand, E. E.; Pitt, K. A.; Murphy, B. G., PLoS One 2017,
PubMed ID: 28384338 - doi: 10.1371/journal.pone.0175327

44.

CXCR5 Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved Through T-Cell Engineering:
V. I. D. Ayala, C.; Trivett, M. T.; Jain, S.; Coren, L. V.; Breed, M. W.; Kramer, J. A.; Thomas, J. A.; Estes, J. D.; Lifson, J. D.;
Ott, D. E., J Virol 2017, PubMed ID: 28298605 - doi: 10.1128/jvi.02507-16

45.

Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction: E. S. Maidji, M.;
Rivera, J. M.; Hunt, P. W.; Stoddart, C. A., PLoS Pathog 2017, PubMed ID: 28241080 - doi: 10.1371/journal.ppat.1006202

46.

Controlling multi-cycle replication of live-attenuated HIV-1 using an unnatural genetic switch: Z. W. Yuan, N.;
Kang, G.; Niu, W.; Li, Q.; Guo, J., ACS Synth Biol 2017, PubMed ID: 28106981 - doi: 10.1021/acssynbio.6b00373

47.

Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques:
L. A. Gama, C. M.; Shirk, E. N.; Price, S. L.; Li, M.; Laird, G. M.; Pate, K. A.; Wietgrefe, S. W.; O’Connor, S. L.;
Pianowski, L.; Haase, A. T.; Van Lint, C.; Siliciano, R. F.; Clements, J. E., Aids 2017,
PubMed ID: 27898590 - doi: 10.1097/qad.0000000000001267

48.

Programed death-1/programed death-ligand 1 expression in lymph nodes of HIV infected patients: results of apilot safety study in rhesus macaques using anti-programed death-ligand 1 (Avelumab): A. L. G. Gill, S. A.;
Abdullah, S.; Le Saout, C.; Pittaluga, S.; Chen, H.; Turnier, R.; Lifson, J.; Godin, S.; Qin, J.; Sneller, M. C.;
Cuillerot, J. M.; Sabzevari, H.; Lane, H. C.; Catalfamo, M., Aids 2016,
PubMed ID: 27490642 - doi: 10.1097/qad.0000000000001217

49.

CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with
Short-Term Antiretroviral Therapy: E. K. S. Cartwright, L.; Smith, S. A.; Lee, D.; Fast, R.; Paganini, S.; Lawson, B. O.; 		
Nega, M.; Easley, K.; Schmitz, J. E.; Bosinger, S. E.; Paiardini, M.; Chahroudi, A.; Vanderford, T. H.; Estes, J. D.;
Lifson, J. D.; Der-deyn, C. A.; Silvestri, G., Immunity 2016,
PubMed ID: 27653601 - doi: 10.1016/j.immuni.2016.08.018

50.

CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles: Y. A. C. Leong, Y.; Ong, H. S.; Wu, D.;
Man, K.; Deleage, C.; Minnich, M.; Meckiff, B. J.; Wei, Y.; Hou, Z.; Zotos, D.; Fenix, K. A.; Atnerkar, A.; Preston, S.; 		
Chipman, J. G.; Beilman, G. J.; Allison, C. C.; Sun, L.; Wang, P.; Xu, J.; Toe, J. G.; Lu, H. K.; Tao, Y.; Palendira, U.;
Dent, A. L.; Landay, A. L.; Pellegrini, M.; Comerford, I.; McColl, S. R.; Schacker, T. W.; Long, H. M.; Estes, J. D.;
Busslinger, M.; Belz, G. T.; Lewin, S. R.; Kallies, A.; Yu, D., Nat Immunol 2016,
PubMed ID: 27487330 - doi: 10.1038/ni.3543
Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUED

HIV/SIV/FIV (continued)
51.

Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence:
C. T. Deleage, B.; Estes, J. D., Curr Opin Virol 2016, PubMed ID: 27490446 - doi: 10.1016/j.coviro.2016.07.002

52.

HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined
Antiretroviral Therapy in Individuals with Cancer: R. L. Rose, S. L.; Nolan, D. J.; Maidji, E.; Faria, N. R.; Pybus, O. G.;
Dollar, J. J.; Maruniak, S. A.; McAvoy, A. C.; Salemi, M.; Stoddart, C. A.; Singer, E. J.; McGrath, M. S.,
J Virol 2016, PubMed ID: 27466425 - doi: 10.1128/jvi.00684-16

53.

Defining HIV and SIV Reservoirs in Lymphoid Tissues: C. W. Deleage, S. W.; Del Prete, G.; Morcock, D. R.; Hao, X. P.;
Piatak, M., Jr.; Bess, J.; Anderson, J. L.; Perkey, K. E.; Reilly, C.; McCune, J. M.; Haase, A. T.; Lifson, J. D.;
Schacker, T. W.; Estes, J. D., Pathog Immun 2016, PubMed ID: 27430032 - doi: 10.20411/pai.v1i1.100

54.

Inhibition of Heat Shock Protein 90 Prevents HIV Rebound: P. M. Joshi, E.; Stoddart, C. A., J Biol Chem 2016,
Pub-Med ID: 26957545 - doi: 10.1074/jbc.M116.717538

55.

Macrophages sustain HIV replication in vivo independently of T cells: J. B. W. Honeycutt, A.; Baker, C.;
Spagnuolo, R. A.; Foster, J.; Zakharova, O.; Wietgrefe, S.; Caro-Vegas, C.; Madden, V.; Sharpe, G.; Haase, A. T.;
Eron, J. J.; Garcia, J. V., J Clin Invest 2016, PubMed ID: 26950420 - doi: 10.1172/jci84456

56.

Lymphatic Dissemination of Simian Immunodeficiency Virus after Penile Inoculation: Z. M. D. Ma, J.; Fritts, L.;
Miller, C. J., J Virol 2016, PubMed ID: 26865706 - doi: 10.1128/jvi.02947-15

57.

The meningeal lymphatic system: a route for HIV brain migration?: S. L. R. Lamers, R.; Ndhlovu, L. C.;
Nolan, D. J.; Salemi, M.; Maidji, E.; Stoddart, C. A.; McGrath, M. S., J Neurovirol 2016,
PubMed ID: 26572785 - doi: 10.1007/s13365-015-0399-y

58.

CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnoverof infected cells: L. A. Micci, X.; Iriele, R. I.; Ortiz, A. M.; Ryan, E. S.; McGary, C. S.; Deleage, C.; McAtee, B. B.; He, T.;
Apetrei, C.; Easley, K.; Pahwa, S.; Collman, R. G.; Derdeyn, C. A.; Davenport, M. P.; Estes, J. D.; Silvestri, G.;
Lackner, A. A.; Paiardini, M., PLoS Pathog 2014, PubMed ID: 25356757 - doi: 10.1371/journal.ppat.1004467

59.

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers:
Y. L. Fukazawa, R.; Okoye, A. A.; Park, H.; Matsuda, K.; Bae, J. Y.; Hagen, S. I.; Shoemaker, R.; Deleage, C.; Lucero, C.;
Morcock, D.; Swanson, T.; Legasse, A. W.; Axthelm, M. K.; Hesselgesser, J.; Geleziunas, R.; Hirsch, V. M.; Edlefsen, P. T.;
Piatak, M., Jr.; Estes, J. D.; Lifson, J. D.; Picker, L. J., Nat Med 2015, PubMed ID: 25599132 - doi: 10.1038/nm.3781

60.

Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model ofcombination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques:
G. Q. S. Del Prete, R.; Oswald, K.; Lara, A.; Trubey, C. M.; Fast, R.; Schneider, D. K.; Kiser, R.; Coalter, V.; Wiles, A.; 		
Wiles, R.; Freemire, B.; Keele, B. F.; Estes, J. D.; Quinones, O. A.; Smedley, J.; Macallister, R.; Sanchez, R. I.; Wai, J. S.;
Tan, C. M.; Alvord, W. G.; Hazuda, D. J.; Piatak, M., Jr.; Lifson, J. D., Antimicrob Agents Chemother 2014,
PubMed ID: 25182644 - doi: 10.1128/aac.03746-14

62.

Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in
nonhuman primate models of HIV transmission: J. T. Smedley, B.; Bernardo, M. L.; Del Prete, G. Q.; Estes, J. D.;
Griffiths, G. L.; Kobayashi, H.; Choyke, P. L.; Lifson, J. D.; Keele, B. F., PLoS One 2014,
PubMed ID: 24667371 - doi: 10.1371/journal.pone.0092830

63.

Detection of low abundance RNA molecules in individual cells by flow cytometry: M. B. L. Hanley, W.; Mittar, D.;
Maino, V.; Park, E., PLoS One 2013, PubMed ID: 23441230 - doi: 10.1371/journal.pone.0057002

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUED

Parvovirus
1.

Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys:
Q. Lee, M. P. Padula, N. Pinello, S. H. Williams, M. B. O’Rourke, M. J. Fumagalli, J. D. Orkin, R. Song, B. Shaban,
O. Brenner, J. E. Pimanda, W. Weninger, W. M. Souza, A. D. Melin, J. J. Wong, M. J. Crim, S. Monette, B. Roediger and
C. J. Jolly, PLoS Pathog 2020, PubMed ID: 31971979 - doi: 10.1371/journal.ppat.1008262

2.

An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis: B. L. Roediger, Quintin;
Tikoo, Shweta; Cobbin, Joanna C. A.; Henderson, James M.; Jormakka, Mika; O’Rourke, Matthew B.;
Padula, Matthew P.; Pinello, Natalia; Henry, Marisa; Wynne, Maria; Santagostino, Sara F.; Brayton, Cory F.;
Rasmussen, Lorna; Lisowski, Leszek; Tay, Szun S.; Harris, David C.; Bertram, John F.; Dowling, John P.;
Bertolino, Patrick; Lai, Jack H.; Wu, Wengen; Bachovchin, William W.; Wong, Justin J. L.; Gorrell, Mark D.;
Shaban, Babak; Holmes, Edward C.; Jolly, Christopher J.; Monette, Sébastien; Weninger, Wolfgang, Cell 2018, 		
PubMed ID: - doi: https://doi.org/10.1016/j.cell.2018.08.013

3.

Amdoparvovirus Infection in Red Pandas (Ailurus fulgens): C. E. K. Alex, S. V.; Li, L.; Sadeghi, M.;
Wack, R. F.; McCar-thy, M. A.; Pesavento, J. B.; Delwart, E.; Pesavento, P. A., Vet Pathol 2018,
PubMed ID: 29433401 - doi: 10.1177/0300985818758470

4.

Parvovirus Infection Is Associated With Myocarditis and Myocardial Fibrosis in Young Dogs: J. M. Ford, L.;
Renshaw, R.; Molesan, A.; Kelly, K., Vet Pathol 2017, PubMed ID: 28812526 - doi: 10.1177/0300985817725387

5.

Feline Panleukopenia Virus Is Not Associated with Myocarditis or Endomyocardial Restrictive Cardiomyopathy
in Cats: L. M. A. M. H. E. K. Kelly, Veterinary Pathology 2017, PubMed ID: - doi: doi:10.1177/0300985817695516

6.

A new protoparvovirus in human fecal samples and cutaneous T cell lymphomas (mycosis fungoides):T. G. D. Phan, B.; da Costa, A. C.; Li, L.; Orlandi, P.; Deng, X.; Kapusinszky, B.; Siqueira, J.; Knol, A. C.; Halary, F.; 		
Dantal, J.; Alexander, K. A.; Pesavento, P. A.; Delwart, E., Virology 2016,
PubMed ID: 27393975 - doi: 10.1016/j.virol.2016.06.013

7.

Novel B19-like parvovirus in the brain of a harbor seal: R. R. G. Bodewes, A.; Wiersma, L. C.; Getu, S.; Beukers, M.;
Schapendonk, C. M.; van Run, P. R.; van de Bildt, M. W.; Poen, M. J.; Osinga, N.; Sanchez Contreras, G. J.; Kuiken, T.;
Smits, S. L.; Osterhaus, A. D., PLoS One 2013, PubMed ID: 24223918 - doi: 10.1371/journal.pone.0079259

Other Viruses
1.

Dysregulation of TNF-alpha and IFN-gamma expression is a common host immune response in a chronicallyinfected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei:
K. Amemiya, J. L. Dankmeyer, J. J. Bearss, X. Zeng, S. W. Stonier, C. Soffler, C. K. Cote, S. L. Welkos,
D. P. Fetterer, T. B. Chance, S. R. Trevino, P. L. Worsham and D. M. Waag, BMC Immunol 2020,
PubMed ID: 32013893 - doi: 10.1186/s12865-020-0333-9

2.

Vaccination with Ectoparasite Proteins Involved in Midgut Function and Blood Digestion Reduces Salmon
Louse Infestations: M. Contreras, M. Karlsen, M. Villar, R. H. Olsen, L. M. Leknes, A. Furevik, K. L. Yttredal,
H. Tartor, S. Grove, P. Alberdi, B. Brudeseth and J. de la Fuente, Vaccines (Basel) 2020,
PubMed ID: 31963779 - doi: 10.3390/vaccines8010032

3.

Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment:
W. Wang, A. Uberoi, M. Spurgeon, E. Gronski, V. Majerciak, A. Lobanov, M. Hayes, A. Loke, Z. M. Zheng and
P. F. Lambert, PLoS Pathog 2020, PubMed ID: 31968015 - doi: 10.1371/journal.ppat.1008206

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CONTINUED

Other Viruses (continued)
4.

A dual role for hepatocyte-intrinsic canonical NF-kappaB signaling in virus control: S. Namineni, T. O’Connor,
S. Faure-Dupuy, P. Johansen, T. Riedl, K. Liu, H. Xu, I. Singh, P. Shinde, F. Li, A. Pandyra, P. Sharma, M. Ringelhan,
A. Muschaweckh, K. Borst, P. Blank, S. Lampl, D. Durantel, R. Farhat, A. Weber, D. Lenggenhager, T. M. Kundig,
P. Stae-heli, U. Protzer, D. Wohlleber, B. Holzmann, M. Binder, K. Breuhahn, L. M. Assmus, J. Nattermann, Z. Abdullah,
M. Rolland, E. Dejardin, P. A. Lang, K. S. Lang, M. Karin, J. Lucifora, U. Kalinke, P. A. Knolle and M. Heikenwalder,
J Hepatol 2020, PubMed ID: 31954207 - doi: 10.1016/j.jhep.2019.12.019

5.

Genomic Characterization of a Novel Circovirus from a Stranded Longman’s Beaked whale (Indopacetus pacificus):
N. Landrau-Giovannetti, K. Subramaniam, M. A. Brown, T. F. Fan Ng, D. S. Rotstein, K. West, S. Frasca andT. B. Waltzek, Virus Research 2019, PubMed ID: - doi: https://doi.org/10.1016/j.virusres.2019.197826

6.

The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediatedpriming of type III interferon: K. R. Grau, S. Zhu, S. T. Peterson, E. W. Helm, D. Philip, M. Phillips, A. Hernandez,
H. Tu-rula, P. Frasse, V. R. Graziano, C. B. Wilen, C. E. Wobus, M. T. Baldridge and S. M. Karst,
Nature Microbiology 2019, PubMed ID: - doi: 10.1038/s41564-019-0602-7

7.

CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung: C. S. Anderson, C.-Y. Chu, Q. Wang,
J. A. Mereness, Y. Ren, K. Donlon, S. Bhattacharya, R. S. Misra, E. E. Walsh, G. S. Pryhuber and T. J. Mariani,
Pediatric research 2019, PubMed ID: 31726465 - doi: 10.1038/s41390-019-0677-0

8.

Detection and Cellular Tropism of Porcine Astrovirus Type 3 on Breeding Farms:
G. Rawal, F. Matias Ferreyra, R. M. N, K. B. L, M. H. K, A. Mueller, G. Allison, C. L. L. D and L. A. B, Viruses 2019,
PubMed ID: 31718108 - doi: 10.3390/v11111051

9.

Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus: M. E. Spurgeon and P. F. Lambert,
eLife 2019, PubMed ID: 31621578 - doi: 10.7554/eLife.50056

10.

Design and characterization of a consensus hemagglutinin vaccine immunogen against H3 influenza A virusesof swine: H. Sun, J.-H. Sur, S. Sillman, D. Steffen and H. L. X. Vu, Veterinary Microbiology 2019,
PubMed ID: - doi: https://doi.org/10.1016/j.vetmic.2019.108451

11.

The neuropathology of fatal encephalomyelitis in human Borna virus infection: F. Liesche, V. Ruf, S. Zoubaa,
G. Kaletka, M. Rosati, D. Rubbenstroth, C. Herden, L. Goehring, S. Wunderlich, M. F. Wachter, G. Rieder,
I. Lichtman-negger, W. Permanetter, J. G. Heckmann, K. Angstwurm, B. Neumann, B. Markl, S. Haschka, H. H. Niller,
B. Schmidt, J. Jantsch, C. Brochhausen, K. Schlottau, A. Ebinger, B. Hemmer, M. J. Riemenschneider, J. Herms,
M. Beer, K. Mati-asek and J. Schlegel, Acta Neuropathol 2019, PubMed ID: 31346692 - doi: 10.1007/s00401-019-02047-3

12.

Persistent Crimean-Congo hemorrhagic fever virus infection in the testes and within granulomas of non-humanprimates with latent tuberculosis: D. R. Smith, C. J. Shoemaker, X. Zeng, A. R. Garrison, J. W. Golden,
C. W. Schellhase, W. Pratt, F. Rossi, C. J. Fitzpatrick, J. Shamblin, A. Kimmel, J. Zelko, O. Flusin, J. W. Koehler, J. Liu,
K. M. Coffin, K. M. Ricks, M. A. Voorhees, R. J. Schoepp and C. S. Schmaljohn, PLoS Pathog 2019,
PubMed ID: 31557262 - doi: 10.1371/journal.ppat.1008050

13.

Differentiating Batrachochytrium dendrobatidis and B. salamandrivorans in Amphibian Chytridiomycosis Using
RNAScope in situ Hybridization: R. J. Ossiboff, A. E. Towe, M. A. Brown, A. V. Longo, K. R. Lips, D. L. Miller,
E. D. Carter, M. J. Gray and S. Frasca, Jr., Front Vet Sci 2019, PubMed ID: 31572738 - doi: 10.3389/fvets.2019.00304

14.

Characteristics of subclinical Mycobacterium avium ssp. paratuberculosis infection in a captive white-tailed
deer herd: M. V. Palmer, C. Kanipe, R. Cox, S. Robbe-Austerman and T. C. Thacker, J Vet Diagn Invest 2019,
PubMed ID: 31510911 - doi: 10.1177/1040638719873028

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CONTINUED

Other Viruses (continued)
15.

Bat influenza viruses transmit among bats but are poorly adapted to non-bat species: K. Ciminski, W. Ran, M. Gorka,
J. Lee, A. Malmlov, J. Schinkothe, M. Eckley, R. A. Murrieta, T. A. Aboellail, C. L. Campbell, G. D. Ebel, J. Ma,
A. Pohl-mann, K. Franzke, R. Ulrich, D. Hoffmann, A. Garcia-Sastre, W. Ma, T. Schountz, M. Beer and M. Schwemmle,
Nat Mi-crobiol 2019, PubMed ID: 31527796 - doi: 10.1038/s41564-019-0556-9

16.

Erythroid Progenitor Cells in Atlantic Salmon (Salmo salar) May Be Persistently and Productively Infected with
Piscine Orthoreovirus (PRV): M. S. Malik, H. Bjorgen, K. Dhamotharan, O. Wessel, E. O. Koppang, E. Di Cicco,
E. F. Han-sen, M. K. Dahle and E. Rimstad, Viruses 2019, PubMed ID: 31491892 - doi: 10.3390/v11090824

17.

Persistent infection and transmission of Senecavirus A from carrier sows to contact piglets: M. F. Maggioli,
M. H. V. Fernandes, L. R. Joshi, B. Sharma, M. M. Tweet, J. C. G. Noll, F. V. Bauermann and D. G. Diel, J Virol 2019, 		
PubMed ID: 31434730 - doi: 10.1128/jvi.00819-19h

18.

Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila:
R. Zhang, J. T. Earnest, A. S. Kim, E. S. Winkler, P. Desai, L. J. Adams, G. Hu, C. Bullock, B. Gold, S. Cherry and
M. S. Diamond, Cell Rep 2019, PubMed ID: 31484075 - doi: 10.1016/j.celrep.2019.07.105

19.

Endangered wild salmon infected by newly discovered viruses: G. J. Mordecai, K. M. Miller, E. Di Cicco,
A. D. Schulze, K. H. Kaukinen, T. J. Ming, S. Li, A. Tabata, A. Teffer, D. A. Patterson, H. W. Ferguson and C. A. Suttle,
Elife 2019, PubMed ID: 31478480 - doi: 10.7554/eLife.47615

20.

Establishment of an RNA polymerase II-driven reverse genetics system for Nipah virus strains from Malaysia
and Bangladesh: B. D. Griffin, A. Leung, M. Chan, B. M. Warner, C. Ranadheera, K. Tierney, J. Audet, K. L. Frost,
D. Safronetz, C. Embury-Hyatt, S. A. Booth and D. Kobasa, Sci Rep 2019,
PubMed ID: 31371748 - doi: 10.1038/s41598-019-47549-y21.

Nipah virus persists in the brains of nonhuman primate survivors: J. Liu, K. M. Coffin, S. C. Johnston, A. M. Babka,
T. M. Bell, S. Y. Long, A. N. Honko, J. H. Kuhn and X. Zeng, JCI Insight 2019,
PubMed ID: 31341108 - doi: 10.1172/jci.insight.129629

22.

A vaccine based on recombinant modified Vaccinia Ankara containing the nucleoprotein from Lassa virus protects
against disease progression in a guinea pig model: E. M. Kennedy, S. D. Dowall, F. J. Salguero, P. Yeates, M. Aram 		and R. Hewson, Vaccine 2019, PubMed ID: 31331770 - doi: 10.1016/j.vaccine.2019.07.023

23.

Application of RNAscope technology to studying the infection dynamics of a Chinese porcine epidemic diarrhea
virus variant strain BJ2011C in neonatal piglets: Y. Cai, D. Wang, L. Zhou, X. Ge, X. Guo, J. Han and H. Yang,
Veterinary Microbiology 2019, PubMed ID: - doi: https://doi.org/10.1016/j.vetmic.2019.07.003

24.

Multi-tool diagnosis of an outbreak of ranavirosis in amphibian tadpoles in the Canadian boreal forest: M. J. Forzan,
J. Bienentreu, D. M. Schock and D. Lesbarreres, Dis Aquat Organ 2019,
PubMed ID: 31219433 - doi: 10.3354/dao03369

25.

Therapeutic efficacy of favipiravir against Bourbon virus in mice: T. L. Bricker, M. Shafiuddin, A. P. Gounder, A. B.
Janowski, G. Zhao, G. D. Williams, B. W. Jagger, M. S. Diamond, T. Bailey, J. H. Kwon, D. Wang and A. C. M. Boon,
PLoS Pathog 2019, PubMed ID: 31194854 - doi: 10.1371/journal.ppat.1007790

26.

PCV3-associated disease in the United States swine herd: B. Arruda, P. Pineyro, R. Derscheid, B. Hause, E. Byers,
K. Dion, D. Long, C. Sievers, J. Tangen, T. Williams and K. Schwartz, Emerg Microbes Infect 2019,
PubMed ID: 31096848 - doi: 10.1080/22221751.2019.1613176

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CONTINUED

Other Viruses (continued)
27.

The first reptilian circovirus identified infects gut and liver tissues of black-headed pythons: E. Altan, S. V. Kubiski,
J. Burchell, E. Bicknese, X. Deng and E. Delwart, Vet Res 2019,
PubMed ID: 31097029 - doi: 10.1186/s13567-019-0653-z

28.

Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced
allergic dis-ease: C. A. Malinczak, W. Fonseca, A. J. Rasky, C. Ptaschinski, S. Morris, S. F. Ziegler and N. W. Lukacs, 		Mucosal Immunol 2019, PubMed ID: 31076663 - doi: 10.1038/s41385-019-0171-3

29.

Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscineorthoreo-virus (PRV): H. Bjorgen, R. Haldorsen, O. Oaland, A. Kvellestad, D. Kannimuthu, E. Rimstad andE. O. Koppang, J Fish Dis 2019, PubMed ID: 30972792 - doi: 10.1111/jfd.12995

30.

In situ hybridization assay for the diagnosis of chagas myocarditis and orchitis in a rhesus macaque(Macaca mulatta): A case report: M. DeLorenzo, E. Carias, A. Mustonen, O. Gonzalez, E. J. Dick, Jr. and S. Kumar,
J Med Primatol 2019, PubMed ID: 30912150 - doi: 10.1111/jmp.12406

31.

Pathogenicity of Nipah henipavirus Bangladesh in a swine host: S. B. Kasloff, A. Leung, B. S. Pickering, G. Smith, 		E. Moffat, B. Collignon, C. Embury-Hyatt, D. Kobasa and H. M. Weingartl, Sci Rep 2019,
PubMed ID: 30914663 - doi: 10.1038/s41598-019-40476-y

32.

Novel Picornavirus in Lambs with Severe Encephalomyelitis: L. F. Forth, S. F. E. Scholes, P. A. Pesavento, K. Jackson,
A. Mackintosh, A. Carson, F. Howie, K. Schlottau, K. Wernike, A. Pohlmann, D. Höper and M. Beer,
Emerging Infectious Diseases 2019, PubMed ID: - doi: 10.3201/eid2505.181573

33.

Early Pulmonary Lesions in Cattle Infected via Aerosolized Mycobacterium bovis: M. V. Palmer, J. Wiarda, C. Kanipe
and T. C. Thacker, Vet Pathol 2019, PubMed ID: 30895908 - doi: 10.1177/0300985819833454

34.

Common midwife toad ranaviruses replicate first in the oral cavity of smooth newts (Lissotriton vulgaris) and show
distinct strain-associated pathogenicity: B. Saucedo, T. W. J. Garner, N. Kruithof, S. J. R. Allain, M. J. Goodman,
R. J. Cranfield, C. Sergeant, D. A. Vergara, M. J. L. Kik, M. J. Forzán, S. J. van Beurden and A. Gröne,
Scientific Reports 2019, PubMed ID: - doi: 10.1038/s41598-019-41214-0

35.

Ebola Virus Isolation Using Huh-7 Cells has Methodological Advantages and Similar Sensitivity to Isolation Using
Other Cell Types and Suckling BALB/c Laboratory Mice: J. Logue, W. Vargas Licona, T. K. Cooper, B. Reeder,
R. Byrum, J. Qin, N. Deiuliis Murphy, Y. Cong, A. Bonilla, J. Sword, W. Weaver, G. Kocher, G. G. Olinger, P. B. Jahrling,
L. E. Hens-ley and R. S. Bennett, Viruses 2019, PubMed ID: 30781518 - doi: 10.3390/v11020161

36.

Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy: C. Li, L. Huang, W. Sun, Y. Chen, 		
M. L. He, J. Yue and H. Ballard, Signal Transduction and Targeted Therapy 2019,
PubMed ID: - doi: 10.1038/s41392-019-0037-x

37.

MHC class II proteins mediate cross-species entry of bat influenza viruses: U. Karakus, T. Thamamongood,
K. Cimin-ski, W. Ran, S. C. Günther, M. O. Pohl, D. Eletto, C. Jeney, D. Hoffmann, S. Reiche, J. Schinköthe, R. Ulrich,
J. Wiener, M. G. B. Hayes, M. W. Chang, A. Hunziker, E. Yángüez, T. Aydillo, F. Krammer, J. Oderbolz, M. Meier,A. Oxenius, A. Halenius, G. Zimmer, C. Benner, B. G. Hale, A. García-Sastre, M. Beer, M. Schwemmle and S. Stertz, 		Nature 2019, PubMed ID: 30787439 - doi: 10.1038/s41586-019-0955-3

38.

Detection and quantification of Parascaris P-glycoprotein drug transporter expression with a novel mRNA
hybridization technique: J. J. Chelladurai and M. T. Brewer, Veterinary Parasitology 2019,
PubMed ID: - doi: 10.1016/j.vetpar.2019.02.002

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CONTINUED

Other Viruses (continued)
39.

White spot syndrome virus and the caribbean spiny lobster, panulirus argus: susceptibility and behavioral 		
immunity: E. P. Ross, D. C. Behringer and J. Bojko, J Invertebr Pathol 2019,
PubMed ID: 30731071 - doi: 10.1016/j.jip.2019.02.001

40.

Rift Valley Fever Viral RNA Detection by In Situ Hybridization in Formalin-Fixed, Paraffin-Embedded Tissues:
I. K. Ragan, K. N. Schuck, D. Upreti, L. Odendaal, J. A. Richt, J. D. Trujillo, W. C. Chauncey and A. S. Davis,
Vector Borne Zoonotic Dis 2019, PubMed ID: 30720389 - doi: 10.1089/vbz.2018.2383

41.

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection 		and Pathogenesis in Mice: V. Salazar, B. W. Jagger, J. Mongkolsapaya, K. E. Burgomaster, W. Dejnirattisai,
E. S. Win-kler, E. Fernandez, C. A. Nelson, D. H. Fremont, T. C. Pierson, J. E. Crowe, Jr., G. R. Screaton and
M. S. Diamond, Cell Rep 2019, PubMed ID: 30726740 - doi: 10.1016/j.celrep.2019.01.052

42.

Pathogenesis of Bohle Iridovirus (Genus Ranavirus) in Experimentally Infected Juvenile Eastern Water Dragons(In-tellagama lesueurii lesueurii): A. Maclaine, M. J. Forzan, N. Mashkour, J. Scott and E. Ariel, Vet Pathol 2019, 		
PubMed ID: 30686212 - doi: 10.1177/0300985818823666

43.

Attenuated Replication of Lassa Virus Vaccine Candidate ML29 in STAT-1(-/-) Mice: D. M. Johnson, J. D. Jokinen 		and I. S. Lukashevich, Pathogens 2019, PubMed ID: 30650607 - doi: 10.3390/pathogens8010009

44.

Identification of virus-encoded circular RNA: J.-t. Huang, J.-n. Chen, L.-p. Gong, Y.-h. Bi, J. Liang, L. Zhou, D. He
and C.-k. Shao, Virology 2019, PubMed ID: 28559100 - doi: https://doi.org/10.1016/j.virol.2019.01.014

45.

Recurrent PDGFRB mutations in unicentric Castleman disease: Z. Li, X. Lan, C. Li, Y. Zhang, Y. Wang, W. Xue, L. Lu,
M. Jin, Z. Zhou, X. Wang, L. Li, L. Zhang, X. Li, X. Fu, Z. Sun, J. Wu, X. Zhang, H. Yu, F. Nan, Y. Chang, J. Yan, X. Wu,
G. Wang, D. Zhang, Y. Zhang, K. H. Young and M. Zhang, Leukemia 2019,
PubMed ID: 30607019 - doi: 10.1038/s41375-018-0323-6

46.

RVFV Infection in Goats by Different Routes of Inoculation: A. L. Kroeker, V. Smid, C. Embury-Hyatt, E. Moffat,
B. Col-lignon, O. Lung, R. Lindsay and H. Weingartl, Viruses 2018, PubMed ID: 30545088 - doi: 10.3390/v10120709

47.

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi
during progression into dormancy: N. L. Bertschi, A. Voorberg-van der Wel, A. M. Zeeman, S. Schuierer, F. Nigsch,
W. Car-bone, J. Knehr, D. K. Gupta, S. O. Hofman, N. van der Werff, I. Nieuwenhuis, E. Klooster, B. W. Faber,
E. L. Flannery, S. Mikolajczak, B. Shrestha, M. Beibel, T. Bouwmeester, N. Kangwanrangsan, J. Sattabongkot,
T. T. Diagana, C. H. M. Kocken and G. Roma, Elife 2018, PubMed ID: 30589413 - doi: 10.7554/eLife.41081

48.

In situ hybridization detection and subtyping of rotaviruses in swine samples: T. P. Resende, D. Marthaler and
F. A. Vannucci, J Vet Diagn Invest 2018, PubMed ID: 30541408 - doi: 10.1177/1040638718817502

49.

Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection
and pathogenesis: S.-J. Park, Y.-I. Kim, A. Park, H.-I. Kwon, E.-H. Kim, Y.-J. Si, M.-S. Song, C.-H. Lee, K. Jung, W.-J. Shin,
J. Zeng, Y. Choi, J. U. Jung and Y. K. Choi, Nature Microbiology 2018,
PubMed ID: 30531978 - doi: 10.1038/s41564-018-0317-1

50.

Persistence of Lassa Virus Associated With Severe Systemic Arteritis in Convalescing Guinea Pigs (Cavia porcellus):
D. X. Liu, D. L. Perry, L. Evans DeWald, Y. Cai, K. R. Hagen, T. K. Cooper, L. M. Huzella, R. Hart, A. Bonilla,
J. G. Bern-baum, K. B. Janosko, R. Adams, R. F. Johnson, J. H. Kuhn, M. J. Schnell, I. Crozier, P. B. Jahrling and
J. C. de la Torre, J Infect Dis 2018, PubMed ID: 30517671 - doi: 10.1093/infdis/jiy641

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CONTINUED

Other Viruses (continued)
51.

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive
nasopharyngeal carcinoma: W. Y. Lin, Yim Ling; Jia, Lin; Deng, Wen; Zheng, Hong; Dai, Wei;
Ko, Josephine Mun Yee; Lo, Kwok Wai; Chung, Grace Tin Yun; Yip, Kevin Y.; Lee, Sau-Dan;
Kwan, Johnny Sheung-Him; Zhang, Jun; Liu, Tengfei; Chan, Jimmy Yu-Wai; Kwong, Dora Lai-Wan;
Lee, Victor Ho-Fun; Nicholls, John Malcolm; Busson, Pierre; Liu, Xuefeng; Chiang, Alan Kwok Shing; Hui, Kwai Fung;
Kwok, Hin; Cheung, Siu Tim; Cheung, Yuk Chun; Chan, Chi Keung; Li, Bin; Cheung, Annie Lai-Man; Hau, Pok Man;
Zhou, Yuan; Tsang, Chi Man; Middeldorp, Jaap; Chen, Honglin; Lung, Maria Li; Tsao, Sai Wah,Nature Communications 2018, PubMed ID: 30405107 - doi: 10.1038/s41467-018-06889-5

52.

Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs: N. N. Shiwa, C.; 		
Kimitsuki, K.; Manalo, D. L.; Noguchi, A.; Inoue, S.; Park, C. H., J Vet Med Sci 2018,
PubMed ID: 30333382 - doi: 10.1292/jvms.18-0519

53.

First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection
in Argentina: P. E. L. Pineyro, M. I.; Alarcon, L. V.; Sanguinetti, R.; Cappuccio, J. A.; Perez, E. M.; Vannucci, F.;
Armocida, A.; Madson, D. M.; Perfumo, C. J.; Quiroga, M. A., BMC Vet Res 2018,
PubMed ID: 30249258 - doi: 10.1186/s12917-018-1615-9

54.

Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates: 		
R. B. Z. Reisler, X.; Schellhase, C. W.; Bearss, J. J.; Warren, T. K.; Trefry, J. C.; Christopher, G. W.;
Kortepeter, M. G.; Bavari, S.; Cardile, A. P., Viruses 2018, PubMed ID: 30241284 - doi: 10.3390/v10100513

55.

Distinct Biological Phenotypes of Marburg and Ravn Virus Infection in Macaques: V. V. R. Nicholas, Rebecca; 		
Feldmann, Friederike; Long, Dan; Thomas, Tina; Scott, Dana P.; Feldmann, Heinz; Marzi, Andrea,
The Journal of Infectious Diseases 2018, PubMed ID: - doi: 10.1093/infdis/jiy456

56.

Localization of cassava brown streak virus in Nicotiana rustica and cassava Manihot esculenta (Crantz) using 		
RNAscope in situ hybridization: E. M. Munganyinka, Paolo; Sheat, Samar; Ateka, Elijah M.; Tairo, Fred;
Ndunguru, Jo-seph; Winter, Stephan, Virology Journal 2018, PubMed ID: 30107851 - doi: 10.1186/s12985-018-1038-z

57.

The Epstein Barr virus circRNAome: N. C. Ungerleider, M.; Lin, Z.; Roberts, C.; Wang, X.; Cao, S.; Baddoo, M.;
Moss, W. N.; Yu, Y.; Seddon, M.; Lehman, T.; Tibbetts, S.; Renne, R.; Dong, Y.; Flemington, E. K., PLoS Pathog 2018, 		
PubMed ID: 30080890 - doi: 10.1371/journal.ppat.1007206

58.

Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus: J. W. Wang, Y.;
Zhou, R.; Zhao, J.; Zhang, Y.; Yi, D.; Li, Q.; Zhou, J.; Guo, F.; Liang, C.; Li, X.; Cen, S., Viruses 2018,
PubMed ID: 29914164 - doi: 10.3390/v10060330

59.

New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model: T. K. S. Cooper, Jennifer; 		
Johnson, Joshua C.; Bonilla, Amanda; Hart, Randy; Liu, David X.; Bernbaum, John G.; Cooper, Kurt;
Jahrling, Peter B.; Hensley, Lisa E., The Journal of Infectious Diseases 2018,
PubMed ID: - doi: doi: 10.1093/infdis/jiy367

60.

The same strain of Piscine orthoreovirus (PRV-1) is involved with the development of different, but related,diseases in Atlantic and Pacific Salmon in British Columbia: F. H. Di Cicco E, Kaukinen KH, Schulze AD, Li S,
Tabata A, Gunther OP, Mordecai G, Suttle CA, Miller KM., FACETS 2018,
PubMed ID: - doi: 10.1139/facets-2018-0008

61.

A cynomolgus macaque model for Crimean-Congo haemorrhagic fever: E. F. Haddock, F.; Hawman, D. W.;
Zivcec, M.; Hanley, P. W.; Saturday, G.; Scott, D. P.; Thomas, T.; Korva, M.; Avsic-Zupanc, T.; Safronetz, D.;
Feldmann, H., Nat Mi-crobiol 2018, PubMed ID: 29632370 - doi: 10.1038/s41564-018-0141-7

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUED

Other Viruses (continued)
62.

Simian Varicella Virus Infects Enteric Neurons and alpha4beta7 Integrin-Expressing Gut-Tropic T-Cells in
Nonhuman Primates: W. J. D. v. V. Ouwendijk, S.; Mehraban, T.; Mahalingam, R.; Verjans, Gmgm, Viruses 2018, 		
PubMed ID: 29597335 - doi: 10.3390/v10040156

63.

DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa andEbola viruses in guinea pigs: K. A. W. Cashman, E. R.; Wollen, S. E.; Shamblin, J. D.; Zelko, J. M.; Bearss, J. J.;
Zeng, X.; Broderick, K. E.; Schmaljohn, C. S., Hum Vaccin Immunother 2017,
PubMed ID: 29135337 - doi: 10.1080/21645515.2017.1382780

64.

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues inthe Ebola virus disease guinea pig model: T. K. H. Cooper, L.; Johnson, J. C.; Rojas, O.; Yellayi, S.;
Sun, M. G.; Bavari, S.; Bonilla, A.; Hart, R.; Jahrling, P. B.; Kuhn, J. H.; Zeng, X., Sci Rep 2018,
PubMed ID: 29352230 - doi: 10.1038/s41598-018-19638-x

65.

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in
Rhesus Macaques: N. A. A. Crossland, Xavier; Embers, Monica E., The American Journal of Pathology 2017, 		
PubMed ID: 29242055 - doi: 10.1016/j.ajpath.2017.11.005

66.

Measuring bovine gammadelta T cell function at the site of Mycobacterium bovis infection: R. A. P. Rusk, M. V.;
Wa-ters, W. R.; McGill, J. L., Vet Immunol Immunopathol 2017,
PubMed ID: 29129226 - doi: 10.1016/j.vetimm.2017.10.004

67.

HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice: R. D. Esser AK, Xiang J, Harding 		
JC, Kohart NA, Ross MH, Su X, Wu K, Huey D, Xu Y, Vij K, Green PL, Rosol TJ, Niewiesk S, Ratner L, Weilbaecher KN.,
Oncotarget. 2017; 8:69250-69263. 2017, PubMed ID: - doi: 10.18632/oncotarget.20565

68.

Nidovirus-Associated Proliferative Pneumonia in the Green Tree Python (Morelia viridis): E. H. Dervas, J.;
Laimbacher, A.; Romero-Palomo, F.; Jelinek, C.; Keller, S.; Smura, T.; Hepojoki, S.; Kipar, A.; Hetzel, U., J Virol 2017,
PubMed ID: 28794044 - doi: 10.1128/jvi.00718-17

69.

A Naturally Transmitted Epitheliotropic Polyomavirus Pathogenic in Immunodeficient Rats: Characterization,
Transmission, and Preliminary Epidemiologic Studies: C. P. Besch-Williford, P.; Hamilton, S.; Bauer, B.;
Kapusinszky, B.; Phan, T.; Delwart, E.; Livingston, R.; Cushing, S.; Watanabe, R.; Levin, S.; Berger, D.; Myles, M.,
Toxicol Pathol 2017, PubMed ID: 28782456 - doi: 10.1177/0192623317723541

70.

Pro-inflammatory cytokine responses in extra-respiratory tissues during severe influenza: K. R. V. Short, Rebecca; 		
Leijten, Lonneke M; van den Brand, Judith M; Jong, Victor L; Stittelaar, Koert; Osterhaus, Ab DME; Andeweg, Arno;
van Riel, Debby, The Journal of Infectious Diseases 2017, PubMed ID: - doi: 10.1093/infdis/jix281

71.

Expression of host defense peptides in the intestine of Eimeria-challenged chickens: S. D. Su, D. M.; Miska, K. B.; 		
Fetterer, R. H.; Jenkins, M. C.; Wong, E. A., Poult Sci 2017, PubMed ID: 28521031 - doi: 10.3382/ps/pew468

72.

A novel RNA-based in situ hybridization to detect Seneca Valley virus in neonatal piglets and sows affected withvesicular disease: T. P. M. Resende, D. G.; Vannucci, F. A., PLoS One 2017,
PubMed ID: 28394893 - doi: 10.1371/journal.pone.0173190

73.

A novel pulmonary polyomavirus in alpacas (Vicugna pacos): F. N. Dela Cruz, Jr.; Li, L.; Delwart, E.; Pesavento, P. A.,
Vet Microbiol 2017, PubMed ID: 28284622 - doi: 10.1016/j.vetmic.2017.01.005

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CONTINUED

Other Viruses (continued)
74.

Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration
through S1P receptor 3: H. M. L. Lee, K. W.; Wei, W.; Tsao, S. W.; Chung, G. T.; Ibrahim, M. H.; Dawson, C. W.;
Murray, P. G.; Paterson, I. C.; Yap, L. F., J Pathol 2017, PubMed ID: 28240350 - doi: 10.1002/path.4879

75.

Detection of a novel sapelovirus in central nervous tissue of pigs with polioencephalomyelitis in the USA:P. H. A. Arruda, B. L.; Schwartz, K. J.; Vannucci, F.; Resende, T.; Rovira, A.; Sundberg, P.; Nietfeld, J.; Hause, B. M., 		
Transbound Emerg Dis 2017, PubMed ID: 28160432 - doi: 10.1111/tbed.12621

76.

Norovirus Infection in Harbor Porpoises: M. B. de Graaf, R.; van Elk, C. E.; van de Bildt, M.; Getu, S.; Aron, G. I.; 		
Verjans, G. M.; Osterhaus, A. D.; van den Brand, J. M.; Kuiken, T.; Koopmans, M. P., Emerg Infect Dis 2017,
PubMed ID: 27983498 - doi: 10.3201/eid2301.161081

77.

Identifying Early Target Cells of Nipah Virus Infection in Syrian Hamsters: L. S. Baseler, D. P.; Saturday, G.; Horne, E.;
Rosenke, R.; Thomas, T.; Meade-White, K.; Haddock, E.; Feldmann, H.; de Wit, E., PLoS Negl Trop Dis 2016,
PubMed ID: 27812087 - doi: 10.1371/journal.pntd.0005120

78.

Gammadelta T cells and the immune response to respiratory syncytial virus infection: J. L. S. McGill, R. E.,
Vet Immunol Immunopathol 2016, PubMed ID: 26923879 - doi: 10.1016/j.vetimm.2016.02.012

79.

Simultaneous visualization of two Citrus tristeza virus genotypes provides new insights into the structure of 		
multi-component virus populations in a host: M. P. Bergua, D. M.; Bak, A.; Bloom, D. C.; Folimonova, S. Y.,
Virology 2016, PubMed ID: 26874013 - doi: 10.1016/j.virol.2016.01.017

80.

Characterization of the immune response in ganglia after primary simian varicella virus infection:
W. J. G. Ouwendijk, S.; Mahalingam, R.; Gilden, D.; Osterhaus, A. D.; Verjans, G. M., J Neurovirol 2016,
PubMed ID: 26676825 - doi: 10.1007/s13365-015-0408-1

81.

Immunologic Control of Mus musculus Papillomavirus Type 1: J. W. J. Wang, R.; Peng, S.; Chang, Y. N.; Hung, C. F.;
Roden, R. B., PLoS Pathog 2015, PubMed ID: 26495972 - doi: 10.1371/journal.ppat.1005243

82.

Localization of Bovine Papillomavirus Nucleic Acid in Equine Sarcoids: A. M. Z. Gaynor, K. W.; Dela Cruz, F. N., Jr.; 		
Affolter, V. K.; Pesavento, P. A., Vet Pathol 2016, PubMed ID: 26215759 - doi: 10.1177/0300985815594852

83.

Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy: S. J. A. Bissel, R. N.; Chiang, C. H.; Kofler, J.;
Murdoch, G. H.; Nix, W. A.; Painter, M.; Richer, M.; Sartelet, H.; Wang, G.; Wiley, C. A.,
J Neuropathol Exp Neurol 2015, PubMed ID: 26115191 - doi: 10.1097/nen.0000000000000215

84.

Detection of Circovirus in Foxes with Meningoencephalitis, United Kingdom, 2009-2013: S. W. Bexton, L. C.;
Getu, S.; van Run, P. R.; Verjans, G. M.; Schipper, D.; Schapendonk, C. M.; Bodewes, R.; Oldroyd, L.; Haagmans, B. L.;
Koopmans, M. M.; Smits, S. L., Emerg Infect Dis 2015, PubMed ID: 26079061 - doi: 10.3201/eid2107.150228

85.

Hamster-adapted Sin Nombre virus causes disseminated infection and efficiently replicates in pulmonary
endothelial cells without signs of disease: D. P. Safronetz, J.; Haddock, E.; Scott, D. P.; Feldmann, H.; Ebihara, H.,
J Virol 2013 PubMed ID: 23388711 - doi: 10.1128/jvi.03291-12

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CONTINUED

HPV
1.

Development of C-TILDA: a modified TILDA method for reservoir quantification in long term treated patients
infected with subtype C HIV-1: A. Bertoldi, V. D’Urbano, I. Bon, A. Verbon, C. Rokx, C. Boucher,
J. J. A. van Kampen, R. A. Gruters, G. Gallinella, L. Calza, T. Mahmoudi, E. De Crignis and M. C. Re,
Journal of Virological Methods 2019, PubMed ID: 31756409 - doi: 10.1016/j.jviromet.2019.113778

2.

Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature:
A multicenter study using FFPE samples: C. Chen, P. Lohavanichbutr, Y. Zhang, J. R. Houck, M. P. Upton,
B. Abedi-Ardekani, A. Agudo, W. Ahrens, L. Alemany, D. Anantharaman, D. I. Conway, N. D. Futran, I. Holcatova,
K. Gunther, B. T. Hansen, C. M. Healy, D. Itani, K. Kjaerheim, M. M. Monroe, P. J. Thomson, B. L. Witt, S. Nakoneshny,
L. A. Peterson, S. M. Schwartz, K. R. Zarins, M. Hashibe, P. Brennan, L. S. Rozek, G. Wolf, J. C. Dort and P. Wang,
Oral Oncol 2019, PubMed ID: 31835136 - doi: 10.1016/j.oraloncology.2019.104487

3.

Evaluation of P16 as a surrogate marker for transcriptionally active HPV status of Oropharyngeal Squamous Cell 		
Carcinoma in an eastern Chinese population: S. Xu, B. Sun, R. Zhou, C. Shi, Y. Han, J. Li, J. Sun, Z. Tian, Z. Zhang and
J. Li, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2019,
PubMed ID: - doi: https://doi.org/10.1016/j.oooo.2019.11.008

4.

Elemental Zn and its Binding Protein Zinc-α2-Glycoprotein are Elevated in HPV-Positive Oropharyngeal Squamous
Cell Carcinoma: K. Poropatich, T. Paunesku, A. Zander, B. Wray, M. Schipma, P. Dalal, M. Agulnik, S. Chen, B. Lai,
O. Antipova, E. Maxey, K. Brown, M. B. Wanzer, D. Gursel, H. Fan, A. Rademaker, G. E. Woloschak and B. B. Mittal, 		
Scientific Reports 2019, PubMed ID: 31740720 - doi: 10.1038/s41598-019-53268-1

5.

Human Papillomavirus Related Multiphenotypic Sinonasal Carcinoma: Report of a Case with Early and Progressive
Metastatic Disease: A. I. Rodarte, A. S. Parikh, S. K. Gadkaree, A. E. Lehmann, W. C. Faquin, E. H. Holbrook andD. T. Lin, J Neurol Surg Rep 2019, PubMed ID: - doi: 10.1055/s-0039-3399571

6.

Morphology, p16, HPV, and outcomes in squamous cell carcinoma of the penis: a multi-institutional study:
M. L. Eich, M. Del Carmen Rodriguez Pena, L. Schwartz, C. P. Granada, S. Rais-Bahrami, G. Giannico, B. M. Amador,
A. Matoso and J. Gordetsky, Hum Pathol 2019, PubMed ID: 31698006 - doi: 10.1016/j.humpath.2019.09.013

7.

High-risk HPV E6/E7 mRNA in situ hybridization in endocervical glandular neoplasia: performance compared with
p16INK4a and Ki67 immunochemistry: J. L. Tingting Chen, Shunni Wang, Yan Ning, Xianrong Zhou, Yiqin Wan,
Am J Transl Res 2019, PubMed ID: 31737201

8.

Immunity to commensal papillomaviruses protects against skin cancer: J. D. Strickley, J. L. Messerschmidt,
M. E. Awad, T. Li, T. Hasegawa, D. T. Ha, H. W. Nabeta, P. A. Bevins, K. H. Ngo, M. M. Asgari, R. M. Nazarian, V. A. Neel,A. B. Jenson, J. Joh and S. Demehri, Nature 2019, PubMed ID: 31666702 - doi: 10.1038/s41586-019-1719-9

9.

Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma: B. H. Chamseddin,
E. E. Lee, J. Kim, X. Zhan, R. Yang, K. M. Murphy, C. Lewis, G. A. Hosler, S. T. Hammer and R. C. Wang,
Oncotarget 2019, Pub-Med ID: 31666927 - doi: 10.18632/oncotarget.27234

10.

Conjunctival intraepithelial neoplasia and carcinoma: distinct clinical and histological features in relation to humanpapilloma virus status: I. Ramberg, P. B. Toft, J. B. Georgsen, V. D. Siersma, M. Funding, D. H. Jensen,
C. von Buchwald and S. Heegaard, Br J Ophthalmol 2019,
PubMed ID: 31649051 - doi: 10.1136/bjophthalmol-2019-315011

11.

Tissue Fixation Conditions for p16 Immunohistochemistry and Human Papillomavirus RNA In Situ Hybridizationin Oropharyngeal Squamous Cell Carcinoma: J. S. Lewis, Jr., S. B. Barnett, K. Mannion and M. Mehrad,
Head and neck pathology 2019, PubMed ID: 31628584 - doi: 10.1007/s12105-019-01090-6

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CONTINUEDHPV (continued)
12.

HPV can establish productive infection in dysplastic oral mucosa, but HPV status is poorly predicted by histologicalfeatures and p16 expression: N. Hendawi, S. Niklander, O. Allsobrook, S. A. Khurram, R. Bolt, J. Doorbar,
P. M. Speight and K. D. Hunter, Histopathology 2019, PubMed ID: 31617604 - doi: 10.1111/his.14019

13.

Human papillomavirus type 16 causes a defined subset of conjunctival in situ squamous cell carcinomas:
H. Griffin, H. Singh Mudhar, P. Rundle, A. Shiraz, R. Mahmood, N. Egawa, W. Quint, I. G. Rennie and J. Doorbar,
Mod Pathol 2019, PubMed ID: 31485010 - doi: 10.1038/s41379-019-0350-5

14.

Human Papillomavirus–Associated Oropharyngeal High-Grade Neuroendocrine Carcinoma in an Adolescent:Case Report and Review of Literature: S. Sinno, A. M. Assaad and N. Salem Shabb,
Clinical Medicine Insights: Pediatrics 2019, PubMed ID: - doi: 10.1177/1179556519870520

15.

Comparative Performance of High-Risk Human Papillomavirus RNA and DNA In Situ Hybridization on Collegeof American Pathologists Proficiency Tests: E. S. Keung, R. J. Souers, J. A. Bridge, W. C. Faquin, R. P. Graham,
M. R. Hameed, J. S. Lewis, Jr., J. D. Merker, P. Vasalos and J. T. Moncur, Arch Pathol Lab Med 2019,
PubMed ID: 31483999 - doi: 10.5858/arpa.2019-0093-CP

16.

A clinicopathological and molecular analysis of cervical carcinomas with basaloid features: H. Shi, Y. Shao, Q. Liu,
S. Wang, W. Lu and B. Lu, Histopathology 2019, PubMed ID: 31393622 - doi: 10.1111/his.13968

17.

HPV-ISH-Negative Invasive Cervical Squamous Cell Carcinoma: Histologic and Pap Test Results: C. Alexander,
M. White, Z. Maleki and E. F. Rodriguez, Acta Cytol 2019, PubMed ID: 31195388 - doi: 10.1159/000500595

18.

PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in Conjunctival
Squamous Cell Carcinoma: P. Nagarajan, C. El-Hadad, S. K. Gruschkus, J. Ning, C. W. Hudgens, O. Sagiv, N. Gross, 		
M. T. Tetzlaff and B. Esmaeli, Invest Ophthalmol Vis Sci 2019, PubMed ID: 31141610 - doi: 10.1167/iovs.19-26894

19.

Detection of HPV RNA molecules in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent
cervical intraepithelial lesion: a case report: S. Fukui, K. Nagasaka, N. Iimura, R. Kanda, T. Ichinose, T. Sugihara,
H. Hiraike, S. Nakagawa, Y. Sasajima and T. Ayabe, Virol J 2019, PubMed ID: 31159808 - doi: 10.1186/s12985-019-1180-2

20.

Immunogenic neoantigens derived from gene fusions stimulate T cell responses: W. Yang, K. W. Lee,R. M. Srivasta-va, F. Kuo, C. Krishna, D. Chowell, V. Makarov, D. Hoen, M. G. Dalin, L. Wexler, R. Ghossein, N. Katabi,
Z. Nadeem, M. A. Cohen, S. K. Tian, N. Robine, K. Arora, H. Geiger, P. Agius, N. Bouvier, K. Huberman, K. Vanness,
J. J. Havel, J. S. Sims, R. M. Samstein, R. Mandal, J. Tepe, I. Ganly, A. L. Ho, N. Riaz, R. J. Wong, N. Shukla, T. A. Chan 		and L. G. T. Morris, Nat Med 2019, PubMed ID: 31011208 - doi: 10.1038/s41591-019-0434-2

21.

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines:
a two-tier approach: S. G. Craig, L. A. Anderson, A. G. Schache, M. Moran, L. Graham, K. Currie, K. Rooney,
M. Robinson, N. S. Upile, R. Brooker, M. Mesri, V. Bingham, S. McQuaid, T. Jones, D. J. McCance, M. Salto-Tellez,
S. S. McDade and J. A. James, Br J Cancer 2019, PubMed ID: 30890775 - doi: 10.1038/s41416-019-0414-9

22.

High-risk type human papillomavirus infection and p16 expression in laryngeal cancer: A. Kiyuna, T. Ikegami,
T. Uehara, H. Hirakawa, S. Agena, J. Uezato, S. Kondo, Y. Yamashita, Z. Deng, H. Maeda, M. Suzuki and A. Ganaha, 		Infectious Agents and Cancer 2019, PubMed ID: - doi: 10.1186/s13027-019-0224-y

23.

[Clinicopathological characteristics of HPV(+) oropharyngeal squamous cell carcinoma]: Y. H. Zhao, Y. P. Bai,
M. L. Mao, H. Zhang, X. L. Zhao, D. M. Yang, H. F. Wan and H. G. Liu, Zhonghua Bing Li Xue Za Zhi 2019,
PubMed ID: 30695865 - doi: 10.3760/cma.j.issn.0529-5807.2019.02.010

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDHPV (continued)
24.

Oral Human Papillomavirus Infection and Head and Neck Squamous Cell Carcinoma in Rural Northwest
Cameroon: E. M. Rettig, Z. Gooi, R. Bardin, M. Bogale, L. Rooper, E. Acha and W. M. Koch, OTO Open 2019,
PubMed ID: - doi: 10.1177/2473974X18818415

25.

Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma:
A nationwide study in Finland: M. Ruuskanen, H. Irjala, H. Minn, T. Vahlberg, R. Randen-Brady, J. Hagstrom,
S. Syrjanen and I. Leivo, Head Neck 2018, PubMed ID: 30549170 - doi: 10.1002/hed.25450

26.

The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of theuterine cervix: A. F. Nicol, C. V. de Andrade, S. C. Gomes, M. G. Brusadelli, H. M. Lodin, S. I. Wells and G. J. Nuovo, 		Annals of Diagnostic Pathology 2018, PubMed ID: - doi: 10.1016/j.anndiagpath.2018.12.001

27.

Human papillomavirus infection and its biomarkers’ expressions in laryngeal basaloid squamous cell carcinoma:
L. Cui, C. Qu and H. Liu, J Int J Clin Exp Pathol 2018, PubMed ID: 31949619

28.

SOX10 Immunoexpression in Basaloid Squamous Cell Carcinomas: A Diagnostic Pitfall for Ruling out Salivary 		
Differentiation: L. M. Rooper, A. M. McCuiston, W. H. Westra and J. A. Bishop, Head Neck Pathol 2018,
PubMed ID: 30498968 - doi: 10.1007/s12105-018-0990-7

29.

HPV-associated neuroendocrine carcinomas of the head and neck in FNA biopsies: Clinicopathologic featuresof a rare entity: V. Y. Jo, J. F. Krane, L. Pantanowitz and S. E. Monaco, Cancer Cytopathol 2018,
PubMed ID: 30475447 - doi: 10.1002/cncy.22075

30.

Cytopathologic characteristics of HPV-related small cell carcinoma of the oropharynx: D. B. Allison,
L. M. Rooper, S. Mustafa, Z. Maleki, P. E. Wakely, Jr. and S. Z. Ali, Cancer Cytopathol 2018,
PubMed ID: 30468701 - doi: 10.1002/cncy.22078

31.

HPV RNA in situ hybridization can inform cervical cytology-histology correlation: J. D. W. Coppock, B. C.; 		
Stoler, M. H.; Mills, A. M., Cancer Cytopathol 2018, PubMed ID: 29975461 - doi: 10.1002/cncy.22027

32.

Distinct biological types of ocular adnexal sebaceous carcinoma: HPV-driven and virus-negative tumors arise
through non-overlapping molecular-genetic alterations: M. T. C. Tetzlaff, J. L.; Ning, J.; Sagiv, O.; Kandl, T.; Peng, B.;
Bell, D.; Routbort, M. J.; Hudgens, C. W.; Ivan, D.; Kim, T.; Chen, K.; Eterovic, A. K.; Shaw, K. R. M.; Prieto, V. G.;
Yemel-yanova, A.; Esmaeli, B., Clin Cancer Res 2018, PubMed ID: 30420449 - doi: 10.1158/1078-0432.Ccr-18-1688

33.

Cervical adenosquamous carcinoma: detailed analysis of morphology, immunohistochemical profile, and clinicaloutcomes in 59 cases: S. H. Stolnicu, L.; Hanko-Bauer, O.; Barsan, I.; Terinte, C.; Pesci, A.; Aviel-Ronen, S.;
Kiyokawa, T.; Alvarado-Cabrero, I.; Oliva, E.; Park, K. J.; Soslow, R. A., Mod Pathol 2018,
PubMed ID: 30258209 - doi: 10.1038/s41379-018-0123-6

34.

FOLFCIS Treatment and Genomic Correlates of Response in Advanced Anal Squamous Cell Cancer:
S. C. Mondaca, Walid K.; Bates, David; Hechtman, Jaclyn F.; Cercek, Andrea; Segal, Neil H.; Stadler, Zsofia K.;
Varghese, Anna M.; Kundra, Ritika; Capanu, Marinela; Shia, Jinru; Schultz, Nikolaus; Saltz, Leonard; Yaeger, Rona, 		Clinical Colorectal Cancer 2018, PubMed ID: - doi: https://doi.org/10.1016/j.clcc.2018.09.005

35.

Immunotherapy targeting HPV 16/18 generates potent immune responses in HPV-Associated Head andNeck Cancer: C. C. Aggarwal, Roger B.; Morrow, Matthew P; Kraynak, Kimberly A.; Sylvester, Albert J.;
Knoblock, Dawson M.; Bauml, Joshua; Weinstein, Gregory S.; Lin, Alexander; Boyer, Jean; Sakata, Lindsay;
Tan, Sophie; Anton, Aubrey; Dick-erson, Kelsie; Mangrolia, Drishty; Vang, Russell; Dallas, Michael; Oyola, Sandra; 		
Duff, Susan; Esser, Mark T; Kumar, Rakesh; Weiner, David B; Csiki, Ildiko; Bagarazzi, Mark,Clinical Cancer Research 2018, PubMed ID: - doi: 10.1158/1078-0432.Ccr-18-1763

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDHPV (continued)
36.

Potential clinical implications of HPV status and expressions of p53 and cyclin D1 among oropharyngeal
cancer patients: X. J. L. David Lu, K. Y. P.; Soares, R. C.; Thomson, T.; Prisman, E.; Wu, J.; Poh, C. F.,
J Oral Pathol Med 2018, PubMed ID: 30191616 - doi: 10.1111/jop.12779

37.

Immunohistochemical detection of E7 human papillomavirus protein in premalignant and malignant lesionsof the uterine cervix: L. H. Shi, F.; Shi, C.; Huang, Y.; Liu, Y.; Chang, X., Mol Med Rep 2018,
PubMed ID: 30132548 - doi: 10.3892/mmr.2018.9416

38.

Survival rates for patients with barrett high-grade dysplasia and esophageal adenocarcinoma with or without
human papillomavirus infection: S. X. Rajendra, W.; Merrett, N.; et al.,, JAMA Network Open 2018,
PubMed ID: - doi: 10.1001/jamanetworkopen.2018.1054

39.

Human papillomavirus exposure and sexual behavior are significant risk factors for Barrett’s
dysplasia/esophageal adenocarcinoma: M. Y. W. W. Wong, B.; Yang, A.; Khor, A.; Xuan, W.; Rajendra, S.,
Dis Esophagus 2018, PubMed ID: 29931323 - doi: 10.1093/dote/doy051

40.

HPV RNA CISH score identifies two prognostic groups in a p16 positive oropharyngeal squamous cell carcinoma
population: J. M. Augustin, M.; Outh-Gauer, S.; Grard, O.; Gasne, C.; Lepine, C.; Mirghani, H.; Hans, S.;
Bonfils, P.; Denize, T.; Bruneval, P.; Bishop, J. A.; Fontugne, J.; Pere, H.; Tartour, E.; Badoual, C., Mod Pathol 2018, 		
PubMed ID: 29925856 - doi: 10.1038/s41379-018-0090-y

41.

Stromal invasion pattern identifies patients at lowest risk of lymph node metastasis in HPV-associatedendocervical adenocarcinomas, but is irrelevant in adenocarcinomas unassociated with HPV: S. B. Stolnicu, I.;
Hoang, L.; Patel, P.; Terinte, C.; Pesci, A.; Aviel-Ronen, S.; Kiyokawa, T.; Alvarado-Cabrero, I.; Oliva, E.;
Park, K. J.; Abu-Rustum, N. R.; Pike, M. C.; Soslow, R. A., Gynecol Oncol 2018,
PubMed ID: 29859673 - doi: 10.1016/j.ygyno.2018.04.570

42.

Increasing prevalence of human papillomavirus-positive oropharyngeal cancers among older adults:
M. J. D. S. Windon, G.; Rettig, E. M.; Westra, W. H.; van Zante, A.; Wang, S. J.; Ryan, W. R.; Mydlarz, W. K.; Ha, P. K.;
Miles, B. A.; Koch, W.; Gourin, C.; Eisele, D. W.; Fakhry, C., Cancer 2018, PubMed ID: 29710393 - doi: 10.1002/cncr.31385

43.

HPV Virus Transcriptional Status Assessment in a Case of Sinonasal Carcinoma: G. R. Ilardi, D.; Varricchio, S.;
Salzano, G.; Dell’Aversana Orabona, G.; Napolitano, V.; Di Crescenzo, R. M.; Borzillo, A.; Martino, F.; Merolla, F.;
Mascolo, M.; Staibano, S., Int J Mol Sci 2018, PubMed ID: 29547549 - doi: 10.3390/ijms19030883

44.

Prognostic factors for human papillomavirus-positive and negative oropharyngeal carcinomas: L. X. D. S. Yin, G.; 		
Westra, W. H.; Wang, S. J.; van Zante, A.; Zhang, Y.; Rettig, E. M.; Ryan, W. R.; Ha, P. K.; Wentz, A.; Koch, W.;
Eisele, D. W.; Fakhry, C., Laryngoscope 2018, PubMed ID: 29536542 - doi: 10.1002/lary.27130

45.

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report Documenting the Potential
for Very Late Tumor Recurrence: A. A. L. Shah, E. D.; Bishop, J. A., Head Neck Pathol 2018,
PubMed ID: 29445997 - doi: 10.1007/s12105-018-0895-5

46.

Comparison of clinical, radiological and morphological features including the distribution of HPV E6/E7
oncogenes in resection specimens of oropharyngeal squamous cell carcinoma: H. I. K. Channir, K.; Rubek, N.; 		
Andersen, J.; Georgsen, J. B.; Rathje, G. S.; Charabi, B. W.; von Buchwald, C.; Lajer, C. B., Oral Oncol 2018,
PubMed ID: 29496046 - doi: 10.1016/j.oraloncology.2018.01.029

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDHPV (continued)
47.

Nonuniform Distribution of High-risk Human Papillomavirus in Squamous Cell Carcinomas of the Oropharynx:
Rethinking the Anatomic Boundaries of Oral and Oropharyngeal Carcinoma From an Oncologic HPV Perspective:
E. M. Gelwan, I. J.; Khararjian, A.; Fakhry, C.; Bishop, J. A.; Westra, W. H., Am J Surg Pathol 2017,
PubMed ID: 28877058 - doi: 10.1097/pas.0000000000000929

48.

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification
for Invasive Adenocarcinomas of the Endocervix: S. B. Stolnicu, I.; Hoang, L.; Patel, P.; Terinte, C.; Pesci, A.;
Aviel-Ronen, S.; Kiyokawa, T.; Alvarado-Cabrero, I.; Pike, M. C.; Oliva, E.; Park, K. J.; Soslow, R. A.,
Am J Surg Pathol 2018, PubMed ID: 29135516 - doi: 10.1097/pas.0000000000000986

49.

MAML2 Rearrangements in Variant Forms of Mucoepidermoid Carcinoma: Ancillary Diagnostic Testing for the 		
Ciliated and Warthin-like Variants: J. A. C. Bishop, M. L.; Shum, C. H.; Westra, W. H., Am J Surg Pathol 2018,
PubMed ID: 28877061 - doi: 10.1097/pas.0000000000000932

50.

Expression and Significance of Cytokeratin 7, a Squamocolumnar Junction Marker, in Head and Neck Squamous
Cell Carcinoma: M. D. Mehrad, W. D.; Plummer, W. D., Jr.; Lewis, J. S., Jr., Head Neck Pathol 2017,
PubMed ID: 29235037 - doi: 10.1007/s12105-017-0874-2

51.

p16 Immunohistochemistry in Oropharyngeal Squamous Cell Carcinoma Using the E6H4 Antibody Clone:
A Technical Method Study for Optimal Dilution: J. S. Lewis, Jr.; Shelton, J.; Kuhs, K. L.; K. Smith D,
Head Neck Pathol 2017, PubMed ID: 29190003 - doi: 10.1007/s12105-017-0871-5

52.

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer:
S. V. T. Puram, Itay; Parikh, Anuraag S.; Patel, Anoop P.; Yizhak, Keren; Gillespie, Shawn; Rodman, Christopher;
Luo, Christina L.; Mroz, Edmund A.; Emerick, Kevin S.; Deschler, Daniel G.; Varvares, Mark A.; Mylvaganam, Ravi; 		
Rozenblatt-Rosen, Orit; Rocco, James W.; Faquin, William C.; Lin, Derrick T.; Regev, Aviv; Bernstein, Bradley E.,
Cell 2017, PubMed ID: 29198524 - doi: 10.1016/j.cell.2017.10.044

53.

HPV E6/E7 mRNA In Situ Hybridization in the Diagnosis of Cervical Low-grade Squamous Intraepithelial
Lesions (LSIL): A. M. C. Mills, J. D.; Willis, B. C.; Stoler, M. H., Am J Surg Pathol 2017,
PubMed ID: 29112014 - doi: 10.1097/pas.0000000000000974

54.

Correlation of Circulating CD64+/CD163+ Monocyte Ratio and stroma/peri-tumoral CD163+ Monocyte Densitywith Human Papillomavirus Infected Cervical Lesion Severity: P. P. Swangphon, C.; Sunthamala, N.;
Bumrungthai, S.; Azuma, M.; Kleebkaow, P.; Tangsiriwatthana, T.; Sangkomkamhang, U.; Kongyingyoes, B.;
Ekalaksananan, T., Cancer Microenviron 2017, PubMed ID: 29064053 - doi: 10.1007/s12307-017-0200-2

55.

The role of human papillomavirus in p16 positive oral cancers: S. C. Belobrov, A. M.; Young, R. J.; Koo, K.;Angel, C.; Wiesenfeld, D.; Rischin, D.; Garland, S. M.; McCullough, M., J Oral Pathol Med 2017,
PubMed ID: 29024035 - doi: 10.1111/jop.12649

56.

In situ hybridization detection methods for HPV16 E6/E7 mRNA in identifying transcriptionally active HPV infectionof oropharyngeal carcinoma: an updating: C. C. C. Volpi, Chiara M.; Gualeni, Ambra V.; Plebani, Maddalena;
Alfieri, Salvatore; Verderio, Paolo; Locati, Laura; Perrone, Federica; Quattrone, Pasquale; Carbone, Antonino;
Pilotti, Silvana; Gloghini, Annunziata, Human Pathology 2017,
PubMed ID: - doi: https://doi.org/10.1016/j.humpath.2017.09.011

57.

Carcinoma of the Urethra: M. A. Zhang, A. J.; Vikram, R.; Tamboli, P.; Pettaway, C.; Bondaruk, J.; Liu, J.; Baggerly, K.;
Czerniak, B., Hum Pathol 2017, PubMed ID: 28827100 - doi: 10.1016/j.humpath.2017.08.006

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDHPV (continued)
58.

Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of
HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options: R. E. N. Brown, S.;
McGuire, M. F.; Buryanek, J.; Karni, R. J., J Otolaryngol Head Neck Surg 2017,
PubMed ID: 28818106 - doi: 10.1186/s40463-017-0230-2

59.

Automated RNA In Situ Hybridization for 18 High Risk Human Papilloma Viruses in Squamous Cell Carcinoma of 		the Head and Neck: Comparison With p16 Immunohistochemistry: B. C. Drumheller, C.; Lawson, D.; Siddiqui, M. T.,
Appl Immunohistochem Mol Morphol 2017, PubMed ID: 28777152 - doi: 10.1097/pai.0000000000000550

60.

Amplification of EGFR and cyclin D1 genes associated with human papillomavirus infection in oral squamous cell
carcinoma: J. P. Chuerduangphui, C.; Patarapadungkit, N.; Chotiyano, A.; Vatanasapt, P.; Kongyingyoes, B.;
Promthet, S.; Swangphon, P.; Bumrungthai, S.; Pimson, C.; Ekalaksananan, T., Med Oncol 2017,
PubMed ID: 28741068 - doi: 10.1007/s12032-017-1010-6

61.

Active human papillomavirus involvement in Barrett’s dysplasia and oesophageal adenocarcinoma ischaracterized by wild-type p53 and aberrations of the retinoblastoma protein pathway: S. Y. Rajendra, T.; Xuan, W.;
Sharma, P.; Pavey, D.; Soon Lee, C.; Le, S.; Collins, J.; Wang, B., Int J Cancer 2017,
PubMed ID: 28722212 - doi: 10.1002/ijc.30896

62.

p16 immunohistochemistry in oropharyngeal squamous cell carcinoma: a comparison of antibody clones using
patient outcomes and high-risk human papillomavirus RNA status: J. P. Shelton, B. M.; Cipriani, N. A.; Dupont, W. D.;
Plummer, D.; Lewis, J. S., Jr., Mod Pathol 2017, PubMed ID: 28621317 - doi: 10.1038/modpathol.2017.31

63.

Squamous and Neuroendocrine Specific Immunohistochemical Markers in Head and Neck Squamous Cell
Carcinoma: A Tissue Microarray Study: J. S. Lewis, Jr.; Chernock, R. D.; Bishop, J. A., Head Neck Pathol 2017, 		
PubMed ID: 28528398 - doi: 10.1007/s12105-017-0825-y

64.

Spontaneous and vaccine-induced clearance of Mus musculus Papillomavirus type 1 (MmuPV1/MusPV1) infection:
R. T. W. Jiang, J. W.; Peng, S.; Huang, T. C.; Wang, C.; Cannella, F.; Chang, Y. N.; Viscidi, R. P.; Best, S. R. A.;
Hung, C. F.; Roden, R. B. S., J Virol 2017, PubMed ID: 28515303 - doi: 10.1128/jvi.00699-17

65.

SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic andClinicopathologic Spectrum of a Recently Described Entity: A. H. Agaimy, A.; Antonescu, C. R.; Chiosea, S. I.;
El-Mofty, S. K.; Geddert, H.; Iro, H.; Lewis, J. S., Jr.; Markl, B.; Mills, S. E.; Riener, M. O.; Robertson, T.; Sandison, A.;
Semrau, S.; Simpson, R. H.; Stelow, E.; Westra, W. H.; Bishop, J. A., Am J Surg Pathol 2017,
PubMed ID: 28291122 - doi: 10.1097/pas.0000000000000797

66.

RNA Chromogenic in situ Hybridization Assay with Clinical Automated Platform is a Sensitive Method in Detecting
High-risk Human Papillomavirus in Squamous Cell Carcinoma: J. E. S. Mendez-Pena, Peter M.; Nose, Vania;
Hoang, Mai P., Human Pathology 2017, PubMed ID: 28302536 - doi: http://dx.doi.org/10.1016/j.humpath.2017.02.021

67.

The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head andneck squamous cell cancer: C. W. Fakhry, W. H.; Wang, S. J.; van Zante, A.; Zhang, Y.; Rettig, E.; Yin, L. X.;
Ryan, W. R.; Ha, P. K.; Wentz, A.; Koch, W.; Richmon, J. D.; Eisele, D. W.; D’Souza, G., Cancer 2017,
PubMed ID: 28241096 - doi: 10.1002/cncr.30353

68.

Transcriptionally Active High-Risk Human Papillomavirus is Not a Common Etiologic Agent in the Malignant
Transformation of Inverted Schneiderian Papillomas: L. M. B. Rooper, J. A.; Westra, W. H., Head Neck Pathol 2017, 		
Pub-Med ID: 28181187 - doi: 10.1007/s12105-017-0779-0

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDHPV (continued)
69.

Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features of the Sinonasal Tract: Clinical and 		Morphological Characterization of 6 New Cases: S. B. Andreasen, J.; Hansen, T. V.; Westra, W. H.; Bilde, A.;von Buchwald, C.; Kiss, K., Histopathology 2016, PubMed ID: 28035703 - doi: 10.1111/his.13162

70.

Anal verrucous carcinoma is not related to infection with human papillomaviruses and should be distinguishedfrom giant condyloma (Buschke-Lowenstein tumor): N. L. Zidar, C.; Odar, K.; Hosnjak, L.; Kamaradova, K.; Daum, O.;
Pollheimer, M. J.; Kosorok, P.; Poljak, M., Histopathology 2016, PubMed ID: 28012208 - doi: 10.1111/his.13158

71.

Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, 		
Race, Anatomic Tumor Site, and HPV Detection Method: G. W. D’Souza, W. H.; Wang, S. J.; van Zante, A.; Wentz, A.;
Kluz, N.; Rettig, E.; Ryan, W. R.; Ha, P. K.; Kang, H.; Bishop, J.; Quon, H.; Kiess, A. P.; Richmon, J. D.; Eisele, D. W.; 		
Fakhry, C., JAMA Oncol 2016, PubMed ID: 27930766 - doi: 10.1001/jamaoncol.2016.3067

72.

Human papillomavirus (HPV) infection in a case-control study of oral squamous cell carcinoma and its increasing
trend in northeastern Thailand: P. E. Phusingha, T.; Vatanasapt, P.; Loyha, K.; Promthet, S.; Kongyingyoes, B.;
Pata-rapadungkit, N.; Chuerduangphui, J.; Pientong, C., J Med Virol 2016,
PubMed ID: 27935063 - doi: 10.1002/jmv.24744

73.

Human papillomavirus-related mixed non-keratinizing squamous cell carcinoma of the palatine tonsil with small
cell neuroendocrine carcinoma: Report of a case: Y. P. Ma, Ninad; Gagner, Jean-Pierre; Miles, Brett A.,
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2017,
PubMed ID: - doi: http://doi.org/10.1016/j.ajoms.2016.09.010

74.

Diagnosis of HPV driven oropharyngeal cancers: Comparing p16 based algorithms with the RNAscope HPV-test:
H. C. Mirghani, O.; Guerlain, J.; Amen, F.; He, M. X.; Ma, X. J.; Luo, Y.; Mourareau, C.; Drusch, F.; Lakdhar, A. B.;
Melkane, A.; St Guily, L.; Badoual, C.; Scoazec, J. Y.; Borget, I.; Auperin, A.; Dalstein, V.; Vielh, P., Oral Oncol 2016, 		
PubMed ID: 27865361 - doi: 10.1016/j.oraloncology.2016.10.009

75.

Two Distinct Isoforms of Matrix Metalloproteinase-2 Are Associated with Human Delayed Kidney Graft Function:
S. C. Wanga, C. S.; Delgado, C.; Joshi, S. K.; Spaulding, K.; Walker, J. P.; Song, S.; Olson, J. L.; Lovett, D. H.,
PLoS One 2015, PubMed ID: 26379248 - doi: 10.1371/journal.pone.0136276

76.

Presence of high risk HPV DNA but indolent transcription of E6/E7 oncogenes in invasive ductal carcinomaof breast: D. F. Wang, L.; Shah, W.; Zhang, J.; Yan, Y.; Ge, X.; He, J.; Wang, Y.; Li, X., Pathol Res Pract 2016,
PubMed ID: 27688086 - doi: 10.1016/j.prp.2016.09.009

77.

[Clinicopathologic features of non-keratinizing carcinoma of nasal cavity and paranasal sinus]: Y. H. L. Zhao, H. G.,
Zhonghua Bing Li Xue Za Zhi 2016, PubMed ID: 27646894 - doi: 10.3760/cma.j.issn.0529-5807.2016.09.010

78.

Effect of human papillomavirus 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma:
J. P. Chuerduangphui, C.; Chaiyarit, P.; Patarapadungkit, N.; Chotiyano, A.; Kongyingyoes, B.; Promthet, S.;
Swangphon, P.; Wongjampa, W.; Ekalaksananan, T., Med Oncol 2016,
PubMed ID: 27349249 - doi: 10.1007/s12032-016-0800-679.

Prognostic significance of human papillomavirus viral load in correlation with different therapeutic modalities incervical cancer patients: M. S. Cao, W.; Qi, J.; Zhou, Y.; Wang, Y.; Chen, H., Pathol Res Pract 2016,
PubMed ID: 27461827 - doi: 10.1016/j.prp.2016.06.011

80.

Linear viral load increase of a single HPV-type in women with multiple HPV infections predicts progression tocervical cancer: C. E. T. Depuydt, S.; Beert, J.; Jonckheere, J.; Salembier, G.; Bogers, J. J., Int J Cancer 2016, 		
PubMed ID: 27339821 - doi: 10.1002/ijc.30238

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDHPV (continued)
81.

Concurrent Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx in a Married Couple:
T. D. G. Brobst, J. J.; Price, K. A.; Gao, G.; Smith, D. I.; Price, D. L., Case Rep Otolaryngol 2016,
PubMed ID: 27418994 - doi: 10.1155/2016/8481235

82.

p16-positive lymph node metastases from cutaneous head and neck squamous cell carcinoma: No association 		with high-risk human papillomavirus or prognosis and implications for the workup of the unknown primary:
L. J. Y. McDowell, R. J.; Johnston, M. L.; Tan, T. J.; Kleid, S.; Liu, C. S.; Bressel, M.; Estall, V.; Rischin, D.; Solomon, B.; 		
Corry, J., Cancer 2016, PubMed ID: 26881928 - doi: 10.1002/cncr.29901

83.

Application of p16 Immunohistochemistry and RNA In Situ Hybridization in the Classification of Adenoid Basal 		Tumors of the Cervix: A. W. Goyal, Z.; Przybycin, C. G.; Yang, B., Int J Gynecol Pathol 2016,
PubMed ID: 26352551 - doi: 10.1097/pgp.0000000000000221

84.

Co-existing of adenoid cystic carcinoma and invasive squamous cell carcinoma of the uterine cervix: a report of3 cases with immunohistochemical study and evaluation of human papillomavirus status: X. W. Shi, S.; Huo, Z.; 		
Ling, Q.; Luo, Y.; Liang, Z., Diagn Pathol 2015, PubMed ID: 26285694 - doi: 10.1186/s13000-015-0376-z

85.

Ciliated HPV-related Carcinoma: A Well-differentiated Form of Head and Neck Carcinoma That Can Be
Mistaken for a Benign Cyst: J. A. W. Bishop, W. H., Am J Surg Pathol 2015,
PubMed ID: 26457358 - doi: 10.1097/pas.0000000000000521

86.

Correlation of p16 immunohistochemistry in FNA biopsies with corresponding tissue specimens in HPV-related
squamous cell carcinomas of the oropharynx: J. B. L. Jalaly, J. S., Jr.; Collins, B. T.; Wu, X.; Ma, X. J.; Luo, Y.;
Bernadt, C. T., Cancer Cytopathol 2015, PubMed ID: 26242494 - doi: 10.1002/cncy.21600

87.

Detection of human papillomavirus in non-small cell carcinoma of the lung: S. Y. K. Chang, M.; Law, M.;
Donovan, J.; Aubry, M. C.; Garcia, J., Hum Pathol 2015, PubMed ID: 26342243 - doi: 10.1016/j.humpath.2015.07.012

88.

Combined squamous cell carcinoma and Merkel cell carcinoma of the vulva: Role of human papillomavirus and 		
Merkel cell polyomavirus: C. H. W. Chen, Y. Y.; Kuo, K. T.; Liau, J. Y.; Liang, C. W., JAAD Case Rep 2015,
PubMed ID: 27051728 - doi: 10.1016/j.jdcr.2015.04.005

89.

Prevalence of HPV infection in head and neck carcinomas shows geographical variability: a comparative study
from Brazil and Germany: F. O.-S. Hauck, M.; Dreyer, J. H.; Perrusi, V. J.; Arcuri, R. A.; Hassan, R.; Bonvicino, C. R.; 		
Barros, M. H.; Niedobitek, G., Virchows Arch 2015, PubMed ID: 25820374 - doi: 10.1007/s00428-015-1761-4

90.

Persistence of Human Papillomavirus, Overexpression of p53, and Outcomes of Patients After Endoscopic Ablationof Barrett’s Esophagus: S. W. Rajendra, B.; Pavey, D.; Sharma, P.; Yang, T.; Lee, C. S.; Gupta, N.; Ball, M. J.; Gill, R. S.;
Wu, X., Clin Gastroenterol Hepatol 2015, PubMed ID: 25460562 - doi: 10.1016/j.cgh.2014.11.017

91.

Transcriptional activity of HPV in inverted papilloma demonstrated by in situ hybridization for E6/E7 mRNA:
D. G. Stoddard, Jr.; Keeney, M. G.; Gao, G.; Smith, D. I.; Garcia, J. J.; O’Brien, E. K.,
Otolaryngol Head Neck Surg 2015, Pub-Med ID: 25724573 - doi: 10.1177/0194599815571285

92.

Human papillomavirus-related head and neck squamous cell carcinoma variants: S. K. El-Mofty,
Semin Diagn Pathol 2015, PubMed ID: 25804342 - doi: 10.1053/j.semdp.2015.02.022

93.

Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally active humanpapillomavirus infection in laryngeal squamous cell carcinoma: R. J. U. Young, D.; Angel, C.; Corry, J.; Lyons, B.; 		
Vallance, N.; Kleid, S.; Iseli, T. A.; Solomon, B.; Rischin, D., Br J Cancer 2015,
PubMed ID: 25688737 - doi: 10.1038/bjc.2015.59

Discover how the RNAscope technology can advance your research at www.acdbio.com
CONTINUEDHPV (continued)
94.

Identification of transcriptionally active HPV infection in formalin-fixed, paraffin-embedded biopsies oforopharyngeal carcinoma: P. A. Morbini, P.; Tinelli, C.; Paglino, C.; Bertino, G.; Comoli, P.; Pedrazzoli, P.; Benazzo, M.,
Hum Pathol 2015, PubMed ID: 25708613 - doi: 10.1016/j.humpath.2014.12.014

95.

Identification of a human papillomavirus-associated oncogenic miRNA panel in human oropharyngeal
squamous cell carcinoma validated by bioinformatics analysis of the Cancer Genome Atlas: D. L. D. Miller, J. W.; 		
Taylor, K. H.; Johnson, J.; Shi, Z.; Williams, R.; Atasoy, U.; Lewis, J. S., Jr.; Stack, M. S., Am J Pathol 2015,
PubMed ID: 25572154 - doi: 10.1016/j.ajpath.2014.11.018

96.

Incidence trends in head and neck squamous cell carcinoma in Slovenia, 1983-2009: role of human papillomavirus
infection: P. Z. Strojan, V.; Sifrer, R.; Lanisnik, B.; Didanovic, V.; Jereb, S.; Poljak, M.; Kocjan, B. J.; Gale, N.,
Eur Arch Otorhinolaryngol 2015, PubMed ID: 25542247 - doi: 10.1007/s00405-014-3459-7

97.

Do high-risk human papillomaviruses cause oral cavity squamous cell carcinoma?: H. A. Mirghani, F.; Moreau, F.; 		
La-cau St Guily, J., Oral Oncol 2015, PubMed ID: 25488179 - doi: 10.1016/j.oraloncology.2014.11.011

98.

Characterization of inflammatory (lymphoepithelioma-like) hepatocellular carcinoma: a study of 8 cases:
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Detection of human papillomavirus (HPV) in clinical samples: evolving methods and strategies for the accurate 		determination of HPV status of head and neck carcinomas: W. H. Westra, Oral Oncol 2014,
PubMed ID: 24932529 - doi: 10.1016/j.oraloncology.2014.05.004

100. HER2 status in colorectal cancer: its clinical significance and the relationship between HER2 gene amplification 		and expression: A. N. K. Seo, Y.; Kim, D. W.; Kang, S. B.; Choe, G.; Kim, W. H.; Lee, H. S., PLoS One 2014,
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101. HPV E6/E7 RNA in situ hybridization signal patterns as biomarkers of three-tier cervical intraepithelial neoplasia
grade: M. F. P. Evans, Z.; Clark, K. M.; Adamson, C. S.; Ma, X. J.; Wu, X.; Wang, H.; Luo, Y.; Cooper, K.,
PLoS One 2014, PubMed ID: 24625757 - doi: 10.1371/journal.pone.0091142
102. Human papilloma virus testing in oropharyngeal squamous cell carcinoma: what the clinician should know:
H. A. Mirghani, F.; Moreau, F.; Guigay, J.; Ferchiou, M.; Melkane, A. E.; Hartl, D. M.; Lacau St Guily, J.,
Oral Oncol 2014, PubMed ID: 24169585 - doi: 10.1016/j.oraloncology.2013.10.008
103. Human papillomavirus (HPV) status of non-tobacco related squamous cell carcinomas of the lateral tongue:
J. S. M. Poling, X. J.; Bui, S.; Luo, Y.; Li, R.; Koch, W. M.; Westra, W. H., Oral Oncol 2014,
PubMed ID: 24485566 - doi: 10.1016/j.oraloncology.2014.01.006
104. RNAscope for in situ detection of transcriptionally active human papillomavirus in head and neck squamous cell
carcinoma: H. W. Wang, M. X.; Su, N.; Wang, L. C.; Wu, X.; Bui, S.; Nielsen, A.; Vo, H. T.; Nguyen, N.; Luo, Y.;
Ma, X. J., J Vis Exp 2014, PubMed ID: 24637627 - doi: 10.3791/51426
105. Application of circulating tumor cells scope technique on circulating tumor cell research: D. W. Yang, L.; Tian, X., 		
Mol Cell Ther 2014, PubMed ID: 26056577 - doi: 10.1186/2052-8426-2-8
106. Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamouscell carcinoma of the larynx: R. D. W. Chernock, X.; Gao, G.; Lewis, J. S., Jr.; Zhang, Q.; Thorstad, W. L.;
El-Mofty, S. K., Mod Pathol 2013, PubMed ID: 22996374 - doi: 10.1038/modpathol.2012.159

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CONTINUEDHPV (continued)
107. Detection of HPV infection in head and neck squamous cell carcinoma: a practical proposal: J. H. H. Dreyer, F.; 		
Oliveira-Silva, M.; Barros, M. H.; Niedobitek, G., Virchows Arch 2013,
PubMed ID: 23503925 - doi: 10.1007/s00428-013-1393-5
108. A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its
applica-tion in oropharyngeal cancer prognosis: G. C. Gao, R. D.; Gay, H. A.; Thorstad, W. L.; Zhang, T. R.; Wang, H.;
Ma, X. J.; Luo, Y.; Lewis, J. S., Jr.; Wang, X., Int J Cancer 2013, PubMed ID: 22821242 - doi: 10.1002/ijc.27739
109. Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special 		
reference to human papillomavirus: M. C. Mehrad, D. H.; Chernock, R. D.; Wang, H.; Ma, X. J.; Luo, Y.; Luo, J.;
Lewis, J. S., Jr.; El-Mofty, S. K., Am J Surg Pathol 2013,
PubMed ID: 23797720 - doi: 10.1097/PAS.0b013e318290427d110. Cyclin D1-a prognostic marker in oropharyngeal squamous cell carcinoma that is tightly associated with high-risk
human papillomavirus status: J. B. L. Scantlebury, J.; Thorstad, W. L.; El-Mofty, S. K.; Lewis, J. S., Jr.,
Hum Pathol 2013, PubMed ID: 23566410 - doi: 10.1016/j.humpath.2013.01.021
111. Validation of a novel diagnostic standard in HPV-positive oropharyngeal squamous cell carcinoma:
A. G. L. Schache, T.; Risk, J. M.; Jones, T. M.; Ma, X. J.; Wang, H.; Bui, S.; Luo, Y.; Sloan, P.; Shaw, R. J.; Robinson, M., 		
Br J Cancer 2013, PubMed ID: 23412100 - doi: 10.1038/bjc.2013.63
112. Spindle cell carcinomas of the head and neck rarely harbor transcriptionally-active human papillomavirus:
R. F. C. Watson, R. D.; Wang, X.; Liu, W.; Ma, X. J.; Luo, Y.; Wang, H.; El-Mofty, S. K.; Lewis, J. S., Jr.,
Head Neck Pathol 2013, PubMed ID: 23536041 - doi: 10.1007/s12105-013-0438-z
113. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as
visualized by a novel E6/E7 mRNA in situ hybridization method: J. A. M. Bishop, X. J.; Wang, H.; Luo, Y.;
Illei, P. B.; Begum, S.; Taube, J. M.; Koch, W. M.; Westra, W. H., Am J Surg Pathol 2012,
PubMed ID: 23060353 - doi: 10.1097/PAS.0b013e318265fb2b114. Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal/hypopharyngeal
squamous cell carcinomas—a tissue microarray study utilizing E6/E7 mRNA in situ hybridization:
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115. Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with humanpapillomavirus RNA status: J. S. Lewis, Jr.; Chernock, R. D.; Ma, X. J.; Flanagan, J. J.; Luo, Y.; Gao, G.; Wang, X.;
El-Mofty, S. K., Mod Pathol 2012, PubMed ID: 22596101 - doi: 10.1038/modpathol.2012.79
116. B7-H1 expression model for immune evasion in human papillomavirus-related oropharyngeal squamous cell
carcinoma: O. C. T. Ukpo, W. L.; Lewis, J. S., Jr., Head Neck Pathol 2013,
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117. RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues: F. F. Wang, J.;
Su, N.; Wang, L. C.; Bui, S.; Nielson, A.; Wu, X.; Vo, H. T.; Ma, X. J.; Luo, Y., J Mol Diagn 2012,
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118. Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of theliterature: R. P. E.-M. Masand, S. K.; Ma, X. J.; Luo, Y.; Flanagan, J. J.; Lewis, J. S., Jr., Head Neck Pathol 2011,
PubMed ID: 21305368 - doi: 10.1007/s12105-011-0245-3

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CONTINUEDHPV (continued)
119. High-risk human papillomavirus E6/E7 mRNA detection by a novel in situ hybridization assay strongly correlateswith p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma: O. C. F. Ukpo, J. J.; 		
Ma, X. J.; Luo, Y.; Thorstad, W. L.; Lewis, J. S., Jr., Am J Surg Pathol 2011,
PubMed ID: 21836494 - doi: 10.1097/PAS.0b013e318220e59d

DNA Viruses

RNA Viruses

Retro-Transcribing Viruses

ds DNAI

ss DNAII

ds RNAIII

ss RNAIV

ss RNAV

ss RNAVI

ds DNAVII

DNA (+/-)DNA (+)RNA (+/-)RNA (+)RNA (-)RNA (+)DNA (+/-)

ReverseTranscription

ReverseTranscription

DNA (+/-)DNA (+/-)RNA (-)DNA (+/-)
mRNA
Proteins

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