R002E

Gene control reagents: PIPAHiPep Laboratories focused on the research of double strand DNAs recognition in addition to proteins. Recently
industrial production of PIPA (peptides consisting of pyrrole and imidazole as building units) has been established.
By using this technology several PIPAs for research works on gene expression control are launched. Price: inquire.
Abbreviations and related information see also URL http://hipep.jp/?p=1032
P/N

Structure (C terminal amide)

Moe. weight

Target Gene
Human
TGF-β1

Ref.

HPTB01

Ac-Im-Py-Py-βAla-Im-Py-Py-γAbu-PyPy-Py-βAla-Py-Py-βAla-Dp

1787.90

HPTB02

Ac-Im-Im-βAla-Im-Py-Im-γAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp

1667.75

Human
TGF-β1

1

HPTB03

Ac-Im-Py-Im-βAla-Py-Py-Py-γAbu-Im-Py-Im-βAla-Py-Py-Py-βAla-Dp

1912.00

Human
TGF-β1

1

HPTB04

Ac-Py-Py-βAla-Py-Im-Py-γAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp

1665.78

Rat
TGF-β12HPLH05

Ac-Im-Py-Im-βAla-Py-Py-Im-γAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp

1911.01

Human
LOX-1

3

HPLR06

Ac-Py-Py-βAla-Py-Py-Im-γAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp

1667.75

Rat
LOX-1

4

HPCT07Ac-Im-Py-Py-βAla-Py-Py-Py-γAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp

1912.00

Human
CTGF

5

HPTE08

Ac-Py-Im-βAla-Im-Im-Im-γAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp

1667.75

TMPRSS2ERG

6

HPOC09Ac-Py-Py-βAla-Im-Py-Py-γAbu-Py-Im-Py-βAla-Im-Py-βAla-Dp

1666.76

Oct1

7

HPOC10Ac-Im-Py-βAla-Py-Py-Py-γAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp

1665.78Oct17HPRU11

Chlorambucil-βAla-Im-Py-Im-Im-γAbu-Py-Py-Py-Py-Dp

1523.41

RUNX

81Freeze dried, No additives, 100 µg/vial ～ 1 mg (upon requests larger scale can also be supplied)＊Labeling, Derivatizing, Design, Modifications can be performed upon requests (see also contract syntheses)

References upon request pdf can be send personally
1. Igarashi, J. et. al. Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human
TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model, PLoS One. 10, e0125295,
2015.
2. Matsuda, H. et al. Transcriptional inhibition of progressive renal disease by gene silencing pyrrole
imidazole polyamide targeting of the transforming growth factor-β1 promoter, Kidney Int. 79, 46-56,
2011.
3. Ueno, T. et al. A novel gene silencer, pyrrole–imidazole polyamide targeting human lectin-like oxidized
low-density lipoprotein receptor-1 gene improves endothelial cell function, J. Hypertens 27, 508-516,
2009.
4. Yao, E. H. et al. Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density
lipoprotein receptor-1 attenuates restenosis of the artery after injury, Hypertension, 52, 86-92, 2008.
5. Wan, J. X. et al. Development of a novel gene silencer pyrrole-imidazole polyamide targeting humanconnective tissue growth factor, Biol. Pharm. Bull. 34, 1572-1577, 2011.
6. Obinata, D. et al. Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG genefusion represses prostate tumor growth, Cancer Sci. 105, 1272-1278, 2014.
7. Obinata, D. et al. Targeting Oct1 genomic function inhibits androgen receptor signaling and castrationresistant prostate cancer growth, Oncogene, 1-6, 2016.
8. Morita, K. et al. Genetic requlation of the RUNX transcription factor family has antitumor effects, J. Clin.
Invest. 127, 2815-2828, 2017.

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TEL: 075-813-2101, FAX: 075-801-0280, E-mail: info@hipep.jp, URL: http://www.hipep.jp/