Toshio Hosaka
E-mail:toshio.hosaka@u-shizuoka-ken.ac.jp
Homepage: https://rinshoeiyo.jimdofree.com/
EDUCATION:
1994 M.D.

Yamaguchi University School ofMedicine
1999 Ph.D.

Yamaguchi University Graduate

School of Medicine
PROFESSIONAL EMPLOYMENT:
1994-1996

Resident
Third Department of Internal Medicine,
Yamaguchi University Hospital

1996-1998

Clinical Research Fellow
Third Department of Internal Medicine,
Yamaguchi University Hospital

1998-1999

Medical Staff
Division of Internal Medicine, Saiseikai Yamaguchi General Hospital

1999-2000

Senior Medical Staff
Division of Internal Medicine, Iwakuni Medical Center

2000-2002

Postdoctoral Research Fellow
Third Department of Internal Medicine,
Yamaguchi University School of Medicine

2002-2005

Research Associate
Department of Biochemistry, School of Medicine
Boston University

2005-2006

Research Associate
Division of Molecular Enzyme Genetics,
The Institute for Molecular Enzyme Research,
The University of Tokushima

2006-2007 Oct.

Associate Professor
Department of Nutrition and Metabolism Institute of Health

Biosciences University of Tokushima Graduate School
2007 Nov.-2009 Assistant Professor
Clinical Research Center for Diabetes

2009-2011

Tokushima University Medical and Dental Hospital
Assistant Professor

Department of Public Health and Applied Nutrition, Institute of Health
Biosciences University of Tokushima Graduate School
2011-2014
Associate Professor
Department of Endocrinology and Diabetes, Saitama Medical
University Hospital
2014-2018 Sep. Associate Professor,
Third Department of Internal Medicine, Division of Diabetes,
Endocrinology and Metabolism, Kyorin University School ofMedicine

2018 Oct.
-present Professor of Laboratory of Clinical Nutrition,

Department of Nutrition and Life Science,
School of Food and Nutritional Sciences,
And Professor of Graduate Program in Food and Nutritional Science,
Graduate School of Integrated Pharmaceutical and Nutritional
Science, The University of Shizuoka

PROFESSONAL SOCIETY:
Japan Diabetes Society
Japanese Society of Internal Medicine
Japanese Society for Parental and Enteral Nutrition
Japan Society of Metabolism and Clinical Nutrition
The Japan Endocrine society
Japanese Society for Treatment of Obesity
The Japan Society of Diabetic Complications
The Japanese Society of Ophthalmic Diabetology
Japan Society of Nutrition and Food Science
BOARD CERTIFICATION AND LICENSE:
Medical License : No. 361950, Japan, April 28, 1994
Coordinator of Nutrition Supports Team, Board Certified Fellow and Trainer and Councilorof Japan Society of Metabolism and Clinical Nutrition
Board Certified Fellow of Japanese Society of Internal Medicine
Board Certified Trainer and Fellow and Councilor of Japan Diabetes Society
Board Certified Trainer and Fellow of The Japan Endocrine society
Councilor of The Japan Society of Diabetic Complications
Councilor of Japan Society of Nutrition and Food Science

MAJOR RESEARCH INTERESTS

1. Molecular mechanism of glucose transport
2. Molecular mechanism of insulin resistance
3. Molecular mechanism of organic acid receptor signaling
4. Clinical aspect of diabetes nutritional therapy
REPRESENTATIVE PUBLICATIONS
1. Kawakami Y, Yasuda A, Hayashi M, Akiyama M, Asai T, hosaka T, Arai E : Acute effect ofgreen tea catechins on uric acid metabolism after alcohol ingestion in Japnanese men.
Clinical Reumatology 2021 Feb
2. Takahashi R, Yoshida T, Toku H, Otsuki N, and Hosaka T : Impact of meal timing on
postprandial interstitial fluid glucose levels in young Japanese females. J Nutr SciVitaminol. 2020 Dec 6;66: 593-596
3. Morita N, Hoaska T, Yamazaki Y , Takahashi K, Sasano H, Ishida H : Abnormal glucose
intolerance in a patient with pheochromocytoma and ACTH-independent subclinical
Cushing’s syndrome involving the same adrenal gland. J Int Med Res. 2019 Jul;47(7):33603370
4. Ishitobi M, Hosaka T, Morita N, Kondo K, Murashima T, Kitahara A, Takahashi K,Sumitani Y, Tanaka T, Yokoyama T, Kondo T, Ishida H : Serum lactate levels areassociated with serum alanine aminotransferase and total bilirubin levels in patients withtype 2 diabetes mellitus: A cross-sectional study.
Diabetes Res Clin Pract. 2019 Jan 31;149:1-8.
5. Ito S, Hosaka T, Yano W, Itou T, Yasumura M, Shimizu Y, Kobayashi H, Nakagawa T,Inoue K, Tanabe S, Kondo T, Ishida H : Metabolic Effects of Tofogliflozin are Efficiently
Enhanced with Appropriate Dietary Carbohydrate Ratio and are Distinct from Carbohydrate
Restriction. Physiological Reports 2018 Mar;6(5).
6. Morita N, Hosaka T, Kitahara A, MurashimaT, Onuma H, Sumitani Y, Takahashi K,Tanaka T, Kondo T, Ishida H : Novel mechanisms modulating palmitate-induced
inflammatory factors in hypertrophied 3T3-L1 adipocytes by AMPK. Journal of Diabetes
Research 2018 Mar 11;2018:9256482.
7. Sumitani Y, Hosaka T, Susaki Y, Fujisawa Y, Kuriyama K, Tsukada Y, Yokoyama T,Ogasawara J, Nishida S, Inukai K, Okajima Y, Ohno H, Ishida H : Clinical effect of real time
pulse rate monitoring with portable pulsimeter on physical exercise therapy for malepatients with type 2 diabetes. Diabetology International 7(3):228-234 2016
8. Iuchi T, Hosaka T, Shiroishi M, Ono H, Inukai K, Sumita T, Sakai G, Katayama S, Awata T:
Influence of treatment with extracts of Hypsyzigus marmoreus mushroom on bodycomposition during obesity development in KK-Ay mice. J Nutr Sci Vitaminol (Tokyo) 61(1)96-100, 2015.
9. Le TKC, Hosaka T, Trung NT, Kassu A, Oanh DT, Ba TH, Phuong PT, QuangBinh T :Bifidobacterium species lower serum glucose, increase insulin signaling protein
expressions and improve adipokine profile in diabetic mice.. BIOMEDICAL RESEARCH
36(1) 63-70, 2015.
10. Le TKC, Hosaka T, Le TTT, Nguyen TG, Tran QB, Le THH, Pham XD: Oraladministration of Bifidobacterium spp. improves insulin resistance, induces adiponectin andprevents inflammatory adipokine expressions. Biomed Res. 35(5) 303～10 2014.
11. Hosaka T, Sasaga S, Yamasaka Y, Nii Y, Edazawa K, Tsutsumi R, Shuto E, Okahisa N,Iwata S, Tomotake H, Sakai T : Treatment with buckwheat bran extract prevents theelevation of serum triglyceride levels and fatty liver in KK-Ay mice. The journal of medical
investigation 61(3,4) 345～52 2014
12. Li Q, Hosaka T, Harada N, Nakaya Y, Funaki M: Activation of Akt through 5-HT2A
receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 inadipocytes. Mol Cell Endocrinol. 365(1):25～35 2013
13. Hosaka T, Nii Y, Tomotake H, Ito T, Tamanaha A, Yamasaka Y, Sasaga S, Edazawa K,Tsutsumi R, Shuto E, Okahisa N, Iwata S, Sakai T: Extracts of common buckwheat branprevent sucrose digestion. J Nutr Sci Vitaminol (Tokyo). 57(6) 441～445 2012
14. Li Q, Hosaka T, Shikama Y, Bando Y, Kosugi C, Kataoka N, Nakaya Y, Funaki M:
Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin
resistance through activation of EGF receptor-ERK1/2-mTOR pathway. Endocrinology
153(1) 56～68 2012.
15. Hirata Y, Hosaka T, Iwata T, Le CTK, Jambaldorj B, Teshigawara K, Harada N, Sakaue
H, Sakai T, Yoshimoto K Nakaya Y: Vimentin binds IRAP and is involved in GLUT4 vesicle
trafficking. Biochem Biophys Res Commun 405(1) 96～101 2011
16. Le CTK, Hosaka T, Harada N,Jambaldorj B Fukunaga K Nishiwaki Y, Teshigawara K,Sakai T, Nakaya Y, Funaki M, Myosin IIA participates in docking of Glut4 storage vesicles
with the plasma membrane in 3T3-L1 adipocytes Biochem Biophys Res Commun 391(1)995～999 2010
17. Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Harada N, Hosaka T, Nakaya Y,Ishidoh K, Obata T, Ebina Y, Gu H, Takeda S, Kishi K, Nikawa T.Deficiency of Cbl-b geneenhances infiltration and activation of macrophages in adipose tissue and causes peripheral
insulin resistance in mice. 2007 56: 2511 -2522 Diabetes.
18. Gross DN, Miyoshi H, Hosaka T, Zhang HH, Pino EC, Souza S, Obin M, Greenberg AS,
Pilch PF. Dynamics of lipid droplet-associated proteins during hormonally stimulated lipolysis

in engineered adipocytes: stabilization and lipid droplet binding of adipocyte differentiationrelated protein/adipophilinMolecular Endocrinology 20 : 459-466 200619. Hosaka T, Brooks CC, Presman E, Kim SK, Zhang Z, Breen M, Gross DN, Sztul E,andPilch PF. p115 interacts with the GLUT4 vesicle protein, IRAP, and plays critical role ininsulin-stimulated GLUT4 tranlocation. Molecular Biology of the Cell 16 : 2882-2890, 2005