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o-Tolidine solution,JUNSEI CHEMICAL CO., LTD.,96608jis_J_E2-1,08/02/2018
Date of issue: 08/02/2018

Safety Data Sheet

1. Identification of the substance/mixture and of the company/undertaking
Product identifier:Product name: o-Tolidine solution
Product code(SDS NO): 96608jis_J_E2-1
Details of the supplier of the safety data sheet
Manufacturer/Supplier: JUNSEI CHEMICAL CO., LTD.
Address: 1-6, Ohmano-Cho, Koshigaya, Saitama 343-0844, Japan
Division: Quality Assurance Department
Telephone number: +81-48-986-6161
FAX: +81-48-989-2787
e-mail address: shiyaku-t@junsei.co.jp

2. Hazards identification
GHS classification and label elements of the product
Classification of the substance or mixture
HEALTH HAZARDS
Acute toxicity Oral: Category 4
Acute toxicity Inhalation: Category 3
Skin corrosion/irritation: Category 1
Serious eye damage/eye irritation: Category 1
Respiratory sensitization: Category 1
Carcinogenicity: Category 1BSpecific target organ toxicity - single exposure: Category 2(respiratory system)
Specific target organ toxicity - repeated exposure: Category 2(tooth, respiratory system)
ENVIRONMENT HAZARDSHazardous to the aquatic environment - acute hazard: Category 2(Note) GHS classification without description: Not applicable/Out of classification/Not classifiable
Label elements

Signal word: Danger
HAZARD STATEMENT
Harmful if swallowed
Toxic if inhaled
Causes severe skin burns and eye damage
Causes serious eye damage
May cause allergy or asthma symptoms or breathing difficulties if inhaled
May cause cancer
May cause damage to organs after single exposure
May cause damage to organs through prolonged or repeated exposure
Toxic to aquatic life
PRECAUTIONARY STATEMENT
Prevention
Do not handle until all safety precautions have been read and understood.
Avoid release to the environment.
Do not breathe dust/mist.

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o-Tolidine solution,JUNSEI CHEMICAL CO., LTD.,96608jis_J_E2-1,08/02/2018
In case of inadequate ventilation wear respiratory protection. (as specified by themanufacturer/supplier or the competent authority.)
Use only outdoors or in a well-ventilated area.
Wash contaminated parts thoroughly after handling.
Wear protective gloves, protective clothing or face protection.
Wear eye protection/face protection.
Use personal protective equipment as required.
Do not eat, drink or smoke when using this product.
Response
Get medical advice/attention if you feel unwell.
Immediately call a POISON CENTER or doctor/physician.
If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
IF INHALED: Remove person to fresh air and keep comfortable for breathing.
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
Wash contaminated clothing before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, ifpresent and easy to do. Continue rinsing.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
Storage
Store in a well-ventilated place. Keep container tightly closed.
Store locked up.
Disposal
Dispose of contents/container in accordance with local/national regulation.

3. Composition/information on ingredients
Mixture/Substance selection:
MixtureIngredient name:o-Tolidine dihydrochloride
Content(%):0.13～0.15
Chemical formula:C14H18Cl2N2
Chemicals No, Japan:9-882
CAS No.:612-82-8
MW:285.21
ECNO:210-322-5
Ingredient name:Hydrogen chloride
Content(%):ca. 5.4
Chemical formula:ClH
Chemicals No, Japan:1-215
CAS No.:7647-01-0
MW:36.46
ECNO:231-595-7
Ingredient name:WaterContent(%):Residual quantity of the ingredient mentioned above.
Chemical formula:H2O
CAS No.:7732-18-5
MW:18.02
ECNO:231-791-2

4. First-aid measures3/8
o-Tolidine solution,JUNSEI CHEMICAL CO., LTD.,96608jis_J_E2-1,08/02/2018
Descriptions of first-aid measures
General measures
Get medical attention/advice if you feel unwell.
Immediately call a POISON CENTER or doctor/physician.
IF INHALED
Remove person to fresh air and keep comfortable for breathing.
If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
Call a POISON CENTER or doctor/physician if you feel unwell.
IF ON SKIN (or hair）
Take off immediately all contaminated clothing. Rinse skin with water/shower.
If skin irritation or rash occurs: Get medical advice/attention.
IF IN EYES
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWEDRinse mouth. Do NOT induce vomiting.
Call a POISON CENTER or doctor/physician if you feel unwell.

5. Fire-fighting measures
Extinguishing media
Suitable extinguishing media
Use appropriate extinguishing media suitable for surrounding facilities.
The product is non-flammable.
Specific hazards arising from the substance or mixture
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may cause pollution.
Advice for firefighters
Specific fire-fighting measures
Evacuate non-essential personnel to safe area.
Cool container with water spray.
Special protective equipment and precautions for fire-fighters
Wear fire/flame resistant/retardant clothing.
Wear protective gloves/protective clothing/eye protection/face protection.
Firefighters should wear self-contained breathing apparatus with full face peace operated
positive pressure mode.

6. Accidental release measures
Personnel precautions, protective equipment and emergency procedures
Keep unauthorized personnel away.
In case of contact with substance, immediately flush skin or eyes with running water for atleast 20 minutes.
Ventilate area after material pick up is complete.
Wear proper protective equipment.
PUBLIC SAFTY: Ventilate closed spaces before entering.
Environmental precautions
Avoid release to the rivers, lakes, ocean and groundwater.
Methods and materials for containment and cleaning up
Absorb spill with inert material (dry sand, earth, et al), then place in a chemical waste
container.
Use clean non-sparking tools to collect absorbed material.

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o-Tolidine solution,JUNSEI CHEMICAL CO., LTD.,96608jis_J_E2-1,08/02/2018
All equipment used when handling the product must be grounded.
Preventive measures for secondary accident
Collect spillage.
Stop leak if you can do it without risk.
Prevent entry into waterways, sewers, basements or confined areas.

7. Handling and storage
Precautions for safe handling
Preventive measures(Exposure Control for handling personnel)
Do not breathe dust/mist.
(Protective measures against fire and explosion)
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Exhaust/ventilator
Exhaust/ventilator should be available.
Safety treatments
Avoid contact with skin.
Avoid contact with eyes.
Avoid breathing dust or mist.
Safety Measures/IncompatibilityDo not handle until all safety precautions have been read and understood.
Use only outdoors or in a well-ventilated area.
Wear protective gloves, protective clothing or face protection.
Wear eye protection/face protection.
Use personal protective equipment as required.
When using do not eat, drink or smoke.
Conditions for safe storage, including any incompatibilities
Recommendation for storage
Store in a well-ventilated place. Keep container tightly closed.
Keep cool. Protect from sunlight.
Store locked up.

8. Exposure controls/personal protection
Control parameters
No control value data available in MHLW
Adopted value(Hydrogen chloride)
JSOH(2014) (ceiling limit) 2ppm; 3.0mg/m3
ACGIH(2000) STEL: C 2ppm (URT irr)
OSHA-PEL(Hydrogen chloride)
C 5ppm, 7mg/m3
Exposure controls
Appropriate engineering controls
Do not use in areas without adequate ventilation.
Eye wash station should be available.
Washing facilities should be available.
Individual protection measures
Respiratory protection
Wear respiratory protection.
Hand protection
Wear protective gloves.

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o-Tolidine solution,JUNSEI CHEMICAL CO., LTD.,96608jis_J_E2-1,08/02/2018
Consult with your glove and/or personnel equipment manufacturer for selection of
appropriate compatible materials.
Eye protection
Wear eye/face protection.
Safety and Health measures
Wash … thoroughly after handling.
Do not eat, drink or smoke when using this product.
Wash contaminated clothing before reuse.

9. Physical and Chemical Properties
Information on basic physical and chemical properties
Physical properties
Appearance: Liquid
Color: Colorless
Odor data N.A.
pH: Strong acidic
Phase change temperature
Initial Boiling Point/Boiling point data N.A.
Melting point/Freezing point data N.A.
Decomposition temperature data N.A.
Flash point data N.A.
Auto-ignition temperature data N.A.
Explosive properties data N.A.
Vapor pressure data N.A.
Vapor density data N.A.
Specific gravity/Density data N.A.
Solubility
Solubility in water: Miscible
n-Octanol /water partition coefficient data N.A.

10. Stability and Reactivity
Reactivity
Runaway polymerization will not occur.
Chemical stability
Stable under normal storage/handling conditions.
Conditions to avoid
Contact with incompatible materials.
Heat.
Incompatible materials
Bases
Hazardous decomposition productsCarbon oxides, Nitrogen oxides, Chlorides

11. Toxicological Information
Information on toxicological effects
Acute toxicity
Acute toxicity (Oral)[GHS Cat. Japan, base data](Hydrogen chloride) rat LD50 =238 mg/kg (SIDS, 2009)
Acute toxicity (Inhalation)[GHS Cat. Japan, base data]

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o-Tolidine solution,JUNSEI CHEMICAL CO., LTD.,96608jis_J_E2-1,08/02/2018(Hydrogen chloride) mist : rat LC50=0.42 mg/L/4hr （SIDS, 2009)
Labor standard law, Japan; Toxic
Hydrogen chloride
Irritant properties
Skin corrosion/irritation[GHS Cat. Japan, base data](Hydrogen chloride) rabbit/mouse/rat/human : corrosive (SIDS, 2009)
Serious eye damage /irritation[GHS Cat. Japan, base data](Hydrogen chloride) rabbit : corrosive (SIDS, 2002)
Sensitization
Respiratory sensitization[GHS Cat. Japan, base data](Hydrogen chloride) cat.1; Occupational/Environmental Allergy Society, Japan
No Mutagenic effects data available
Carcinogenicity(Hydrogen chloride)
IARC-Gr.3 : Not Classifiable as a Human Carcinogen
ACGIH-A4(2000) : Not Classifiable as a Human Carcinogen(o-Tolidine dihydrochloride)
EU-Category 1B; Substances presumed to have carcinogenic potential for humans
No reproductive toxicity data available
Delayed and immediate effects and also chronic effects from short- and long-term exposure
STOTSTOT-single exposure[cat.1][Japan published data](Hydrogen chloride) respiratory apparatus/system ( ACGIH, 2003 )[cat.3(resp. irrit.)][Japan published data](o-Tolidine dihydrochloride) Respiratory tract irritation ( EPA_JP risk assessment vol4,
2005 )
STOT-repeated exposure[cat.1][Japan published data](Hydrogen chloride) teeth; respiratory apparatus/system ( SIDS, 2002 )No Aspiration hazard data available
Additional data
There are no data available on the preparation itself.

12. Ecological Information
Ecotoxicity
Aquatic toxicity
Toxic to aquatic life
Aquatic acute toxicity component(s) data
[GHS Cat. Japan, base data](Hydrogen chloride) Crustacea（Daphnia magna） EC50=0.492mg/L/48hr （SIDS, 2005）
Water solubility(Hydrogen chloride) 67 g/100 ml (30℃) (ICSC, 2000)
No Persistence and degradability data available
Bioaccumulative potential(Hydrogen chloride) log Pow=0.25 (ICSC, 2000)

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o-Tolidine solution,JUNSEI CHEMICAL CO., LTD.,96608jis_J_E2-1,08/02/2018
Additional information
There are no data available on the preparation itself.

13. Disposal considerations
Waste treatment methods
Avoid release to the environment (- if this is not the intended use).
Dispose of contents/container in accordance with local/national regulation.

14. Transport Information
UN No, UN CLASS
UN number: 1789
UN proper shipping name: HYDROCHLORIC ACID
Transport hazard class(es): 8
Packing group: II
ERG GUIDE NO.: 157

15. Regulatory Information
Safety, health and environmental regulations/legislation specific for the substance or mixture
Transport in bulk according to Annex II of MARPOL73/78 and IBC Code
Noxious Liquid ; Cat. Z
Hydrogen chloride
Non Noxious Liquid ; Cat. OS
Water
US major regulations
TSCA
o-Tolidine dihydrochloride; Hydrogen chloride; Water
Other regulatory information
We are not able to check up the regulatory information in regard to the substances in yourcountry or region, therefore, we request this matter would be filled by your responsibility.
Regulatory information with regard to this substance in your country or in your region
should be examined by your own responsibility.
Ensure this material in compliance with federal requirements and ensure conformity to local
regulations.

16. Other information
GHS classification and labelling
Acute Tox. 4: H302 Harmful if swallowed
Acute Tox. 3: H331 Toxic if inhaled
Skin Corr. 1: H314 Causes severe skin burns and eye damage
Eye Dam. 1: H318 Causes serious eye damage
Resp. Sens. 1: H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Carc. 1B: H350 May cause cancer
STOT SE 2: H371 May cause damage to organs after single exposure
STOT RE 2: H373 May cause damage to organs through prolonged or repeated exposure
Aquatic Acute 2: H401 Toxic to aquatic life
Reference Book
Globally Harmonized System of classification and labelling of chemicals, (5th ed., 2013), UN
Recommendations on the TRANSPORT OF DANGEROUS GOODS 19th edit., 2015 UN
Classification, labelling and packaging of substances and mixtures (table3-1 ECNO6182012)2016 EMERGENCY RESPONSE GUIDEBOOK (US DOT)

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o-Tolidine solution,JUNSEI CHEMICAL CO., LTD.,96608jis_J_E2-1,08/02/20182017 TLVs and BEIs. (ACGIH)
http://monographs.iarc.fr/ENG/Classification/index.phpSupplier's data/information
NITE Chemical Risk Information Platform（NITE-CHRIP）http://www.safe.nite.go.jp/japan/db.html
GHS Classification Guidance for Enterprises 2013 Revised Edition （August, 2013,METI)
General Disclaimer
This information contained in this data sheet represents the best information currently
available to us. However, no warranty is made with respect to its completeness and weassume no liability resulting from its use. It are advised to make their own tests todeterminate the safety and suitability of each such product or combination for their own
purposes.
The data given here is based on current knowledge and experience. The purpose of thisSafety Data Sheet is to describe the products in terms of their safety requirements. Thedata does not signify any warranty with regard to the products' properties.
The GHS classification data given here is based on current Japan official data (NITE published in2016).
But the data are partially changed based on our judgement.